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Sample records for system ibs version

  1. Integrated Baseline System (IBS) Version 1.03: Utilities guide

    Energy Technology Data Exchange (ETDEWEB)

    Burford, M.J.; Downing, T.R.; Pottier, M.C.; Schrank, E.E.; Williams, J.R.

    1993-01-01

    The Integrated Baseline System (IBS) is an emergency management planning and analysis tool that was developed under the direction of the Federal Emergency Management Agency (FEMA). This Utilities Guide explains how to operate utility programs that are supplied as a part of the IBS. These utility programs are chiefly for managing and manipulating various kinds of IBS data and system administration files. Many of the utilities are for creating, editing, converting, or displaying map data and other data that are related to geographic location.

  2. Integrated Baseline System (IBS) Version 2.0: Utilities Guide

    Energy Technology Data Exchange (ETDEWEB)

    Burford, M.J.; Downing, T.R.; Williams, J.R. [Pacific Northwest Lab., Richland, WA (United States); Bower, J.C. [Bower Software Services, Kennewick, WA (United States)

    1994-03-01

    The Integrated Baseline System (IBS) is an emergency management planning and analysis tool being developed under the direction of the US Army Nuclear and Chemical Agency. This Utilities Guide explains how you can use the IBS utility programs to manage and manipulate various kinds of IBS data. These programs include utilities for creating, editing, and displaying maps and other data that are referenced to geographic location. The intended audience for this document are chiefly data managers but also system managers and some emergency management planners and analysts.

  3. Integrated Baseline System (IBS) Version 2.0: Models guide

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    The Integrated Baseline System (IBS) is an emergency management planning and analysis tool being developed under the direction of the US Army Nuclear and Chemical Agency. This Models Guide summarizes the IBS use of several computer models for predicting the results of emergency situations. These include models for predicting dispersion/doses of airborne contaminants, traffic evacuation, explosion effects, heat radiation from a fire, and siren sound transmission. The guide references additional technical documentation on the models when such documentation is available from other sources. The audience for this manual is chiefly emergency management planners and analysts, but also data managers and system managers.

  4. Data Management Guide: Integrated Baseline System (IBS). Version 2.1

    Energy Technology Data Exchange (ETDEWEB)

    Bower, J.C. [Bower Software Services, Kennewick, Washington (United States); Burford, M.J.; Downing, T.R.; Moise, M.C.; Williams, J.R. [Pacific Northwest Lab., Richland, WA (United States)

    1995-01-01

    The Integrated Baseline System (IBS) is an emergency management planning and analysis tool that is being developed under the direction of the US Army Nuclear and Chemical Agency (USANCA). The IBS Data Management Guide provides the background, as well as the operations and procedures needed to generate and maintain a site-specific map database. Data and system managers use this guide to manage the data files and database that support the administrative, user-environment, database management, and operational capabilities of the IBS. This document provides a description of the data files and structures necessary for running the IBS software and using the site map database.

  5. Integrated Baseline Bystem (IBS) Version 1.03: Models guide

    Energy Technology Data Exchange (ETDEWEB)

    1993-01-01

    The Integrated Baseline System)(IBS), operated by the Federal Emergency Management Agency (FEMA), is a system of computerized tools for emergency planning and analysis. This document is the models guide for the IBS and explains how to use the emergency related computer models. This document provides information for the experienced system user, and is the primary reference for the computer modeling software supplied with the system. It is designed for emergency managers and planners, and others familiar with the concepts of computer modeling. Although the IBS manual set covers basic and advanced operations, it is not a complete reference document set. Emergency situation modeling software in the IBS is supported by additional technical documents. Some of the other IBS software is commercial software for which more complete documentation is available. The IBS manuals reference such documentation where necessary.

  6. Flexibility of Supply Chain in Industrialised Building System (IBS

    Directory of Open Access Journals (Sweden)

    Kassim U.

    2014-01-01

    Full Text Available It is irrefutable that the construction industry is in need of a highly technological construction method or system for the simple aim of giving it a push it deserves. In Malaysia this technologically enhanced method is known as the Indutrialised Building System (IBS. Concerted efforts have been made for the past decade by various responsible parties especially by the government. Therefore, the IBS ‘Road Map’ 2003–2010 was introduced and now continues with the IBS ‘road map’ 2011-2015. However, its performance is still at its infancy, which target is only at an initial stage. This study seeks to identify and analyse the factor of the IBS’ system’s supply chain flexibility as a factor on the success of the system itself. It has been a suspicion that there exists a condition and situation where the supply chain is too rigid and is not flexible in fulfilling the needs and demands of the IBS development in Malaysia. This inflexible situation has brought about a broad range of problems and has stood in the way of the development of the industrialised building system, despite it being introduced since 1964, or 49 years ago. Flexibility in the IBS supply chain is very important and is associated with other industries like transportation, manufacturing industry, and others. Up until now, we have yet to discover any special studies related to the flexibility in the IBS supply chain in this country. Responding to this challenge, this research is hoped to be able to provide sufficient feedback to the solution to the IBS supply chain flexibility issue. The researcher is confident that the poor system flow of supply chain has impeded the advancement of the Industrialised Building System that has long been open to debate.

  7. FRAGMENTATION ISSUE IN MALAYSIAN INDUSTRIALISED BUILDING SYSTEM (IBS PROJECTS

    Directory of Open Access Journals (Sweden)

    MOHD NASRUN MOHD NAWI

    2014-02-01

    Full Text Available As a developing country, Malaysian is currently driving for implementing a new or modern construction method, the Industrialised Building System (IBS, as an alternative towards enhancing construction performance. Currently, most of the IBS project developments in Malaysia are still conducted by using the traditional construction process approach. This traditional construction process has been widely criticised for its fragmented approach to project delivery and its failure to form effective teams thus created a number of issues such as reworks, time delay, rising costs, lack of communication and coordination, and wastages. This paper through literature review aims to highlight this fragmentation issue and clarify how far it affects the process of IBS implementation. Suggestions on how an integrated approach in design and construction in order to minimise the fragmentation gaps will be concluded.

  8. Translation and validation of a Japanese version of the irritable bowel syndrome-quality of life measure (IBS-QOL-J

    Directory of Open Access Journals (Sweden)

    Hongo Michio

    2007-03-01

    Full Text Available Abstract Aims To compare quality of life (QOL for patients with irritable bowel syndrome (IBS between the U.S. and Japan, it is indispensable to develop common instruments. The IBS-QOL, which is widely used in Western countries, was translated into Japanese as there has been a lack of Japanese disease-specific QOL measures for IBS. Methods The original 34 items of the IBS-QOL were translated from English into Japanese through two independent forward translations, resolution, back translation, and resolution of differences. Forty nine patients who had GI symptoms but did not have any organic diseases (including 30 IBS patients diagnosed by Rome II criteria were recruited from Tohoku University Hospital in Sendai, Japan and completed a Japanese version of the IBS-QOL (IBS-QOL-J concomitant with a Japanese version of the IBS severity index (IBSSI-J twice within 7–14 days. Results The IBS-QOL-J demonstrated high internal consistency (Cronbach's alpha; 0.96 and high reproducibility (intraclass correlation coefficient; 0.92, p Conclusion The IBS-QOL-J is a reliable instrument to assess the disease-specific QOL for IBS. Considering cross-cultural comparison, this measure is likely to be a valuable tool to investigate the QOL in Japanese patients with IBS.

  9. Validity, reliability, and factor analysis of Persian version of quality of life questionnaire for irritable bowel syndrome (IBS-QOL-34

    Directory of Open Access Journals (Sweden)

    Nasrine Masaeli

    2013-01-01

    Full Text Available Background: Quality of life (QOL improvement is the main objective of treating patients with irritable bowel syndrome (IBS. This study aimed to assess the validity, reliability, and factor analysis of IBS-QOL-34 questionnaire as a common transcultural instrument for Iranian IBS patients. Materials and Methods: Two hundred and forty patients with IBS (based on gastroenterologists′ diagnosis according to ROM III criteria were referred to Digestive Health Clinic in Psychosomatic Research Center have been selected in this study. Aside with IBS-QOL-34, MOS 36-item short-form health survey (SF-36 and IBS severity index (IBSSI questionnaires were completed by the cases for determination of correlation coefficients; the data were analyzed using descriptive statistics, factor analysis, Cronbach′s alpha, Pearson correlation coefficient by Statistical Package for Social Sciences (SPSS software, version 18. Results: Total reliability of the questionnaire was reported by using Cronbach′s alpha as 0.95, ranging from 0.65 to 0.90. Correlation coefficients of concurrent implementation of IBS-QOL with SF-36 and IBSSI resulted in −0.61 and 0.64, respectively. Exploratory factor analysis using varimax rotation identified eight principle components, which will determine QOL at 67% variance. Conclusion: According to the results, IBS-QOL-34 questionnaire has good psychometric properties in the research community and can be safely used as a valid tool to assess QOL of patients with IBS for healthcare and therapeutic purposes.

  10. IBS SURVEY 2010: DRIVERS, BARRIERS AND CRITICAL SUCCESS FACTORS IN ADOPTING INDUSTRIALISED BUILDING SYSTEM (IBS CONSTRUCTION BY G7 CONTRACTORS IN MALAYSIA

    Directory of Open Access Journals (Sweden)

    KAMARUL ANUAR MOHAMAD KAMAR

    2014-08-01

    Full Text Available The industrialised building system (IBS survey has become an essential tool for ensuring the IBS Roadmap (2003 to 2010 meets its goals and target. As part of the process review survey, it also records the trend achievement of Malaysia in the usage of IBS in the building construction industry. The first and second IBS surveys were published in 2003 and 2005, respectively. Afterward, the IBS Roadmap’s midterm review was conducted. The third and the most recent IBS surveys were conducted in 2008 and 2010, respectively. This paper aims to highlight a part of the IBS survey report in 2010, which has been conducted to measure the drivers, barriers and the critical success factors of G7 contractors in adopting IBS construction. G7 is a Construction Industry Development Board contractor grade that can apply tender without limit. The importance of this paper is that it guides the policy and implementation strategy of IBS by G7 contractors. The survey shows that the acceptance, adoption, and deployment of IBS in the Malaysian construction industry are still low and do not address the persisting problems, such as productivity, dependency on foreign workers and high level of construction wastage.

  11. The Insight of Industrialised Building System (IBS By Bumiputera Construction Players

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    Muhammad W. M. N. W.

    2016-01-01

    Full Text Available The term Industrialised Building System (IBS is widely recognised by construction players in Malaysia since its first implementation since 1960s for IBS pilot projects of Pekeliling Flats and Rifle Range Flats. The aim for the implementation is to promote better system in delivering construction end-products which offers efficiency and effectiveness. At the same time, Bumiputera construction players are the majority of parties in construction industry especially in Small and Medium Enterprises (SMEs. Therefore, the purpose of this paper is to identify the perception and awareness of IBS implementation among Bumiputera players. It is found that, Bumiputera construction players have sound knowledge on the IBS and optimistic towards further implementation for future projects. Nonetheless, issues on payment methods and coordination of IBS project delivery are found to be the negative perceptions which are considered as hindrance for Bumiputera construction players’ involvement in IBS project.

  12. Advantages and Setbacks of Industrialized Building System (IBS) Implementation: A Case Study in Sarawak

    OpenAIRE

    Sing Sing Wong; Ling Kung Lau

    2015-01-01

    Industrialized Building System (IBS) is an innovative technique adopted to increase the efficiency, quality and productivity of projects. However, these advantages are proven mainly for projects located in urban areas only. IBS is not a common practice for projects located in rural areas. Although there were studies about IBS in Malaysia about its advantages and setbacks, these studies were focusing on projects located in urban areas located in West Malaysia only. Hence, this paper aids to cl...

  13. The Significance of Coordination for Industrialised Building System (IBS) Precast Concrete in Construction Industry

    OpenAIRE

    Fitri Othman Mohd Khairul; Wan Muhammad Wan Mohd Nurdden; Abd Hadi Nurulhudaya; Azman Mohd Azrai

    2017-01-01

    IBS precast concrete is construction system which is meant to improve the conventional construction process. However IBS precast concrete projects are suffering from serious problems such as cost overrun, delays and less quality of the end product. The absence of coordination is perceived as the reason for this issue. The purpose of this paper is to review the significance of coordination for IBS precast concrete in the construction industry. It if found that the fragmentation which occurs in...

  14. [Validation of the IBS-SSS].

    Science.gov (United States)

    Betz, C; Mannsdörfer, K; Bischoff, S C

    2013-10-01

    Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterised by abdominal pain, associated with stool abnormalities and changes in stool consistency. Diagnosis of IBS is based on characteristic symptoms and exclusion of other gastrointestinal diseases. A number of questionnaires exist to assist diagnosis and assessment of severity of the disease. One of these is the irritable bowel syndrome - severity scoring system (IBS-SSS). The IBS-SSS was validated 1997 in its English version. In the present study, the IBS-SSS has been validated in German language. To do this, a cohort of 60 patients with IBS according to the Rome III criteria, was compared with a control group of healthy individuals (n = 38). We studied sensitivity and reproducibility of the score, as well as the sensitivity to detect changes of symptom severity. The results of the German validation largely reflect the results of the English validation. The German version of the IBS-SSS is also a valid, meaningful and reproducible questionnaire with a high sensitivity to assess changes in symptom severity, especially in IBS patients with moderate symptoms. It is unclear if the IBS-SSS is also a valid questionnaire in IBS patients with severe symptoms because this group of patients was not studied. © Georg Thieme Verlag KG Stuttgart · New York.

  15. Post-Infectious IBS (IBS-PI)

    Science.gov (United States)

    ... for IBS Signs and Symptoms Overview Recognizing Symptoms Diagnosis of IBS Pain in IBS IBS with Constipation Constipated Diarrhea IBS ... for IBS Signs and Symptoms Overview Recognizing Symptoms Diagnosis of IBS Pain in IBS IBS with Constipation Constipated Diarrhea IBS ...

  16. Medications (for IBS)

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    Full Text Available ... IBS Pain in IBS IBS with Constipation Constipated Diarrhea IBS with Diarrhea Nausea and IBS Bloating in IBS Sleep and ... IBS Pain in IBS IBS with Constipation Constipated Diarrhea IBS with Diarrhea Nausea and IBS Bloating in ...

  17. Long‐Term Monitoring of a Geosynthetic Reinforced Soil Integrated Bridge System (GRS‐IBS)

    Science.gov (United States)

    2017-11-01

    The geosynthetic reinforced soil integrated bridge system (GRS-IBS) is an innovative alternative to conventional bridge technology that utilizes closely spaced layers of geosynthetic reinforcement and compacted granular fill material to provide direc...

  18. Medications (for IBS)

    Medline Plus

    Full Text Available ... IBS? What is IBS? Facts About IBS Gut Bacteria and IBS IBS in Men Other Disorders Testing ... IBS? What is IBS? Facts About IBS Gut Bacteria and IBS IBS in Men Other Disorders Testing ...

  19. Medications (for IBS)

    Medline Plus

    Full Text Available ... Can Use Living With IBS Relationships and IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience ... Can Use Living With IBS Relationships and IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience ...

  20. Medications (for IBS)

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    Full Text Available ... With IBS Relationships and IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience and Unmet Needs ... With IBS Relationships and IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience and Unmet Needs ...

  1. Medications (for IBS)

    Medline Plus

    Full Text Available ... is IBS? What is IBS? Facts About IBS Gut Bacteria and IBS IBS in Men Other Disorders ... is IBS? What is IBS? Facts About IBS Gut Bacteria and IBS IBS in Men Other Disorders ...

  2. Medications (for IBS)

    Medline Plus

    Full Text Available ... Diagnosis of IBS Pain in IBS IBS with Constipation Constipated Diarrhea IBS with Diarrhea Nausea and IBS ... Diagnosis of IBS Pain in IBS IBS with Constipation Constipated Diarrhea IBS with Diarrhea Nausea and IBS ...

  3. Medications (for IBS)

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    Full Text Available ... IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience and Unmet Needs IBS and Holidays Personal ... IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience and Unmet Needs IBS and Holidays Personal ...

  4. Critical Success Factors for Lean Thinking in the Application of Industrialised Building System (IBS)

    Science.gov (United States)

    Yunus, Riduan; Noor, Siti Rahimah Mohd; Halid Abdullah, Abd; Nagapan, Sasitharan; Hamid, Abdul Rahim Abdul; Tajudin, Saiful Azhar Ahmad; Rohani Mat Jusof, Siti

    2017-08-01

    Productivity in the manufacturing process of building components can be increased by optimising each advantage that is available in each activity. Identification of critical success factors (CSFs) for lean thinking in the Industrialised Building System (IBS) will be able to minimise cost and reduce time needed to complete a project. The focus of lean thinking in construction is on the production process and the client’s requirement. In developing countries such as Malaysia, the integration of lean thinking in IBS applications is still low and there is a shortage of comprehensive strategies to integrate lean thinking. As key stakeholders, feedback from contractors, manufacturers, developers and the local authority will be able to help the identification of CSFs in integrating lean thinking in IBS applications. The data was collected through a questionnaire survey and analysed quantitatively. There are 31 CSFs for lean thinking in IBS which have been identified in this study. A conceptual model was developed to assist researchers in investigating the influences of CSFs for lean thinking in IBS applications. This study will assist construction players to improvise their manufacturing process in the implementation of IBS to eliminate unnecessary activities and focus instead on significant processes without generating physical and non-physical waste.

  5. A Preliminary Review on Economies of Scale (EOS Towards Industrialized Building System (IBS Manufacturer

    Directory of Open Access Journals (Sweden)

    Tajul Ariffin Syazwana

    2017-01-01

    Full Text Available Industrialized Building System (IBS is a potential technology to improve productivity of construction industry. Controlled production and minimum generation of construction waste are some of the benefits that can be achieved by replacing conventional construction with IBS. In business, IBS is giving a huge opportunity for manufacturer and supplier to expand their business while contributing to construction development. However, bad strategies will put the company in high risk due to higher initial capital for machines and equipment. Therefore, strategic planning for company’s growth, profit maximization, and enhancement of productivity is undeniable to ensure the success of business in construction industry. This preliminary paper is exploring associated factors that affect Economy of Scale (EOS and their relationships in catalyzing the IBS manufacturer especially precast concrete as the scope of study to continue their business in the construction industry. Thus, a framework of EOS is proposed to assist IBS manufacturers to ensure their company’s growth and stability, competitiveness in term of monopoly or an oligopoly, increasing productivity, leading constant returns to scale, and finally increasing the firm’s efficiency. The refined EOS’s conceptual framework is an important turning point to support the development of decision making tools for IBS manufacturer towards their stability and survival in this highly competitive industry.

  6. Medications (for IBS)

    Medline Plus

    Full Text Available ... IBS Patients' Experience and Unmet Needs IBS and Holidays Personal Stories IBS Awareness Month IBS Awareness Month ... IBS Patients' Experience and Unmet Needs IBS and Holidays Personal Stories IBS Awareness Month IBS Awareness Month ...

  7. Medications (for IBS)

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    Full Text Available ... Medications Psychological Treatments Online Studies Living With IBS Relationships and IBS Pregnancy and IBS Travel and IBS ... Medications Psychological Treatments Online Studies Living With IBS Relationships and IBS Pregnancy and IBS Travel and IBS ...

  8. Medications (for IBS)

    Medline Plus

    Full Text Available ... About IBS Gut Bacteria and IBS IBS in Men Other Disorders Testing for IBS Signs and Symptoms ... About IBS Gut Bacteria and IBS IBS in Men Other Disorders Testing for IBS Signs and Symptoms ...

  9. Medications (for IBS)

    Medline Plus

    Full Text Available ... for IBS Signs and Symptoms Overview Recognizing Symptoms Diagnosis of IBS Pain in IBS IBS with Constipation ... for IBS Signs and Symptoms Overview Recognizing Symptoms Diagnosis of IBS Pain in IBS IBS with Constipation ...

  10. Medications (for IBS)

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    Full Text Available ... Travel and IBS IBS Patients' Experience and Unmet Needs IBS and Holidays Personal Stories IBS Awareness Month ... Travel and IBS IBS Patients' Experience and Unmet Needs IBS and Holidays Personal Stories IBS Awareness Month ...

  11. Medications (for IBS)

    Medline Plus

    Full Text Available ... Studies News You Can Use Living With IBS Relationships and IBS Pregnancy and IBS Travel and IBS ... Studies News You Can Use Living With IBS Relationships and IBS Pregnancy and IBS Travel and IBS ...

  12. Medications (for IBS)

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    Full Text Available ... IBS Treatment Working with Your Physician Understanding and Managing Pain in IBS IBS Symptom Treatments Treating IBS ... IBS Treatment Working with Your Physician Understanding and Managing Pain in IBS IBS Symptom Treatments Treating IBS ...

  13. BUSINESS STRATEGY OF LARGE CONTRACTORS IN ADOPTING INDUSTRIALISED BUILDING SYSTEM (IBS: THE MALAYSIAN CASE

    Directory of Open Access Journals (Sweden)

    FRANKY AMBON

    2012-12-01

    Full Text Available Industrialised Building System (IBS is the term coined by the government and industry in Malaysia to represent the construction industry and the application of prefabrication method in building construction. The purpose of this exploratory research paper is to highlight business strategy being pursued by large Malaysian contractors in adopting IBS. The paper uses case study as research method. The analysis is based primarily on cross-case analysis and pattern matching technique. The paper observes contractors which involved in IBS are part of larger holding companies in a corporate set-up include design and manufacturing subsidiaries. The companies positioned themselves as one-stop total solution provider for IBS and offer a wider range of services from design, production, and installation to clients. To become competitive and able to create total solution, contractors need to establish cluster and consortium of integrated project team by creating a partnership when and where it is needed. A vendor development programme modelled along the lines of the development of automotive industry should also be established. Future empirical studies should extensively examine these areas, especially the development of business model for contractors. The availability of this model could help to accelerate the uptake of IBS among contractors.

  14. The Significance of Coordination for Industrialised Building System (IBS Precast Concrete in Construction Industry

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    Fitri Othman Mohd Khairul

    2017-01-01

    Full Text Available IBS precast concrete is construction system which is meant to improve the conventional construction process. However IBS precast concrete projects are suffering from serious problems such as cost overrun, delays and less quality of the end product. The absence of coordination is perceived as the reason for this issue. The purpose of this paper is to review the significance of coordination for IBS precast concrete in the construction industry. It if found that the fragmentation which occurs in the construction industry requires continuity of coordination due to the construction activities are intertwined in nature. Coordination is designated to assist stakeholders in completing and complementing each other with the paramount focus of achieving the objective. Proper coordination is required in delivering the desired construction product at the ideal time, cost and quality. As for the findings, the significance of coordination for IBS precast concrete can be seen through the precast concrete construction phases which consist of planning; design; manufacturing; transportation and installation/construction. These phases are meant to complement construction process with the purpose to reduce issues of fragmentation and enhance IBS precast concrete project delivery.

  15. A new method using insert-based systems (IBS) to improve cell behavior study on flexible and rigid biomaterials

    OpenAIRE

    Grenade, Charlotte; Moniotte, Nicolas; Rompen, Eric; Vanheusden, Alain; Mainjot, Amélie; De Pauw-Gillet, Marie-Claire

    2016-01-01

    In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of both faces of permeable materials. The objective of the present study was to develop a reliable in vitro method to study cell behavior on rigid and flexible/permeable biomaterials elaborating two specific insert-based systems (IBS-R and IBS-F respectively). IBS-R was designed as a specific cylin...

  16. TINGKAT KEPUASAN PENGGUNA APLIKASI INTERSYSTEM BUSINESS SOLUTION (IBS PADA PT CITAJAYA INFINITE SYSTEM

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    Anderes Gui

    2009-05-01

    Full Text Available Use of applications to assist business processes to be completed faster, saat have been very widely adopted by companies so that good performance yang applications and meet the needs of users will be very important. The purpose of this research is to find the application user expectations Intersystem Business Solution (IBS in PT Citajaya Infinite System and find out how the performance of these applications after implemented so that will be generated an output, which form the level of satisfaction from the use of applications by managers and employees at the company. Data collection methods used were observation, interviews, and questionnaires. Manual methods used in data processing, Microsoft Excel 2003, and SPSS version 13.0. While the analysis method using gap analysis to determine the scale and range of satisfaction levels. So, one conclusion that can be drawn from this study is the performance of this application is sufficient to meet user expectations.Keywords: level of satisfaction, users, IBS applicationABSTRAKPenggunaan aplikasi untuk membantu proses bisnis agar menjadi lebih cepat diselesaikan, saat ini sudah sangat banyak diterapkan oleh perusahaan-perusahaan sehingga kinerja aplikasi yang baik dan memenuhi kebutuhan dari pengguna akan sangat penting sekali. Tujuan dari penelitian ini adalah untuk mencari harapan pengguna aplikasi Intersystem Business Solution (IBS pada PT Citajaya Infinite System dan mengetahui bagaimana kinerja aplikasi ini setelah diimplementasikan sehingga akan dihasilkan sebuah output, yang berupa tingkat kepuasan dari penggunaan aplikasi oleh para manajer dan karyawan di perusahaan tersebut. Metode pengumpulan data yang digunakan adalah observasi, wawancara, dan kuesioner. Metode pengolahan datanya menggunakan manual, Microsoft Excel 2003, dan SPSS versi 13.0. Sedangkan metode analisisnya menggunakan gap analysis dan rentang skala untuk menentukan tingkat kepuasan. Jadi, salah satu simpulan yang dapat diambil

  17. IBS Diet

    Science.gov (United States)

    ... the most common questions IBS patients have is what food to avoid. This can drive a person to ... Global Treatments IBS Diet What to Do and What to Avoid Foods That Cause Cramping and Diarrhea Foods that Cause ...

  18. Medications (for IBS)

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    Full Text Available ... and Symptoms Overview Recognizing Symptoms Diagnosis of IBS Pain in IBS IBS with Constipation Constipated Diarrhea IBS ... Treatment Working with Your Physician Understanding and Managing Pain in IBS IBS Symptom Treatments Treating IBS Pain ...

  19. Introduction to IBS

    Science.gov (United States)

    ... Day Art of IBS Gallery Contact Us Search Introduction to IBS Details What is IBS? Last Updated: ... tax-deductible donation. Make Donation What is IBS? Introduction to IBS Symptoms of IBS What Causes IBS? ...

  20. Medications (for IBS)

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    Full Text Available ... With IBS Relationships and IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience and Unmet Needs IBS and ... Agents Antidiarrheal Agents Antidepressant Medications Newer IBS Medications Probiotics ...

  1. Medications (for IBS)

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  2. Towards Integrated Team Practice: A Case of Malaysian Industrialised Building System (IBS Construction Projects

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    Mohd Nawi Mohd Nasrun

    2014-01-01

    Full Text Available Problems associated with fragmentation in the traditional construction process, such as isolation of professionals, lack of co-ordination between design and construction, and the sequential manner of its processes, has impacted on construction performance leading to a lack of integration, wastage, low productivity and efficiency. Integrated team practice is perceived as paramount. Unfortunately, there has a limitation of study focus on the dimension of fully integrated team especially for Malaysian Industrialised Building System (IBS projects. Accordingly, this research paper explores and identifies the dimension of fully integrated team from the traditional approach and conduct a validation process for implementing it in Malaysian IBS projects. The research presented uses interviews case study to obtain qualitative data. It was found that the dimension of fully integrated team from the traditional construction process could apply to the Malaysian IBS projects. Suggestions on how an integrated team practice in IBS design and construction process in order to minimise the fragmentation gaps will be concluded.

  3. The sweet potato IbMYB1 gene as a potential visible marker for sweet potato intragenic vector system.

    Science.gov (United States)

    Kim, Cha Young; Ahn, Young Ock; Kim, Sun Ha; Kim, Yun-Hee; Lee, Haeng-Soon; Catanach, Andrew S; Jacobs, Jeanne M E; Conner, Anthony J; Kwak, Sang-Soo

    2010-07-01

    MYB transcription factors play important roles in transcriptional regulation of many secondary metabolites including anthocyanins. We cloned the R2R3-MYB type IbMYB1 complementary DNAs from the purple-fleshed sweet potato (Ipomoea batatas L. cv Sinzami) and investigated the expression patterns of IbMYB1 gene with IbMYB1a and IbMYB1b splice variants in leaf and root tissues of various sweet potato cultivars by reverse transcription-polymerase chain reaction. The transcripts of IbMYB1 were predominantly expressed in the purple-fleshed storage roots and they were also detectable in the leaf tissues accumulating anthocyanin pigments. In addition, transcript levels of IbMYB1 gene were up-regulated by treatment with methyl jasmonate or salicylic acid in leaf and root tissues of cv. White Star. To set up the intragenic vector system in sweet potato, we first evaluated the utilization of the IbMYB1 gene as a visible selectable marker. The IbMYB1a was transiently expressed in tobacco leaves under the control of a constitutive cauliflower mosaic virus 35S promoter, a root-specific and sucrose-inducible sporamin promoter, and an oxidative stress-inducible sweet potato anionic peroxidase2 promoter. We also showed that overexpression of IbMYB1a induced massive anthocyanin pigmentation in tobacco leaves and up-regulated the transcript levels of the structural genes in anthocyanin biosynthetic pathway. Furthermore, high-performance liquid chromatography analysis revealed that the expression of IbMYB1a led to production of cyanidin as a major core molecule of anthocyanidins in tobacco leaves. These results suggest that the IbMYB1 gene can be applicable to a visible marker for sweet potato transformation with intragenic vectors, as well as the production of anthocyanin as important nutritive value in other plant species.

  4. FIST/6IB1, BWR/6 System Responses to Intermediate Break in Recirculation Suction Line LINE

    International Nuclear Information System (INIS)

    1993-01-01

    1 - Description of test facility: BWR/6-218 standard plant. A full size bundle with electrically heated rods is used to simulate the reactor core. A scaling ratio of 1/624 is applied in the design of the system components. Key features of the FIST facility include: (1) Full height test vessel and internals; (2) correctly scaled fluid volume distribution; (3) simulation of ECCS, S/RV, and ADS; (4) level trip capability; (5) heated feedwater supply system, which provides the capability for steady state operation. 2 - Description of test: Test 6IB1 investigates system responses to an intermediate break in the recirculation suction line. BWR system licensing evaluations for various size recirculation break LOCA's indicates that a break size of about 0.2 sq.ft., without LPCS operation, is the highest PCT case for the intermediate break LOCA. Test 6IB1 simulates this event

  5. Medications (for IBS)

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  6. Medications (for IBS)

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    Full Text Available ... Studies News You Can Use Living With IBS Relationships and IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience and Unmet Needs ... Studies News You Can Use Living With IBS Relationships and IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience and Unmet Needs ...

  7. A new method using insert-based systems (IBS) to improve cell behavior study on flexible and rigid biomaterials.

    Science.gov (United States)

    Grenade, Charlotte; Moniotte, Nicolas; Rompen, Eric; Vanheusden, Alain; Mainjot, Amélie; De Pauw-Gillet, Marie-Claire

    2016-12-01

    In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of both faces of permeable materials. The objective of the present study was to develop a reliable in vitro method to study cell behavior on rigid and flexible/permeable biomaterials elaborating two specific insert-based systems (IBS-R and IBS-F respectively). IBS-R was designed as a specific cylindrical polytetrafluoroethylene (PTFE) system to evaluate attachment, proliferation and morphology of human gingival fibroblasts (HGFs) on grade V titanium and lithium disilicate glass-ceramic discs characteristics of dental prostheses. The number of cells, their covering on discs and their morphology were determined from MTS assays and microscopic fluorescent images after 24, 48 and 72 h. IBS-F was developed as a two components system to study HGFs behavior on guided bone regeneration polyester membranes. The viability and the membrane barrier effect were evaluated by metabolic MTS assays and by scanning electron microscopy. IBS-R and IBS-F were shown to promote (1) easy and rapid handling; (2) cell retention on biomaterial surface; (3) accurate evaluation of the cellular proliferation, spreading and viability; (4) use of non-toxic material. Moreover IBS-F allowed the study of the cell migration through degradable membranes, with an access to both faces of the biomaterial and to the bottom of culture wells for medium changing.

  8. Medications (for IBS)

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    Full Text Available ... Treating IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complementary or Alternative Treatments Medications Psychological ... Treating IBS Pain IBS Global Treatments IBS Diet Low FODMAP Diet Complementary or Alternative Treatments Medications Psychological ...

  9. Motivational Factors on Adopting Modular Coordination Concept in Industrialized Building System (IBS

    Directory of Open Access Journals (Sweden)

    Yunus Riduan

    2016-01-01

    Full Text Available Modular coordination (MC is recognized as a tool towards rationalization and industrialization. The implementation of MC concept in the design stage may improve the constructability and construction time. However, the implementation of MC in Industrialized Building System (IBS implementation is still low compare to other developed countries such as the United Kingdom, Sweden and Japan. This paper examined the interrelationship between motivational factors of stakeholders in adopting MC concept using Interpretative Structural Modeling (ISM. Questionnaire survey was engaged in this study to identify significant motivational factors. Then, semi-structure interviews were used to collect qualitative data. ISM was adopted to build relationship between factors and develop an initial model to promote the adoption of MC in IBS construction. Seven (7 significant motivational factors were identified in this research namely 1 ‘stakeholder’s commitment’, 2 ‘reduce site disruption’, 3 ‘increase productivity’, 4 ‘high skilled workers’, 5 ‘site sustainability (environment, economy and social benefits’ 6 ‘standardization’ and 7 ‘enabling ‘open building’ concept’. The result using Matrice d’Impacts Croises Multiplication Applique an Clasment (MICMAC shows that there are three factors can be categorized as Independent / Driving Factors namely ‘stakeholder’s commitment’, ‘standardization’ and ‘enabling “open building” concept’. These factors should be explored in details to enhance the adoption of IBS in Malaysia. The findings provide a very good platform for a further research in formulating an efficient solution to promote MC concept adoption among the stakeholders. This scenario will improve the deliverables of IBS construction and eliminate negative perception in its implementation.

  10. A review on the current issues and barriers of Industrialised Building System (IBS) adoption in Malaysia’s construction industry

    Science.gov (United States)

    Amin, M. A. Mohd; Abas, N. H.; Shahidan, S.; Rahmat, M. H.; Suhaini, N. A.; Nagapan, S.; Rahim, R. Abdul

    2017-11-01

    Malaysia considers the construction industry as one of the main contributors to its Gross Domestic Product (GDP). However, there are some unresolved issues arising from the ongoing and widespread adoption of the conventional method of construction such as the resultant fragmentation of the industry itself; delays in production and delivery time of unnecessary wastages and lack of sustainability practice. Malaysian Government has been continuously encouraging the industry to use, partly or if not wholly, the Industrialized Building System (IBS), which is considered to be an important part of sustainable construction initiative. IBS was introduced to Malaysia as the solution to issues related to dependencies of foreign workers, raising demand for affordable accommodations and improving image, quality and productivity of construction industry. However, the IBS adoption in Malaysia remains low. This paper presents the review of the current issues and barriers of IBS adoption in Malaysian construction industry.

  11. Medications (for IBS)

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    Full Text Available ... Month IBS Awareness Month Tips of the Day Art of IBS Gallery Contact Us About IBS Twitter ... Month IBS Awareness Month Tips of the Day Art of IBS Gallery Contact Us Search Medications Details ...

  12. Medications (for IBS)

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    Full Text Available ... Irritable Bowel Syndrome Symptom Diary Testing in IBS Changes You Should Not Ignore if You Have IBS Treatment Working with Your Physician Understanding and Managing Pain in IBS IBS Symptom Treatments Treating IBS ...

  13. Medications (for IBS)

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    Full Text Available ... Complementary or Alternative Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS Relationships and IBS Pregnancy and IBS Travel and IBS IBS Patients' Experience and Unmet Needs ...

  14. Fission Meter Information Barrier Attribute Measurement System: Task 1 Report: Document existing Fission Meter neutron IB system

    Energy Technology Data Exchange (ETDEWEB)

    Kerr, P. L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-02-28

    An SNM attribute Information Barrier (IB) system was developed for a 2011 US/UK Exercise. The system was modified and extensively tested in a 2013-2014 US-UK Measurement Campaign. This work demonstrated rapid deployment of an IB system for potential treaty use. The system utilizes an Ortec Fission Meter neutron multiplicity counter and custom computer code. The system demonstrates a proof-of-principle automated Pu-240 mass determination with an information barrier. After a software start command is issued, the system automatically acquires and downloads data, performs an analysis, and displays the results. This system conveys the results of a Pu mass threshold measurements in a way the does not reveal sensitive information. In full IB mode, only red/green ‘lights’ are displayed in the software. In test mode, more detailed information is displayed. The code can also read in, analyze, and display results from previously acquired or simulated data. Because the equipment is commercial-off-the-shelf (COTS), the system demonstrates a low-cost short-lead-time technology for treaty SNM attribute measurements. A deployed system will likely require integration of additional authentication and tamper-indicating technologies. This will be discussed for the project in this and future progress reports.

