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Sample records for system pas port

  1. Patency of Saphenous Vein Grafts Using the PAS-Port System During Coronary Artery Bypass Surgery.

    Science.gov (United States)

    Kubota, Hiroshi; Endo, Hidehito; Ishii, Hikaru; Tsuchiya, Hiroshi; Takahashi, Yu; Inaba, Yusuke; Noma, Mio; Yoshimoto, Akihiro; Higuchi, Satoshi; Kohshoh, Hideyasu; Taniai, Seiichi; Ishiguro, Haruhisa; Yoshino, Hideaki; Sudo, Kenichi

    2017-08-01

    Several proximal anastomosis devices have been developed to shorten the time required for a proximal anastomosis and to avoid aortic cross-/side-clamping during coronary artery bypass grafting. This study retrospectively examined the patency of saphenous vein grafts (SVGs) using the PAS-Port System (Cardia Inc, Redwood City, CA). From 2004 to 2014, 451 patients underwent coronary artery bypass graft operations requiring at least 1 proximal anastomosis using a PAS-Port device. A total of 802 PAS-Port devices were used, and 95.0% (762 of 802) were implanted successfully. Among the successfully implanted anastomoses, 76.8% (585 of 762) were evaluated using coronary angiography or multidimensional computed tomography, or both. The evaluations were performed between postoperative days 4 and 3,182 (mean, 319 ± 624 days). The early (1 to 365 days) and the midterm to long-term (more than 366 days) occlusion rates were examined. A complete postoperative clinical course was recorded for 70.7% of the patients. Overall, 93.8% (549 of 585) of the device-dependent SVGs were patent. The patency rates of device-dependent SVGs that were 1, 2, 3, 4, 5, 6, 7, and 8 years old were 90.1% ± 1.8%, 87.1% ± 2.3%, 86.1% ± 2.5%, 82.9% ± 3.3%, 80.6% ± 3.9%, 77.2% ± 5.0%, 77.2% ± 5.0%, and 70.2% ± 8.1%, respectively. The longest follow-up period was 3,182 days (8.7 years). The occlusion rate for device-dependent SVGs tended to decrease as the number of patients accumulated. The PAS-Port system provided acceptable SVG patency and clinical outcome for the early and midterm to long-term. There may be a learning curve for the use of PAS-Port device that affects the device-dependent SVG patency. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  2. Morphological Evaluation of Proximal Anastomosis by PAS-Port(®) System in Patients with Long-Term Patent Grafts.

    Science.gov (United States)

    Kawasaki, Muneyasu; Fujii, Takeshiro; Hara, Masanori; Sasaki, Yuki; Katayanagi, Tomoyuki; Okuma, Shinnosuke; Watanabe, Yoshinori

    2015-01-01

    We examined grafts employing for morphological analysis of early and long-term results on proximal anastomosis with the PAS-Port(®). One hundred and four patients treated by OPCAB with PAS-Port(®) were performed postoperative MDCT. Morphological evaluation of the proximal anastomotic region was classified into three groups (A; graft was anastomosed almost perpendicularly to the aortic wall, B; graft was same type A, but subsequently curved to form an acute angle with the aortic wall, C; graft take off acute angle with the aortic wall) evaluated on planar and sagittal sections. One hundred twenty-six PAS-Port(®) were used. Patency rate was 99.0% at discharge, 94.7% at 1 year, and no blockages were detected thereafter in patients examined. The morphology rate was A 50.6%, B 15.3% and C 34.1% on planar sections, and A 58.8%, B 10.6% and C 30.6% on sagittal sections. The morphological evaluation of grafts revealed the degree of freedom in graft design to be relatively high and long-term patency posed no particular problem even if the layout of the proximal anastomotic region involved a relatively acute angle. The PAS-Port(®) was considered to be a highly reliable device which performed appropriate proximal anastomosis and improved the patency of vein grafting to the aortic wall.

  3. Manual for THOR-AirPAS - air pollution assessment system

    DEFF Research Database (Denmark)

    Jensen, Steen Solvang; Ketzel, Matthias; Brandt, Jørgen

    The report provides an outline of the THOR-AirPAS - air pollution assessment system and a brief manual for getting started with the air quality models and input data included in THOR-AirPAS.......The report provides an outline of the THOR-AirPAS - air pollution assessment system and a brief manual for getting started with the air quality models and input data included in THOR-AirPAS....

  4. Systems theory of interconnected port contact systems

    NARCIS (Netherlands)

    Eberard, D.; Maschke, B.M.; Schaft, A.J. van der

    2005-01-01

    Port-based network modeling of a large class of complex physical systems leads to dynamical systems known as port-Hamiltonian systems. The key ingredient of any port-Hamiltonian system is a power-conserving interconnection structure (mathematically formalized by the geometric notion of a Dirac

  5. Memristive port-Hamiltonian Systems

    NARCIS (Netherlands)

    Jeltsema, Dimitri; Schaft, Arjan J. van der

    2010-01-01

    The port-Hamiltonian modelling framework is extended to a class of systems containing memristive elements and phenomena. First, the concept of memristance is generalised to the same generic level as the port-Hamiltonian framework. Second, the underlying Dirac structure is augmented with a memristive

  6. Discrete port Hamiltonian systems

    NARCIS (Netherlands)

    Talasila, V.; Clemente-Gallardo, J.; Clemente Gallardo, J.J.; van der Schaft, Arjan; Horacek, P; Simandl, M; Zitek, P

    2005-01-01

    Either from a control theoretic viewpoint or from an analysis viewpoint it is necessary to convert smooth systems to discrete systems, which can then be implemented on computers for numerical simulations. Discrete models can be obtained either by discretizing a smooth model, or by directly modeling

  7. Notch filters for port-Hamiltonian systems

    NARCIS (Netherlands)

    Dirksz, D.A.; Scherpen, J.M.A.; van der Schaft, A.J.; Steinbuch, M.

    2012-01-01

    In this paper a standard notch filter is modeled in the port-Hamiltonian framework. By having such a port-Hamiltonian description it is proven that the notch filter is a passive system. The notch filter can then be interconnected with another (nonlinear) port-Hamiltonian system, while preserving the

  8. Port-Hamiltonian systems: an introductory survey

    NARCIS (Netherlands)

    van der Schaft, Arjan; Sanz-Sole, M.; Soria, J.; Varona, J.L.; Verdera, J.

    2006-01-01

    The theory of port-Hamiltonian systems provides a framework for the geometric description of network models of physical systems. It turns out that port-based network models of physical systems immediately lend themselves to a Hamiltonian description. While the usual geometric approach to Hamiltonian

  9. Form Quality in Rorschach Comprehensive System and R-PAS: Sample of Psychiatric Cases

    Directory of Open Access Journals (Sweden)

    Latife Yazigi

    2016-04-01

    Full Text Available Abstract The creation of the Rorschach Performance Assessment System (R-PAS requires research that allows its use in the Brazilian population. The Formal Quality (FQ category is essential both for clinic and research. The aim of this study was to compare form quality variables in Rorschach protocols from psychiatric patients and ratings coded in the Comprehensive System (CS and R-PAS. The sample comprised 206 Rorschach protocols from adult patients in psychiatric treatment, who were also assessed by SCID-I and SCID-II. Most protocols were administered in the CS and recoded according to the R-PAS. The kappa coefficient was calculated, and we compared the means of these variables in both systems. The kappa results varied from almost perfect to substantial consistency for all variables, however, the descriptive statistics confirmed that the R-PAS elicits more FQ Ordinary coding while the CS elicits more FQ minus coding.

  10. Anaortic off-pump versus clampless off-pump using the PAS-Port device versus conventional coronary artery bypass grafting: mid-term results from a matched propensity score analysis of 5422 unselected patients.

    Science.gov (United States)

    Furukawa, Nobuyuki; Kuss, Oliver; Preindl, Konstantin; Renner, André; Aboud, Anas; Hakim-Meibodi, Kavous; Benzinger, Michael; Pühler, Thomas; Ensminger, Stephan; Fujita, Buntaro; Becker, Tobias; Gummert, Jan F; Börgermann, Jochen

    2017-10-01

    Meta-analyses from observational and randomized studies have demonstrated benefits of off-pump surgery for hard and surrogate endpoints. In some of them, increased re-revascularization was noted in the off-pump groups, which could impact their long-term survival. Therefore, we analyzed the course of all patients undergoing isolated coronary surgery regarding the major cardiac and cerebrovascular event (MACCE) criteria. A prospective register was taken from a high-volume off-pump center recording all anaortic off-pump (ANA), clampless off-pump (PAS-Port) and conventional (CONV) coronary artery bypass operations between July 2009 and June 2015. Propensity Score Matching was performed based on 28 preoperative risk variables. We identified 935 triplets (N = 2805). Compared with CONV, in-hospital mortality of both the ANA group (OR for ANA [95% CI] 0.25 [0.06; 0.83], P = 0.021), and the PAS-Port group was lower (OR for PAS-Port [95% CI] 0.50 [0.17; 1.32], P = 0.17). In the mid-term follow-up there were no significant differences between the groups regarding mortality (HR for ANA [95%-CI] 0.83 [0.55-1.26], P = 0.38; HR for PAS-Port [95%-CI] 1.06 [0.70-1.59], P = 0.79), incidence of stroke (HR for ANA 0.81 [0.43-1.53], P = 0.52; HR for PAS-Port 0.78 [0.41-1.50], P = 0.46), myocardial infarction (HR for ANA 0.53 [0.22-1.31], P = 0.17; HR for PAS-Port 0.78 [0.37-1.66], P = 0.52) or re-revascularization rate (HR for ANA 0.99 [0.67-1.44], P = 0.94; HR for PAS-Port 0.95 [0.65-1.38], P = 0.77). Both off-pump clampless techniques were associated with lower in-hospital mortality compared with conventional CABG. The mid-term course showed no difference with regard to the MACCE criteria between anaortic off-pump, clampless off-pump using PAS-Port and conventional CABG.

  11. Notch filters for port-Hamiltonian systems

    NARCIS (Netherlands)

    Dirksz, Daniel; Scherpen, Jacquelien M.A.; van der Schaft, Abraham; Steinbuch, M.

    2012-01-01

    Network modeling of lumped-parameter physical systems naturally leads to a geometrically defined class of systems, i.e., port-Hamiltonian (PH) systems [4, 6]. The PH modeling framework describes a large class of (nonlinear) systems including passive mechanical systems, electrical systems,

  12. SELECTED REQUIREMENTS OF INTEGRATED MANAGEMENT SYSTEMS BASED ON PAS 99 SPECIFICATION

    Directory of Open Access Journals (Sweden)

    Paweł Nowicki

    2013-03-01

    Full Text Available The aim this research was to analyze the ways of integration of management systems in food sector. The study involved the documentation, audits, corrective and preventive actions and management's review phases described in the specification PAS 99, which is one of common elements of integrated management systems. Four organizations were selected for the study. The organizations had introduced and certified at least two standardized management systems. It was assumed that the investigated organizations should have implemented the HACCP system. Studies were conducted as a case study. The employees responsible for the functioning of management systems were interviewed in all four organizations. The study was conducted in the form of in-depth interviews based on pre-prepared script. The scenario was developed based on the PAS 99 guideline. The process of integration of management systems implemented in the studied companies reveals the full compliance of an integrated management system with PASS 99 in the policy area.

  13. Devins sur le pas de la porte : notes pour une anthropologie visuelle du seuil en Galice

    Directory of Open Access Journals (Sweden)

    Anxo Fernández Ocampo

    2010-04-01

    Full Text Available Cet article est le résultat d'une expérience au carrefour de la traductologie et de l'anthropologie visuelle. Il met en lumière la capacité des seuils domestiques à gérer l'étranger au moyen de traces ou d'objets auxquels on confère une valeur exotisante, soit parce que ces traces ou ces objets sont des représentations identitaires du passé, soit parce qu'ils incarnent l'autre et l'ailleurs. Le terrain de recherche est en milieu rural, et s'étend sur plusieurs hameaux d'une même commune du nord-est de la Galice. Dans la méthodologie mise en œuvre, l'observateur se substitue au passant et au visiteur pour photographier les seuils et les signes, principalement sur le vantail des portes, authentiques supports d'écriture. Il tente également d'engager un dialogue avec l'habitant, voire de franchir le seuil : cette interaction permet de valider l'expérience et de satisfaire l'équilibre entre les contraintes techniques et le cadre épistémologique de la recherche. C'est ainsi que sont analysés plusieurs phénomènes, que ce soit l'acceptabilité culturelle et scripturale d'un nom propre étranger, l'installation d'objets qui nouent un dialogue avec le passant, ou l'agencement d'icônes sacrifiées sur des autels domestiques. Le seuil étant par excellence un espace traduisant, l'article s'attache finalement à révéler le rôle de tout habitant en tant que négociateur de l'altérité, intermédiaire à part entière des opérations transculturelles, et pose la nécessité d'élargir l'horizon et les méthodes de recherche descriptive de la traductologie vers la lecture des espaces du seuil et, en définitive, vers l'étude des pratiques populaires de significationThis article is the result of an experience at the crossroads of traductology and visual anthropology. It highlights the capacity of the domestic thresholds to cope with the alien by the means of traces or objects that are invested with an “exoticising” value, either

  14. Discrete port-Hamiltonian systems

    NARCIS (Netherlands)

    Talasila, V.; Clemente-Gallardo, J.; Schaft, A.J. van der

    2006-01-01

    Either from a control theoretic viewpoint or from an analysis viewpoint it is necessary to convert smooth systems to discrete systems, which can then be implemented on computers for numerical simulations. Discrete models can be obtained either by discretizing a smooth model, or by directly modeling

  15. The HomePort System

    DEFF Research Database (Denmark)

    Brønsted, Jeppe; Madsen, Per Printz; Skou, Arne

    2010-01-01

    Residential gateways for home automation are prerequisites to obtain optimal exploitation of energy resources, and they also have the potential to provide a unified operation of various home devices and appliances. Although a number of protocol standards have been proposed, the number of commerci......Residential gateways for home automation are prerequisites to obtain optimal exploitation of energy resources, and they also have the potential to provide a unified operation of various home devices and appliances. Although a number of protocol standards have been proposed, the number...... middleware system for residential gateways including a simple composition language. Also, we present the initial experiences obtained from a prototype implementation of the system...

  16. Managing Temporal Knowledge in Port Management Systems

    Directory of Open Access Journals (Sweden)

    Anita Gudelj

    2006-05-01

    Full Text Available Large ports need to deal with a number of disparate activities:the movement of ships, containers and other cargo, theloading and unloading of ships and containers, customs activities.As well as human resources, anchorages, channels, lighters,tugs, berths, warehouse and other storage spaces have to beallocated and released. The efficient management of a port involvesmanaging these activities and resources, managing theflows of money involved between the agents providing and usingthese resources, and providing management information.Many information systems will be involved.Many applications have to deal with a large amount of datawhich not only represent the perceived state of the real world atpresent, but also past and/or future states. These applicationsare not served adequately by today's computer managementand database systems. In particular, deletions and updates insuch systems have destructive semantics. This means that previousdatabase contents (representing previous perceived statesof the real world cannot be accessed anymore.A review of how define temporal data models, based ongeneralizing a non-temporal data model in to a temporal one toimprove port management is presented. This paper describes apractical experiment which supports managing temporal dataalong with the corresponding prototype implementations.

  17. System аnalysis concession maritime trade ports

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    Y.V. Shmatock

    2015-03-01

    Full Text Available The article proves the significance of maritime commercial ports as strategic for the country. The urgency of port concessions to improve transport infrastructure. The definition of ports in terms of system analysis and determination of management port. Outlined the sequence of system analysis concessions maritime trade ports in the table. Selection of qualified managers is based on the concession tender under prescribed conditions. These criteria should be considered when determining the concessionaire. These stages of the concession tender. Meeting the needs of the economy, international trade, public inquiries into transportation of goods is not possible without the efficient operation of maritime trade ports. Only complex technological modernization of maritime trade ports will enable them to take leadership positions. Tree depicted objectives effectively manage commercial sea port. Therefore, initiation of concessions needs to implement measures to achieve the talented and skillful result.

  18. An Interrater Reliability Study of Rorschach Performance Assessment System (R-PAS) Raw and Complexity-Adjusted Scores.

    Science.gov (United States)

    Pignolo, Claudia; Giromini, Luciano; Ando', Agata; Ghirardello, Davide; Di Girolamo, Marzia; Ales, Francesca; Zennaro, Alessandro

    2017-01-01

    Recently, the Rorschach Performance Assessment System (R-PAS; Meyer, Viglione, Mihura, Erard, & Erdberg, 2011 ) was introduced to overcome some possible limitations of the Comprehensive System (CS; Exner, 2003 ) while continuing its efforts to link Rorschach inferences to their evidence base. An important, technical modification to the scoring system is that R-PAS interpretations are based on both standard scores and complexity-adjusted scores. Two previous U.S. studies reported good to excellent interrater reliability (IRR) for the great majority of R-PAS variables; however, IRR of complexity-adjusted scores has never been investigated. Furthermore, no studies have yet investigated R-PAS IRR in Europe. To extend this literature, we examined R-PAS IRR of Page 1 and Page 2 raw and complexity-adjusted scores with 112 Italian Rorschach protocols. We collected a large sample of both clinical and nonclinical Rorschach protocols, each of which was coded separately by 2 independent raters. Results demonstrated a mean intraclass correlation of .78 (SD = .14) for raw scores and.74 (SD = .14) for complexity-adjusted scores. Overall, for both raw and complexity-adjusted values, most of the variables were characterized by good to excellent IRR.

  19. The Re-Conceptualization of the Port Supply Chain as a Smart Port Service System: The Case of the Port of Salerno

    Directory of Open Access Journals (Sweden)

    Antonio Botti

    2017-04-01

    Full Text Available This paper proposes a re-conceptualization of the port supply chain as a smart service system, in accordance with the theory of service science. Starting from a short literature review about the port supply chain approach and service science, a new comprehensive framework is provided to better understand seaport dynamics and the creation of competitive port supply chains. The methodology used is the case study approach. The Authors examined the Port of Salerno (Italy and re-conceptualized it as a smart port service system. The originality of the work lies in the application of service science as a lens to re-conceptualize the port supply chain, that allows the implementation of a logistic framework. Both theoretical and practical implications are provided to enrich the literature about port supply chains and to support port operators.

  20. Distributed port-Hamiltonian formulation of infinite dimensional systems

    NARCIS (Netherlands)

    Macchelli, Alessandro; Macchelli, A.; van der Schaft, Arjan; Melchiorri, Claudio

    2004-01-01

    In this paper, some new results concerning the modeling and control of distributed parameter systems in port Hamiltonian form are presented. The classical finite dimensional port Hamiltonian formulation of a dynamical system is generalized in order to cope with the distributed parameter and

  1. Distributed Port-Hamiltonian Formulation of Innite Dimensional Systems

    NARCIS (Netherlands)

    Macchelli, Alessandro; Schaft, Arjan J. van der; Melchiorri, Claudio

    2004-01-01

    In this paper, some new results concerning the modeling and control of distributed parameter systems in port Hamiltonian form are presented. The classical finite dimensional port Hamiltonian formulation of a dynamical system is generalized in order to cope with the distributed parameter and

  2. Discrete-Time Models for Implicit Port-Hamiltonian Systems

    OpenAIRE

    Castaños, Fernando; Michalska, Hannah; Gromov, Dmitry; Hayward, Vincent

    2015-01-01

    Implicit representations of finite-dimensional port-Hamiltonian systems are studied from the perspective of their use in numerical simulation and control design. Implicit representations arise when a system is modeled in Cartesian coordinates and when the system constraints are applied in the form of additional algebraic equations (the system model is in a DAE form). Such representations lend themselves better to sample-data approximations. An implicit representation of a port-Hamiltonian sys...

  3. Rorschach Performance Assessment System (R-PAS) and vulnerability to stress: A preliminary study on electrodermal activity during stress.

    Science.gov (United States)

    Giromini, Luciano; Ando', Agata; Morese, Rosalba; Salatino, Adriana; Di Girolamo, Marzia; Viglione, Donald J; Zennaro, Alessandro

    2016-12-30

    This study investigated the predictive validity of the ten Rorschach Performance Assessment System (R-PAS) variables from the Stress and Distress domain, by testing whether they predicted increased sympathetic reactivity to a mild, laboratory-induced stress, occurred one week after Rorschach administration. A relatively small student sample (N=52) contributed to this research: During a first meeting (T1) participants were administered the Rorschach task according to R-PAS guidelines; about one week later (T2) their electrodermal activity (EDA) was recorded during exposure to a mild laboratory stress-inducing task. Based on literature indicating that exposure to stress tends to increase physiological vulnerability/reactivity to stressful situations, we anticipated that Stress and Distress R-PAS variables measured at T1 would positively correlate with increased sympathetic reactivity to stress at T2, as indicated by greater EDA changes from baseline to stress and recovery. Results partially confirmed our hypotheses: (a) the mean of and (b) the majority of the Stress and Distress R-PAS variables were significantly correlated, in the expected direction, with medium and medium to large effect sizes. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  4. Interconnection of port-Hamiltonian systems and composition of Dirac structures

    NARCIS (Netherlands)

    Cervera, J.; van der Schaft, Arjan; Baños, A.

    2007-01-01

    Port-based network modeling of physical systems leads to a model class of nonlinear systems known as port-Hamiltonian systems. Port-Hamiltonian systems are defined with respect to a geometric structure on the state space, called a Dirac structure. Interconnection of port-Hamiltonian systems results

  5. Interconnection of port-Hamiltonian systems and composition of Dirac structures

    NARCIS (Netherlands)

    Cervera, J.; Schaft, A.J. van der; Baños, A.

    Port-based network modeling of physical systems leads to a model class of nonlinear systems known as port-Hamiltonian systems. Port-Hamiltonian systems are defined with respect to a geometric structure on the state space, called a Dirac structure. Interconnection of port-Hamiltonian systems results

  6. GPON system with user controlled port-ID assignment method

    Science.gov (United States)

    Zhang, Na; Yoshiuchi, Hideya

    2008-11-01

    Passive Optical Network (PON) system with characters of low-cost and high-efficiency has become a promising solution for access network in relieving the bandwidth bottleneck problem. PON system can provide high-speed optical subscriber networks with broad bandwidth and long distance transmission. In current telecommunication carriers' PON system, different service has its given priority which is configured by carriers based on common requirements. However, different users have their own requirement and inflexibility of the given default service priority causes users' inconvenience and frustration. In this paper, we propose a novel method of user controlled Port-IDentifier (Port-ID) assignment in a Gigabit-capable PON (GPON) system. This method provides users a more individualized priority determination mechanism for end users through assigning a multi-level Port-ID to different service. Then users can manage their own bandwidth based on their requirements for different service and carriers can provide a flexible service management mechanism.

  7. IMPACTS OF ACTIVITIES IN PORT SYSTEM ESTUARINE SANTOS

    Directory of Open Access Journals (Sweden)

    Orlando Roque da Silva

    2015-03-01

    Full Text Available It is increasing the preoccupation with the estuary system due to the importance that it presents and its unique environmental characteristics that result in high biological productivity. In this work we analyze the impacts caused in Santos Estuary System by the port activities. In the lasts years, urban settings and the development of industrial, port, fishing activities, mineral exploration, tourist activities, and others, without adequate planning, comes placing in scratch the basic attributes Brazilian estuaries and ecosystems associates, resulting in local population life quality decrease.

  8. Structure Preserving Adaptive Control of Port-Hamiltonian Systems

    NARCIS (Netherlands)

    Dirksz, Daniel A.; Scherpen, Jacquelien M. A.

    2012-01-01

    In this technical note, an adaptive control scheme is presented for general port-Hamiltonian systems. Adaptive control is used to compensate for control errors that are caused by unknown or uncertain parameter values of a system. The adaptive control is also combined with canonical transformation

  9. Physical Oceanographic Real-Time System (PORTS) (Invited)

    Science.gov (United States)

    Wright, D.

    2013-12-01

    The 1999 Assessment of U.S. Marine Transportation System report to Congress noted that the greatest safety concern voiced by the maritime community was the availability of timely, accurate, and reliable navigation information, including real time environment data. Real time oceanographic and meteorological data, along with other navigation tools, gives the mariner a good situational understanding of their often challenging operational environment, to make the best safety of life and property decisions. The National Oceanic and Atmospheric Administration's (NOAA) Physical Oceanographic Real Time System (PORTS) was developed in response to accidents like the Sunshine Skyway Bridge collision in Tampa, FL in 1980, where the lack of accurate, reliable and timely environmental conditions directly contributed to an accident that resulted in a high loss of life and property. Since that time, PORTS has expanded to over 20 locations around the country, and its capabilities have been continually expanded and improved as well. PORTS primary mission is to prevent maritime accidents. Preventing an accident from occurring is the most cost effective approach and the best way to avoid damage to the environment. When accidents do occur, PORTS data is used to improve the effectiveness of response efforts by providing input for trajectory models and real time conditions for response efforts. However, benefits derived from PORTS go well beyond navigation safety. Another large benefit to the local maritime community is potential efficiencies in optimizing use of the existing water column. PORTS provides information that can be used to make economic decisions to add or offload cargo to a vessel and/or to maintain or adjust transit schedules based upon availability of water depth, strength/timing of tidal currents, and other conditions. PORTS data also helps improve and validate local National Weather Service marine weather forecasts. There are many benefits beyond the local maritime

  10. Waveform Developer's Guide for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio

    Science.gov (United States)

    Shalkhauser, Mary Jo W.; Roche, Rigoberto

    2017-01-01

    The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS-compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx(Trademark) ML605 Virtex(Trademark)-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek(Trademark) eBox 620-110-FL) running the Ubuntu 12.4 operating system. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications. The purpose of this document is to describe how to develop a new waveform using the RIACS platform and the Very High Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) FPGA wrapper code and the STRS implementation on the Axiomtek processor.

  11. Organizational and Managerial Structures, Financing and Other Elements of the Port System of Slovenia

    Directory of Open Access Journals (Sweden)

    Milojka Počuča

    2007-01-01

    Full Text Available The article gives a presentation of the port system of theRepublicof Slovenia and of the organizational, ownership andmanagerial structure of Slovenia's only cargo port in Koper.The analysis of the organizational, ownership and managerialstructure was carried out according to the methodology appliedin the European project entitled "Commission Staff WorkingProject on Public Financing and Charging Practices in theCommunity Sea Port Sector". The article performs a compara·tive analysis of the port of Koper with other ports of the EU inthe domain of organization, ownership and management, publicfinancing, accountancy monitoring of public money investedin the port infrastructure, principles of cost recovery ofinvested capital and possibilities of access of port operators tothe port infrastructure of the Slovenian cargo port. The articlepoints to the possibilities of ownership and managementchanges in the port of Koper.

  12. Structure-preserving tangential interpolation for model reduction of port-Hamiltonian systems

    NARCIS (Netherlands)

    Gugercin, Serkan; Polyuga, Rostyslav V.; Beattie, Christopher; Schaft, Arjan van der

    Port-Hamiltonian systems result from port-based network modeling of physical systems and are an important example of passive state-space systems. In this paper, we develop a framework for model reduction of large-scale multi-input/multi-output port-Hamiltonian systems via tangential rational

  13. Structure-preserving tangential interpolation for model reduction of port-Hamiltonian Systems

    OpenAIRE

    Gugercin, Serkan; Polyuga, Rostyslav V.; Beattie, Christopher; van der Schaft, Arjan

    2011-01-01

    Port-Hamiltonian systems result from port-based network modeling of physical systems and are an important example of passive state-space systems. In this paper, we develop the framework for model reduction of large-scale multi-input/multi-output port-Hamiltonian systems via tangential rational interpolation. The resulting reduced-order model not only is a rational tangential interpolant but also retains the port-Hamiltonian structure; hence is passive. This reduction methodology is described ...

  14. Adaptive control of port-Hamiltonian systems

    NARCIS (Netherlands)

    Dirksz, Daniel; Scherpen, Jacquelien M.A.

    2010-01-01

    Adaptive control is an alternative approach for controlling systems which are sensitive to parameter uncertainty. With adaptive control it is possible to estimate parameter errors and to compensate for those errors. This can result in a better performance of the controlled system. Some techniques

  15. Notch Filters for Port-Hamiltonian Systems

    NARCIS (Netherlands)

    Dirksz, Danny; Scherpen, Jacquelien M.A.; van der Schaft, Abraham J.; Steinbuch, Maarten

    Many powerful tools exist for control design in the frequency domain, but are theoretically only justified for linear systems. On the other hand, nonlinear control deals with control design methodologies that are theoretically justified for a larger and more realistic class of systems, but primarily

  16. Refrigeration system having dual suction port compressor

    Science.gov (United States)

    Wu, Guolian

    2016-01-05

    A cooling system for appliances, air conditioners, and other spaces includes a compressor, and a condenser that receives refrigerant from the compressor. The system also includes an evaporator that receives refrigerant from the condenser. Refrigerant received from the condenser flows through an upstream portion of the evaporator. A first portion of the refrigerant flows to the compressor without passing through a downstream portion of the evaporator, and a second portion of the refrigerant from the upstream portion of the condenser flows through the downstream portion of the evaporator after passing through the upstream portion of the evaporator. The second portion of the refrigerant flows to the compressor after passing through the downstream portion of the evaporator. The refrigeration system may be configured to cool an appliance such as a refrigerator and/or freezer, or it may be utilized in air conditioners for buildings, motor vehicles, or other such spaces.

  17. Cooling system having dual suction port compressor

    Science.gov (United States)

    Wu, Guolian

    2017-08-29

    A cooling system for appliances, air conditioners, and other spaces includes a compressor, and a condenser that receives refrigerant from the compressor. The system also includes an evaporator that receives refrigerant from the condenser. Refrigerant received from the condenser flows through an upstream portion of the evaporator. A first portion of the refrigerant flows to the compressor without passing through a downstream portion of the evaporator, and a second portion of the refrigerant from the upstream portion of the condenser flows through the downstream portion of the evaporator after passing through the upstream portion of the evaporator. The second portion of the refrigerant flows to the compressor after passing through the downstream portion of the evaporator. The refrigeration system may be configured to cool an appliance such as a refrigerator and/or freezer, or it may be utilized in air conditioners for buildings, motor vehicles, or other such spaces.

  18. Port Protocols for Deadlock-Freedom of Component Systems

    Directory of Open Access Journals (Sweden)

    Christian Lambertz

    2010-10-01

    Full Text Available In component-based development, approaches for property verification exist that avoid building the global system behavior of the component model. Typically, these approaches rely on the analysis of the local behavior of fixed sized subsystems of components. In our approach, we want to avoid not only the analysis of the global behavior but also of the local behaviors of the components. Instead, we consider very small parts of the local behaviors called port protocols that suffice to verify properties.

  19. Porting and redesign of Geotool software system to Qt

    Science.gov (United States)

    Miljanovic Tamarit, V.; Carneiro, L.; Henson, I. H.; Tomuta, E.

    2016-12-01

    Geotool is a software system that allows a user to interactively display and process seismoacoustic data from International Monitoring System (IMS) station. Geotool can be used to perform a number of analysis and review tasks, including data I/O, waveform filtering, quality control, component rotation, amplitude and arrival measurement and review, array beamforming, correlation, Fourier analysis, FK analysis, event review and location, particle motion visualization, polarization analysis, instrument response convolution/deconvolution, real-time display, signal to noise measurement, spectrogram, and travel time model display. The Geotool program was originally written in C using the X11/Xt/Motif libraries for graphics. It was later ported to C++. Now the program is being ported to the Qt graphics system to be more compatible with the other software in the International Data Centre (IDC). Along with this port, a redesign of the architecture is underway to achieve a separation between user interface, control, and data model elements, in line with design patterns such as Model-View-Controller. Qt is a cross-platform application framework that will allow geotool to easily run on Linux, Mac, and Windows. The Qt environment includes modern libraries and user interfaces for standard utilities such as file and database access, printing, and inter-process communications. The Qt Widgets for Technical Applications library (QWT) provides tools for displaying standard data analysis graphics.

  20. Competitiveness in a Multipolar Port System: Striving for Regional Gateway Status in Northeast Asia

    Directory of Open Access Journals (Sweden)

    Sihyun Kim

    2016-06-01

    Full Text Available The structure of competitiveness between hub ports in the multipolar Northeast Asian system will determine which ports achieve regional gateway status. A survey instrument to assess 21 measurement items generated 203 responses from Shanghai, Hong Kong and Busan. Exploratory factor analysis revealed a valid and reliable competitiveness construct underpinning 19 measurement scales and a four-factor model incorporating availability, operational efficiency, port costs and service quality. Differences in factor importance revealed that success as a regional gateway port depends on a port area developing strategically into a multi-functional business centre. The model offers a management tool to guide future port improvement.

  1. Vectorization, parallelization and porting of nuclear codes on the VPP500 system (porting). Progress report fiscal 1996

    Energy Technology Data Exchange (ETDEWEB)

    Nemoto, Toshiyuki [Fujitsu Ltd., Tokyo (Japan); Kawasaki, Nobuo; Tanabe, Hidenobu [and others

    1998-01-01

    Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. These results are reported in 3 parts, i.e., the vectorization part, the parallelization part and the porting part. In this report, we describe the porting. In this porting part, the porting of reactor safety analysis code RELAP5/MOD3.2 and RELAP5/MOD3.2.1.2, nuclear data processing system NJOY and 2-D multigroup discrete ordinate transport code TWOTRAN-II are described. And also, a survey for the porting of command-driven interactive data analysis plotting program IPLOT are described. In the parallelization part, the parallelization of 2-Dimensional relativistic electromagnetic particle code EM2D, Cylindrical Direct Numerical Simulation code CYLDNS and molecular dynamics code for simulating radiation damages in diamond crystals DGR are described. And then, in the vectorization part, the vectorization of two and three dimensional discrete ordinates simulation code DORT-TORT, gas dynamics analysis code FLOWGR and relativistic Boltzmann-Uehling-Uhlenbeck simulation code RBUU are described. (author)

  2. 33 CFR 149.415 - What are the requirements for a fire main system on a manned deepwater port?

    Science.gov (United States)

    2010-07-01

    ... fire main system on a manned deepwater port? 149.415 Section 149.415 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: DESIGN... are the requirements for a fire main system on a manned deepwater port? (a) Each pumping platform...

  3. An Investigation of Interrater Reliability for the Rorschach Performance Assessment System (R-PAS) in a Nonpatient U.S. Sample.

    Science.gov (United States)

    Kivisalu, Trisha M; Lewey, Jennifer H; Shaffer, Thomas W; Canfield, Merle L

    2016-01-01

    The Rorschach Performance Assessment System (R-PAS) aims to provide an evidence-based approach to administration, coding, and interpretation of the Rorschach Inkblot Method (RIM). R-PAS analyzes individualized communications given by respondents to each card to code a wide pool of possible variables. Due to the large number of possible codes that can be assigned to these responses, it is important to consider the concordance rates among different assessors. This study investigated interrater reliability for R-PAS protocols. Data were analyzed from a nonpatient convenience sample of 50 participants who were recruited through networking, local marketing, and advertising efforts from January 2013 through October 2014. Blind recoding was used and discrepancies between the initial and blind coders' ratings were analyzed for each variable with SPSS yielding percent agreement and intraclass correlation values. Data for Location, Space, Contents, Synthesis, Vague, Pairs, Form Quality, Populars, Determinants, and Cognitive and Thematic codes are presented. Rates of agreement for 1,168 responses were higher for more simplistic coding (e.g., Location), whereas agreement was lower for more complex codes (e.g., Cognitive and Thematic codes). Overall, concordance rates achieved good to excellent agreement. Results suggest R-PAS is an effective method with high interrater reliability supporting its empirical basis.

  4. A port-Hamiltonian approach to visual servo control of a pick and place system

    NARCIS (Netherlands)

    Dirksz, Daniel A.; Scherpen, Jacquelien M.A.

    2012-01-01

    In this paper we take a port-Hamiltonian approach to address the problem of image-based visual servo control of a pick and place system. We realize a closed-loop system, including the nonlinear camera dynamics, which is port-Hamiltonian. Although the closed-loop system is nonlinear, the resulting

  5. Fano resonance formula for lossy two-port systems.

    Science.gov (United States)

    Yoon, Jae Woong; Magnusson, Robert

    2013-07-29

    We provide a modified Fano resonance formula applicable to dissipative two-port resonance systems. Based on a generic coupled-resonator model, the formula embodies loss-related correction terms and fundamental resonance parameters that can be determined by an analytic method or experimentally as opposed to finding phenomenological parameters by fitting to numerical results. The theory applies physically meaningful resonance parameters including resonance frequency, total decay rates, and partial radiation probabilities. For example, it shows that the classic Fano shape parameter q is given directly in terms of the phase difference between the resonant and non-resonant transmission pathways. Our new resonance formula quantitatively expresses the resonance spectra pertaining to modal nanophotonic and surface-plasmonic thin-film structures as verified by comparing with exact numerical models.

  6. Sustainability and the Spanish port system. Analysis of the relationship between economic and environmental indicators.

    Science.gov (United States)

    Laxe, Fernando González; Bermúdez, Federico Martín; Palmero, Federico Martín; Novo-Corti, Isabel

    2016-12-15

    Research into the methodological development of alternative systems of sustainability measures is recent. In understanding sustainable development in a multi-dimensional sense, one of the most significant advances was the construction of Synthetic Indexes, applicable to different spatial spheres or to organisations, businesses, institutions, etc. The Spanish port system of general interest comprises 46 ports integrated in 28 Port Authorities, which in 2014 moved 482,000,000t of goods and more than 28 million passengers. This gives an idea of its importance for the Spanish economy. Using a derivation of the procedure used to calculate the Port Sustainability Synthetic Index, in this research the analysis of the relationship that exists between the findings obtained for the economic and environmental dimensions is used. This enables the existence of links between ports and economic and environmental indicators for a sample of 16 Port Authorities of Spain to be verified. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Composition of Dirac structures and control of Port-Hamiltonian systems

    NARCIS (Netherlands)

    van der Schaft, Arjan; Cervera, J.; Gilliam, D.S.; Rosenthal, J.

    2002-01-01

    Key feature of Dirac structures (as opposed to Poisson or symplectic structures) is the fact that the standard composition of two Dirac structures is again a Dirac structure. In particular this implies that any power-conserving interconnection of port-Hamiltonian systems is a port-Hamiltonian system

  8. Port Hamiltonian Formulation of Infinite Dimensional Systems II. Boundary Control by Interconnection

    NARCIS (Netherlands)

    Macchelli, Alessandro; Schaft, Arjan J. van der; Melchiorri, Claudio

    2004-01-01

    In this paper, some new results concerning the boundary control of distributed parameter systems in port Hamiltonian form are presented. The classical finite dimensional port Hamiltonian formulation of a dynamical system has been generalized to the distributed parameter and multi-variable case by

  9. Programmable Logic Device (PLD) Design Description for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio

    Science.gov (United States)

    Shalkhauser, Mary Jo W.

    2017-01-01

    The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. At the conclusion of the development, the software and hardware description language (HDL) code was delivered to JSC for their use in their iPAS test bed to get hands-on experience with the STRS standard, and for development of their own STRS Waveforms on the now STRS compliant platform.The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx ML605 Virtex-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek eBox 620-110-FL) running the Ubuntu 12.4 operating system. Figure 1 shows the RIACS platform hardware. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications.The purpose of this document is to describe the design of the HDL code for the FPGA portion of the iPAS STRS Radio particularly the design of the FPGA wrapper and the test waveform.

  10. Functional Differentiation and Sustainability: A New Stage of Development in the Chinese Container Port System

    Directory of Open Access Journals (Sweden)

    Liehui Wang

    2017-02-01

    Full Text Available Adjacent ports played a significant role in the evolution of the port system. In our study, we selected five pairs (i.e., Dalian–Yingkou, Qingdao–Yantai, Shanghai–Ningbo, Xiamen–Quanzhou, and Shenzhen–Guangzhou of the most important adjacent ports in China to reveal the recent trend of China unique port system development; how and why will port system development be de-concentrated; and integrate the conceptual modal into in-depth analysis. The major findings are as follows: (1 There is functional differentiation in adjacent ports. To some big ports’ sustainability, they focus on foreign trade while other small ports, in order to achieve sustainable development, they focus on domestic trade; (2 First-mover advantage and dislocation competition is a mechanism of China ports functional differentiation; (3 Shanghai and Ningbo are unique in that both ports are similarly focused on foreign trade because they both have deep-water harbors, excellent geographical location, export-oriented hinterland economy, and close foreign investment relationships.

  11. Revealing the Linkage Network Dynamic Structures of Chinese Maritime Ports through Automatic Information System Data

    Directory of Open Access Journals (Sweden)

    Hongchu Yu

    2017-10-01

    Full Text Available Marine economic cooperation has emerged as a major theme in this era of globalization; hence, maritime network connectivity and dynamics have attracted more and more attention. Port construction and maritime route improvements increase maritime trade and thus facilitate economic viability and resource sustainability. This paper reveals the regional dimension of inter-port linkage dynamic structure of Chinese maritime ports from a complex multilayer perspective that is meaningful for strategic forecasting and regional long-term economic development planning. In this research, Automatic Information System (AIS-derived traffic flows were used to construct a maritime network and subnetworks based on the geographical locations of ports. The linkage intensity between subnetworks, the linkage tightness within subnetworks, the spatial isolation between high-intensity backbones and tight skeleton networks, and a linkage concentration index for each port were calculated. The ports, in turn, were analyzed based on these network attributes. This study analyzed the external competitiveness and internal cohesion of each subnetwork. The results revealed problems in port management and planning, such as unclear divisions in port operations. More critically, weak complementary relationships between the backbone and skeleton networks among the ports reduce connectivity and must be strengthened. This research contributes to the body of work supporting strategic decision-making for future development.

  12. Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio User's Guide -- Advanced Exploration Systems (AES)

    Science.gov (United States)

    Roche, Rigoberto; Shalkhauser, Mary Jo Windmille

    2017-01-01

    The Integrated Power, Avionics and Software (IPAS) software defined radio (SDR) was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RAICS) platform, for radio development at NASA Johnson Space Center. Software and hardware description language (HDL) code were delivered by NASA Glenn Research Center for use in the IPAS test bed and for development of their own Space Telecommunications Radio System (STRS) waveforms on the RAICS platform. The purpose of this document is to describe how to setup and operate the IPAS STRS Radio platform with its delivered test waveform.

  13. Tools for an integrated systems approach to sustainable port city planning

    Directory of Open Access Journals (Sweden)

    Gilles Morel

    2013-12-01

    Full Text Available Large port cities like Shanghai, Amsterdam and Rio de Janeiro are key cogwheels in international logistics and transport networks but also serve as showcases for the rest of the world; as such, they constitute strategic assets for the host country´s economy and international influence. Historically, a city and its port often developed independently, through sometimes contradictory or even confrontational policies. Today, the growing number of usage disputes over increasingly coveted coastal areas is prompting local managers to incorporate urban and port-related issues in overarching planning programs. In particular, planning of the sea front and the buffer zone between the port and the city must contribute decisively to the deployment of more effective, cleaner transport services for the port city as a whole. In general, one of the key global challenges for planners and decision-makers consists in integrating sustainable development goals (environmental and social components, as well as the stimulation of industrial competitiveness into urban planning. In this context the PHEBUS research group has initiated an international program of research to develop innovative methods and tools that can help territorial stakeholders to design, evaluate, compare and ultimately choose development scenarios for the future of their port cities. The main themes are addressed via a multidisciplinary systems approach on the scale of a coastal urban area with an industrial and port complex. In particular, the themes include sea front planning, the city-port interface, energy optimization (e.g. the introduction and sharing of renewable energies, risk resilience, climate change and multimodal, clean transport.

  14. Management of venous port systems in oncology: a review of current evidence.

    Science.gov (United States)

    Vescia, S; Baumgärtner, A K; Jacobs, V R; Kiechle-Bahat, M; Rody, A; Loibl, S; Harbeck, N

    2008-01-01

    Over the last decades, many changes have occurred in oncology with new chemotherapy combinations and more complex application schemes becoming available. Central venous catheters and implantable venous port systems have become widely used and have facilitated the problem of vascular access. However, important complications are associated with permanent central venous catheters. This review summarizes evidence on venous port system use published in Medline up to February 2007. Moreover, recent guidelines for the prevention and management of catheter-related infections issued by the Infectious Diseases Society of America, the American College of Critical Care Medicine, the Society for Healthcare Epidemiology of America, the Center for Disease Control and Prevention, Atlanta, and the Infectious Diseases Working Party of the German Society of Hematology and Oncology are included. Sterile precautions are essential when implanting and accessing port systems. Infections must be treated with adequate antimicrobial therapy. Catheter-related thromboembolic complications were found at a rate of 12-64% in retrospective studies. Five current clinical trials investigated the effect of prophylactic anticoagulation with either low molecular weight heparin or warfarin in cancer patients with central venous devices. On the basis of these results, routine anticoagulation cannot be recommended. This article reviews the current literature on long-term complications of venous port systems, focusing on infection and thrombosis. In addition, it summarizes the evidence regarding routine maintenance of port systems in follow-up care.

  15. Asymptotic Stabilization of Non-holonomic Port-controlled Hamiltonian Systems

    DEFF Research Database (Denmark)

    Sørensen, Mathias Jesper; Bendtsen, Jan Dimon; Andersen, Palle

    2004-01-01

    A novel method for asymptotic stabilization of a class of non-holonomic systems is presented. The method is based on the port-controlled Hamiltonian description of electro-mechanical systems. The general system is augmented with so-called kinematic inputs, thus representing a special class of mob...

  16. ACUTE PHASE OF SYSTEMIC INFLAMMATORY RESPONSE FOLLOWING A SINGLE-PORT LAPAROSCOPIC CHOLECYSTECTOMY

    Directory of Open Access Journals (Sweden)

    A. V. Alekberzade

    2015-01-01

    Full Text Available Early course of acute systemic inflammatory response after surgical intervention was traced for sixty-four patients with chronic calculous cholecystitis following a laparoscopic cholecystectomy (LCE. The patients were classified in 2 groups dependent on the surgery mode. The main group included 32 patients after single-port LCE, and controls that underwent four-port LCE (n = 32. Peripheral blood samples were taken 2 h before intervention, as well as 6, 24, and 48 h after surgical treatment. of Alpha-1-antitrypsin (A1AT, C-reactive protein, TNFα and IL-1β levels were measured in the specimens. For A1AT, we have not found any significant differences between the baseline and post-surgery levels, both in main and control groups. The intergroup comparisons showed a statistically significant increase in A1AT levels 24 h after the 4-port LCE. The patients subjected to single-port LCE, exhibited similar pre- and post-surgery levels of C-reactive protein. In the control group, its level proved to be statistically higher against initial values 6 h after the surgery. Comparing the both groups, C-reactive protein was found to be significantly increased in controls 6 и 24 h after surgery.The post-op TNFα levels after the single-port LCE tended to increase, as compared to the baseline values. A statistical increase of TNF levels over initial values was noted 24 h after the 4-port LCE. Upon the intergroup comparisons, a significant TNF increase was revealed 24 following the 4-port LCE. IL-1β levels in the main group did not differ between the pre- and post-surgical period. However, its statistically significant increase to the initial values was revealed in controls 24 h after surgery. A comparison for IL-1β levels between the 2 groups has shown its significant elevation 24 h after the 4-port LCE. These data allow to conclude that a systemic inflammatory response as assessed by acute phase proteins in patients after a single-port LCE, is

  17. Infection of an intravenous port system with Metschnikowia pulcherrima Pitt et Miller.

    Science.gov (United States)

    Mohl, W; Lerch, M M; Klotz, M; Freidank, H; Zeitz, M

    1998-11-01

    A patient with short bowel syndrome as a consequence of multiple intestinal resections for Crohn's disease, had a port system implanted to improve her nutritional status. One year later she presented with fever, weakness and nighttime sweating. Metschnikowia pulcherrima Pitt et Miller was grown in blood cultures from the port system. After antifungal chemotherapy using fluconazole and removal of the implant, the patient's condition improved markedly and her fever and sweating disappeared. We conclude that Metschnikowia pulcherrima can turn into a human pathogen in patients with indwelling catheters for parenteral nutrition. Chemotherapy with fluconazole and, whenever possible, removal of the implant, appear to be adequate treatment.

  18. Towards Ocean Grazer's Modular Power Take-Off System Modeling : A Port-Hamiltonian Approach

    NARCIS (Netherlands)

    Barradas-Berglind, J. J.; Muñoz Arias, M.; Wei, Y.; Prins, W.A.; Vakis, A.I.; Jayawardhana, B.; Dochain, Denis; Henrion, Didier; Peaucelle, Dimitri

    This paper presents a modular modeling framework for the Ocean Grazer's Power Take-Off (PTO) system, which operates as an array of point-absorber type devices connected to a hydraulic system. The modeling is based on the port-Hamiltonian (PH) framework that enables energy-based analysis and control

  19. Demand modeling of innovative transport system PRT at the Rotterdam port area

    NARCIS (Netherlands)

    Li, H.; Chen, Y.; Li, J.; Zuylen, H.J. van; Arem, B. van

    2010-01-01

    Demand modeling for a newly built transit system is a major issue for the feasibility study. The complexity for such demand modeling stems from the complicated multi-modal trip making by travelers. This paper proposes to build an innovative transit system PRT in the east port area of Rotterdam to

  20. Control by Interconnection and Standard Passivity-Based Control of Port-Hamiltonian Systems

    NARCIS (Netherlands)

    Ortega, Romeo; Schaft, Arjan van der; Castaños, Fernando; Astolfi, Alessandro

    2008-01-01

    The dynamics of many physical processes can be suitably described by Port-Hamiltonian (PH) models, where the importance of the energy function, the interconnection pattern and the dissipation of the system is underscored. To regulate the behavior of PH systems it is natural to adopt a

  1. A Three-Port Topology Comparison for a Low Power Stand-Alone Photovoltaic System

    DEFF Research Database (Denmark)

    Mira Albert, Maria del Carmen; Knott, Arnold; Andersen, Michael A. E.

    2014-01-01

    Three-port converter (TPC) topologies for renewable energy systems aim to provide higher efficiency and power density than conventional cascaded structures. This work proposes an analytical comparison of different TPC topologies for a photovoltaic LED lamp stand-alone system. A comparison using...

  2. "Obama system:" a new easy, safe, and economical technique for laparoscopic single-port surgery.

    Science.gov (United States)

    Soma, T; Sugano, M; Ito, T; Kiguchi, G; Tanaka, T; Hattori, Y

    2012-02-01

    Various approaches to laparoscopic single-site surgery (LESS) have been developed to reduce pain and other complications, promote recovery, and improve cosmetic outcomes, particularly relative to conventional open or laparoscopic surgery. Three-port procedures for LESS have been reported to be superior to single-port access, but they usually require expensive, technically sophisticated instruments. To avoid these problems, we have developed a modified procedure for performing LESS with a single port, referred to as the "Obama system." From January 2009 through December 2010, we performed laparoscopic cholecystectomy (LC) in 61 patients. Conventional LC with three ports was performed in 39 patients, LESS with a SILS Port was performed in 4 patients, and modified LESS was performed using the Obama system in 18 patients. The operative results were compared. LC was successfully completed in all 61 patients, with no postoperative complications. The mean operating time was 102.3 min (C-reactive protein [CRP] ≤ 2) and 160.1 min (CRP > 2) in the 39 patients who underwent conventional LC, 108.3 min (CRP ≤ 2) in the 4 patients who underwent LESS with a SILS Port, and 116.5 min (CRP ≤ 2) and 186.5 min (CRP > 2) in the 18 patients who underwent LESS using the Obama system. No morbidity or mortality was associated with any technique. The Obama system is easier to use and more efficient and reliable than any other technique currently available for LESS. This system is expected to greatly contribute to the further development and wider acceptance of LESS. © 2011 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and Blackwell Publishing Asia Pty Ltd.

  3. Criteria System of Emergency Situations Risks Assessment in the Baltic Sea Ports

    Directory of Open Access Journals (Sweden)

    Bazaras Darius

    2017-12-01

    Full Text Available This paper reviews the principles of transportation risk assessment in the Baltic Sea ports and hinterland. The essential steps of assessment are the identification of primary criterions, the determining the underlying criterion groups and quantitative assessment of international environment indicators and nature, infrastructure indicators and organizational indicators on the basis of the multiple-criteria evaluation methods. Designed system of criteria creates a possibility for objective evaluation of risk management processes and allows planning objectively long-term risk management strategy in the ports according to certain economic development circumstances.

  4. Port-Based Modeling and Simulation of Mechanical Systems With Rigid and Flexible Links

    NARCIS (Netherlands)

    Macchelli, A.; Melchiorri, C.; Stramigioli, Stefano

    2009-01-01

    In this paper, a systematic procedure for the defi- nition of the dynamical model in port-Hamiltonian form of me- chanical systems is presented as the result of the power-conserving interconnection of a set of basic components (rigid bodies, flexible links, and kinematic pairs). Since rigid bodies

  5. Energy Shaping of Port-Hamiltonian Systems by Using Alternate Passive Input-Output Pairs

    NARCIS (Netherlands)

    Venkatraman, A.; Schaft, A. van der

    2010-01-01

    We consider port-Hamiltonian systems with dissipation (PHSD) whose underlying geometric structure is represented as the composition of a Dirac and a resistive structure. We show how the choice of a new passive input-output pair for a PHSD is reflected in a new Dirac structure. We define a general

  6. Analysis of the role of port labour systems and reforms on the ...

    African Journals Online (AJOL)

    Design/Methodology/Approach -The study draws heavily on existing ... to the other and benchmarking on the success of the systems lays the foundation for the ... can play in the performance of a port, is presented using Ghana as a case study.

  7. Reliability assessment of Port Harcourt 33/11kv Distribution System ...

    African Journals Online (AJOL)

    Consumers of electrical energy expect a network to support their apparatuses with continuous and reliable supply.This makes reliability studies an important task besides all the other analyses required for assessing the system performance. The paper presents an analytical approach in the reliability assessment of the Port ...

  8. Database specification for the Worldwide Port System (WPS) Regional Integrated Cargo Database (ICDB)

    Energy Technology Data Exchange (ETDEWEB)

    Faby, E.Z.; Fluker, J.; Hancock, B.R.; Grubb, J.W.; Russell, D.L. [Univ. of Tennessee, Knoxville, TN (United States); Loftis, J.P.; Shipe, P.C.; Truett, L.F. [Oak Ridge National Lab., TN (United States)

    1994-03-01

    This Database Specification for the Worldwide Port System (WPS) Regional Integrated Cargo Database (ICDB) describes the database organization and storage allocation, provides the detailed data model of the logical and physical designs, and provides information for the construction of parts of the database such as tables, data elements, and associated dictionaries and diagrams.

  9. Regulation and input disturbance suppression for port-controlled Hamiltonian systems

    NARCIS (Netherlands)

    Gentili, L.; Astolfi, A.; van der Schaft, Arjan; Gordillo, F.

    2003-01-01

    In this paper the output feedback regulation problem for port-controlled Hamiltonian systems (PCHS) is addressed. Following the nonlinear output regulation theory, the regulator which solves the problem is given by a parallel connection of two subcontrollers: an internal model unit and a regulator

  10. Alternative system design concepts for the ITER core CXRS upper port plug front end

    Energy Technology Data Exchange (ETDEWEB)

    Krimmer, A., E-mail: A.Krimmer@fz-juelich.de [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany); Klinkhamer, F. [TNO Science and Industry, partner in ITER-NL, P.O. Box 155, 2600 AD Delft (Netherlands); Biel, W. [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany); Hawkes, N. [Association EURATOM/CCFE, OX14 3DB, Abingdon (United Kingdom); Kiss, G. [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany); Koning, J.F. [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, partner in the Trilateral Euregio Cluster and ITER-NL, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands); Krasikov, Yu.; Neubauer, O. [Institut fuer Energieforschung - Plasmaphysik, Forschungszentrum Juelich Gmbh, Association EURATOM-FZJ, member of Trilateral Euregio Cluster, 52425 Juelich (Germany)

    2011-10-15

    Highlights: > System design for the core CXRS diagnostic port plug for ITER is investigated. > Dependencies of the sub-systems are given. > Overall system lifetime and recent mechanical changes are taken into account. > System configurations are derived for the current ITER design. - Abstract: The upper port no. 3 in ITER will be used by the core Charge Exchange Recombination Spectroscopy (core CXRS) to channel out light from the inside of the vacuum vessel. Recent research about the lifetime of the first two mirrors and changes in the upper port plug geometry initiated further investigations into possible alternative system design concepts. Two new variants of the optical system were chosen for further investigation. The different sub-systems of core CXRS such as optical system, retractable tube and shutter are introduced together with their impact on the system design and their interactions. Space constraints originating from the envelope of the UPP and requirements emerging from the ITER environment such as remote handling and other maintenance considerations are also included in the investigation. Alternative system concepts taking the constraints into account are presented and discussed. Implications for further design work on the subsystems are derived from the results.

  11. [A novel serial port auto trigger system for MOSFET dose acquisition].

    Science.gov (United States)

    Luo, Guangwen; Qi, Zhenyu

    2013-01-01

    To synchronize the radiation of microSelectron-HDR (Nucletron afterloading machine) and measurement of MOSFET dose system, a trigger system based on interface circuit was designed and corresponding monitor and trigger program were developed on Qt platform. This interface and control system was tested and showed stable operate and reliable work. This adopted serial port detect technique may expand to trigger application of other medical devices.

  12. Test Report for Cricket Radiation Detection System Used In EPA Port Installations

    Energy Technology Data Exchange (ETDEWEB)

    Shourbaji, AA

    2004-08-11

    Oak Ridge National Laboratory conducted field radiological measurements at two port locations at the request of the Environmental Protection Agency (EPA). The radiological measurements were performed on five radiation detection systems at the port of Darrow, Louisiana and three systems at the port of Charleston, South Carolina. Darrow was visited on January 20-23, 2004 and Charleston on May 25, 2004. All tested systems are designed to detect radioactive material that might be present in scrap metals as the scrap is being unloaded from ships. All eight systems are commercially known as the Cricket and manufactured by RAD/COMM Systems. Each radiation detection system consists of a detector with two channels and a wireless transmitter, both mounted on the grapple, and a controller located in the crane cab. The cranes at both locations are operated by the Cooper T. Smith Company. The purpose of the radiological measurements was to evaluate the performance of the radiation detection systems in terms of their ability to detect elevated radiation levels, and to develop a routine testing method for all EPA Cricket systems.

  13. Effectiveness of a Barge-Based Ballast Water Treatment System for Multi-Terminal Ports

    Directory of Open Access Journals (Sweden)

    Lovro Maglić

    2015-10-01

    Full Text Available The paper presents outcomes of the discrete event simulation of the ballast water management in a multi-terminal port. The simulation includes ship’s manoeuvring, cargo and ballast operations and a barge-based ballast water treatment system operating within all terminal areas. The barge-based ballast water treatment system is used by ships unable to use their own equipment, not equipped with an appropriate ballast treatment system or non-compliant with the Ballast Water Management (BWM Convention 2004 for whatever reason. The main goal is to estimate the productivity and cost effectiveness of such systems as an option to support ships not able to comply with the BWM Convention, once it enters into force. The model was built and tested in Arena simulation software. Process parameters are based on real traffic data for the port of Rijeka. The results indicate that barge-based ballast treatment facility will be heavily underutilized, and that such systems are cost-effective only in ports where large volumes of ballast water need to be delivered to shore treatment systems.

  14. ITER Upper Port Plug handling cask system assessment and design proposals

    Energy Technology Data Exchange (ETDEWEB)

    Pustjens, J.-W., E-mail: j.w.pustjens@gmail.com [Technische Universiteit Eindhoven, P.O. Box 513, 5600 MB Eindhoven (Netherlands); Friconneau, J.-P. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul-lez-Durance Cedex (France); Heemskerk, C.J.M. [Heemskerk Innovative Technology, Merelhof 2, 2172 HZ Sassenheim (Netherlands); Koning, J.F. [FOM-Institute for Plasma Physics Rijnhuizen, Association EURATOM-FOM, partner in the Trilateral Euregio Cluster and ITER-NL, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands); Martins, J.-P. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul-lez-Durance Cedex (France); Rosielle, P.C.J.N.; Steinbuch, M. [Technische Universiteit Eindhoven, P.O. Box 513, 5600 MB Eindhoven (Netherlands)

    2011-10-15

    The current design of the ITER cask for Upper Port Plugs has been evaluated. Careful reduction of the number of mechanical degrees of freedom is an opportunity to relax the tolerances in the design, resulting in cost reduction and reliability increase. A new kinematical design for the tractor module has a higher stiffness to weight ratio, reduces actuator forces by a factor four and minimizes cross-talk between lift and rotation motion. Non-cantilevered handling is recommended to reduce wheel loads on the tractor by a factor six and to simplify guidance. At the system level the tubular guide (TG) is proposed, a semi-permanent 3.5 m long tube which is an extension of the Upper Port. Cask docking is simplified and the risk of the cask tilting is prevented. Redesigning the system concept is recommended and the TG looks promising. Since a system level redesign impacts the external interfaces, overall feasibility has to be investigated.

  15. Simulation-Based Planning and Control of Transport Flows in Port Logistic Systems

    Directory of Open Access Journals (Sweden)

    Antonio Diogo Passos Lima

    2015-01-01

    Full Text Available In highly dynamic and uncertain transport conditions, transport transit time has to be continuously monitored so that the service level is ensured at a proper cost. The aim of this research is to propose and to test a procedure which allows an agile planning and control of transport flows in port logistic systems. The procedure couples an agent-based simulation and a queueing theory model. In this paper, the transport scheduling performed by an agent at the intermodal terminal was taken into consideration. The decision-making agent takes into account data which is acquired in remote points of the system. The obtained results indicate the relevance of continuously considering, for the transport planning and control, the expected transit time and further waiting times along port logistic systems.

