WorldWideScience

Sample records for system mps development

  1. MPS II drift chamber system

    Energy Technology Data Exchange (ETDEWEB)

    Platner, E.D.

    1982-01-01

    The MPS II detectors are narrow drift space chambers designed for high position resolution in a magnetic field and in a very high particle flux environment. Central to this implementation was the development of 3 multi-channel custom IC's and one multi-channel hybrid. The system is deadtimeless and requires no corrections on an anode-to-anode basis. Operational experience and relevance to ISABELLE detectors is discussed.

  2. Mucopolysaccharidosis (MPS) Physical Symptom Score: Development, Reliability, and Validity

    OpenAIRE

    Ahmed, A.; Rudser, K.; Kunin-Batson, A.; Delaney, K; Whitley, C.; Shapiro, E

    2015-01-01

    Objectives: We quantified medical signs and symptoms to construct the Physical Symptom Score (PSS) for use in research to assess somatic disease burden in mucopolysaccharidoses (MPS) to track disease and monitor treatments. We examined scoring reliability, its concurrent validity with other measures, and relationship to age in MPS type I.

  3. 3D simulation of eutectic interaction of Pb–Sn system using Moving Particle Semi-implicit (MPS) method

    International Nuclear Information System (INIS)

    Highlights: • Development of MPS eutectic model for solid–solid interaction. • Analysis of experiments dealing with eutectic behavior of Pb–Sn by MPS simulation. • The analysis has revealed the mechanism of eutectic melting due to eutectic reaction. - Abstract: The eutectic reaction phenomenon was analyzed based on the Moving Particle Semi-implicit (MPS) method. The improved MPS code was applied to three-dimensional Pb–Sn system experiments conducted at Central Research Institute of Electric Power Industry (CRIEPI). The experiments dealt with solid–solid contact materials at 225 and 205 °C. The mass diffusion process was modeled based on Fick’s second law. The criterion of eutectic reaction was modeled based on binary phase diagram. The calculated penetration rates, i.e. height reduction rates, were compared with the experimental measurements. The results obtained by the MPS simulations exhibit good agreement with the experiments carried out at 205 and 225 °C. MPS simulation predicted that Sn particle will liquefy earlier than Pb particle

  4. MPS Editor

    Science.gov (United States)

    Mathews, William S.; Liu, Ning; Francis, Laurie K.; OReilly, Taifun L.; Schrock, Mitchell; Page, Dennis N.; Morris, John R.; Joswig, Joseph C.; Crockett, Thomas M.; Shams, Khawaja S.

    2011-01-01

    Previously, it was time-consuming to hand-edit data and then set up simulation runs to find the effect and impact of the input data on a spacecraft. MPS Editor provides the user the capability to create/edit/update models and sequences, and immediately try them out using what appears to the user as one piece of software. MPS Editor provides an integrated sequencing environment for users. It provides them with software that can be utilized during development as well as actual operations. In addition, it provides them with a single, consistent, user friendly interface. MPS Editor uses the Eclipse Rich Client Platform to provide an environment that can be tailored to specific missions. It provides the capability to create and edit, and includes an Activity Dictionary to build the simulation spacecraft models, build and edit sequences of commands, and model the effects of those commands on the spacecraft. MPS Editor is written in Java using the Eclipse Rich Client Platform. It is currently built with four perspectives: the Activity Dictionary Perspective, the Project Adaptation Perspective, the Sequence Building Perspective, and the Sequence Modeling Perspective. Each perspective performs a given task. If a mission doesn't require that task, the unneeded perspective is not added to that project's delivery. In the Activity Dictionary Perspective, the user builds the project-specific activities, observations, calibrations, etc. Typically, this is used during the development phases of the mission, although it can be used later to make changes and updates to the Project Activity Dictionary. In the Adaptation Perspective, the user creates the spacecraft models such as power, data store, etc. Again, this is typically used during development, but will be used to update or add models of the spacecraft. The Sequence Building Perspective allows the user to create a sequence of activities or commands that go to the spacecraft. It provides a simulation of the activities and

  5. FEDERAL USERS CONFERENCE PRODUCT LINE TOOL SET (PLTS) MAP PRODUCTION SYSTEM (MPS) ATLAS CUSTOM GRIDS [Rev 0 was draft

    International Nuclear Information System (INIS)

    Maps, and more importantly Atlases, are assisting the user community in managing a large land area with complex issues, the most complex of which is the management of nuclear waste. The techniques and experiences discussed herein were gained while developing several atlases for use at the US Department of Energy's Hanford Site. The user community requires the ability to locate not only waste sites, but other features as well. Finding a specific waste site on a map and in the field is a difficult task at a site the size of Hanford. To find a specific waste site, the user begins by locating the item or object in an index, then locating the feature on the corresponding map within an atlas. Locating features requires a method for indexing them. The location index and how to place it on a map or atlas is the central theme presented in this article. The user requirements for atlases forced the design team to develop new and innovative solutions for requirements that Product Line Tool Set (PLTS) Map Production System (MPS)-Atlas was not designed to handle. The layout of the most complex atlases includes custom reference grids, multiple data frames, multiple map series, and up to 250 maps. All of these functional requirements are at the extreme edge of the capabilities of PLTS MPS-Atlas. This document outlines the setup of an atlas using PLTS MPS-Atlas to meet these requirements

  6. Brain Targeting in MPS-IIIA.

    Science.gov (United States)

    Sorrentino, Nicolina Cristina; Fraldi, Alessandro

    2016-06-01

    Mucopolysaccharidosis type IIIA (MPS-IIIA) is a childhood metabolic neuropathology caused by the inherited deficiency of the lysosomal enzyme sulfamidase and is characterized by the accumulation of undegraded glycosaminoglycans in the lysosomes of cells and tissues of affected patients. MPS-IIIA represents one of the most common forms of lysosomal storage disorders (LSDs) and to date there is no cure. Since neurodegeneration is the most relevant pathological feature in MPS-IIIA patients, the treatment of the central nervous system (CNS) lesions represents the goal of any effective therapy for this devastating disorder. During the last years many advances have been made in developing and testing new therapies for brain involvement in MPS-IIIA. These studies have been possible because of the availability of mouse and dog models that recapitulate the MPS-IIIA neuropathological features. Some of these approaches are based on direct CNS administration routes through which the therapeutic molecules access the CNS via the parenchyma (intracerebral injections) or via the cerebrospinal fluid (intraventricular/intrathecal injections). These approaches are highly invasive and poorly suited for clinical use. Minimally invasive approaches are based on systemic injections into the blood stream of therapeutics capable of crossing the blood-brain barrier (BBB). This review will present the background of the clinic and pathology aspects of MPS-IIIA and will describe the current MPS-IIIA preclinical and clinical studies focusing on how a systemic therapeutic strategy based on crossing the BBB has been successfully used to treat CNS pathology and behavioral abnormalities in a mouse model of MPS-IIIA. Future clinical applications of this approach to MPS-IIIA patients will be also discussed together with the possibility of using similar strategies in other LSDs with neurological involvement. PMID:27491210

  7. National MPS Society (Mucopolysaccharidoses)

    Science.gov (United States)

    ... Palliative Care Newborn Screening MPS I Recruitment – MAYO clinic Resources Pharmaceutical Partners BioMarin Genzyme Shire Specialty Pharmacy Providers Orsini Healthcare Compassionate Use Education Library MPS ...

  8. Functional correction of neurological and somatic disorders at later stages of disease in MPS IIIA mice by systemic scAAV9-hSGSH gene delivery.

    Science.gov (United States)

    Fu, Haiyan; Cataldi, Marcela P; Ware, Tierra A; Zaraspe, Kimberly; Meadows, Aaron S; Murrey, Darren A; McCarty, Douglas M

    2016-01-01

    The reversibility of neuropathic lysosomal storage diseases, including MPS IIIA, is a major goal in therapeutic development, due to typically late diagnoses and a large population of untreated patients. We used self-complementary adeno-associated virus (scAAV) serotype 9 vector expressing human N-sulfoglucosamine sulfohydrolase (SGSH) to test the efficacy of treatment at later stages of the disease. We treated MPS IIIA mice at 1, 2, 3, 6, and 9 months of age with an intravenous injection of scAAV9-U1a-hSGSH vector, leading to restoration of SGSH activity and reduction of glycosaminoglycans (GAG) throughout the central nervous system (CNS) and somatic tissues at a dose of 5E12 vg/kg. Treatment up to 3 months age improved learning ability in the Morris water maze at 7.5 months, and lifespan was normalized. In mice treated at 6 months age, behavioral performance was impaired at 7.5 months, but did not decline further when retested at 12 months, and lifespan was increased, but not normalized. Treatment at 9 months did not increase life-span, though the GAG storage pathology in the CNS was improved. The study suggests that there is potential for gene therapy intervention in MPS IIIA at intermediate stages of the disease, and extends the clinical relevance of our systemic scAAV9-hSGSH gene delivery approach. PMID:27331076

  9. Functional correction of neurological and somatic disorders at later stages of disease in MPS IIIA mice by systemic scAAV9-hSGSH gene delivery

    OpenAIRE

    Fu, Haiyan; Cataldi, Marcela P.; Ware, Tierra A.; Zaraspe, Kimberly; Meadows, Aaron S; Murrey, Darren A; McCarty, Douglas M

    2016-01-01

    The reversibility of neuropathic lysosomal storage diseases, including MPS IIIA, is a major goal in therapeutic development, due to typically late diagnoses and a large population of untreated patients. We used self-complementary adeno-associated virus (scAAV) serotype 9 vector expressing human N-sulfoglucosamine sulfohydrolase (SGSH) to test the efficacy of treatment at later stages of the disease. We treated MPS IIIA mice at 1, 2, 3, 6, and 9 months of age with an intravenous injection of s...

  10. MPS/CAS Partner Group on the Development of Mechanical Knowledge in China

    Institute of Scientific and Technical Information of China (English)

    Zhang Baichun; Jürgen Renn

    2004-01-01

    @@ China's long and continuous cultural tradition offers scholars the special opportunity for cross-cultural studies in the long-term development of science. The Partner Group focuses on an exemplary case of such long-term development, the development of mechanical knowledge in China from antiquity to the early modern period.

  11. Replacement of heavy components of the Main Primary System (MPS). Recent innovations made by Framatome ANP

    International Nuclear Information System (INIS)

    condition of the various penetrations (lateral or from above, for instrumentation, unloading, spraying, etc.): - Complete replacement of the component (including dissimilar metal welds, thermal sleeves and even a section of the surge line if necessary); - Bottom replacement; - Replacement of faulty penetrations only. Along with the regular replacement of molded Main Primary System elbows (SGR operations), the following actions have also been carried out: - Replacement of a half crossover leg (SGR-GR4, 2000); - Replacement of a cold leg section (RCLS) with a chemical and volume control system (CVCS) nozzle (SGR-FH1, 2002). In the future we predict work will be carried out on the pressurizer surge line (potentially carried out as part of a pressurizer changeover or as a stand-alone operation). This presentation will focus on the major innovations developed by Framatome ANP, aided by its international customers in order to carry out these primary component replacement operations as well and as quickly as possible. These innovations concern the following domains: - Hoisting and handling; - Metrology and topo-metry; - Machining and welding; - Automated operations in piping; - Operation management. In conclusion one stresses that to increase the lifetime of their nuclear plants, optimize outages and sometimes increase thermal and electrical power it is necessary to optimize the replacement of heavy primary components. To meet the operator needs, suppliers must in turn enhance their capacity and skills in terms of: - Providing near-turnkey services (supplies and work); - Orchestrating these operations (i.e. by performing the duties of an engineering department); - Providing services in a range of fields, from concrete to instrumentation and control, and even performance testing; - Being technically innovative in all of these areas. Since the 1990's, with the assistance of its worldwide customer base, Framatome ANP has been carrying out this approach thanks to its experience as a

  12. viStaMPS: The Application For Viewing And Manipulating StaMPS Results

    Science.gov (United States)

    Sousa, Joaquim; Sousa, Antonio; Magalhaes, Luis; Ruiz, Antonio

    2013-12-01

    viStaMPS (visual StaMPS) is a new visual application developed to enhance the visualization, manipulation and exportation of StaMPS results. The programmed application is developed in Matlab® through the Graphical User Interface (GUI) and no coding is required for running it, which avoids any programming language knowledge for standard uses. This tool integrates fully new features together with various scripts from StaMPS, allowing the generation of the desired plots/maps in a user-friendly interface. It is done by simply clicking some buttons or changing some parameters located in visual panels, instead of input commands in a prompt. Moreover, since it is written in Matlab, it gives the users the opportunity to access the data very easily and make their own modifications. Being a research tool, viStaMPS is continually under development and will count on the dynamism of its users to improve and/or add new features.

  13. Molten uranium eutectic interaction on iron-alloy by MPS method

    Energy Technology Data Exchange (ETDEWEB)

    Mustari, Asril Pramutadi Andi, E-mail: pramutadi@aoni.waseda.jp; Oka, Yoshiaki

    2014-10-15

    Highlights: • Development of MPS development on eutectic model. • Binary phase diagram of Fe–U system development by THERMOCALC with NUCL10 dataset. • Eutectic behavior of TREAT experiment analysis by MPS simulation. - Abstract: Development of moving particle semi-implicit (MPS) method for predicting the eutectic reaction during severe accident, especially at the lower head, in nuclear power plants is important. In this study, solid–liquid system of eutectic interaction was developed. Mass diffusion theory was used for mass transfer between particles. Binary phase diagram was used for developing criteria of transforming into liquid/eutectic particle. THERMOCALC with NUCL10 dataset was utilized to obtain binary phase diagram. Based on the developed MPS model, the TREAT experiments were analyzed. For penetration rates of molten uranium into steel test section, the two-dimensional MPS simulations predicted agreeable values with the experiments for temperature above 1233 and 1187 °C for Armco iron and SS304, respectively. As for SS430, MPS simulation predicted agreeable result at 1244 °C.

  14. Molten uranium eutectic interaction on iron-alloy by MPS method

    International Nuclear Information System (INIS)

    Highlights: • Development of MPS development on eutectic model. • Binary phase diagram of Fe–U system development by THERMOCALC with NUCL10 dataset. • Eutectic behavior of TREAT experiment analysis by MPS simulation. - Abstract: Development of moving particle semi-implicit (MPS) method for predicting the eutectic reaction during severe accident, especially at the lower head, in nuclear power plants is important. In this study, solid–liquid system of eutectic interaction was developed. Mass diffusion theory was used for mass transfer between particles. Binary phase diagram was used for developing criteria of transforming into liquid/eutectic particle. THERMOCALC with NUCL10 dataset was utilized to obtain binary phase diagram. Based on the developed MPS model, the TREAT experiments were analyzed. For penetration rates of molten uranium into steel test section, the two-dimensional MPS simulations predicted agreeable values with the experiments for temperature above 1233 and 1187 °C for Armco iron and SS304, respectively. As for SS430, MPS simulation predicted agreeable result at 1244 °C

  15. An overview of Korean patients with mucopolysaccharidosis and collaboration through the Asia Pacific MPS Network

    Science.gov (United States)

    Cho, Sung Yoon; Sohn, Young Bae; Jin, Dong-Kyu

    2014-01-01

    Summary Mucopolysaccharidosis (MPS) is a constellation of disorders characterized by the accumulation of mucopolysaccharides in tissues and organs. This accumulation results in the deterioration and degeneration of multiple organs. This paper describes the general distribution of types of MPS in patients, their clinical characteristics and genotypes, the development of animal studies and preclinical studies, enzyme replacement therapy in South Korea, and the development of idursulfase beta and clinical trials on idursulfase beta in South Korea. In addition, this paper discusses academic collaboration among specialists in MPS care in the Asia-Pacific region, which includes Japan, Taiwan, Malaysia, and South Korea, through an organization called the Asia-Pacific MPS Network (APMN). The Asia-Pacific MPS Registry, an electronic remote data entry system, has been developed by key doctors in the APMN. Rare diseases require international cooperation and collaboration to elucidate their mechanisms and carry out clinical trials; therefore, an organization such as the APMN is required. Furthermore, international collaboration among Asian countries and countries around the world will be of utmost importance in the future. PMID:25364648

  16. Space Shuttle Program (SSP) Orbiter Main Propulsion System (MPS) Gaseous Hydrogen (GH2) Flow Control Valve (FCV) Poppet Eddy Current (EC) Inspection Probability of Detection (POD) Study. Volume 1

    Science.gov (United States)

    Piascik, Robert S.; Prosser, William H.

    2011-01-01

    The Director of the NASA Engineering and Safety Center (NESC), requested an independent assessment of the anomalous gaseous hydrogen (GH2) flow incident on the Space Shuttle Program (SSP) Orbiter Vehicle (OV)-105 during the Space Transportation System (STS)-126 mission. The main propulsion system (MPS) engine #2 GH2 flow control valve (FCV) LV-57 transition from low towards high flow position without being commanded. Post-flight examination revealed that the FCV LV-57 poppet had experienced a fatigue failure that liberated a section of the poppet flange. The NESC assessment provided a peer review of the computational fluid dynamics (CFD), stress analysis, and impact testing. A probability of detection (POD) study was requested by the SSP Orbiter Project for the eddy current (EC) nondestructive evaluation (NDE) techniques that were developed to inspect the flight FCV poppets. This report contains the findings and recommendations from the NESC assessment.

  17. Space Shuttle Program (SSP) Orbiter Main Propulsion System (MPS) Gaseous Hydrogen (GH2) Flow Control Valve (FCV) Poppet Eddy Current (EC) Inspection Probability of Detection (POD) Study. Volume 2; Appendices

    Science.gov (United States)

    Piascik, Robert S.; Prosser, William H.

    2011-01-01

    The Director of the NASA Engineering and Safety Center (NESC), requested an independent assessment of the anomalous gaseous hydrogen (GH2) flow incident on the Space Shuttle Program (SSP) Orbiter Vehicle (OV)-105 during the Space Transportation System (STS)-126 mission. The main propulsion system (MPS) engine #2 GH2 flow control valve (FCV) LV-57 transition from low towards high flow position without being commanded. Post-flight examination revealed that the FCV LV-57 poppet had experienced a fatigue failure that liberated a section of the poppet flange. The NESC assessment provided a peer review of the computational fluid dynamics (CFD), stress analysis, and impact testing. A probability of detection (POD) study was requested by the SSP Orbiter Project for the eddy current (EC) nondestructive evaluation (NDE) techniques that were developed to inspect the flight FCV poppets. This report contains the Appendices to the main report.

  18. Obstructive Sleep Apnea in MPS

    Directory of Open Access Journals (Sweden)

    Abhijit Ricky Pal MBBChir, MA, MD, FRCS(ORL-HNS

    2015-11-01

    Full Text Available The mucopolysaccharidoses (MPSs are a group of inherited, metabolic disorders characterized by progressive multisystem accumulation of partially degraded glycosaminoglycans. This manifests with multilevel airway obstruction, presenting with obstructive sleep apnea (OSA. We systematically reviewed the literature to determine the severity and prevalence of OSA in MPS based on polysomnography analysis. Fifteen studies with 294 participants met the inclusion criteria for review. The pretreatment prevalence of OSA in MPS was 81% with a mean apnea–hypopnea index (AHI of 10.4. Patients with MPS I are most significantly affected, with 75% suffering with moderate to severe OSA (mean AHI, 16.6. Enzyme replacement therapy (ERT results in an almost significant reduction in OSA in MPS I (P = .06, while adenotonsillar surgery significantly improves AHI (P = .002. Obstructive sleep apnea least affects MPS III. There is a lack of long-term post-ERT and hematopoietic stem cell transplant data relating to OSA outcomes in this population, with further prospective studies required to determine the ongoing response to treatment.

  19. OLiMPS. OpenFlow Link-layer MultiPath Switching

    Energy Technology Data Exchange (ETDEWEB)

    Newman, Harvey B. [California Institute of Technology, Pasadena, CA (United States); Barczyk, Artur [California Institute of Technology, Pasadena, CA (United States); Bredel, Michael [California Institute of Technology, Pasadena, CA (United States)

    2014-11-17

    The OLiMPS project’s goal was the development of an OpenFlow controller application allowing load balancing over multiple switched paths across a complex network topology. The second goal was to integrate the controller with Dynamic Circuit Network systems such as ESnet’s OSCARS. Both goals were achieved successfully, as laid out in this report.

  20. Mps1 kinase regulates tumor cell viability via its novel role in mitochondria.

    Science.gov (United States)

    Zhang, X; Ling, Y; Guo, Y; Bai, Y; Shi, X; Gong, F; Tan, P; Zhang, Y; Wei, C; He, X; Ramirez, A; Liu, X; Cao, C; Zhong, H; Xu, Q; Ma, R Z

    2016-01-01

    Targeting mitotic kinase monopolar spindle 1 (Mps1) for tumor therapy has been investigated for many years. Although it was suggested that Mps1 regulates cell viability through its role in spindle assembly checkpoint (SAC), the underlying mechanism remains less defined. In an endeavor to reveal the role of high levels of mitotic kinase Mps1 in the development of colon cancer, we unexpectedly found the amount of Mps1 required for cell survival far exceeds that of maintaining SAC in aneuploid cell lines. This suggests that other functions of Mps1 besides SAC are also employed to maintain cell viability. Mps1 regulates cell viability independent of its role in cytokinesis as the genetic depletion of Mps1 spanning from metaphase to cytokinesis affects neither cytokinesis nor cell viability. Furthermore, we developed a single-cycle inhibition strategy that allows disruption of Mps1 function only in mitosis. Using this strategy, we found the functions of Mps1 in mitosis are vital for cell viability as short-term treatment of mitotic colon cancer cell lines with Mps1 inhibitors is sufficient to cause cell death. Interestingly, Mps1 inhibitors synergize with microtubule depolymerizing drug in promoting polyploidization but not in tumor cell growth inhibition. Finally, we found that Mps1 can be recruited to mitochondria by binding to voltage-dependent anion channel 1 (VDAC1) via its C-terminal fragment. This interaction is essential for cell viability as Mps1 mutant defective for interaction fails to main cell viability, causing the release of cytochrome c. Meanwhile, deprivation of VDAC1 can make tumor cells refractory to loss of Mps1-induced cell death. Collectively, we conclude that inhibition of the novel mitochondrial function Mps1 is sufficient to kill tumor cells. PMID:27383047

  1. Some modifications of MPS method for incompressible free surface flow

    OpenAIRE

    Sun, Zhe; Djidjeli, K.; Xing, J. T.; Javed, A.

    2014-01-01

    As a Lagrangian mesh-free method, the Moving Particle Semi-implicit (MPS)[1] method is very suitable for simulating violent flows, such as breaking waves on free surface. However, despite its wide range of applicability, the original MPS algorithm suffers from some inherent difficulties in obtaining an accurate fluid pressure in both spatial and time domain. Different modifications to improve the method have been proposed [2-5] in the literature. In this paper, the authors developed a particl...

  2. Microcontroller Programming and Interfacing TI MPS433

    CERN Document Server

    Barrett, Steven

    2011-01-01

    This book provides a thorough introduction to the Texas Instruments MPS430 microcontroller. The MPS430 is a 16-bit reduced instruction set (RISC) processor that features ultra low power consumption and integrated digital and analog hardware. Variants of the MPS430 microcontroller have been in production since 1993. This provides for a host of MPS430 products including evaluation boards, compilers, and documentation. A thorough introduction to the MPS430 line of microcontrollers, programming techniques, and interface concepts are provided along with considerable tutorial information with many i

  3. Health-Related Quality of Life in Patients with MPS II.

    Science.gov (United States)

    Needham, Mary; Packman, Wendy; Quinn, Natasha; Rappoport, Maxwell; Aoki, Christa; Bostrom, Alan; Cordova, Matthew; Macias, Sandra; Morgan, Cynthia; Packman, Seymour

    2015-08-01

    Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a chronic and progressive X-linked lysosomal disease that mainly affects males. The National MPS Society (2013) reports that MPS II affects 1 in 100,000 to 1 in 150,000 males worldwide. Two distinct forms of the disease are based on age of onset and clinical course: attenuated and severe. MPS II affects many organ systems including the nervous, cardiovascular, gastrointestinal and respiratory systems. Clinical manifestations can include progressive hearing loss, mental impairment, and enlarged liver and spleen. This study focuses on the health-related quality of life of individuals (HRQOL) with MPS II as measured by the parent and self-report versions of the Pediatric Quality of Life Inventory (PedsQL™). Both parents of patients with MPS II as well as patients themselves reported lower scores on all domains of the PedsQL™ (physical, emotional, social and school functioning) indicating that children with MPS II have an overall lower HRQOL when compared to a healthy sample. When compared with patients with other chronic illnesses (cancer, MSUD, galactosemia,), the MPS II sample had significantly lower scores on a number of PedsQL™ scales, suggesting an overall lower HRQOL. No significant relationships were found using scores from parent or self report PedsQL™ measures and length of time on ERT. PMID:25395377

  4. Efficient MPS algorithm for periodic boundary conditions and applications

    OpenAIRE

    Weyrauch, Michael; Rakov, Mykhailo V.

    2013-01-01

    We present an implementation of an efficient algorithm for the calculation of the spectrum of one-dimensional quantum systems with periodic boundary conditions. This algorithm is based on a matrix product representation for quantum states (MPS), and a similar representation for Hamiltonians and other operators (MPO). It is significantly more efficient for systems of about 100 sites and more than for small quantum systems. We apply the formalism to calculate the ground state and first excited ...

  5. MPS Vax monitor and control software architecture

    Energy Technology Data Exchange (ETDEWEB)

    Allison, S.; Spencer, N.; Underwood, K.; VanOlst, D.; Zelanzy, M.

    1993-04-01

    The new Machine Protection System (MPS) now being tested at the SLAC Linear Collider (SLC) includes monitoring and controlling facilities integrated into the existing VAX control system. The actual machine protection is performed by VME micros which control the beam repetition rate on a pulse-by-pulse basis based on measurements from fault detectors. The VAX is used to control and configure the VME micros, configure custom CAMAC modules providing the fault detector inputs, monitor and report faults and system errors, update the SLC database, and interface with the user. The design goals of the VAX software include a database-driven system to allow configuration changes without code changes, use of a standard TCP/IP-based message service for communication, use of existing SLCNET micros for CAMAC configuration, security and verification features to prevent unauthorized access, error and alarm logging and display updates as quickly as possible, and use of touch panels and X-windows displays for the user interface.

  6. Simulation of isothermal multi-phase fuel-coolant interaction using MPS method with GPU acceleration

    Energy Technology Data Exchange (ETDEWEB)

    Gou, W.; Zhang, S.; Zheng, Y. [Zhejiang Univ., Hangzhou (China). Center for Engineering and Scientific Computation

    2016-07-15

    The energetic fuel-coolant interaction (FCI) has been one of the primary safety concerns in nuclear power plants. Graphical processing unit (GPU) implementation of the moving particle semi-implicit (MPS) method is presented and used to simulate the fuel coolant interaction problem. The governing equations are discretized with the particle interaction model of MPS. Detailed implementation on single-GPU is introduced. The three-dimensional broken dam is simulated to verify the developed GPU acceleration MPS method. The proposed GPU acceleration algorithm and developed code are then used to simulate the FCI problem. As a summary of results, the developed GPU-MPS method showed a good agreement with the experimental observation and theoretical prediction.

  7. MPS/CAS Partner Groups in China

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ MPS/CAS Partner Groups have become an important backbone of Sino-German collaboration, and they are considered to function as a nucleus for defining topics for the envisaged next generation of cooperation - as seen from the following reports and future plans.

  8. Analysis of material handling equipment for Maritime Prepositioning Ships (MPS) instream offload

    OpenAIRE

    Sumner, John D.; Kang, Keebom

    1992-01-01

    The Maritime Prepositioning Force (MPF) program enables the United States Marine Corps to globally project rapid and sustainable combat power. The instream method of offloading equipment and supplies from the Maritime Prepositioning Ships (MPS) provides the flexibility needed to respond to a broader range of contingencies dictated by the increasingly dynamic geostrategic environment. In this paper, we develop a simulation model of an MPS instream offloading operation to provide Marine Corps c...

  9. 基于KingView的MPS组态监控系统设计%Design of MPS configuration monitoring system based on KingView

    Institute of Scientific and Technical Information of China (English)

    陈天炎

    2012-01-01

    Based on the modular production system of German company FESTO,this paper designs an online real-time monitoring system for automated production line by KingView soft.System uses Siemens S7-300 series PLC as the main control device,designs the automatic control system hardware and software,implements communication between the PLC and PC,completes the development of the monitoring program and the system real-time online monitoring based on industrial configuration software KingView.%以德国FESTO公司的MPS模块化生产加工系统为基础,设计了一种基于Kingview组态王的自动化生产线实时在线监控系统.系统采用西门子S7-300系列PLC作为主要控制设备,完成自动控制系统的硬件和软件设计,实现PLC与上位机之间的通信,并利用工业组态软件KingView完成监控程序的开发,实现对该系统的实时在线监控.

  10. Development of a fluorescence-based in vivo phagocytosis assay to measure mononuclear phagocyte system function in the rat.

    Science.gov (United States)

    Tartaro, Karrie; VanVolkenburg, Maria; Wilkie, Dean; Coskran, Timothy M; Kreeger, John M; Kawabata, Thomas T; Casinghino, Sandra

    2015-01-01

    The mononuclear phagocyte system (MPS) which provides protection against infection is made up of phagocytic cells that engulf and digest bacteria or other foreign substances. Suppression of the MPS may lead to decreased clearance of pathogenic microbes. Drug delivery systems and immunomodulatory therapeutics that target phagocytes have a potential to inhibit MPS function. Available methods to measure inhibition of MPS function use uptake of radioactively-labeled cells or labor-intensive semi-quantitative histologic techniques. The objective of this work was to develop a non-radioactive quantitative method to measure MPS function in vivo by administering heat-killed E. coli conjugated to a pH-sensitive fluorescent dye (Bioparticles(®)). Fluorescence of the Bioparticles(®) is increased at low pH when they are in phagocytic lysosomes. The amount of Bioparticles(®) phagocytosed by MPS organs in rats was determined by measuring fluorescence intensity in livers and spleens ex vivo using an IVIS(®) Spectrum Pre-clinical In Vivo Imaging System. Phagocytosis of the particles by peripheral blood neutrophils was measured by flow cytometry. To assess method sensitivity, compounds likely to suppress the MPS [clodronate-containing liposomes, carboxylate-modified latex particles, maleic vinyl ether (MVE) polymer] were administered to rats prior to injection of the Bioparticles(®). The E. coli particles consistently co-localized with macrophage markers in the liver but not in the spleen. All of the compounds tested decreased phagocytosis in the liver, but had no consistent effects on phagocytic activity in the spleen. In addition, administration of clodronate liposomes and MVE polymer increased the percentage of peripheral blood neutrophils that phagocytosed the Bioparticles(®). In conclusion, an in vivo rat model was developed that measures phagocytosis of E. coli particles in the liver and may be used to assess the impact of test compounds on MPS function. Still, the

  11. SOD1 nanozyme with reduced toxicity and MPS accumulation.

    Science.gov (United States)

    Jiang, Yuhang; Arounleut, Phonepasong; Rheiner, Steven; Bae, Younsoo; Kabanov, Alexander V; Milligan, Carol; Manickam, Devika S

    2016-06-10

    We previously developed a "cage"-like nano-formulation (nanozyme) for copper/Zinc superoxide dismutase (SOD1) by polyion condensation with a conventional block copolymer poly(ethylene glycol)-b-poly(L-lysine) (PEG-PLL) followed by chemical cross-linking. Herein we report a new SOD1 nanozyme based on PEG-b-poly(aspartate diethyltriamine) (PEG-PAsp(DET), or PEG-DET for short) engineered for chronic dosing. This new nanozyme was spherical (Rg/Rh=0.785), and hollow (60% water composition) nanoparticles with colloidal properties similar to PLL-based nanozyme. It was better tolerated by brain microvessel endothelial/neuronal cells, and accumulated less in the liver and spleen. This formulation reduced the infarct volumes by more than 50% in a mouse model of ischemic stroke. However, it was not effective at preventing neuromuscular junction denervation in a mutant SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS). To our knowledge, this work is the first report of using PEG-DET for protein delivery and a direct comparison between two cationic block copolymers demonstrating the effect of polymer structure in modulating the mononuclear phagocyte system (MPS) accumulation of polyion complexes. PMID:26928528

  12. AAV Gene Therapy for MPS1-associated Corneal Blindness

    OpenAIRE

    Melisa Vance; Telmo Llanga; Will Bennett; Kenton Woodard; Giridhar Murlidharan; Neil Chungfat; Aravind Asokan; Brian Gilger; Joanne Kurtzberg; Jude Samulski, R.; Hirsch, Matthew L.

    2016-01-01

    Although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness. As corneal transplants are met with high rejection rates in MPS1 children, there remains no treatment to prevent blindness or restore vision in MPS1 children. Since MPS1 is caused by mutations in idua, which encodes alpha-L-iduronidase, a gene addition strategy to prevent, and potentially reverse...

  13. Prospects of CAS/MPS Cooperation

    Institute of Scientific and Technical Information of China (English)

    Mu Rongping

    2004-01-01

    @@ In the next 20 years, collaboration between the Chinese Academy of Sciences (CAS) and the Max Planck Society for the Advancement of Science (MPS) will meet with great strategic opportunities. We should seek the chance to innovatively improve our cooperation. This could include further improvement of the mechanisms,expansion of areas, actively seeking new patterns, and strengthening our research on science and technology foresight.

  14. Reservoir Modeling by Data Integration via Intermediate Spaces and Artificial Intelligence Tools in MPS Simulation Frameworks

    International Nuclear Information System (INIS)

    Conditioning stochastic simulations are very important in many geostatistical applications that call for the introduction of nonlinear and multiple-point data in reservoir modeling. Here, a new methodology is proposed for the incorporation of different data types into multiple-point statistics (MPS) simulation frameworks. Unlike the previous techniques that call for an approximate forward model (filter) for integration of secondary data into geologically constructed models, the proposed approach develops an intermediate space where all the primary and secondary data are easily mapped onto. Definition of the intermediate space, as may be achieved via application of artificial intelligence tools like neural networks and fuzzy inference systems, eliminates the need for using filters as in previous techniques. The applicability of the proposed approach in conditioning MPS simulations to static and geologic data is verified by modeling a real example of discrete fracture networks using conventional well-log data. The training patterns are well reproduced in the realizations, while the model is also consistent with the map of secondary data

  15. On the Kinematic Motion Primitives (kMPs - Theory and Application

    Directory of Open Access Journals (Sweden)

    Federico Lorenzo Moro

    2012-10-01

    Full Text Available Human neuromotor capabilities guarantee a wide variety of motions. A full understanding of human motion can be beneficial for rehabilitation or performance enhancement purposes, or for its reproduction on artificial systems like robots. This work aims at describing the complexity of human motion in a reduced dimensionality, by means of kinematic Motion Primitives (kMPs. A set of five invariant kMPs are identified for periodic motions, and a set of two kMPs for discrete motions. It is shown how these two sets of kMPs can be combined to synthesize more complex motion as the simultaneous execution of the periodic and the discrete motions. The results reported are an evidence of the theory of Central Pattern Generators (CPG, showing its effects on the kinematics, and are related to what presented in the literature on the Motor Primitives extracted from EMG signals.Experimental tests with the COmpliant huMANoid (COMAN were performed to show that the kMPs extracted from human subjects can be used to transfer the features of human locomotion to the gait of a robot.

  16. The multiple roles of mps1 in Drosophila female meiosis.

    Directory of Open Access Journals (Sweden)

    William D Gilliland

    2007-07-01

    Full Text Available The Drosophila gene ald encodes the fly ortholog of mps1, a conserved kinetochore-associated protein kinase required for the meiotic and mitotic spindle assembly checkpoints. Using live imaging, we demonstrate that oocytes lacking Ald/Mps1 (hereafter referred to as Ald protein enter anaphase I immediately upon completing spindle formation, in a fashion that does not allow sufficient time for nonexchange homologs to complete their normal partitioning to opposite half spindles. This observation can explain the heightened sensitivity of nonexchange chromosomes to the meiotic effects of hypomorphic ald alleles. In one of the first studies of the female meiotic kinetochore, we show that Ald localizes to the outer edge of meiotic kinetochores after germinal vesicle breakdown, where it is often observed to be extended well away from the chromosomes. Ald also localizes to numerous filaments throughout the oocyte. These filaments, which are not observed in mitotic cells, also contain the outer kinetochore protein kinase Polo, but not the inner kinetochore proteins Incenp or Aurora-B. These filaments polymerize during early germinal vesicle breakdown, perhaps as a means of storing excess outer kinetochore kinases during early embryonic development.

  17. The viStaMPS tool for visualization and manipulation of time series interferometric results

    Science.gov (United States)

    Sousa, Joaquim J.; Magalhães, Luis G.; Ruiz, Antonio M.; Sousa, António M. R.; Cardoso, Gil

    2013-03-01

    In the last decade, Synthetic Aperture Radar Interferometry (InSAR) has become operational as a technique that allows remote detection of deformation at the Earth's surface. Analysis of time series of SAR images extends the area where InSAR can be successfully applied and also permits detection of smaller displacements through the reduction of error sources. Stanford Method for Persistent Scatterers (StaMPS) InSAR implementation, which is based on the processing of multi-temporal SAR data, is widely used for ground deformation monitoring. This is due mainly to its proven reliability and freeware distribution among the scientific community. However, some issues can make the interpretation of the results a difficult task: StaMPS supports data processing based on command prompt, which increases the difficulty of usage by users not familiar with the specific programming language that supports StaMPS. Moreover, several visualization tasks are not implemented in the standard approach requiring that each user develop its own code for visualization and interpretation purposes. In this paper, we present viStaMPS, a new visual application developed to enhance the visualization, manipulation and exportation of StaMPS results. The programmed application is developed in Matlab through the Graphical User Interface (GUI) and no coding is required for running it, which avoids any programming language knowledge for standard uses. The included graphical interface is very versatile allowing the user to choose among several features: visualization, manipulation and exportation of data which are not available in the original StaMPS.

  18. AAV Gene Therapy for MPS1-associated Corneal Blindness.

    Science.gov (United States)

    Vance, Melisa; Llanga, Telmo; Bennett, Will; Woodard, Kenton; Murlidharan, Giridhar; Chungfat, Neil; Asokan, Aravind; Gilger, Brian; Kurtzberg, Joanne; Samulski, R Jude; Hirsch, Matthew L

    2016-01-01

    Although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness. As corneal transplants are met with high rejection rates in MPS1 children, there remains no treatment to prevent blindness or restore vision in MPS1 children. Since MPS1 is caused by mutations in idua, which encodes alpha-L-iduronidase, a gene addition strategy to prevent, and potentially reverse, MPS1-associated corneal blindness was investigated. Initially, a codon optimized idua cDNA expression cassette (opt-IDUA) was validated for IDUA production and function following adeno-associated virus (AAV) vector transduction of MPS1 patient fibroblasts. Then, an AAV serotype evaluation in human cornea explants identified an AAV8 and 9 chimeric capsid (8G9) as most efficient for transduction. AAV8G9-opt-IDUA administered to human corneas via intrastromal injection demonstrated widespread transduction, which included cells that naturally produce IDUA, and resulted in a >10-fold supraphysiological increase in IDUA activity. No significant apoptosis related to AAV vectors or IDUA was observed under any conditions in both human corneas and MPS1 patient fibroblasts. The collective preclinical data demonstrate safe and efficient IDUA delivery to human corneas, which may prevent and potentially reverse MPS1-associated cornea blindness. PMID:26899286

  19. AAV Gene Therapy for MPS1-associated Corneal Blindness

    Science.gov (United States)

    Vance, Melisa; Llanga, Telmo; Bennett, Will; Woodard, Kenton; Murlidharan, Giridhar; Chungfat, Neil; Asokan, Aravind; Gilger, Brian; Kurtzberg, Joanne; Samulski, R. Jude; Hirsch, Matthew L.

    2016-01-01

    Although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness. As corneal transplants are met with high rejection rates in MPS1 children, there remains no treatment to prevent blindness or restore vision in MPS1 children. Since MPS1 is caused by mutations in idua, which encodes alpha-L-iduronidase, a gene addition strategy to prevent, and potentially reverse, MPS1-associated corneal blindness was investigated. Initially, a codon optimized idua cDNA expression cassette (opt-IDUA) was validated for IDUA production and function following adeno-associated virus (AAV) vector transduction of MPS1 patient fibroblasts. Then, an AAV serotype evaluation in human cornea explants identified an AAV8 and 9 chimeric capsid (8G9) as most efficient for transduction. AAV8G9-opt-IDUA administered to human corneas via intrastromal injection demonstrated widespread transduction, which included cells that naturally produce IDUA, and resulted in a >10-fold supraphysiological increase in IDUA activity. No significant apoptosis related to AAV vectors or IDUA was observed under any conditions in both human corneas and MPS1 patient fibroblasts. The collective preclinical data demonstrate safe and efficient IDUA delivery to human corneas, which may prevent and potentially reverse MPS1-associated cornea blindness. PMID:26899286

  20. Numerical simulation of MCCI experiments by MPS method. Validation against SURC-2 and SURC-4 experiments

    International Nuclear Information System (INIS)

    The molten corium-concrete interaction (MCCI) phenomenon was analyzed based on the Moving Particle Semi-implicit (MPS) method. The developed code was applied to one-dimensional SURC-2 and SURC-4 experiments, in which a mixture composed of UO2-ZrO2-Zr and Steel-Zr were used as the melt materials respectively. The phase transition of the melt and the concrete was modeled based on a phase transition model for mixture. The effect of Zr oxidation on the concrete ablation was taken into consideration by introducing the reaction heat of Zr/SiO2 obtained from the condensed phase chemical equations into the melt pool. The calculated concrete ablation rate was compared with the experimental measures and the simulation results of the CORCON code. The simulation results by MPS agreed well with the experimental measures. The experimental and MPS results both indicated that for both experiments Zr oxidation could significantly increase the ablation rate. On the other hand, crust formation and remelting was observed to occur on the interface between the melt and the concrete in the MPS simulation. During the period before crust remelted, the concrete ablation rate calculated by MPS decreased significantly. It was indicated by the MPS results that the crust formation could play an important part in MCCI since it could slow down the concrete ablation rate by preventing the melt from interacting with the concrete. Although the experiments did not clarify this observation, the proof for this phenomenon could be deduced from the decreased concrete ablation rate during the same period of interaction presented by the experimental results. (author)

  1. Initial experience with myocardial perfusion scintigraphy (MPS) in patients awaiting lung volume reduction surgery (LVRS)

    International Nuclear Information System (INIS)

    Full text: LVRS is an effective therapeutic option for patients with end-stage chronic airway limitation (CAL). Pre-operative cardiac assessment in such patients is vital for a favourable outcome. We reviewed the role of MPS in the pre-operative cardiac risk stratification of patients undergoing LVRS. Of 37 patients who underwent LVRS, 25 patients (11M/14F; mean age 59.9 yrs) were evaluated pre-operatively with a MPS. Two had a history of ischaemic heart disease. 17 patients were given dipyridamole (IV - 0.05mg/kg), and eight patients were given dobutamine (IV). The LVEF was determined in 11/25 patients (range - 54-79%, mean 65.5%). Reversible defects were reported in two patients; one involving the antero-lateral wall, confirmed with coronary catheterisation (C/C) (100% LAD lesion) and treated successfully with angioplasty, and 1 involving the inferior wall (false positive on C/C). Two fixed defects were reported, each involving the inferior wall and consistent with a history of prior inferior wall myocardial infarction. The post-operative course was favourable in all patients who had a MPS, except in one who died from sepsis, while another developed mild biventricular failure three months post-operatively. Both these patients had a normal MPS. In those who did not have a MPS study, 2/12 patients died in the post-operative period; one from sepsis (normal C/C), and the other from biventricular failure. No other cardiac complications were documented. Although the population size was small, MPS assisted in the pre-operative cardiac risk stratification and management of patients undergoing LVRS. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

  2. Characterization of novel MPS1 inhibitors with preclinical anticancer activity.

    Science.gov (United States)

    Jemaà, M; Galluzzi, L; Kepp, O; Senovilla, L; Brands, M; Boemer, U; Koppitz, M; Lienau, P; Prechtl, S; Schulze, V; Siemeister, G; Wengner, A M; Mumberg, D; Ziegelbauer, K; Abrieu, A; Castedo, M; Vitale, I; Kroemer, G

    2013-11-01

    Monopolar spindle 1 (MPS1), a mitotic kinase that is overexpressed in several human cancers, contributes to the alignment of chromosomes to the metaphase plate as well as to the execution of the spindle assembly checkpoint (SAC). Here, we report the identification and functional characterization of three novel inhibitors of MPS1 of two independent structural classes, N-(4-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)-2-phenylacetamide (Mps-BAY1) (a triazolopyridine), N-cyclopropyl-4-{8-[(2-methylpropyl)amino]-6-(quinolin-5-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide (Mps-BAY2a) and N-cyclopropyl-4-{8-(isobutylamino)imidazo[1,2-a]pyrazin-3-yl}benzamide (Mps-BAY2b) (two imidazopyrazines). By selectively inactivating MPS1, these small inhibitors can arrest the proliferation of cancer cells, causing their polyploidization and/or their demise. Cancer cells treated with Mps-BAY1 or Mps-BAY2a manifested multiple signs of mitotic perturbation including inefficient chromosomal congression during metaphase, unscheduled SAC inactivation and severe anaphase defects. Videomicroscopic cell fate profiling of histone 2B-green fluorescent protein-expressing cells revealed the capacity of MPS1 inhibitors to subvert the correct timing of mitosis as they induce a premature anaphase entry in the context of misaligned metaphase plates. Hence, in the presence of MPS1 inhibitors, cells either divided in a bipolar (but often asymmetric) manner or entered one or more rounds of abortive mitoses, generating gross aneuploidy and polyploidy, respectively. In both cases, cells ultimately succumbed to the mitotic catastrophe-induced activation of the mitochondrial pathway of apoptosis. Of note, low doses of MPS1 inhibitors and paclitaxel (a microtubular poison) synergized at increasing the frequency of chromosome misalignments and missegregations in the context of SAC inactivation. This resulted in massive polyploidization followed by the activation of mitotic catastrophe. A

  3. Development of fast beam-stop system using RF chopper

    International Nuclear Information System (INIS)

    To avoid heat damage and radioactivation by beam loss of the J-PARC accelerator, Machine Protection System (MPS) has been developed. Actually, high responsibility and high reliability have been achieved in J-PARC. Beam-stop method in addition to a way of RFQ OFF has been requested in order to avoid damage to the RFQ. Therefore, we have been developing a fast beam-stop system by using a RF chopper. The fast beam-stop system, including beam test, is described in this paper. (author)

  4. MPS1 kinase as a potential therapeutic target in medulloblastoma

    Science.gov (United States)

    Alimova, Irina; Ng, June; Harris, Peter; Birks, Diane; Donson, Andrew; Taylor, Michael D.; Foreman, Nicholas K.; Venkataraman, Sujatha; Vibhakar, Rajeev

    2016-01-01

    Medulloblastoma is the most common type of malignant brain tumor that affects children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients perform poorly with significant morbidity. Gene expression profiling has revealed that monopolar spindle 1 (MPS1) (TTK1) is highly expressed in medulloblastoma patient samples compared to that noted in normal cerebellum. MPS1 is a key regulator of the spindle assembly checkpoint (SAC), a mitotic mechanism specifically required for proper chromosomal alignment and segregation. The SAC can be activated in aneuploid cancer cells and MPS1 is overexpressed in many types of cancers. A previous study has demonstrated the effectiveness of inhibiting MPS1 with small-molecule inhibitors, but the role of MPS1 in medulloblastoma is unknown. In the present study, we demonstrated that MPS1 inhibition by shRNA or with a small-molecule drug, NMS-P715, resulted in decreased cell growth, inhibition of clonogenic potential and induction of apoptosis in cells belonging to both the Shh and group 3 medulloblastoma genomic signature. These findings highlight MPS1 as a rational therapeutic target for medulloblastoma. PMID:27633003

  5. Mps1 (Monopolar Spindle 1) Protein Inhibition Affects Cellular Growth and Pro-Embryogenic Masses Morphology in Embryogenic Cultures of Araucaria angustifolia (Araucariaceae)

    Science.gov (United States)

    Douétts-Peres, Jackellinne C.; Cruz, Marco Antônio L.; Reis, Ricardo S.; Heringer, Angelo S.; de Oliveira, Eduardo A. G.; Elbl, Paula M.; Floh, Eny I. S.; Silveira, Vanildo

    2016-01-01

    Somatic embryogenesis has been shown to be an efficient tool for studying processes based on cell growth and development. The fine regulation of the cell cycle is essential for proper embryo formation during the process of somatic embryogenesis. The aims of the present work were to identify and perform a structural and functional characterization of Mps1 and to analyze the effects of the inhibition of this protein on cellular growth and pro-embryogenic mass (PEM) morphology in embryogenic cultures of A. angustifolia. A single-copy Mps1 gene named AaMps1 was retrieved from the A. angustifolia transcriptome database, and through a mass spectrometry approach, AaMps1 was identified and quantified in embryogenic cultures. The Mps1 inhibitor SP600125 (10 μM) inhibited cellular growth and changed PEMs, and these effects were accompanied by a reduction in AaMps1 protein levels in embryogenic cultures. Our work has identified the Mps1 protein in a gymnosperm species for the first time, and we have shown that inhibiting Mps1 affects cellular growth and PEM differentiation during A. angustifolia somatic embryogenesis. These data will be useful for better understanding cell cycle control during somatic embryogenesis in plants. PMID:27064899

  6. Future opportunities for hadron spectroscopy at the MPS

    Energy Technology Data Exchange (ETDEWEB)

    Longacre, R.S.

    1988-12-07

    Before I go into detailed MPS experiments, I will give a summary of the status of lattice gauge calculations of glueball masses plus glueball and hybrid masses from the bag model, and the flux tube model. For the following discussion, I am going to assume that multi-quark states or molecules are best described in terms of the MIT bag model of Jaffe with its spectrum best defined by work done by R.L. Jaffe and F.E. Low using a method called The P-Matrix. Using this method one sees that all 4-quark states will appear as very broad continuum like effects that one would not associate with meson resonances, except for the S* and the delta which forms a very special threshold K/bar K/ bound systems. There is a possibility that the E(1420) may also be related to the J/sup PC/ = 1/sup + +/, qq/bar q//bar q/ spectrum having its width narrowed by a final state interaction.

  7. Nano-WO3 film modified macro-porous silicon (MPS) gas sensor

    Institute of Scientific and Technical Information of China (English)

    Sun Peng; Hu Ming; Li Mingda; Ma Shuangyun

    2012-01-01

    We prepared macro-porous silicon (MPS) by electrochemical corrosion in a double-tank cell on the surface of single-crystalline P-type silicon.Then,nano-WO3 films were deposited on MPS layers by DC facing target reactive magnetron sputtering.The morphologies of the MPS and WOs/MPS samples were investigated by using a field emission scanning electron microscope.The crystallization of WO3 and the valence of the W in the WO3/MPS sample were characterized by X-ray diffraction and X-ray photoelectron spectroscopy,respectively.The gas sensing properties of MPS and WO3/MPS gas sensors were thoroughly measured at room temperature.It can be concluded that:the WO3/MPS gas sensor shows the gas sensing properties of a P-type semiconductor gas sensor.The WO3/MPS gas sensor exhibits good recovery characteristics and repeatability to l ppm NO2.The addition of WO3 can enhance the sensitivity of MPS to NO2.The long-term stability ofa WO3/MPS gas sensor is better than that of an MPS gas sensor.The sensitivity of the WO3/MPS gas sensor to NO2 is higher than that to NH3 and C2H5OH.The selectivity of the MPS to NO2 is modified by deposited nano-WO3 film.

  8. MPS/CAS Partner Group on Nanostructured Materials

    Institute of Scientific and Technical Information of China (English)

    Lu Ke; Manfred Rühle

    2004-01-01

    @@ As one of the first Partner Groups which were initiated to foster scientific exchange and interaction between the Max Pianck Society (MPS) and the Chinese Academy of Sciences (CAS), the Partner Group led by Lu Ke was established on April 1, 1999.During the past five years, the group has received substantial support from the CAS for equipment and from the MPS for personnel and travel expenses. Extensive and productive collaborations between the research staff and students of the Partner Group with several professors (departments) in the Max Planck Institute for Metals Research (MPI-MF) have led to significant advances in synthesis,mechanical properties, melting and superheating of nanostructured metals. The research is well recognized internationally and a substantial number of publications in high quality, peer-reviewed journals (including Science and Physical Review Letters) have resulted.

  9. Comparative studies on exenatide-loaded poly (D,L-lactic-co-glycolic acid) microparticles prepared by a novel ultra-fine particle processing system and spray drying.

    Science.gov (United States)

    Zhu, Chune; Huang, Ying; Zhang, Xiaoying; Mei, Liling; Pan, Xin; Li, Ge; Wu, Chuanbin

    2015-08-01

    The purpose of this study was to compare the properties of exenatide-loaded poly (D,L-lactic-co-glycolic acid) microparticles (Ex-PLGA-MPs) prepared by a novel ultra-fine particle processing system (UPPS) and spray drying. UPPS is a proprietary technology developed by our group based on the disk rotation principle. Characteristics of the MPs including morphology, particle size distribution, drug content, encapsulation efficiency and in vitro release were comparatively studied. Cytotoxicity of the MPs was examined on A549 cells and the pharmacodynamics was investigated in vivo in type 2 diabetes Sprague-Dawley (SD) rats. Ex-PLGA-MPs prepared by UPPS showed larger particle size, denser surface, greater encapsulation efficiency, less initial burst release, and stable sustained release for more than one month in vitro as compared with the spray drying MPs. Meanwhile, the UPPS MPs effectively controlled the body growth rate and blood glucose in diabetes rats for at least three weeks after a single injection, while the spray drying MPs showed effective control period of about two weeks. UPPS technology was demonstrated to manufacture Ex-PLGA-MPs as a potential sustained release protein/polypeptide delivery system, which is an alternative method for the most commonly used spray drying. This comparative research provides a new guidance for microparticle preparation technology. PMID:26037698

  10. MRI morphometric characterisation of the paediatric cervical spine and spinal cord in children with MPS IVA (Morquio-Brailsford syndrome).