  15. Model-based version management system framework

    International Nuclear Information System (INIS)

    Mehmood, W.

    2016-01-01

    In this paper we present a model-based version management system. Version Management System (VMS) a branch of software configuration management (SCM) aims to provide a controlling mechanism for evolution of software artifacts created during software development process. Controlling the evolution requires many activities to perform, such as, construction and creation of versions, identification of differences between versions, conflict detection and merging. Traditional VMS systems are file-based and consider software systems as a set of text files. File based VMS systems are not adequate for performing software configuration management activities such as, version control on software artifacts produced in earlier phases of the software life cycle. New challenges of model differencing, merge, and evolution control arise while using models as central artifact. The goal of this work is to present a generic framework model-based VMS which can be used to overcome the problem of tradition file-based VMS systems and provide model versioning services. (author)

  16. Medications (for IBS)

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    Full Text Available Donate Find a Doctor Join eNewsletter Sidebar × MOBILE MENU About Us What is IBS? What is IBS? Facts About IBS Gut Bacteria and IBS IBS in Men ... Art of IBS Gallery Contact Us About IBS Twitter Facebook YouTube Search Search ... About Us What is ...

  17. Integrated Procurement Management System, Version II

    Science.gov (United States)

    Collier, L. J.

    1985-01-01

    Integrated Procurement Management System, Version II (IPMS II) is online/ batch system for collecting developing, managing and disseminating procurementrelated data at NASA Johnson Space Center. Portions of IPMS II adaptable to other procurement situations.

  18. Medications (for IBS)

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  19. Medications (for IBS)

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    Full Text Available ... Gallery Contact Us About IBS Twitter Facebook YouTube Search Search ... About Us What is IBS? What is IBS? ... the Day Art of IBS Gallery Contact Us Search Medications Details Medications Last Updated: 01 July 2017 ...

  20. Medications (for IBS)

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    Full Text Available ... and Holidays Personal Stories IBS Awareness Month IBS Awareness Month Tips of the Day ... IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in irritable bowel syndrome (IBS) ...

  1. Medications (for IBS)

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    Full Text Available ... Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS Relationships and IBS Pregnancy ... Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS Relationships and IBS Pregnancy ...

  2. Medications (for IBS)

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  3. MULTI-PERSON DECISION FOR SUSTAINABLE DESIGN ON IBS FLOOR SYSTEM SELECTION

    Directory of Open Access Journals (Sweden)

    Christiono Utomo

    2013-05-01

    Full Text Available Selecting a design solution (choice problem is one of the natures of design decision. If the problem is more complex and involves multi participants, decision aid is necessary. This paper discusses the nature of group judgment and negotiation on multi-criteria decision-making methodologies. It presents a conceptual model of negotiation support in a multi-person decision on building floor system selection. Decision technique (AHP was applied for decision process in a satisfying options and game theory for coalition formation. An n-person cooperative game is represented by a set of all players. The proposed coalition formation model enables each agent to select individually or coalition. It improves the value of building system decision. It further emphasizes the importance of performance evaluation in the design process and value-based decision. The support model can be extended to an automated negotiation and in different building system selection with proper  modification. Keywords: Multi-person, design decision, IBS, floor system selection.

  4. Medications (for IBS)

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  5. Medications (for IBS)

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  6. Medications (for IBS)

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  7. Medications (for IBS)

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  8. Medications (for IBS)

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  9. Medications (for IBS)

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    Full Text Available ... Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in irritable bowel syndrome (IBS) ... include bran or psyllium. Anticholinergics/Antispasmodics – have limited benefit for treating IBS. In some persons they relieve ...

  10. The communication in industrialised building system (IBS) construction project: Virtual environment

    Science.gov (United States)

    Pozin, Mohd Affendi Ahmad; Nawi, Mohd Nasrun Mohd

    2017-10-01

    Large portion of numbers team organization in the IBS construction sector is known are being fragmented. That is contributed from a segregation of construction activity thus create team working in virtually. Virtual team are the nature when teams are working in distributed area, across culture and time. Therefore, teams can be respond to the task without relocating to the site project and settle down a problem through information and communication technology (ICT). The emergence of virtual team are carry out by advancements in communication technologies as a medium to improve project team communication in project delivery process on IBS construction. Based on literature review from previous study and data collected from interviewing, this paper aim to identified communication challenges among project team members according to current project development practices in IBS construction project. Hence, in attempt to develop effective communication through the advantages of virtual team approach for IBS construction project. In order to ensure the data is gathered comprehensively and accurately, the data was collected from project managers by using semi structured interview method. It was found that virtual team approach could be enable competitive challenges on complexity in the construction project management process.

  11. Knowledge-Based Energy Damage Model for Evaluating Industrialised Building Systems (IBS Occupational Health and Safety (OHS Risk

    Directory of Open Access Journals (Sweden)

    Abas Nor Haslinda

    2016-01-01

    Full Text Available Malaysia’s construction industry has been long considered hazardous, owing to its poor health and safety record. It is proposed that one of the ways to improve safety and health in the construction industry is through the implementation of ‘off-site’ systems, commonly termed ‘industrialised building systems (IBS’ in Malaysia. This is deemed safer based on the risk concept of reduced exposure, brought about by the reduction in onsite workers; however, no method yet exists for determining the relative safety of various construction methods, including IBS. This study presents a comparative evaluation of the occupational health and safety (OHS risk presented by different construction approaches, namely IBS and traditional methods. The evaluation involved developing a model based on the concept of ‘argumentation theory’, which helps construction designers integrate the management of OHS risk into the design process. In addition, an ‘energy damage model’ was used as an underpinning framework. Development of the model was achieved through three phases, namely Phase I – knowledge acquisitaion, Phase II – argument trees mapping, and Phase III – validation of the model. The research revealed that different approaches/methods of construction projects carried a different level of energy damage, depending on how the activities were carried out. A study of the way in which the risks change from one construction process to another shows that there is a difference in the profile of OHS risk between IBS construction and traditional methods.Therefore, whether the option is an IBS or traditional approach, the fundamental idea of the model is to motivate construction designers or decision-makers to address safety in the design process and encourage them to examine carefully the probable OHS risk variables surrounding an action, thus preventing accidents in construction.

  12. Medications (for IBS)

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    Full Text Available ... Antidepressant Medications Newer IBS Medications Probiotics and Antibiotics Psychological Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation Techniques for IBS Take Part in Online ...

  13. Medications (for IBS)

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  14. Mission Data System Java Edition Version 7

    Science.gov (United States)

    Reinholtz, William K.; Wagner, David A.

    2013-01-01

    The Mission Data System framework defines closed-loop control system abstractions from State Analysis including interfaces for state variables, goals, estimators, and controllers that can be adapted to implement a goal-oriented control system. The framework further provides an execution environment that includes a goal scheduler, execution engine, and fault monitor that support the expression of goal network activity plans. Using these frameworks, adapters can build a goal-oriented control system where activity coordination is verified before execution begins (plan time), and continually during execution. Plan failures including violations of safety constraints expressed in the plan can be handled through automatic re-planning. This version optimizes a number of key interfaces and features to minimize dependencies, performance overhead, and improve reliability. Fault diagnosis and real-time projection capabilities are incorporated. This version enhances earlier versions primarily through optimizations and quality improvements that raise the technology readiness level. Goals explicitly constrain system states over explicit time intervals to eliminate ambiguity about intent, as compared to command-oriented control that only implies persistent intent until another command is sent. A goal network scheduling and verification process ensures that all goals in the plan are achievable before starting execution. Goal failures at runtime can be detected (including predicted failures) and handled by adapted response logic. Responses can include plan repairs (try an alternate tactic to achieve the same goal), goal shedding, ignoring the fault, cancelling the plan, or safing the system.

  15. Cervical Cancer Stage IB

    Science.gov (United States)

    ... hyphen, e.g. -historical Searches are case-insensitive Cervical Cancer Stage IB Add to My Pictures View /Download : ... 1613x1200 View Download Large: 3225x2400 View Download Title: Cervical Cancer Stage IB Description: Stage IB1 and IB2 cervical ...

  16. Medications (for IBS)

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    Full Text Available ... by a physician who specializes in motility or stress-related gastrointestinal disorders. More complex medication regimens, and ... IBS Medications Probiotics and Antibiotics Psychological Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation Techniques for IBS Take ...

  17. Medications (for IBS)

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    Full Text Available ... IBS Medications Probiotics and Antibiotics Psychological Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation Techniques for IBS Take Part in Online Studies Working With Your Doctor Successful relationships with healthcare providers are an important part of ...

  18. Medications (for IBS)

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    Full Text Available ... Diet Complementary or Alternative Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS ... Diet Complementary or Alternative Treatments Medications Psychological Treatments Online Studies News You Can Use Living With IBS ...

  19. Medications (for IBS)

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    Full Text Available ... Agents Antidepressant Medications Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in ... Agents Antidepressant Medications Newer IBS Medications Probiotics and ... Treatments Understanding Stress Cognitive Behavioral Therapy Relaxation ...

  20. Medications (for IBS)

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    Full Text Available ... have limited benefit for treating IBS. In some persons they relieve abdominal pain or discomfort, usually if ... Anti-anxiety medications – can be helpful for some people with IBS, mainly those with emotional distress. There ...

  1. Medications (for IBS)

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  2. Medications (for IBS)

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  3. Medications (for IBS)

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  4. Medications (for IBS)

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  5. Medications (for IBS)

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  8. Medications (for IBS)

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  9. A framework of initiatives for successful application of life cycle costing (LCC in industrialised building system (IBS in Malaysian construction industry

    Directory of Open Access Journals (Sweden)

    Shamsuddin Siti Mazzuana

    2017-01-01

    Full Text Available Industrialised Building System (IBS contributes a great shift in sustainable construction and benefits the society. Previous studies have proven in general that one of the hindrances in promoting sustainable in IBS, is a high cost for any pre-cast material specifically thus effected the overall cost. The introduction of Life Cycle Costing (LCC leads into providing a better and comprehensive cost estimation, including projecting actual cost to operate the building, hence providing a better baseline for decision making. The lacking application of LCC in IBS is still in trivial impact, therefore, this paper presents a framework which produced by expressing the successful initiatives of LCC and IBS in Malaysia construction industry. The framework developed based on findings from the extensive literature reviews, 164 responded questionnaires, and 19 expert opinions, which has three sections: Strategy Development, System Development and the last part is Decision Level. Aspects of objectivity, practicality, reliability, completeness that were likely to be implemented in the Malaysian construction industry were used. There are significant opinions on the usefulness and completeness of the proposed framework in providing a comprehensive cost estimates which helps much in deciding to carry out IBS or remain with a traditional construction method.

  10. Medications (for IBS)

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  11. Medications (for IBS)

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    Full Text Available ... Tips on Finding a Doctor Doctor Visit Worksheet Words to Know Changing Doctors IBS Symptom Treatments IBS ... arises requiring an expert’s care. © Copyright 1998-2018 International Foundation for Functional Gastrointestinal Disorders, Inc. (IFFGD). All ...

  12. IBS Treatment Options

    Science.gov (United States)

    ... 01 July 2017 Print A short bout of abdominal pain and diarrhea or constipation now and then is not unusual. But long-term or recurring symptoms are not normal. They may signal irritable bowel syndrome (IBS) – and are generally treatable. IBS Treatments Depend ...

  13. Medications (for IBS)

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  14. Medications (for IBS)

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  15. Gene Repression in Haloarchaea Using the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas I-B System.

    Science.gov (United States)

    Stachler, Aris-Edda; Marchfelder, Anita

    2016-07-15

    The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system is used by bacteria and archaea to fend off foreign genetic elements. Since its discovery it has been developed into numerous applications like genome editing and regulation of transcription in eukaryotes and bacteria. For archaea currently no tools for transcriptional repression exist. Because molecular biology analyses in archaea become more and more widespread such a tool is vital for investigating the biological function of essential genes in archaea. Here we use the model archaeon Haloferax volcanii to demonstrate that its endogenous CRISPR-Cas system I-B can be harnessed to repress gene expression in archaea. Deletion of cas3 and cas6b genes results in efficient repression of transcription. crRNAs targeting the promoter region reduced transcript levels down to 8%. crRNAs targeting the reading frame have only slight impact on transcription. crRNAs that target the coding strand repress expression only down to 88%, whereas crRNAs targeting the template strand repress expression down to 8%. Repression of an essential gene results in reduction of transcription levels down to 22%. Targeting efficiencies can be enhanced by expressing a catalytically inactive Cas3 mutant. Genes can be targeted on plasmids or on the chromosome, they can be monocistronic or part of a polycistronic operon. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  16. Gene Repression in Haloarchaea Using the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas I-B System*

    Science.gov (United States)

    Stachler, Aris-Edda; Marchfelder, Anita

    2016-01-01

    The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system is used by bacteria and archaea to fend off foreign genetic elements. Since its discovery it has been developed into numerous applications like genome editing and regulation of transcription in eukaryotes and bacteria. For archaea currently no tools for transcriptional repression exist. Because molecular biology analyses in archaea become more and more widespread such a tool is vital for investigating the biological function of essential genes in archaea. Here we use the model archaeon Haloferax volcanii to demonstrate that its endogenous CRISPR-Cas system I-B can be harnessed to repress gene expression in archaea. Deletion of cas3 and cas6b genes results in efficient repression of transcription. crRNAs targeting the promoter region reduced transcript levels down to 8%. crRNAs targeting the reading frame have only slight impact on transcription. crRNAs that target the coding strand repress expression only down to 88%, whereas crRNAs targeting the template strand repress expression down to 8%. Repression of an essential gene results in reduction of transcription levels down to 22%. Targeting efficiencies can be enhanced by expressing a catalytically inactive Cas3 mutant. Genes can be targeted on plasmids or on the chromosome, they can be monocistronic or part of a polycistronic operon. PMID:27226589

  17. MATLAB Software Versions and Licenses for the Peregrine System |

    Science.gov (United States)

    High-Performance Computing | NREL MATLAB Software Versions and Licenses for the Peregrine System MATLAB Software Versions and Licenses for the Peregrine System Learn about the MATLAB software Peregrine is R2017b. Licenses MATLAB is proprietary software. As such, users have access to a limited number

  18. Medications (for IBS)

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  19. Medications (for IBS)

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  2. Medications (for IBS)

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  3. Medications (for IBS)

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  4. Medications (for IBS)

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  5. Medications (for IBS)

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    Full Text Available ... He or she can help you monitor quality, effectiveness, possible interactions with other medicines you may be ... Read more about newer IBS medications. Summary The effectiveness of various agents differs between individuals. A medication ...

  7. Medications (for IBS)

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    Full Text Available ... Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in irritable bowel syndrome ( ... take for a therapeutic effect counts as a medicine. It can be readily available over-the-counter, ...

  8. Medications (for IBS)

    Medline Plus

    Full Text Available ... Help You? IFFGD is a nonprofit education and research organization. Our mission is to inform, assist, and ... About IFFGD Our Mission Awareness Activities Advocacy Activities Research Leadership Industry Council Contact us IBS Treatment Working ...

  9. Medications (for IBS)

    Medline Plus

    Full Text Available ... Newer IBS Medications Probiotics and Antibiotics Pharmacologic, or drug, therapy is best used in irritable bowel syndrome ( ... limited by prescription only. It might be a drug or a supplement; manufactured or "natural." It might ...

  10. Medications (for IBS)

    Medline Plus

    Full Text Available ... be taken on a more long-term basis. These include low dose antidepressant agents or the relatively ... IBS in multi-center, high quality clinical trials. These are prescription medications intended for specific use under ...

  11. Medications (for IBS)

    Medline Plus

    Full Text Available ... Beth Israel Deaconess Medical Center, Boston, MA. Last modified on February 23, 2015 at 12:18:55 ... Dietary Fiber 12 Week Elimination Diet for IBS Rice-Based Foods Low-FODMAP Diet What Are FODMAPs? ...

  12. Medications (for IBS)

    Medline Plus

    Full Text Available ... have limited benefit for treating IBS. In some persons they relieve abdominal pain or discomfort, usually if ... Summary The effectiveness of various agents differs between individuals. A medication regimen must be carefully chosen by ...

  13. Medications (for IBS)

    Medline Plus

    Full Text Available ... for some people with IBS, mainly those with emotional distress. There are also effective medications available that ... not linked to depression, but rather likely to effects on the brain and the gut. Antidepressant medications ...

  14. Medications (for IBS)

    Medline Plus

    Full Text Available ... Read more about antidiarrheal agents. Anti-anxiety medications – can be helpful for some people with IBS, mainly those with emotional distress. There are also effective medications available that relieve ...

  15. Medications (for IBS)

    Medline Plus

    Full Text Available ... You? IFFGD is a nonprofit education and research organization. Our mission is to inform, assist, and support ... IFFGD Our Mission Awareness Activities Advocacy Activities Research Leadership Industry Council Contact us IBS Treatment Working With ...

  16. Medications (for IBS)

    Medline Plus

    Full Text Available ... MA. Last modified on February 23, 2015 at 12:18:55 PM Treatment Understanding and Managing Pain ... Foods that Cause Gas and Bloating Dietary Fiber 12 Week Elimination Diet for IBS Rice-Based Foods ...

  17. Medications (for IBS)

    Medline Plus

    Full Text Available ... discomfort, usually if the symptoms occur soon after eating. Examples include dicyclomine (Bentyl), and hyoscyamine (Levsin). Read ... treatment of IBS symptoms is not linked to depression, but rather likely to effects on the brain ...

  18. Medications (for IBS)

    Medline Plus

    Full Text Available ... depression, but rather likely to effects on the brain and the gut. Antidepressant medications can reduce the intensity of pain signals going from gut to brain. Read more about antidepressant medications. Newer IBS-Targeted ...

  19. Medications (for IBS)

    Medline Plus

    Full Text Available ... it. He or she can help you monitor quality, effectiveness, possible interactions with other medicines you may ... effective in treating IBS in multi-center, high quality clinical trials. These are prescription medications intended for ...

  20. Medications (for IBS)

    Medline Plus

    Full Text Available ... of constipation. Laxatives should be used under the supervision of a physician. Read more about laxatives. Bulking ... medications intended for specific use under a doctor’s supervision. Read more about newer IBS medications. Summary The ...

  1. Medications (for IBS)

    Medline Plus

    Full Text Available ... IBS Medications Probiotics and Antibiotics Psychological ... With Your Doctor Successful relationships with healthcare providers are an important part of managing life with a long-term digestive disorder. Working with ...

  2. CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (IBM PC VERSION)

    Science.gov (United States)

    Donnell, B.

    1994-01-01

    command line version. For the UNIX version of CLIPS 6.0, the command line interface has been successfully implemented on a Sun4 running SunOS, a DECstation running DEC RISC ULTRIX, an SGI Indigo Elan running IRIX, a DEC Alpha AXP running OSF/1, and an IBM RS/6000 running AIX. Command line interface executables are included for Sun4 computers running SunOS 4.1.1 or later and for the DEC RISC ULTRIX platform. The makefiles may have to be modified slightly to be used on other UNIX platforms. The UNIX, Macintosh, and IBM PC versions of CLIPS 6.0 each have a platform specific interface. Source code, a makefile, and an executable for the Windows 3.1 interface version of CLIPS 6.0 are provided only on the IBM PC distribution diskettes. Source code, a makefile, and an executable for the Macintosh interface version of CLIPS 6.0 are provided only on the Macintosh distribution diskettes. Likewise, for the UNIX version of CLIPS 6.0, only source code and a makefile for an X-Windows interface are provided. The X-Windows interface requires MIT's X Window System, Version 11, Release 4 (X11R4), the Athena Widget Set, and the Xmu library. The source code for the Athena Widget Set is provided on the distribution medium. The X-Windows interface has been successfully implemented on a Sun4 running SunOS 4.1.2 with the MIT distribution of X11R4 (not OpenWindows), an SGI Indigo Elan running IRIX 4.0.5, and a DEC Alpha AXP running OSF/1 1.2. The VAX version of CLIPS 6.0 comes only with the generic command line interface. ASCII makefiles for the command line version of CLIPS are provided on all the distribution media for UNIX, VMS, and DOS. Four executables are provided with the IBM PC version: a windowed interface executable for Windows 3.1 built using Borland C++ v3.1, an editor for use with the windowed interface, a command line version of CLIPS for Windows 3.1, and a 386 command line executable for DOS built using Zortech C++ v3.1. All four executables are capable of utilizing extended memory

  3. CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (UNIX VERSION)

    Science.gov (United States)

    Donnell, B.

    1994-01-01

    command line version. For the UNIX version of CLIPS 6.0, the command line interface has been successfully implemented on a Sun4 running SunOS, a DECstation running DEC RISC ULTRIX, an SGI Indigo Elan running IRIX, a DEC Alpha AXP running OSF/1, and an IBM RS/6000 running AIX. Command line interface executables are included for Sun4 computers running SunOS 4.1.1 or later and for the DEC RISC ULTRIX platform. The makefiles may have to be modified slightly to be used on other UNIX platforms. The UNIX, Macintosh, and IBM PC versions of CLIPS 6.0 each have a platform specific interface. Source code, a makefile, and an executable for the Windows 3.1 interface version of CLIPS 6.0 are provided only on the IBM PC distribution diskettes. Source code, a makefile, and an executable for the Macintosh interface version of CLIPS 6.0 are provided only on the Macintosh distribution diskettes. Likewise, for the UNIX version of CLIPS 6.0, only source code and a makefile for an X-Windows interface are provided. The X-Windows interface requires MIT's X Window System, Version 11, Release 4 (X11R4), the Athena Widget Set, and the Xmu library. The source code for the Athena Widget Set is provided on the distribution medium. The X-Windows interface has been successfully implemented on a Sun4 running SunOS 4.1.2 with the MIT distribution of X11R4 (not OpenWindows), an SGI Indigo Elan running IRIX 4.0.5, and a DEC Alpha AXP running OSF/1 1.2. The VAX version of CLIPS 6.0 comes only with the generic command line interface. ASCII makefiles for the command line version of CLIPS are provided on all the distribution media for UNIX, VMS, and DOS. Four executables are provided with the IBM PC version: a windowed interface executable for Windows 3.1 built using Borland C++ v3.1, an editor for use with the windowed interface, a command line version of CLIPS for Windows 3.1, and a 386 command line executable for DOS built using Zortech C++ v3.1. All four executables are capable of utilizing extended memory

  4. CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (MACINTOSH VERSION)

    Science.gov (United States)

    Riley, G.

    1994-01-01

    command line version. For the UNIX version of CLIPS 6.0, the command line interface has been successfully implemented on a Sun4 running SunOS, a DECstation running DEC RISC ULTRIX, an SGI Indigo Elan running IRIX, a DEC Alpha AXP running OSF/1, and an IBM RS/6000 running AIX. Command line interface executables are included for Sun4 computers running SunOS 4.1.1 or later and for the DEC RISC ULTRIX platform. The makefiles may have to be modified slightly to be used on other UNIX platforms. The UNIX, Macintosh, and IBM PC versions of CLIPS 6.0 each have a platform specific interface. Source code, a makefile, and an executable for the Windows 3.1 interface version of CLIPS 6.0 are provided only on the IBM PC distribution diskettes. Source code, a makefile, and an executable for the Macintosh interface version of CLIPS 6.0 are provided only on the Macintosh distribution diskettes. Likewise, for the UNIX version of CLIPS 6.0, only source code and a makefile for an X-Windows interface are provided. The X-Windows interface requires MIT's X Window System, Version 11, Release 4 (X11R4), the Athena Widget Set, and the Xmu library. The source code for the Athena Widget Set is provided on the distribution medium. The X-Windows interface has been successfully implemented on a Sun4 running SunOS 4.1.2 with the MIT distribution of X11R4 (not OpenWindows), an SGI Indigo Elan running IRIX 4.0.5, and a DEC Alpha AXP running OSF/1 1.2. The VAX version of CLIPS 6.0 comes only with the generic command line interface. ASCII makefiles for the command line version of CLIPS are provided on all the distribution media for UNIX, VMS, and DOS. Four executables are provided with the IBM PC version: a windowed interface executable for Windows 3.1 built using Borland C++ v3.1, an editor for use with the windowed interface, a command line version of CLIPS for Windows 3.1, and a 386 command line executable for DOS built using Zortech C++ v3.1. All four executables are capable of utilizing extended memory

  5. Climate Forecast System Version 2 (CFSv2) Operational Forecasts

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Climate Forecast System Version 2 (CFSv2) produced by the NOAA National Centers for Environmental Prediction (NCEP) is a fully coupled model representing the...

  6. Climate Forecast System Version 2 (CFSv2) Operational Analysis

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Climate Forecast System Version 2 (CFSv2) produced by the NOAA National Centers for Environmental Prediction (NCEP) is a fully coupled model representing the...

  7. CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (IBM PC VERSION)

    Science.gov (United States)

    Riley, G.

    1994-01-01

    The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

  8. CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (MACINTOSH VERSION)

    Science.gov (United States)

    Culbert, C.

    1994-01-01

    The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

  9. Algal Supply System Design - Harmonized Version

    Energy Technology Data Exchange (ETDEWEB)

    Jared Abodeely; Daniel Stevens; Allison Ray; Debor

    2013-03-01

    The objective of this design report is to provide an assessment of current technologies used for production, dewatering, and converting microalgae cultivated in open-pond systems to biofuel. The original draft design was created in 2011 and has subsequently been brought into agreement with the DOE harmonized model. The design report extends beyond this harmonized model to discuss some of the challenges with assessing algal production systems, including the ability to (1) quickly assess alternative algal production system designs, (2) assess spatial and temporal variability, and (3) perform large-scale assessments considering multiple scenarios for thousands of potential sites. The Algae Logistics Model (ALM) was developed to address each of these limitations of current modeling efforts to enable assessment of the economic feasibility of algal production systems across the United States. The (ALM) enables (1) dynamic assessments using spatiotemporal conditions, (2) exploration of algal production system design configurations, (3) investigation of algal production system operating assumptions, and (4) trade-off assessments with technology decisions and operating assumptions. The report discusses results from the ALM, which is used to assess the baseline design determined by harmonization efforts between U.S. DOE national laboratories. Productivity and resource assessment data is provided by coupling the ALM with the Biomass Assessment Tool developed at PNNL. This high-fidelity data is dynamically passed to the ALM and used to help better understand the impacts of spatial and temporal constraints on algal production systems by providing a cost for producing extracted algal lipids annually for each potential site.

  10. Divergent Quiescent Transition Systems (extended version)

    NARCIS (Netherlands)

    Stokkink, W.G.J.; Timmer, Mark; Stoelinga, Mariëlle Ida Antoinette

    Quiescence is a fundamental concept in modelling system behaviour, as it explicitly represents the fact that no output is produced in certain states. The notion of quiescence is also essential to model-based testing: if a particular implementation under test does not provide any output, then the

  11. MULTIPLE PROJECTIONS SYSTEM (MPS) - USER'S MANUAL VERSION 1.0

    Science.gov (United States)

    The report is a user's manual for version 1.0 of the Multiple Projections Systems (MPS), a computer system that can perform "what if" scenario analysis and report the final results (i.e., Rate of Further Progress - ROP - inventories) to EPA (i.e., the Aerometric Information Retri...

  12. Tandem Mirror Reactor Systems Code (Version I)

    International Nuclear Information System (INIS)

    Reid, R.L.; Finn, P.A.; Gohar, M.Y.

    1985-09-01

    A computer code was developed to model a Tandem Mirror Reactor. Ths is the first Tandem Mirror Reactor model to couple, in detail, the highly linked physics, magnetics, and neutronic analysis into a single code. This report describes the code architecture, provides a summary description of the modules comprising the code, and includes an example execution of the Tandem Mirror Reactor Systems Code. Results from this code for two sensitivity studies are also included. These studies are: (1) to determine the impact of center cell plasma radius, length, and ion temperature on reactor cost and performance at constant fusion power; and (2) to determine the impact of reactor power level on cost

  13. Medications (for IBS)

    Medline Plus

    Full Text Available ... treatment of IBS symptoms is not linked to depression, but rather likely to effects on the brain ... problem arises requiring an expert’s care. © Copyright 1998-2018 International Foundation for Functional Gastrointestinal Disorders, Inc. (IFFGD). ...

  14. Medications (for IBS)

    Medline Plus

    Full Text Available ... include bran or psyllium. Anticholinergics/Antispasmodics – have limited benefit for treating IBS. In some persons they relieve abdominal pain or discomfort, usually if the symptoms occur soon after eating. Examples include dicyclomine (Bentyl), and hyoscyamine (Levsin). Read ...

  15. Medications (for IBS)

    Medline Plus

    Full Text Available ... treatment of IBS symptoms is not linked to depression, but rather likely to effects on the brain ... whenever a health problem arises requiring an expert’s care. © Copyright 1998-2018 International Foundation for Functional Gastrointestinal ...

  16. Medications (for IBS)

    Medline Plus

    Full Text Available ... IFFGD Our Mission Awareness Activities Advocacy Activities Research Leadership Industry Council Contact us IBS Treatment Working With ... We advise seeing a physician whenever a health problem arises requiring an expert’s care. © Copyright 1998-2018 ...

  17. Medications (for IBS)

    Medline Plus

    Full Text Available ... of a physician. Read more about laxatives. Bulking agents – provided they relieve and don’t worsen symptoms, can ease stool passage. Examples include bran or psyllium. Anticholinergics/Antispasmodics – have limited benefit for treating IBS. In some persons they relieve ...

  18. IDC System Specification Document Version 1.1.

    Energy Technology Data Exchange (ETDEWEB)

    Harris, James M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lober, Randall R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-02-01

    This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris V1.1 2/2015 IDC Reengineering Project Team Iteration I2 Review Comments M. Harris

  19. PC version of PRIS (Power Reactor Information System)

    International Nuclear Information System (INIS)

    Fukala, J.; Stanik, Z.; White, D.

    1990-05-01

    The IAEA has been collecting operating experience data on nuclear power plants in the Member States since 1970. In 1980 a computerized database was established, the IAEA Power Reactor Information System (PRIS). To make PRIS data available to the Member States in a more convenient format, the development of a PC version of PRIS started in 1989

  20. Rock Visualization System. Technical description (RVS version 3.8)

    International Nuclear Information System (INIS)

    Curtis, P.; Elfstroem, M.; Markstroem, I.

    2007-06-01

    The Rock Visualization System (RVS) has been developed by SKB for use in visualizing geological and engineering data in 3D. The purpose of this report is to provide a technical description of RVS aimed at potential program users and interested parties as well as fulfilling the function of a more general RVS reference that can be cited when writing other technical reports. The report describes RVS version 4.0. Updated versions of this report or addenda will be made available following further development of RVS and the release of subsequent versions of the program. The report covers the following main items: Technical description of the program with illustrations and examples. Limitations of the program and of functionality. For most RVS functions step-by-step tutorials are available describing how a particular function can be used to carry out a specific task. A complete set of updated tutorials is issued with each new version release of the RVS program. However, the tutorials do not cover all the possible uses of all the individual functions but rather give an overall view of their functionality. A detailed description of every RVS function and how it can be used is included in the RVS online Help system

  1. Rock Visualization System. Technical description (RVS version 3.8)

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, P.; Elfstroem, M.; Markstroem, I. [FB Engineering, Goeteborg (Sweden)

    2005-04-01

    The Rock Visualization System (RVS) has been developed by SKB for use in visualizing geological and engineering data in 3D. The purpose of this report is to provide a technical description of RVS aimed at potential program users and interested parties as well as fulfilling the function of a more general RVS reference that can be cited when writing other technical reports. The report describes RVS version 3.8. Updated versions of this report or addenda will be made available following further development of RVS and the release of subsequent versions of the program. The report covers the following main items: Technical description of the program with illustrations and examples. Limitations of the program and of functionality. For most RVS functions step-by-step tutorials are available describing how a particular function can be used to carryout a specific task. A complete set of updated tutorials is issued with each new version release of the RVS program. However, the tutorials do not cover all the possible uses of all the individual functions but rather give an overall view of their functionality. A detailed description of every RVS function and how it can be used is included in the RVS online Help system.

  2. Rock Visualization System. Technical description (RVS version 3.8)

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, P.; Elfstroem, M.; Markstroem, I. [Golder Associates AB (Sweden)

    2007-06-15

    The Rock Visualization System (RVS) has been developed by SKB for use in visualizing geological and engineering data in 3D. The purpose of this report is to provide a technical description of RVS aimed at potential program users and interested parties as well as fulfilling the function of a more general RVS reference that can be cited when writing other technical reports. The report describes RVS version 4.0. Updated versions of this report or addenda will be made available following further development of RVS and the release of subsequent versions of the program. The report covers the following main items: Technical description of the program with illustrations and examples. Limitations of the program and of functionality. For most RVS functions step-by-step tutorials are available describing how a particular function can be used to carry out a specific task. A complete set of updated tutorials is issued with each new version release of the RVS program. However, the tutorials do not cover all the possible uses of all the individual functions but rather give an overall view of their functionality. A detailed description of every RVS function and how it can be used is included in the RVS online Help system.

  3. Rock Visualization System. Technical description (RVS version 3.8)

    International Nuclear Information System (INIS)

    Curtis, P.; Elfstroem, M.; Markstroem, I.

    2005-04-01

    The Rock Visualization System (RVS) has been developed by SKB for use in visualizing geological and engineering data in 3D. The purpose of this report is to provide a technical description of RVS aimed at potential program users and interested parties as well as fulfilling the function of a more general RVS reference that can be cited when writing other technical reports. The report describes RVS version 3.8. Updated versions of this report or addenda will be made available following further development of RVS and the release of subsequent versions of the program. The report covers the following main items: Technical description of the program with illustrations and examples. Limitations of the program and of functionality. For most RVS functions step-by-step tutorials are available describing how a particular function can be used to carryout a specific task. A complete set of updated tutorials is issued with each new version release of the RVS program. However, the tutorials do not cover all the possible uses of all the individual functions but rather give an overall view of their functionality. A detailed description of every RVS function and how it can be used is included in the RVS online Help system

  4. Endocannabinoid and cannabinoid-like fatty acid amide levels correlate with pain-related symptoms in patients with IBS-D and IBS-C: a pilot study.

    Directory of Open Access Journals (Sweden)

    Jakub Fichna

    Full Text Available AIMS: Irritable bowel syndrome (IBS is a functional gastrointestinal (GI disorder, associated with alterations of bowel function, abdominal pain and other symptoms related to the GI tract. Recently the endogenous cannabinoid system (ECS was shown to be involved in the physiological and pathophysiological control of the GI function. The aim of this pilot study was to investigate whether IBS defining symptoms correlate with changes in endocannabinoids or cannabinoid like fatty acid levels in IBS patients. METHODS: AEA, 2-AG, OEA and PEA plasma levels were determined in diarrhoea-predominant (IBS-D and constipation-predominant (IBS-C patients and were compared to healthy subjects, following the establishment of correlations between biolipid contents and disease symptoms. FAAH mRNA levels were evaluated in colonic biopsies from IBS-D and IBS-C patients and matched controls. RESULTS: Patients with IBS-D had higher levels of 2AG and lower levels of OEA and PEA. In contrast, patients with IBS-C had higher levels of OEA. Multivariate analysis found that lower PEA levels are associated with cramping abdominal pain. FAAH mRNA levels were lower in patients with IBS-C. CONCLUSION: IBS subtypes and their symptoms show distinct alterations of endocannabinoid and endocannabinoid-like fatty acid levels. These changes may partially result from reduced FAAH expression. The here reported changes support the notion that the ECS is involved in the pathophysiology of IBS and the development of IBS symptoms.

  5. The NJOY Nuclear Data Processing System, Version 2016

    Energy Technology Data Exchange (ETDEWEB)

    Macfarlane, Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Muir, Douglas W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Boicourt, R. M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kahler, III, Albert Comstock [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Conlin, Jeremy Lloyd [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-01-09

    The NJOY Nuclear Data Processing System, version 2016, is a comprehensive computer code package for producing pointwise and multigroup cross sections and related quantities from evaluated nuclear data in the ENDF-4 through ENDF-6 legacy card-image formats. NJOY works with evaluated files for incident neutrons, photons, and charged particles, producing libraries for a wide variety of particle transport and reactor analysis codes.