  16. ORGANIZATION AND IMPLEMENTATION OF INTEGRATED MANAGEMENT SYSTEM PROCESSES - CRUISE PORT DUBROVNIK

    Directory of Open Access Journals (Sweden)

    Ivona Vrdoljak Raguz

    2012-01-01

    Full Text Available World cruise market is very dynamic and it is characterised by constant changes in offer and demand. Dubrovnik, as one of the leading port in the Mediterranean is faced with the problem of large concentrations of ships and passengers in a short period of time. Paper provides answers to the questions: how to manage cruise tourism in Dubrovnik? What are the guidelines for the further development of cruising in Dubrovnik? Modern ports management system must be organized and managed in a manner that will ensure the recognition requirements of stakeholders and their fulfilment. All this requires a more complex integrated management system, in which the requirements of quality management will be the basis, and requirements of environmental management needed an upgrade.

  17. Agile Port System Transition Support Transition Plan Development

    Science.gov (United States)

    2013-07-29

    appropria tunity  en the acquis ransfer  agre  T efforts.  ent with Defe ne gates, fun re appropria ortunities ar rocesses of d te.  This holis  to move con...National Laboratory (ORNL) with the Department of  Energy   (DOE) as a partner to develop a Travelocity unclassified version within the FACTS ONR...2) a smart networked secure trade corridor from the gateway  connected to (3) a smart inland or virtual node (and system operator like an  energy  grid

  18. Towards Ocean Grazer's Modular Power Take-Off System Modeling: A Port-Hamiltonian Approach

    OpenAIRE

    Barradas-Berglind, J. J.; Muñoz Arias, M.; Wei, Y; Prins, W.A.; Vakis, A. I.; Jayawardhana, B.

    2017-01-01

    This paper presents a modular modeling framework for the Ocean Grazer's Power Take-Off (PTO) system, which operates as an array of point-absorber type devices connected to a hydraulic system. The modeling is based on the port-Hamiltonian (PH) framework that enables energy-based analysis and control of the PTO system. Firstly, a modular model of a point-absorber hydraulic system, which represents the main building block of the PTO, is presented. The model consists of wave-mechanical and hydrau...

  19. Modeling integrated urban water systems in developing countries: case study of Port Vila, Vanuatu.

    Science.gov (United States)

    Poustie, Michael S; Deletic, Ana

    2014-12-01

    Developing countries struggle to provide adequate urban water services, failing to match infrastructure with urban expansion. Despite requiring an improved understanding of alternative infrastructure performance when considering future investments, integrated modeling of urban water systems is infrequent in developing contexts. This paper presents an integrated modeling methodology that can assist strategic planning processes, using Port Vila, Vanuatu, as a case study. 49 future model scenarios designed for the year 2050, developed through extensive stakeholder participation, were modeled with UVQ (Urban Volume and Quality). The results were contrasted with a 2015 model based on current infrastructure, climate, and water demand patterns. Analysis demonstrated that alternative water servicing approaches can reduce Port Vila's water demand by 35 %, stormwater generation by 38 %, and nutrient release by 80 % in comparison to providing no infrastructural development. This paper demonstrates that traditional centralized infrastructure will not solve the wastewater and stormwater challenges facing rapidly growing urban cities in developing countries.

  20. OPERATING SYSTEM FOR WIRELESS SENSOR NETWORKS AND AN EXPERIMENT OF PORTING CONTIKIOS TO MSP430 MICROCONTROLLER

    Directory of Open Access Journals (Sweden)

    Thang Vu Chien

    2012-07-01

    Full Text Available Wireless Sensor Networks (WSNs consist of a large number of sensor nodes, and are used for various applications such as building monitoring, environment control, wild-life habitat monitoring, forest fire detection, industry automation, military, security, and health-care. Each sensor node needs an operating system (OS that can control the hardware, provide hardware abstraction to application software, and fill in the gap between applications and the underlying hardware. In this paper, researchers present OS for WSNs and an experiment of porting contikiOS to MSP430 microcontroller which is very popular in many hardware platforms for WSNs. Researchers begin by presenting the major issues for the design of OS for WSNs. Then, researchers examine some popular operating systems for WSNs including TinyOS, ContikiOS, and LiteOS. Finally, researchers present an experiment of porting ContikiOS to MSP430 microcontroller. Wireless Sensor Networks (WSNs terdiri dari sejumlah besar sensor nodes, dan digunakan untuk berbagai aplikasi seperti pemantauan gedung, pengendalian lingkungan, pemantauan kehidupan habitat liar, deteksi kebakaran hutan, otomatisasi industri, militer, keamanan, dan kesehatan. Setiap sensor nodememerlukan sistem operasi (SO yang dapat mengontrol hardware, menyediakan abstraksi hardware untuk aplikasi perangkat lunak, dan mengisi kesenjangan antara aplikasi dan hardware. Dalam penelitian ini, peneliti menyajikan SO untuk WSNs dan percobaan dari port contikiOS untuk MSP430 mikrokontroler yang sangat populer di platformhardware untuk WSNs. Peneliti memulai dengan menghadirkan isu utama yaitu desain SO untuk WSNs. Lalu, penelitimemeriksa beberapa sistem operasi populer untuk WSNs, termasuk TinyOS, ContikiOS, dan LiteOS. Akhirnya penelitimenyajikan sebuah percobaan dari port ContikiOS untuk MSP430 mikrokontroler.

  1. New Futures for Older Ports: Synergistic Development in a Global Urban System

    Directory of Open Access Journals (Sweden)

    Joe Ravetz

    2013-11-01

    Full Text Available Port cities are on the front-line of a changing global urban system. There are problems from restructuring of trade, logistics and ship-building, creating economic dependency, social exclusion and cultural destruction. Meanwhile, there exists new opportunities in heritage tourism, cultural industries and ecological restoration, but these opportunities often have negative impacts. This paper addresses the question of how port cities can steer from negative to positive development paths and outcomes. It sets out a way of working with inter-connected economic, social, political and technological factors—a ‘synergistic’ approach to mapping of problems and design of policy responses. Looking at three contrasting examples of port cities—Liverpool, Dubai and Mauritius—we can compare the inter-connected dynamics of growth and decline. Then we can understand the inter-connected factors of successful regeneration and sustainable prosperity, not as linear ‘policy fixes’, but more like synergistic processes of learning, innovation and capacity building. These call for new models for creative innovation in social and community enterprise: cultural heritage both old and new; new social finance and investment; socio-ecological restoration with participative governance, etc. Such pathways and opportunities are now emerging in many different locations; this paper provides methods and tools to understand them and promote them.

  2. A data-management system using sensor technology and wireless devices for port security

    Science.gov (United States)

    Saldaña, Manuel; Rivera, Javier; Oyola, Jose; Manian, Vidya

    2014-05-01

    Sensor technologies such as infrared sensors and hyperspectral imaging, video camera surveillance are proven to be viable in port security. Drawing from sources such as infrared sensor data, digital camera images and processed hyperspectral images, this article explores the implementation of a real-time data delivery system. In an effort to improve the manner in which anomaly detection data is delivered to interested parties in port security, this system explores how a client-server architecture can provide protected access to data, reports, and device status. Sensor data and hyperspectral image data will be kept in a monitored directory, where the system will link it to existing users in the database. Since this system will render processed hyperspectral images that are dynamically added to the server - which often occupy a large amount of space - the resolution of these images is trimmed down to around 1024×768 pixels. Changes that occur in any image or data modification that originates from any sensor will trigger a message to all users that have a relation with the aforementioned. These messages will be sent to the corresponding users through automatic email generation and through a push notification using Google Cloud Messaging for Android. Moreover, this paper presents the complete architecture for data reception from the sensors, processing, storage and discusses how users of this system such as port security personnel can use benefit from the use of this service to receive secure real-time notifications if their designated sensors have detected anomalies and/or have remote access to results from processed hyperspectral imagery relevant to their assigned posts.

  3. Ford Partnership for Advanced Studies (Ford PAS)

    Science.gov (United States)

    Carrier, Cheryl

    2006-01-01

    This article features the Ford Partnership for Advanced Studies (Ford PAS) program that helps students gain knowledge about real-life business issues. Ford PAS is an educational program that combines college-prep academics with the critical 21st century skills students will need to succeed in college and in the workplace. The Ford PAS program uses…

  4. A system dynamics approach to intermodalism at the Port of Lewiston

    Energy Technology Data Exchange (ETDEWEB)

    Sebo, D.

    1996-08-01

    Intermodalism refers to interconnections among modes of transportation, e.g., road, rail, water, and air. Effective intermodal planning must cross boundaries between the public and private sectors as well as transportation modes. The development of an effective and efficient intermodal transportation system requires the identification of barriers to intermodal transportation and the investigation of the impact of proposed changes in infrastructure development, policies, regulations, and planning. A systems approach is necessary to adequately represent the interaction between the sometimes incompatible concerns of all modes and stakeholders. A systems dynamics model of intermodalism at the Port of Lewiston has been developed to highlight leverage points, hidden assumptions, second order effects resulting from feedback loops and system drivers. The purpose of this document is to present the results of the system dynamics model work.

  5. Principal Ports

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Principal Ports are defined by port limits or US Army Corps of Engineers (USACE) projects, these exclude non-USACE projects not authorized for publication. The...

  6. PAs: Public awareness and the popular media.

    Science.gov (United States)

    Carter, Reginald D; Ballweg, Ruth

    2017-07-01

    From the very beginning, popular media has played an essential role in driving public awareness and recognition of physician assistants (PAs) as major contributors to healthcare. But for PAs, popular media can be a double-edged sword. Over time, the roles of PAs have evolved from bit players to leading characters on television medical dramas. Even so, on some occasions, the roles of PAs have been marginalized and misrepresented. In the future, the PA profession will need to remain vigilant about how PAs are portrayed in the popular media and must learn how to use the full benefit of the media to promote the profession's diversity, flexibility, collegiality, and civic-mindedness.

  7. A history of US Army PAs.

    Science.gov (United States)

    Chalupa, Robyn L; Marble, W Sanders

    2017-11-01

    The US military has a long tradition of using physician assistants (PAs). The Army began using PAs in 1971 in an effort to supplement the physicians and surgeons in the medical corps. As their numbers grew, PAs gradually replaced general medical officers assigned to battalions. Later, specialty positions developed in aviation medicine, orthopedics, and emergency medicine. The need for a PA serving as an adviser in the major commands slowly developed at all levels of leadership. In 2015, the Army removed limitations on female PAs assigned to combat units. PAs lead in tactical and clinical settings, filling command roles, senior clinical positions, and administrative leadership roles.

  8. Wave Energy Exploitation System Integrated in the Coastal Structure of a Mediterranean Port

    Directory of Open Access Journals (Sweden)

    Stefania Naty

    2016-12-01

    Full Text Available A feasibility study for installing Wave Energy Converters (WECs in a Mediterranean port is presented here. The final aim is to evaluate the possibility of building a green touristic infrastructure in a site having ordinary wave energy. In particular, the site of interest is Giardini Naxos, which is located in the northern Ionian coast of the island of Sicily (Italy. A preliminary estimation of the available energy has been carried out. The chosen type of WEC device is the Oscillating Water Column (OWC system, which is found here to allow for good integration with the vertical breakwater needed for the extension of the existing port. Its feasibility is evaluated from the structural and economic point of view. Towards this aim, the system is tested in the laboratory for estimating the reflection coefficients and the pressures on the structure, which allow us to carry out the optimization of the OWC breakwater. Furthermore, the air turbine noise is estimated and an attenuation chamber is designed to reduce such noise to within acceptable levels. The economic feasibility study allows for an evaluation of the recuperation period of the investment, which is slightly less than the service life of the WEC device.

  9. Petri Net Approach of Collision Prevention Supervisor Design in Port Transport System

    Directory of Open Access Journals (Sweden)

    Danko Kezić

    2007-09-01

    Full Text Available Modern port terminals are equipped with various localtransport systems, which have the main task to transport cargobetween local storehouses and transport resources (ships,trains, trucks in the fastest and most efficient way, and at thelowest possible cost. These local transport systems consist offully automated transport units (AGV- automatic guided vehiclewhich are controlled by the computer system. The portcomputer system controls the fully automated transport units inthe way to avoid possible deadlocks and collisions betweenthem. However, beside the fully automated local transportunits, there are human operated transport units (fork-lifttrucks, cranes etc. which cross the path oftheAGVfrom timeto time. The collision of human operated transp011 unit andA GV is possible due to human inattention. To solve this problem,it is necesswy to design a supe1vismy control system thatcoordinates and controls both human driven transport unit andA G V In other words, the human-machine interactions need tobe supen·ised. The supen•ising system can be realized in the waythat the port terminal is divided into zones. Vehicle movementsare supen•ised by a video system which detects the moving ofparticular l'ehicles as a discrete event. Based on detected events,dangerous moving of certain vehicles is blocked by the supe1visi11gsystem. The paper considers the design of collision preventionsupen•isor by using discrete event dynamic themy. The portterminal is modeled by using ordi1za1y Petri nets. The design ofcollision prevention supe1visor is cmTied out by using the P-inl'ariantmethod. The verification of the supervisor is done bycomputer simulation.

  10. JPCam: Status of the 1.2Gpixel camera for the J-PAS survey.

    Science.gov (United States)

    Taylor, Keith; Marín-Franch, Antonio; Santoro, Fernando; Mendes de Oliveira, Claudia; Dupke, Renato

    2015-08-01

    JPCam is a 14-CCD mosaic camera, using the new e2v 9k-by-9k, 10 micron pixel detectors, to be deployed on the JST/T250, a dedicated 2.55m wide-field telescope at the OAJ (Observatorio Astrofísico de Javalambre) in Teruel, Spain. The camera is designed to perform the J-PAS, a BAO survey of the northern sky. The J-PAS survey strategy will use 59 filters, 56 relatively narrow-band (14.5nm) filters equi-spaced between 350 and 1000nm plus 3 broad-band filters to achieve unprecedented photometric red-shift accuracies for faint galaxies over 8000 square degrees of sky. The cryostat, detector mosaic and read electronics is being supplied by e2v. Each science detector is read from 16 ports simultaneously, allowing read times of 14s with a typical read noise of 5e- (rms). The JPCam focal plane will be complemented with 4 autoguiding and 8 wavefront sensing CCDs. Image quality over the whole CCD mosaic will be maintained by applying the required, close loop, focus, tilt and rotation adjustments to the focal plane through the JPCam hexapod actuator system, manufactured by NTE-Sener. The filter unit has been designed to admit 5 filter trays, each mounting 14 filters corresponding to the 14 CCDs of the mosaic. Each CCD will view only its corresponding filter avoiding optical cross-talk from their neighbors. With this configuration, JPCam will cover 4.7 square degrees with a plate scale of 0.2267 arcsec/pix and will allow all the J-PAS filters to be permanently installed on the camera. The massive 525mm aperture shutter is supplied by Bonn-Shutter UG.

  11. Integrated Three-Port DC-DC Converter for Photovoltaic (PV) Battery Stand-alone Systems

    DEFF Research Database (Denmark)

    Ouyang, Ziwei; Andersen, Michael A. E.

    2016-01-01

    Several power sources such as PV solar arrays and battery are often used to manage the power flow for a photovoltaic (PV) based stand-alone power system due to the fluctuation nature of solar energy resource, and deliver a continuous power to the users in an appropriate form. Traditionally, three...... of solar energy. Moreover, a novel transformer configuration enables variable turns ratio controlled by the phase between the two current excitations subjected to the primary windings, allowing a wider input/output range. 1 kW experimental prototype has been built to demonstrate a wellmanaged power flow...... different single-input single-output (SISO) dc/dc converters would have been used. To reduce the cost and improve the power density of the system, an integrated three-port isolated dc/dc converter is proposed in this paper. It can realize all functions of the energy delivery due to the fluctuation nature...

  12. Multi-port power router and its impact on resilient power grid systems

    Science.gov (United States)

    Kado, Yuichi; Iwatsuki, Katsumi; Wada, Keiji

    2016-02-01

    We propose a Y-configuration power router as a unit cell to easily construct a power delivery system that can meet many types of user requirements. The Y-configuration power router controls the direction and magnitude of power flow among three ports regardless of DC and AC. We constructed a prototype three-way isolated DC/DC converter that is the core unit of the Y-configuration power router and tested the power flow control operation. Experimental results revealed that our methodology based on the governing equation was appropriate for the power flow control of the three-way DC/DC converter. In addition, the hexagonal distribution network composed of the power routers has the ability to easily interchange electric power between autonomous microgrid cells. We also explored the requirements for communication between energy routers to achieve dynamic adjustments of energy flow in a coordinated manner and its impact on resilient power grid systems.

  13. Extravehicular Activity (EVA) Power, Avionics, and Software (PAS) 101

    Science.gov (United States)

    Irimies, David

    2011-01-01

    EVA systems consist of a spacesuit or garment, a PLSS, a PAS system, and spacesuit interface hardware. The PAS system is responsible for providing power for the suit, communication of several types of data between the suit and other mission assets, avionics hardware to perform numerous data display and processing functions, and information systems that provide crewmembers data to perform their tasks with more autonomy and efficiency. Irimies discussed how technology development efforts have advanced the state-of-the-art in these areas and shared technology development challenges.

  14. Use of Implantable Venous Port Systems in the Treatment of Children with Orphan Diseases (Mucopolysaccharidosis and Pompe Disease: Case Series

    Directory of Open Access Journals (Sweden)

    M. Yu. Rykov

    2015-01-01

    Full Text Available Many orphan diseases in children require life-long and regular intravenous enzyme replacement therapy. The article describes the first Russian practice of implanting venous port systems in 12 patients with type I and II mucopolysaccharidosis and Pompe disease (6 months to 17 years old to create long-term venous access. Currently, implantable venous port systems are used in 9 (75% of 12 patients. 4 cases of thrombosis are observed in 3 patients. All of them have been successfully treated. 1 patient had a rotation of the port camera with a membrane facing downwards due to violation of an implantation technique. The camera was adjusted during the second operation.

  15. USAGE OF STANDARD PERSONAL COMPUTER PORTS FOR DESIGNING OF THE DOUBLE REDUNDANT FAULT-TOLERANT COMPUTER CONTROL SYSTEMS

    Directory of Open Access Journals (Sweden)

    Rafig SAMEDOV

    2005-01-01

    Full Text Available In this study, for designing of the fault-tolerant control systems by using standard personal computers, the ports have been investigated, different structure versions have been designed and the method for choosing of an optimal structure has been suggested. In this scope, first of all, the ÇİFTYAK system has been defined and its work principle has been determined. Then, data transmission ports of the standard personal computers have been classified and analyzed. After that, the structure versions have been designed and evaluated according to the used data transmission methods, the numbers of ports and the criterions of reliability, performance, truth, control and cost. Finally, the method for choosing of the most optimal structure version has been suggested.

  16. High Efficiency Non-isolated Three Port DC-DC Converter for PV-Battery Systems

    DEFF Research Database (Denmark)

    Tomas Manez, Kevin; Anthon, Alexander; Zhang, Zhe

    2016-01-01

    This paper presents a nonisolated Three Port Converter (TPC) with a unidirectional port for photovoltaic (PV) panels and a bidirectional port for energy storage. With the proposed topology single power conversion is performed between each port, so high efficiencies are obtained. A theoretical...... analysis is carried out to analyze all operating modes and design considerations with the main equations are given. A 4kW laboratory prototype is developed and tested under all operating conditions. Results obtained feature on efficiencies higher than 97% for all operating modes and all power levels from...

  17. Numerical simulation of draining and drying procedure for the ITER Generic Equatorial Port Plug cooling system

    Energy Technology Data Exchange (ETDEWEB)

    Tanchuk, Victor, E-mail: Victor.Tanchuk@sintez.niiefa.spb.su [JSC “D.V. Efremov Institute of Electrophysical Apparatus”, 196641 St. Petersburg (Russian Federation); Grigoriev, Sergey; Lyublin, Boris [JSC “D.V. Efremov Institute of Electrophysical Apparatus”, 196641 St. Petersburg (Russian Federation); Maquet, Philippe [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Senik, Konstantin [JSC “D.V. Efremov Institute of Electrophysical Apparatus”, 196641 St. Petersburg (Russian Federation); Pak, Sunil [National Fusion Research Institute, Daejeon (Korea, Republic of); Udintsev, Victor [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France)

    2016-11-01

    Highlights: • The cooling system of the ITER Generic Equatorial Port Plug (GEPP) is of a complicated combination of horizontal and vertical channels. • The calculation model for the entire GEPP cooling circuit comprising 12 sub-circuits and built up of 2421 finite-volume elements has been developed. • Transient analysis of this model simulating the draining procedure by the KORSAR/B1 code has been performed. • Water in amount of 263 g of initial 531 kg in the GEPP remains in the dead-ends of the DSM and DFW channels in 150 s of draining procedure. • Almost 3 h are required to boil off 263 g of water trapped in the dead-ends. - Abstract: For effective vacuum leak testing all cooling circuits serving the ITER vessel and in-vessel components shall be drained and dried so that after this procedure taking less than 100 h the purge gas passing through a component has water content less than 100 ppm. This process is four-stage, with the first stage using a short blast of compressed nitrogen to blow most of water in the coolant channels out of the circuit. This process is hindered by volumes which trap water due to gravity. To remove the trapped water, it is necessary, first, to heat up the structure by hot and compressed nitrogen, and then water is evaporated by depressurized nitrogen. The cooling system of the ITER Diagnostic Equatorial Port Plugs is of a complicated hydraulic configuration. The system branching might make difficult removal of water from the piping in the scheduled draining mode. The authors have proposed the KORSAR computation code to simulate draining of the GEPP cooling circuit. The numerical simulation performed has made it possible to describe the process dynamics during draining of the entire GEPP cooling circuit and to define the process time, amount and location of residual water and evolution of two-phase flow regime.

  18. Percutaneous implantation of intra-arterial port system for regional drug infusion: results and complications in 110 cases

    Energy Technology Data Exchange (ETDEWEB)

    Won, Je Hwan; Lee, Jong Hyuk [College of Medicine, Ajou University, Seoul (Korea, Republic of); Ko, Kyung Hee; Won, Jong Yoon; Park, Sung Il; Lee, Do Yun [College of Medicine, Yonsei University, Seoul (Korea, Republic of); Kang, Byung Chul [Mokdong Hospital, College of Medicine, Ehwa Womans University, Seoul (Korea, Republic of)

    2000-10-01

    To investigate the feasibility and complications of a percutaneously implantable port system for regional drug infusion. For intra-arterial drug infusion, a 5.8 or 5-F pediatric venous port system was implanted in 110 patients with hepatocellular carcinoma (n=79), liver metastasis (n=16), gallbladder cancer (n=4), stomach cancer (n=3), pancreatic cancer (n=3), Burger's diseases mellitus (n=2), or lymphoma (n=1). All intra-arterial port implantations were performed percutaneously in an angiographic ward through the common femoral artery (n=98), left subclavian artery (n=10), or left superficial femoral artery (n=2). Complications were evaluated during the follow-up period, which ranged from 21 to 530 (mean, 163) days. The technical success rate for percutaneous implantation of the system was 97.3% (107 of 110 patients). The tips of the port catheter were located in the common hepatic artery (n=34), proper hepatic artery (n=49), right hepatic artery quick resulthepatic artery (n=1), descending aorta at T9 level (n=10), left popliteal artery (n=2), right external iliac artery (n=1), left external iliac artery (n=1), or left deep femoral artery (n=1). Complications were encountered in 24 patients (22.4%), namely chamber site infection (n=7), catheter dislodgement (n=7), catheter occlusion (n=3), migration of coil (n=2), disconnection between chamber and catheter (n=1), kinking of catheter (n=1), arterial occlusion (n=1), necrosis of overlying skin (n=1), and leakage around port chamber (n=1). Outcomes of complications included removal of port systems or cessation of therapy in 12 cases (11.2%), correction of catheter location using a guide wire in five (4.7%), thrombolysis with urokinase in three (2.8%), and straightening using a snare in one (0.9%). In three patients, the port system was used without reintervention. Percutaneous implantation of an intra-arterial port system showed a high technical success rate and a low rate of serious complications. The method

  19. Simulation Modelling and Heuristics Optimization of Material Flow of the Port Cargo System

    Directory of Open Access Journals (Sweden)

    Joško Dvornik

    2006-03-01

    Full Text Available Simulation Modelling, together with System Dynamics andintensive use of modem digital computer, which means massiveapplication, today very inexpensive and at the same timevery powerful personal computers (PCs, is one of the mostsuitable and effective scientific ways for investigation of the dynamicsbehaviour of non-linear and complex: natural, technicaland organization systems.The methodology of System Dynamics ( Prof dr. J. F arrester- MJT, e. g. a relatively new scientific discipline, in the fonnereducational and designer practice showed its efficiency in practiceas very suitable means for solving the problems of management,behaviour, sensibility, flexibility and sensibility of behaviourdynamics of different systems and processes.The system-dynamics computer simulation methodologywas used from 1991 to 2003 for modelling of dynamics behaviourof a large number of non-linear ship electrical, thenno-dynamical,hydraulic, mechanical and pneumatic systems. Thismethodology is used by students as the material for graduatetheses, and for realization and publishing the results of scientificresearch work by the professors at High Maritime Schooland Maritime Faculty Split.The aim of this paper is to show the efficiency of the applicationof the System Dynamics Simulation Modelling in investigationof behaviours dynamics, one of the Port-Transhipmentsystems presented with mental-verbal, structural and mathematical-computing modules, and it will simulate transhipmentport working processes.

  20. Outcome analysis in 3,160 implantations of radiologically guided placements of totally implantable central venous port systems

    Energy Technology Data Exchange (ETDEWEB)

    Teichgraeber, Ulf K.M. [Charite University Hospital, Department of Radiology, Berlin (Germany); Charite Universitaetsmedizin Berlin, Institut fuer Diagnostische und Interventionelle Radiologie, Berlin (Germany); Kausche, Stephan; Nagel, Sebastian N.; Gebauer, Bernhard [Charite University Hospital, Department of Radiology, Berlin (Germany)

    2011-06-15

    In this retrospective study the success and complication rates after radiologically guided port catheter implantation were evaluated. Between 2000 and 2008, 3,160 port catheter systems were implanted in our interventional suite. All interventions were imaging guided. The puncture of the preferably right internal jugular vein (IJV) was ultrasound-assisted and the catheter tip position was controlled with fluoroscopy. Catheter indwelling time and rates of periprocedural, early and late complications were evaluated. 922,599 catheter days (mean, 292 days; range, 0-2,704 days) were documented. The implantation was successful in 3,153 (99.8%) cases. A total of 374 (11.8%; 0.41/1,000 catheter days) adverse events were recorded. Of these, 42 (1.33%) were periprocedural complications. 86 (3.3%; 0.09/1,000 catheter days) early and 246 (9.4%; 0.27/1,000 catheter days) late onset complications occurred after port implantation. The most common complications were blood stream infection (n = 134; 5.1%; 0.15/1,000 catheter days), catheter-induced venous thrombosis (n = 97; 3.7%; 0.11/1,000 catheter days) and catheter migration (n = 34; 1.3%; 0.04/1,000 catheter days). A total of 193 (6.1%) port explantations were required. Ultrasound guided port implantation via the IJV results in low periprocedural complication rates. (orig.)

  1. Patient satisfaction with PAs in the Netherlands.

    Science.gov (United States)

    Meijer, Koos; Kuilman, Luppo

    2017-05-01

    Physician assistants (PAs) were introduced in the Netherlands in 2002 and are now widely deployed. However, little is known about patient satisfaction with Dutch PAs. A comparative study of patient satisfaction was undertaken in the primary care setting. Patients seen by general practitioners (GPs) and PAs were surveyed using the Consumer Quality Index, a European quality survey instrument. Quality of performance indicators included patient satisfaction, effectiveness of treatment, and safety of treatment. The results found that few differences emerged, and Dutch patients appear to be as satisfied with the care received by PAs as with GPs.

  2. A novel optimal coordinated control strategy for the updated robot system for single port surgery.

    Science.gov (United States)

    Bai, Weibang; Cao, Qixin; Leng, Chuntao; Cao, Yang; Fujie, Masakatsu G; Pan, Tiewen

    2017-09-01

    Research into robotic systems for single port surgery (SPS) has become widespread around the world in recent years. A new robot arm system for SPS was developed, but its positioning platform and other hardware components were not efficient. Special features of the developed surgical robot system make good teleoperation with safety and efficiency difficult. A robot arm is combined and used as new positioning platform, and the remote center motion is realized by a new method using active motion control. A new mapping strategy based on kinematics computation and a novel optimal coordinated control strategy based on real-time approaching to a defined anthropopathic criterion configuration that is referred to the customary ease state of human arms and especially the configuration of boxers' habitual preparation posture are developed. The hardware components, control architecture, control system, and mapping strategy of the robotic system has been updated. A novel optimal coordinated control strategy is proposed and tested. The new robot system can be more dexterous, intelligent, convenient and safer for preoperative positioning and intraoperative adjustment. The mapping strategy can achieve good following and representation for the slave manipulator arms. And the proposed novel control strategy can enable them to complete tasks with higher maneuverability, lower possibility of self-interference and singularity free while teleoperating. Copyright © 2017 John Wiley & Sons, Ltd.

  3. Engineering requirements due to the ESP/ESPN regulation apply at the port plug for ITER diagnostic system

    Energy Technology Data Exchange (ETDEWEB)

    Giacomin, T., E-mail: Thibaud.Giacomin@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Delhom, D.; Drevon, J.-M. [Bertin Technologies, Aix en Provence (France); Guirao, J.; Iglesias, S. [NATEC Ingenieros (Spain); Jourdan, T. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Loesser, D. [Princeton Plasma Physics Laboratory (United States); Maquet, P. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Ordieres, J. [NATEC Ingenieros (Spain); Pak, S. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Proust, M. [CEA Cadarache, St. Paul-lez-Durance (France); Smith, M. [Princeton Plasma Physics Laboratory (United States); Udintsev, V.S. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Vacas, C. [NATEC Ingenieros (Spain); Walsh, M.J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Zhai, Y. [Princeton Plasma Physics Laboratory (United States)

    2015-10-15

    Highlights: • The ESP/ESPN regulation is applied to all equatorial and upper port-based diagnostic systems. • The EPP and UPP structure provides a flexible platform for a variety of diagnostics. • The EPP and UPP structure provide a support the diagnostic shielding module. - Abstract: Due to this position close to the plasma, the port plug structure and the diagnostic first wall (DFW) contain water to allow cooling during operation and for heating during bake-out. To remove the heat coming from the plasma due to radiation and neutrons, the pressure inside these structures should be up to 44 bars. On the other hand, the dominant load expected to drive the design of these structures is of electromagnetic origin during the plasma disruption. Description of the loads acting on DFWs and generic port plug structures and the significance of the load due to the water pressure, with implications on the design and inspection, are discussed in this paper.

  4. Tritium and heat management in ITER Test Blanket Systems port cell for maintenance operations

    Energy Technology Data Exchange (ETDEWEB)

    Giancarli, L.M., E-mail: luciano.giancarli@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Cortes, P.; Iseli, M.; Lepetit, L.; Levesy, B. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Livingston, D. [Frazer-Nash Consultancy Ltd., Stonebridge House, Dorking Business Park, Dorking, Surrey RH4 1HJ (United Kingdom); Nevière, J.C. [Comex-Nucleaire, 13115 Saint Paul Lez Durance (France); Pascal, R. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Ricapito, I. [Fusion for Energy, Josep Pla, 2, Torres Diagonal Litoral B3, Barcelona E-08019 (Spain); Shu, W. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Wyse, S. [Frazer-Nash Consultancy Ltd., Stonebridge House, Dorking Business Park, Dorking, Surrey RH4 1HJ (United Kingdom)

    2014-10-15

    Highlights: •The ITER TBM Program is one of the ITER missions. •We model a TBM port cell with CFD to optimize the design choices. •The heat and tritium releases management in TBM port cells has been optimized. •It is possible to reduce the T-concentration below one DAC in TBM port cells. •The TBM port cells can have human access within 12 h after shutdown. -- Abstract: Three ITER equatorial port cells are dedicated to the assessment of six different designs of breeding blankets, known as Test Blanket Modules (TBMs). Several high temperature components and pipework will be present in each TBM port cell and will release a significant quantity of heat that has to be extracted in order to avoid the ambient air and concrete wall temperatures to exceed allowable limits. Moreover, from these components and pipes, a fraction of the contained tritium permeates and/or leaks into the port cell. This paper describes the optimization of the heat extraction management during operation, and the tritium concentration control required for entry into the port cell to proceed with the required maintenance operations after the plasma shutdown.

  5. Development of a virtual wave buoy system for the Port of Cape Town, South Africa

    CSIR Research Space (South Africa)

    Rossouw, Marius

    2005-07-01

    Full Text Available The Port of Cape Town is located in Table Bay on the south-west coast of South Africa. Since the port experiences advese weather conditions, especially during the winter period, the monitoring of marine weather and wave conditions forms an integral...

  6. Final design of the generic upper port plug structure for ITER diagnostic systems

    NARCIS (Netherlands)

    Pak, S.; Feder, R.; Giacomin, T.; Guirao, J.; Iglesias, S.; Josseaume, F.; Kalish, M.; Loesser, D.; Maquet, P.; Ronden, D.; Ordieres, J.; Panizo, M.; Pitcher, S.; M. Portalès,; Proust, M.; Serikov, A.; Suarez, A.; Tanchuk, V.; Udintsev, V.; Vacas, C.; Walsh, M.; Zhai, Y.

    2016-01-01

    The generic upper port plug (GUPP) structure in ITER is a 6 m long metal box which deploys diagnostic components into the vacuum vessel. This structure is commonly used for all the diagnostic upper ports. The final design of the GUPP structure, which has successfully passed the final design review

  7. Interconnection and Damping Assignment Passivity-Based Control for Port-Hamiltonian mechanical systems with only position measurements

    NARCIS (Netherlands)

    Dirksz, D. A.; Scherpen, J. M. A.; Ortega, R.

    2008-01-01

    A dynamic extension for position feedback of port-Hamiltonian mechanical systems is studied. First we look at the consequences for the matching equations when applying Interconnection and Damping Assignment Passivity-Based Control (IDA-PBC). Then we look at the possibilities of asymptotically

  8. Design of the ITER upper port electron cyclotron heating and current drive system based on remote steering

    NARCIS (Netherlands)

    M. F. Graswinckel,; van den Berg, M. A.; Bongers, W. A.; Donne, A. J. H.; Goede, A. P. H.; Cardozo, N. L.; Ronden, D. M. S.; Verhoeven, A. G. A.

    2008-01-01

    A design is presented for the electron cyclotron (EC) heating and current drive system of the ITER upper port launchers based on the remote steering (RS) concept. In this concept the millimeter-wave beam is steered by a mirror that is located at the back end of the launcher waveguide. The RS concept

  9. Low cost, robust and real time system for detecting and tracking moving objects to automate cargo handling in port terminals

    NARCIS (Netherlands)

    Vaquero, V.; Repiso, E.; Sanfeliu, A.; Vissers, J.; Kwakkernaat, M.

    2016-01-01

    The presented paper addresses the problem of detecting and tracking moving objects for autonomous cargo handling in port terminals using a perception system which input data is a single layer laser scanner. A computationally low cost and robust Detection and Tracking Moving Objects (DATMO) algorithm

  10. The partial contraction approach for convergence analysis in the tracking control of mechanical portHamiltonian systems

    NARCIS (Netherlands)

    Reyes Báez, Rodolfo; van der Schaft, Abraham; Jayawardhana, Bayu

    2017-01-01

    The problem of set-point regulation (stabilization) of mechanical port-Hamiltonian (pH) systems has been widely studied in the literature by means of energy-based methods. However, for motion control problems, where the reference signal is time-varying, it is not straightforward to design control

  11. A dual relation between port-Hamiltonian systems and the Brayton–Moser equations for nonlinear switched RLC circuits

    NARCIS (Netherlands)

    Jeltsema, Dimitri; Scherpen, Jacquelien M.A.

    2003-01-01

    In the last decades, several researchers have concentrated on the dynamic modeling of nonlinear electrical circuits from an energy-based perspective. A recent perspective is based on the concept of port-Hamiltonian (PH) systems. In this paper, we discuss the relations between the classical

  12. Preparation of dry ports for a competitive environment in the container seaport system: A process benchmarking approach

    Directory of Open Access Journals (Sweden)

    J. Jeevan

    2017-06-01

    Full Text Available The significant exodus of containers inland due to the container revolution has increased the salience of inland terminals for efficient freight distribution. Further, the migration of containers gradually inland has forced seaports to depend on these inland terminals to determine their competitiveness and offer a mechanism for competitive freight price to the consumer. The performance of dry ports need to be improved along with the dynamic nature of maritime business, to efficiently fulfil the demand all the key players in the container seaport system, provide economies of scale and scope to their respective clients and enhances the importance of inland networks to improve and consistently elongate the competitiveness of container seaports. Predicated to these importance, this paper aims to enhance dry port performance by adapting a process benchmarking strategy among the Malaysian dry ports. Prior to the adaptation of the process benchmarking approach, a grounded theory had been conducted as a method of analysis among the key players of the Malaysian container seaport system in order to provide essential inputs for the benchmarking. Through this paper, the outcome shows all four Malaysian dry ports need to improve their transportation infrastructure and operation facilities, container planning strategy, competition, location and externalities in order to assist all the key players in the container seaport system efficiently and effectively.

  13. Vectorization, parallelization and porting of nuclear codes on the VPP500 system (vectorization). Progress report fiscal 1996

    Energy Technology Data Exchange (ETDEWEB)

    Nemoto, Toshiyuki; Kawai, Wataru [Fujitsu Ltd., Tokyo (Japan); Kawasaki, Nobuo [and others

    1997-12-01

    Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. These results are reported in 3 parts, i.e., the vectorization part, the parallelization part and the porting part. In this report, we describe the vectorization. In this vectorization part, the vectorization of two and three dimensional discrete ordinates simulation code DORT-TORT, gas dynamics analysis code FLOWGR and relativistic Boltzmann-Uehling-Uhlenbeck simulation code RBUU are described. In the parallelization part, the parallelization of 2-Dimensional relativistic electromagnetic particle code EM2D, Cylindrical Direct Numerical Simulation code CYLDNS and molecular dynamics code for simulating radiation damages in diamond crystals DGR are described. And then, in the porting part, the porting of reactor safety analysis code RELAP5/MOD3.2 and RELAP5/MOD3.2.1.2, nuclear data processing system NJOY and 2-D multigroup discrete ordinate transport code TWOTRAN-II are described. And also, a survey for the porting of command-driven interactive data analysis plotting program IPLOT are described. (author)

  14. Vectorization, parallelization and porting of nuclear codes on the VPP500 system (parallelization). Progress report fiscal 1996

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Hideo; Kawai, Wataru; Nemoto, Toshiyuki [Fujitsu Ltd., Tokyo (Japan)] [and others

    1997-12-01

    Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. These results are reported in 3 parts, i.e., the vectorization part, the parallelization part and the porting part. In this report, we describe the parallelization. In this parallelization part, the parallelization of 2-Dimensional relativistic electromagnetic particle code EM2D, Cylindrical Direct Numerical Simulation code CYLDNS and molecular dynamics code for simulating radiation damages in diamond crystals DGR are described. In the vectorization part, the vectorization of two and three dimensional discrete ordinates simulation code DORT-TORT, gas dynamics analysis code FLOWGR and relativistic Boltzmann-Uehling-Uhlenbeck simulation code RBUU are described. And then, in the porting part, the porting of reactor safety analysis code RELAP5/MOD3.2 and RELAP5/MOD3.2.1.2, nuclear data processing system NJOY and 2-D multigroup discrete ordinate transport code TWOTRAN-II are described. And also, a survey for the porting of command-driven interactive data analysis plotting program IPLOT are described. (author)

  15. 78 FR 7334 - Port Authority Access to Facility Vulnerability Assessments and the Integration of Security Systems

    Science.gov (United States)

    2013-02-01

    ... parties, as well as ] current industry practices on facility interactions with port authorities, State and... and execute training, and on-going maintenance costs. Cost estimates can be provided as ranges. 2. We...

  16. The effects of low dose chemotherapy for advanced hepatocellular carcinoma through percutaneously implanted intra-arterial port system

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyun Seok; Won, Je Hwan; Yoo, Byung Moo; Kim, Young Soo; Cho, Sung Won [Ajou Univ. College of Medicine, Suwon (Korea, Republic of); Park, Dong Won [Suwon Medical Center, Suwon (Korea, Republic of)

    2001-07-01

    To investigate the effects of low-dose FP (5-Fluorouracil[5FU]+Cispatin[CDDP]) therapy through a percutaneously implanted intra-arterial port system in patients with advanced hepatocellular carcinoma (HCC). Twenty-five patients with advanced HCCs and portal vein thrombosis, or large HCCs which were unresectable or for which transarterial chemoembolization was thought to be ineffective, underwent intra-arterial port implantation. The mean maxinal diameter of these tumors was 13.7 (range, 5-21.5) cm, and they were located at the right lobe (n=18), the left lobe(n=3), or throughout the liver (n=4). Tumor thrombosis was detected in the main (n=14), right (n=3) and left portal vein(n=1), the right portal vein and inferior vena cava(n=2), and the inferior vena cava(n=1). The four others patients had no portal vein thrombosis. All intra-arterial port implantations were performed percutaneously in the angiographic ward through the right or left common femoral artery. The port chamber was implanted in the inguinal area and fixed using histoacryl. For intra-arterial chemotherapy, 5-FU (250 mg/day) and CDDP (10 mg/day) were used for five days every four weeks. In order to observe changes in tumor size, follow-up CT scanning was performed every two months. Implantation of the port system was successful in all cases, and patients underwent between one and eleven (mena, 3.9) sessions of chemotherapy. Port-and catheter-related complications, namely dislodgement of the catheter(n=2), wound infection(n=2), migration of the coil(n=1) and catheter occlusion(n=1) occurred in six patients (24%), and chemotherapy-related complications, namely liver failure(n=3) and gastric ulcer bleeding(n=1), in four (16%). A complete response, i. e. the disappearance of tumor thrombosis of the portal vein, was achieved in one patient (4%), a partial response in three (12%), and a minor response in four (16%); the overall response rate was 32% and the mean survival period was 7.6 months. Low-dose FP

  17. Application of ICT in systems management of the port SME sector

    OpenAIRE

    Jairo Augusto Cortes Méndez; Jaime Alberto Páez Páez; Jairo Oswaldo Lozano

    2016-01-01

    The project as a result of the research entitled "Impact of ICT in the organizational structure of SMEs in the port sector using virtual environments" under CONADI convening of the Cooperative University of Colombia, measures and verifies how Information Technology and Communication, ICT, have influenced the organizational structure of SMEs (Small and medium enterprises) in the port sector, analyzing each of the perspectives and organizational components and how these can be adapted using ICT...

  18. Flow confirmation study for central venous port in oncologic outpatient undergoing chemotherapy: Evaluation of suspected system-related mechanical complications

    Energy Technology Data Exchange (ETDEWEB)

    Sofue, Keitaro, E-mail: ksofue@ncc.go.jp [Divisions of Diagnostic Radiology, National Cancer Center Hospital (Japan); Department of Radiology, Kobe University, Graduate School of Medicine (Japan); Arai, Yasuaki; Takeuchi, Yoshito [Divisions of Diagnostic Radiology, National Cancer Center Hospital (Japan); Sugimura, Kazuro [Department of Radiology, Kobe University, Graduate School of Medicine (Japan)

    2013-11-01

    Purpose: To evaluate the efficacy and outcome of a flow confirmation study (FCS) in oncologic outpatients undergoing chemotherapy suspected of a central venous port (CVP) system-related mechanical complication. Materials and methods: A total of 66 patients (27 men, 39 women; mean age, 60 years) received FCS for the following reasons: prolonged infusion time during chemotherapy (n = 32), inability to inject saline fluid (n = 15), lateral neck and/or back pain (n = 6), subcutaneous extravasation of anticancer drug (n = 5), arm swelling (n = 4), and inability to puncture the port (n = 4). FCS consisted of examining the position of CVP, potential secondary shifts or fractures, and integrity of the system using contrast material through the port. Results: Of the 66 patients, 43 had an abnormal finding uncovered by FCS. The most frequent abnormal findings was catheter kinking (n = 22). Explantation and reimplantation of the CVP system was required in 21 of the 66 patients. Remaining 45 patients were able continue using the CVP system after the FCS without any system malfunction. Conclusion: FCS was effective for evaluating CVP system-related mechanical complications and was useful for deciding whether CVP system explantation and reimplantation was required.

  19. Three-dimensional transient numerical simulation for intake process in the engine intake port-valve-cylinder system.

    Science.gov (United States)

    Luo, Ma-Ji; Chen, Guo-Hua; Ma, Yuan-Hao

    2003-01-01

    This paper presents a KIVA-3 code based numerical model for three-dimensional transient intake flow in the intake port-valve-cylinder system of internal combustion engine using body-fitted technique, which can be used in numerical study on internal combustion engine with vertical and inclined valves, and has higher calculation precision. A numerical simulation (on the intake process of a two-valve engine with a semi-sphere combustion chamber and a radial intake port) is provided for analysis of the velocity field and pressure field of different plane at different crank angles. The results revealed the formation of the tumble motion, the evolution of flow field parameters and the variation of tumble ratios as important information for the design of engine intake system.

  20. Green Port / Eco Port Project - Applications and Procedures in Turkey

    Science.gov (United States)

    Akgul, Burak

    2017-12-01

    As being the heartlands of international trade, sea ports are the junction points of land and sea routes. The growth of global trade has led to the development of number and capacity as well as the service quality of ports. The policies and procedures applied during construction, operation and development of ports under development with environmental considerations scope has evolved in accordance with the needs of global trends. Although maritime transportation provides the most ecofriendly transportation method, the reduction of potential environmental threats and continuous improvement of ports and their vicinity is paramount from environmental concerns with regards to the international environmental standards. In the context of the study, national and international legal regulations governing the control of the environmental impacts of the activity groups causing pollution in Turkey based sea ports were viewed. In addition, the models applied during the measurement and documentation of environmental impacts were investigated. The most important aspects in terms of the effectiveness of the environmental management models are legal regulations. However, the standards applied at the ports without any legal obligation, such as EcoPorts applications, ISO 14001 standard, and the EMAS (Eco-Management and Audit Scheme) were sought in the scope of the study. The boundaries of the study were determined as the EU based Environmental Management Systems and the Green Port/Eco Port Project which is being administered by the Turkish Ministry of Transport, Maritime and Communication. “Marport”, which is Turkey’s first certified Green Port / Eco Port is designated as the experimental study site. In addition, the provisions in the ports of ESPO member countries are approached in order to compare the effectiveness and applicability of Green Port / Eco Port Project.

  1. Final design of the generic upper port plug structure for ITER diagnostic systems

    Energy Technology Data Exchange (ETDEWEB)

    Pak, Sunil, E-mail: paksunil@nfri.re.kr [National Fusion Research Institute, Daejeon (Korea, Republic of); Feder, Russell [Princeton Plasma Physics Laboratory, Princeton, NJ (United States); Giacomin, Thibaud; Guirao, Julio; Iglesias, Silvia; Josseaume, Fabien [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Kalish, Michael; Loesser, Douglas [Princeton Plasma Physics Laboratory, Princeton, NJ (United States); Maquet, Philippe [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Ordieres, Javier; Panizo, Marcos [NATEC, Ingenieros, Gijón (Spain); Pitcher, Spencer; Portalès, Mickael [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Proust, Maxime [CEA, Cadarache, St. Paul-lez-Durance (France); Ronden, Dennis [FOM Institute DIFFER, Nieuwegein (Netherlands); Serikov, Arkady [Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen (Germany); Suarez, Alejandro [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Tanchuk, Victor [NIIEFA, St.-Petersburg (Russian Federation); Udintsev, Victor; Vacas, Christian [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); and others

    2016-01-15

    The generic upper port plug (GUPP) structure in ITER is a 6 m long metal box which deploys diagnostic components into the vacuum vessel. This structure is commonly used for all the diagnostic upper ports. The final design of the GUPP structure, which has successfully passed the final design review in 2013, is described here. The diagnostic port plug is cantilevered to the vacuum vessel with a heavy payload at the front, so called the diagnostic first wall (DFW) and the diagnostic shield module (DSM). Most of electromagnetic (EM) load (∼80%) occurs in DFW/DSM. Therefore, the mounting design to transfer the EM load from DFW/DSM to the GUPP structure is challenging, which should also comply with thermal expansion and tolerance for assembly and manufacturing. Another key design parameter to be considered is the gap between the port plug and the vacuum vessel port. The gap should be large enough to accommodate the remote handling of the heavy port plug (max. 25 t), the structural deflection due to external loads and machine assembly tolerance. At the same time, the gap should be minimized to stop the neutron streaming according to the ALARA (as low as reasonably achievable) principle. With these design constraints, the GUPP structure should also provide space for diagnostic integration as much as possible. This requirement has led to the single wall structure having the gun-drilled water channels inside the structure. Furthermore, intensive efforts have been made on the manufacturing study including material selection, manufacturing codes and French regulation related to nuclear equipment and safety. All these main design and manufacturing aspects are discussed in this paper, including requirements, interfaces, loads and structural assessment and maintenance.

  2. Performance Analysis of a Six-Port Receiver in a WCDMA Communication System including a Multipath Fading Channel

    Directory of Open Access Journals (Sweden)

    A. O. Olopade

    2014-01-01

    Full Text Available Third generation communication systems require receivers with wide bandwidth of operation to support high transmission rates and are also reconfigurable to support various communication standards with different frequency bands. An ideal software defined radio (SDR will be the absolute answer to this requirement but it is not achievable with the current level of technology. This paper proposes the use of a six-port receiver (SPR front-end (FE in a WCDMA communication system. A WCDMA end-to-end physical layer MATLAB demo which includes a multipath channel distortion block is used to determine the viability of the six-port based receiver. The WCDMA signal after passing through a multipath channel is received using a constructed SPR FE. The baseband signal is then calibrated and corrected in MATLAB. The six-port receiver performance is measured in terms of bit error rate (BER. The signal-to-noise ratio (SNR of the transmitted IQ data is varied and the BER profile of the communication system is plotted. The effect of the multipath fading on the receiver performance and the accuracy of the calibration algorithm are obtained by comparing two different measured BER curves for different calibration techniques to the simulated BER curve of an ideal receiver.

  3. IN VITRO FLOW ANALYSIS OF NOVEL DOUBLE-CUTTING, OPEN-PORT, ULTRAHIGH-SPEED VITRECTOMY SYSTEMS.

    Science.gov (United States)

    Zehetner, Claus; Moelgg, Marion; Bechrakis, Emmanouil; Linhart, Caroline; Bechrakis, Nikolaos E

    2017-10-09

    To analyze the performance and flow characteristics of novel double-cutting, open-port, 23-, 25-, and 27-gauge ultrahigh-speed vitrectomy systems. In vitro fluidic measurements were performed to assess the volumetric aspiration profiles of several vitrectomy systems in basic salt solution and egg white. Double-cutting open-port vitrectomy probes delivered stable aspiration flow rates that were less prone to flow variation affected by the cutting speed. Increase in cutting frequency to the maximum level resulted in flow reduction of less than 10% (0.0%-9.5%). Commercially available 23-, 25-, and 27-G double-cutting probes exhibited higher egg-white and basic salt solution flow rates at all evaluated cut rates, with aspirational efficiencies being 1.1 to 2.9 times the flow rates of standard single-blade vitrectomy probes of the same caliber at the maximum preset vacuum. The highest relative differences were observed at faster cut rates. The newly introduced double-cutting open-port vitrectomy probes delivered stable aspiration flow rates that were less prone to flow variation affected by the cutting speed. The fluidic principle of constant flow even at the highest cut rates and low vacuum levels might impact surgical strategies, especially when performing manipulations close to the retina.

  4. Ultrasound guided implantation of chest port systems via the lateral subclavian vein; Die sonographisch gezielte Implantation von Portkathetersystemen ueber die laterale Vena subclavia

    Energy Technology Data Exchange (ETDEWEB)

    Zaehringer, M.; Hilgers, J.; Krueger, K.; Strohe, D.; Bangard, C.; Neumann, L.; Lackner, K. [Inst. fuer Radiologische Diagnostik, Univ. zu Koeln (Germany); Warm, M. [Gynaekologie, Univ. zu Koeln (Germany); Reiser, M. [Medizinische Klinik I, Univ. zu Koeln (Germany); Toex, U. [Medizinische Klinik IV, Univ. zu Koeln (Germany)

    2006-03-15

    Purpose: Retrospective analysis of the success and complication rates of chest port implantation via the lateral subclavian vein. Materials and methods: Between January 2003 and June 2004, the lateral subclavian vein in 271 patients (186 women, 85 men, mean age 53.2 years) was punctured guided by ultrasound. This access was used to insert a port system, and the catheter tip was placed at the cavoatrial junction. The port reservoir was implanted in a subcutaneous infraclavicular pocket and fixed to the fascia of the pectoralis muscle. Indications for port implantation were chemotherapy (n=239), total parenteral nutrition (n=2) and intravenous medication (n=30). The patient follow-up was mainly performed either by the oncology division of the department of gynecology or by the department of internal medicine. Results: A chest port catheter system was successfully implanted in all patients. The catheter remained in place for a mean duration of 269.4 days (SD 192.3 days). No complications occurred during implantation. In the post-interventional period, 6 catheter dysfunctions were found (thrombotic 0.09 per 1000 catheter days; mechanic 0.05 per 1000 catheter days). While one local infection occurred in the early post-interventional period, 3 local and 15 systemic infections were independent of the port catheter placement (0.39 per 1000 catheter days). The rate of port catheter explantations due to dysfunction or infection was 0.07 per 1000 catheter days. Conclusion: Ultrasound-guided puncture of the lateral subclavian vein is a safe procedure for the insertion of central venous port catheter systems and had a very low complication rate in our study. For further evaluation of our port placement technique, prospective studies compared to placement through the internal jugular vein are necessary. (orig.)

  5. 77 FR 44472 - Safety Zone; Port Valdez, Alaska Maritime Highway System Ferry Terminal

    Science.gov (United States)

    2012-07-30

    ... . If you have questions on viewing the docket, call Renee V. Wright, Program Manager, Docket Operations... Game, which does not afford time for public feedback on a safety zone that will be in effect only when... month of July, the Alaska Department of Fish and Game has announced fishing openers in the Port of...

  6. Memristive port-Hamiltonian control : Path-dependent damping injection in control of mechanical systems

    NARCIS (Netherlands)

    Doria-Cerezo, A.; van der Heijden, L.; Scherpen, J. M. A.

    2013-01-01

    This paper presents the use of the memristor as a new element for designing passivity-based controllers. From the port-Hamiltonian description of the electrical circuits with memristors, a target dynamics is assigned to the matching equation proposed by the methodology known as Interconnection and

  7. Three-port DC-DC converter with new integrated transformer for DC Distribution Systems

    DEFF Research Database (Denmark)

    Ouyang, Ziwei; Andersen, Michael A. E.

    2014-01-01

    A new integrated transformer for three-port dc-dc converter is proposed to overcome the power coupling effect existed in some known multiple inputs dc-dc converters. Orthogonal primary windings arrangement and in series connection of diagonal secondary Windings enables a fully power decoupling...

  8. ITER Upper Port Plug handling cask system assessment and design proposals

    NARCIS (Netherlands)

    Pustjens, J. W.; Friconneau, J. P.; Heemskerk, C. J. M.; Koning, J. F.; Martins, J. P.; Rosielle, Pcjn; Steinbuch, M.

    2011-01-01

    The current design of the ITER cask for Upper Port Plugs has been evaluated. Careful reduction of the number of mechanical degrees of freedom is an opportunity to relax the tolerances in the design, resulting in cost reduction and reliability increase. A new kinematical design for the tractor module

  9. BrainPort Technology Tongue Interface Characterization Tactical Underwater Navigation System (TUNS)

    Science.gov (United States)

    2008-06-01

    humans via neuro-stimulation of the tongue. Applications are numerous and include the BrainPort® balance device to assist patients with vestibular ...Set voltage to a constant value VR Set voltage to a register value RV Set a voltage register value RA Set an address register value TU Set

  10. Risk of infection due to medical interventions via central venous catheters or implantable venous access port systems at the middle port of a three-way cock: luer lock cap vs. luer access split septum system (Q-Syte).

    Science.gov (United States)

    Pohl, Fabian; Hartmann, Werner; Holzmann, Thomas; Gensicke, Sandra; Kölbl, Oliver; Hautmann, Matthias G

    2014-01-25

    Many cancer patients receive a central venous catheter or port system prior to therapy to assure correct drug administration. Even appropriate hygienic intervention maintenance carries the risk of contaminating the middle port (C-port) of a three-way cock (TWC), a risk that increases with the number of medical interventions. Because of the complexity of the cleaning procedure with disconnection and reconnection of the standard luer lock cap (referred as "intervention"), we compared luer lock caps with a "closed access system" consisting of a luer access split septum system with regard to process optimization (work simplification, process time), efficiency (costs) and hygiene (patient safety). For determination of process optimization the workflow of an intervention according to the usual practice and risks was depicted in a process diagram. For determining the actual process costs, we analyzed use of material and time parameters per intervention and used the process parameters for programming the process into a simulation run (n = 1000) to determine the process costs as well as their differences (ACTUAL vs. NOMINAL) within the framework of a discrete event simulation.Additionally cultures were carried out at the TWC C-ports to evaluate possible contamination. With the closed access system, the mean working time of 5.5 minutes could be reduced to 2.97 minutes. The results for average process costs (labour and material costs per use) were 3.92 € for luer lock caps and 2.55 € for the closed access system. The hypothesis test (2-sample t-test, CI 0.95, p-value<0.05) confirmed the significance of the result.In 50 reviewed samples (TWC's), the contamination rate for the luer lock cap was 8% (4 out of 50 samples were positive), the contamination rate of the 50 samples with the closed access system was 0%.Possible hygienic risks (related to material, surroundings, staff handling) could be reduced by 65.38%. In the present research, the closed access system with a

  11. Faux Pas Test in schizophrenic patients

    Directory of Open Access Journals (Sweden)

    Juliana Negrão

    2016-03-01

    Full Text Available ABSTRACT Objective The aim of this study is to validate the adult version of “Faux Pas Recognition Test” created by Stone and colleagues (1998 as a reliable instrument assess and discriminate social cognition among schizophrenia patients and healthy controls. Methods This is a cross-sectional study with a total of 196 participants (mean age = 26.45; CI (95% [25.10; 27.83] 51% male. From those, 44 (22.4% patients with schizophrenia and 152 (77.6% healthy controls. The participants answered a short version of the Faux Pas Recognition Test, composed by 10 stories. Results Significant differences were found between both groups regarding their scores on Faux Pas Recognition Test (p = 0.003. Patients with schizophrenia had lower score, compared to healthy controls. Story 14 was the best to distinguish both groups, and Story 16, the worst. Among the questions of Faux Pas stories, the one related to intuition presented the most significant difference between the groups (p = 0.001, followed by the one related to understanding (p = 0.003. Conclusion The Brazilian version of the Faux Pas Recognition Test is a valid test to assess social cognition in schizophrenia and can be an important instrument to be used on the clinical practice.

  12. Pressure Regulator With Internal Ejector Circulation Pump, Flow and Pressure Measurement Porting, and Fuel Cell System Integration Options

    Science.gov (United States)

    Vasquez, Arturo

    2011-01-01

    An advanced reactant pressure regulator with an internal ejector reactant circulation pump has been developed to support NASA's future fuel cell power systems needs. These needs include reliable and safe operation in variable-gravity environments, and for exploration activities with both manned and un manned vehicles. This product was developed for use in Proton Exchange Membrane Fuel Cell (PEMFC) power plant reactant circulation systems, but the design could also be applied to other fuel cell system types, (e.g., solid-oxide or alkaline) or for other gas pressure regulation and circulation needs. The regulator design includes porting for measurement of flow and pressure at key points in the system, and also includes several fuel cell system integration options. NASA has recognized ejectors as a viable alternative to mechanical pumps for use in spacecraft fuel cell power systems. The ejector motive force is provided by a variable, high-pressure supply gas that travels through the ejector s jet nozzle, whereby the pressure energy of the fluid stream is converted to kinetic energy in the gas jet. The ejector can produce circulation-to-consumption-flow ratios that are relatively high (2-3 times), and this phenomenon can potentially (with proper consideration of the remainder of the fuel cell system s design) be used to provide completely for reactant pre-humidification and product water removal in a fuel cell system. Specifically, a custom pressure regulator has been developed that includes: (1) an ejector reactant circulation pump (with interchangeable jet nozzles and mixer sections, gas-tight sliding and static seals in required locations, and internal fluid porting for pressure-sensing at the regulator's control elements) and (2) internal fluid porting to allow for flow rate and system pressure measurements. The fluid porting also allows for inclusion of purge, relief, and vacuum-breaker check valves on the regulator assembly. In addition, this regulator could also

  13. Ports Primer: 3.2 Port Governance

    Science.gov (United States)

    State and local governments are important players in port governance and in oversight of transportation projects that may affect ports. Private corporations may also play a role if they lease or own a terminal at a port.

  14. Port-Wine Stains

    Science.gov (United States)

    ... for the Flu Vaccine? Eating Disorders Arrhythmias Port-Wine Stains KidsHealth > For Parents > Port-Wine Stains Print ... Manchas de vino de oporto What Are Port-Wine Stains? A port-wine stain is a type ...