    Science.gov (United States)

    Solanki, Guirish A; Lo, William B; Hendriksz, Christian J

    2013-03-01

    Nearly all children with MPS IVA develop skeletal deformities affecting the spine. At the atlanto-axial spine, odontoid hypoplasia occurs. GAG deposition around the dens, leads to peri-odontoid infiltration. Transverse/alar ligament incompetence causes instability. Atlanto-axial instability is associated with cord compression and myelopathy, leading to major morbidity and mortality. Intervention is often required. Does the presence of widened bullet shaped vertebra in platyspondily encroach on the spinal canal and cause spinal stenosis in MPS IVA? So far, there have been no standardised morphometric measurements of the paediatric MPS IVA cervical spine to evaluate whether there is pre-existing spinal stenosis predisposing to compressive myelopathy or whether this is purely an acquired process secondary to instability and compression. This study provides the first radiological quantitative analysis of the cervical spine and spinal cord in a series of affected children. MRI morphometry indicates that the MPS IVA spine is narrower at C1-2 level giving an inverted funnel shape. There is no evidence of a reduction in the Torg ratio (canal-body ratio) in the cervical spine. The spinal canal does not exceed 11 mm at any level, significantly smaller than normal historical cohorts (14 mm). The sagittal diameter and axial surface area of both spinal canal and cord are reduced. C1-2 level cord compression was evident in the canal-cord ratio but the Torg ratio was not predictive of cord compression. In MPS IVA the reduction in the space available for the cord (SAC) is multifactorial rather than due to congenital spinal stenosis. PMID:23404316

  11. MRI morphometric characterisation of the paediatric cervical spine and spinal cord in children with MPS IVA (Morquio-Brailsford syndrome).

    Science.gov (United States)

    Solanki, Guirish A; Lo, William B; Hendriksz, Christian J

    2013-03-01

    Nearly all children with MPS IVA develop skeletal deformities affecting the spine. At the atlanto-axial spine, odontoid hypoplasia occurs. GAG deposition around the dens, leads to peri-odontoid infiltration. Transverse/alar ligament incompetence causes instability. Atlanto-axial instability is associated with cord compression and myelopathy, leading to major morbidity and mortality. Intervention is often required. Does the presence of widened bullet shaped vertebra in platyspondily encroach on the spinal canal and cause spinal stenosis in MPS IVA? So far, there have been no standardised morphometric measurements of the paediatric MPS IVA cervical spine to evaluate whether there is pre-existing spinal stenosis predisposing to compressive myelopathy or whether this is purely an acquired process secondary to instability and compression. This study provides the first radiological quantitative analysis of the cervical spine and spinal cord in a series of affected children. MRI morphometry indicates that the MPS IVA spine is narrower at C1-2 level giving an inverted funnel shape. There is no evidence of a reduction in the Torg ratio (canal-body ratio) in the cervical spine. The spinal canal does not exceed 11 mm at any level, significantly smaller than normal historical cohorts (14 mm). The sagittal diameter and axial surface area of both spinal canal and cord are reduced. C1-2 level cord compression was evident in the canal-cord ratio but the Torg ratio was not predictive of cord compression. In MPS IVA the reduction in the space available for the cord (SAC) is multifactorial rather than due to congenital spinal stenosis.

  12. Microparticles: A New Perspective in Central Nervous System Disorders

    Directory of Open Access Journals (Sweden)

    Stephanie M. Schindler

    2014-01-01

    Full Text Available Microparticles (MPs are a heterogeneous population of small cell-derived vesicles, ranging in size from 0.1 to 1 μm. They contain a variety of bioactive molecules, including proteins, biolipids, and nucleic acids, which can be transferred between cells without direct cell-to-cell contact. Consequently, MPs represent a novel form of intercellular communication, which could play a role in both physiological and pathological processes. Growing evidence indicates that circulating MPs contribute to the development of cancer, inflammation, and autoimmune and cardiovascular diseases. Most cell types of the central nervous system (CNS have also been shown to release MPs, which could be important for neurodevelopment, CNS maintenance, and pathologies. In disease, levels of certain MPs appear elevated; therefore, they may serve as biomarkers allowing for the development of new diagnostic tools for detecting the early stages of CNS pathologies. Quantification and characterization of MPs could also provide useful information for making decisions on treatment options and for monitoring success of therapies, particularly for such difficult-to-treat diseases as cerebral malaria, multiple sclerosis, and Alzheimer’s disease. Overall, studies on MPs in the CNS represent a novel area of research, which promises to expand the knowledge on the mechanisms governing some of the physiological and pathophysiological processes of the CNS.

  13. Modified Projective Synchronization between Different Fractional-Order Systems Based on Open-Plus-Closed-Loop Control and Its Application in Image Encryption

    OpenAIRE

    Hongjuan Liu; Zhiliang Zhu; Hai Yu; Qian Zhu

    2014-01-01

    A new general and systematic coupling scheme is developed to achieve the modified projective synchronization (MPS) of different fractional-order systems under parameter mismatch via the Open-Plus-Closed-Loop (OPCL) control. Based on the stability theorem of linear fractional-order systems, some sufficient conditions for MPS are proposed. Two groups of numerical simulations on the incommensurate fraction-order system and commensurate fraction-order system are presented to justify the theoretic...

  14. Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1.

    Directory of Open Access Journals (Sweden)

    Zhen Dou

    Full Text Available BACKGROUND: Members of the Mps1 kinase family play an essential and evolutionarily conserved role in the spindle assembly checkpoint (SAC, a surveillance mechanism that ensures accurate chromosome segregation during mitosis. Human Mps1 (hMps1 is highly phosphorylated during mitosis and many phosphorylation sites have been identified. However, the upstream kinases responsible for these phosphorylations are not presently known. METHODOLOGY/PRINCIPAL FINDINGS: Here, we identify 29 in vivo phosphorylation sites in hMps1. While in vivo analyses indicate that Aurora B and hMps1 activity are required for mitotic hyper-phosphorylation of hMps1, in vitro kinase assays show that Cdk1, MAPK, Plk1 and hMps1 itself can directly phosphorylate hMps1. Although Aurora B poorly phosphorylates hMps1 in vitro, it positively regulates the localization of Mps1 to kinetochores in vivo. Most importantly, quantitative mass spectrometry analysis demonstrates that at least 12 sites within hMps1 can be attributed to autophosphorylation. Remarkably, these hMps1 autophosphorylation sites closely resemble the consensus motif of Plk1, demonstrating that these two mitotic kinases share a similar substrate consensus. CONCLUSIONS/SIGNIFICANCE: hMps1 kinase is regulated by Aurora B kinase and its autophosphorylation. Analysis on hMps1 autophosphorylation sites demonstrates that hMps1 has a substrate preference similar to Plk1 kinase.

  15. Modular elements of the TPR domain in the Mps1 N terminus differentially target Mps1 to the centrosome and kinetochore.

    Science.gov (United States)

    Marquardt, Joseph R; Perkins, Jennifer L; Beuoy, Kyle J; Fisk, Harold A

    2016-07-12

    Faithful segregation of chromosomes to two daughter cells is regulated by the formation of a bipolar mitotic spindle and the spindle assembly checkpoint, ensuring proper spindle function. Here we show that the proper localization of the kinase Mps1 (monopolar spindle 1) is critical to both these processes. Separate elements in the Mps1 N-terminal extension (NTE) and tetratricopeptide repeat (TPR) domains govern localization to either the kinetochore or the centrosome. The third TPR (TPR3) and the TPR-capping helix (C-helix) are each sufficient to target Mps1 to the centrosome. TPR3 binds to voltage-dependent anion channel 3, but although this is sufficient for centrosome targeting of Mps1, it is not necessary because of the presence of the C-helix. A version of Mps1 lacking both elements cannot localize to or function at the centrosome, but maintains kinetochore localization and spindle assembly checkpoint function, indicating that TPR3 and the C-helix define a bipartite localization determinant that is both necessary and sufficient to target Mps1 to the centrosome but dispensable for kinetochore targeting. In contrast, elements required for kinetochore targeting (the NTE and first two TPRs) are dispensable for centrosomal localization and function. These data are consistent with a separation of Mps1 function based on localization determinants within the N terminus.

  16. A simple electrochemical biosensor based on AuNPs/MPS/Au electrode sensing layer for monitoring carbamate pesticides in real samples.

    Science.gov (United States)

    Song, Yonghai; Chen, Jingyi; Sun, Min; Gong, Coucong; Shen, Yuan; Song, Yonggui; Wang, Li

    2016-03-01

    A simple electrochemical biosensor for quantitative determination of carbamate pesticide was developed based on a sensing interface of citrate-capped gold nanoparticles (AuNPs)/(3-mercaptopropyl)-trimethoxysilane (MPS)/gold electrode (Au). The biosensor was fabricated by firstly assembling three-dimensional (3D) MPS networks on Au electrode and subsequently assembling citrate-capped AuNPs on 3D MPS network via AuS bond. The interface of AuNPs/MPS/Au was negatively charged originating from the citrate coated on AuNPs that would repulse the negatively charged ferricyanide ([Fe(CN)6](3-/4-)) to produce a negative response. In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. The resulted positively charged AuNPs/MPS/Au then attracted the [Fe(CN)6](3-/4-) to produce a positive response. Based on the inhibition of carbamate pesticides on the activity of AChE, the pesticide could be quantitatively determined at a very low potential. The linear range was from 0.003 to 2.00 μM. The sensing platform was also proved to be suitable for carbamate pesticides detection in practical sample.

  17. 77 FR 43071 - MPS Customer Group v. Maine Public Service Company; Notice of Complaint

    Science.gov (United States)

    2012-07-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission MPS Customer Group v. Maine Public Service Company; Notice of Complaint Take... Commission (Commission); 18 CFR 385.206, MPS Customer Group (Complainant) filed a formal complaint...

  18. Human swallowing simulation based on videofluorography images using Hamiltonian MPS method

    Science.gov (United States)

    Kikuchi, Takahiro; Michiwaki, Yukihiro; Kamiya, Tetsu; Toyama, Yoshio; Tamai, Tasuku; Koshizuka, Seiichi

    2015-09-01

    In developed nations, swallowing disorders and aspiration pneumonia have become serious problems. We developed a method to simulate the behavior of the organs involved in swallowing to clarify the mechanisms of swallowing and aspiration. The shape model is based on anatomically realistic geometry, and the motion model utilizes forced displacements based on realistic dynamic images to reflect the mechanisms of human swallowing. The soft tissue organs are modeled as nonlinear elastic material using the Hamiltonian MPS method. This method allows for stable simulation of the complex swallowing movement. A penalty method using metaballs is employed to simulate contact between organ walls and smooth sliding along the walls. We performed four numerical simulations under different analysis conditions to represent four cases of swallowing, including a healthy volunteer and a patient with a swallowing disorder. The simulation results were compared to examine the epiglottic downfolding mechanism, which strongly influences the risk of aspiration.

  19. The relevance and potential roles of microphysiological systems in biology and medicine

    OpenAIRE

    Wikswo, John P.

    2014-01-01

    Microphysiological systems (MPS), consisting of interacting organs-on-chips or tissue-engineered, 3D organ constructs that use human cells, present an opportunity to bring new tools to biology, medicine, pharmacology, physiology, and toxicology. This issue of Experimental Biology and Medicine describes the ongoing development of MPS that can serve as in vitro models for bone and cartilage, brain, gastrointestinal tract, lung, liver, microvasculature, reproductive tract, skeletal muscle, and s...

  20. The safety of anginine in patients undergoing myocardial perfusion scintigraphy (MPS)- a nurses' perspective

    International Nuclear Information System (INIS)

    Full text: Anginine-augmented MPS improves detection rate of myocardial viability and reversible ischaemia. However, anginine can cause significant hypotension. The aims of this study were to determine i) safety of anginine in patients with an intermediate to high risk of myocardial ischaemia undergoing MPS; ii) frequency and degree of fall in systolic blood pressure (SBP); iii) BP monitoring requirements; and iv) type of patient(s) prone to side effects. 63 patients (33M, 30F, mean age-67.2y) were included. Each was cannulated, drank two glasses of water, and lay supine prior to administration of anginine (1 x puff sublingually). 99Tcm-MIBI was administered 3-5 minutes later. BP measurements were obtained every five minutes for 20 minutes. SBP fell in 46/63 patients (range 5 - 40mmHg, mean 1 6mmHg, in 14 fall >20mmHg), and rose in 14/63. Maximal fall occurred 5-15 minutes post-administration of anginine (14 at 5min, 15 at 10min, 17 at 15min), returning toward baseline by 20 minutes in all patients. Seven patients developed a headache and two light-headedness; in all SBP fell >10mmHg. The quality of the scans was unaffected. There were 22(35%) abnormal studies - 14 reversible defects, two fixed defects, six cardiomyopathy (mean SBP tall 8.1mmHg, 8.6mmHg with normal study). LVEF was obtained in 33 patients; SBP fell in 24 (mean LVEF 57.8%), and rose in nine (mean LVEF 56.8%). The frequency and extent of hypotension in relation to age, sex, LVEF, or scan findings was not statistically significant. Anginine is sate to administer to patients undergoing MPS. Careful monitoring of the BP is recommended during the initial 20 minutes post-administration. No particular patient type was identified at higher risk. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

  1. Assurance on the Reliability of Mobile Payment System and Its Effects on Its’ Use: An Empirical Examination

    OpenAIRE

    Priyanka MEHARIA

    2012-01-01

    Mobile Payment Systems (MPS) such as Google Wallet are an emerging technology. This paper examines if mobile assurance as provided by examining the five criteria, namely security, availability, processing integrity, confidentiality and privacy (as per the Trust Framework by the American Institute of Certified Public Accountants (AICPA)) has any relationship with use of MPS. The theory used for this study is technology acceptance model (TAM). Some new measures were developed and validated. The...

  2. Development Expert System

    Institute of Scientific and Technical Information of China (English)

    CAI Heng

    2010-01-01

    The expert system is a high-level technology.It is a sub-field of artificial intelligence.We demonstrated the character and software evaluation,carrying out an initial study of expert system.A good development expert system was developed.

  3. Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.

    Science.gov (United States)

    Althoff, Friederike; Karess, Roger E; Lehner, Christian F

    2012-06-01

    Monopolar spindle 1 (Mps1) is essential for the spindle assembly checkpoint (SAC), which prevents anaphase onset in the presence of misaligned chromosomes. Moreover, Mps1 kinase contributes in a SAC-independent manner to the correction of erroneous initial attachments of chromosomes to the spindle. Our characterization of the Drosophila homologue reveals yet another SAC-independent role. As in yeast, modest overexpression of Drosophila Mps1 is sufficient to delay progression through mitosis during metaphase, even though chromosome congression and metaphase alignment do not appear to be affected. This delay in metaphase depends on the SAC component Mad2. Although Mps1 overexpression in mad2 mutants no longer causes a metaphase delay, it perturbs anaphase. Sister kinetochores barely move apart toward spindle poles. However, kinetochore movements can be restored experimentally by separase-independent resolution of sister chromatid cohesion. We propose therefore that Mps1 inhibits sister chromatid separation in a SAC-independent manner. Moreover, we report unexpected results concerning the requirement of Mps1 dimerization and kinase activity for its kinetochore localization in Drosophila. These findings further expand Mps1's significance for faithful mitotic chromosome segregation and emphasize the importance of its careful regulation.

  4. Maximum Potential Score (MPS: An operating model for a successful customer-focused strategy.

    Directory of Open Access Journals (Sweden)

    Cabello González, José Manuel

    2015-11-01

    Full Text Available One of marketers’ chief objectives is to achieve customer loyalty, which is a key factor for profitable growth. Therefore, they need to develop a strategy that attracts and maintains customers, giving them adequate motives, both tangible (prices and promotions and intangible (personalized service and treatment, to satisfy a customer and make him loyal to the company. Finding a way to accurately measure satisfaction and customer loyalty is very important. With regard to typical Relationship Marketing measures, we can consider listening to customers, which can help to achieve a competitive sustainable advantage. Customer satisfaction surveys are essential tools for listening to customers. Short questionnaires have gained considerable acceptance among marketers as a means to achieve a customer satisfaction measure. Our research provides an indication of the benefits of a short questionnaire (one/three questions. We find that the number of questions survey is significantly related to the participation in the survey (Net Promoter Score or NPS. We also prove that a the three question survey is more likely to have more participants than a traditional survey (Maximum Potential Score or MPS . Our main goal is to analyse one method as a potential predictor of customer loyalty. Using surveys, we attempt to empirically establish the causal factors in determining the satisfaction of customers. This paper describes a maximum potential operating model that captures with a three questions survey, important elements for a successful customer-focused strategy. MPS may give us lower participation rates than NPS but important information that helps to convert unhappy customers or just satisfied customers, into loyal customers.

  5. Residual glycosaminoglycan accumulation in mitral and aortic valves of a patient with attenuated MPS I (Scheie syndrome after 6 years of enzyme replacement therapy: Implications for early diagnosis and therapy

    Directory of Open Access Journals (Sweden)

    Yohei Sato

    2015-12-01

    Full Text Available Mucopolysaccharidosis (MPS is an inherited metabolic disease caused by deficiency of the enzymes needed for glycosaminoglycan (GAG degradation. MPS type I is caused by the deficiency of the lysosomal enzyme alpha-l-iduronidase and is classified into Hurler syndrome, Scheie syndrome, and Hurler–Scheie syndrome based on disease severity and onset. Cardiac complications such as left ventricular hypertrophy, cardiac valve disease, and coronary artery disease are often observed in MPS type I. Enzyme replacement therapy (ERT has been available for MPS type I, but the efficacy of this treatment for cardiac valve disease is unknown. We report on a 56-year-old female patient with attenuated MPS I (Scheie syndrome who developed aortic and mitral stenosis and coronary artery narrowing. The cardiac valve disease progressed despite ERT and she finally underwent double valve replacement and coronary artery bypass grafting. The pathology of the cardiac valves revealed GAG accumulation and lysosomal enlargement in both the mitral and aortic valves. Zebra body formation was also confirmed using electron microscopy. Our results suggest that ERT had limited efficacy in previously established cardiac valve disease. Early diagnosis and initiation of ERT is crucial to avoid further cardiac complications in MPS type I.

  6. Doing Systems Development

    DEFF Research Database (Denmark)

    Koch, Christian; Mathiasen, John Bang

    2014-01-01

    of the indeterminate situation and the systems developers different experience. However, an extreme case reveals initiated learning processes and that the interchanges between materiality of the artefacts and systems developers block the learning processes due to a customer with imprecise demands and unclear system...... specifications. The specific contribution of the paper is the understanding of the individual systems developer’s learning, complemented with the possibility for collective learning and the mechanisms of blocked or derailed learning processes. The practical implications are that managers of systems development......Systems development of wind turbine control is competitive with respect to innovation, time and cost. So how can learning possibly occur under such circumstances? Dewey’s pragmatist approach to learning is adopted, emphasising reciprocity between the systems developer’s individual experience...

  7. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).

    Science.gov (United States)

    Thebault, Philippe; Chirgadze, Dimitri Y; Dou, Zhen; Blundell, Tom L; Elowe, Sabine; Bolanos-Garcia, Victor M

    2012-12-15

    The SAC (spindle assembly checkpoint) is a surveillance system that ensures the timely and accurate transmission of the genetic material to offspring. The process implies kinetochore targeting of the mitotic kinases Bub1 (budding uninhibited by benzamidine 1), BubR1 (Bub1 related) and Mps1 (monopolar spindle 1), which is mediated by the N-terminus of each kinase. In the present study we report the 1.8 Å (1 Å=0.1 nm) crystal structure of the TPR (tetratricopeptide repeat) domain in the N-terminal region of human Mps1. The structure reveals an overall high similarity to the TPR motif of the mitotic checkpoint kinases Bub1 and BubR1, and a number of unique features that include the absence of the binding site for the kinetochore structural component KNL1 (kinetochore-null 1; blinkin), and determinants of dimerization. Moreover, we show that a stretch of amino acids at the very N-terminus of Mps1 is required for dimer formation, and that interfering with dimerization results in mislocalization and misregulation of kinase activity. The results of the present study provide an important insight into the molecular details of the mitotic functions of Mps1 including features that dictate substrate selectivity and kinetochore docking.

  8. Proceedings of the 1st Nordic Optimization Symposium - 10th Nordic MPS meeting, Copenhagen 2006

    DEFF Research Database (Denmark)

    Clausen, Jens; Jørgensen, Rene Munk; Kohl, Niklas;

    2006-01-01

    evolved to be more that just a meeting on Mathematical Programming. They are a forum for discussing a wide range of related areas and practical cases. In the organizing committee we wanted the name of the meeting to reflect this. We have therefore in agreement with the board of the Nordic MPS suggested......On behalf of the Technical University of Denmark, the Danish Operations Research Society and the Nordic Section of the Mathematical Programming Society we welcome you to Copenhagen and the 1st Nordic Optimization Symposium - the 10th meeting of the Nordic MPS. The meetings of the Nordic MPS have...... to add a new title, that reflects the much broader field that is our playground at these meetings. Still the odd trustworthy title “Meeting of the Nordic MPS” has been maintained to demonstrate the origin of the symposium. It is our hope that future Nordic MPS meetings will carry on using this “double...

  9. A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.

    Science.gov (United States)

    Kusakabe, Ken-ichi; Ide, Nobuyuki; Daigo, Yataro; Itoh, Takeshi; Yamamoto, Takahiko; Kojima, Eiichi; Mitsuoka, Yasunori; Tadano, Genta; Tagashira, Sachie; Higashino, Kenichi; Okano, Yousuke; Sato, Yuji; Inoue, Makiko; Iguchi, Motofumi; Kanazawa, Takayuki; Ishioka, Yukichi; Dohi, Keiji; Kido, Yasuto; Sakamoto, Shingo; Ando, Shigeru; Maeda, Masahiro; Higaki, Masayo; Yoshizawa, Hidenori; Murai, Hitoshi; Nakamura, Yusuke

    2015-05-01

    Mps1, also known as TTK, is a dual-specificity kinase that regulates the spindle assembly check point. Increased expression levels of Mps1 are observed in cancer cells, and the expression levels correlate well with tumor grade. Such evidence points to selective inhibition of Mps1 as an attractive strategy for cancer therapeutics. Starting from an aminopyridine-based lead 3a that binds to a flipped-peptide conformation at the hinge region in Mps1, elaboration of the aminopyridine scaffold at the 2- and 6-positions led to the discovery of 19c that exhibited no significant inhibition for 287 kinases as well as improved cellular Mps1 and antiproliferative activities in A549 lung carcinoma cells (cellular Mps1 IC₅₀=5.3 nM, A549 IC₅₀=26 nM). A clear correlation between cellular Mps1 and antiproliferative IC₅₀ values indicated that the antiproliferative activity observed in A549 cells would be responsible for the cellular inhibition of Mps1. The X-ray structure of 19c in complex with Mps1 revealed that this compound retains the ability to bind to the peptide flip conformation. Finally, comparative analysis of the X-ray structures of 19c, a deamino analogue 33, and a known Mps1 inhibitor bound to Mps1 provided insights into the unique binding mode at the hinge region. PMID:25801152

  10. Development of a machine protection system for the Superconducting Beam Test Facility at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Warner, A.; Carmichael, L.; Church, M.; Neswold, R.; /Fermilab

    2011-09-01

    Fermilab's Superconducting RF Beam Test Facility currently under construction will produce electron beams capable of damaging the acceleration structures and the beam line vacuum chambers in the event of an aberrant accelerator pulse. The accelerator is being designed with the capability to operate with up to 3000 bunches per macro-pulse, 5Hz repetition rate and 1.5 GeV beam energy. It will be able to sustain an average beam power of 72 KW at the bunch charge of 3.2 nC. Operation at full intensity will deposit enough energy in niobium material to approach the melting point of 2500 C. In the early phase with only 3 cryomodules installed the facility will be capable of generating electron beam energies of 810 MeV and an average beam power that approaches 40 KW. In either case a robust Machine Protection System (MPS) is required to mitigate effects due to such large damage potentials. This paper will describe the MPS system being developed, the system requirements and the controls issues under consideration.

  11. Diagnosis and treatment trends in mucopolysaccharidosis I: findings from the MPS I Registry

    OpenAIRE

    D’Aco, Kristin; Underhill, Lisa; Rangachari, Lakshmi; Arn, Pamela; Giugliani, Roberto; Okuyama, Torayuki; Wijburg, Frits; Kaplan, Paige; Cox, Gerald Frank

    2012-01-01

    Our objective was to assess how the diagnosis and treatment of mucopolysaccharidosis I (MPS I) have changed over time. We used data from 891 patients in the MPS I Registry, an international observational database, to analyze ages at symptom onset, diagnosis, treatment initiation, and treatment allocation (hematopoietic stem cell transplantation, enzyme replacement therapy with laronidase, both, or neither) over time for all disease phenotypes (Hurler, Hurler–Scheie, and Scheie syndromes). The...

  12. A chemical tool box defines mitotic and interphase roles for Mps1 kinase

    OpenAIRE

    Lan, Weijie; Don W Cleveland

    2010-01-01

    In this issue, three groups (Hewitt et al. 2010. J. Cell Biol. doi:10.1083/jcb.201002133; Maciejowski et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001050; Santaguida et al. 2010. J. Cell Biol. doi:10.1083/jcb.201001036) use chemical inhibitors to analyze the function of the mitotic checkpoint kinase Mps1. These studies demonstrate that Mps1 kinase activity ensures accurate chromosome segregation through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase a...

  13. Cascade Distillation System Development

    Science.gov (United States)

    Callahan, Michael R.; Sargushingh, Miriam; Shull, Sarah

    2014-01-01

    NASA's Advanced Exploration Systems (AES) Life Support System (LSS) Project is chartered with de-veloping advanced life support systems that will ena-ble NASA human exploration beyond low Earth orbit (LEO). The goal of AES is to increase the affordabil-ity of long-duration life support missions, and to re-duce the risk associated with integrating and infusing new enabling technologies required to ensure mission success. Because of the robust nature of distillation systems, the AES LSS Project is pursuing develop-ment of the Cascade Distillation Subsystem (CDS) as part of its technology portfolio. Currently, the system is being developed into a flight forward Generation 2.0 design.

  14. 混合PiN/Schottky二极管的研究%Study of merged PiN/Schottky diode(MPS)

    Institute of Scientific and Technical Information of China (English)

    关艳霞; 李银娜

    2014-01-01

    The main purpose of this paper is to study the merged PiN/Schottky diode (MPS).Firstly,the MPS diode operating principle is analyzed ,Though the volt-ampere characteristics of merged PiN/Schottky diode (MPS)、Schottky diode、PiN diode were simulated,the results show that the MPS diode forward voltage drop is small,current density is big,reverse leakage is small,is a kind of Schottky forward characteristics and PN junction reverse characteristics of the new rectifier. By changing Schottky and PN junction area ratio to adjust the performance of MPS diode,compared with Schottky diode and PiN diode has obvious advantages,is an indispensable power rectifier of power system.%对混合PiN/Schottky二极管(MPS)进行研究,首先对MPS二极管的工作原理进行了分析,通过对MPS二极管、肖特基二极管、PIN二极管的伏安特性进行模拟,结果表明MPS二极管正向压降小,电流密度大,反向漏电流小,是一种具有肖特基正向特性和PN结反向特性的新型整流器。可以通过改变肖特基和PN结的面积比来调整MPS二极管的性能,与肖特基二极管和PIN二极管相比具有明显的优势,是功率系统不可或缺的功率整流管。

  15. Mobile systems development

    DEFF Research Database (Denmark)

    Pedersen, Ole; Kristiansen, Martin Lund; Kammersgaard, Marc N.;

    2007-01-01

    development teams in the mobile software industry. By taking a process view on development of mobile systems we seek to explore the strengths and limitations of eXtreme Programming (XP) in the context of mobile software development. Following an experimental approach a mobile systems development project...... components whenever possible. Test regularly oil real devices, since the difference between emulators and real devices are significant. Take advantage of spikes. Do not use pair programming when spiking, and remember to write unit tests for production code that was initially created during spikes. Monitor...

  16. Industrialized Information Systems Development

    DEFF Research Database (Denmark)

    Havn, Erling; Bansler, Jørgen P.

    1996-01-01

    The production of application software is rapidly being industrialized. Computer manufacturers and software houses produce a rapidly growing number of generic software applications and systems, and more and more user companies choose to build their computer-based information systems with such gen......The production of application software is rapidly being industrialized. Computer manufacturers and software houses produce a rapidly growing number of generic software applications and systems, and more and more user companies choose to build their computer-based information systems...... with such generic products, instead of custom made software. We discuss how the move away from traditional in-house development and the increasing use of generic software is likely to transform IS development in the near future. We conclude that these developments will make new demands on the information systems...

  17. Evolutionary Information System Development

    DEFF Research Database (Denmark)

    Kristensen, Jan

    This paper offers advice to companies and professionals that implement e-commerce systems in business organizations. Implementing e-commerce systems is different from traditional IT implementation and thus requires a new set of tools and skills. The need for a novel approach is illustrated...... of business priorities. On a more theoretical level this suggests that we must revise our current understanding of systems development to cope....

  18. Beam Instrument Development System

    Energy Technology Data Exchange (ETDEWEB)

    2016-01-08

    Beam Instrumentation Development System (BIDS) is a collection of common support libraries and modules developed during a series of Low-Level Radio Frequency (LLRF) control and timing/synchronization projects. BIDS includes a collection of Hardware Description Language (HDL) libraries and software libraries. The BIDS can be used for the development of any FPGA-based system, such as LLRF controllers. HDL code in this library is generic and supports common Digital Signal Processing (DSP) functions, FPGA-specific drivers (high-speed serial link wrappers, clock generation, etc.), ADC/DAC drivers, Ethernet MAC implementation, etc.

  19. Power Systems Development Facility

    Energy Technology Data Exchange (ETDEWEB)

    Southern Company Services

    2009-01-31

    In support of technology development to utilize coal for efficient, affordable, and environmentally clean power generation, the Power Systems Development Facility (PSDF), located in Wilsonville, Alabama, has routinely demonstrated gasification technologies using various types of coals. The PSDF is an engineering scale demonstration of key features of advanced coal-fired power systems, including a Transport Gasifier, a hot gas particulate control device, advanced syngas cleanup systems, and high-pressure solids handling systems. This final report summarizes the results of the technology development work conducted at the PSDF through January 31, 2009. Twenty-one major gasification test campaigns were completed, for a total of more than 11,000 hours of gasification operation. This operational experience has led to significant advancements in gasification technologies.

  20. Assessment of dysmyelination with RAFFn MRI: application to murine MPS I.

    Directory of Open Access Journals (Sweden)

    David Satzer

    Full Text Available Type I mucopolysaccharidosis (MPS I is an autosomal recessive lysosomal storage disorder with neurological features. Humans and laboratory animals with MPS I exhibit various white matter abnormalities involving the corpus callosum and other regions. In this study, we first validated a novel MRI technique, entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn, as a measure of myelination and dysmyelination in mice. We then examined differences between MPS I mice and heterozygotes using RAFF5 and histology. RAFF5 (i.e., RAFFn with n = 5 relaxation time constants were highly correlated with histological myelin density (R2 = 0.68, P<0.001, and RAFF5 clearly distinguished between the hypomyelinated and dysmyelinated shiverer mouse and the wild-type mouse. Bloch-McConnell theoretical analysis revealed slower exchange correlation times and smaller exchange-induced relaxation rate constants for RAFF4 and RAFF5 compared to RAFF1-3, T1ρ, and T2ρ. These data suggest that RAFF5 may assess methylene protons in myelin lipids and proteins, though other mechanisms (e.g. detection of myelin-bound water may also explain the sensitivity of RAFF5 to myelin. In MPS I mice, mean RAFF5 relaxation time constants were significantly larger for the striatum (P = 0.004 and internal capsule (P = 0.039, and marginally larger for the fornix (P = 0.15. Histological assessment revealed no differences between MPS I mice and heterozygotes in myelin density or corpus callosum thickness. Taken together, these findings support subtle dysmyelination in the brains of mice with MPS I. Dysmyelination may result from myelin lipid abnormalities caused by the absence of α-L-iduronidase. Our findings may help to explain locomotor and cognitive deficits seen in mice with MPS I.

  1. Assessment of dysmyelination with RAFFn MRI: application to murine MPS I.

    Science.gov (United States)

    Satzer, David; DiBartolomeo, Christina; Ritchie, Michael M; Storino, Christine; Liimatainen, Timo; Hakkarainen, Hanne; Idiyatullin, Djaudat; Mangia, Silvia; Michaeli, Shalom; Parr, Ann M; Low, Walter C

    2015-01-01

    Type I mucopolysaccharidosis (MPS I) is an autosomal recessive lysosomal storage disorder with neurological features. Humans and laboratory animals with MPS I exhibit various white matter abnormalities involving the corpus callosum and other regions. In this study, we first validated a novel MRI technique, entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn), as a measure of myelination and dysmyelination in mice. We then examined differences between MPS I mice and heterozygotes using RAFF5 and histology. RAFF5 (i.e., RAFFn with n = 5) relaxation time constants were highly correlated with histological myelin density (R2 = 0.68, P<0.001), and RAFF5 clearly distinguished between the hypomyelinated and dysmyelinated shiverer mouse and the wild-type mouse. Bloch-McConnell theoretical analysis revealed slower exchange correlation times and smaller exchange-induced relaxation rate constants for RAFF4 and RAFF5 compared to RAFF1-3, T1ρ, and T2ρ. These data suggest that RAFF5 may assess methylene protons in myelin lipids and proteins, though other mechanisms (e.g. detection of myelin-bound water) may also explain the sensitivity of RAFF5 to myelin. In MPS I mice, mean RAFF5 relaxation time constants were significantly larger for the striatum (P = 0.004) and internal capsule (P = 0.039), and marginally larger for the fornix (P = 0.15). Histological assessment revealed no differences between MPS I mice and heterozygotes in myelin density or corpus callosum thickness. Taken together, these findings support subtle dysmyelination in the brains of mice with MPS I. Dysmyelination may result from myelin lipid abnormalities caused by the absence of α-L-iduronidase. Our findings may help to explain locomotor and cognitive deficits seen in mice with MPS I. PMID:25680196

  2. Hypoxia transiently sequesters mps1 and polo to collagenase-sensitive filaments in Drosophila prometaphase oocytes.

    Directory of Open Access Journals (Sweden)

    William D Gilliland

    Full Text Available BACKGROUND: The protein kinases Mps1 and Polo, which are required for proper cell cycle regulation in meiosis and mitosis, localize to numerous ooplasmic filaments during prometaphase in Drosophila oocytes. These filaments first appear throughout the oocyte at the end of prophase and are disassembled after egg activation. METHODOLOGY/PRINCIPAL FINDINGS: We showed here that Mps1 and Polo proteins undergo dynamic and reversible localization to static ooplasmic filaments as part of an oocyte-specific response to hypoxia. The observation that Mps1- and Polo-associated filaments reappear in the same locations through multiple cycles of oxygen deprivation demonstrates that underlying structural components of the filaments must still be present during normoxic conditions. Using immuno-electron microscopy, we observed triple-helical binding of Mps1 to numerous electron-dense filaments, with the gold label wrapped around the outside of the filaments like a garland. In addition, we showed that in live oocytes the relocalization of Mps1 and Polo to filaments is sensitive to injection of collagenase, suggesting that the structural components of the filaments are composed of collagen-like fibrils. However, the collagen-like genes we have been able to test so far (vkg and CG42453 did not appear to be associated with the filaments, demonstrating that the collagenase-sensitive component of the filaments is one of a number of other Drosophila proteins bearing a collagenase cleavage site. Finally, as hypoxia is known to cause Mps1 protein to accumulate at kinetochores in syncytial embryos, we also show that GFP-Polo accumulates at both kinetochores and centrosomes in hypoxic syncytial embryos. CONCLUSIONS/SIGNIFICANCE: These findings identify both a novel cellular structure (the ooplasmic filaments as well as a new localization pattern for Mps1 and Polo and demonstrate that hypoxia affects Polo localization in Drosophila.

  3. Development of Production Systems

    DEFF Research Database (Denmark)

    Christiansen, Thomas Bøhm

    1997-01-01

    This paper presents the initial considerations related to a Ph.D. study initiated at IPV, DTU in February 1997, concerning the research subject "Development of Production Systems". The content and aim of this paper is to 1) to introduce the study by......This paper presents the initial considerations related to a Ph.D. study initiated at IPV, DTU in February 1997, concerning the research subject "Development of Production Systems". The content and aim of this paper is to 1) to introduce the study by...

  4. UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores.

    Science.gov (United States)

    Zhang, Xiaojuan; Ling, Youguo; Wang, Wenjun; Zhang, Yanhong; Ma, Qingjun; Tan, Pingping; Song, Ting; Wei, Congwen; Li, Ping; Liu, Xuedong; Ma, Runlin Z; Zhong, Hui; Cao, Cheng; Xu, Quanbin

    2013-04-15

    The effect of UV irradiation on replicating cells during interphase has been studied extensively. However, how the mitotic cell responds to UV irradiation is less well defined. Herein, we found that UV-C irradiation (254 nm) increases recruitment of the spindle checkpoint proteins Mps1 and Mad2 to the kinetochore during metaphase, suggesting that the spindle assembly checkpoint (SAC) is reactivated. In accordance with this, cells exposed to UV-C showed delayed mitotic progression, characterized by a prolonged chromosomal alignment during metaphase. UV-C irradiation also induced the DNA damage response and caused a significant accumulation of γ-H2AX on mitotic chromosomes. Unexpectedly, the mitotic delay upon UV-C irradiation is not due to the DNA damage response but to the relocation of Mps1 to the kinetochore. Further, we found that UV-C irradiation activates Aurora B kinase. Importantly, the kinase activity of Aurora B is indispensable for full recruitment of Mps1 to the kinetochore during both prometaphase and metaphase. Taking these findings together, we propose that UV irradiation delays mitotic progression by evoking the Aurora B-Mps1 signaling cascade, which exerts its role through promoting the association of Mps1 with the kinetochore in metaphase.

  5. Mobile systems development

    DEFF Research Database (Denmark)

    Hosbond, Jens Henrik

    2005-01-01

    This paper takes a systems development perspective on mobility, building on preliminary findings of an on-going multiple case study covering 7 companies. The questions driving this paper are: What are the challenges facing development practice in the mobile industry, how do they affect practice...... and how are they dealt with? Analysis of the empirical data is done following a structured and inductive approach. A framework showing the segmentation of the mobile industry into five layers is proposed and challenges are presented according to two dimensions, namely a business dimension...... and a development dimension. Finally, implications stemming from these challenges are discussed and issues inviting for future research are proposed....

  6. Bisphosphonate Treatment in a Patient Affected by MPS IVA with Osteoporotic Phenotype.

    Science.gov (United States)

    Tummolo, Albina; Gabrielli, Orazio; Gaeta, Alberto; Masciopinto, Maristella; Zampini, Lucia; Pavone, Luigi Michele; Di Natale, Paola; Papadia, Francesco

    2013-01-01

    Morquio A syndrome (Mucopolysaccharidosis type IVA) (MPS IVA) is a rare inherited metabolic disorder characterized by the defective degradation of keratan sulfate and chondroitin-6-sulfate. Classically, MPS IVA patients present with severe multisystemic involvement and have a short life expectancy. Attenuated forms with clinical features limited to minor skeletal abnormalities and short stature have also been described, sometimes associated to an early-onset osteoporotic phenotype. No treatment with allogenic bone marrow transplantation or gene therapy is currently available for Morquio A syndrome, and enzyme replacement therapy is under evaluation. We report a case of MPS IVA, who manifested tardily attenuated phenotype and significant bone mass reduction, which was treated with a bisphosphonate (BPN), resulting in an improvement of X-ray skeletal aspects and functional bone performance. We suggest that the use of bisphosphonates may be an interesting supportive therapeutic option for Morquio A patients with osteoporotic phenotype, but further studies involving more patients are necessary to confirm our findings.

  7. Geological disposal system development

    International Nuclear Information System (INIS)

    Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected

  8. Geological disposal system development

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Chul Hyung; Kuh, J. E.; Kim, S. K. and others

    2000-04-01

    Spent fuel inventories to be disposed of finally and design base spent fuel were determined. Technical and safety criteria for a geological repository system in Korea were established. Based on the properties of spent PWR and CANDU fuels, seven repository alternatives were developed and the most promising repository option was selected by the pair-wise comparison method from the technology point of view. With this option preliminary conceptual design studies were carried out. Several module, e.g., gap module, congruent release module were developed for the overall assessment code MASCOT-K. The prominent overseas databases such as OECD/NEA FEP list were are fully reviewed and then screened to identify the feasible ones to reflect the Korean geo-hydrological conditions. In addition to this the well known scenario development methods such as PID, RES were reviewed. To confirm the radiological safety of the proposed KAERI repository concept the preliminary PA was pursued. Thermo-hydro-mechanical analysis for the near field of repository were performed to verify thermal and mechanical stability for KAERI repository system. The requirements of buffer material were analyzed, and based on the results, the quantitative functional criteria for buffer material were established. The hydraulic and swelling property, mechanical properties, and thermal conductivity, the organic carbon content, and the evolution of pore water chemistry were investigated. Based on the results, the candidate buffer material was selected.

  9. Peripheral nervous system neuropathology and progressive sensory impairments in a mouse model of Mucopolysaccharidosis IIIB.

    Directory of Open Access Journals (Sweden)

    Haiyan Fu

    Full Text Available The lysosomal storage pathology in Mucopolysaccharidosis (MPS IIIB manifests in cells of virtually all organs. However, it is the profound role of the neurological pathology that leads to morbidity and mortality in this disease, and has been the major challenge to developing therapies. To date, MPS IIIB neuropathologic and therapeutic studies have focused predominantly on changes in the central nervous system (CNS, especially in the brain, and little is known about the disease pathology in the peripheral nervous system (PNS. This study demonstrates characteristic lysosomal storage pathology in dorsal root ganglia affecting neurons, satellite cells (glia and Schwann cells. Lysosomal storage lesions were also observed in the myoenteric plexus and submucosal plexus, involving enteric neurons with enteric glial activation. Further, MPS IIIB mice developed progressive impairments in sensory functions, with significantly reduced response to pain stimulation that became detectable at 4-5 months of age as the disease progressed. These data demonstrate that MPS IIIB neuropathology manifests not only in the entire CNS but also the PNS, likely affecting both afferent and efferent neural signal transduction. This study also suggests that therapeutic development for MPS IIIB may benefit from targeting the entire nervous system.

  10. Analysis of male reproductive parameters in a murine model of mucopolysaccharidosis type I (MPS I)

    Science.gov (United States)

    do Nascimento, Cinthia Castro; Junior, Odair Aguiar; D’Almeida, Vânia

    2014-01-01

    Mucopolysaccharidosis (MPS) I is a lysosomal storage disorder (LSD) that is characterised by alpha-L-iduronidase (Idua) deficiency and continuous deposition of glycosaminoglycans (GAGs), which consequently interferes with cell signalling mechanisms and results in multisystemic and progressive symptoms. The animal model of MPS I (Idua-/-) has been widely studied to elucidate the consequences and progression of the disorder; however, studies specifically assessing the male reproductive tract are lacking. The aim of this study was to evaluate some of the reproductive characteristics of male MPS I mice in two phases of life. Reproductive organ biometry, sperm counts, sperm morphological evaluation, plasma testosterone measurements and histopathological, histomorphometrical and immunohistochemical analysis were performed in 3- and 6-month-old C57BL/6 Idua+/+ and Idua-/- mice. Seminal vesicle weights were decreased in both the 3- and 6-month-old Idua-/- mice. Decrease in sperm counts and the majority of the histopathological signs were observed in the 6-month-old Idua-/- mice. No differences were detected in the sperm morphological analysis. Immunohistochemistry revealed that seminiferous tubules from 3-month-old Idua-/- mice were more intensely stained with anti-caspase-3 than 3-month-old Idua+/+ mice, but no difference was found at 6 months. These results suggest that MPS I interferes with male reproductive parameters both in 3 and 6-month-old animals and histopathological signs are more pronounced in 6-month-old mice, indicating that the effects of the disorder may intensify with the disease progression. PMID:25031781

  11. Use of the Quest Myocardial Protection System” (MPS) for Modified Ultrafiltration During Pediatric Cardiac Surgery

    OpenAIRE

    Trowbridge, Cody C.; Stammers, Alfred H.; Klayman, Myra H.; Murdock, James D.; Yen, Bianca R.; Gilbert, Christian L.

    2005-01-01

    Modified ultrafiltration generally is considered a standard of care for treating children undergoing cardiopulmonary bypass for congenital heat surgery. Different methods, incorporating a variety of devices and technologies, have been described. The present report describes a technique of modified ultrafiltration using arterial-venous flow with the Quest Myocardial Protection System™ (MPS).

  12. Spectral and fluorescence imaging of immune system and tissue response to an immunogenic agent

    Science.gov (United States)

    Choe, Se-woon; Acharya, Abhinav; Keselowsky, Benjamin G.; Sorg, Brian S.

    2009-05-01

    Imaging of immune system and tissue response to immunogenic agents can be important to the development of new biomaterials. Additionally, quantitative functional imaging can be useful for testing and evaluation of methods to alter or control the immune system response to implanted materials. In this preliminary study, we employ spectral imaging and fluorescence imaging to measure immune system and tissue response to implanted immunogenic agents. Poly (D,L lactide-co-glycolide) (PLGA) with a 50:50 composition was used to create immunogenic microparticles (MPs). Lipopolysaccharide (LPS) encapsulated in the MPs was used to provoke a tissue immune response in mice and encapsulated fluorescein isothiocyanate (FITC) was used to fluorescently label the MPs for imaging. Control MPs did not contain LPS. The MPs were delivered at 50 particles/μL in a total volume of 20μL by subcutaneous injection in the skin of a nude mouse in a dorsal skin-fold window chamber preparation. Cultured immune cells from a mouse leukemic monocyte macrophage cell line were exogenously labeled with the fluorescent dye DiD in solution at a concentration of 8000cells/μL. Immediately after window chamber surgery and implantation of the MPs, 100μL of the fluorescent macrophage solution was administered via the tail vein. Fluorescence imaging was used to track MPs and macrophages while spectral imaging was used for imaging and measurement of hemoglobin saturation in the tissue microvasculature. Imaging was performed periodically over about three days. The spectral and fluorescence imaging combination enabled detailed observations of the macrophage response and functional effects on the tissue.

  13. Power Systems Development Facility

    Energy Technology Data Exchange (ETDEWEB)

    None

    2003-07-01

    This report discusses Test Campaign TC12 of the Kellogg Brown & Root, Inc. (KBR) Transport Gasifier train with a Siemens Westinghouse Power Corporation (SW) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Gasifier is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using a particulate control device (PCD). While operating as a gasifier, either air or oxygen can be used as the oxidant. Test run TC12 began on May 16, 2003, with the startup of the main air compressor and the lighting of the gasifier start-up burner. The Transport Gasifier operated until May 24, 2003, when a scheduled outage occurred to allow maintenance crews to install the fuel cell test unit and modify the gas clean-up system. On June 18, 2003, the test run resumed when operations relit the start-up burner, and testing continued until the scheduled end of the run on July 14, 2003. TC12 had a total of 733 hours using Powder River Basin (PRB) subbituminous coal. Over the course of the entire test run, gasifier temperatures varied between 1,675 and 1,850 F at pressures from 130 to 210 psig.

  14. Power Systems Development Facility

    International Nuclear Information System (INIS)

    The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell

  15. Sepsis and development impede muscle protein synthesis in neonatal pigs by different ribosomal mechanisms

    Science.gov (United States)

    In muscle, sepsis reduces protein synthesis (MPS) by restraining translation in neonates and adults. Even though protein accretion decreases with development as neonatal MPS rapidly declines by maturation, the changes imposed by development on the sepsis-associated decrease in MPS have not been desc...

  16. Advanced Dewatering Systems Development

    Energy Technology Data Exchange (ETDEWEB)

    R.H. Yoon; G.H. Luttrell

    2008-07-31

    A new fine coal dewatering technology has been developed and tested in the present work. The work was funded by the Solid Fuels and Feedstocks Grand Challenge PRDA. The objective of this program was to 'develop innovative technical approaches to ensure a continued supply of environmentally sound solid fuels for existing and future combustion systems with minimal incremental fuel cost.' Specifically, this solicitation is aimed at developing technologies that can (i) improve the efficiency or economics of the recovery of carbon when beneficiating fine coal from both current production and existing coal slurry impoundments and (ii) assist in the greater utilization of coal fines by improving the handling characteristics of fine coal via dewatering and/or reconstitution. The results of the test work conducted during Phase I of the current project demonstrated that the new dewatering technologies can substantially reduce the moisture from fine coal, while the test work conducted during Phase II successfully demonstrated the commercial viability of this technology. It is believed that availability of such efficient and affordable dewatering technology is essential to meeting the DOE's objectives.

  17. The machine protection system for the R&D energy recovery LINAC

    Energy Technology Data Exchange (ETDEWEB)

    Altinbas, Z.; Kayran, D.; Jamilkowski, J.; Lee, R.C.; Oerter, B.

    2011-03-28

    The Machine Protection System (MPS) is a device-safety system that is designed to prevent damage to hardware by generating interlocks, based upon the state of input signals generated by selected sub-systems. It protects all the key machinery in the R&D Project called the Energy Recovery LINAC (ERL) against the high beam current. The MPS is capable of responding to a fault with an interlock signal within several microseconds. The ERL MPS is based on a National Instruments CompactRIO platform, and is programmed by utilizing National Instruments' development environment for a visual programming language. The system also transfers data (interlock status, time of fault, etc.) to the main server. Transferred data is integrated into the pre-existing software architecture which is accessible by the operators. This paper will provide an overview of the hardware used, its configuration and operation, as well as the software written both on the device and the server side.

  18. Power Systems Development Facility

    Energy Technology Data Exchange (ETDEWEB)

    Southern Company Services

    2004-04-30

    This report discusses Test Campaign TC15 of the Kellogg Brown & Root, Inc. (KBR) Transport Gasifier train with a Siemens Power Generation, Inc. (SPG) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The Transport Gasifier is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or gasifier using a particulate control device (PCD). While operating as a gasifier, either air or oxygen can be used as the oxidant. Test run TC15 began on April 19, 2004, with the startup of the main air compressor and the lighting of the gasifier startup burner. The Transport Gasifier was shutdown on April 29, 2004, accumulating 200 hours of operation using Powder River Basin (PRB) subbituminous coal. About 91 hours of the test run occurred during oxygen-blown operations. Another 6 hours of the test run was in enriched-air mode. The remainder of the test run, approximately 103 hours, took place during air-blown operations. The highest operating temperature in the gasifier mixing zone mostly varied from 1,800 to 1,850 F. The gasifier exit pressure ran between 200 and 230 psig during air-blown operations and between 110 and 150 psig in oxygen-enhanced air operations.

  19. POWER SYSTEMS DEVELOPMENT FACILITY

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2002-11-01

    This report discusses test campaign GCT4 of the Kellogg Brown & Root, Inc. (KBR) transport reactor train with a Siemens Westinghouse Power Corporation (Siemens Westinghouse) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The transport reactor is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using one of two possible particulate control devices (PCDs). The transport reactor was operated as a pressurized gasifier during GCT4. GCT4 was planned as a 250-hour test run to continue characterization of the transport reactor using a blend of several Powder River Basin (PRB) coals and Bucyrus limestone from Ohio. The primary test objectives were: Operational Stability--Characterize reactor loop and PCD operations with short-term tests by varying coal-feed rate, air/coal ratio, riser velocity, solids-circulation rate, system pressure, and air distribution. Secondary objectives included the following: Reactor Operations--Study the devolatilization and tar cracking effects from transient conditions during transition from start-up burner to coal. Evaluate the effect of process operations on heat release, heat transfer, and accelerated fuel particle heat-up rates. Study the effect of changes in reactor conditions on transient temperature profiles, pressure balance, and product gas composition. Effects of Reactor Conditions on Synthesis Gas Composition--Evaluate the effect of air distribution, steam/coal ratio, solids-circulation rate, and reactor temperature on CO/CO{sub 2} ratio, synthesis gas Lower Heating Value (LHV), carbon conversion, and cold and hot gas efficiencies. Research Triangle Institute (RTI) Direct Sulfur Recovery Process (DSRP) Testing--Provide syngas in support of the DSRP commissioning. Loop Seal Operations--Optimize loop seal operations and investigate increases to previously achieved maximum solids-circulation rate.

  20. Particle precipitation and mixing simulated by rigid dynamic-moving particle semi-implicit (RD-MPS) method

    International Nuclear Information System (INIS)

    The particle precipitation and mixing related to the corium debris bed formation and coolability in severe accidents are investigated by using a new CFD tool, called the ADDA code. The code is developed based on an enhanced particle method which combines the MPS (Moving Particle Semi-implicit) algorithm with the rigid body dynamics method. The analysis successively simulates the entire process of debris bed formation which includes corium jet breakup, mixing, and sedimentation to identify the key characteristics to form the corium debris bed with coolable configurations. The 2-D and 3-D simulation re-created the detailed flow structures and mixing phenomena and final sedimentation process. For the analysis of the debris formation, it is suggested that the full 3-D simulation provides more accurate prediction than ones from the 2-D simulations since the debris formation largely depends on the process of particle precipitation and mixing phenomena prior to its settlement. (author)

  1. Master Pump Shutdown MPS Software Quality Assurance Plan (SQAP)

    Energy Technology Data Exchange (ETDEWEB)

    BEVINS, R.R.

    2000-09-20

    The MPSS Software Quality Assurance (SQAP) describes the tools and strategy used in the development of the MPSS software. The document also describes the methodology for controlling and managing changes to the software.

  2. Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

    Directory of Open Access Journals (Sweden)

    Mark R. Woodford

    2016-02-01

    Full Text Available The molecular chaperone Hsp90 protects deregulated signaling proteins that are vital for tumor growth and survival. Tumors generally display sensitivity and selectivity toward Hsp90 inhibitors; however, the molecular mechanism underlying this phenotype remains undefined. We report that the mitotic checkpoint kinase Mps1 phosphorylates a conserved threonine residue in the amino-domain of Hsp90. This, in turn, regulates chaperone function by reducing Hsp90 ATPase activity while fostering Hsp90 association with kinase clients, including Mps1. Phosphorylation of Hsp90 is also essential for the mitotic checkpoint because it confers Mps1 stability and activity. We identified Cdc14 as the phosphatase that dephosphorylates Hsp90 and disrupts its interaction with Mps1. This causes Mps1 degradation, thus providing a mechanism for its inactivation. Finally, Hsp90 phosphorylation sensitizes cells to its inhibitors, and elevated Mps1 levels confer renal cell carcinoma selectivity to Hsp90 drugs. Mps1 expression level can potentially serve as a predictive indicator of tumor response to Hsp90 inhibitors.

  3. Circulating microparticles and plasma levels of soluble E- and P-selectins in patients with systemic sclerosis

    DEFF Research Database (Denmark)

    Iversen, Lars; Østergaard, O; Ullman, S;

    2013-01-01

    Microparticles (MPs) may be involved in the pathogenesis of systemic sclerosis (SSc), which includes vasculopathy, endothelial cell activation, and coagulation activation. Circulating MPs from SSc patients were characterized and their relationship with soluble markers of vascular activation inves...