  6. topIb, a phylogenetic hallmark gene of Thaumarchaeota encodes a functional eukaryote-like topoisomerase IB.

    Science.gov (United States)

    Dahmane, Narimane; Gadelle, Danièle; Delmas, Stéphane; Criscuolo, Alexis; Eberhard, Stephan; Desnoues, Nicole; Collin, Sylvie; Zhang, Hongliang; Pommier, Yves; Forterre, Patrick; Sezonov, Guennadi

    2016-04-07

    Type IB DNA topoisomerases can eliminate torsional stresses produced during replication and transcription. These enzymes are found in all eukaryotes and a short version is present in some bacteria and viruses. Among prokaryotes, the long eukaryotic version is only observed in archaea of the phylum Thaumarchaeota. However, the activities and the roles of these topoisomerases have remained an open question. Here, we demonstrate that all available thaumarchaeal genomes contain a topoisomerase IB gene that defines a monophyletic group closely related to the eukaryotic enzymes. We show that the topIB gene is expressed in the model thaumarchaeon Nitrososphaera viennensis and we purified the recombinant enzyme from the uncultivated thaumarchaeon Candidatus Caldiarchaeum subterraneum. This enzyme is active in vitro at high temperature, making it the first thermophilic topoisomerase IB characterized so far. We have compared this archaeal type IB enzyme to its human mitochondrial and nuclear counterparts. The archaeal enzyme relaxes both negatively and positively supercoiled DNA like the eukaryotic enzymes. However, its pattern of DNA cleavage specificity is different and it is resistant to camptothecins (CPTs) and non-CPT Top1 inhibitors, LMP744 and lamellarin D. This newly described thermostable topoisomerases IB should be a promising new model for evolutionary, mechanistic and structural studies. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  7. How to Maintain Computerized Procedure System in the same Version

    International Nuclear Information System (INIS)

    Jung, Yeon Sub

    2016-01-01

    CPS(Computerized Procedure System) has been introduced in advanced nuclear power plant worldwide. Korean CPS complies with this trend. It has been applied to Shinkori3,4 and all their successors including BNPP1,2,3,4. CPS is designed by KHNP CRI, and developed by Westinghouse or Doosan. Initial design has been improved by reflecting operator experience, human factor V and V, and advanced engineering method. Design improvement makes CPS differ from plant to plant. For example CPS in Shinhanul cannot interpret CP(Computerized Procedure) of ShinKori3, 4. Different CPS makes it difficult to utilize CP and train operators. Therefore it is important to keep CPS in single version. Note that typical text editors in the office are kept in single version. On the other hand, plant monitoring systems in main control room are actually different. Because CPS is positioned between text editor and monitoring system, goal to maintain CPS in single version is not an easy task. From Shinkori3,4, lots of improvements are achieved in CPS. This improvement surely makes operation easy and will not introduce human errors. Side effect of improvement is that PXS and CPS ES may not be compatible among nuclear power plants. So the side effect should be avoided by minimizing change of XML. Initial XML had been developed for Shinkori3,4. The XML has been modified slightly for Shinhanul1,2. PXS and CPS ES are being developed for the same version for all nuclear power plants of APR1400

  8. Trigonometric version of quantum–classical duality in integrable systems

    Directory of Open Access Journals (Sweden)

    M. Beketov

    2016-02-01

    Full Text Available We extend the quantum–classical duality to the trigonometric (hyperbolic case. The duality establishes an explicit relationship between the classical N-body trigonometric Ruijsenaars–Schneider model and the inhomogeneous twisted XXZ spin chain on N sites. Similarly to the rational version, the spin chain data fixes a certain Lagrangian submanifold in the phase space of the classical integrable system. The inhomogeneity parameters are equal to the coordinates of particles while the velocities of classical particles are proportional to the eigenvalues of the spin chain Hamiltonians (residues of the properly normalized transfer matrix. In the rational version of the duality, the action variables of the Ruijsenaars–Schneider model are equal to the twist parameters with some multiplicities defined by quantum (occupation numbers. In contrast to the rational version, in the trigonometric case there is a splitting of the spectrum of action variables (eigenvalues of the classical Lax matrix. The limit corresponding to the classical Calogero–Sutherland system and quantum trigonometric Gaudin model is also described as well as the XX limit to free fermions.

  9. Trigonometric version of quantum–classical duality in integrable systems

    Energy Technology Data Exchange (ETDEWEB)

    Beketov, M., E-mail: beketov@phystech.edu [MIPT, Inststitutskii per. 9, 141700, Dolgoprudny, Moscow region (Russian Federation); Liashyk, A., E-mail: a.liashyk@gmail.com [National Research University Higher School of Economics, Myasnitskaya str. 20, 101000, Moscow (Russian Federation); BITP, Metrolohichna str. 14-b, 03680, Kiev (Ukraine); Zabrodin, A., E-mail: zabrodin@itep.ru [National Research University Higher School of Economics, Myasnitskaya str. 20, 101000, Moscow (Russian Federation); Institute of Biochemical Physics, Kosygina str. 4, 119991, Moscow (Russian Federation); ITEP, Bolshaya Cheremushkinskaya str. 25, 117218, Moscow (Russian Federation); Zotov, A., E-mail: zotov@mi.ras.ru [Steklov Mathematical Institute, RAS, Gubkina str. 8, 119991, Moscow (Russian Federation); ITEP, Bolshaya Cheremushkinskaya str. 25, 117218, Moscow (Russian Federation); MIPT, Inststitutskii per. 9, 141700, Dolgoprudny, Moscow region (Russian Federation)

    2016-02-15

    We extend the quantum–classical duality to the trigonometric (hyperbolic) case. The duality establishes an explicit relationship between the classical N-body trigonometric Ruijsenaars–Schneider model and the inhomogeneous twisted XXZ spin chain on N sites. Similarly to the rational version, the spin chain data fixes a certain Lagrangian submanifold in the phase space of the classical integrable system. The inhomogeneity parameters are equal to the coordinates of particles while the velocities of classical particles are proportional to the eigenvalues of the spin chain Hamiltonians (residues of the properly normalized transfer matrix). In the rational version of the duality, the action variables of the Ruijsenaars–Schneider model are equal to the twist parameters with some multiplicities defined by quantum (occupation) numbers. In contrast to the rational version, in the trigonometric case there is a splitting of the spectrum of action variables (eigenvalues of the classical Lax matrix). The limit corresponding to the classical Calogero–Sutherland system and quantum trigonometric Gaudin model is also described as well as the XX limit to free fermions.

  10. The FORTRAN-77 version of the Karlsruhe program system KAPROS

    International Nuclear Information System (INIS)

    Moritz, N.

    1985-02-01

    The FORTRAN-77 KAPROS-kernel includes some major changes compared with the version, which is described in the KfK-report 2254. The changes are documented in this report from the point of view of the system-programmer. This report is meant to be a supplement to the KfK-report 2254, assuming that the reader of this report is familiar with the KfK-report 2254. He also should be familiar with the IBM operating system MVS SP1.3.2 and the usual terms of data processing. (orig.) [de

  11. SHABERTH - ANALYSIS OF A SHAFT BEARING SYSTEM (CRAY VERSION)

    Science.gov (United States)

    Coe, H. H.

    1994-01-01

    shear forces in the inlet zone of lubricated contacts, which accounts for the degree of lubricant film starvation; modeling normal and friction forces between a ball and a cage pocket, which account for the transition between the hydrodynamic and elastohydrodynamic regimes of lubrication; and a model of the effect on fatigue life of the ratio of the EHD plateau film thickness to the composite surface roughness. SHABERTH is intended to be as general as possible. The models in SHABERTH allow for the complete mathematical simulation of real physical systems. Systems are limited to a maximum of five bearings supporting the shaft, a maximum of thirty rolling elements per bearing, and a maximum of one hundred temperature nodes. The SHABERTH program structure is modular and has been designed to permit refinement and replacement of various component models as the need and opportunities develop. A preprocessor is included in the IBM PC version of SHABERTH to provide a user friendly means of developing SHABERTH models and executing the resulting code. The preprocessor allows the user to create and modify data files with minimal effort and a reduced chance for errors. Data is utilized as it is entered; the preprocessor then decides what additional data is required to complete the model. Only this required information is requested. The preprocessor can accommodate data input for any SHABERTH compatible shaft bearing system model. The system may include ball bearings, roller bearings, and/or tapered roller bearings. SHABERTH is written in FORTRAN 77, and two machine versions are available from COSMIC. The CRAY version (LEW-14860) has a RAM requirement of 176K of 64 bit words. The IBM PC version (MFS-28818) is written for IBM PC series and compatible computers running MS-DOS, and includes a sample MS-DOS executable. For execution, the PC version requires at least 1Mb of RAM and an 80386 or 486 processor machine with an 80x87 math co-processor. The standard distribution medium for the

  12. Development and validation of the irritable bowel syndrome scale under the system of quality of life instruments for chronic diseases QLICD-IBS: combinations of classical test theory and generalizability theory.

    Science.gov (United States)

    Lei, Pingguang; Lei, Guanghe; Tian, Jianjun; Zhou, Zengfen; Zhao, Miao; Wan, Chonghua

    2014-10-01

    This paper is aimed to develop the irritable bowel syndrome (IBS) scale of the system of Quality of Life Instruments for Chronic Diseases (QLICD-IBS) by the modular approach and validate it by both classical test theory and generalizability theory. The QLICD-IBS was developed based on programmed decision procedures with multiple nominal and focus group discussions, in-depth interview, and quantitative statistical procedures. One hundred twelve inpatients with IBS were used to provide the data measuring QOL three times before and after treatments. The psychometric properties of the scale were evaluated with respect to validity, reliability, and responsiveness employing correlation analysis, factor analyses, multi-trait scaling analysis, t tests and also G studies and D studies of generalizability theory analysis. Multi-trait scaling analysis, correlation, and factor analyses confirmed good construct validity and criterion-related validity when using SF-36 as a criterion. Test-retest reliability coefficients (Pearson r and intra-class correlation (ICC)) for the overall score and all domains were higher than 0.80; the internal consistency α for all domains at two measurements were higher than 0.70 except for the social domain (0.55 and 0.67, respectively). The overall score and scores for all domains/facets had statistically significant changes after treatments with moderate or higher effect size standardized response mean (SRM) ranging from 0.72 to 1.02 at domain levels. G coefficients and index of dependability (Ф coefficients) confirmed the reliability of the scale further with more exact variance components. The QLICD-IBS has good validity, reliability, responsiveness, and some highlights and can be used as the quality of life instrument for patients with IBS.

  13. 6 Tips: IBS and Complementary Health Practices

    Science.gov (United States)

    ... health practice for IBS, here are 6 tips: Hypnotherapy (hypnosis). This practice involves the power of suggestion by ... IBS. According to reviews of the scientific literature, hypnotherapy may be a helpful treatment for managing IBS ...

  14. TRASYS - THERMAL RADIATION ANALYZER SYSTEM (DEC VAX VERSION WITH NASADIG)

    Science.gov (United States)

    Anderson, G. E.

    1994-01-01

    The Thermal Radiation Analyzer System, TRASYS, is a computer software system with generalized capability to solve the radiation related aspects of thermal analysis problems. TRASYS computes the total thermal radiation environment for a spacecraft in orbit. The software calculates internode radiation interchange data as well as incident and absorbed heat rate data originating from environmental radiant heat sources. TRASYS provides data of both types in a format directly usable by such thermal analyzer programs as SINDA/FLUINT (available from COSMIC, program number MSC-21528). One primary feature of TRASYS is that it allows users to write their own driver programs to organize and direct the preprocessor and processor library routines in solving specific thermal radiation problems. The preprocessor first reads and converts the user's geometry input data into the form used by the processor library routines. Then, the preprocessor accepts the user's driving logic, written in the TRASYS modified FORTRAN language. In many cases, the user has a choice of routines to solve a given problem. Users may also provide their own routines where desirable. In particular, the user may write output routines to provide for an interface between TRASYS and any thermal analyzer program using the R-C network concept. Input to the TRASYS program consists of Options and Edit data, Model data, and Logic Flow and Operations data. Options and Edit data provide for basic program control and user edit capability. The Model data describe the problem in terms of geometry and other properties. This information includes surface geometry data, documentation data, nodal data, block coordinate system data, form factor data, and flux data. Logic Flow and Operations data house the user's driver logic, including the sequence of subroutine calls and the subroutine library. Output from TRASYS consists of two basic types of data: internode radiation interchange data, and incident and absorbed heat rate data

  15. TRASYS - THERMAL RADIATION ANALYZER SYSTEM (DEC VAX VERSION WITHOUT NASADIG)

    Science.gov (United States)

    Vogt, R. A.

    1994-01-01

    The Thermal Radiation Analyzer System, TRASYS, is a computer software system with generalized capability to solve the radiation related aspects of thermal analysis problems. TRASYS computes the total thermal radiation environment for a spacecraft in orbit. The software calculates internode radiation interchange data as well as incident and absorbed heat rate data originating from environmental radiant heat sources. TRASYS provides data of both types in a format directly usable by such thermal analyzer programs as SINDA/FLUINT (available from COSMIC, program number MSC-21528). One primary feature of TRASYS is that it allows users to write their own driver programs to organize and direct the preprocessor and processor library routines in solving specific thermal radiation problems. The preprocessor first reads and converts the user's geometry input data into the form used by the processor library routines. Then, the preprocessor accepts the user's driving logic, written in the TRASYS modified FORTRAN language. In many cases, the user has a choice of routines to solve a given problem. Users may also provide their own routines where desirable. In particular, the user may write output routines to provide for an interface between TRASYS and any thermal analyzer program using the R-C network concept. Input to the TRASYS program consists of Options and Edit data, Model data, and Logic Flow and Operations data. Options and Edit data provide for basic program control and user edit capability. The Model data describe the problem in terms of geometry and other properties. This information includes surface geometry data, documentation data, nodal data, block coordinate system data, form factor data, and flux data. Logic Flow and Operations data house the user's driver logic, including the sequence of subroutine calls and the subroutine library. Output from TRASYS consists of two basic types of data: internode radiation interchange data, and incident and absorbed heat rate data

  16. TRASYS - THERMAL RADIATION ANALYZER SYSTEM (CRAY VERSION WITH NASADIG)

    Science.gov (United States)

    Anderson, G. E.

    1994-01-01

    The Thermal Radiation Analyzer System, TRASYS, is a computer software system with generalized capability to solve the radiation related aspects of thermal analysis problems. TRASYS computes the total thermal radiation environment for a spacecraft in orbit. The software calculates internode radiation interchange data as well as incident and absorbed heat rate data originating from environmental radiant heat sources. TRASYS provides data of both types in a format directly usable by such thermal analyzer programs as SINDA/FLUINT (available from COSMIC, program number MSC-21528). One primary feature of TRASYS is that it allows users to write their own driver programs to organize and direct the preprocessor and processor library routines in solving specific thermal radiation problems. The preprocessor first reads and converts the user's geometry input data into the form used by the processor library routines. Then, the preprocessor accepts the user's driving logic, written in the TRASYS modified FORTRAN language. In many cases, the user has a choice of routines to solve a given problem. Users may also provide their own routines where desirable. In particular, the user may write output routines to provide for an interface between TRASYS and any thermal analyzer program using the R-C network concept. Input to the TRASYS program consists of Options and Edit data, Model data, and Logic Flow and Operations data. Options and Edit data provide for basic program control and user edit capability. The Model data describe the problem in terms of geometry and other properties. This information includes surface geometry data, documentation data, nodal data, block coordinate system data, form factor data, and flux data. Logic Flow and Operations data house the user's driver logic, including the sequence of subroutine calls and the subroutine library. Output from TRASYS consists of two basic types of data: internode radiation interchange data, and incident and absorbed heat rate data

  17. Versioning for CMIP6 in the Earth System Grid Federation

    Science.gov (United States)

    Weigel, Tobias; Kindermann, Stephan; Lautenschlager, Michael

    2015-04-01

    The Earth System Grid Federation (ESGF) has been used as the e-infrastructure to provide access to CMIP5 data and is expected to serve CMIP6 data as well. 2015 marks the year of continued planning and preparation where new concepts can still be implemented for the operational phase of CMIP6. A particular concern within ESGF operations is the versioning and automated replication of data. From CMIP5 experience we know that the pathway between initial submission of modelling data to the ESGF data space and quality-controlled long-term archival of the final products is long and far from linear. Data may be retracted, amended and updated, and metadata may accumulate at different stages. It is unrealistic to assume that a simple and straightforward process can be used as a role model to build ESGF services around the different stages data will pass through during the active phase of CMIP6. Nonetheless, at the technical level ESGF requires some form of automated control and management. At the same time, the accountability of data products must be made transparent to guard against misinterpretation, increase user experience and promote open and reproducible science. To address the challenges, first some essential versioning policies must be agreed upon and enforced through technical means and organizational processes. The volatile readiness state of CMIP data cannot be changed as it is given by the users; however its management can be improved. A promising approach is to embed persistent identifiers in all CMIP6 data objects and register them so they can be globally resolved by any user and used as reference points within ESGF management processes. A specific conceptual interpretation and management of such identifiers can ensure that they remain valid and useful even if the data objects change or become unavailable. For this, identifiers must be assigned to individual versions and aggregations, connected with each other and integrated in the existing ESGF publication

  18. A CMMS Expert using BIM for IBS Building Maintenance

    Directory of Open Access Journals (Sweden)

    Hamzah Noraini

    2016-01-01

    Full Text Available In the IBS building maintenance, the conventional methods to the project delivery and its failure to form effective communication channel between complementary knowledge on IBS construction and related members that is conducted in the sequential manner has resulted in ineffectiveness for managing building maintenance, where a paradigm shift within the IBS traditional approach is necessary. The research results described are concerned with i an integrated system to record, diagnose and analyse information for IBS building maintenance to detect patent or latent defect, select an effective repair method, provide appropriate planning decision and reduce risks of defect throughout the building lifetime. ii building a decision making support in diagnosis in IBS building maintenance based on robust data collection about concrete defects and causes including in the selection of a durable replacement design and material or the proper rehabilitation method. The system development was based on analysis of number of interviews and case studies conducted with professional engineers working in IBS building maintenance departments. The paper concludes that implementing a CMMS Expert using BIM can help improve the performance of IBS building design, construction and maintenance operations.

  19. A new version of transfer matrix method for multibody systems

    Energy Technology Data Exchange (ETDEWEB)

    Rui, Xiaoting, E-mail: ruixt@163.net [Nanjing University of Science and Technology, Institute of Launch Dynamics (China); Bestle, Dieter, E-mail: bestle@b-tu.de [Brandenburg University of Technology, Engineering Mechanics and Vehicle Dynamics (Germany); Zhang, Jianshu, E-mail: zhangdracpa@sina.com; Zhou, Qinbo, E-mail: zqb912-new@163.com [Nanjing University of Science and Technology, Institute of Launch Dynamics (China)

    2016-10-15

    In order to avoid the global dynamics equations and increase the computational efficiency for multibody system dynamics (MSD), the transfer matrix method of multibody system (MSTMM) has been developed and applied very widely in research and engineering in recent 20 years. It differs from ordinary methods in multibody system dynamics with respect to the feature that there is no need for a global dynamics equation, and it uses low-order matrices for high computational efficiency. For linear systems, MSTMM is exact even if continuous elements like beams are involved. The discrete time MSTMM, however, has to use local linearization. In order to release the method from such approximations, a new version of MSTMM is presented in this paper where translational and angular accelerations, on the one hand, and internal forces and moments, on the other hand, are used as state variables. Already linear relationships among these quantities are utilized, which results in new element transfer matrices and algorithms making the study of multibody systems as simple as the study of single bodies. The proposed approach also allows combining MSTMM with any general numerical integration procedure. Some numerical examples of MSD are given to demonstrate the proposed method.

  20. Key factors of successful JIT integration with IBS - An overview

    Science.gov (United States)

    Asri, Mohammad Azwanie Naim Mohammad; Nawi, Mohd Nasrun Mohd; Nadarajan, Santhirasegaran

    2016-08-01

    The Just-In-Time (JIT) philosophy has been used for many decades to increase productivity through waste elimination process. The purpose of this paper is to contribute to the knowledge by addressing the transportation and material delivery activities in Industrialized Building System (IBS) and integrating JIT to improve the performance of those activities. The literature review has been conducted through relevant database. It was found that there is a need for more holistic approach to be adopted to integrate JIT in IBS project. This paper discusses the key success factors for effective integration between JIT and IBS in the context of transportation and material delivery activities.

  1. CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (DEC VAX VMS VERSION)

    Science.gov (United States)

    Donnell, B.

    1994-01-01

    command line version. For the UNIX version of CLIPS 6.0, the command line interface has been successfully implemented on a Sun4 running SunOS, a DECstation running DEC RISC ULTRIX, an SGI Indigo Elan running IRIX, a DEC Alpha AXP running OSF/1, and an IBM RS/6000 running AIX. Command line interface executables are included for Sun4 computers running SunOS 4.1.1 or later and for the DEC RISC ULTRIX platform. The makefiles may have to be modified slightly to be used on other UNIX platforms. The UNIX, Macintosh, and IBM PC versions of CLIPS 6.0 each have a platform specific interface. Source code, a makefile, and an executable for the Windows 3.1 interface version of CLIPS 6.0 are provided only on the IBM PC distribution diskettes. Source code, a makefile, and an executable for the Macintosh interface version of CLIPS 6.0 are provided only on the Macintosh distribution diskettes. Likewise, for the UNIX version of CLIPS 6.0, only source code and a makefile for an X-Windows interface are provided. The X-Windows interface requires MIT's X Window System, Version 11, Release 4 (X11R4), the Athena Widget Set, and the Xmu library. The source code for the Athena Widget Set is provided on the distribution medium. The X-Windows interface has been successfully implemented on a Sun4 running SunOS 4.1.2 with the MIT distribution of X11R4 (not OpenWindows), an SGI Indigo Elan running IRIX 4.0.5, and a DEC Alpha AXP running OSF/1 1.2. The VAX version of CLIPS 6.0 comes only with the generic command line interface. ASCII makefiles for the command line version of CLIPS are provided on all the distribution media for UNIX, VMS, and DOS. Four executables are provided with the IBM PC version: a windowed interface executable for Windows 3.1 built using Borland C++ v3.1, an editor for use with the windowed interface, a command line version of CLIPS for Windows 3.1, and a 386 command line executable for DOS built using Zortech C++ v3.1. All four executables are capable of utilizing extended memory

  2. TWOS - TIME WARP OPERATING SYSTEM, VERSION 2.5.1

    Science.gov (United States)

    Bellenot, S. F.

    1994-01-01

    The Time Warp Operating System (TWOS) is a special-purpose operating system designed to support parallel discrete-event simulation. TWOS is a complete implementation of the Time Warp mechanism, a distributed protocol for virtual time synchronization based on process rollback and message annihilation. Version 2.5.1 supports simulations and other computations using both virtual time and dynamic load balancing; it does not support general time-sharing or multi-process jobs using conventional message synchronization and communication. The program utilizes the underlying operating system's resources. TWOS runs a single simulation at a time, executing it concurrently on as many processors of a distributed system as are allocated. The simulation needs only to be decomposed into objects (logical processes) that interact through time-stamped messages. TWOS provides transparent synchronization. The user does not have to add any more special logic to aid in synchronization, nor give any synchronization advice, nor even understand much about how the Time Warp mechanism works. The Time Warp Simulator (TWSIM) subdirectory contains a sequential simulation engine that is interface compatible with TWOS. This means that an application designer and programmer who wish to use TWOS can prototype code on TWSIM on a single processor and/or workstation before having to deal with the complexity of working on a distributed system. TWSIM also provides statistics about the application which may be helpful for determining the correctness of an application and for achieving good performance on TWOS. Version 2.5.1 has an updated interface that is not compatible with 2.0. The program's user manual assists the simulation programmer in the design, coding, and implementation of discrete-event simulations running on TWOS. The manual also includes a practical user's guide to the TWOS application benchmark, Colliding Pucks. TWOS supports simulations written in the C programming language. It is designed

  3. Version E2 from Dimco-System for the statistical calculation of components

    International Nuclear Information System (INIS)

    Moreno Gonzalez, A.

    1981-01-01

    A short description of the general system Dimco, together with a detailed description of E2 version are presented. E2 version is a two-dimensional finite element structural code. To illustrate the posibilities of E2 version, some results obtained with this new version are presented. These results are related with the following behaviour of the material: a) elastic, b) thermo-elastic, c) Plastic and d) creep. (author)

  4. WASTES: Waste System Transportation and Economic Simulation--Version 2:

    International Nuclear Information System (INIS)

    Sovers, R.A.; Shay, M.R.; Ouderkirk, S.J.; McNair, G.W.; Eagle, B.G.

    1988-02-01

    The Waste System Transportation and Economic Simulation (WASTES) Technical Reference Manual was written to describe and document the algorithms used within the WASTES model as implemented in Version 2.23. The manual will serve as a reference for users of the WASTES system. The intended audience for this manual are knowledgeable users of WASTES who have an interest in the underlying principles and algorithms used within the WASTES model. Each algorithm is described in nonprogrammers terminology, and the source and uncertainties of the constants in use by these algorithms are described. The manual also describes the general philosophy and rules used to: 1) determine the allocation and priority of spent fuel generation sources to facility destinations, 2) calculate transportation costs, and 3) estimate the cost of at-reactor ex-pool storage. A detailed description of the implementation of many of the algorithms is also included in the WASTES Programmers Reference Manual (Shay and Buxbaum 1986a). This manual is separated into sections based on the general usage of the algorithms being discussed. 8 refs., 14 figs., 2 tabs

  5. Development of AIJ Design Analysis and Modules System Version V

    International Nuclear Information System (INIS)

    Yamaguchi, Daisuke

    2017-01-01

    IHI Corp. continues to develop ADAMS system as a steel structure analysis program of nuclear power plant. This paper introduces its latest version, ADAMS-V, with a focus on the development concept, system configuration, and analysis functions. Without changing the reliability of NEWADAMS, which achieved satisfactory results as a structural analysis program for large structures and piping support structures, ADAMS-V abolished command line input and text manipulation on the workstation, enabled intuitive operation via GUI on multiple personal terminals, and switched the analysis input work to the input mainly based on screen display. In addition, it enabled complicated evaluation when multiple loads act on the structure, as well as the evaluation of design evaluation items such as (1) consideration of friction load, (2) local buckling evaluation, (3) architectural hardware evaluation, (4) rigidity evaluation, and (5) welded part evaluation. In addition, it has achieved more efficient work than in the past by forming the common database in collaboration with 3D-CAD shift ISAP and LUNA developed by IHI. (A.O.)

  6. Innovative Approach for IBS Vendor Selection Problem

    Directory of Open Access Journals (Sweden)

    Omar Mohd Faizal

    2016-01-01

    Full Text Available Supply chain management in Industrialised Building System (IBS construction management has significantly determined the successful of company and project performance. Due to the wide variety of criteria and vendor available, the vendor selection process for a specific project needs is becoming more difficult. The need of decision aid for vendor selection in other areas is widely discussed in previous research. However, study on vendor selection for IBS project is largely neglected. Decision Support System (DSS is proposed for this purpose. Yet, most of the DSS models are impractical since they are complicated and difficult for a layman such as project managers to use. Research indicates that the rapid development of ICT has highly potential towards simple and effective DSS. Thus, this paper highlights the importance and research approach for vendor selection in IBS project management. The study is based on Design Science Research Methodology with combination of case studies. It is anticipates that this study will yield an effective value-for-money decision making platform to manage vendor selection process.

  7. IB Offering Certificate for Careers

    Science.gov (United States)

    Robelen, Erik W.

    2012-01-01

    The International Baccalaureate (IB) organization, best known in the United States for its prestigious two-year diploma program for juniors and seniors, will enter new terrain this fall as it formally rolls out an initiative centered on a variety of career pathways that includes engineering, culinary arts, and automotive technology. The move comes…

  8. IBS and Non-GI Functional Disorders

    Science.gov (United States)

    ... of IBS patients have at least one coexisting somatic symptom and many IBS patients meet diagnostic criteria ... up-to-date on the latest news, stories, tips, research highlights, and more! Sign up for eNewsletter: ...

  9. BehavePlus fire modeling system, version 5.0: Variables

    Science.gov (United States)

    Patricia L. Andrews

    2009-01-01

    This publication has been revised to reflect updates to version 4.0 of the BehavePlus software. It was originally published as the BehavePlus fire modeling system, version 4.0: Variables in July, 2008.The BehavePlus fire modeling system is a computer program based on mathematical models that describe wildland fire behavior and effects and the...

  10. Release Early, Release Often: Predicting Change in Versioned Knowledge Organization Systems on the Web

    OpenAIRE

    Meroño-Peñuela, Albert; Guéret, Christophe; Schlobach, Stefan

    2015-01-01

    The Semantic Web is built on top of Knowledge Organization Systems (KOS) (vocabularies, ontologies, concept schemes) that provide a structured, interoperable and distributed access to Linked Data on the Web. The maintenance of these KOS over time has produced a number of KOS version chains: subsequent unique version identifiers to unique states of a KOS. However, the release of new KOS versions pose challenges to both KOS publishers and users. For publishers, updating a KOS is a knowledge int...

  11. The mathematical statement for the solving of the problem of N-version software system design

    Science.gov (United States)

    Kovalev, I. V.; Kovalev, D. I.; Zelenkov, P. V.; Voroshilova, A. A.

    2015-10-01

    The N-version programming, as a methodology of the fault-tolerant software systems design, allows successful solving of the mentioned tasks. The use of N-version programming approach turns out to be effective, since the system is constructed out of several parallel executed versions of some software module. Those versions are written to meet the same specification but by different programmers. The problem of developing an optimal structure of N-version software system presents a kind of very complex optimization problem. This causes the use of deterministic optimization methods inappropriate for solving the stated problem. In this view, exploiting heuristic strategies looks more rational. In the field of pseudo-Boolean optimization theory, the so called method of varied probabilities (MVP) has been developed to solve problems with a large dimensionality.

  12. Functional Expression of a DNA-Topoisomerase IB from Cryptosporidium parvum

    Directory of Open Access Journals (Sweden)

    César Ordóñez

    2009-01-01

    Full Text Available Cryptosporidium parvum, one of the most important causative organisms of human diarrheas during childhood, contains a monomeric DNA-topoisomerase IB (CpTopIB in chromosome 7. Heterologous expression of CpTopIB gene in a budding yeast strain lacking this activity proves that the cryptosporidial enzyme is functional in vivo. The enzymatic activity is comprised in a single polypeptide, which contains all the structural features defining a fully active TopIB. Relaxation activity of the yeast extracts was detected only when CpTopIB ORF was expressed in a yeast expression system showing time and protein dependence under steady state kinetic conditions. The susceptibility of CpTopIB-transformed yeast to the irreversible inhibitor camptothecin and its water-soluble derivatives (topotecan and SN-38 was assessed.

  13. Generation and tests of the new version 88 library for HAMMER system

    International Nuclear Information System (INIS)

    Chalhoub, E.S.; Anaf, J.

    1988-08-01

    A new library, version 88, for the HAMMER system, was generated using the ENDF/B-IV FRENDL evaluated nuclear data libraries. It is composed of epithermal and thermal libraries obtained by processing the new versions of ETOG-3 and FLANGE-II codes, respectively. Test results for two benchmark critical assemblies are presented. (author) [pt

  14. A Systems Engineering Capability Maturity Model, Version 1.1,

    Science.gov (United States)

    1995-11-01

    of a sequence of actions to be taken to perform a given task. [SECMM] 1. A set of activities ( ISO 12207 ). 2. A set of practices that address the...standards One of the design goals of the SE-CMM effort was to capture the salient concepts from emerging standards and initiatives (e.g.; ISO 9001...history for the SE-CMM: Version Designator Content Change Notes Release 1 • architecture rationale • Process Areas • ISO (SPICE) BPG 0.05 summary

  15. PROBLEM OF SUPPORTING THE VERSIONS OF DISTANCE EDUCATION SYSTEM MOODLE IN THE MEDICAL UNIVERSITY

    Directory of Open Access Journals (Sweden)

    Andrii V. Semenets

    2014-01-01

    Full Text Available Moodle is one of the open-source software learning management system using to support an educational process. The problem of updating the outdated Moodle versions is studied in the article. It is shown a successful implementation of a modified version on the basis of I. Ya. Horbachevsky Ternopil State Medical University. The step-by-step manual of the updating and a new server migration process are described. Examples of the application of the virtualization techniques and version control system to the SDE Moodle system administration tasks solving are presented. The SDE Moodle server optimization and customization recommendations are also given.

  16. An antisense peptide nucleic acid against Pseudomonas aeruginosa inhibiting bacterial-induced inflammatory responses in the cystic fibrosis IB3-1 cellular model system

    DEFF Research Database (Denmark)

    Montagner, Giulia; Bezzerri, Valentino; Cabrini, Giulio

    2017-01-01

    of the essential acpP gene of P. aeruginosa, and previously shown to inhibit bacterial growth, concomitantly also strongly inhibits induced up-regulation of the pro-inflammatory markers IL-8, IL-6, G-CSF, IFN-γ, IP-10, MCP-1 and TNF-α in IB3-1 cystic fibrosis cells infected by P. aeruginosa PAO1. Remarkably...... are significant considering the key role of this protein in the cystic fibrosis inflammatory process exacerbated by P. aeruginosa infection....

  17. System Analysis and Risk Assessment system (SARA) Version 4.0

    International Nuclear Information System (INIS)

    Sattison, M.B.; Russell, K.D.; Skinner, N.L.

    1992-01-01

    This NUREG is the tutorial for the System Analysis and Risk Assessment System (SARA) Version 4.0, a microcomputer-based system used to analyze the safety issues of a family [i.e., a power plant, a manufacturing facility, any facility on which a probabilistic risk assessment (PRA) might be performed]. A series of lessons are provided that walk the user through some basic steps common to most analyses performed with SARA. The example problems presented in the lessons build on one another, and in combination, lead the user through all aspects of SARA sensitivity analysis

  18. Integrated Farm System Model Version 4.3 and Dairy Gas Emissions Model Version 3.3 Software development and distribution

    Science.gov (United States)

    Modeling routines of the Integrated Farm System Model (IFSM version 4.2) and Dairy Gas Emission Model (DairyGEM version 3.2), two whole-farm simulation models developed and maintained by USDA-ARS, were revised with new components for: (1) simulation of ammonia (NH3) and greenhouse gas emissions gene...

  19. Timing and control monitor system upgrade design document. Version 4

    International Nuclear Information System (INIS)

    Brandt, J.J.

    1984-01-01

    This is a design document for the Timing and Control Monitor System Upgrade Project. This project is intended to provide a replacement system for the existing user Encoder Monitor Systems and Varian 72 Control Room computer systems. All of these systems reside at the Nevada Test Site. The function of the T and C Monitor System is to gather real-time statistics and data on user defined key variables from control, communication, data acquistion systems, and from the monitoring system itself. The control, communication, and data acquisition systems each operate separately from the monitor system. The T and C Monitor System gathers this data in order to verify the readiness of an event to begin countdown. This includes setup, verification, calibration, and peripheral services, report any failures that may occur during the countdown, verify detonation and containment, and assist reentry activities after the event

  20. CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (IBM PC VERSION WITH CLIPSITS)

    Science.gov (United States)

    Riley, , .