  15. A Collaborative Supply Chain Management System for a Maritime Port Logistics Chain

    Directory of Open Access Journals (Sweden)

    L.M. Ascencio

    2014-06-01

    Full Text Available In this article we propose a collaborative logistics framework for a Port Logistics Chain (PLC based on the principles of Supply Chain Management (SCM that rely on stakeholders integration and collaboration, providing a reference model for the inland coordination of the PLC. A comprehensive literature review was conducted, analyzing several cases in which SCM practices have been implemented as well as studies related to port development, governance, coordination and best practices associated. This background information was used to identify current gaps in logistics management practices and potential scopes of intervention within the PLC to suggest a redesign process and configure new structures under a collaborative scheme, following the guidelines of SCM.

  16. Application of ICT in systems management of the port SME sector

    Directory of Open Access Journals (Sweden)

    Jairo Augusto Cortes Méndez

    2016-06-01

    Full Text Available The project as a result of the research entitled "Impact of ICT in the organizational structure of SMEs in the port sector using virtual environments" under CONADI convening of the Cooperative University of Colombia, measures and verifies how Information Technology and Communication, ICT, have influenced the organizational structure of SMEs (Small and medium enterprises in the port sector, analyzing each of the perspectives and organizational components and how these can be adapted using ICT. As a general conclusion SMEs should be aware of the importance of ICT in the organizational and productive development as an added value and competitive advantage. The draft revision of the organizational theories, management indices, and experiences of use and impact of ICT in organizations was done. The methodology used is observational and evaluative type with technological development.

  17. Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus.

    Science.gov (United States)

    Shah, Neethu; Gaupp, Rosmarie; Moriyama, Hideaki; Eskridge, Kent M; Moriyama, Etsuko N; Somerville, Greg A

    2013-07-31

    The Per-Arnt-Sim (PAS) domain represents a ubiquitous structural fold that is involved in bacterial sensing and adaptation systems, including several virulence related functions. Although PAS domains and the subclass of PhoQ-DcuS-CitA (PDC) domains have a common structure, there is limited amino acid sequence similarity. To gain greater insight into the evolution of PDC/PAS domains present in the bacterial kingdom and staphylococci in specific, the PDC/PAS domains from the genomic sequences of 48 bacteria, representing 5 phyla, were identified using the sensitive search method based on HMM-to-HMM comparisons (HHblits). A total of 1,007 PAS domains and 686 PDC domains distributed over 1,174 proteins were identified. For 28 Gram-positive bacteria, the distribution, organization, and molecular evolution of PDC/PAS domains were analyzed in greater detail, with a special emphasis on the genus Staphylococcus. Compared to other bacteria the staphylococci have relatively fewer proteins (6-9) containing PDC/PAS domains. As a general rule, the staphylococcal genomes examined in this study contain a core group of seven PDC/PAS domain-containing proteins consisting of WalK, SrrB, PhoR, ArlS, HssS, NreB, and GdpP. The exceptions to this rule are: 1) S. saprophyticus lacks the core NreB protein; 2) S. carnosus has two additional PAS domain containing proteins; 3) S. epidermidis, S. aureus, and S. pseudintermedius have an additional protein with two PDC domains that is predicted to code for a sensor histidine kinase; 4) S. lugdunensis has an additional PDC containing protein predicted to be a sensor histidine kinase. This comprehensive analysis demonstrates that variation in PDC/PAS domains among bacteria has limited correlations to the genome size or pathogenicity; however, our analysis established that bacteria having a motile phase in their life cycle have significantly more PDC/PAS-containing proteins. In addition, our analysis revealed a tremendous amount of variation in the

  18. Adjuvant Hepatic Arterial Infusion Chemotherapy After Resection for Pancreatic Cancer Using Coaxial Catheter-Port System Compared with Conventional System

    Energy Technology Data Exchange (ETDEWEB)

    Hashimoto, Aya; Tanaka, Toshihiro, E-mail: toshihir@bf6.so-net.ne.jp [Nara Medical University, Department of Radiology (Japan); Sho, Masayuki [Nara Medical University, Department of Surgery (Japan); Nishiofuku, Hideyuki; Masada, Tetsuya; Sato, Takeshi; Marugami, Nagaaki [Nara Medical University, Department of Radiology (Japan); Anai, Hiroshi [Nara City Hospital, Department of Radiology (Japan); Sakaguchi, Hiroshi [Nara Prefectural Western Medical Center, Department of Radiology (Japan); Kanno, Masatoshi [Nara Medical University, Oncology Center (Japan); Tamamoto, Tetsuro; Hasegawa, Masatoshi [Nara Medical University, Department of Radiation Oncology (Japan); Nakajima, Yoshiyuki [Nara Medical University, Department of Surgery (Japan); Kichikawa, Kimihiko [Nara Medical University, Department of Radiology (Japan)

    2016-06-15

    PurposePrevious reports have shown the effectiveness of adjuvant hepatic arterial infusion chemotherapy (HAIC) in pancreatic cancer. However, percutaneous catheter placement is technically difficult after pancreatic surgery. The purpose of this study was to evaluate the feasibility and outcome of HAIC using a coaxial technique compared with conventional technique for postoperative pancreatic cancer.Materials and Methods93 consecutive patients who received percutaneous catheter-port system placement after pancreatectomy were enrolled. In 58 patients from March 2006 to August 2010 (Group A), a conventional technique with a 5-Fr indwelling catheter was used and in 35 patients from September 2010 to September 2012 (Group B), a coaxial technique with a 2.7-Fr coaxial catheter was used.ResultsThe overall technical success rates were 97.1 % in Group B and 86.2 % in Group A. In cases with arterial tortuousness and stenosis, the success rate was significantly higher in Group B (91.7 vs. 53.8 %; P = 0.046). Fluoroscopic and total procedure times were significantly shorter in Group B: 14.7 versus 26.7 min (P = 0.001) and 64.8 versus 80.7 min (P = 0.0051), respectively. No differences were seen in the complication rate. The 1 year liver metastasis rates were 9.9 % using the conventional system and 9.1 % using the coaxial system (P = 0.678). The overall median survival time was 44 months. There was no difference in the survival period between two systems (P = 0.312).ConclusionsThe coaxial technique is useful for catheter placement after pancreatectomy, achieving a high success rate and reducing fluoroscopic and procedure times, while maintaining the safety and efficacy for adjuvant HAIC in pancreatic cancer.

  19. Engineering issues on the diagnostic port integration in ITER upper port 18

    Energy Technology Data Exchange (ETDEWEB)

    Pak, Sunil, E-mail: paksunil@nfri.re.kr [National Fusion Research Institute, Gwahak-ro, Yuseong-gu, Daejeon (Korea, Republic of); Bertalot, Luciano [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Cheon, Mun Seong [National Fusion Research Institute, Gwahak-ro, Yuseong-gu, Daejeon (Korea, Republic of); Giacomin, Thibaud [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Heemskerk, Cock J.M.; Koning, Jarich F. [Heemskerk Innovative Technology, Merelhof 2, 2172 HZ Sassenheim (Netherlands); Lee, Hyeon Gon [National Fusion Research Institute, Gwahak-ro, Yuseong-gu, Daejeon (Korea, Republic of); Nemtcev, Grigorii [Institution “PROJECT CENTER ITER”, Akademika Kurchatova sq., Moscow (Russian Federation); Ronden, Dennis M.S. [FOM Institute DIFFER, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands); Seon, Chang Rae [National Fusion Research Institute, Gwahak-ro, Yuseong-gu, Daejeon (Korea, Republic of); Udintsev, Victor; Yukhnov, Nikolay [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Zvonkov, Alexander [Institution “PROJECT CENTER ITER”, Akademika Kurchatova sq., Moscow (Russian Federation)

    2016-11-01

    Highlights: • Diagnostic port integration in the upper port 18 of ITER is presented in order to house the three diagnostic systems. • Issue on the neutron shielding in the upper port 18 is addressed and the shut-down dose rate in the interspace is summarized. • The maintenance strategy in the upper port 18 is described. - Abstract: The upper port #18 (UP18) in ITER hosts three diagnostic systems: the neutron activation system, the Vacuum Ultra-Violet spectrometer system, and the vertical neutron camera. These diagnostics are integrated into three infrastructures in the port: the upper port plug, interspace support structure and port cell support structure. The port integration in UP18 is at the preliminary design stage and the current design of the infrastructure as well as the diagnostic integration is described here. The engineering issues related to neutron shielding and maintenance are addressed and the design approach is suggested.

  20. HomePort

    DEFF Research Database (Denmark)

    Le Guilly, Thibaut; Olsen, Petur; Ravn, Anders Peter

    2013-01-01

    Ambient Intelligence systems use many sensors and actuators, with a diversity of networks, protocols and technologies which makes it impossible to access the devices in a common manner. This paper presents the HomePort software, which provides an open source RESTful interface to heterogeneous...... sensor networks, allowing a simple unified access to virtually any kind of protocol using well known standards. HomePort includes means to provide event notification, as well as a tracing mechanism. The software is implemented and we report on initial experiments and provide an evaluation that shows...

  1. Setting the PAS, the role of circadian PAS domain proteins during environmental adaptation in plants.

    Science.gov (United States)

    Vogt, Julia H M; Schippers, Jos H M

    2015-01-01

    The per-ARNT-sim (PAS) domain represents an ancient protein module that can be found across all kingdoms of life. The domain functions as a sensing unit for a diverse array of signals, including molecular oxygen, small metabolites, and light. In plants, several PAS domain-containing proteins form an integral part of the circadian clock and regulate responses to environmental change. Moreover, these proteins function in pathways that control development and plant stress adaptation responses. Here, we discuss the role of PAS domain-containing proteins in anticipation, and adaptation to environmental changes in plants.

  2. A novel intracorporeal assembling robotic system for single-port laparoscopic surgery.

    Science.gov (United States)

    Petroni, Gianluigi; Niccolini, Marta; Menciassi, Arianna; Dario, Paolo; Cuschieri, Alfred

    2013-02-01

    Single-port laparoscopic surgery (SPLS) is a novel surgical approach consisting of a single umbilical incision through which multiple instruments are inserted, thus avoiding additional incisions necessary in traditional multi-port laparoscopic surgery. SPLS imposes a number of ergonomic restrictions on the surgeon. As a partial solution, several dedicated instruments, including hand-held manipulators with 6 degrees of freedom (DOF), have been introduced to overcome these manipulative restrictions. Robotics has the potential to overcome all of the ergonomic restrictions imposed by the SPLS approach. A novel, teleoperated, robotic platform has been developed. SPRINT (Single-Port lapaRoscopy bImaNual roboT) is a multiarm robot enabling bimanual interventions. The robotic arms are introduced into the abdomen through a cylindrical introducer. The surgeon is able to control the robot in a master-slave configuration through a dedicated console, allowing translation of the surgeon's hand movements to the end-effectors. Laboratory tests have been performed with the prototype by experienced surgeons for pick and place and suturing exercises. These confirmed the fast-learning curve with the use of the SPRINT robot. In the pick and place exercise, the mean successful peg transfer rate decreased from 97 s at the start to 50 s required for the transfer of the seventh peg. Thereafter, the slope of the curve decreased to 31 s after 17 transfers. The percentage error rate declined from an initial value 50 % to 25 % after 15 pegs had been transferred. In the intracorporeal suture test, needle passage and knot tying were completed by four surgeons in 314 s or less. A new surgical robot for SPLS has been developed, and its usability and efficacy have been demonstrated. The SPRINT may pave the way for the next generation of surgical robots, the arms of which are assembled inside the insufflated peritoneal cavity, providing full dexterity and manipulative ability with the SPLS approach.

  3. HomePort

    DEFF Research Database (Denmark)

    Madsen, Per Printz

    2009-01-01

    In the last couple of year's computer based home control systems are getting more and more common in modern homes. For instance these systems take care of light control, heat control and security systems.  The latest trend is to use wireless communication like Z-Wave and ZigBee to interconnect...... different components in these systems. One of the characteristics is that each system, like for instance heat and light, has their own specific way of using the communication system.   This paper describes a way to connect different home control systems through an intelligent gateway, called a Home......Port. The HomePort consists of a number of Subsystem communication drivers, a virtual communication layer, an interpreter and a PC- based compiler for a high level control language, called GIL (Gateway intelligence language). The focus in this paper will be on the upper two layers in the Home...

  4. The role of PAS kinase in PASsing the glucose signal.

    Science.gov (United States)

    Grose, Julianne H; Rutter, Jared

    2010-01-01

    PAS kinase is an evolutionarily conserved nutrient responsive protein kinase that regulates glucose homeostasis. Mammalian PAS kinase is activated by glucose in pancreatic beta cells, and knockout mice are protected from obesity, liver triglyceride accumulation, and insulin resistance when fed a high-fat diet. Yeast PAS kinase is regulated by both carbon source and cell integrity stress and stimulates the partitioning of glucose toward structural carbohydrate biosynthesis. In our current model for PAS kinase regulation, a small molecule metabolite binds the sensory PAS domain and activates the enzyme. Although bona fide PAS kinase substrates are scarce, in vitro substrate searches provide putative targets for exploration.

  5. Design and deployment of new fracturing port technology to increase stage number capability of openhole multistage systems

    Energy Technology Data Exchange (ETDEWEB)

    Roe, Tully; Seale, Rocky [Society of Petroleum Engineers (Canada); Snyder, Daniel [Packers Plus Energy Services (Canada)

    2011-07-01

    Since the mid-2000s, the use of horizontal drilling using the open hole multi-stage system (OHMS) has helped improve recovery rates in the Lower Huron shale, located in the United States. However OHMS also has some limitations in terms of the number of isolated stages and the repeatable fracturing port (RFP) was developed to remedy this. The aim of this paper is to present the benefits of using the RFP technology. Field trials performed in the Lower Huron shale and other formations are presented herein. Results showed that the RFP system was successful in increasing the number of potential stages in the trial runs carried out in North American formations. This paper pointed out that the RFP system can be used to obtain more efficient completions; one operator in the Lower Huron will be using this technology in their future wells.

  6. Synergy-Based Bilateral Port: A Universal Control Module for Tele-Manipulation Frameworks Using Asymmetric Master-Slave Systems.

    Science.gov (United States)

    Brygo, Anais; Sarakoglou, Ioannis; Grioli, Giorgio; Tsagarakis, Nikos

    2017-01-01

    Endowing tele-manipulation frameworks with the capability to accommodate a variety of robotic hands is key to achieving high performances through permitting to flexibly interchange the end-effector according to the task considered. This requires the development of control policies that not only cope with asymmetric master-slave systems but also whose high-level components are designed in a unified space in abstraction from the devices specifics. To address this dual challenge, a novel synergy port is developed that resolves the kinematic, sensing, and actuation asymmetries of the considered system through generating motion and force feedback references in the hardware-independent hand postural synergy space. It builds upon the concept of the Cartesian-based synergy matrix, which is introduced as a tool mapping the fingertips Cartesian space to the directions oriented along the grasp principal components. To assess the effectiveness of the proposed approach, the synergy port has been integrated into the control system of a highly asymmetric tele-manipulation framework, in which the 3-finger hand exoskeleton HEXOTRAC is used as a master device to control the SoftHand, a robotic hand whose transmission system relies on a single motor to drive all joints along a soft synergistic path. The platform is further enriched with the vision-based motion capture system Optitrack to monitor the 6D trajectory of the user's wrist, which is used to control the robotic arm on which the SoftHand is mounted. Experiments have been conducted with the humanoid robot COMAN and the KUKA LWR robotic manipulator. Results indicate that this bilateral interface is highly intuitive and allows users with no prior experience to reach, grasp, and transport a variety of objects exhibiting very different shapes and impedances. In addition, the hardware and control solutions proved capable of accommodating users with different hand kinematics. Finally, the proposed control framework offers a

  7. Evolution of PAS domains and PAS-containing genes in eukaryotes.

    Science.gov (United States)

    Mei, Qiming; Dvornyk, Volodymyr

    2014-08-01

    The PAS domains are signal modules, which are widely distributed in proteins across all kingdoms of life. They are common in photoreceptors and transcriptional regulators of eukaryotic circadian clocks q(bHLH-PAS proteins and PER in animals; PHY and ZTL in plants; and WC-1, 2, and VVD in fungi) and possess mainly protein-protein interaction and light-sensing functions. We conducted several evolutionary analyses of the PAS superfamily. Although the whole superfamily evolved primarily under strong purifying selection (average ω ranges from 0.0030 to 0.1164), some lineages apparently experienced strong episodic positive selection at some periods of the evolution. Although the PAS domains from different proteins vary in sequence and length, but they maintain a fairly conserved 3D structure, which is determined by only eight residues. The WC-1 and WC- 2, bHLH-PAS, and P er genes probably originated in the Neoproterozoic Era (1000-542 Mya), plant P hy and ZTL evolved in the Paleozoic (541-252 Mya), which might be a result of adaptation to the major climate and global light regime changes having occurred in those eras.

  8. Principal Ports and Facilities

    Data.gov (United States)

    California Department of Resources — The Principal Port file contains USACE port codes, geographic locations (longitude, latitude), names, and commodity tonnage summaries (total tons, domestic, foreign,...

  9. A Modified Triples Algorithm for Flush Air Data Systems that Allows a Variety of Pressure Port Configurations

    Science.gov (United States)

    Millman, Daniel R.

    2017-01-01

    Air Data Systems (FADS) are becoming more prevalent on re-entry vehicles, as evi- denced by the Mars Science Laboratory and the Orion Multipurpose Crew Vehicle. A FADS consists of flush-mounted pressure transducers located at various locations on the fore-body of a flight vehicle or the heat shield of a re-entry capsule. A pressure model converts the pressure readings into useful air data quantities. Two algorithms for converting pressure readings to air data have become predominant- the iterative Least Squares State Estimator (LSSE) and the Triples Algorithm. What follows herein is a new algorithm that takes advantage of the best features of both the Triples Algorithm and the LSSE. This approach employs the potential flow model and strategic differencing of the Triples Algorithm to obtain the defective flight angles; however, the requirements on port placement are far less restrictive, allowing for configurations that are considered optimal for a FADS.

  10. Availability of stereotactic radiotherapy with irregular ports (STRIP). Survey from database of pReference stereotactic system users group

    Energy Technology Data Exchange (ETDEWEB)

    Ohizumi, Yukio; Tamai, Hisashi; Imamiya, Satoshi; Akiba, Takeshi; Mori, Tomoyuki [Tokai Univ., Isehara, Kanagawa (Japan). School of Medicine; Seo, Makoto

    1999-04-01

    Stereotactic radiotherapy with irregular ports (STRIP) contributes to reduce normal tissue damage around irregular target by using conformal collimator. The availability of STRIP was surveyed on the database of pReference stereotactic system users group. During the last three years, STRIP was used in 44% of patients with stereotactic irradiation. The high availability was seen in patients with astrocytoma (55%), H and N cancer (50%), pituitary adenoma (50%), and AVM (44%). In sites, temporal lobe (46%), base of skull (43%), and brain stem (38%). In target volume, 4 cc-13.5 cc (47%), 13.5 cc-35 cc (66%), and >35 cc (83%). In target regularity, {+-}4 mm-{+-}8 mm (43%) and >{+-}8 mm (75%). The diameter of target and irregularity correlated strongly. Targets with 3 cm in diameter and >{+-}4 mm of irregularity were recommended to treat with irregular pots. Hand-made irregular-shaped collimators were easily made and not expensive in cost. (author)

  11. Le droit de ne pas croire

    Directory of Open Access Journals (Sweden)

    Pascal Engel

    2012-07-01

    Full Text Available Le principe des raisons suffisantesBertrand Russell écrit, non sans une sérieuse dose d’ironie :Je voudrais proposer à la considération bienveillante du lecteur une doctrine qui, je le crains, peut apparaître comme étant brutalement paradoxale et subversive. La doctrine en question est : il n’est pas souhaitable de croire une proposition quand on n’a aucune raison que ce soit de supposer qu’elle soit vraie. Je dois bien sûr admettre que si une telle opinion devenait commune, elle transformera...

  12. Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission.

    Science.gov (United States)

    Dupré, Elian; Wohlkonig, Alexandre; Herrou, Julien; Locht, Camille; Jacob-Dubuisson, Françoise; Antoine, Rudy

    2013-07-24

    In bacteria, signal-transduction two-component systems are major players for adaptation to environmental stimuli. The perception of a chemical or physical signal by a sensor-kinase triggers its autophosphorylation. The phosphoryl group is then transferred to the cognate response regulator, which mediates the appropriate adaptive response. Virulence of the whooping cough agent Bordetella pertussis is controlled by the two-component system BvgAS. Atypically, the sensor-kinase BvgS is active without specific stimuli at 37°C in laboratory conditions and is inactivated by the addition of negative chemical modulators. The structure of BvgS is complex, with two tandem periplasmic Venus flytrap domains and a cytoplasmic PAS domain that precedes the kinase domain, which is followed by additional phosphotransfer domains. PAS domains are small, ubiquitous sensing or regulatory domains. The function of the PAS domain in BvgS remains unknown. We showed that recombinant BvgS PAS proteins form dimers that are stabilized by α helical regions flanking the PAS core. A structural model of the PAS domain dimer was built and probed by site-directed mutagenesis and by biochemical and functional analyses. Although we found no ligands for the PAS domain cavity, its integrity is required for signaling. We also showed that the structural stability of the PAS core and its proper coupling to its flanking N- and C-terminal α helices are crucial for BvgS activity. We propose that a major function of the BvgS PAS domain is to maintain conformational signals arising from mechanical strain generated by the periplasmic domain. The tight structure of the PAS core and its connections with the upstream and downstream helices ensure signaling to the kinase domain, which determines BvgS activity. Many mild substitutions that map to the PAS domain keep BvgS active but make it unresponsive to negative modulators, supporting that modulation increases conformational strain in the protein.

  13. PAs in orthopedics in the VHA's community-based outpatient clinics.

    Science.gov (United States)

    Reed, Daniel O; Hooker, Roderick S

    2017-04-01

    In the Veterans Health Administration (VHA) system, most orthopedic care takes place in the VA medical centers (VAMCs). Because most patients receiving orthopedic care were referred by adult medicine providers, more widely deploying physician assistants (PAs) in orthopedic medicine might help offset this workload. An orthopedic medicine demonstration project recruited, trained, and positioned PAs in community-based outpatient clinics (CBOCs) to improve access to care. The project involved surgeons at the Houston VAMC instructing five newly employed PAs in a wide range of orthopedic evaluation and management strategies before their assignment to a CBOC. An administrative assessment compared encounter data pre- and postproject (2012 and 2014) to determine if this strategy modified orthopedic workload and improved patient access to care. By 2014, orthopedic patient visit volume had increased 31%-10% at the VAMC and 21% at the five CBOCs. Overall, the five deployed PAs managed 28% of all orthopedic encounters spread over 1 year and only 3.2% of visits required VAMC referral for further evaluation or treatment. During the project, the total volume of patient visits increased throughout the Houston VAMC region but access to care for this specialty service also increased, with more veteran musculoskeletal care being met at the five CBOCs, off-loading visit demand centrally. The adaptability and flexibility of new roles has been identified as one of the defining characteristics of PAs. That the VHA can take advantage of this role malleability suggests that employing PAs is useful in meeting medical service needs of veterans.

  14. Spanish validation of the Premorbid Adjustment Scale (PAS-S).

    Science.gov (United States)

    Barajas, Ana; Ochoa, Susana; Baños, Iris; Dolz, Montse; Villalta-Gil, Victoria; Vilaplana, Miriam; Autonell, Jaume; Sánchez, Bernardo; Cervilla, Jorge A; Foix, Alexandrina; Obiols, Jordi E; Haro, Josep Maria; Usall, Judith

    2013-02-01

    The Premorbid Adjustment Scale (PAS) has been the most widely used scale to quantify premorbid status in schizophrenia, coming to be regarded as the gold standard of retrospective assessment instruments. To examine the psychometric properties of the Spanish version of the PAS (PAS-S). Retrospective study of 140 individuals experiencing a first episode of psychosis (n=77) and individuals who have schizophrenia (n=63), both adult and adolescent patients. Data were collected through a socio-demographic questionnaire and a battery of instruments which includes the following scales: PAS-S, PANSS, LSP, GAF and DAS-sv. The Cronbach's alpha was performed to assess the internal consistency of PAS-S. Pearson's correlations were performed to assess the convergent and discriminant validity. The Cronbach's alpha of the PAS-S scale was 0.85. The correlation between social PAS-S and total PAS-S was 0.85 (pPAS-S and total PAS-S it was 0.53 (pPAS-S scale, with a significance value less than 0.001. There was a relationship between negative symptoms and social PAS-S (0.20, pPAS-S (0.22, pPAS-S. However, there was a correlation between academic PAS-S and general subscale of the PANSS (0.19, pPAS-S was related to disability measures (DAS-sv); and academic PAS-S showed discriminant validity with most of the variables of social functioning. PAS-S did not show association with the total LSP scale (discriminant validity). The Spanish version of the Premorbid Adjustment Scale showed appropriate psychometric properties in patients experiencing a first episode of psychosis and who have a chronic evolution of the illness. Moreover, each domain of the PAS-S (social and academic premorbid functioning) showed a differential relationship to other characteristics such as psychotic symptoms, disability or social functioning after onset of illness. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Synergy-Based Bilateral Port: A Universal Control Module for Tele-Manipulation Frameworks Using Asymmetric Master–Slave Systems

    Science.gov (United States)

    Brygo, Anais; Sarakoglou, Ioannis; Grioli, Giorgio; Tsagarakis, Nikos

    2017-01-01

    Endowing tele-manipulation frameworks with the capability to accommodate a variety of robotic hands is key to achieving high performances through permitting to flexibly interchange the end-effector according to the task considered. This requires the development of control policies that not only cope with asymmetric master–slave systems but also whose high-level components are designed in a unified space in abstraction from the devices specifics. To address this dual challenge, a novel synergy port is developed that resolves the kinematic, sensing, and actuation asymmetries of the considered system through generating motion and force feedback references in the hardware-independent hand postural synergy space. It builds upon the concept of the Cartesian-based synergy matrix, which is introduced as a tool mapping the fingertips Cartesian space to the directions oriented along the grasp principal components. To assess the effectiveness of the proposed approach, the synergy port has been integrated into the control system of a highly asymmetric tele-manipulation framework, in which the 3-finger hand exoskeleton HEXOTRAC is used as a master device to control the SoftHand, a robotic hand whose transmission system relies on a single motor to drive all joints along a soft synergistic path. The platform is further enriched with the vision-based motion capture system Optitrack to monitor the 6D trajectory of the user’s wrist, which is used to control the robotic arm on which the SoftHand is mounted. Experiments have been conducted with the humanoid robot COMAN and the KUKA LWR robotic manipulator. Results indicate that this bilateral interface is highly intuitive and allows users with no prior experience to reach, grasp, and transport a variety of objects exhibiting very different shapes and impedances. In addition, the hardware and control solutions proved capable of accommodating users with different hand kinematics. Finally, the proposed control framework offers a

  16. Port and Harbor Security

    Energy Technology Data Exchange (ETDEWEB)

    Saito, T; Guthmuller, H; DeWeert, M

    2004-12-15

    Port and Harbor Security is a daunting task to which optics and photonics offers significant solutions. We are pleased to report that the 2005 Defense and Security Symposium (DSS, Orlando, FL) will include reports on active and passive photonic systems operating from both airborne and subsurface platforms. In addition to imaging techniques, there are various photonic applications, such as total internal reflection fluorescence (TIRF), which can be used to ''sniff'' for traces of explosives or contaminants in marine. These non-imaging technologies are beyond the scope of this article, but will also be represented at DSS 2005. We encourage colleagues to join our technical group to help us to make our ports and harbors safer and more secure.

  17. Flat-port connectors

    KAUST Repository

    Alrashed, Mohammed

    2017-05-26

    Disclosed are various embodiments for connectors used with electronic devices, such as input and/or output ports to connect peripheral equipment or accessories. More specifically, various flat-port are provided that can be used in place of standard connectors including, but not limited to, audio jacks and Universal Serial Bus (USB) ports. The flat-port connectors are an alternate connection design to replace the traditional receptacle port (female-port), making the device more sealed creation more dust and water resistant. It is unique in the way of using the outer surfaces of the device for the electrical connection between the ports. Flat-port design can allow the manufacture of extremely thin devices by eliminating the side ports slots that take a lot of space and contribute to the increase thickness of the device. The flat-port receptacle improves the overall appearance of the device and makes it more resistant to dust and water.

  18. Sustainable development model for nautical tourism ports

    OpenAIRE

    Alen Jugović; Mirjana Kovačić; Ana Hadžić

    2011-01-01

    Nautical tourism ports make an open, dynamic and complex system which has been rapidly evolving; this is the reason why the development of this system requires continual monitoring and research. The existing models and development plans concerning nautical tourism ports do not provide for a systematic qualitative and quantitative development of nautical tourism, thus contributing to economical inefficiency likely to cause even ecological imbalance. The more so if nautical ports are regarded a...

  19. Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR

    Science.gov (United States)

    Hao, Nan; Whitelaw, Murray L.; Shearwin, Keith E.; Dodd, Ian B.; Chapman-Smith, Anne

    2011-01-01

    The basic helix–loop–helix (bHLH).PAS dimeric transcription factors have crucial roles in development, stress response, oxygen homeostasis and neurogenesis. Their target gene specificity depends in part on partner protein choices, where dimerization with common partner Aryl hydrocarbon receptor nuclear translocator (Arnt) is an essential step towards forming active, DNA binding complexes. Using a new bacterial two-hybrid system that selects for loss of protein interactions, we have identified 22 amino acids in the N-terminal PAS domain of Arnt that are involved in heterodimerization with aryl hydrocarbon receptor (AhR). Of these, Arnt E163 and Arnt S190 were selective for the AhR/Arnt interaction, since mutations at these positions had little effect on Arnt dimerization with other bHLH.PAS partners, while substitution of Arnt D217 affected the interaction with both AhR and hypoxia inducible factor-1α but not with single minded 1 and 2 or neuronal PAS4. Arnt uses the same face of the N-terminal PAS domain for homo- and heterodimerization and mutational analysis of AhR demonstrated that the equivalent region is used by AhR when dimerizing with Arnt. These interfaces differ from the PAS β-scaffold surfaces used for dimerization between the C-terminal PAS domains of hypoxia inducible factor-2α and Arnt, commonly used for PAS domain interactions. PMID:21245039

  20. ePORT, NASA's Computer Database Program for System Safety Risk Management Oversight (Electronic Project Online Risk Tool)

    Science.gov (United States)

    Johnson, Paul W.

    2008-01-01

    ePORT (electronic Project Online Risk Tool) provides a systematic approach to using an electronic database program to manage a program/project risk management processes. This presentation will briefly cover the standard risk management procedures, then thoroughly cover NASA's Risk Management tool called ePORT. This electronic Project Online Risk Tool (ePORT) is a web-based risk management program that provides a common framework to capture and manage risks, independent of a programs/projects size and budget. It is used to thoroughly cover the risk management paradigm providing standardized evaluation criterion for common management reporting, ePORT improves Product Line, Center and Corporate Management insight, simplifies program/project manager reporting, and maintains an archive of data for historical reference.

  1. Strategic port development

    DEFF Research Database (Denmark)

    Olesen, Peter Bjerg; Dukovska-Popovska, Iskra; Hvolby, Hans-Henrik

    2014-01-01

    heavily focussed on larger ports. The smaller ports do not have the same resources and knowledge to implement the techniques that have been developed for the larger ports, as these methods often are very complex in nature. Smaller ports do not have the economics of scale to support more complex......While large global ports are recognised as playing a central role in many supply chains as logistic gateways, smaller regional ports have been more stagnant and have not reached the same level of development as the larger ports. The research literature in relation to port development is also...... developments. This paper examines a series of models from the port development literature and then proposes an approach for conceptualizing the strategic development of a port’s collaboration with local operators and the local hinterland based on connected development steps. The paper is based on a literature...

  2. Strategic Mobility 21, Inland Port - Multi-Modal Terminal Operating System Design Specification

    National Research Council Canada - National Science Library

    Mallon, Lawrence G; Dougherty, Edmond J

    2007-01-01

    ...) Specification identifies technical and functional requirements for procuring and integrating services required for a multi-modal node operating software system operating within a Service Oriented Architecture (SOA...

  3. Systems Approach to Defeating Maritime Improvised Explosive Devices in U.S. Ports

    Science.gov (United States)

    2008-12-01

    xxiii I. INTRODUCTION TO MARITIME IMPROVISED EXPLOSIVE DEVICES AND THE SYSTEMS ENGINEERING DESIGN PROCESS ........................... 1...SIGHT MARSEC MARITIME SECURITY MCDM MULTI-CRITERIA DECISION MAKING MCM MINE COUNTER-MEASURE(S) MCMUSV MINE COUNTER-MEASURES UNMANNED...INTENTIONALLY LEFT BLANK 1 I. INTRODUCTION TO MARITIME IMPROVISED EXPLOSIVE DEVICES AND THE SYSTEMS ENGINEERING DESIGN PROCESS (SEDP) 1. PROJECT TEAM

  4. GlobePort Faces Global Business Challenges--Assessing the Organizational Side of Information Systems Projects

    Science.gov (United States)

    Ghosh, Biswadip

    2011-01-01

    Published studies have reported that Information System (IS) projects succeed or fail based on how effectively the organizational issues were understood and addressed in the specification, development and implementation stages of the project. This is particularly true in the design and delivery of Inter-Organizational Systems (IOS) that can affect…

  5. Energy-Shaping of Port-Controlled Hamiltonian Systems by Interconnection

    NARCIS (Netherlands)

    Ortega, Romeo; Schaft, Arjan van der; Maschke, Bernhard; Escobar, Gerardo

    1999-01-01

    Passivity-based control (PBC) has shown to be very powerful to design robust controllers for physical systems described by Euler-Lagrange (EL) equations of motion. The application of PBC in regulation problems of mechanical systems yields controllers that have a clear physical interpretation in

  6. PAS kinase: a nutrient sensing regulator of glucose homeostasis.

    Science.gov (United States)

    DeMille, Desiree; Grose, Julianne H

    2013-11-01

    Per-Arnt-Sim (PAS) kinase (PASK, PASKIN, and PSK) is a member of the group of nutrient sensing protein kinases. These protein kinases sense the energy or nutrient status of the cell and regulate cellular metabolism appropriately. PAS kinase responds to glucose availability and regulates glucose homeostasis in yeast, mice, and man. Despite this pivotal role, the molecular mechanisms of PAS kinase regulation and function are largely unknown. This review focuses on what is known about PAS kinase, including its conservation from yeast to man, identified substrates, associated phenotypes and role in metabolic disease. © 2013 International Union of Biochemistry and Molecular Biology.

  7. A Well-Controlled Nucleus Pulposus Tissue Culture System with Injection Port for Evaluating Regenerative Therapies.

    Science.gov (United States)

    Arkesteijn, Irene T M; Mouser, Vivian H M; Mwale, Fackson; van Dijk, Bart G M; Ito, Keita

    2016-05-01

    In vitro evaluation of nucleus pulposus (NP) tissue regeneration would be useful, but current systems for NP culture are not ideal for injections. The aim of this study was to develop a long-term culture system for NP tissue that allows injections of regenerative agents. Bovine caudal NPs were harvested and placed in the newly designed culture system. After equilibration of the tissue to 0.3 MPa the volume was fixed and the tissue was cultured for 28 days. The cell viability and extracellular matrix composition remained unchanged during the culture period and gene expression profiles were similar to those obtained in earlier studies. Furthermore, to test the responsiveness of bovine caudal NPs in the system, samples were cultured for 4 days and injected twice (day 1 and 3) with (1) PBS, (2) Link-N, for regeneration, and (3) TNF-α, for degeneration. It was shown that TNF-α increased COX2 gene expression, whereas no effect of Link-N was detected. In conclusion, the newly designed system allows long-term culture of NP tissue, wherein tissue reactions to injected stimulants can be observed.

  8. A novel implantable catheter system with transcutaneous port for intermittent convection-enhanced delivery of carboplatin for recurrent glioblastoma.

    Science.gov (United States)

    Barua, Neil U; Hopkins, Kirsten; Woolley, Max; O'Sullivan, Stephen; Harrison, Rob; Edwards, Richard J; Bienemann, Alison S; Wyatt, Marcella J; Arshad, Azeem; Gill, Steven S

    2016-01-01

    Inadequate penetration of the blood-brain barrier (BBB) by systemically administered chemotherapies including carboplatin is implicated in their failure to improve prognosis for patients with glioblastoma. Convection-enhanced delivery (CED) of carboplatin has the potential to improve outcomes by facilitating bypass of the BBB. We report the first use of an implantable CED system incorporating a novel transcutaneous bone-anchored port (TBAP) for intermittent CED of carboplatin in a patient with recurrent glioblastoma. The CED catheter system was implanted using a robot-assisted surgical method. Catheter targeting accuracy was verified by performing intra-operative O-arm imaging. The TBAP was implanted using a skin-flap dermatome technique modeled on bone-anchored hearing aid surgery. Repeated infusions were performed by attaching a needle administration set to the TBAP. Drug distribution was monitored with serial real-time T2-weighted magnetic resonance imaging (MRI). All catheters were implanted to within 1.5 mm of their planned target. Intermittent infusions of carboplatin were performed on three consecutive days and repeated after one month without the need for further surgical intervention. Infused volumes of 27.9 ml per day were well tolerated, with the exception of a single seizure episode. Follow-up MRI at eight weeks demonstrated a significant reduction in the volume of tumor enhancement from 42.6 ml to 24.6 ml, and was associated with stability of the patient's clinical condition. Reduction in the volume of tumor enhancement indicates that intermittent CED of carboplatin has the potential to improve outcomes in glioblastoma. The novel technology described in this report make intermittent CED infusion regimes an achievable treatment strategy.

  9. Designing Agent Based Inter-Organizational Systems: Business and IOS alignment in the Port of Rotterdam

    NARCIS (Netherlands)

    Douma, A.M.; Moonen, Hans; van Hillegersberg, Jos; van de Rakt, Bastiaan; Schutten, Johannes M.J.

    2006-01-01

    Inter-organizational systems (IOS) hold high promises for improving the coordination of activities in logistics business networks. Although several successful IOS have been implemented, success is scarce in situations where different parties like to keep a large degree of autonomy, are hardly

  10. Port-Hamiltonian and power-based integral control of a manipulator system

    NARCIS (Netherlands)

    Dirksz, Daniel; Scherpen, Jacquelien M.A.

    2011-01-01

    In industrial applications integral control is often used in controllers to counteract the effects of disturbances and other uncertainties. The integral action compensates for steady-state errors caused by such uncertainties. However, for nonlinear systems, when adding an integrator in the classical

  11. US Ports of Entry

    Data.gov (United States)

    Department of Homeland Security — HSIP Non-Crossing Ports-of-Entry A Port of Entry is any designated place at which a CBP officer is authorized to accept entries of merchandise to collect duties, and...

  12. Port Hinterland Modelling Based on Port Choice

    Directory of Open Access Journals (Sweden)

    Tomaž Kramberger

    2015-06-01

    Full Text Available This paper presents a new approach for hinterland modelling based on the results of port choice modelling. The paper follows the idea that the shippers’ port choice is a trade-off between various objective and subjective factors. The presented model tackles the problem by applying the AHP method in order to obtain ports’ preference rates based on subjective factors, and combine them with objective factors, which include port operation costs, sailing times, and land transport costs using MILP. The ports’ hinterlands are modelled by finding the optimal port of choice for different locations across Europe and merging the identical results. The model can be used in order to produce captive hinterland of ports and can also be exploited in order to analyse how changes in the traffic infrastructure influence the size of hinterlands.

  13. Getting Port Governance Right

    DEFF Research Database (Denmark)

    de Langen, Peter; Saragiotis, Periklis

    2018-01-01

    This chapter discusses the relevance of ports for economic development and next identifies port governance as a critical determinant of a well-functioning port industry. While in the past decades privately owned terminal operating companies have emerged and contributed to more efficient supply ch...

  14. Theoretical and Experimental Studies of a Switched Inertance Hydraulic System in a Four-Port High-Speed Switching Valve Configuration

    Directory of Open Access Journals (Sweden)

    Min Pan

    2017-06-01

    Full Text Available The switched inertance hydraulic system (SIHS is a novel high-bandwidth and energy-efficient digital device which can adjust or control flow and pressure by a means that does not rely on throttling the flow and dissipation of power. An SIHS can provide an efficient step-up or step-down of pressure or flow rate by using a digital control signal. In this article, analytical models of an SIHS in a four-port high-speed switching valve configuration are proposed, and the system dynamics and performance are investigated theoretically and experimentally. The flow responses, system characteristics, and power consumption can be predicted effectively and accurately by using the proposed models, which were validated by comparing with experiments and with numerical simulation. The four-port configuration is compared with the three-port configuration, and it is concluded that the former one is less efficient for valves of the same size, but provides a bi-direction control capability. As bi-direction control is a common requirement, this constitutes an important contribution to the development of efficient digital hydraulics.

  15. PAs in primary care: Current status and workforce implications.

    Science.gov (United States)

    Coplan, Bettie; Smith, Noel; Cawley, James F

    2017-09-01

    Understanding the PA primary care workforce is an initial step toward greater use of primary care PAs in new healthcare delivery models. This study sought to describe primary care PA practice as it compares with PA practice in other specialties. Data from two 2015 national American Academy of Physician Assistants surveys were analyzed using descriptive statistics. Statistically significant differences between primary care and specialty PAs were assessed using tests of column proportions and tests of column means. Compared with PAs in specialties, primary care PAs were older, saw more patients per week, and spent less time consulting with physicians. In addition, higher percentages were Hispanic, had a record of military service, and had plans to leave their specialty or retire. Primary care PAs appear to possess unique strengths; however, challenges to maintaining a primary care PA workforce are substantial.

  16. Evaluating the lifestyles of physicians and PAs in orthopedics.

    Science.gov (United States)

    Shannon, Katherine M; Merenstein, Daniel J

    2017-01-01

    Limited current research is available comparing job satisfaction and lifestyles of physicians and physician assistants (PAs). Given the professional similarities and the upward trend in employment for both professions, this research is important in educating future professionals and employers. This study examined job contentment among orthopedic physicians and PAs. A cross-sectional survey was designed to assess career and lifestyle satisfaction. The survey was e-mailed to orthopedic clinics across the United States. 27 PAs and 50 physicians completed the survey. Compared with physicians, PAs were more likely to recommend their career and to desire to switch specialties. Physicians reported a higher level of agreement that the professional schedule overshadows personal life, and that the stress and demand of the profession impair personal health. PAs in orthopedics self-reported a higher lifestyle satisfaction than physicians. One specialty was examined and larger, more diverse studies should be conducted.

  17. A Systems Analysis View of the Vietnam War: 1965-1972. Volume 12. Construction and Port Operations in South Vietnam

    Science.gov (United States)

    1975-02-01

    cargo sector o0 theport reached a crisis point in December 1966, when the discharge fell to a record low of 102,000 S/T and the backlog soared to a...CONFIDENTIAL SLG1 ?Orr As the taell and attached charts Indicate, the A!Di.Ccmmercial -argo sector of the Saigon port is in its best conditio- in a year...1967. The U. S. is now discharging 45% of the AID/ Comercial cargo in the Saigon port. Perhaps it is now timely to reappraise the continued need t

  18. Pasca-Islamisme dalam PAS: Analisis terhadap Kesan Tahalluf Siyasi

    Directory of Open Access Journals (Sweden)

    MUHAMMAD FAIZ MUKMIN ABDUL MUTALIB

    2015-12-01

    Full Text Available This study discusses the impact of post-Islamism in the Parti Islam Se-Malaysia (PAS, specifically on tahalluf siyasi (political alliance with Pakatan Rakyat (People Coalition. Post Islamism is a contemporary Islamist school of thought with regard to politics. The characteristics of post-Islamism such as toleration, participation and inclusivism has greatly influenced the modus operandi of the Islamic movement including PAS. Inclusiveness in post-Islamism had motivated PAS in having political coalition with more liberal parties such as Parti Keadilan Rakyat (PKR and Democratic Action Party (DAP. Post-Islamism as popularised by Asef Bayat was established on Western knowledge narratives, therefore such study as this should be done in order to recognise its negative impacts. To achieve this objective, the researchers used qualitative method through the process of collecting by scrutinising and analysing related data on the discourse of post-Islamism. The result of the study shows that PAS has been affected by the post-Islamism. The impact of post-Islamism in PAS however shows that PAS did not play dominant role in the Coalition throughout the political alliance. Besides, PAS also compromised a lot with its principles including its Islamic principles. Post-Islamism had also affected PAS in reducing the Muslims vote to PAS because of their support for DAP. This study therefore exposed the negative sides of post-Islamism to Islamic movement. With current development in PAS, it is hoped that this exposure will consult the Islamic movements in critically weighing their support to any kind of ideas particularly from the West.

  19. Correlating the content and context of PAS 55 with the ISO 55000 series

    Directory of Open Access Journals (Sweden)

    Van den Honert, A. F.

    2013-08-01

    Full Text Available The ISO 55000 series is soon to supersede PAS 55 as the most recognised international standard for asset management. A correlation of the content and context of PAS 55 with the ISO 55000 series is required to assist organisations with the transition. After analysis of the structures, similarities, differences, and omissions of the two standards, a map was created to correlate the summarised content and context. The map established that, although both sets of standards have a similar structural framework, the ISO 55000 series is a more comprehensive and detailed standard, creating a clearer way to implement an asset management system within an organisation.

  20. Deepwater Ports in US waters as of August 2013

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Deepwater Port Licensing Program is the application process designed to promote the construction of LNG and oil deepwater ports. This license system was...

  1. Shipping emissions in ports

    OpenAIRE

    Merk, Olaf

    2014-01-01

    Shipping emissions in ports are substantial, accounting for 18 million tonnes of CO2 emissions, 0.4 million tonnes of NOx, 0.2 million of SOx and 0.03 million tonnes of PM10 in 2011. Around 85% of emissions come from containerships and tankers. Containerships have short port stays, but high emissions during these stays. Most of CO2 emissions in ports from shipping are in Asia and Europe (58%), but this share is low compared to their share of port calls (70%). European ports have much less emi...

  2. Technical developments: use of targeting guide wire in left subclavian puncture during percutaneous implantation of port-catheter systems using the catheter tip fixation method

    Energy Technology Data Exchange (ETDEWEB)

    Yamagami, Takuji; Kato, Takeharu; Nakamura, Toshiyuki; Iida, Shigeharu; Tanaka, Osamu; Nishimura, Tsunehiko [Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajii, Kawaramachi-Hirokoji, Kamigyo, Kyoto 602-8566 (Japan)

    2003-04-01

    Our objective was to evaluate the feasibility and safety of a new method in approaching the access route percutaneously for the implantable port-catheter system for repeated hepatic arterial infusion chemotherapy. Fifteen patients underwent port-catheter system placement via the left subclavian artery with the catheter tip fixed within the gastroduodenal artery with embolic materials and a catheter side hole opening to the common hepatic artery. Before port-catheter placement, the right gastric artery was embolized via the femoral catheter access. Then a 0.035-in. guide wire was inserted from the right femoral artery to the left subclavian artery. The guide wire was left in place during puncture by the needle as an access route for catheter placement. At the time of puncture, the tip of the puncture needle was aimed at the guide wire placed in the subclavian artery beforehand. In all 15 patients the procedure was successfully completed in a reasonable time (mean time 95.0 min, range 50-240 min). Complications occurred in two patients: a transient numbness of the arm in 1 patient and a mild hematoma detected in the subcutaneous pocket in another patient. This experience indicates the possibility of using a targeting guide wire in puncture of the subclavian artery as an access route for catheter placement. (orig.)

  3. Sea freight - Antwerp Port

    Directory of Open Access Journals (Sweden)

    NEACSU Nicoleta Andreea

    2017-01-01

    Full Text Available Shipping plays a vital role in achieving the movement of goods, both in terms of quantity and efficiency. This paper presents the role and advantages of shipping in the global economy and analyzes the development and Antwerp Port activity. Currently, the second most important trading port in Europe and 14th in the ranking of most important ports that handle containers worldwide, the Port of Antwerp, Belgium is a port in the heart of Europe, accessible to large sized vessels. 200 years of constructing infrastructure and logistics around the central location, as well as pressure from Rotterdam, that had an impact on the competitiveness of the port of Antwerp, all this led the port to occupy a leading position in the top rankings.

  4. INSTITUTIONAL AND MANAGEMENT STRUCTURE OF RUSSIAN ARCTIC SEA PORTS

    Directory of Open Access Journals (Sweden)

    P. A. Bryzgalov

    2012-01-01

    Full Text Available Institutional and management structure of any sea port is a system of interaction between commercial enterprises engaged in cargo operations in port, a subsidiary of Rosmorport FSUE, Sea Port Authority and a number of services (immigration, customs and sanitary-veterinary. Institutional and management structure of some Russian Arctic sea ports is significantly different from the typical one resulting in management problems for these socially significant objects of the Russian Arctic. A plan is proposed to improve the organizational and administrative structure of these ports based on the use of domestic and international experience in port infrastructure management including effective cooperation between the state and the private business.

  5. PAS3, a Saccharomyces cerevisiae Gene Encoding a Peroxisomal Integral Membrane Protein Essential for Peroxisome Biogenesis

    NARCIS (Netherlands)

    Höhfeld, Jörg; Veenhuis, Marten; Kunau, Wolf-H.

    Saccharomyces cerevisiae pas3-mutants are described which conform the pas-phenotype recently reported for the peroxisomal assembly mutants pas1-1 and pas2 (Erdmann, R., M. Veenhuis, D. Mertens, and W.-H Kunau. 1989. Proc. Natl. Acad. Sci. USA. 86:5419-5423). The isolation of pas3-mutants enabled us

  6. Successful oral desensitization to i.v. para-aminosalicylic acid (PAS) using encapsulated PAS dry substance.

    Science.gov (United States)

    Vesenbeckh, S M; Becker, J; Huhnt, C; Karras, B; Bauer, T T; Mauch, H; Rüssmann, H; Schönfeld, N

    2012-04-01

    para-Aminosalicylic acid (PAS) is commonly used in the treatment of drug-resistant tuberculosis, including multidrug-resistant tuberculosis. Since its first use in the 1940s, hypersensitivity reactions frequently limit its use in clinical practice. Cases of successful desensitization against PAS using orally administered ascending doses are described in the literature. A 25-year-old patient with severe pulmonary multidrug-resistant tuberculosis developed drug fever with rash, acral cyanosis, and shivering immediately after the intravenous application of PAS. Hard gelatine capsules containing PAS dry substance were prepared in order to desensitize this patient. Encapsulated PAS was applied orally in rising doses starting with 10 mg/day and doubling the dose every 2 days until the half-maximal dose of 5,120 mg was reached. Desensitization covers a period of 21 days. Subsequent intravenous application of PAS at the full dose was well tolerated. In a 12-month follow-up period, no more allergic reactions appeared. PAS dry substance encapsulated in hard gelatine capsules and administered orally in rising concentrations may be useful to archive a successful desensitization for subsequent intravenous applications.

  7. Histopathological examination of nail clippings using PAS staining (HPE-PAS): gold standard in diagnosis of Onychomycosis.

    Science.gov (United States)

    Jeelani, Shazia; Ahmed, Qazi Masood; Lanker, Audil Mohmad; Hassan, Iffat; Jeelani, Nasir; Fazili, Tawheeda

    2015-01-01

    Onychomycosis is fungal infection of one or more of the nail units. However, because fungi cause only about half of all nail dystrophies, the use of appropriate diagnostic techniques is important to ensure correct diagnosis and treatment. Aim of the present study was to compare direct microscopy, culture and HPE-PAS for diagnosis of onychomycosis by evaluating their sensitivity and various other relevant statistical parameters. A prospective, hospital-based, cross-sectional study was conducted on 216 patients with a high degree of clinical suspicion of onychomycosis. Nail specimens were evaluated using three diagnostic methods, i.e. direct microscopy using 20% Potassium hydroxide (KOH) & 40% Di-methyl-suphoxide (DMSO), culture and histopathological examination using PAS stain (HPE-PAS). Of 216 patients direct microscopy was positive in 138 (63.9%), culture in 147 (68%) and HPE-PAS in 164 patients (76%). One hundred and seventy-nine patients fitted into the criteria set for confirmed diagnosis of onychomycosis. Using this as a denominator; direct microscopy, culture and HPE-PAS had sensitivities of 77.1%, 70% and 91.6% respectively. Also, HPE-PAS showed the highest sensitivity of 94.7% in 19 cases with prediagnostic antimycotic treatment compared to direct microscopy (42.1%) or culture (57.9%). HPE-PAS shows high sensitivity for diagnosis of onychomycosis and can be considered as a gold standard in the diagnosis of onychomycosis. © 2014 Blackwell Verlag GmbH.

  8. The role of Atg29 phosphorylation in PAS assembly.

    Science.gov (United States)

    Mao, Kai; Chew, Leon H; Yip, Calvin K; Klionsky, Daniel J

    2013-12-01

    Macroautophagy (hereafter autophagy) initiates at the phagophore assembly site (PAS), where most of the AuTophaGy-related (Atg) proteins are at least transiently localized. As the first protein complex targeted to the PAS, the Atg17-Atg31-Atg29 complex serves as the scaffold for other Atg proteins and plays a critical role for the organization of the PAS, and in autophagy initiation. We recently showed that this complex is constitutively formed and activated by the phosphorylation of Atg29 when autophagy is induced. Phosphorylation of Atg29 is required for its interaction with Atg11, another scaffold protein, and its function for promoting the proper assembly of the PAS. Single-particle electron microscopy analysis of the Atg17-Atg31-Atg29 complex reveals an elongated structure with Atg29 located at the opposing ends. This structural arrangement allows Atg29 to interact with Atg11, and is critical in the organization of the intact Atg1 complex.

  9. Complication-related removal of totally implantable venous access port systems: Does the interval between placement and first use and the neutropenia-inducing potential of chemotherapy regimens influence their incidence? A four-year prospective study of 4045 patients.

    Science.gov (United States)

    Kakkos, A; Bresson, L; Hudry, D; Cousin, S; Lervat, C; Bogart, E; Meurant, J P; El Bedoui, S; Decanter, G; Hannebicque, K; Regis, C; Hamdani, A; Penel, N; Tresch-Bruneel, E; Narducci, F

    2017-04-01

    Totally implantable venous access port systems are widely used in oncology, with frequent complications that sometimes necessitate device removal. The aim of this study is to investigate the impact of the time interval between port placement and initiation of chemotherapy and the neutropenia-inducing potential of the chemotherapy administered upon complication-related port removal. Between January 2010 and December 2013, 4045 consecutive patients were included in this observational, single-center prospective study. The chemotherapy regimens were classified as having a low (20%) risk for inducing neutropenia. The overall removal rate due to complications was 7.2%. Among them, port-related infection (2.5%) and port expulsion (1%) were the most frequent. The interval between port insertion and its first use was shown to be a predictive factor for complication-related removal rates. A cut-off of 6 days was statistically significant (p = 0.008), as the removal rate for complications was 9.4% when this interval was 0-5 days and 5.7% when it was ≥6 days. Another factor associated with port complication rate was the neutropenia-inducing potential of the chemotherapy regimens used, with removal for complications involved in 5.5% of low-risk regimens versus 9.4% for the intermediate- and high-risk regimens (p = 0.003). An interval of 6 days between placement and first use of the port reduces the removal rate from complications. The intermediate- and high-risk for neutropenia chemotherapy regimens are related to higher port removal rates from complications than low-risk regimens. Copyright © 2016 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

  10. Structural characterization of mammalian bHLH-PAS transcription factors.

    Science.gov (United States)

    Wu, Dalei; Rastinejad, Fraydoon

    2017-04-01

    The mammalian basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) transcription factors share common architectural features that include a bHLH DNA-binding domain and tandemly positioned PAS domains. The sixteen members of this family include the hypoxia-inducible factors (HIF-1α and HIF-2α), ARNT (also known as HIF-1β), CLOCK and BMAL1. Most bHLH-PAS proteins have been genetically linked to variety of diseases in humans, including cancers, metabolic syndromes and psychiatric conditions. To function as transcription factors, the bHLH-PAS proteins must form heterodimeric complexes. Recent crystallographic studies of HIF-α-ARNT and CLOCK-BMAL1 complexes have unveiled the organization of their multi-domain bHLH-PAS-A-PAS-B segments, revealing how these architectures can give rise to unique patterns of heterodimerization. As our structural understanding becomes better integrated with ligand-discovery and target gene identification, a more comprehensive picture of their architectural and functional properties will emerge. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Port Stakeholder Summit: Advancing More Sustainable Ports (April 2014)

    Science.gov (United States)

    EPA's National Port Stakeholders Summit, Advancing More Sustainable Ports, focused on actions to protect air quality while reducing climate risk and supporting economic growth, making ports more environmentally sustainable.

  12. Analysis, Design, Modeling, and Control of an Interleaved-Boost Full-Bridge Three-Port Converter for Hybrid Renewable Energy Systems

    DEFF Research Database (Denmark)

    Mira Albert, Maria del Carmen; Zhang, Zhe; Knott, Arnold

    2017-01-01

    This paper presents the design, modeling, and control of an isolated dc-dc three-port converter (TPC) based on an interleaved-boost full-bridge converter with pulsewidth modulation (PWM) and phase-shift control for hybrid renewable energy systems. In the proposed topology, the switches are driven...... by phase-shifted PWM signals, where both phase angle and duty cycle are the controlled variables. The power flow between the two inputs is controlled through the duty cycle, whereas the output voltage can be regulated effectively through the phase shift. The primary-side MOSFETs can achieve zero...

  13. Loss Distribution Analysis of a Three-Port Converter for Low-Power Stand-Alone Light-to-Light Systems

    DEFF Research Database (Denmark)

    Mira Albert, Maria del Carmen; Knott, Arnold; Andersen, Michael A. E.

    2016-01-01

    In locations far from the equator achieving high conversion efficiency in low-power solar systems is challenging due to low solar irradiance levels. This paper presents a high efficiency three-port converter (TPC) for light-to-light (LtL) applications where no direct solar conversion is required...... demonstrates high efficiency in both power flow paths. At low irradiation level, the power flow from the photovoltaic panel to the battery shows a peak efficiency of 99.1% at at 1.5 W output power, and the LED driver stage presents a peak efficiency of 97.3% at 3 W output power....

  14. The Flexible Port

    NARCIS (Netherlands)

    Taneja, P.

    2013-01-01

    Ports are beset with many uncertainties about their futures. They are confronted with new demands in terms of functions and scales, new external constraints, and changed expectations. The inability to adequately meet these demands can mean costly adaptations for a port, or loss of cargo and

  15. Tourist Port Havana

    NARCIS (Netherlands)

    Van der Biezen, T.F.; Kuhlman, W.; Schoen, J.J.; Stam, G.N.; Witteman, D.

    2013-01-01

    To achieve economic growth, the intentions of Cuba are to focus on tourism. The current facilities of the Port of Havana are however in a state of heavy decay and the city is not able to receive tourists travelling by yacht or ferry. For this reason the master plan Tourist Port Havana has been

  16. Minimizing Ports During Robotic Partial Nephrectomy

    National Research Council Canada - National Science Library

    Argun, Omer Burak; Mourmouris, Panagiotis; Tufek, Ilter; Obek, Can; Tuna, Mustafa Bilal; Keskin, Selcuk; Kural, Ali Riza

    2016-01-01

    ...) with a 3-arm setup. The AirSeal system (SurgiQuest, Milford, Connecticut, USA) was used as a port allowing simultaneous introduction of 2 instruments for the bedside surgeon, obviating the need for an additional (fourth) robotic arm...

  17. Structural properties of PAS domains from the KCNH potassium channels.

    Science.gov (United States)

    Adaixo, Ricardo; Harley, Carol A; Castro-Rodrigues, Artur F; Morais-Cabral, João H

    2013-01-01

    KCNH channels form an important family of voltage gated potassium channels. These channels include a N-terminal Per-Arnt-Sim (PAS) domain with unknown function. In other proteins PAS domains are implicated in cellular responses to environmental queues through small molecule binding or involvement in signaling cascades. To better understand their role we characterized the structural properties of several channel PAS domains. We determined high resolution structures of PAS domains from the mouse EAG (mEAG), drosophila ELK (dELK) and human ERG (hERG) channels and also of the hERG domain without the first nine amino acids. We analyzed these structures for features connected to ligand binding and signaling in other PAS domains. In particular, we have found cavities in the hERG and mEAG structures that share similarities with the ligand binding sites from other PAS domains. These cavities are lined by polar and apolar chemical groups and display potential flexibility in their volume. We have also found that the hydrophobic patch on the domain β-sheet is a conserved feature and appears to drive the formation of protein-protein contacts. In addition, the structures of the dELK domain and of the truncated hERG domain revealed the presence of N-terminal helices. These helices are equivalent to the helix described in the hERG NMR structures and are known to be important for channel function. Overall, these channel domains retain many of the PAS domain characteristics known to be important for cell signaling.

  18. Port Stakeholder Summit - April 2014

    Science.gov (United States)

    EPA's National Port Stakeholders Summit, Advancing More Sustainable Ports, focused on actions to protect air quality while reducing climate risk and supporting economic growth, making ports more environmentally sustainable.

  19. Port Blair declaration pledged to establish and develop Andaman and Nicobar Ocean Biogeographic Information System - Meeting report

    Digital Repository Service at National Institute of Oceanography (India)

    Chavan, V; Achuthankutty, C.T.; Nazar, A.K.A

    ) stated that the Andaman Sea has p o tential to be listed as a biod i versity hotspot. However, lack of adequate, a p- propriate, authentic and validated data on the biodiversity of the Anda man Sea is major hurdle in asses s ing this region as a... potential hotspot. C. T. Achuthankutty (Regional Centre, NIO, Kochi) gave an elaborate account of the Census of M a- rine Life (CoML), a multi - national d e cadal programme su p ported by Alfred Sloan Foundatio n. CoML ( http://www.coml.org ) is a...