  4. POWER SYSTEMS DEVELOPMENT FACILITY

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2002-05-01

    This report discusses test campaign GCT3 of the Halliburton KBR transport reactor train with a Siemens Westinghouse Power Corporation (Siemens Westinghouse) particle filter system at the Power Systems Development Facility (PSDF) located in Wilsonville, Alabama. The transport reactor is an advanced circulating fluidized-bed reactor designed to operate as either a combustor or a gasifier using one of two possible particulate control devices (PCDs). The transport reactor was operated as a pressurized gasifier during GCT3. GCT3 was planned as a 250-hour test run to commission the loop seal and continue the characterization of the limits of operational parameter variations using a blend of several Powder River Basin coals and Bucyrus limestone from Ohio. The primary test objectives were: (1) Loop Seal Commissioning--Evaluate the operational stability of the loop seal with sand and limestone as a bed material at different solids circulation rates and establish a maximum solids circulation rate through the loop seal with the inert bed. (2) Loop Seal Operations--Evaluate the loop seal operational stability during coal feed operations and establish maximum solids circulation rate. Secondary objectives included the continuation of reactor characterization, including: (1) Operational Stability--Characterize the reactor loop and PCD operations with short-term tests by varying coal feed, air/coal ratio, riser velocity, solids circulation rate, system pressure, and air distribution. (2) Reactor Operations--Study the devolatilization and tar cracking effects from transient conditions during transition from start-up burner to coal. Evaluate the effect of process operations on heat release, heat transfer, and accelerated fuel particle heat-up rates. Study the effect of changes in reactor conditions on transient temperature profiles, pressure balance, and product gas composition. (3) Effects of Reactor Conditions on Syngas Composition--Evaluate the effect of air distribution, steam

  5. Modified Projective Synchronization between Different Fractional-Order Systems Based on Open-Plus-Closed-Loop Control and Its Application in Image Encryption

    Directory of Open Access Journals (Sweden)

    Hongjuan Liu

    2014-01-01

    Full Text Available A new general and systematic coupling scheme is developed to achieve the modified projective synchronization (MPS of different fractional-order systems under parameter mismatch via the Open-Plus-Closed-Loop (OPCL control. Based on the stability theorem of linear fractional-order systems, some sufficient conditions for MPS are proposed. Two groups of numerical simulations on the incommensurate fraction-order system and commensurate fraction-order system are presented to justify the theoretical analysis. Due to the unpredictability of the scale factors and the use of fractional-order systems, the chaotic data from the MPS is selected to encrypt a plain image to obtain higher security. Simulation results show that our method is efficient with a large key space, high sensitivity to encryption keys, resistance to attack of differential attacks, and statistical analysis.

  6. Numerical analysis of jet injection mechanism of fuel-coolant interactions using MPS

    International Nuclear Information System (INIS)

    The numerical method used in this study is Moving Particle Semi-implicit (MPS) method which is based on moving particles and their interactions. Grids are not necessary, so that large fluid deformation can be calculated without numerical diffusion. To understand the fundamental physics of the jet penetration, water jet injection into a pool of a denser fluid under non-boiling and isothermal conditions is calculated using the MPS method. The density ratio of the denser fluid (Fluorinert) to water is 1.88. The calculation results are compared with experiments which were conducted in the ALPHA/MUSE facility at JAERI. In three-dimensional calculation, the penetration behavior agrees with the experiment. It is found that the jet penetration process is divided to two stages and, at the first stage, the coolant jet can penetrate deeper than existing correlations of breakup length. (author)

  7. Developing individuals for developing learning based systems

    OpenAIRE

    Selamat, Mohamad

    2005-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. This research is concerned with investigating the externalisation, sharing and making tangible of tacit knowledge in the context of organisational learning (OL). The externalisation, sharing and making tangible of tacit knowledge can provide “inputs” for Information Systems (IS) development. This process, in turn, can become a basis for the development of a system that is capable of promoting...

  8. Enzyme replacement therapy for Mucopolysaccharidosis Type I among patients followed within the MPS Brazil Network

    Directory of Open Access Journals (Sweden)

    Alícia Dorneles Dornelles

    2014-01-01

    Full Text Available Mucopolysaccharidosis type I (MPS I is a rare lysosomal disorder caused by deficiency of alph-L-iduronidase. Few clinical trials have assessed the effect of enzyme replacement therapy (ERT for this condition. We conducted an exploratory, open-label, non-randomized, multicenter cohort study of patients with MPS I. Data were collected from questionnaires completed by attending physicians at the time of diagnosis (T1; n = 34 and at a median time of 2.5 years later (T2; n = 24/34. The 24 patients for whom data were available at T2 were allocated into groups: A, no ERT (9 patients; median age at T1 = 36 months; 6 with severe phenotype; B, on ERT (15 patients; median age at T1 = 33 months; 4 with severe phenotype. For all variables in which there was no between-group difference at baseline, a delta of ;±20% was considered clinically relevant. The following clinically relevant differences were identified in group B in T2: lower rates of mortality and reported hospitalization for respiratory infection; lower frequency of hepatosplenomegaly; increased reported rates of obstructive sleep apnea syndrome and hearing loss; and stabilization of gibbus deformity. These changes could be due to the effect of ERT or of other therapies which have also been found more frequently in group B. Our findings suggest MPS I patients on ERT also receive a better overall care. ERT may have a positive effect on respiratory morbidity and overall mortality in patients with MPS I. Additional studies focusing on these outcomes and on other therapies should be performed.

  9. CAS and MPS Celebrate the 30th Anniversary of Cooperation in Germany

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Berlin witnesses a grand reunion between Chinese and German scientists to commemorate the 30th anniversary of the rewarding cooperation between the Chinese Academy of Sciences (CAS) and Max Planck Society (MPS) in Germany. A series of celebrations were held on Nov. 8 and 9, 2004 to mark this historic moment,not only renewing old friendships but also seeking new approaches to higher quality of collaboration.

  10. Career Development: A Systems Approach.

    Science.gov (United States)

    Slavenski, Lynn

    1987-01-01

    The author describes a comprehensive career development system implemented by Coca-Cola USA. The system's objectives are (1) to promote from within, (2) to develop talent for the future, (3) to make managers responsible for development efforts, and (4) to make individuals ultimately responsible for their development. (CH)

  11. The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline.

    Science.gov (United States)

    Sutherland, Margaret L; Fabre, Kristin M; Tagle, Danilo A

    2013-01-01

    The National Institutes of Health has partnered with the US Food and Drug Administration and the Defense Advanced Research Projects Agency to accelerate the development of human microphysiological systems (MPS) that address challenges faced in predictive toxicity assessment and efficacy analysis of new molecular entities during the preclinical phase of drug development. Use of human MPS could provide better models for predicting the efficacy of new molecular entities in clinical trials. It is also anticipated that improvements in predicting drug toxicities early in the drug development process through the use of MPS or human organs-on-a-chip will decrease the need to withdraw new therapies from the market and minimize or eliminate deaths due to unidentified drug toxicities.

  12. Framework for control system development

    International Nuclear Information System (INIS)

    Control systems being developed for the present generation of accelerators will need to adapt to changing machine and operating state conditions. Such systems must also be capable of evolving over the life of the accelerator operation. In this paper we present a framework for the development of adaptive control systems

  13. Arcjet system integration development

    Science.gov (United States)

    Zafran, Sidney

    1994-03-01

    Compatibility between an arcjet propulsion system and a communications satellite was verified by testing a Government-furnished, 1.4 kW hydrazine arcjet system with the FLTSATCOM qualification model satellite in a 9.1-meter (30-foot) diameter thermal-vacuum test chamber. Background pressure was maintained at 10(exp -5) torr during arcjet operation by cryopumping the thruster exhaust with an array of 5 K liquid helium cooled panels. Power for the arcjet system was obtained from the FLTSATCOM battery simulator. Spacecraft telemetry was monitored during each thruster firing period. No changes in telemetry data attributable to arcjet operation were detected in any of the tests. Electromagnetic compatibility data obtained included radiated emission measurements, conducted emission measurements, and cable coupling measurements. Significant noise was observed at lower frequencies. Above 500 MHz, radiated emissions were generally within limits, indicating that communication links at S-band and higher frequencies will not be affected. Other test data taken with a diagnostic array of calorimeters, radiometers, witness plates, and a residual gas analyzer evidenced compatible operation, and added to the data base for arcjet system integration. Two test series were conducted. The first series only included the arcjet and diagnostic array operating at approximately 0.1 torr background pressure. The second series added the qualification model spacecraft, a solar panel, and the helium cryopanels. Tests were conducted at 0.1 torr and 10(exp-5) torr. The arcjet thruster was canted 20 degrees relative to the solar panel axis, typical of the configuration used for stationkeeping thrusters on geosynchronous communications satellites.

  14. Liferay Portal Systems Development

    CERN Document Server

    Yuan, Jonas X

    2012-01-01

    This book focuses on teaching by example. Every chapter provides an overview, and then dives right into hands-on examples so you can see and play with the solution in your own environment. This book is for Java developers who don't need any prior experience with Liferay portal. Although Liferay portal makes heavy use of open source frameworks, no prior experience of using these is assumed.

  15. The Guided System Development Framework

    DEFF Research Database (Denmark)

    Carvalho Quaresma, Jose Nuno; Probst, Christian W.; Nielson, Flemming

    2011-01-01

    The Service-Oriented Computing paradigm has had significant influence on the Internet. With the emergence of this paradigm, it is important to provide tools that help developers designing and verifying such systems. In this article, we present the Guided System Development (GSD) Framework that aids...... and guides the developer on the specification of the system being developed, on choosing the appropriate standard protocols suites that achieve the required security properties, on providing an implementation of the specified system, and also on allowing the verification of its security properties....

  16. MEASUREMENT PROCESS OF SOFTWARE DEVELOPMENT PROJECTS FOR SUPPORTING STRATEGIC BUSINESS OBJECTIVES IN SOFTWARE DEVELOPING COMPANIES

    OpenAIRE

    Sandra Lais Pedroso; Leonardo Rocha de Oliveira

    2013-01-01

    Software developing companies work in a competitive market and are often challenged to make business decisions with impact on competitiveness. Models accessing maturity for software development processes quality, such as CMMI and MPS-BR, comprise process measurements systems (PMS). However, these models are not necessarily suitable to support business decisions, neither to achieve strategic goals. The objective of this work is to analyze how the PMS of software development projects could supp...

  17. HLW Disposal System Development

    Energy Technology Data Exchange (ETDEWEB)

    Choi, J. W.; Choi, H. J.; Lee, J. Y. (and others)

    2007-06-15

    A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm{sup 3}. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability

  18. HLW Disposal System Development

    International Nuclear Information System (INIS)

    A KRS is suggested through design requirement analysis of the buffer and the canister which are the constituent of disposal system engineered barrier and HLW management plans are proposed. In the aspect of radionuclide retention capacity, the thickness of the buffer is determined 0.5m, the shape to be disc and ring and the dry density to be 1.6 g/cm3. The maximum temperature of the buffer is below 100 .deg. which meets the design requirement. And bentonite blocks with 5 wt% of graphite showed more than 1.0 W/mK of thermal conductivity without the addition of sand. The result of the thermal analysis for proposed double-layered buffer shows that decrease of 7 .deg. C in maximum temperature of the buffer. For the disposal canister, the copper for the outer shell material and cast iron for the inner structure material is recommended considering the results analyzed in terms of performance of the canisters and manufacturability and the geochemical properties of deep groundwater sampled from the research area with granite, salt water intrusion, and the heavy weight of the canister. The results of safety analysis for the canister shows that the criticality for the normal case including uncertainty is the value of 0.816 which meets subcritical condition. Considering nation's 'Basic Plan for Electric Power Demand and Supply' and based on the scenario of disposing CANDU spent fuels in the first phase, the disposal system that the repository will be excavated in eight phases with the construction of the Underground Research Laboratory (URL) beginning in 2020 and commissioning in 2040 until the closure of the repository is proposed. Since there is close correlation between domestic HLW management plans and front-end/back-end fuel cycle plans causing such a great sensitivity of international environment factor, items related to assuring the non-proliferation and observing the international standard are showed to be the influential factor and acceptability of HLW management

  19. Development of FAME Animation System

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Yukihiro; Hamamatsu, Kiyotaka; Shirai, Hiroshi; Matsuda, Toshiaki [Department of Fusion Plasma Research, Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka, Ibaraki (Japan); Watanabe, Hideto; Itakura, Hirofumi; Tahata, Yasunori

    1999-02-01

    In order to monitor an animation of magnetohydrodynamic equilibrium calculated by the FAME-II (Fast Analyzer for Magnetohydrodynamic Equilibrium-II) system, a FAME Animation System was developed. This system provides automatically the animation on workstations connected to network with the same period of JT-60U discharge sequence. Then, the system can supply the important information for JT-60U operators to determine control parameters of the succeeding discharge. This report describes the overview of the FAME Animation System. (author)

  20. Collaborative development of embedded systems

    NARCIS (Netherlands)

    Verhoef, Marcel; Pierce, Kenneth; Gamble, Carl; Broenink, Jan; Fitzgerald, John; Larsen, Peter Gorm; Verhoef, Marcel

    2014-01-01

    This chapter presents motivation for taking a collaborative multi-disciplinary approach to the model-based development of embedded systems. Starting from a consideration of the ubiquity of embedded systems in daily life it identifies challenges faced by industry in developing products in a timely ma

  1. ISE System Development Methodology Manual

    Energy Technology Data Exchange (ETDEWEB)

    Hayhoe, G.F.

    1992-02-17

    The Information Systems Engineering (ISE) System Development Methodology Manual (SDM) is a framework of life cycle management guidelines that provide ISE personnel with direction, organization, consistency, and improved communication when developing and maintaining systems. These guide-lines were designed to allow ISE to build and deliver Total Quality products, and to meet the goals and requirements of the US Department of Energy (DOE), Westinghouse Savannah River Company, and Westinghouse Electric Corporation.

  2. Development of a multifunctional particle spectrometer for space radiation imaging

    International Nuclear Information System (INIS)

    For future exploration of the solar system, the European Space Agency (ESA) is planning missions to Mercury (BepiColombo), the Sun (SolarOrbiter) and to the moons of Jupiter and Saturn. The expected intensity of radiation during such missions is hazardous for the scientific instruments and the satellite. To extend the lifetime of the satellite and its payload a multifunctional particle spectrometer (MPS) is being developed. The basic function of the MPS is to send an alarm signal to the satellite control system during periods of high radiation. In addition the MPS is a scientific instrument that will unfold the composition of the different contributing particles on-line by the dE/dx versus E method. The energy spectrum and angular distribution of the particles will be recorded as well. This article describes the main requirements and the base line design for the MPS. A readout scheme consisting of a 32 channel ASIC from IDEAS is proposed and the signal filtering algorithm will run on a digital signal processor based on FPGA technology. Results are shown from prototype calibration studies with a proton beam

  3. Development of cooperative system bridges

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhe; WAN Qi-bai; SHI Lei

    2008-01-01

    Cooperative system bridges comprise several basic structures that act jointly to improve structural characteristics. We delved into the historical development of cooperative system bridges. Cooperative systems are classified as different-load cooperative systems and same-load cooperative systems by distinguishing the modes of load distribution. For different-load cooperation, individual basic structures are at different positions in the direction along bridge axis and carry the loads separately. While for same-load cooperation, all basic structures overlap in geometrical locations and support the entire loads conjointly. The choosing of span ratios between basic structures, the design of connections of different-load cooperative systems were discussed as well as optimizations of relative rigidity for same-load cooperative systems which greatly influence structural characteristics. The general situation and several structural measurements of several cooperative bridges were demonstrated. This information can assist engineers in developing their concepts in cooperative systems and can lead to more efficient and economical cooperative bridges.

  4. Development of televoting information system

    OpenAIRE

    Lesjak, Miran

    2008-01-01

    Purpose of this paper is to present an approach of developing a Televoting information system. The main goal of the system is to simplify management of televoting events and to assure fast and simple control over televoting events and statistics. In the first part we represent Adobe Flash technology, MySQL relational database management system, Typo3 Content Management System, PHP scripting language, Microsoft Visual Studio Studio 2008, C# programming language and Rational Rose (a too...

  5. Information system development activities and inquiring systems

    DEFF Research Database (Denmark)

    Carugati, Andrea

    2008-01-01

    This article presents a framework that maps information system development (ISD) activities on systems for the creation of knowledge. This work addresses the relevant and persisting problem of improving the chances of ISD success. The article builds upon previous research on knowledge aspects...... of ISD, abandoning the idea of a monolithic approach to knowledge and presenting a pluralistic approach based on the idea that different inquiring systems can support micro-level ISD activities. The article is divided into two parts. The first part presents the theoretical development of the framework...... based on ISD literature and on Churchman's (1971) inquiring systems. The second part presents the use of the framework in an ISD project. The case is used to show the applicability of the framework and to highlight the advantages of this approach. The main theoretical implication is that the framework...

  6. Developing an Environmental Scanning System.

    Science.gov (United States)

    Morrison, James L.

    A step-by-step approach is provided for developing an environmental scanning system for colleges and universities to assist them in planning for the future. The objectives of such a system are to detect social, scientific, economic, technical, and political interactions important to the organization; define potential threats and opportunities from…

  7. TADS: Technical Assistance Development System.

    Science.gov (United States)

    Epting, Rosemary, Ed.

    Described is the Technical Assistance Development System (TADS), a component of the Frank Porter Graham Child Development Center of the University of North Carolina at Chapel Hill which offers support services to preschool demonstration centers for handicapped children in the First Chance Network. Discussed are the four types of services offered:…

  8. DEVELOPMENT OF VEHICLES RECYCLING SYSTEM

    OpenAIRE

    PAWE£ SMOLNIK

    2014-01-01

    Fast development of automotive industry in Poland in recent years involves the need for rational waste management from the destruction and exploitation of vehicles. Rising number of new cars in Poland and existing age structure of the domestic park of vehicles will contribute to the increase number cars withdrawn from use. The way to solve the growing problem of waste recycling is the development of vehicles recycling system which contributes to the economic management of natural resources an...

  9. Social networks, politics and Commitment 2.0: Spanish MPs on Facebook

    Directory of Open Access Journals (Sweden)

    José Sixto, B.A.

    2011-01-01

    Full Text Available In a technologically and sociologically advanced society, the organizations that do not use the new media and the cyber communication techniques are probably doomed to failure. In this virtual sphere the social networks constitute a suitable resource and channel for the implementation of political marketing 2.0, as it provides a scenario where the interaction with users is possible. From this perspective, we verified their presence of the 350 members of the Spanish Congress on Facebook, the country’s most popular social network, in order to establish the predominant typologies, updating frequency, contents, resources, and the types of information posted in this spaces.This article also examines the interactivity of MPs in what we have termed Commitment 2.0: political communication in personal contexts such as social networks requires going from the participatory attitude to the participatory action; that is, to accept the interaction 2.0 as the correct behaviour on the network.

  10. Open quantum systems recent developments

    CERN Document Server

    Joye, Alain; Pillet, Claude-Alain

    2006-01-01

    Understanding dissipative dynamics of open quantum systems remains a challenge in mathematical physics. This problem is relevant in various areas of fundamental and applied physics. From a mathematical point of view, it involves a large body of knowledge. Significant progress in the understanding of such systems has been made during the last decade. These books present in a self-contained way the mathematical theories involved in the modeling of such phenomena. They describe physically relevant models, develop their mathematical analysis and derive their physical implications. In Volume I the Hamiltonian description of quantum open systems is discussed. This includes an introduction to quantum statistical mechanics and its operator algebraic formulation, modular theory, spectral analysis and their applications to quantum dynamical systems. Volume II is dedicated to the Markovian formalism of classical and quantum open systems. A complete exposition of noise theory, Markov processes and stochastic differential...

  11. Development of Moving Particle Simulation Method for Multiliquid-Layer Sloshing

    Directory of Open Access Journals (Sweden)

    Kyung Sung Kim

    2014-01-01

    Full Text Available The mixed oil and gas including water and sand are extracted from well to offshore structure. This mixed fluid must be separated for subsequent processes by using wash tanks or separators. To design such a system, a proper numerical-prediction tool for multiphase fluids is required. In this regard, a new moving particle simulation (MPS method is developed to simulate multiliquid-layer sloshing problems. The new MPS method for multifluid system includes extra search methods for interface particles, boundary conditions for interfaces, buoyancy-correction model, and surface-tension model for interface particles. The new particle interaction models are verified through comparisons with published numerical and experimental data. In particular, the multiliquid MPS method is verified against Molin et al’s (2012 experiment with three liquid layers. In case of excitation frequency close to one of the internal-layer resonances, the internal interface motions can be much greater than top free-surface motions. The verified multiliquid MPS program is subsequently used for more nonlinear cases including multichromatic multimodal motions with larger amplitudes, from which various nonlinear features, such as internal breaking and more particle detachment, can be observed. For the nonlinear case, the differences between with and without buoyancy-correction and surface-tension models are also demonstrated.

  12. Networking systems design and development

    CERN Document Server

    Chao, Lee

    2009-01-01

    Effectively integrating theory and hands-on practice, Networking Systems Design and Development provides students and IT professionals with the knowledge and skills needed to design, implement, and manage fully functioning network systems using readily available Linux networking tools. Recognizing that most students are beginners in the field of networking, the text provides step-by-step instruction for setting up a virtual lab environment at home. Grounded in real-world applications, this book provides the ideal blend of conceptual instruction and lab work to give students and IT professional

  13. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.

    Science.gov (United States)

    Slee, Roger B; Grimes, Brenda R; Bansal, Ruchi; Gore, Jesse; Blackburn, Corinne; Brown, Lyndsey; Gasaway, Rachel; Jeong, Jaesik; Victorino, Jose; March, Keith L; Colombo, Riccardo; Herbert, Brittney-Shea; Korc, Murray

    2014-02-01

    Most solid tumors, including pancreatic ductal adenocarcinoma (PDAC), exhibit structural and numerical chromosome instability (CIN). Although often implicated as a driver of tumor progression and drug resistance, CIN also reduces cell fitness and poses a vulnerability that can be exploited therapeutically. The spindle assembly checkpoint (SAC) ensures correct chromosome-microtubule attachment, thereby minimizing chromosome segregation errors. Many tumors exhibit upregulation of SAC components such as MPS1, which may help contain CIN within survivable limits. Prior studies showed that MPS1 inhibition with the small molecule NMS-P715 limits tumor growth in xenograft models. In cancer cell lines, NMS-P715 causes cell death associated with impaired SAC function and increased chromosome missegregation. Although normal cells appeared more resistant, effects on stem cells, which are the dose-limiting toxicity of most chemotherapeutics, were not examined. Elevated expression of 70 genes (CIN70), including MPS1, provides a surrogate measure of CIN and predicts poor patient survival in multiple tumor types. Our new findings show that the degree of CIN70 upregulation varies considerably among PDAC tumors, with higher CIN70 gene expression predictive of poor outcome. We identified a 25 gene subset (PDAC CIN25) whose overexpression was most strongly correlated with poor survival and included MPS1. In vitro, growth of human and murine PDAC cells is inhibited by NMS-P715 treatment, whereas adipose-derived human mesenchymal stem cells are relatively resistant and maintain chromosome stability upon exposure to NMS-P715. These studies suggest that NMS-P715 could have a favorable therapeutic index and warrant further investigation of MPS1 inhibition as a new PDAC treatment strategy.

  14. Implementation of alarm system for vibration monitoring of KOMAC facility

    International Nuclear Information System (INIS)

    For operating 100 MeV linac, Devices have to be operated in certain order. Thus malfunction of a device cause damage to linac and related devices. To protect linac, machine protect system (MPS) has been developed. The MPS protects the components by monitoring hardwired signals. When values of operating parameters go beyond or below limit, alarm will be generated and interlock system which stops related devices in certain sequence will run. Other factor, giving damage to linac is disaster. A strong vibration such as earthquake causes malfunction of devices and damage to linac. Against disaster, the monitoring system based on Experimental Physics and Industrial Control System (EPICS) was implemented. Configuration and Implementation of the monitoring system are presented and some preliminary results are reported. KOMAC implemented alarm system for a strong vibration and fire. Alarm is generated in unusual situation. Coping rapidly with situation, damages for Linac and related devices can be reduced

  15. Negotiating a Systems Development Method

    Science.gov (United States)

    Karlsson, Fredrik; Hedström, Karin

    Systems development methods (or methods) are often applied in tailored version to fit the actual situation. Method tailoring is in most the existing literature viewed as either (a) a highly rational process with the method engineer as the driver where the project members are passive information providers or (b) an unstructured process where the systems developer makes individual choices, a selection process without any driver. The purpose of this chapter is to illustrate that important design decisions during method tailoring are made by project members through negotiation. The study has been carried out using the perspective of actor-network theory. Our narratives depict method tailoring as more complex than (a) and (b) show the driver role rotates between the project members, and design decisions are based on influences from several project members. However, these design decisions are not consensus decisions.

  16. A Study on the Management of Micropollutants in Water System Considering Climate Change and other Potential Effects

    International Nuclear Information System (INIS)

    In this study, the management polices of micropollutants (MPs) were reviewed and the future management strategy was discussed considering climate change and etc. In Korea, the investigation of drinking water has been actively carried out for the priority contaminants as well as MPs. Recently river and lake waters have been also examined for MPs. However, the coverage and depth of the investigation is limited. Moreover, climate change is likely to increase air, water temperature and it will affect the hydrological cycle. Such changes may increase the residual concentrations of MPs in water system. As water reuse increases, the residual MPs of the recycled water may create public concerns. Thus, in a viewpoint of the precautionary principle, more stringent management of MPs is recommended for the drinking water and the body-contact water use. For the surface water, more studies are necessary to understand the ecological risk by MPs

  17. A Study on the Management of Micropollutants in Water System Considering Climate Change and other Potential Effects

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hojeong; Ahn, Jong Ho [Korea Environment Institute (KEI), Seoul (Korea, Republic of); Hong, Yongsuk [Korea University, Sejong (Korea, Republic of)

    2013-12-15

    In this study, the management polices of micropollutants (MPs) were reviewed and the future management strategy was discussed considering climate change and etc. In Korea, the investigation of drinking water has been actively carried out for the priority contaminants as well as MPs. Recently river and lake waters have been also examined for MPs. However, the coverage and depth of the investigation is limited. Moreover, climate change is likely to increase air, water temperature and it will affect the hydrological cycle. Such changes may increase the residual concentrations of MPs in water system. As water reuse increases, the residual MPs of the recycled water may create public concerns. Thus, in a viewpoint of the precautionary principle, more stringent management of MPs is recommended for the drinking water and the body-contact water use. For the surface water, more studies are necessary to understand the ecological risk by MPs.

  18. Remote Arrhythmia Monitoring System Developed

    Science.gov (United States)

    York, David W.; Mackin, Michael A.; Liszka, Kathy J.; Lichter, Michael J.

    2004-01-01

    Telemedicine is taking a step forward with the efforts of team members from the NASA Glenn Research Center, the MetroHealth campus of Case Western University, and the University of Akron. The Arrhythmia Monitoring System is a completed, working test bed developed at Glenn that collects real-time electrocardiogram (ECG) signals from a mobile or homebound patient, combines these signals with global positioning system (GPS) location data, and transmits them to a remote station for display and monitoring. Approximately 300,000 Americans die every year from sudden heart attacks, which are arrhythmia cases. However, not all patients identified at risk for arrhythmias can be monitored continuously because of technological and economical limitations. Such patients, who are at moderate risk of arrhythmias, would benefit from technology that would permit long-term continuous monitoring of electrical cardiac rhythms outside the hospital environment. Embedded Web Technology developed at Glenn to remotely command and collect data from embedded systems using Web technology is the catalyst for this new telemetry system (ref. 1). In the end-to-end system architecture, ECG signals are collected from a patient using an event recorder and are transmitted to a handheld personal digital assistant (PDA) using Bluetooth, a short-range wireless technology. The PDA concurrently tracks the patient's location via a connection to a GPS receiver. A long distance link is established via a standard Internet connection over a 2.5-generation Global System for Mobile Communications/General Packet Radio Service (GSM/GPRS)1 cellular, wireless infrastructure. Then, the digital signal is transmitted to a call center for monitoring by medical professionals.

  19. ITER Plasma Control System Development

    Science.gov (United States)

    Snipes, Joseph; ITER PCS Design Team

    2015-11-01

    The development of the ITER Plasma Control System (PCS) continues with the preliminary design phase for 1st plasma and early plasma operation in H/He up to Ip = 15 MA in L-mode. The design is being developed through a contract between the ITER Organization and a consortium of plasma control experts from EU and US fusion laboratories, which is expected to be completed in time for a design review at the end of 2016. This design phase concentrates on breakdown including early ECH power and magnetic control of the poloidal field null, plasma current, shape, and position. Basic kinetic control of the heating (ECH, ICH, NBI) and fueling systems is also included. Disruption prediction, mitigation, and maintaining stable operation are also included because of the high magnetic and kinetic stored energy present already for early plasma operation. Support functions for error field topology and equilibrium reconstruction are also required. All of the control functions also must be integrated into an architecture that will be capable of the required complexity of all ITER scenarios. A database is also being developed to collect and manage PCS functional requirements from operational scenarios that were defined in the Conceptual Design with links to proposed event handling strategies and control algorithms for initial basic control functions. A brief status of the PCS development will be presented together with a proposed schedule for design phases up to DT operation.

  20. Development of logistics information systems

    Directory of Open Access Journals (Sweden)

    Milan Ž. Dronjak

    2012-10-01

    -Army (Global Combat Support System-Army Field/Tactical, is intended for the tactical level and it will replace 14 tactical logistics information systems and connect them with the rest of the information environment. Tendencies in the development of logistics information systems In line with the presented information solutions, it is possible to extract relevant conclusions about tendencies in the development of these types of systems all around the world. These conclusions should be implemented, through adequate principles, into domestic software development. Three main tendencies are visible in modern solutions: using centralised databases, integration of existing separated software solutions, and connecting previously autonomus systems. Conclusion In accordance with present time requirements, logistic support should be realised as close as possible to the origin of a logistic need, in real time and adequately. Information systems enable real time delivery of information needed for a quality logistic support in all phases of operations as well as for a faster generation of all types of documents.

  1. StaMPS Improvement for Deformation Analysis in Mountainous Regions: Implications for the Damavand Volcano and Mosha Fault in Alborz

    Directory of Open Access Journals (Sweden)

    Sanaz Vajedian

    2015-06-01

    Full Text Available Interferometric Synthetic Aperture Radar (InSAR capability to detect slow deformation over terrain areas is limited by temporal decorrelation, geometric decorrelation and atmospheric artefacts. Multitemporal InSAR methods such as Persistent Scatterer (PS-InSAR and Small Baseline Subset (SBAS have been developed to deal with various aspects of decorrelation and atmospheric problems affecting InSAR observations. Nevertheless, the applicability of both PS-InSAR and SBAS in mountainous regions is still challenging. Correct phase unwrapping in both methods is hampered due to geometric decorrelation in particular when using C-band SAR data for deformation analysis. In this paper, we build upon the SBAS method implemented in StaMPS software and improved the technique, here called ISBAS, to assess tectonic and volcanic deformation in the center of the Alborz Mountains in Iran using both Envisat and ALOS SAR data. We modify several aspects within the chain of the processing including: filtering prior to phase unwrapping, topographic correction within three-dimensional phase unwrapping, reducing the atmospheric noise with the help of additional GPS data, and removing the ramp caused by ionosphere turbulence and/or orbit errors to better estimate crustal deformation in this tectonically active region. Topographic correction is done within the three-dimensional unwrapping in order to improve the phase unwrapping process, which is in contrast to previous methods in which DEM error is estimated before/after phase unwrapping. Our experiments show that our improved SBAS approach is able to better characterize the tectonic and volcanic deformation in the center of the Alborz region than the classical SBAS. In particular, Damavand volcano shows an average uplift rate of about 3 mm/year in the year 2003–2010. The Mosha fault illustrates left-lateral motion that could be explained with a fault that is locked up to 17–18 km depths and slips with 2–4 mm

  2. KSTAR RF heating system development

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, J. G.; Kim, S. K.; Hwang, C. K. (and others)

    2007-10-15

    Design, high-voltage test, and installation of 6 MW ICRF heating system for KSTAR is completed. The antenna demonstrated satisfactory standoff at high voltages up to 41 kV for 300 sec. The result indicates good power handling capabilities of the antenna as high as 10 MW/m2. This power density is equivalent to RF power coupling of 6 MW into a 4 {omega}/m target plasma, and is typical of advanced tokamak heating scenarios. In addition, vacuum feed through, DC break, and liquid stub developed for 300 sec operation are installed, as well as a 2 MW, 30-60MHz transmitter. The transmitter successfully produced output powers of 600 kW continuously, 1.5{approx}1.8 MW for 300 sec, and 2 MW for 100 msec or shorter pulses. A realtime control system based on DSP and EPICS is developed, installed, and tested on the ICRF system. Initial results from feasibility study indicate that the present antenna and the transmission lines could allow load-resilient operation on KSTAR. Until the KSTAR tokamak start to produce plasmas in 2008, however, hands-on operational experiences are obtained from participating in ICRF heating experiments at ASDEX and DIII-D tokamaks arranged through international cooperation.

  3. Expert system development (ESD) shell

    International Nuclear Information System (INIS)

    An Expert System Development (ESD) Shell design implementation is desribed in detail. The shell provides high-level generic facilities for Knowledge Representation (KR) and inferencing and tools for developing user interfaces. Powerful set of tools in the shell relieves much of the programming burden in the ES development. The shell is written in PROLOG under IBM PC/AT. KR facilities are based on two very powerful formalisms namely, frames and rules. Inference Engine (IE) draws most of its power from unification and backward reasoning strategy in PROLOG. This basic mechanism is enhanced further by incorporating both forward and backward chaining of rules and frame-based inferencing. Overall programming style integrates multiple paradigms including logic, object oriented, access-oriented and imperative programming. This permits ES designer a lot of flexibility in organizing inference control. Creation and maintainance of knowledge base is a major activity. The shell, therefore, provides number of facilities to simplify these tasks. Shell design also takes note of the fact that final success of any system depends on end-user satisfaction and hence provides features to build use-friendly interfaces. The shell also provides a set of interfacing predicates so that it can be embedded within any PROLOG program to incorporate functionalilty of the shell in the user program. (author). 10 refs., 8 figs

  4. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS model: a pollen production model for regional emission and transport modeling

    Directory of Open Access Journals (Sweden)

    T. R. Duhl

    2013-04-01

    Full Text Available A pollen model that simulates the timing and production of wind-dispersed allergenic pollen by terrestrial, temperate vegetation has been developed to quantify how pollen occurrence may be affected by climate change and to investigate how pollen can interact with anthropogenic pollutants to affect human health. The Simulator of the Timing and Magnitude of Pollen Season (STaMPS model is driven by local meteorological conditions and is designed to be sensitive to climate shifts, as well as flexible with respect to the vegetation species and plant functional types (trees, grasses, etc. represented and the climate zones simulated. The initial focus for the model is the simulation of the pollen emission potential of important allergenic tree and grass species that typically flower between March–June in Southern California (S. CA, which is characterized by moderate Mediterranean and oceanic climate zones as well as regions of arid desert and arid steppe. Vegetation cover and species composition data are obtained from numerous datasets and a database of allergenic vegetation species, their pollen production potential and relative allergenicities has been developed. For the selected allergenic species and spring-early summer simulation period, temperature is the main driver controlling the timing of pollen release, while precipitation (and temperature, for some species controls the magnitude of pollen produced. The model provides species-specific pollen potential maps for each day of the simulation period; these are then used by a pollen transport model to simulate ambient pollen concentrations as described in a companion paper (Zhang et al., 2013a, which also presents model evaluation results for the S. CA model domain. The STaMPS model was also used to quantify the possible impact of climate change on pollen season under the IPCC SRES A1B scenario as simulated by the ECHAM5 global climate model. Current (1995–2004 and future (2045–2054

  5. Computational Aeroacoustic Analysis System Development

    Science.gov (United States)

    Hadid, A.; Lin, W.; Ascoli, E.; Barson, S.; Sindir, M.

    2001-01-01

    Many industrial and commercial products operate in a dynamic flow environment and the aerodynamically generated noise has become a very important factor in the design of these products. In light of the importance in characterizing this dynamic environment, Rocketdyne has initiated a multiyear effort to develop an advanced general-purpose Computational Aeroacoustic Analysis System (CAAS) to address these issues. This system will provide a high fidelity predictive capability for aeroacoustic design and analysis. The numerical platform is able to provide high temporal and spatial accuracy that is required for aeroacoustic calculations through the development of a high order spectral element numerical algorithm. The analysis system is integrated with well-established CAE tools, such as a graphical user interface (GUI) through PATRAN, to provide cost-effective access to all of the necessary tools. These include preprocessing (geometry import, grid generation and boundary condition specification), code set up (problem specification, user parameter definition, etc.), and postprocessing. The purpose of the present paper is to assess the feasibility of such a system and to demonstrate the efficiency and accuracy of the numerical algorithm through numerical examples. Computations of vortex shedding noise were carried out in the context of a two-dimensional low Mach number turbulent flow past a square cylinder. The computational aeroacoustic approach that is used in CAAS relies on coupling a base flow solver to the acoustic solver throughout a computational cycle. The unsteady fluid motion, which is responsible for both the generation and propagation of acoustic waves, is calculated using a high order flow solver. The results of the flow field are then passed to the acoustic solver through an interpolator to map the field values into the acoustic grid. The acoustic field, which is governed by the linearized Euler equations, is then calculated using the flow results computed

  6. Massively parallel sequencing of short tandem repeats-Population data and mixture analysis results for the PowerSeq™ system.

    Science.gov (United States)

    van der Gaag, Kristiaan J; de Leeuw, Rick H; Hoogenboom, Jerry; Patel, Jaynish; Storts, Douglas R; Laros, Jeroen F J; de Knijff, Peter

    2016-09-01

    Current forensic DNA analysis predominantly involves identification of human donors by analysis of short tandem repeats (STRs) using Capillary Electrophoresis (CE). Recent developments in Massively Parallel Sequencing (MPS) technologies offer new possibilities in analysis of STRs since they might overcome some of the limitations of CE analysis. In this study 17 STRs and Amelogenin were sequenced in high coverage using a prototype version of the Promega PowerSeq™ system for 297 population samples from the Netherlands, Nepal, Bhutan and Central African Pygmies. In addition, 45 two-person mixtures with different minor contributions down to 1% were analysed to investigate the performance of this system for mixed samples. Regarding fragment length, complete concordance between the MPS and CE-based data was found, marking the reliability of MPS PowerSeq™ system. As expected, MPS presented a broader allele range and higher power of discrimination and exclusion rate. The high coverage sequencing data were used to determine stutter characteristics for all loci and stutter ratios were compared to CE data. The separation of alleles with the same length but exhibiting different stutter ratios lowers the overall variation in stutter ratio and helps in differentiation of stutters from genuine alleles in mixed samples. All alleles of the minor contributors were detected in the sequence reads even for the 1% contributions, but analysis of mixtures below 5% without prior information of the mixture ratio is complicated by PCR and sequencing artefacts. PMID:27347657

  7. Computer aided training system development

    International Nuclear Information System (INIS)

    The first three phases of Training System Development (TSD) -- job and task analysis, curriculum design, and training material development -- are time consuming and labor intensive. The use of personal computers with a combination of commercial and custom-designed software resulted in a significant reduction in the man-hours required to complete these phases for a Health Physics Technician Training Program at a nuclear power station. This paper reports that each step in the training program project involved the use of personal computers: job survey data were compiled with a statistical package, task analysis was performed with custom software designed to interface with a commercial database management program. Job Performance Measures (tests) were generated by a custom program from data in the task analysis database, and training materials were drafted, edited, and produced using commercial word processing software

  8. A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B.

    Science.gov (United States)

    Nijenhuis, Wilco; von Castelmur, Eleonore; Littler, Dene; De Marco, Valeria; Tromer, Eelco; Vleugel, Mathijs; van Osch, Maria H J; Snel, Berend; Perrakis, Anastassis; Kops, Geert J P L

    2013-04-15

    The mitotic checkpoint ensures correct chromosome segregation by delaying cell cycle progression until all kinetochores have attached to the mitotic spindle. In this paper, we show that the mitotic checkpoint kinase MPS1 contains an N-terminal localization module, organized in an N-terminal extension (NTE) and a tetratricopeptide repeat (TPR) domain, for which we have determined the crystal structure. Although the module was necessary for kinetochore localization of MPS1 and essential for the mitotic checkpoint, the predominant kinetochore binding activity resided within the NTE. MPS1 localization further required HEC1 and Aurora B activity. We show that MPS1 localization to kinetochores depended on the calponin homology domain of HEC1 but not on Aurora B-dependent phosphorylation of the HEC1 tail. Rather, the TPR domain was the critical mediator of Aurora B control over MPS1 localization, as its deletion rendered MPS1 localization insensitive to Aurora B inhibition. These data are consistent with a model in which Aurora B activity relieves a TPR-dependent inhibitory constraint on MPS1 localization.

  9. Magnetic properties and specific heat of MPS3 (M=Mn, Fe, Zn)

    International Nuclear Information System (INIS)

    The magnetic properties and specific heat of MPS3 (M=Mn, Fe and Zn) have been investigated. While ZnPS3 is non-magnetic, MnPS3 and FePS3 are antiferromagnets with the Neel temperature TN of 78 and 118 K, respectively. Nevertheless, the specific heat of MnPS3 and FePS3 is smaller than that of ZnPS3 below about 20 K. The temperature dependence of the magnetic specific heat CM of MnPS3 shows a broad hump which is characteristic to the two dimensional magnetic materials and a small sharp peak at TN. On the other hand, that of FePS3 shows a large sharp peak at TN. As for FePS3, the temperature dependences of the magnetization M and CM are well reproduced by taking account of the magneto-elastic effect which introduces an additional term proportional to the square of the average value of the spin to the exchange coupling constant. As for MnPS3, marked two dimensional characters appear in the temperature dependence of M and CM. The observed TN is much smaller than the paramagnetic Curie temperature of 240 K obtained from the temperature dependence of the magnetic susceptibility at high temperature

  10. Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line.

    Science.gov (United States)

    Borjigin, Liushiqi; Shimazu, Tomoyuki; Katayama, Yuki; Watanabe, Kouichi; Kitazawa, Haruki; Roh, Sang-Gun; Aso, Hisashi; Katoh, Kazuo; Uchida, Takafumi; Suda, Yoshihito; Sakuma, Akiko; Nakajo, Mituru; Suzuki, Keiichi

    2016-08-01

    To understand the influence of crossbreeding on Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics, two crossbred lines were characterized. One crossbred line, LaWa, was generated by crossing the MPS pulmonary lesion selected Landrace line (La) and the highly immune-selected Large White line (Wa). The second crossbred line, LaWb, was generated by crossing the La line and the nonselected Large White line (Wb). The crossbred LbWb line (nonselected Landrace line × nonselected Large White line) and the La line were used as controls. The LaWa and LaWb lines had an intermediate level of MPS lung lesions between La and LbWb lines, although the difference was not statistically significant. After stimulation with sheep red blood cells (SRBCs), the LaWb and LaWa lines showed immune characteristics similar to that of the La line; the number of monocytes in peripheral blood increased, while B cells, T cells, secretion of SRBC-specific immunoglobulin G, and interleukin (IL)-13 decreased. Additionally, the number of natural killer (NK) cells and the expression of IL-4 and IL-17 were significantly higher in the LaWb and LaWa lines, respectively. These data suggested that crossbreeding of La and Wa lines resulted in the inheritance of some of the selected immune responses. PMID:26709243

  11. Common N-acetylgalactosamine-6-sulfate sulfatase (GALNS exon mutations in Brazilian patients with mucopolysaccharidosis IVA (MPS IVA

    Directory of Open Access Journals (Sweden)

    Tatiana Dieter

    2007-01-01

    Full Text Available Morquio A Syndrome (mucopolysaccharidosis IVA - MPS IVA, OMIM# 253000 is an autosomal recessive inborn error of metabolism caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS. We investigated five unrelated Brazilian MPS IVA families for mutations in exons 4, 5, 9 and 10 of the GALNS gene. Six out of the 10 mutant alleles were identified. Taken together with a previous study, which included six unrelated families, common mutations among Brazilian patients were p.N164T, p.G116S and p.G301C. Among one hundred control subjects three novel silent mutations were found (p.A107A; GCC -> GCT, p.Y108Y; TAC -> TAT, p.P357P; CCG -> CCA. Screening starting with exons 4, 5, 9, 10 and 11 may be a good strategy for genotyping of Brazilian patients since these exons include 73% of all mutations identified in the current and previous studies.

  12. Growth of MPS-capped ZnS quantum dots in self-assembled thin films: Influence of heat treatment

    Science.gov (United States)

    Koç, Kenan; Tepehan, Fatma Zehra; Tepehan, Galip Gültekin

    2015-12-01

    The colloidal ZnS quantum dots (QDs) were prepared using 3-mercaptopropyltrimethoxysilane (MPS) molecules. Sol-gel spin coating method was used to deposit the colloidal nanoparticles on a glass substrate. Several features of the MPS were made use to produce self assembled thin films of ZnS quantum dots in a SiO2 network. Produced films were heat treated in between 225 °C and 325 °C to investigate their growth kinetics. The result showed that their size changed approximately from 3 nm to 4 nm and the first excitation peak position changed from 4.6 eV to 4.1 eV in this temperature interval. The activation energy of the nanoparticles for the Ostwald ripening process was found to be 59 kJ/mol.

  13. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase.

    Science.gov (United States)

    Colombo, Riccardo; Caldarelli, Marina; Mennecozzi, Milena; Giorgini, Maria Laura; Sola, Francesco; Cappella, Paolo; Perrera, Claudia; Depaolini, Stefania Re; Rusconi, Luisa; Cucchi, Ulisse; Avanzi, Nilla; Bertrand, Jay Aaron; Bossi, Roberto Tiberio; Pesenti, Enrico; Galvani, Arturo; Isacchi, Antonella; Colotta, Francesco; Donati, Daniele; Moll, Jürgen

    2010-12-15

    MPS1 kinase is a key regulator of the spindle assembly checkpoint (SAC), a mitotic mechanism specifically required for proper chromosomal alignment and segregation. It has been found aberrantly overexpressed in a wide range of human tumors and is necessary for tumoral cell proliferation. Here we report the identification and characterization of NMS-P715, a selective and orally bioavailable MPS1 small-molecule inhibitor, which selectively reduces cancer cell proliferation, leaving normal cells almost unaffected. NMS-P715 accelerates mitosis and affects kinetochore components localization causing massive aneuploidy and cell death in a variety of tumoral cell lines and inhibits tumor growth in preclinical cancer models. Inhibiting the SAC could represent a promising new approach to selectively target cancer cells.

  14. Design, Calibration, and Expected On-Orbit Performance of the GOES-R MPS-LO Suprathermal Plasma Analyzer Instrument

    Science.gov (United States)

    Golightly, M. J.; McGarity, J. O.; Dichter, B. K.; Galica, G. E.

    2015-12-01

    The next generation U.S. geosynchronous weather satellite—GOES series R-U—will include for the first time a suprathermal plasma analyzer. The Magnetospheric Particle Sensor-Low (MPS-LO), an electrostatic analyzer utilizing triquadrispheric geometry (270° turn)deflection electrodes, will measure the flux of electrons and ions with energies between 30 eV - 30 keV in fifteen logarithmically-spaced differential energy channels and arrival direction in twelve angular bins. MPS-LO consists of two sensor heads mounted in a common electronics box. Each sensor head contains a set of deflection electrodes, microchannel plates, and segmented detector anodes. The common electronics box provides the power and I/O interface with a data processing unit, voltage supplies for all of the instrument's electronics, high voltage for the deflection electrodes, in-flight calibration pulsers, and the digital electronics to process signals from sensor heads' detector anodes. Great care was taken in the manufacture and mounting of the triquadrisphere deflection electrodes; each electrode was machined from a single piece of aluminum and specific electrode combinations were mounted with precision machined spacers and matched drilling. The precise fabrication and assembly resulted in near perfect spherical electric fields between the electrodes. The triquadrispheric electrode shape also prevents photons from reaching the detection elements-as a result, MPS-LO is solar blind. The combined field-of-view for the two sensor heads is 180° x 5°, with the larger angle in a plane perpendicular to the spacecraft's orbit and its central axis oriented anti-Earthward. An incident particle's arrival direction is determined in one of twelve 15° x 5° angular zones. A set of shielded anodes is used to measure the background caused by penetrating charged particles that reach the MCPs; this background data is used to correct the MPS-LO data. The instrument's energy resolution ΔE/E is 5.8%.

  15. MPS Eesti juht Pasi Harttunen : heaks spetsialistiks saab vaid alumiselt astmelt alustades / Pasi Harttunen ; interv. Tiina Saar

    Index Scriptorium Estoniae

    Harttunen, Pasi, 1971-

    2008-01-01

    Personalifirma MPS Eesti juht vastab küsimustele, mis puudutavad Eesti tööandjaid, kellel pole raskusi spetsialistide leidmisel, hea või halva tööandja mainega ettevõtteid, võtmetöötajate suurt liikuvust, spetsialistide motiveerimist ja nende usaldamist, kõige enam spetsialistide puuduse käes vaevlevaid valdkondi ning haridussüsteemi taset spetsialistide koolitamisel. Vt. samas: Kersti Valter. Spetsialistide palgaootused rahunenud; Karin Press. Napib kriisidega toime tulnud spetsialiste

  16. Development of Dendritic Cell System

    Institute of Scientific and Technical Information of China (English)

    Li Wu; Aleksandar Dakic

    2004-01-01

    The dendritic cell system contains conventional dendritic cells (DCs) and plasmacytoid pre-dendritic cells (pDCs). Both DCs and pDCs are bone marrow derived cells. Although the common functions of DCs are antigen-processing and T-lymphocyte activation, they differ in surface markers, migratory patterns, and cytokine output. These differences can determine the fate of the T cells they activate. Several subsets of mature DCs have been described in both mouse and human and the developmental processes of these specialized DC subsets have been studied extensively. The original concept that all DCs were of myeloid origin was questioned by several recent studies, which demonstrated that in addition to the DCs derived from myeloid precursors,some DCs could also be efficiently generated from lymphoid-restricted precursors. Moreover, it has been shown recently that both conventional DCs and pDCs can be generated by the Flt3 expressing hemopoietic progenitors regardless of their myeloid- or lymphoid-origin. These findings suggest an early developmental flexibility of precursors for DCs and pDCs. This review summarizes some recent observations on the development of DC system in both human and mouse.

  17. Development of Dendritic Cell System

    Institute of Scientific and Technical Information of China (English)

    LiWu; AleksandarDakic

    2004-01-01

    The dendritic cell system contains conventional dendritic cells (DCs) and plasmacytoid pre-dendritic cells (pDCs). Both DCs and pDCs are bone marrow derived calls. Although the common functions of DCs are antigen-processing and T-lymphocyte activation, they differ in surface markers, migratory patterns, and cytokine output. These differences can determine the fate of the T cells they activate. Several subsets of mature DCs have been described in both mouse and human and the developmental processes of these specialized DC subsets have been studied extensively. The original concept that all DCs were of myeloid origin was questioned by several recent studies, which demonstrated that in addition to the DCs derived from myeloid precursors, some DCs could also be efficiently generated from lymphoid-restricted precursors. Moreover, it has been shown recently that both conventional DCs and pDCs can be generated by the Fit3 expressing hemopoietic progenitors regardless of their myeloid- or lymphoid-origin. These findings suggest an early developmental flexibility of precursors for DCs and pDCs. This review summarizes some recent observations on the development of DC system in both human and mouse. Cellular & Molecular Immunology. 2004;1(2):112-118.

  18. Developing a Carbon Observing System

    Science.gov (United States)

    Moore, B., III

    2015-12-01

    There is a clear need to better understand and predict future climate change, so that science can more confidently inform climate policy, including adaptation planning and future mitigation strategies. Understanding carbon cycle feedbacks, and the relationship between emissions (fossil and land use) and the resulting atmospheric carbon dioxide (CO2) and methane (CH4) concentrations in a changing climate has been recognized as an important goal by the IPCC. The existing surface greenhouse gas observing networks provide accurate and precise measurements of background values, but they are not configured to target the extended, complex and dynamic regions of the carbon budget. Space Agencies around the globe are committed to CO2 and CH4 observations: GOSAT-1/2, OCO-2/3, MERLin, TanSat, and CarbonSat. In addition to these Low Earth Orbit (LEO) missions, a new mission in Geostationary Orbit (GEO), geoCARB, which would provide mapping-like measurements of carbon dioxide, methane, and carbon monoxide concentrations over major land areas, has been recently proposed to the NASA Venture Program. These pioneering missions do not provide the spatial/temporal coverage to answer the key carbon-climate questions at process relevant scales nor do they address the distribution and quantification of anthropogenic sources at urban scales. They do demonstrate, however, that a well-planned future system of system integrating space-based LEO and GEO missions with extensive in situ observations could provide the accuracy, spatial resolution, and coverage needed to address critical open issues in the carbon-climate system. Dr. Diana Wickland devoted enormous energy in developing a comprehensive apprioach to understand the global carbon cycle; she understood well that an integrated, coordinated, international approach is needed. This shines through in her recent contribution in co-chairing the team that produced the "CEOS Strategy for Carbon Observations from Space." A NASA-funded community

  19. Project management for information system development

    OpenAIRE

    Zhang, Yang

    2011-01-01

    Nowadays, with the development of the information and communication technology, information systems have been developing rapidly. More and more software companies choose to develop the information system to be their main business. They want to increase their business profits by developing the information system. However, the failure rate of developing information system has been high during these years. The purpose of the thesis is to discover how to use project management knowledge to improv...