    1994-01-01

    The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

  1. Operating system design the Xinu approach, Linksys version

    CERN Document Server

    Press, CRC

    2011-01-01

    Introduction and OverviewOperating SystemsApproach Used In The TextA Hierarchical DesignThe Xinu Operating SystemWhat An Operating System Is NotAn Operating System Viewed From The OutsideRemainder Of The TextConcurrent Execution And Operating System ServicesProgramming Models For Multiple ActivitiesOperating System ServicesConcurrent Processing Concepts And TerminologyDistinction Between Sequential And Concurrent ProgramsMultiple Processes Sharing A Single Piece Of CodeProcess Exit And Process TerminationShared Memory, Race Conditions, And SynchronizationSemaphores And Mutual ExclusionType Nam

  2. Steamer Training System and Graphics Editor, 1987 Version

    Science.gov (United States)

    1987-09-01

    NIIHAU : >simenv>documentation>simenv-read me.text.24 7/30/87 18:29:51 Page 1 SMode: Text-- Herewith are instructions for installing the Genera 7.0 (should...lowercase: t; package: file-system; - (set-logical-pathname-host "simenv" : physical-host " niihau " :translations ((C"simenv;" ">3imenv>") steamer-system...translations ;;--- mode: lisp; base: 10; lowercase: t; package: file-system;-- (fS:set-logical-pathname-host "steamer-system" :physical-host " niihau

  3. Uniform System for the Evaluation of Substances (USES), version 4.0

    NARCIS (Netherlands)

    Linders JBHJ; Rikken MGJ; Bakker J; Poel P van der; CSR

    2002-01-01

    This report describes the fouth version of the Uniform System for the Evaluation of Substances, USES 4.0. USES 4.0 is an integrated risk assessment system for new and existing substances and agricultural and non-agricultural pesticides. The risk assessment system for new and existing substances in

  4. Ross Ice Drainage System (RIDS) Glaciochemical Analysis, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — The Ross Ice Drainage System (RIDS) project provides a high-resolution record of atmospheric chemical deposition taken from several ice cores and snow pits located...

  5. National Weather Service (NWS) Station Information System (SIS), Version 2

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — National Weather Service (NWS) Station Information System (SIS) contains observing station metadata from November 2016 to present. These are renditions are used for...

  6. Time Warp Operating System, Version 2.5.1

    Science.gov (United States)

    Bellenot, Steven F.; Gieselman, John S.; Hawley, Lawrence R.; Peterson, Judy; Presley, Matthew T.; Reiher, Peter L.; Springer, Paul L.; Tupman, John R.; Wedel, John J., Jr.; Wieland, Frederick P.; hide

    1993-01-01

    Time Warp Operating System, TWOS, is special purpose computer program designed to support parallel simulation of discrete events. Complete implementation of Time Warp software mechanism, which implements distributed protocol for virtual synchronization based on rollback of processes and annihilation of messages. Supports simulations and other computations in which both virtual time and dynamic load balancing used. Program utilizes underlying resources of operating system. Written in C programming language.

  7. Time warp operating system version 2.7 internals manual

    Science.gov (United States)

    1992-01-01

    The Time Warp Operating System (TWOS) is an implementation of the Time Warp synchronization method proposed by David Jefferson. In addition, it serves as an actual platform for running discrete event simulations. The code comprising TWOS can be divided into several different sections. TWOS typically relies on an existing operating system to furnish some very basic services. This existing operating system is referred to as the Base OS. The existing operating system varies depending on the hardware TWOS is running on. It is Unix on the Sun workstations, Chrysalis or Mach on the Butterfly, and Mercury on the Mark 3 Hypercube. The base OS could be an entirely new operating system, written to meet the special needs of TWOS, but, to this point, existing systems have been used instead. The base OS's used for TWOS on various platforms are not discussed in detail in this manual, as they are well covered in their own manuals. Appendix G discusses the interface between one such OS, Mach, and TWOS.

  8. An integrable noncommutative version of the sine-Gordon system

    International Nuclear Information System (INIS)

    Grisaru, Marcus T.; Penati, Silvia

    2003-01-01

    Using the bicomplex approach we discuss an integrable noncommutative system in two-dimensional Euclidean space. It is described by an equation of motion which reduces to the ordinary sine-Gordon equation when the noncommutation parameter is removed, plus a constraint equation which is nontrivial only in the noncommutative case. The implications of this constraint, which is required by integrability but seems to reduce the space of classical solutions, remain to be understood. We show that the system has an infinite number of conserved currents and we give the general recursive relation for constructing them. For the particular cases of lower spin nontrivial currents we work out the explicit expressions and perform a direct check of their conservation. These currents reduce to the usual sine-Gordon currents in the commutative limit. We find classical 'localized' solutions to first order in the noncommutativity parameter and describe the Backlund transformations for our system. Finally, we comment on the relation of our noncommutative system to the commutative sine-Gordon system

  9. Platelet Glycoprotein Ib-IX and Malignancy

    Science.gov (United States)

    2010-09-01

    provide a unique microenvironment supporting the accumulation of more platelets and the elaboration of a fibrin - rich network produced by coagulation...process and can initiate the formation of a platelet - rich thrombus by tethering the platelet to a thrombogenic surface. Several ligands binding to GP Ib... Platelet Glycoprotein Ib-IX and Malignancy PRINCIPAL INVESTIGATOR: Jerry Ware, Ph.D

  10. The ``KILDER`` air pollution modelling system, version 2.0

    Energy Technology Data Exchange (ETDEWEB)

    Gram, F.

    1996-12-31

    This report describes the KILDER Air Pollution Modelling System, which is a system of small PC-programs for calculation of long-term emission, dispersion, concentration and exposure from different source categories. The system consists of three parts: (1) The dispersion models POI-KILD and ARE-KILD for point- and area-sources, respectively, (2) Meterological programs WINDFREC, STABFREC and METFREC, (3) Supporting programs for calculating emissions and exposure and for operating with binary data fields. The file structure is based on binary files with data fields. The data fields are matrices with different types of values and may be read into the computer or be calculated in other programs. 19 refs., 22 figs., 3 tabs.

  11. The FSE system for crop simulation, version 2.1

    NARCIS (Netherlands)

    Kraalingen, van D.W.G.

    1995-01-01

    A FORTRAN 77 programming environment for continuous simulation of agro-ecological processes, such as crop growth and calculation of water balances is presented. This system, called FSE (FORTRAN Simulation Environment), consists of a main program, weather data and utilities for performing specific

  12. Basic Graphical Data Management System (BAGDAMS version 1.0)

    International Nuclear Information System (INIS)

    Weindorf, J.W.

    1979-06-01

    BAGDAMS (BAsic Graphical DAta Management System) is a set of FORTRAN callable subroutines which provides mass storage data structuring and manipulation capabilities. Although primarily designed to facilitate the handling of graphical data files (files containing information to be displayed upon graphical hardware devices), BAGDAMS can also be used in many other applications requiring complex mass storage resident data structures. (author)

  13. IBS for non-gaussian distributions

    International Nuclear Information System (INIS)

    Fedotov, A.; Sidorin, A.O.; Smirnov, A.V.

    2010-01-01

    In many situations distribution can significantly deviate from Gaussian which requires accurate treatment of IBS. Our original interest in this problem was motivated by the need to have an accurate description of beam evolution due to IBS while distribution is strongly affected by the external electron cooling force. A variety of models with various degrees of approximation were developed and implemented in BETACOOL in the past to address this topic. A more complete treatment based on the friction coefficient and full 3-D diffusion tensor was introduced in BETACOOL at the end of 2007 under the name 'local IBS model'. Such a model allowed us calculation of IBS for an arbitrary beam distribution. The numerical benchmarking of this local IBS algorithm and its comparison with other models was reported before. In this paper, after briefly describing the model and its limitations, they present its comparison with available experimental data.

  14. The NJOY nuclear data processing system Version 91

    International Nuclear Information System (INIS)

    MacFarlane, R.E.; Muir, D.W.

    1994-10-01

    The NJOY nuclear data processing system is a comprehensive computer code package for producing pointwise and multigroup cross sections and related quantities from elevated nuclear data in the ENDF format, including the latest US library, ENDF/B-VI. The NJOY code can work with neutrons, photons, and charged particles, and it can produce libraries for a wide variety of particle transport and reactor analysis codes

  15. Latest version of the Munich pulsed low energy positron system

    International Nuclear Information System (INIS)

    Bauer-Kugelmann, W.; Sperr, P.; Koegel, G.; Triftshaeuser, W.

    2001-01-01

    Further improvements of the Munich pulsed low energy positron system have been performed. A new chopper, configured as a double plate deflection system with an external resonator and a new buncher working like a classical double gap buncher, are implemented. The complete rf-power electronic was redesigned and operates now at an overall master-frequency of 50 MHz for all bunching and chopping components. A new target station with an enlarged Faraday cage is installed. The sample temperature is variable between 30 K and 600 K. Up to ten samples can be stored in a magazine and transferred under vacuum conditions to the measuring position. With a primary source of 30 mCi 22 Na a count rate of up to 4 kHz can be achieved with a peak-to-background ratio of 3000:1. This ratio can be further improved by the use of a Wien filter. A beam diameter of about 2 mm was determined. The total time resolution (pulsing plus detector system) is 250 ps (FWHM). (orig.)

  16. Open Energy Information System version 2.0

    Energy Technology Data Exchange (ETDEWEB)

    2017-09-26

    OpenEIS was created to provide standard methods for authoring, sharing, testing, using, and improving algorithms for operational building energy efficiency with building managers and building owners. OpenEIS is designed as a no-cost/low-cost solution that will propagate the fault detection and diagnostic (FDD) solutions into the marketplace by providing state- of- the-art analytical and diagnostic algorithms. As OpenEIS penetrates the market, demand by control system manufacturers and integrators serving small and medium commercial customers will help push these types of commercial software tool offerings into the broader marketplace.

  17. ERRORJ. Covariance processing code system for JENDL. Version 2

    International Nuclear Information System (INIS)

    Chiba, Gou

    2003-09-01

    ERRORJ is the covariance processing code system for Japanese Evaluated Nuclear Data Library (JENDL) that can produce group-averaged covariance data to apply it to the uncertainty analysis of nuclear characteristics. ERRORJ can treat the covariance data for cross sections including resonance parameters as well as angular distributions and energy distributions of secondary neutrons which could not be dealt with by former covariance processing codes. In addition, ERRORJ can treat various forms of multi-group cross section and produce multi-group covariance file with various formats. This document describes an outline of ERRORJ and how to use it. (author)

  18. Physical habitat simulation system reference manual: version II

    Science.gov (United States)

    Milhous, Robert T.; Updike, Marlys A.; Schneider, Diane M.

    1989-01-01

    There are four major components of a stream system that determine the productivity of the fishery (Karr and Dudley 1978). These are: (1) flow regime, (2) physical habitat structure (channel form, substrate distribution, and riparian vegetation), (3) water quality (including temperature), and (4) energy inputs from the watershed (sediments, nutrients, and organic matter). The complex interaction of these components determines the primary production, secondary production, and fish population of the stream reach. The basic components and interactions needed to simulate fish populations as a function of management alternatives are illustrated in Figure I.1. The assessment process utilizes a hierarchical and modular approach combined with computer simulation techniques. The modular components represent the "building blocks" for the simulation. The quality of the physical habitat is a function of flow and, therefore, varies in quality and quantity over the range of the flow regime. The conceptual framework of the Incremental Methodology and guidelines for its application are described in "A Guide to Stream Habitat Analysis Using the Instream Flow Incremental Methodology" (Bovee 1982). Simulation of physical habitat is accomplished using the physical structure of the stream and streamflow. The modification of physical habitat by temperature and water quality is analyzed separately from physical habitat simulation. Temperature in a stream varies with the seasons, local meteorological conditions, stream network configuration, and the flow regime; thus, the temperature influences on habitat must be analysed on a stream system basis. Water quality under natural conditions is strongly influenced by climate and the geological materials, with the result that there is considerable natural variation in water quality. When we add the activities of man, the possible range of water quality possibilities becomes rather large. Consequently, water quality must also be analysed on a

  19. Generalized Fluid System Simulation Program (GFSSP) - Version 6

    Science.gov (United States)

    Majumdar, Alok; LeClair, Andre; Moore, Ric; Schallhorn, Paul

    2015-01-01

    The Generalized Fluid System Simulation Program (GFSSP) is a finite-volume based general-purpose computer program for analyzing steady state and time-dependent flow rates, pressures, temperatures, and concentrations in a complex flow network. The program is capable of modeling real fluids with phase changes, compressibility, mixture thermodynamics, conjugate heat transfer between solid and fluid, fluid transients, pumps, compressors, flow control valves and external body forces such as gravity and centrifugal. The thermo-fluid system to be analyzed is discretized into nodes, branches, and conductors. The scalar properties such as pressure, temperature, and concentrations are calculated at nodes. Mass flow rates and heat transfer rates are computed in branches and conductors. The graphical user interface allows users to build their models using the 'point, drag, and click' method; the users can also run their models and post-process the results in the same environment. The integrated fluid library supplies thermodynamic and thermo-physical properties of 36 fluids, and 24 different resistance/source options are provided for modeling momentum sources or sinks in the branches. Users can introduce new physics, non-linear and time-dependent boundary conditions through user-subroutine.

  20. Generalized Fluid System Simulation Program, Version 5.0-Educational

    Science.gov (United States)

    Majumdar, A. K.

    2011-01-01

    The Generalized Fluid System Simulation Program (GFSSP) is a finite-volume based general-purpose computer program for analyzing steady state and time-dependent flow rates, pressures, temperatures, and concentrations in a complex flow network. The program is capable of modeling real fluids with phase changes, compressibility, mixture thermodynamics, conjugate heat transfer between solid and fluid, fluid transients, pumps, compressors and external body forces such as gravity and centrifugal. The thermofluid system to be analyzed is discretized into nodes, branches, and conductors. The scalar properties such as pressure, temperature, and concentrations are calculated at nodes. Mass flow rates and heat transfer rates are computed in branches and conductors. The graphical user interface allows users to build their models using the point, drag and click method; the users can also run their models and post-process the results in the same environment. The integrated fluid library supplies thermodynamic and thermo-physical properties of 36 fluids and 21 different resistance/source options are provided for modeling momentum sources or sinks in the branches. This Technical Memorandum illustrates the application and verification of the code through 12 demonstrated example problems.

  1. Generalized Fluid System Simulation Program, Version 6.0

    Science.gov (United States)

    Majumdar, A. K.; LeClair, A. C.; Moore, R.; Schallhorn, P. A.

    2016-01-01

    The Generalized Fluid System Simulation Program (GFSSP) is a general purpose computer program for analyzing steady state and time-dependent flow rates, pressures, temperatures, and concentrations in a complex flow network. The program is capable of modeling real fluids with phase changes, compressibility, mixture thermodynamics, conjugate heat transfer between solid and fluid, fluid transients, pumps, compressors, and external body forces such as gravity and centrifugal. The thermofluid system to be analyzed is discretized into nodes, branches, and conductors. The scalar properties such as pressure, temperature, and concentrations are calculated at nodes. Mass flow rates and heat transfer rates are computed in branches and conductors. The graphical user interface allows users to build their models using the 'point, drag, and click' method; the users can also run their models and post-process the results in the same environment. Two thermodynamic property programs (GASP/WASP and GASPAK) provide required thermodynamic and thermophysical properties for 36 fluids: helium, methane, neon, nitrogen, carbon monoxide, oxygen, argon, carbon dioxide, fluorine, hydrogen, parahydrogen, water, kerosene (RP-1), isobutene, butane, deuterium, ethane, ethylene, hydrogen sulfide, krypton, propane, xenon, R-11, R-12, R-22, R-32, R-123, R-124, R-125, R-134A, R-152A, nitrogen trifluoride, ammonia, hydrogen peroxide, and air. The program also provides the options of using any incompressible fluid with constant density and viscosity or ideal gas. The users can also supply property tables for fluids that are not in the library. Twenty-four different resistance/source options are provided for modeling momentum sources or sinks in the branches. These options include pipe flow, flow through a restriction, noncircular duct, pipe flow with entrance and/or exit losses, thin sharp orifice, thick orifice, square edge reduction, square edge expansion, rotating annular duct, rotating radial duct

  2. System software for the NMFECC CRAY-1 version of GIFTS 4B

    International Nuclear Information System (INIS)

    Gray, W.H.; Baudry, T.V.

    1981-01-01

    The Oak Ridge National Laboratory (ORNL) maintains a version of the GIFTS system structural analysis computer programs. Executable modules are supported on two different types of computer hardware, a DECsystem-10 and a CRAY-1. Without external difference to the user, these modules execute equivalently upon both types of hardware. Presented herein are the local software enhancements for the ORNL version of GIFTS for the National Magnetic Fusion Energy Computer Center (NMFECC) CRAY-1 computer as well as a description of the ORNL implementation of the system-dependent portions of the GIFTS software library for the NMFECC CRAY-1

  3. System Analysis and Risk Assessment System (SARA), Version 4.0

    International Nuclear Information System (INIS)

    Russell, K.D.; Sattison, M.B.; Skinner, N.L.; Stewart, H.D.; Wood, S.T.

    1992-02-01

    This NUREG is the reference manual for the System Analysis and Risk Assessment (SARA) System Version 4.0, a microcomputer-based system used to analyze the safety issues of a family [i.e., a power plant, a manufacturing facility, any facility on which a probabilistic risk assessment (PRA) might be performed]. The SARA data base contains PRA data for the dominant accident sequences of a family and descriptive information about the family including event trees, fault trees, and system model diagrams. The number of facility data bases that can be accessed is limited only by the amount of disk storage available. To simulate changes to family systems, SARA users change the failure rates of initiating and basic events and/or modify the structure of the cut sets that make up the event trees, fault trees, and systems. The user then evaluates the effects of these changes through the recalculation of the resultant accident sequence probabilities and importance measures. The results are displayed in tables and graphs

  4. System cost model user's manual, version 1.2

    International Nuclear Information System (INIS)

    Shropshire, D.

    1995-06-01

    The System Cost Model (SCM) was developed by Lockheed Martin Idaho Technologies in Idaho Falls, Idaho and MK-Environmental Services in San Francisco, California to support the Baseline Environmental Management Report sensitivity analysis for the U.S. Department of Energy (DOE). The SCM serves the needs of the entire DOE complex for treatment, storage, and disposal (TSD) of mixed low-level, low-level, and transuranic waste. The model can be used to evaluate total complex costs based on various configuration options or to evaluate site-specific options. The site-specific cost estimates are based on generic assumptions such as waste loads and densities, treatment processing schemes, existing facilities capacities and functions, storage and disposal requirements, schedules, and cost factors. The SCM allows customization of the data for detailed site-specific estimates. There are approximately forty TSD module designs that have been further customized to account for design differences for nonalpha, alpha, remote-handled, and transuranic wastes. The SCM generates cost profiles based on the model default parameters or customized user-defined input and also generates costs for transporting waste from generators to TSD sites

  5. Nuclear Engine System Simulation (NESS). Version 2.0: Program user's guide. Final Report

    International Nuclear Information System (INIS)

    Pelaccio, D.G.; Scheil, C.M.; Petrosky, L.

    1993-03-01

    This Program User's Guide discusses the Nuclear Thermal Propulsion (NTP) engine system design features and capabilities modeled in the Nuclear Engine System Simulation (NESS): Version 2.0 program (referred to as NESS throughout the remainder of this document), as well as its operation. NESS was upgraded to include many new modeling capabilities not available in the original version delivered to NASA LeRC in Dec. 1991, NESS's new features include the following: (1) an improved input format; (2) an advanced solid-core NERVA-type reactor system model (ENABLER 2); (3) a bleed-cycle engine system option; (4) an axial-turbopump design option; (5) an automated pump-out turbopump assembly sizing option; (6) an off-design gas generator engine cycle design option; (7) updated hydrogen properties; (8) an improved output formnd (9) personal computer operation capability. Sample design cases are presented in the user's guide that demonstrate many of the new features associated with this upgraded version of NESS, as well as design modeling features associated with the original version of NESS

  6. A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis.

    LENUS (Irish Health Repository)

    Suppiah, Ravi

    2011-05-01

    Assessment of disease activity in vasculitis can be achieved using the BVAS, a clinical checklist of relevant symptoms, signs and features of active disease. The aim of this study was to revalidate the BVAS version 3 (BVAS v. 3) in a cohort of patients with systemic vasculitis.

  7. STATE ACID RAIN RESEARCH AND SCREENING SYSTEM - VERSION 1.0 USER'S MANUAL

    Science.gov (United States)

    The report is a user's manual that describes Version 1.0 of EPA's STate Acid Rain Research and Screening System (STARRSS), developed to assist utility regulatory commissions in reviewing utility acid rain compliance plans. It is a screening tool that is based on scenario analysis...

  8. Integrated Reliability and Risk Analysis System (IRRAS) Version 2.0 user's guide

    International Nuclear Information System (INIS)

    Russell, K.D.; Sattison, M.B.; Rasmuson, D.M.

    1990-06-01

    The Integrated Reliability and Risk Analysis System (IRRAS) is a state-of-the-art, microcomputer-based probabilistic risk assessment (PRA) model development and analysis tool to address key nuclear plant safety issues. IRRAS is an integrated software tool that gives the user the ability to create and analyze fault trees and accident sequences using a microcomputer. This program provides functions that range from graphical fault tree construction to cut set generation and quantification. Also provided in the system is an integrated full-screen editor for use when interfacing with remote mainframe computer systems. Version 1.0 of the IRRAS program was released in February of 1987. Since that time, many user comments and enhancements have been incorporated into the program providing a much more powerful and user-friendly system. This version has been designated IRRAS 2.0 and is the subject of this user's guide. Version 2.0 of IRRAS provides all of the same capabilities as Version 1.0 and adds a relational data base facility for managing the data, improved functionality, and improved algorithm performance. 9 refs., 292 figs., 4 tabs

  9. Integrals for IBS and Beam Cooling

    International Nuclear Information System (INIS)

    Burov, A.

    2005-01-01

    Simulation of beam cooling usually requires performing certain integral transformations every time step or so, which is a significant burden on the CPU. Examples are the dispersion integrals (Hilbert transforms) in the stochastic cooling, wake fields and IBS integrals. An original method is suggested for fast and sufficiently accurate computation of the integrals. This method is applied for the dispersion integral. Some methodical aspects of the IBS analysis are discussed

  10. Description of surface systems. Preliminary site description Simpevarp sub area - Version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Lindborg, Tobias [ed.

    2005-03-01

    Swedish Nuclear Fuel and Waste Management Co is currently conducting site characterisation in the Simpevarp area. The area is divided into two subareas, the Simpevarp and the Laxemar subarea. The two subareas are surrounded by a common regional model area, the Simpevarp area. This report describes both the regional area and the subareas. This report is an interim version (model version 1.2) of the description of the surface systems at the Simpevarp area, and should be seen as a background report to the site description of the Simpevarp area, version 1.2, SKB-R--05-08. The basis for this description is quality-assured field data available in the SKB SICADA and GIS databases, together with generic data from the literature. The Surface system, here defined as everything above the bedrock, comprises a number of separate disciplines (e.g. hydrology, geology, topography, oceanography and ecology). Each discipline has developed descriptions and models for a number of properties that together represent the site description. The current methodology for developing the surface system description and the integration to ecosystem models is documented in a methodology strategy report SKB-R--03-06. The procedures and guidelines given in that report were followed in this report. Compared with version 1.1 of the surface system description SKB-R--04-25, this report presents considerable additional features, especially in the ecosystem description (Chapter 4) and in the description of the surface hydrology (Section 3.4). A first attempt has also been made to connect the flow of matter (carbon) between the different ecosystems into an overall ecosystem model at a landscape level. A summarised version of this report is also presented in SKB-R--05-08 together with geological-, hydrogeological-, transport properties-, thermal properties-, rock mechanics- and hydrogeochemical descriptions.

  11. Description of surface systems. Preliminary site description Simpevarp sub area - Version 1.2

    International Nuclear Information System (INIS)

    Lindborg, Tobias

    2005-03-01

    Swedish Nuclear Fuel and Waste Management Co is currently conducting site characterisation in the Simpevarp area. The area is divided into two subareas, the Simpevarp and the Laxemar subarea. The two subareas are surrounded by a common regional model area, the Simpevarp area. This report describes both the regional area and the subareas. This report is an interim version (model version 1.2) of the description of the surface systems at the Simpevarp area, and should be seen as a background report to the site description of the Simpevarp area, version 1.2, SKB-R--05-08. The basis for this description is quality-assured field data available in the SKB SICADA and GIS databases, together with generic data from the literature. The Surface system, here defined as everything above the bedrock, comprises a number of separate disciplines (e.g. hydrology, geology, topography, oceanography and ecology). Each discipline has developed descriptions and models for a number of properties that together represent the site description. The current methodology for developing the surface system description and the integration to ecosystem models is documented in a methodology strategy report SKB-R--03-06. The procedures and guidelines given in that report were followed in this report. Compared with version 1.1 of the surface system description SKB-R--04-25, this report presents considerable additional features, especially in the ecosystem description (Chapter 4) and in the description of the surface hydrology (Section 3.4). A first attempt has also been made to connect the flow of matter (carbon) between the different ecosystems into an overall ecosystem model at a landscape level. A summarised version of this report is also presented in SKB-R--05-08 together with geological-, hydrogeological-, transport properties-, thermal properties-, rock mechanics- and hydrogeochemical descriptions

  12. Forecasting Wind and Solar Generation: Improving System Operations, Greening the Grid (Spanish Version)

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Tian; Chernyakhovskiy, Ilya; Brancucci Martinez-Anido, Carlo

    2016-04-01

    This document is the Spanish version of 'Greening the Grid- Forecasting Wind and Solar Generation Improving System Operations'. It discusses improving system operations with forecasting with and solar generation. By integrating variable renewable energy (VRE) forecasts into system operations, power system operators can anticipate up- and down-ramps in VRE generation in order to cost-effectively balance load and generation in intra-day and day-ahead scheduling. This leads to reduced fuel costs, improved system reliability, and maximum use of renewable resources.

  13. Uniform System for the Evaluation of Substances (USES), version 4.0

    OpenAIRE

    Linders JBHJ; Rikken MGJ; Bakker J; van der Poel P; CSR

    2002-01-01

    This report describes the fouth version of the Uniform System for the Evaluation of Substances, USES 4.0. USES 4.0 is an integrated risk assessment system for new and existing substances and agricultural and non-agricultural pesticides. The risk assessment system for new and existing substances in USES 4.0 is fully equivalent to EUSES 1.00, the European Union System for the Evaluation of Substances. USES is a decision-support system to be used by central governments, research institutes and t...

  14. Integrated Reliability and Risk Analysis System (IRRAS), Version 2.5: Reference manual

    International Nuclear Information System (INIS)

    Russell, K.D.; McKay, M.K.; Sattison, M.B.; Skinner, N.L.; Wood, S.T.; Rasmuson, D.M.

    1991-03-01

    The Integrated Reliability and Risk Analysis System (IRRAS) is a state-of-the-art, microcomputer-based probabilistic risk assessment (PRA) model development and analysis tool to address key nuclear plant safety issues. IRRAS is an integrated software tool that gives the user the ability to create and analyze fault trees and accident sequences using a microcomputer. This program provides functions that range from graphical fault tree construction to cut set generation and quantification. Version 1.0 of the IRRAS program was released in February of 1987. Since that time, many user comments and enhancements have been incorporated into the program providing a much more powerful and user-friendly system. This version has been designated IRRAS 2.5 and is the subject of this Reference Manual. Version 2.5 of IRRAS provides the same capabilities as Version 1.0 and adds a relational data base facility for managing the data, improved functionality, and improved algorithm performance. 7 refs., 348 figs

  15. The Effects of FreeSurfer Version, Workstation Type, and Macintosh Operating System Version on Anatomical Volume and Cortical Thickness Measurements

    OpenAIRE

    Gronenschild, Ed H. B. M.; Habets, Petra; Jacobs, Heidi I. L.; Mengelers, Ron; Rozendaal, Nico; van Os, Jim; Marcelis, Machteld

    2012-01-01

    FreeSurfer is a popular software package to measure cortical thickness and volume of neuroanatomical structures. However, little if any is known about measurement reliability across various data processing conditions. Using a set of 30 anatomical T1-weighted 3T MRI scans, we investigated the effects of data processing variables such as FreeSurfer version (v4.3.1, v4.5.0, and v5.0.0), workstation (Macintosh and Hewlett-Packard), and Macintosh operating system version (OSX 10.5 and OSX 10.6). S...

  16. Systems analysis programs for hands-on integrated reliability evaluations (SAPHIRE) version 5.0

    International Nuclear Information System (INIS)

    Russell, K.D.; Kvarfordt, K.J.; Skinner, N.L.; Wood, S.T.

    1994-07-01

    The Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE) refers to a set of several microcomputer programs that were developed to create and analyze probabilistic risk assessments (PRAs), primarily for nuclear power plants. This volume is the reference manual for the Systems Analysis and Risk Assessment (SARA) System Version 5.0, a microcomputer-based system used to analyze the safety issues of a open-quotes familyclose quotes [i.e., a power plant, a manufacturing facility, any facility on which a probabilistic risk assessment (PRA) might be performed]. The SARA database contains PRA data primarily for the dominant accident sequences of a family and descriptive information about the family including event trees, fault trees, and system model diagrams. The number of facility databases that can be accessed is limited only by the amount of disk storage available. To simulate changes to family systems, SARA users change the failure rates of initiating and basic events and/or modify the structure of the cut sets that make up the event trees, fault trees, and systems. The user then evaluates the effects of these changes through the recalculation of the resultant accident sequence probabilities and importance measures. The results are displayed in tables and graphs that may be printed for reports. A preliminary version of the SARA program was completed in August 1985 and has undergone several updates in response to user suggestions and to maintain compatibility with the other SAPHIRE programs. Version 5.0 of SARA provides the same capability as earlier versions and adds the ability to process unlimited cut sets; display fire, flood, and seismic data; and perform more powerful cut set editing

  17. Particle and heavy ion transport code system, PHITS, version 2.52

    International Nuclear Information System (INIS)

    Sato, Tatsuhiko; Matsuda, Norihiro; Hashimoto, Shintaro; Iwamoto, Yosuke; Noda, Shusaku; Ogawa, Tatsuhiko; Nakashima, Hiroshi; Fukahori, Tokio; Okumura, Keisuke; Kai, Tetsuya; Niita, Koji; Iwase, Hiroshi; Chiba, Satoshi; Furuta, Takuya; Sihver, Lembit

    2013-01-01

    An upgraded version of the Particle and Heavy Ion Transport code System, PHITS2.52, was developed and released to the public. The new version has been greatly improved from the previously released version, PHITS2.24, in terms of not only the code itself but also the contents of its package, such as the attached data libraries. In the new version, a higher accuracy of simulation was achieved by implementing several latest nuclear reaction models. The reliability of the simulation was improved by modifying both the algorithms for the electron-, positron-, and photon-transport simulations and the procedure for calculating the statistical uncertainties of the tally results. Estimation of the time evolution of radioactivity became feasible by incorporating the activation calculation program DCHAIN-SP into the new package. The efficiency of the simulation was also improved as a result of the implementation of shared-memory parallelization and the optimization of several time-consuming algorithms. Furthermore, a number of new user-support tools and functions that help users to intuitively and effectively perform PHITS simulations were developed and incorporated. Due to these improvements, PHITS is now a more powerful tool for particle transport simulation applicable to various research and development fields, such as nuclear technology, accelerator design, medical physics, and cosmic-ray research. (author)

  18. The development of Version 2 of the AN-SNAP casemix classification system.

    Science.gov (United States)

    Green, Janette; Gordon, Robert

    2007-04-01

    This paper presents the results of a recent review of the Australian National Sub-acute and Non-acute Patient (AN-SNAP) classification system. The AN-SNAP system was developed by the Centre for Health Service Development, University of Wollongong in 1997. The review was conducted between August 2005 and September 2006. Four clinical sub-committees comprising more than 50 clinicians from sub-acute services across New South Wales as well as representatives from Queensland and the Australian Capital Territory were established to develop a set of proposals to be considered for incorporation into Version 2 of the classification. It is proposed that the final AN-SNAP Version 2 classification will be available for implementation from 1 July 2007.

  19. Development of EASYQAD version β: A Visualization Code System for QAD-CGGP-A Gamma and Neutron Shielding Calculation Code

    International Nuclear Information System (INIS)

    Kim, Jae Cheon; Lee, Hwan Soo; Ha, Pham Nhu Viet; Kim, Soon Young; Shin, Chang Ho; Kim, Jong Kyung

    2007-01-01

    EASYQAD had been previously developed by using MATLAB GUI (Graphical User Interface) in order to perform conveniently gamma and neutron shielding calculations at Hanyang University. It had been completed as version α of radiation shielding analysis code. In this study, EASYQAD was upgraded to version β with many additional functions and more user-friendly graphical interfaces. For general users to run it on Windows XP environment without any MATLAB installation, this version was developed into a standalone code system

  20. Concept of Operations for the Next Generation Air Transportation System, Version 2.0

    Science.gov (United States)

    2007-06-13

    instrument flight rules [ IFR ]), and communication with the ANSP via voice radio. In airspace where TBO is used (see Section 2.4), the minimum...GENERATION AIR TRANSPORTATION SYSTEM (NEXTGEN) JOINT PLANNING AND DEVELOPMENT OFFICE 2-32 VERSION 2.0 Transport category IFR -capable rotorcraft...disapproval, or a recommendation to amend the plan to include easements, noise mitigation, and disclosure requirements. The jurisdiction seeking to approve

  1. U.S. Army weapon systems human-computer interface style guide. Version 2

    Energy Technology Data Exchange (ETDEWEB)

    Avery, L.W.; O`Mara, P.A.; Shepard, A.P.; Donohoo, D.T.

    1997-12-31

    A stated goal of the US Army has been the standardization of the human computer interfaces (HCIs) of its system. Some of the tools being used to accomplish this standardization are HCI design guidelines and style guides. Currently, the Army is employing a number of HCI design guidance documents. While these style guides provide good guidance for the command, control, communications, computers, and intelligence (C4I) domain, they do not necessarily represent the more unique requirements of the Army`s real time and near-real time (RT/NRT) weapon systems. The Office of the Director of Information for Command, Control, Communications, and Computers (DISC4), in conjunction with the Weapon Systems Technical Architecture Working Group (WSTAWG), recognized this need as part of their activities to revise the Army Technical Architecture (ATA), now termed the Joint Technical Architecture-Army (JTA-A). To address this need, DISC4 tasked the Pacific Northwest National Laboratory (PNNL) to develop an Army weapon systems unique HCI style guide, which resulted in the US Army Weapon Systems Human-Computer Interface (WSHCI) Style Guide Version 1. Based on feedback from the user community, DISC4 further tasked PNNL to revise Version 1 and publish Version 2. The intent was to update some of the research and incorporate some enhancements. This document provides that revision. The purpose of this document is to provide HCI design guidance for the RT/NRT Army system domain across the weapon systems subdomains of ground, aviation, missile, and soldier systems. Each subdomain should customize and extend this guidance by developing their domain-specific style guides, which will be used to guide the development of future systems within their subdomains.

  2. Development of EASYQAD version β. A visualization code system for gamma and neutron shielding calculations

    International Nuclear Information System (INIS)

    Kim, Jae Cheon; Kim, Soon Young; Lee, Hwan Soo; Ha, Pham Nhu Viet; Kim, Jong Kyung

    2008-01-01

    EASYQAD version β was developed by MATLAB GUI (Graphical User Interface) as a visualization code system based on QAD-CGGP-A point-kernel code for convenient shielding calculations of gammas and neutrons. It consists of four graphic interface modules including GEOMETRY, INPUT, OUTPUT, and SHIELD. These modules were compiled in C++ programming language by using the MATLAB Compiler Toolbox to form a stand-along code system that can be run on the Windows XP operating system without MATLAB installation. In addition, EASYQAD version β has user-friendly graphical interfaces and, additionally, many useful functions in comparison with QAD- CGGP-A such as common material library, line and grid detectors, and multi-group energy calculations so as to increase its applicability in the field of radiation shielding analysis. It is a powerful tool for non-experts to analyze easily the shielding problems without special training. Therefore, EASYOAD version β is expected to contribute effectively to the development of radiation shielding analysis by providing users in medical and industrial fields with an efficient radiation shielding code. (author)

  3. BOLD VENTURE COMPUTATION SYSTEM for nuclear reactor core analysis, Version III

    International Nuclear Information System (INIS)

    Vondy, D.R.; Fowler, T.B.; Cunningham, G.W. III.

    1981-06-01

    This report is a condensed documentation for VERSION III of the BOLD VENTURE COMPUTATION SYSTEM for nuclear reactor core analysis. An experienced analyst should be able to use this system routinely for solving problems by referring to this document. Individual reports must be referenced for details. This report covers basic input instructions and describes recent extensions to the modules as well as to the interface data file specifications. Some application considerations are discussed and an elaborate sample problem is used as an instruction aid. Instructions for creating the system on IBM computers are also given

  4. BOLD VENTURE COMPUTATION SYSTEM for nuclear reactor core analysis, Version III

    Energy Technology Data Exchange (ETDEWEB)

    Vondy, D.R.; Fowler, T.B.; Cunningham, G.W. III.