  20. J-PAS: The Javalambre Physics of the Accelerated Universe Astrophysical Survey

    Science.gov (United States)

    Cepa, J.; Benítez, N.; Dupke, R.; Moles, M.; Sodré, L.; Cenarro, A. J.; Marín-Franch, A.; Taylor, K.; Cristóbal, D.; Fernández-Soto, A.; Mendes de Oliveira, C.; Abramo, L. R.; Alcaniz, J. S.; Overzier, R.; Hernández-Monteagudo, A.; Alfaro, E. J.; Kanaan, A.; Carvano, M.; Reis, R. R. R.; J-PAS Team

    2016-10-01

    The Javalambre Physics of the Accelerated Universe Astrophysical Survey (J-PAS) is a narrow band, very wide field Cosmological Survey to be carried out from the Javalambre Observatory in Spain with a purpose-built, dedicated 2.5 m telescope and a 4.7 sq.deg. camera with 1.2 Gpix. Starting in late 2016, J-PAS will observe 8500 sq.deg. of Northern Sky and measure Δz˜0.003(1+z) photo-z for 9× 107 LRG and ELG galaxies plus several million QSOs, sampling an effective volume of ˜ 14 Gpc3 up to z=1.3 and becoming the first radial BAO experiment to reach Stage IV. J-PAS will detect 7× 105 galaxy clusters and groups, setting constraints on Dark Energy which rival those obtained from its BAO measurements. Thanks to the superb characteristics of the site (seeing ˜ 0.7 arcsec), J-PAS is expected to obtain a deep, sub-arcsec image of the Northern sky, which combined with its unique photo-z precision will produce one of the most powerful cosmological lensing surveys before the arrival of Euclid. J-PAS's unprecedented spectral time domain information will enable a self-contained SN survey that, without the need for external spectroscopic follow-up, will detect, classify and measure σz˜ 0.5 redshifts for ˜ 4000 SNeIa and ˜ 900 core-collapse SNe. The key to the J-PAS potential is its innovative approach: a contiguous system of 54 filters with 145 Å width, placed 100 Å apart over a multi-degree FoV is a powerful redshift machine, with the survey speed of a 4000 multiplexing low resolution spectrograph, but many times cheaper and much faster to build. The J-PAS camera is equivalent to a 4.7 sq.deg. IFU and it will produce a time-resolved, 3D image of the Northern Sky with a very wide range of Astrophysical applications in Galaxy Evolution, the nearby Universe and the study of resolved stellar populations.

  1. Inland Ports in the Republic of Croatia: Approvals for Port Activities instead of Concessions

    Directory of Open Access Journals (Sweden)

    Goran Vojković

    2008-11-01

    Full Text Available According to the 1998 Act on Inland Ports, the right to performall port activities within inland ports of the Republic ofCroatia is given on the basis of concession, obtained throughbidding. It has been noticed in practice that modem businessprocesses and traffic flows are more dynamic than before whenclassic concession relations were created. Also, types andamounts of cargo are changing every couple of years, which isfollowed by quick adjustments, instead of working according torigid and long-term defined decisions and concession contracts.Furthermore, the practice has shown for some activitiesthat the number of port providers (such as ship suppliers,port-agency and freight forwarders should not be limited. Thismeans that the system of a limited number of port providers isimportant only for the activities that require location within aport, as the port area is physically limited. Therefore, the newAct on Navigation and Inland Ports from 2007, whose framehas been completed by sub-law acts during 2008, has replacedthe complex concession system for performing activities in inlandports by a more liberal approval system. On the basis ofthese, higher dynamics of work of port providers is enabled aswell as easier adjustment to market conditions. Furthermore,the main limitation factor that determines the number of portusers becomes the available physical space within a port, whichprovides undisturbed competition, along with larger offer ofport services that do not require that space. It is also importantto point out that the new Act specifically includes distributionand cargo logistics, also processing and improvement of goodsas well as industrial activities including production that enablecomplete economic utilization of port capacities into the existingport activities, thus significantly changing the role of the portitself as a logistic centre.

  2. ProPAS: standalone software to analyze protein properties.

    Science.gov (United States)

    Wu, Songfeng; Zhu, Yunping

    2012-01-01

    Physicochemical properties of proteins/peptides are often used to separate proteins/peptides from complex biological samples in proteomics research, which is necessary for the further proteins/peptides identification. So, the analyses of these properties are very important for the design of proteomic experiments and the further analyses of identified results. Current available web-based tools are difficult to analyze large-scale datasets. Here we provide a standalone software ProPAS (Protein Properties Analyses Software) to calculate these properties in local computers. ProPAS could be used to calculate several physicochemical parameters of proteins/peptides, including the isoelectric point (pI), hydrophobicity (Hy) and mass weight (MW). Additionally, ProPAS provides the statistic results to get the number distribution along the parameter values. The results could be copied to other software such as Excel to get the distribution chart. The amino acid composition of all the input proteins/peptides could also be calculated from all input sequences. Detail description, updates and download link for ProPAS could be found at the website of http://bioinfo.hupo.org.cn/tools/ProPAS/propas.htm.

  3. PAS or plasma for storage of platelets? A concise review.

    Science.gov (United States)

    van der Meer, P F

    2016-10-01

    Platelet additive solutions (PASs) are becoming increasingly popular for storage of platelets, and PAS is steadily replacing plasma as the storage medium of platelets. PASs are electrolyte solutions intended for storage of platelets, and they are used to modulate the quality of the platelets by adding specific ingredients. All currently available PASs contain acetate. Acetate reduces the amount of glucose that is oxidised into lactic acid and thereby prevents the lowering of pH, which decreases platelet quality. Furthermore, the oxidation of acetate leads to the production of bicarbonate, which serves as buffer. The presence of potassium and magnesium in PAS prevents the lowering of pH and reduces the degree of spontaneous activation of the platelets during storage. In the hospital, platelets stored in PAS result in about half of the number of allergic transfusion reactions as compared with platelets in plasma. Recovery and survival after transfusion, as well as corrected count increments, are at least as good for platelets in PAS as for plasma, and recent data suggest they may even be better. Therefore, with the current generation of PASs, PAS should be preferred over the use of plasma for the storage of platelet concentrates. © 2016 British Blood Transfusion Society.

  4. 78 FR 41190 - Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater Port

    Science.gov (United States)

    2013-07-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Maritime Administration Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater Port AGENCY: Maritime Administration, Department of Transportation. ACTION: Notice of intent; notice of...

  5. 78 FR 42588 - Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater Port

    Science.gov (United States)

    2013-07-16

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF TRANSPORTATION Maritime Administration Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater Port AGENCY: Maritime Administration, Department of Transportation. ACTION: Notice of intent...

  6. The effect of intraumbilical fetal nutrition via a subcutaneously implanted port system on amino acid concentration by severe IUGR human fetuses.

    Science.gov (United States)

    Tchirikov, Michael; Zhumadilov, Zhaxybay Sh; Bapayeva, Gauri; Bergner, Michael; Entezami, Michael

    2017-02-01

    To determine if intrauterine intraumbilical supplementation with amino acids (AA) and glucose can improve neonatal outcome of severe growth restricted human fetuses (IUGR). Prospective pilot study of intrauterine treatment of severe IUGR fetuses [n=14, 27 weeks of gestation (range 23-31)] with cerebroplacental ratio IUGR fetuses in both groups. Long-term supplementation with a commercial AA formula led to a slight, but not significant, reduction of histidine, threonine, lysine, arginine, asparagine and glutamine. However, the concentration of tryptophan and glutamic acid slightly increased. HBO can be combined with AA supplementation via a port system. In one case, the port system was also successfully used for fetal blood transfusion. Intravascular treatment of IUGR with fetal nutrition can prolong pregnancy with severe placental insufficiency and brain sparing for many weeks. However, rather than normalizing AA concentrations, an enhanced AA imbalance was observed in IUGR fetuses following supplementation. These deviations in AA concentrations prevent the recommendation for use of commercial AA solutions for prenatal treatment of extreme preterm IUGR fetuses.

  7. Hydrodynamic Conditions and Sediment Movement at Port of Port Orford

    Science.gov (United States)

    2015-05-15

    the Coastal Modeling System (CMS) (Sanchez et al. 2011; Lin et al. 2011) and the Particle Tracking Model ( PTM ) (MacDonald et al. 2006). The CMS and... PTM simulations by the CHL and NWP are conducted under various hydrodynamic and wave conditions, and different configurations of the breakwater...navigation channel. 122 18/03/2015 14 pp 3 Method CMS and PTM The flow and wave modeling for Port Orford is conducted using the CMS. The CMS is an

  8. The Windows serial port programming handbook

    CERN Document Server

    Bai, Ying

    2004-01-01

    The fundamentals of serial port communications. Serial port programming in ANSI C and Assembly languages for MS-DOS. Serial ports interface developed in VC++ 6.0. Serial port programming in Visual Basic. Serial port programming in LabVIEW. Serial port programming in MATLAB. Serial port programming in Smalltalk. Serial port programming in Java.

  9. Impact of Port Investment on Efficiency and Capacity to Attract Traffic in Spain: Bilbao versus Valencia

    OpenAIRE

    Lorena Garcia-Alonso; Monica Martin-Bofarull

    2007-01-01

    The growth in intermodal transport has led to an increase in competition between ports. Other factors, such as the globalisation of the economy, European Union interest in integrating the port system into the Transeuropean Transport Network and the reform of the Spanish port system, have encouraged the Spanish Port Authorities to develop competitive strategies to extend their hinterlands. These strategies have often focused on improving port infrastructure in order to improve the efficiency o...

  10. La question pas si bête. Pourquoi les enfants n'aiment pas les légumes ?

    OpenAIRE

    2017-01-01

    Un gratin de salsifis, des endives rôties ou de bons épinards… Beaucoup de plats à base de légumes n’enchantent pas nos chères petites têtes blondes. Caprice ou réflexe ? Pourquoi les enfants rechignent-ils tant à manger des légumes ? Choux de Bruxelles, salsifis, endives… Faire manger des légumes aux enfants, c’est parfois compliqué. Pourtant, si les enfants ne sont pas fans des légumes du marché, ce n’est pas (seulement) pour faire tourner leurs parents en bourrique. Il s’agit même d’un...

  11. Oluvil Port Development Project

    DEFF Research Database (Denmark)

    Frigaard, Peter; Margheritini, Lucia

    Oluvil Port Development Project is the first development of a large port infrastructure in the entire eastern coastline of Sri Lanka. The project is supported by the Danish Foreign Ministry. Feasibility studies and detailed design studies were carried out by Lanka Hydraulic Institute Ltd during...... the years 1995 to 2003. The design was reviewed by COWI a/s. Construction of the port was started in 2008. MT Højgaard a/s acted as contractor. The outer breakwaters were constructed as first part of the project. During and after completion of the breakwaters a serious beach erosion and sand accumulation...... has been observed. Severe erosion is seen north of the harbour and some accumulation of sand is seen south of the harbour. On a sandy coastline like the one in Oluvil such erosion problems as observed are very typical. The report: Oluvil Port Development Project: Studies on Beach Erosion written...

  12. Current status of robotic single-port colonic surgery.

    Science.gov (United States)

    Bae, Sung Uk; Jeong, Woon Kyung; Baek, Seong Kyu

    2017-03-01

    The present paper reviews evidence and examines updates in single-port robotic surgery for colonic diseases reported in contemporary studies. A comprehensive online systematic search of PubMed databases was carried out in June 2015, identifying studies conducted on robotic single-port colectomy from 2008 to 2015. The advantages and disadvantages of several available port-access systems, techniques for configuring robotic arms, and robotic surgical platforms, were presented. Current studies show that single-port robotic colectomy is a safe and feasible procedure despite the lack of supporting evidence. Although significant advancements in the development and modification of single-access ports, configuration of robotic arms, and robotic surgical platforms have been achieved in the field of single-port robotic surgery for colonic disease, significant improvements to surgical platforms for single-port robotic surgery are needed. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  13. Neutronics analysis for integration of ITER diagnostics port EP10

    Energy Technology Data Exchange (ETDEWEB)

    Colling, Bethany, E-mail: bethany.colling@ccfe.ac.uk [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Department of Engineering, Lancaster University, Lancashire LA1 4YR (United Kingdom); Eade, Tim [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Joyce, Malcolm J. [Department of Engineering, Lancaster University, Lancashire LA1 4YR (United Kingdom); Pampin, Raul; Seyvet, Fabien [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Turner, Andrew [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Udintsev, Victor [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France)

    2016-11-01

    Shutdown dose rate calculations have been performed on an integrated ITER C-lite neutronics model with equatorial port 10. A ‘fully shielded’ configuration, optimised for a given set of diagnostic designs (i.e. shielding in all available space within the port plug drawers), results in a shutdown dose rate in the port interspace, from the activation of materials comprising equatorial port 10, in excess of 2000 μSv/h. Achieving dose rates of 100 μSv/h or less, as required in areas where hands-on maintenance can be performed, in the port interspace region will be challenging. A combination of methods will need to be implemented, such as reducing mass and/or the use of reduced activation steel in the port interspace, optimisation of the diagnostic designs and shielding of the port interspace floor. Further analysis is required to test these options and the ongoing design optimisation of the EP10 diagnostic systems.

  14. Single port access adrenalectomy.

    Science.gov (United States)

    Castellucci, Sean A; Curcillo, Paul G; Ginsberg, Phillip C; Saba, Salim C; Jaffe, Jamison S; Harmon, Justin D

    2008-08-01

    To report the first single port access (SPA) adrenalectomy to minimize patient discomfort through a less invasive procedure. We performed the first SPA in a 63-year-old, otherwise healthy Caucasian female who had a 4.5-cm left adrenal mass that was incidentally discovered on computed tomography scan of the abdomen and pelvis. Through a 2-cm single longitudinal supraumbilical incision extended down to the abdominal fascia, three 5-mm ports were placed through separate facial entry points, to make a triangular port arrangement. The adrenal vein was identified and ligated using hemoclips. The remainder of the dissection was done using hemocoagulation. The adrenal gland was extracted via an EndoCatch bag device by removing one 5-mm port and upsizing to a 12-mm port. We report on the first SPA adrenalectomy. Although this technology is still in its infancy, the use of a single port for surgery provides a means to provide a potentially better patient outcome with a less invasive procedure.

  15. Ceci n'est pas une pipe

    Directory of Open Access Journals (Sweden)

    Luis Rojo de Castro

    2012-12-01

    reflection on the processes of decontextualization of objects pertaining to modern culture. It starts its journey with images of the Ethnographic Museum at the Trocadero in Paris, founded in 1878 and transformed into the  Museum of Man in 1930. The thesis of the article is about  uncovering the cultural and productive mechanisms of  decontextualization and re‐contextualization characteristic of the 20th century, based on the original images of the Ethnographic Museum and of artists such as Braque, Breton or Picasso, along with images of urban spaces from that particular period of time  (galleries and arcades.
    All these photographs have something in common: they offer us interior and interiorized spaces in which objects are grouped together and float with a surprising degree of autonomy. They  are fragments from other cultures, other systems, that are now “collected” together next to other fragments. Alien to their  original function, decontextualized from their original  environment, they now share a common space, forced to  participate in a system of relations that turns them into objects, makes them opaque, and separates them from their origin and  “nature.” From an active role (cultural, semiotic, social, etc., they have gone to play a passive role. They have lost the meaning that belonged to them, and now they wait for the  observer to endow them with the new fruit of the relationship created between them, which will take them to a new place.
    This technique of 'strangeness and fragmentation' causes the dismemberment underlying "system objects" of our own time, in which coherence of relations systems (specific to each place has been replaced by the exuberance of simulating production and  experience.

    Key words

    decontextualization, images, mechanisms, collection, place

  16. Ceux-ci ne sont pas : [luuletused] / Kalju Kruusa

    Index Scriptorium Estoniae

    Kruusa, Kalju, pseud., 1973-

    2003-01-01

    Sisu: Ceux-ci ne sont pas ; Köögivahet ; "Taara..." ; "Pakane pistab pisikesi ..." ; "Meri on kaet mattklaasiga ; Pydemise päivil ; "Toas muusika mängib ..." ; "Jäin juustu imetlema ; "Mu elu on mustikas ..." ; Hingepidetus ; ŁNo me gusta la cocina

  17. Use of Subdural Evacuating Port System Following Open Craniotomy with Excision of Native Dura and Membranes for Management of Chronic Subdural Hematoma.

    Science.gov (United States)

    Cage, Tene; Bach, Ashley; McDermott, Michael W

    2017-04-26

    An 86-year-old woman was admitted to the intensive care unit with a chronic subdural hematoma (CSDH) and rapid onset of worsening neurological symptoms. She was taken to the operating room for a mini-craniotomy for evacuation of the CSDH including excision of the dura and CSDH membrane. Postoperatively, a subdural evacuation port system (SEPS) was integrated into the craniotomy site and left in place rather than a traditional subdural catheter drain to evacuate the subdural space postoperatively. The patient had a good recovery and improvement of symptoms after evacuation and remained clinically well after the SEPS was removed. We offer the technique of dura and CSDH membrane excision plus SEPS drain as an effective postoperative alternative to the standard craniotomy leaving the native dura intact with traditional subdural drain that overlies the cortical surface of the brain in treating patients with CSDH.

  18. J-tipped guidewire as a target for puncture of the subclavian artery in the placement of a reservoir port and catheter system

    Energy Technology Data Exchange (ETDEWEB)

    Hama, Yukihiro; Kusano, Shoichi [Department of Radiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-0042, Saitama (Japan); Makita, Kohzoh [Department of Radiology, Social Insurance Chuo General Hospital, Tokyo (Japan)

    2004-05-01

    The aim of this study was to verify the feasibility of using a J-tipped guidewire as a target for puncture of the subclavian artery in the placement of a reservoir port and catheter system (RPCS). Twenty-five patients with various hepatic malignancies underwent percutaneous implantation of an RPCS through the left subclavian artery for regional chemotherapy. To successfully puncture the left subclavian artery, a J-tipped guidewire was used as a target with fluoroscopic guidance. Technical success and complication rates, and numbers of puncture failures, were retrospectively analyzed. Implantation of the RPCS was successful in all patients. Eight (32%) patients had minor complications and no patient had major complications. The number of puncture failures per patient was 0 to 1 (mean=0.32). The J-tipped guidewire is a safe and appropriate target for puncture of the subclavian artery in the placement of an RPCS. (orig.)

  19. Evaluating sustainable logistics for Local Food Systems and using colaboration as a tool for rationnalization in the retail-wholesale sector: A case study in the Nord-Pas de Calais region, France

    OpenAIRE

    Duault, Agathe

    2015-01-01

    Localizing the organic food system is a key element for sustaining the development of organic agriculture globally. Local Food Systems (LFS) are often attributed to having advantages but their economic, ecological and social performances are questioned mainly due to low logistics rationalization. The organic retail-wholesale sector is particularly affected by logistics problems (low-volume delivery, and numerous delivery points). This study evaluates collaboration as a tool for logistic ratio...

  20. The PAS fold: A redefinition of the PAS domain based upon structural prediction. A large-scale homology modelling study

    NARCIS (Netherlands)

    Hefti, M.H.; Francoijs, C.J.J.; Vries, de S.C.; Dixon, R.; Vervoort, J.J.M.

    2004-01-01

    In the postgenomic era it is essential that protein sequences are annotated correctly in order to help in the assignment of their putative functions. Over 1300 proteins in current protein sequence databases are predicted to contain a PAS domain based upon amino acid sequence alignments. One of the

  1. Modified PAS stain: A new diagnostic method for onychomycosis.

    Science.gov (United States)

    Hajar, Tamar; Fernández-Martínez, Ramon; Moreno-Coutiño, Gabriela; Vásquez Del Mercado, Elsa; Arenas, Roberto

    2016-01-01

    Onychomycosis is the most common nail disease and represents around 50% of nail disorders. Accurate diagnosis with adequate evidence is ideal before starting any treatment. Current diagnostic methods offer low specificity and sensitivity. To create a new method for the diagnosis of onychomycosis, and to compare its sensitivity and specificity with the existing methods. One hundred and ninety-two samples with clinical suspicion of onychomycosis were included and underwent modified PAS stain (M-PAS), KOH/chlorazol black (KOH/CB) and culture testing. Sensitivity, specificity, positive and negative predictive values were calculated. In 152 out of 192 samples (79.2%) fungi structures were found in at least one of the three tests performed, and the patients were diagnosed with onychomycosis; 40 samples out of 192 (20.8%) were negative. Using M-PAS, filaments and/or spores were seen in 143 samples from the 152 positive (94%); 39 of them were negative to KOH/CB and positive to M-PAS (25.6%). With KOH/CB, filaments and/or spores were seen in 113 cases from the 152 positive samples (73.8% of the onychomycosis cases). Thirty-five cultures were positive, of which 77% were identified as Trichophyton rubrum; 117 onychomycosis cases were diagnosed despite the negative culture (76.9%). M-PAS showed 92.5% sensitivity and 55.55% specificity, a 67.5% positive predictive value and a 81.6% negative productive value. This procedure, a combination of the existing methods to diagnose onychomycosis, KOH/CB together with a nail clipping biopsy, proved to have high sensitivity, as well as being rapid, easy, inexpensive and readily available in most hospital settings. M-PAS allowed us to diagnose 39 cases (25.6% of the cases of onychomycosis) that were false negative using only KOH/CB and culture. Copyright © 2014 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

  2. Classification and prediction of port variables

    Energy Technology Data Exchange (ETDEWEB)

    Molina Serrano, B.

    2016-07-01

    Many variables are included in planning and management of port terminals. They can beeconomic, social, environmental and institutional. Agent needs to know relationshipbetween these variables to modify planning conditions. Use of Bayesian Networks allowsfor classifying, predicting and diagnosing these variables. Bayesian Networks allow forestimating subsequent probability of unknown variables, basing on know variables.In planning level, it means that it is not necessary to know all variables because theirrelationships are known. Agent can know interesting information about how port variablesare connected. It can be interpreted as cause-effect relationship. Bayesian Networks can beused to make optimal decisions by introduction of possible actions and utility of theirresults.In proposed methodology, a data base has been generated with more than 40 port variables.They have been classified in economic, social, environmental and institutional variables, inthe same way that smart port studies in Spanish Port System make. From this data base, anetwork has been generated using a non-cyclic conducted grafo which allows for knowingport variable relationships - parents-children relationships-. Obtained network exhibits thateconomic variables are – in cause-effect terms- cause of rest of variable typologies.Economic variables represent parent role in the most of cases. Moreover, whenenvironmental variables are known, obtained network allows for estimating subsequentprobability of social variables.It has been concluded that Bayesian Networks allow for modeling uncertainty in aprobabilistic way, even when number of variables is high as occurs in planning andmanagement of port terminals. (Author)

  3. Marseille : une relecture de l’interface ville-port au prisme de l’habiter 

    OpenAIRE

    Bertoncello, Brigitte; Hagel, Zoé

    2017-01-01

    Dans la littérature sur le dialogue ville-port, l’habiter n’apparaît pas comme une préoccupation centrale. À Marseille, dynamique portuaire et renouvellement urbain (dont le projet Euroméditerranée) dessinent, le long des bassins Est du Grand port maritime, une interface hétérogène. Partant du point de vue des associations, nous avons souhaité interroger comment côté ville se vit la présence d’un port. Les enquêtes conduites (observations, entretiens) croisées avec l’analyse de documents prod...

  4. A Compact Novel Three-Port Integrated Wide and Narrow Band Antennas System for Cognitive Radio Applications

    Directory of Open Access Journals (Sweden)

    N. Anvesh Kumar

    2016-01-01

    Full Text Available The design of a three-port radiating structure, integrating wide and narrow band antennas for cognitive radio applications, is presented. It consists of a UWB antenna for spectrum sensing and two narrow band antennas for wireless communication integrated on the same substrate. The UWB antenna covers the complete UWB spectrum (3.1 GHz to 10.6 GHz approved by FCC. In the two narrow band antennas, each antenna presents dual bands. In particular, the first narrowband antenna resonates at 6.5 GHz, covering the frequency band between 6.36 GHz and 6.63 GHz, and at 9 GHz, covering the frequency band between 8.78 GHz and 9.23 GHz, presenting minimum return loss values of 28.3 dB at 6.5 GHz and 20.5 dB at 9 GHz, respectively. Similarly, the second one resonates at 7.5 GHz, covering the frequency band between 7.33 GHz and 7.7 GHz, and at 9.5 GHz, covering the frequency band between 9.23 GHz and 9.82 GHz, presenting minimum return loss values of 19.6 dB at 7.5 GHz and 28.8 dB at 9.5 GHz, respectively. Isolation among the three antennas is less than −20 dB over the UWB frequency spectrum. These antennas are realized on a FR4 substrate of dimensions 30 mm × 30 mm × 1.6 mm. Experimental results show a good agreement between the simulated and measured results.

  5. Slewing Port Jib Cranes

    Directory of Open Access Journals (Sweden)

    Boris Visočnik

    2002-09-01

    Full Text Available The paper presents slewing port cra11es with a luffing jib.The advantages of slewing port jib cranes are high lifting capacities,high speeds of re-loading and excellent mobility since theyare capable of load lifting, travelling, luffing and slewing. Thepaper gives a detailed description of their characteristics suchas the highest reached load-canying capacities, speeds of motionand accelerations. It also presents the crane assembly,driving mechanisms, loads and load cases, transport by shipsand testing of lifting capacity. As a practical example the paperpresents the slewing port jib crane with the capacity of25!15!5 tat a 27/37/40 m radius made by the Slovenian companyMetalna Maribor for the shipyard 3. Maj, Rijeka, Croatia.

  6. Charging for port reception facilities in North Sea ports: putting theory into practice.

    Science.gov (United States)

    Carpenter, A; Macgill, S

    2001-04-01

    The aim of this paper is to evaluate the charging systems for the use of port reception facilities for waste oil, and to examine the potential impact of the charging elements of the new (late 2000) EU Directive on port reception facilities for ship-generated waste and cargo residues. Experience to date with alternative models for charging is considered. Conclusions are drawn about the effectiveness of the EU Directive as a means of controlling pollution in the North Sea and producing a 'level playing field' between ports.

  7. Hans sidste ønske var et pas

    DEFF Research Database (Denmark)

    Sodemann, Morten

    2014-01-01

    Selv med svære sygdomme, bunker af lægeerklæringer, ekspertvurderinger og værdig stædighed opnår flygtninge ikke at få et dansk pas. Justitsministeriet bagatelliserer lægernes oplysninger og holder ansøgere hen med ligegyldigheder, indtil de dør åndeligt eller fysisk......Selv med svære sygdomme, bunker af lægeerklæringer, ekspertvurderinger og værdig stædighed opnår flygtninge ikke at få et dansk pas. Justitsministeriet bagatelliserer lægernes oplysninger og holder ansøgere hen med ligegyldigheder, indtil de dør åndeligt eller fysisk...

  8. Hans sidste ønske var et dansk pas

    DEFF Research Database (Denmark)

    Sodemann, Morten

    2014-01-01

    Selv med svære sygdomme, bunker af lægeerklæringer, ekspertvurderinger og værdig stædighed opnår flygtninge ikke at få et dansk pas. Justitsministeriet bagatelliserer lægernes oplysninger og holder ansøgere hen med ligegyldigheder, indtil de dør åndeligt eller fysisk......Selv med svære sygdomme, bunker af lægeerklæringer, ekspertvurderinger og værdig stædighed opnår flygtninge ikke at få et dansk pas. Justitsministeriet bagatelliserer lægernes oplysninger og holder ansøgere hen med ligegyldigheder, indtil de dør åndeligt eller fysisk...

  9. Port investment : Towards an integrated planning of port capacity

    NARCIS (Netherlands)

    Dekker, S.

    2005-01-01

    This study supports strategic planning of a node in a transportation network. It contributes to this by the development of a methodology for planning of port capacity in which port-commercial and public interests are integrated. The focus is the reaction of a single port on a change in the

  10. The Spatio-Temporal Distribution and Development Modes of Border Ports in China

    Directory of Open Access Journals (Sweden)

    Jiaoe Wang

    2014-10-01

    Full Text Available Border ports play a substantial role in socio-economic exchanges, which reflect the diplomatic relations between neighboring countries. This paper maps and analyzes the evolution process of border ports in China since the 1930s, in terms of the spatial distribution, transport modes, cargo and flows of people. Four development modes of border ports and cities are summarized based on the functions and development level of border ports and their proximity to urban core areas. The four modes include: (1 Port-Port mode; (2 City-Port-Port-City mode; (3 City (Port-Port-City mode; (4 City (Port-City (Port mode, which also reflect the spatio-temporal evolution process of certain border ports and cities. The results show that the development of border ports is closely related to the bilateral relations with neighboring countries and their complementarities of natural resources and economic development, national foreign policies, as well as the physical, historical and cultural context. The findings of this study are helpful to promote the sustainable development of the border port system which is crucial for win-win reciprocity between China and its neighboring countries.

  11. The_port_2017

    CERN Multimedia

    2017-01-01

    Organised by THE Port Association, hosted by CERN IdeaSquare and with partners from other non-governmental organisations, a three-day problem solving workshop hackathon devoted to humanitarian, social and public interest challenges. Interdisciplinary teams of hand selected participants working together in the fields of: communication – transport – health – science – education – work – culture – data

  12. Strategic port development

    DEFF Research Database (Denmark)

    Olesen, Peter Bjerg; Dukovska-Popovska, Iskra; Steger-Jensen, Kenn

    2012-01-01

    This paper proposes a framework for strategic development of a port’s collaboration with its hinterland. The framework is based on literature relevant to port development and undertakes market perspective by considering import/export data relevant for the region of interest. The series of steps...

  13. Essays on Dry Ports

    NARCIS (Netherlands)

    G.G. Chandrakant (Gujar)

    2011-01-01

    textabstractDue to several reasons, currently the global supply chains are getting stretched further away into the hinterlands from the gateway seaports. This single fact enhances the importance of dry ports. It would not be against logic, to state that in coming times, as a result of ever-growing

  14. ROCKET PORT CLOSURE

    Science.gov (United States)

    Mattingly, J.T.

    1963-02-12

    This invention provides a simple pressure-actuated closure whereby windowless observation ports are opened to the atmosphere at preselected altitudes. The closure comprises a disk which seals a windowless observation port in rocket hull. An evacuated instrument compartment is affixed to the rocket hull adjacent the inner surface of the disk, while the outer disk surface is exposed to the atmosphere through which the rocket is traveling. The pressure differential between the evacuated instrument compartment and the relatively high pressure external atmosphere forces the disk against the edge of the observation port, thereby effecting a tight seai. The instrument compartment is evacuated to a pressure equal to the atmospheric pressure existing at the altitude at which it is desiretl that the closure should open. When the rocket reaches this preselected altitude, the inwardly directed atmospheric force on the disk is just equaled by the residual air pressure force within the instrument compartment. Consequently, the closure disk falls away and uncovers the open observation port. The separation of the disk from the rocket hull actuates a switch which energizes the mechanism of a detecting instrument disposed within the instrument compartment. (AE C)

  15. COSIMA-ES-PORT

    DEFF Research Database (Denmark)

    Barfod, Michael Bruhn; Leleur, Steen

    2007-01-01

    -ES-PORT model showed some promising perspectives in the handling of the three pre-feasibility studies. Parameters such as cargo handling and ship related issues could with advantage be implemented in the decision model and forecasted similarly to road infrastructure impacts. Furthermore, the development...

  16. Toxins vapC and pasB from prokaryotic TA modules remain active in mammalian cancer cells.

    Science.gov (United States)

    Wieteska, Łukasz; Skulimowski, Aleksander; Cybula, Magdalena; Szemraj, Janusz

    2014-09-30

    Among the great number of addictive modules which have been discovered, only a few have been characterized. However, research concerning the adoption of toxins from these systems shows their great potential as a tool for molecular biology and medicine. In our study, we tested two different toxins derived from class II addictive modules, pasAB from plasmid pTF-FC2 (Thiobacillus ferrooxidans) and vapBC 2829Rv (Mycobacterium tuberculosis), in terms of their usefulness as growth inhibitors of human cancer cell lines, namely KYSE 30, MCF-7 and HCT 116. Transfection of the pasB and vapC genes into the cells was conducted with the use of two different expression systems. Cellular effects, such as apoptosis, necrosis and changes in the cell cycle, were tested by applying flow cytometry with immunofluorescence staining. Our findings demonstrated that toxins VapC and PasB demonstrate proapoptotic activity in the human cancer cells, regardless of the expression system used. As for the toxin PasB, observed changes were more subtle than for the VapC. The level of expression for both the genes was monitored by QPCR and did not reveal statistically significant differences within the same cell line.

  17. An XML-Based Knowledge Management System of Port Information for U.S. Coast Guard Cutters

    National Research Council Canada - National Science Library

    Stewart, Jeffrey

    2003-01-01

    .... The system uses XML technologies in server/client and stand alone environments. With a web browser, the user views and navigates the system's content from a downloaded file collection or from a centralized data source via a network connection...

  18. 32 CFR 806b.11 - When to give Privacy Act Statements (PAS).

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false When to give Privacy Act Statements (PAS). 806b.11 Section 806b.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE... (PAS). (a) Give a PAS orally or in writing to the subject of the record when you are collecting...

  19. Development of an economic framework to evaluate resilience in recovering from major port disruptions : final report.

    Science.gov (United States)

    2017-02-03

    Ports play a critical role in a nations economic system. The impact of a major port disruption can reverberate across the entire economy through regional and national supply-chains. This study develops an operational framework to evaluate the effe...

  20. 78 FR 37878 - Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater Port

    Science.gov (United States)

    2013-06-24

    ... Maritime Administration Deepwater Port License Application: Liberty Natural Gas LLC, Port Ambrose Deepwater... required by the Act. Summary of the Application Liberty Natural Gas, LLC is proposing to construct, own... different design than the previous deepwater port license application submitted by Liberty Natural Gas, LLC...

  1. Gas Sensing and Signaling in the PAS-Heme Domain of the Pseudomonas aeruginosa Aer2 Receptor.

    Science.gov (United States)

    Garcia, Darysbel; Orillard, Emilie; Johnson, Mark S; Watts, Kylie J

    2017-09-15

    The Aer2 chemoreceptor from Pseudomonas aeruginosa contains a PAS sensing domain that coordinates b-type heme and signals in response to the binding of O2, CO, or NO. PAS-heme structures suggest that Aer2 uniquely coordinates heme via a His residue on a 310 helix (H234 on Eη), stabilizes O2 binding via a Trp residue (W283), and signals via both W283 and an adjacent Leu residue (L264). Ligand binding may displace L264 and reorient W283 for hydrogen bonding to the ligand. Here, we clarified the mechanisms by which Aer2-PAS binds heme, regulates ligand binding, and initiates conformational signaling. H234 coordinated heme, but additional hydrophobic residues in the heme cleft were also critical for stable heme binding. O2 appeared to be the native Aer2 ligand (dissociation constant [Kd ] of 16 μM). With one exception, mutants that bound O2 could signal, whereas many mutants that bound CO could not. W283 stabilized O2 binding but not CO binding, and it was required for signal initiation; W283 mutants that could not stabilize O2 were rapidly oxidized to Fe(III). W283F was the only Trp mutant that bound O2 with wild-type affinity. The size and nature of residue 264 was important for gas binding and signaling: L264W blocked O2 binding, L264A and L264G caused O2-mediated oxidation, and L264K formed a hexacoordinate heme. Our data suggest that when O2 binds to Aer2, L264 moves concomitantly with W283 to initiate the conformational signal. The signal then propagates from the PAS domain to regulate the C-terminal HAMP and kinase control domains, ultimately modulating a cellular response.IMPORTANCEPseudomonas aeruginosa is a ubiquitous environmental bacterium and opportunistic pathogen that infects multiple body sites, including the lungs of cystic fibrosis patients. P. aeruginosa senses and responds to its environment via four chemosensory systems. Three of these systems regulate biofilm formation, twitching motility, and chemotaxis. The role of the fourth system, Che2, is

  2. 33 CFR 149.140 - What communications equipment must be on a deepwater port?

    Science.gov (United States)

    2010-07-01

    ...? (a) Each deepwater port must have the following communications equipment: (1) A system for continuous two-way voice communication among the deepwater port, the tankers, the support vessels, and other vessels operating at the port. The system must be usable and effective in all phases of a transfer and in...

  3. Analysis of battery behavior in small photovoltaic systems; Analise do comportamento da bateria utilizada em sistemas fotovoltaicos de pequeno porte

    Energy Technology Data Exchange (ETDEWEB)

    Fraga, Jose Renato Castro Pompeia; Cagnon, Jose Angelo [Programa de Pos-Graduacao em Agronomia - Energia na Agricultura - FCA/UNESP, Botucatu, SP (Brazil); Dept. de Engenharia Eletrica - FEB/UNESP, Bauru, SP (Brazil)], e-mails: jrfraga@feb.unesp.br, jacagnon@feb.unesp.br

    2011-07-01

    This work aimed to analyze the electric energy storage system generated from a photovoltaic system with lead-acid batteries. The increasing claim for energy in the world in addition to the need of using renewable energy sources in order to preserve the environment makes necessary the development of efficient techniques of power supply and control. Two photovoltaic systems were used in this work, a conventional one with stationary solar panel and another with automatic solar position system. The comparative analysis has allowed assessing the advantages of both systems. The following characteristics were obtained during the development of this work: charge, discharge, battery capacity, operating time rate, auto-discharge reaction (through fluctuation state), among other important information that allows an extended life to the stationary battery studied. The obtained results indicate that the battery connected to the mobile system provides 36% of additional energy compared to the fixed system. When the battery was unable to provide energy to the load, the battery connected to the mobile system consumed about 33% less energy than that one connected to the fixed system (author)

  4. BrainPort(Registered trademark) Technology Tongue Interface Characterization

    Science.gov (United States)

    2010-03-01

    vestibular deficits, the BrainPort vision device, a sensory augmentation device for the blind, and the BrainPort Underwater Sensory Substitution System...address to a register value VC Set voltage to a constant value VR Set voltage to a register value RV Set a voltage register vavlue RA Set an

  5. Simulation model for port shunting yards

    Science.gov (United States)

    Rusca, A.; Popa, M.; Rosca, E.; Rosca, M.; Dragu, V.; Rusca, F.

    2016-08-01

    Sea ports are important nodes in the supply chain, joining two high capacity transport modes: rail and maritime transport. The huge cargo flows transiting port requires high capacity construction and installation such as berths, large capacity cranes, respectively shunting yards. However, the port shunting yards specificity raises several problems such as: limited access since these are terminus stations for rail network, the in-output of large transit flows of cargo relatively to the scarcity of the departure/arrival of a ship, as well as limited land availability for implementing solutions to serve these flows. It is necessary to identify technological solutions that lead to an answer to these problems. The paper proposed a simulation model developed with ARENA computer simulation software suitable for shunting yards which serve sea ports with access to the rail network. Are investigates the principal aspects of shunting yards and adequate measures to increase their transit capacity. The operation capacity for shunting yards sub-system is assessed taking in consideration the required operating standards and the measure of performance (e.g. waiting time for freight wagons, number of railway line in station, storage area, etc.) of the railway station are computed. The conclusion and results, drawn from simulation, help transports and logistics specialists to test the proposals for improving the port management.

  6. Port Security Strategy 2012

    Science.gov (United States)

    2007-06-15

    incidents and events. The cognitive thinking and behavior of humans could be influenced by psychological operation. The emotions, motives, objective...to emulate dolphin sonar and incorporate search strategies that are specifically effective in the noisy near-shore environment. This is to emulate...Animals can be also trained to aid port security on different dimensions. Trained sea lions and dolphins are able to locate underwater divers

  7. Laparoscopic Toupet Fundoplication using an Air Seal Intelligent Flow System and Anchor Port in a 1.8-kg infant: A Technical Report.

    Science.gov (United States)

    Miyano, Go; Morita, Keiichi; Kaneshiro, Masakatsu; Miyake, Hiromu; Nouso, Hiroshi; Yamoto, Masaya; Koyama, Mariko; Nakano, Reiji; Tanaka, Yasuhiko; Fukumoto, Koji; Urushihara, Naoto

    2015-08-01

    We report a case of a 1.8-kg infant who had laparoscopic Toupet fundoplication (LTF) using the AirSeal Intelligent Flow System and Anchor Port (AP). Our case had severe gastroesophageal reflux in association with genetic and cardiac anomalies. Despite the patient being continuously fed, persistent vomiting caused failure to thrive, and LTF was performed at 4 months of age when he weighed 1.8 kg. The AirSeal Intelligent Flow System is a novel laparoscopic CO2 insufflation system that improves the visual field by constantly evacuating smoke and providing a more stable pneumoperitoneum. The AP is a recently developed, stretchable, elastomeric, low-profile cannula. Three 5-mm AP were inserted: one subumbilically for the scope and one in both the right and left upper abdomen for the surgeon. A 5-mm AirSeal trocar was inserted in the left lower abdomen for the assistant. The gastrosplenic ligament was dissected free, and the intra-abdominal esophagus was prepared. A posterior hiatoplasty was performed, followed by the 270° fundoplication. During the fundoplication, the esophagus was fixed to the crus and then the right and left wraps were fixed to the esophagus. Pneumoperitoneum was maintained stably throughout the LTF procedure, with optimal operative field. Total operating time for LTF was 90 min. Body temperature dropped from 37.4°C to 35.7°C during pneumoperitoneum but resolved once pneumoperitoneum was ceased. Postoperative progress was uneventful, and an upper gastrointestinal study on postoperative day 2 showed no residual gastroesophageal reflux. We believe the AirSeal Intelligent Flow System and AP contributed to the successful completion of LTF in a 1.8-kg infant. © 2015 Japan Society for Endoscopic Surgery, Asia Endosurgery Task Force and Wiley Publishing Asia Pty Ltd.

  8. Study on Commercialization of Biogasification Systems in Ishikari Bay New Port Area - Proposal of Estimation Method of Collectable Amount of Food Waste by using Binary Logit Model -

    Science.gov (United States)

    Watanabe, Sho; Furuichi, Toru; Ishii, Kazuei

    This study proposed an estimation method for collectable amount of food waste considering the food waste generator's cooperation ratio ant the amount of food waste generation, and clarified the factors influencing the collectable amount of food waste. In our method, the cooperation ratio was calculated by using the binary logit model which is often used for the traffic multiple choice question. In order to develop a more precise binary logit model, the factors influencing on the cooperation ratio were extracted by a questionnaire survey asking food waste generator's intention, and the preference investigation was then conducted at the second step. As a result, the collectable amount of food waste was estimated to be 72 [t/day] in the Ishikari bay new port area under a condition of current collection system by using our method. In addition, the most critical factor influencing on the collectable amount of food waste was the treatment fee for households, and was the permitted mixture degree of improper materials for retail trade and restaurant businesses

  9. PERFORMANCE ASSESSMENT IN OPERATING DRY PORTS

    Directory of Open Access Journals (Sweden)

    Ciortescu Cezar-Gabriel

    2010-12-01

    Full Text Available In this paper, an approach for recognizing and defining correct and operable performance will be presented with the purpose of evaluating the effectiveness and efficiency of processes in dry ports (inland intermodal hubs. The challenge in evaluating the possible improvements of the underlying processes lies in the special nature and the complex structure of dry ports. It is important to consider that all the processes are highly interconnected and that changes in parameters in one process also have an impact on parameters in other processes. Furthermore, the performance of dry ports, seen as the backbone of the system, has a significant impact on the overall performance of the whole transportation network.

  10. Operational Optimization in Port Container Terminals

    DEFF Research Database (Denmark)

    As a result of the significant increase in worldwide containerized transportation the development of efficient handling systems in marine terminals has become very important for port competitiveness. In order to optimize the productivity the total handling time for containers in the terminal must...... be minimized. An overview of the different operational problems in port container terminals is presented and an aggregated model and solution approach is shown. Next, there will be focused on the yard storage problem and a mathematical formulation and solution proposals will be presented....

  11. Biological control of Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) using Aeromonas phage PAS-1.

    Science.gov (United States)

    Kim, J H; Choresca, C H; Shin, S P; Han, J E; Jun, J W; Park, S C

    2015-02-01

    The potential control efficacy of Aeromonas phage PAS-1 was evaluated against Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) model in this study. The phage was co-cultured with the virulent A. salmonicida subsp. salmonicida strain AS05 that possesses the type III secretion system (TTSS) ascV gene, and efficient bacteriolytic activity was observed against the bacteria. The administration of PAS-1 in rainbow trout demonstrated that the phage was cleared from the fish within 200 h post-administration, and a temporal neutralizing activity against the phage was detected in the sera of phage-administrated fish. The administration of PAS-1 (multiplicity of infection: 10 000) in A. salmonicida subsp. salmonicida infected rainbow trout model showed notable protective effects, with increased survival rates and mean times to death. These results demonstrated that Aeromonas phage PAS-1 could be considered as an alternative biological control agent against A. salmonicida subsp. salmonicida infections in rainbow trout culture. © 2013 Blackwell Verlag GmbH.

  12. Delineating PAS-HAMP interaction surfaces and signalling-associated changes in the aerotaxis receptor Aer.

    Science.gov (United States)

    Garcia, Darysbel; Watts, Kylie J; Johnson, Mark S; Taylor, Barry L

    2016-04-01

    The Escherichia coli aerotaxis receptor, Aer, monitors cellular oxygen and redox potential via FAD bound to a cytosolic PAS domain. Here, we show that Aer-PAS controls aerotaxis through direct, lateral interactions with a HAMP domain. This contrasts with most chemoreceptors where signals propagate along the protein backbone from an N-terminal sensor to HAMP. We mapped the interaction surfaces of the Aer PAS, HAMP and proximal signalling domains in the kinase-off state by probing the solvent accessibility of 129 cysteine substitutions. Inaccessible PAS-HAMP surfaces overlapped with a cluster of PAS kinase-on lesions and with cysteine substitutions that crosslinked the PAS β-scaffold to the HAMP AS-2 helix. A refined Aer PAS-HAMP interaction model is presented. Compared to the kinase-off state, the kinase-on state increased the accessibility of HAMP residues (apparently relaxing PAS-HAMP interactions), but decreased the accessibility of proximal signalling domain residues. These data are consistent with an alternating static-dynamic model in which oxidized Aer-PAS interacts directly with HAMP AS-2, enforcing a static HAMP domain that in turn promotes a dynamic proximal signalling domain, resulting in a kinase-off output. When PAS-FAD is reduced, PAS interaction with HAMP is relaxed and a dynamic HAMP and static proximal signalling domain convey a kinase-on output. © 2015 John Wiley & Sons Ltd.

  13. Influence of PAS domain flanking regions on oligomerisation and redox signalling by NifL.

    Directory of Open Access Journals (Sweden)

    Richard Little

    Full Text Available Per-ARNT-Sim (PAS domains constitute a typically dimeric, conserved α/β tertiary fold of approximately 110 amino acids that perform signalling roles in diverse proteins from all kingdoms of life. The amino terminal PAS1 domain of NifL from Azotobacter vinelandii accommodates a redox-active FAD group; elevation of cytosolic oxygen concentrations result in FAD oxidation and a concomitant conformational re-arrangement that is relayed via a short downstream linker to a second PAS domain, PAS2. At PAS2, the signal is amplified and passed on to effector domains generating the 'on' (inhibitory state of the protein. Although the crystal structure of oxidised PAS1 reveals regions that contribute to the dimerisation interface, 21 amino acids at the extreme N-terminus of NifL, are unresolved. Furthermore, the structure and function of the linker between the two PAS domains has not been determined. In this study we have investigated the importance to signalling of residues extending beyond the core PAS fold. Our results implicate the N-terminus of PAS1 and the helical linker connecting the two PAS domains in redox signal transduction and demonstrate a role for these flanking regions in controlling the oligomerisation state of PAS1 in solution.

  14. PAS-1, a protein affinity purified from Ascaris suum worms, maintains the ability to modulate the immune response to a bystander antigen.

    Science.gov (United States)

    Oshiro, Telma M; Enobe, Cristina S; Araújo, Cláudia A; Macedo, Mahasti S; Macedo-Soares, Maria Fernanda

    2006-04-01

    Helminth infections and parasite components have potent immunomodulatory effects on a host's immune system. In the present study, we investigated the effect of PAS-1, a protein component of Ascaris suum adult worms recognized by a monoclonal antibody (MAIP-1), on humoral and cell-mediated responses to a bystander antigen (ovalbumin [OVA]). MAIP-1 recognized only one of the three polypeptide chains of PAS-1, but neutralized the suppressive effect of the whole worm extract on OVA-specific antibody production. PAS-1 inhibited antibody production against a T-cell-dependent, but not a T-cell-independent, antigen in a dose-dependent way. IgM, IgG1, IgG2b, and also IgE and anaphylactic IgG1 levels were downregulated. In addition, PAS-1 inhibited OVA-specific delayed type hypersensitivity reactions in the footpad of mice, showing a potent immunosuppressive activity on both Th1 and Th2 responses that seems to be mediated by the induction of large amounts of IL-10 and IL-4. Indeed, PAS-1-specific spleen cells secreted sevenfold more IL-10 and threefold more IL-4 than OVA-specific cells in response to in vitro restimulation with the respective antigens. In conclusion, we showed that PAS-1, a single protein component from A. suum, maintains all its immunosuppressive properties.

  15. Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides.

    Science.gov (United States)

    Heintz, Udo; Meinhart, Anton; Winkler, Andreas

    2014-03-01

    Per-ARNT-Sim (PAS) domains are essential modules of many multi-domain signalling proteins that mediate protein interaction and/or sense environmental stimuli. Frequently, multiple PAS domains are present within single polypeptide chains, where their interplay is required for protein function. Although many isolated PAS domain structures have been reported over the last decades, only a few structures of multi-PAS proteins are known. Therefore, the molecular mechanism of multi-PAS domain-mediated protein oligomerization and function is poorly understood. The transcription factor PpsR from Rhodobacter sphaeroides is such a multi-PAS domain protein that, in addition to its three PAS domains, contains a glutamine-rich linker and a C-terminal helix-turn-helix DNA-binding motif. Here, crystal structures of two N-terminally and C-terminally truncated PpsR variants that comprise a single (PpsRQ-PAS1) and two (PpsRN-Q-PAS1) PAS domains, respectively, are presented and the multi-step strategy required for the phasing of a triple PAS domain construct (PpsRΔHTH) is illustrated. While parts of the biologically relevant dimerization interface can already be observed in the two shorter constructs, the PpsRΔHTH structure reveals how three PAS domains enable the formation of multiple oligomeric states (dimer, tetramer and octamer), highlighting that not only the PAS cores but also their α-helical extensions are essential for protein oligomerization. The results demonstrate that the long helical glutamine-rich linker of PpsR results from a direct fusion of the N-cap of the PAS1 domain with the C-terminal extension of the N-domain that plays an important role in signal transduction.

  16. Patient-specific port placement for laparoscopic surgery using atlas-based registration

    Science.gov (United States)

    Enquobahrie, Andinet; Shivaprabhu, Vikas; Aylward, Stephen; Finet, Julien; Cleary, Kevin; Alterovitz, Ron

    2013-03-01

    Laparoscopic surgery is a minimally invasive surgical approach, in which abdominal surgical procedures are performed through trocars via small incisions. Patients benefit by reduced postoperative pain, shortened hospital stays, improved cosmetic results, and faster recovery times. Optimal port placement can improve surgeon dexterity and avoid the need to move the trocars, which would cause unnecessary trauma to the patient. We are building an intuitive open source visualization system to help surgeons identify ports. Our methodology is based on an intuitive port placement visualization module and atlas-based registration algorithm to transfer port locations to individual patients. The methodology follows three steps:1) Use a port placement visualization module to manually place ports in an abdominal organ atlas. This step generates port-augmented abdominal atlas. This is done only once for a given patient population. 2) Register the atlas data with the patient CT data, to transfer the prescribed ports to the individual patient 3) Review and adjust the transferred port locations using the port placement visualization module. Tool maneuverability and target reachability can be tested using the visualization system. Our methodology would decrease the amount of physician input necessary to optimize port placement for each patient case. In a follow up work, we plan to use the transferred ports as starting point for further optimization of the port locations by formulating a cost function that will take into account factors such as tool dexterity and likelihood of collision between instruments.

  17. Impedance measurement techniques for one-port and two-port networks.

    Science.gov (United States)

    Bai, Mingsian R; Lo, Yi-Yang; Chen, You Siang

    2015-10-01

    A microphone array impedance matrix measurement technique is presented for linear and passive acoustic two-port networks. Two impedance tubes fitted with three non-uniformly spaced microphones are required in the measurement. The non-uniform spacing is intended to avoid ill-posedness problems in calculating two plane-wave components traveling in opposite directions. Based on the one-port measurement, acoustic two-port networks modeled with the source and the load connected are examined. Three experimental procedures, the two-load measurement method (TLMM), the reciprocal-constrained method (RCM), and the reciprocity-symmetry-constrained method (RSCM), are developed to measure the acoustic impedance matrix. Experiments are conducted for several acoustic two-port systems to verify the proposed techniques. The results demonstrate the efficacy of the three experimental procedures when applied to symmetrical and reciprocal systems. For asymmetrical systems, the TLMM and RCM are preferred over the RSCM for measuring the impedance matrix. On top of that, the non-uniform array in conjunction with TLMM is extended to a general electroacoustic two-port system, which can be regarded as a unique contribution of the present work.

  18. Sustainable port infrastructure, practical implementation of the green port concept

    National Research Council Canada - National Science Library

    Pavlic Bostjan; Cepak Franka; Sucic Boris; Peckaj Marko; Kandus Bogomil

    2014-01-01

    The overall idea and research interest related with the development of sustainable port infrastructure evolved around the core requirements of continuous reduction of negative environmental impacts...

  19. Statistics of Impedance and Scattering Matrices of Chaotic Microwave Cavities with Multiple Ports

    OpenAIRE

    Zheng, Xing; Antonsen Jr., Thomas M.; Ott, Edward

    2004-01-01

    The statistical model proposed in an accompanying paper is generalized to treat multiport scattering problems. Attention is first focused on two-port lossless systems and the model is shown to be consistent with Random Matrix Theory. The predictions are then tested by direct numerical simulation for a specific two-port cavity. Formula are derived for the average transmission and reflection coefficients in terms of the port radiation impedance. The cases of cavity with multiple ports, and with...

  20. The Industrial and Logistics Port Complex of Açu and its impacts on the drainage system and the urban structure of the Northern- Fluminense Region

    Directory of Open Access Journals (Sweden)

    Larissa Carneiro Rangel

    2014-02-01

    Full Text Available The construction of the Industrial and Logistics Port Complex of Açu will result in an accelerated process of urbanization directly related to population growth. When it no longer supports agricultural and livestock activities to meet the port activities, the region will have its urban, hydrological and economic dynamics changed. Given the fragility of the Quaternary Coastal, geomorphology of the region, these areas have occupation problems, and are subject to constant flooding. Therefore, it is necessary to make geomorphology studies of the area study so that development is can be planned, avoiding future environmental and territorial and urban problems.

  1. PAs in the ED: do physicians think they increase the malpractice risk?

    Science.gov (United States)

    Gifford, Alisa; Hyde, Mark; Stoehr, James D

    2011-06-01

    This study evaluates emergency physicians' perceptions of the malpractice risk posed by utilization of physician assistants (PAs) in emergency departments (EDs) in 2004 and again in 2009. A 16-question survey was mailed to a random sample of 1,000 active members of the American College of Emergency Physicians in 2004 and again in 2009. In both 2004 and 2009, 70% of the emergency physicians did not believe that PAs, when properly supervised, are more likely to commit malpractice than any other clinician. In both surveys, 80% of the respondents did not believe PAs were more likely to be sued for malpractice. A significant negative correlation was found between perceived risk of malpractice by PAs and the number of years physicians had worked with PAs or had worked in emergency medicine. From 2004 to 2009, the number of respondents practicing with PAs increased by 26%, the number directly supervising a PA in the ED increased by 19%, the number who thought PAs decreased patient wait times increased by 13%, and the number who reported that PAs increased patient satisfaction increased by 10%. As physicians gain clinical experience with PAs, their perceived risk of malpractice tends to decrease. These results may have implications for the utilization of PAs, particularly as EDs become more utilized for noncritical situations.

  2. A procedure for identifying significant environmental aspects in sea ports.

    Science.gov (United States)

    Darbra, R M; Ronza, A; Stojanovic, T A; Wooldridge, C; Casal, J

    2005-08-01

    A new methodology has been designed to identify and rank the significant environmental aspects in sea ports. The main objective of the Strategic Overview of Significant Environmental Aspects (SOSEA) is to help port managers to identify significant environmental aspects and to reinforce the awareness about them in order to prioritise work in environmental management. Developed in close collaboration with port environmental managers and tested in a set of ports, it is a user-friendly tool that can be applied in approximately half a working day. It is based on ISO 14001 vocabulary and requirements and it can be considered as the base for the implementation of any Environmental Management System for port communities.

  3. A history of PAs in the US Public Health Service.

    Science.gov (United States)

    McKinnon, Mark F; Elizondo, Epifanio; Bonfiglio, Susan M; Hunter-Buskey, Robin N; Placide, Frances P; Bunnell, Rebecca A

    2016-12-01

    Since 1798, the men and women of the Commissioned Corps of the US Public Health Service (USPHS), one of the seven US uniformed services, have served on the front lines of public health. Two hundred years after the start of the USPHS, the first physician assistant (PA) entered the service to carry on the tradition of protecting, promoting, and advancing the health and safety of the nation. These dedicated clinicians are involved in healthcare delivery to underserved and vulnerable populations, disease control and prevention, biomedical research, food and drug regulation, and national and international response efforts for natural and man-made disasters. This article describes how PAs in the Commissioned Corps of the USPHS have impacted the health and safety of not only the United States but also the international community.

  4. Die dramatiese discours in Pas de deux van Hugo Claus

    Directory of Open Access Journals (Sweden)

    R. Vaughan

    1990-05-01

    Full Text Available Drama is action, verbal drama is speech action, and the dramatic text is subject to a similar set of rules as that governing the extra-literary communication situation. Dramatic irony, the very essence of drama itself, is generated by a dual, mutually interactive process of communication, whereby the audience is “written into” the text in a way distinguishing it from other literary genres, and by a systematic flouting of the rules governing communication. Pas de deux demonstrates the peculiar duality of dramatic discourse by its complex exploitation of the breakdown/non-breakdown of Grice’s Co-operative Principle-. communication/non-communication becomes reversible and, therefore, mutually constitutive concepts “releasing meaning” and conveying the “ideology” of this play.

  5. Queuing theory models used for port equipment sizing

    Science.gov (United States)

    Dragu, V.; Dinu, O.; Ruscă, A.; Burciu, Ş.; Roman, E. A.

    2017-08-01

    The significant growth of volumes and distances on road transportation led to the necessity of finding solutions to increase water transportation market share together with the handling and transfer technologies within its terminals. It is widely known that the biggest times are consumed within the transport terminals (loading/unloading/transfer) and so the necessity of constantly developing handling techniques and technologies in concordance with the goods flows size so that the total waiting time of ships within ports is reduced. Port development should be achieved by harmonizing the contradictory interests of port administration and users. Port administrators aim profit increase opposite to users that want savings by increasing consumers’ surplus. The difficulty consists in the fact that the transport demand - supply equilibrium must be realised at costs and goods quantities transiting the port in order to satisfy the interests of both parties involved. This paper presents a port equipment sizing model by using queueing theory so that the sum of costs for ships waiting operations and equipment usage would be minimum. Ship operation within the port is assimilated to a mass service waiting system in which parameters are later used to determine the main costs for ships and port equipment.

  6. Interventional radiological imaging and treatment of port catheter dysfunctions; Angiografische Diagnostik und interventionelle Therapie von Portdysfunktionen

    Energy Technology Data Exchange (ETDEWEB)

    Kausche, S.; Nagel, S.N.; Teichgraeber, Ulf [Charite Universitaetsmedizin Berlin (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie

    2011-03-15

    To evaluate the impact of interventional radiological imaging and treatment of central venous port catheter complications. Materials and Methods: In this retrospective analysis 429 port catheter dysfunctions were evaluated in 393 port catheter systems for a total of 389 patients over a period of 10 years. The study included 193 (49.1 %) patients with radiologically implanted port catheter systems and 200 (50.9 %) referred patients with surgically implanted port systems. Port catheter dysfunctions were subdivided into early and late complications as well as into non-thrombotic and thrombotic events. After administration of contrast medium, the port system was visualized using digital subtraction angiography. Data were retrospectively collected from the in-house databases and then analyzed descriptively. Results: 429 contrast media injections via port catheters were performed in 393 port catheter systems. There were 359 (83.7 %) late complications and 70 (16.3 %) early complications. In 299 (69.7 %) cases thrombotic events occurred and 130 (30.3 %) non-thrombotic events were recorded. The most common reason for contrast media injection via port catheter system was port catheter-related thrombosis in 269 (62.7 %) cases. 70 (16.3 %) catheter migrations and 30 (7.0 %) fibrin sheath formations were detected. 18 (4.2 %) port needle malfunctions could be resolved through needle exchange. All 15 (3.5 %) catheter disconnections had to be revised in all cases. Also six port explantations were performed in 6 (1.4 %) catheter fractures. Conclusion: The possibilities of angiographic imaging and interventional radiological correction of port catheter dysfunctions must be exploited fully in order to avoid premature port explantation. (orig.)