  20. Systems biology study of mucopolysaccharidosis using a human metabolic reconstruction network.

    Science.gov (United States)

    Salazar, Diego A; Rodríguez-López, Alexander; Herreño, Angélica; Barbosa, Hector; Herrera, Juliana; Ardila, Andrea; Barreto, George E; González, Janneth; Alméciga-Díaz, Carlos J

    2016-02-01

    Mucopolysaccharidosis (MPS) is a group of lysosomal storage diseases (LSD), characterized by the deficiency of a lysosomal enzyme responsible for the degradation of glycosaminoglycans (GAG). This deficiency leads to the lysosomal accumulation of partially degraded GAG. Nevertheless, deficiency of a single lysosomal enzyme has been associated with impairment in other cell mechanism, such as apoptosis and redox balance. Although GAG analysis represents the main biomarker for MPS diagnosis, it has several limitations that can lead to a misdiagnosis, whereby the identification of new biomarkers represents an important issue for MPS. In this study, we used a system biology approach, through the use of a genome-scale human metabolic reconstruction to understand the effect of metabolism alterations in cell homeostasis and to identify potential new biomarkers in MPS. In-silico MPS models were generated by silencing of MPS-related enzymes, and were analyzed through a flux balance and variability analysis. We found that MPS models used approximately 2286 reactions to satisfy the objective function. Impaired reactions were mainly involved in cellular respiration, mitochondrial process, amino acid and lipid metabolism, and ion exchange. Metabolic changes were similar for MPS I and II, and MPS III A to C; while the remaining MPS showed unique metabolic profiles. Eight and thirteen potential high-confidence biomarkers were identified for MPS IVB and VII, respectively, which were associated with the secondary pathologic process of LSD. In vivo evaluation of predicted intermediate confidence biomarkers (β-hexosaminidase and β-glucoronidase) for MPS IVA and VI correlated with the in-silico prediction. These results show the potential of a computational human metabolic reconstruction to understand the molecular mechanisms this group of diseases, which can be used to identify new biomarkers for MPS. PMID:26276570

  1. Therapeutic Efficacy of Bone Marrow Transplant, Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB

    OpenAIRE

    Heldermon, Coy D.; Ohlemiller, Kevin K.; Herzog, Erik D.; Vogler, Carole; Qin, Elizabeth; Wozniak, David F.; Tan, Yun; John L Orrock; Sands, Mark S.

    2010-01-01

    Sanfilippo syndrome type B (MPS IIIB) is a lysosomal storage disease resulting from a deficiency of N-acetyl-glucosaminidase (NAGLU) activity. In an attempt to correct the disease in the murine model of MPS IIIB, neonatal mice were treated with intracranial AAV2/5-NAGLU (AAV), syngeneic bone marrow transplant (BMT), or both (AAV/BMT). All treatments resulted in some improvement in clinical phenotype. Adeno-associated viral (AAV) treatment resulted in improvements in lifespan, motor function, ...

  2. Sample preparation of membrane proteins suitable for solid-state MAS NMR and development of assignment strategies

    OpenAIRE

    Hiller, Matthias

    2009-01-01

    Although the basic structure of biological membranes is provided by the lipid bilayer, most of the specific functions are carried out by membrane proteins (MPs) such as channels, ion-pumps and receptors. Additionally, it is known, that mutations in MPs are directly or indirectly involved in many diseases. Thus, structure determination of MPs is of major interest not only in structural biology but also in pharmacology, especially for drug development. Advances in structural biology of membrane...

  3. APPROACHING DEVELOPMENT IN LOGISTIC INFORMATION SYSTEMS

    Directory of Open Access Journals (Sweden)

    Louis F Buys

    2012-01-01

    Full Text Available The introduction of technology into modern defence necessitates integrated computerized information systems to render effective and efficient logistic support. Traditional information system development does not ensure attainment of use and time scale requirements in the continuously developing environment of logistics. This paper describes current approaches to the development of logistic information systems.

  4. Restructure Staff Development for Systemic Change

    Science.gov (United States)

    Kelly, Thomas F.

    2012-01-01

    This paper presents a systems approach based on the work of W. Edwards Deming to system wide, high impact staff development. Deming has pointed out the significance of structure in systems. By restructuring the process of staff development we can bring about cost effective improvement of the whole system. We can improve student achievement while…

  5. MEASUREMENT PROCESS OF SOFTWARE DEVELOPMENT PROJECTS FOR SUPPORTING STRATEGIC BUSINESS OBJECTIVES IN SOFTWARE DEVELOPING COMPANIES

    Directory of Open Access Journals (Sweden)

    Sandra Lais Pedroso

    2013-08-01

    Full Text Available Software developing companies work in a competitive market and are often challenged to make business decisions with impact on competitiveness. Models accessing maturity for software development processes quality, such as CMMI and MPS-BR, comprise process measurements systems (PMS. However, these models are not necessarily suitable to support business decisions, neither to achieve strategic goals. The objective of this work is to analyze how the PMS of software development projects could support business strategies for software developing companies. Results taken from this work show that PMS results from maturity models for software processes can be suited to help evaluating operating capabilities and supporting strategic business decisions.

  6. Product/Service-System Development

    DEFF Research Database (Denmark)

    Tan, Adrian; McAloone, Timothy Charles; Gall, Catherine

    2007-01-01

    that continuously deliver value and create a strong competitive advantage. PSS attempts to transcend the old industrial credo that value is embedded in products and the consideration of ‘cost-quality-time’ relates to the physical artefact. While there is increasing interest in PSS, limited research has been done...... in the design and development aspects of PSS. The objective of this paper is to explore how a global manufacturing company is developing an offering to their customers that is focused on the utility of their products throughout their life time. The paper describes the process of how a company is shifting from...... of their products. This process of re-defining the value of what the company is actually offering to its customers is seen as a key element in PSS development. PSS development is expected to expand conventional product development in new directions, such as new activities, roles and responsibilities, knowledge...

  7. Flexible Developing System for Modern Instrument Manufacturing

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The modern instrument manufacturing has many features, such as high technologies, multiple varieties and small quantities. Aiming at those features, an instrumentation flexible developing system (IFDS) is presented. It constitutes a kind of opening, compatible, extensible and upgradeable flexible developing system, and it will offer a kind of technology equipment for the research and development of new modern instrument products. Its flexible mechanism is able to be suited for different and special requirements of many instrument systems, and its system integrated mechanism is able to adapt to common technological features of most instrument systems. It is IFDS that makes it easy to accomplish a quick system integration of instrument products. IFDS solves key technological problems related to modern instruments development, develops multiple systems for modern instrument development and accomplishes rapid development of series of new products.

  8. Usability Factors in Information Systems Development

    OpenAIRE

    K. Chandra Sekharaiah; A. Radha Krishna

    2014-01-01

    Computers have become a commonplace technology for today’s man. Computer users demand more reliable and durable interfaces from information processing applications developers. Information systems (ISs) research and development, over the years, has been steady so well that the arena has now grown into various subfields such as Cognitive Information Systems (CISs), Web Information Systems(WISs), Geographical Information Systems(GISs), Enterprise Information Systems (EISs), and so...

  9. A View of Earth System Model Development

    Institute of Scientific and Technical Information of China (English)

    ZHOU Tianjun; YU Yongqiang; WANG Bin

    2009-01-01

    This paper gives a definition of earth system model and shows three development phases of it, including physical climate system model, earth climate system model, and earth system model, based on an inves-tigation of climate system models in the world. It provides an expatiation on the strategic significance of future development of earth system model, an introduction of some representative scientific research plans on development of earth system model home and abroad, and a review of its status and trends based on the models of the fourth assessment report (AR4) of the Intergovernmental Panel on Climate Change (IPCC).Some suggestions on future development of earth system model in China are given, which are expected to be helpful to advance the development.

  10. Model Driven Development of Data Sensitive Systems

    DEFF Research Database (Denmark)

    Olsen, Petur

    2014-01-01

    Model-driven development strives to use formal artifacts during the development process. Formal artifacts enables automatic analyses of some aspects of the system under development. This serves to increase the understanding of the (intended) behavior of the system as well as increasing error...... to the values of variables. This theses strives to improve model-driven development of such data-sensitive systems. This is done by addressing three research questions. In the first we combine state-based modeling and abstract interpretation, in order to ease modeling of data-sensitive systems, while allowing...... efficient model-checking and model-based testing. In the second we develop automatic abstraction learning used together with model learning, in order to allow fully automatic learning of data-sensitive systems to allow learning of larger systems. In the third we develop an approach for modeling and model...

  11. Developing multiagent systems: the Gaia Methodology

    OpenAIRE

    Zambonelli, F.; Jennings, N.R.; Wooldridge, M.

    2003-01-01

    Systems composed of interacting autonomous agents offer a promising software engineering approach for developing applications in complex domains. However, this multiagent system paradigm introduces a number of new abstractions and design/development issues when compared with more traditional approaches to software development. Accordingly, new analysis and design methodologies, as well as new tools, are needed to effectively engineer such systems. Against this background, the contribution of ...

  12. Character and Analyse of the MPS%混合PIN/Schottky二极管特性简析

    Institute of Scientific and Technical Information of China (English)

    蔡震; 马洪江

    2012-01-01

    软恢复快速功率二极管广泛应用于电力电子电路中,采用MPS结构的软恢复快速二极管既克服了传统PIN二极管开关速度较低的缺点,又解决了肖特基二极管较低击穿电压的缺陷,它具有速度快、击穿电压高、漏电流小、软恢复特性好的优点.对MPS二极管的各个参数进行研究,引出MPS二极管在应用时的相对优势、进而阐述它的结构特点、工作原理和相关特性.%Fast and soft recovery switching power diodea are widely used in electronic circuits, the MI'S structure of soft recovery diode that is not only quickly overcome the shortcomings of traditional PIN diode' s switching corresponding lower speed, but also solved the defects of low breakdown voltage existing in Schottky diodes, It has such good advantages as fast, high breakdown voltages, low leakage currents, and soft recovery characteristics, the research of various parameters of MPS diode are done on the subject , and then leads to the comparative advantages of MPS diodes in the application, further elaborated its structural characteristics, principle and relevant features.

  13. Investigation of current transport parameters of Ti/4H-SiC MPS diode with inhomogeneous barrier

    Institute of Scientific and Technical Information of China (English)

    Song Qing-Wen; Zhang Yu-Ming; Zhang Yi-Men; Chen Feng-Ping; Tang xiao-Yan

    2011-01-01

    The current transport parameters of 4H-SiC merged PiN Schottky (MPS) diode are investigated in a temperature range of 300-520 K. Evaluation of the experimental current-voltage (Ⅰ-Ⅴ) data reveals the decrease in Schottky barrier height φb but an increase in ideality factor n, with temperature decreasing, which suggests the presence of an inhomogeneous Schottky barrier. The current transport behaviours are analysed in detail using the Tung's model and the effective area of the low barrier patches is extracted. It is found that small low barrier patches, making only 4.3% of the total contact, may significantly influence the device electrical characteristics due to the fact that a barrier height of 0.968 eV is much lower than the average barrier height 1.39 eV. This shows that ion implantation in the Schottky contact region of MPS structure may result in a poor Ti/4H-SiC interface quality. In addition, the temperature dependence of the specific on-resistance (Ron-sp), T2.14, is determined between 300 K and 520 K, which is similar to that predicted by a reduction in electron mobility.

  14. Highly reusability surface loaded metal particles magnetic catalyst microspheres (MCM-MPs) for treatment of dye-contaminated water

    Science.gov (United States)

    Liu, Ying; Zhang, Kun; Yin, Xiaoshuang; Yang, Wenzhong; Zhu, Hongjun

    2016-04-01

    The metal-deposited magnetic catalyst microspheres (MCM-MPs) were successfully synthesized by one facile, high yield and controllable approach. Here, the bare magnetic microspheres were firstly synthesized according to the solvothermal method. Then silica shell were coated on the surface of the magnetic microspheres via sol-gel method, and subsequently with surface modifying with amino in the purpose to form SiO2-NH2 shell. Thus, metal particles were easily adsorbed into the SiO2-NH2 shell and in-situ reduced by NaBH4 solution. All the obtained products (MCM-Cu, MCM-Ag, MCM-Pd) which were monodisperse and constitutionally stable were exhibited high magnetization and excellent catalytic activity towards dyes solution reduction. The catalytic rate ratio of MCM-Pd: MCM-Cu: MCM-Ag could be 10:3:1. Besides, some special coordination compound Cu2(OH)3Br had been generated in the in-situ reduced process of MCM-Cu, which produced superior cyclical stability (>20 times) than that of MCM-Ag and MCM-Pd. In all, those highly reusability and great catalytic efficiency of MCM-MPs show promising and great potential for treatment of dye-contaminated water.

  15. Clinical Analysis about Diagnosis and Treatment of 86 Hand Paresthesia Cases Using MPS Theory and Pharmacopuncture Therapy

    Directory of Open Access Journals (Sweden)

    Sung-Won Oh

    2007-12-01

    Full Text Available Objectives : Hand paresthesia is common syndrome and the cause is more unknown than known reason. The Purpose of this study were investigated the effects of Myofacial Pain Syndrome theory to make diagnosis and treatment by Pharmacopuncture for the patients of hand paresthesia. Method : This study was carried out to established the clinical criteria of hand parethesia. The patients who had past history of diabeics, neuropathy induced by alcohol or drug were excluded, and 86 patients who had hand paresthesia related with unknown-reason was selected by the interview process. And the effects of Pharmacopuncture theory were analyzed using VAS score before and after treatment. Results and conclusions : 56.9% of unknown-reason patients are positive at diagnosis by MPS theory. While positive group decrease from 62.81±14.27 to 25.28±15.97, negative group decrease from 55.88±10.92 to 48.28±14.01 by VAS scores. Positive group was accordingly more effective than negative group. So diagnosis and treatment for hand numbness patients by MPS theory was useful in clinical.

  16. Mobile Application Development: Component Retrieval System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed technology development concept is a software application tool developed for use on a mobile device at SSC for use in the component retrieval system...

  17. Autonomous Systems Developments and Trends

    CERN Document Server

    Kyamaky, Kyandoghere; Kacprzyk, Janusz

    2012-01-01

    The Workshops on Autonomous Systems emanated from a gathering with the doctoral students of just three chairs at Fernuniversität in Hagen, which we organise twice per year for a number of years now. Their purpose is to discuss on-going research and to create a community spirit. Furthermore, they serve as a means of structuring the students' research processes. The workshop has grown and matured in several respects. The doctoral students presenting their work do not come from a single university anymore, but from three. Besides them and their supervisors, also other scientists became interested in the event and contribute to its programme. Following the model of Advanced Study Institutes, they are available on the premises for relaxed, informal discussions outside the formal sessions. Finally, with the co-sponsorship of Gesellschaft für Informatik, the German Computer Society, and this surprisingly comprehensive volume of contributions published by Springer-Verlag the workshop turned into a visible scientifi...

  18. Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations

    Science.gov (United States)

    Mobarrez, Fariborz; Vikerfors, Anna; Gustafsson, Johanna T.; Gunnarsson, Iva; Zickert, Agneta; Larsson, Anders; Pisetsky, David S.; Wallén, Håkan; Svenungsson, Elisabet

    2016-01-01

    Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by circulating autoantibodies and the formation of immune complexes. In these responses, the selecting self-antigens likely derive from the remains of dead and dying cells, as well as from disturbances in clearance. During cell death/activation, microparticles (MPs) can be released to the circulation. Previous MP studies in SLE have been limited in size and differ regarding numbers and phenotypes. Therefore, to characterize MPs more completely, we investigated 280 SLE patients and 280 individually matched controls. MPs were measured with flow cytometry and phenotyped according to phosphatidylserine expression (PS+/PS−), cellular origin and inflammatory markers. MPs, regardless of phenotype, are 2–10 times more abundant in SLE blood compared to controls. PS− MPs predominated in SLE, but not in controls (66% vs. 42%). Selectively in SLE, PS− MPs were more numerous in females and smokers. MP numbers decreased with declining renal function, but no clear association with disease activity was observed. The striking abundance of MPs, especially PS− MPs, suggests a generalized disturbance in SLE. MPs may be regarded as “liquid biopsies” to assess the production and clearance of dead, dying and activated cells, i.e. pivotal events for SLE pathogenesis. PMID:27777414

  19. Toward a Cooperative Experimental System Development Approach

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Kyng, Morten; Mogensen, Preben Holst

    1997-01-01

    , however, not limited to this development context, it may be applied for in-house or contract development as well. In system development, particularly in cooperative and experimental system development, we argue that it is necessary to analytically separate the abstract concerns, e.g. analysis, design......This chapter represents a step towards the establishment of a new system development approach, called Cooperative Experimental System Development (CESD). CESD seeks to overcome a number of limitations in existing approaches: specification oriented methods usually assume that system design can...... be based solely on observation and detached reflection; prototyping methods often have a narrow focus on the technical construction of various kinds of prototypes; Participatory Design techniques—including the Scandinavian Cooperative Design (CD) approaches—seldom go beyond the early analysis...

  20. Safeguards -Safeguards system development support-

    International Nuclear Information System (INIS)

    This project mainly focused to technically support national safeguards inspection which is scheduled in the beginning of 1997. It includes non-destructive assay of nuclear fuels, analysis on inspection and environmental samples, remote monitoring of nuclear activities and its analysis, survey on remote sensing of satellite for safeguards application. Non-destructive assay of nuclear fuels dealt with development on verification of spent fuels with emphasis to fabrication of inspection tools with surveillance and gamma measurement on CANDU spent fuels. For sample analysis, study was carried out on process inspection sample analysis method. In addition to this, ultra low background laboratory was set up to execute environmental and swipe samples and sample treatment techniques including water, soil, plant, et al. were researched. Tritiums which were sampled around power plants were analysed. With cooperation of Satellite Technology Research Center of KAIST, use of civilian satellite imagery was surveyed. To train facility operators for safeguards, various technology on non-destructive assay was lectured to personnel of Korea Electric Power Corporation. And to enhance out capabilities, non-destructive assay training was done at Los Alamos National Lab. of U.S. through the agreement of MOST and DOE agreement, and information on DA technology was exchanged at Nuclear Material Control Center of Japan. (author). 22 tabs., 52 figs., 53 refs

  1. A Social Ontology for Information System Development

    OpenAIRE

    Kolp, Manuel; Giorgini, Palolo

    2002-01-01

    Organizations are changing at an ever-faster pace, as they try to keep up with globalization and the information revolution. Unfortunately, information systems technologies do not support system evolution well, making information systems a roadblock to i* organizational change. We propose to view information systems as social structures and define methodologies which develop and evolve seamlessly an information system within its operational environment. To this end, this paper proposes an ont...

  2. The development of accelerator mass spectroscopy system

    Energy Technology Data Exchange (ETDEWEB)

    Mitarai, Shiro; Machida, Atsushi; Iwata, Yasunao; Tsubusaki, Yoshihiro; Tanaka, Katsuhiko; Maeda, Toyokazu; Nakajima, Takao [Kyushu Univ., Fukuoka (Japan)

    2001-02-01

    Inverse PIXE method was applied to the differentiation of Chlorine 36 and Sulfur 36. The contaminated soil from the USSR nuclear test site was measured. Terminal potential of the tandem accelerator was controlled by GVM. A new AMS system, using time-of flight method is under development. The development of beam buncher and beam chopper for the system is briefly described. (A. Yamamoto)

  3. Notes on innovation systems and economic development

    DEFF Research Database (Denmark)

    Lundvall, Bengt-Åke

    2011-01-01

    This paper gives a brief history and background for the concept 'national innovation system' and discusses its usefulness for understanding and managing economic development.......This paper gives a brief history and background for the concept 'national innovation system' and discusses its usefulness for understanding and managing economic development....

  4. Space Shuttle Main Propulsion System Gaseous Hydrogen Flow Control Valve Poppet Failure

    Science.gov (United States)

    Zeitler, Rick

    2010-01-01

    The presentation provides background information pertinent to the MPS GH2 Flow Control Valve Poppet failure which occurred on the Space Shuttle Endeavour during STS-126 flight. The presentation provides general MPS system operating information which is pertinent to understanding the failure causes and affects. The presentation provides additional background information on the operating environment in which the FCV functions and basic design history of the flow control valve. The presentation provides an overview of the possible flight failure modes and a brief summary of the flight rationale which was developed for this failure event. This presentation is an introductory presentation to 3 other speakers at the conference who will be speaking on M&P aspects of the investigation, non destructive inspection techniques development, and particle impact testing.

  5. Factors Affecting the Adoption of Mobile Payment Systems: An Empirical Analysis

    Directory of Open Access Journals (Sweden)

    İkram Daştan

    2016-02-01

    Full Text Available The world witnessed a rapid growth in the e-commerce in the recent years. Widespread use of mobile devices in the e-commerce has a role in this augmentation. Associated with growth of trading volume and the introduction of new devices, new products and solutions emerge and they diversify concerning online payments. Consumer attitudes and behaviors may change according to these developments. The purpose of this study is to investigate the factors effecting adoption of mobile payment systems by the consumer. 225 individuals were surveyed online through convenience sampling method. A research model was developed and proposed relationships were tested using structural equation modeling. The empirical findings point out that perceived trust, perceived mobility and attitudes positively affect the adoption of MPS; perceived usefulness and perceived ease of use have no effect on adoption of MPS. Furthermore perceived reputation positively related to perceived trust and finally environmental risk negatively related to perceived trust.

  6. Solar heating and cooling systems design and development. [prototype development

    Science.gov (United States)

    1977-01-01

    The development of twelve prototype solar heating/cooling systems, six heating and six heating and cooling systems, two each for single family, multi-family, and commercial applications, is reported. Schedules and technical discussions, along with illustrations on the progress made from April 1, 1977 through June 30, 1977 are detailed.

  7. Pension Systems Development Problems in Latvia

    OpenAIRE

    Voļskis, Edgars

    2008-01-01

    Edgars Volskis promotion paper „Pension System’s Development Problems in Latvia” analyses the theoretical aspects of establishment of pension systems, observes mechanisms of financing of pension budget and its sources, aspects of establishment and execution of the pension budget. There are also analysed main milestones of development of Latvian pension system from date of regaining of the independence until the completion moment of the latest reform of pension system. Second chapter of the wo...

  8. Multiple IMU system development, volume 1

    Science.gov (United States)

    Landey, M.; Mckern, R.

    1974-01-01

    A redundant gimballed inertial system is described. System requirements and mechanization methods are defined and hardware and software development is described. Failure detection and isolation algorithms are presented and technology achievements described. Application of the system as a test tool for shuttle avionics concepts is outlined.

  9. Development of steering system in network environment

    International Nuclear Information System (INIS)

    We have been developing the steering system, which can successively observe the-data obtained during the numerical computation and change the parameters in the analysis. Moreover, this system is also extended to link the network. By using this system, a user can easily detect errors immediately and achieve the rapid and accurate analysis with lower computation cost. (Author)

  10. Recent development of cellular manufacturing systems

    Indian Academy of Sciences (India)

    P K Arora; A Haleem; M K Singh

    2013-06-01

    Cellular manufacturing system has been proved a vital approach for batch and job shop production systems. Group technology has been an essential tool for developing a cellular manufacturing system. The paper aims to discuss various cell formation techniques and highlights the significant research work done in past over the years and attempts to points out the gap in research.

  11. Sonic hedgehog signaling during nervous system development

    Institute of Scientific and Technical Information of China (English)

    Qin Yang; Peng Xie

    2008-01-01

    The Hedgehog signaling pathway plays a key role in embryonic development and organ formation.Sonic hedgehog signaling participates in nervous system development,regulates proliferation and differentiation of neural stem cells,controls growth and targeting of axons,and contributes to specialization of oligodendrocytes.For further studies of the Sonic hedgehog signaling pathway and for the development of new drugs in the treatment of nervous system diseases,it is beneficial to understand these mechanisms.

  12. Developing Sustainable Life Support System Concepts

    Science.gov (United States)

    Thomas, Evan A.

    2010-01-01

    Sustainable spacecraft life support concepts may allow the development of more reliable technologies for long duration space missions. Currently, life support technologies at different levels of development are not well evaluated against each other, and evaluation methods do not account for long term reliability and sustainability of the hardware. This paper presents point-of-departure sustainability evaluation criteria for life support systems, that may allow more robust technology development, testing and comparison. An example sustainable water recovery system concept is presented.

  13. Tribes of Users and System Developers

    Directory of Open Access Journals (Sweden)

    Sharon Dingley

    2000-05-01

    Full Text Available Effective communication is essential for information systems development crossing functional, organisational and national boundaries. As organisations attempt to overcome cultural barriers to communication across the world, communication with colleagues across the corridor remains problematic; cultural barriers between departments remain unchallenged. This paper introduces the concepts of 'culture' and 'tribe' into the discussion of the relationship between business users and information systems developers. Previous research has focused on identifying specific barriers to user-systems developer communication and on ways of eliminating these barriers. In contrast, this paper suggests that much can be learnt through the recognition of cultural differences inherent to the differing roles of user and systems developer. Maintenance of cultural identity is essential to the individual if he/she is to function effectively as a member of his/her tribe, whether it is the 'tribe' of developers or the 'tribe' of users. Communication problems within the systems development process may be addressed by a mutual understanding of cultural differences between the 'tribes' of users and systems developers. This degree of understanding cannot be achieved by attempting to change, persuade or convert the other tribe. The problems of user-systems developer communication need to be addressed through effective communication which acknowledges the differing cultures.

  14. Dynamical Systems Approaches to Emotional Development

    Science.gov (United States)

    Camras, Linda A.; Witherington, David C.

    2005-01-01

    Within the last 20 years, transitions in the conceptualization of emotion and its development have given rise to calls for an explanatory framework that captures emotional development in all its organizational complexity and variability. Recent attempts have been made to couch emotional development in terms of a dynamical systems approach through…

  15. Natural History and Galsulfase Treatment in Mucopolysaccharidosis VI (MPS VI, Maroteaux-Lamy Syndrome) — 10 Year Follow-up of Patients Who Previously Participated in an MPS VI Survey Study

    Science.gov (United States)

    Giugliani, Roberto; Lampe, Christina; Guffon, Nathalie; Ketteridge, David; Teles, Elisa Leão; Wraith, James E.; Jones, Simon A; Piscia-Nichols, Cheri; Lin, Ping; Quartel, Adrian; Harmatz, Paul

    2014-01-01

    Mucopolysaccharidosis VI (MPS VI) is a clinically heterogeneous and progressive disorder with multiorgan manifestations caused by deficient N-acetlylgalactosamine-4-sulfatase activity. A cross-sectional Survey Study in individuals (n=121) affected with MPS VI was conducted between 2001–2002 to establish demographics, urinary glycosaminoglycan (GAG) levels, and clinical progression of disease. We conducted a Resurvey Study (ClinicalTrials.gov: NCT01387854) to obtain 10-year follow-up data, including medical histories and clinical assessments (n=59), and survival status over 12-years (n=117). Patients received a mean (SD) of 6.8 (2.2) years of galsulfase ERT between baseline (Survey Study) and follow-up. ERT patients increased in height by 20.4 cm in the 4–7 year-old baseline age group and by 16.8 cm in the 8–12 year-old baseline age group. ERT patients 200 µg/mg baseline uGAG levels increased FVC by 48% in the <13 year-old and by 15% in the ≥13 year-old baseline age group. ERT patients who completed the 6-minute walk test demonstrated a mean (SD) increase of 65.7 (100.6) m. Cardiac outcomes did not significantly improve or worsen. Observed mortality rate among naïve patients was 50% (7/14) and 16.5% (17/103) in the ERT group (unadjusted hazard ratio, 0.24; 95% CI, 0.10 to 0.59). Long-term galsulfase ERT was associated with improvements in pulmonary functions and endurance, stabilized cardiac function and increased survival. PMID:24764221

  16. MSFC Lunar Environments Test System (LETS) System Development

    Science.gov (United States)

    Craven, Paul; Vaughn, Jason; Schneider, Todd; Norwood, Joey; Abbas, Mian; Alexander, Reginald

    2009-01-01

    A review of the NASA MSFC Lunar Environment Test System (LETS) System Development is presented. The contents include: 1) MSFC LETS Chamber Status; 2) LETS Simulant Containment Box Development; 3) Tests Conducted in LETS To date: Simulant Dust Migration; 4) Summary; and 5) Forward Work.

  17. Recent Developments on Chaos in Mechanical Systems

    OpenAIRE

    Mohammad Sajid

    2013-01-01

    Recent advancements in complexity of mechanical systems have led to the application of chaos theory. In this paper, some recent developments on chaos in mechanical systems are explored. The aim is to bring together researchers from various interests of mechanical systems, exposing them to chaos theory. This exposure gives researchers from the discipline of mechanical systems to find opportunity of cross disciplinary research, which may ultimately lead to novel solutions and understanding of m...

  18. Development of the Hypothalamic Melanocortin System

    OpenAIRE

    SebastienGBouret

    2013-01-01

    The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC) neurons that act, in part, through the melanocortin-4 receptor (MC4R). Although the importance of the melanocortin system in controlling feeding has been established for two decades, the understanding of the developmental substrates underlying POMC and MC4R neuron development and function has just begun to emerge. ...

  19. Systems Engineering Leadership Development: Advancing Systems Engineering Excellence

    Science.gov (United States)

    Hall, Phil; Whitfield, Susan

    2011-01-01

    This slide presentation reviews the Systems Engineering Leadership Development Program, with particular emphasis on the work being done in the development of systems engineers at Marshall Space Flight Center. There exists a lack of individuals with systems engineering expertise, in particular those with strong leadership capabilities, to meet the needs of the Agency's exploration agenda. Therefore there is a emphasis on developing these programs to identify and train systems engineers. The presentation reviews the proposed MSFC program that includes course work, and developmental assignments. The formal developmental programs at the other centers are briefly reviewed, including the Point of Contact (POC)

  20. System model development for nuclear thermal propulsion

    International Nuclear Information System (INIS)

    A critical enabling technology in the evolutionary development of nuclear thermal propulsion (NTP) is the ability to predict the system performance under a variety of operating conditions. Since October 1991, US (DOE), (DOD) and NASA have initiated critical technology development efforts for NTP systems to be used on Space Exploration Initiative (SEI) missions to the Moon and Mars. This paper presents the strategy and progress of an interagency NASA/DOE/DOD team for NTP system modeling. It is the intent of the interagency team to develop several levels of computer programs to simulate various NTP systems. An interagency team was formed for this task to use the best capabilities available and to assure appropriate peer review. The vision and strategy of the interagency team for developing NTP system models will be discussed in this paper. A review of the progress on the Level 1 interagency model is also presented

  1. Software systems development in petroleum engineering

    Science.gov (United States)

    Browning, D. J.; Cain, G. M.; Carmichael, N. P.; Gouldstone, F. G.; Wadsley, A. W.; Webb, S. J.; Winder, P.

    1985-10-01

    Many approaches to designing software systems have been developed for use in commercial or business environments. These development methods and procedures have improved dramatically over the last ten years although it is only recently that these have been employed in scientific and technological applications. Many of these implementations have been unsuccessful because the design methodology has been divorced from the practical requirements of the industry in which the software system is to operate. This paper discusses a modern approach to software development which directly relates to an engineering environment and which is designed to satisfy practical criteria of acceptability of the software when delivered to the petroleum engineer. Since all field developments nowadays rely heavily on associated software systems, the approach presented here can lead to improved mechanical systems reliability and shorter development/design cycles.

  2. Gas tagging system development in Japan

    International Nuclear Information System (INIS)

    The Gas tagging method has been considered to be most desirable for a failed fuel location system for the fast breeder reactor, regarding the component reduction in the reactor vessel and rapid location during reactor operation. The gas tagging system has been designed by referring to R and D results obtained in Japan and other countries. The designed system is comprised of tag gas filling pins, cover gas sampling system, tag gas recovery and enrichment system, tag gas analyzer and system control and data handling computers. The main specifications for this system have been decided as follows; 1) Main function is location of failed fuels in core and a part of blanket region, 2) Identification capability is each subassembly, 3) Time for identification is within a few days, 4) Continuous operation with automatic start at fuel failure, 5) Detection sensitivity must cover both gas leak and pin burst. In designing the gas tagging system, the following R and D items were selected; 1) System design study, 2) Tag gas capsule development, 3) Modeling the tag gas behavior in reactor primary cooling system, 4) Tag gas recovery and enrichment system, 5) Computer code development for tag gas isotope ratio change estimation. Details of the Japanese gas tagging system development appear in this paper. (author)

  3. Development of the Digital Reactor Safety System

    International Nuclear Information System (INIS)

    Objectives of Project - Development of Digital Safety Grade PLC and Licensing - Development of Safety System(RPS) and Licensing - Development of Safety System(ESF-CCS) and Licensing Content and Result of Project - POSAFE-Q PLC : Development of PLC platform for Shin-UCN unit 1 and 2 ·Development Scope : Processor module, Power module, 3 kinds of Communication module, Bus extension module(Master and Slave), 16 kinds of Input and Output module ·PLC application software development tool(pSET) - IDiPS RPS and IDiPS ESF-CCS : Development of PPS for Sin-UCN 1 and 2 ·Development Scope - 4-channels RPS with the KNICS inherent architecture - A part of 1-channels ESF-CCS with the KNICS inherent architecture - Licensing ·optical Report Submitted and Expected to finish the licensing process until Aug. 2008

  4. Space Shuttle Main Propulsion System Anomaly Detection: A Case Study

    Data.gov (United States)

    National Aeronautics and Space Administration — The space shuttle main engine (SSME) is part of the Main Propnlsion System (MPS) which is an extremely complex system containing several sub-systems and components,...

  5. Development of environment radiation database management system

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Jong Gyu; Chung, Chang Hwa; Ryu, Chan Ho; Lee, Jin Yeong; Kim, Dong Hui; Lee, Hun Sun [Daeduk College, Taejon (Korea, Republic of)

    1999-03-15

    In this development, we constructed a database for efficient data processing and operating of radiation-environment related data. Se developed the source documents retrieval system and the current status printing system that supports a radiation environment dta collection, pre-processing and analysis. And, we designed and implemented the user interfaces and DB access routines based on WWW service policies on KINS Intranet. It is expected that the developed system, which organizes the information related to environmental radiation data systematically can be utilize for the accurate interpretation, analysis and evaluation.

  6. Development of environment radiation database management system

    International Nuclear Information System (INIS)

    In this development, we constructed a database for efficient data processing and operating of radiation-environment related data. Se developed the source documents retrieval system and the current status printing system that supports a radiation environment dta collection, pre-processing and analysis. And, we designed and implemented the user interfaces and DB access routines based on WWW service policies on KINS Intranet. It is expected that the developed system, which organizes the information related to environmental radiation data systematically can be utilize for the accurate interpretation, analysis and evaluation

  7. Prognostication of regional energy system development

    Directory of Open Access Journals (Sweden)

    Grigoriy Borisovich Korovin

    2011-06-01

    Full Text Available This paper analyzes practice and development of new methodological approaches to forecasting the development of regional energy systems. It is shown that the energy complex is involved in a variety of forward and backward linkages as an element of socio-economic systems, and the quality and availability of energy resources largely determines the structure and pace of economic, social and environmental development of the region. Analysis of existing current practice of territorial and sectoral forecasting implemented in Russia and abroad, suggests that such practice is inadequate in its theoretical and methodological elaboration. This is confirmed by the frequent discrepancy between actual results and plans, as well as their regular revision. The methods are mostly based on extrapolation of existing tendencies and not taking into account many factors and emerging trends related to the complexity and openness of the social and economic systems. Post-industrial level of civilization is characterized by fast development of technology; knowledge, information, technological and institutional innovation become the main resources. The greatest importance is attached to such development properties as instability, various orderliness, nonlinearity, interactions etc. Current approaches to forecasting the future are described by a number of theories that are generally called self-organization theory, taking into account these singularities. These concepts should be included in the theoretical basis for the development and implementation of regional development forecasts. Using the synergetic approach assumes that, along with organizational processes, processes of self-organization and self-development are very important in the system, they are characterized by spontaneous, unexpected formations and emerging structures. The development of such systems can generate stable and efficient new structure. The presence of crisis is an integral feature of complex

  8. System theoretic approach to sustainable development problems

    Directory of Open Access Journals (Sweden)

    Batanović Vladan

    2011-01-01

    Full Text Available This paper shows that the concepts and methodology contained in the system theory and operations research are suitable for application in the planning and control of the sustainable development. The sustainable development problems can be represented using the state space concepts, such as the transition of system, from the given initial state to the final state. It is shown that sustainable development represents a specific control problem. The peculiarity of the sustainable development is that the target is to keep the system in the prescribed feasible region of the state space. The analysis of planning and control problems of sustainable development has also shown that methods developed in the operations research area, such as multicriteria optimization, dynamic processes simulation, non-conventional treatment of uncertainty etc. are adequate, exact base, suitable for resolution of these problems.

  9. The Development of Oromo Writing System

    OpenAIRE

    Degeneh Bijiga, Teferi

    2015-01-01

    The development and use of languages for official, education, religion, etc. purposes have been a major political issue in many developing multilingual countries. A number of these countries, including China and India, have recognised the issues and developed language policies that have provided some ethnic groups with the right to develop their languages and cultures by using writing systems based on scripts suitable for these purposes. On the other hand, other countries, such as Ethiopia (a...

  10. Development of Bio-GAS systems

    Science.gov (United States)

    Takayanagi, M.; Kitamura, S.; Nemoto, H.; Kimura, T.; Zaiki, Y.; Kitakohji, T.; Fujita, S.; Kameda, M.; Noda, M.; Kawasaki, Y.

    1988-01-01

    Four experiment systems which have fundamental significance in the field of biotechnology are developed for the Get Away Special (GAS). Unique considerations were necessary to develop the systems which carry out biotechnological experiments under GAS's restricted conditions: delicate thermal control, fluid handling and protection from contamination. All experimental processes are controlled by internal sequencers and results of the experiments are recorded as images and numerical data within the systems. The systems are standardized in order to enable repeated use with a variety of experiments by replacement of the experiment modules and modification of experiment sequencing programs.

  11. Multiple memory systems, development and conditioning.

    Science.gov (United States)

    Stanton, M E

    2000-06-01

    A century of behavioral and neurobiological research suggests that Pavlovian conditioning involves three component memory systems: sensorimotor, affective and cognitive. In classical eyeblink conditioning, there is evidence that these three memory systems involve, respectively, the cerebellum, amygdala and hippocampus. This article reviews developmental research on eyeblink conditioning in rodents that is beginning to characterize ontogenetic dissociations and interactions among these memory systems. This research shows that the functional development of the affective system (conditioned fear response) precedes that of the sensorimotor system (conditioned eyeblink reflex). Modulation of these two systems by cognitive processes also seems to emerge at different points in ontogeny. Implications for cognitive development and research on multiple memory systems are discussed.

  12. Development of the stock exchange information system

    Directory of Open Access Journals (Sweden)

    Miladinović Radojko

    2006-01-01

    Full Text Available The stock exchange represents the key institution for the development of capital market of any country. Thus the information system of every stock exchange must satisfy very strict international standards. The development of these systems is particularly difficult in countries in transition, due to intense economic and legal changes, lack of technical and financial resources, lack of experience and knowledge in the area of the capital market business, etc. Therefore the special software project management methodology for their realization must be clearly defined. In the development process of the Belgrade Stock Exchange (BSE information system a new software project management methodology for its realization has been defined, the application of which is illustrated through a series of different development stages of the Belgrade Stock Exchange information system. In order to make all the problems more comprehensive, only the continuous trading method is described, being the most frequently used trading method in the world.

  13. Research and Development Information System (RDIS)

    Data.gov (United States)

    Department of Veterans Affairs — The Research and Development Information System (RDIS) is the Veterans Affairs Central Office budgetary and project data repository for managing the VA Research and...

  14. On Using Materiality in Information Systems Development

    DEFF Research Database (Denmark)

    Carugati, Andrea

    This research brief presents a discussion on the use of the concept of materiality and material knowing in information systems development (ISD). The discussion addresses some of the practical problems still plaguing ISD, augmenting existing ISD methodologies with contributions from systems theory...... and in particular the idea of inquiring systems. The discussion builds on different contemporary concepts that are rooted in the inquiring systems idea: the notion of stakeholders (designer, client, user and their interchanging roles), the notion boundary object and boundary spanners, and the notion of materiality...... as scaffold of knowledge. Through the example taken from a case study of a complex and innovative systems development we outline two design principles to be embedded in modular fashion in ISD processes: (1) whenever possible start ISD efforts by developing a graphical simulator of the material environment...

  15. Development of Architectures for Internet Telerobotics Systems

    CERN Document Server

    Bambang, Riyanto

    2008-01-01

    This paper presents our experience in developing and implementing Internet telerobotics system. Internet telerobotics system refers to a robot system controlled and monitored remotely through the Internet. A robot manipulator with five degrees of freedom, called Mentor, is employed. Client-server architecture is chosen as a platform for our Internet telerobotics system. Three generations of telerobotics systems have evolved in this research. The first generation was based on CGI and two tiered architecture, where a client presents a Graphical User Interface to the user, and utilizes the user's data entry and actions to perform requests to robot server running on a different machine. The second generation was developed using Java. We also employ Java 3D for creating and manipulating 3D geometry of manipulator links and for constructing the structures used in rendering that geometry, resulting in 3D robot movement simulation presented to the users(clients) through their web browser. Recent development in our In...

  16. System Administrator for LCS Development Sets

    Science.gov (United States)

    Garcia, Aaron

    2013-01-01

    The Spaceport Command and Control System Project is creating a Checkout and Control System that will eventually launch the next generation of vehicles from Kennedy Space Center. KSC has a large set of Development and Operational equipment already deployed in several facilities, including the Launch Control Center, which requires support. The position of System Administrator will complete tasks across multiple platforms (Linux/Windows), many of them virtual. The Hardware Branch of the Control and Data Systems Division at the Kennedy Space Center uses system administrators for a variety of tasks. The position of system administrator comes with many responsibilities which include maintaining computer systems, repair or set up hardware, install software, create backups and recover drive images are a sample of jobs which one must complete. Other duties may include working with clients in person or over the phone and resolving their computer system needs. Training is a major part of learning how an organization functions and operates. Taking that into consideration, NASA is no exception. Training on how to better protect the NASA computer infrastructure will be a topic to learn, followed by NASA work polices. Attending meetings and discussing progress will be expected. A system administrator will have an account with root access. Root access gives a user full access to a computer system and or network. System admins can remove critical system files and recover files using a tape backup. Problem solving will be an important skill to develop in order to complete the many tasks.

  17. The issue of contract system development

    OpenAIRE

    Obalyaeva Julia, I.; Cherniy Andrew, S.

    2015-01-01

    The role of contract system and its institutions in the national economy, the development of public procurement, the rational use of budgetary funds is explored in the paper. Dynamics of purchases in electronic trading for 2011-2014 is given. Author's vision on the problems in the formation and development institutions such as tendering and organization of interaction of participants of procurement on an electronic platform is submitted. Among the institutions of the contract system stand out...

  18. Development of the stock exchange information system

    OpenAIRE

    Miladinović Radojko

    2006-01-01

    The stock exchange represents the key institution for the development of capital market of any country. Thus the information system of every stock exchange must satisfy very strict international standards. The development of these systems is particularly difficult in countries in transition, due to intense economic and legal changes, lack of technical and financial resources, lack of experience and knowledge in the area of the capital market business, etc. Therefore the special software proje...

  19. Development of portable driving simulator system

    OpenAIRE

    Itoh, Y; Nemoto, T.; Matsuura, H.; M. Kihira; S. Yanai

    2008-01-01

    Purpose: In accordance with aging of populations in many developed countries, number of drivers who suffer from mild cognitive impairment (MCI drivers) is increasing. Since it has been reported that driving skill of the MCI drivers are deteriorated, it is important to train themselves in driving situation to preserve their driving skills. The present study was conducted to develop the simple driving simulator system, and to examine the effect of training in this system.Design/methodology/appr...

  20. Testing Infrastructure for Operating System Kernel Development

    DEFF Research Database (Denmark)

    Walter, Maxwell; Karlsson, Sven

    2014-01-01

    -core kernels pose an even greater challenge due to concurrency and their shared kernel state. In this paper, we present a testing framework that addresses these challenges by running the operating system in a virtual machine, and using virtual machine introspection to both communicate with the kernel......Testing is an important part of system development, and to test effectively we require knowledge of the internal state of the system under test. Testing an operating system kernel is a challenge as it is the operating system that typically provides access to this internal state information. Multi...

  1. Developing a system for AMB Monitoring

    CERN Document Server

    Hancock, Thomas

    2015-01-01

    A monitoring system for the Associative Memory Boards (AMBs) of the Fast Tracker (FTK) is developed and tested. This system is able to read out status register values from AMBs and publish them to the Information Service (IS). The system is designed so as to be easily extensible to other boards of FTK, and this is demonstrated through an extension of the systems to be able to monitor FTK Auxiliary cards. Future work will involve extensions to other FTK boards and providing a system to read from IS and present the user with the monitoring data.

  2. Developing operating principles for systems change.

    Science.gov (United States)

    Behrens, Teresa R; Foster-Fishman, Pennie G

    2007-06-01

    Based on an analysis of the articles in this special issue, the authors propose five operating principles for systems change work. These principles are: clarifying the purpose of the systems change; identifying whether the change is one to an existing system or the change is to create a new system; conceptualize the work as systems change from the beginning; use an eclectic approach; and be open to opportunities that emerge while also undertaking forma analysis to identify leverage points. The authors argue that the time is now ripe to develop such principles and encourage community change agents to engage in a dialogue to explore, revise, eliminate or expand on these principles. PMID:17431758

  3. Hydrogen storage and delivery system development: Fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Handrock, J.L.; Malinowski, M.E.; Wally, K. [Sandia National Lab., Livermore, CA (United States)

    1996-10-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a newly developed fuel cell vehicle hydride storage system model will also be discussed. As an example of model use power distribution and control for a simulated driving cycle is presented. An experimental test facility, the Hydride Bed Testing Laboratory (HBTL) has been designed and fabricated. The development of this facility and its use in storage system development will be reviewed. These two capabilities (analytical and experimental) form the basis of an integrated approach to storage system design and development. The initial focus of these activities has been on hydride utilization for vehicular applications.

  4. The Guided System Development Framework: Modeling and Verifying Communication Systems

    DEFF Research Database (Denmark)

    Carvalho Quaresma, Jose Nuno; Probst, Christian W.; Nielson, Flemming

    2014-01-01

    In a world that increasingly relies on the Internet to function, application developers rely on the implementations of protocols to guarantee the security of data transferred. Whether a chosen protocol gives the required guarantees, and whether the implementation does the same, is usually unclear....... The Guided System Development framework contributes to more secure communication systems by aiding the development of such systems. The framework features a simple modelling language, step-wise refinement from models to implementation, interfaces to security verification tools, and code generation from...

  5. The engineering of microprocessor systems guidelines on system development

    CERN Document Server

    1979-01-01

    The Engineering of Microprocessor Systems: Guidelines on System Development provides economical and technical guidance for use when incorporating microprocessors in products or production processes and assesses the alternatives that are available. This volume is part of Project 0251 undertaken by The Electrical Research Association, which aims to give managers and development engineers advice and comment on the development process and the hardware and software needed to support the engineering of microprocessor systems. The results of Phase 1 of the five-phase project are contained in this fir

  6. Developing a Mobile Distance Learning System

    OpenAIRE

    Rogov, Petr; Borisov, Nikolay

    2007-01-01

    This article considers the basic problems of client-server electronic learning systems based on mobile platforms. Such questions as relational learning course model and student’s transitions prediction through the learning course items are considered. Besides, technical questions of electronic learning system “E-Learning Suite” realization and questions of developing portable applications using .NET Framework are discussed.

  7. Financial system development in transition economies

    NARCIS (Netherlands)

    Hermes, C.L.M.; Lensink, B.W.

    2000-01-01

    This paper provides an overview of the major issues with respect to financial system development in transition economies, which were discussed at a conference in Groningen, the Netherlands, December 1997. After a brief remark on the role of financial system design during economic transition, the pap

  8. Development of Smart Underfrequency Load Shedding System

    OpenAIRE

    Čuvičins, V; Petričenko, R

    2012-01-01

    Paper describes possibility to apply innovation technology of Smart Grid for power system emergency automation. Operational characteristics of existing emergency automation and new suggested one are compared in the paper. The method for liquidation of drawback of existing automation is suggested. Paper describes developed mathematical model of intellectual underfrequency load shedding system and its operational algorithms.

  9. THE DEVELOPMENT OF TROLLEYBUS DRIVE BRAKE SYSTEMS

    Directory of Open Access Journals (Sweden)

    A. Safonau

    2011-01-01

    Full Text Available The requirements for trolleybuses brake systems are analyzed. Some results of the studies examined, contemporary trends of developing in this direction are shows. The range of problems whose solution is aimed at creating high-performance brake systems whose increase efficiency and safety of trolleybuses determined.

  10. Work Values System Development during Adolescence

    Science.gov (United States)

    Porfeli, Erik J.

    2007-01-01

    Work values stability, change, and development can be appreciably reduced to a living system model [Ford, D. H. (1994). "Humans as self-constructing living systems: A developmental perspective on behavior and personality" (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum Associates]. This theoretical model includes discrepancy-reducing and…

  11. Development of artificial bionic baroreflex system.

    Science.gov (United States)

    Sunagawa, Kenji; Sugimachi, Masaru

    2010-01-01

    The baroreflex system is the fastest mechanism in the body to regulate arterial pressure. Because the neural system (i.e., autonomic nervous system) mediates the baroreflex and the system operates under the closed-loop condition, the quantitative dynamic characteristics of the baroreflex system remained unknown until recently despite the fact that a countless number of observational and qualitative studies had been conducted. In order to develop the artificial baroreflex system, i.e., the bionic baroreflex system, we first anatomically isolated the carotid sinuses to open the baroreflex loop and identified the open-loop transfer function of the baroreflex system using white noise pressure perturbations. We found that the baroreflex system is basically a lowpass filter and remarkably linear. As an actuator to implement the bionic baroreflex system, we then stimulated the sympathetic efferent nerves at various parts of the baroreflex loop and identified the transfer functions from the stimulation sites to systemic arterial pressure. We found that the actuator responses can be described remarkably well with linear transfer functions. Since transfer functions of the native baroreflex and of the actuator were identified, the controller that is required to reproduce the native baroreflex transfer function can be easily derived from those transfer functions. To examine the performance of bionic baroreflex system, we implemented it animal models of baroreflex failure. The bionic baroreflex system restored normal arterial pressure regulation against orthostatic stresses that is indistinguishable from the native baroreflex system.

  12. The Development of Computer Music Programming Systems

    OpenAIRE

    Lazzarini, Victor

    2013-01-01

    This article traces the history and evolution of Music Programming, from the early off-line synthesis programs of the MUSIC N family to modern realtime interactive systems. It explores the main design characteristics of these systems and their impact on Computer Music. In chronological fashion, the article will examine, with code examples, the development of the early systems into the most common modern languages currently in use. In particular, we will focus on Csound, highlighting its main ...

  13. [Therapy for systemic metabolic disorders based on the detection of basic corneal landmarks in childhood].

    Science.gov (United States)

    Lisch, W; Pitz, S; Geerling, G

    2013-06-01

    Many systemic lysosomal storage disorders show basic corneal opacities already in childhood. The lysosome is a cell organelle, produced by Golgi's apparatus, that is surrounded by a membrane and contains hydrolytic enzymes that break down food molecules, especially proteins and other complex molecules. The ophthalmologist's precise diagnosis of corneal clouding at the slit-lamp may reveal the correct interpretation of the specific lysosomal storage disorder. It is very important to diagnose such diseases as soon as possible because today the development of systemic enzymatic therapies has broadened the therapeutic armamentarium for the current standard of care. The following corneal landmarks of systemic storage diseases and of the modern systemic therapy are presented: cornea verticillata in Fabry's disease, periodic infusion of alpha-galactosidase a; Kayser-Fleischer's ring in Wilson's disease, zinc, trienetin, low copper diet; multiple, punctiform crystals in cystinosis, cysteamine, Raptor RP 103(DR cysteamine) that reduces the cytotoxity in form of continous dissolving of cystine from lysosome, renal transplantation, haematopoietic stem cell transplantation; peripheral ring, but not true lipid arc, and moderate stromal haze in LCAT-deficiency, injection of recombinant enzyme or of encapsulated LCAT-secreting cells; diffuse stromal haze in mucopolysaccharidoses (MPS). Enzyme replacement therapy is currently indicated for MPS I, MPS II, and MPS VI, haematopoietic stem cell transplantation; painful, bilateral pseudo-dendritic opacities in tyrosinemia type II (eponym: Richner-Hanhart syndrome), low phenylalanine and tyrosine diet result in complete disappearance of corneal alterations with a consecutive painfree period. Strict diet during the whole life is necessary to prevent corneal recurrences and the occurrence of palmo-plantar keratoses. Such therapies can enable the patient to lead an otherwise normal life for decades.

  14. Universal quantitative kinase assay based on diagonal SCX chromatography and stable isotope dimethyl labeling provides high-definition kinase consensus motifs for PKA and human Mps1.

    Science.gov (United States)

    Hennrich, Marco L; Marino, Fabio; Groenewold, Vincent; Kops, Geert J P L; Mohammed, Shabaz; Heck, Albert J R

    2013-05-01

    In order to understand cellular signaling, a clear understanding of kinase-substrate relationships is essential. Some of these relationships are defined by consensus recognition motifs present in substrates making them amendable for phosphorylation by designated kinases. Here, we explore a method that is based on two sequential steps of strong cation exchange chromatography combined with differential stable isotope labeling, to define kinase consensus motifs with high accuracy. We demonstrate the value of our method by evaluating the motifs of two very distinct kinases: cAMP regulated protein kinase A (PKA) and human monopolar spindle 1 (Mps1) kinase, also known as TTK. PKA is a well-studied basophilic kinase with a relatively well-defined motif and numerous known substrates in vitro and in vivo. Mps1, a kinase involved in chromosome segregation, has been less well characterized. Its substrate specificity is unclear and here we show that Mps1 is an acidophilic kinase with a striking tendency for phosphorylation of threonines. The final outcomes of our work are high-definition kinase consensus motifs for PKA and Mps1. Our generic method, which makes use of proteolytic cell lysates as a source for peptide-substrate libraries, can be implemented for any kinase present in the kinome.

  15. Phosphorylation of microtubule-binding protein Hec1 by mitotic kinase Aurora B specifies spindle checkpoint kinase Mps1 signaling at the kinetochore.

    Science.gov (United States)

    Zhu, Tongge; Dou, Zhen; Qin, Bo; Jin, Changjiang; Wang, Xinghui; Xu, Leilei; Wang, Zhaoyang; Zhu, Lijuan; Liu, Fusheng; Gao, Xinjiao; Ke, Yuwen; Wang, Zhiyong; Aikhionbare, Felix; Fu, Chuanhai; Ding, Xia; Yao, Xuebiao

    2013-12-13

    The spindle assembly checkpoint (SAC) is a quality control device to ensure accurate chromosome attachment to spindle microtubule for equal segregation of sister chromatid. Aurora B is essential for SAC function by sensing chromosome bi-orientation via spatial regulation of kinetochore substrates. However, it has remained elusive as to how Aurora B couples kinetochore-microtubule attachment to SAC signaling. Here, we show that Hec1 interacts with Mps1 and specifies its kinetochore localization via its calponin homology (CH) domain and N-terminal 80 amino acids. Interestingly, phosphorylation of the Hec1 by Aurora B weakens its interaction with microtubules but promotes Hec1 binding to Mps1. Significantly, the temporal regulation of Hec1 phosphorylation orchestrates kinetochore-microtubule attachment and Mps1 loading to the kinetochore. Persistent expression of phosphomimetic Hec1 mutant induces a hyperactivation of SAC, suggesting that phosphorylation-elicited Hec1 conformational change is used as a switch to orchestrate SAC activation to concurrent destabilization of aberrant kinetochore attachment. Taken together, these results define a novel role for Aurora B-Hec1-Mps1 signaling axis in governing accurate chromosome segregation in mitosis.