    1981-06-01

    This report is a condensed documentation for VERSION III of the BOLD VENTURE COMPUTATION SYSTEM for nuclear reactor core analysis. An experienced analyst should be able to use this system routinely for solving problems by referring to this document. Individual reports must be referenced for details. This report covers basic input instructions and describes recent extensions to the modules as well as to the interface data file specifications. Some application considerations are discussed and an elaborate sample problem is used as an instruction aid. Instructions for creating the system on IBM computers are also given.

  5. The effects of FreeSurfer version, workstation type, and Macintosh operating system version on anatomical volume and cortical thickness measurements.

    Science.gov (United States)

    Gronenschild, Ed H B M; Habets, Petra; Jacobs, Heidi I L; Mengelers, Ron; Rozendaal, Nico; van Os, Jim; Marcelis, Machteld

    2012-01-01

    FreeSurfer is a popular software package to measure cortical thickness and volume of neuroanatomical structures. However, little if any is known about measurement reliability across various data processing conditions. Using a set of 30 anatomical T1-weighted 3T MRI scans, we investigated the effects of data processing variables such as FreeSurfer version (v4.3.1, v4.5.0, and v5.0.0), workstation (Macintosh and Hewlett-Packard), and Macintosh operating system version (OSX 10.5 and OSX 10.6). Significant differences were revealed between FreeSurfer version v5.0.0 and the two earlier versions. These differences were on average 8.8 ± 6.6% (range 1.3-64.0%) (volume) and 2.8 ± 1.3% (1.1-7.7%) (cortical thickness). About a factor two smaller differences were detected between Macintosh and Hewlett-Packard workstations and between OSX 10.5 and OSX 10.6. The observed differences are similar in magnitude as effect sizes reported in accuracy evaluations and neurodegenerative studies.The main conclusion is that in the context of an ongoing study, users are discouraged to update to a new major release of either FreeSurfer or operating system or to switch to a different type of workstation without repeating the analysis; results thus give a quantitative support to successive recommendations stated by FreeSurfer developers over the years. Moreover, in view of the large and significant cross-version differences, it is concluded that formal assessment of the accuracy of FreeSurfer is desirable.

  6. The effects of FreeSurfer version, workstation type, and Macintosh operating system version on anatomical volume and cortical thickness measurements.

    Directory of Open Access Journals (Sweden)

    Ed H B M Gronenschild

    Full Text Available FreeSurfer is a popular software package to measure cortical thickness and volume of neuroanatomical structures. However, little if any is known about measurement reliability across various data processing conditions. Using a set of 30 anatomical T1-weighted 3T MRI scans, we investigated the effects of data processing variables such as FreeSurfer version (v4.3.1, v4.5.0, and v5.0.0, workstation (Macintosh and Hewlett-Packard, and Macintosh operating system version (OSX 10.5 and OSX 10.6. Significant differences were revealed between FreeSurfer version v5.0.0 and the two earlier versions. These differences were on average 8.8 ± 6.6% (range 1.3-64.0% (volume and 2.8 ± 1.3% (1.1-7.7% (cortical thickness. About a factor two smaller differences were detected between Macintosh and Hewlett-Packard workstations and between OSX 10.5 and OSX 10.6. The observed differences are similar in magnitude as effect sizes reported in accuracy evaluations and neurodegenerative studies.The main conclusion is that in the context of an ongoing study, users are discouraged to update to a new major release of either FreeSurfer or operating system or to switch to a different type of workstation without repeating the analysis; results thus give a quantitative support to successive recommendations stated by FreeSurfer developers over the years. Moreover, in view of the large and significant cross-version differences, it is concluded that formal assessment of the accuracy of FreeSurfer is desirable.

  7. The Systems Biology Markup Language (SBML: Language Specification for Level 3 Version 2 Core

    Directory of Open Access Journals (Sweden)

    Hucka Michael

    2018-03-01

    Full Text Available Computational models can help researchers to interpret data, understand biological functions, and make quantitative predictions. The Systems Biology Markup Language (SBML is a file format for representing computational models in a declarative form that different software systems can exchange. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 2 of SBML Level 3 Core. The specification defines the data structures prescribed by SBML, their encoding in XML (the eXtensible Markup Language, validation rules that determine the validity of an SBML document, and examples of models in SBML form. The design of Version 2 differs from Version 1 principally in allowing new MathML constructs, making more child elements optional, and adding identifiers to all SBML elements instead of only selected elements. Other materials and software are available from the SBML project website at http://sbml.org/.

  8. The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 2 Core.

    Science.gov (United States)

    Hucka, Michael; Bergmann, Frank T; Dräger, Andreas; Hoops, Stefan; Keating, Sarah M; Le Novère, Nicolas; Myers, Chris J; Olivier, Brett G; Sahle, Sven; Schaff, James C; Smith, Lucian P; Waltemath, Dagmar; Wilkinson, Darren J

    2018-03-09

    Computational models can help researchers to interpret data, understand biological functions, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that different software systems can exchange. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 2 of SBML Level 3 Core. The specification defines the data structures prescribed by SBML, their encoding in XML (the eXtensible Markup Language), validation rules that determine the validity of an SBML document, and examples of models in SBML form. The design of Version 2 differs from Version 1 principally in allowing new MathML constructs, making more child elements optional, and adding identifiers to all SBML elements instead of only selected elements. Other materials and software are available from the SBML project website at http://sbml.org/.

  9. Definition of the Flexible Image Transport System (FITS), version 3.0

    Science.gov (United States)

    Pence, W. D.; Chiappetti, L.; Page, C. G.; Shaw, R. A.; Stobie, E.

    2010-12-01

    The Flexible Image Transport System (FITS) has been used by astronomers for over 30 years as a data interchange and archiving format; FITS files are now handled by a wide range of astronomical software packages. Since the FITS format definition document (the “standard”) was last printed in this journal in 2001, several new features have been developed and standardized, notably support for 64-bit integers in images and tables, variable-length arrays in tables, and new world coordinate system conventions which provide a mapping from an element in a data array to a physical coordinate on the sky or within a spectrum. The FITS Working Group of the International Astronomical Union has therefore produced this new version 3.0 of the FITS standard, which is provided here in its entirety. In addition to describing the new features in FITS, numerous editorial changes were made to the previous version to clarify and reorganize many of the sections. Also included are some appendices which are not formally part of the standard. The FITS standard is likely to undergo further evolution, in which case the latest version may be found on the FITS Support Office Web site at http://fits.gsfc.nasa.gov/, which also provides many links to FITS-related resources.

  10. Definition of the Flexible Image Transport System (FITS), Version 3.0

    Science.gov (United States)

    Pence, W. D.; Chiapetti, L.; Page, C. G.; Shaw, R. A.; Stobie, E.

    2010-01-01

    The Flexible Image Transport System (FITS) has been used by astronomers for over 30 years as a data interchange and archiving format; FITS files are now handled by a wide range of astronomical software packages. Since the FITS format definition document (the "standard") was last printed in this journal in 2001, several new features have been developed and standardized, notably support for 64-bit integers in images and tables, variable-length arrays in tables, and new world coordinate system conventions which provide a mapping from an element in a data array to a physical coordinate on the sky or within a spectrum. The FITS Working Group of the International Astronomical Union has therefore produced this new Version 3.0 of the FITS standard, which is provided here in its entirety. In addition to describing the new features in FITS, numerous editorial changes were made to the previous version to clarify and reorganize many of the sections. Also included are some appendices which are not formally part of the standard. The FITS standard is likely to undergo further evolution, in which case the latest version may be found on the FITS Support Office Web site at http://fits.gsfc.nasa.gov/, which also provides many links to FITS-related resources.

  11. Development of environmental dose assessment system (EDAS) code of PC version

    CERN Document Server

    Taki, M; Kobayashi, H; Yamaguchi, T

    2003-01-01

    A computer code (EDAS) was developed to assess the public dose for the safety assessment to get the license of nuclear reactor operation. This code system is used for the safety analysis of public around the nuclear reactor in normal operation and severe accident. This code was revised and composed for personal computer user according to the Nuclear Safety Guidelines reflected the ICRP1990 recommendation. These guidelines are revised by Nuclear Safety Commission on March, 2001, which are 'Weather analysis guideline for the safety assessment of nuclear power reactor', 'Public dose around the facility assessment guideline corresponding to the objective value for nuclear power light water reactor' and 'Public dose assessment guideline for safety review of nuclear power light water reactor'. This code has been already opened for public user by JAERI, and English version code and user manual are also prepared. This English version code is helpful for international cooperation concerning the nuclear safety assessme...

  12. Methodology for decision making in environmental restoration after nuclear accidents: temas system (version 2.1)

    International Nuclear Information System (INIS)

    Montero, M.; Moraleda, M.; Claver, F.; Vazquez, C.; Gutierrez, J.

    2001-01-01

    TEMAS is an user-friendly decision aiding computerised system to help in the selection of the best local strategy of restoration when a post-accidental environmental contamination with long lived radionuclides (''137 Cs and ''90 Sr) must be faced TEMAS provides answer for complex scenarios on whichever place of the European Community territory ( urban agricultural and forest) with different specific levels of contamination, uses and dimensions. The initial version was the result of the TEMAS project (Techniques and Management Strategies for Environmental Restoration) supported by the EU during the 4th Framework Program. Some Aspects of the methodology are at present being improved. This document applies to the computerised version 2.1 (VAZ01). (Author)

  13. Description of surface systems. Preliminary site description. Forsmark area Version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Lindborg, Tobias [ed.

    2005-06-01

    Swedish Nuclear Fuel and Waste Management Co (SKB) started site investigations for a deep repository for spent nuclear fuel in 2002 at two different sites in Sweden, Forsmark and Oskarshamn. The investigations should provide necessary information for a license application aimed at starting underground exploration. For this reason, ecosystem data need to be interpreted and assessed into site descriptive models, which in turn are used for safety assessment studies and for environmental impact assessment. Descriptions of the surface system are also needed for further planning of the site investigations. This report describes the surface ecosystems of the Forsmark site (e.g. hydrology, Quaternary deposits, chemistry, vegetation, animals and the human land use). The ecosystem description is an integration of the site and its regional setting, covering the current state of the biosphere as well as the ongoing natural processes affecting the longterm development. Improving the descriptions is important during both the initial and the complete site investigation phase. Before starting of the initial phase in Forsmark, version 0 of the site descriptive model was developed. The results of the initial site investigation phase is compiled into a preliminary site description of Forsmark (version 1.2) in June 2005. This report provides the major input and background to the biosphere description, in the 1.2 version of the Forsmark site description. The basis for this interim version is quality-assured field data from the Forsmark sub area and regional area, available in the SKB SICADA, and GIS data bases as of July 31th 2004 as well as version 1.1 of the Site Descriptive Model. To achieve an ecosystem site description there is a need to develop discipline-specific models by interpreting and analysing primary data. The different discipline-specific models are then integrated into a system describing interactions and flows and stocks of matter between and within functional units in

  14. Description of surface systems. Preliminary site description. Forsmark area Version 1.2

    International Nuclear Information System (INIS)

    Lindborg, Tobias

    2005-06-01

    Swedish Nuclear Fuel and Waste Management Co (SKB) started site investigations for a deep repository for spent nuclear fuel in 2002 at two different sites in Sweden, Forsmark and Oskarshamn. The investigations should provide necessary information for a license application aimed at starting underground exploration. For this reason, ecosystem data need to be interpreted and assessed into site descriptive models, which in turn are used for safety assessment studies and for environmental impact assessment. Descriptions of the surface system are also needed for further planning of the site investigations. This report describes the surface ecosystems of the Forsmark site (e.g. hydrology, Quaternary deposits, chemistry, vegetation, animals and the human land use). The ecosystem description is an integration of the site and its regional setting, covering the current state of the biosphere as well as the ongoing natural processes affecting the longterm development. Improving the descriptions is important during both the initial and the complete site investigation phase. Before starting of the initial phase in Forsmark, version 0 of the site descriptive model was developed. The results of the initial site investigation phase is compiled into a preliminary site description of Forsmark (version 1.2) in June 2005. This report provides the major input and background to the biosphere description, in the 1.2 version of the Forsmark site description. The basis for this interim version is quality-assured field data from the Forsmark sub area and regional area, available in the SKB SICADA, and GIS data bases as of July 31th 2004 as well as version 1.1 of the Site Descriptive Model. To achieve an ecosystem site description there is a need to develop discipline-specific models by interpreting and analysing primary data. The different discipline-specific models are then integrated into a system describing interactions and flows and stocks of matter between and within functional units in

  15. Motivation and Design of the Sirocco Storage System Version 1.0.

    Energy Technology Data Exchange (ETDEWEB)

    Curry, Matthew Leon [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ward, H. Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Danielson, Geoffrey Charles [Hewlett-Packard Company, Palo Alto, CA (United States)

    2015-07-01

    Sirocco is a massively parallel, high performance storage system for the exascale era. It emphasizes client-to-client coordination, low server-side coupling, and free data movement to improve resilience and performance. Its architecture is inspired by peer-to-peer and victim- cache architectures. By leveraging these ideas, Sirocco natively supports several media types, including RAM, flash, disk, and archival storage, with automatic migration between levels. Sirocco also includes storage interfaces and support that are more advanced than typical block storage. Sirocco enables clients to efficiently use key-value storage or block-based storage with the same interface. It also provides several levels of transactional data updates within a single storage command, including full ACID-compliant updates. This transaction support extends to updating several objects within a single transaction. Further support is provided for con- currency control, enabling greater performance for workloads while providing safe concurrent modification. By pioneering these and other technologies and techniques in the storage system, Sirocco is poised to fulfill a need for a massively scalable, write-optimized storage system for exascale systems. This is version 1.0 of a document reflecting the current and planned state of Sirocco. Further versions of this document will be accessible at http://www.cs.sandia.gov/Scalable_IO/ sirocco .

  16. Topoisomerase IB of Deinococcus radiodurans resolves guanine ...

    Indian Academy of Sciences (India)

    2015-11-28

    Nov 28, 2015 ... All the oligonucleotides men- tioned here were ... further reactions with DraTopoIB were carried out at 37°C ... of G4 DNA moves faster than unfolded and intermolecular .... for its action on intramolecular G4 DNA structure was.

  17. JANIS 4: An Improved Version of the NEA Java-based Nuclear Data Information System

    International Nuclear Information System (INIS)

    Soppera, N.; Bossant, M.; Dupont, E.

    2014-01-01

    JANIS is software developed to facilitate the visualization and manipulation of nuclear data, giving access to evaluated data libraries, and to the EXFOR and CINDA databases. It is stand-alone Java software, downloadable from the web and distributed on DVD. Used offline, the system also makes use of an internet connection to access the NEA Data Bank database. It is now also offered as a full web application, only requiring a browser. The features added in the latest version of the software and this new web interface are described

  18. The Contradictions of the Modern Version of Russian Federalism: Instability of the System

    Directory of Open Access Journals (Sweden)

    Сергей Олегович Алехнович

    2011-03-01

    Full Text Available In the article there considered contradictions of the modern version of the Russian federalism, as a political and politological problem. The authors made an attempt to present the problem of federalism at conceptually-analytical level as a certain ritual meaning of the certain form of a state system thereby its values substance becomes an object of analysis. Besides applied function of federalism it's necessary to see the process of its perception and acceptance by national multinational consciousness through a prism of stability of political process, political practice, actions of the state institutes of power, persons and leaders of the center and regions.

  19. TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib)†

    OpenAIRE

    Molinaro, Angelo; Tiosano, Dov; Takatani, Rieko; Chrysis, Dionisios; Russell, William; Koscielniak, Nikolas; Kottler, Marie-Laure; Agretti, Patrizia; De Marco, Giuseppina; Ahtiainen, Petteri; Christov, Marta; Mäkitie, Outi; Tonacchera, Massimo; Jüppner, Harald

    2015-01-01

    Hypocalcemia and hyperphosphatemia because of resistance towards parathyroid hormone (PTH) in the proximal renal tubules are the most prominent abnormalities in patients affected by pseudohypoparathyroidism type Ib (PHP-Ib). In this rare disorder that is caused by GNAS methylation changes, resistance can occur towards other hormones, such as thyroid-stimulating hormone (TSH), that mediate their actions through G protein-coupled receptors. However, these additional laboratory abnormalities are...

  20. ORACLS- OPTIMAL REGULATOR ALGORITHMS FOR THE CONTROL OF LINEAR SYSTEMS (DEC VAX VERSION)

    Science.gov (United States)

    Frisch, H.

    1994-01-01

    computations: the eigenvalues and eigenvectors of real matrices; the relative stability of a given matrix; matrix factorization; the solution of linear constant coefficient vector-matrix algebraic equations; the controllability properties of a linear time-invariant system; the steady-state covariance matrix of an open-loop stable system forced by white noise; and the transient response of continuous linear time-invariant systems. The control law design routines of ORACLS implement some of the more common techniques of time-invariant LQG methodology. For the finite-duration optimal linear regulator problem with noise-free measurements, continuous dynamics, and integral performance index, a routine is provided which implements the negative exponential method for finding both the transient and steady-state solutions to the matrix Riccati equation. For the discrete version of this problem, the method of backwards differencing is applied to find the solutions to the discrete Riccati equation. A routine is also included to solve the steady-state Riccati equation by the Newton algorithms described by Klein, for continuous problems, and by Hewer, for discrete problems. Another routine calculates the prefilter gain to eliminate control state cross-product terms in the quadratic performance index and the weighting matrices for the sampled data optimal linear regulator problem. For cases with measurement noise, duality theory and optimal regulator algorithms are used to calculate solutions to the continuous and discrete Kalman-Bucy filter problems. Finally, routines are included to implement the continuous and discrete forms of the explicit (model-in-the-system) and implicit (model-in-the-performance-index) model following theory. These routines generate linear control laws which cause the output of a dynamic time-invariant system to track the output of a prescribed model. In order to apply ORACLS, the user must write an executive (driver) program which inputs the problem coefficients

  1. ORACLS- OPTIMAL REGULATOR ALGORITHMS FOR THE CONTROL OF LINEAR SYSTEMS (CDC VERSION)

    Science.gov (United States)

    Armstrong, E. S.

    1994-01-01

    computations: the eigenvalues and eigenvectors of real matrices; the relative stability of a given matrix; matrix factorization; the solution of linear constant coefficient vector-matrix algebraic equations; the controllability properties of a linear time-invariant system; the steady-state covariance matrix of an open-loop stable system forced by white noise; and the transient response of continuous linear time-invariant systems. The control law design routines of ORACLS implement some of the more common techniques of time-invariant LQG methodology. For the finite-duration optimal linear regulator problem with noise-free measurements, continuous dynamics, and integral performance index, a routine is provided which implements the negative exponential method for finding both the transient and steady-state solutions to the matrix Riccati equation. For the discrete version of this problem, the method of backwards differencing is applied to find the solutions to the discrete Riccati equation. A routine is also included to solve the steady-state Riccati equation by the Newton algorithms described by Klein, for continuous problems, and by Hewer, for discrete problems. Another routine calculates the prefilter gain to eliminate control state cross-product terms in the quadratic performance index and the weighting matrices for the sampled data optimal linear regulator problem. For cases with measurement noise, duality theory and optimal regulator algorithms are used to calculate solutions to the continuous and discrete Kalman-Bucy filter problems. Finally, routines are included to implement the continuous and discrete forms of the explicit (model-in-the-system) and implicit (model-in-the-performance-index) model following theory. These routines generate linear control laws which cause the output of a dynamic time-invariant system to track the output of a prescribed model. In order to apply ORACLS, the user must write an executive (driver) program which inputs the problem coefficients

  2. The IB Diploma and UK University Degree Qualifications

    Science.gov (United States)

    Frank-Gemmill, Gerda

    2013-01-01

    In recent years the International Baccalaureate (IB) Diploma has become widely accepted as a university-entry qualification in the UK, but there has been little quantitative research into the achievements of IB students at degree level. This study investigates IB students from one selective independent school who entered UK universities between…

  3. Computer-Aided System Engineering and Analysis (CASE/A) Programmer's Manual, Version 5.0

    Science.gov (United States)

    Knox, J. C.

    1996-01-01

    The Computer Aided System Engineering and Analysis (CASE/A) Version 5.0 Programmer's Manual provides the programmer and user with information regarding the internal structure of the CASE/A 5.0 software system. CASE/A 5.0 is a trade study tool that provides modeling/simulation capabilities for analyzing environmental control and life support systems and active thermal control systems. CASE/A has been successfully used in studies such as the evaluation of carbon dioxide removal in the space station. CASE/A modeling provides a graphical and command-driven interface for the user. This interface allows the user to construct a model by placing equipment components in a graphical layout of the system hardware, then connect the components via flow streams and define their operating parameters. Once the equipment is placed, the simulation time and other control parameters can be set to run the simulation based on the model constructed. After completion of the simulation, graphical plots or text files can be obtained for evaluation of the simulation results over time. Additionally, users have the capability to control the simulation and extract information at various times in the simulation (e.g., control equipment operating parameters over the simulation time or extract plot data) by using "User Operations (OPS) Code." This OPS code is written in FORTRAN with a canned set of utility subroutines for performing common tasks. CASE/A version 5.0 software runs under the VAX VMS(Trademark) environment. It utilizes the Tektronics 4014(Trademark) graphics display system and the VTIOO(Trademark) text manipulation/display system.

  4. iB1350 no.3. Passive double confinement and SA population dose evaluation for the iB1350

    International Nuclear Information System (INIS)

    Sato, Takashi; Matsumoto, Keiji; Hosomi, Kenji; Iwasaki, Ryuji

    2017-01-01

    iB1350 stands for an innovative, intelligent and inexpensive BWR 1350. It is the first Generation III.7 reactor after the Fukushima Daiichi accident. The iB1350 uses the Mark W containment and the in-containment filtered venting system (IFVS). The Mark W containment is made of reinforced concrete and has double cylinder FP barriers. There are also IC/iPCCS pools, a fuel pool and a dryer separator (DS) pool on the top slab of the containment. These pools work as water seal for FP leakage through the top slab. Most FP such as CsI are scrubbed in the pools. The containment head is also submerged in the reactor well pool. The pool water works as shielding for radiation from the reactor core during normal operation and water seal for FP scrubbing during a severe accident. The base mat concrete is covered with the S/P and the core catcher that is also submerged with corium flooding water during an accident. Therefore, the Mark W containment has passive double confinement barriers for FP. Moreover, the IFVS works as in-containment filtered venting system that scrubs FP from the wet well (WW) and the dry well (DW). The filtered venting tank is arranged in the outer well (OW) of the Mark W containment. Even noble gases and organic iodine going through the filtered venting system are still confined inside the containment and never released directly to the environment. The IFVS uses the innovative passive containment cooling system (iPCCS) as the pre-stage heat removal system. The iPCCS has a normal open suction line from the WW. Therefore, FP are scrubbed in the S/P at first and then vented into the filtered venting tank. After the DW suction line of the iPCCS is opened all the steam is cooled and condensed in the heat exchanger. Most FP are trapped in the condensate and returned into the WW through the condensate return line of the iPCCS. Therefore, the Mark W containment has excellent FP double confinement barriers and the in-containment filtered venting system that enable

  5. La inmigración brasileña en Portugal y España: ¿sistema migratorio ibérico? (Brazilian immigration in Portugal and Spain: Iberian immigration system?

    Directory of Open Access Journals (Sweden)

    Padilla, Beatriz

    2010-06-01

    Full Text Available Resumen: El objetivo de este artículo es ofrecer un análisis comparativo de la migración brasileña en España y Portugal a través de su contextualización en la emigración brasileña internacional reciente, la descripción de las características básicas y de los principales perfiles de esta población y del estudio de las motivaciones de la emigración y de la elección del país de destino. El estudio se basa fundamentalmente en las investigaciones llevadas a cabo por las autoras en el contexto portugués, español y brasileño desde una perspectiva metodológica cualitativa. Los resultados de la investigación señalan la presencia de similitudes y divergencias en los dos contextos de recepción de la migración brasileña. Sin embargo, el predominio de los paralelismos nos lleva a sugerir la existencia de una migración brasileña ibérica.Abstract: The aim of this article is to carry out a comparative analysis of Brazilian migration to Spain and Portugal, by providing a contextualization within the recent Brazilian international emigration flows, and a description of its basic features and main profiles of the population; and by offering explanations about the motivations for migration and about the selection of the country of destination. The study is mainly based on qualitative research carried out by the authors in the Portuguese, Spanish and Brazilian contexts. Results highlight similarities and differences in both contexts of reception of Brazilian immigration, however the prevalence of parallelisms suggests the existence of an Iberian Brazilian migration system.

  6. US Army Weapon Systems Human-Computer Interface (WSHCI) style guide, Version 1

    Energy Technology Data Exchange (ETDEWEB)

    Avery, L.W.; O`Mara, P.A.; Shepard, A.P.

    1996-09-30

    A stated goal of the U.S. Army has been the standardization of the human computer interfaces (HCIS) of its system. Some of the tools being used to accomplish this standardization are HCI design guidelines and style guides. Currently, the Army is employing a number of style guides. While these style guides provide good guidance for the command, control, communications, computers, and intelligence (C4I) domain, they do not necessarily represent the more unique requirements of the Army`s real time and near-real time (RT/NRT) weapon systems. The Office of the Director of Information for Command, Control, Communications, and Computers (DISC4), in conjunction with the Weapon Systems Technical Architecture Working Group (WSTAWG), recognized this need as part of their activities to revise the Army Technical Architecture (ATA). To address this need, DISC4 tasked the Pacific Northwest National Laboratory (PNNL) to develop an Army weapon systems unique HCI style guide. This document, the U.S. Army Weapon Systems Human-Computer Interface (WSHCI) Style Guide, represents the first version of that style guide. The purpose of this document is to provide HCI design guidance for RT/NRT Army systems across the weapon systems domains of ground, aviation, missile, and soldier systems. Each domain should customize and extend this guidance by developing their domain-specific style guides, which will be used to guide the development of future systems within their domains.

  7. Randomised controlled trial of mesalazine in IBS.

    Science.gov (United States)

    Barbara, Giovanni; Cremon, Cesare; Annese, Vito; Basilisco, Guido; Bazzoli, Franco; Bellini, Massimo; Benedetti, Antonio; Benini, Luigi; Bossa, Fabrizio; Buldrini, Paola; Cicala, Michele; Cuomo, Rosario; Germanà, Bastianello; Molteni, Paola; Neri, Matteo; Rodi, Marcello; Saggioro, Alfredo; Scribano, Maria Lia; Vecchi, Maurizio; Zoli, Giorgio; Corinaldesi, Roberto; Stanghellini, Vincenzo

    2016-01-01

    Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating the efficacy and safety of mesalazine in patients with IBS. We conducted a phase 3, multicentre, tertiary setting, randomised, double-blind, placebo-controlled trial in patients with Rome III confirmed IBS. Patients were randomly assigned to either mesalazine, 800 mg, or placebo, three times daily for 12 weeks, and were followed for additional 12 weeks. The primary efficacy endpoint was satisfactory relief of abdominal pain/discomfort for at least half of the weeks of the treatment period. The key secondary endpoint was satisfactory relief of overall IBS symptoms. Supportive analyses were also performed classifying as responders patients with a percentage of affirmative answers of at least 75% or >75% of time. A total of 185 patients with IBS were enrolled from 21 centres. For the primary endpoint, the responder patients were 68.6% in the mesalazine group versus 67.4% in the placebo group (p=0.870; 95% CI -12.8 to 15.1). In explorative analyses, with the 75% rule or >75% rule, the percentage of responders was greater in the mesalazine group with a difference over placebo of 11.6% (p=0.115; 95% CI -2.7% to 26.0%) and 5.9% (p=0.404; 95% CI -7.8% to 19.4%), respectively, although these differences were not significant. For the key secondary endpoint, overall symptoms improved in the mesalazine group and reached a significant difference of 15.1% versus placebo (p=0.032; 95% CI 1.5% to 28.7%) with the >75% rule. Mesalazine treatment was not superior than placebo on the study primary endpoint. However, a subgroup of patients with IBS showed a sustained therapy response and benefits from a mesalazine therapy. ClincialTrials.gov number, NCT00626288. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  8. A new version of Scilab software package for the study of dynamical systems

    Science.gov (United States)

    Bordeianu, C. C.; Felea, D.; Beşliu, C.; Jipa, Al.; Grossu, I. V.

    2009-11-01

    This work presents a new version of a software package for the study of chaotic flows, maps and fractals [1]. The codes were written using Scilab, a software package for numerical computations providing a powerful open computing environment for engineering and scientific applications. It was found that Scilab provides various functions for ordinary differential equation solving, Fast Fourier Transform, autocorrelation, and excellent 2D and 3D graphical capabilities. The chaotic behaviors of the nonlinear dynamics systems were analyzed using phase-space maps, autocorrelation functions, power spectra, Lyapunov exponents and Kolmogorov-Sinai entropy. Various well-known examples are implemented, with the capability of the users inserting their own ODE or iterative equations. New version program summaryProgram title: Chaos v2.0 Catalogue identifier: AEAP_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEAP_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 1275 No. of bytes in distributed program, including test data, etc.: 7135 Distribution format: tar.gz Programming language: Scilab 5.1.1. Scilab 5.1.1 should be installed before running the program. Information about the installation can be found at scilab.org/howto/install/windows" xlink:type="simple">http://wiki.scilab.org/howto/install/windows. Computer: PC-compatible running Scilab on MS Windows or Linux Operating system: Windows XP, Linux RAM: below 150 Megabytes Classification: 6.2 Catalogue identifier of previous version: AEAP_v1_0 Journal reference of previous version: Comput. Phys. Comm. 178 (2008) 788 Does the new version supersede the previous version?: Yes Nature of problem: Any physical model containing linear or nonlinear ordinary differential equations (ODE). Solution method: Numerical solving of

  9. Modeling and control simulation of the China CLEAR-IB

    International Nuclear Information System (INIS)

    Yan, Shoujun; Wan, Jiashuang; Wang, Pengfei; Fang, Huawei; Sun, Changyi; Zhao, Fuyu

    2014-01-01

    Highlights: • A model for the reactor for CLEAR-IB was developed. • A PI controller was designed to control the power. • A control strategy was adopted to control the water enthalpy of air cooler. • Dynamic simulation of the whole system was performed. - Abstract: To investigate the dynamic and control characteristics of the plant, a model for the main components of the reactor and the most relevant interactions among them is developed. The system comprises of the primary system with lead bismuth eutectic (LBE) as the coolant, the secondary circuit with steam water mixture as the coolant and the associated air cooling system for an effective rejection of thermal power to the environment as a final heat sink. A Proportional-Integral (PI) controller is designed to keep the power following the set value as quickly as possible. To keep outlet coolant of air coolers and inlet coolant of HXs being saturated water, a control strategy based on a simultaneous feed-forward and feedback scheme has been adopted. Based on the developed model and control strategy, dynamic simulation of the whole system in the cases of step changes of external source and load is performed. The simulation results show that the proposed model is accurate enough to describe the dynamic behaviors of the plant in spite of its simplicity. It has also been demonstrated that the developed controllers for the CLEAR-IB can provide superior reactor control capabilities due to the efficiency of the control strategy adopted

  10. Incremental testing of the Community Multiscale Air Quality (CMAQ modeling system version 4.7

    Directory of Open Access Journals (Sweden)

    K. M. Foley

    2010-03-01

    Full Text Available This paper describes the scientific and structural updates to the latest release of the Community Multiscale Air Quality (CMAQ modeling system version 4.7 (v4.7 and points the reader to additional resources for further details. The model updates were evaluated relative to observations and results from previous model versions in a series of simulations conducted to incrementally assess the effect of each change. The focus of this paper is on five major scientific upgrades: (a updates to the heterogeneous N2O5 parameterization, (b improvement in the treatment of secondary organic aerosol (SOA, (c inclusion of dynamic mass transfer for coarse-mode aerosol, (d revisions to the cloud model, and (e new options for the calculation of photolysis rates. Incremental test simulations over the eastern United States during January and August 2006 are evaluated to assess the model response to each scientific improvement, providing explanations of differences in results between v4.7 and previously released CMAQ model versions. Particulate sulfate predictions are improved across all monitoring networks during both seasons due to cloud module updates. Numerous updates to the SOA module improve the simulation of seasonal variability and decrease the bias in organic carbon predictions at urban sites in the winter. Bias in the total mass of fine particulate matter (PM2.5 is dominated by overpredictions of unspeciated PM2.5 (PMother in the winter and by underpredictions of carbon in the summer. The CMAQv4.7 model results show slightly worse performance for ozone predictions. However, changes to the meteorological inputs are found to have a much greater impact on ozone predictions compared to changes to the CMAQ modules described here. Model updates had little effect on existing biases in wet deposition predictions.

  11. Supply Chain Management on IBS Implementation in Klang Valley Construction Industry: Challenges and Issues

    Science.gov (United States)

    Azrizal Fauzi, Mohd; Hasim, Sulaiman; Awang, Anizah; Ridzuan, Ahmad Ruslan Mohd; Nur Yunus, Juzailah

    2017-12-01

    Industrialized Building System (IBS) is a system where the components of the building are manufactured in a factory and it will be transported to the site to form the structures. The supply chain management (SCM) is a system where the delivery flows of the IBS products from manufacturers to the site. The aim of this research is to identify the major challenges and to analyze the issues on IBS implementation in SCM in Klang Valley from the manufacturers perspective. The methodology used in this paper is based on primary data through questionnaire and interview. Questionnaires were sent to the Manufacturers. It can be concluded that this paper attempts to present more on the challenges and issues that those companies of manufacturers faced during their success journey in finding integration in their supply chain. The main contributions of this paper are integrating all the supply chain integration challenges and issues on IBS. Therefore, these contributions will be helpful for the organization of manufacturers and IBS players that establish the integration in their SCM.

  12. Development of environmental dose assessment system (EDAS) code of PC version

    Energy Technology Data Exchange (ETDEWEB)

    Taki, Mitsumasa; Kikuchi, Masamitsu; Kobayashi, Hideo; Yamaguchi, Takenori [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-05-01

    A computer code (EDAS) was developed to assess the public dose for the safety assessment to get the license of nuclear reactor operation. This code system is used for the safety analysis of public around the nuclear reactor in normal operation and severe accident. This code was revised and composed for personal computer user according to the Nuclear Safety Guidelines reflected the ICRP1990 recommendation. These guidelines are revised by Nuclear Safety Commission on March, 2001, which are 'Weather analysis guideline for the safety assessment of nuclear power reactor', 'Public dose around the facility assessment guideline corresponding to the objective value for nuclear power light water reactor' and 'Public dose assessment guideline for safety review of nuclear power light water reactor'. This code has been already opened for public user by JAERI, and English version code and user manual are also prepared. This English version code is helpful for international cooperation concerning the nuclear safety assessment with JAERI. (author)

  13. Systems analysis programs for hands-on integrated reliability evaluations (SAPHIRE), Version 5.0

    International Nuclear Information System (INIS)

    Russell, K.D.; Kvarfordt, K.J.; Hoffman, C.L.