  7. A multi-port power electronics interface for battery powered electric vehicles: Application of inductively coupled wireless power transfer and hybrid energy storage system

    Science.gov (United States)

    McDonough, Matthew Kelly

    Climate change, pollution, and geopolitical conflicts arising from the extreme wealth concentrations caused by fossil fuel deposits are just a few of the side-effects of the way that we fuel our society. A new method to power our civilization is becoming more and more necessary. Research for new, more sustainable fuel sources is already underway due to research in wind, solar, geothermal, and hydro power. However this focus is mainly on stationary applications. A large portion of fossil fuel usage comes from transportation. Unfortunately, the transition to cleaner transportation fuels is being stunted by the inability to store adequate amounts of energy in electro-chemical batteries. The idea of charging while driving has been proposed by many researchers, however several challenges still exist. In this work some of these challenges are addressed. Specifically, the ability to route power from multiple sources/loads is investigated. Special attention is paid to adjusting the time constant of particular converters, namely the battery and ultra-capacitor converters to reduce the high frequency and high magnitude current components applied to the battery terminals. This is done by developing a closed loop model of the entire multi-port converter, including the state of charge of the ultra-capacitors. The development of closed loop models and two experimental testbeds for use as stationary vehicle charging platforms with their unique set of sources/loads are presented along-side an on-board charger to demonstrate the similarities and differences between stationary charging and mobile charging. Experimental results from each are given showing that it is not only possible, but feasible to utilize Inductively Coupled Wireless Power Transfer (ICWPT) to charge a battery powered electric vehicle while driving and still protect the life-span of the batteries under the new, harsher conditions generated by the ICWPT system.

  8. E-Commerce in Ports

    Directory of Open Access Journals (Sweden)

    Elen Twrdy

    2002-01-01

    Full Text Available EDI (Electronic Data Interchange and electronic businessshould be looked upon as a natural evolution in the internationaltrade and transport cycle. One of the principal reasonsfor starting to use EDI are the heaps of documents written,shifted, handled, conected, transcribed and copied for normalbusiness and administrative transactions. EDJ and in generalelectronic business would have none of the disadvantages ofpaper documents and have already brought substantial benefitsand savings to companies that implement it.Most port community systems today still do not provide forelectronic transfer of funds or for electronic interchange of invoicesand other trade documents, for instance bills of lading.Such services are specific toe-business and they are the necessarytransport-related documents.

  9. Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides

    Energy Technology Data Exchange (ETDEWEB)

    Heintz, Udo; Meinhart, Anton; Winkler, Andreas, E-mail: andreas.winkler@mpimf-heidelberg.mpg.de [Max Planck Institute for Medical Research, Heidelberg (Germany)

    2014-03-01

    Crystal structures of two truncated variants of the transcription factor PpsR from R. sphaeroides are presented that enabled the phasing of a triple PAS domain construct. Together, these structures reveal the importance of α-helical PAS extensions for multi-PAS domain-mediated protein oligomerization and function. Per–ARNT–Sim (PAS) domains are essential modules of many multi-domain signalling proteins that mediate protein interaction and/or sense environmental stimuli. Frequently, multiple PAS domains are present within single polypeptide chains, where their interplay is required for protein function. Although many isolated PAS domain structures have been reported over the last decades, only a few structures of multi-PAS proteins are known. Therefore, the molecular mechanism of multi-PAS domain-mediated protein oligomerization and function is poorly understood. The transcription factor PpsR from Rhodobacter sphaeroides is such a multi-PAS domain protein that, in addition to its three PAS domains, contains a glutamine-rich linker and a C-terminal helix–turn–helix DNA-binding motif. Here, crystal structures of two N-terminally and C-terminally truncated PpsR variants that comprise a single (PpsR{sub Q-PAS1}) and two (PpsR{sub N-Q-PAS1}) PAS domains, respectively, are presented and the multi-step strategy required for the phasing of a triple PAS domain construct (PpsR{sub ΔHTH}) is illustrated. While parts of the biologically relevant dimerization interface can already be observed in the two shorter constructs, the PpsR{sub ΔHTH} structure reveals how three PAS domains enable the formation of multiple oligomeric states (dimer, tetramer and octamer), highlighting that not only the PAS cores but also their α-helical extensions are essential for protein oligomerization. The results demonstrate that the long helical glutamine-rich linker of PpsR results from a direct fusion of the N-cap of the PAS1 domain with the C-terminal extension of the N-domain that

  10. Factor structure of the PAS-ADD Checklist with adults with intellectual disabilities.

    OpenAIRE

    Hatton, Chris; Taylor, John

    2008-01-01

    BACKGROUND: The PAS-ADD Checklist is designed to screen for likely mental health problems in people with intellectual disabilities (ID). The specificity of recommended subscales derived from diagnostic criteria is unclear. This paper therefore investigates the factor structure of the PAS-ADD Checklist to determine the adequacy of empirically derived subscales. \\ud METHOD: A total of 1,115 informants who had known service users for a median of 24 months completed the PAS-ADD Checklist on 1,155...

  11. A Comparative Analysis between GaN-Based Current and Voltage Mode Class-D and E PAs for Communications

    Science.gov (United States)

    2017-03-01

    A Comparative Analysis between GaN-Based Current and Voltage Mode Class-D and E PAs for Communications Shishir Shukla and Jennifer Kitchen...programmability and efficiency. Radar and imaging systems that use constant envelope waveforms may exploit the advantages of highly nonlinear, or switched...709–717, Dec 2005. 7. T. Suetsugu and M. K. Kazimierczuk, “Off-Nominal Operation of Class-E Amplifier at Any Duty Ratio ,” IEEE Transactions on

  12. The Immunology Database and Analysis Portal (ImmPort)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The ImmPort system serves as a long-term, sustainable archive of immunology research data generated by investigators mainly funded through the NIAID/DAIT. The core...

  13. Role of the PAS sensor domains in the Bacillus subtilis sporulation kinase KinA.

    Science.gov (United States)

    Winnen, Brit; Anderson, Eric; Cole, James L; King, Glenn F; Rowland, Susan L

    2013-05-01

    Histidine kinases are sophisticated molecular sensors that are used by bacteria to detect and respond to a multitude of environmental signals. KinA is the major histidine kinase required for initiation of sporulation upon nutrient deprivation in Bacillus subtilis. KinA has a large N-terminal region (residues 1 to 382) that is uniquely composed of three tandem Per-ARNT-Sim (PAS) domains that have been proposed to constitute a sensor module. To further enhance our understanding of this "sensor" region, we defined the boundaries that give rise to the minimal autonomously folded PAS domains and analyzed their homo- and heteroassociation properties using analytical ultracentrifugation, nuclear magnetic resonance (NMR) spectroscopy, and multiangle laser light scattering. We show that PAS(A) self-associates very weakly, while PAS(C) is primarily a monomer. In contrast, PAS(B) forms a stable dimer (K(d) [dissociation constant] of PAS domains revealed a critical role for PAS(B), but not PAS(A), in autophosphorylation of KinA. Our findings suggest that dimerization of PAS(B) is important for keeping the catalytic domain of KinA in a functional conformation. We use this information to propose a model for the structure of the N-terminal sensor module of KinA.

  14. Principles of subcutaneous port placement.

    Science.gov (United States)

    Gonda, Shaun J; Li, Ruizong

    2011-12-01

    The introduction of totally implantable subcutaneous devices in the early 1980s provided patients with secure, reliable venous access and also gave them the ability to move more freely and have a more normal lifestyle with these devices in place. The most common totally implantable device used today is the subcutaneous port. These ports consist of an injection port connected to a catheter. Ports provide a number of advantages compared with other venous catheters; the most important is the reduced risk of infection. These devices have significantly lower rates of infection than nontunneled and tunneled catheters. Additional advantages include less frequent irrigation and minimal home care, and they are less prone to environmental or cutaneous contamination when not being accessed. This article will focus on the placement of these ports. Copyright © 2011 Elsevier Inc. All rights reserved.

  15. Container Traffic In European Ports

    Directory of Open Access Journals (Sweden)

    Elen Twrdy

    2004-03-01

    Full Text Available Over the last fifteen years the European transport markethas witnessed a growth of container traffic which today reachesapproximately 50 million TEU per year. From 1997 to 2002,container traffic in the northern European ports increased from14 to 20.6 million TEU per year, in the ports of the westernMedite"anean from 6 to 10 million TEU per year, and in thenorthern Adriatic ports from 0. 69 to 0. 74 million TEU per year.The ports of the northern Adriatic are located in three states(Slovenia, Croatia and Italy with different statuses in relationto the common European market. In addition, different developmentlevels of these states are reflected in different levels ofinternational commercial exchange, the development of the existinginfrastructure and plans for the construction of new infrastructures.However, all three countries share a common goaltoincrease their competitiveness in comparison with the westemEuropean ports.

  16. Anxiety in early Parkinson's disease: Validation of the Italian observer-rated version of the Parkinson Anxiety Scale (OR-PAS).

    Science.gov (United States)

    Santangelo, Gabriella; Falco, Fabrizia; D'Iorio, Alfonsina; Cuoco, Sofia; Raimo, Simona; Amboni, Marianna; Pellecchia, Maria Teresa; Longo, Katia; Vitale, Carmine; Barone, Paolo

    2016-08-15

    Anxiety disorders are common in Parkinson's Disease (PD) and their identification is relevant even at early stages. The Parkinson Anxiety Scale (PAS) evaluates anxiety in PD; it was used only in the original validation study in PD patients mainly at 2-3 stages of Hoehn & Yahr system (H&Y). The study aimed to investigate psychometric properties of observer-rated version of the PAS (OR-PAS), prevalence rate of anxiety and its features, compared with diagnostic criteria in early PD patients. A sample of 101 PD patients with H&Y:1-2 underwent the OR-PAS. To assess convergent and divergent validity, PD patients underwent Beck Anxiety Inventory, and scales assessing depression, apathy, anhedonia and cognition. To diagnose anxiety disorders, Mini International Neuropsychiatric Inventory was used as gold standard. A "receiver operating characteristics" curve was obtained; positive and negative predictive values were calculated for different cut-off points of the OR-PAS and its subscales. There was no missing data, no floor and ceiling effects; mean score was 12.2±10.1; Cronbach's alpha was 0.899. The OR-PAS showed good convergent and divergent validity. Maximum discrimination was obtained with a cut-off score of 8.5. The anxiety occurred in 59 patients (58.4%). The OR-PAS is a reliable and valid screening instrument for assessing anxiety in patients at early PD. Anxiety was found in 58.4% of PD patients, demonstrating that anxiety occurs even at early stages. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. 78 FR 36014 - Deepwater Port License Application: Liberty Natural Gas, LLC, Port Ambrose Deepwater Port

    Science.gov (United States)

    2013-06-14

    ... Maritime Administration Deepwater Port License Application: Liberty Natural Gas, LLC, Port Ambrose... received an application from Liberty Natural Gas, LLC for all Federal authorizations required for a license... Act, as amended. Summary of the Application Liberty Natural Gas, LLC is proposing to construct, own...

  18. Mapping potential freshwater services, and their representation within Protected Areas (PAs, under conditions of sparse data. Pilot implementation for Cambodia

    Directory of Open Access Journals (Sweden)

    Leonardo Sáenz

    2016-07-01

    Full Text Available Freshwater is arguably one of Earth’s most threatened natural resources, on which more than 7 billion people depend. Pressures on freshwater resources from infrastructure, resource development, agricultural pollution and deforestation are mounting, particularly in developing countries. To date, conservation responses such as Protected Areas (PAs have not typically targeted freshwater ecosystems and their services, and thus little is known about the effectiveness of these efforts in protecting them. This paper proposes and pilots an innovative freshwater services metrics framework to quantify the representation of potential freshwater services in PAs under conditions of scarce data, with a pilot application for Cambodia. Our results indicate that conservation actions have more effectively represented potential freshwater regulation services than potential freshwater provisioning services, with major rivers remaining generally unprotected. Results from the framework are then used to propose a series of context and region specific management options to improve the conservation of freshwater services in Cambodia. There is an acute need for such management options, as the country’s food security depends largely on important freshwater ecosystems such as the Tonle Sap Lake and the deep water pools systems of the Mekong River. The framework proposed can be applied in other countries or large river basins to explore the degree of representation of freshwater services within PAs systems, under conditions of sparse data.

  19. Evolution, functional divergence and conserved exon-intron structure of bHLH/PAS gene family.

    Science.gov (United States)

    Yan, Jun; Ma, Zhaowu; Xu, Xiaopeng; Guo, An-Yuan

    2014-02-01

    bHLH/PAS genes encode a family of basic helix-loop-helix (bHLH) transcription factors with bHLH, PAS and PAS_3 domain. bHLH/PAS genes are involved in many essential physiological and developmental processes, such as hypoxic response neural development, the circadian clock, and learning ability. Despite their important functions, the origin and evolution of this bHLH/PAS gene family has yet to be elucidated. In this study, we aim to explore the origin, evolution, gene structure conservation of this gene family and provide a model to analyze the evolution of other gene families. Our results show that genes of the bHLH/PAS family only exist in metazoans. They may have originated from the common ancestor of metazoans and expanded into vertebrates. We identified bHLH/PAS genes in more than ten species representing the main lineages and constructed the phylogenetic trees (Beyasian, ML and NJ) to classify them into three groups. The exon-intron structure analysis revealed that a relatively conserved "1001-0210" eight-exon structure exists in most groups and lineages. In addition, we found the exon fusion pattern in several groups in this conserved eight-exon structure. Further analysis indicated that bHLH/PAS protein paralogs evolved from several gene duplication events followed by functional divergence and purifying selection. We presented a phylogenetic model to describe the evolutionary history of the exon structures of bHLH/PAS genes. Taken together, our study revealed the evolutionary model, functional divergence and gene structure conservation of bHLH/PAS genes. These findings provide clues for the functional and evolutionary mechanism of bHLH/PAS genes.

  20. Storage of apheresis platelet concentrates after manual replacement of >95% of plasma with PAS 5.

    Science.gov (United States)

    Morrison, A; McMillan, L; Radwanski, K; Blatchford, O; Min, K; Petrik, J

    2014-10-01

    Recently, a glucose- and bicarbonate-containing additive solution termed PAS 5 demonstrated acceptable 7-day platelet storage after >95% plasma replacement with PAS on the day of collection (Day 0). In this study, we examined platelet storage in >95% PAS 5 after manual washing of Day 1 apheresis platelets in plasma collected using either the Amicus or Trima plateletpheresis devices. Triple platelet donations in plasma were obtained from Amicus (n = 10) and Trima (n = 10) plateletpheresis devices and stored overnight before being centrifuged and manually processed into three units with the following storage media: 100% plasma, >95% PAS 5 or 65% PAS 5/35% plasma. Platelet units were sampled on Days 1, 5 and 7 of storage using a range of tests recommended by the UK guidelines. The majority of in vitro assay results for platelets in PAS 5 were similar to results in paired 100% plasma platelets (controls). The pH of PAS 5 stored platelet units was above the UK recommended guidelines of 7·4 by Day 5. PAS 5 platelets were no more activated than controls as evidenced by comparable soluble P-selectin levels and CD62p and CD42b expression. PAS 5 platelets also exhibited adhesion and aggregation profiles higher than (Day 1) or comparable to (Days 5 and 7) controls as measured by Impact R. The 7-day in vitro storage parameters investigated were comparable between >95% PAS 5 and 100% plasma platelets derived from both Amicus and Trima plateletpheresis devices, with the exception that lactose dehydrogenase release rate and pH were significantly higher in PAS 5 units. © 2014 International Society of Blood Transfusion.

  1. Vectorization, parallelization and porting of nuclear codes (porting). Progress report fiscal 1998

    Energy Technology Data Exchange (ETDEWEB)

    Nemoto, Toshiyuki; Kawai, Wataru; Ishizuki, Shigeru [Fujitsu Ltd., Tokyo (Japan); Kawasaki, Nobuo; Kume, Etsuo; Adachi, Masaaki; Ogasawara, Shinobu [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Yatake, Yo-ichi [Hitachi Ltd., Tokyo (Japan)

    2000-03-01

    Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system, the AP3000 system and the Paragon system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. We dealt with 12 codes in fiscal 1998. These results are reported in 3 parts, i.e., the vectorization and parallelization on vector processors part, the parallelization on scalar processors part and the porting part. In this report, we describe the porting. In this porting part, the porting of Monte Carlo N-Particle Transport code MCNP4B2 and Reactor Safety Analysis code RELAP5 on the AP3000 are described. In the vectorization and parallelization on vector processors part, the vectorization of General Tokamak Circuit Simulation Program code GTCSP, the vectorization and parallelization of Molecular Dynamics Ntv Simulation code MSP2, Eddy Current Analysis code EDDYCAL, Thermal Analysis Code for Test of Passive Cooling System by HENDEL T2 code THANPACST2 and MHD Equilibrium code SELENEJ on the VPP500 are described. In the parallelization on scalar processors part, the parallelization of Monte Carlo N-Particle Transport code MCNP4B2, Plasma Hydrodynamics code using Cubic Interpolated propagation Method PHCIP and Vectorized Monte Carlo code (continuous energy model/multi-group model) MVP/GMVP on the Paragon are described. (author)

  2. Factor Structure of the PAS-ADD Checklist with Adults with Intellectual Disabilities

    Science.gov (United States)

    Hatton, Chris; Taylor, John J.

    2008-01-01

    Background: The PAS-ADD Checklist is designed to screen for likely mental health problems in people with intellectual disabilities (ID). The specificity of recommended subscales derived from diagnostic criteria is unclear. This paper therefore investigates the factor structure of the PAS-ADD Checklist to determine the adequacy of empirically…

  3. Screening for Psychiatric Symptoms: PAS-ADD Checklist Norms for Adults with Intellectual Disabilities

    Science.gov (United States)

    Taylor, J. L.; Hatton, C.; Dixon, L.; Douglas, C.

    2004-01-01

    The Psychiatric Assessment Schedule for Adults with Developmental Disabilities Checklist (PAS-ADD Checklist) is a screening instrument designed to help carers recognize likely mental health problems in people with intellectual disabilities (ID). To date there are no published PAS-ADD Checklist data on a large nonpsychiatric population of adults…

  4. Within-host competition between barley yellow dwarf-PAV and -PAS.

    Science.gov (United States)

    Hall, Gerod S; Little, Damon P

    2013-06-01

    The PAV and PAS species of barley yellow dwarf virus (Luteoviridae) share hosts, vectors, and have sympatric distributions. To better understand how competition between species influences virus growth within the host, transmission rate between hosts, and ultimately virus population structure two experiments were conducted. The first experiment varied the order of PAV and PAS inoculation and the time interval between the first and second inoculation. Relative virus concentration was measured at 8, 20, 33, and 45 days after primary virus inoculation (dpi). Regardless of the order of inoculation or the length of time between inoculations, PAV dominated the virus population by 33 dpi (PAV concentration ranged from 55% to 89%). The second experiment measured the rate of vector transmission from single and multiple infections. From single infections, the transmission rate was 67% for PAV and 60% for PAS. PAV had significantly greater odds of transmission for all competition treatments-except if PAS was given a 15-day head start before inoculation with PAV. In the latter treatment, PAS was transmitted with a greater frequency than PAV, but the difference was not statistically significant. Our data show persistent co-infection between PAV and PAS, but PAV is more likely to be transmitted from mixed infections. Thus, within-host interactions between PAV and PAS create conditions that promote both the competitive exclusion of PAS, as well as co-existence between species and the maintenance of genetic diversity in the host community. Copyright © 2013 Elsevier B.V. All rights reserved.

  5. Ligand binding PAS domains in a genomic, cellular, and structural context

    Science.gov (United States)

    Henry, Jonathan T.; Crosson, Sean

    2012-01-01

    Per-Arnt-Sim (PAS) domains occur in proteins from all kingdoms of life. In the bacterial kingdom, PAS domains are commonly positioned at the amino terminus of signaling proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, and methyl-accepting chemotaxis proteins. Although these domains are highly divergent at the primary sequence level, the structures of dozens of PAS domains across a broad section of sequence space have been solved, revealing a conserved three-dimensional architecture. An all-versus-all alignment of 63 PAS structures demonstrates that the PAS domain family forms structural clades on the basis of two principal variables: (a) topological location inside or outside the plasma membrane and (b) the class of small molecule that they bind. The binding of a chemically diverse range of small-molecule metabolites is a hallmark of the PAS domain family. PAS ligand binding either functions as a primary cue to initiate a cellular signaling response or provides the domain with the capacity to respond to secondary physical or chemical signals such as gas molecules, redox potential, or photons. This review synthesizes the current state of knowledge of the structural foundations and evolution of ligand recognition and binding by PAS domains. PMID:21663441

  6. Ligand-binding PAS domains in a genomic, cellular, and structural context.

    Science.gov (United States)

    Henry, Jonathan T; Crosson, Sean

    2011-01-01

    Per-Arnt-Sim (PAS) domains occur in proteins from all kingdoms of life. In the bacterial kingdom, PAS domains are commonly positioned at the amino terminus of signaling proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, and methyl-accepting chemotaxis proteins. Although these domains are highly divergent at the primary sequence level, the structures of dozens of PAS domains across a broad section of sequence space have been solved, revealing a conserved three-dimensional architecture. An all-versus-all alignment of 63 PAS structures demonstrates that the PAS domain family forms structural clades on the basis of two principal variables: (a) topological location inside or outside the plasma membrane and (b) the class of small molecule that they bind. The binding of a chemically diverse range of small-molecule metabolites is a hallmark of the PAS domain family. PAS ligand binding either functions as a primary cue to initiate a cellular signaling response or provides the domain with the capacity to respond to secondary physical or chemical signals such as gas molecules, redox potential, or photons. This review synthesizes the current state of knowledge of the structural foundations and evolution of ligand recognition and binding by PAS domains.

  7. Does DSM-IV Have Equivalents for the Parental Alienation Syndrome (PAS) Diagnosis?

    Science.gov (United States)

    Gardner, Richard A.

    2003-01-01

    Child custody evaluators commonly find themselves confronted with resistance when they attempt to use the term parental alienation syndrome (PAS) in courts of law. The purpose of this article is to elucidate the reasons for the reluctance to use the PAS diagnosis and the applicability of parental alienation, as well as current DSM-IV substitute…

  8. An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.

    Science.gov (United States)

    Ortmayer, Mary; Lafite, Pierre; Menon, Binuraj R K; Tralau, Tewes; Fisher, Karl; Denkhaus, Lukas; Scrutton, Nigel S; Rigby, Stephen E J; Munro, Andrew W; Hay, Sam; Leys, David

    2016-11-24

    The universal Per-ARNT-Sim (PAS) domain functions as a signal transduction module involved in sensing diverse stimuli such as small molecules, light, redox state and gases. The highly evolvable PAS scaffold can bind a broad range of ligands, including haem, flavins and metal ions. However, although these ligands can support catalytic activity, to our knowledge no enzymatic PAS domain has been found. Here we report characterization of the first PAS enzyme: a haem-dependent oxidative N-demethylase. Unrelated to other amine oxidases, this enzyme contains haem, flavin mononucleotide, 2Fe-2S and tetrahydrofolic acid cofactors, and specifically catalyses the NADPH-dependent oxidation of dimethylamine. The structure of the α subunit reveals that it is a haem-binding PAS domain, similar in structure to PAS gas sensors. The dimethylamine substrate forms part of a highly polarized oxygen-binding site, and directly assists oxygen activation by acting as both an electron and proton donor. Our data reveal that the ubiquitous PAS domain can make the transition from sensor to enzyme, suggesting that the PAS scaffold can support the development of artificial enzymes.

  9. Port health problems.

    Science.gov (United States)

    James, M J

    1976-08-01

    As quarantine control of international travellers dies away, health screening of immigrants becomes more important. Port health controls attempt to identify the sick immigrant, thereby limiting disease spread among susceptibles and sparking early treatment. Port health controls also ease the impact of immigrants arriving at destinations by alerting relevant authorities so that they can begin health education procedures early, if they wish. Two problems arise: some destination authorities make little attempt to trace their immigrants and even those that do cannot find more than 70 per cent so notified. For receiving communities the most important disease the immigrant may carry or later develop is tuberculosis. In the indigenous population the incidence of this disease is decaying exponentially but, in communities of recent immigrants, may be stable or even rising. This means that in about ten years the great majority of new tuberculosis cases will be in recent immigrants, unless better preventive techniques are used. The overall trend is likely to be a fall in the number of cases, but the disproportion may provoke problems. What can be done? Assuming incoming immigrants are typical of their country of origin, many must enter Britain mantoux-negative, a fact supported by various destination authorities here which have performed testing. So, the logical solution is to ensure that all receive BCG vaccination, preferably before they migrate or otherwise as they enter Britain, and to ensure their babies born later in Britain also receive the protection of BCG vaccination. Consumption of medical services by the travelling public increases with the number of travellers and, as more people penetrate romantic but unhealthy areas formerly inaccessible, importation of communicable disease also increases. Many of these diseases could be prevented by good advice but, unfortunately, unfamiliarity blunts the edge of prophylaxis and diagnosis. Airport experience indicates that the

  10. [Implantable venous access ports, nursing practices].

    Science.gov (United States)

    Ourliac, Maryse; Dijols-Lécuyer, Isabelle

    2016-05-01

    Following the publication of national recommendations regarding the handling of implantable venous access ports, an observation audit was carried out in a hospital in 2013. This enabled an assessment of the existing system to be performed, current practices to be compared with the hospital's protocol and adapted corrective measures to be put in place. A further audit carried out in 2015 was particularly encouraging. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  11. Enterprise Considerations for Ports and Protocols

    Science.gov (United States)

    2016-10-21

    may be added to explicitly permit messages to and from a web server using HTTP on port 80 (e.g., 123.345.567.789:80). Firewalls that cover larger...protected. Endpoint protection is embedded in the standard ELS web service implementation. The new functions that are added in the Server are...permitted, others blocked. However, many appliances now have such functionality and the server or service may have a host-based security system that can

  12. Stopcock lumen contamination does not reflect the full burden of bacterial intravenous tubing contamination: analysis using a novel injection port.

    Science.gov (United States)

    Muffly, Matthew K; Beach, Michael L; Tong, Yi Cai Isaac; Yeager, Mark P

    2010-11-01

    Prior clinical studies have used injection port lumen culture as a marker of intravenous (IV) fluid system contamination. We hypothesized that culturing injected saline (effluent) is a more sensitive method of detecting IV fluid system bacterial contamination than lumen culture. To test this hypothesis, we compared the incidence of lumen contamination with effluent contamination in a simulated setting. We also measured the effect of a novel injection port protective device (Port Guide; Matrix Tooling, Inc, Wood Dale, IL) on contamination. In this ex vivo study, 33 providers performed 5 injections of 1 mL sterile saline into each of 4 injection port designs: (1) stopcock, (2) stopcock with Port Guide, (3) stopcock with disinfectable needleless closed connector (DNCC), and (4) stopcock with DNCC and Port Guide. The primary outcome was the rate of effluent contamination with simultaneously contaminated injection port lumen. Bacterial organisms were recovered from the effluent in 17 of the 132 injection ports evaluated. Of those 17 injection ports with contaminated effluent, 4 injection port lumens were simultaneously contaminated (24%). Additionally, use of the stopcock with Port Guide significantly reduced effluent contamination. Effluent culture is a more sensitive marker of IV fluid system contamination than injection port lumen culture. A novel protective device on the stopcock (Port Guide) significantly reduced IV fluid system bacterial contamination. Copyright © 2010 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

  13. All-encomPASsing regulation of β-cells: PAS domain proteins in β-cell dysfunction and diabetes.

    Science.gov (United States)

    Sabatini, Paul V; Lynn, Francis C

    2015-01-01

    As a sensory micro-organ, pancreatic β-cells continually respond to nutritional signals and neuroendocrine input from other glucoregulatory organs. This sensory ability is essential for normal β-cell function and systemic glucose homeostasis. Period circadian protein (Per)-aryl hydrocarbon receptor nuclear translocator protein (Arnt)-single-minded protein (Sim) (PAS) domain proteins have a conserved role as sensory proteins, critical in adaptation to changes in voltage, oxygen potential, and xenobiotics. Within β-cells, PAS domain proteins such as hypoxia inducible factor 1α (Hif1α), Arnt, PAS kinase, Bmal1, and Clock respond to disparate stimuli, but act in concert to maintain proper β-cell function. Elucidating the function of these factors in islets offers a unique insight into the sensing capacity of β-cells, the consequences of impaired sensory function, and the potential to develop novel therapeutic targets for preserving β-cell function in diabetes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. Research on the Logistics Supply Chain in Port Logistics Transportation

    OpenAIRE

    Wang Yan-liang

    2013-01-01

    The aim of this study is to improve and increase the logistics system effectiveness and to solve the problem of optimal movement of different flows. Logistics transport carrying the world on material resources transfer exchange important mission and economic development and our lives are closely linked, logistics chain logistics transport occupies an important position and in the e logistics chain in port logistics has play a decisive role. For many coastal countries port logistics is the eco...

  15. Gulf Coast. Ports for Naval Defense

    Science.gov (United States)

    1993-09-01

    187 feet. HIGHWA Y A suitable network 69 a of highways serves the Port of Beau- I mont . The port has 96 access to Interstate 10 and US Routes 0 69...Commander 1312th Medium Port Command 1620 South Wilmington Avenue Compton, CA 90220-5115 (1) Commander 6632d Port Security Detachment 2345 Barranca

  16. Open Issues and Proposals in the IT Security Management of Commercial Ports: The S-PORT National Case

    OpenAIRE

    Polemi, Nineta; Ntouskas, Theodoros

    2012-01-01

    Part 13: Short Papers; International audience; Commercial ports are large scale infrastructures which their Information and Telecommunication (PIT) systems offer critical services and host sensitive data. However the current maritime legislation or standardization efforts do not sufficiently cover the IT security of the commercial ports. Identifying these needs we propose a collaborative environment offering security management services including a targeted risk management methodology which w...

  17. Economic Contribution of Regional Feeder Ports to The Local Economy In Indonesia

    Directory of Open Access Journals (Sweden)

    Ibnu Syabri

    2017-07-01

    Full Text Available Indonesia regional feeder ports’ main function is to serve marine transport activities between regency/city in a province in limited quantities. The intention of the government to make marine transportation as the backbone of national logistic transportation system puts these ports to an important position, as suppliers for the main and/or collector ports and as goods distribution centers for the region from the bigger ports. Not only as a provider of accessibility between regions, regional feeder ports should be seen as an investation to boost regional economy. This study aims to explain the influences of regional feeder ports on regency/city economy, based on the port types: (1 cargo ports, and (2 cargo & passengers ports. Results showed that both types of ports have positive influences on the regency/city economy, although it is not related to region’s economic base sector. Cargo ports which are mainly located on west area of Indonesia, supports the region’s economy more than cargo & passenger ports which are mainly located on the east.

  18. 3D visualization of port simulation.

    Energy Technology Data Exchange (ETDEWEB)

    Horsthemke, W. H.; Macal, C. M.; Nevins, M. R.

    1999-06-14

    Affordable and realistic three dimensional visualization technology can be applied to large scale constructive simulations such as the port simulation model, PORTSIM. These visualization tools enhance the experienced planner's ability to form mental models of how seaport operations will unfold when the simulation model is implemented and executed. They also offer unique opportunities to train new planners not only in the use of the simulation model but on the layout and design of seaports. Simulation visualization capabilities are enhanced by borrowing from work on interface design, camera control, and data presentation. Using selective fidelity, the designers of these visualization systems can reduce their time and efforts by concentrating on those features which yield the most value for their simulation. Offering the user various observational tools allows the freedom to simply watch or engage in the simulation without getting lost. Identifying the underlying infrastructure or cargo items with labels can provide useful information at the risk of some visual clutter. The PortVis visualization expands the PORTSIM user base which can benefit from the results provided by this capability, especially in strategic planning, mission rehearsal, and training. Strategic planners will immediately reap the benefits of seeing the impact of increased throughput visually without keeping track of statistical data. Mission rehearsal and training users will have an effective training tool to supplement their operational training exercises which are limited in number because of their high costs. Having another effective training modality in this visualization system allows more training to take place and more personnel to gain an understanding of seaport operations. This simulation and visualization training can be accomplished at lower cost than would be possible for the operational training exercises alone. The application of PORTSIM and PortVis will lead to more efficient

  19. Port of Hamburg - masterpiece of logistic: Presentation held at the Workshop Maritime and Logistics - Partnerships for Global Competitiveness, 24.10.2013, Montreal

    OpenAIRE

    Jahn, Carlos

    2013-01-01

    The port of Hamburg represents a masterpiece of logistics. It not only delivers performance but also masters complexity. In addition it provides connectivity to other continents and within Europe. The "Port River Information System Elbe" and the "Port Road Management" contribute to the efficiency of the port. All this is topped off with the fact that the port of Hamburg also strives to eco-friendliness.

  20. H2O2 production rate in Lactobacillus johnsonii is modulated via the interplay of a heterodimeric flavin oxidoreductase with a soluble 28 Kd PAS domain containing protein.

    Directory of Open Access Journals (Sweden)

    Ricardo B Valladares

    2015-07-01

    Full Text Available Host and commensals crosstalk, mediated by reactive oxygen species (ROS, has triggered a growing scientific interest to understand the mechanisms governing such interaction. However, the majority of the scientific studies published do not evaluate the ROS production by commensals bacteria. In this context we recently showed that Lactobacillus johnsonii N6.2, a strain of probiotic value, modulates the activity of the critical enzymes 2,3-indoleamine dioxygenase via H2O2 production. L. johnsonii N6.2 by decreasing IDO activity, is able to modify the tryptophan/kynurenine ratio in the host blood with further systemic consequences. Understanding the mechanisms of H2O2 production is critical to predict the probiotic value of these strains and to optimize bacterial biomass production in industrial processes. We performed a transcriptome analysis to identify genes differentially expressed in L. johnsonii N6.2 cells collected from cultures grown under different aeration conditions. Herein we described the biochemical characteristics of a heterodimeric FMN reductase (FRedA/B whose in vitro activity is controlled by LjPAS protein with a typical Per-Arnst-Sim (PAS sensor domain. Interestingly, LjPAS is fused to the FMN reductase domains in other lactobacillaceae. In L. johnsonii, LjPAS is encoded by an independent gene which expression is repressed under anaerobic conditions (>3 fold. Purified LjPAS was able to slow down the FRedA/B initial activity rate when the holoenzyme precursors (FredA, FredB and FMN were mixed in vitro. Altogether the results obtained suggest that LjPAS module regulates the H2O2 production helping the cells to minimize oxidative stress in response to environmental conditions.

  1. H2O2 production rate in Lactobacillus johnsonii is modulated via the interplay of a heterodimeric flavin oxidoreductase with a soluble 28 Kd PAS domain containing protein.

    Science.gov (United States)

    Valladares, Ricardo B; Graves, Christina; Wright, Kaitlyn; Gardner, Christopher L; Lorca, Graciela L; Gonzalez, Claudio F

    2015-01-01

    Host and commensals crosstalk, mediated by reactive oxygen species (ROS), has triggered a growing scientific interest to understand the mechanisms governing such interaction. However, the majority of the scientific studies published do not evaluate the ROS production by commensals bacteria. In this context we recently showed that Lactobacillus johnsonii N6.2, a strain of probiotic value, modulates the activity of the critical enzymes 2,3-indoleamine dioxygenase via H2O2 production. L. johnsonii N6.2 by decreasing IDO activity, is able to modify the tryptophan/kynurenine ratio in the host blood with further systemic consequences. Understanding the mechanisms of H2O2 production is critical to predict the probiotic value of these strains and to optimize bacterial biomass production in industrial processes. We performed a transcriptome analysis to identify genes differentially expressed in L. johnsonii N6.2 cells collected from cultures grown under different aeration conditions. Herein we described the biochemical characteristics of a heterodimeric FMN reductase (FRedA/B) whose in vitro activity is controlled by LjPAS protein with a typical Per-Arnst-Sim (PAS) sensor domain. Interestingly, LjPAS is fused to the FMN reductase domains in other lactobacillaceae. In L. johnsonii, LjPAS is encoded by an independent gene which expression is repressed under anaerobic conditions (>3 fold). Purified LjPAS was able to slow down the FRedA/B initial activity rate when the holoenzyme precursors (FredA, FredB, and FMN) were mixed in vitro. Altogether the results obtained suggest that LjPAS module regulates the H2O2 production helping the cells to minimize oxidative stress in response to environmental conditions.

  2. Bacterial growth kinetics in ACD-A apheresis platelets: comparison of plasma and PAS III storage.

    Science.gov (United States)

    Dumont, Larry J; Wood, Tammara A; Housman, Molly; Herschel, Louise; Brantigan, Barbara; Heber, Cheryl; Houghton, Jaime

    2011-05-01

    Our objective was to determine the growth kinetics of bacteria in leukoreduced apheresis platelets (LR-AP) in a platelet (PLT) additive solution (PAS; InterSol, Fenwal, Inc.) compared to LR-AP stored in plasma. Hyperconcentrated, double-dose LR-AP were collected from healthy donors with a separator (AMICUS, Fenwal, Inc.). LR-AP were evenly divided, InterSol was added to half (65% InterSol:35% plasma [PAS]), and PLTs in autologous plasma were used for a paired control (PL). Bacteria were inoculated into each LR-AP PAS/PL pair (0.5-1.6 colony-forming units [CFUs]/mL), and bacterial growth was followed for up to 7 days. Time to the end of the lag phase, doubling times, maximum concentration (conc-max), and time to maximum concentration (time-max) were estimated. Streptococcus viridans did not grow to detectable levels in either PAS or PL units. The other bacteria had no significant overall difference in the conc-max (p = 0.47) or time-max (p = 0.7) between PL and PAS LR-AP; PL had a 0.14 hours faster doubling rate (p = 0.023); and PAS had a 4.7 hours shorter lag time (p = 0.016). We observed that five index organisms will grow in LR-AP stored in a 35%:65% ratio of plasma to InterSol where initial bacterial concentrations are 0.5 to 1.6 CFUs/mL. The more rapid initiation of log-phase growth for bacteria within a PAS storage environment resulted in a bacterial concentration up to 4 logs higher in the PAS units compared to the plasma units at 24 hours, but with no difference in the conc-max. This may present an early bacterial detection advantage for PAS-stored PLTs. © 2010 American Association of Blood Banks.

  3. Minimizing Ports During Robotic Partial Nephrectomy

    Science.gov (United States)

    Argun, Omer Burak; Tufek, Ilter; Obek, Can; Tuna, Mustafa Bilal; Keskin, Selcuk; Kural, Ali Riza

    2016-01-01

    Background and Objective: Robotic upper urinary tract surgery is in most of the cases performed utilizing a standard 5 port configuration. Fewer ports can potentially produce a less invasive operation. Taking in consideration the above we report a novel technique for robot assisted laparoscopic partial nephrectomy utilizing fewer ports and we test its feasibility and safety profile. Methods: Data on 11 robot-assisted laparoscopic partial nephrectomies performed by using our technique from February 2015 through June 2015 were retrospectively analyzed. The robotic platform used was DaVinci Xi (Intuitive Surgical, Inc., Sunnyvale, California, USA) with a 3-arm setup. The AirSeal system (SurgiQuest, Milford, Connecticut, USA) was used as a port allowing simultaneous introduction of 2 instruments for the bedside surgeon, obviating the need for an additional (fourth) robotic arm. A long suction-and-irrigation device and atraumatic grasping forceps were used. Both instruments were introduced through the trocar of the AirSeal system, making simultaneous introduction and use possible. We preferred the long suction-and-irrigation device, because it minimizes collision of the instruments. Results: Mean age and BMI of the patients were 55 ±14.6 y and 29.18 ± 6.85, respectively. Seven tumors were on the right side and 4 were on the left. The mean size of the tumors was 32.45 mm (± 11.31). Surgical time was 132.2 minutes (±37.17), with an estimated blood loss and ischemia time of 103.63 mL (±65.92) and 16.72 minutes (±9.52), respectively. One patient had postoperative bleeding that was resolved without transfusion. The median hospitalization period was 3.9 d (±0.53). Loss of intra-abdominal pressure was not observed, and pressure was stable at 10 mm Hg. Conclusion: The AirSeal System and its valveless trocar eliminated the need for an additional port placement in our series. The technique is feasible, safe, and reproducible; therefore, it may be implemented in selected

  4. Test Port for Fiber-Optic-Coupled Laser Altimeter

    Science.gov (United States)

    Ramos Izquierdo, Luis; Scott, V. Stanley; Rinis, Haris; Cavanaugh, John

    2011-01-01

    A test port designed as part of a fiber optic coupled laser altimeter receiver optical system allows for the back-illumination of the optical system for alignment verification, as well as illumination of the detector(s) for testing the receiver electronics and signal-processing algorithms. Measuring the optical alignment of a laser altimeter instrument is difficult after the instrument is fully assembled. The addition of a test port in the receiver aft-optics allows for the back-illumination of the receiver system such that its focal setting and boresight alignment can be easily verified. For a multiple-detector receiver system, the addition of the aft-optics test port offers the added advantage of being able to simultaneously test all the detectors with different signals that simulate the expected operational conditions. On a laser altimeter instrument (see figure), the aft-optics couple the light from the receiver telescope to the receiver detector(s). Incorporating a beam splitter in the aft-optics design allows for the addition of a test port to back-illuminate the receiver telescope and/or detectors. The aft-optics layout resembles a T with the detector on one leg, the receiver telescope input port on the second leg, and the test port on the third leg. The use of a custom beam splitter with 99-percent reflection, 1-percent transmission, and a mirrored roof can send the test port light to the receiver telescope leg as well as the detector leg, without unduly sacrificing the signal from the receiver telescope to the detector. The ability to test the receiver system alignment, as well as multiple detectors with different signals without the need to disassemble the instrument or connect and reconnect components, is a great advantage to the aft-optics test port. Another benefit is that the receiver telescope aperture is fully back-illuminated by the test port so the receiver telescope focal setting vs. pressure and or temperature can be accurately measured (as

  5. Digitally Controlled Linear Four-Port Network

    Directory of Open Access Journals (Sweden)

    V. Michalek

    1994-09-01

    Full Text Available The paper deals with the design of a universal linear multipart. The circuit is based on digitally controlled multiple voltage-controlled voltage sources (MVCVSs. The main advantages of this control are accuracy, invariability, and very small area requirements. The whole system is simply connected to a PC via its parallel port. This multipart can generally be used as a building block for any model of a nonlinear dynamic system, namely for the piecewise-linear (PWL model in both explicit and implicit forms.

  6. Cooperation Performance Evaluation between Seaport and Dry Port; Case of Qingdao Port and Xi'an Port

    Directory of Open Access Journals (Sweden)

    Jian Li

    2014-12-01

    Full Text Available Along with the drastic competition among ports, the strive for the vast economic hinterland and the supply of goods have become strategic problems for port operators. At the same time, port enterprises are paying more and more attention to the construction of dry ports. This article establishes the port cooperation performance evaluation index based on the balanced score card method and uses the grey relational degree method to evaluate the cooperation performance between seaports and dry ports. Finally using Qingdao port and Xi'an port as an example, and Zhengzhou port and Lanzhou port as benchmarks, the application of this evaluation method is introduced in detail. The conclusion reveals that cooperation between Qingdao port and Xi'an port has deficiencies in customer satisfaction, financial cooperation and non-market tools. Alongside this, the author proposes related issues about information management in the supply chain, competition position and the scope of hinterland. This article, combined with the related theory of supply chain and performance evaluation, puts forward a set of relatively complete cooperation performance evaluations between seaports and dry ports, which provide scientific theory support for better cooperation.

  7. How electronic health records can unmask the hidden value of PAs.

    Science.gov (United States)

    Ogunfiditimi, Folusho; Sherry, Scott P; Foote, Monica; Christie, Sarah L; Shock, Lisa P; Cawley, James; Browne, Aaron

    2017-06-01

    The Fee for Value (FFV) Task Force, a subgroup of the American Academy of PAs' Research and Strategic Initiatives Commission, has examined tools and mechanisms aimed at better clarifying the volume and value of PA work and how that work contributes to improving access to high-quality care. Establishing the value of PAs has been a challenging task for many healthcare providers. Often, PA value has been defined by their clinical productivity, without any clear direction as to what constitutes value versus productivity. The objective of this article is to unmask the value of PAs through the role of electronic health records and highlight PAs' ability to produce services that are value-oriented and quantifiably productive.

  8. ON THE MYTH OF PARENTAL ALIENATION SYNDROME (PAS AND THE DSM-5

    Directory of Open Access Journals (Sweden)

    Ramón Vilalta

    2017-09-01

    Full Text Available This paper discusses the controversy over the existence of Parental Alienation Syndrome (PAS or any other name it may be given. The negative judgements regarding PAS are diverse in nature: from criticism about the personality of the term’s creator, to the most repeated criticism that PAS does not exist in the Diagnostic and Statistical Manual of Mental Disorders DSM-5. This paper analyzes some of these criticisms in the Spanish judicial context, especially those exposed in the Guidelines of the Group of Experts on the Fight against Domestic and Gender Violence of the General Council of the Judiciary (CGPJ, published in 2016. It is argued that PAS is widely recognized by the professional and scientific community and may be described and classified in the DSM-5 as a “Parent–Child Relational Problem V61.20 (Z62.820”.

  9. WORLD PORT INDEX Nineteenth Edition

    Science.gov (United States)

    2009-01-01

    the port. FIRST PORT OF ENTRY – A port where a vessel may enter and clear foreign goods and personnel through Customs and Immigration . For vessels...01 L Y Y 9865 PUERTO COLON PM 0922N 07953W 148 26068 M CB E N N N Y N H H M Y Y 9875 BAHIA DE LAS MINAS PM 0924N 07949W 148 26066 S RN F N N N Y N J D...08358W 147 27104 V OR G N N N Y N N N N 01 M Y N 10070 BAHIA HONDA CU 2258N 08310W 147 27102 M CN P Y N N Y N L J N 01 M Y Y 10080 CABANAS CU 2300N

  10. Periodic acid-Schiff (PAS) staining of immature platelets in donors.

    Science.gov (United States)

    Pogorelov, Valery M; Beskorovainova, Victoria Ju; Chanieva, Marem I; Dyagileva, Olga A; Naumova, Iren N; Skedina, Marina A

    2012-01-01

    Glycogen in platelets (PLTs) on smears of peripheral blood of 40 donors was investigated by the periodic acid-Schiff (PAS) method. Three groups were formed. Group 1 was consisted of 21 men undergoing the donor selection procedure. Additionally, 9 first-time donors undergoing plateletpheresis (Group 2) and 10 donors who frequently underwent platelet apheresis (Group 3) were studied as a model of relative thrombocytopenia. Cell sizes were measured with the use of a Image Analyzer "ASPBC" (Russia). The training procedure and classification of PAS-blood PLTs were made on the basis of expert evaluation. In this article, we have established three facts. First, the PAS-positive PLT area was larger than that of the PAS-negative cells (9.5 ± 3.6 sq.mkm vs. 3.9 ± 1.3 sq.mkm, p PAS-positivity of PLTs was 23.1 ± 9.2%. Second, the PAS-positivity correlated (r(S) = 0.63, p PAS positivity [r(S) = 0.5 (p = 0.14) and r(S) = 0.6 (p = 0.05)] which has a tendency to increase [Group 2: median PAS 24.3% (95% CI 14.8-26.2) vs. median PAS 30% (95% CI 21.6-34.2), p = 0.05 and Group 3: median PAS 31% (95% CI 19-36.4) vs. median PAS 27.4% (95% CI 18.7-34.9), p = 0.35] and correlated negatively with the decrease in the platelet count [Group 2: r(S) = -0.7 (p = 0.21) and Group 3: r(S) = -0.5 (p = 0.14)]. Our findings support the significance of platelet evaluation by light microscopy to understand why morphologic changes of thrombocytopoiesis may be expected in thrombocytopenia due to donation of platelets.

  11. Hardware Interface Description for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio Ssystem (STRS) Radio

    Science.gov (United States)

    Shalkhauser, Mary Jo W.; Roche, Rigoberto

    2017-01-01

    The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS-compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx ML605 Virtex-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek eBox 620-110-FL) running the Ubuntu 12.4 operating system. Figure 1 shows the RIACS platform hardware. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications.The purpose of this document is to describe how to develop a new waveform using the RIACS platform and the Very High Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) FPGA wrapper code and the STRS implementation on the Axiomtek processor.

  12. Prevalence and factors determining psychoactive substance (PAS) use among Hawassa University (HU) undergraduate students, Hawassa Ethiopia.

    Science.gov (United States)

    Kassa, Andargachew; Taddesse, Fiker; Yilma, Aweke

    2014-10-07

    Use of psychoactive substances (PAS) early in school age implies drug dependence in later life. Although no studies have been conducted on undergraduate students of Hawassa University, a few studies in Ethiopia have reported that alcohol, khat, and cigarette are the commonly abused PASs among young high school/undergraduate university students. Therefore, this study was designed to establish the prevalence of and predictors for PAS use among undergraduate HU Students. An institution-based quantitative cross-sectional study using the self-administered WHO Model Core Questionnaire to collect information on use of various Psychoactive Substances (PASs) was conducted from June to July 2011. A multistage stratified sampling method was employed to select a total of 586 undergraduate HU students as study participants. Bivariate and multivariate logistic regression analysis were done to determine factors affecting PAS use. Lifetime, past 12 months, and current prevalence rate for overall PAS were 53.6%, 45.7%, and 35.5% respectively. The study depicted that in the past 12 months of the study period 40.8% used alcohol, 20.3% chewed khat, 11.9% smoked cigarettes, and 0.9% used marijuana. The prevalence of other illicit PASs such as Ecstasy, lysergic diethylamide (LSD), cocaine, crack, heroin, solvents or inhalants and un-prescribed psycho active medications was found zero percent (0%). Having family members who used PAS, peer influence, being male, and living alone during school age were found to be positively associated with overall PAS use in the past 12 months. The prevalence of PAS use among undergraduate HU students is high. Designing effective strategies to reduce PAS use should be everyone's priority.

  13. EGF increases expression and activity of PAs in preimplantation rat embryos and their implantation rate

    Directory of Open Access Journals (Sweden)

    Har-Vardi Iris

    2007-01-01

    Full Text Available Abstract Background Embryo implantation plays a major role in embryogenesis and the outcome of pregnancy. Plasminogen activators (PAs have been implicated in mammalian fertilization, early stages of development and embryo implantation. As in-vitro developing embryos resulted in lower implantation rate than those developed in-vivo we assume that a reduced PAs activity may be involved. In the present work we studied the effect of EGF on PAs activity, quantity and embryo implantation. Methods Zygotes were flushed from rat oviducts on day one of pregnancy and grown in-vitro in R1ECM supplemented with EGF (10 ng/ml and were grown up to the blastocyst stage. The control groups were grown in the same medium without EGF. The distribution and quantity of the PAs were examined using fluorescence immunohistochemistry followed by measurement of PAs activity using the chromogenic assay. Implantation rate was studied using the embryo donation model. Results PAs distribution in the embryos was the same in EGF treated and untreated embryos. Both PAs were localized in the blastocysts' trophectoderm, supporting the assumption that PAs play a role in the implantation process in rats. EGF increased the quantity of uPA at all stages studied but the 8-cell stage as compared with controls. The tissue type PA (tPA content was unaffected except the 8-cell stage, which was increased. The activity of uPA increased gradually towards the blastocyst stage and more so due to the presence of EGF. The activity of tPA did not vary with the advancing developmental stages although it was also increased by EGF. The presence of EGF during the preimplantation development doubled the rate of implantation of the treated group as compared with controls.

  14. Le potager n'est pas plus vert chez le voisin | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 sept. 2016 ... D'abord, un problème demarché, car les gens ne connaissaient pas les avantages alimentaires de ces légumes. Il y avait aussi un problème d'usage, car les gens ignoraient comment les préparer. Et, finalement, un problème d'ordre agronomique, c'est-à-dire que les agriculteurs ne savaient pas les ...

  15. Purification of the major group 1 allergen from Bahia grass pollen, Pas n 1.

    Science.gov (United States)

    Drew, Alexander C; Davies, Janet M; Dang, Thanh D; Rolland, Jennifer M; O'Hehir, Robyn E

    2011-01-01

    Group 1 grass pollen allergens are glycoproteins of the β-expansin family. They are a predominant component of pollen and are potent allergens with a high frequency of serum IgE reactivity in grass pollen-allergic patients. Bahia grass is distinct from temperate grasses and has a prolonged pollination period and wide distribution in warmer climates. Here we describe the purification of the group 1 pollen allergen, Pas n 1, from Bahia grass (Paspalum notatum), an important subtropical aeroallergen source. Pas n 1 was purified from an aqueous Bahia grass pollen extract by ammonium sulphate precipitation, hydrophobic interaction and size exclusion chromatography, and assessed by one- and two-dimensional gel electrophoresis, immunoblotting and ELISA. Pas n 1 was purified to a single 29-kDa protein band containing two dominant isoforms detected by an allergen-specific monoclonal antibody and serum IgE of a Bahia grass pollen-allergic donor. The frequency of serum IgE reactivity with purified Pas n 1 in 51 Bahia grass pollen-allergic patients was 90.6%. Serum IgE reactivity with purified Pas n 1 was highly correlated with serum IgE reactivity with Bahia grass pollen extract and recombinant Pas n 1 (r = 0.821 and 0.913, respectively). Pas n 1 is a major allergen reactive at high frequency with serum IgE of Bahia grass pollen-allergic patients. Purified natural Pas n 1 has utility for improved specific diagnosis and immunotherapy for Bahia grass pollen allergy. Copyright © 2010 S. Karger AG, Basel.

  16. Robustness and evolvability in the functional anatomy of a PER-ARNT-SIM (PAS) domain.

    Science.gov (United States)

    Philip, Andrew F; Kumauchi, Masato; Hoff, Wouter D

    2010-10-19

    The robustness of proteins against point mutations implies that only a small subset of residues determines functional properties. We test this prediction using photoactive yellow protein (PYP), a 125-residue prototype of the PER-ARNT-SIM (PAS) domain superfamily of signaling proteins. PAS domains are defined by a small number of conserved residues of unknown function. We report high-throughput biophysical measurements on a complete Ala scan set of purified PYP mutants. The dataset of 1,193 values on active site properties, functional kinetics, stability, and production level reveals that 124 mutants retain the characteristic photocycle of PYP, but that the majority of substitutions significantly alter functional properties. Only 35% of substitutions that strongly affect function are located at the active site. Unexpectedly, most PAS-conserved residues are required for maintaining protein production. PAS domain activation often involves conformational changes in α-helices linked to the PAS core. However, the mechanism of transmission and kinetic regulation of allosteric structural changes from the PAS domain to these helices is not clear. The Ala scan data reveal interactions governing allosteric switching in PYP. The photocycle kinetics is significantly altered by substitutions at 58 positions and spans a 3,000-fold range. Nine residues that dock the N-terminal α-helices of PYP to its PAS core regulate signaling kinetics. Ile39 and Asn43 are identified as part of a mechanism for regulating allosteric switching that is conserved among PAS domains. These results show that PYP combines robustness with a high degree of evolvability and imply production level as an important factor in protein evolution.

  17. PAS-cal: a generic recombinant peptide calibration standard for mass spectrometry.

    Science.gov (United States)

    Breibeck, Joscha; Serafin, Adam; Reichert, Andreas; Maier, Stefan; Küster, Bernhard; Skerra, Arne

    2014-08-01

    We describe the design, preparation, and mass-spectrometric characterization of a new recombinant peptide calibration standard with uniform biophysical and ionization characteristics for mass spectrometry. "PAS-cal" is an artificial polypeptide concatamer of peptide cassettes with varying lengths, each composed of the three small, chemically stable amino acids Pro, Ala, and Ser, which are interspersed by Arg residues to allow site-specific cleavage with trypsin. PAS-cal is expressed at high yields in Escherichia coli as a Small Ubiquitin-like MOdifier (SUMO) fusion protein, which is easily purified and allows isolation of the PAS-cal moiety after SUMO protease cleavage. Upon subsequent in situ treatment with trypsin, the PAS-cal polypeptide yields a set of four defined homogeneous peptides in the range from 2 to 8 kDa with equal mass spacing. ESI-MS analysis revealed a conveniently interpretable raw spectrum, which after deconvolution resulted in a very simple pattern of four peaks with similar ionization signals. MALDI-MS analysis of a PAS-cal peptide mixture comprising both the intact polypeptide and its tryptic fragments revealed not only the four standard peptides but also the singly and doubly charged states of the intact concatamer as well as di- and trimeric adduct ion species between the peptides, thus augmenting the observable m/z range. The advantageous properties of PAS-cal are most likely a result of the strongly hydrophilic and conformationally disordered PEG-like properties of the PAS sequences. Therefore, PAS-cal offers an inexpensive and versatile recombinant peptide calibration standard for mass spectrometry in protein/peptide bioanalytics and proteomics research, the composition of which may be further adapted to fit individual needs.

  18. Effectively reducing emissions from ports

    Energy Technology Data Exchange (ETDEWEB)

    Fazlagic, Ismir; Martelin, Marcus; Skinner, Ryan

    2010-09-15

    Commercial ships calling at more and more ports worldwide can now turn off their diesel engines and tap into cleaner energy sources provided by electrical connections from shore. The technology to make this possible has been in place for over a decade. With a global technology standard due to be ratified by three technical bodies in 2010, high-voltage shore connections will soon get much more attention. Environmentally-minded ports, governments and shipowners are all tuning in to the benefits of supplying electricity to ships at berth. ABB presents the challenge, the technical solution and the business case for all parties involved.

  19. L'interface entre terre et mer. Une plateforme de transport au port du Pirée, Athènes (Grèce)

    OpenAIRE

    Beck, Anna-Lisa; Lovey, Romain

    2008-01-01

    Le port du Pirée est aujourd'hui le plus grand port passager de la Méditerranée ainsi qu'une porte d'entrée majeure pour la ville d'Athènes (20 millions de passagers par année). Lieu de convergence de nombreux réseaux de transports terrestres et maritimes, le port ne possède pas d'infrastructures adaptées, connectant ces divers réseaux. Il en résulte une congestion permanente qui paralyse son fonctionnement. Une augmentation continue du nombre de passagers a poussé les autorités à restructure...

  20. Les scientifiques du CERN n'oublient pas l'Irak pour eux, les préoccupations humanitaires n'ont pas de passeport

    CERN Multimedia

    2003-01-01

    Scientists from the CERN club ConCERNed for Humanity have written to the Swiss Federal Councellor, Micheline Calmy-Rey, with 550 signatures on a petition "pas en notre nom" - not in our name - to ask her to do all that is in her capacity to end the conflict in Iraq (0.5 page)

  1. The VisPort Project: Visualization of Port Logistics

    Science.gov (United States)

    Katsioloudis, Petros J.; Watson, Ginger

    2011-01-01

    There is concern about the diminishing availability of skilled personnel that can operate in the wide variety of disciplines associated with port operations. Increasing cargo volume, combined with a shrinking workforce, could potentially create alarming situations in the future, hence the motivation to publicize to current students the breadth and…

  2. Colorectal carcinoma in Port Harcourt | Adotey | Port Harcourt ...

    African Journals Online (AJOL)

    Colorectal carcinoma in Port Harcourt. ... Methodology: Patients treated for colorectal cancer at the UPTH over a 19- year period (1987-2006) and had complete information, were studied. Data were collected ... Other indices studied were treatment, postoperative complications, duration of hospital stay and outcome/mortality.

  3. Port Harcourt Medical Journal, a paradigm shift | Eke | Port Harcourt ...

    African Journals Online (AJOL)

    Port Harcourt Medical Journal, a paradigm shift. N Eke. Abstract. No Abstract. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4103/0795-3038.179439 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

  4. Homodimerization of the PAS-B domains of hypoxia-inducible factors.

    Science.gov (United States)

    Zhu, Jing; Martinez-Yamout, Maria; Cardoso, Rosa; Yan, Jiangli; Love, Robert A; Grodsky, Neil; Brooun, Alexei; Dyson, H Jane

    2012-06-14

    The Per-Arnt-Sim (PAS) domains of hypoxia-inducible transcription factors (HIF) mediate heterodimer formation between the HIF-α forms that are induced in the event of cellular hypoxia and the constitutive HIF-β variants. Previous efforts toward structural characterization of the HIF-1α PAS domains were limited by protein stability. Using homology modeling based on the published crystal structure of the PAS-B domain of the homologous protein HIF-2α in complex with the partner HIF-β (also known as ARNT), we have identified a variant of HIF-1α with improved solubility, monodispersity, and stability. Purified solutions of the PAS-B domains of HIF-1α and HIF-2α differ in their propensity for homodimer formation. In an attempt to understand the structural basis for this difference, and to document the structural changes that accompany homodimer formation, we have undertaken a comparative NMR study of the PAS-B domains of HIF-1α and HIF-2α and mutants of HIF-1α that mimic the behavior of HIF-2α. The NMR spectra of all of these domains are very similar, consistent with the similarity of their amino acid sequences. However, the greater propensity of the HIF-1α PAS-B domain to form dimers as the concentration was increased allowed us to determine the site of homodimerization and pointed toward possible sequence changes in HIF-1α that might discourage the formation of homodimers.