  16. The message processing and distribution system development

    Science.gov (United States)

    Whitten, K. L.

    1981-06-01

    A historical approach is used in presenting the life cycle development of the Navy's message processing and distribution system beginning with the planning phase and ending with the integrated logistic support phase. Several maintenance problems which occurred after the system was accepted for fleet use were examined to determine if they resulted from errors in the acquisition process. The critical decision points of the acquisition process are examined and constructive recommendations are made for avoiding the problems which hindered the successful development of this system.

  17. MODEL DRIVEN DEVELOPMENT OF ONLINE BANKING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Bresfelean Vasile Paul

    2011-07-01

    Full Text Available In case of online applications the cycle of software development varies from the routine. The online environment, the variety of users, the treatability of the mass of information created by them, the reusability and the accessibility from different devices are all factors of these systems complexity. The use of model drive approach brings several advantages that ease up the development process. Working prototypes that simplify client relationship and serve as the base of model tests can be easily made from models describing the system. These systems make possible for the banks clients to make their desired actions from anywhere. The user has the possibility of accessing information or making transactions.

  18. Development of the simulation monitoring system

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Katsumi [Research Organization for Information Science and Technology, Tokai, Ibaraki (Japan); Watanabe, Tadashi; Kume, Etsuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-01-01

    Large-scale simulation technique is studied at the Center for Promotion of Computational Science and Engineering for the computational science research in nuclear fields. Visualization and animation processing techniques are developed for efficient understanding of simulation results. The development of the simulation monitoring system, which is used for real-time visualization of ongoing simulations or for successive visualization of calculated results, is described in this report. The standard visualization tool AVS5 or AVS/EXPRESS is used for the simulation monitoring system, and thus, this system can be utilized in various computer environments. (author)

  19. Online Faculty Development and Assessment System (OFDAS)

    OpenAIRE

    Luis M. Villar; Olga M. Alegre

    2006-01-01

    The rapid growth of online learning has led to the development of faculty inservice evaluation models focused on quality improvement of degree programs. Based on current 'best practices' of student online assessment, the Online Faculty Development and Assessment System (OFDAS), created at the Canary Islands, was designed to serve the dual purpose of faculty development and classroom learning environment assessment. Results, as illustrated in this paper, show that the OFDAS encouraged faculty ...

  20. PLM system support for modular product development

    DEFF Research Database (Denmark)

    Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik; Harlou, Ulf;

    2015-01-01

    properties such as cost and performance. Companies often use a PLM tool for management of CAD files, documents, and drawings, but they do not take advantage of the full potential of the PLM system to support the development activities of modular product designs. The key result of this paper...... (PDM) and product lifecycle management (PLM) systems offer support by automating and managing some of the operational complexity of modular design activities. PLM system tools are used for handling a variety of product definitions, to manage workflow of development activities, and to measure relational...... is the description of an empirical tested approach using a visual product architecture representation in combination with a PLM system to support the development of a product family of products. The results from the study encompass new PLM capabilities for handling multiple product structures, visualising multiple...

  1. Development of Architectures for Internet Telerobotics Systems

    Institute of Scientific and Technical Information of China (English)

    Riyanto T. Bambang

    2007-01-01

    This paper presents our experience in developing and implementing Internet telerobotics system. Internet telerobotics system refers to a robot system controlled and monitored remotely through the Internet. A robot manipulator with five degrees of freedom, called Mentor, is employed. Client-server architecture is chosen as a platform for our Internet telerobotics system.Three generations of telerobotics systems have evolved in this research. The first generation was based on CGI and two tiered architectures, where a client presents a Graphical User Interface to the user, and utilizes the user's data entry and actions to perform requests to robot server running on a different machine. The second generation was developed using Java. We also employ Java 3D for creating and manipulating 3D geometry of manipulator links, and for constructing the structures used in rendering that geometry, resulting in 3D robot movement simulation presented to the users (clients) through their web browser.Recent development in our Internet telerobotics includes object recognition through image captured by a camera, which poses challenging problem, giving the undeterministic latency of the Internet. The third generation is centered around the use of CORBA for development platform of distributed internet telerobotics system, aimed at distributing task of telerobotics system.

  2. Proximity sensor system development. CRADA final report

    International Nuclear Information System (INIS)

    Lockheed Martin Energy Research Corporation (LMERC) and Merritt Systems, Inc. (MSI) entered into a Cooperative Research and Development Agreement (CRADA) for the development and demonstration of a compact, modular proximity sensing system suitable for application to a wide class of manipulator systems operated in support of environmental restoration and waste management activities. In teleoperated modes, proximity sensing provides the manipulator operator continuous information regarding the proximity of the manipulator to objects in the workspace. In teleoperated and robotic modes, proximity sensing provides added safety through the implementation of active whole arm collision avoidance capabilities. Oak Ridge National Laboratory (ORNL), managed by LMERC for the United States Department of Energy (DOE), has developed an application specific integrated circuit (ASIC) design for the electronics required to support a modular whole arm proximity sensing system based on the use of capacitive sensors developed at Sandia National Laboratories. The use of ASIC technology greatly reduces the size of the electronics required to support the selected sensor types allowing deployment of many small sensor nodes over a large area of the manipulator surface to provide maximum sensor coverage. The ASIC design also provides a communication interface to support sensor commands from and sensor data transmission to a distributed processing system which allows modular implementation and operation of the sensor system. MSI is a commercial small business specializing in proximity sensing systems based upon infrared and acoustic sensors

  3. Rock support system development test plan

    International Nuclear Information System (INIS)

    The Test Plan has been prepared to support design activities for the development of a rock support system for a Nuclear Waste Repository in Basalt (NWRB). The rock support system is assumed to consist of a combination of shotcrete and rock bolts. The seven testing activities include mix development and physical testing of shotcrete, durability testing of shotcrete, durability testing of rock bolt grouts, field tests on rock bolts, field testing of shotcrete, and heated room test. The objective of the Test Plan is to develop required data through combined laboratory, field, and office studies for design and design validation of the rock support system. The overall Test Plan is developed to provide a logical progression from laboratory tests performed to characterize fundamental thermomechanical properties of shotcrete and grouts, to field tests on rock bolts and shotcrete, and in situ performance tests. 21 refs., 15 figs., 33 tabs

  4. Development of an automatic pipeline scanning system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae H.; Lee, Jae C.; Moon, Soon S.; Eom, Heung S.; Choi, Yu R

    1999-11-01

    Pressure pipe inspection in nuclear power plants is one of the mandatory regulation items. Comparing to manual ultrasonic inspection, automatic inspection has the benefits of more accurate and reliable inspection results and reduction of radiation disposal. final object of this project is to develop an automatic pipeline inspection system of pressure pipe welds in nuclear power plants. We developed a pipeline scanning robot with four magnetic wheels and 2-axis manipulator for controlling ultrasonic transducers, and developed the robot control computer which controls the robot to navigate along inspection path exactly. We expect our system can contribute to reduction of inspection time, performance enhancement, and effective management of inspection results. The system developed by this project can be practically used for inspection works after field tests. (author)

  5. The issue of contract system development

    Directory of Open Access Journals (Sweden)

    Obalyaeva Julia, I.

    2015-09-01

    Full Text Available The role of contract system and its institutions in the national economy, the development of public procurement, the rational use of budgetary funds is explored in the paper. Dynamics of purchases in electronic trading for 2011-2014 is given. Author's vision on the problems in the formation and development institutions such as tendering and organization of interaction of participants of procurement on an electronic platform is submitted. Among the institutions of the contract system stand out: the staff, the system of institutional relations, study, planning and regulation of public procurement, unified information system. The authors suggest possible ways of increasing the efficiency of electronic platforms, the formation of a unified information system. It addresses the issue of affiliation of the bidders, its content, assesses customer actions on the part of the Federal Antimonopoly Service.

  6. Development of a Radioactive Waste Assay System

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Duck Won; Song, Myung Jae; Shin, Sang Woon; Sung, Kee Bang; Ko, Dae Hach [Korea Electric Power Research Institute, Taejon (Korea, Republic of); Kim, Kil Jeong; Park, Jong Mook; Jee, Kwang Yoong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1996-12-31

    Nuclear Act of Korea requires the manifest of low and intermediate level radioactive waste generated at nuclear power plants prior to disposal sites.Individual history records of the radioactive waste should be contained the information about the activity of nuclides in the drum, total activity, weight, the type of waste. A fully automated nuclide analysis assay system, non-destructive analysis and evaluation system of the radioactive waste, was developed through this research project. For the nuclides that could not be analysis directly by MCA, the activities of the representative {gamma}-emitters(Cs-137, Co-60) contained in the drum were measured by using that system. Then scaling factors were used to calculate the activities of {alpha}, {beta}-emitters. Furthermore, this system can automatically mark the analysis results onto the drum surface. An automated drum handling system developed through this research project can reduce the radiation exposure to workers. (author). 41 refs., figs.

  7. Systems analysis for the development of small resource recovery systems: research and development needs. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Crnkovich, P G; Helmstetter, A J

    1980-10-01

    The technologies that should be developed to make small-scale solid waste processing facilities attractive and viable for small municipalities with solid waste between 50 and 250 tons per day are identified. Research and development needs for refuse derived fuel systems, thermal systems, and biological processes are listed. Selected research and development needs discussed for mechanical processing systems are: develop data bank for low-cost, low-energy shredder options; develop performance data for shredders applied after separation; develop data bank for Trommel performance; and identification and evaluation of low-cost materials separation equipment. Selected research and development needs discussed for thermal systems are: emission levels from solid/waste/to/energy systems; determination of the theoretical efficiencies for thermal processing systems; boiler erosion/corrosion evaluation for systems firing refuse derived fuel; optimization of feed and ash handling systems; refractory life and maintenance requirements; development of 5- to 20-TPD systems; and optimization studies of control systems for small modular incinerators. Selected research and development needs discussed for biological processing systems are: optimum design and operation to maximize gas recovery rates and investigate process configuration alternatives for anaerobic digesters.

  8. Development of Solar Powered Irrigation System

    International Nuclear Information System (INIS)

    Development of a solar powered irrigation system has been discussed in this paper. This system would be SCADA-based and quite useful in areas where there is plenty of sunshine but insufficient water to carry out farming activities, such as rubber plantation, strawberry plantation, or any plantation, that requires frequent watering. The system is powered by solar system as a renewable energy which uses solar panel module to convert Sunlight into electricity. The development and implementation of an automated SCADA controlled system that uses PLC as a controller is significant to agricultural, oil and gas monitoring and control purpose purposes. In addition, the system is powered by an intelligent solar system in which solar panel targets the radiation from the Sun. Other than that, the solar system has reduced energy cost as well as pollution. The system is equipped with four input sensors; two soil moisture sensors, two level detection sensors. Soil moisture sensor measures the humidity of the soil, whereas the level detection sensors detect the level of water in the tank. The output sides consist of two solenoid valves, which are controlled respectively by two moistures sensors

  9. Development of Solar Powered Irrigation System

    Science.gov (United States)

    Abdelkerim, A. I.; Sami Eusuf, M. M. R.; Salami, M. J. E.; Aibinu, A.; Eusuf, M. A.

    2013-12-01

    Development of a solar powered irrigation system has been discussed in this paper. This system would be SCADA-based and quite useful in areas where there is plenty of sunshine but insufficient water to carry out farming activities, such as rubber plantation, strawberry plantation, or any plantation, that requires frequent watering. The system is powered by solar system as a renewable energy which uses solar panel module to convert Sunlight into electricity. The development and implementation of an automated SCADA controlled system that uses PLC as a controller is significant to agricultural, oil and gas monitoring and control purpose purposes. In addition, the system is powered by an intelligent solar system in which solar panel targets the radiation from the Sun. Other than that, the solar system has reduced energy cost as well as pollution. The system is equipped with four input sensors; two soil moisture sensors, two level detection sensors. Soil moisture sensor measures the humidity of the soil, whereas the level detection sensors detect the level of water in the tank. The output sides consist of two solenoid valves, which are controlled respectively by two moistures sensors.

  10. Hydrogen storage and delivery system development

    Energy Technology Data Exchange (ETDEWEB)

    Handrock, J.L.; Wally, K.; Raber, T.N. [Sandia National Labs., Livermore, CA (United States)

    1995-09-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. The purpose of this project is to develop a platform for the engineering evaluation of hydrogen storage and delivery systems with an added focus on lightweight hydride utilization. Hybrid vehicles represent the primary application area of interest, with secondary interests including such items as existing vehicles and stationary uses. The near term goal is the demonstration of an internal combustion engine/storage/delivery subsystem. The long term goal is optimization of storage technologies for both vehicular and industrial stationary uses. In this project an integrated approach is being used to couple system operating characteristics to hardware development. A model has been developed which integrates engine and storage material characteristics into the design of hydride storage and delivery systems. By specifying engine operating parameters, as well as a variety of storage/delivery design features, hydride bed sizing calculations are completed. The model allows engineering trade-off studies to be completed on various hydride material/delivery system configurations. A more generalized model is also being developed to allow the performance characteristics of various hydrogen storage and delivery systems to be compared (liquid, activated carbon, etc.). Many of the features of the hydride storage model are applicable to the development of this more generalized model.

  11. Cryogenic Propellant Feed System Analytical Tool Development

    Science.gov (United States)

    Lusby, Brian S.; Miranda, Bruno M.; Collins, Jacob A.

    2011-01-01

    The Propulsion Systems Branch at NASA s Lyndon B. Johnson Space Center (JSC) has developed a parametric analytical tool to address the need to rapidly predict heat leak into propellant distribution lines based on insulation type, installation technique, line supports, penetrations, and instrumentation. The Propellant Feed System Analytical Tool (PFSAT) will also determine the optimum orifice diameter for an optional thermodynamic vent system (TVS) to counteract heat leak into the feed line and ensure temperature constraints at the end of the feed line are met. PFSAT was developed primarily using Fortran 90 code because of its number crunching power and the capability to directly access real fluid property subroutines in the Reference Fluid Thermodynamic and Transport Properties (REFPROP) Database developed by NIST. A Microsoft Excel front end user interface was implemented to provide convenient portability of PFSAT among a wide variety of potential users and its ability to utilize a user-friendly graphical user interface (GUI) developed in Visual Basic for Applications (VBA). The focus of PFSAT is on-orbit reaction control systems and orbital maneuvering systems, but it may be used to predict heat leak into ground-based transfer lines as well. PFSAT is expected to be used for rapid initial design of cryogenic propellant distribution lines and thermodynamic vent systems. Once validated, PFSAT will support concept trades for a variety of cryogenic fluid transfer systems on spacecraft, including planetary landers, transfer vehicles, and propellant depots, as well as surface-based transfer systems. The details of the development of PFSAT, its user interface, and the program structure will be presented.

  12. PSSD - Planning System for Sustainable Development

    DEFF Research Database (Denmark)

    PSSD - Planning System for Sustainable Development - is a part of the Baltic Sea Region's INTERREG II C program. The current report describes some theories, methods and tools developed under the PSSD project. First, the theoretical foundation of the project is described. Secondly, the role...... of indicators in sustainable development is discussed and a Web-based indicator generator is described. Thirdly, we describe a number of methods and tools, which support planning for sustainable development. Finally, some technical interface tools - especially a Web-based interface to the methods and tools...

  13. Clover development during spaceflight: A model system

    Science.gov (United States)

    Guikema, James A.; Debell, Lynnette; Paulsen, Avelina; Spooner, Brian S.; Wong, Peter P.

    1994-08-01

    The development of legume root nodules was studied as a model system for the examination of gravitational effects on plant root development. In order to examine whether rhizobial association with clover roots can be achieved in microgravity, experiments were performed aboard the KC-135 parabolic aircraft and aboard the sounding rocket mission Consort 3. Binding of rhizobia to roots and the initial stages of root nodule development successfully occurred in microgravity. Seedling germination experiments were performed in the sliding block device, the Materials Dispersion Apparatus, aboard STS-37. When significant hydration of the seeds was achieved, normal rates of germination and seedling development were observed.

  14. Development of the Hypothalamic Melanocortin System

    Directory of Open Access Journals (Sweden)

    Berengere eCoupe

    2013-03-01

    Full Text Available The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC neurons that act, in part, through the melanocortin-4 receptor (MC4R. Although the importance of the melanocortin system in controlling feeding has been established for two decades, the understanding of the developmental substrates underlying POMC and MC4R neuron development and function has just begun to emerge. The formation of the melanocortin system involves several discrete developmental steps that include the birth and fate specification of POMC- and MC4R-containing neurons and the extension and guidance of POMC axons to their MC4R-expressing target nuclei. Each of these developmental processes appears to require specific sets of genes and developmental cues that include perinatal hormones. Recent evidence has also highlighted the importance of perinatal nutrition in controlling the ultimate architecture of the melanocortin system.

  15. Development of Digitex premier digital angiographic systems

    Energy Technology Data Exchange (ETDEWEB)

    Miura, Yoshiaki; Miura, Yusuke; Goto, Keiichi; Imanishi, Tetsuo; Miyamoto, Wataru [Shimadzu Corp., Medical Systems Division, Kyoto (Japan)

    2003-06-01

    The technique of interventional radiology has come to be widely utilized in the field of angiography. This has brought forth a strong demand that digital angiographic systems provide high efficiency in patient examinations and high level of interventional support. This report refers to our newly developed Digitex Premier Series digital angiographic systems, designed to meet the above demands. The new systems utilize a high-speed, wide-range C-arm system, a high-resolution image intensifier, a fluid-lubricant X-ray tube, and a digital image processing system, in order to ensure high patient examination efficiency. Their IVR (interventional radiology)-Master bed-side image controller further enhances the efficiency of patient examinations, and also, their CAT (comfortable angio terminal) and FMC (file management console) improve the patient examination throughput and diagnostic workflow of the systems. (author)

  16. Groundwork for Universal Canister System Development

    Energy Technology Data Exchange (ETDEWEB)

    Price, Laura L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gross, Mike [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Prouty, Jeralyn L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rigali, Mark J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Craig, Brian [Argonne National Lab. (ANL), Argonne, IL (United States); Han, Zenghu [Argonne National Lab. (ANL), Argonne, IL (United States); Lee, John Hok [Argonne National Lab. (ANL), Argonne, IL (United States); Liu, Yung [Argonne National Lab. (ANL), Argonne, IL (United States); Pope, Ron [Argonne National Lab. (ANL), Argonne, IL (United States); Connolly, Kevin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Feldman, Matt [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jarrell, Josh [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Radulescu, Georgeta [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Scaglione, John [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wells, Alan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    The mission of the United States Department of Energy's Office of Environmental Management is to complete the safe cleanup of the environmental legacy brought about from five decades of nuclear weapons development and go vernment - sponsored nuclear energy re search. S ome of the waste s that that must be managed have be en identified as good candidates for disposal in a deep borehole in crystalline rock (SNL 2014 a). In particular, wastes that can be disposed of in a small package are good candidates for this disposal concept. A canister - based system that can be used for handling these wastes during the disposition process (i.e., storage, transfers, transportation, and disposal) could facilitate the eventual disposal of these wastes. This report provides information for a program plan for developing specifications regarding a canister - based system that facilitates small waste form packaging and disposal and that is integrated with the overall efforts of the DOE's Office of Nuclear Energy Used Fuel Dis position Camp aign's Deep Borehole Field Test . Groundwork for Universal Ca nister System Development September 2015 ii W astes to be considered as candidates for the universal canister system include capsules containing cesium and strontium currently stored in pools at the Hanford Site, cesium to be processed using elutable or nonelutable resins at the Hanford Site, and calcine waste from Idaho National Laboratory. The initial emphasis will be on disposal of the cesium and strontium capsules in a deep borehole that has been drilled into crystalline rock. Specifications for a universal canister system are derived from operational, performance, and regulatory requirements for storage, transfers, transportation, and disposal of radioactive waste. Agreements between the Department of Energy and the States of Washington and Idaho, as well as the Deep Borehole Field Test plan provide schedule requirements for development of the universal canister system

  17. Modified projective synchronization of a fractional-order hyperchaotic system with a single driving variable

    Institute of Scientific and Technical Information of China (English)

    Wang Xing-Yuan; Zhang Yong-Lei

    2011-01-01

    In this paper,the modified projective synchronization (MPS) of a fractional-order hyperchaotic system is investigated.We design the response system corresponding to the drive system on the basis of projective synchronization theory,and determine the sufficient condition for the synchronization of the drive system and the response system based on fractional-order stability theory.The MPS of a fractional-order hyperchaotic system is achieved by transmitting a single variable.This scheme reduces the information transmission in order to achieve the synchronization,and extends the applicable scope of MPS.Numerical simulations further demonstrate the feasibility and the effectiveness of the proposed scheme.

  18. Hydrogen storage and delivery system development: Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Handrock, J.L. [Sandia National Labs., Livermore, CA (United States)

    1996-10-01

    Hydrogen storage and delivery is an important element in effective hydrogen utilization for energy applications and is an important part of the FY1994-1998 Hydrogen Program Implementation Plan. This project is part of the Field Work Proposal entitled Hydrogen Utilization in Internal Combustion Engines (ICE). The goal of the Hydrogen Storage and Delivery System Development Project is to expand the state-of-the-art of hydrogen storage and delivery system design and development. At the foundation of this activity is the development of both analytical and experimental evaluation platforms. These tools provide the basis for an integrated approach for coupling hydrogen storage and delivery technology to the operating characteristics of potential hydrogen energy use applications. Results of the analytical model development portion of this project will be discussed. Analytical models have been developed for internal combustion engine (ICE) hybrid and fuel cell driven vehicles. The dependence of hydride storage system weight and energy use efficiency on engine brake efficiency and exhaust temperature for ICE hybrid vehicle applications is examined. Results show that while storage system weight decreases with increasing engine brake efficiency energy use efficiency remains relatively unchanged. The development, capability, and use of a recently developed fuel cell vehicle storage system model will also be discussed. As an example of model use, power distribution and control for a simulated driving cycle is presented. Model calibration results of fuel cell fluid inlet and exit temperatures at various fuel cell idle speeds, assumed fuel cell heat capacities, and ambient temperatures are presented. The model predicts general increases in temperature with fuel cell power and differences between inlet and exit temperatures, but under predicts absolute temperature values, especially at higher power levels.

  19. Intrinsic Motivation Systems for Autonomous Mental Development

    OpenAIRE

    Oudeyer, Pierre-Yves; Kaplan, Frederic; Hafner, Verena

    2007-01-01

    Exploratory activities seem to be intrinsically rewarding for children and crucial for their cognitive development. Can a machine be endowed with such an intrinsic motivation system? This is the question we study in this paper, presenting a number of computational systems that try to capture this drive towards novel or curious situations. After discussing related research coming from developmental psychology, neuroscience, developmental robotics, and active learning, this paper prese...

  20. A Guerilla Approach to Control System Development

    OpenAIRE

    Dovc, J.; Milcinski, G; Plesko, M.

    2001-01-01

    We present our experiences in managing the development cycles of the control systems for ANKA and the ALMA Common Software. Our team consists practically only of undergraduate students. Stimulating and rewarding the students with cutting-edge technologies and travel to conferences like this and installation fieldwork are an important positive factor in raising their motivation. However, building any system with a group of inexperienced students is quite a challenging task. Many problems occur...

  1. A Software Development Platform for Mechatronic Systems

    DEFF Research Database (Denmark)

    Guan, Wei

    . Especially, the latter methods employ appropriate techniques and tools for dierent aspects of design issues. Finally, the tool-chain supporting these technology is evaluated comparatively to validate the proposed methods and identify the advantages and disadvantages of the technologies developed in this work.......Software has become increasingly determinative for development of mechatronic systems, which underscores the importance of demands for shortened time-to-market, increased productivity, higher quality, and improved dependability. As the complexity of systems is dramatically increasing, these demands...

  2. Development of a nursing automated documentation system.

    Science.gov (United States)

    Holmes, S B; Fuhrmann, M; Ivancin, L

    1992-01-01

    As hospital length of stay has decreased and patient acuity has increased, the nurse is confronted daily with the challenge of managing time between patient care and documentation. Documentation of care has consistently been a time-consuming and frustrating part of nursing practice. The nursing shortage has only compounded this problem. St. Joseph's Hospital has creatively begun to facilitate documentation by developing a Nursing Automated Documentation System (NADS) in collaboration with CliniCom, Inc. of Boulder, Colorado. This article documents the development and implementation of the system.

  3. Development of an automatic reactor inspection system

    International Nuclear Information System (INIS)

    Using recent technologies on a mobile robot computer science, we developed an automatic inspection system for weld lines of the reactor vessel. The ultrasonic inspection of the reactor pressure vessel is currently performed by commercialized robot manipulators. Since, however, the conventional fixed type robot manipulator is very huge, heavy and expensive, it needs long inspection time and is hard to handle and maintain. In order to resolve these problems, we developed a new automatic inspection system using a small mobile robot crawling on the vertical wall of the reactor vessel. According to our conceptual design, we developed the reactor inspection system including an underwater inspection robot, a laser position control subsystem, an ultrasonic data acquisition/analysis subsystem and a main control subsystem. We successfully carried out underwater experiments on the reactor vessel mockup, and real reactor ready for Ulchine nuclear power plant unit 6 at Dusan Heavy Industry in Korea. After this project, we have a plan to commercialize our inspection system. Using this system, we can expect much reduction of the inspection time, performance enhancement, automatic management of inspection history, etc. In the economic point of view, we can also expect import substitution more than 4 million dollars. The established essential technologies for intelligent control and automation are expected to be synthetically applied to the automation of similar systems in nuclear power plants

  4. Some problems in large superconducting system development

    International Nuclear Information System (INIS)

    The experience in developments of large superconducting magnetic systems (SMS) for investigations into controlled fusion, accumulated in the Kurchatov Institute of Atomic Energy, is analyzed. The early operating SMS of the immersion and circulation type are described. The specifications of SMS being developed are presented. The advantages of circulation-type devices over the immersion-type ones are demostrated. The prospects for use of SMS on multistrand intermetallic materials are briefly outlined

  5. Development of materials supply system requirements

    OpenAIRE

    Brynning, Nicklas; Kihlström, Joakim

    2010-01-01

    In industry today, the need for excellent product development and realization in many different aspects is increasing. This calls for excellent quality, while at the same time time-to-market is increasingly important. A concurrent engineering (CE) approach is directed towards simultaneously developing different aspects of product realization in order to enhance both quality and speed. This thesis deals with the internal materials supply system (MSS) from a CE approach. Logistics aspects are o...

  6. Development of KSTAR Neutral Beam Heating System

    Energy Technology Data Exchange (ETDEWEB)

    Oh, B. H.; Song, W. S.; Yoon, B. J. (and others)

    2007-10-15

    The prototype components of a neutral beam injection (NBI) system have been developed for the KSTAR, and a capability of the manufactured components has been tested. High power ion source, acceleration power supply, other ion source power supplies, neutralizer, bending magnet for ion beam separation, calorimeter, and cryo-sorption pump have been developed by using the domestic technologies and tested for a neutral beam injection of 8 MW per beamline with a pulse duration of 300 seconds. The developed components have been continuously upgraded to achieve the design requirements. The development technology of high power and long pulse neutral beam injection system has been proved with the achievement of 5.2 MW output for a short pulse length and 1.6 MW output for a pulse length of 300 seconds. Using these development technologies, the domestic NB technology has been stabilized under the development of high power ion source, NB beamline components, high voltage and current power supplies, NB diagnostics, NB system operation and control.

  7. Development of automatic laser welding system

    International Nuclear Information System (INIS)

    Laser are a new production tool for high speed and low distortion welding and applications to automatic welding lines are increasing. IHI has long experience of laser processing for the preservation of nuclear power plants, welding of airplane engines and so on. Moreover, YAG laser oscillators and various kinds of hardware have been developed for laser welding and automation. Combining these welding technologies and laser hardware technologies produce the automatic laser welding system. In this paper, the component technologies are described, including combined optics intended to improve welding stability, laser oscillators, monitoring system, seam tracking system and so on. (author)

  8. Telerobotic work system: Concept development and evolution

    Science.gov (United States)

    Jenkins, Lyle M.

    1987-01-01

    The basic concept of a telerobotic work system (TWS) consists of two dexterous manipulator arms controlled from a remote station. The term telerobotic describes a system that is a combination of teleoperator control and robotic operation. Work represents the function of producing physical changes. System describes the integration of components and subsystems to effectively accomplish the needed mission. Telerobotics reduces exposure to hazards for flight crewmembers and increases their productivity. The requirements for the TWS are derived from both the mission needs and the functional capabilities of existing hardware and software to meet those needs. The development of the TWS is discussed.

  9. Developing stereo image based robot control system

    Energy Technology Data Exchange (ETDEWEB)

    Suprijadi,; Pambudi, I. R.; Woran, M.; Naa, C. F; Srigutomo, W. [Department of Physics, FMIPA, InstitutTeknologi Bandung Jl. Ganesha No. 10. Bandung 40132, Indonesia supri@fi.itb.ac.id (Indonesia)

    2015-04-16

    Application of image processing is developed in various field and purposes. In the last decade, image based system increase rapidly with the increasing of hardware and microprocessor performance. Many fields of science and technology were used this methods especially in medicine and instrumentation. New technique on stereovision to give a 3-dimension image or movie is very interesting, but not many applications in control system. Stereo image has pixel disparity information that is not existed in single image. In this research, we proposed a new method in wheel robot control system using stereovision. The result shows robot automatically moves based on stereovision captures.

  10. Water system microbial check valve development

    Science.gov (United States)

    Colombo, G. V.; Greenley, D. R.; Putnam, D. F.

    1978-01-01

    Development work on a device for the Space Shuttle that will prevent the transfer of viable microorganisms within water systems is described. The device serves as a check valve in that it prevents the transfer or cross-contamination of microorganisms from a nonpotable system into a potable water system when these systems are interconnected. In this regard, the function of the device is similar to that of the air gap found in conventional one gravity systems. The device is essentially a bed of resin material impregnated with iodine. Basic design data for a variety of flow and temperature conditions are presented, together with results of challenging the beds with suspensions of seven microorganisms including aerobes, anaerobes, and spore formers.

  11. System for Anomaly and Failure Detection (SAFD) system development

    Science.gov (United States)

    Oreilly, D.

    1992-07-01

    This task specified developing the hardware and software necessary to implement the System for Anomaly and Failure Detection (SAFD) algorithm, developed under Technology Test Bed (TTB) Task 21, on the TTB engine stand. This effort involved building two units; one unit to be installed in the Block II Space Shuttle Main Engine (SSME) Hardware Simulation Lab (HSL) at Marshall Space Flight Center (MSFC), and one unit to be installed at the TTB engine stand. Rocketdyne personnel from the HSL performed the task. The SAFD algorithm was developed as an improvement over the current redline system used in the Space Shuttle Main Engine Controller (SSMEC). Simulation tests and execution against previous hot fire tests demonstrated that the SAFD algorithm can detect engine failure as much as tens of seconds before the redline system recognized the failure. Although the current algorithm only operates during steady state conditions (engine not throttling), work is underway to expand the algorithm to work during transient condition.

  12. Development of Human System Integration at NASA

    Science.gov (United States)

    Whitmore, Mihriban; McGuire, Kerry; Thompson, Shelby; Vos, Gordon

    2012-01-01

    Human Systems Integration seeks to design systems around the capabilities and limitations of the humans which use and interact with the system, ensuring greater efficiency of use, reduced error rates, and less rework in the design, manufacturing and operational deployment of hardware and software. One of the primary goals of HSI is to get the human factors practitioner involved early in the design process. In doing so, the aim is to reduce future budget costs and resources in redesign and training. By the preliminary design phase of a project nearly 80% of the total cost of the project is locked in. Potential design changes recommended by evaluations past this point will have little effect due to lack of funding or a huge cost in terms of resources to make changes. Three key concepts define an effective HSI program. First, systems are comprised of hardware, software, and the human, all of which operate within an environment. Too often, engineers and developers fail to consider the human capacity or requirements as part of the system. This leads to poor task allocation within the system. To promote ideal task allocation, it is critical that the human element be considered early in system development. Poor design, or designs that do not adequately consider the human component, could negatively affect physical or mental performance, as well as, social behavior. Second, successful HSI depends upon integration and collaboration of all the domains that represent acquisition efforts. Too often, these domains exist as independent disciplines due to the location of expertise within the service structure. Proper implementation of HSI through participation would help to integrate these domains and disciplines to leverage and apply their interdependencies to attain an optimal design. Via this process domain interests can be integrated to perform effective HSI through trade-offs and collaboration. This provides a common basis upon which to make knowledgeable decisions. Finally

  13. Mobile Systems Development: An Empirical Study

    DEFF Research Database (Denmark)

    Hosbond, J. H.

    As part of an ongoing study on mobile systems development (MSD), this paper presents preliminary findings of research-in-progress. The debate on mobility in research has so far been dominated by mobile HCI, technological innovations, and socio-technical issues related to new and emerging mobile w...

  14. Redesigning Health Information Systems in Developing Countries

    DEFF Research Database (Denmark)

    Mengiste, Shegaw Anagaw; Kimaro, Honest; Aanestad, Margunn

    2008-01-01

    Despite widespread aims to strengthen the Health Information System (HIS) as a tool for decentralised health care, there is a strong tendency in most developing countries that the HIS continues to reflect the central level's needs and requirements. The traditional design approach with little...

  15. Teaching Information Systems Development via Process Variants

    Science.gov (United States)

    Tan, Wee-Kek; Tan, Chuan-Hoo

    2010-01-01

    Acquiring the knowledge to assemble an integrated Information System (IS) development process that is tailored to the specific needs of a project has become increasingly important. It is therefore necessary for educators to impart to students this crucial skill. However, Situational Method Engineering (SME) is an inherently complex process that…

  16. Developing a Package Training System for Industry

    Science.gov (United States)

    Battersby, D. L. N.

    1974-01-01

    The hotel and catering industry is one of Great Britain's largest. A packaged training system has been developed to satisfy the needs of this industry, an ever-growing occupational field with multiple categories. The material provided in each package outlines short pieces of instruction and helps the trainer create appropriate training. (DS)

  17. The Systems Theory Framework of Career Development

    Science.gov (United States)

    McMahon, Mary

    2011-01-01

    The Systems Theory Framework (STF; McMahon & Patton, 1995; Patton & McMahon, 2006) of career development was proposed as a metatheoretical framework that accommodates the contribution of all theories and offers an integrative and coherent framework of career influences. In this article, the author provides an overview of the STF, outlines its…

  18. Developing a solar panel testing system

    Directory of Open Access Journals (Sweden)

    Árpád Rácz

    2009-10-01

    Full Text Available Solar energy is increasingly used togenerate electricity for individual households. There isa wide variety of solar panel technologies, whichshould be tested at an individual level during theirlifetime. In this paper, the development of a testingstation at the University of Debrecen is presented. Thetesting system can be used for research andeducational purposes and for in field applicationsequally well.

  19. Development of China Digital Seismological Observational Systems

    Institute of Scientific and Technical Information of China (English)

    刘瑞丰; 吴忠良; 阴朝民; 陈运泰; 庄灿涛

    2003-01-01

    Development of China Digital Seismological Observational Systems during 1996~2000 and the Capital Circle Area Seismograph Network during 1999~2001 are introduced, and the station distributions, instruments used, main tasks of National Digital Seismograph Network, Regional Digital Seismograph Network and Portable Digital Seismograph Network are introduced chiefly.

  20. Developing aircraft photonic networks for airplane systems

    DEFF Research Database (Denmark)

    White, Henry J.; Brownjohn, Nick; Baptista, João;

    2013-01-01

    Achieving affordable high speed fiber optic communication networks for airplane systems has proved to be challenging. In this paper we describe a summary of the EU Framework 7 project DAPHNE (Developing Aircraft Photonic Networks). DAPHNE aimed to exploit photonic technology from terrestrial comm...

  1. MPACT Fast Neutron Multiplicity System Prototype Development

    Energy Technology Data Exchange (ETDEWEB)

    D.L. Chichester; S.A. Pozzi; J.L. Dolan; M.T. Kinlaw; S.J. Thompson; A.C. Kaplan; M. Flaska; A. Enqvist; J.T. Johnson; S.M. Watson

    2013-09-01

    This document serves as both an FY2103 End-of-Year and End-of-Project report on efforts that resulted in the design of a prototype fast neutron multiplicity counter leveraged upon the findings of previous project efforts. The prototype design includes 32 liquid scintillator detectors with cubic volumes 7.62 cm in dimension configured into 4 stacked rings of 8 detectors. Detector signal collection for the system is handled with a pair of Struck Innovative Systeme 16-channel digitizers controlled by in-house developed software with built-in multiplicity analysis algorithms. Initial testing and familiarization of the currently obtained prototype components is underway, however full prototype construction is required for further optimization. Monte Carlo models of the prototype system were performed to estimate die-away and efficiency values. Analysis of these models resulted in the development of a software package capable of determining the effects of nearest-neighbor rejection methods for elimination of detector cross talk. A parameter study was performed using previously developed analytical methods for the estimation of assay mass variance for use as a figure-of-merit for system performance. A software package was developed to automate these calculations and ensure accuracy. The results of the parameter study show that the prototype fast neutron multiplicity counter design is very nearly optimized under the restraints of the parameter space.

  2. Development of a seasonal thermochemical storage system

    NARCIS (Netherlands)

    Cuypers, R.; Maraz, N.; Eversdijk, J.; Finck, C.J.; Henquet, E.M.P.; Oversloot, H.P.; Spijker, J.C. van 't; Geus, A.C. de

    2012-01-01

    In our laboratories, a seasonal thermochemical storage system for dwellings and offices is being designed and developed. Based on a thermochemical sorption reaction, space heating, cooling and generation of domestic hot water will be achieved with up to 100% renewable energy, by using solar energy a

  3. Dynamics of mononuclear phagocyte system Fc receptor function in systemic lupus erythematosus. Relation to disease activity and circulating immune complexes.

    Science.gov (United States)

    Kimberly, R P; Parris, T M; Inman, R D; McDougal, J S

    1983-02-01

    Seventeen pairs of longitudinal studies of mononuclear phagocyte system (MPS) Fc receptor function in 15 patients with systemic lupus were performed to explore the dynamic range of Fc receptor dysfunction in lupus and to establish the relationships between MPS function, clinical disease activity and circulating immune complexes (CIC). Fc receptor function was measured by the clearance of IgG sensitized autologous erythrocytes. At the time of first study the degree of MPS dysfunction was correlated with both clinical activity (P less than 0.05) and CIC (P less than 0.05). At follow-up patients with a change in clinical status show significantly larger changes in clearance function compared to clinically stable patients (206 min vs 7 min; P less than 0.001). MPS function changed concordantly with a change in clinical status in all cases (P = 0.002). Longitudinal assessments did not demonstrate concordance of changes in MPS function and CIC, measured by three different assays. The MPS Fc receptor defect in systemic lupus is dynamic and closely associated with disease activity. The lack of concordance of the defect with changes in CIC suggests that either CIC does not adequately reflect receptor site saturation or that other factors may also contribute to the magnitude of MPS dysfunction. PMID:6839542

  4. Development of Arduino based wireless control system

    Science.gov (United States)

    Sun, Zhuoxiong; Dyke, Shirley J.; Pena, Francisco; Wilbee, Alana

    2015-03-01

    Over the past few decades, considerable attention has been given to structural control systems to mitigate structural vibration under natural hazards such as earthquakes and extreme weather conditions. Traditional wired structural control systems often employ a large amount of cables for communication among sensors, controllers and actuators. In such systems, implementation of wired sensors is usually quite complicated and expensive, especially on large scale structures such as bridges and buildings. To reduce the laborious installation and maintenance cost, wireless control systems (WCSs) are considered as a novel approach for structural vibration control. In this work, a WCS is developed based on the open source Arduino platform. Low cost, low power wireless sensing and communication components are built on the Arduino platform. Structural control algorithms are embedded within the wireless sensor board for feedback control. The developed WCS is first validated through a series of tests. Next, numerical simulations are performed simulating wireless control of a 3-story shear structure equipped with a semi-active control device (MR damper). Finally, experimental studies are carried out implementing the WCS on the 3-story shear structure in the Intelligent Infrastructure Systems Lab (IISL). A hydraulic shake table is used to generate seismic ground motions. The control performance is evaluated with the impact of modeling uncertainties, measurement noises as well as time delay and data loss induced by the wireless network. The developed WCS is shown to be effective in controlling structural vibrations under several historical earthquake ground motions.

  5. Advanced Turbine Systems Program industrial system concept development

    Energy Technology Data Exchange (ETDEWEB)

    Gates, S. [Solar Turbines Inc., San Diego, CA (United States)

    1995-10-01

    The objective of Phase II of the Advanced Turbine Systems Program is to develop conceptual designs of gas fired advanced turbine systems that can be adapted for operation on coal and biomass fuels. The technical, economic, and environmental performance operating on natural gas and in a coal fueled mode is to be assessed. Detailed designs and test work relating to critical components are to be completed and a market study is to be conducted.

  6. Advanced CIDI Emission Control System Development

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, Christine

    2006-05-31

    Ford Motor Company, with ExxonMobil and FEV, participated in the Department of Energy's (DOE) Ultra-Clean Transportation Fuels Program with the goal to develop an innovative emission control system for light-duty diesel vehicles. The focus on diesel engine emissions was a direct result of the improved volumetric fuel economy (up to 50%) and lower CO2 emissions (up to 25%) over comparable gasoline engines shown in Europe. Selective Catalytic Reduction (SCR) with aqueous urea as the NOx reductant and a Catalyzed Diesel Particulate Filter (CDPF) were chosen as the primary emission control system components. The program expected to demonstrate more than 90% durable reduction in particulate matter (PM) and NOx emissions on a light-duty truck application, based on the FTP-75 drive cycle. Very low sulfur diesel fuel (<15 ppm-wt) enabled lower PM emissions, reduced fuel economy penalty due to the emission control system and improved long-term system durability. Significant progress was made toward a durable system to meet Tier 2 Bin 5 emission standards on a 6000 lbs light-duty truck. A 40% reduction in engine-out NOx emissions was achieved with a mid-size prototype diesel engine through engine recalibration and increased exhaust gas recirculation. Use of a rapid warm-up strategy and urea SCR provided over 90% further NOx reduction while the CDPF reduced tailpipe PM to gasoline vehicle levels. Development work was conducted to separately improve urea SCR and CDPF system durability, as well as improved oxidation catalyst function. Exhaust gas NOx and ammonia sensors were also developed further. While the final emission control system did not meet Tier 2 Bin 5 NOx after 120k mi of aging on the dynamometer, it did meet the standards for HC, NMOG, and PM, and an improved SCR catalyst was shown to have potential to meet the NOx standard, assuming the DOC durability could be improved further. Models of DOC and SCR function were developed to guide the study of several key

  7. Development of technical information processing systems

    International Nuclear Information System (INIS)

    The major goal of this project is to develop a more efficient information management system by connecting the KAREI serials database which enable the users to access from their own laboratory facilities through KAREI-NET. The importance of this project is to make the serials information of KAERI easily accessible to users as valuable resources for R and D activities. The results of the project are as follows. 1) Development of the serials database and retrieval system enabled us to access to the serials holding information through KAERI-NET. 2) The database construction establishes a foundation for the management of 1,600 serials held in KAERI. 3) The system can be applied not only to KAERI but also to similar medium-level libraries. (Author)

  8. Development of industrial variant specification systems

    DEFF Research Database (Denmark)

    Hansen, Benjamin Loer

    acquisition and order fulfilment, i.e. the creation of drawings, bill-of-materials, routings, product descriptions, quote letters etc. The present thesis is rooted in the assumption that variant specification systems supporting the cross-functional processes of order acquisition and order fulfilment must...... be developed from a holistic and strategically anchored point of view. Another assumption is that this is a challenge for many industrial companies. Even though the literature presents many considerations on general issues covering new information technology, little work is found on the business perspectives...... to the four research tasks of the Ph.D. project: • Define and describe the variant specification system. • Create a procedure for the development of variant specification systems. • Create concepts, methods and tools to support the analysis and determination of the variant specification task. • Identify...

  9. Solid oxide fuel cell power system development

    Energy Technology Data Exchange (ETDEWEB)

    Kerr, Rick [Delphi Automotive Systems, LLC., Troy, MI (United States); Wall, Mark [Independent Energy Partners Technology, LLC., Parker, CO (United States); Sullivan, Neal [Colorado School of Mines, Golden, CO (United States)

    2015-06-26

    This report summarizes the progress made during this contractual period in achieving the goal of developing the solid oxide fuel cell (SOFC) cell and stack technology to be suitable for use in highly-efficient, economically-competitive, commercially deployed electrical power systems. Progress was made in further understanding cell and stack degradation mechanisms in order to increase stack reliability toward achieving a 4+ year lifetime, in cost reduction developments to meet the SECA stack cost target of $175/kW (in 2007 dollars), and in operating the SOFC technology in a multi-stack system in a real-world environment to understand the requirements for reliably designing and operating a large, stationary power system.

  10. Development of radiation detection and measurement systems

    International Nuclear Information System (INIS)

    This report contains descriptions on the following six items. The first item is the result of a study on CsI(TI) crystals with their light emitting characteristics and the result of a study on plastic scintillators. The second item is the result of a study on advanced radiation detectors and includes experiments for the effect of using a Compton suppressor with an HPGe detector. For the third item, we describe the results of a design work done using EGS4 for a thickness gauge, a density gauge, and a level gauge. The fourth item contains descriptions on the prototype circuit systems developed for a level gauge, a thickness gauge, and for a survey meter. The fifth part contains the computed tomography algorithm and a prototype scanning system developed for a CT system. As the sixth and the last item, we describe the prototype high precision heat source and the prototype heat-voltage converter which we have designed and fabricated

  11. Development of radiation detection and measurement systems

    Energy Technology Data Exchange (ETDEWEB)

    Moon, B. S.; Ham, C. S.; Chung, C. E. and others

    2000-03-01

    This report contains descriptions on the following six items. The first item is the result of a study on CsI(TI) crystals with their light emitting characteristics and the result of a study on plastic scintillators. The second item is the result of a study on advanced radiation detectors and includes experiments for the effect of using a Compton suppressor with an HPGe detector. For the third item, we describe the results of a design work done using EGS4 for a thickness gauge, a density gauge, and a level gauge. The fourth item contains descriptions on the prototype circuit systems developed for a level gauge, a thickness gauge, and for a survey meter. The fifth part contains the computed tomography algorithm and a prototype scanning system developed for a CT system. As the sixth and the last item, we describe the prototype high precision heat source and the prototype heat-voltage converter which we have designed and fabricated.

  12. Controls system developments for the ERL facility

    Energy Technology Data Exchange (ETDEWEB)

    Jamilkowski, J.; Altinbas, Z.; Gassner, D.; Hoff, L.; Kankiya, P.; Kayran, D.; Miller, T.; Olsen, R.; Sheehy, B.; Xu, W.

    2011-10-07

    The BNL Energy Recovery LINAC (ERL) is a high beam current, superconducting RF electron accelerator that is being commissioned to serve as a research and development prototype for a RHIC facility upgrade for electron-ion collision (eRHIC). Key components of the machine include a laser, photocathode, and 5-cell superconducting RF cavity operating at a frequency of 703 MHz. Starting with a foundation based on existing ADO software running on Linux servers and on the VME/VxWorks platforms developed for RHIC, we are developing a controls system that incorporates a wide range of hardware I/O interfaces that are needed for machine R&D. Details of the system layout, specifications, and user interfaces are provided.

  13. Development of vehicle intelligent monitoring system (VIMS)

    Science.gov (United States)

    Fujino, Yozo; Kitagawa, Keisuke; Furukawa, Takashi; Ishii, Hironori

    2005-05-01

    In an urban highway network system such as Tokyo Metropolitan Expressway, to detect conditions of road pavement and expansion joints is a very important issue. Although accurate surface condition can be captured by using a road profiler system, the operating cost is expensive and development of a simpler and more inexpensive system is really needed to reduce monitoring cost. "Vehicle Intelligent Monitoring System (VIMS)" developed for this purpose is described in this paper. An accelerometer and GPS are installed to an ordinary road patrol car. GPS together with a PC computer are used to measure the road surface condition and to identify the location of the vehicle, respectively. Dynamic response of the vehicle is used as a measure of the road pavements surface condition as well as the expansion joints. A prototype of VIMS is installed to a motor car and measurement is made at the actual roads. Accuracy of measuring result and effectiveness of this system are demonstrated; the outline of the system and some of the measurement results are reported herein.

  14. Development of an Integrated Distribution Management System

    Energy Technology Data Exchange (ETDEWEB)

    Schatz, Joe E.

    2010-10-20

    This final report details the components, functionality, costs, schedule and benefits of developing an Integrated Distribution Management System (IDMS) for power distribution system operation. The Distribution Automation (DA) and Supervisory Control and Data Acquisition (SCADA) systems used by electric power companies to manage the distribution of electric power to retail energy consumers are vital components of the Nation’s critical infrastructure. Providing electricity is an essential public service and a disruption in that service, if not quickly restored, could threaten the public safety and the Nation’s economic security. Our Nation’s economic prosperity and quality of life have long depended on the essential services that utilities provide; therefore, it is necessary to ensure that electric utilities are able to conduct their operations safely and efficiently. A fully integrated technology of applications is needed to link various remote sensing, communications and control devices with other information tools that help guide Power Distribution Operations personnel. A fully implemented IDMS will provide this, a seamlessly integrated set of applications to raise electric system operating intelligence. IDMS will enhance DA and SCADA through integration of applications such as Geographic Information Systems, Outage Management Systems, Switching Management and Analysis, Operator Training Simulator, and other Advanced Applications, including unbalanced load flow and fault isolation/service restoration. These apps are capable of utilizing and obtaining information from appropriately installed DER, and by integrating disparate systems, the Distribution Operators will benefit from advanced capabilities when analyzing, controlling and operating the electric system.

  15. J-2X Abort System Development

    Science.gov (United States)

    Santi, Louis M.; Butas, John P.; Aguilar, Robert B.; Sowers, Thomas S.

    2008-01-01

    The J-2X is an expendable liquid hydrogen (LH2)/liquid oxygen (LOX) gas generator cycle rocket engine that is currently being designed as the primary upper stage propulsion element for the new NASA Ares vehicle family. The J-2X engine will contain abort logic that functions as an integral component of the Ares vehicle abort system. This system is responsible for detecting and responding to conditions indicative of impending Loss of Mission (LOM), Loss of Vehicle (LOV), and/or catastrophic Loss of Crew (LOC) failure events. As an earth orbit ascent phase engine, the J-2X is a high power density propulsion element with non-negligible risk of fast propagation rate failures that can quickly lead to LOM, LOV, and/or LOC events. Aggressive reliability requirements for manned Ares missions and the risk of fast propagating J-2X failures dictate the need for on-engine abort condition monitoring and autonomous response capability as well as traditional abort agents such as the vehicle computer, flight crew, and ground control not located on the engine. This paper describes the baseline J-2X abort subsystem concept of operations, as well as the development process for this subsystem. A strategy that leverages heritage system experience and responds to an evolving engine design as well as J-2X specific test data to support abort system development is described. The utilization of performance and failure simulation models to support abort system sensor selection, failure detectability and discrimination studies, decision threshold definition, and abort system performance verification and validation is outlined. The basis for abort false positive and false negative performance constraints is described. Development challenges associated with information shortfalls in the design cycle, abort condition coverage and response assessment, engine-vehicle interface definition, and abort system performance verification and validation are also discussed.

  16. Developing 360 degree feedback system for KINS

    Energy Technology Data Exchange (ETDEWEB)

    Han, In Soo; Cheon, B. M.; Kim, T. H.; Ryu, J. H. [Chungman National Univ., Daejeon (Korea, Republic of)

    2003-12-15

    This project aims to investigate the feasibility of a 360 degree feedback systems for KINS and to design guiding rules and structures in implementing that systems. Literature survey, environmental analysis and questionnaire survey were made to ensure that 360 degree feedback is the right tool to improve performance in KINS. That review leads to conclusion that more readiness and careful feasibility review are needed before implementation of 360 degree feedback in KINS. Further the project suggests some guiding rules that can be helpful for successful implementation of that system in KINS. Those include : start with development, experiment with one department, tie it to a clear organization's goal, train everyone involve, make sure to try that system in an atmosphere of trust.

  17. IDEAL: A methology for developing information systems

    Science.gov (United States)

    Evers, Ken H.; Bachert, Robert F.

    1988-01-01

    As a result of improved capabilities obtained through current computer technologies, application programs and expert systems, Enterprises are being designed or upgraded to be highly integrated and automated information systems. To design or modify Enterprises, it is necessary to first define what functions are to be performed within the Enterprise, identify which functions are potential candidates for automation, and what automated or expert systems are available, or must be developed, to accomplish the selected function. Second, it is necessary to define and analyze the informational requirements for each function along with the informational relationships among the functions so that a database structure can be established to support the Enterprise. To perform this type of system design, an integrated set of analysis tools is required to support the information analysis process. The IDEAL (Integrated Design and Engineering Analysis Languages) methodology provides this integrated set of tools and is discussed.

  18. APS storage ring vacuum system development

    International Nuclear Information System (INIS)

    The Advanced Photon Source synchrotron radiation facility, under construction at the Argonne National Laboratory, incorporates a large ring for the storage of 7 GeV positrons for the generation of photon beams for the facility's materials research program. The Storage Ring's 1104 m circumference is divided into 40 sectors which contain vacuum, beam transport, control, rf and insertion device systems. The vacuum system will operate at a pressure of 1 nTorr and is fabricated from aluminum. The system includes distributed NeG pumping, photon absorbers with lumped pumping, beam position monitors, vacuum diagnostics and valving. An overview of the vacuum system design and details of selected development program results are presented. 5 refs

  19. MPS/CAS Partner Group on Plant Molecular Physiology and Signal Transduction

    Institute of Scientific and Technical Information of China (English)

    Xue Hongwei; Lothar Willmitzer

    2004-01-01

    @@ Rice is mankind's most important food crop - the staple diet for half of the world's population - and is also tremendously important for Chinese food production.Hence, understanding how rice grows and interacts with its environment, which often adversely affects plant development and crop yield, is of prime importance.