    1995-10-01

    The Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE) refers to a set of several microcomputer programs that were developed to create and analyze probabilistic risk assessments (PRAs), primarily for nuclear power plants. The Graphical Evaluation Module (GEM) is a special application tool designed for evaluation of operational occurrences using the Accident Sequence Precursor (ASP) program methods. GEM provides the capability for an analyst to quickly and easily perform conditional core damage probability (CCDP) calculations. The analyst can then use the CCDP calculations to determine if the occurrence of an initiating event or a condition adversely impacts safety. It uses models and data developed in the SAPHIRE specially for the ASP program. GEM requires more data than that normally provided in SAPHIRE and will not perform properly with other models or data bases. This is the first release of GEM and the developers of GEM welcome user comments and feedback that will generate ideas for improvements to future versions. GEM is designated as version 5.0 to track GEM codes along with the other SAPHIRE codes as the GEM relies on the same, shared database structure

  14. The GMAO Hybrid Ensemble-Variational Atmospheric Data Assimilation System: Version 2.0

    Science.gov (United States)

    Todling, Ricardo; El Akkraoui, Amal

    2018-01-01

    This document describes the implementation and usage of the Goddard Earth Observing System (GEOS) Hybrid Ensemble-Variational Atmospheric Data Assimilation System (Hybrid EVADAS). Its aim is to provide comprehensive guidance to users of GEOS ADAS interested in experimenting with its hybrid functionalities. The document is also aimed at providing a short summary of the state-of-science in this release of the hybrid system. As explained here, the ensemble data assimilation system (EnADAS) mechanism added to GEOS ADAS to enable hybrid data assimilation applications has been introduced to the pre-existing machinery of GEOS in the most non-intrusive possible way. Only very minor changes have been made to the original scripts controlling GEOS ADAS with the objective of facilitating its usage by both researchers and the GMAO's near-real-time Forward Processing applications. In a hybrid scenario two data assimilation systems run concurrently in a two-way feedback mode such that: the ensemble provides background ensemble perturbations required by the ADAS deterministic (typically high resolution) hybrid analysis; and the deterministic ADAS provides analysis information for recentering of the EnADAS analyses and information necessary to ensure that observation bias correction procedures are consistent between both the deterministic ADAS and the EnADAS. The nonintrusive approach to introducing hybrid capability to GEOS ADAS means, in particular, that previously existing features continue to be available. Thus, not only is this upgraded version of GEOS ADAS capable of supporting new applications such as Hybrid 3D-Var, 3D-EnVar, 4D-EnVar and Hybrid 4D-EnVar, it remains possible to use GEOS ADAS in its traditional 3D-Var mode which has been used in both MERRA and MERRA-2. Furthermore, as described in this document, GEOS ADAS also supports a configuration for exercising a purely ensemble-based assimilation strategy which can be fully decoupled from its variational component. We

  15. USES 2.0, The Uniform System for the Evaluation of Substances, version 2.0 ; supplement to EUSES

    NARCIS (Netherlands)

    Linders JBHJ; Jager DT; CSR; ECO

    1997-01-01

    This interim report describes the updated risk assessment system for agricultural and non-agricultural pesticides. It will be integrated with the European Union System for the Evaluation of Substances, EUSES 1.0, into USES 2.0, the second version of the Uniform System for the Evaluation of

  16. A Research on Development of The Multi-mode Flood Forecasting System Version Management

    Science.gov (United States)

    Shen, J.-C.; Chang, C. H.; Lien, H. C.; Wu, S. J.; Horng, M. J.

    2009-04-01

    With the global economy and technological development, the degree of urbanization and population density relative to raise. At the same time, a natural buffer space and resources year after year, the situation has been weakened, not only lead to potential environmental disasters, more and more serious, disaster caused by the economy, loss of natural environment at all levels has been expanded. In view of this, the active participation of all countries in the world cross-sectoral integration of disaster prevention technology research and development, in addition, the specialized field of disaster prevention technology, science and technology development, network integration technology, high-speed data transmission and information to support the establishment of mechanisms for disaster management The decision-making and cross-border global disaster information network building and other related technologies, has become the international anti-disaster science and technology development trends, this trend. Naturally a few years in Taiwan, people's lives and property losses caused by many problems related to natural disaster prevention and disaster prevention and the establishment of applications has become a very important. For FEWS_Taiwan, flood warning system developed by the Delft Hydraulics and introduced the Water Resources Agency (WRA), it provides those functionalities for users to modify contents to add the basins, regions, data sources, models and etc. Despite this advantage, version differences due to different users or different teams yet bring about the difficulties on synchronization and integration.At the same time in different research teams will also add different modes of meteorological and hydrological data. From the government perspective of WRA, the need to plan standard operation procedures for system integration demands that the effort for version control due to version differences must be cost down or yet canceled out. As for FEWS_Taiwan, this

  17. Overcoming ICT Barriers in IBS Management Process in Malaysia Construction Industry

    Directory of Open Access Journals (Sweden)

    Soon Ern Peniel Ang

    2017-01-01

    Full Text Available As the result of government’s initiative and future outlook in uprising the awareness towards the implementation of sustainable elements in construction industries, the Industrialized Building System (IBS is one of the approaches that had been introduced as an alternative to conventional building method and produce the new strategy of reducing the waste of materials in construction. The IBS approach is actively promoted through several strategies and incentives as an alternative to conventional building methods. Extensive uptakes of modern Information Communication Technology (ICT applications are able to support the different IBS processes for effective production. However, it is argued that ICT uptake at the organizational level needs to be regularly improved. Thus, this paper fulfills the need to identify the critical barriers to ICT employment and highlighting the ICT drivers in enhancing the IBS management process. Critical barriers and drivers to ICT uptake were identified through questionnaire survey with industry stakeholders and were analyzed using mean index and critical t-value with the use of SPSS software. The critical drivers are top management support and commitment and improving the availability of the technologies. The critical drivers which were identified are significant in ensuring the enhancement of ICT implementation. Hence, any system in place should avoid the highest ranked barriers or seek to alleviate their impact by focusing on the identified drivers in order to enhance implementation of ICT in IBS process management.

  18. Federal Emergency Management Information System (FEMIS) System Administration Guide for FEMIS Version 1.5

    Energy Technology Data Exchange (ETDEWEB)

    Bower, John C.(BATTELLE (PACIFIC NW LAB)); Burnett, Robert A.(BATTELLE (PACIFIC NW LAB)); Carter, Richard J.(BATTELLE (PACIFIC NW LAB)); Downing, Timothy R.(BATTELLE (PACIFIC NW LAB)); Homer, Brian J.(BATTELLE (PACIFIC NW LAB)); Holter, Nancy A.(BATTELLE (PACIFIC NW LAB)); Johnson, Daniel M.(BATTELLE (PACIFIC NW LAB)); Johnson, Ranata L.(BATTELLE (PACIFIC NW LAB)); Johnson, Sharon M.(BATTELLE (PACIFIC NW LAB)); Loveall, Robert M.(BATTELLE (PACIFIC NW LAB)); Ramos Jr., Juan (BATTELLE (PACIFIC NW LAB)); Schulze, Stacy A.(BATTELLE (PACIFIC NW LAB)); Sivaraman, Chitra (BATTELLE (PACIFIC NW LAB)); Stephan, Alex J.(BATTELLE (PACIFIC NW LAB)); Stoops, Lamar R.(BATTELLE (PACIFIC NW LAB)); Wood, Blanche M.(BATTELLE (PACIFIC NW LAB))

    2001-12-01

    The Federal Emergency Management System (FEMIS) is an emergency management planning and response tool. The FEMIS System Administration Guide provides information on FEMIS System Administrator activities as well as the utilities that are included with FEMIS.

  19. TADIR-production version: El-Op's high-resolution 480x4 TDI thermal imaging system

    Science.gov (United States)

    Sarusi, Gabby; Ziv, Natan; Zioni, O.; Gaber, J.; Shechterman, Mark S.; Lerner, M.

    1999-07-01

    Efforts invested at El-Op during the last four years have led to the development of TADIR - engineering model thermal imager, demonstrated in 1998, and eventually to the final production version of TADIR to be demonstrated in full operation during 1999. Both versions take advantage of the high resolution and high sensitivity obtained by the 480 X 4 TDI MCT detector as well as many more features implemented in the system to obtain a state of the art high- end thermal imager. The production version of TADIR uses a 480 X 6 TDI HgCdTe detector made by the SCD Israeli company. In this paper, we will present the main features of the production version of TADIR.

  20. Critical ICT-Inhibiting Factors on IBS Production Management Processes in the Malaysia Construction Industry

    Science.gov (United States)

    Ern, Peniel Ang Soon; Kasim, Narimah; Hamid, Zuhairi Abd; Chen, Goh Kai

    2017-10-01

    Industrialized Building System (IBS) is one of the approaches that had been introduced as an alternative to conventional building method where it becomes the new strategy of enhancing the sustainable construction in current industries while spearheading a huge advancement of benefits with green constructions into the existing industries. The IBS approach is actively promoted through several strategies and incentives as an alternative to conventional building methods. Extensive uptakes of modern Information Communication Technology (ICT) applications are able to support the different IBS processes for effective production. However, it is argued that ICT uptake at the organisational level is still in its infancy. This raises the importance to identify critical inhibitors which are inhibing the effective uptake of ICT in the IBS production management process. Critical inhibitors to ICT uptake were identified through questionnaire survey with the IBS industry stakeholders. The mean index and critical t-values are generated with the use of the quantitative tool, Statistical Package for Social Sciences (SPSS). The top ten priority ranked inhibitors reflect the Cost, People and Process elements to ICT uptake. High costs in acquiring the technologies and resistance to change were some main concerns from the findings.

  1. AUS98 - The 1998 version of the AUS modular neutronic code system

    International Nuclear Information System (INIS)

    Robinson, G.S.; Harrington, B.V.

    1998-07-01

    AUS is a neutronics code system which may be used for calculations of a wide range of fission reactors, fusion blankets and other neutron applications. The present version, AUS98, has a nuclear cross section library based on ENDF/B-VI and includes modules which provide for reactor lattice calculations, one-dimensional transport calculations, multi-dimensional diffusion calculations, cell and whole reactor burnup calculations, and flexible editing of results. Calculations of multi-region resonance shielding, coupled neutron and photon transport, energy deposition, fission product inventory and neutron diffusion are combined within the one code system. The major changes from the previous AUS publications are the inclusion of a cross-section library based on ENDF/B-VI, the addition of the MICBURN module for controlling whole reactor burnup calculations, and changes to the system as a consequence of moving from IBM main-frame computers to UNIX workstations This report gives details of all system aspects of AUS and all modules except the POW3D multi-dimensional diffusion module

  2. AUS98 - The 1998 version of the AUS modular neutronic code system

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, G.S.; Harrington, B.V

    1998-07-01

    AUS is a neutronics code system which may be used for calculations of a wide range of fission reactors, fusion blankets and other neutron applications. The present version, AUS98, has a nuclear cross section library based on ENDF/B-VI and includes modules which provide for reactor lattice calculations, one-dimensional transport calculations, multi-dimensional diffusion calculations, cell and whole reactor burnup calculations, and flexible editing of results. Calculations of multi-region resonance shielding, coupled neutron and photon transport, energy deposition, fission product inventory and neutron diffusion are combined within the one code system. The major changes from the previous AUS publications are the inclusion of a cross-section library based on ENDF/B-VI, the addition of the MICBURN module for controlling whole reactor burnup calculations, and changes to the system as a consequence of moving from IBM main-frame computers to UNIX workstations This report gives details of all system aspects of AUS and all modules except the POW3D multi-dimensional diffusion module refs., tabs.

  3. TEJAS - TELEROBOTICS/EVA JOINT ANALYSIS SYSTEM VERSION 1.0

    Science.gov (United States)

    Drews, M. L.

    1994-01-01

    The primary objective of space telerobotics as a research discipline is the augmentation and/or support of extravehicular activity (EVA) with telerobotic activity; this allows increased emplacement of on-orbit assets while providing for their "in situ" management. Development of the requisite telerobot work system requires a well-understood correspondence between EVA and telerobotics that to date has been only partially established. The Telerobotics/EVA Joint Analysis Systems (TEJAS) hypermedia information system uses object-oriented programming to bridge the gap between crew-EVA and telerobotics activities. TEJAS Version 1.0 contains twenty HyperCard stacks that use a visual, customizable interface of icon buttons, pop-up menus, and relational commands to store, link, and standardize related information about the primitives, technologies, tasks, assumptions, and open issues involved in space telerobot or crew EVA tasks. These stacks are meant to be interactive and can be used with any database system running on a Macintosh, including spreadsheets, relational databases, word-processed documents, and hypermedia utilities. The software provides a means for managing volumes of data and for communicating complex ideas, relationships, and processes inherent to task planning. The stack system contains 3MB of data and utilities to aid referencing, discussion, communication, and analysis within the EVA and telerobotics communities. The six baseline analysis stacks (EVATasks, EVAAssume, EVAIssues, TeleTasks, TeleAssume, and TeleIssues) work interactively to manage and relate basic information which you enter about the crew-EVA and telerobot tasks you wish to analyze in depth. Analysis stacks draw on information in the Reference stacks as part of a rapid point-and-click utility for building scripts of specific task primitives or for any EVA or telerobotics task. Any or all of these stacks can be completely incorporated within other hypermedia applications, or they can be

  4. Comparison of capability between two versions of reactor transient diagnosis expert system 'DISKET' programmed in different languages

    International Nuclear Information System (INIS)

    Yokobayashi, Masao; Yoshida, Kazuo

    1991-01-01

    An expert system DISKET has been developed at JAERI to apply knowledge engineering techniques to the transient diagnosis of nuclear power plant. The first version of DISKET programmed in UTILISP has been developed with the main-frame computer FACOM M-780 at JAERI. The LISP language is not suitable for on-line diagnostic systems because it is highly dependent on computer to be used and requires a large computer memory. The large mainframe computer is also not suitable because there are various restrictions as a multi-user computer system. The second version of DISKET for a practical use has been developed in FORTRAN to realize on-line real time diagnoses with limited computer resources. These two versions of DISKET with the same knowledge base have been compared in running capability, and it has been found that the LISP version of DISKET needs more than two times of memory and CPU time of FORTRAN version. From this result, it is shown that this approach is a practical one to develop expert systems for on-line real time diagnosis of transients with limited computer resources. (author)

  5. Neutron dosimetry system SAIPS: Manual for users and programmers (Version 87-02)

    International Nuclear Information System (INIS)

    Berzonis, M.A.; Bondars, Kh.Ya.; Niedritis, A.M.

    1988-07-01

    SAIPS is a system used for neutron dosimetry by foil activation, containing a package of programs and a data base of neutron activation cross-sections. A description is given of the SAIPS indexed procedures and users language, which are designed for producing input data for programs unfolding neutron spectra from reaction rate measurements, for carrying out calculations and processing and comparing the results obtained, for utilizing the additional capabilities of the system, and for setting up a working version of the system from the magnetic tapes used for distribution. A description is given of the logical structure of the data sets containing the libraries of neutron cross-section and a priori spectra and also the libraries of calculated spectra. The annexes give examples of SAIPS in use, of the contents of the a priori spectra and neutron cross-section libraries, and of the contents of the SAIPS distribution tapes. SAIPS contains programs in PL/1 (opt), FORTRAN IV(H) and ASSEMBLER. 25 refs

  6. A Preliminary Version of Heavy Ion Treatment Planning System at IMP

    International Nuclear Information System (INIS)

    Liu Xinguo; Dai Zhongying; Ye Fei; Wu Qingfeng; Li Ping; Li Qiang; Jin Xiaodong; Du Xiaogang; WangYangping; Dang Jianwu

    2010-01-01

    Based on the Heavy Ion Research Facility in Lanzhou (HIRFL/HIRFL-CSR), clinical trials of heavy ion radiotherapy are being conducted at the Institute of Modern Physics (IMP), Chinese Academy of Sciences, where two-dimensional(2D) layer-stacking conformal irradiation method in a passive beam delivery system was applied. To make better use of the biophysical advantages of heavy ion beams and ensure success of the clinical trials, a preliminary version of heavy ion treatment planning system (TPS) has been developed at IMP. The TPS was designed in a manner to adapt to the 2D layer-stacking conformal irradiation method. The architecture and function of the TPS software and the implementation of dose calculation algorithm in the TPS were introduced in this paper.The deviation between the doses planned by the TPS and measured through an anthropomorphous phantom was verified to be less than 5%. Finally,the pending issues for developing a sophisticated treatment planning system at IMP were discussed. (authors)

  7. Federal Emergency Management Information System (FEMIS) system administration guide. Version 1.3

    Energy Technology Data Exchange (ETDEWEB)

    Burford, M.J.; Burnett, R.A.; Downing, T.R. [and others

    1996-12-01

    The Federal Emergency Management Information System (FEMIS) is an emergency management planning and analysis tool that was developed by the (Pacific Northwest National Laboratory) (PNNL) under the direction of the U.S. Army Chemical Biological Defense Command. The FEMIS System Administration Guide defines FEMIS hardware and software requirements and gives instructions for installing the FEMIS software package. 91 This document also contains information on the following: software installation for the FEMIS data servers, communication server, mail server, and the emergency management workstations; distribution media loading and FEMIS installation validation and troubleshooting; and system management of FEMIS users, login, privileges, and usage. The system administration utilities (tools), available in the FEMIS client software, are described for user accounts and site profile. This document also describes the installation and use of system and database administration utilities that will assist in keeping the FEMIS system running in an operational environment.

  8. Omega version 2.2: Rule-based deterioration identification and management system. Final report

    International Nuclear Information System (INIS)

    Kataoka, S.; Kojima, T.; Pavinich, W.A.; Andrews, J.D.

    1996-06-01

    This report presents the Omega Version 2.2 (Ωs) rule-based computer program for identifying material deteriorations in the metallic structures, systems and components of LWR nuclear power units. The basis of Us is that understanding what material deteriorations might occur as a function of service life is fundamental to: (1) the development and optimization of preventive maintenance programs, (2) ensuring that current maintenance programs recognize applicable degradations, and (3) demonstrating the adequacy of deterioration management to safety regulatory authorities. The system was developed to assist utility engineers in determining which aging degradation mechanisms are acting on specific components. Direction is also provided to extend this system to manage deterioration and evaluate the efficacy of existing age-related degradation mitigation programs. This system can provide support for justification for continued operation and license renewal. It provides traceability to the data sources used in the logic development. A tiered approach is used to quickly isolate potential age-related degradation for components in a particular location. A potential degradation mechanism is then screened by additional rules to establish its plausibility. Ωs includes a user-friendly system interface and provides default environmental data and materials in the event they are unknown to the user. Ωs produces a report, with references, that validates the elimination of a degradation mechanism from further consideration or the determination that a specific degradation mechanism is acting on a specific material. This report also describes logic for identifying deterioration caused by intrusions and inspection-based deteriorations, along with future plans to program and integrate these features with Ωs

  9. Systems Biology Markup Language (SBML Level 2 Version 5: Structures and Facilities for Model Definitions

    Directory of Open Access Journals (Sweden)

    Hucka Michael

    2015-06-01

    Full Text Available Computational models can help researchers to interpret data, understand biological function, and make quantitative predictions. The Systems Biology Markup Language (SBML is a file format for representing computational models in a declarative form that can be exchanged between different software systems. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 5 of SBML Level 2. The specification defines the data structures prescribed by SBML as well as their encoding in XML, the eXtensible Markup Language. This specification also defines validation rules that determine the validity of an SBML document, and provides many examples of models in SBML form. Other materials and software are available from the SBML project web site, http://sbml.org/.

  10. Systems Biology Markup Language (SBML) Level 2 Version 5: Structures and Facilities for Model Definitions.

    Science.gov (United States)

    Hucka, Michael; Bergmann, Frank T; Dräger, Andreas; Hoops, Stefan; Keating, Sarah M; Le Novère, Nicolas; Myers, Chris J; Olivier, Brett G; Sahle, Sven; Schaff, James C; Smith, Lucian P; Waltemath, Dagmar; Wilkinson, Darren J

    2015-09-04

    Computational models can help researchers to interpret data, understand biological function, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that can be exchanged between different software systems. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 5 of SBML Level 2. The specification defines the data structures prescribed by SBML as well as their encoding in XML, the eXtensible Markup Language. This specification also defines validation rules that determine the validity of an SBML document, and provides many examples of models in SBML form. Other materials and software are available from the SBML project web site, http://sbml.org.

  11. The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 1 Core.

    Science.gov (United States)

    Hucka, Michael; Bergmann, Frank T; Hoops, Stefan; Keating, Sarah M; Sahle, Sven; Schaff, James C; Smith, Lucian P; Wilkinson, Darren J

    2015-09-04

    Computational models can help researchers to interpret data, understand biological function, and make quantitative predictions. The Systems Biology Markup Language (SBML) is a file format for representing computational models in a declarative form that can be exchanged between different software systems. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Version 1 of SBML Level 3 Core. The specification defines the data structures prescribed by SBML as well as their encoding in XML, the eXtensible Markup Language. This specification also defines validation rules that determine the validity of an SBML document, and provides many examples of models in SBML form. Other materials and software are available from the SBML project web site, http://sbml.org/.

  12. The Systems Biology Markup Language (SBML: Language Specification for Level 3 Version 1 Core

    Directory of Open Access Journals (Sweden)

    Hucka Michael

    2018-04-01

    Full Text Available Computational models can help researchers to interpret data, understand biological functions, and make quantitative predictions. The Systems Biology Markup Language (SBML is a file format for representing computational models in a declarative form that different software systems can exchange. SBML is oriented towards describing biological processes of the sort common in research on a number of topics, including metabolic pathways, cell signaling pathways, and many others. By supporting SBML as an input/output format, different tools can all operate on an identical representation of a model, removing opportunities for translation errors and assuring a common starting point for analyses and simulations. This document provides the specification for Release 2 of Version 1 of SBML Level 3 Core. The specification defines the data structures prescribed by SBML, their encoding in XML (the eXtensible Markup Language, validation rules that determine the validity of an SBML document, and examples of models in SBML form. No design changes have been made to the description of models between Release 1 and Release 2; changes are restricted to the format of annotations, the correction of errata and the addition of clarifications. Other materials and software are available from the SBML project website at http://sbml.org/.

  13. International safeguards data management system. System description: Version 1.1.; Release PLI 82

    International Nuclear Information System (INIS)

    Argentesi, T.; Casilli, T.; Costantini, L.; Dondi, M.G.; Franklin, M.

    1982-01-01

    This document describes a nuclear material accountancy system which has been developed using the ADABAS data base management system and is implemented on the JRC-Ispra computer. Throughout the report, the data base system is referred to as ''ISADAM'', i.e. International Safeguards Data Management System. The system provides tools for a safeguards authority to decide whether an operators MUF (Material Unaccounted For) can be accounted for as an accumulation of operator measurement errors. The principle objective of the applications programs described here is to provide a variance analysis of MUF in which the variance of MUF is computed as a function of the accounting declarations and the error characteristics of the operator measurement system. A overview of ISADAM is presented; then, a detailed description of the processing applied by the system is given. A description of the parameter information required by the four autonomous programs ISADAM is presented. In developing ISADAM, one of the prime factors taken into consideration was the ease with which it could be used

  14. Version pressure feedback mechanisms for speculative versioning caches

    Science.gov (United States)

    Eichenberger, Alexandre E.; Gara, Alan; O& #x27; Brien, Kathryn M.; Ohmacht, Martin; Zhuang, Xiaotong

    2013-03-12

    Mechanisms are provided for controlling version pressure on a speculative versioning cache. Raw version pressure data is collected based on one or more threads accessing cache lines of the speculative versioning cache. One or more statistical measures of version pressure are generated based on the collected raw version pressure data. A determination is made as to whether one or more modifications to an operation of a data processing system are to be performed based on the one or more statistical measures of version pressure, the one or more modifications affecting version pressure exerted on the speculative versioning cache. An operation of the data processing system is modified based on the one or more determined modifications, in response to a determination that one or more modifications to the operation of the data processing system are to be performed, to affect the version pressure exerted on the speculative versioning cache.

  15. TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib).

    Science.gov (United States)

    Molinaro, Angelo; Tiosano, Dov; Takatani, Rieko; Chrysis, Dionisios; Russell, William; Koscielniak, Nikolas; Kottler, Marie-Laure; Agretti, Patrizia; De Marco, Giuseppina; Ahtiainen, Petteri; Christov, Marta; Mäkitie, Outi; Tonacchera, Massimo; Jüppner, Harald

    2015-05-01

    Hypocalcemia and hyperphosphatemia because of resistance toward parathyroid hormone (PTH) in the proximal renal tubules are the most prominent abnormalities in patients affected by pseudohypoparathyroidism type Ib (PHP-Ib). In this rare disorder, which is caused by GNAS methylation changes, resistance can occur toward other hormones, such as thyroid-stimulating hormone (TSH), that mediate their actions through G protein-coupled receptors. However, these additional laboratory abnormalities are usually not recognized until PTH-resistant hypocalcemia becomes clinically apparent. We now describe four pediatric patients, first diagnosed with subclinical or overt hypothyroidism between the ages of 0.2 and 15 years, who developed overt PTH-resistance 3 to 20 years later. Although anti-thyroperoxidase (anti-TPO) antibodies provided a plausible explanation for hypothyroidism in one of these patients, this and two other patients revealed broad epigenetic GNAS abnormalities, which included loss of methylation (LOM) at exons AS, XL, and A/B, and gain of methylation at exon NESP55; ie, findings consistent with PHP-Ib. LOM at GNAS exon A/B alone led in the fourth patient to the identification of a maternally inherited 3-kb STX16 deletion, a well-established cause of autosomal dominant PHP-Ib. Although GNAS methylation changes were not detected in additional pediatric and adult patients with subclinical hypothyroidism (23 pediatric and 39 adult cases), hypothyroidism can obviously be the initial finding in PHP-Ib patients. One should therefore consider measuring PTH, along with calcium and phosphate, in patients with unexplained hypothyroidism for extended periods of time to avoid hypocalcemia and associated clinical complications. © 2014 American Society for Bone and Mineral Research.

  16. TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib)†

    Science.gov (United States)

    Molinaro, Angelo; Tiosano, Dov; Takatani, Rieko; Chrysis, Dionisios; Russell, William; Koscielniak, Nikolas; Kottler, Marie-Laure; Agretti, Patrizia; De Marco, Giuseppina; Ahtiainen, Petteri; Christov, Marta; Mäkitie, Outi; Tonacchera, Massimo; Jüppner, Harald

    2014-01-01

    Hypocalcemia and hyperphosphatemia because of resistance towards parathyroid hormone (PTH) in the proximal renal tubules are the most prominent abnormalities in patients affected by pseudohypoparathyroidism type Ib (PHP-Ib). In this rare disorder that is caused by GNAS methylation changes, resistance can occur towards other hormones, such as thyroid-stimulating hormone (TSH), that mediate their actions through G protein-coupled receptors. However, these additional laboratory abnormalities are usually not recognized until PTH-resistant hypocalcemia becomes clinically apparent. We now describe four pediatric patients, first diagnosed with subclinical or overt hypothyroidism between the ages of 0.2 and 15 years, who developed overt PTH-resistance 3-20 years later. Although anti-TPO antibodies provided a plausible explanation for hypothyroidism in one of these patients, this and two other patients revealed broad epigenetic GNAS abnormalities, which included loss of methylation (LOM) at exons AS, XL and A/B, and gain of methylation at exon NESP55, i.e. findings consistent with PHP-Ib. LOM at GNAS exon A/B alone led in the fourth patient to the identification of a maternally inherited 3-kb STX16 deletion, a well-established cause of autosomal dominant PHP-Ib. Although GNAS methylation changes were not detected in additional pediatric and adult patients with subclinical hypothyroidism (23 pediatric and 39 adult cases), hypothyroidism can obviously be the initial finding in PHP-Ib patients. One should therefore consider measuring PTH, along with calcium and phosphate, in patients with unexplained hypothyroidism for extended periods of time to avoid hypocalcemia and associated clinical complications. PMID:25403028

  17. Federal Emergency Management Information System (FEMIS) System Administration Guide for FEMIS Version 1.4.6

    Energy Technology Data Exchange (ETDEWEB)

    Arp, J.A.; Bower, J.C.; Burnett, R.A.; Carter, R.J.; Downing, T.R.; Fangman, P.M.; Gerhardstein, L.H.; Homer, B.J.; Johnson, D.M.; Johnson, R.L.; Johnson, S.M.; Loveall, R.M.; Martin, T.J.; Millard, W.D.; Schulze, S.A.; Stoops, L.R.; Tzemos, S.; Wood, B.M.

    1999-06-29

    The Federal Emergency Management Information System (FEMIS) is an emergency management planning and response tool that was developed by the Pacific Northwest National Laboratory (PNNL) under the direction of the U.S. Army Chemical Biological Defense Command. The FEMIS System Administration Guide provides information necessary for the system administrator to maintain the FEMIS system. The FEMIS system is designed for a single Chemical Stockpile Emergency Preparedness Program (CSEPP) site that has multiple Emergency Operations Centers (EOCs). Each EOC has personal computers (PCs) that emergency planners and operations personnel use to do their jobs. These PCs are corrected via a local area network (LAN) to servers that provide EOC-wide services. Each EOC is interconnected to other EOCs via a Wide Area Network (WAN). Thus, FEMIS is an integrated software product that resides on client/server computer architecture. The main body of FEMIS software, referred to as the FEMIS Application Software, resides on the PC client(s) and is directly accessible to emergency management personnel. The remainder of the FEMIS software, referred to as the FEMIS Support Software, resides on the UNIX server. The Support Software provides the communication data distribution and notification functionality necessary to operate FEMIS in a networked, client/server environment.

  18. Federal Emergency Management Information System (FEMIS) system administration guide, version 1.4.5

    Energy Technology Data Exchange (ETDEWEB)

    Arp, J.A.; Burnett, R.A.; Carter, R.J. [and others

    1998-06-26

    The Federal Emergency Management Information Systems (FEMIS) is an emergency management planning and response tool that was developed by the Pacific Northwest National Laboratory (PNNL) under the direction of the US Army Chemical Biological Defense Command. The FEMIS System Administration Guide provides information necessary for the system administrator to maintain the FEMIS system. The FEMIS system is designed for a single Chemical Stockpile Emergency Preparedness Program (CSEPP) site that has multiple Emergency Operations Centers (EOCs). Each EOC has personal computers (PCs) that emergency planners and operations personnel use to do their jobs. These PCs are connected via a local area network (LAN) to servers that provide EOC-wide services. Each EOC is interconnected to other EOCs via a Wide Area Network (WAN). Thus, FEMIS is an integrated software product that resides on client/server computer architecture. The main body of FEMIS software, referred to as the FEMIS Application Software, resides on the PC client(s) and is directly accessible to emergency management personnel. The remainder of the FEMIS software, referred to as the FEMIS Support Software, resides on the UNIX server. The Support Software provides the communication, data distribution, and notification functionality necessary to operate FEMIS in a networked, client/server environment. The UNIX server provides an Oracle relational database management system (RDBMS) services, ARC/INFO GIS (optional) capabilities, and basic file management services. PNNL developed utilities that reside on the server include the Notification Service, the Command Service that executes the evacuation model, and AutoRecovery. To operate FEMIS, the Application Software must have access to a site specific FEMIS emergency management database. Data that pertains to an individual EOC`s jurisdiction is stored on the EOC`s local server. Information that needs to be accessible to all EOCs is automatically distributed by the FEMIS

  19. Human leucocyte antigen class Ib molecules in pregnancy success and early pregnancy loss

    DEFF Research Database (Denmark)

    Dahl, Mette; Hviid, Thomas Vauvert F

    2013-01-01

    AND CONCLUSIONS The HLA class Ib molecules seem to induce suppression of the maternal immune system, but are not necessarily fundamental factors for pregnancy success. However, evidence points towards low expression of these proteins, especially HLA-G, being associated with reduced fertility. To clarify...

  20. Complex Adaptive System of Systems (CASoS) Engineering Applications. Version 1.0.

    Energy Technology Data Exchange (ETDEWEB)

    Linebarger, John Michael; Maffitt, S. Louise (New Mexico Institute of Mining and Technology, Albuquerque, NM); Glass, Robert John, Jr.; Beyeler, Walter Eugene; Brown, Theresa Jean; Ames, Arlo Leroy

    2011-10-01

    Complex Adaptive Systems of Systems, or CASoS, are vastly complex eco-socio-economic-technical systems which we must understand to design a secure future for the nation and the world. Perturbations/disruptions in CASoS have the potential for far-reaching effects due to highly-saturated interdependencies and allied vulnerabilities to cascades in associated systems. The Phoenix initiative approaches this high-impact problem space as engineers, devising interventions (problem solutions) that influence CASoS to achieve specific aspirations. CASoS embody the world's biggest problems and greatest opportunities: applications to real world problems are the driving force of our effort. We are developing engineering theory and practice together to create a discipline that is grounded in reality, extends our understanding of how CASoS behave, and allows us to better control those behaviors. Through application to real-world problems, Phoenix is evolving CASoS Engineering principles while growing a community of practice and the CASoS engineers to populate it.

  1. Phoenix : Complex Adaptive System of Systems (CASoS) engineering version 1.0.

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Thomas W.; Quach, Tu-Thach; Detry, Richard Joseph; Conrad, Stephen Hamilton; Kelic, Andjelka; Starks, Shirley J.; Beyeler, Walter Eugene; Brodsky, Nancy S.; Verzi, Stephen J.; Brown, Theresa Jean; Glass, Robert John, Jr.; Sunderland, Daniel J.; Mitchell, Michael David; Ames, Arlo Leroy; Maffitt, S. Louise; Finley, Patrick D.; Russell, Eric Dean; Zagonel, Aldo A.; Reedy, Geoffrey E.; Mitchell, Roger A.; Corbet, Thomas Frank, Jr.; Linebarger, John Michael

    2011-08-01

    Complex Adaptive Systems of Systems, or CASoS, are vastly complex ecological, sociological, economic and/or technical systems which we must understand to design a secure future for the nation and the world. Perturbations/disruptions in CASoS have the potential for far-reaching effects due to pervasive interdependencies and attendant vulnerabilities to cascades in associated systems. Phoenix was initiated to address this high-impact problem space as engineers. Our overarching goals are maximizing security, maximizing health, and minimizing risk. We design interventions, or problem solutions, that influence CASoS to achieve specific aspirations. Through application to real-world problems, Phoenix is evolving the principles and discipline of CASoS Engineering while growing a community of practice and the CASoS engineers to populate it. Both grounded in reality and working to extend our understanding and control of that reality, Phoenix is at the same time a solution within a CASoS and a CASoS itself.

  2. The reliability, validity and responsiveness of the Thai version of Systemic Lupus Erythematosus Quality of Life (SLEQOL-TH) instrument.

    Science.gov (United States)

    Kasitanon, N; Wangkaew, S; Puntana, S; Sukitawut, W; Leong, K P; Louthrenoo, W

    2013-03-01

    The English version of the Systemic Lupus Erythematosus Quality of Life Questionnaire (SLEQOL) is a validated disease-specific quality of life instrument. The aim of this study was to evaluate the psychometric properties of the Thai version of the SLEQOL (SLEQOL-TH). Two independent translators translated the SLEQOL into Thai. The back translation of this version was performed by two other independent translators. The final version, SLEQOL-TH, was completed after resolving the discrepancies revealed by the back translation. One hundred and nine patients with SLE were enrolled to test the reliability, construct validity, floor and ceiling effects, and sensitivity to the changes of the SLEQOL-TH at six months. The differential item functioning (DIF) between the Thai and English versions was analyzed using the partial gamma. The internal consistency of the SLEQOL-TH was satisfactory with the overall Cronbach's alpha of 0.86. The test-retest reliability of the SLEQOL-TH was acceptable with the intra-class correlation coefficient of 0.86. Low correlations between the SLEQOL-TH and SLEDAI were observed. The total score of the SLEQOL-TH was moderately responsive to changes in quality of life, with a standardized response mean of 0.50. When comparing the SLEQOL-TH from Thai SLE patients with the original SLEQOL version obtained from Singapore SLE patients, 11 out of 40 items showed a moderate to large DIF. The SLEQOL-TH has acceptable psychometric properties and shows construct validity. In comparison with the English version of SLEQOL, there are some items that showed DIF. The applicability of the SLEQOL-TH in real-life clinical practice and clinical trials needs to be determined.

  3. USES 2.0, The Uniform System for the Evaluation of Substances, version 2.0 ; supplement to EUSES

    OpenAIRE

    Linders JBHJ; Jager DT (eds.); CSR; ECO

    1997-01-01

    This interim report describes the updated risk assessment system for agricultural and non-agricultural pesticides. It will be integrated with the European Union System for the Evaluation of Substances, EUSES 1.0, into USES 2.0, the second version of the Uniform System for the Evaluation of Substances. The report is primarily made as preparation to the programming and testing of USES 2.0.

  4. Evaluation of energy fluxes in the NCEP climate forecast system version 2.0 (CFSv2)

    Science.gov (United States)

    Rai, Archana; Saha, Subodh Kumar

    2018-01-01

    The energy fluxes at the surface and top of the atmosphere (TOA) from a long free run by the NCEP climate forecast system version 2.0 (CFSv2) are validated against several observation and reanalysis datasets. This study focuses on the annual mean energy fluxes and tries to link it with the systematic cold biases in the 2 m air temperature, particularly over the land regions. The imbalance in the long term mean global averaged energy fluxes are also evaluated. The global averaged imbalance at the surface and at the TOA is found to be 0.37 and 6.43 Wm-2, respectively. It is shown that CFSv2 overestimates the land surface albedo, particularly over the snow region, which in turn contributes to the cold biases in 2 m air temperature. On the other hand, surface albedo is highly underestimated over the coastal region around Antarctica and that may have contributed to the warm bias over that oceanic region. This study highlights the need for improvements in the parameterization of snow/sea-ice albedo scheme for a realistic simulation of surface temperature and that may have implications on the global energy imbalance in the model.