  5. Development of Sea Port in Gdynia

    Directory of Open Access Journals (Sweden)

    Palmowski Tadeusz

    2016-09-01

    Full Text Available Seaports operate on a highly competitive global transport market. To retain its competitive position a port (terminal must strengthen its competitive advantages in all fields of activity. Ports are to expand and modernize their infrastructure and superstructure, and develop links with the hinterland and the foreland. The article describes how the port of Gdynia manages to meet these challenges. The author analyses the period 2007—2015. Special attention is paid to the port development plan for 2020. The EU Structural Funds has provided a good opportunity to strengthen the competitive position of the port by making investments in the port infrastructure and superstructure. It allowed the port to strengthen its links with the hinterland. The author uses a set of fundamental, analytical and technical research methods to analyse materials provided by the port authority and the port terminal operators. By the end of 2015, the port authority had completed five investment projects, including the modernization of th ree wharfs and a rail terminal, the development of the port infrastructure aimed to provide services to ro-ro ships. Strategically important projects for the coming years include dredging and widening of the port channel, fairways and the internal basin. Cooperation between the port and the city authorities allowed the port administration to improve road access to the port of Gdynia. The key investment project aims to link the port of Gdynia to the TriCity ring road. Apart from it, there are plans to improve access to the railroad network. Railway line 201 to Bydgoszcz is to be modernised to transport cargoes from Gdynia further inland. The current and future strategic investments create conditions for growth in handling both container and other types of cargo in the port of Gdynia and significantly improve competitiveness of the maritime sector.

  6. Genome-wide survey and expression analysis of the bHLH-PAS genes in the amphioxus Branchiostoma floridae reveal both conserved and diverged expression patterns between cephalochordates and vertebrates.

    Science.gov (United States)

    Li, Kun-Lung; Lu, Tsai-Ming; Yu, Jr-Kai

    2014-01-01

    The bHLH-PAS transcription factors are found in both protostomes and deuterostomes. They are involved in many developmental and physiological processes, including regional differentiation of the central nervous system, tube-formation, hypoxia signaling, aromatic hydrocarbon sensing, and circadian rhythm regulation. To understand the evolution of these genes in chordates, we analyzed the bHLH-PAS genes of the basal chordate amphioxus (Branchiostoma floridae). From the amphioxus draft genome database, we identified ten bHLH-PAS genes, nine of which could be assigned to known orthologous families. The tenth bHLH-PAS gene could not be assigned confidently to any known bHLH family; however, phylogenetic analysis clustered this gene with arthropod Met family genes and two spiralian bHLH-PAS-containing sequences, suggesting that they may share the same ancestry. We examined temporal and spatial expression patterns of these bHLH-PAS genes in developing amphioxus embryos. We found that BfArnt, BfNcoa, BfSim, and BfHifα were expressed in the central nervous system in patterns similar to those of their vertebrate homologs, suggesting that their functions may be conserved. By contrast, the amphioxus BfAhr and BfNpas4 had expression patterns distinct from those in vertebrates. These results imply that there were changes in gene regulation after the divergence of cephalochordates and vertebrates. We have identified ten bHLH-PAS genes from the amphioxus genome and determined the embryonic expression profiles for these genes. In addition to the nine currently recognized bHLH-PAS families, our survey suggests that the BfbHLHPAS-orphan gene along with arthropod Met genes and the newly identified spiralian bHLH-PAS-containing sequences represent an ancient group of genes that were lost in the vertebrate lineage. In a comparison with the expression patterns of the vertebrate bHLH-PAS paralogs, which are the result of whole-genome duplication, we found that although several members

  7. Introduction to the Delaware River Port Authority's Smart Bridges initiative

    Science.gov (United States)

    Box, Robert A.; McCullough, Patrick J.; Bistline, Robert S.

    2000-06-01

    The Delaware River Port Authority, whose mission is to manage, plan and construct transportation facilities and provide transportation services to maximize the safe and efficient movement of people and freight within the Delaware River Valley, located in southwestern Pennsylvania and southern New Jersey, is a self-financing, bi-state Authority, formed by a compact between the Commonwealth of Pennsylvania and the State of New Jersey and approved by the Congress of the United States. The Delaware River Port Authority is firmly committed to the strategic and integrated use of advanced transportation technology to improve traffic flow, operational efficiency and safety on DRPA's four bridges. To this end, the Delaware River Port Authority has initiated a program, appropriately named 'Smart Bridges.' The Delaware River Port Authority has recognized that this type of program is essential to the advancement of the DRPA's mission as an efficient, customer- friendly transportation and regional development agency. Under the Smart Bridges program the Delaware River Port Authority is introducing new technology into its aging infrastructure and transportation systems to ensure that the facilities continue to serve the region into the 21st century and beyond. Initiatives introduced under this program include EZ Pass, video surveillance systems, computerized traffic control systems and partnering with local universities to investigate the application of various innovative technologies to assist in the maintenance of the bridge facilities.

  8. Les sciences cognitives ne sont pas des sciences humaines

    Directory of Open Access Journals (Sweden)

    Albert Ogien

    2011-10-01

    Full Text Available Cet article analyse les limites du naturalisme social que Laurence Kaufman et Laurent Cordonier proposent d’adopter dans cette même revue, en critiquant leur plaidoyer pour l’intégration des savoirs des sciences cognitives et des sciences humaines et sociales. Cette critique repose sur la réfutation de trois idées soutenues par les auteurs : 1 la description scientifique des mécanismes cognitifs élémentaires fournit une explication causale des conduites sociales qui doit se substituer à celles des sciences humaines et sociales ; 2 le recours au naturalisme permet de falsifier les préconceptions que ces dernières continuent à entretenir ; 3 le programme de naturalisation de l’esprit n’implique aucune forme de réductionnisme. Cette triple critique permet de rejeter leur appel en faveur d’un modèle intégré de la conduite humaine, en avançant un constat : dans la mesure où on ne sait pas comment combler le hiatus qui sépare les descriptions détaillées du cerveau au travail de l’explication des conduites des individus et de la manière dont ils en assurent la coordination dans le temps même où ils agissent en commun, les sciences humaines et sociales ont peu de choses à aller glaner du côté des sciences cognitives pour améliorer la manière dont elles analysent l’action. C’est que le travail de celles-ci se situe soit au niveau infra-humain du fonctionnement moléculaire, soit au niveau supra-humain de l’évolution ; et que seules les sciences humaines et sociales placent leurs analyses à un niveau simplement humain, en faisant des individus tels qu’ils vivent ensemble la mesure de toutes les choses qui les concernent. Ce qu’elles ne peuvent faire sur un mode naturaliste.Cognitive sciences are not social sciencesThis article examines the limits of the social naturalism proposed by Laurence Kauffman and Laurent Cordonier in this journal by criticizing their plea concerning knowledge integration of

  9. MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.

    Science.gov (United States)

    Sullivan, Adrienne E; Peet, Daniel J; Whitelaw, Murray L

    2016-09-01

    Transcription factors of the basic helix-loop-helix (bHLH) PER-ARNT-SIM (PAS) family generally have critical and nonredundant biological roles, but some bHLH PAS proteins compete for common cofactors or recognise similar DNA elements. Identifying factors that regulate function of bHLH PAS proteins, particularly in cells where multiple family members are coexpressed, is important for understanding bHLH PAS factor biology. This study identifies and characterises a novel interaction between melanoma-associated antigen D1 (MAGED1) and select members of the bHLH PAS transcription factor family. MAGED1 binds and positively regulates the transcriptional activity of family members SIM1, SIM2, NPAS4 and ARNT2, but does not interact with AhR, HIF1α and ARNT. This interaction is mediated by PAS repeat regions which also form the interface for bHLH PAS dimerisation, and accordingly MAGED1 is not found in complex with bHLH PAS dimers. We show that MAGED1 does not affect bHLH PAS protein levels and cannot be acting as a coactivator of transcriptionally active heterodimers, but rather appears to interact with nascent bHLH PAS proteins in the cytoplasm to enhance their function prior to nuclear import. As a selective regulator, MAGED1 may play an important role in the biology of these specific factors and in general bHLH PAS protein dynamics. © 2016 Federation of European Biochemical Societies.

  10. Single port Billroth I gastrectomy

    Directory of Open Access Journals (Sweden)

    Jeremy R Huddy

    2013-01-01

    Full Text Available Introduction: Experience has allowed increasingly complex procedures to be undertaken by single port surgery. We describe a technique for single port Billroth I gastrectomy with a hand-sewn intracorporeal anastomosis in the resection of a benign tumour diagnosed incidentally on a background of cholelithiasis. Materials and Methods: Single port Billroth I gastrectomy and cholecystectomy was performed using a transumbilical quadport. Flexible tipped camera and straight conventional instruments were used throughout the procedure. The stomach was mobilised including a limited lymph node dissection and resection margins in the proximal antrum and duodenum were divided with a flexible tipped laparoscopic stapler. The lesser curve was reconstructed and an intracorporal hand sewn two layer end-to-end anastomosis was performed using unidirectional barbed sutures. Intraoperative endoscopy confirmed the anastomosis to be patent without leak. Results: Enteral feed was started on the day of surgery, increasing to a full diet by day 6. Analgesic requirements were a patient-controlled analgesia morphine pump for 4 postoperative days and paracetamol for 6 days. There were no postoperative complications and the patient was discharged on the eighth day. Histology confirmed gastric submucosal lipoma. Discussion: As technology improves more complex procedures are possible by single port laparoscopic surgery. In this case, flexible tipped cameras and unidirectional barbed sutures have facilitated an intracorporal hand-sewn two layer end-to-end anastomosis. Experience will allow such techniques to become mainstream.

  11. Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes.

    Science.gov (United States)

    Upadhyay, Amit A; Fleetwood, Aaron D; Adebali, Ogun; Finn, Robert D; Zhulin, Igor B

    2016-04-01

    Cellular receptors usually contain a designated sensory domain that recognizes the signal. Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from bacteria to humans. Although PAS domains were described as intracellular sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several transmembrane receptors. However, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domain models, and thus their distribution across the genomic landscape remains largely unknown. Here we show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which is homologous to, but distinct from the PAS superfamily. Our newly built computational models enabled identification of Cache domains in tens of thousands of signal transduction proteins including those from important pathogens and model organisms. Furthermore, we show that Cache domains comprise the dominant mode of extracellular sensing in prokaryotes.

  12. Shear-mediated platelet activation in patients implanted with continuous flow LVADs: A preliminary study utilizing the platelet activity state (PAS) assay.

    Science.gov (United States)

    Valerio, Lorenzo; Consolo, Filippo; Bluestein, Danny; Tran, Phat; Slepian, Marvin; Redaelli, Alberto; Pappalardo, Federico

    2015-08-01

    Left ventricular assist devices (LVADs) have emerged as vital life-saving therapeutic systems for patients with advanced and end-stage heart failure (HF). Despite their efficacy, VAD systems remain limited by post-implantation thrombotic complications. Shear-mediated platelet activation is the major driver of such complications in these devices. Nowadays few platelet function assays are routinely utilized in assessing the degree of platelet activation in VAD implanted patients. No assays exist that specifically target shear-mediated platelet activation. The platelet activity state (PAS) is a novel assay that has been well validated in vitro, measuring thrombin release as a surrogate for shear-mediated platelet activation. To date limited data exist as to the utility of this assay in the clinical setting. In the present study we evaluated eight LVAD patients' platelet activation level using the PAS assay. Simultaneous measurements of conventional prothrombotic and hemolysis markers, - i.e. fibrinogen and lactate dehydrogenase (LDH) - were also performed. Trends as to alteration from baseline were studied. We observed that the PAS assay allowed detection of an abnormal level of platelet activation in one patient in our series who suffered from an overt thrombosis. Interestingly in the same patient no signal of major abnormality in fibrinogen or LDH was detected. Further for 7/8 patients who were free of thrombosis, no significant level of platelet activation was detected via PAS assay, while elevation in fibrinogen and LDH were observed. As such, from our observational series it appears that the PAS assay is a sensitive and specific indicator of shear-mediated platelet activation. Further patients' experience will help elucidate the role of this promising assay in the management of LVAD implanted patients.

  13. Knowledge Discovery of Port Scans from Darknet

    OpenAIRE

    Lagraa, Sofiane; Francois, Jerome

    2017-01-01

    International audience; Port scanning is widely used in Internet prior for attacks in order to identify accessible and potentially vulnerable hosts. In this work, we propose an approach that allows to discover port scanning behavior patterns and group properties of port scans. This approach is based on graph modelling and graph mining. It provides to security analysts relevant information of what services are jointly targeted, and the relationship of the scanned ports. This is helpful to asse...

  14. Improving the competitiveness of the Spanish port system by optimizing the cargo service; Mejora de la competitividad del Sistema Portuario Espanol mediante la optimizacion del servicio de manipulacion de mercancias

    Energy Technology Data Exchange (ETDEWEB)

    Almazan Garate, J. L.; Parra Serrano, M. P.

    2012-07-01

    Port services are responsible for most of the cost for the passing of goods through the port, especially the cargo handling service. Reliability and efficiency in the provision of them are key in a sector where there is a high opacity. With this study, we provide the responsible Administration, the Port Authority, with a tool that will help to objectify the decision making process, both at the time of granting the required licenses and during the period of the service provision. Also, proposes a number of measures w hoses implementation would improve the conditions of the service delivery and will reduce the total cost of transporting goods through the port. (Author) 11 refs.

  15. Coal handling in Indian port - an infrastructure audit

    Energy Technology Data Exchange (ETDEWEB)

    Mishra, P. [Canopus Shipping and Trading Pvt Ltd. (India)

    2003-07-01

    Seventeen slides/overheads illustrate the content of the talk about India's ports, port tariffs, forecast growth in coal handling, plans for increased capacity of ports, discharge equipment employed, and port cost structure.

  16. Multi-port isolated LLC resonant converter for distributed energy generation with energy storage

    DEFF Research Database (Denmark)

    Tomas Manez, Kevin; Zhang, Zhe; Ouyang, Ziwei

    2017-01-01

    Distributed energy generation systems with energy storage and microgrids have attracted increasing research interest in recent years. Therefore, multi-ports dc-dc converters have gained more interest. However, when integrating into multiple port converters, the power flow control and ports...... regulation increase in complexity. In this paper, an isolated multi-port bidirectional converter based on an LLC converter is presented. The converter operates as a dc transformer at a fixed switching frequency and duty cycle without any control loop. The resonant tanks are designed to ensure soft...

  17. Information Support to Transport-Logi stic Infrastructure in the Port of Koper

    Directory of Open Access Journals (Sweden)

    Boris Marzi

    2012-10-01

    Full Text Available Besides the trade flow, the Port of Koper, as an organisationalfonn of co-operation between parties offering transportservices, needs also the infonnation flow in the area it covers.The article shows the possibility of graphic presentation ofthe Port transport and logistic infrastructure and the graphiccommunication between all the users of the Port area. The intranetconnection gives every user the insight into the systemwhere all the requested data for an efficient exploitation of a detenninedinfrastructure are available.The possibility of applying the intranet connections in thewhole operating system of the enterprise offering port services isillustrated in the conclusion.

  18. Ports and Terminals : Planning and Functional Design

    NARCIS (Netherlands)

    Groenveld, R.; Velsink, H.

    1993-01-01

    1. Maritime transport, means and commodities 3. Principles of integrated port planning 4. Planning and design of a port's water areas 5. Port terminals - introduction 6. Conventional general cargo terminals 7. Container terminals 8. Oil & liquid gas terminals 9. Dry bulk cargo terminals 10. Fishery

  19. Multi-functional use of port areas

    NARCIS (Netherlands)

    Ros, R.; Taneja, P.; Vellinga, T.

    2012-01-01

    The core business of a port is handling vessels and cargo. In addition a landlord Port Authority invests in development of port areas. However, in view of the new trends such as stakeholders interests related to environment and sustainability, it is can be wise to reexamine the business portfolio

  20. PAS: um perfil neoliberal de gestão de sistema público de saúde

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo Elias

    1999-04-01

    Full Text Available NO PRESENTE artigo trata-se de analisar o Plano de Assistência à Saúde da Prefeitura do Município de São Paulo na perspectiva da gestão dos sistemas de saúde e da preservação dos direitos sociais. Apresenta-se uma breve retrospectiva da construção da saúde enquanto um direito social nas sociedades contemporâneas e traça-se o quadro das políticas de saúde no Brasil, em anos recentes, enfatizando seu processo de descentralização para a esfera municipal. Examina-se o PAS como alternativa de gestão e conclui-se pela incapacidade da sua regulação pelas forças de mercado e a sua inconsistência ideológica frente aos preceitos liberais para o setor saúde. Encerra-se com um breve balanço dos legados proporcionados por essa experiência de gestão.IN THIS ARTICLE is analysed the Health Care Plan (Plano de Assistencia à Saúde - PAS of the municipality of São Paulo from the perspective of the health system management and of preservation of social rights. It is presented a brief historical retrospective of the construction of health as a social right in contemporary societies, and a picture of health policies in Brazil in recent years emphasizing its decentralization process towards the municipal level. It is also examined the PAS as a management alternative and it is concluded that market forces are unable to regulate it and that it has ideological inconsistencies when faced to the liberal principles in force in the health sector. The author finishes the article with a brief balance of the legacy provided by this management experience.

  1. The Parkinson Anxiety Scale (PAS): development and validation of a new anxiety scale.

    Science.gov (United States)

    Leentjens, Albert F G; Dujardin, Kathy; Pontone, Gregory M; Starkstein, Sergio E; Weintraub, Daniel; Martinez-Martin, Pablo

    2014-07-01

    Existing anxiety rating scales have limited construct validity in patients with Parkinson's disease (PD). This study was undertaken to develop and validate a new anxiety rating scale, the Parkinson Anxiety Scale (PAS), that would overcome the limitations of existing scales. The general structure of the PAS was based on the outcome of a Delphi procedure. Item selection was based on a canonical correlation analysis and a Rasch analysis of items of the Hamilton Anxiety Rating Scale (HARS) and the Beck Anxiety Inventory (BAI) from a previously published study. Validation was done in a cross-sectional international multicenter study involving 362 patients with idiopathic PD. Patients underwent a single screening session in which the PAS was administered, along with the Hamilton Depression Rating Scale, the HARS, and the BAI. The Mini International Neuropsychiatric Interview was administered to establish Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnoses of anxiety and depressive disorders. The PAS is a 12-item observer or patient-rated scale with three subscales, for persistent, episodic anxiety and avoidance behavior. Properties for acceptability and reliability met predetermined criteria. The convergent and known groups validity was good. The scale has a satisfactory factorial structure. The area under the receiver operating characteristics curve and Youden index of the PAS are higher than that of existing anxiety rating scales. The PAS is a reliable and valid anxiety measure for use in PD patients. It is easy and brief to administer, and has better clinimetric properties than existing anxiety rating scales. The sensitivity to change of the PAS remains to be assessed. © 2014 International Parkinson and Movement Disorder Society.

  2. Evaluating the PAS-SIM model using a passive air sampler calibration study for pesticides.

    Science.gov (United States)

    Restrepo, Andrés Ramírez; Hayward, Stephen J; Armitage, James M; Wania, Frank

    2015-07-01

    The main objective of this study was to evaluate the performance of a model for simulating the uptake of various pesticides on passive air samplers (PAS). From 2006-2007 a series of PAS using XAD-resin were deployed at Egbert, a rural agricultural site in southern Ontario, Canada, to measure the uptake of pesticides for time periods ranging from two months to one year. A continuous increase in sequestered amounts was observed for most pesticides, except for trifluralin and pendimethalin, which could conceivably be subject to substantial degradation inside the sampler. Continuous low-volume active air samples taken during the same period, along with data on weather conditions, allowed for the simulation of the uptake of the pesticides using the model (PAS-SIM). The modelled accumulation of pesticides on the PAS over the deployment period was in good agreement with the experimental data in most cases (i.e., within a factor of two) providing insight into the uptake kinetics of this type of sampler in the field. Passive sampling rates (PSR, m(3) d(-1)) were determined from the empirical data generated for this study using three different methods and compared with the PSRs generated by the model. Overall, the PAS-SIM model, which is capable of accounting for the influence of temperature and wind variations on PSRs, provided reasonable results that range between the three empirical approaches employed and well-established literature values. Further evaluation and application of the PAS-SIM model to explore the potential spatial and temporal variability in PAS uptake kinetics is warranted, particularly for established monitoring sites where detailed meteorological data are more likely to be available.

  3. Review of Long Wave Dynamics over Reefs and into Ports with Implication for Port Operations

    Directory of Open Access Journals (Sweden)

    Ap van Dongeren

    2016-02-01

    Full Text Available This paper reviews the dynamics of infragravity (long-period waves over reef systems and the consequences of these waves for operations in ports located behind reefs with particular attention to Western Australia. Swells which originate in the Southern Ocean generate long (infragravity waves, which propagate to the coast. On the reef edge, the swell waves are largely dissipated, transferring energy to turbulence and heat but also in that process generating long wave energy. The remaining swell waves are dominated by the infragravity waves and propagate towards the mainland and into port basins where they cause moored ship motions with consequences for the operational downtime of the port’s operations. When contemplating solutions to mitigate the impact of the long wave problems, these may be addressed from two sides: from the load side (waves and the strength side (mooring. The former will be discussed in this paper.

  4. An overview of San Francisco Bay PORTS

    Science.gov (United States)

    Cheng, Ralph T.; McKinnie, David; English, Chad; Smith, Richard E.

    1998-01-01

    The Physical Oceanographic Real-Time System (PORTS) provides observations of tides, tidal currents, and meteorological conditions in real-time. The San Francisco Bay PORTS (SFPORTS) is a decision support system to facilitate safe and efficient maritime commerce. In addition to real-time observations, SFPORTS includes a nowcast numerical model forming a San Francisco Bay marine nowcast system. SFPORTS data and nowcast numerical model results are made available to users through the World Wide Web (WWW). A brief overview of SFPORTS is presented, from the data flow originated at instrument sensors to final results delivered to end users on the WWW. A user-friendly interface for SFPORTS has been designed and implemented. Appropriate field data analysis, nowcast procedures, design and generation of graphics for WWW display of field data and nowcast results are presented and discussed. Furthermore, SFPORTS is designed to support hazardous materials spill prevention and response, and to serve as resources to scientists studying the health of San Francisco Bay ecosystem. The success (or failure) of the SFPORTS to serve the intended user community is determined by the effectiveness of the user interface.

  5. Pulse Response Measurement and Processing by Six-Port Reflectometr

    Directory of Open Access Journals (Sweden)

    Norbert Majer

    2008-01-01

    Full Text Available In this paper the pulse response estimation of radio channel by Six-port reflectometer (SPR is described. The measurement of pulse response is in real time, with baseband conversion and without demodulation. This system is simple, small, exact and inexpensive. In the present, it is insisted on signal processing in real time. In present time it is requested touse faster systems of signal processing, so the using of high performance digital devices is needed. Pulse response of radio channel, six-port reflectometer and radio channel are simulated in program language Delphi 7. In this work the pulse response measurement of MIMO radio channel by Six-port reflectometer technique. A pulse response matrix, Rayleighfading in the radio channel, SPR technology, AWGN radio channel has been simulated in program language Delphi 7.

  6. HFB : A FASTBUS multi event double port buffer memory

    Energy Technology Data Exchange (ETDEWEB)

    Cerrito, L.; Lebbolo, H.

    1986-02-01

    The authors describe here the FB double port buffer memory developed at the LPNHE of the University Paris VI. Its purposes are to make available same features useful in the High Energy environment, to reduce, for a given amount of memory, the dead time data collection in a large size (in term of read-out channels) High Energy experiment and to get a buffer of memory as cheap and reliable as possible. The FB protocol, on the crate and cable side, is exploited using the coupler on 4 PAL's developed by G.Fremont and E.Sanchis. The DATA-Space is divided in 4 independent smaller blocks in a way such that a block can be accessed from a port while a different block is accessed from the other port. The two ports are: A, the FB crate port and B, the FB cable port. The buffer works as a rotary FIFO, looping over the 4 blocks of memory, but allowing for any random access. A mechanism is implemented on the board in order to be able to link different modules placed everywhere. If there are m modules, the looping will be around m 4 memory blocks. A multi event function is implemented on the board. HFB is quiped of two NTA for the DATA-Space on the port ''A'', and a flag to choose between them, to allow for a FB spying of DATA during the DAS dead time. HFB is a buffer of memory which can be used at each stage of a DAS: Frontend, Intermediate (MEB) or final, being completely FB standard. The HFB was designed for the LEP data acquisition system.

  7. Port Efficiency and International Trade: Port Efficiency as a Determinant of Maritime Transport Costs

    OpenAIRE

    Sánchez, Ricardo J.; Jan Hoffmann; Alejandro Micco; Georgina V Pizzolitto; Martín Sgut; Gordon Wilmsmeier

    2003-01-01

    This paper examines the determinants of waterborne transport costs, with particular emphasis on the efficiency at port level. Its main contribution is (1) to generate statistically quantifiable measures of port efficiency from a survey of Latin American common user ports, and (2) to estimate a model of waterborne transport costs, including the previously generated port efficiency measures as explanatory variables. In order to incorporate different port efficiency measures from the survey, we ...

  8. Sustainable port infrastructure, practical implementation of the green port concept

    Directory of Open Access Journals (Sweden)

    Pavlic Bostjan

    2014-01-01

    Full Text Available The overall idea and research interest related with the development of sustainable port infrastructure evolved around the core requirements of continuous reduction of negative environmental impacts without jeopardising economic growth. The growth of trade activities and need for competitiveness on the global market are forcing ports around the world to systematically and continuously evaluate all possibilities for the optimisation and related costs reduction. On the implementation level, the greatest challenge is how to empower workers, who operate machines and work on the shop floor, to achieve enduring performance improvements. Presented research work provides a methodological approach for finding realistic solutions to the problem of the future development challenges of seaports. The case study shown in this research represents a practical application of the green port concept with the emphasis on the overall energy efficiency improvement based on testing, deployment and demonstration of energy efficient solutions. Additional emphasis was placed on the state-of-the-art technologies and developing pilot initiatives based on modern energy solutions designed to improve efficiency in fuel consumption and emissions reduction in rubber tired gantry cranes.

  9. Jean Lesaulnier, Images de Port-Royal

    OpenAIRE

    Pavesio, Monica

    2017-01-01

    Il volume di Jean Lesaulnier completa e precisa il precedente, pubblicato nel 2002 con il titolo di Images de Port-Royal I, che ha inaugurato la collezione Univers Port-Royal delle edizioni Classiques Garnier. Seguendo l’esempio del primo tomo, il presente saggio è suddiviso in tre sezioni che raggruppano venticinque studi: «Autour de Port-Royal des Champs» (cap. I-XI), «Questions d’historiographie port-royaliste» (cap. XII-XVII), «Figures discrètes de Port-Royal» (cap. XVIII-XXIV), con in ag...

  10. Hub Status and Indexation of Container Ports

    Directory of Open Access Journals (Sweden)

    Yong-An Park

    2015-06-01

    This study develops two sub-indexes of port classification and capacity, and combines cases of these two sub-indexes into various types in order to find a proper port hub index. The paper demonstrates how different types of port hub index are useful measurements for evaluating outputs and inputs of container ports. In a case analysis we show that the indexes of period variables and lagged variables have more explanatory power with regard to changes of port throughputs and high correlation with inputs.

  11. Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor PAS-A Domain

    Science.gov (United States)

    Wu, Dalei; Potluri, Nalini; Kim, Youngchang

    2013-01-01

    The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to xenobiotics and responds by regulating the expression of gene programs required for detoxification and metabolism. AHR and its heterodimerization partner aryl hydrocarbon receptor nuclear translocator (ARNT) belong to the basic helix-loop-helix (bHLH)–PER-ARNT-SIM (PAS) family of transcription factors. Here we report the 2.55-Å-resolution crystal structure of the mouse AHR PAS-A domain, which represents the first AHR-derived protein structure. The AHR PAS-A domain forms a helix-swapped homodimer in the crystal and also in solution. Through a detailed mutational analysis of all interface residues, we identified several hydrophobic residues that are important for AHR dimerization and function. Our crystallographic visualization of AHR PAS-A dimerization leads us to propose a mode of heterodimerization with ARNT that is supported by both biochemical and cell-based data. Our studies also highlight the residues of other mammalian bHLH-PAS proteins that are likely involved in their homo- or heterodimerization. PMID:24001774

  12. Interactional role of microRNAs and bHLH-PAS proteins in cancer (Review).

    Science.gov (United States)

    Li, Yumin; Wei, Yucai; Guo, Jiwu; Cheng, Yusheng; He, Wenting

    2015-07-01

    MicroRNAs (miRNAs) are recognized as an emerging class of master regulators that regulate human gene expression at the post-transcriptional level and are involved in many normal and pathological cellular processes. Mammalian basic HLH (helix-loop-helix)-PER-ARNT-SIM (bHLH-PAS) proteins are heterodimeric transcriptional regulators that sense and respond to environmental signals (such as chemical pollutants) or to physiological signals (for instance hypoxia). In the normal state, bHLH-PAS proteins are responsible for multiple critical aspects of physiology to ensure the cell accurate homeostasis, but dysregulation of these proteins has been shown to contribute to carcinogenic events such as tumor initiation, promotion, and progression. Increasing epidemiological and experimental studies have shown that bHLH-PAS proteins regulate a panel of miRNAs, whereas some miRNAs also target bHLH-PAS proteins. The interaction between miRNAs and certain bHLH-PAS proteins [hypoxia-inducible factor (HIF) and aryl hydrocarbon receptor (AHR)] is relevant to many vital events associated with tumorigenesis. This review will summarize recent findings on the interesting and complicated underlying mechanisms that miRNAs interact with HIFs or AHR in tumors, hopefully to benefit the discovery of novel drug-interfering targets for cancer therapy.

  13. The National Ambulatory Medical Care Survey: PAs and NPs in outpatient surgery.

    Science.gov (United States)

    Salibian, Ara A; Mahboubi, Hossein; Patel, Madhukar S; Kuan, Edward C; Malinoski, Darren J; Vagefi, Parsia A; Djalilian, Hamid R

    2016-05-01

    This study aimed to determine the prevalence and occupational characteristics of physician assistants (PAs) and nurse practitioners (NPs) in outpatient surgical subspecialty clinics. The 2007 and 2008 National Ambulatory Medical Care Survey (NAMCS) databases were queried for the number and characteristics of office visits seen by different provider types (PAs or NPs, physicians, or both) in various surgical subspecialties. More than 250 million weighted sample visits were analyzed. PAs or NPs were involved in 5.9% of visits, though the percentage of patients seen by them alone (1.1%) was significantly lower (PPAs and NPs were more likely to be involved in pre- or postoperative visits, and often saw the same diagnoses alone as physicians only. The most common procedures performed by PAs and NPs varied according to subspecialty. PAs and NPs have a minor prevalence in the ambulatory surgical workforce during the time period studied. Further integration of these providers into the outpatient setting may help optimize efficiency in ambulatory surgical care.

  14. Open port sampling interface

    Science.gov (United States)

    Van Berkel, Gary J

    2017-04-25

    A system for sampling a sample material includes a probe which can have an outer probe housing with an open end. A liquid supply conduit within the housing has an outlet positioned to deliver liquid to the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust conduit within the housing is provided for removing liquid from the open end of the housing. A liquid exhaust system can be provided for removing liquid from the liquid exhaust conduit at a second volumetric flow rate, the first volumetric flow rate exceeding the second volumetric flow rate, wherein liquid at the open end will receive sample, liquid containing sample material will be drawn into and through the liquid exhaust conduit, and liquid will overflow from the open end.

  15. Open port sampling interface

    Energy Technology Data Exchange (ETDEWEB)

    Van Berkel, Gary J.

    2018-01-16

    A system for sampling a sample material includes a probe which can have an outer probe housing with an open end. A liquid supply conduit within the housing has an outlet positioned to deliver liquid to the open end of the housing. The liquid supply conduit can be connectable to a liquid supply for delivering liquid at a first volumetric flow rate to the open end of the housing. A liquid exhaust conduit within the housing is provided for removing liquid from the open end of the housing. A liquid exhaust system can be provided for removing liquid from the liquid exhaust conduit at a second volumetric flow rate, the first volumetric flow rate exceeding the second volumetric flow rate, wherein liquid at the open end will receive sample, liquid containing sample material will be drawn into and through the liquid exhaust conduit, and liquid will overflow from the open end.

  16. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress.

    Science.gov (United States)

    Hellhammer, J; Fries, E; Buss, C; Engert, V; Tuch, A; Rutenberg, D; Hellhammer, D

    2004-06-01

    Phosphatidylserine, derived from cow brains, has been shown previously to dampen the ACTH and cortisol response to physical stress. Further research investigated the influence of soy lecithin phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. In this study, we investigated the effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) supplementation on pituitary adrenal reactivity (ACTH, cortisol) and on the psychological response (Spielberger State Anxiety Inventory stress subscale) to a mental and emotional stressor. Four groups of 20 subjects were treated for three weeks with daily dosages of either 400 mg PAS, 600 mg PAS, 800 mg PAS, or placebo before exposure to the Trier Social Stress Test (TSST). Treatment with 400 mg PAS resulted in a pronounced blunting of both serum ACTH and cortisol, and salivary cortisol responses to the TSST, but did not affect heart rate. The effect was not seen with larger doses of PAS. With regard to the psychological response, 400 mg PAS seemed to exert a specific positive effect on emotional responses to the TSST. While the placebo group showed the expected increase in distress after the test, the group treated with 400 mg PAS showed decreased distress. These data provide initial evidence for a selective stress dampening effect of PAS on the pituitary-adrenal axis, suggesting the potential of PAS in the treatment of stress related disorders.

  17. Colombian coal production and export ports

    Energy Technology Data Exchange (ETDEWEB)

    Ruiseco, M.C. [Carbones del Caribe SA (Colombia)

    1996-12-31

    The present situation in Colombia regarding producing and shipping coal is summarised. Coal mined in North Cerrejon is shipped form the port of Puerto Bolivar. This port and its infrastructure could be expanded to cope with increased production from North Cerrejon and may be also from Central Cerrejon. Alternatively, a port could be built at Rio Canas in La Guajira. In the Cienaga-Santa Marta area, Drummond`s port, the port of Santa Marta operated by Carboandes, and Prodeco`s port between Santa Marta and Cienaga export coal from the Cesarregion Propuerto. Consultants are assessing the building of another port in an area called Mallorquin at the mouth of the Magdalena River. By the dawn of the 21st century, Colombia should be able to produce over 50 million tons of coal annually, with low ash and sulphur contents suitable to satisfy the world`s environmental regulations.

  18. 48 CFR 47.303-12 - Ex dock, pier, or warehouse, port of importation.

    Science.gov (United States)

    2010-10-01

    ... warehouse, port of importation. 47.303-12 Section 47.303-12 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 47.303-12 Ex dock, pier, or warehouse, port of importation. (a) Explanation of delivery term. Ex dock, pier, or warehouse...

  19. Port Video and Logo

    OpenAIRE

    Whitehead, Stuart; Rush, Joshua

    2013-01-01

    Logo PDF files should be accessible by any PDF reader such as Adobe Reader. SVG files of the logo are vector graphics accessible by programs such as Inkscape or Adobe Illustrator. PNG files are image files of the logo that should be able to be opened by any operating system's default image viewer. The final report is submitted in both .doc (Microsoft Word) and .pdf formats. The video is submitted in .avi format and can be viewed with Windows Media Player or VLC. Audio .wav files are also ...

  20. Nuclear analysis of ITER Test Blanket Module Port Plug

    Energy Technology Data Exchange (ETDEWEB)

    Villari, Rosaria, E-mail: rosaria.villari@enea.it [ENEA, Fusion Technical Unit, Nuclear Technologies Laboratory, Via Enrico Fermi 45, 00044 Frascati, Rome (Italy); Kim, Byoung Yoon; Barabash, Vladimir; Giancarli, Luciano; Levesy, Bruno; Loughlin, Michael; Merola, Mario [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 Saint Paul-lez-Durance Cedex (France); Moro, Fabio [ENEA, Fusion Technical Unit, Nuclear Technologies Laboratory, Via Enrico Fermi 45, 00044 Frascati, Rome (Italy); Pascal, Romain [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 Saint Paul-lez-Durance Cedex (France); Petrizzi, Luigino [European Commission, DG Research & Innovation G5, CDMA 00/030, B-1049 Brussels (Belgium); Polunovsky, Eduard; Van Der Laan, Jaap G. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 Saint Paul-lez-Durance Cedex (France)

    2015-10-15

    Highlights: • 3D nuclear analysis of the ITER TBM Port Plug (PP). • Calculations of neutron fluxes, nuclear heating, damage and He-production in TBM PP components. • Shutdown dose rate assessment with Advanced D1S method considering different configurations. • Potential design improvements to reduce the shutdown dose rate in the port interspace. - Abstract: Nuclear analyses have been performed for the ITER Test Blanket Module Port Plug (TBM PP) using the MCNP-5 Monte Carlo Code. A detailed 3D model of the TBM Port Plug with dummy TBM has been integrated into the ITER MCNP model (B-lite v.3). Neutron fluxes, nuclear heating, helium production and neutron damage have been calculated in all the TBM PP components. Global shutdown dose rate calculations have also been performed with Advanced D1S method for different configurations of the TBM PP system. This paper presents the results of these analyses and discusses potential design improvements aiming to further reduce the shutdown dose rate in the port interspace.

  1. Faux pas detection and intentional action in Asperger Syndrome. A replication on a French sample.

    Science.gov (United States)

    Zalla, Tiziana; Sav, Anca-Maria; Stopin, Astrid; Ahade, Sabrina; Leboyer, Marion

    2009-02-01

    In the present study, we investigated mind reading abilities in a group of adults with Asperger Syndrome (AS) by using the faux pas task, an advanced test of theory of mind (Baron-Cohen et al. (1999). Journal of Autism and Developmental Disorders, 29, 407-418). The faux pas is a particular case of a non-intentional action reflecting an involuntary socially inappropriate behavior. Here, individuals with AS over-detected faux pas stories, failed to provide correct justifications of the speaker's behavior and were unaware of the mistaken belief and of the resulting emotional impact, whereas they appeared to be responsive to social rule violations. We hypothesized that because of an impaired theory-of-mind, individuals with AS may develop compensatory cognitive strategies based on overlearned abstract knowledge about normative rules.

  2. Epitaxial nanowire formation in metamorphic GaAs/GaPAs short-period superlattices

    Science.gov (United States)

    Zheng, Nan; Ahrenkiel, S. Phillip

    2017-07-01

    Metamorphic growth presents routes to novel nanomaterials with unique properties that may be suitable for a range of applications. We discuss self-assembled, epitaxial nanowires formed during metalorganic chemical vapor deposition of metamorphic GaAs/GaPAs short-period superlattices. The heterostructures incorporate strain-engineered GaPAs compositional grades on 6°-B miscut GaAs substrates. Lateral diffusion within the SPS into vertically aligned, three-dimensional columns results in nanowires extending along A directions with a lateral period of 70-90 nm. The microstructure is probed by transmission electron microscopy to confirm the presence of coherent GaAs nanowires within GaPAs barriers. The compositional profile is inferred from analysis of {200} dark-field image contrast and lattice images.

  3. Criterion validity of the Physical Activity Scale (PAS2) in Danish adults

    DEFF Research Database (Denmark)

    Lunde Pedersen, Eva Sophie; Mortensen, L H; Brage, S

    2017-01-01

    and heart rate sensor for seven days. Average daily estimates from PAS2 were categorised into time spent in sedentary behaviour, light PA, moderate PA and vigorous PA and were compared to the objective measures. RESULTS: PAS2 accounted for 19.5 hours/day on average. Time spent in sedentary behaviour, light...... and moderate-intensity PA was weakly correlated with objective data (polychoric correlation coefficients (PCC): 0.18-0.20), whereas vigorous intensity PA was moderately correlated (PCC: 0.54, p = 0.04). Mean bias was -2.3 hours/day (95% limits of agreement (LoA): -9.04 to 4.34) for sedentary behaviour, 1....... CONCLUSIONS: PAS2 overestimated time spent on light, moderate and vigorous intensity PA and underestimated time spent on sedentary behaviour. Validity differed by key socio-demographic characteristics....

  4. Comparison of results of recording made with the use of the PAS-2 and WLIS equipment

    Energy Technology Data Exchange (ETDEWEB)

    Kornowski, J.; Mirek, A.; Wasko, A. (Glowny Instytut Gornictwa, Katowice (Poland))

    1990-07-01

    Deals with the applicability of rock burst hazard criteria used with the PAS-2 seismoacoustic equipment to results of seismoacoustic recordings obtained with the aid of the WLIS multichannel seismoacoustic pulse counter. Differences between the two equipment types are discussed. Number of pulses recorded was counted both in laboratory and during in situ tests in the Sosnica mine. The WLIS apparatus does not cause the rock burst hazard to be rated lower than the rating obtained with the PAS-2 equipment. At low hazard levels the results are practically the same. At high hazard levels the WLIS apparatus records more pulses, however both instruments produce high ratings. The conclusion is reached that the criteria used with the PAS-2 apparatus can be used unchanged with the WLIS equipment. The WLIS apparatus has a detection threshold that adapts automatically to the actual noise and interference level, thus it can be used in more difficult conditions.

  5. A Collaboration Service Model for a Global Port Cluster

    Directory of Open Access Journals (Sweden)

    Keith K.T. Toh

    2010-03-01

    Full Text Available The importance of port clusters to a global city may be viewed from a number of perspectives. The development of port clusters and economies of agglomeration and their contribution to a regional economy is underpinned by information and physical infrastructure that facilitates collaboration between business entities within the cluster. The maturity of technologies providing portals, web and middleware services provides an opportunity to push the boundaries of contemporary service reference models and service catalogues to what the authors propose to be "collaboration services". Servicing port clusters, portal engineers of the future must consider collaboration services to benefit a region. Particularly, service orchestration through a "public user portal" must gain better utilisation of publically owned infrastructure, to share knowledge and collaborate among organisations through information systems.

  6. J-PAS: The Javalambre-Physics of the Accelerated Universe Astrophysical Survey

    OpenAIRE

    Benitez, N.; Dupke, R.; Moles, M.; Sodre, L.; Cenarro, J.; Marin-Franch, A.; Taylor, K.; Cristobal, D.; Fernandez-Soto, A.; de Oliveira, C. Mendes; Cepa-Nogue, J.; Abramo, L. R.; Alcaniz, J. S.; Overzier, R.; Hernandez-Monteagudo, C.

    2014-01-01

    The Javalambre-Physics of the Accelerated Universe Astrophysical Survey (J-PAS) is a narrow band, very wide field Cosmological Survey to be carried out from the Javalambre Observatory in Spain with a purpose-built, dedicated 2.5m telescope and a 4.7 sq.deg. camera with 1.2Gpix. Starting in late 2015, J-PAS will observe 8500sq.deg. of Northern Sky and measure $0.003(1+z)$ photo-z for $9\\times10^7$ LRG and ELG galaxies plus several million QSOs, sampling an effective volume of $\\sim 14$ Gpc$^3$...

  7. Single port radical prostatectomy: current status.

    Science.gov (United States)

    Martín, Oscar Darío; Azhar, Raed A; Clavijo, Rafael; Gidelman, Camilo; Medina, Luis; Troche, Nelson Ramirez; Brunacci, Leonardo; Sotelo, René

    2016-06-01

    The aim of this study is to analyze the current literature on single port radical prostatectomy (LESS-RP). Single port radical prostatectomy laparoendoscopic (LESS-RP) has established itself as a challenge for urological community, starting with the proposal of different approaches: extraperitoneal, transperitoneal and transvesical, initially described for laparoscopy and then laparoscopy robot-assisted. In order to improve the LESS-RP, new instruments, optical devices, trocars and retraction mechanisms have been developed. Advantages and disadvantages of LESS-RP are controversial, while some claim that it is a non-trustable approach, regarding the low cases number and technical difficulties, others acclaim that despite this facts some advantages have been shown and that previous described difficulties are being overcome, proving this is novel proposal of robotics platform, the Da Vinci SP, integrating the system into "Y". The LESS-RP approach gives us a new horizon and opens the door for rapid standardization of this technique. The few studies and short series available can be result of a low interest in the application of LESS-RP in prostate, probably because of the technical complexity that it requires. The new robotic platform, the da Vinci SP, shows that it is clear that the long awaited evolution of robotic technologies for laparoscopy has begun, and we must not lose this momentum.

  8. Tempered Water Lower Port Connector Structural Analysis Verification

    Energy Technology Data Exchange (ETDEWEB)

    CREA, B.A.

    2000-05-05

    Structural analysis of the lower port connection of the Tempered Water System of the Cold Vacuum Drying Facility was performed. Subsequent detailed design changes to enhance operability resulted in the need to re-evaluate the bases of the original analysis to verify its continued validity. This evaluation is contained in Appendix A of this report. The original evaluation is contained in Appendix B.

  9. Port-Hamiltonian modeling for soft-finger manipulation

    NARCIS (Netherlands)

    Ficuciello, F.; Carloni, R.; Visser, L. C.; Stramigioli, S.

    2010-01-01

    In this paper, we present a port-Hamiltonian model of a multi-fingered robotic hand, with soft-pads, while grasping and manipulating an object. The algebraic constraints of the interconnected systems are represented by a geometric object, called Dirac structure. This provides a powerful way to

  10. Architecture of the soluble receptor Aer2 indicates an in-line mechanism for PAS and HAMP domain signaling.

    Science.gov (United States)

    Airola, Michael V; Huh, Doowon; Sukomon, Nattakan; Widom, Joanne; Sircar, Ria; Borbat, Peter P; Freed, Jack H; Watts, Kylie J; Crane, Brian R

    2013-03-11

    Bacterial receptors typically contain modular architectures with distinct functional domains that combine to send signals in response to stimuli. Although the properties of individual components have been investigated in many contexts, there is little information about how diverse sets of modules work together in full-length receptors. Here, we investigate the architecture of Aer2, a soluble gas-sensing receptor that has emerged as a model for PAS (Per-Arnt-Sim) and poly-HAMP (histidine kinase-adenylyl cyclase-methyl-accepting chemotaxis protein-phosphatase) domain signaling. The crystal structure of the heme-binding PAS domain in the ferric, ligand-free form, in comparison to the previously determined cyanide-bound state, identifies conformational changes induced by ligand binding that are likely essential for the signaling mechanism. Heme-pocket alternations share some similarities with the heme-based PAS sensors FixL and EcDOS but propagate to the Iβ strand in a manner predicted to alter PAS-PAS associations and the downstream HAMP junction within full-length Aer2. Small-angle X-ray scattering of PAS and poly-HAMP domain fragments of increasing complexity allow unambiguous domain assignments and reveal a linear quaternary structure. The Aer2 PAS dimeric crystal structure fits well within ab initio small-angle X-ray scattering molecular envelopes, and pulsed dipolar ESR measurements of inter-PAS distances confirm the crystallographic PAS arrangement within Aer2. Spectroscopic and pull-down assays fail to detect direct interactions between the PAS and HAMP domains. Overall, the Aer2 signaling mechanism differs from the Escherichia coli Aer paradigm, where side-on PAS-HAMP contacts are key. We propose an in-line model for Aer2 signaling, where ligand binding induces alterations in PAS domain structure and subunit association that is relayed through the poly-HAMP junction to downstream domains. Copyright © 2012 Elsevier Ltd. All rights reserved.

  11. Port Infrastructure in Colombia: Asymmetries between Buenaventura’s Port and Cartagena’s Port for the Year 2015

    Directory of Open Access Journals (Sweden)

    Ofelia Castro Castell

    2016-10-01

    Full Text Available The economic dynamics of the 80s and 90s decade, with what has passed twenty-first century, have set new interests and trade relations, impacting, among other things, maritime trade routes. This research work aims to provide a diagnosis of infrastructural Buenaventura port status compared with the port of Cartagena, performing a thorough search of informative data, statistics, and reports; to define the asymmetries between the two ports. The results indicate a clear lack of state support and disorganization in the internal processes of management of the port of Buenaventura, which, ultimately, does not have sufficient capacity to receive and dispatch goods, which generates an increase in time and in operating costs in export and import processes. Buenaventura port infrastructure is below the level of the port of Cartagena.

  12. Effects of the bHLH domain on axial coordination of heme in the PAS-A domain of neuronal PAS domain protein 2 (NPAS2): conversion from His119/Cys170 coordination to His119/His171 coordination.

    Science.gov (United States)

    Uchida, Takeshi; Sagami, Ikuko; Shimizu, Toru; Ishimori, Koichiro; Kitagawa, Teizo

    2012-03-01

    Neuronal PAS domain protein 2 (NPAS2), which is a CO-dependent transcription factor, consists of a basic helix-loop-helix domain (bHLH), and two heme-containing PAS domains (PAS-A and PAS-B). In our previous study on the isolated PAS-A domain, we concluded that His119 and Cys170 are the axial ligands of the ferric heme, while Cys170 is replaced by His171 upon reduction of heme (Uchida et al., J. Biol. Chem. 270, (2005) 21358-21368.). Recently, we characterized the PAS-A domain combined with the N-terminal bHLH domain, and found that some spectroscopic features were different from those of the isolated PAS-A domain (Mukaiyama et al., FEBS J. 273, (2006) 2528-2539.). Therefore, we reinvestigated the coordination structure of heme in the bHLH-PAS-A domain and prepared four histidine and one cysteine mutants. Resonance Raman spectrum of the Cys170Ala mutant is the same as that of wild type with a dominant 6-coordinate heme in the ferric form. In contrast, His119Ala and His171Ala mutants significantly increase amounts of the 5-coordinate species, indicating that His119 and His171, not Cys170, are axial ligands of the ferric heme in the bHLH-PAS-A domain. We had confirmed that the coordination structure of the isolated PAS-A domain is in equilibrium between Cys-Fe-His and His-Fe-His coordinated species but newly found that interaction of the PAS-A domain with the bHLH domain shifts the equilibrium toward the latter structure. Such flexibility in the heme coordination structure seems to be in favor of signal transduction in NPAS2. Copyright © 2011 Elsevier Inc. All rights reserved.

  13. Robust and optimal control a two-port framework approach

    CERN Document Server

    Tsai, Mi-Ching

    2014-01-01

    A Two-port Framework for Robust and Optimal Control introduces an alternative approach to robust and optimal controller synthesis procedures for linear, time-invariant systems, based on the two-port system widespread in electrical engineering. The novel use of the two-port system in this context allows straightforward engineering-oriented solution-finding procedures to be developed, requiring no mathematics beyond linear algebra. A chain-scattering description provides a unified framework for constructing the stabilizing controller set and for synthesizing H2 optimal and H∞ sub-optimal controllers. Simple yet illustrative examples explain each step. A Two-port Framework for Robust and Optimal Control  features: ·         a hands-on, tutorial-style presentation giving the reader the opportunity to repeat the designs presented and easily to modify them for their own programs; ·         an abundance of examples illustrating the most important steps in robust and optimal design; and ·   �...

  14. Knowledge construction about port performance evaluation: An international literature analysis

    Directory of Open Access Journals (Sweden)

    Karine Somensi

    2017-10-01

    Full Text Available Purpose: This study aims at identifying and analyzing the characteristics of international scientific research that address the literature fragment referring to the Port Performance Evaluation to identify the existence of theoretical alignment of Performance Evaluation notion, as an area of knowledge, with practical area stage, the Port Performance Evaluation. Design/Methodology/Approach: The approach the problem, this paper makes use of qualitative research, since it analyzes the Bibliographical Portfolio characteristics related to the Performance Evaluation Port. The strategy adopted was action research where the authors through their analysis and interpretation made the selection of the  Bibliographical Portfolio. Findings: From the analyzed literature fragment it was possible to identify some misalignment between what has been pointed out in the literature regarding the management practices in the port sector. This discrepancy refers to the management practices that are ignored by port managers, which implies the loss of opportunities and may even come to jeopardize the organization's performance. Research limitations/implications: The literature search was restricted to articles written in the English language, published in indexed scientific journals in the selected databases (ii the restriction by the time limit of articles published after the year 2000; (iii the generation of knowledge based on the characteristics selected by the researchers and (iv the analysis of BP articles regarding the  by the judgment and interpretation of this research authors. It is suggested for future work the expanding this research to other databases, other languages, other features, and continuity of this investigation with the development of "systemic analysis' and 'identifying research opportunities' stages through ProKnow-C. Originality/value: Although two similar works have been developed in the same area of research in 2015, the results achieved have

  15. Screening of new entrants for tuberculosis: responses to port notifications.

    Science.gov (United States)

    Hogan, Helen; Coker, Richard; Gordon, Alex; Meltzer, Margie; Pickles, Hilary

    2005-06-01

    Tuberculosis in England and Wales is associated with recently arrived immigrants. Screening new entrants for tuberculosis has received considerable attention recently. Despite several calls to reorganize screening processes for new entrants because of perceived ineffectiveness, some systems at ports have remained largely unchanged, including notification arrangements. A postal questionnaire was sent to Consultants in Communicable Disease Control (CsCDC) who normally receive port health notification forms from London Heathrow Port Health Control Unit relating to new entrants who had either been screened and found to have a normal chest X-ray, not had an chest X-ray due to pregnancy or young age or whose examination was inconclusive (Port 101 and 102 forms). Almost half of the responding CsCDC attempted to follow-up all Port 101 and 102 referrals; of these CsCDC, 46 percent reported that they were actually able to follow-up under 50 percent. CsCDC had developed their own criteria to aid decisions as to which referrals to follow-up. The follow-up by CsCDC of new entrants passing through Heathrow Port Health Control Unit who have been screened and found to have a normal chest X-ray, not had an X-ray due to pregnancy or young age, or whose examination was inconclusive varies considerably and there is no consistent national practice. Substantial efforts are being expended on attempting to follow-up new entrants, many of whom may be at low risk of tuberculosis. The effectiveness (and efficiency) of this approach is probably low.

  16. The Challenges of Malaysian Dry Ports Development

    Directory of Open Access Journals (Sweden)

    Jagan Jeevan

    2015-03-01

    Full Text Available This paper examines the functions and challenges of dry ports development in Malaysia through 11 face-to-face interviews with dry port stakeholders. The findings reveal that Malaysian dry ports are developed to accelerate national and international business, to activate intermodalism in the nation, to promote regional economic development and to enhance seaport competitiveness. Malaysian dry ports perform the function of transport and logistics, information processing, seaports and value-added services. Challenges facing Malaysian dry ports include insufficient railway tracks, unorganized container planning on the rail deck, highly dependent on single mode of transportation, poor recognition from the seaport community, and competition from localized seaports. This paper further indicates strategies for coping with these challenges and identifies future opportunities for Malaysian dry ports development.

  17. Crystal structure of the PAS domain of the hEAG potassium channel.

    Science.gov (United States)

    Tang, Xue; Shao, Juan; Qin, Xiaohong

    2016-08-01

    KCNH voltage-gated potassium channels play critical roles in regulating cellular functions. The channel is composed of four subunits, each of which contains six transmembrane helices forming the central pore. The cytoplasmic parts of the subunits present a Per-Arnt-Sim (PAS) domain at the N-terminus and a cyclic nucleotide-binding homology domain at the C-terminus. PAS domains are conserved from prokaryotes to eukaryotes and are involved in sensing signals and cellular responses. To better understand the functional roles of PAS domains in KCNH channels, the structure of this domain from the human ether-à-go-go channel (hEAG channel) was determined. By comparing it with the structures of the Homo sapiens EAG-related gene (hERG) channel and the Drosophila EAG-like K(+) (dELK) channel and analyzing the structural features of the hEAG channel, it was identified that a hydrophobic patch on the β-sheet may mediate interaction between the PAS domain and other regions of the channel to regulate its functions.

  18. Psychometric Properties and Norms of the German ABC-Community and PAS-ADD Checklist

    Science.gov (United States)

    Zeilinger, Elisabeth L.; Weber, Germain; Haveman, Meindert J.

    2011-01-01

    Aim: The aim of the present study was to standardize and generate psychometric evidence of the German language versions of two well-established English language mental health instruments: the "Aberrant Behavior Checklist-Community" (ABC-C) and the "Psychiatric Assessment Schedule for Adults with Developmental Disabilities" (PAS-ADD) Checklist. New…

  19. Whole-genome sequence of Starmerella bacillaris PAS13, a nonconventional enological yeast with antifungal activity

    DEFF Research Database (Denmark)

    Lemos Junior, Wilson Jose Fernandes; Treu, Laura; Duarte, Vinicius da Silva

    2017-01-01

    Starmerella bacillaris is a fermentative yeast commonly found in vineyards. Here, we present the draft genome sequence of S. bacillaris PAS13, a nonconventional enological yeast with a potential role as a biocontrol agent. This gene sequence will provide insights into the genetic basis of yeast a...... activity against gray mold disease (Botrytis cinerea)....

  20. Peer Relations and the Understanding of Faux Pas: Longitudinal Evidence for Bidirectional Associations

    Science.gov (United States)

    Banerjee, Robin; Watling, Dawn; Caputi, Marcella

    2011-01-01

    Research connecting children's understanding of mental states to their peer relations at school remains scarce. Previous work by the authors demonstrated that children's understanding of mental states in the context of a faux pas--a social blunder involving unintentional insult--is associated with concurrent peer rejection. The present report…

  1. Test report for PAS-1 cask certification for shipping payload B

    Energy Technology Data Exchange (ETDEWEB)

    MERCADO, J.E.

    1998-10-13

    This test report documents the successful inspection and testing to certify two NuPac PAS-1 casks in accordance with US Department of Energy Certificate of Compliance (CoC) USA/9184/B(U). The primary and secondary containment vessels of each cask met the acceptance criteria defined in the CoC and the test plan.

  2. Neuchatel ne gardera pas le Palais de l'equilibre apres Expo.02

    CERN Multimedia

    2002-01-01

    "La ville de Neuchatel ne souhaite pas conserver le Palais de l'equilibre apres Expo.02. Par 24 voix contre 7, le Conseil general a rejete le plan special du Conseil communal qui proposait de transformer l'edifice en un centre de congres" (1/2 page).

  3. Minimizing Ports During Robotic Partial Nephrectomy

    OpenAIRE

    Argun, Omer Burak; Mourmouris, Panagiotis; Tufek, Ilter; Obek, Can; Tuna, Mustafa Bilal; Keskin, Selcuk; Kural, Ali Riza

    2016-01-01

    Background and Objective: Robotic upper urinary tract surgery is in most of the cases performed utilizing a standard 5 port configuration. Fewer ports can potentially produce a less invasive operation. Taking in consideration the above we report a novel technique for robot assisted laparoscopic partial nephrectomy utilizing fewer ports and we test its feasibility and safety profile. Methods: Data on 11 robot-assisted laparoscopic partial nephrectomies performed by using our technique from Feb...

  4. Port wine characterisation and positioning in Portugal

    OpenAIRE

    Loureiro, Norberto; Fernandes, Paula O.

    2011-01-01

    Port wine is a fortified wine produced in the demarcated region of Douro. This region is situated in the northeast of Portugal, in the Douro hydrographical basin, surrounded by mountains that give it exclusive mesologic, climacteric and agrologic characteristics that enable the production of quality wines. Port wine is the most successful of all Portuguese wines throughout the years, home and abroad. This article aims at characterizing and analysing the positioning of the Port Wine brand i...

  5. THE Port - hackathon at CERN

    CERN Multimedia

    CERN. Geneva; KNAEPPER, Ines; SILVA DE SOUSA, Bruno

    2014-01-01

    THE Port association combines creative minds from CERN and non-profit organisations in interdisciplinary teams to work on humanitarian technology related benefits to society. Our interdisciplinary teams of handpicked individuals chosen for their field-leading expertise and innovative mind combine humanitarian questions with state of the art science, cutting-edge technology and endless fantasy. We aim to impact the future by fusion of today’s real life problems analysis and vision of scientific evolution of the next decades. This forces us to develop concepts and solutions for the future - hungry to use our expertise in challenges of new fields.

  6. POLICY PORT IN LATIN AMERICA

    Directory of Open Access Journals (Sweden)

    María Victoria Flores

    2012-07-01

    Full Text Available This work achieves a contextual approach the port services market in Latin America, from the document review the legal framework and jurisprudence. It observes and evaluates the phenomenon under study, establishing a correlation between the grant in the shape of the free supply and demand for services and operating in a market of few suppliers, resulting in national legislation and concession contracts defending a free market and on the other hand, case law on market practice indicating that there is no free market to defend.

  7. US Army Corps of Engineers Ports, Geographic WGS84, BTS (2006) [usace_port_BTS_2006

    Data.gov (United States)

    Louisiana Geographic Information Center — Contains physical information on commercial facilities at the principal U.S. Coastal, Great Lakes and Inland Ports. The data consists of listings of port area's...

  8. Port retrieval for salvage of tissue expansion in case of lost or malfunctioning port

    Directory of Open Access Journals (Sweden)

    Makhija Lalit

    2010-01-01

    Full Text Available Tissue expansion though a promising modality of reconstructive surgery is fraught with many complications. In addition to expander-related complications, subcutaneous port-related mishaps during tissue expansion, though infrequent, can result in procedure failures. We are reporting two patients with port-related complications. In one patient, there was failure to localise the port and the other had a leaking port. Both the expanders were salvaged by retrieving the ports. In the former, as the port was competent, it was simply exteriorised. But in the later case, the connecting tube was retrieved and the incompetent port was replaced with a Luer lock external port. Both the cases were successfully salvaged without any further complications. Expansions were completed and requisite reconstructive end points were achieved.

  9. Towards Sustainable ASEAN Port Development: Challenges and Opportunities for Vietnamese Ports

    National Research Council Canada - National Science Library

    Saeyeon Roh; Vinh V. Thai; Yiik Diew Wong

    2016-01-01

    Sustainability agendas are challenging port authorities around the world to find ways of operating and managing their ports efficiently and effectively in terms of economic, social, as well as environmental development...

  10. Pas de Vallgornera Cave, Majorca (Spain): one the largest littoral caves in Europe; La cueva des Pas de Vallgornera, Mallorca (Espana): unas de las cuevas litorales mas grandes de Europa

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, B.; Mulet, T.; Rodriguez-Homar, M.; Merino, A.