  20. HELIAS module development for systems codes

    Energy Technology Data Exchange (ETDEWEB)

    Warmer, F., E-mail: Felix.Warmer@ipp.mpg.de; Beidler, C.D.; Dinklage, A.; Egorov, K.; Feng, Y.; Geiger, J.; Schauer, F.; Turkin, Y.; Wolf, R.; Xanthopoulos, P.

    2015-02-15

    In order to study and design next-step fusion devices such as DEMO, comprehensive systems codes are commonly employed. In this work HELIAS-specific models are proposed which are designed to be compatible with systems codes. The subsequently developed models include: a geometry model based on Fourier coefficients which can represent the complex 3-D plasma shape, a basic island divertor model which assumes diffusive cross-field transport and high radiation at the X-point, and a coil model which combines scaling aspects based on the HELIAS 5-B reactor design in combination with analytic inductance and field calculations. In addition, stellarator-specific plasma transport is discussed. A strategy is proposed which employs a predictive confinement time scaling derived from 1-D neoclassical and 3-D turbulence simulations. This paper reports on the progress of the development of the stellarator-specific models while an implementation and verification study within an existing systems code will be presented in a separate work. This approach is investigated to ultimately allow one to conduct stellarator system studies, develop design points of HELIAS burning plasma devices, and to facilitate a direct comparison between tokamak and stellarator DEMO and power plant designs.

  1. Development of multifunctional energy systems (MESs)

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Ruixian; Jin, Hongguang; Gao, Lin; Hong, Hui [Institute of Engineering Thermophysics, Chinese Academy of Sciences, P.O. Box 2706, Beijing 100080 (China)

    2010-11-15

    By synthetically combining the utilization of different fuels and the co-production of alternative fuels and power, a multifunctional energy system (MES) can present more opportunities to achieve higher efficiency, lower investment, and less environmental impact as compared to traditional energy systems. The principle for the integration of MES is systematically illuminated from the perspective of chemical conversion, energy utilization, and pollutants control. According to system integration characteristics, the development of MES has been classified into three stages, namely, polygeneration systems, MESs combining different fossil fuels, and MESs combining fossil fuel and renewable energy. Three MESs with primary energy savings (PESs) of 14-18% are introduced, which illustrated the potential of MES technology. At the same time, the increment of investment cost had been indicated as the major possible barriers for development of MES technology. On the basis of a comparison with other technical routes, super-critical power plants, and IGCC technology, the role of the MES in the sustainable development of China has been established. (author)

  2. Life support system development in West Germany

    Science.gov (United States)

    Skoog, A. Ingemar

    The delivery of fully qualified Environmental Control and Life Support System (ECLS) flight hardware for the Spacelab Flight Unit was completed in 1979, and the first Spacelab flight is scheduled for mid 1983. With Spacelab approaching its operational stage, ESA has initiated the Follow-on Development Programme. The future evolution of Spacelab elements in a continued U.S./European cooperation is obviously linked to the U.S. STS evolution and leads from the sortie-mode improvements (Initial Step) towards pallet systems and module applications in unmanned and manned space platforms (Medium and Far Term Alternatives). Extensive studies and design work have been accomplished on life support systems for Life Sciences Laboratories (Biorack) in Spacelab (incubators and holding units for low vertebrates). Future long term missions require the implementation of closed loop life support systems and in order to meet the long range development cycle feasibility studies have been performed. Terrestrial applications of the life support technologies developed for space have been successfully implemented.

  3. Offshore Wind Energy Systems Engineering Curriculum Development

    Energy Technology Data Exchange (ETDEWEB)

    McGowan, Jon G. [Univ. of Massachusetts, Amherst, MA (United States); Manwell, James F. [Univ. of Massachusetts, Amherst, MA (United States); Lackner, Matthew A. [Univ. of Massachusetts, Amherst, MA (United States)

    2012-12-31

    Utility-scale electricity produced from offshore wind farms has the potential to contribute significantly to the energy production of the United States. In order for the U.S. to rapidly develop these abundant resources, knowledgeable scientists and engineers with sound understanding of offshore wind energy systems are critical. This report summarizes the development of an upper-level engineering course in "Offshore Wind Energy Systems Engineering." This course is designed to provide students with a comprehensive knowledge of both the technical challenges of offshore wind energy and the practical regulatory, permitting, and planning aspects of developing offshore wind farms in the U.S. This course was offered on a pilot basis in 2011 at the University of Massachusetts and the National Renewable Energy Laboratory (NREL), TU Delft, and GL Garrad Hassan have reviewed its content. As summarized in this report, the course consists of 17 separate topic areas emphasizing appropriate engineering fundamentals as well as development, planning, and regulatory issues. In addition to the course summary, the report gives the details of a public Internet site where references and related course material can be obtained. This course will fill a pressing need for the education and training of the U.S. workforce in this critically important area. Fundamentally, this course will be unique due to two attributes: an emphasis on the engineering and technical aspects of offshore wind energy systems, and a focus on offshore wind energy issues specific to the United States.

  4. Requirements development for a patient computing system.

    Science.gov (United States)

    Wald, J S; Pedraza, L A; Reilly, C A; Murphy, M E; Kuperman, G J

    2001-01-01

    Critical parts of the software development life cycle are concerned with eliciting, understanding, and managing requirements. Though the literature on this subject dates back for several decades, practicing effective requirements development remains a current and challenging area. Some projects flourish with a requirements development process (RDP) that is implicit and informal, but this approach may be overly risky, particularly for large projects that involve multiple individuals, groups, and systems over time. At Partners HealthCare System in Boston, Massachusetts, we have applied a more formal approach for requirements development to the Patient Computing Project. The goal of the project is to create web-based software that connects patients electronically with their physician's offices and has the potential to improve care efficiency and quality. It is a large project, with over 500 function points. Like most technological innovation, the successful introduction of this system requires as much attention to understanding the business needs and workflow details as it does to technical design and implementation. This paper describes our RDP approach, and key business requirements discovered through this process. We believe that a formal RDP is essential, and that informatics as a field must include proficiencies in this area. PMID:11825282

  5. Development of the Medium Energy Linac Systems

    International Nuclear Information System (INIS)

    The main purpose of this project is developing 100-MeV proton linear accelerator (linac) for proton engineering frontier project (PEFP). In the first phase of the PEFP, the development of the 20-MeV linac has successfully finished. Hence the work scope of this project is designing the linac to accelerate proton beams from 20-MeV up to 100-MeV, fabricating the linac up to 45 MeV, fabricating one set of the medium energy beam transport (MEBT) tank, and developing the low level radio frequency (LLRF) system and the control system. The basic role of the new proton accelerator is accelerating 20-mA proton beams from 20 MeV up to 100 MeV. The first step of the design procedure is optimizing and determining the accelerator parameters. The beam loss is also main concern in the design stage. The drift tube (DT) and the quadrupole magnets are designed to be optimized to the new linac design. The other purpose is confirming the new design by fabricating and tuning the drift tube linac (DTL). The 20MeV proton beam divided into two directions. One is supplying the beams to user group by turning on the 45-degree bending magnet. The other is guided into the 100-MeV DTL by tuning off the dipole magnet. That is why the PEFP MEBT located after 20-MeV DTL. The MEBT is realized as two small DTL tanks with three cells and a 45-degree bending magnet. The fabrication of one MEBT tank is another purpose of this project. The other purposes of this project is developing the LLRF system to control the RF signal and control system to monitor and control the vacuum system, magnet power supply, etc

  6. Development of an inhalable, stimuli-responsive particulate system for delivery to deep lung tissue.

    Science.gov (United States)

    Abbas, Yasmine; Azzazy, Hassan M E; Tammam, Salma; Lamprecht, Alf; Ali, Mohamed Ehab; Schmidt, Annette; Sollazzo, Silvio; Mathur, Sanjay

    2016-10-01

    Lung cancer, the deadliest solid tumor among all types of cancer, remains difficult to treat. This is a result of unavoidable exposure to carcinogens, poor diagnosis, the lack of targeted drug delivery platforms and limitations associated with delivery of drug to deep lung tissues. Development of a non-invasive, patient-convenient formula for the targeted delivery of chemotherapeutics to cancer in deep lung tissue is the aim of this study. The formulation consisted of inhalable polyvinylpyrrolidone (PVP)/maltodextrin (MD)-based microparticles (MPs) encapsulating chitosan (CS) nanoparticles (NPs) loaded with either drug only or drug and magnetic nanoparticles (MNPs). Drug release from CS NPs was enhanced with the aid of MNPs by a factor of 1.7 in response to external magnetic field. Preferential toxicity by CS NPs was shown towards tumor cells (A549) in comparison to cultured fibroblasts (L929). The prepared spray freeze dried (SFD) powders for CS NPs and CS MNPs were of the same size at ∼6μm. They had a fine particle fraction (FPF≤5.2μm) of 40-42% w/w and mass median aerodynamic diameter (MMAD) of 5-6μm as determined by the Next Generation Impactor (NGI). SFD-MPs of CS MNPs possess higher MMAD due to the high density associated with encapsulated MNPs. The developed formulation demonstrates several capabilities including tissue targeting, controlled drug release, and the possible imaging and diagnostic values (due to its MNPs content) and therefore represents an improved therapeutic platform for drug delivery to cancer in deep lung tissue.

  7. ARM System Developer's Guide Designing and Optimizing System Software

    CERN Document Server

    Sloss, Andrew

    2004-01-01

    Over the last ten years, the ARM architecture has become one of the most pervasive architectures in the world, with more than 2 billion ARM-based processors embedded in products ranging from cell phones to automotive braking systems. A world-wide community of ARM developers in semiconductor and product design companies includes software developers, system designers and hardware engineers. To date no book has directly addressed their need to develop the system and software for an ARM-based system. This text fills that gap. This book provides a comprehensive description of the operation of the ARM core from a developer's perspective with a clear emphasis on software. It demonstrates not only how to write efficient ARM software in C and assembly but also how to optimize code. Example code throughout the book can be integrated into commercial products or used as templates to enable quick creation of productive software. The book covers both the ARM and Thumb instruction sets, covers Intel''s XScale Processors, ou...

  8. Development of evaluation system for flashing erosion

    International Nuclear Information System (INIS)

    Liquid droplet impingement erosion (LDI) is defined as an erosion phenomenon caused by high-speed droplet attack in a wet steam flow, and sometimes observed in a steam piping system of a power plant. In our previous researches, we have developed an LDI evaluation system to evaluate the thinning shape due to LDI on a steam piping within a practically acceptable time. However, present system is not applicable to LDI on a hot-water piping due to flashing phenomena (flashing erosion) because it is difficult to calculate the flashing flow due to sudden phase change and critical flow rate evaluation models needed for LDI evaluation system are not verified in wet steam region. Therefore, in this study, we tried to develop a new flow calculation code for flashing flow and to verify the critical flow rate evaluation models in wet steam region. For flashing flow simulation, based on a present CFD code, pre-conditioning method was adopted to achieve the stable calculation of the water region, and extended look-up table including from low-pressure water to high-pressure dry steam was incorporated. Finally, a new CFD code water-steam flow was developed. Several benchmark tests were conducted and those results show this new code can reproduce the flashing phenomena and is applicable from the very low-speed flow to supersonic flow. Then, HEM model for critical mass flow rate was verified with flashing and wet steam experiments and CFD calculations, and incorporated into LDI evaluation system to extend applicable region of the evaluation system into flashing erosion. (author)

  9. Systems strategies for developing industrial microbial strains.

    Science.gov (United States)

    Lee, Sang Yup; Kim, Hyun Uk

    2015-10-01

    Industrial strain development requires system-wide engineering and optimization of cellular metabolism while considering industrially relevant fermentation and recovery processes. It can be conceptualized as several strategies, which may be implemented in an iterative fashion and in different orders. The key challenges have been the time-, cost- and labor-intensive processes of strain development owing to the difficulties in understanding complex interactions among the metabolic, gene regulatory and signaling networks at the cell level, which are collectively represented as overall system performance under industrial fermentation conditions. These challenges can be overcome by taking systems approaches through the use of state-of-the-art tools of systems biology, synthetic biology and evolutionary engineering in the context of industrial bioprocess. Major systems metabolic engineering achievements in recent years include microbial production of amino acids (L-valine, L-threonine, L-lysine and L-arginine), bulk chemicals (1,4-butanediol, 1,4-diaminobutane, 1,5-diaminopentane, 1,3-propanediol, butanol, isobutanol and succinic acid) and drugs (artemisinin). PMID:26448090

  10. Equipment system for advanced nuclear fuel development

    International Nuclear Information System (INIS)

    The purpose of the settlement of equipment system for nuclear Fuel Technology Development Facility(FTDF) is to build a seismic designed facility that can accommodate handling of nuclear materials including <20% enriched Uranium and produce HANARO fuel commercially, and also to establish the advanced common research equipment essential for the research on advanced fuel development. For this purpose, this research works were performed for the settlement of radiation protection system and facility special equipment for the FTDF, and the advanced common research equipment for the fuel fabrication and research. As a result, 11 kinds of radiation protection systems such as criticality detection and alarm system, 5 kinds of facility special equipment such as environmental pollution protection system and 5 kinds of common research equipment such as electron-beam welding machine were established. By the settlement of exclusive domestic facility for the research of advanced fuel, the fabrication and supply of HANARO fuel is possible and also can export KAERI-invented centrifugal dispersion fuel materials and its technology to the nations having research reactors in operation. For the future, the utilization of the facility will be expanded to universities, industries and other research institutes

  11. Maximum Potential Score (MPS): An operating model for a successful customer-focused strategy.

    OpenAIRE

    Cabello González, José Manuel; Galguera, Laura; Ruiz de la Rúa, Francisco

    2015-01-01

    One of marketers’ chief objectives is to achieve customer loyalty, which is a key factor for profitable growth. Therefore, they need to develop a strategy that attracts and maintains customers, giving them adequate motives, both tangible (prices and promotions) and intangible (personalized service and treatment), to satisfy a customer and make him loyal to the company. Finding a way to accurately measure satisfaction and customer loyalty is very important. With regard to typical Relationship ...

  12. [Development of Hospital Equipment Maintenance Information System].

    Science.gov (United States)

    Zhou, Zhixin

    2015-11-01

    Hospital equipment maintenance information system plays an important role in improving medical treatment quality and efficiency. By requirement analysis of hospital equipment maintenance, the system function diagram is drawed. According to analysis of input and output data, tables and reports in connection with equipment maintenance process, relationships between entity and attribute is found out, and E-R diagram is drawed and relational database table is established. Software development should meet actual process requirement of maintenance and have a friendly user interface and flexible operation. The software can analyze failure cause by statistical analysis. PMID:27066680

  13. Scaling Health Information Systems in Developing Countries

    DEFF Research Database (Denmark)

    Mengiste, Shegaw Anagaw; Neilsen, Petter

    2006-01-01

    specifically, we question the fruitfulness of focusing on not being installed base hostile and suggest focusing on how to be installed base “friendly” by underscoring how the installed base can also be draw upon and shaped by human agents. The paper conceptualizes health information infrastructure (HII......This article addresses the issues of scaling health information system in the context of developing countries by taking a case study from Ethiopia. Concepts of information infrastructure have been used as an analytical lens to better understand scaling of Health Information systems. More...

  14. Space Launch System Accelerated Booster Development Cycle

    Science.gov (United States)

    Arockiam, Nicole; Whittecar, William; Edwards, Stephen

    2012-01-01

    With the retirement of the Space Shuttle, NASA is seeking to reinvigorate the national space program and recapture the public s interest in human space exploration by developing missions to the Moon, near-earth asteroids, Lagrange points, Mars, and beyond. The would-be successor to the Space Shuttle, NASA s Constellation Program, planned to take humans back to the Moon by 2020, but due to budgetary constraints was cancelled in 2010 in search of a more "affordable, sustainable, and realistic" concept2. Following a number of studies, the much anticipated Space Launch System (SLS) was unveiled in September of 2011. The SLS core architecture consists of a cryogenic first stage with five Space Shuttle Main Engines (SSMEs), and a cryogenic second stage using a new J-2X engine3. The baseline configuration employs two 5-segment solid rocket boosters to achieve a 70 metric ton payload capability, but a new, more capable booster system will be required to attain the goal of 130 metric tons to orbit. To this end, NASA s Marshall Space Flight Center recently released a NASA Research Announcement (NRA) entitled "Space Launch System (SLS) Advanced Booster Engineering Demonstration and/or Risk Reduction." The increased emphasis on affordability is evident in the language used in the NRA, which is focused on risk reduction "leading to an affordable Advanced Booster that meets the evolved capabilities of SLS" and "enabling competition" to "enhance SLS affordability. The purpose of the work presented in this paper is to perform an independent assessment of the elements that make up an affordable and realistic path forward for the SLS booster system, utilizing advanced design methods and technology evaluation techniques. The goal is to identify elements that will enable a more sustainable development program by exploring the trade space of heavy lift booster systems and focusing on affordability, operability, and reliability at the system and subsystem levels5. For this study

  15. Towards a Provotyping Approach in Systems Development

    DEFF Research Database (Denmark)

    Mogensen, Preben Holst

    1992-01-01

    concrete experience is developed through an investigation of prototyping and activity theory. Exploration of this notion leads to the idea of the systemdeveloper ‘provoking ’ concrete, everyday practice, by exposing current problems, calling forth what usually is taken for granted. Problems with current...... the twofold purpose of contextualizing the new ideas as well as developing techniques for carrying themout.......This paper explores the notion of ‘provocation through concrete experience’ towards a provotyping approach. It addresses the question: How do we on the one hand, devise qualitatively new systems, and on the other hand, ensure their usability in a given practice? The notion of provocation through...

  16. A Guerilla Approach to Control System Development

    CERN Document Server

    Dovc, J; Plesko, M

    2001-01-01

    We present our experiences in managing the development cycles of the control systems for ANKA and the ALMA Common Software. Our team consists practically only of undergraduate students. Stimulating and rewarding the students with cutting-edge technologies and travel to conferences like this and installation fieldwork are an important positive factor in raising their motivation. However, building any system with a group of inexperienced students is quite a challenging task. Many problems occur with planning deadlines and missing them, organizing and managing development, sources, and documentation and also when dealing with conventional program management rules. To cope with them, we use many tools: CVS for versioning and source archiving, Bugzilla for keeping our bugs in order, a to-do list for managing tasks, an activity log and also many other programs and scripts, some found on the Internet and some made by ourselves. In the end, we had to become organized like a professional company. Documentation and dem...

  17. Development of NMCA system and software

    International Nuclear Information System (INIS)

    Full text: Development of the NMCA system in the Institute of Atomic Energy is described. The Institute is the one of research scientific subdivisions of the National Nuclear Center of the Republic of Kazakhstan. Four nuclear facilities in the country is operating. Institute is a facility with two research reactors, located on the remote sites of the former Semipalatinsk nuclear test site. Layouts and main parameters of the reactors are attached. In additional to reactors, NM storages, on-pile stands, research labs and hot cell are located on sites. The NM storing and handling are covered by NMCA system which after USSR disintegration was in a bad condition: on-paper account, lack of personal training, normative documents, measuring system, and access control. After ratification of Safeguards Agreement all Kazakhstan's nuclear facilities became to being inspected by IAEA and State authority. Putting of the NMCA system according to international rules is started. Since 1993 a collaboration with Departments of Defense and Energy is begun, particularly with Los-Alamos, Sandia and Oak-Ridge National labs. Directions of development and needs of technical and methodical assistance were defined. In the following time a computers for account, spectrometric and weighing equipment for NDA, TID and other office equipment were delivered. Development of a number of documents concerning regulation of NM handling, IAEA inspectors cooperation, reporting was conducted under ORNL support. NMCA custodians were participants of many training courses held in Kazakhstan, NIS, LANL, NRC. The computerized NMCA system 'AIMAS' developed in ANL and delivered to the Institute was implemented successfully in 1995. During some followed years the 'AIMAS' system was modified step by step and spread to other nuclear facilities of Kazakhstan and Uzbekistan under DOE support. The important element of supporting of SSAC development in Kazakhstan is funding and providing with methodic of annual

  18. Recent developments in affective recommender systems

    Science.gov (United States)

    Katarya, Rahul; Verma, Om Prakash

    2016-11-01

    Recommender systems (RSs) are playing a significant role since 1990s as they provide relevant, personalized information to the users over the internet. Lots of work have been done in information filtering, utilization, and application related to RS. However, an important area recently draws our attention which is affective recommender system. Affective recommender system (ARS) is latest trending area of research, as publication in this domain are few and recently published. ARS is associated with human behaviour, human factors, mood, senses, emotions, facial expressions, body gesture and physiological with human-computer interaction (HCI). Due to this assortment and various interests, more explanation is required, as it is in premature phase and growing as compared to other fields. So we have done literature review (LR) in the affective recommender systems by doing classification, incorporate reputed articles published from the year 2003 to February 2016. We include articles which highlight, analyse, and perform a study on affective recommender systems. This article categorizes, synthesizes, and discusses the research and development in ARS. We have classified and managed ARS papers according to different perspectives: research gaps, nature, algorithm or method adopted, datasets, the platform on executed, types of information and evaluation techniques applied. The researchers and professionals will positively support this survey article for understanding the current position, research in affective recommender systems and will guide future trends, opportunity and research focus in ARS.

  19. Developing digital control for aquaponic system

    OpenAIRE

    REPŠE, MATIC

    2015-01-01

    The goal of the thesis is to show the development and implementation process of hardware and software solution for controlling and managing Aquaponics systems, which are responsible for simultaneous production of animal protein (fish) and plants. In the thesis, we described what Aquaponics consists of, where is our attention mostly needed and the problems we have to deal with. We also added a short explanation of the possible corresponding approach to a solution. Hereafter, we presented ou...

  20. Development of cask and transportation system

    International Nuclear Information System (INIS)

    Transportation of spent fuels to the AFR interim storage facility and disposal repository are necessary in Korea. Therefore, an emphasis has been concentrated to develop the design and fabrication technology of commercial casks. A conceptual design of the temperature and deformation measuring systems in the cask, which will be used for mock-up tests has been performed. Preliminary design data of the cask for 7 spent PWR fuels have been obtained in the course of study. (author)

  1. Breeder reactor fuel fabrication system development

    International Nuclear Information System (INIS)

    Significant progress has been made in the design and development of remotely operated breeder reactor fuel fabrication and support systems (e.g., analytical chemistry). These activities are focused by the Secure Automated Fabrication (SAF) Program sponsored by the Department of Energy to provide: a reliable supply of fuel pins to support US liquid metal cooled breeder reactors and at the same time demonstrate the fabrication of mixed uranium/plutonium fuel by remotely operated and automated methods

  2. Developing innovative systems for reinforced masonry walls

    OpenAIRE

    Mosele, F.; Porto, F. da; Modena, C.; Fusco, A. di; Cesare, G. di; Vasconcelos, Graça; Haach, V.; Lourenço, Paulo B.; Beer, I; Schmidt, U.; Brameshuber, W.; Scheufler, W.; Schermer, D. C.; Zilch, K.

    2006-01-01

    The Commission of the European Communities has recently funded a CRAFT research project aimed at developing innovative systems for load and non-load-bearing reinforced masonry walls. The project involves twelve partners coming from four different European countries, among which there are universities and research centres, small and medium enterprises for the production of clay and concrete units and mortars, a company for advanced metal products and industrial associations of brick and block ...

  3. Emergence of order in visual system development.

    Science.gov (United States)

    Shatz, C J

    1996-01-01

    Neural connections in the adult central nervous system are highly precise. In the visual system, retinal ganglion cells send their axons to target neurons in the lateral geniculate nucleus (LGN) in such a way that axons originating from the two eyes terminate in adjacent but non-overlapping eye-specific layers. During development, however, inputs from the two eyes are intermixed, and the adult pattern emerges gradually as axons from the two eyes sort out to form the layers. Experiments indicate that the sorting out process, even though it occurs in utero in higher mammals and always before vision, requires retinal ganglion cell signaling: blocking retinal ganglion cell action potentials with tetrodotoxin prevents the formation of the layers. These action potentials are endogenously generated by the ganglion cells, which fire spontaneously and synchronously with each other, generating 'waves' of activity that travel across the retina. Calcium imaging of the retina shows that the ganglion cells undergo correlated calcium bursting to generate the waves, and that amacrine cells also participate in the correlated activity patterns. Physiological recordings from LGN neurons in vitro indicate that the quasi-periodic activity generated by the retinal ganglion cells is transmitted across the synapse between ganglion cells to drive target LGN neurons. These observations suggest that: 1) a neural circuit within the immature retina is responsible for generating specific spatiotemporal patterns of neural activity: 2) spontaneous activity generated in the retina is propagated across central synapses; and 3) even before the photoreceptors are present, nerve cell function is essential for correct wiring of the visual system during early development. Since spontaneously generated activity is known to be present elsewhere in the developing central nervous system (CNS), this process of activity-dependent wiring could be used throughout the nervous system to help refine early sets of

  4. Development of the NLTSS operating system

    Energy Technology Data Exchange (ETDEWEB)

    Du Bois, P.J.

    1984-06-01

    The NLTSS implementation effort has been going on for some five years now. Many parts of the system have been running for several years, but are undergoing constant change. There are three areas to consider. First, the distributable network operating system and communications protocols require a careful study of requirements and goals. The development of the LINCS architecture in concert with the perceived structure of the NLTSS message system and servers was a complex social process in which we all had to learn the give and take of negotiation. Reaching consensus agreements was often a lengthy and uncomfortable process. Then choosing the algorithms for implementation and developing them in a network environment is complicated. Secondly, the implementation effort itself was complicated by the use of new programming techniques, e.g., use of the MODEL language, the design for co-servers. Determining efficient mechanisms for communication and input/output in a message passing network architecture takes time. Oftentimes, special case optimizations would be implemented too quickly. There was and still is a lot of try, learn, try again technique employed in the development of NLTSS and LINCS. In the beginning of the project all the various support tools were yet to be conceived and implemented. These actually represent a major portion of the first couple of years' work.

  5. NWAS. Developments for passive uranium assay system

    International Nuclear Information System (INIS)

    We developed uranium mass assay systems for 200-litter wastes drums applied neutron and gamma measurements by NDA method. The systems are composed of the 16 pieces of Helium-3 proportional counters for neutron detection with 100mm thickness polyethylene and a Ge-SSD for gamma ray detection. The neutron measurement methodology is consist of U-234 (α,n) reaction and gamma measurement is applied by Ge-SSD. The extensive testing trials using the known amount of uranium with different enrichment and some kinds of matrices in drums were performed. By using this system we tried to determine uranium mass in drums for the purpose of reduction MUF in URCP. (author)

  6. Development of the environmental neutron detection system

    CERN Document Server

    Kume, K

    2002-01-01

    Environmental neutron detection system was proposed and developed. The main goal of this system was set to detect fast and thermal neutrons with the identical detectors setup without degraders. This system consists of a sup 1 sup 0 B doped liquid scintillator for n detection and CsI scintillators for simultaneous gamma emission from sup 1 sup 0 B doped in the liquid scintillator after the n capture reaction. The first setup was optimized for the thermal n detection, while the second setup was for the fast n detection. It was shown that the thermal n flux was obtained in the first setup by using the method of the gamma coincidence method with the help of the Monte Carlo calculation. The second setup was designed to improve the detection efficiency for the fast n, and was shown qualitatively that both the pulse shape discrimination and the coincidence methods are efficient. There will be more improvements, particularly for the quantitative discussion.

  7. Developing sustainable systems for nematode management.

    Science.gov (United States)

    Barker, K R; Koenning, S R

    1998-01-01

    Early researchers identified key concepts and developed tactics for multiple-option management of nematodes. Although the emphasis on integrated pest management over the past three decades has promoted strategies and tactics for nematode management, comprehensive studies on the related soil biology-ecology are relatively recent. Traditional management tactics include host resistance (where available), cultural tactics such as rotation with nonhosts, sanitation and avoidance, and destruction of residual crop roots, and the judicious use of nematicides. There have been advances in biological control of nematodes, but field-scale exploitation of this tactic remains to be realized. New technologies and resources are currently becoming central to the development of sustainable systems for nematode-pest-crop management: molecular diagnostics for nematode identification, genetic engineering for host resistance, and the elucidation and application of soil biology for general integrated cropping systems. The latter strategy includes the use of nematode-pest antagonistic cover crops, animal wastes, and limited tillage practices that favor growth-promoting rhizobacteria, earthworms, predatory mites, and other beneficial organisms while suppressing parasitic nematodes and other plant pathogens. Certain rhizobacteria may induce systemic host resistance to nematodes and, in some instances, to foliage pathogens. The systems focusing on soil biology hold great promise for sustainable crop-nematode management, but only a few research programs are currently involved in this labor-intensive endeavor.

  8. System Transfer, Education, and Development in Mozambique

    Directory of Open Access Journals (Sweden)

    Jose Cossa

    2011-03-01

    Full Text Available In this study the author used conceptual historical method to assess the phenomenon of system transfer and the association between education and development in Mozambique. The assessment was administered through critical analysis of documents pertaining to the Salazar (1924-1966, Machel (1975-1986, and Chissano (1986-2005 administrations. The findings were that (a the colonial government created economic and educational systems for colonizing Mozambique, whereas the Machel and Chissano administrations adapted foreign systems of government and education (i.e., Socialism, Soviet, Democracy, Portuguese, etc., to their particular context without altering the inherent theoretical basis of the systems transferred; (b the Machel and Chissano administrations, implicitly or explicitly, perceived the relationship between education and development as circular causality rather than a unidirectional linear causality, while the Salazar administration perceived it as unidirectional linear causality; and (c while the Machel and Chissano administrations focused on primary education, literacy campaigns, and education of women and girls, they differed in the reasons for such focus.

  9. LC Filter for High Accuracy and Stability Digital MPS at PLS

    CERN Document Server

    Kim Sung Chul; Man Ha Ki; Yun Huang Jung

    2005-01-01

    High accuracy and stability digital power supply for magnet is developed at PLS. This power supply has three sections. The first section is digital controller including DSP&FPGA and precision ADC, the second consists of IGBT driver and four quad IGBT switch, and the third is LC output section. AC input voltage of power supply is 3-phase 21V, output current is 0 ~ 150 A dc. Switching frequency of IGBT is 25 kHz. The output current of power supply has very high accuracy of 100 mA step resolution at full range and the stability of ± 1.5 ppm for short term and ± 5 ppm for long term. This paper describes characteristics of filter and output current performance improvement after LC output filter at four quad digital power supplies.

  10. Development of decommissioning engineering support system for fugen. Development of support system during actual dismantlement works

    International Nuclear Information System (INIS)

    The Advanced Thermal Reactor, Fugen Nuclear Power Station was permanently shut down in March 2003, and is now preparing for decommissioning. We have been developing Decommissioning Engineering Support System (DEXUS) aimed at planning optimal dismantlement process and carrying out dismantlement work safely and precisely. DEXUS consists of 'decommissioning planning support system' and 'dismantling support system'. The dismantling support system is developed aiming at using during actual dismantling work. It consists of three subsystems such as 'Worksite Visualization System', 'Dismantling Data Collection System' and 'Generated Waste Management System'. 'Worksite Visualization System' is a support system designed to provide the necessary information to workers during actual dismantlement works. And this system adopts AR (Augmented Reality) technology, overlapping calculation information into real world. 'Dismantling Data Collection System' is to collect necessary data for improving accuracy of decommissioning planning by evaluating work content and worker equipage, work time for dismantlement works. 'Generated Waste Management system' is a system recording necessary information by attaching the barcode to dismantled wastes or the containers. We can get the information of generated waste by recording generation place, generated time, treatment method and the contents. These subsystems enable to carry out reasonable and safe decommissioning of Fugen. In addition, we expect that those systems will be used for decommissioning of other nuclear facilities in the future. (authors)

  11. Development of an intellectual maintenance management system. Development of trouble detection and troubleshooting evaluation system

    International Nuclear Information System (INIS)

    Many research activities are conducted to enhance cost performance and safety of nuclear power plants operation and maintenance. Concept of autonomous operating system to equal the role of operators and of maintenance personnel with artificial intelligence and autonomous robots has been developed. An intellectual maintenance management system has been developed to be equipped with decision making functions of maintenance personnel. The intellectual maintenance management system is in charge of maintenance function of an autonomous plant, which consists of plant-wide monitoring, evaluation of component integrity, and scheduling of maintenance activities. In other words, this system should be equipped with preventive maintenance and corrective maintenance functions those are currently loaded on personnel. In this report, we discussed condition monitoring maintenance in the preventive maintenance. We also reported a sensor validation system development for machinery condition monitoring and diagnosis. We adopted distributed and cooperative system construction technique, which is expected recently in applications to large-scale plants. This system has inter-agent communication function for signal transmission and reception among distributed physics models of machineries. The system has been constructed for water/steam system of the LMFBR power plant. The system has been validated to be capable of cooperative sensor validation by the distributed set of agents, with quantitative indication of sensor deviation based on a newly developed fuzzy algorithm with inter-agent cooperation. The derived reference parameter value from the inter-agent evaluations also stands for the alternative measurement to the malfunctioned sensor. (author)

  12. Effect of MPS concentration on ripening kinetics and structural properties of CdS quantum dots in self-assembled thin films

    Science.gov (United States)

    Koc, Kenan

    2015-12-01

    The colloidal CdS quantum dots (QDs) were synthesized with various molar ratios of 3-mercaptopropyltrimethoxysilane (MPS) molecules. The results show that the smaller size of CdS QDs was obtained at the higher molar concentration of MPS. Sol-gel spin coating method was used for deposition of the colloidal nanoparticles on a glass substrate. One pot production method was used to obtain self-assembled thin films of CdS QDs in SiO2 network and the grow kinetics of QDs were investigated. The samples were heat treated at various temperatures to observe the growth of the QDs. The sizes of the QDs were obtained in the range of 2-5 nm depending on the capping agent concentration and heat-treatment temperature. The activation energies for the Ostwald ripening process were found as 38.7, 56.4, 93,1 and 98.6 kJ/mol for the samples containing molar ratio of MPS:Cd = 0.25, 0.50, 1.00 and 2.00 respectively.

  13. Renal Function and NODM in De Novo Renal Transplant Recipients Treated with Standard and Reduced Levels of Tacrolimus in Combination with EC-MPS

    Directory of Open Access Journals (Sweden)

    Laurence Chan

    2012-01-01

    Full Text Available Information is lacking concerning concomitant administration of enteric-coated mycophenolate sodium with tacrolimus (EC-MPS+Tac in renal transplant recipients (RTxR. In this 6-month, prospective, open-label, multicenter study, de novo RTxR were randomized (1 : 1 to low-dose (LD or standard-dose (SD Tac with basiliximab, EC-MPS 720 mg bid, and steroids. Primary objective was to compare renal function at 6-month posttransplantation. Secondary objectives were to compare the incidences of biopsy-proven acute rejection (BPAR, graft loss and death, and new-onset diabetes mellitus (NODM. 292 patients (LD n=151, SD n=141 were included. Mean Tac levels were at the low end of the target range in standard-exposure patients (SD, n=141 and exceeded target range in low-exposure patients (LD = 151 throughout the study. There was no significant difference in mean glomerular filtration rate (GFR between treatments (ITT-population: 63.6 versus 61.0 mL/min. Incidence of BPAR was similar (10.6% versus 9.9%. NODM was significantly less frequent in LD Tac (17% versus 31%; P=0.02; other adverse effects (AEs were comparable. EC-MPS+Tac (LD/SD was efficacious and well tolerated with well-preserved renal function. No renal function benefits were demonstrated, possibly related to poor adherence to reduced Tac exposure.

  14. Quantum phase transitions about parity breaking in matrix product systems

    Institute of Scientific and Technical Information of China (English)

    ZHU Jing-Min

    2011-01-01

    According to our scheme to construct quantum phase transitions (QPTs) in spin chain systems with matrix product ground states, we first successfully combine matrix product state (MPS) QPTs with spontaneous symmetry breaking. For a concrete model, we take into account a kind of MPS QPTs accompanied by spontaneous parity breaking, though for either side of the critical point the GS is typically unique, and show that the kind of MPS QPTs occur only in the thermodynamic limit and are accompanied by the appearance of singularities, diverging correlation length, vanishing energy gap and the entanglement entropy of a half-infinite chain not only staying finite but also whose first derivative discontinuous.

  15. Development of Vertical Cable Seismic System (2)

    Science.gov (United States)

    Asakawa, E.; Murakami, F.; Tsukahara, H.; Ishikawa, K.

    2012-12-01

    The vertical cable seismic is one of the reflection seismic methods. It uses hydrophone arrays vertically moored from the seafloor to record acoustic waves generated by surface, deep-towed or ocean bottom sources. Analyzing the reflections from the sub-seabed, we could look into the subsurface structure. This type of survey is generally called VCS (Vertical Cable Seismic). Because VCS is an efficient high-resolution 3D seismic survey method for a spatially-bounded area, we proposed the method for the hydrothermal deposit survey tool development program that the Ministry of Education, Culture, Sports, Science and Technology (MEXT) started in 2009. We are now developing a VCS system, including not only data acquisition hardware but data processing and analysis technique. Our first experiment of VCS surveys has been carried out in Lake Biwa, JAPAN in November 2009 for a feasibility study. Prestack depth migration is applied to the 3D VCS data to obtain a high quality 3D depth volume. Based on the results from the feasibility study, we have developed two autonomous recording VCS systems. After we carried out a trial experiment in the actual ocean at a water depth of about 400m and we carried out the second VCS survey at Iheya Knoll with a deep-towed source. In this survey, we could establish the procedures for the deployment/recovery of the system and could examine the locations and the fluctuations of the vertical cables at a water depth of around 1000m. The acquired VCS data clearly shows the reflections from the sub-seafloor. Through the experiment, we could confirm that our VCS system works well even in the severe circumstances around the locations of seafloor hydrothermal deposits. We have carried out two field surveys in 2011. One is a 3D survey with a boomer for a high-resolution surface source and the other one for an actual field survey in the Izena Cauldron an active hydrothermal area in the Okinawa Trough. Through these surveys, we have confirmed that the

  16. Cognitive development in patients with Mucopolysaccharidosis type III (Sanfilippo syndrome)

    OpenAIRE

    Colland Vivian; Grootenhuis Martha; Marchal Jan; Valstar Marlies J; Wijburg Frits A

    2011-01-01

    Abstract Background Mucopolysaccharidosis type III (MPS III, Sanfilippo syndrome) is a lysosomal storage disorder caused by a deficiency of one of the enzymes involved in the degradation of heparan sulfate. MPS III is characterized by progressive mental deterioration resulting in severe dementia. A number of potentially disease-modifying therapies are studied. As preservation of cognitive function is the ultimate goal of treatment, assessment of cognitive development will be essential in orde...

  17. System Analysis in Developing an Effective Government Internal Audit System

    OpenAIRE

    Maliki Heru Santosa; Mohamad Syamsul Maarif; Eriyatno Eriyatno; Trias Andati

    2016-01-01

    Units of Government Internal Audit (GIA) play a significant role in developing a system of good governance. They contribute to the improvement of public services delivery and the welfare of society. But some current governance issues in Indonesia, such as corruption, accountability and performance problems, raise questions concerning the effectiveness of Indonesia’s GIA units. The complexity of these issues requires cybernetic study to find holistic and effective solutions. The objective of t...

  18. Lunar Surface Systems Supportability Technology Development Roadmap

    Science.gov (United States)

    Oeftering, Richard C.; Struk, Peter M.; Green, Jennifer L.; Chau, Savio N.; Curell, Philip C.; Dempsey, Cathy A.; Patterson, Linda P.; Robbins, William; Steele, Michael A.; DAnnunzio, Anthony; Meseroll, Robert; Quiter, John; Shannon, Russell; Easton, John W.; Madaras, Eric I.; BrownTaminger, Karen M.; Tabera, John T.; Tellado, Joseph; Williams, Marth K.; Zeitlin, Nancy P.

    2011-01-01

    The Lunar Surface Systems Supportability Technology Development Roadmap is a guide for developing the technologies needed to enable the supportable, sustainable, and affordable exploration of the Moon and other destinations beyond Earth. Supportability is defined in terms of space maintenance, repair, and related logistics. This report considers the supportability lessons learned from NASA and the Department of Defense. Lunar Outpost supportability needs are summarized, and a supportability technology strategy is established to make the transition from high logistics dependence to logistics independence. This strategy will enable flight crews to act effectively to respond to problems and exploit opportunities in an environment of extreme resource scarcity and isolation. The supportability roadmap defines the general technology selection criteria. Technologies are organized into three categories: diagnostics, test, and verification; maintenance and repair; and scavenge and recycle. Furthermore, "embedded technologies" and "process technologies" are used to designate distinct technology types with different development cycles. The roadmap examines the current technology readiness level and lays out a four-phase incremental development schedule with selection decision gates. The supportability technology roadmap is intended to develop technologies with the widest possible capability and utility while minimizing the impact on crew time and training and remaining within the time and cost constraints of the program.

  19. EU developments of the ITER ECRH system

    International Nuclear Information System (INIS)

    The EU will be providing the largest contribution to the ITER electron cyclotron (EC) heating and current drive (H and CD) system (20 MW, CW at 170 GHz). The contribution includes one third of the H and CD gyrotrons, their associated power supplies and four upper port launcher antennas. In all areas of participation, the EU EC partnership (coordinated by the European Fusion Development Agreement) aims toward advancing the technology, while staying within a specified cost envelope. This is portrayed in the co-axial gyrotron development that offers the potential to double the output power per source (2.0 MW), increasing the delivered power for a fixed number of auxiliary systems. The EU partnerships also attempt to increase performance for the entire EC system, in particular the launching antennas. The proposed front steering launcher design offers greater control of MHD activity than the previous remote steering design and opens up the possibility of an enhanced performance UL. The EC physics requirements are repartitioned between the upper and equatorial launchers for a synergetic balance, which increases the EC physics capabilities while relaxing some of the engineering requirements

  20. Nematode model systems in evolution and development.

    Science.gov (United States)

    Sommer, Ralf J; Bumbarger, Daniel J

    2012-01-01

    The free-living nematode Caenorhabditis elegans is one of the most important model organisms in all areas of modern biology. Using the knowledge about C. elegans as a baseline, nematodes are now intensively studied in evolution and development. Evolutionary developmental biology or for short, 'evo-devo' has been developed as a new research discipline during the last two decades to investigate how changes in developmental processes and mechanisms result in the modification of morphological structures and phenotypic novelty. In this article, we review the concepts that make nematode evo-devo a successful approach to evolutionary biology. We introduce selected model systems for nematode evo-devo and provide a detailed discussion of four selected case studies. The most striking finding of nematode evo-devo is the magnitude of developmental variation in the context of a conserved body plan. Detailed investigation of early embryogenesis, gonad formation, vulva development, and sex determination revealed that molecular mechanisms evolve rapidly, often in the context of a conserved body plan. These studies highlight the importance of developmental systems drift and neutrality in evolution. PMID:23801489

  1. Advanced systems: Status and development prospects

    International Nuclear Information System (INIS)

    World reserves of coal, uranium, thorium and thermonuclear fuel (deuterium and lithium) are sufficient to provide mankind with energy for many centuries. The rate of increase in demand is unlikely to be a limiting factor, and it would seem that any ''limits to growth'' will be dictated by other, in particular ecological, factors. In the last two decades, world power production has developed a structure in which a predominant place is occupied by oil and gas; this will have to change as a result of the marked depletion of oil resources and the enhanced role played in the fuel balance by power from coal and nuclear fission, on which, it would seem, the long-term growth of world energy production will be based. The contribution of nuclear fission power towards meeting world energy needs will depend on a number of factors, the most important of which from a long-term point of view is the time and rate of introduction of advanced nuclear power systems and fuel cycles with high nuclear fuel surpluses (breeding ratios). The results of almost 30 years of development of nuclear power with thermal-neutron reactors may serve as a basis for the analysis, evaluation and forecasting of the development of advanced systems. (author)

  2. Development of decommissioning system engineering technology

    International Nuclear Information System (INIS)

    In the decommissioning planning stage, it is important to select the optimized decommissioning process considering the cost and safety. Especially the selection of the optimized decommissioning process is necessary because it affects to improve worker's safety and decommissioning work efficiency. The decommissioning process evaluation technology can provide the optimized decommissioning process as constructing various decommissioning scenarios and it can help to prevent the potential accidents as delivering the exact work procedures to workers and to help workers to perform decommissioning work skillfully. It's necessary to measure the radioactive contamination in the highly contaminated facilities such as hot-cells or glove-boxes to be decommissioned for decommissioning planning. These facilities are very high radiation level, so it is difficult to approach. In this case the detector system is preferable to separate the sensor and electronics, which have to locate in the facility outside to avoid the electric noise and worker's radiation exposure. In this project, we developed the remote detection system for radiation measurement and signal transmission in the high radiation area. In order to minimize worker's exposure when decommissioning highly activated nuclear facilities, it is necessary to develop the remote handling tool to perform the dismantling work remotely. Especially, since cutting, measuring, and decontamination works should be performed remotely in the highly activated area, the remote handling tool for conducting these works should be developed. Therefore, the multi-purpose dismantling machine that can measuring dose, facility cutting, and remote handling for maintenance and decommissioning of highly activated facility should be needed

  3. Development of the Open Items Tracking System

    Energy Technology Data Exchange (ETDEWEB)

    Riggi, V.

    1994-06-01

    The West Valley Demonstration Project, located on the site of the only commercial nuclear fuel reprocessing facility to have operated in USA, has the directed objectives of solidifying the high-level radioactive waste into a durable, solid form for shipment; decontaminating and decommissioning the tanks and facilities; and disposing of the resulting low-level and transuranic wastes. Since an escalating trend of open work items was noticed in the Fall of 1988, and there was no control mechanism for tracking and closing the open items, a Work Control System was developed for this purpose. It is self-contained system on a mainframe ARTEMIS 9000, which tracks, monitors, and closes out external commitments in a timely manner. Audits, surveillances, site appraisals, preventive maintenance, instrument calibration recall, and scheduling are covered.

  4. Development of energy and transport systems

    International Nuclear Information System (INIS)

    Economic development and the advancement of technology is presented as a process of substituting old forms of satisfying human needs by new ones or, more precisely, as a sequence of such substitutions. The examples, reconstructed from historical records, describe the quantitative, technological changes in energy and transport systems. The analysis of historical replacement of old by new technologies has shown that most of these processes can be described by simple rules that are captured in the logistic substitution model, and that technological substitution, expressed in terms of market shares, follows characteristic S-shaped curves. To illustrate the properties of the approach examples are given of how new energy forms replaced their predecessors. To further explore the method similar substitution processes in transport systems are described. 21 refs, 23 figs, 1 tab

  5. DEVELOPMENT AND MARKET OF ERP SYSTEMS

    Directory of Open Access Journals (Sweden)

    DIANA-ELENA CODREANU

    2012-11-01

    Full Text Available The business environment’s changes occurring more and more quickly and company activities’ becoming more and more complex require permanent, fast adjustments which often test human factors’ abilities for efforts and analyses. The creation and development of ERP-type systems have been and are still believed to be the solutions of such challenges ensuring certain support to process large amounts of data and information needed in companies’ decision-making processes. An ERP system helps the integration of a company’s set of information into a single platform due to the way in which it succeeds in combining business management techniques and practices with the new information technology, providing the transparency of data and the access to the necessary information.

  6. Development of the Open Items Tracking System

    International Nuclear Information System (INIS)

    The West Valley Demonstration Project, located on the site of the only commercial nuclear fuel reprocessing facility to have operated in USA, has the directed objectives of solidifying the high-level radioactive waste into a durable, solid form for shipment; decontaminating and decommissioning the tanks and facilities; and disposing of the resulting low-level and transuranic wastes. Since an escalating trend of open work items was noticed in the Fall of 1988, and there was no control mechanism for tracking and closing the open items, a Work Control System was developed for this purpose. It is self-contained system on a mainframe ARTEMIS 9000, which tracks, monitors, and closes out external commitments in a timely manner. Audits, surveillances, site appraisals, preventive maintenance, instrument calibration recall, and scheduling are covered

  7. Development of the power system for accelerator

    International Nuclear Information System (INIS)

    The 100-MeV proton linac needs 4 modulators whose specification is as follows, -115kV, 55A, and 9%. The development of the modulators were successfully finished and installed at Gyeongju site of KAERI. One of them was used and successfully tested in the 20-MeV linac operation at Daejeon site. The klystron is used to supply the high power RF into the accelerating structure. There are 2 klystrons for 20-MeV part of the linac and 7 klystrons from 20-MeV to 100-MeV region. The maximum voltage is ?105kV, the peak power is 1.6 MW, and the duty is 9%. All of the 7 klystrons have been fabricated, tested and installed. The high power RF system includes circulators, dummy lodes, RF windows, and wave-guides. The development of the high power RF components was finished and they were installed at the Gyeongju site. The 11 sets of RCCS (resonant control cooling system) will be used to control the cooling water temperature inside the accelerating structure. The temperature range of the cooling water covers between 21 .deg. C and 33 .deg. C with the 0.1 .deg. C control. All RCCSs were installed in the klystron gallery. Purposes of the 20-MeV linac operation at Daejeon site of KAERI (2007∼2011) are to supply proton beams to user, to porve the accelerator performance, to test the developed components including LLRF, diagnostics, and control system, and to measure the proton beam properties. During the period, the total number of samples reaches to 1,603 and the average machine availability becomes 96.2%. The 20-MeV linac was disassembled, moved and installed at Gyeongju site after finishing the test operation

  8. Development of the High Energy Linac Systems

    International Nuclear Information System (INIS)

    The main purpose of this project is studying the extension plan of the proton engineering frontier project (PEFP) 100-MeV Linac. It includes three categories. One is studying operation plan of the PEFP linac and its extended accelerators, and developing a distribution system of 100-MeV proton beams with a laser striping. Other is designing superconducting RF (SRF) modules and fabricating and testing a copper cavity model. The other is designing a rapid cycling synchrotron (RCS). The operation scheme of the PEFP linac is related to the optimization in the operation of the 100-MeV linac, 200-MeV SRF, and RCS. We studied several operational method to increase the validity of the accelerators. The beam distribution system has two roles. One is supplying proton beams of 100 MeV to the user group. The laser stripping of the negative hydrogen atoms is used in this case. The other beams are directed to the next high energy accelerators. This study contributes to increase the availability of the proton beams. The SRF is one of candidates to extend the PEFP linac system. Since the accelerating gradient of the SRF is much higher than the normal conducting accelerator, a lot of institutes over the world are developing the SRF structure. Main purposes are designing an SRF module, fabricating and testing an copper model which has similar material properties as Nb of the usual SRF cavity material. The RCS is a synchrotron whose injector is the PEFP 100-MeV linac. Main purposes are determining the lattice structure, studying the fast and slow extraction system, simulating beam behavior in the designed synchrotron. The RCS will be used as the spallation neutron source and tools in the basic and applied science including medical application

  9. Simulation as a decisison support tool in maintenance float systems

    OpenAIRE

    Pereira, Guilherme; Peito, Francisco; Leitão, Armando; Dias, Luís M. S.

    2011-01-01

    This paper is concerned with the use of simulation as a decision support tool in maintenance systems, specifically in MPS (Maintenance Float Systems). For this purpose and due to its high complexity, in this paper the authors explore and present a possible way to construct a MPS model using Arena® simulation language, where some of the most common performance measures are identified, calculated and analysed.

  10. Recent developments in modeling groundwater systems

    Energy Technology Data Exchange (ETDEWEB)

    Narasimhan, T.N.; Witherspoon, P.A.

    1977-05-20

    This paper reviews the developments in the mathematical modeling of groundwater systems over the past decde. The first part of the paper is devoted to a description of the physics of the different types of problems that are of interest in hydrogeology and a statement of the related initial-boundary-value problems. The various numerical techniques that have been employed to solve the governing equations are discussed in the second part. In the third section a few typical case histories are presented to illustrate the trend of progress that has occurred in the application of mathematical modeling to actual field problems.

  11. Systems strategies for developing industrial microbial strains

    DEFF Research Database (Denmark)

    Lee, Sang Yup; Kim, Hyun Uk

    2015-01-01

    Industrial strain development requires system-wide engineering and optimization of cellular metabolism while considering industrially relevant fermentation and recovery processes. It can be conceptualized as several strategies, which may be implemented in an iterative fashion and in different ord...... achievements in recent years include microbial production of amino acids (L-valine, L-threonine, L-lysine and L-arginine), bulk chemicals (1,4-butanediol, 1,4-diaminobutane, 1,5-diaminopentane, 1,3-propanediol, butanol, isobutanol and succinic acid) and drugs (artemisinin)....

  12. Development techniques of computerized maintenance Management system

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Yon Woo; Kim, S.D.; Soong, W.S.; Kim, G.H.; Oh, W.H.; Kim, Y.G

    2000-05-01

    Normal operation of the facility is one of the key factors in the accomplishments of research goals. As confirmed by a case study of the influence of the facility operation condition on the research results, emphasis should be put on the facility preserve management. Facilities should be maintained in solid operational condition and their malfunctions should be repaired as soon as possible. The purpose of this project is to make propositions on the development of the facility preserve management system which is to maximize the efficiency of the budget execution, manpower organization and maintenance planning, and is to minimize the duration of the operational pause due to malfunctions with the least disbursement.

  13. Recent development of plasma optical systems (invited)

    Energy Technology Data Exchange (ETDEWEB)

    Goncharov, A. A., E-mail: gonchar@iop.kiev.ua [Institute of Physics, National Academy of Science, Kiev 03028 (Ukraine)

    2016-02-15

    The article devotes a brief description of the recent development and current status of an ongoing research of plasma optical systems based on the fundamental plasma optical idea magnetic electron isolation, equipotentialization magnetic field lines, and the axi-symmetric cylindrical electrostatic plasma lens (PL) configuration. The experimental, theoretical, and simulation investigations have been carried out over recent years collaboratively between IP NASU (Kiev), LBNL (Berkeley, USA), and HCEI RAS (Tomsk). The crossed electric and magnetic fields inherent the PL configuration that provides the attractive method for establishing a stable plasma discharge at low pressure. Using PL configuration, several high reliability plasma devices were developed. These devices are attractive for many high-tech applications.

  14. Recent development of plasma optical systems (invited)

    Science.gov (United States)

    Goncharov, A. A.

    2016-02-01

    The article devotes a brief description of the recent development and current status of an ongoing research of plasma optical systems based on the fundamental plasma optical idea magnetic electron isolation, equipotentialization magnetic field lines, and the axi-symmetric cylindrical electrostatic plasma lens (PL) configuration. The experimental, theoretical, and simulation investigations have been carried out over recent years collaboratively between IP NASU (Kiev), LBNL (Berkeley, USA), and HCEI RAS (Tomsk). The crossed electric and magnetic fields inherent the PL configuration that provides the attractive method for establishing a stable plasma discharge at low pressure. Using PL configuration, several high reliability plasma devices were developed. These devices are attractive for many high-tech applications.