  5. The Systems Biology Markup Language (SBML) Level 3 Package: Layout, Version 1 Core.

    Science.gov (United States)

    Gauges, Ralph; Rost, Ursula; Sahle, Sven; Wengler, Katja; Bergmann, Frank Thomas

    2015-09-04

    Many software tools provide facilities for depicting reaction network diagrams in a visual form. Two aspects of such a visual diagram can be distinguished: the layout (i.e.: the positioning and connections) of the elements in the diagram, and the graphical form of the elements (for example, the glyphs used for symbols, the properties of the lines connecting them, and so on). For software tools that also read and write models in SBML (Systems Biology Markup Language) format, a common need is to store the network diagram together with the SBML representation of the model. This in turn raises the question of how to encode the layout and the rendering of these diagrams. The SBML Level 3 Version 1 Core specification does not provide a mechanism for explicitly encoding diagrams, but it does provide a mechanism for SBML packages to extend the Core specification and add additional syntactical constructs. The Layout package for SBML Level 3 adds the necessary features to SBML so that diagram layouts can be encoded in SBML files, and a companion package called SBML Rendering specifies how the graphical rendering of elements can be encoded. The SBML Layout package is based on the principle that reaction network diagrams should be described as representations of entities such as species and reactions (with direct links to the underlying SBML elements), and not as arbitrary drawings or graphs; for this reason, existing languages for the description of vector drawings (such as SVG) or general graphs (such as GraphML) cannot be used.

  6. The Systems Biology Markup Language (SBML Level 3 Package: Layout, Version 1 Core

    Directory of Open Access Journals (Sweden)

    Gauges Ralph

    2015-06-01

    Full Text Available Many software tools provide facilities for depicting reaction network diagrams in a visual form. Two aspects of such a visual diagram can be distinguished: the layout (i.e.: the positioning and connections of the elements in the diagram, and the graphical form of the elements (for example, the glyphs used for symbols, the properties of the lines connecting them, and so on. For software tools that also read and write models in SBML (Systems Biology Markup Language format, a common need is to store the network diagram together with the SBML representation of the model. This in turn raises the question of how to encode the layout and the rendering of these diagrams. The SBML Level 3 Version 1 Core specification does not provide a mechanism for explicitly encoding diagrams, but it does provide a mechanism for SBML packages to extend the Core specification and add additional syntactical constructs. The Layout package for SBML Level 3 adds the necessary features to SBML so that diagram layouts can be encoded in SBML files, and a companion package called SBML Rendering specifies how the graphical rendering of elements can be encoded.

  7. USER'S GUIDE TO THE PERSONAL COMPUTER VERSION OF THE BIOGENIC EMISSIONS INVENTORY SYSTEM (PC-BEIS2)

    Science.gov (United States)

    The document is a user's guide for an updated Personal Computer version of the Biogenic Emissions Inventory System (PC-BEIS2), allowing users to estimate hourly emissions of biogenic volatile organic compounds (BVOCs) and soil nitrogen oxide emissions for any county in the contig...

  8. Application of a general purpose user's version of the EGS4 code system to a photon skyshine benchmarking calculation

    International Nuclear Information System (INIS)

    Nojiri, I.; Fukasaku, Y.; Narita, O.

    1994-01-01

    A general purpose user's version of the EGS4 code system has been developed to make EGS4 easily applicable to the safety analysis of nuclear fuel cycle facilities. One such application involves the determination of skyshine dose for a variety of photon sources. To verify the accuracy of the code, it was benchmarked with Kansas State University (KSU) photon skyshine experiment of 1977. The results of the simulation showed that this version of EGS4 would be appicable to the skyshine calculation. (author)

  9. New technical functions for WSPEEDI: Worldwide version of System for Prediction of Environmental Emergency Dose Information

    International Nuclear Information System (INIS)

    Chino, Masamichi; Nagai, Haruyasu; Furuno, Akiko; Kitabata, Hideyuki; Yamazawa, Hiromi

    2000-01-01

    The Worldwide version of System for Prediction of Environmental Emergency Dose Information (WSPEEDI) at Japan Atomic Energy Research Institute (JAERI) is a computer-based system for providing real-time, world-wide, assessment of radiological impact due to nuclear emergencies. Since JAERI started the developpement of the system in 1980, various components of the system, e.g., three-dimensional atmospheric models, databases, data acquisition network, graphics, etc., have been integrated. The objective area has been also extended from local area for domestic nuclear incidents to hemispheric area for foreign ones. Furthermore, through the validation, exercises and responses to real events during the last decade, the following three state-of-the-art functions are under construction. (1) Construction of prototype international data communications network: For quick exchange of atmospheric modeling products and environmental data during emergency among world-wide emergency response systems, JAERI and Lawrence Livermore National Laboratory started a prototype information exchange protocol between WSPEEDI and the Atmospheric Release Advisory Capability ARAC. The network consists of the Web site/browser portion and the video-teleconferencing tool. The network has been utilized for a fire accident at bituminization plant for radioactive wastes of the former Power Reactor and Nuclear Fuel Development Corporation in March, 1997 and Argeciras incident in Spain occurred in May, 1998. (2) Development of synoptic hydrodynamic model: At present, WSPEEDI simply parameterizes the turbulence diffusion and precipitation scavenging, because information on the boundary layer, cloud and precipitation is insufficient in available global forecasts. Thus, to provide WSPEEDI with such information, this study aims to introduce a hydrodynamic model into WSPEEDI, which can predict boundary layer processes and moist processes, e.g., cloud formation and precipitation processes. (3) Development of

  10. Streptococcus sanguinis Class Ib Ribonucleotide Reductase

    Science.gov (United States)

    Makhlynets, Olga; Boal, Amie K.; Rhodes, DeLacy V.; Kitten, Todd; Rosenzweig, Amy C.; Stubbe, JoAnne

    2014-01-01

    Streptococcus sanguinis is a causative agent of infective endocarditis. Deletion of SsaB, a manganese transporter, drastically reduces S. sanguinis virulence. Many pathogenic organisms require class Ib ribonucleotide reductase (RNR) to catalyze the conversion of nucleotides to deoxynucleotides under aerobic conditions, and recent studies demonstrate that this enzyme uses a dimanganese-tyrosyl radical (MnIII2-Y•) cofactor in vivo. The proteins required for S. sanguinis ribonucleotide reduction (NrdE and NrdF, α and β subunits of RNR; NrdH and TrxR, a glutaredoxin-like thioredoxin and a thioredoxin reductase; and NrdI, a flavodoxin essential for assembly of the RNR metallo-cofactor) have been identified and characterized. Apo-NrdF with FeII and O2 can self-assemble a diferric-tyrosyl radical (FeIII2-Y•) cofactor (1.2 Y•/β2) and with the help of NrdI can assemble a MnIII2-Y• cofactor (0.9 Y•/β2). The activity of RNR with its endogenous reductants, NrdH and TrxR, is 5,000 and 1,500 units/mg for the Mn- and Fe-NrdFs (Fe-loaded NrdF), respectively. X-ray structures of S. sanguinis NrdIox and MnII2-NrdF are reported and provide a possible rationale for the weak affinity (2.9 μm) between them. These streptococcal proteins form a structurally distinct subclass relative to other Ib proteins with unique features likely important in cluster assembly, including a long and negatively charged loop near the NrdI flavin and a bulky residue (Thr) at a constriction in the oxidant channel to the NrdI interface. These studies set the stage for identifying the active form of S. sanguinis class Ib RNR in an animal model for infective endocarditis and establishing whether the manganese requirement for pathogenesis is associated with RNR. PMID:24381172

  11. Environmental Molecular Sciences Laboratory Operations System: Version 4.0 - system requirements specification

    Energy Technology Data Exchange (ETDEWEB)

    Kashporenko, D.

    1996-07-01

    This document is intended to provide an operations standard for the Environmental Molecular Sciences Laboratory OPerations System (EMSL OPS). It is directed toward three primary audiences: (1) Environmental Molecular Sciences Laboratory (EMSL) facility and operations personnel; (2) laboratory line managers and staff; and (3) researchers, equipment operators, and laboratory users. It is also a statement of system requirements for software developers of EMSL OPS. The need for a finely tuned, superior research environment as provided by the US Department of Energy`s (DOE) Environmental Molecular Sciences Laboratory has never been greater. The abrupt end of the Cold War and the realignment of national priorities caused major US and competing overseas laboratories to reposition themselves in a highly competitive research marketplace. For a new laboratory such as the EMSL, this means coming into existence in a rapidly changing external environment. For any major laboratory, these changes create funding uncertainties and increasing global competition along with concomitant demands for higher standards of research product quality and innovation. While more laboratories are chasing fewer funding dollars, research ideas and proposals, especially for molecular-level research in the materials and biological sciences, are burgeoning. In such an economically constrained atmosphere, reduced costs, improved productivity, and strategic research project portfolio building become essential to establish and maintain any distinct competitive advantage. For EMSL, this environment and these demands require clear operational objectives, specific goals, and a well-crafted strategy. Specific goals will evolve and change with the evolution of the nature and definition of DOE`s environmental research needs. Hence, EMSL OPS is designed to facilitate migration of these changes with ease into every pertinent job function, creating a facile {open_quotes}learning organization.{close_quotes}

  12. Clinical and Microbiological Effect of a Multispecies Probiotic Supplementation in Celiac Patients With Persistent IBS-type Symptoms: A Randomized, Double-Blind, Placebo-controlled, Multicenter Trial.

    Science.gov (United States)

    Francavilla, Ruggiero; Piccolo, Maria; Francavilla, Antonio; Polimeno, Lorenzo; Semeraro, Francesco; Cristofori, Fernanda; Castellaneta, Stefania; Barone, Michele; Indrio, Flavia; Gobbetti, Marco; De Angelis, Maria

    2018-04-23

    The goals of this study were to evaluate the efficacy and safety of a probiotic mixture in patients with celiac disease (CD) with irritable bowel syndrome (IBS)-type symptoms despite a strict gluten-free diet (GFD). About 30% of patients with CD adherent to a GFD suffer from IBS-type symptoms; a possible cause resides in the imbalances of the intestinal microbiota in CD. Probiotics may represent a potential treatment. CD patients with IBS-type symptoms entered a prospective, double-blind, randomized placebo-controlled study. A 6-week treatment period was preceded by a 2-week run-in and followed by a 6-week follow-up phase. Clinical data were monitored throughout the study by validated questionnaires: IBS Severity Scoring System (IBS-SSS); Gastrointestinal Symptom Rating Scale (GSRS); Bristol Stool Form Scale (BSFS); and IBS Quality of Life Questionnaire (IBS-QOL). The fecal microbiota were assayed using plate counts and 16S rRNA gene-based analysis. In total, 109 patients were randomized to probiotics (n=54) or placebo (n=55). IBS-SSS and GSRS decreased significantly in probiotics, as compared with placebo [(-15.9%±14.8% vs. 8.2%±25.9%; Psymptoms, in CD patients on strict GFD, and is associated with a modification of gut microbiota, characterized by an increase of bifidobacteria.

  13. Treatment of cancer of cervix stages IB1 and IB2 in the Hospital Calderon Guardia (2000-2003)

    International Nuclear Information System (INIS)

    Saenz, Oscar; Picans, Serafin

    2004-01-01

    The types of treatment applied in patients with stages of cancer of cervix IB1 and IB2, your evolution and prognosis were determined. Different methods of treatment were compared. It was a prospective descriptive and observational study of the patients of Servicio de Ginecologia Oncologica of the Hospital Calderon Guardia, San Jose, Costa Rica. It was carried out from August 2000 to November 2002. The study included all female patients with proved histological diagnosis of cervical cancer IB1 and IB2. All of them had pre-operative studies: plate of thorax, abdomen ultrasound, computerized axial tomography of pelvis and abdomen, at least received primary treatment (surgery) and the following monitoring. The statistical analysis was realized with chi-square evidences, through epi-info software. Of 24 patients only 19 got complete information. It was found a 22% of patients with positives adenopatias to level of histological study with a ganglionic compromise of 32% in general form, a 36% in the stages IB1 and a 25% in stages IB2. Of all the patients that presented ganglionic metastasis illness, did not get to show with the computerized axial tomography and it is concluded that TAC is a bad method for detection of the microscopic metastasis illness, or at least to 2 cm. None of the patients in stages IB1 presented relapse data in the observed period, founding a 100% of survival to 24 months. The patients in stages IB2 presented relapses, with a 75% of survival [es

  14. Comparing the standard EQ-5D three-level system with a five-level version

    NARCIS (Netherlands)

    Janssen, Mathieu F.; Birnie, Erwin; Haagsma, Juanita A.; Bonsel, Gouke J.

    2008-01-01

    OBJECTIVES: The aim of this study is a head-to-head comparison of the performance of the three-level EQ-5D (3L) and a newly developed five-level version (5L). METHODS: Eighty-two respondents valued 15 standardized disease descriptions and their own health on three response scales (3L, 5L, and visual

  15. MOST PROBABLE NUMBER (MPN) CALCULATOR Version 2.0 User and System Installation and Administration Manual

    Science.gov (United States)

    The new MPN Calculator is an easy-to-use stand alone Windows application built by Avineon, Inc. for the EPA. The calculator was built using Microsoft .NET (dot NET) version 3.5 SP1 (C#) and Windows Presentation Foundation technologies. The new calculator not only combines the mai...

  16. Weighted Domain Transfer Extreme Learning Machine and Its Online Version for Gas Sensor Drift Compensation in E-Nose Systems

    Directory of Open Access Journals (Sweden)

    Zhiyuan Ma

    2018-01-01

    Full Text Available Machine learning approaches have been widely used to tackle the problem of sensor array drift in E-Nose systems. However, labeled data are rare in practice, which makes supervised learning methods hard to be applied. Meanwhile, current solutions require updating the analytical model in an offline manner, which hampers their uses for online scenarios. In this paper, we extended Target Domain Adaptation Extreme Learning Machine (DAELM_T to achieve high accuracy with less labeled samples by proposing a Weighted Domain Transfer Extreme Learning Machine, which uses clustering information as prior knowledge to help select proper labeled samples and calculate sensitive matrix for weighted learning. Furthermore, we converted DAELM_T and the proposed method into their online learning versions under which scenario the labeled data are selected beforehand. Experimental results show that, for batch learning version, the proposed method uses around 20% less labeled samples while achieving approximately equivalent or better accuracy. As for the online versions, the methods maintain almost the same accuracies as their offline counterparts do, but the time cost remains around a constant value while that of offline versions grows with the number of samples.

  17. Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE), Version 5.0: Integrated Reliability and Risk Analysis System (IRRAS) reference manual. Volume 2

    International Nuclear Information System (INIS)

    Russell, K.D.; Kvarfordt, K.J.; Skinner, N.L.; Wood, S.T.; Rasmuson, D.M.

    1994-07-01

    The Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE) refers to a set of several microcomputer programs that were developed to create and analyze probabilistic risk assessments (PRAs), primarily for nuclear power plants. The Integrated Reliability and Risk Analysis System (IRRAS) is a state-of-the-art, microcomputer-based probabilistic risk assessment (PRA) model development and analysis tool to address key nuclear plant safety issues. IRRAS is an integrated software tool that gives the use the ability to create and analyze fault trees and accident sequences using a microcomputer. This program provides functions that range from graphical fault tree construction to cut set generation and quantification to report generation. Version 1.0 of the IRRAS program was released in February of 1987. Since then, many user comments and enhancements have been incorporated into the program providing a much more powerful and user-friendly system. This version has been designated IRRAS 5.0 and is the subject of this Reference Manual. Version 5.0 of IRRAS provides the same capabilities as earlier versions and ads the ability to perform location transformations, seismic analysis, and provides enhancements to the user interface as well as improved algorithm performance. Additionally, version 5.0 contains new alphanumeric fault tree and event used for event tree rules, recovery rules, and end state partitioning

  18. Invasive cervical carcinoma (Stages IB-IIB)

    International Nuclear Information System (INIS)

    Sironi, S.; Zanello, A.; Rodighiero, M.G.; Vanzulli, A.; Del Maschio, A.; Taccagni, G.L.; Belloni, C.

    1991-01-01

    In the patients with invasive cervical carcinoma, the accurate assessment of parametrial invasion greatly affects the therapeutic choice between surgery and radiation therapy. As a matter of fact, surgery is usually performed only in the patients with carcinoma confined to the cervix, whereas those with parametrial involvement, or more advanced stages, are treated with radiation therapy. This prospective study was aimed at investigating the comparative adequecy of CT and MR imaging in assessing parametrial status in the patients with invasive cervical cancer. Twenty-one consecutive patients, with histologic diagnosis of cervical carcinoma, were investigated. All of them were clinically considered as having invasive cervical cancer (FIGO stage IB-IIB) and subsequently underwent surgery. In all cases, detailed histology of the parametrium was obtained. Pathological data were compared with CT and MR findings in all cases. As for assessing parametrial involvement by cancer, CT had 62% accuracy, 63% sensitivity, and 60% specificity, versus MR imaging 81% accuracy, 69% sensitivity, and 80% specificify. Therefore, MR imaging appears to be superior to CT in assessing the parametrial status of patients with invasive cervical carcinoma; the method yields valuable information for treatment planning

  19. The Communication Function Classification System: cultural adaptation, validity, and reliability of the Farsi version for patients with cerebral palsy.

    Science.gov (United States)

    Soleymani, Zahra; Joveini, Ghodsiye; Baghestani, Ahmad Reza

    2015-03-01

    This study developed a Farsi language Communication Function Classification System and then tested its reliability and validity. Communication Function Classification System is designed to classify the communication functions of individuals with cerebral palsy. Up until now, there has been no instrument for assessment of this communication function in Iran. The English Communication Function Classification System was translated into Farsi and cross-culturally modified by a panel of experts. Professionals and parents then assessed the content validity of the modified version. A backtranslation of the Farsi version was confirmed by the developer of the English Communication Function Classification System. Face validity was assessed by therapists and parents of 10 patients. The Farsi Communication Function Classification System was administered to 152 individuals with cerebral palsy (age, 2 to 18 years; median age, 10 years; mean age, 9.9 years; standard deviation, 4.3 years). Inter-rater reliability was analyzed between parents, occupational therapists, and speech and language pathologists. The test-retest reliability was assessed for 75 patients with a 14 day interval between tests. The inter-rater reliability of the Communication Function Classification System was 0.81 between speech and language pathologists and occupational therapists, 0.74 between parents and occupational therapists, and 0.88 between parents and speech and language pathologists. The test-retest reliability was 0.96 for occupational therapists, 0.98 for speech and language pathologists, and 0.94 for parents. The findings suggest that the Farsi version of Communication Function Classification System is a reliable and valid measure that can be used in clinical settings to assess communication function in patients with cerebral palsy. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Crosscultural Adaptation and Validation of the Korean Version of the New Knee Society Knee Scoring System.

    Science.gov (United States)

    Kim, Seok Jin; Basur, Mohnish Singh; Park, Chang Kyu; Chong, Suri; Kang, Yeon Gwi; Kim, Moon Ju; Jeong, Jeong Seong; Kim, Tae Kyun

    2017-06-01

    The 2011 Knee Society Score © (2011 KS Score © ) is used to characterize the expectations, symptoms, physical activity, and satisfaction of patients who undergo TKA and is widely used to assess the outcome of TKA. However, it has not been adapted or validated for use in Korea. We developed a Korean version of the 2011 KS Score and evaluated the (1) test-retest reliability, (2) convergent validity, and (3) responsiveness of the Korean version. The Korean version of the 2011 KS Score was derived by using a well-established translational procedure based on international guidelines, which include translation, synthesis, back-translation, expert committee review, pretesting, and submission for appraisal. A total of 123 patients with knee osteoarthritis who were scheduled to undergo TKA were recruited for the study. Ninety percent of the patients (111 of 123) were women, which is an exact representation of the Korean population having TKAs. To evaluate reliability, the patients were evaluated twice during a 4-week interval using the questionnaire. Reliability was assessed by using intraclass correlation coefficients (ICCs) and internal consistency by using Cronbach's alpha to determine the validity of the Korean version of the 2011 KS Score. The patients were evaluated by using the validated Korean versions of the WOMAC and SF-36 questionnaires. Spearman's correlation coefficient was used for validation. Responsiveness was determined by calculating the standardized response mean from the preoperative and postoperative test scores in the Korean version of the 2011 KS Score. To address the gender disparity in our study we identified 53 males who underwent TKA for osteoarthritis after completion of this study and generated age-matched controlled groups to evaluate construct validity and responsiveness in Korean males. The reliability proved good to excellent with an ICC between 0.69 and 0.85, depending on the clinical properties tested, which included the following

  1. Experience with IBS-suppression lattice in RHIC

    International Nuclear Information System (INIS)

    Litvinenko, V.N.; Luo, Y.; Ptitsyn, V.; Satogata, T.; Tepikian, S.; Bai, M.; Bruno, D.; Cameron, P.; Connolly, R.; Della Penna, A.; Drees, A.; Fedotov, A.; Ganetis, G.; Hoff, L.; Louie, W.; Malitsky, N.; Marr, G.; Marusic, A.; Montag, C.; Pilat, F.; Roser, T.; Trbojevic, D.; Tsoupas, N.

    2008-01-01

    An intra-beam scattering (IBS) is the limiting factor of the luminosity lifetime for RHIC operating with heavy ions. In order to suppress the IBS we designed and implemented new lattice with higher betatron tunes. This lattice had been developed during last three years and had been used for gold ions in yellow ring of the RHIC during d-Au part of the RHIC Run-8. The use of this lattice allowed both significant increases in the luminosity lifetime and the luminosity levels via reduction of beta-stars in the IPS. In this paper we report on the development, the tests and the performance of IBS-suppression lattice in RHIC, including the resulting increases in the peak and the average luminosity. We also report on our plans for future steps with the IBS suppression

  2. CASKETSS-2: a computer code system for thermal and structural analysis of nuclear fuel shipping casks (version 2)

    International Nuclear Information System (INIS)

    Ikushima, Takeshi

    1991-08-01

    A computer program CASKETSS-2 has been developed for the purpose of thermal and structural analysis of nuclear fuel shipping casks. CASKETSS-2 means a modular code system for CASK Evaluation code system Thermal and Structural Safety (Version 2). Main features of CASKETSS-2 are as follow; (1) Thermal and structural analysis computer programs for one-, two-, three-dimensional geometries are contained in the code system. (2) There are simplified computer programs and a detailed one in the structural analysis part in the code system. (3) Input data generator is provided in the code system. (4) Graphic computer program is provided in the code system. In the paper, brief illustration of calculation method, input data and sample calculations are presented. (author)

  3. Analysis of HgI2 and PbI2 crystals and detectors by particle-induced x-ray emission (PIXE) and ion backscattering spectroscopy (IBS)

    International Nuclear Information System (INIS)

    Bench, G.S.; Heikkinen, D.W.; Antolak, A.J.; Morse, D.H.; Pontau, A.E.; James, R.B.; David, D.C.; Burger, A.; Van Den Berg, L.

    1993-03-01

    The Ion Micro-Analysis Group (IMAG) in Livermore conducts quantitative trace elemental analysis with PIXE and depth profiling with IBS using an MeV ion microbeam. The system has the capability to produce two-dimensional trace element and IBS images. PIXE analyses have been conducted on HgI 2 and PbI 2 crystals and detector materials in order to identify and quantify near surface trace contaminants. IBS measurements have been conducted to investigate elemental depth distributions in various materials. The results of measurements on several different samples are reported and a discussion of factors affecting quantitative in vacuo microanalysis of these materials is presented

  4. The Unified Extensional Versioning Model

    DEFF Research Database (Denmark)

    Asklund, U.; Bendix, Lars Gotfred; Christensen, H. B.

    1999-01-01

    Versioning of components in a system is a well-researched field where various adequate techniques have already been established. In this paper, we look at how versioning can be extended to cover also the structural aspects of a system. There exist two basic techniques for versioning - intentional...

  5. 2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.

    Science.gov (United States)

    Carballeira, Néstor M; Cartagena, Michelle; Sanabria, David; Tasdemir, Deniz; Prada, Christopher F; Reguera, Rosa M; Balaña-Fouce, Rafael

    2012-10-01

    2-Alkynoic fatty acids display antimycobacterial, antifungal, and pesticidal activities but their antiprotozoal activity has received little attention. In this work we synthesized the 2-octadecynoic acid (2-ODA), 2-hexadecynoic acid (2-HDA), and 2-tetradecynoic acid (2-TDA) and show that 2-ODA is the best inhibitor of the Leishmania donovani DNA topoisomerase IB enzyme (LdTopIB) with an EC(50)=5.3±0.7μM. The potency of LdTopIB inhibition follows the trend 2-ODA>2-HDA>2-TDA, indicating that the effectiveness of inhibition depends on the fatty acid carbon chain length. All of the studied 2-alkynoic fatty acids were less potent inhibitors of the human topoisomerase IB enzyme (hTopIB) as compared to LdTopIB. 2-ODA also displayed in vitro activity against Leishmania donovani (IC(50)=11.0μM), but it was less effective against other protozoa, Trypanosoma cruzi (IC(50)=48.1μM) and Trypanosoma brucei rhodesiense (IC(50)=64.5μM). The antiprotozoal activity of the 2-alkynoic fatty acids, in general, followed the trend 2-ODA>2-HDA>2-TDA. The experimental information gathered so far indicates that 2-ODA is a promising antileishmanial compound. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Assessment of multi-version NPP I and C systems safety. Metric-based approach, technique and tool

    International Nuclear Information System (INIS)

    Kharchenko, Vyacheslav; Volkovoy, Andrey; Bakhmach, Eugenii; Siora, Alexander; Duzhyi, Vyacheslav

    2011-01-01

    The challenges related to problem of assessment of actual diversity level and evaluation of diversity-oriented NPP I and C systems safety are analyzed. There are risks of inaccurate assessment and problems of insufficient decreasing probability of CCFs. CCF probability of safety-critical systems may be essentially decreased due to application of several different types of diversity (multi-diversity). Different diversity types of FPGA-based NPP I and C systems, general approach and stages of diversity and safety assessment as a whole are described. Objectives of the report are: (a) analysis of the challenges caused by use of diversity approach in NPP I and C systems in context of FPGA and other modern technologies application; (b) development of multi-version NPP I and C systems assessment technique and tool based on check-list and metric-oriented approach; (c) case-study of the technique: assessment of multi-version FPGA-based NPP I and C developed by use of Radiy TM Platform. (author)

  7. Quality assurance and verification of the MACCS [MELCOR Accident Consequence Code System] code, Version 1.5

    International Nuclear Information System (INIS)

    Dobbe, C.A.; Carlson, E.R.; Marshall, N.H.; Marwil, E.S.; Tolli, J.E.

    1990-02-01

    An independent quality assurance (QA) and verification of Version 1.5 of the MELCOR Accident Consequence Code System (MACCS) was performed. The QA and verification involved examination of the code and associated documentation for consistent and correct implementation of the models in an error-free FORTRAN computer code. The QA and verification was not intended to determine either the adequacy or appropriateness of the models that are used MACCS 1.5. The reviews uncovered errors which were fixed by the SNL MACCS code development staff prior to the release of MACCS 1.5. Some difficulties related to documentation improvement and code restructuring are also presented. The QA and verification process concluded that Version 1.5 of the MACCS code, within the scope and limitations process concluded that Version 1.5 of the MACCS code, within the scope and limitations of the models implemented in the code is essentially error free and ready for widespread use. 15 refs., 11 tabs

  8. Farsi version of social skills rating system-secondary student form: cultural adaptation, reliability and construct validity.

    Science.gov (United States)

    Eslami, Ahmad Ali; Amidi Mazaheri, Maryam; Mostafavi, Firoozeh; Abbasi, Mohamad Hadi; Noroozi, Ensieh

    2014-01-01

    Assessment of social skills is a necessary requirement to develop and evaluate the effectiveness of cognitive and behavioral interventions. This paper reports the cultural adaptation and psychometric properties of the Farsi version of the social skills rating system-secondary students form (SSRS-SS) questionnaire (Gresham and Elliot, 1990), in a normative sample of secondary school students. A two-phase design was used that phase 1 consisted of the linguistic adaptation and in phase 2, using cross-sectional sample survey data, the construct validity and reliability of the Farsi version of the SSRS-SS were examined in a sample of 724 adolescents aged from 13 to 19 years. Content validity index was excellent, and the floor/ceiling effects were low. After deleting five of the original SSRS-SS items, the findings gave support for the item convergent and divergent validity. Factor analysis revealed four subscales. RESULTS showed good internal consistency (0.89) and temporal stability (0.91) for the total scale score. Findings demonstrated support for the use of the 27-item Farsi version in the school setting. Directions for future research regarding the applicability of the scale in other settings and populations of adolescents are discussed.

  9. Description of Multimedia Environment Pollutant Assessment System (MEPAS) version 3.2 modification for the Nuclear Regulatory Commission

    International Nuclear Information System (INIS)

    Buck, J.W.; Strenge, D.L.; Hoopes, B.L.

    1997-11-01

    The Multimedia Environmental Pollutant Assessment System (MEPAS) is a software tool developed by Pacific Northwest National Laboratory (PNNL) for the U.S. Department of Energy (DOE) to allow DOE to conduct human health risk analyses nation-wide. This report describes modifications to the MEPAS to meet the requirements of the U.S. Nuclear Regulatory Commission (NRC) staff in their analyses of Site Decommissioning Management Plan sites. In general, these modifications provide the MEPAS, Version 3.2, with the capability of calculating and reporting annual dose/risk information. Modifications were made to the exposure pathway and health impact modules and the water and atmospheric transport modules. Several example cases used to test the MEPAS, Version 3.2, are also presented. The MEPAS, Version 3.2, also contains a new source-term release component that includes models for estimating contaminant loss from three different types of source zones (contaminated aquifer, contaminated pond/surface impoundment, and contaminated vadose zone) due to decay/degradation, leaching, wind suspension, water erosion, overland flow, and/or volatilization. When multiple loss routes are assumed to occur simultaneously, the models account for their interaction and calculate an appropriate pollutant mass budget to each loss route over time

  10. V.S.O.P. (99/09) computer code system for reactor physics and fuel cycle simulation. Version 2009

    International Nuclear Information System (INIS)

    Ruetten, H.J.; Haas, K.A.; Brockmann, H.; Ohlig, U.; Pohl, C.; Scherer, W.

    2010-07-01

    V.S.O.P. (99/ 09) represents the further development of V.S.O.P. (99/ 05). Compared to its precursor, the code system has been improved again in many details. The main motivation for this new code version was to update the basic nuclear libraries used by the code system. Thus, all cross section libraries involved in the code have now been based on ENDF/B-VII. V.S.O.P. is a computer code system for the comprehensive numerical simulation of the physics of thermal reactors. It implies the setup of the reactor and of the fuel element, processing of cross sections, neutron spectrum evaluation, neutron diffusion calculation in two or three dimensions, fuel burnup, fuel shuffling, reactor control, thermal hydraulics and fuel cycle costs. The thermal hydraulics part (steady state and time-dependent) is restricted to gas-cooled reactors and to two spatial dimensions. The code can simulate the reactor operation from the initial core towards the equilibrium core. This latest code version was developed and tested under the WINDOWS-XP - operating system. (orig.)

  11. V.S.O.P. (99/09) computer code system for reactor physics and fuel cycle simulation. Version 2009

    Energy Technology Data Exchange (ETDEWEB)

    Ruetten, H.J.; Haas, K.A.; Brockmann, H.; Ohlig, U.; Pohl, C.; Scherer, W.

    2010-07-15

    V.S.O.P. (99/ 09) represents the further development of V.S.O.P. (99/ 05). Compared to its precursor, the code system has been improved again in many details. The main motivation for this new code version was to update the basic nuclear libraries used by the code system. Thus, all cross section libraries involved in the code have now been based on ENDF/B-VII. V.S.O.P. is a computer code system for the comprehensive numerical simulation of the physics of thermal reactors. It implies the setup of the reactor and of the fuel element, processing of cross sections, neutron spectrum evaluation, neutron diffusion calculation in two or three dimensions, fuel burnup, fuel shuffling, reactor control, thermal hydraulics and fuel cycle costs. The thermal hydraulics part (steady state and time-dependent) is restricted to gas-cooled reactors and to two spatial dimensions. The code can simulate the reactor operation from the initial core towards the equilibrium core. This latest code version was developed and tested under the WINDOWS-XP - operating system. (orig.)

  12. Implementation of methane cycling for deep time, global warming simulations with the DCESS Earth System Model (Version 1.2)

    DEFF Research Database (Denmark)

    Shaffer, Gary; Villanueva, Esteban Fernández; Rondanelli, Roberto

    2017-01-01

    Geological records reveal a number of ancient, large and rapid negative excursions of carbon-13 isotope. Such excursions can only be explained by massive injections of depleted carbon to the Earth System over a short duration. These injections may have forced strong global warming events, sometimes....... With this improved DCESS model version and paleo-reconstructions, we are now better armed to gauge the amounts, types, time scales and locations of methane injections driving specific, observed deep time, global warming events....

  13. IMG 4 version of the integrated microbial genomes comparative analysis system

    Science.gov (United States)

    Markowitz, Victor M.; Chen, I-Min A.; Palaniappan, Krishna; Chu, Ken; Szeto, Ernest; Pillay, Manoj; Ratner, Anna; Huang, Jinghua; Woyke, Tanja; Huntemann, Marcel; Anderson, Iain; Billis, Konstantinos; Varghese, Neha; Mavromatis, Konstantinos; Pati, Amrita; Ivanova, Natalia N.; Kyrpides, Nikos C.

    2014-01-01

    The Integrated Microbial Genomes (IMG) data warehouse integrates genomes from all three domains of life, as well as plasmids, viruses and genome fragments. IMG provides tools for analyzing and reviewing the structural and functional annotations of genomes in a comparative context. IMG’s data content and analytical capabilities have increased continuously since its first version released in 2005. Since the last report published in the 2012 NAR Database Issue, IMG’s annotation and data integration pipelines have evolved while new tools have been added for recording and analyzing single cell genomes, RNA Seq and biosynthetic cluster data. Different IMG datamarts provide support for the analysis of publicly available genomes (IMG/W: http://img.jgi.doe.gov/w), expert review of genome annotations (IMG/ER: http://img.jgi.doe.gov/er) and teaching and training in the area of microbial genome analysis (IMG/EDU: http://img.jgi.doe.gov/edu). PMID:24165883

  14. IMG 4 version of the integrated microbial genomes comparative analysis system

    Energy Technology Data Exchange (ETDEWEB)

    Markowitz, Victor M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Data Management and Technology Center. Computational Research Division; Chen, I-Min A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Data Management and Technology Center. Computational Research Division; Palaniappan, Krishna [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Data Management and Technology Center. Computational Research Division; Chu, Ken [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Data Management and Technology Center. Computational Research Division; Szeto, Ernest [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Data Management and Technology Center. Computational Research Division; Pillay, Manoj [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Data Management and Technology Center. Computational Research Division; Ratner, Anna [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Data Management and Technology Center. Computational Research Division; Huang, Jinghua [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Biological Data Management and Technology Center. Computational Research Division; Woyke, Tanja [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States). Microbial Genome and Metagenome Program; Huntemann, Marcel [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States). Microbial Genome and Metagenome Program; Anderson, Iain [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States). Microbial Genome and Metagenome Program; Billis, Konstantinos [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States). Microbial Genome and Metagenome Program; Varghese, Neha [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States). Microbial Genome and Metagenome Program; Mavromatis, Konstantinos [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States). Microbial Genome and Metagenome Program; Pati, Amrita [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States). Microbial Genome and Metagenome Program; Ivanova, Natalia N. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States). Microbial Genome and Metagenome Program; Kyrpides, Nikos C. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States). Microbial Genome and Metagenome Program

    2013-10-27

    The Integrated Microbial Genomes (IMG) data warehouse integrates genomes from all three domains of life, as well as plasmids, viruses and genome fragments. IMG provides tools for analyzing and reviewing the structural and functional annotations of genomes in a comparative context. IMG’s data content and analytical capabilities have increased continuously since its first version released in 2005. Since the last report published in the 2012 NAR Database Issue, IMG’s annotation and data integration pipelines have evolved while new tools have been added for recording and analyzing single cell genomes, RNA Seq and biosynthetic cluster data. Finally, different IMG datamarts provide support for the analysis of publicly available genomes (IMG/W: http://img.jgi.doe.gov/w), expert review of genome annotations (IMG/ER: http://img.jgi.doe.gov/er) and teaching and training in the area of microbial genome analysis (IMG/EDU: http://img.jgi.doe.gov/edu).