    2016-07-01

    The Pas de Vallgornera cave is the longest cave in the Balearic Islands and one of the largest in Europe (more than 73 km long). It is found on the Miocene reef of Llucmajor Platform and its genesis is related to the development of normal faults and associated fracture systems with N 180° S and N 60° E orientation that took place during the Neogene. It is noteworthy for the abundance, variety and beauty of the speleothems, paleontological richness and to present evidence of hypogene basal recharge. Due to its singularity, it has served as the basis of several scientific studies on groundwater level fluctuations during the quaternary period and others related to the existence of one of most important paleontological sites in Mallorca as far as vertebrates are concerned. (Author)

  11. PortVis: A Tool for Port-Based Detection of Security Events

    Energy Technology Data Exchange (ETDEWEB)

    McPherson, J; Ma, K; Krystosk, P; Bartoletti, T; Christensen, M

    2004-06-29

    Most visualizations of security-related network data require large amounts of finely detailed, high-dimensional data. However, in some cases, the data available can only be coarsely detailed because of security concerns or other limitations. How can interesting security events still be discovered in data that lacks important details, such as IP addresses, network security alarms, and labels? In this paper, we discuss a system we have designed that takes very coarsely detailed data-basic, summarized information of the activity on each TCP port during each given hour-and uses visualization to help uncover interesting security events.

  12. Perancangan Miniatur Traffic Light Dengan Mempergunakan Pengendali Port Paralel

    Directory of Open Access Journals (Sweden)

    Eka Wahyudi

    2012-05-01

    Full Text Available Port paralel tentunya sudah tidak asing lagi dalam dunia komputer. Hal tersebut disebabkan karena port paralel merupakan sarana komunikasi yang terdapat pada Personal Computer (PC. Dengan memanfaatkan port tersebut, saat ini komputer juga dapat dipergunakan untuk keperluan pengontrolan/pengendalian rangkaian listrik dengan memanfaatkan port paralel (port printer. Port paralel memiliki kecepatan transfer data yang lebih cepat apabila dibandingkan dengan port serial, maka dari itu port paralel lebih banyak dipergunakan untuk pengendalian nyala lampu (LED. Dengan memanfaatkan bantuan software Saraf Listrik versi 1.01, maka port paralel dapat menjadi alternatif baru untuk pengendalian traffic light.

  13. Implication of world coal demand on U. S. port strategic planning. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Osleeb, J.P.; Ratick, S.J.; Buckley, P.; Lee, K.; Kuby, M.

    1983-10-01

    The Coal Logistics System (COLS) is developed and used to determine the effects of world coal demands on U.S. ports. The model simultaneously solves for the optimal sources and qualities of coal for export, systemwide least cost routes and modes for transporting coal, and the locations and activity levels of coal transhipments, or other maritime improvements at U.S. ports. Information regarding the necessary investment in coal handling equipment and operating costs at those ports is also provided. A number of scenarios were run with COLS, differing by assumptions made and data used. Some ports were found to have locational advantages with respect to the source of coal vis-a-vis its demand. Scenario results indicate that other ports can participate in the export trade without an appreciable increase in systemwide costs and could be encouraged to do so to increase reliability of U.S. coal supply and foster competition.

  14. Rationalization of servicing reefer containers in sea port area with taking into account risk influence

    Directory of Open Access Journals (Sweden)

    Filina-Dawidowicz Ludmiła

    2014-04-01

    Full Text Available This paper is aimed at presentation of a set of methods for rationalization of servicing containerized refrigerated cargoes in sea ports. During servicing reefer containers in port container terminals, take place various combinations of risk factors which can lead to loss of quality merits of cargoes contained in them. In the paper the risk factors capable of influencing quality of cargoes during their servicing in sea port, are identified, and the elaborated model for assessing risk level with the use of assumptions of fuzzy logic theory, is presented. Also, a simulation of servicing reefer containers in port, was performed. Moreover a prototype of an expert system which makes it possible to take correct decisions on servicing reefer containers in sea port, depending on impact level of risk factors, was proposed

  15. Assessment of port sustainability through synthetic indexes. Application to the Spanish case.

    Science.gov (United States)

    Laxe, Fernando González; Bermúdez, Federico Martín; Palmero, Federico Martín; Novo-Corti, Isabel

    2017-06-15

    In general, Synthetic Indexes of sustainability have been applied to specific countries and regions. With some variations, the ones considered simple, such as the case of the Ecological Footprint (EF), have been applied to port areas. The same has not happened with those of a multidimensional nature (Global Synthetics) that still have a minimal and partial presence in the analysis of port sustainability. Understanding that this type of index represents an interesting and novel avenue of research applied to port systems, this contribution analyses and ranks a sample of 16 Spanish Port Authorities that group 23 ports of general interest using a Global Synthetic Index of Sustainability (developed using the four dimensions of sustainable development: economic, institutional, environmental and social). Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Non-Price Competition in the Port Sector: A Case Study of Ports in Turkey

    OpenAIRE

    Esmer, Soner; Nguyen, Hong-Oanh; Bandara, Yapa Mahinda; Yeni, Kazim

    2016-01-01

    Although the port sector has been facing increasing competition, there is limited research on how ports compete using non-price competition strategies. There are a few studies on non-price competition in the port sector. However they mainly focus on the marketing aspect. This paper seeks to fill this gap in the literature, especially from a combined marketing-economic perspective. Especially the paper's main objective is to identify the determinants of non-price competition in the port sector...

  17. Managing Port Reforms in India: Case Study of Jawaharlal Nehru Port Trust (JNPT) Mumbai

    OpenAIRE

    Ray, Amit S.

    2004-01-01

    JNPT was established with the goal of creating a world-class port and, though it enjoyed an edge over other Indian ports with respect to both infrastructure and performance, inherent drawbacks prevented it from achieving world standards in port efficiency. JNPT was selected as a test case in the privatization of port operations and key reforms undertaken have been reasonably successful. With the creation of a new private terminal and the follow-up measures undertaken thereafter, JNPT has demo...

  18. CAD-Based Shielding Analysis for ITER Port Diagnostics

    Science.gov (United States)

    Serikov, Arkady; Fischer, Ulrich; Anthoine, David; Bertalot, Luciano; De Bock, Maartin; O'Connor, Richard; Juarez, Rafael; Krasilnikov, Vitaly

    2017-09-01

    Radiation shielding analysis conducted in support of design development of the contemporary diagnostic systems integrated inside the ITER ports is relied on the use of CAD models. This paper presents the CAD-based MCNP Monte Carlo radiation transport and activation analyses for the Diagnostic Upper and Equatorial Port Plugs (UPP #3 and EPP #8, #17). The creation process of the complicated 3D MCNP models of the diagnostics systems was substantially accelerated by application of the CAD-to-MCNP converter programs MCAM and McCad. High performance computing resources of the Helios supercomputer allowed to speed-up the MCNP parallel transport calculations with the MPI/OpenMP interface. The found shielding solutions could be universal, reducing ports R&D costs. The shield block behind the Tritium and Deposit Monitor (TDM) optical box was added to study its influence on Shut-Down Dose Rate (SDDR) in Port Interspace (PI) of EPP#17. Influence of neutron streaming along the Lost Alpha Monitor (LAM) on the neutron energy spectra calculated in the Tangential Neutron Spectrometer (TNS) of EPP#8. For the UPP#3 with Charge eXchange Recombination Spectroscopy (CXRS-core), an excessive neutron streaming along the CXRS shutter, which should be prevented in further design iteration.

  19. Ballast Water Risk Assessment, Ports of Mumbai and Jawaharlal Nehru, India, October 2003: Final Report

    Digital Repository Service at National Institute of Oceanography (India)

    Anil, A.C.; Clarke, C.; Hayes, T.; Hilliard, R.; Joshi, G.; Krishnamurthy, V.; Polglaze, J.; Sawant, S.S.; Raaymakers, S.

    Commercial Sea Port of Odessa (port authority) DGS Directorate General of Shipping (Ministry of Shipping), India DSS Decision support system (for BW management) DWT Deadweight tonnage (typically reported in metric tonnes) GIS Geographic information system... bio-invaders, as it does not depend on the reliability of a decision support system that may not be complete. However, the key disadvantage of the strict blanket approach are the BW management costs imposed on vessels which otherwise might...

  20. Shutdown dose rate contribution from diagnostics in ITER upper port 18

    Energy Technology Data Exchange (ETDEWEB)

    Cheon, M.S., E-mail: munseong@nfri.re.kr [National Fusion Research Institute, Daejeon (Korea, Republic of); Pak, S.; An, Y.H.; Seon, C.R.; Lee, H.G. [National Fusion Research Institute, Daejeon (Korea, Republic of); Bertalot, L.; Krasilnikov, V. [ITER Organization, St Paul-lez-Durance (France); Zvonkov, A. [Agency ITER-RF, Moscow (Russian Federation)

    2016-11-01

    Highlights: • The Shutdown Dose Rate in the interspace of ITER upper port 18 was evaluated. • VUV spectrometer is the dominant contributor to the average SDR. • The existence and size of the blanket cooling pipes impacts significantly on SDR. - Abstract: D-T operation of ITER plasma will produce high-energy fusion neutrons those can activate materials around the place where human-access is necessary. The interspace of the diagnostic port is one of the area where human-access is necessary for the maintenance of diagnostic systems installed at the port, so it is important to evaluate a dose rate of the interspace area in order to comply with ALARA principle. The shutdown dose rate (SDR) in the interspace of ITER upper port 18 was evaluated by the Direct 1-Step (D1S) method using MCNP5 code. This port contains three diagnostics: Vacuum Ultra-Violet (VUV) Spectrometer, Neutron Activation System (NAS), and Upper Vertical Neutron Camera (UVNC). The contribution of each diagnostic in the port was evaluated by running separate upper port MCNP models those contain individual diagnostic only, and the total dose rate contribution was evaluated with the model which was fully integrated with all the diagnostics. The effect of the opening around the upper port plug and of the other ports was also investigated. The purpose of this assessment is to provide the shielding design basis for the preliminary design of the diagnostic integration in the port. The method and result of the calculation will be presented in this paper.

  1. Does Faux Pas Detection in Adult Autism Reflect Differences in Social Cognition or Decision-Making Abilities?

    Science.gov (United States)

    Thiébaut, Flora I.; White, Sarah J.; Walsh, Annabel; Klargaard, Solja K.; Wu, Hsuan-Chen; Rees, Geraint; Burgess, Paul W.

    2016-01-01

    43 typically-developed adults and 35 adults with ASD performed a cartoon faux pas test. Adults with ASD apparently over-detected faux pas despite good comprehension abilities, and were generally slower at responding. Signal detection analysis demonstrated that the ASD participants had significantly greater difficulty detecting whether a cartoon…

  2. Dose regimen of para-aminosalicylic acid gastro-resistant formulation (PAS-GR) in multidrug-resistant tuberculosis.

    Science.gov (United States)

    Kibleur, Yves; Brochart, Hervé; Schaaf, Hendrik S; Diacon, Andre H; Donald, Peter R

    2014-04-01

    Resurgence of multidrug-resistant tuberculosis (MDR-TB) has raised a renewed interest in para-aminosalicylic acid (PAS) and other efficacious drugs. A gastro-resistant granule formulation (PAS-GR) was designed to be better tolerated than earlier forms of PAS, with fewer adverse effects from reduced production of meta-aminophenol. PAS release from PAS-GR granules is slower than with earlier formulations. Pharmacokinetic data are, however, limited and only a few studies have assisted in defining the best PAS-GR dose regimen. Interest in refining the latter continues and recent data contributed in better defining the optimal PAS-GR dose regimen in adults and children. The present paper draws on these recent studies, synthesizes pharmacokinetic results from different population groups, and draws comparisons with in vitro data and the results of earlier pharmacokinetic studies in order to discuss the most appropriate dosing regimen for PAS-GR. A comparative in vitro dissolution study was carried out with a 1 g acid PAS equivalent of various formulations of PAS and PAS-GR and in vitro-in vivo correlations. Retrospective comparisons between recent and earlier clinical studies were also gathered to clarify the dose regimen of PAS-GR in adults and children. Exposure after a 4 g twice- or three times daily dose regimen in adult MDR-TB patients confirmed that both dose regimens can be used. The twice-daily dose regimen does not, however, confer any safety margin over the potentiality of "too" high plasma concentrations after a three times daily dose regimen and may lead to under-dosage when a dose is missed, as compliance often decreases over time. Based on available data and practical considerations, a 4 g three times daily dose regimen of PAS-GR should be the preferred dose in hospital settings, where it remains the best regimen to cover the around-the-clock suppression of mycobacteria based on the minimal inhibitory concentration for PAS. In MDR-TB adults and in hospital

  3. Assessing the quality of energy supplied by small renewable energy systems; Avaliacao da qualidade da energia fornecida por sistemas renovaveis isolados de pequeno porte

    Energy Technology Data Exchange (ETDEWEB)

    Galhardo, Marcos Andre Barros; Pinho, Joao Tavares [Universidade Federal do Para (UFPA), Belem, PA (Brazil). Grupo de Estudos e Desenvolvimento de Alternativas Energeticas], e-mail: galhardo@ufpa.br, E-mail: jtpinho@ufpa.br

    2004-07-01

    This paper makes an analysis of the power quality supplied by small renewable energy systems with energy storage in a battery bank and its DC/AC conversion by an inverter. It is shown that the power quality supplied by stand-alone renewable systems depends on the used inverter, specially of its voltage waveform, the load supplied and the voltage level in the battery bank, which has a direct influence on the value of the rms output voltage of the inverter. For these analysis, measurements are presented for typical loads used in these systems as illumination, TV, refrigerator, etc., and combinations of these loads, supplied by different waveforms. (author)

  4. Climate variability and Port wine quality

    Science.gov (United States)

    Gouveia, Celia; Liberato, Margarida L. R.; Trigo, Ricardo M.; Dacamara, Carlos

    2010-05-01

    Recent warming trends for Portugal have been found to be steepest in winter and spring and more pronounced for minimum than for maximum values of temperature (Miranda et al, 2002). These trends and associated changes in temperature and precipitation regimes may exert strong influences on agriculture systems. For instance, high values of the North Atlantic Oscillation (NAO) index have been shown to significantly reduce precipitation over Iberia and therefore induce low yield wheat crops in Portugal (Gouveia and Trigo, 2006). Port wine is produced from grapes grown in selected areas of the Douro valley, the so-called Região Demarcada do Douro, the first wine-producing region of the world (dating from 1758). A vintage wine is made from grapes that were grown and harvested in a single specified year and is classified as such because of the above average quality, a status that is attributed by Port houses in their best years. The Douro region presents distinctive climatic, topographic and soil characteristics. While the latest factors are fixed in time, the former may considerably change from year to year, exposing the Port wine productions to a large risk associated to interannual and intra-seasonal climatic variations. It is therefore to be expected that high quality wines are generally associated to optimum climatic conditions. In this work we have performed an analysis of the distinct behaviour of several meteorological fields in vintage versus non-vintage years. The relative importance of maximum and minimum temperature, precipitation and frost days is assessed for each individual month of the vegetative cycle and their importance to a high quality wine year is evaluated. Composites of 500 hPa geopotential height and sea level pressure fields over the Euro Atlantic region are also compared for vintage and non-vintage years. Results reveal a strong dependence of vintage production on maximum temperature and precipitation during spring and summer (the growing season

  5. The PAS Domain-Containing Protein HeuR Regulates Heme Uptake in Campylobacter jejuni.

    Science.gov (United States)

    Johnson, Jeremiah G; Gaddy, Jennifer A; DiRita, Victor J

    2016-11-15

    Campylobacter jejuni is a leading cause of bacterially derived gastroenteritis. A previous mutant screen demonstrated that the heme uptake system (Chu) is required for full colonization of the chicken gastrointestinal tract. Subsequent work identified a PAS domain-containing regulator, termed HeuR, as being required for chicken colonization. Here we confirm that both the heme uptake system and HeuR are required for full chicken gastrointestinal tract colonization, with the heuR mutant being particularly affected during competition with wild-type C. jejuni Transcriptomic analysis identified the chu genes-and those encoding other iron uptake systems-as regulatory targets of HeuR. Purified HeuR bound the chuZA promoter region in electrophoretic mobility shift assays. Consistent with a role for HeuR in chu expression, heuR mutants were unable to efficiently use heme as a source of iron under iron-limiting conditions, and mutants exhibited decreased levels of cell-associated iron by mass spectrometry. Finally, we demonstrate that an heuR mutant of C. jejuni is resistant to hydrogen peroxide and that this resistance correlates to elevated levels of catalase activity. These results indicate that HeuR directly and positively regulates iron acquisition from heme and negatively impacts catalase activity by an as yet unidentified mechanism in C. jejuni IMPORTANCE: Annually, Campylobacter jejuni causes millions of gastrointestinal infections in the United States, due primarily to its ability to reside within the gastrointestinal tracts of poultry, where it can be released during processing and contaminate meat. In the developing world, humans are often infected by consuming contaminated water or by direct contact with livestock. Following consumption of contaminated food or water, humans develop disease that is characterized by mild to severe diarrhea. There is a need to understand both colonization of chickens, to make food safer, and colonization of humans, to better

  6. The Sustainability of Mediterranean Port Areas: Environmental Management for Local Regeneration in Valencia

    Directory of Open Access Journals (Sweden)

    Filomena Borriello

    2013-09-01

    Full Text Available Urban renovation projects, which have led to the conversion of port areas through a new vision of waterfronts as elements of the potential development of the urban system in its entirety, have spread since the early 1950s and now some port cities are able to trigger some mechanisms which, even if they are the result of some processes that have been activated for decades and which are still evolving, are able to amplify and to extend over time their generated positive impacts. These impacts also produce a system of relations in the context of the hinterland, attracted also by policies of economic, social, and cultural development. In the case of the city of Valencia, we have seen, in the last 50 years, a progressive spread of the urbanized area to the coasts, simultaneously with a process of renovation of the port area, which has been populated by important architectures, and which has been equipped by efficient infrastructures and subjected to numerous recovery and restoration operations of its historic buildings. However, the environmental conditions near the port area are not well suited to a good quality of life because ports are pollution producers, sites of urban decay, and of social degradation. A good plan can include some instruments to decrease those negative factors, leading to a close merging between the port area and the city hinterland, and generating new economies. The proposal of this research consists in a method of integrating the port planning with an environmental accounting system.

  7. Ranking transmission projects in large scale systems using an AC power flow model; Priorizacao de obras em sistemas de grande porte usando um modelo AC da rede

    Energy Technology Data Exchange (ETDEWEB)

    Melo, A.C.G. [Centro de Pesquisas de Energia Eletrica (CEPEL), Rio de Janeiro, RJ (Brazil); Fontoura Filho, R.N. [ELETROBRAS, Rio de Janeiro, RJ (Brazil); Peres, L.A.P. Pecorelli [FURNAS, Rio de Janeiro, RJ (Brazil); Morozowski Filho, M. [Santa Catarina Univ., Florianopolis, SC (Brazil)

    1994-12-31

    Initially, this paper summarizes the approach developed by the Brazilian Planning Criteria Working Group (GTCP/ELETROBRAS) for identifying which subset of transmission investments should be postponed to meet a pre-stablished budget constraint with the least possible impact on system performance. Next, this paper presents the main features of the computational model PRIO, which allows the application of the ranking process to large scale power systems (2,000 buses and 3,000 circuits), with as many as 100 projects to be ranked. In this model, the adequacy analysis of each system state is carried out through an AC power flow coupled to a successive linear programming based remedial actions model. Case studies with the IEEE-RTS system and a configuration of the Brazilian Southeastern are presented and discussed. (author) 7 refs., 6 figs., 5 tabs.

  8. Return on investment of advanced practice medical degrees: NPs vs. PAs.

    Science.gov (United States)

    Craig, Christopher K; Holmes, James H; Carter, Jeffery E

    2017-06-01

    As the United States faces a predicted physician shortage over the next 2 decades, physician assistants (PAs) and NPs are expected to fill the void. At the same time, because education is expensive, student loan and tuition increases have many potential applicants assessing differences in reimbursement and wondering about their return on investment (ROI). An analysis compared PA and NP salaries by incorporating national salary data, federal income tax, and student loans for a comparative analysis of each career pathway. Salaries were abstracted from the 2012 Bureau of Labor Statistics database. The net present value (NPV) of PA and NP salaries was calculated with a 5% discount rate. Principal and interest for student loans was calculated at a 6% interest fixed-rate loan over 30 years. NPVs were then compared with projected ROI at retirement age. Relative career values were also given to each career choice, based on a retirement age of 65 years, which translates to about 41 years of employment for both PAs and NPs. PAs' and NPs' educational loans both equalled $129,484 on total repayment. The median annual salary of a PA was $90,930 and $89,960 for an NP. PA data yielded a 5% NPV of $781,323 compared with $764,348 for NPs. Of note, the 5% NPV of a 4-year nursing degree is $728,436. PAs have a slightly higher ROI compared with NPs. These findings may change due to adjustments in nursing training models. Many PA programs allow matriculation immediately after obtaining a bachelor's degree. NP schools often require nursing experience before entering their program. Some schools are considering an accelerated NP program, allowing immediate matriculation after obtaining a bachelor's degree. Because many NP programs have become doctoral degrees, the increased duration of training, higher tuition, and fewer years worked before retirement lower the overall NP ROI. A similar reduction in ROI was considered marginal in PAs who attend residency programs-though these programs are

  9. Rotterdam as a World Port City

    NARCIS (Netherlands)

    Menno Huijs; Wouter Jacobs; Isabelle Vries

    2015-01-01

    Most studies and models on the port-city interface focus on the inevitable process in which ports and cities grow apart, both spatially and economically. What is often overlooked is the relationships that remain in the form of maritime business services (finance, insurance, legal). These maritime

  10. Future Scenarios : Implications for Port Planning

    NARCIS (Netherlands)

    Taneja, P.; Walker, W.E.; Ligteringen, H.; Van Schuylenburg, M.; Van der Plas, R.

    2009-01-01

    The evolving function of a port, and the many logistical, technological and economic uncertainties under which it must operate, make the planning and design of these complex socio-technical infrastructures very challenging. A Master Plan of a port is the instrument by which the port’s (expansion)

  11. Flexibility in Port Planning and Design

    NARCIS (Netherlands)

    Taneja, P.; Ligteringen, H.; Walker, W.E.

    2012-01-01

    Recently, flexibility has received much attention from port researchers, designers, and managers. This is because the stability of the competitive environment of the past has been replaced by increasing uncertainty. The current economic crisis and the recent trends in ports and shipping sectors are

  12. Are we connected? : Ports in Global Networks

    NARCIS (Netherlands)

    R.A. Zuidwijk (Rob)

    2015-01-01

    markdownabstractAbstract Global supply chains are built on organizational, information, and logistics networks. Ports are connected via these networks and also need to connect these networks. Synchromodality is an innovative concept for container transportation, and the port plays an important

  13. Cyber security in ports : Business as usual

    NARCIS (Netherlands)

    Moerel, Lokke; Dezeure, Freddy

    2017-01-01

    Our paper summarizes the risks and provides concrete and pragmatic proposals to increase substantially the cyber maturity and resilience in the ports by organizing training and awareness raising, fostering cooperation and information exchange both between the stakeholders in the ports and across the

  14. Lessons from Hurricane Sandy for port resilience.

    Science.gov (United States)

    2013-12-01

    New York Harbor was directly in the path of the most damaging part of Hurricane Sandy causing significant impact on many of the : facilities of the Port of New York and New Jersey. The U.S. Coast Guard closed the entire Port to all traffic before the...

  15. Port-a-caths in cancer patients

    African Journals Online (AJOL)

    1990-01-01

    Jan 1, 1990 ... Abstract We report on 91 patients with cancer who under- went the insertion of89 venous and 4 hepatic arte- rial, implanted vascular ports (port-a-caths) for periods of up to 33 Illonths (total 1 525 patient-. ITlOnths). There were 1 fatal, 9 serious and 8 Illinor. cOlnplications in 18 patients which are described.

  16. Ship waste quantities prediction model for the port of Belgrade

    Directory of Open Access Journals (Sweden)

    VLADANKA PRESBURGER ULNIKOVIĆ

    2011-06-01

    Full Text Available This study focuses on the issues related to the waste management in river ports in general and especially in the port of Belgrade. Data on solid waste, waste oils, oily waters, gray water and black water have been collected for a period of five years. The methodology of data collection is presented. Trends of data were analyzed and the regression model was used to predict the waste quantities in the Belgrade port. This data could be utilized as a basis for the calculation of the equipment capacity for waste selective collection, treatment and storage. The results presented in this study establish the need for an orga¬nized management system for this type of waste which can be achieved either by constructing and providing new specialized terminal or by providing mobile floating facilities and other plants in the Port of Belgrade for these kinds of ser¬vices. In addition to the above, the legislative and organizational strategy of waste management has been explored to complete the study because the im¬pact of good waste management on environment and prevention of environ¬mental accidents would be highly beneficial. This study demonstrated that ad¬dressing these issues should be considered at international as well as national level.

  17. Safety of Navigation on the Approaches to the Ports of the Republic of Poland on the Basis of the Radar System on the Aerostat Platform

    Directory of Open Access Journals (Sweden)

    Krzysztof Szafran

    2015-03-01

    Full Text Available The report depicts technical and organizational possibilities with an aim to increase situational awareness and sea travel safety on the entry to Polish seaports on the base of the dedicated radar system on the aerostat platform. The radar system based on the aerostat can work at the altitude of 3,000 meters, which allows detecting sea vessels and low level flying aircrafts in the range of 150 nm and more. The aerostat based in Siemirowice gives opportunities to monitor movements of sea vessels all over the South Baltic Sea, starting with the Lithuanian seaside with Klaipeda seaport in the east where the sea enters Zatoka Gda?ska and Trójmiasto seaports, movements along the whole Polish seaside up to Sund Straid near Copenhagen and sea routes all along south Swedish coast. On those bases, it is possible to observe movements of sea transports of special interest including Maersk’s big container vessels and gas delivering vessels to Lithuania and to ?winouj?cie. The proposed radar system is using solutions of towed aerostats tested in working conditions which are exploited by the United States of America to monitor its border with Mexico and to observe movements of sea vessels and low flying aircrafts around Florida Peninsula and Puerto Rico islands on the Caribbean. The radar systems used by the USA are depicted with organizational rules of their exploitation. Advantages and these advantages of such a radar system were depicted and some information about dangers related to aerostat’s exploitation is also provided. Additional possibilities of using the radar system based on the aerostat are depicted in the role of a new and important part of the country’s defense system.

  18. Ports Primer: 3.3 Federal and International Governance

    Science.gov (United States)

    State and local governments are important players in port governance and in oversight of transportation projects that may affect ports. Private corporations may also play a role if they lease or own a terminal at a port.

  19. Colonial Origins of the Port of Buenaventura

    Directory of Open Access Journals (Sweden)

    Alonso Valencia Llano

    2014-07-01

    Full Text Available This article studies the origins of the Port of Buenaventura in the New Kingdom of Granada. It begins with the process of exploration of the coastal territory in order to highlight the different sites in which it was situated, demonstrating that it began as a river port and was later resituated and gradually converted into a maritime port. In addition, this article analyzes the problems it faced, such as the dificulty of communication with the interior of the country, the indigenous resistance that caused the destruction of the town, and inally the necessity of populating the zone with black slaves in order to exploit the mining border. This study also discusses how this port was controlled by the elite of the city of Cali, until the Republican period when it became the sole Colombian port on the Paciic Ocean.

  20. Report of the Evaluation Meeting on the Caribbean Information System (Port-of-Spain, Trinidad and Tobago, July 6-8, 1983).

    Science.gov (United States)

    United Nations Economic Commission for Latin America, Port-of-Spain (Trinadad). Caribbean Documentation Centre.

    This publication outlines the activities and impact of the Caribbean Information System for Economic and Social Planning (CARISPLAN), as reported by representatives of 16 Caribbean nations and various regional organizations. A copy of the meeting agenda and other introductory material are followed by brief summaries of reports from representatives…

  1. An In-Port Feeding System for Shipboard Personnel. Volume 2. A Cost Benefit Analysis of the Use of Convenience Foods in a Military Foodservice Operation.

    Science.gov (United States)

    1981-10-01

    and two desserts . In designing the menu, consideration was given to the basic menu planning principles of color, shape, flavor, acceptability...cost using available raw ingredient price lists. The convenience foodservice system combined both convenience and selected conventional food costs...prepared by using ingredients in convenience form. For example, cole slaw could be prepared from precut cabbage, onions end other fresh vegetables

  2. Balanced ScoreCard Y las Normas de Integración PAS 99:2006

    Directory of Open Access Journals (Sweden)

    Soler González, Rafael H.

    2013-12-01

    Full Text Available For the development of this work the authors used the Norton & Kaplan recommendations for the implementation of the Balanced Scorecard (BSC, and novel diagnostic tools as SISTRAT, strategy maps software for LINUX UBUNTU DC Map.xls and development of Box Mando. Once the BSC was implemented, a longitudinal study of data in the scorecard was carried out in order to analyze to what extent the implementation of the BSC in the Design and Engineering Company (EDIN coincided with the seven principles of integration standards PAS 99:2006. For this comparison Hamming´s relative distances were used as a measurement tool. Respective analyzes were performed to the extent that the relative distances were declining which showed that the BSC implemented in EDIN was consistent with PAS 99:2006.

  3. [Safety and validity of port-less forceps in reduced-port surgery for laparoscopic resection of colorectal cancer].

    Science.gov (United States)

    Okamura, Shu; Murata, Kohei; Wada, Yuma; Kato, Ryo; Makino, Shunichiro; Takeoka, Tomohira; Okada, Kazuyuki; Yanagisawa, Tetsu; Fukuchi, Nariaki; Ebisui, Chikara; Yokouchi, Hideoki; Kinuta, Masakatsu

    2013-11-01

    The purpose of this study was to examine the safety and validity of reduced-port surgery( RPS) in comparison with conventional laparoscopic surgery for colorectal cancer. We investigated 64 cases of colorectal cancer( CRC) resected by laparoscopic surgery at our hospital in 2012, including 22 cases resected by RPS using 1 or more port-less forceps( Endo Relief, Hope Electronics, Japan). With regard to safety, Endo Relief yielded satisfactory outcomes in terms of the limitations of other needlescopic devices, such as lack of strength and risk of tissue injury, while maintaining countertraction. In addition to the original reasons for introducing RPS, such as lessening wound pain and improving the cosmetic outcome after surgery, the advantages of RPS for CRC are high cost efficiency and the possibility of using additional forceps to maintain triangulation or countertraction during laparoscopic surgery. Because it involves a port-less system, RPS facilitates the frequent reuse of forceps, thereby contributing to its high cost efficiency. In the introduction of RPS for laparoscopic colorectal resection, the use of port-less forceps for countertraction could be safe and effective.

  4. 1 1) Pourquoi est-ce que je ne parviens pas à ouvrir les formulaires ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    compte des questions comme celles de l'utilisation et des pratiques sont les bienvenues. e) La troisième incidence visée par les Partenariats canadiens ayant trait à l'apprentissage, le programme invite les candidats à sortir de leur zone de confort lorsqu'ils réfléchiront à cet aspect. Il n'est pas question ici des constatations ...

  5. , TOUCHE PAS À MA TERRE, I ! ' C'EST MA VIE !

    International Development Research Centre (IDRC) Digital Library (Canada)

    ce phénomène sur les sociétés locales, à savoir, les risques de multiplication des conflits dans les zones touchées, la perte des moyens de subsistance des populations riveraines et la perturbation de la vie socio-économique et culturelle. C'est suite à ces constats qu'est né le slogan : «Touche pas à ma terre, c'est ma vie !

  6. Pied de Charcot: un diagnostic à ne pas méconnaitre | Khammassi ...

    African Journals Online (AJOL)

    A l'examen clinique on notait un pied droit déformé, indolore, tuméfié dans sa globalité avec une augmentation importante du son volume et un lymphoedème de la jambe. Par ailleurs il n'y avait pas de signes inflammatoires ni fluctuation. La biologie montrait une glycémie élevée (entre 3 et 4 g/l) sans syndrome ...

  7. Practical Analysis of materials with depth varying compositions using FT-IR photoacoustic spectroscopy (PAS)

    Energy Technology Data Exchange (ETDEWEB)

    J.F. McClelland; R.W. Jones; Siquan Luo

    2004-09-30

    FT-IR photoacoustic spectroscopy (PAS) is discussed as a nondestructive method to probe the molecular composition of materials versus depth on the basis of the analysis of layers of experimentally controllable thickness, which are measured from the sample surface to depths of some tens of micrometers, depending on optical and thermal properties. Computational methods are described to process photoacoustic amplitude and phase spectra for both semi-quantitative and quantitative depth analyses. These methods are demonstrated on layered and gradient samples.

  8. A study on N2O measurement characteristics using photoacoustic spectroscopy (PAS).

    Science.gov (United States)

    Kang, Soyoung; Kim, Seoungjin; Kang, Seongmin; Lee, Jeongwoo; Cho, Chang-Sang; Sa, Jea-Hwan; Jeon, Eui-Chan

    2014-08-07

    N2O, which is emitted mainly from nitrogen decomposition via bacteria, livestock manure, agricultural fertilizer use, fossil fuel combustion and waste incineration, is classified as a substance that causes significant destruction of the ozone layer. The N2O measurement methods for these emission sources may be divided into chromatography, optical, and electrical current measurements. Chromatography has been widely utilized for analyzing N2O. However, up until now, few studies have been conducted on N2O using photoacoustic spectroscopy. Therefore, this study aimed to evaluate performance of photoacoustic spectroscopy in this regard based on laboratory and field test results. The repeatability of photoacoustic spectroscopy was measured at 1.12%, which is lower than the repeatability of 3.0% suggested by the ISO 1564 standard, so, it has shown an excellent repeatability. The detection limit was determined to be 0.025 ppm, and the response time was confirmed to be 3 min and 26 s. The results of comparison between these measurements and GC show that the latter has superior accuracy, but mobility and convenience are superior for PAS. On the contrary, GC has a continuous measurement limitation, but PAS makes it possible to conduct continuous measurements. Therefore, PAS can be extremely useful to confirm the characteristics of N2O emissions and to quantify their amount.

  9. A Study on N2O Measurement Characteristics Using Photoacoustic Spectroscopy (PAS

    Directory of Open Access Journals (Sweden)

    Soyoung Kang

    2014-08-01

    Full Text Available N2O, which is emitted mainly from nitrogen decomposition via bacteria, livestock manure, agricultural fertilizer use, fossil fuel combustion and waste incineration, is classified as a substance that causes significant destruction of the ozone layer. The N2O measurement methods for these emission sources may be divided into chromatography, optical, and electrical current measurements. Chromatography has been widely utilized for analyzing N2O. However, up until now, few studies have been conducted on N2O using photoacoustic spectroscopy. Therefore, this study aimed to evaluate performance of photoacoustic spectroscopy in this regard based on laboratory and field test results. The repeatability of photoacoustic spectroscopy was measured at 1.12%, which is lower than the repeatability of 3.0% suggested by the ISO 1564 standard, so, it has shown an excellent repeatability. The detection limit was determined to be 0.025 ppm, and the response time was confirmed to be 3 min and 26 s. The results of comparison between these measurements and GC show that the latter has superior accuracy, but mobility and convenience are superior for PAS. On the contrary, GC has a continuous measurement limitation, but PAS makes it possible to conduct continuous measurements. Therefore, PAS can be extremely useful to confirm the characteristics of N2O emissions and to quantify their amount.

  10. A cell cycle kinase with tandem sensory PAS domains integrates cell fate cues

    Science.gov (United States)

    Mann, Thomas H.; Seth Childers, W.; Blair, Jimmy A.; Eckart, Michael R.; Shapiro, Lucy

    2016-01-01

    All cells must integrate sensory information to coordinate developmental events in space and time. The bacterium Caulobacter crescentus uses two-component phospho-signalling to regulate spatially distinct cell cycle events through the master regulator CtrA. Here, we report that CckA, the histidine kinase upstream of CtrA, employs a tandem-PAS domain sensor to integrate two distinct spatiotemporal signals. Using CckA reconstituted on liposomes, we show that one PAS domain modulates kinase activity in a CckA density-dependent manner, mimicking the stimulation of CckA kinase activity that occurs on its transition from diffuse to densely packed at the cell poles. The second PAS domain interacts with the asymmetrically partitioned second messenger cyclic-di-GMP, inhibiting kinase activity while stimulating phosphatase activity, consistent with the selective inactivation of CtrA in the incipient stalked cell compartment. The integration of these spatially and temporally regulated signalling events within a single signalling receptor enables robust orchestration of cell-type-specific gene regulation. PMID:27117914

  11. [Parental alienation syndrome (PAS): unknown in medical settings, endemic in courts].

    Science.gov (United States)

    Pignotti, Maria Serenella

    2013-02-01

    A purposed syndrome of so-called parental alienation (PAS), unsupported by any evidence-based data, unknown in medical settings, unquoted in medical books, absent in DSM and ICD, never demonstrated by controlled studies published in high scientific level journals, is rampant in Courts where it can lead to loose parental custody. During a divorce trial, almost always the mothers and the children, become joint in a sort of folie au deux, in a denigration campaign of ex-husband/father. From a review on this issue it seems evident its theoretical roots lie on a theory that justify gender violence and children sexual abuse. The bias that both of them are layers and that he children have not autonomy block their possibility of any defence in front of a Court. In severe cases, PAS becomes a new and efficient tool of intra-familiar violence. The treatment of severe cases is to stop any contact between mother and children. The resort to PAS in Courts must be strongly rejected.

  12. DEMO port plug design and integration studies

    Science.gov (United States)

    Grossetti, G.; Boccaccini, L. V.; Cismondi, F.; Del Nevo, A.; Fischer, U.; Franke, T.; Granucci, G.; Hernández, F.; Mozzillo, R.; Strauß, D.; Tran, M. Q.; Vaccaro, A.; Villari, R.

    2017-11-01

    The EUROfusion Consortium established in 2014 and composed by European Fusion Laboratories, and in particular the Power Plant Physics and Technology department aims to develop a conceptual design for the Fusion DEMOnstration Power Plant, DEMO. With respect to present experimental machines and ITER, the main goals of DEMO are to produce electricity continuously for a period of about 2 h, with a net electrical power output of a few hundreds of MW, and to allow tritium self-sufficient breeding with an adequately high margin in order to guarantee its planned operational schedule, including all planned maintenance intervals. This will eliminate the need to import tritium fuel from external sources during operations. In order to achieve these goals, extensive engineering efforts as well as physics studies are required to develop a design that can ensure a high level of plant reliability and availability. In particular, interfaces between systems must be addressed at a very early phase of the project, in order to proceed consistently. In this paper we present a preliminary design and integration study, based on physics assessments for the EU DEMO1 Baseline 2015 with an aspect ratio of 3.1 and 18 toroidal field coils, for the DEMO port plugs. These aim to host systems like electron cyclotron heating launchers currently developed within the Work Package Heating and Current Drive that need an external radial access to the plasma and through in-vessel systems like the breeder blanket. A similar approach shown here could be in principle followed by other systems, e.g. other heating and current drive systems or diagnostics. The work addresses the interfaces between the port plug and the blanket considering the helium-cooled pebble bed and the water cooled lithium lead which are two of four breeding blanket concepts under investigation in Europe within the Power Plant Physics and Technology Programme: the required openings will be evaluated in terms of their impact onto the

  13. Expandable gastric port for natural orifice translumenal endoscopic surgery.

    Science.gov (United States)

    Hashiba, Kiyoshi; Siqueira, Pablo R; Brasil, Horus A; Moribe, Daniel; D'Assunção, Marco Aurélio

    2010-09-01

    The risk of intraabdominal contamination is a critical consideration during most natural orifice translumenal endoscopic surgery (NOTES) procedures. The objective of this study was to determine a safe and efficient pathway for the endoscope in a transgastric NOTES procedure. A pilot experimental study in live pigs was performed. Five White Landrace pigs, weighing approximately 30-35 kg, underwent the placement of a device consisting of an expandable sheath, the distal portion of which was composed of a fully covered self-expanding metal stent, and an introducer made with an outer catheter, a pushing catheter, and an inner, guiding catheter. The sheath was attached to the stent by suturing it in place. The initial gastric opening was made by means of a needle knife papilotome with electrocoagulation, aimed to the anterior gastric wall. Then, it was dilated with an endoscopic 1.8-cm balloon. The set was introduced over a Savary guidewire. After the set placement, the outer tube was slowly retrieved. Finally, the delivery system was removed from the pig, leaving the entire endoscopic port in place. The expandable gastric port was placed without difficulty in all animals. Endoscope insertion into the expandable gastric port was very easily performed. The endoscope had a wide range of movement inside the peritoneal cavity. The gastric port sealed the gastric wall, avoiding gross contamination of the peritoneal cavity and maintaining the pneumoperitoneum without excessive inflation of the intestine. Use of a gastric port can minimize contamination of the peritoneal cavity due to the spillage of gastric contents during a transgastric NOTES procedure and can also facilitate performance of the procedure.

  14. Šport in humanistika

    Directory of Open Access Journals (Sweden)

    Jože Vogrinc

    2012-07-01

    Full Text Available O tem, ali je šport »neresen« pojav ali pojav, ki razkriva bistvene razsežnosti tistega, za kar človeku gre, se pogledi razhajajo. Glede na to, da so humanistične študije športa vsaj na prvi pogled nekje na obrobju ved, ki jih združuje Filozofska fakulteta, bi morda veljalo, da ga ne moremo primerjati z globoko resnimi temami, zlasti pa ne z najnovejšimi resnimi zahtevami, ki jih družba postavlja univerzi in znanostim: pripomoči k višji donosnosti in poslovnosti podjetništva ter ohranjati tradicijo in krepiti življenjsko moč naroda. Pa se že pri tem izkaže, da športa ne gre preveč zapostavljati; po eni strani je že nekaj desetletij, kar je postal izjemno kapitalsko zanimivo in donosno področje, v katero podjetniki bodisi vlagajo, da bi dosegali dobičke, bodisi ga podpirajo, da bi z njegovo pomočjo svoje blago povzdignili v simbol pravilno naravnanega načina življenja; po drugi strani pa je tradicija nacionalne pomembnosti vrhunskih športnih izidov in dosežkov le nekaj krajša od drugih načinov mednarodnega uveljavljanja naroda, pomen športnih dosežkov za dokazovanje življenjske moči naroda pa se lahko kosa s pomenom lestvic, kakršne izdajajo mednarodne finančne ustanove o državah, ali lestvic, na katerih najdemo univerze, razvrščene po njihovi pedagoški in znanstveni moči. Pomembnost športa pa podčrtavajo tudi tisti, ki ga ostro kritizirajo in njegovo sodobno vrhunsko različico odklanjajo kot obliko alienacije, manipulacije in ideologije, saj prav športni spektakularizaciji pripisujejo najvišjo napetost, največji pomen in najotipljivejšo moč nad ljudmi, ki bi se morali bojevati za spremembo svojega družbenega položaja in prevrat v vsej družbeni strukturi, pa jih razvedrila, med katerimi ima šport posebej visoko mesto, uspavajo in pomirjajo prav s tem, da njihovo napetost sproščajo v nenevaren odliv socialne energije. Tega kritičnega vidika sodobnega športa ne kaže omejiti zgolj na vrhunski

  15. Norway/United States Design Protective Aircraft Shelter (PAS) Quantity-Distance Program 1/3-Scale Test Series. Volume 3. Appendix B: PAS-3

    Science.gov (United States)

    1993-08-01

    38939 20350 50078 23.98 432 -2827 17753 20204 61.49 433 -2390 20698 22654 66.02 434 -3187 20337 22665 63.80 435 -1394 16189 18152 63.10 436 -278 17324...3232 15668 18614 57.32 443 32.4 -2677 9694 13569 45.59 444 35.5 -2231 9104 12836 45.18 435 41.4 -1394 16189 18152 63.10 436 43.2 -278 17324 18721 67.73...319.87 435 41.4 -1394 16189 18152 63.10 209 PAS- 3 CONCRETE DEBRIS COLLECTION SURVEY SORTED BY RANGE COORDINATES FROM GZ: I.D. MARK WEIGHT X Y RANGE

  16. Efficiency of small wind generator powered water pumping systems; Rendimento de unidade de bombeamento de agua acionada por gerador eolico de pequeno porte

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Mendeleyev Guerreiro; Carvalho, Paulo Cesar Marques de; Costa, Levy Ferreira [Universidade Federal do Ceara (UFC), Fortaleza, CE (Brazil). Dept. de Engenharia Eletrica; Borges Neto, Manuel Rangel [Centro Federal de Educacao Tecnologica de Petrolina (CEFET), PE (Brazil)

    2008-07-01

    The present paper aims to evaluate the efficiency of a small wind generator powered water pumping system; the generator is a permanent magnet generator of 1 kw of axial flow, using three fiber glass blades with 2.46 m diameter. The used centrifugal pump is connected to a 0.5 c v motor, three-phase, frequency of 60 Hz, rotational speed of 3450 rpm. For the efficiency evaluation a shell anemometer, a flow and pressure sensor were used, connected to a data logger to the collection and storage of the data. An energy analyzer was also used to collect the current, voltage and power generated from the wind generator. (author)

  17. Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain.

    Science.gov (United States)

    Harley, Carol A; Starek, Greg; Jones, David K; Fernandes, Andreia S; Robertson, Gail A; Morais-Cabral, João H

    2016-08-30

    The human human ether-à-go-go-related gene (hERG) potassium channel plays a critical role in the repolarization of the cardiac action potential. Changes in hERG channel function underlie long QT syndrome (LQTS) and are associated with cardiac arrhythmias and sudden death. A striking feature of this channel and KCNH channels in general is the presence of an N-terminal Per-Arnt-Sim (PAS) domain. In other proteins, PAS domains bind ligands and modulate effector domains. However, the PAS domains of KCNH channels are orphan receptors. We have uncovered a family of positive modulators of hERG that specifically bind to the PAS domain. We generated two single-chain variable fragments (scFvs) that recognize different epitopes on the PAS domain. Both antibodies increase the rate of deactivation but have different effects on channel activation and inactivation. Importantly, we show that both antibodies, on binding to the PAS domain, increase the total amount of current that permeates the channel during a ventricular action potential and significantly reduce the action potential duration recorded in human cardiomyocytes. Overall, these molecules constitute a previously unidentified class of positive modulators and establish that allosteric modulation of hERG channel function through ligand binding to the PAS domain can be attained.

  18. Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.

    Science.gov (United States)

    Partch, Carrie L; Gardner, Kevin H

    2011-05-10

    Hypoxia-inducible factor (HIF) is the key transcriptional effector of the hypoxia response in eukaryotes, coordinating the expression of genes involved in oxygen transport, glycolysis, and angiogenesis to promote adaptation to low oxygen levels. HIF is a basic helix-loop-helix (bHLH)-PAS (PER-ARNT-SIM) heterodimer composed of an oxygen-labile HIF-α subunit and a constitutively expressed aryl hydrocarbon receptor nuclear translocator (ARNT) subunit, which dimerize via basic helix-loop-helix and PAS domains, and recruit coactivators via HIF-α C-terminal transactivation domains. Here we demonstrate that the ARNT PAS-B domain provides an additional recruitment site by binding the coactivator transforming acidic coiled-coil 3 (TACC3) in a step necessary for transcriptional responses to hypoxia. Structural insights from NMR spectroscopy illustrate how this PAS domain simultaneously mediates interactions with HIF-α and TACC3. Finally, mutations on ARNT PAS-B modulate coactivator selectivity and target gene induction by HIF in vivo, demonstrating a bifunctional role for transcriptional regulation by PAS domains within bHLH-PAS transcription factors.

  19. Treatment of chronic subdural hematomas with subdural evacuating port system placement in the intensive care unit: evolution of practice and comparison with bur hole evacuation in the operating room.

    Science.gov (United States)

    Flint, Alexander C; Chan, Sheila L; Rao, Vivek A; Efron, Allen D; Kalani, Maziyar A; Sheridan, William F

    2017-12-01

    OBJECTIVE The aims of this study were to evaluate a multiyear experience with subdural evacuating port system (SEPS) placement for chronic subdural hematoma (cSDH) in the intensive care unit at a tertiary neurosurgical center and to compare SEPS placement with bur hole evacuation in the operating room. METHODS All cases of cSDH evacuation were captured over a 7-year period at a tertiary neurosurgical center within an integrated health care delivery system. The authors compared the performance characteristics of SEPS and bur hole placement with respect to recurrence rates, change in recurrence rates over time, complications, length of stay, discharge disposition, and mortality rates. RESULTS A total of 371 SEPS cases and 659 bur hole cases were performed (n = 1030). The use of bedside SEPS placement for cSDH treatment increased over the 7-year period, from 14% to 80% of cases. Reoperation within 6 months was higher for the SEPS (15.6%) than for bur hole drainage (9.1%) across the full 7-year period (p = 0.002). This observed overall difference was due to a higher rate of reoperation during the same hospitalization (7.0% for SEPS vs 3.2% for bur hole; p = 0.008). Over time, as the SEPS procedure became more common and modifications of the SEPS technique were introduced, the rate of in-hospital reoperation after SEPS decreased to 3.3% (p = 0.02 for trend), and the difference between SEPS and bur hole recurrence was no longer significant (p = 0.70). Complications were uncommon and were similar between the groups. CONCLUSIONS Overall performance characteristics of bedside SEPS and bur hole drainage in the operating room were similar. Modifications to the SEPS technique over time were associated with a reduced reoperation rate.

  20. Les relations ville-port à Rio de Janeiro : entre difficultés et perspectives de développement As relações cidade-porto no Rio de Janeiro: entre dificuldades e perspectivas de desenvolvimento City-port relationships in Rio de Janeiro: development´s problems and prospects

    Directory of Open Access Journals (Sweden)

    Bertrand Cozic

    2012-06-01

    Full Text Available La réorganisation productive à l’œuvre depuis le début des années 70 projette chaque fois un peu plus les villes et les ports comme des acteurs majeurs de l’intégration des territoires dans les flux issus de la mondialisation. A Rio de Janeiro, depuis la fin des années 90,  nous observons de nombreuses initiatives de modernisation du système portuaire et de revitalisation des friches portuaires de la ville. Le port est actuellement très dynamique au niveau national dans le domaine des conteneurs, des véhicules (roll-on/roll-off, du pétrole et de ses dérivés (port d’appui logistique de la Petrobras et enfin du tourisme avec le transport de passagers. Cependant, les relations ville-port à Rio de Janeiro sont caractérisées par de sérieuses difficultés. Jusqu’à présent, les autorités portuaires, la ville, les acteurs privés et la société civile n’ont pas réussi à formuler un véritable projet de développement concerté autour de la ville et du port.Les relations ville-port à Rio de Janeiro sont encore très fortement influencées par des pratiques issues de l’ère industrielle du pays, présentant les deux entités comme incompatibles. D’un côté, la ville cherche à revitaliser ses friches portuaires en développant de grands projets urbains à vocation touristique sur le modèle de nombreuses expériences internationales ; de l’autre, le port cherche à développer ses activités pour faire face aux flux croissants issus de la mondialisation. Pourtant, de véritables politiques de développement innovantes sont expérimentées à travers le monde, comme c’est le cas en Europe dans les villes portuaires de la « rangée Nord » (Northern Range ou encore en Espagne, ou nous assistons au développement conjoint des deux dynamiques à travers l’élaboration de stratégies économiques concertées.     A reorganização produtiva em curso desde o inicio da década de 70 projeta cada vez mais as

  1. TRENDS IN CONTEMPORARY PORT SERVICES MARKETS

    Directory of Open Access Journals (Sweden)

    Hanna Klimek

    2014-12-01

    Full Text Available This article describes the issues associated with functioning of contemporary seaport services markets. The growth of international supply chains, technical progress and the integration processes in shipping, growth of containerization, increasing competition in the seaport services markets and environmental protection regulations make it necessary for port service providers to adapt to the changing expectations and requirements of their customers, both shippers and, especially maritime, carriers. Thus, the activities they undertake are associated with making investments to ensure an adequate capacity to handle cargo, passengers and means of transport, required quality of service, but also with appropriate organization of port supply centres and lead to an improvement of their competitiveness. Both the factors associated with the external and internal environment of seaports affect the changes in the relationship between the supply and demand on port services markets. Contemporary port services markets are characterized by certain phenomena which can be a sign of their adaptation and development. The aim of this article is to present the essence of the port services market and its relationship with the environment, which subject to rapid and significant changes, creates new conditions for the operation of port supply centres and the entire port services market.

  2. Unique and cross-reactive T cell epitope peptides of the major Bahia grass pollen allergen, Pas n 1.

    Science.gov (United States)

    Etto, Tamara; de Boer, Carmela; Prickett, Sara; Gardner, Leanne M; Voskamp, Astrid; Davies, Janet M; O'Hehir, Robyn E; Rolland, Jennifer M

    2012-01-01

    Bahia grass pollen (BaGP) is a major cause of allergic rhinitis. Subcutaneous allergen-specific immunotherapy is effective for grass pollen allergy, but is unsuitable for patients with moderate to severe asthma due to the risk of anaphylaxis. T cell-reactive but IgE nonreactive peptides provide a safer treatment option. This study aimed to identify and characterize dominant CD4(+) T cell epitope peptides of the major BaGP allergen, Pas n 1. Pas n 1-specific T cell lines generated from the peripheral blood of BaGP-allergic subjects were tested for proliferative and cytokine response to overlapping 20-mer Pas n 1 peptides. Cross-reactivity to homologous peptides from Lol p 1 and Cyn d 1 of Ryegrass and Bermuda grass pollen, respectively, was assessed using Pas n 1 peptide-specific T cell clones. MHC class II restriction of Pas n 1 peptide T cell recognition was determined by HLA blocking assays and peptide IgE reactivity tested by dot blotting. Three Pas n 1 peptides showed dominant T cell reactivity; 15 of 18 (83%) patients responded to one or more of these peptides. T cell clones specific for dominant Pas n 1 peptides showed evidence of species-specific T cell reactivity as well as cross-reactivity with other group 1 grass pollen allergens. The dominant Pas n 1 T cell epitope peptides showed HLA binding diversity and were non-IgE reactive. The immunodominant T cell-reactive Pas n 1 peptides are candidates for safe immunotherapy for individuals, including those with asthma, who are allergic to Bahia and possibly other grass pollens. Copyright © 2012 S. Karger AG, Basel.

  3. Towards Sustainable ASEAN Port Development: Challenges and Opportunities for Vietnamese Ports

    Directory of Open Access Journals (Sweden)

    Saeyeon Roh

    2016-06-01

    Full Text Available Sustainability agendas are challenging port authorities around the world to find ways of operating and managing their ports efficiently and effectively in terms of economic, social, as well as environmental development. In this respect, governments in ASEAN countries have been implementing various green activities seeking to reduce the environmental impact of shipping and related activities. In this connection, most studies in the existing literature mainly focus on the environmental aspects of sustainable development and have not clearly explained what sustainable port development exactly entails. Furthermore, most of these studies emphasized on the impact of port development and overlooked what factors influence sustainable port development. To address these gaps, this research aim to explore the main factors shaping sustainable port development. This was conducted through a comprehensive review of related literature as well as confirmatory in-depth interviews with port authorities. As a result, findings from this research would help identify key elements of sustainable port development from port authorities’ perspective. The challenges, opportunities and managerial implications for Vietnamese ports are also discussed accordingly.

  4. Stakeholder identification of advanced technology opportunities at international ports of entry

    Energy Technology Data Exchange (ETDEWEB)

    Parker, S.K. [Sandia National Labs., Albuquerque, NM (United States). Energy Policy and Planning Dept.; Icerman, L. [Icerman and Associates, Santa Fe, NM (United States)

    1997-01-01

    As part of the Advanced Technologies for International and Intermodal Ports of Entry (ATIPE) Project, a diverse group of stakeholders was engaged to help identify problems experienced at inland international border crossings, particularly those at the US-Mexican border. The fundamental issue at international ports of entry is reducing transit time through the required documentation and inspection processes. Examples of other issues or problems, typically manifested as time delays at border crossings, repeatedly mentioned by stakeholders include: (1) lack of document standardization; (2) failure to standardize inspection processes; (3) inadequate information and communications systems; (4) manual fee and tariff collection; (5) inconsistency of processes and procedures; and (6) suboptimal cooperation among governmental agencies. Most of these issues can be addressed to some extent by the development of advanced technologies with the objective of allowing ports of entry to become more efficient while being more effective. Three categories of technologies were unambiguously of high priority to port of entry stakeholders: (1) automated documentation; (2) systems integration; and (3) vehicle and cargo tracking. Together, these technologies represent many of the technical components necessary for pre-clearance of freight approaching international ports of entry. Integration of vehicle and cargo tracking systems with port of entry information and communications systems, as well as existing industry legacy systems, should further enable border crossings to be accomplished consistently with optimal processing times.

  5. Existence Conditions and Formation Process of Second Type of Spiral Loop Particle Accumulation Structure (SL-2 PAS) in Half-zone Liquid Bridge

    Science.gov (United States)

    Toyama, A.; Gotoda, M.; Kaneko, T.; Ueno, I.

    2017-08-01

    We focus on unique phenomena known as particle accumulation structure (PAS), especially on the conditions of the existence for second-type spiral loop PAS (SL-2 PAS) and on their formation processes under normal gravity. We investigate the existence conditions as functions the aspect ratio of the liquid bridge and the Marangoni number, the intensity of the thermocapillary effect. We discuss the differences among SL-1 PAS, SL-2 PAS and the flow field without PAS through observation of the solid-like structures of the PAS in a rotating frame of reference with the hydrothermal wave, and through monitoring of the surface temperature by infrared camera. We evaluate the formation time of PAS by employing a modified accumulation measure by considering the effect of the particles' size.

  6. Aerial Port of Embarkation Capability Planning. Volume 1.

    Science.gov (United States)

    1983-09-01

    NUMBER 2. GOVT ACCESSION NO. 3. RECIPIENT’S CATALOG NUMBER LSSR 62-83 .- - 4. TITLE (and Subtitle) S. TYPE OF REPORT & PERIOD COVERED AERIAL PORT OF...Integrated Network (WIN) capability to access the Joint Operations Planning System (JOPS) (Appendix B). They also do not have ready access to MAC or MTMC...sensitivity because during adverse weather units may need to turn vehicles into washing early which would increase demand for base transportaion . For the

  7. A Carbon Emission Evaluation for an Integrated Logistics System—A Case Study of the Port of Shenzhen

    Directory of Open Access Journals (Sweden)

    Lei Yang

    2017-03-01

    Full Text Available The port is an important node in logistics, and its energy consumption constitutes a considerable proportion of the transportation industry. In port logistics, not only does the energy consumption generate carbon emissions, but other business activities do as well. This paper firstly characterizes the sources of carbon emissions and the basic elements in the port system, and proposes the concept of a port-integrated logistics system. Secondly, a case study of The Port of Shenzhen is conducted and a method is provided to measure the carbon emissions in the port-integrated logistics system. This paper then suggests two approaches to reducing carbon emissions, and their economic and environmental benefits are compared. Finally, some policies are put forward to reduce carbon emissions, such as improving the efficiency of loading and unloading, and replacing the heavy fuel oil by low sulfur fuel oil and shore power. The proposed method of carbon emission reduction for port-integrated logistics systems can be generalized for the analysis of various types of ports.

  8. Complications of an implantable venous access device (Port-a-Cath) during intermittent continuous infusion of chemotherapy

    NARCIS (Netherlands)

    Poorter, R. L.; Lauw, F. N.; Bemelman, W. A.; Bakker, P. J.; Taat, C. W.; Veenhof, C. H.

    1996-01-01

    In 149 patients, treated with intermittent continuous infusion of different chemotherapeutic agents, 169 Port-a-Caths were implanted by qualified surgeons and residents in training. The peri- and postoperative complications of implantation of the Port-a-Cath system and the complications during

  9. Visible and Infrared Optical Design for the ITER Upper Ports

    Energy Technology Data Exchange (ETDEWEB)

    Lasnier, C; Seppala, L; Morris, K; Groth, M; Fenstermacher, M; Allen, S; Synakowski, E; Ortiz, J

    2007-03-01

    This document contains the results of an optical design scoping study of visible-light and infrared optics for the ITER upper ports, performed by LLNL under contract for the US ITER Project Office. ITER is an international collaboration to build a large fusion energy tokamak with a goal of demonstrating net fusion power for pulses much longer than the energy confinement time. At the time of this report, six of the ITER upper ports are planned to each to contain a camera system for recording visible and infrared light, as well as other diagnostics. the performance specifications for the temporal and spatial resolution of this system are shown in the Section II, Functional Specifications. They acknowledge a debt to Y. Corre and co-authors of the CEA Cadarache report ''ITER wide-angle viewing and thermographic and visible system''. Several of the concepts used in this design are derived from that CEA report. The infrared spatial resolution for optics of this design is diffraction-limited by the size of the entrance aperture, at lower resolution than listed in the ITER diagnostic specifications. The size of the entrance aperture is a trade-off between spatial resolution, optics size in the port, and the location of relay optics. The signal-to-noise ratio allows operation at the specified time resolutions.

  10. The effect of pyrrolizidine alkaloids (Senecio vulgaris) on the liver mixed-funcion oxidase system.

    Science.gov (United States)

    Eastman, D F; Segall, H J

    1980-05-01

    A model system to detect the toxicity of pyrrolizidine alkaloids (PAs) was explored. Using the liver S-10 fraction, the effect of PAs on aniline hydroxylase and aminopyrine N-demethylase was examined. PAs were toxic to the aminopyrine N-demethylase enzyme system while exerting no toxicity on the aniline hydroxylase enzyme system.