  15. Development of a multispectral camera system

    Science.gov (United States)

    Sugiura, Hiroaki; Kuno, Tetsuya; Watanabe, Norihiro; Matoba, Narihiro; Hayashi, Junichiro; Miyake, Yoichi

    2000-05-01

    A highly accurate multispectral camera and the application software have been developed as a practical system to capture digital images of the artworks stored in galleries and museums. Instead of recording color data in the conventional three RGB primary colors, the newly developed camera and the software carry out a pixel-wise estimation of spectral reflectance, the color data specific to the object, to enable the practical multispectral imaging. In order to realize the accurate multispectral imaging, the dynamic range of the camera is set to 14 bits or over and the output bits to 14 bits so as to allow capturing even when the difference in light quantity between the each channel is large. Further, a small-size rotary color filter was simultaneously developed to keep the camera to a practical size. We have developed software capable of selecting the optimum combination of color filters available in the market. Using this software, n types of color filter can be selected from m types of color filter giving a minimum Euclidean distance or minimum color difference in CIELAB color space between actual and estimated spectral reflectance as to 147 types of oil paint samples.

  16. Development of small, modular biomass power systems

    Energy Technology Data Exchange (ETDEWEB)

    Turnbull, J.H. [Peninsula Energy Partners, Los Altos, CA (United States); Hulkkonen, S. [IVO/EPRI, Palo Alto, CA (United States); Dracker, R. [Bechtel Corp., San Francisco, CA (United States)

    1996-12-31

    This paper describes a collaborative effort between the Electric Power Research Institute, Bechtel Corporation and Imatran Voima Oy. The goal is commercialization of a biomass-fueled, modular (50 to 250 kW) heat and power technology for distributed applications. The technology to be selected will not present any major technical challenges, but first and foremost must be simple and reliable. Additional criteria include: acceptable capital cost, fuel flexibility, and the capability for meeting local environmental standards. As the capital cost of small units will be influenced by economies of fabrication, the economic viability of these systems depends upon the size of the domestic and international markets. Thus, evaluation of available conversion technologies was undertaken concurrently with a broad-based market assessment. The technology scan included all the commercial and pre-commercial biomass systems that could be located. Information was sorted into five categories: (1) gasifiers with either diesel or spark-ignited engines; (2) indirectly fired gas turbines; (3) directly fired gas turbines; (4) pyrolysis processes with diesel engines; or (5) conventional steam-cycles. The evaluation of the technologies was based on the above criteria, along with the recognition that the levelized cost of power from the system must be competitive with available diesel generation. The market for these systems within the contiguous 48 states is expected to be limited to situations involving forest ecosystem improvements and the reduction of forest fire hazards, and/or clean-up and remediation following natural disasters. Another North American market is remote villages in Canada and Alaska. By far the largest market is in developing nations where two billion people are without electricity for lighting, water pumping or refrigeration. Serving this latter market presents a major challenge, as each system will require establishment of a whole new local infrastructure.

  17. Genotoxic sensitivity of the developing hematopoietic system.

    Science.gov (United States)

    Udroiu, Ion; Sgura, Antonella

    2016-01-01

    Genotoxic sensitivity seems to vary during ontogenetic development. Animal studies have shown that the spontaneous mutation rate is higher during pregnancy and infancy than in adulthood. Human and animal studies have found higher levels of DNA damage and mutations induced by mutagens in fetuses/newborns than in adults. This greater susceptibility could be due to reduced DNA repair capacity. In fact, several studies indicated that some DNA repair pathways seem to be deficient during ontogenesis. This has been demonstrated also in murine hematopoietic stem cells. Genotoxicity in the hematopoietic system has been widely studied for several reasons: it is easy to assess, deals with populations cycling also in the adults and may be relevant for leukemogenesis. Reviewing the literature concerning the application of the micronucleus test (a validated assay to assess genotoxicity) in fetus/newborns and adults, we found that the former show almost always higher values than the latter, both in animals treated with genotoxic substances and in those untreated. Therefore, we draw the conclusion that the genotoxic sensitivity of the hematopoietic system is more pronounced during fetal life and decreases during ontogenic development. PMID:27036061

  18. Development of flat panel digital radiography system

    International Nuclear Information System (INIS)

    We developed the Digital Radiography System CXDI-11 which digitizes the X-ray image in high quality by using a self-developed flat panel detector. The CXDI-11 has a large image area of 43 cm x 43 cm (17'' x 17''), and it can display the image on the pre-view monitor after only 3 seconds of exposure. In this report, we present the principle and the physical characteristics of the CXDI-11. The X-ray detector installed in the CXDI-11 is a combination of a rare-earth scintillator and an amorphous silicon flat panel detector (LANMIT). The X-ray is converted to the visible fluorescent light at the scintillator and the light is detected by the LANMIT. The image-processed data is transferred to the DICOM3.0 conformed devices such as the diagnosis work station, the archiver and the laser imager through the network. We also show some measurement results of the dynamic range, the pre-sampling Modulation Transfer Function and the tube voltage dependent sensitivity. The CXDI-11 is superior in real time operation and image quality, thus it is the digital radiography system of the next generation. (author)

  19. MPs reminded of responsibilities

    Index Scriptorium Estoniae

    2011-01-01

    Riigikogult valitsuse moodustamiseks volituse saanud peaminister Andrus Ansip tutvustas ministrikandidaate president Toomas Hendrik Ilvesele. Presidendi kõnest Riigikogu XII koosseisu avaistungil 4. apr. 2011

  20. System Analysis in Developing an Effective Government Internal Audit System

    Directory of Open Access Journals (Sweden)

    Maliki Heru Santosa

    2016-01-01

    Full Text Available Units of Government Internal Audit (GIA play a significant role in developing a system of good governance. They contribute to the improvement of public services delivery and the welfare of society. But some current governance issues in Indonesia, such as corruption, accountability and performance problems, raise questions concerning the effectiveness of Indonesia’s GIA units. The complexity of these issues requires cybernetic study to find holistic and effective solutions. The objective of this study is to examine the effectiveness of government internal audit systems in order to enhance the professionalism of government internal auditors and the maturity of the management processes that they audit.  This research was based on qualitative approaches with systems methodology. The instruments used during the research were regulatory analysis, survey, and in-depth interviews. The survey involved 205 Chief Audit Executives (CAE of Government Internal Supervisory Apparatus (GISA in national government and regional governments, and was conducted on-line or on paper. The survey was complemented by in-depth interview with 24 (twenty four senior stakeholders representing practitioners (the CAE of GISA units, internal users (governors, mayors, heads of regional planning agencies, external users (Indonesia’s Supreme Audit Board, SAB, regulators, and associations of professional internal auditors, both private sector (IIA and public sector (AAIPI. The research found that the effort of enhancing the role of the GIA units should be seen holistically. The improvement of the role of GIA units related to the stakeholders, including management line of the organization, the SAB, professional associations, regulators, and law enforcement officials as well as other factors. The arrangement of the internal audit system could allow the government auditors to improve their professionalism and help line management to mature their management processes. The emerging

  1. Power Systems Development Facility. Environmental Assessment

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    The objective of the PSDF would be to provide a modular facility which would support the development of advanced, pilot-scale, coal-based power systems and hot gas clean-up components. These pilot-scale components would be designed to be large enough so that the results can be related and projected to commercial systems. The facility would use a modular approach to enhance the flexibility and capability for testing; consequently, overall capital and operating costs when compared with stand-alone facilities would be reduced by sharing resources common to different modules. The facility would identify and resolve technical barrier, as well as-provide a structure for long-term testing and performance assessment. It is also intended that the facility would evaluate the operational and performance characteristics of the advanced power systems with both bituminous and subbituminous coals. Five technology-based experimental modules are proposed for the PSDF: (1) an advanced gasifier module, (2) a fuel cell test module, (3) a PFBC module, (4) a combustion gas turbine module, and (5) a module comprised of five hot gas cleanup particulate control devices. The final module, the PCD, would capture coal-derived ash and particles from both the PFBC and advanced gasifier gas streams to provide for overall particulate emission control, as well as to protect the combustion turbine and the fuel cell.

  2. Development of the environmental neutron detection system

    CERN Document Server

    Kume, K

    2003-01-01

    Environmental neutron detection system is proposed. The main goal of this system was set to detect fast and thermal neutrons with the identical detector setup without degraders. A detector setup for the system with a sup 1 sup 0 B doped liquid scintillator, which had been optimized for thermal neutron counting in last year, was developed first. For optimization of for fast neutron counting, density of sup 1 sup 0 B and the size of the detector were fixed by measurement of fast neutrons, with help of the Monte Carlo calculation. In the meantime, possibility of the use of inorganic scintillators in neutron counting were verified, to solve the problem occurring at the long term use of the organic liquid scintillators. The detectors checked were LSO, BaF sub 2 , BGO and GSO. LSO and BaF sub 2 have much more difficulties in neutron counting such as background counting rates and BGO has some unclear signals at neutron measurements. GSO was shown to be the most probable candidate among them at the measurement of neu...

  3. Development of the environmental data management system

    International Nuclear Information System (INIS)

    The recent society requires business activities with environmental consideration to every enterprise. Also, Japanese laws require those activities. For example, 'Law Concerning the Promotion of Business Activities with Environmental Consideration by Specified Corporations, etc, by Facilitating Access to Environmental Information, and Other Measures' (Environmental Consideration Law) mandates publication of a report relating to the activities of environmental consideration to each enterprise above designated size. 'Act on the Rational Use of Energy' mandates the report of the results of energy consumption and the long-term plan of the rational use of energy. Moreover, 'Act on Promotion of Global Warming Countermeasures' mandates the report of the greenhouse gas emissions. In addition to those, 'Water Pollution Control Law', 'Waste Management and Public Cleaning Law' and other environmental laws as well as environmental ordinances require business activities with environmental consideration to all companies. So, it is very important for Japan Atomic Energy Agency (JAEA) to report business activities with environmental consideration in order to build up trustful relations with the nation and communities. The Environmental Data Management System has been developed as the data base of business activities with environmental consideration in JAEA and as the means to promote the activities at every site and office of JAEA. This report summarizes the structure of the Environmental Data Management System, kinds of environmental performance data treated by the system, and gathering methods of the data. (author)

  4. Advanced Electric Traction System Technology Development

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Iver

    2011-01-14

    As a subcontractor to General Motors (GM), Ames Laboratory provided the technical expertise and supplied experimental materials needed to assess the technology of high energy bonded permanent magnets that are injection or compression molded for use in the Advanced Electric Traction System motor. This support was a sustained (Phase 1: 6/07 to 3/08) engineering effort that builds on the research achievements of the primary FreedomCAR project at Ames Laboratory on development of high temperature magnet alloy particulate in both flake and spherical powder forms. Ames Lab also provide guidance and direction in selection of magnet materials and supported the fabrication of experimental magnet materials for development of injection molding and magnetization processes by Arnold Magnetics, another project partner. The work with Arnold Magnetics involved a close collaboration on particulate material design and processing to achieve enhanced particulate properties and magnetic performance in the resulting bonded magnets. The overall project direction was provided by GM Program Management and two design reviews were held at GM-ATC in Torrance, CA. Ames Lab utilized current expertise in magnet powder alloy design and processing, along with on-going research advances being achieved under the existing FreedomCAR Program project to help guide and direct work during Phase 1 for the Advanced Electric Traction System Technology Development Program. The technical tasks included review of previous GM and Arnold Magnets work and identification of improvements to the benchmark magnet material, Magnequench MQP-14-12. Other benchmark characteristics of the desired magnet material include 64% volumetric loading with PPS polymer and a recommended maximum use temperature of 200C. A collaborative relationship was maintained with Arnold Magnets on the specification and processing of the bonded magnet material required by GM-ATC.

  5. New developments in prosthetic arm systems

    Directory of Open Access Journals (Sweden)

    Vujaklija I

    2016-07-01

    Full Text Available Ivan Vujaklija,1 Dario Farina,1 Oskar C Aszmann2 1Institute of Neurorehabilitation Systems, Bernstein Focus Neurotechnology Göttingen, University Medical Center Göttingen, Georg-August University, Göttingen, Germany; 2Christian Doppler Laboratory for Restoration of Extremity Function, Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria Abstract: Absence of an upper limb leads to severe impairments in everyday life, which can further influence the social and mental state. For these reasons, early developments in cosmetic and body-driven prostheses date some centuries ago, and they have been evolving ever since. Following the end of the Second World War, rapid developments in technology resulted in powered myoelectric hand prosthetics. In the years to come, these devices were common on the market, though they still suffered high user abandonment rates. The reasons for rejection were trifold – insufficient functionality of the hardware, fragile design, and cumbersome control. In the last decade, both academia and industry have reached major improvements concerning technical features of upper limb prosthetics and methods for their interfacing and control. Advanced robotic hands are offered by several vendors and research groups, with a variety of active and passive wrist options that can be articulated across several degrees of freedom. Nowadays, elbow joint designs include active solutions with different weight and power options. Control features are getting progressively more sophisticated, offering options for multiple sensor integration and multi-joint articulation. Latest developments in socket designs are capable of facilitating implantable and multiple surface electromyography sensors in both traditional and osseointegration-based systems. Novel surgical techniques in combination with modern, sophisticated hardware are enabling restoration of dexterous upper limb

  6. Advanced Turbine Systems Program industrial system concept development

    Energy Technology Data Exchange (ETDEWEB)

    Gates, S.

    1995-12-31

    Solar approached Phase II of ATS program with the goal of 50% thermal efficiency. An intercolled and recuperated gas turbine was identified as the ultimate system to meet this goal in a commercial gas turbine environment. With commercial input from detailed market studies and DOE`s ATS program, Solar redefined the company`s proposed ATS to fit both market and sponsor (DOE) requirements. Resulting optimized recuperated gas turbine will be developed in two sizes, 5 and 15 MWe. It will show a thermal efficiency of about 43%, a 23% improvement over current industrial gas turbines. Other ATS goals--emissions, RAMD (reliability, availability, maintainability, durability), cost of power--will be met or exceeded. During FY95, advanced development of key materials, combustion and component technologies proceeded to the point of acceptance for inclusion in ATS Phase III.

  7. Development of novel emission tomography system

    Science.gov (United States)

    Fu, Geng

    In recent years, small animals, such as mice and rats, have been widely used as subjects of study in biomedical research while molecular biology and imaging techniques open new opportunities to investigate disease model. With the help of medical imaging techniques, researchers can investigate underlying mechanisms inside the small animal, which are useful for both early diagnosis and treatment monitoring. Based on tracer principle single photon emission computed tomography (SPECT) has increased popularity in small animal imaging due to its higher spatial resolution and variety of single-photon emitting radionuclides. Since the image quality strongly depends on the detector properties, both scintillation and semiconductor detectors are under active investigation for high resolution X-ray and gamma ray photon detection. The desired detector properties include high intrinsic spatial resolution, high energy resolution, and high detection efficiency. In this thesis study, we have made extensive efforts to develop novel emission tomography system, and evaluate the use of both semiconductor and ultra-high resolution scintillation detectors for small animal imaging. This thesis work includes the following three areas. Firstly, we have developed a novel energy-resolved photon counting (ERPC) detector. With the benefits of high energy resolution, high spatial resolution, flexible detection area, and a wide dynamic range of 27--200keV, ERPC detector is well-suited for small animal SPECT applications. For prototype ERPC detector excellent imaging (˜350microm) and spectroscopic performance (4keV Co-57 122keV) has been demonstrated in preliminary study. Secondly, to further improve spatial resolution to hundred-micron level, an ultra-high resolution Intensified EMCCD (I-EMCCD) detector has been designed and evaluated. This detector consists of the newly developed electron multiplying CCD (EMCCD) sensor, columnar CsI(Tl) scintillator, and an electrostatic de-magnifier (DM) tube

  8. Development and Control of a Non Linear Magnetic Levitation System

    Directory of Open Access Journals (Sweden)

    A Sanjeevi Gandhi

    2013-06-01

    Full Text Available Nowadays, studies to develop and control non linear systems is of great significance. Magnetic Levitation System has gained considerable interests due to its great practical importance in different engineering fields In this paper an electromagnetic levitation system was developed and mathematical model for the system was derived. The developed system was controlled manually.

  9. Development and Control of a Non Linear Magnetic Levitation System

    OpenAIRE

    A Sanjeevi Gandhi; Reshma Angelene Jose

    2013-01-01

    Nowadays, studies to develop and control non linear systems is of great significance. Magnetic Levitation System has gained considerable interests due to its great practical importance in different engineering fields In this paper an electromagnetic levitation system was developed and mathematical model for the system was derived. The developed system was controlled manually.

  10. Geographic Information Systems and Web Page Development

    Science.gov (United States)

    Reynolds, Justin

    2004-01-01

    The Facilities Engineering and Architectural Branch is responsible for the design and maintenance of buildings, laboratories, and civil structures. In order to improve efficiency and quality, the FEAB has dedicated itself to establishing a data infrastructure based on Geographic Information Systems, GIs. The value of GIS was explained in an article dating back to 1980 entitled "Need for a Multipurpose Cadastre which stated, "There is a critical need for a better land-information system in the United States to improve land-conveyance procedures, furnish a basis for equitable taxation, and provide much-needed information for resource management and environmental planning." Scientists and engineers both point to GIS as the solution. What is GIS? According to most text books, Geographic Information Systems is a class of software that stores, manages, and analyzes mapable features on, above, or below the surface of the earth. GIS software is basically database management software to the management of spatial data and information. Simply put, Geographic Information Systems manage, analyze, chart, graph, and map spatial information. At the outset, I was given goals and expectations from my branch and from my mentor with regards to the further implementation of GIs. Those goals are as follows: (1) Continue the development of GIS for the underground structures. (2) Extract and export annotated data from AutoCAD drawing files and construct a database (to serve as a prototype for future work). (3) Examine existing underground record drawings to determine existing and non-existing underground tanks. Once this data was collected and analyzed, I set out on the task of creating a user-friendly database that could be assessed by all members of the branch. It was important that the database be built using programs that most employees already possess, ruling out most AutoCAD-based viewers. Therefore, I set out to create an Access database that translated onto the web using Internet

  11. Development of CRT's corner cutting repair systems

    Institute of Scientific and Technical Information of China (English)

    QU Hui-ming; CHEN Qian

    2005-01-01

    CRT Corner cutting tube is considered as a definitive reject and will be sent to reclaim at all times. It caused lots of material loss. In this paper, a novel technology used to save CRTs corner cutting tube is presented firstly. A set of repair system has been successfully developed to repair CRTs corner cutting tube. Then, the process technology for corner cutting repair has been excogitated by empirical studies.Finally,the correlative performances of repaired tube are evaluated. The experimental results show that the quality of repaired tube has no difference with that of normal product. The repair yield has reached above 97 percent. This new technology has contributed to improving the production yield,reducing the material consumption and decreasing the cost of color CRT production.

  12. Development of CRD stub tube welding system

    International Nuclear Information System (INIS)

    The reactor pressure vessel (RPV) of nuclear power plants include control rod drive (CRD) stub tubes installed on the inner surface of the bottom head by welding. Weld seams are located at the root of each stub tube, to which accessibility is limited. The weld travel requires an elliptical movement with inclination along the inner bottom head surface, and furthermore the location on the bottom head of each stub tube has different angle of inclination. CRD stub tubes were installed by skilled welders using MIG welding in previous RPV construction. Recently, a CRD stub tube TIG welding system was developed for RPV construction in the near future, which can be applied to such 3 dimensional welding orbit. (author)

  13. Reliable Software Development for Machine Protection Systems

    CERN Document Server

    Anderson, D; Dragu, M; Fuchsberger, K; Garnier, JC; Gorzawski, AA; Koza, M; Krol, K; Misiowiec, K; Stamos, K; Zerlauth, M

    2014-01-01

    The Controls software for the Large Hadron Collider (LHC) at CERN, with more than 150 millions lines of code, resides amongst the largest known code bases in the world1. Industry has been applying Agile software engineering techniques for more than two decades now, and the advantages of these techniques can no longer be ignored to manage the code base for large projects within the accelerator community. Furthermore, CERN is a particular environment due to the high personnel turnover and manpower limitations, where applying Agile processes can improve both, the codebase management as well as its quality. This paper presents the successful application of the Agile software development process Scrum for machine protection systems at CERN, the quality standards and infrastructure introduced together with the Agile process as well as the challenges encountered to adapt it to the CERN environment.

  14. Development of portable driving simulator system

    Directory of Open Access Journals (Sweden)

    Y. Itoh

    2008-08-01

    Full Text Available Purpose: In accordance with aging of populations in many developed countries, number of drivers who suffer from mild cognitive impairment (MCI drivers is increasing. Since it has been reported that driving skill of the MCI drivers are deteriorated, it is important to train themselves in driving situation to preserve their driving skills. The present study was conducted to develop the simple driving simulator system, and to examine the effect of training in this system.Design/methodology/approach: Nineteen university students (8 males and 11 females participated in this study. After the habituation period (approximately 5min, three trials (approximately 12 min were conducted. Experimental situation imitated the real highway course. During trials, dangerous situation that would be resulted in car accident is randomly appeared and participants were required to avoid the car accidents. To avoid the possible car accidents are considered as correct response.Findings: Mean percent of correct responses for male and female were 75.2% and 56.6% in 1st trial and 95.7% and 72.6% in 3rd trial, respectively. Two-way analysis of variance revealed that the main effect of sex(F (1, 14 = 7.84, p < .05 and trials (F (2, 34 = 10.19, p < .001. These results indicate that numbers of car accidents are dramatically decreased and the driving skills of male are superior to that of female.Practical implications: Although the present study revealed the differences in driving skills between the sexes, their driving history was not considered. Driving history of each participant should be examined in future study.Originality/value: Since the improvement of driving skills is revealed, our experimental design is expected as the tool for the preservation of driving skills in the MCI drivers.

  15. Design and Development of Robot Hand System

    Directory of Open Access Journals (Sweden)

    Panchumarthy Seetharamaiah

    2011-01-01

    Full Text Available Research on robot hand design is being carried out to accommodate a variety of tasks such as grasping and manipulation of objects in the field of industrial applications, service robots and rehabilitation robots. Problem statement: To design and develop a microcontroller-based four fingered robotic hand with a simple and minimal control strategy to pick and place application with object detection by simple IR sensor logic. Approach: The methodology is based on anthropomorphic design with three fingers and an opposing thumb. Each finger has three links and three double revolute joints. Each finger is actuated by a single opposing pair of tendons. The robot hand system is interfaced to microcontroller with software control by means of 14 independent commands for the motion of joints: close and open for fore finger, middle finger, ring finger and thumb finger and wrist up and down, base clockwise and counter clockwise, pick and place and home position. The tendoning system and wireless feedback logic provide the hand with the ability to confirm to object topology and therefore providing the advantage of using a simple control structure. Results: Reliable grasping and releasing is achieved with simple control mechanisms and IR sensors/push-button switches. The hand can pick a variety of objects with different surface characteristics and shapes without having to reconstruct its surface description. Picking of the object is successfully completed as long as the object is within the workspace of the hand and placed the object at the desired position within the workspace by relevant software control using keyboard commands. Conclusion: Hardware and software development of microcontroller-based four-fingered robotic hand is addressed. Details of hand control software for mainly pick and place applications are presented. Results of the experimental work for pick and place application of different objects is enumerated.

  16. Cask systems development program seal technology

    Energy Technology Data Exchange (ETDEWEB)

    Madsen, M.M.; Edwards, K.R.; Humphreys, D.L.

    1991-01-01

    General design or test performance requirements for radioactive materials (RAM) packages are specified in Title 10 of the US Code of Federal Regulations Part 71 (10 CFR 71). Seals that provide the containment system interface between the packaging body and the closure must function in both high- and low-temperature environments under dynamic and static conditions. Experiments were performed to characterize the performance of several seal materials at low temperatures. Helium leak tests on face seals were used to compare the materials. Materials tested include butyl, neoprene, ethylene propylene, fuorosilicone, silicone, Eypel, Kalrez, Teflon, fluorocarbon, and Teflon/silicone composites. Results show that the seal materials tested, with the exception of silicone S613-60, are not leak tight at manufacturer low-temperature ratings. This paper documents the initial series of experiments developed to characterize the performance of several static seals under conditions representative of RAM transport container environments. Helium leak rates of face seals were measured at low and ambient temperatures to compare seal materials. As scaling laws have not been developed for seals, the leakage rates measured in this program are intended to be used in a qualitative rather than quantitative manner. 5 refs., 7 figs., 2 tabs.

  17. Development of the excretory system in a polyplacophoran mollusc: stages in metanephridial system development

    Directory of Open Access Journals (Sweden)

    Baeumler Natalie

    2012-09-01

    Full Text Available Abstract Background Two types of excretory systems, protonephridia and metanephridial systems are common among bilaterians. The homology of protonephridia of lophotrochozoan taxa has been widely accepted. In contrast, the homology of metanephridial systems – including coelomic cavities as functional units – among taxa as well as the homology between the two excretory systems is a matter of ongoing discussion. This particularly concerns the molluscan kidneys, which are mostly regarded as being derived convergently to the metanephridia of e.g. annelids because of different ontogenetic origin. A reinvestigation of nephrogenesis in polyplacophorans, which carry many primitive traits within molluscs, could shed light on these questions. Results The metanephridial system of Lepidochitona corrugata develops rapidly in the early juvenile phase. It is formed from a coelomic anlage that soon achieves endothelial organization. The pericardium and heart are formed from the central portion of the anlage. The nephridial components are formed by outgrowth from lateral differentiations of the anlage. Simultaneously with formation of the heart, podocytes appear in the atrial wall of the pericardium. In addition, renopericardial ducts, kidneys and efferent nephroducts, all showing downstream ciliation towards the internal lumen, become differentiated (specimen length: 0.62 mm. Further development consists of elongation of the kidney and reinforcement of filtration and reabsorptive structures. Conclusions During development and in fully formed condition the metanephridial system of Lepidochitona corrugata shares many detailed traits (cellular and overall organization with the protonephridia of the same species. Accordingly, we suggest a serial homology of various cell types and between the two excretory systems and the organs as a whole. The formation of the metanephridial system varies significantly within Mollusca, thus the mode of formation cannot be used

  18. Microelectromechanical Systems (MEMS) Broadband Light Source Developed

    Science.gov (United States)

    Tuma, Margaret L.

    2003-01-01

    A miniature, low-power broadband light source has been developed for aerospace applications, including calibrating spectrometers and powering miniature optical sensors. The initial motivation for this research was based on flight tests of a Fabry-Perot fiberoptic temperature sensor system used to detect aircraft engine exhaust gas temperature. Although the feasibility of the sensor system was proven, the commercial light source optically powering the device was identified as a critical component requiring improvement. Problems with the light source included a long stabilization time (approximately 1 hr), a large amount of heat generation, and a large input electrical power (6.5 W). Thus, we developed a new light source to enable the use of broadband optical sensors in aerospace applications. Semiconductor chip-based light sources, such as lasers and light-emitting diodes, have a relatively narrow range of emission wavelengths in comparison to incandescent sources. Incandescent light sources emit broadband radiation from visible to infrared wavelengths; the intensity at each wavelength is determined by the filament temperature and the materials chosen for the filament and the lamp window. However, present commercial incandescent light sources are large in size and inefficient, requiring several watts of electrical power to obtain the desired optical power, and they emit a large percentage of the input power as heat that must be dissipated. The miniature light source, developed jointly by the NASA Glenn Research Center, the Jet Propulsion Laboratory, and the Lighting Innovations Institute, requires one-fifth the electrical input power of some commercial light sources, while providing similar output light power that is easily coupled to an optical fiber. Furthermore, it is small, rugged, and lightweight. Microfabrication technology was used to reduce the size, weight, power consumption, and potential cost-parameters critical to future aerospace applications. This chip

  19. Development of a system of programs HAMMER - ORIGEN - 2 system

    International Nuclear Information System (INIS)

    The development of a system of programs (Hamor-2) to calculate precision inventory of LWR reactors is presented. The Hamor-2 code generates with the Hammer-technion code the four (4) energy groupe effective cross section of the actinides: U-235, U-236, U-238, Pu-239, Pu-240, Pu-241, Pu-242. Hamor-2 collapses the four group energy effective cross section to one group energy effective cross section. Hamor-2 calculates with origen-2 the new concentrations for the actinides using the one group energy effective cross section. Two PWR reactors were analised. (HBR, KWO). The discrepancy between the final actinides conentration results calculated by Hamor-2 and the results of measures finded in the references were calculated. That discrepancies have been compared with the discrepancy between : the final actinide concentration results calculated by Origen-2 and some measured results finded in the references. (E.G.)

  20. Development of blood extraction system for health monitoring system

    Science.gov (United States)

    Tsuchiya, Kazuyoshi; Nakanishi, Naoyuki; Nakamachi, Eiji

    2004-03-01

    The purpose of this research is to develop the compact human blood sampling device applied for a health monitoring system(HMS), which is called "Mobile Hospital". The HMS consists of (1) a micro electrical pumping system for blood extraction, (2) a bio-sensor to detect and evaluate an amount of Glucose, Cholesterol and Urea in extracted blood, by using enzyme such as Glucoseoxidase (GOD), Cholesteroloxidase and Urease. The mechanical design elements of the device are bio-compatible microneedle, indentation unit using a shape memory alloy(SMA) actuator and pumping unit using a piezoelectric microactuator. The design concept is the biomimetic micromachine of female mosquito"s blood sampling mechanism. The performances of the main mechanical elements such as indentation force of the microneedle, actual stroke of the indentation unit using a SMA actuator and liquid sampling ability of the pumping unit using PZT piezoelectric microactuator were measured. The 3 mm stroke of the indentation load generated by SMA actuator was 0.8mN. The amount of imitation blood extracted by using bimorph PZT actuators was about 0.5 microliters for 10 sec. A 60-micrometer outer diameter and 25-micrometer inner diameter Titanium microneedle, which size is same as female mosquito"s labium, was produced by sputter deposition.

  1. Development of the low energy linac systems

    International Nuclear Information System (INIS)

    The project 'Development of the Low Energy Linac System' is aiming to develop the 20 MeV proton linac system. This consists of a 50 keV proton injector, a 3 MeV RFQ, and a 20 MeV DTL. We obtained the first beam signal after the 20 MeV linac. The high power switch installed in the ion source supplies the pulsed beam into the following LEBT. The pulse operation was successfully tested. The main role of the LEBT is to match the beam into the 3 MeV RFQ. The total length of the four-vane type RFQ is about 3.26m. For the field stabilization, we used the resonant coupling scheme and dipole stabilizer rods. An 1 MW klystron supplies the RF power into the RFQ. After tuning, the field deviation of the quadrupole mode is less than 2% of the design value and the dipole fraction is less than 5% of the operating mode. The following accelerating structure is DTL which accelerate 20 mA proton beams up to 20 MeV. It consists of 4 tanks and the length of each tank is less than 5 m. The lattice is FFDD type and the integrated fields of the quadrupole magnets are 1.75 T. The inner walls of the tanks are copper-plated by PR plating method. The thickness is 100m with the roughness of 0.3m. Each drift tube consists of 6 parts and assembled by e-beam welding. The tanks and drift tubes are aligned under the installation limit of 50m by using the laser-tracker. The tuning by the slug tuners and post couplers results in the field uniformity of 2% and field sensitivity of 100%/MHz. In order to detect the beam signal, we installed the Faraday cup after the RFQ or the DTL. For the RFQ, we observed the beam of 12 A under the forward RF power of 450 kW. The beam current after DTL is about 0.5 A when RF power of 150 kW was fed into each tank

  2. Integrated System Health Management Development Toolkit

    Science.gov (United States)

    Figueroa, Jorge; Smith, Harvey; Morris, Jon

    2009-01-01

    This software toolkit is designed to model complex systems for the implementation of embedded Integrated System Health Management (ISHM) capability, which focuses on determining the condition (health) of every element in a complex system (detect anomalies, diagnose causes, and predict future anomalies), and to provide data, information, and knowledge (DIaK) to control systems for safe and effective operation.

  3. NASA's Space Launch System: Development and Progress

    Science.gov (United States)

    Honeycutt, John; Lyles, Garry

    2016-01-01

    NASA is embarked on a new era of space exploration that will lead to new capabilities, new destinations, and new discoveries by both human and robotic explorers. Today, the International Space Station (ISS), supported by NASA's commercial partners, and robotic probes, are yielding knowledge that will help make this exploration possible. NASA is developing both the Orion crew vehicle and the Space Launch System (SLS) that will carry out a series of increasingly challenging missions that will eventually lead to human exploration of Mars. This paper will discuss the development and progress on the SLS. The SLS architecture was designed to be safe, affordable, and sustainable. The current configuration is the result of literally thousands of trade studies involving cost, performance, mission requirements, and other metrics. The initial configuration of SLS, designated Block 1, will launch a minimum of 70 metric tons (t) into low Earth orbit - significantly greater capability than any current launch vehicle. It is designed to evolve to a capability of 130 t through the use of upgraded main engines, advanced boosters, and a new upper stage. With more payload mass and volume capability than any rocket in history, SLS offers mission planners larger payloads, faster trip times, simpler design, shorter design cycles, and greater opportunity for mission success. Since the program was officially created in fall 2011, it has made significant progress toward first launch readiness of the Block 1 vehicle in 2018. Every major element of SLS continued to make significant progress in 2015. The Boosters element fired Qualification Motor 1 (QM-1) in March 2015, to test the 5-segment motor, including new insulation, joint, and propellant grain designs. The Stages element marked the completion of more than 70 major components of test article and flight core stage tanks. The Liquid Engines element conducted seven test firings of an RS-25 engine under SLS conditions. The Spacecraft

  4. Wind Development on Tribal Lands

    Energy Technology Data Exchange (ETDEWEB)

    Ken Haukaas; Dale Osborn; Belvin Pete

    2008-01-18

    Background: The Rosebud Sioux Tribe (RST) is located in south central South Dakota near the Nebraska border. The nearest community of size is Valentine, Nebraska. The RST is a recipient of several Department of Energy grants, written by Distributed Generation Systems, Inc. (Disgen), for the purposes of assessing the feasibility of its wind resource and subsequently to fund the development of the project. Disgen, as the contracting entity to the RST for this project, has completed all the pre-construction activities, with the exception of the power purchase agreement and interconnection agreement, to commence financing and construction of the project. The focus of this financing is to maximize the economic benefits to the RST while achieving commercially reasonable rates of return and fees for the other parties involved. Each of the development activities required and its status is discussed below. Land Resource: The Owl Feather War Bonnet 30 MW Wind Project is located on RST Tribal Trust Land of approximately 680 acres adjacent to the community of St. Francis, South Dakota. The RST Tribal Council has voted on several occasions for the development of this land for wind energy purposes, as has the District of St. Francis. Actual footprint of wind farm will be approx. 50 acres. Wind Resource Assessment: The wind data has been collected from the site since May 1, 2001 and continues to be collected and analyzed. The latest projections indicate a net capacity factor of 42% at a hub height of 80 meters. The data has been collected utilizing an NRG 9300 Data logger System with instrumentation installed at 30, 40 and 65 meters on an existing KINI radio tower. The long-term annual average wind speed at 65-meters above ground level is 18.2 mph (8.1 mps) and 18.7 mph (8.4 mps) at 80-meters agl. The wind resource is excellent and supports project financing.

  5. Oral health care systems in developing and developed countries

    DEFF Research Database (Denmark)

    Kandelman, Daniel; Arpin, Sophie; Baez, Ramon J;

    2012-01-01

    ; these institutions or clinics may be equipped with the latest technical facilities. In developing countries, health services are mostly directed to provide emergency care only or interventions towards certain age group population. The most common diseases are dental caries and periodontal disease and frequently...... developed countries where the periodontal profile is also less than satisfactory. Despite the fact that in several developed countries there are advanced programmes oriented to periodontal disease treatments, the concern is related to the lack of preventive oriented treatments. According to data available...

  6. Development of European urban tourist systems

    OpenAIRE

    Jerković Senta

    2009-01-01

    Relationship between urban development and tourism is a significant process in Europe today. Development of tourism has caused many organizational changes in urban environment. In the middle of the 20th century cultural and historical heritage in the cities was impetus of development of tourism in European cities. Nowadays, in many European cities tourism is recognized as a mean of further economic development. Strategy of polycentricity, outlined in European spatial development perspective i...

  7. Innovation ways on research and technical development system

    International Nuclear Information System (INIS)

    This book tells US innovation ways for research and technical development system, which mentions meaning and conception of research and development systematization system structure with principle, technology and structure, meaning of system management of R and D, effectiveness of R and D system, optimal type of R and D system, form of R and D system and support system, location and communication of R and D, innovation way of R and D system with propel ways and feature and R and D system structure internationalization of R and D system and strategy case and R and D system in the U.S and Japan. 635

  8. Extended professional development for systemic curriculum reform

    Science.gov (United States)

    Kubitskey, Mary Elizabeth

    Education standards call for adopting inquiry science instruction. Successful adoption requires professional development (PD) to support teachers, increasing the need for research on PD. This dissertation examines the question: What is the influence of high quality, curriculum aligned, long-term group workshops and related practice on teacher learning? I focus on the following subquestions: (1) What is the influence of high quality, curriculum aligned, long-term, group workshops on teacher knowledge and beliefs? (2) What is the impact of the workshops on teacher practice? (3) What is the influence of practice on student response? (4) What is the impact of practice and student response on teacher knowledge and beliefs? I focus on an instance of PD nested within a long-term systemic change initiative, tracing eleven science teachers' learning from workshops and associated enactments. The data included pre and post-unit interviews (n=22), two post-workshop interviews (n=17), workshop observations (n=2), classroom observations (n=24) and student work (n=351). I used mixed-methods analysis. Quantitative analysis measured teacher learning by comparing pre and post-unit interview ratings. Qualitative components included two case study approaches: logic model technique and cross-case synthesis, examining teacher learning within and across teachers. The findings suggested a teacher-learning model incorporating PD, teacher knowledge, beliefs, practice and student response. PD impacts teachers' knowledge by providing teachers with new knowledge, adapting previous knowledge, or convincing them to value existing knowledge they chose not to use. The workshops can influence beliefs, providing teachers with confidence and motivation to adopt the practice. Beliefs can mediate how knowledge manifested itself in practice that, in turn, impacts students' response. Student response influences the teachers' beliefs, either reinforcing or motivating change. This teacher-learning model

  9. The development of KAERI management information system -First year: The development of manpower information management system-

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Shin Bok; Huh, Young Hwan; Lee, Jong Bok; Park, Soo Jin; Lee, Young Jae; Park, Yeon Sik; Jang, Deok Kyu; Park, Seung Deok; Kim, Jong Myeong [Korea Atomic Energy Res. Inst., Taejon (Korea, Republic of)

    1991-12-01

    The purpose of this report is to describe the implementation of the management information system for manpower. This job is the first year`s for development KAERI management information system. It is important to properly manage a manpower to cope with the external circumstances promptly and to maximize the productivity of the organization. This report aims at basic management of manpower and uses multimedia to keep abreast with the times and introduces the concept of GUI (Graphic User Interface) to user for ease access. (Author).

  10. The development of KAERI management information system -First year: The development of manpower information management system-

    International Nuclear Information System (INIS)

    The purpose of this report is to describe the implementation of the management information system for manpower. This job is the first year's for development KAERI management information system. It is important to properly manage a manpower to cope with the external circumstances promptly and to maximize the productivity of the organization. This report aims at basic management of manpower and uses multimedia to keep abreast with the times and introduces the concept of GUI (Graphic User Interface) to user for ease access. (Author)

  11. Diagnostics Systems for Permanent Hall Thrusters Development

    Science.gov (United States)

    Ferreira, Jose Leonardo; Soares Ferreira, Ivan; Santos, Jean; Miranda, Rodrigo; Possa, M. Gabriela

    This work describes the development of Permanent Magnet Hall Effect Plasma Thruster (PHALL) and its diagnostic systems at The Plasma Physics Laboratory of University of Brasilia. The project consists on the construction and characterization of plasma propulsion engines based on the Hall Effect. Electric thrusters have been employed in over 220 successful space missions. Two types stand out: the Hall-Effect Thruster (HET) and the Gridded Ion Engine (GIE). The first, which we deal with in this project, has the advantage of greater simplicity of operation, a smaller weight for the propulsion subsystem and a longer shelf life. It can operate in two configurations: magnetic layer and anode layer, the difference between the two lying in the positioning of the anode inside the plasma channel. A Hall-Effect Thruster-HET is a type of plasma thruster in which the propellant gas is ionized and accelerated by a magneto hydrodynamic effect combined with electrostatic ion acceleration. So the essential operating principle of the HET is that it uses a J x B force and an electrostatic potential to accelerate ions up to high speeds. In a HET, the attractive negative charge is provided by electrons at the open end of the Thruster instead of a grid, as in the case of the electrostatic ion thrusters. A strong radial magnetic field is used to hold the electrons in place, with the combination of the magnetic field and the electrostatic potential force generating a fast circulating electron current, the Hall current, around the axis of the Thruster, mainly composed by drifting electrons in an ion plasma background. Only a slow axial drift towards the anode occurs. The main attractive features of the Hall-Effect Thruster are its simple design and operating principles. Most of the Hall-Effect Thrusters use electromagnet coils to produce the main magnetic field responsible for plasma generation and acceleration. In this paper we present a different new concept, a Permanent Magnet Hall

  12. Small Drinking Water Systems Research and Development

    Science.gov (United States)

    In the United States, there are 152,002 public water systems (PWS) in operation. Of these, 97% are considered small systems under the Safe Drinking Water Act (SDWA)—meaning they serve 10,000 or fewer people. While many of these small systems consistently provide safe, relia...

  13. Enhancing System Realisation in Formal Model Development

    DEFF Research Database (Denmark)

    Tran-Jørgensen, Peter Würtz Vinther

    2016-01-01

    Software for mission-critical systems is sometimes analysed using formal specification to increase the chances of the system behaving as intended. When sufficient insights into the system have been obtained from the formal analysis, the formal specification is realised in the form of a software i...

  14. A decision support system for stress only myocardial perfusion scintigraphy may save unnecessary rest studies

    DEFF Research Database (Denmark)

    Tägil, K; Jakobsson, D; Lomsky, M;

    2013-01-01

    The aim of this study was to investigate the influence of a computer-based decision support system (DSS) on performance and inter-observer variability of interpretations regarding ischaemia and infarction in myocardial perfusion scintigraphy (MPS).......The aim of this study was to investigate the influence of a computer-based decision support system (DSS) on performance and inter-observer variability of interpretations regarding ischaemia and infarction in myocardial perfusion scintigraphy (MPS)....

  15. Integrated approach to optomechanical system development

    Science.gov (United States)

    Reney, Thomas E.; Wiggins, Richard L.; Comstock, Lovell E.; Santman, Jeffry J.; Woodard, Kenneth S.

    2011-06-01

    Over the past few decades of computer aided engineering growth there has been much more progress in increasing the power and capability of function specific engineering tools (e.g., optical design, finite element analysis, etc.) than in the integration of and communication between these tools. With only a few notable exceptions, such as FEA being imbedded into solid modeling, the communication method between the function specific tools continues to be dominated by translation to neutral data formats (e.g., IGES, STEP) and file transfer. There are a number of problems with this approach. The translation is a serial process where an engineer has to stop at some point in the design, make the neutral file, send that file to the next function, and wait for feedback. The translation through a neutral format is typically one way so the whole translation process has to be repeated when changes are required. Revision tracking of multiple files for each design iteration is both critical and a likely source of errors. Also, as with any translation, some information is always lost or corrupted in the process. This paper describes some progress that has been made in more tightly integrating optical design, mechanical design, fabrication, and testing of optical systems. Tools have been developed that connect CODE V®[1] to SolidWorks®[2] (bidirectional), compensation of diamond turning CNC from interferometric data, slope analysis from interferometer and profilometer data, and other tools for wavefront error compensation, and electronic nulls. Design, machining, testing and inspection efficiency gains are achieved through tools that consume mechanical solid models in their native format.

  16. Development of a PSA information management system

    Energy Technology Data Exchange (ETDEWEB)

    Ho, Seok; Dong Kyu, Kim; Sun Koo, Kang [Korea Power Engineering Company, Inc (Korea, Republic of)

    2007-07-01

    In general, Probabilistic Safety Agreement (PSA) is a very complicated work that uses and generates a lot of resources such as reports, procedures, drawings, assumptions, calculation sheets, PSA model, and so on. In many PSAs, however, the data, materials and knowledge considered and generated during performing PSA are scattered in many documents so that overall structure of PSA and information relationship between documents and models cannot easily be understood. To organize and manage all documents related to PSA, to capture knowledge of analysts, and finally to improve the quality of PSA, a PSA information management system (PIMS) was developed. The PIMS can manage all the documents of a PSA in a database and connect the causal relation between one information to another in the scattered documents via link. The PIMS can manage all the assumptions and technical basis used in PSA, and it can keep the record of the design changes the revision of PSA model. It can also control the review results of PSA models. The link of the PIMS can explicitly describe and reveal the expertise of the PSA analysts, and it enables the users to capture the knowledge and to understand the structure and contents of a PSA with ease. We are planning to apply the PIMS to the PSA of Shin Kori Units 1 and 2 as feasibility study and then to all the PSAs of the nuclear power plants in Korea. The PIMS is expected to contribute to enhancing the quality and confidence of PSA and reducing the efforts and costs of maintenance and update of PSA. (authors)

  17. Cultural Development through Human Resource Systems Integration.

    Science.gov (United States)

    Albert, Michael

    1985-01-01

    Discusses the framework for developing a cultural human resources management (HRM) perspective. Central to this framework is modifying HRM programs to reinforce the organization's preferred practices. Modification occurs through selection, orientation, training and development, performance appraisal, career development, and compensation and…

  18. Standardization of information systems development processes and banking industry adaptations

    OpenAIRE

    Tuna Ozcer; Zuhal Tanrikulu

    2011-01-01

    This paper examines the current system development processes of three major Turkish banks in terms of compliance to internationally accepted system development and software engineering standards to determine the common process problems of banks. After an in-depth investigation into system development and software engineering standards, related process-based standards were selected. Questions were then prepared covering the whole system development process by applying the classical Waterfall l...

  19. Development of a library for interprocess communication in interactive systems

    OpenAIRE

    ŠKVORC, URBAN

    2015-01-01

    The goal of the diploma thesis was to develop a simple and efficient interprocess communication system for the Linux operating system. The developed system gives developers a simple to use process for sharing information between multiple running processes. It uses a publish/subscribe model, which enables easier organization of messages. The developed system uses Linux sockets, which allow for efficient one-to-one data transfer. It is based on a central process which runs in the background and...

  20. GST Revisited: Working Systems Principles for Training and Development Consultants.

    Science.gov (United States)

    Owens, Elizabeth

    1990-01-01

    Presents seven principles for applying technology to training and development problems. Based on General Systems Theory (GST), these principles were developed to help with long-term decisions. Highlights include instructional systems development models; complexity in cultural systems; matching training materials to user characteristics; systems…

  1. Potential Development of Vehicle Traction Levitation Systems with Magnetic Suspension

    Directory of Open Access Journals (Sweden)

    A.V. Kireev

    2015-03-01

    Full Text Available Below is given the brief analysis of development trend for vehicle traction levitation systems with magnetic suspension. It is presented the assessment of potential development of traction levitation systems in terms of their simplicity. The examples are considered of technical solutions focused on reducing the complexity of transport systems. It is proposed the forecast of their further development.

  2. Development of white LED based PV lighting systems

    Energy Technology Data Exchange (ETDEWEB)

    Sastry, O.S.; Pant, P.C.; Prasad, G.; Kumar, Rajesh; Bandyopadhyay, Bibek [Solar Energy Centre, Ministry of New and Renewable Energy, Block 14, CGO Complex, Lodhi Road, New Delhi 110003 (India); Kamala Devi, V. [Agency for Non-Conventional Energy and Rural Technology, P.B. No. 1094, Pattom, P.O. Kasavadasapuram, Trivandrum, Kerala 695 004 (India)

    2010-09-15

    A high performance white light emitting diode (WLED) based PV lighting system has been developed under a joint project of SEC and ANERT. The system has been analyzed using the test set-ups developed as a part of advanced lighting laboratory (ALL). The results show that the performance is one of the best among the systems developed in the capacity range. (author)

  3. Development of Traction Drive Motors for the Toyota Hybrid System

    Science.gov (United States)

    Kamiya, Munehiro

    Toyota Motor Corporation developed in 2005 a new hybrid system for a large SUV. This system included the new development of a high-speed traction drive motor achieving a significant increase in power weight ratio. This paper provides an overview of the hybrid system, discusses the characteristics required of a traction drive motor, and presents the technologies employed in the developed motor.

  4. Systems design and engineering : facilitating multidisciplinary development projects

    NARCIS (Netherlands)

    Bonnema, G. Maarten; Veenvliet, Karel Th.; Broenink, Jan F.

    2016-01-01

    As its name implies, the aim of Systems Design and Engineering: Facilitating Multidisciplinary Development Projects is to help systems engineers develop the skills and thought processes needed to successfully develop and implement engineered systems. Such expertise typically does not come through st

  5. Potential Development of Vehicle Traction Levitation Systems with Magnetic Suspension

    OpenAIRE

    A.V. Kireev; N.M. Kozhemyaka; G.N. Kononov

    2015-01-01

    Below is given the brief analysis of development trend for vehicle traction levitation systems with magnetic suspension. It is presented the assessment of potential development of traction levitation systems in terms of their simplicity. The examples are considered of technical solutions focused on reducing the complexity of transport systems. It is proposed the forecast of their further development.

  6. Development of a Relational Database for Learning Management Systems

    Science.gov (United States)

    Deperlioglu, Omer; Sarpkaya, Yilmaz; Ergun, Ertugrul

    2011-01-01

    In today's world, Web-Based Distance Education Systems have a great importance. Web-based Distance Education Systems are usually known as Learning Management Systems (LMS). In this article, a database design, which was developed to create an educational institution as a Learning Management System, is described. In this sense, developed Learning…

  7. THE ISSUE OF A FUZZY EXPERT SYSTEM DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Laptev V. N.

    2015-12-01

    Full Text Available The article considers questions of the information system of choice of development tools of automated systems based on fuzzy logic model. The technique allows us to develop information systems in an objectoriented programming language. Information system allows selecting the most effective tool without additional researches

  8. Systems design methodology to develop chrysanthemum growing systems

    NARCIS (Netherlands)

    Blok, C.; Vermeulen, T.

    2012-01-01

    When chrysanthemum growers change soil for a soilless growing system they aim for labour cost reduction, quality and yield improvement and reduced emissions of nutrients. Because many attempts to come up with a viable soilless system failed, improvements and systemizations of the design process were

  9. Development of a Portable Muon Witness System

    Energy Technology Data Exchange (ETDEWEB)

    Aguayo Navarrete, Estanislao; Kouzes, Richard T.; Orrell, John L.

    2011-01-01

    Since understanding and quantifying cosmic ray induced radioactive backgrounds in copper and germanium are important to the MAJORANA DEMONSTRATOR, methods are needed for monitoring the levels of such backgrounds produced in materials being transported and processed for the experiment. This report focuses on work conducted at Pacific Northwest National Laboratory to develop a muon witness system as a one way of monitoring induced activities. The operational goal of this apparatus is to characterize cosmic ray exposure of materials. The cosmic ray flux at the Earth’s surface is composed of several types of particles, including neutrons, muons, gamma rays and protons. These particles induce nuclear reactions, generating isotopes that contribute to the radiological background. Underground, the main mechanism of activation is by muon produced spallation neutrons since the hadron component of cosmic rays is removed at depths greater than a few tens of meters. This is a sub-dominant contributor above ground, but muons become predominant in underground experiments. For low-background experiments cosmogenic production of certain isotopes, such as 68Ge and 60Co, must be accounted for in the background budgets. Muons act as minimum ionizing particles, depositing a fixed amount of energy per unit length in a material, and have a very high penetrating power. Using muon flux measurements as a “witness” for the hadron flux, the cosmogenic induced activity can be quantified by correlating the measured muon flux and known hadronic production rates. A publicly available coincident muon cosmic ray detector design, the Berkeley Lab Cosmic Ray Detector (BLCRD), assembled by Juniata College, is evaluated in this work. The performance of the prototype is characterized by assessing its muon flux measurements. This evaluation is done by comparing data taken in identical scenarios with other cosmic ray telescopes. The prototype is made of two plastic scintillator paddles with

  10. Developing a Small Business Regulatory System

    Directory of Open Access Journals (Sweden)

    Geoff Miller

    2014-09-01

    Full Text Available IntroductionThank you for inviting me to share my thoughts on what the government is doing to reduce the burden on small business. I also look forward to hearing the other speakers talk about how to make the regulatory system more responsive and relevant to business needs.It is more than a year since the fall of Lehman Brothers and the beginning of the Australian Government’s response to the global financial crisis.Today, the Australian economy is showing encouraging signs of recovery. The Government’s policy responses have been largely responsible for placing Australia in a better position than most countries around the world.The Mid-Year Economic and Fiscal Outlook (MYEFO (released earlier this month showed that the economy is performing much better than was forecast in the last Budget — MYEFO shows that Australia is the only advanced economy to have recorded positive growth through the year to June 2009. MYEFO also upgraded the growth forecasts for the following two years with consequental falls in the expected peak unemployment rate.Although this is good news, the GFC has clearly affected, and is continuing to impact on, small business.A number of Australian Chamber of Commerce and Industry surveys have reported large falls in small business confidence and conditions throughout 2008 and early 2009. However, the August ACCI Small Business Survey reports that, while conditions for small business are expected to remain challenging, conditions are stabilising.This good news is supported by the most recent Commonwealth Bank – ACCI Business Expectations Survey, which shows that small, medium and large businesses are expecting business conditions to improve significantly during this quarter.It is true that small businesses succeed or fail on the creativity, ingenuity, innovation and imagination of their owners and staff. It is also true that small businesses are notoriously time poor. When considering ways to improve the regulatory

  11. Development of a system for safety indicators

    International Nuclear Information System (INIS)

    This R and D effort was carried out to support the introduction of safety performance indicators (SPIs) for the SKI inspections. The main goal was to compile and evaluate indicators currently in use by the Swedish utilities, and those proposed by the SKI. The main parts of the work performed were: - a compilation of safety performance indicators used by the utilities and those proposed by the SKI; - an assessment of selected important attributes for each SPI; - a description of the data collection processes; - an evaluation of how the currently used SPIs cover the various focus areas of the SKI yearly safety performance assessments for the plants; - a proposal of which SPIs to use for the 2002 assessments; - participation in reference group meetings. The utilities have used SPIs since the early 1990s. SPIs are regularly calculated and presented at plants and at corporate offices, and the SPIs are today an integrated part of the management systems. The selection of SPIs is based both on the WANO SPIs and on SPIs defined by the users themselves. The compilation shows that the utilities currently use well over 20 SPIs for follow-up of safety at the plants, including all of the 8 WANO SPIs. A SKI pilot project has proposed a number of SPIs for internal use. The basis is the reporting requirements according to regulations in SKIFS 1998:1, with its barrier- and defence-in-depth principles. A first implementation is planned for the 2002 safety assessments of plant performance. The SKI has in the report proposed use of 9 groups of SPIs. Several are identical or similar to those used by the utilities. An analysis of the data extracted from the SKI LER database STAGBAS implies some quality assurance problems i.e. data are not easily re-created. The data base itself though should be well fit for the application. Users within the Vattenfall group perform various aggregations of the SPIs, while others so far have only presented indicator data for the individual SPIs. Several of

  12. 3rd International Workshop on Critical Systems Development with UML

    OpenAIRE

    Jan Jürjens; Eduardo B. Fernandez; Robert France; Bernhard Rumpe

    2016-01-01

    Topics of the Workshop include: --- Applications of UML to real-time systems security-critical systems dependable / safety-critical systems performance-critical systems embedded systems hybrid systems reactive systems --- Extensions of UML (UML-RT, UMLsec, Automotive UML, Embedded UML, ...) and new developments (UML 2.0, MDA) --- Modeling, synthesis, model transformation, code generation, testing, validation, and verification of critical systems using UML --- Aspect-oriented or Component-base...