  11. Simulating storm surge inundation and damage potential within complex port facilities

    Science.gov (United States)

    Mawdsley, Robert; French, Jon; Fujiyama, Taku; Achutan, Kamalasudhan

    2017-04-01

    Storm surge inundation of port facilities can cause damage to critical elements of infrastructure, significantly disrupt port operations and cause downstream impacts on vital supply chains. A tidal surge in December 2013 in the North Sea partly flooded the Port of Immingham, which handles the largest volume of bulk cargo in the UK including major flows of coal and biomass for power generation. This flooding caused damage to port and rail transport infrastructure and disrupted operations for several weeks. This research aims to improve resilience to storm surges using hydrodynamic modelling coupled to an agent-based model of port operations. Using the December 2013 event to validate flood extent, depth and duration, we ran a high resolution hydrodynamic simulation using the open source Telemac 2D finite element code. The underlying Digital Elevation Model (DEM) was derived from Environment Agency LiDAR data, with ground truthing of the flood defences along the port frontage. Major infrastructure and buildings are explicitly resolved with varying degrees of permeability. Telemac2D simulations are run in parallel and take only minutes on a single 16 cpu compute node. Inundation characteristics predicted using Telemac 2D differ from a simple Geographical Information System 'bath-tub' analysis of the DEM based upon horizontal application of the maximum water level across the port topography. The hydrodynamic simulation predicts less extensive flooding and more closely matches observed flood extent. It also provides more precise depth and duration curves. Detailed spatial flood depth and duration maps were generated for a range of tide and surge scenarios coupled to mean sea-level rise projections. These inundation scenarios can then be integrated with critical asset databases and an agent-based model of port operation (MARS) that is capable of simulating storm surge disruption along wider supply chains. Port operators are able to act on information from a particular

  12. Algorithms for Port-of-Entry Inspection

    National Research Council Canada - National Science Library

    Roberts, Fred S

    2007-01-01

    .... The percentage at some ports has now risen to 6%, but this is still a very small percentage. The purpose of this project was to develop decision support algorithms that help to optimally intercept illicit materials and weapons...

  13. Public Port Finance Survey for FY 2006

    Science.gov (United States)

    2008-12-01

    This report is the result of a cooperative effort between the Maritime Administration and : the American Association of Port Authorities (AAPA). It was prepared by the Maritime : Administration, using financial information furnished by AAPA. : This i...

  14. NMFS Menhaden Biostatistical (Port Samples) Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data set consists of port samples of gulf and Atlantic menhaden from the reduction purse-seine fisheries: data include specimen fork length, weight and age (yrs), as...

  15. Port: arstid kasutavad narkootikume / Marina Lohk

    Index Scriptorium Estoniae

    Lohk, Marina

    2015-01-01

    Tallinna ülikooli terviseteaduste ja spordi instituudi direktor ja spordibioloog Kristjan Port mainis ETV saates "Vabariigi kodanikud", et töövõime taastamiseks kasutatakse sageli narkootilisi aineid ning seda teevad ka arstid. Kristjan Porti selgitused

  16. Grain operator miffed at port administration

    Index Scriptorium Estoniae

    2006-01-01

    Ventspils Grain Terminal saatis president Vaira Vike-Freibergale ja mitmetele ministritele kirja sõnumiga, et Ventspilsi Vabasadama (Ventspils Free Port) administratsiooni tegevus takistab terminali äritegevust

  17. Port Authority of Allegheny County Transit Stops

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — All transit stops within the Port Authority of Allegheny County's service area for the November 20, 2016 - March (TBD) 2017 schedule period.

  18. Standardized staining methods: Feulgen-Rossenbeck reaction for desoxyribonucleic acid and periodic acid-Schiff (PAS) procedure

    DEFF Research Database (Denmark)

    Lyon, H O; Schulte, E K; Prento, P

    2002-01-01

    A project group working under the European Confederation of Laboratory Medicine (ECLM) presents recommendations for standardized procedures for the Feulgen-Rossenbeck-Schiff and the periodic acid-Schiff (PAS) reactions on cytological and histological material. The advantages and disadvantages...

  19. Les ports commerciaux d’Afrique du Sud

    OpenAIRE

    Marie-Annick Lamy-Giner

    2005-01-01

    South Africa’s seaboard comprises seven commercial ports. In this study, six choremes have been constructed, taking account of historical factors, the nature of the hinterlands, differences between the port cities, relations with the foreland and the port hierarchy. This graphic representation provides a better understanding of the development, role and port functions of South Africa in economic transition.

  20. An Analysis of Port Service Quality and Customer Satisfaction: The Case of Korean Container Ports

    Directory of Open Access Journals (Sweden)

    Gi Tae Yeo

    2015-12-01

    Full Text Available Ports play a critical role in the economy of many countries and regions. Failure or unreliability of port services can significantly influence port customers—shipping lines and cargo owners—and result in their dissatisfaction. However, what constitutes port service quality (PSQ and its influence on the satisfaction of port customers has not been well investigated in the literature. Therefore, this study investigates the concept of PSQ and its influence on customer satisfaction in the case of Korean container ports. Following a literature review, a conceptual model of PSQ and its influence on customer satisfaction is proposed. The model was validated through a survey of 313 members of the Korean Port Logistics Association (KPLA. Partial least squares structural equation modeling (PLS-SEM was conducted to confirm the PSQ dimensions and to examine their relationship with customer satisfaction using SmartPLS 3.2.1 software. PSQ is found to be a five-factor construct, and its management, and image and social responsibility factors have significant positive effects on customer satisfaction. In addition to its academic contribution, this study also contributes to management practices because port managers can use the PSQ scale to measure their customers’ satisfaction and justify investments in the quality management of port services.

  1. Occupational hazards to health of port workers.

    Science.gov (United States)

    Wang, Yukun; Zhan, Shuifen; Liu, Yan; Li, Yan

    2017-12-01

    The aim of this article is to reduce the risk of occupational hazards and improve safety conditions by enhancing hazard knowledge and identification as well as improving safety behavior for freight port enterprises. In the article, occupational hazards to health and their prevention measures of freight port enterprises have been summarized through a lot of occupational health evaluation work, experience and understanding. Workers of freight port enterprises confront an equally wide variety of chemical, physical and psychological hazards in production technology, production environment and the course of labor. Such health hazards have been identified, the risks evaluated, the dangers to health notified and effective prevention measures which should be put in place to ensure the health of the port workers summarized. There is still a long way to go for the freight port enterprises to prevent and control the occupational hazards. Except for occupational hazards and their prevention measures, other factors that influence the health of port workers should also be paid attention to, such as age, work history, gender, contraindication and even the occurrence and development rules of occupational hazards in current production conditions.

  2. Economic and geographic backgrounds of land reclamation in Japanese ports.

    Science.gov (United States)

    Suzuki, Takeshi

    2003-01-01

    Under the present legal system, environmental impacts are usually assessed on condition that reclamation plans are given clearly. Although impact magnitude depends on reclamation scales, the economic and geographic backgrounds of reclamation scales have been rarely analyzed. Hence, properties of reclamation in port districts were investigated. The long-term trend showed that the area newly reclaimed per year has decreased rapidly since the first oil crisis; while the speed of the decrease dropped after 1984. The distributions of increased reclamation area planned against its water depth had one or two peaks in 1989-1991 and 1996-1998. These peaks resulted mainly from "island-type" reclamation, and shifted from shallow to deep sites. The areas of port districts had major effects on increased area of reclamation and maximum water depth in 1989-1991, while such effects were not observed in 1996-1998. Land price had some effects for deepening water depth of reclamation in both periods.

  3. Radiologic placement of implantable chest ports in pediatric patients under sedation

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Tae Beom [Dong-A University School of Medicine, Pusan (Korea, Republic of)

    2003-08-01

    To evaluate the safety and efficacy of the radiologic placement of implantable chest ports under intravenous sedation in pediatric patients with malignancy. Between October 2001 and June 2002, 20 chest ports were placed in 19 pediatric patients [13 boys and six girls aged 1-11 (mean, 4.7) years] for the purpose of long-term chemotherapy. In three patients, tunneled central venous catheters had been removed because of catheter extration, infection, and tearing. Under intravenous sedation, the right internal jugular vein was used for access in 19 cases, and the left internal jugular vein in one. Venipucture was performed using a micropuncture needle with real-time ultrasound guidance. A port chamber was created at the infraclavicular fossa, and to prevent catheter kinking, a smooth-angled tunnel was created between the venipuncture site and the subcutaneous pocket. The catheter tip was positioned under fluoroscopy at the junction of the superior vena cava and right atrium. We observed technical success, complications arouse during and after the procedure, and duration of catheter use. Implantation of the port system was successful in all cases, though slight hematoma, treated with manual compression, occurred at a chamber pocket in one case. In addition, the port system was removed from one patient because of wound infection leading to dehiscence and catheter malpositiong. A new port system was implanted through the left internal jugular vein. The median period during which catheter use was followed up was 118 (range, 18-274) days. For long-term chemotherapy in pediatric patients with malignancy, radiologic placement of an implantable chest port under intravenous sedation shows a high technical success rate, with few complications. This method may thus be used instead of surgical port placement.

  4. Combined ultrasound and fluoroscopy guided port catheter implantation-High success and low complication rate

    Energy Technology Data Exchange (ETDEWEB)

    Gebauer, Bernhard [Department of Radiology, Charite, Universitaetsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin (Germany)], E-mail: bernhard.gebauer@charite.de; El-Sheik, Michael [Department of Diagnostic Radiology, University Hospital, Philipps University Marburg, Baldingerstrasse, 35033 Marburg (Germany); Department of Radiology, Vivantes, Hospital Friedrichshain, Am Urban, Hellersdorf and prenzlauer Berg, Landsberger Allee 49, 10249 Berlin (Germany); Vogt, Michael [Department of Diagnostic Radiology, University Hospital, Philipps University Marburg, Baldingerstrasse, 35033 Marburg (Germany); Wagner, Hans-Joachim [Department of Diagnostic Radiology, University Hospital, Philipps University Marburg, Baldingerstrasse, 35033 Marburg (Germany); Department of Radiology, Vivantes, Hospital Friedrichshain, Am Urban, Hellersdorf and prenzlauer Berg, Landsberger Allee 49, 10249 Berlin (Germany)

    2009-03-15

    Purpose: To evaluate peri-procedural, early and late complications as well as patients' acceptance of combined ultrasound and fluoroscopy guided radiological port catheter implantation. Materials and methods: In a retrospective analysis, all consecutive radiological port catheter implantations (n = 299) between August 2002 and December 2004 were analyzed. All implantations were performed in an angio suite under analgosedation and antibiotic prophylaxis. Port insertion was guided by ultrasonographic puncture of the jugular (n = 298) or subclavian (n = 1) vein and fluoroscopic guidance of catheter placement. All data of the port implantation had been prospectively entered into a database for interventional radiological procedures. To assess long-term results, patients, relatives or primary physicians were interviewed by telephone; additional data were generated from the hospital information system. Patients and/or the relatives were asked about their satisfaction with the port implantion procedure and long-term results. Results: The technical success rate was 99% (298/299). There were no major complications according to the grading system of SIR. A total of 23 (0.33 per 1000 catheter days) complications (early (n = 4), late (n = 19)) were recorded in the follow-period of a total of 72,727 indwelling catheter days. Infectious complications accounted for 0.15, thrombotic for 0.07 and migration for 0.04 complications per 1000 catheter days. Most complications were successfully treated by interventional measures. Twelve port catheters had to be explanted due to complications, mainly because of infection (n = 9). Patients' and relatives' satisfaction with the port catheter system was very high, even if complications occurred. Conclusion: Combined ultrasound and fluoroscopy guided port catheter implantation is a very safe and reliable procedure with low peri-procedural, early and late complication rate. The intervention achieves very high acceptance by the

  5. Le big bang n'est pas une théorie comme les autres

    CERN Document Server

    Bonnet-Bidaud, Jean-Marc; Leglu, Dominique; Reinisch, Gilbert

    2009-01-01

    Le big bang n'est pas une théorie comme les autres. Ce n'est d'ailleurs pas une théorie physique au sens propre du terme, mais un scénario cosmologique issu des équations de la relativité générale. Il est le modèle qui s'ajuste le mieux aux observations actuelles, mais à quel prix ? Il nous livre un Univers composé à 96 % de matière et d'énergie noires inconnues. C'est donc un euphémisme que de dire que le big bang semble poser autant - sinon plus - de questions qu'il n'en résout. En ce sens, le big bang apparaît davantage comme une paramétrisation de notre ignorance plutôt que comme une modélisation d'un phénomène. Pourtant, le succès du big bang et l'adhésion qu'il suscite, tant dans la sphère scientifique que dans la sphère médiatique, ne se démentent pas. Surmédiatisé, son statut dépasse celui de modèle théorique, et la simple évocation de son nom suffit pour justifier des opérations de marketing scientifique ou rejeter des cosmologies alternatives. Pour éclaircir les pr...

  6. Second Annual Maintenance, Inspection, and Test Report for PAS-1 Cask Certification for Shipping Payload B

    Energy Technology Data Exchange (ETDEWEB)

    KELLY, D.J.

    2000-10-09

    The Nuclear Packaging, Inc. (NuPac), PAS-1 cask is required to undergo annual maintenance and inspections to retain certification in accordance with U.S. Department of Energy (DOE) Certificate of Compliance USA/9184B(U) (Appendix A). The packaging configuration being tested and maintained is the NuPac PAS-1 cask for Payload B. The intent of the maintenance and inspections is to ensure the packaging remains in unimpaired physical condition. Two casks, serial numbers 2162-026 and 2162-027, were maintained, inspected, and tested at the 306E Development, Fabrication, and Test Laboratory, located at the Hanford Site's 300 Area. Waste Management Federal Services, Inc. (WMFS), a subsidiary of GTS Duratek, was in charge of the maintenance and testing. Cogema Engineering Corporation (Cogema) directed the operations in the test facility. The maintenance, testing, and inspections were conducted successfully with both PAS-1 casks. The work conducted on the overpacks included weighing, gasket replacement, and plastic pipe plug and foam inspections. The work conducted on the secondary containment vessel (SCV) consisted of visual inspection of the vessel and threaded parts (i.e., fasteners), visual inspection of sealing surfaces, replacement of O-ring seals, and a helium leak test. The work conducted on the primary containment vessel (PCV) consisted of visual inspection of the vessel and threaded parts (i.e., fasteners), visual inspection of sealing surfaces, replacement of O-ring seals, dimensional inspection of the vessel bottom, a helium leak test, and dye penetrant inspection of the welds. The vermiculite material used in the cask rack assembly was replaced.

  7. Using Indium Tin Oxide To Mitigate Dust on Viewing Ports

    Science.gov (United States)

    2008-01-01

    NASA plans to use a number of onboard viewing ports to measure lunar regolith in situ and to monitor robotic and human activities on the lunar or Martian surface. Because of the size and abundance of dust particles on these bodies, the potential for dust to occlude viewing ports and windows is high enough to threaten system lifetime and reliability, especially when activities rely on relaying video to either a habitat module or controllers on Earth. This project uses a technology being developed by KSC's Electrostatics and Surface Physics Laboratory to remove dust from windowlike surfaces. The technology applies an alternating electric potential to interlaced electrodes. In this application, we use indium tin oxide (ITO) to create various electrode patterns in order to determine the most reliable pattern for dust removal. This technology has application to systems where optical clarity is important. Specifically, this project considers the in situ resource utilization (ISRU) application of a viewing port for Raman spectroscopy, where the electrode pattern on glass would be coated with a scratch-resistant sapphire film (Al2O3).

  8. Spanish validation of the PAS-ADD Checklist Questionnaire for people with intellectual disabilities for Spanish population.

    Science.gov (United States)

    Martorell, A; González, M C; Gutiérrez, P; Rincón, F; Núñez-Polo, M H

    2017-10-01

    The Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD) is an international reference tool for the diagnosis and assessment of mental health problems and behavioural disorders among people with intellectual disabilities. Although the original PAS-ADD instrument has been validated in the Spanish language, the shorter PAS-ADD Checklist has yet not been validated. The aim of this study is to validate the PAS-ADD Checklist for the Spanish population. The PAS-ADD Checklist Questionnaire was administered to 208 adults with intellectual disabilities at a vocational centre in Madrid, Spain. The psychometric analyses included internal consistency, inter-rater and test-retest reliability, Varimax rotation factor analysis for construct validity, criterion validity and feasibility. The Cronbach's alpha was 0.80 for the overall questionnaire and between 0.40 and 0.79 for the subscales. The Kappa coefficients for test-retest and inter-rater reliability were between 0.66 and 0.80. Varimax rotation factor analysis showed five well-defined factors. The Kappa coefficients for criterion validity were between 0.30 and 0.70. Feasibility was also good. The PAS-ADD Checklist is a feasible and reliable instrument for carrying out initial assessment of the mental health status of adults with intellectual disabilities, referring cases to more specialised diagnosis and treatment. © 2017 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

  9. Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Marreilha dos Santos, A.P., E-mail: apsantos@ff.ul.pt [I-Med.UL, Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon (Portugal); Lucas, Rui L.; Andrade, Vanda; Mateus, M. Luísa [I-Med.UL, Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon (Portugal); Milatovic, Dejan; Aschner, Michael [Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Batoreu, M. Camila [I-Med.UL, Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon (Portugal)

    2012-02-01

    Chronic, excessive exposure to manganese (Mn) may induce neurotoxicity and cause an irreversible brain disease, referred to as manganism. Efficacious therapies for the treatment of Mn are lacking, mandating the development of new interventions. The purpose of the present study was to investigate the efficacy of ebselen (Ebs) and para-aminosalicylic acid (PAS) in attenuating the neurotoxic effects of Mn in an in vivo rat model. Exposure biomarkers, inflammatory and oxidative stress biomarkers, as well as behavioral parameters were evaluated. Co-treatment with Mn plus Ebs or Mn plus PAS caused a significant decrease in blood and brain Mn concentrations (compared to rats treated with Mn alone), concomitant with reduced brain E{sub 2} prostaglandin (PGE{sub 2}) and enhanced brain glutathione (GSH) levels, decreased serum prolactin (PRL) levels, and increased ambulation and rearing activities. Taken together, these results establish that both PAS and Ebs are efficacious in reducing Mn body burden, neuroinflammation, oxidative stress and locomotor activity impairments in a rat model of Mn-induced toxicity. -- Highlights: ► The manuscript is unique in its approach to the neurotoxicity of Mn. ► The manuscript incorporates molecular, cellular and functional (behavioral) analyses. ► Both PAS and Ebs are effective in restoring Mn behavioral function. ► Both PAS and Ebs are effective in reducing Mn-induced oxidative stress. ► Both PAS and Ebs led to a decrease in Mn-induced neuro-inflammation.

  10. Metamorfoses da cidade portuária: transformações da relação entre o porto e a cidade de Lisboa Métamorphoses de la ville portuaire: transformations de la relation entre le port et la ville de Lisbonne Port city metamorphosis: transformations of the relationship between the port and the city of Lisbon

    Directory of Open Access Journals (Sweden)

    André Fernandes

    2012-06-01

    dimensões funcional, urbanística e económica e apresenta-se um esquema de base para a definição de um modelo original que identifique, explique e caracterize as grandes fases desta dinâmica relacional.Le processus d´évolution des ports à l´époque moderne a été déterminé par la mutabilité des fonctions portuaires, induite par des facteurs comme les évolutions technologiques des navires, des équipements d´appui à la manipulation des marchandises ou des techniques d´entreposage; les transformations du commerce international, les modifications dans l´organisation des transports maritimes ou l´élargissement et la complexification des chaînes logistiques globales. Comme résultat de ces mutations, nous assistons à un évolution concomittante de la structure, de la morphologie et de l´extension des espaces occupés par des activités portuaires et des activités complémentaires. Dans ce contexte, la relation entre le port et la ville de Lisbonne (Portugal est actuellement marquée par une grande complexité qui met fin à une tradition historique ainsi que par la magnitude et l´intensité d´un processus mettant en jeu la principale infrastructure portuaire nationale et la plus grande ville du pays. Nous notons toutefois que nous passons d´une relation symbiotique ville-port, dans laquelle la ville était polarisatrice d´un système urbain régional et le principal élément de l´intégration nationale dans le réseau urbain de la péninsule ibérique et de l´Europe, à une situation où elle s´autonomize et assume un caractère éminemment généraliste, économiquement diversifié et fonctionnellement complexe. Malgré cette évolution, le port demeure un point nodal de l´intégration de la ville-région dans des systèmes globaux de flux matériels et immatériels. Même étant un élément progressivemment moins intégré à la structure urbaine et fonctionnelle de la ville, le port n´en continue pas moins à marquer la cadence d

  11. [Gardner syndrome--parent alienation syndrome (PAS). Diagnosis or family reality?].

    Science.gov (United States)

    Namysłowska, Irena; Heitzman, Janusz; Siewierska, Anna

    2009-01-01

    The authors present characteristics of Parental Alienation Syndrome (PAS) proposed by Gardner as well as data, which may help to differentiate that syndrome with real psychological, physical and sexual abuse. The consequences of Gardner Syndrome for legal decisions in the court cases of child custody and the critique of this syndrome in forensic and psychiatric literature are also discussed, and several questions posed. Authors propose to treat Gardner Syndrome not as as a child disorder but as a specific, dynamic family situation, which occurs sometimes, during divorce and fight about child custody.

  12. The Self Diagnosis Method. A new methodology to assess environmental management in sea ports.

    Science.gov (United States)

    Darbra, R M; Ronza, A; Casal, J; Stojanovic, T A; Wooldridge, C

    2004-03-01

    A methodology has been designed to assess the performance of the environmental management in sea ports. The Self Diagnosis Method, developed by two research teams and about sixty sea ports, allows the comparison of the current environmental situation with that corresponding to previous years and the assessment of the opportunities for improvement. The main objective is to review the management activities and procedures that affect the environment and the way the port authority handles significant environmental aspects. It has been designed as a "first level" tool: it can be applied in approximately six hours by a non-expert user. It is based on the ISO 14001 vocabulary, requirements and structure, and it can be considered as a first step in the voluntary implementation of an environmental management system for port communities.

  13. Port throughput influence factors based on neighborhood rough sets: An exploratory study

    Directory of Open Access Journals (Sweden)

    Weiping Cui

    2015-11-01

    Full Text Available Purpose: The purpose of this paper is to devise a efficient method for the importance analysis on Port Throughput Influence Factors. Design/methodology/approach: Neighborhood rough sets is applied to solve the problem of selection factors. First the throughput index system is established. Then, we build the attribute reduction model using the updated numerical attribute to reduction algorithm based on neighborhood rough sets. We optimized the algorithm in order to achieve high efficiency performance. Finally, the article do empirical validation using Guangzhou Port throughput and influencing factors’ historical data of year 2000 to 2013. Findings: Through the model and algorithm, port enterprises can identify the importance of port throughput factors. It can provide support for their decisions. Research limitations: The empirical data are historical data of year 2000 to 2013. The amount of data is small. Practical implications: The results provide support for port business investment, decisions and risk control, and also provide assistance for port enterprises’ or other researchers’ throughput forecasting. Originality/value: In this paper, we establish a throughput index system, and optimize the algorithm for efficiency performance.  

  14. Periinterventional prophylactic antibiotics in radiological port catheter implantation; Periinterventionelle prophylaktische Antibiotikagabe bei der radiologischen Portkatheterimplantation

    Energy Technology Data Exchange (ETDEWEB)

    Gebauer, B.; Teichgraeber, U.; Werk, M. [Charite, Universitaetsmedizin Berlin (Germany). Klinik fuer Strahlenheilkunde; Wagner, H.J. [Vivantes Klinikum im Friedrichshain und am Urban (Germany). Inst. fuer Radiologie

    2007-08-15

    Purpose: To evaluate whether catheter-related infections after radiologically placed port catheters can be reduced by single-shot periinterventional antibiosis. Materials and Method: Between January and September 2002, 164 consecutive patients with indication for central venous port catheter implantation were included in the present study. During implantation the interventional radiologist was responsible for deciding whether to administer a prophylactic single-shot antibiosis. The prophylactic antibiosis entailed intravenous administration of ampicillin and sulbactam (3 g Unacid, Pfizer) or 100 mg ciprofloxacine (Ciprobay, Bayer) in the case of an allergy history to penicillins. Catheter-related infection was defined as a local or systemic infection necessitating port catheter extraction. Results: Indication for port catheter implantation was a malignant disease requiring chemotherapy in 158 cases. The port catheter (Chemosite [Tyco Healthcare] [n = 123], low-profile [Arrow International] [n = 35], other port system [n = 6]) was implanted via sonographically guided puncture of the right jugular vein in 139 patients, via the left jugular vein in 24 cases and via the right subclavian vein in one patient. 75 patients received periinterventional prophylactic antibiosis (Unacid [n = 63] Ciprobay [n = 12]) and 89 patients did not receive antibiosis. The prophylactic antibiosis caused a minor allergic reaction in one patient that improved with antihistamic and corticoid medication. A total of 7 ports, 6 without prophylactic antibiosis versus one with periinterventional prophylaxis, were extracted due to infectious complications. Conclusion: Single-shot periinterventional prophylactic antibiosis can reduce early and late infectious complications after radiological-interventional placement of central venous port catheters. (orig.)

  15. Application of Game Theory and Uncertainty Theory in Port Competition between Hong Kong Port and Shenzhen Port

    Directory of Open Access Journals (Sweden)

    Thi Minh Hoang Do

    2015-06-01

    Full Text Available This paper unveils the strong competition in container cargo between Hong Kong Port which has been emerging as an international maritime center since the 1970s and Shenzhen Port which has recently gained remarkable achievements in the Pearl River Delta region. Among various competing strategies, the study focuses on the long-term one in which two ports will decide to compete by investing in capacity. The purpose of this research is to examine their decision making process and to suggest future strategic actions in the current situation. Within its scope, only economic profit brought back from the investment is considered. For this reason, an uncertain payoff two-person game model is developed where an uncertain factor of demand is involved. In applying Uncertainty theory (Liu, 2013, the two methods to solve the game are introduced, including uncertain statistics and the expected Nash Equilibrium strategy. The results obtained from this research generate meaningful suggestions for future competition plan for the two selected ports, which conclude that Shenzhen is the dominant port in this long-term strategy. Compared to existing works on the same topic, the paper shows its distinctiveness by studying the latest competitive situation with regard to the uncertain demand in the game model.

  16. Geologic constraints and speleogenesis of Cova des Pas de Vallgornera, a complex coastal cave from Mallorca Island (Western Mediterranean

    Directory of Open Access Journals (Sweden)

    Joaquín Ginés

    2014-05-01

    Full Text Available The flat areas of eastern and southern Mallorca host a remarkable coastal karst, where Cova des Pas de Vallgornera stands out due to its length (more than 74 km and its special morphological suite. The pattern of the cave is quite heterogeneous showing sharp differences produced by the architecture of the Upper Miocene reef: spongework mazes and collapse chambers dominate in the reef front facies, whereas joint-guided conduits are the rule in the back reef carbonates. Regarding the speleogenesis of the system, a complex situation is envisaged involving three main agents: coastal mixing dissolution, drainage of meteoric diffuse recharge, and hypogene basal recharge related to local geothermal phenomena. The cave system is disposed in two main tiers of passages, of which geomorphologic interpretations are derived from their elevation data. The evolutionary trends as well as the chronology of the different cave sections are difficult to establish owing to the frequent shifting of the coastal base level during the Plio-Quaternary. In this respect, the genesis and evolution of the cave were fully controlled by sea-level fluctuations in the Western Mediterranean basin, with the main phases of cave formation, based on vertebrate paleontological data, going back to mid-Pliocene times.

  17. Sequences that direct subcellular traffic of the Drosophila methoprene-tolerant protein (MET) are located predominantly in the PAS domains.

    Science.gov (United States)

    Greb-Markiewicz, Beata; Orłowski, Marek; Dobrucki, Jerzy; Ożyhar, Andrzej

    2011-10-15

    Methoprene-tolerant protein (MET) is a key mediator of antimetamorphic signaling in insects. MET belongs to the family of bHLH-PAS transcription factors which regulate gene expression and determine essential physiological and developmental processes. The ability of many bHLH-PAS proteins to carry out their functions is related to the patterns of intracellular trafficking, which are determined by specific sequences and indicate that a nuclear localization signal (NLS) or a nuclear export signal (NES) is present and active. Therefore, the identification of NLS and NES signals is fundamental in order to understand the intracellular signaling role of MET. Nevertheless, data on the intracellular trafficking of MET are inconsistent, and until now there hasn't been any data on potential NLS and NES sequences. To analyze the trafficking of MET we designed a number of expression vectors encoding full-length MET, as well as various derivatives, that were fused to yellow fluorescent protein (YFP). Confocal microscopy analysis of the subcellular distribution of YFP-MET indicated that while this protein was localized mainly in the nucleus, it was also observed in the cytoplasm. This suggested the presence of both an NLS and NES in MET. Our work has shown that each of the two PAS domains of MET (PAS-A and PAS-B, respectively) contain one NLS and one NES sequence. Additional NES activity was present in the C-terminal fragment. The NLS activity located in PAS-B was dependent on the presence of juvenile hormone (JH), the potential ligand for MET. In contrast to this, JH didn't seem to be required for the NLS in PAS-A to be active. However, on the basis of current knowledge about the function of PAS-A in other bHLH-PAS proteins, we suggest there might be other proteins that control the activity of the NLS and possibly the NES located in the PAS-A of MET. Thus, the intracellular trafficking of MET seems to be regulated by a rather complicated network of different factors. Copyright

  18. Nuclear analysis of the ITER Cryopump Ports

    Energy Technology Data Exchange (ETDEWEB)

    Moro, Fabio, E-mail: fabio.moro@enea.it [ENEA, Fusion Technical Unit, Nuclear Technologies Laboratory, Via Enrico Fermi 45, 00044 Frascati, Rome (Italy); Villari, Rosaria; Flammini, Davide [ENEA, Fusion Technical Unit, Nuclear Technologies Laboratory, Via Enrico Fermi 45, 00044 Frascati, Rome (Italy); Antipenkov, Alexander; Dremel, Matthias; Levesy, Bruno; Loughlin, Michael [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul-lez-Durance (France); Juarez, Rafael; Perez, Lucia [UNED, Energetic Engineering Department, C/Juan del Rosal 12, Madrid (Spain); Petrizzi, Luigino [European Commission, DG Research & Innovation G5, CDMA 00/030, B-1049 Brussels (Belgium)

    2015-10-15

    Highlights: • Evaluation the shielding effectiveness of the TCPHs by means of 3-D neutrons and gamma maps. • Assessment of the nuclear heating induced by neutron and photons on the TCP and TCPHs. • Calculation of the dose rate at 12 days after shutdown in the maintenance area of the Lower Ports with the Advanced D1S method, in order to verify the design target (100 μSv/h). • Potential improvements of the shielding configuration aimed at the reduction of the dose level in the Port Cell have been proposed and discussed. - Abstract: The ITER machine will be equipped with 6 torus Cryopumps (TCP) that are positioned in their housings (TCPH) and integrated into the cryostat walls at B1 level in the port cells. A comprehensive nuclear analysis of the Cryopump Ports #4 and #12 has been carried out by means of the MCNP-5 Monte Carlo code in a full 3-D geometry, providing guidelines for the design of the embedded components. Radiation transport calculations have been performed in order to determine the radiation field inside the Lower Ports, up the Port Cell: 3-D neutrons and gamma maps have been provided in order to evaluate the shielding effectiveness of the TCPHs. Nuclear heating induced by neutron and photons have been estimated on the TCP and TCPH to assess the nuclear loads during plasma operations. The shutdown dose rate in the maintenance area of the Lower Ports has been assessed with the Advanced D1S method to verify the design limits.

  19. Fossil Crustacea of the Late Pleistocene Port Morant Formation, west Port Morant Harbour, southeastern Jamaica

    NARCIS (Netherlands)

    Collins, J.S.H.; Donovan, S.K.; Stemann, T.A.

    2009-01-01

    The Late Pleistocene Port Morant Formation of southeast Jamaica is particularly rich in fossil marine crustaceans. A new locality on the west side of Port Morant Harbour, parish of St. Thomas, has yielded decapods including the callianassids Lepidophthalmus jamaicense? (Schmitt ), Neocallichirus

  20. Piraterie maritime: pas d’«internationalisation» de la fonction juridictionnelle

    Directory of Open Access Journals (Sweden)

    Jean-Marc Thouvenin

    2013-01-01

    Full Text Available La crise de la piraterie maritime qui a longuement sévi au large de la Somalie est en voie de résorption, mais les pirates n’ont pas cessé leurs ataques qui se produisent désormais dans les eaux de l’Afrique de l’ouest. Pour y faire face, et traduire les pirates en justice, la Communauté internationale s’est rapidement appuyée sur les tribunaux des États de la région, tout en exigeant d’eux le respect des standards du procès équitable ainsi que des droits de l’homme. Elle s’est engagée dans un fort soutien, à la fois technique, financier et juridique, à leur action. Les résultats n’ayant pas été immédiats, l’idée de créer une juridiction internationale, ou internationalisée, a été évoquée par le Conseil de sécurité des Nations Unies. Elle a finalement été rejetée, au profit d’un renforcement de l’action en faveur des processus judiciaires nationaux de lutte contre la piraterie.

  1. JPCam: Development of a 1.2 Gpixel Camera for the J-PAS Survey

    Science.gov (United States)

    Marín-Franch, A.; Taylor, K.; Santoro, F. G.; Laporte, R.; Cepa, J.; Lasso-Cabrera, N.; Yanes-Díaz, A.; Cenarro, A. J.; Cristobal-Hornillos, D.; Ederoclite, A.; Moles, M.; Varela, J.; Vázquez-Ramió, H.; Antón, J. L.; Bello, R.; Civera, T.; Castillo, J.,; Chueca, S.; Guillén-Civera, L.; Hernández-Fuertes, J.; Igual, R.; Íniguez, C.; López-Alegre, G.; López-Sainz, A.; Nevot, C.; Milla, R.; Muniesa, D.; Pe, A.; Rueda-Teruel, R.; Rueda-Teruel, F.; Sánchez, J.; Benitez, N.; Dupke, R.; Fernández-Soto, A.; Mendes de Oliveira, C.; Sodré, L.

    2017-03-01

    To carry out J-PAS survey, the JST/T250 telescope at the Observatorio Astrofósico de Javalambre (OAJ) is equipped with JPCam, a panoramic camera designed to exploit survey capabilities of the telescope. JPCam is a direct imaging instrument designed to work in a fast convergent beam at the telescope’s Cassegrain focus. It is based on state-of-the-art, high efficiency, low noise 9.2k-by-9.2k, 10μm pixel CCDs specially developed by e2v for JPCam. The instrument is equipped with a 1.2Gpixel mosaic of 14 CCDs providing a useful FoV of 4.7 deg2 (67% focal plane coverage) with a plate scale of 0.2267 arcsec/pix. Moreover, JPCam includes 12 auxiliary detectors for auto-guiding and wave front sensing purposes. JPCam is completed with an innovative set of 59 optical filters specifically designed to perform accurate BAO measurements, main science driver of J-PAS.

  2. Meeting with Jean-Yves Le Meur, author of "Faux Pas"

    CERN Multimedia

    2008-01-01

    A CERN engineer and an accomplished sportsman, Jean-Yves Le Meur (IT Department) has recently published his first book "Faux pas". Meet him and hear about his exceptional life on 23 April 2008 in the Globe. An accident cost him his legs when he was young, and it was sheer force of character and a passion for the mountains that carried Jean-Yves Le Meur, with one artificial leg and crutches to stay upright, to the very summit of the Mont-Blanc. In his book, Jean-Yves, a computer engineer at CERN, recounts with detachment his personal battle to win back his life and make this impossible ascent. "Faux Pas" depicts a series of encounters and people, and recreates the extreme emotions of a man who reconstructed his life and pushed himself beyond his limits. It is a moving personal account, whose message is universal. The question-and-answer session with the author will be preceded by the projection of "4810M, CAHIN-CAHA",...

  3. Soft tissue-anchored transcutaneous port attached to an intestinal tube for long-term gastroduodenal infusion of levodopa/carbidopa in Parkinson disease.

    Science.gov (United States)

    Nyman, Rickard; Lundgren, Dan; Nyholm, Dag

    2009-04-01

    To report experiences with a transcutaneous soft tissue-anchored titanium port (T-port) attached to an intestinal tube for gastroduodenal infusion of levodopa/carbidopa in patients with Parkinson disease, and to describe and analyze complications related to the T-port, gastrostomy technique, and intestinal tube placement. The T-port implantation and gastrostomy were done under local anesthesia in 15 patients (mean age, 64 years; range, 52-74 y). An intestinal tube (10 F) was attached to the T-port for duodenal/jejunal access. Three versions of the T-port have been tested (generations I-III). Our experience with T-ports covers 34.5 patient-years (mean, 2.3 y per patient). Maximum duration of use was 4.9 years. The major complications were perforation of the skin by the straight flange (three of five generation I ports), local infections (12 of 15 patients) resulting from leakage of levodopa/carbidopa (five of 11 generation II ports), problems with T-fasteners, and poor hygiene. Hypergranulation tissue was often seen as a result of local inflammation/infection resulting from levodopa/carbidopa leakage, poor hygiene, and/or an overly mobile T-port. The last version of the T-port (generation III), with more optimized implantation and gastrostomy techniques, seemed to considerably improve the results. The initial experience with the T-port system reveals that it may be a useful alternative to presently used gastrojejunostomy tubes. Several improvements of the T-port and placement technique were made. The T-port offers a potential advantage compared with standard techniques from an aesthetic point of view.

  4. Location of an intermediate hub for port activities

    Science.gov (United States)

    Burciu, Ş.; Ştefănică, C.; Roşca, E.; Dragu, V.; Ruscă, F.

    2015-11-01

    An intermediate hub might increase the accessibility level of ports but also hinterland and so it can be considered more than a facility with a transhipment role. These hubs might lead to the development of other transport services and enhance their role in gathering and covering economic centres within hinterlands and also getting the part of logistic facility for the ports, with effects on port utilization and its connectivity to global economy. A new location for a hub terminal leads to reduced transport distances within hinterland, with decreased transport costs and external effects, so with gains in people's life quality. Because the production and distribution systems are relatively fixed on short and medium term and the location decisions are strategic and on long term, the logistic chains activities location models have to consider the uncertainties regarding the possible future situations. In most models, production costs are considered equal, the location problem reducing itself to a problem that aims to minimize the total transport costs, meaning the transport problem. The main objective of the paper is to locate a hub terminal that links the producers of cereals that are going to be exported by naval transportation with the Romanian fluvial-maritime ports (Galaţi, Brăila). GIS environment can be used to integrate and analyse a great amount of data and has the ability of using functions as location - allocation models necessary both to private and public sector, being able to determine the optimal location for services like factories, warehouses, logistic platforms and other public services.

  5. Chemiomics: network reconstruction and kinetics of port wine aging.

    Science.gov (United States)

    Monforte, Ana Rita; Jacobson, Dan; Silva Ferreira, A C

    2015-03-11

    Network reconstruction (NR) has proven to be useful in the detection and visualization of relationships among the compounds present in a Port wine aging data set. This view of the data provides a considerable amount of information with which to understand the kinetic contexts of the molecules represented by peaks in each chromatogram. The aim of this study was to use NR together with the determination of kinetic parameters to extract more information about the mechanisms involved in Port wine aging. The volatile compounds present in samples of Port wines spanning 128 years in age were measured with the use of GC-MS. After chromatogram alignment, a peak matrix was created, and all peak vectors were compared to one another to determine their Pearson correlations over time. A correlation network was created and filtered on the basis of the resulting correlation values. Some nodes in the network were further studied in experiments on Port wines stored under different conditions of oxygen and temperature in order to determine their kinetic parameters. The resulting network can be divided into three main branches. The first branch is related to compounds that do not directly correlate to age, the second branch contains compounds affected by temperature, and the third branch contains compounds associated with oxygen. Compounds clustered in the same branch of the network have similar expression patterns over time as well as the same kinetic order, thus are likely to be dependent on the same technological parameters. Network construction and visualization provides more information with which to understand the probable kinetic contexts of the molecules represented by peaks in each chromatogram. The approach described here is a powerful tool for the study of mechanisms and kinetics in complex systems and should aid in the understanding and monitoring of wine quality.

  6. Shutdown dose rates at ITER equatorial ports considering radiation cross-talk from torus cryopump lower port

    Energy Technology Data Exchange (ETDEWEB)

    Juárez, Rafael, E-mail: rjuarez@ind.uned.es [Departamento de Ingeniería Energética, ETSII-UNED, Calle Juan del Rosal 12, Madrid 28040 (Spain); Pampin, Raul [F4E, Torres Diagonal Litoral B3, Josep Pla 2, Barcelona 08019 (Spain); Levesy, Bruno [ITER Organization, 13115 Route de Vinon sur Verdon, St Paul Lez Durance (France); Moro, Fabio [ENEA, Via Enrico Fermi 45, Frascati, Rome (Italy); Suarez, Alejandro [ITER Organization, 13115 Route de Vinon sur Verdon, St Paul Lez Durance (France); Sanz, Javier [Departamento de Ingeniería Energética, ETSII-UNED, Calle Juan del Rosal 12, Madrid 28040 (Spain)

    2015-11-15

    Shutdown dose rates for planned maintenance purposes is an active research field in ITER. In this work the radiation (neutron and gamma) cross-talk between ports in the most conservative case foreseen in ITER is investigated: the presence of a torus cryopump lower port, mostly empty for pumping efficiency reasons. There will be six of those ports: #4, #6, #10, #12, #16 and #18. The equatorial ports placed above them will receive a significant amount of additional radiation affecting the shutdown dose rates during in situ maintenance activities inside the cryostat, and particularly in the port interspace area. In this study a general situation to all the equatorial ports placed above torus cryopump lower ports is considered: a generic diagnostics equatorial port placed above the torus cryopump lower port (LP#4). In terms of shutdown dose rates at equatorial port interspace after 10{sup 6} s of cooling time, 405 μSv/h has been obtained, of which 160 μSv/h (40%) are exclusively due to radiation cross-talk from a torus cryopump lower port. Equatorial port activation due to only “local neutrons” contributes 166 μSv/h at port interspace, showing that radiation cross-talk from such a lower port is a phenomenon comparable in magnitude to the neutron leakage though the equatorial port plug.

  7. Evolução das relações entre cidades e portos: entre lógicas homogeneizantes e dinâmicas de diferenciação Évolution des relations entre villes et ports: entre logiques homogénéisatrices et dynamiques de différenciation Evolution of relationships between cities and ports: homogenizing trends and differentiation dynamics

    Directory of Open Access Journals (Sweden)

    Flavia Nico Vasconcelos

    2012-06-01

    maille globale des interactions spatiales de longue distance redéfinit le paysage institutionnel, les modalités technico opérationnelles et l´organisation spatiale du système portuaire mondial. La situation des ports, par lesquels transite l´essentiel du commerce international de marchandises, n´en est pas moins paradoxale et complexe. Les stratégies développées par les acteurs dominant l´horizon maritime du port et celles imposées par les acteurs économiques dominant son horizon terrestre, placent les villes portuaires dans le double champs des réseaux du transport et de la production. L´enjeu pour les politiques portuaires, oscillant entre concurrence et complémentarité, consiste donc à positionner le port au cœur de ces réseaux en incorporant un nombre croissant de variables économiques, commerciales, urbanistiques, environnementales et sociales face aux rationnalités fonctionnelles et territoriales d´acteurs pouvant transformer le port en simple nœud de transbordement ou, à l´opposé, en grand centre logistique. S’appuyant sur la définition des ports de commerce comme territoires multi-situés dont les marges de manœuvre sur «l’échiquier» mondial et régional sont à l´origine d´une articulation différenciée des compétences liées au port de commerce, au système productif et aux ressources du territoire urbain, une analyse de leur trajectoire à trois échelles, au niveau global, dans le cadre de la mondialisation ; au niveau méso-économique, au sein de systèmes régionaux qui capturent des volumes croissants de flux et d´activités de transformation; et au niveau local, sur le territoire de la ville portuaire permet d´élaborer une typologie des villes portuaires comme territoires circulatoires et/ou productifs.The current stage of globalisation presents mutations that act on the global network of long distance spatial interactions and redefine the institutional scenery, the technic-operational modalities and the

  8. Port Graham Community Building Biomass Heating Design Project

    Energy Technology Data Exchange (ETDEWEB)

    Norman, Patrick [Port Graham Village Corporation, Anchorage, AK (United States); Sink, Charles [Chugachmiut, Anchorage, Alaska (United States)

    2015-04-30

    Native Village of Port Graham completed preconstruction activities to prepare for construction and operations of a cord wood biomass heating system to five or more community buildings in Port Graham, Alaska. Project Description Native Village of Port Graham (NVPG) completed preconstruction activities that pave the way towards reduced local energy costs through the construction and operations of a cord wood biomass heating system. NVPG plans include installation of a GARN WHS 3200 Boiler that uses cord wood as fuel source. Implementation of the 700,000 Btu per hour output biomass community building heat utility would heat 5-community buildings in Port Graham, Alaska. Heating system is estimated to displace 85% of the heating fuel oil or 5365 gallons of fuel on an annual basis with an estimated peak output of 600,000 Btu per hour. Estimated savings is $15,112.00 per year. The construction cost estimate made to install the new biomass boiler system is estimated $251,693.47 with an additional Boiler Building expansion cost estimated at $97,828.40. Total installed cost is estimated $349,521.87. The WHS 3200 Boiler would be placed inside a new structure at the old community Water Plant Building site that is controlled by NVPG. Design of the new biomass heat plant and hot water loop system was completed by Richmond Engineering, NVPG contractor for the project. A hot water heat loop system running off the boiler is designed to be placed underground on lands controlled by NVPG and stubbed to feed hot water to existing base board heating system in the following community buildings: 1. Anesia Anahonak Moonin Health and Dental Clinic 2. Native Village of Port Graham offices 3. Port Graham Public Safety Building/Fire Department 4. Port Graham Corporation Office Building which also houses the Port Graham Museum and Head Start Center 5. North Pacific Rim Housing Authority Workshop/Old Fire Hall Existing community buildings fuel oil heating systems are to be retro-fitted to

  9. Application of FTIR-PAS and Raman spectroscopies for the determination of organic matter in farmland soils.

    Science.gov (United States)

    Xing, Zhe; Du, Changwen; Tian, Kang; Ma, Fei; Shen, Yazhen; Zhou, Jianmin

    2016-09-01

    In soil analysis, Raman spectroscopy is not as widely used as infrared spectroscopy mainly owing to fluorescence interferences. This paper investigated the feasibility of Fourier-transform infrared photoacoustic (FTIR-PAS) and Raman spectroscopies for predicting soil organic matter (SOM) using partial least squares regression (PLSR) analysis. 194 farmland soil samples were collected and scanned with FTIR and Raman spectrometers in the spectral range of 4000-400cm(-1) and 180-3200cm(-1), respectively. For the PLSR models, the combined dataset was split into 146 samples as the calibration set (75%) and 48 samples as the validation set (25%). The optimal number of analytical factors was determined using a leave-one-out cross-validation. The results showed that SOM could be predicted using FTIR-PAS and Raman spectroscopies independently, with R(2)>0.70 and RPD>1.8 for the validation sets. In comparison to the single applications of FTIR-PAS and Raman spectroscopies, accurate prediction of SOM was made by combining FTIR-PAS and Raman spectroscopies, with R(2)=0.81 and RPD=2.18 for the validation sets. By statistically assessing large amounts of PLS models, model-population analysis confirmed that the accuracy of the PLS model can be increased by combining FTIR-PAS and Raman spectroscopies. In conclusion, the combination of FTIR-PAS and Raman spectroscopies is a promising alternative for soil characterization, especially for the prediction of SOM, owing to the availability of complementary information from both FTIR-PAS (polar vibrations) and Raman spectroscopy (non-polar vibrations). Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Vacuolated PAS-positive lymphocytes as an hallmark of Pompe disease and other myopathies related to impaired autophagy.

    Science.gov (United States)

    Pascarella, Angelo; Terracciano, Chiara; Farina, Olimpia; Lombardi, Luca; Esposito, Teresa; Napolitano, Filomena; Franzese, Giuseppina; Panella, Giovanni; Tuccillo, Francesco; la Marca, Giancarlo; Bernardini, Sergio; Boffo, Silvia; Giordano, Antonio; Melone, Mariarosa Anna Beatrice; Di Iorio, Giuseppe; Sampaolo, Simone

    2017-12-07

    Autosomal recessive Pompe disease is a lysosomal disorder caused by mutations of the acid-α-glucosidase (GAA) gene. Deficiency of GAA enzyme leads to glycogen accumulation and autophagy impairment in cardiac and skeletal muscles, but also in lymphocytes. Since an effective therapy is available, a rapid, sensitive and specific test is crucial to early identify affected subjects. Number of lymphocytes containing PAS-positive vacuoles was evaluated on blood films from 72 consecutive adult patients with hyperckemia and/or muscle weakness, 13 genetically confirmed late-onset-Pompe-disease (LOPD) and 13 of their offspring. GAA activity, measured on dried blood spot (DBS) in all patients inversely correlated with number of PAS-positive lymphocytes. More than 4 PAS-positive lymphocytes were found in 11 out of the 72 patients (6 new diagnosis of LOPD, 3 different glycogen storage myopathies, 1 glucose-6-phosphate dehydrogenase deficiency, 1 caveolinopathy), in all 13 LOPD patients and in the 13 LOPD offspring. These latter resulted to have all a single GAA mutation but low GAA levels. Immunostaining with the autophagy markers LC3 and p62 confirmed the autophagic nature of lymphocytes vacuoles. ROC curve assessment of PAS-positive lymphocytes disclosed 100% of sensitivity and 94% of specificity in recognizing both compound heterozygous and heterozygous GAA carriers. The other myopathies with more than 4 PAS-positive lymphocytes appeared to be all related to impaired autophagy, which seems to be responsible of PAS-positive vacuolated lymphocytes formation. Quantification of PAS-positive lymphocytes in blood films is useful to identify autophagic vacuolar myopathies and should be routinely used as first level test for Pompe disease. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  11. Specialization and Flexibility in Port Cargo Handling

    Directory of Open Access Journals (Sweden)

    Hakkı KİŞİ

    2016-11-01

    Full Text Available Cargo handling appears to be the fundamental function of ports. In this context, the question of type of equipment and capacity rate need to be tackled with respect to cargo handling principles. The purpose of this study is to discuss the types of equipment to be used in ports, relating the matter to costs and capacity. The question is studied with a basic economic theoretical approach. Various conditions like port location, size, resources, cargo traffic, ships, etc. are given parameters to dictate the type and specification of the cargo handling equipment. Besides, a simple approach in the context of cost capacity relation can be useful in deciding whether to use specialized or flexible equipment. Port equipment is sometimes expected to be flexible to handle various types of cargo as many as possible and sometimes to be specialized to handle one specific type of cargo. The cases that might be suitable for those alternatives are discussed from an economic point of view in this article. Consequently, effectiveness and efficiency criteria play important roles in determining the handling equipment in ports.

  12. Integration of remote sensing (RS) and geographic information system (GIS) techniques for change detection of the land use and land cover (LULC) for soil management in the southern Port Said region, Egypt

    Science.gov (United States)

    Hassan, Mohamed Abd El Rehim Abd El Aziz

    2014-11-01

    The monitoring of land use/land cover (LULC) changes in southern Port Said region area is very important for the planner of managements, governmental and non-governmental organizations, decision makers and the scientific community. This information is essential for planning and implementing policies to optimize the use of natural resources and accommodate development whilst minimizing the impact on the environment. To monitor these changes in the study area, two sets of satellite images (Landsat TM-5 and ETM+7) data were used with Path/Row (175/38) in date 1986 and 2006, respectively. The Landsat TM and ETM data are useful for this type of study due to its high spatial resolution, spectral resolution and low repetitive acquisition (16 days). A postclassification technique is used in this study based on hybrid classification (Unsupervised and Supervised). Each method used was assessed, and checked in field. Eight to Twelve LULC classes are recognized and mapping produced. The soils in southern Port Said area were classification in two orders for soil taxonomic units, which are Entisols and Aridisols and four sub-orders classes. The study land was evaluated into five classes from non suitable (N) to very highly suitable (S1) for some crops in the southern region of Port Said studied soils, with assess the nature of future change following construction of the international coastal road which crosses near to the study area.

  13. Relative Efficiencies of ASEAN Container Ports based on Data Envelopment Analysis

    Directory of Open Access Journals (Sweden)

    Nikola Kutin

    2017-07-01

    Full Text Available Ports play a critical role in the economies of many countries in the ASEAN region. Efficient ports facilitate a country's imports and exports, and the “relative efficiency” of a port is evaluated based on its efficiency compared to others in its group. This study analyzes the relative efficiencies of 50 ASEAN container ports and terminals. These ports are categorized according to their container handling system and location (those located in a riverbank connected to the sea are called “inland seaports” and those by the seaside are called “seaports”. The traditional output-oriented data envelopment analysis method is applied, and measures of super-efficiency constant returns to scale are estimated in order to compare the units situated on the efficiency frontier. The findings may support port managers in the ASEAN region to make decisions on whether to increase container traffic. In addition, policymakers may consider the evaluation results in deciding whether to improve the trans-ASEAN transport network and ASEAN trade competitiveness.

  14. Hardware and software facilities for the J-PAS and J-PLUS surveys archiving, processing and data publication

    Science.gov (United States)

    Cristóbal-Hornillos, D.; Varela, J.; Ederoclite, A.; Vázquez Ramió, H.; López-Sainz, A.; Hernández-Fuertes, J.; Civera, T.; Muniesa, D.; Moles, M.; Cenarro, A. J.; Marín-Franch, A.; Yanes-Díaz, A.

    2015-05-01

    The Observatorio Astrofísico de Javalambre consists of two main telescopes: JST/T250, a 2.5 m telescope with a FoV of 3 deg, and JAST/T80, a 83 cm with a 2 deg FoV. JST/T250 will be devoted to complete the Javalambre-PAU Astronomical Survey (J-PAS). It is a photometric survey with a system of 54 narrow-band plus 3 broad-band filters covering an area of 8500°^2. The JAST/T80 will perform the J-PLUS survey, covering the same area in a system of 12 filters. This contribution presents the software and hardware architecture designed to store and process the data. The processing pipeline runs daily and it is devoted to correct instrumental signature on the science images, to perform astrometric and photometric calibration, and the computation of individual image catalogs. In a second stage, the pipeline performs the combination of the tile mosaics and the computation of final catalogs. The catalogs are ingested in as Scientific database to be provided to the community. The processing software is connected with a management database to store persistent information about the pipeline operations done on each frame. The processing pipeline is executed in a computing cluster under a batch queuing system. Regarding the storage system, it will combine disk and tape technologies. The disk storage system will have capacity to store the data that is accessed by the pipeline. The tape library will store and archive the raw data and earlier data releases with lower access frequency.

  15. Dante n’est pas uniquement sévère (Dante no es únicamente severo ou comment ne pas raconter une histoire

    Directory of Open Access Journals (Sweden)

    Jean-Paul Aubert

    2011-01-01

    Full Text Available Dante no es únicamente severo [Dante n’est pas uniquement sévère], un film de Joaquín Jordà et Jacinto Esteva, s’est voulu une vitrine de l’Ecole de Barcelone. Ce courant cinématographique actif à partir de 1965 et jusqu’au début des années soixante-dix, s’est notamment distingué par son refus de l’orthodoxie du récit. A ce titre, il a pu apparaître comme un avatar des cinémas de la modernité. Mais, l’Ecole de Barcelone et ce film qui en synthétise les principes doivent être envisagés dans le contexte particulier de l’Espagne sous le franquisme. La contestation du récit y acquiert une dimension politique et éthique.Dante no es únicamente severo, una película de Joaquín Jordà y Jacinto Esteva, pretende hacer la síntesis del proyecto estético de la Escuela de Barcelona (una corriente cinematográfica activa desde del año 1965 y hasta principios de la década de los setenta. Por su rechazo de la ortodoxia del relato la Escuela de Barcelona se sitúa en la continuidad de los cines de la modernidad. Sin embargo, conviene examinar esta corriente y este film, en particular, en el contexto particular de la España franquista, donde el rechazo del relato abarca dimensiones política y éticas.

  16. Development Possibilities of the Port of Koper

    Directory of Open Access Journals (Sweden)

    Igor Trupac

    2002-03-01

    Full Text Available The extent to which Slovenia will exploit its good geographictransport position, whether it will be merely a transportcorridor or assume an additional quality (e.g. a distributioncentre or a logistic centre will depend on a cluster of circumstances.The importance will also be laid on how Slovenia willpresent itself and what it will offer to Europe and the rest of theworld. One of its best assets is the Port of Koper (favourable position,good condition, capacities in the frame of the whole logisticsystem.A larger volume of transport and consequently be/fer exploitationof the Port of Koper will in the future depend on increasedtransit. However, to acquire new cargo, the mere installationand modernisation of port infrastructure and rise in thequality of services may not be sufficient: it will also require goodconnections to the hinterland.

  17. The polypeptide biophysics of proline/alanine-rich sequences (PAS): Recombinant biopolymers with PEG-like properties.

    Science.gov (United States)

    Breibeck, Joscha; Skerra, Arne

    2017-10-27

    PAS polypeptides comprise long repetitive sequences of the small L-amino acids proline, alanine and/or serine that were developed to expand the hydrodynamic volume of conjugated pharmaceuticals and prolong their plasma half-life by retarding kidney filtration. Here, we have characterized the polymer properties both of the free polypeptides and in fusion with the biopharmaceutical IL-1Ra. Data from size exclusion chromatography, dynamic light scattering, circular dichroism spectroscopy and quantification of hydrodynamic and polar properties demonstrate that the biosynthetic PAS polypeptides exhibit random coil behavior in aqueous solution astonishingly similar to the chemical polymer poly-ethylene glycol (PEG). The solvent-exposed PAS peptide groups, in the absence of secondary structure, account for strong hydrophilicity, with negligible contribution by the Ser side chains. Notably, PAS polypeptides exceed PEG of comparable molecular mass in hydrophilicity and hydrodynamic volume while exhibiting lower viscosity. Their uniform monodisperse composition as genetically encoded polymers and their biological nature, offering biodegradability, render PAS polypeptides a promising PEG mimetic for biopharmaceutical applications. © 2017 The Authors Biopolymers Published by Wiley Periodicals, Inc.

  18. Container Boom in the Port of Koper

    Directory of Open Access Journals (Sweden)

    Elen Twrdy

    2012-03-01

    Full Text Available For the Port of Koper the Central and Eastern European market is very important. The Port of Koper is especially interesting for goods flows relating to the exchange of goods on the East – West route (and vice versa and bound for the EU, in particular to the catchment area of the North Adriatic ports.The year 2009 was a difficult year for business, especially due to the uncertain international economic situation. In the first nine months of 2010, 16% more goods were handled in the Port of Koper than in the same period in 2009. The container transport especially exploded in tons (45% increase as well as in container units (40% increase. Within this period they handled 355,000 TEUs (new record in the container terminal (214,000 TEUs in the same period on the seventh pier in Trieste.The growth of container transport in the Port of Koper as well as the beginning of construction on the new container terminal have made the reconstruction and extension of the current container terminal an absolute priority. The extension is in line with the estimated growth of traffic as well as with the exploitation of present and future terminal capacities.This paper aims to present and analyse: (I supply chains of the flow of containerised goods through the Port of Koper to/from the countries of Central and Eastern Europe; (II the changes which enable this boom, current state and strategies to handle even more containers in the future; (iii market potential, current and future investments in new capacities.

  19. World port cities as cosmopolitan risk community

    DEFF Research Database (Denmark)

    Blok, Anders; Tschötschel, Robin

    2015-01-01

    Extending Ulrich Beck’s theory of world risk society, this article traces the emergence of a cosmopolitan risk community of world port cities in Europe and East Asia, constituted around shared imaginations of the global risks and opportunities of climate change. Such urban risk imaginations...... indication of this cosmopolitan risk community, in terms of the timing, intensity, priorities and modes of government manifested in the climate policy engagements of 16 major world port cities across the regions of Europe and East Asia. The substantial similarities in such policy engagements, we conclude...

  20. Strategic Planning for Port Development: Improvement of Container Transit from the Iranian Southern Ports Terminals

    Directory of Open Access Journals (Sweden)

    Homayoun Yousefi

    2013-09-01

    Full Text Available The author attempts to highlight the significance of the Iranian southern ports development strategy planning which allows for the maximum container transit with minimum resources such as service capacities, human resources, and financial potential in order to expand the Iranian container transit. It should be noted that the strategic objectives, the business strategy and its implementation can be arranged only after the port vision and mission obviously delineated. For the purpose of improving the outcome of the ports operational management, it is recommended to concentrate on new strategies such as exploit of transit corridors for development of the Iranian South Ports. The main part of this paper is dedicated to evaluate the role of container transit from the Iranian south ports terminals from various transport corridors in order to improve Maritime Transport in Iran. The importance of defin¬ing the existing and potential competitors at the Persian Gulf and making a comparison between their and our own strengths and weaknesses is of utmost importance. Sometimes, the real business opportunities and threats are placed beyond one’s own line of indus¬try and business. It is therefore necessary to make a careful analysis of the port environment. After the port competition and environment have been analyzed, it would be possible to initiate the building of the SWOT analysis for the Iranian Southern Container Terminals such as Khoramshahr, Imam Khomani, Busher, Bandar Abbas and Chabahar port which have suitable strategic position as transit base in the region. The SWOT analysis method is therefore applied aiming at defining the weaknesses and strengths of the economic subjects as well as opportunities and threats coming from the environment. The next segment of this paper is dedicated to consider the role of dry ports and the International North-South Transit Corridor for the purpose of improving the Iranian container trade.