  13. Information Systems: Current Developments and Future Expansion.

    Science.gov (United States)

    1970

    On May 20, 1970, a one-day seminar was held for Congressional members and staff. The papers given at this seminar and included in the proceedings are: (1) "Understanding Information Systems" by J. D. Aron, (2) "Computer Applications in Political Science" by Kenneth Janda, (3) "Who's the Master of Your Information System?" by Marvin Kornbluh, (4)…

  14. DEVELOPMENT OF A GENERIC RECOMMENDER SYSTEM

    Directory of Open Access Journals (Sweden)

    Dan Munteanu

    2004-12-01

    Full Text Available his paper presents a recommender system for textual documents taken from web (given as bookmarks. The system uses for classification a combination of content, event and collaborative filters and for recommendation a modified Pearson-r algorithm. It uses implicit and explicit feedback for evaluating documents.

  15. Developing Systemic Theories Requires Formal Methods

    Science.gov (United States)

    Gobet, Fernand

    2012-01-01

    Ziegler and Phillipson (Z&P) advance an interesting and ambitious proposal, whereby current analytical/mechanistic theories of gifted education are replaced by systemic theories. In this commentary, the author focuses on the pros and cons of using systemic theories. He argues that Z&P's proposal both goes too far and not far enough. The future of…

  16. Requirements development for a patient computing system.

    OpenAIRE

    Wald, J. S.; Pedraza, L. A.; Reilly, C. A.; Murphy, M. E.; Kuperman, G. J.

    2001-01-01

    Critical parts of the software development life cycle are concerned with eliciting, understanding, and managing requirements. Though the literature on this subject dates back for several decades, practicing effective requirements development remains a current and challenging area. Some projects flourish with a requirements development process (RDP) that is implicit and informal, but this approach may be overly risky, particularly for large projects that involve multiple individuals, groups, a...

  17. Land system science and sustainable development of the earth system

    DEFF Research Database (Denmark)

    Verburg, Peter H.; Crossman, Neville; Ellis, Erle C.;

    2015-01-01

    Land systems are the result of human interactions with the natural environment. Understanding the drivers, state, trends and impacts of different land systems on social and natural processes helps to reveal how changes in the land system affect the functioning of the socio-ecological system as a ...... be seen as the largest geo-engineering project in which mankind has engaged, land system science can act as a platform for integration of insights from different disciplines and for translation of knowledge into action....

  18. Marshall Space Flight Center Ground Systems Development and Integration

    Science.gov (United States)

    Wade, Gina

    2016-01-01

    Ground Systems Development and Integration performs a variety of tasks in support of the Mission Operations Laboratory (MOL) and other Center and Agency projects. These tasks include various systems engineering processes such as performing system requirements development, system architecture design, integration, verification and validation, software development, and sustaining engineering of mission operations systems that has evolved the Huntsville Operations Support Center (HOSC) into a leader in remote operations for current and future NASA space projects. The group is also responsible for developing and managing telemetry and command configuration and calibration databases. Personnel are responsible for maintaining and enhancing their disciplinary skills in the areas of project management, software engineering, software development, software process improvement, telecommunications, networking, and systems management. Domain expertise in the ground systems area is also maintained and includes detailed proficiency in the areas of real-time telemetry systems, command systems, voice, video, data networks, and mission planning systems.

  19. Towards a sustainable system of drug development

    NARCIS (Netherlands)

    Moors, Ellen H.M.; Cohen, Adam F.; Schellekens, Huub

    2014-01-01

    Drug development has become the exclusive activity of large pharmaceutical companies. However, the output of new drugs has been decreasing for the past decade and the prices of new drugs have risen steadily, leading to access problems for many patients. By analyzing the history of drug development a

  20. Embed XRF Data Processing System Development

    International Nuclear Information System (INIS)

    This paper introduced a project of XRF data processing system. The project adopted embed processor LPC2148 as the core of the data processing. This System has equipped graph LCD and the number of dots is 320 x 240. The large capacity Secure Digital Memory Card has been used as Data memory. It could exchange data with PC by USB interface. Also, we have made some amelioration on the function of XRF data processing. This system running stably, capability credibility and using conveniently, so it has good prospect of application and extension. (authors)

  1. Radioisotope Power Systems Technology Development Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Radioisotope Power Systems (RPS) is a multicenter, multiagency (with the Department of Energy (DOE)) program whose purpose is to manage the Science Mission...

  2. Developing Open Source System Expertise in Europe

    DEFF Research Database (Denmark)

    Nyborg, Mads; Gustafsson, Finn; Christensen, Jørgen Erik

    2011-01-01

    source software systems. In addition the program focuses on the students learning interpersonal skills, such as personal and professional skills, multidisciplinary teamwork, communication, communication in a foreign language and leadership. The target group consists of European engineering students who...

  3. Automatic Tracking Evaluation and Development System (ATEDS)

    Data.gov (United States)

    Federal Laboratory Consortium — The heart of the ATEDS network consists of four SGI Octane computers running the IRIX operating system and equipped with V12 hardware graphics to support synthetic...

  4. The Systems Engineering Process for Human Support Technology Development

    Science.gov (United States)

    Jones, Harry

    2005-01-01

    Systems engineering is designing and optimizing systems. This paper reviews the systems engineering process and indicates how it can be applied in the development of advanced human support systems. Systems engineering develops the performance requirements, subsystem specifications, and detailed designs needed to construct a desired system. Systems design is difficult, requiring both art and science and balancing human and technical considerations. The essential systems engineering activity is trading off and compromising between competing objectives such as performance and cost, schedule and risk. Systems engineering is not a complete independent process. It usually supports a system development project. This review emphasizes the NASA project management process as described in NASA Procedural Requirement (NPR) 7120.5B. The process is a top down phased approach that includes the most fundamental activities of systems engineering - requirements definition, systems analysis, and design. NPR 7120.5B also requires projects to perform the engineering analyses needed to ensure that the system will operate correctly with regard to reliability, safety, risk, cost, and human factors. We review the system development project process, the standard systems engineering design methodology, and some of the specialized systems analysis techniques. We will discuss how they could apply to advanced human support systems development. The purpose of advanced systems development is not directly to supply human space flight hardware, but rather to provide superior candidate systems that will be selected for implementation by future missions. The most direct application of systems engineering is in guiding the development of prototype and flight experiment hardware. However, anticipatory systems engineering of possible future flight systems would be useful in identifying the most promising development projects.

  5. An Interoperability Infrastructure for Developing Multidatabase Systems

    OpenAIRE

    Doğaç, Asuman; Özhan, Gökhan; Kılıç, Ebru; Özcan, Fatma; Nural, Sena; Sema

    1998-01-01

    A multidatabase system (MDBS) allows the users to simultaneously access autonomous, heterogeneous databases using a single data model and a query language. This provides for achieving interoperability among heterogeneous, federated DBMSs. In this paper, we describe the interoperability infrastructure of a multidatabase system, namely METU Interoperable DBMS (MIND). The architecture of MIND is based on OMG distributed object management model. It is implemented on top of a CORBA compl...

  6. An expert system for logistics force development

    OpenAIRE

    Chadwick, Robert Lawrence

    1987-01-01

    Approved for public release; distribution is unlimited The purpose of this research is to show the feasibility of an expert system to aid logistics planners in determining the types and numbers of logistics units needed to support corps contingency plans. The proposed system represents the domain knowledge of logistics planners as rules and uses backwards chaining to infer the types and numbers of logistics units needed. Next a chain of command, represented as a tree diagram...

  7. Development of biostereometric experiments. [stereometric camera system

    Science.gov (United States)

    Herron, R. E.

    1978-01-01

    The stereometric camera was designed for close-range techniques in biostereometrics. The camera focusing distance of 360 mm to infinity covers a broad field of close-range photogrammetry. The design provides for a separate unit for the lens system and interchangeable backs on the camera for the use of single frame film exposure, roll-type film cassettes, or glass plates. The system incorporates the use of a surface contrast optical projector.

  8. Development of a relational database management system

    OpenAIRE

    Ruiz, Anabel Natalia; Maldonado, Calixto; Martínez Spessot, Cesar Ignacio

    2003-01-01

    The studies of Relational Data Base Management Systems and Databases constitute nowadays a main tren of investigation in large businesses and universities of the entire world. The creation of a data base engine keeps being a challenge since there are aspects in which have not been achieved a final solution. Por example, the requeriments of storage of images, video, sound. etc. The purpuse of this project is to implement a Relational Database Manager System (RDBMS) and an Interpreter of Data Q...

  9. Discussion on Development Trend of Chinese Enterprises Information System

    Science.gov (United States)

    Gan, Xiao-Hong

    Chinese enterprises have constructed their information systems one after another for reducing production cost, improving working efficiency, and better adapting to the development of the information age as well as the market environment. This chapter analyzes the status quo of Chinese enterprise information system, states the reasons for driving the development of enterprise information system, and discusses the development trend of Chinese enterprise information system from many angles.

  10. Interpersonal Communication Relevance to Professional Development, in Social Systems

    OpenAIRE

    Manoela Popescu

    2013-01-01

    Professional development is a desideratum both the organization and for each employee, in part, and interpersonal communication is the means of safe fulfillment, especially in social systems. No matter what ways of professional development are chosen, organizations (considered as major social systems) works on communication processes. Moreover, social systems are at the same time, communication systems. As so, the importance of interpersonal communication in providing professional development...

  11. Radiation risks to the developing nervous system

    International Nuclear Information System (INIS)

    The present abstract book contains the abstracts of 23 papers presented at the meeting. They are dealing with the effect of pre- or postnatal irradiation on the brain morphology metabolism or development studied in mice, rats or rabbits. (MG)

  12. On the Development of College Student Information Management System

    OpenAIRE

    Jin Anjiang

    2015-01-01

    currently there exist severe fragmentation, different development standards, lack of sufficient support and other problems in the development of college student information management system. Therefore accelerating the development of student information management system is of necessity to improve universities’ management and administration efficiency. From the perspective of customers’ demands, the system should be designed and developed on the basis of Web Service by adopting B/S structure ...

  13. Developing Sustainable Spacecraft Water Management Systems

    Science.gov (United States)

    Thomas, Evan A.; Klaus, David M.

    2009-01-01

    It is well recognized that water handling systems used in a spacecraft are prone to failure caused by biofouling and mineral scaling, which can clog mechanical systems and degrade the performance of capillary-based technologies. Long duration spaceflight applications, such as extended stays at a Lunar Outpost or during a Mars transit mission, will increasingly benefit from hardware that is generally more robust and operationally sustainable overtime. This paper presents potential design and testing considerations for improving the reliability of water handling technologies for exploration spacecraft. Our application of interest is to devise a spacecraft wastewater management system wherein fouling can be accommodated by design attributes of the management hardware, rather than implementing some means of preventing its occurrence.

  14. Development of the STPX Spheromak System

    Science.gov (United States)

    Williams, R. L.; Clark, J.; Weatherford, C. A.

    2015-11-01

    The progress made in starting up the STPX Spheromak system, which is now installed at the Florida A&M University, is reviewed. Experimental, computational and theoretical activities are underway. The control system for firing the magnetized coaxial plasma gun and for collecting data from the diagnostic probes, based on LabView, is being tested and adapted. Preliminary results of testing the installed magnetic field probes, Langmuir triple probes, cylindrical ion probes, and optical diagnostics will be discussed. Progress in modeling this spheromak using simulation codes, such as NIMROD, will be discussed. Progress in investigating the use of algebraic topology to describe this spheromak will be reported.

  15. Development of machine interference system in industries

    Directory of Open Access Journals (Sweden)

    Rodina Veronika Igorevna

    2013-09-01

    Full Text Available The aim of this work is to improve the control effectiveness of cell-type system due to solving the problem of optimal allocation of labor force. An optimality criterion was created as a result of this work. It allows to characterize the operation of the system and choose the best option of its organization which has maximized output. The main sections of the work: 1 The main directions of queuing theory in the analysis of production processes; 2 Optimality criterion in the production task of queuing; 3 Determination of the optimal number of operators in production units.

  16. Development and Utilization of Space Fission Power Systems

    Science.gov (United States)

    Houts, Michael G.; Mason, Lee S.; Palac, Donald T.; Harlow, Scott E.

    2009-01-01

    Space fission power systems could enable advanced civilian space missions. Terrestrially, thousands of fission systems have been operated since 1942. In addition, the US flew a space fission system in 1965, and the former Soviet Union flew 33 such systems prior to the end of the Cold War. Modern design and development practices, coupled with 65 years of experience with terrestrial reactors, could enable the affordable development of space fission power systems for near-term planetary surface applications.

  17. Intercultural Development in the Romanian School System

    Science.gov (United States)

    Chircu, Elena Sorina; Negreanu, Mirela

    2010-01-01

    The present paper aims to briefly describe the manner in which intercultural education is perceived in the Romanian school system, as well as the solutions that are being proposed (mainly in the form of activities) for reconsidering and strengthening interculturality as a dimension of education. We report on the results of semi-structured…

  18. Relevance, Pertinence and Information System Development

    Science.gov (United States)

    Kemp, D. A.

    1974-01-01

    The difference between pertinence and relevance is discussed. Other pairs of terms and the differences between their members are examined, and the suggestion is made that such studies could increase our understanding of the theory of information systems, and thence lead to practical improvements. (Author)

  19. Beef Heifer Development Within Three Calving Systems

    Science.gov (United States)

    A 3-yr study was conducted to evaluate impacts of calving system, weaning age, and post-weaning management on growth and reproduction in beef heifers. Heifer calves (n=676) born in late winter (LW; avg birth date = Feb 7 ± 9 d) or early spring (ES; avg birth date Apr 3 ± 10 d) were weaned at 190- or...

  20. Development of land cadastral system in Ukraine

    OpenAIRE

    A. Bordyuzha

    2012-01-01

    The article gives reasonable prospects for usage of land cadastre information, it’s place and role in land management. Foreign experience in the land cadastre has been explored and analyzed. It is proposed to improve the information system of land resources to ensure effective environmentally-save land use.

  1. Mechanical systems development of integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Park, Keun Bae; Chang, M. H.; Kim, J. I.; Choi, S.; Kim, K. S.; Kim, T. W.; Jeong, K. H.; Kim, J. H.; Kim, Y. W.; Lee, G. M.

    1997-07-01

    While Korean nuclear reactor strategy seems to remain focused on the large capacity power generation, it is expected that demand of small and medium size reactor will arise for multi-purpose applications such as small capacity power generation, co-generation and sea water desalination. This in mind, survey has been made on the worldwide small and medium integral reactors under development. Reviewed are their technical characteristics, development status, design features, application plans, etc. For the mechanical design scope of work, the structural concept compatible with the characteristics and requirements of integral reactor has been established. Types of major components were evaluated and selected. Functional and structural concept, equipment layout and supporting concept within the reactor pressure vessel have also been established. Preliminary mechanical design requirements were developed considering the reactor lifetime, operation conditions, and the expected loading combinations. To embody the concurrent design approach, recent CAD technology and team engineering concept were evaluated. (author). 31 refs.,16 tabs., 35 figs.

  2. Effects of lethal and non-lethal malaria on the mononuclear phagocyte system

    OpenAIRE

    Carlos Eduardo Tosta; Greta Ruiz; Nina Wedderburn

    1983-01-01

    The effects ofone non-lethal species ofmalarialparasite, Plasmodium yoelii, and one lethal species, P. berghei, on the mononuclear phagocyte system (MPS) of BALB/c mice were studied. P. yoelii caused a greater and more sustained expansion and activation of the MPS, and the two major populations of spleen phagocytic cells-red pulp and marginal zone macrophages - exhibited a greater increase in numbers in this infection. During the course of P. berghei mataria, the spleen was progressively occu...

  3. Developing a Frame of Reference for understanding configuration systems

    DEFF Research Database (Denmark)

    Ladeby, Klaes Rohde; Edwards, Kasper

    2008-01-01

    This paper uses the theory of technical systems to develop a frame of reference of product configuration systems. Following a definition of the configuration task, product model and product configuration system the theory of technical systems are presented. Configuration systems are then related...... to the theory of technical systems and it is shown that it is possible to understand configuration systems in this context. By doing so the configuration system is expanded to include human system. Three operators of the technical system are identified and analyzed. In this perspective it is realized that users...

  4. The Olig family affects central nervous system development and disease

    Institute of Scientific and Technical Information of China (English)

    Botao Tan; Jing Yu; Ying Yin; Gongwei Jia; Wei Jiang; Lehua Yu

    2014-01-01

    Neural cell differentiation and maturation is a critical step during central nervous system devel-opment. The oligodendrocyte transcription family (Olig family) is known to be an important factor in regulating neural cell differentiation. Because of this, the Olig family also affects acute and chronic central nervous system diseases, including brain injury, multiple sclerosis, and even gliomas. Improved understanding about the functions of the Olig family in central nervous system development and disease will greatly aid novel breakthroughs in central nervous system diseases. This review investigates the role of the Olig family in central nervous system develop-ment and related diseases.

  5. What the Current System Development Trends tell us about Systems Development Methodologies: Toward explaining SSDAM, Agile and IDEF0 Methodologies

    Directory of Open Access Journals (Sweden)

    Abdulla F. Ally

    2015-03-01

    Full Text Available Systems integration, customization and component based development approach are of increasing attention. This trend facilitates the research attention to also focus on systems development methodologies. The availability of systems development tools, rapid change in technologies, evolution of mobile computing and the growth of cloud computing have necessitated a move toward systems integration and customization rather than developing systems from scratch. This tendency encourages component based development and discourages traditional systems development approach. The paper presents and evaluates SSADM, IDEF0 and Agile systems development methodologies. More specifically, it examines how they fit or not fit into the current competitive market of systems development. In the view of this perspective, it is anticipated that despite of its popularity, SSADM methodology is becoming obsolete while Agile and IDEF0 methodologies are still gaining acceptance in the current competitive market of systems development. The present study more likely enrich our understanding of the systems development methodologies concepts and draw attention regarding where the current trends in system development are heading.

  6. The Development of a Lifelong Guidance System in Hungary

    Science.gov (United States)

    Watts, A. G.; Borbely-Pecze, Bors Tibor

    2011-01-01

    The development of a lifelong guidance system in Hungary Systematic work is currently being undertaken in Hungary to develop a lifelong guidance system, in line with principles outlined by leading international organisations. The origins of career guidance in Hungary, and the nature of the current career guidance system, are outlined. The main…

  7. Specifics of the Ecological Management System Development in Forestry

    OpenAIRE

    P.V. Kravets

    2011-01-01

    Specific of the development of ecological management system in forest was analyzed. It is ascertain that in spite of dissemination of functional standards all forest certification scheme consists some systemic requirements which provide creating of ecological management framework. Noncompliance in forestry management caused by undeveloped of the systemic elements of management. Proposals for the future development of forest certification were prepared.

  8. Developing a Credit Recognition System for Chinese Higher Education Institutions

    Science.gov (United States)

    Li, Fuhui

    2015-01-01

    In recent years, a credit recognition system has been developing in Chinese higher education institutions. Much research has been done on this development, but it has been concentrated on system building, barriers/issues and international practices. The relationship between credit recognition system reforms and democratisation of higher education…

  9. Development and innovation on integrated engineering optics system design

    Science.gov (United States)

    Ding, Quanxin; Liu, Hua; Zhou, Liwei

    2010-10-01

    Answer the new challenge in project research and development on multiple subjects multiple domain, engineering optics, system design and essential methods applied to structure effective system. Base on system engineering theory, traditional optical design optimization is developed. General global optimization, which based on central optics system integrated with up-to-date comprehensive modules and methods in created way, is presented and supported by abundant results of research and development, especially on multiple configuration and adaptive system optimization. Advantages such as system intellect, response ability, research periods, venture eluding and compatibility for renew situations demonstrate validity and potential.

  10. Rollover: a methodology for restraint system development

    NARCIS (Netherlands)

    Altamore, P.F.; Ridella, S.A.; Nayef, A.

    2001-01-01

    Concern about crash conditions other than frontal and side crashes has accelerated restraint development with respect to rollover events. Previous analysis of rollover field data indicates the high probability of ejection and consequent serious injury or death to unbelted occupants. Partial ejection

  11. Biocatalytic process development using microfluidic miniaturized systems

    DEFF Research Database (Denmark)

    Krühne, Ulrich; Heintz, Søren; Ringborg, Rolf Hoffmeyer;

    2014-01-01

    The increasing interest in biocatalytic processes means there is a clear need for a new systematic development paradigm which encompasses both protein engineering and process engineering. This paper argues that through the use of a new microfluidic platform, data can be collected more rapidly and...

  12. Geographic Information Systems and Web Page Development

    Science.gov (United States)

    Reynolds, Justin

    2004-01-01

    The Facilities Engineering and Architectural Branch is responsible for the design and maintenance of buildings, laboratories, and civil structures. In order to improve efficiency and quality, the FEAB has dedicated itself to establishing a data infrastructure based on Geographic Information Systems, GIS. The value of GIS was explained in an article dating back to 1980 entitled "Need for a Multipurpose Cadastre" which stated, "There is a critical need for a better land-information system in the United States to improve land-conveyance procedures, furnish a basis for equitable taxation, and provide much-needed information for resource management and environmental planning." Scientists and engineers both point to GIS as the solution. What is GIS? According to most text books, Geographic Information Systems is a class of software that stores, manages, and analyzes mapable features on, above, or below the surface of the earth. GIS software is basically database management software to the management of spatial data and information. Simply put, Geographic Information Systems manage, analyze, chart, graph, and map spatial information. GIS can be broken down into two main categories, urban GIS and natural resource GIS. Further still, natural resource GIS can be broken down into six sub-categories, agriculture, forestry, wildlife, catchment management, archaeology, and geology/mining. Agriculture GIS has several applications, such as agricultural capability analysis, land conservation, market analysis, or whole farming planning. Forestry GIs can be used for timber assessment and management, harvest scheduling and planning, environmental impact assessment, and pest management. GIS when used in wildlife applications enables the user to assess and manage habitats, identify and track endangered and rare species, and monitor impact assessment.

  13. Expert systems development utilizing heuristic methods.

    OpenAIRE

    Lewis, John N.

    1996-01-01

    Approved for public release; distribution is unlimited. This thesis analyzes the diagnostic domain and isolates the heuristics employed by experts to arrive at diagnostic solutions. These heuristic methods are then generalized in order to arrive at a series of heuristic rules that can be applied to a wide range of diagnostic processes independent of there respective domain. To test the validity of the generalized heuristics, a prototype expert system was created targeting th...

  14. Development of an autonomous target tracking system

    Science.gov (United States)

    Gidda, Venkata Ramaiah

    In recent years, surveillance and border patrol have become one of the key research areas in UAV research. Increase in the computational capability of the computers and embedded electronics, coupled with compatibility of various commercial vision algorithms and commercial off the shelf (COTS) embedded electronics, and has further fuelled the research. The basic task in these applications is perception of environment through the available visual sensors like camera. Visual tracking, as the name implies, is tracking of objects using a camera. The process of autonomous target tracking starts with the selection of the target in a sequence of video frames transmitted from the on-board camera. We use an improved fast dynamic template matching algorithm coupled with Kalman Filter to track the selected target in consecutive video frames. The selected target is saved as a reference template. On the ground station computer, the reference template is overlaid on the live streaming video from the on-board system, starting from the upper left corner of the video frame. The template is slid pixel by pixel over the entire source image. A comparison of the pixels is performed between the template and source image. A confidence value R of the match is calculated at each pixel. Based on the method used to perform the template matching, the best match pixel location is found according to the highest or lowest confidence value R. The best match pixel location is communicated to the on-board gimbal controller over the wireless Xbee network. The software on the controller actuates the pan-tilt servos to continuously to hold the selected target at the center of the video frame. The complete system is a portable control system assembled from commercial off the shelf parts. The tracking system is tested on a target having several motion patterns.

  15. Energy systems Diagnosis in developing countries

    International Nuclear Information System (INIS)

    Energy systems diagnosis is necessary to allow evaluation of energy balance by administration and political authorities of a country. First, the author describes the principle stages of energetic diagnosis. Then this work is divided into three parts: First part: Energy consumption diagnosis in several districts (families, utilities, agriculture, transport, industry) Second part: Energy supplies diagnosis (energy markets). Third part: Interactions between energy consumption and energy supply. 28 figs.; 52 tabs.; 107 refs

  16. Development of a capacitive bioimpedance measurement system

    OpenAIRE

    Gómez Abad, Daniel

    2009-01-01

    Bioelectrical impedance spectroscopy (BIS) is a well-established and non-invasive method to determine and monitor body composition. Commercially available bioelectrical impedance systems use coated hydrogel-aluminium electrodes, where the hydrogel acts as an adhesive and as an electrolytic medium. The gel/adhesive is physiologically inert over short periods. However, when used over longer periods, hydrogel-aluminium electrodes present limitations, which capacitive electrodes ma...

  17. Development process for secure mobile grid systems.

    OpenAIRE

    García Rosado, David

    2009-01-01

    Grid computing arises as an evolution of distributed systems mainly focused on the sharing and remote access to resources in a uniform, transparent, secure, efficient and reliable way. It is a new computation paradigm, a shared model that allows not only communication and storage but also information processing throughout the world. Although it was first used in the research and academic fields, Grid computing has rapidly emerged as the method used by corporate enterprises to collaborate, sha...

  18. Development of Palmprint Verification System Using Biometrics

    Institute of Scientific and Technical Information of China (English)

    G. Shobha; M. Krishna; S.C. Sharma

    2006-01-01

    Palmprint verification system using Biometrics is one of the emerging technologies, which recognizes a person based on the principle lines, wrinkles and ridges on the surface of the palm. These line structures are stable and remain unchanged throughout the life of an individual. More importantly, no two palmprints from different individuals are the same, and normally people do not feel uneasy to have their palmprint images taken for testing. Therefore palmprint recognition offers a promising future for medium-security access control systems. In this paper, a new approach for personal authentication using hand images is discussed. Gray-Scale palm images are captured using a digital camera at a resolution of 640′480. Each of these gray-scale images is aligned and then used to extract palmprint and hand geometry features. These features are then used for authenticating users. The image acquisition setup used here is inherently simple and it does not employ any special illumination nor does it use any pegs that might cause any inconvenience to users. Experimental results show that the designed system achieves an acceptable level of performance.

  19. Development of advanced PWR system analysis technology

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Y. D.; Kim, S. O.; Jung, B. D.; Kim, Y. I.; Chang, M. H.; Lee, Y. J.; Yun, J. H.

    1997-12-31

    The scope of this project is to establish the basic analysis technologies for the advanced designed with the passive and inherent safety concepts. The scope is extended to the application of these technologies to the performance and safety analysis of the passive reactor. Since the different design concepts are applied depending on the reactor power, the study is conducted for the small and medium sized integral reactor as well as the large scale passive reactors by focusing on the analysis technology development for the passive components. The design concepts which can be applied for the safety enhancement of the domestic advanced reactor are developed through evaluating the technical information of the overseas advanced reactor concepts.

  20. Implementing Life Cycle Assessment in systems development

    DEFF Research Database (Denmark)

    Bhander, Gurbakhash Singh; Hauschild, Michael Zwicky; McAloone, Timothy Charles

    2003-01-01

    of the barriers to implementation of LCA by developers of products, and of the opportunities for introducing environmental criteria in the design process through meeting the information requirements of the designer on the different life cycle stages, producing an in-depth understanding of the attitudes......Today's industry is being forced to consider the environmental performance of its products concurrently with traditional requirements such as quality, price or functional performance. The Life Cycle Assessment (LCA) technique has been identified as a powerful tool to calculate environmental impacts...... and the rapid changes in markets for many products. The overall aim of the paper is to provide an understanding of the environmental issues involved in the early stages of product development and the capacity of life cycle assessment techniques to address these issues. The paper aims to outline the problems...

  1. Development of Water Based Pesticide System

    Directory of Open Access Journals (Sweden)

    Slavica Gašić

    2012-01-01

    Full Text Available It is well known that emulsifiable concentrates (EC, besides good properties have problemwith a high solvent content thus are not environmental friendly and can cause problemsfor users. The interest in developing oil-in-water emulsions (EW instead emulsifiableconcentrates is increasing due to toxicological problems with solvents. Oil-in-water emulsionscan reduce phytotoxicity, ecotoxicity and dermal toxicity, have a higher flash pointthan EC and are safer in transport and storage; also EW are more compatible with waterbased SC formulations for blends of active ingredients. Plant protection often includes theuse of some pyretroides as active ingredients, for example Cypermethrin, alone or combinedwith Chlorpyrifos. It is a very old product which is formulated as EC formulation. Inthis study oil-in-water emulsion (EW was developed with the same active ingredients. TheEW formulation was tested and the results show that it was stable and therefore could beused in plant protection.

  2. The system of regional development monitoring indicators...

    OpenAIRE

    Oleg FRUNZE

    2016-01-01

    The effectiveness of the plan policies and proposals should be monitored in combination with an other environmental, social and economic monitoring in an integrated way. It is the cumulative effects of change in the area that should be the principal object of monitoring. Monitoring should be focused on reducing uncertainty, measuring the success of policies in helping to meet objectives, eliminating unsustainable forms of development, etc.

  3. Development of water based pesticide system

    OpenAIRE

    Slavica Gašić; Dragica Brkić; Ljiljana Radivojević; Anđelka Tomašević

    2012-01-01

    It is well known that emulsifiable concentrates (EC), besides good properties have problem with a high solvent content thus are not environmental friendly and can cause problems for users. The interest in developing oil-in-water emulsions (EW) instead emulsifiable concentrates is increasing due to toxicological problems with solvents. Oil-in-water emulsions can reduce phytotoxicity, ecotoxicity and dermal toxicity, have a higher flash point than EC and are ...

  4. Shuttle Transportation System Case-Study Development

    Science.gov (United States)

    Ransom, Khadijah

    2012-01-01

    A case-study collection was developed for NASA's Space Shuttle Program. Using lessons learned and documented by NASA KSC engineers, analysts, and contractors, decades of information related to processing and launching the Space Shuttle was gathered into a single database. The goal was to provide educators with an alternative means to teach real-world engineering processes and to enhance critical thinking, decision making, and problem solving skills. Suggested formats were created to assist both external educators and internal NASA employees to develop and contribute their own case-study reports to share with other educators and students. Via group project, class discussion, or open-ended research format, students will be introduced to the unique decision making process related to Shuttle missions and development. Teaching notes, images, and related documents will be made accessible to the public for presentation of Space Shuttle reports. Lessons investigated included the engine cutoff (ECO) sensor anomaly which occurred during mission STS-114. Students will be presented with general mission infom1ation as well as an explanation of ECO sensors. The project will conclude with the design of a website that allows for distribution of information to the public as well as case-study report submissions from other educators online.

  5. Developing a Small Business Regulatory System

    OpenAIRE

    Geoff Miller

    2014-01-01

    IntroductionThank you for inviting me to share my thoughts on what the government is doing to reduce the burden on small business. I also look forward to hearing the other speakers talk about how to make the regulatory system more responsive and relevant to business needs.It is more than a year since the fall of Lehman Brothers and the beginning of the Australian Government’s response to the global financial crisis.Today, the Australian economy is showing encouraging signs of recovery. The Go...

  6. Standardization of information systems development processes and banking industry adaptations

    CERN Document Server

    Tanrikulu, Zuhal

    2011-01-01

    This paper examines the current system development processes of three major Turkish banks in terms of compliance to internationally accepted system development and software engineering standards to determine the common process problems of banks. After an in-depth investigation into system development and software engineering standards, related process-based standards were selected. Questions were then prepared covering the whole system development process by applying the classical Waterfall life cycle model. Each question is made up of guidance and suggestions from the international system development standards. To collect data, people from the information technology departments of three major banks in Turkey were interviewed. Results have been aggregated by examining the current process status of the three banks together. Problematic issues were identified using the international system development standards.

  7. Merged PiN Schottky Diodes:A New Power Switching Diode%碳化硅MPS:新一代功率开关二极管

    Institute of Scientific and Technical Information of China (English)

    苗永斌; 张玉明; 张义门

    2004-01-01

    碳化硅MPS(Merged PiN Schottky diode)具有很好的开关特性,并具有PiN二极管高阻断电压、低漏电流和SBD小开启电压,大导通电流以及高开关速度的优点,是最有希望的新一代功率开关二极管.文章系统地介绍了碳化硅MPS的结构和性能.理论和实验分析表明,碳化硅材料的优异性能与MPS结构的优势相结合,是当今功率开关管发展的趋势.

  8. Mechanical properties of self-compacting concrete state-of-the-art report of the RILEM technical committee 228-MPS on mechanical properties of self-compacting concrete

    CERN Document Server

    Schutter, Geert

    2014-01-01

    The State-of-the-Art Report of RILEM Technical Committee 228-MPS on Mechanical properties of Self-Compacting Concrete (SCC) summarizes an extensive body of information related to mechanical properties and mechanical behaviour of SCC. Due attention is given to the fact that the composition of SCC varies significantly. A wide range of  mechanical properties are considered, including compressive strength, stress-strain relationship, tensile and flexural strengths, modulus of elasticity, shear strength, effect of elevated temperature, such as fire spalling and residual properties after fire, in-situ properties, creep, shrinkage, bond properties, and structural behaviour. A chapter on fibre-reinforced SCC is included, as well as a chapter on specialty SCC, such as light-weight SCC, heavy-weight SCC, preplaced aggregate SCC, special fibre reinforced SCC, and underwater concrete.

  9. Applying Sustainable Systems Development Approach to Educational Technology Systems

    Science.gov (United States)

    Huang, Albert

    2012-01-01

    Information technology (IT) is an essential part of modern education. The roles and contributions of technology to education have been thoroughly documented in academic and professional literature. Despite the benefits, the use of educational technology systems (ETS) also creates a significant impact on the environment, primarily due to energy…

  10. Study on Korean Radiological Emergency System-Care System- and National Nuclear Emergency Preparedness System Development

    International Nuclear Information System (INIS)

    Care system; Radiological Emergency Supporting System. Environmental radiology level is the main aspect that should be concerned deal with the utilization of nuclear energy. The usage of informational technology in nuclear area gives significant contribution to anticipate and to protect human and environment. Since 1960, South Korea has developed environment monitoring system as the effort to protect the human and environment in the radiological emergency condition. Indonesia has possessed several nuclear installations and planned to build and operate nuclear power plants (PLTN) in the future. Therefore, Indonesia has to prepare the integrated system, technically enables to overcome the radiological emergency. Learning from the practice in South Korea, the system on the radiological emergency should be prepared and applied in Indonesia. However, the government regulation draft on National Radiological Emergency System, under construction, only touches the management aspect, not the technical matters. Consequently, when the regulation is implemented, it will need an additional regulation on technical aspect including the consideration on the system (TSS), the organization of operator and the preparation of human resources development of involved institution. For that purpose, BAPETEN should have a typical independence system in regulatory frame work. (author)

  11. Solar heating and cooling system design and development

    Science.gov (United States)

    1979-01-01

    The design and development of marketable solar heating and cooling systems for single family and commercial applications is described. The delivery, installation, and monitoring of the prototype systems are discussed. Seven operational test sites are discussed in terms of system performance. Problems encountered with equipment and installation were usually due to lack of skills required for solar system installation.

  12. Development of a New-type Sweating Manikin System

    Institute of Scientific and Technical Information of China (English)

    LI Jun; WANG Yun-yi; ZHANG Wei-yuan; CHEN Yi-song; LI Xue-dong

    2006-01-01

    A new type of sweating manikin system has been developed to evaluate thermal insulation and moisture evaporative resistance of clothing, which is reliable, easy control and low cost. In this paper the manikin system was reported and discussed from the aspects of system construction, work principles, figure formation, simulated sweating system,and technical properties.

  13. Development of an integrated data acquision system for research vessels

    Digital Repository Service at National Institute of Oceanography (India)

    Mehra, P.; Desai, R.G.P.

    This article describes an integrated data acquisition system (IDAS) designed and developed for multi-oceanographic research vessels. The prime motivation was to provide a flexible system, which could be used in the context of ocean related...

  14. SYSTEM OF MARKETING: PRINCIPLES OF FORMING, FUNCTIONING AND DEVELOPMENT

    OpenAIRE

    Mazko, T.

    2010-01-01

    Initial positions of system marketing forming, functioning and development are examined as a component subsystem to the enterprise. Principles are offered in relation to the certain states of the system of marketing for enterprise

  15. The Information Security Management System, Development and Audit

    OpenAIRE

    Surcel, Traian; Cristian AMANCEI

    2007-01-01

    Information security management system (ISMS) is that part of the overall management system, based on a business risk approach, that it is developed in order to establish, implement, operate, monitor, review, maintain and improve information security

  16. Recent Developments in the System Ortocartan

    Science.gov (United States)

    Krasiński, Andrzej

    2002-12-01

    This communication presents developments done after the previous published description. The following new programs exist now: Calculating the kinematic tensors of the flow and their evolution equations. Calculating the curvature tensor corresponding to given connection coefficients in any number of dimensions. Calculating the Lagrangian for a given metric by the Landau-Lifshitz prescription. Calculating the Euler-Lagrange equations from a given Lagrangian. Verifying first integrals for sets of ordinary differential equations of second order. Factoring out a given factor F in intermediate expressions. Conveniences. Availability.

  17. Subject, Object and Target Systems of Rural Human Resource Development

    OpenAIRE

    Shen, Hong; Zhao, Yong-le; Huang, De-bing

    2012-01-01

    From subject, object and target subsystems, we analyze the rural human resource development system. The subject system includes government, education and training organizations, society, and rural human resource itself. Different development subject bears different responsibility. Object system includes farmers engaged in farming, farmer workers, rural unemployed people, rural students, rural left-behind people, and other people in rural areas. Different development object has different featu...

  18. Controlled Ecological Life Support System: Research and Development Guidelines

    Science.gov (United States)

    Mason, R. M. (Editor); Carden, J. L. (Editor)

    1982-01-01

    Results of a workshop designed to provide a base for initiating a program of research and development of controlled ecological life support systems (CELSS) are summarized. Included are an evaluation of a ground based manned demonstration as a milestone in CELSS development, and a discussion of development requirements for a successful ground based CELSS demonstration. Research recommendations are presented concerning the following topics: nutrition and food processing, food production, waste processing, systems engineering and modelling, and ecology-systems safety.

  19. New Trends in the Development of Computerized Statistical Information Systems

    OpenAIRE

    Dujnic, P.

    1982-01-01

    This paper is one of a set of background and research papers for the study of information systems for regional planning. The spatial dimension of information systems as a decision aid in regional development planning has too often been neglected. Therefore, much more attention should be paid to the design and development of information systems reflecting socio-economic processes, so as to arrive at a better representation of regional systems and a better adaptation to the needs of regional pl...

  20. Development of the Field of Flexible AC Transmission Systems (FACTS)

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    @@ Theoretical and technological development of large capacity power electronics and flexible AC transmission systems are one of the most important projects developed by Tsinghua University. The Flexible AC Transmission System (FACTS) technology which uses power electronics to improve the efficiency and quality of the electrical generation, transmission and distribution system is considered to be one of the most significant technological innovations for power systems in the 20th century. The advanced static var generator (ASVG) is a key FACTS device.

  1. Policy Driven Development: Flexible Policy Insertion for Large Scale Systems

    OpenAIRE

    Demchak, Barry; Krüger, Ingolf

    2012-01-01

    The success of a software system depends critically on how well it reflects and adapts to stakeholder requirements. Traditional development methods often frustrate stakeholders by creating long latencies between requirement articulation and system deployment, especially in large scale systems. One source of latency is the maintenance of policy decisions encoded directly into system workflows at development time, including those involving access control and feature set selection.

  2. Developing Performance-Centered Systems for Higher Education

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The experience in developing performance-centered systems for higher education has improved significantly, and practitioners have made considerable progress in elaborating a methodology. This paper discusses the convergence of thinking among various disciplines in analysis and design methodologies, and describes the key elements of the new-emerged performance support engineering development methodology. These are important for designing web-based systems, information systems, and knowledge management systems in higher education.

  3. Adolescent development of the reward system

    Directory of Open Access Journals (Sweden)

    Adriana Galván

    2010-02-01

    Full Text Available Adolescence is a developmental period characterized by increased reward-seeking behavior. Investigators have used functional magnetic resonance imaging (fMRI in conjunction with reward paradigms to test two opposing hypotheses about adolescent developmental changes in the striatum, a region implicated in reward processing. One hypothesis posits that the striatum is relatively hypo-responsive to rewards during adolescence, such that heightened reward-seeking behavior is necessary to achieve the same activation as adults. Another view suggests that during adolescence the striatal reward system is hyper-responsive, which subsequently results in greater reward-seeking. While evidence for both hypotheses has been reported, the field has generally converged on this latter hypothesis based on compelling evidence. In this review, I describe the evidence to support this notion, speculate on the disparate fMRI findings and conclude with future areas of inquiry to this fascinating question.

  4. A Holistic Approach to Systems Development

    Science.gov (United States)

    Wong, Douglas T.

    2008-01-01

    Introduces a Holistic and Iterative Design Process. Continuous process but can be loosely divided into four stages. More effort spent early on in the design. Human-centered and Multidisciplinary. Emphasis on Life-Cycle Cost. Extensive use of modeling, simulation, mockups, human subjects, and proven technologies. Human-centered design doesn t mean the human factors discipline is the most important Disciplines should be involved in the design: Subsystem vendors, configuration management, operations research, manufacturing engineering, simulation/modeling, cost engineering, hardware engineering, software engineering, test and evaluation, human factors, electromagnetic compatibility, integrated logistics support, reliability/maintainability/availability, safety engineering, test equipment, training systems, design-to-cost, life cycle cost, application engineering etc. 9

  5. ADP and brucellosis indemnity systems development

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, W.M.; Harlan, B.L.

    1976-01-01

    Our initial study of the USDA/TAHC Brucellosis Indemnity Program in Texas has shown that both the efficiency and rate of claim payments can be increased by the application of present day computer technologies. Two main factors contribute to these increases: the number of discrepancies that are caused by poor penmanship, transposition of numbers, and other human errors can be monitored and minimized; and the documented information can be indexed, sorted, and searched faster, more efficiently, and without human error. The overall flow of documentation that is used to control the movement of infected or exposed animals through commerce should be studied. A new system should be designed that fully utilizes present day computer and electronic technologies.

  6. Interpersonal Communication Relevance to Professional Development, in Social Systems

    Directory of Open Access Journals (Sweden)

    Manoela Popescu

    2013-04-01

    Full Text Available Professional development is a desideratum both the organization and for each employee, in part, and interpersonal communication is the means of safe fulfillment, especially in social systems. No matter what ways of professional development are chosen, organizations (considered as major social systems works on communication processes. Moreover, social systems are at the same time, communication systems. As so, the importance of interpersonal communication in providing professional development is major, proven fact, at least in one sense, by the rich offer of training courses focusing on communication. Moreover, analysis of case studies of interpersonal communication conducted in organizational context indicates that the communication is purpose, means and professional development tool.

  7. Guiding the development of a controlled ecological life support system

    Science.gov (United States)

    Mason, R. M. (Editor); Carden, J. L. (Editor)

    1979-01-01

    The workshop is reported which was held to establish guidelines for future development of ecological support systems, and to develop a group of researchers who understand the interdisciplinary requirements of the overall program.

  8. Development of nuclear reaction data retrieval system on Meme media

    International Nuclear Information System (INIS)

    A newly designed retrieval system of charged particle nuclear reaction data is developed on Meme media architecture. We designed the network-based (client-server) retrieval system. The server system is constructed on a UNIX workstation with a relational database, and the client system is constructed on Microsoft Windows PC using an IntelligentPad software package. The IntelligentPad is currently available as developing Meme media. We will develop the system to realize effective utilization of nuclear reaction data: I. 'Re-production, Re-edit, Re-use', II. 'Circulation, Coordination and Evolution', III. 'Knowledge discovery'. (author)

  9. The development of component-based information systems

    CERN Document Server

    Cesare, Sergio de; Macredie, Robert

    2015-01-01

    This work provides a comprehensive overview of research and practical issues relating to component-based development information systems (CBIS). Spanning the organizational, developmental, and technical aspects of the subject, the original research included here provides fresh insights into successful CBIS technology and application. Part I covers component-based development methodologies and system architectures. Part II analyzes different aspects of managing component-based development. Part III investigates component-based development versus commercial off-the-shelf products (COTS), includi

  10. Increased IgG on cell-derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation

    DEFF Research Database (Denmark)

    Nielsen, Christoffer T; Østergaard, Ole; Stener, Line;

    2012-01-01

    To quantify immunoglobulin and C1q on circulating cell-derived microparticles (MPs) in patients with systemic lupus erythematosus (SLE) and to determine whether immunoglobulin and C1q levels are correlated with clinical and serologic parameters.......To quantify immunoglobulin and C1q on circulating cell-derived microparticles (MPs) in patients with systemic lupus erythematosus (SLE) and to determine whether immunoglobulin and C1q levels are correlated with clinical and serologic parameters....

  11. Low energy beam transport system developments

    Science.gov (United States)

    Dudnikov, V.; Han, B.; Stockli, M.; Welton, R.; Dudnikova, G.

    2015-04-01

    For high brightness beam production it is important to preserve the brightness in the low energy beam transport system (LEBT) used to transport and match the ion beams to the next stage of acceleration, usually an RFQ. While electrostatic focusing can be problematic for high current beam transport, reliable electrostatic LEBT operation has been demonstrated with H- beams up to 60 mA. Now, however, it is commonly accepted that an optimal LEBT for high current accelerator applications consists of focusing solenoids with space charge compensation. Two-solenoid LEBTs are successfully used for high current (>100 mA) proton beam transport. Preservation of low emittances (~0.15 π mm-mrad) requires the addition of a heavy gas (Xe, Kr), which causes ~5% of proton loss in a 1 m long LEBT. Similar Xe densities would be required to preserve low emittances of H- beams, but such gas densities cause unacceptably high H- beam losses. A short LEBT with only one short solenoid, movable for RFQ matching, can be used for reduced negative ion stripping. A strong electrostatic-focusing LEBT has been successfully adopted for transport of high current H- beams in the SNS Front End. Some modifications of such electrostatic LEBTs are expected to improve the reliable transport of intense positive and negative ion beams without greatly degrading their low emittances. We concentrate on processes that determine the beam brightness degradation and on their prevention. Proposed improvements to the SNS electrostatic LEBT are discussed.

  12. Proposed Reactor Operating Experience Feedback System Development

    International Nuclear Information System (INIS)

    Most events occurring in nuclear power plants are not individually significant, and prevented from progressing to accident conditions by a series of barriers against core damage and radioactive releases. Significant events, if occur, are almost always a breach of these multiple barriers. As illustrated in the 'Swiss cheese' model, the individual layers of defense or 'cheese slices' have weakness or 'holes.' These weaknesses are inconstant, i.e., the holes are open or close at random. When by chance all the holes are aligned, a hazard causes the significant event of concern. Elements of low significant events, inattention to detail, time or economic pressure, uncorrected poor practices/habits, marginal maintenance and equipment care, etc., make holes in the layers of defense; some elements may make more holes in different layers, incurring more chances to be aligned. An effective reduction of the holes, therefore, is gained through better knowledge or awareness of increasing trends of the event elements, followed by appropriate actions. According to the Swiss cheese metaphor, attention to the Operating Experience (OE) feedback system, as opposed to the individual and to randomness, is drawn from a viewpoint of reactor safety

  13. Traditional versus Agile: The Tragile Framework for Information Systems Development

    Directory of Open Access Journals (Sweden)

    Mohammed S. Seyam

    2011-01-01

    Full Text Available Traditional systems development methodologies sometimes fall short in today?s business environments because they lack the flexibility required for most of today?s information systems projects. In response to this problem, so called "Agile" software development methodologies have been proposed and put to use. Although agile development appeared as a way to overcome the limitations of the traditional development methodologies, they faced some challenges when applied in specific problem domains. The concept of agility, which emphasizes human role in software development processes, is revolutionizing the systems analysis and design field as well as the software engineering field. However, the question that begs an answer is whether traditional systems development methodologies have no place in today?s fastpaced developments. This paper demonstrates the extent to which agile software development methodologies can be combined with traditional approaches to information systems development, showing the advantages of combining agile and traditional approaches in the same project. The paper then proposes the "Tragile" framework, which is a hybrid framework that combines both traditional and agile development practices to serve the field of information systems development. The paper then presents a summary of a case study application to show how the Tragile framework had affected the development process in the selected project.

  14. Development of HANARO Activation Analysis System and Utilization Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Y. S.; Moon, J. H.; Cho, H. J. (and others)

    2007-06-15

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility.

  15. Development of HANARO Activation Analysis System and Utilization Technology

    International Nuclear Information System (INIS)

    1. Establishment of evaluation system using a data for a neutron activation analysis : Improvement of NAA measurement system and its identification, Development of combined data evaluation code of NAA/PGAA, International technical cooperation project 2. Development of technique for a industrial application of high precision gamma nuclide spectroscopic analysis : Analytical quality control, Development of industrial application techniques and its identification 3. Industrial application research for a prompt gamma-ray activation analysis : Improvement of Compton suppression counting system (PGAA), Development of applied technology using a PGAA system 4. Establishment of NAA user supporting system and KOLAS management : Development and validation of KOLAS/ISO accreditation testing and identification method, Cooperation researches for a industrial application, Establishment of integrated user analytical supporting system, Accomplishment of sample irradiation facility

  16. Help for the Developers of Control System Cyber Security Standards

    Energy Technology Data Exchange (ETDEWEB)

    Robert P. Evans

    2008-05-01

    A Catalog of Control Systems Security: Recommendations for Standards Developers (Catalog), aimed at assisting organizations to facilitate the development and implementation of control system cyber security standards, has been developed. This catalog contains requirements that can help protect control systems from cyber attacks and can be applied to the Critical Infrastructures and Key Resources of the United States and other nations. The requirements contained in the catalog are a compilation of practices or various industry bodies used to increase the security of control systems from both physical and cyber attacks. They should be viewed as a collection of recommendations to be considered and judiciously employed, as appropriate, when reviewing and developing cyber security standards for control systems. The recommendations in the Catalog are intended to be broad enough to provide any industry using control systems the flexibility needed to develop sound cyber security standards specific to their individual security requirements.

  17. Photovoltaics. [research and development of terrestrial electric power systems

    Science.gov (United States)

    Smith, J. L.

    1981-01-01

    The federal government has sponsored a program of research and development on terrestrial photovoltaic systems that is designed to reduce the costs of such systems through technological advances. There are many potential paths to lower system costs, and successful developments have led to increased private investment in photovoltaics. The prices for photovoltaic collectors and systems that appear to be achievable within this decade offer hope that the systems will soon be attractive in utility applications within the United States. Most of the advances achieved will also be directly applicable to the remote markets in which photovoltaic systems are now commercially successful

  18. Developing a System Architecture for Holonic Shop Floor Control

    DEFF Research Database (Denmark)

    Sørensen, Christian; Langer, Gilad; Alting, Leo

    1998-01-01

    This paper describes the results of research regarding the emerging theory of Holonic Manufacturing Systems. This theory and in particular its corresponding reference architecture serves as the basis for the development of a system-architecture for shop floor control systems in a multi-cellular c......This paper describes the results of research regarding the emerging theory of Holonic Manufacturing Systems. This theory and in particular its corresponding reference architecture serves as the basis for the development of a system-architecture for shop floor control systems in a multi...

  19. Development of BSCCO persistent current system

    Energy Technology Data Exchange (ETDEWEB)

    Joo, Jin Ho; Nah, Wan Soo; Kang, Hyung Koo; Yoo, Jung Hoon [Sungkyunkwan University, Seoul (Korea)

    1998-05-01

    We have developed temperature-variable critical current measurement device for high Tc superconducting wires. For this end, vacuum shroud was designed and fabricated, and that both signal lines and power lines into the vacuum shroud were installed on it. Secondly, the design procedures for the PCS were established for the high Tc superconducting wires based on the electrical circuit analyses during energizations. We have also evaluated mechanical properties such as hardness, strength and elongation of sheath alloys made by addition of Cu, Mg, Ti, Zr and Ni to Ag matrix using induction melting furnace. It was observed that hardness and strength were improved by increasing additive contents from 0.05 to 0.2 at.%. Specifically, the increment of strength was relatively higher for alloys made by addition of Mg, Cu and Zr elements than that made by Ni and Ti addition. On the other hand, elongation was measured to be significantly reduced for former sheath alloy materials. (author). 12 refs., 13 figs., 4 tabs.

  20. Human development and sustainability of energy systems

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This seminar on human development and sustainability was jointly organized by the French agency of environment and energy mastery (Ademe) and Enerdata company. This document summarises the content of the different presentations and of the minutes of the discussions that took place at the end of each topic. The different themes discussed were: 1 - Political and methodological issues related to sustainability (sustainability concept in government policy, sustainability and back-casting: lessons from EST); 2 - towards a socially viable world: thematic discussions (demography and peoples' migration; time budget and life style change - equal sex access to instruction and labour - geopolitical regional and inter-regional universal cultural acceptability; welfare, poverty and social link and economics); 3 - building up an environmentally sustainable energy world, keeping resources for future generations and preventing geopolitical ruptures (CO{sub 2} emissions; nuclear issues; land-use, noise, and other industrial risks). The memorandum on sustainability issues in view of very long term energy studies is reprinted in the appendix. The transparencies of seven presentations are attached to this document. (J.S.)