  15. Accelerator System Model (ASM) user manual with physics and engineering model documentation. ASM version 1.0

    International Nuclear Information System (INIS)

    1993-07-01

    The Accelerator System Model (ASM) is a computer program developed to model proton radiofrequency accelerators and to carry out system level trade studies. The ASM FORTRAN subroutines are incorporated into an intuitive graphical user interface which provides for the open-quotes constructionclose quotes of the accelerator in a window on the computer screen. The interface is based on the Shell for Particle Accelerator Related Codes (SPARC) software technology written for the Macintosh operating system in the C programming language. This User Manual describes the operation and use of the ASM application within the SPARC interface. The Appendix provides a detailed description of the physics and engineering models used in ASM. ASM Version 1.0 is joint project of G. H. Gillespie Associates, Inc. and the Accelerator Technology (AT) Division of the Los Alamos National Laboratory. Neither the ASM Version 1.0 software nor this ASM Documentation may be reproduced without the expressed written consent of both the Los Alamos National Laboratory and G. H. Gillespie Associates, Inc

  16. Accelerator System Model (ASM) user manual with physics and engineering model documentation. ASM version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-07-01

    The Accelerator System Model (ASM) is a computer program developed to model proton radiofrequency accelerators and to carry out system level trade studies. The ASM FORTRAN subroutines are incorporated into an intuitive graphical user interface which provides for the {open_quotes}construction{close_quotes} of the accelerator in a window on the computer screen. The interface is based on the Shell for Particle Accelerator Related Codes (SPARC) software technology written for the Macintosh operating system in the C programming language. This User Manual describes the operation and use of the ASM application within the SPARC interface. The Appendix provides a detailed description of the physics and engineering models used in ASM. ASM Version 1.0 is joint project of G. H. Gillespie Associates, Inc. and the Accelerator Technology (AT) Division of the Los Alamos National Laboratory. Neither the ASM Version 1.0 software nor this ASM Documentation may be reproduced without the expressed written consent of both the Los Alamos National Laboratory and G. H. Gillespie Associates, Inc.

  17. More negative self-esteem and inferior coping strategies among patients diagnosed with IBS compared with patients without IBS--a case-control study in primary care.

    Science.gov (United States)

    Grodzinsky, Ewa; Walter, Susanna; Viktorsson, Lisa; Carlsson, Ann-Kristin; Jones, Michael P; Faresjö, Åshild

    2015-01-28

    Irritable Bowel Syndrome (IBS) is a chronic, relapsing gastrointestinal disorder, that affects approximately 10% of the general population and the majority are diagnosed in primary care. IBS has been reported to be associated with altered psychological and cognitive functioning such as mood disturbances, somatization, catastrophizing or altered visceral interoception by negative emotions and stress. The aim was to investigate the psychosocial constructs of self-esteem and sense of coherence among IBS patients compared to non-IBS patients in primary care. A case-control study in primary care setting among IBS patients meeting the ROME III criteria (n = 140) compared to controls i.e. non-IBS patients (n = 213) without any present or previous gastrointestinal complaints. The data were collected through self-reported questionnaires of psychosocial factors. IBS-patients reported significantly more negative self-esteem (p IBS-cases were also less likely to report 'good' health status (p IBS patients remained statistically significant (p = 0.02), as did the lower scores for sense of coherence among IBS cases (p = 0.04). The more frequently reported negative self-esteem and inferior coping strategies among IBS patients found in this study suggest the possibility that psychological therapies might be helpful for these patients. However these data do not indicate the causal direction of the observed associations. More research is therefore warranted to determine whether these psychosocial constructs are more frequent in IBS patients.

  18. User's Manual for the Naval Interactive Data Analysis System-Climatologies (NIDAS-C), Version 2.0

    Science.gov (United States)

    Abbott, Clifton

    1996-01-01

    This technical note provides the user's manual for the NIDAS-C system developed for the naval oceanographic office. NIDAS-C operates using numerous oceanographic data categories stored in an installed version of the Naval Environmental Operational Nowcast System (NEONS), a relational database management system (rdbms) which employs the ORACLE proprietary rdbms engine. Data management, configuration, and control functions for the supporting rdbms are performed externally. NIDAS-C stores and retrieves data to/from the rdbms but exercises no direct internal control over the rdbms or its configuration. Data is also ingested into the rdbms, for use by NIDAS-C, by external data acquisition processes. The data categories employed by NIDAS-C are as follows: Bathymetry - ocean depth at

  19. Protein kinase activity associated with the corticosteroid binder IB

    International Nuclear Information System (INIS)

    Vujicic, M.; Djordjevic-Markovic, R.; Radic, O.; Krstic, M.; Kanazir, D.

    1997-01-01

    The physiological effects elicited by glucocorticoids are mediated via glucocorticoid receptors (GR). Analysis of specific glucocorticoid binding to radioactively labelled [ 3 H] triamcinolone acetonide in rat liver cytosol and analysis by ion exchange chromatography have revealed the presence of two distinct molecular species. The major form, designated as binder II appears to correspond to the well characterized glucocorticoid receptor by virtue of its size, charge, steroid binding characteristics and ability to bind to DNA.The second form, designated as corticosteroid binder IB, is a minor binding component in the liver. The binder IB differs from the binder II receptor by virtue of its lower molecular weight and its elution in the pre gradient of DEAE-Sephadex A-50 column which retains the un activated binder II receptor complexes. We examined the kinase activity of partially purified corticosteroid binder IB. Using (γ 3 2 P) ATP we detected kinase activity associated with the IB fraction from the rat liver. This kinase phosphorylate mixed histones and and dose not phosphorylate IB protein in vitro. The kinase activity is completely inhibited by the addition of Mg 2 + ions and is partially inhibited by the addition of Ca 2 +ions. (author)

  20. HLA class Ib in pregnancy and pregnancy-related disorders.

    Science.gov (United States)

    Persson, Gry; Melsted, Wenna Nascimento; Nilsson, Line Lynge; Hviid, Thomas Vauvert F

    2017-08-01

    The HLA class Ib genes, HLA-E, HLA-F, and HLA-G, were discovered long after the classical HLA class Ia genes. The elucidation of their functions had a modest beginning. However, their basic functions and involvement in pathophysiology and a range of diseases are now emerging. Although results from a range of studies support the functional roles for the HLA class Ib molecules in adult life, especially HLA-G and HLA-F have most intensively been, and were also primarily, studied in relation to reproduction and pregnancy. The expression of HLA class Ib proteins at the feto-maternal interface in the placenta seems to be important for the maternal acceptance of the semi-allogenic fetus. In contrast to the functions of HLA class Ia, HLA-G possesses immune-modulatory and tolerogenic functions. Here, we review an accumulating amount of data describing the functions of HLA class Ib molecules in relation to fertility, reproduction, and pregnancy, and a possible role for these molecules in certain pregnancy complications, such as implantation failure, recurrent spontaneous abortions, and pre-eclampsia. The results from different kinds of studies point toward a role for HLA class Ib, especially HLA-G, throughout the reproductive cycle from conception to the birth weight of the child.

  1. The Systems Biology Markup Language (SBML) Level 3 Package: Qualitative Models, Version 1, Release 1.

    Science.gov (United States)

    Chaouiya, Claudine; Keating, Sarah M; Berenguier, Duncan; Naldi, Aurélien; Thieffry, Denis; van Iersel, Martijn P; Le Novère, Nicolas; Helikar, Tomáš

    2015-09-04

    Quantitative methods for modelling biological networks require an in-depth knowledge of the biochemical reactions and their stoichiometric and kinetic parameters. In many practical cases, this knowledge is missing. This has led to the development of several qualitative modelling methods using information such as, for example, gene expression data coming from functional genomic experiments. The SBML Level 3 Version 1 Core specification does not provide a mechanism for explicitly encoding qualitative models, but it does provide a mechanism for SBML packages to extend the Core specification and add additional syntactical constructs. The SBML Qualitative Models package for SBML Level 3 adds features so that qualitative models can be directly and explicitly encoded. The approach taken in this package is essentially based on the definition of regulatory or influence graphs. The SBML Qualitative Models package defines the structure and syntax necessary to describe qualitative models that associate discrete levels of activities with entity pools and the transitions between states that describe the processes involved. This is particularly suited to logical models (Boolean or multi-valued) and some classes of Petri net models can be encoded with the approach.

  2. JEnsembl: a version-aware Java API to Ensembl data systems.

    Science.gov (United States)

    Paterson, Trevor; Law, Andy

    2012-11-01

    The Ensembl Project provides release-specific Perl APIs for efficient high-level programmatic access to data stored in various Ensembl database schema. Although Perl scripts are perfectly suited for processing large volumes of text-based data, Perl is not ideal for developing large-scale software applications nor embedding in graphical interfaces. The provision of a novel Java API would facilitate type-safe, modular, object-orientated development of new Bioinformatics tools with which to access, analyse and visualize Ensembl data. The JEnsembl API implementation provides basic data retrieval and manipulation functionality from the Core, Compara and Variation databases for all species in Ensembl and EnsemblGenomes and is a platform for the development of a richer API to Ensembl datasources. The JEnsembl architecture uses a text-based configuration module to provide evolving, versioned mappings from database schema to code objects. A single installation of the JEnsembl API can therefore simultaneously and transparently connect to current and previous database instances (such as those in the public archive) thus facilitating better analysis repeatability and allowing 'through time' comparative analyses to be performed. Project development, released code libraries, Maven repository and documentation are hosted at SourceForge (http://jensembl.sourceforge.net).

  3. Effect of software version and parameter settings on the marginal and internal adaptation of crowns fabricated with the CAD/CAM system.

    Science.gov (United States)

    Shim, Ji Suk; Lee, Jin Sook; Lee, Jeong Yol; Choi, Yeon Jo; Shin, Sang Wan; Ryu, Jae Jun

    2015-10-01

    This study investigated the marginal and internal adaptation of individual dental crowns fabricated using a CAD/CAM system (Sirona's BlueCam), also evaluating the effect of the software version used, and the specific parameter settings in the adaptation of crowns. Forty digital impressions of a master model previously prepared were acquired using an intraoral scanner and divided into four groups based on the software version and on the spacer settings used. The versions 3.8 and 4.2 of the software were used, and the spacer parameter was set at either 40 μm or 80 μm. The marginal and internal fit of the crowns were measured using the replica technique, which uses a low viscosity silicone material that simulates the thickness of the cement layer. The data were analyzed using a Friedman two-way analysis of variance (ANOVA) and paired t-tests with significance level set at psoftware version (psoftware showed a better fit than those designed with the version 3.8, particularly in the axial wall and in the inner margin. The spacer parameter was more accurately represented in the version 4.2 of the software than in the version 3.8. In addition, the use of the version 4.2 of the software combined with the spacer parameter set at 80 μm showed the least variation. On the other hand, the outer margin was not affected by the variables. Compared to the version 3.8 of the software, the version 4.2 can be recommended for the fabrication of well-fitting crown restorations, and for the appropriate regulation of the spacer parameter.

  4. OC5 Project Phase Ib: Validation of Hydrodynamic Loading on a Fixed, Flexible Cylinder for Offshore Wind Applications

    DEFF Research Database (Denmark)

    Robertson, Amy N.; Wendt, Fabian; Jonkman, Jason M.

    2016-01-01

    at the Danish Hydraulic Institute (DHI) with support from the Technical University of Denmark (DTU). The first phase of OC5 examined two simple cylinder structures (Phase Ia and Ib) to focus on validation of hydrodynamic models used in the various tools before moving on to more complex offshore wind systems...

  5. Descending pain modulation in irritable bowel syndrome (IBS): a systematic review and meta-analysis.

    Science.gov (United States)

    Chakiath, Rosemary J; Siddall, Philip J; Kellow, John E; Hush, Julia M; Jones, Mike P; Marcuzzi, Anna; Wrigley, Paul J

    2015-12-10

    Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. While abdominal pain is a dominant symptom of IBS, many sufferers also report widespread hypersensitivity and present with other chronic pain conditions. The presence of widespread hypersensitivity and extra-intestinal pain conditions suggests central nervous dysfunction. While central nervous system dysfunction may involve the spinal cord (central sensitisation) and brain, this review will focus on one brain mechanism, descending pain modulation. We will conduct a comprehensive search for the articles indexed in the databases Ovid MEDLINE, Ovid Embase, Ovid PsycINFO and Cochrane Central Register of Controlled Trial (CENTRAL) from their inception to August 2015, that report on any aspect of descending pain modulation in irritable bowel syndrome. Two independent reviewers will screen studies for eligibility, assess risk of bias and extract relevant data. Results will be tabulated and, if possible, a meta-analysis will be carried out. The systematic review outlined in this protocol aims to summarise current knowledge regarding descending pain modulation in IBS. PROSPERO CRD42015024284.

  6. MATS--Management Accounting Tutorial System. Version 1.0. Project Documentation.

    Science.gov (United States)

    Wardle, Andrew; O'Connor, Rodric

    The Management Accounting Tutorial System (MATS) is a management accounting database for a carpet manufacturing company. The system allows the display and output of monthly activities, and is intended to provide a means of illustrating the main topics of the second year management accounting course at Manchester University. The system itself…

  7. MATS--Management Accounting Tutorial System. Version 1.0. User Guide.

    Science.gov (United States)

    Wardle, Andrew; O'Connor, Rodric

    The Management Accounting Tutorial System (MATS) is a management accounting database for a carpet manufacturing company. The system allows the display and output of monthly activities, and is intended to provide a means of illustrating the main topics of the second year management accounting course at Manchester University. The system itself…

  8. Paternal uniparental isodisomy of the entire chromosome 20 as a molecular cause of pseudohypoparathyroidism type Ib (PHP-Ib).

    Science.gov (United States)

    Bastepe, Murat; Altug-Teber, Ozge; Agarwal, Chhavi; Oberfield, Sharon E; Bonin, Michael; Jüppner, Harald

    2011-03-01

    Pseudohypoparathyoridism type Ib (PHP-Ib) typically defines the presence of end-organ resistance to parathyroid hormone in the absence of Albright's hereditary osteodystrophy. Patients affected by this disorder present with imprinting defects in the complex GNAS locus. Microdeletions within STX16 or GNAS have been identified in familial cases with PHP-Ib, but the molecular cause of the GNAS imprinting defects in sporadic PHP-Ib cases remains poorly defined. We now report a case with sporadic PHP-Ib for whom a SNPlex analysis revealed loss of the maternal GNAS allele. Further analysis of the entire genome with a 100K SNP chip identified a paternal uniparental isodisomy affecting the entire chromosome 20 without evidence for another chromosomal abnormality. Our findings explain the observed GNAS methylation changes and the patient's hormone resistance, and furthermore suggest that chromosome 20 harbors, besides GNAS, no additional imprinted region that contributes to the clinical and laboratory phenotype. Copyright © 2010 Elsevier Inc. All rights reserved.

  9. The Chinese version of monitoring and evaluation system strengthening tool for human immunodeficiency virus (HIV) capacity building: Development and evaluation.

    Science.gov (United States)

    Zhao, Ran; Chen, Ren; Zhang, Bing; Ma, Ying; Qin, Xia; Hu, Zhi

    2015-08-01

    Monitoring and evaluation (M&E) for human immunodeficiency virus (HIV) capacity building has become a significant step for HIV prevention and control. The M&E system strengthening tool published by the United Nations Joint Programme on HIV/AIDS (UNAIDS) was intended to be the most authoritative assessment tool internationally. Facing the fact that the M&E system in China did not function at an optimum level, we considered taking the international standards for reference. By linguistic validating and different stages' discussions and revisions, we came up with the Chinese version of the capacity diagnosis tool with at least 12 components and tested its validity and reliability. The tool turned out to have a sufficiently linguistic validation and proved to be a scientific and feasible instrument which was suitable for China's national conditions.

  10. Applying a Danish version of the Learning Transfer System Inventory and testing it for different types of education

    DEFF Research Database (Denmark)

    Sørensen, Peter; Stegeager, Nikolaj W.M.; Bates, Reid

    2017-01-01

    in the original American LTSI. The study also found that the mean score differs in a statistically significant way between the different types of education. Specifically, LTSI may be more suitable in measuring transfer systems and therefore promoting transfer in relation to short courses offering training......The purpose of this study was to answer two research questions. First, will an exploratory factor analysis of a Danish version of the Learning Transfer System Inventory (LTSI) result in a factor structure which is consistent with the original American LTSI factor structure? Second, does the mean...... score in the factor analysis vary in a statistically significant way across different types of education, suggesting that the LTSI may be more suitable a measure in some educational contexts than others? To answer these questions survey data from 411 students following four different types of formal...

  11. Implementation of methane cycling for deep time, global warming simulations with the DCESS Earth System Model (Version 1.2)

    DEFF Research Database (Denmark)

    Shaffer, Gary; Villanueva, Esteban Fernández; Rondanelli, Roberto

    2017-01-01

    Geological records reveal a number of ancient, large and rapid negative excursions of carbon-13 isotope. Such excursions can only be explained by massive injections of depleted carbon to the Earth System over a short duration. These injections may have forced strong global warming events, sometimes....... With this improved DCESS model version and paleo-reconstructions, we are now better armed to gauge the amounts, types, time scales and locations of methane injections driving specific, observed deep time, global warming events......., or from warming-induced dissociation of methane hydrate, a solid compound of methane and water found in ocean sediments. As a consequence of the ubiquity and importance of methane in major Earth events, Earth System models should include a comprehensive treatment of methane cycling but such a treatment...

  12. WASTES: Wastes system transportation and economic simulation: Version 2, Programmer's reference manual

    International Nuclear Information System (INIS)

    Buxbaum, M.E.; Shay, M.R.

    1986-11-01

    The WASTES Version II (WASTES II) Programmer's Reference Manual was written to document code development activities performed under the Monitored Retrievable Storage (MRS) Program at Pacific Northwest Laboratory (PNL). The manual will also serve as a valuable tool for programmers involved in maintenance of and updates to the WASTES II code. The intended audience for this manual are experienced FORTRAN programmers who have only a limited knowledge of nuclear reactor operation, the nuclear fuel cycle, or nuclear waste management practices. It is assumed that the readers of this manual have previously reviewed the WASTES II Users Guide published as PNL Report 5714. The WASTES II code is written in FORTRAN 77 as an extension to the SLAM commercial simulation package. The model is predominately a FORTRAN based model that makes extensive use of the SLAM file maintenance and time management routines. This manual documents the general manner in which the code is constructed and the interactions between SLAM and the WASTES subroutines. The functionality of each of the major WASTES subroutines is illustrated with ''block flow'' diagrams. The basic function of each of these subroutines, the algorithms used in them, and a discussion of items of particular note in the subroutine are reviewed in this manual. The items of note may include an assumption, a coding practice that particularly applies to a subroutine, or sections of the code that are particularly intricate or whose mastery may be difficult. The appendices to the manual provide extensive detail on the use of arrays, subroutines, included common blocks, parameters, variables, and files

  13. User manual of the CATSS system (version 1.0) communication analysis tool for space station

    Science.gov (United States)

    Tsang, C. S.; Su, Y. T.; Lindsey, W. C.

    1983-01-01

    The Communication Analysis Tool for the Space Station (CATSS) is a FORTRAN language software package capable of predicting the communications links performance for the Space Station (SS) communication and tracking (C & T) system. An interactive software package was currently developed to run on the DEC/VAX computers. The CATSS models and evaluates the various C & T links of the SS, which includes the modulation schemes such as Binary-Phase-Shift-Keying (BPSK), BPSK with Direct Sequence Spread Spectrum (PN/BPSK), and M-ary Frequency-Shift-Keying with Frequency Hopping (FH/MFSK). Optical Space Communication link is also included. CATSS is a C & T system engineering tool used to predict and analyze the system performance for different link environment. Identification of system weaknesses is achieved through evaluation of performance with varying system parameters. System tradeoff for different values of system parameters are made based on the performance prediction.

  14. IDC Re-Engineering Phase 2 System Specification Document Version 1.5

    Energy Technology Data Exchange (ETDEWEB)

    Satpathi, Meara Allena [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Burns, John F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Harris, James M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-01-01

    This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Re-Engineering Phase 2 project. This System Specification Document (SSD) defines waveform data processing requirements for the International Data Centre (IDC) of the Comprehensive Nuclear Test Ban Treaty Organization (CTBTO). The routine processing includes characterization of events with the objective of screening out events considered to be consistent with natural phenomena or non-nuclear, man-made phenomena. This document does not address requirements concerning acquisition, processing and analysis of radionuclide data but does include requirements for the dissemination of radionuclide data and products.

  15. Federal Emergency Management Information System (FEMIS) Installation Guide for FEMIS Version 1.5

    Energy Technology Data Exchange (ETDEWEB)

    Burnett, Robert A.(BATTELLE (PACIFIC NW LAB)); Carter, Richard J.(BATTELLE (PACIFIC NW LAB)); Downing, Timothy R.(BATTELLE (PACIFIC NW LAB)); Dunkle, Julie R.(BATTELLE (PACIFIC NW LAB)); Homer, Brian J.(BATTELLE (PACIFIC NW LAB)); Johnson, Daniel M.(BATTELLE (PACIFIC NW LAB)); Johnson, Ranata L.(BATTELLE (PACIFIC NW LAB)); Johnson, Sharon M.(BATTELLE (PACIFIC NW LAB)); Loveall, Robert M.(BATTELLE (PACIFIC NW LAB)); Ramos Jr., Juan (BATTELLE (PACIFIC NW LAB)); Stephan, Alex J.(BATTELLE (PACIFIC NW LAB)); Wood, Blanche M.(BATTELLE (PACIFIC NW LAB))

    2001-12-01

    The Federal Emergency Management System (FEMIS) is an emergency management planning and response tool. The FEMIS Installation Guide provides instructions for installing and configuring the FEMIS software package.

  16. Diffusivity database (DDB) system for major rocks (Version of 2006/specification and CD-ROM)

    International Nuclear Information System (INIS)

    Tochigi, Yoshikatsu; Sasamoto, Hirosi; Shibata, Masahiro; Sato, Haruo; Yui, Mikazu

    2006-03-01

    The development of the database system has been started to manage with the generally used. The database system has been constructed based on datasheets of the effective diffusion coefficient of the nuclides in the rock matrix in order to be applied on the 'H12: Project to Establish the Scientific and Technical Basis for HLW Disposal in Japan'. In this document, the examination and expansion of the datasheet structure and the process of construction of the database system and conversion of all data existing on datasheets are described. As the first step of the development of the database, this database system and its data will continue to be updated and the interface will be revised to improve the availability. The developed database system is attached on the CD-ROM as the file format of Microsoft Access. (author)

  17. Federal Emergency Management Information System (FEMIS) data management guide, version 1.4.5

    Energy Technology Data Exchange (ETDEWEB)

    Burnett, R.A.; Downing, T.R.; Gaustad, K.L. [and others

    1998-06-26

    The Federal Emergency Management Information System (FEMIS) information resources are described in this FEMIS Data Management Guide. To comprehend what types of data are present, where the data is located, and how it is managed during the life span of the system, a basic understanding of the FEMIS architecture is necessary. The system is being developed by Pacific Northwest National Laboratory (PNNL) and is designed for a single Chemical Stockpile Emergency Preparedness Program (CSEPP) site that has multiple Emergency Operations Centers (EOCs). The capability to connect to remote CSEPP sites and share information will be present in a future release. Each EOC has personal computers (PCs) that emergency planners and operations personnel use to do their jobs. These PCs are connected via a local area network (LAN) to servers that provide efficient EOC-wide services. Each EOC is interconnected to other EOCs via telecommunications links. FEMIS is a client/server system where much of the application software is located in the client PC. This client software integrates the FEMIS application, government furnished dispersion and evacuation models, and Commercial-Off-The-Shelf (COTS) software tools such as the ArcView geographic information system (GIS) and Microsoft Project (electron planning). A UNIX server provides data management services, ARC/INFO GIS capabilities, evacuation (Evac) modeling, electron main (E-mail), and meteorological (Met) input processing. A PC communication utility is available to interface with external subsystems. At this time, the weather collection system (Handar Met System) is the only external subsystem.

  18. Systems Biology Graphical Notation: Entity Relationship language Level 1 Version 2

    Directory of Open Access Journals (Sweden)

    Sorokin Anatoly

    2015-06-01

    Full Text Available The Systems Biological Graphical Notation (SBGN is an international community effort for standardized graphical representations of biological pathways and networks. The goal of SBGN is to provide unambiguous pathway and network maps for readers with different scientific backgrounds as well as to support efficient and accurate exchange of biological knowledge between different research communities, industry, and other players in systems biology. Three SBGN languages, Process Description (PD, Entity Relationship (ER and Activity Flow (AF, allow for the representation of different aspects of biological and biochemical systems at different levels of detail.

  19. Systems Biology Graphical Notation: Activity Flow language Level 1 Version 1.2

    Directory of Open Access Journals (Sweden)

    Mi Huaiyu

    2015-06-01

    Full Text Available The Systems Biological Graphical Notation (SBGN is an international community effort for standardized graphical representations of biological pathways and networks. The goal of SBGN is to provide unambiguous pathway and network maps for readers with different scientific backgrounds as well as to support efficient and accurate exchange of biological knowledge between different research communities, industry, and other players in systems biology. Three SBGN languages, Process Description (PD, Entity Relationship (ER and Activity Flow (AF, allow for the representation of different aspects of biological and biochemical systems at different levels of detail.

  20. Generalized Fluid System Simulation Program (GFSSP) Version 6 - General Purpose Thermo-Fluid Network Analysis Software

    Science.gov (United States)

    Majumdar, Alok; Leclair, Andre; Moore, Ric; Schallhorn, Paul

    2011-01-01

    GFSSP stands for Generalized Fluid System Simulation Program. It is a general-purpose computer program to compute pressure, temperature and flow distribution in a flow network. GFSSP calculates pressure, temperature, and concentrations at nodes and calculates flow rates through branches. It was primarily developed to analyze Internal Flow Analysis of a Turbopump Transient Flow Analysis of a Propulsion System. GFSSP development started in 1994 with an objective to provide a generalized and easy to use flow analysis tool for thermo-fluid systems.

  1. Step 1: Human System Interface (HSI) Functional Requirements Document (FRD). Version 2

    Science.gov (United States)

    2006-01-01

    This Functional Requirements Document (FRD) establishes a minimum set of Human System Interface (HSI) functional requirements to achieve the Access 5 Vision of "operating High Altitude, Long Endurance (HALE) Unmanned Aircraft Systems (UAS) routinely, safely, and reliably in the National Airspace System (NAS)". Basically, it provides what functions are necessary to fly UAS in the NAS. The framework used to identify the appropriate functions was the "Aviate, Navigate, Communicate, and Avoid Hazards" structure identified in the Access 5 FRD. As a result, fifteen high-level functional requirements were developed. In addition, several of them have been decomposed into low-level functional requirements to provide more detail.

  2. Systems Security Engineering Capability Maturity Model (SSECMM), Model Description, Version 1.1

    National Research Council Canada - National Science Library

    1997-01-01

    This document is designed to acquaint the reader with the SSE-CMM Project as a whole and present the project's major work product - the Systems Security Engineering Capability Maturity Model (SSE- CMM...

  3. Adult Central Nervous System Tumors Treatment (PDQ®)—Patient Version

    Science.gov (United States)

    Adult central nervous system tumor treatment may include surgery, radiosurgery, radiation therapy, chemotherapy, surveillance, and targeted therapy. Treatment depends on the tumor type. Learn more about brain and spinal tumor treatment in this expert-reviewed summary.

  4. Childhood Central Nervous System Embryonal Tumors Treatment (PDQ®)—Patient Version

    Science.gov (United States)

    Childhood central nervous system embryonal tumors and pineal tumors are treated with surgery, radiation therapy, chemotherapy, high-dose chemotherapy with stem cell rescue and targeted therapy. Learn more in this expert-reviewed summary.

  5. Adult Central Nervous System Tumors Treatment (PDQ®)—Health Professional Version

    Science.gov (United States)

    Adult central nervous system tumor treatment options include surgery, radiosurgery, radiation therapy, chemotherapy, surveillance, and supportive care. Get detailed information about the types and treatment of newly diagnosed and recurrent brain and spinal tumors in this clinician summary.

  6. Federal Emergency Management Information system (FEMIS) data management guide. Version 1.2

    Energy Technology Data Exchange (ETDEWEB)

    Burnett, R.A.; Downing, T.R.; Gaustad, K.L.; Johnson, S.M.; Loveall, R.M.; Winters, C.

    1996-05-01

    The Federal Emergency Management Information System (FEMIS) is an emergency management planning and analysis tool that is being developed under the direction of the US Army Chemical and Biological Defense Command. The FEMIS Data Management Guide provides the background, as well as the operations and procedures needed to generate and maintain the data resources in the system. Database administrators, system administrators, and general users can use this guide to manage the data files and database that support the administrative, user-environment, database management, and operational capabilities of FEMIS. This document provides a description of the relational and spatial information present in FEMIS. It describes how the data was assembled, how it is loaded, and how it is managed while the system is in operation.

  7. MAPSS: Mapped Atmosphere-Plant-Soil System Model, Version 1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: MAPSS (Mapped Atmosphere-Plant-Soil System) is a landscape to global vegetation distribution model that was developed to simulate the potential biosphere...

  8. MAPSS: Mapped Atmosphere-Plant-Soil System Model, Version 1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — MAPSS (Mapped Atmosphere-Plant-Soil System) is a landscape to global vegetation distribution model that was developed to simulate the potential biosphere impacts and...

  9. Using Climate Regionalization to Understand Climate Forecast System Version 2 (CFSv2) Precipitation Performance for the Conterminous United States (CONUS)

    Science.gov (United States)

    Regonda, Satish K.; Zaitchik, Benjamin F.; Badr, Hamada S.; Rodell, Matthew

    2016-01-01

    Dynamically based seasonal forecasts are prone to systematic spatial biases due to imperfections in the underlying global climate model (GCM). This can result in low-forecast skill when the GCM misplaces teleconnections or fails to resolve geographic barriers, even if the prediction of large-scale dynamics is accurate. To characterize and address this issue, this study applies objective climate regionalization to identify discrepancies between the Climate Forecast SystemVersion 2 (CFSv2) and precipitation observations across the Contiguous United States (CONUS). Regionalization shows that CFSv2 1 month forecasts capture the general spatial character of warm season precipitation variability but that forecast regions systematically differ from observation in some transition zones. CFSv2 predictive skill for these misclassified areas is systematically reduced relative to correctly regionalized areas and CONUS as a whole. In these incorrectly regionalized areas, higher skill can be obtained by using a regional-scale forecast in place of the local grid cell prediction.

  10. Wien Automatic System Planning (WASP) Package. A computer code for power generating system expansion planning. Version WASP-IV. User's manual

    International Nuclear Information System (INIS)

    2001-01-01

    As a continuation of its efforts to provide methodologies and tools to Member States to carry out comparative assessment and analyse priority environmental issues related to the development of the electric power sector, the IAEA has completed a new version of the Wien Automatic System Planning (WASP) Package WASP-IV for carrying out power generation expansion planning taking into consideration fuel availability and environmental constraints. This manual constitutes a part of this work and aims to provide users with a guide to use effectively the new version of the model WASP-IV. WASP was originally developed in 1972 by the Tennessee Valley Authority and the Oak Ridge National Laboratory in the USA to meet the IAEA needs to analyse the economic competitiveness of nuclear power in comparison to other generation expansion alternatives for supplying the future electricity requirements of a country or region. Previous versions of the model were used by Member States in many national and regional studies to analyse the electric power system expansion planning and the role of nuclear energy in particular. Experience gained from its application allowed development of WASP into a very comprehensive planning tool for electric power system expansion analysis. New, improved versions were developed, which took into consideration the needs expressed by the users of the programme in order to address important emerging issues being faced by the electric system planners. In 1979, WASP-IV was released and soon after became an indispensable tool in many Member States for generation expansion planning. The WASP-IV version was continually upgraded and the development of version WASP-III Plus commenced in 1992. By 1995, WASP-III Plus was completed, which followed closely the methodology of the WASP-III but incorporated new features. In order to meet the needs of electricity planners and following the recommendations of the Helsinki symposium, development of a new version of WASP was

  11. Federal Emergency Management Information System (FEMIS) Data Management Guide for FEMIS Version 1.4.6

    Energy Technology Data Exchange (ETDEWEB)

    Angel, L.K.; Bower, J.C.; Burnett, R.A.; Downing, T.R.; Fangman, P.M.; Hoza, M.; Johnson, D.M.; Johnson, S.M.; Loveall, R.M.; Millard, W.D.; Schulze, S.A.; Wood, B.M.

    1999-06-29

    The Federal Emergency Management Information System (FEMIS) is an emergency management planning and response tool that was developed by the Pacific Northwest National Laboratory (PNNL) under the direction of the U.S. Army Chemical Biological Defense Command. The FEMIS System Administration Guide provides information necessary for the system administrator to maintain the FEMIS system. The FEMIS system is designed for a single Chemical Stockpile Emergency Preparedness Program (CSEPP) site that has multiple Emergency Operations Centers (EOCs). Each EOC has personal computers (PCs) that emergency planners and operations personnel use to do their jobs. These PCs are corrected via a local area network (LAN) to servers that provide EOC-wide services. Each EOC is interconnected to other EOCs via a Wide Area Network (WAN). Thus, FEMIS is an integrated software product that resides on client/server computer architecture. The main body of FEMIS software, referred to as the FEMIS Application Software, resides on the PC client(s) and is directly accessible to emergency management personnel. The remainder of the FEMIS software, referred to as the FEMIS Support Software, resides on the UNIX server. The Support Software provides the communication data distribution and notification functionality necessary to operate FEMIS in a networked, client/server environment.

  12. Improving the Performance of CPU Architectures by Reducing the Operating System Overhead (Extended Version

    Directory of Open Access Journals (Sweden)

    Zagan Ionel

    2016-07-01

    Full Text Available The predictable CPU architectures that run hard real-time tasks must be executed with isolation in order to provide a timing-analyzable execution for real-time systems. The major problems for real-time operating systems are determined by an excessive jitter, introduced mainly through task switching. This can alter deadline requirements, and, consequently, the predictability of hard real-time tasks. New requirements also arise for a real-time operating system used in mixed-criticality systems, when the executions of hard real-time applications require timing predictability. The present article discusses several solutions to improve the performance of CPU architectures and eventually overcome the Operating Systems overhead inconveniences. This paper focuses on the innovative CPU implementation named nMPRA-MT, designed for small real-time applications. This implementation uses the replication and remapping techniques for the program counter, general purpose registers and pipeline registers, enabling multiple threads to share a single pipeline assembly line. In order to increase predictability, the proposed architecture partially removes the hazard situation at the expense of larger execution latency per one instruction.

  13. Commercial Building Energy Asset Score System: Program Overview and Technical Protocol (Version 1.0)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Na; Gorrissen, Willy J.

    2013-01-11

    The U.S. Department of Energy (DOE) is developing a national voluntary energy asset score system that includes an energy asset score tool to help building owners evaluate their buildings with respect to the score system. The goal of the energy asset score system is to facilitate cost-effective investment in energy efficiency improvements of commercial buildings. The system will allow building owners and managers to compare their building infrastructure against peers and track building upgrade progress over time. The system can also help other building stakeholders (e.g., building operators, tenants, financiers, and appraisers) understand the relative efficiency of different buildings in a way that is independent from their operations and occupancy. This report outlines the technical protocol used to generate the energy asset score, explains the scoring methodology, and provides additional details regarding the energy asset score tool. This report also describes alternative methods that were considered prior to developing the current approach. Finally, this report describes a few features of the program where alternative approaches are still under evaluation.

  14. Fuel Cell Power Model Version 2: Startup Guide, System Designs, and Case Studies. Modeling Electricity, Heat, and Hydrogen Generation from Fuel Cell-Based Distributed Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Steward, D.; Penev, M.; Saur, G.; Becker, W.; Zuboy, J.

    2013-06-01

    This guide helps users get started with the U.S. Department of Energy/National Renewable Energy Laboratory Fuel Cell Power (FCPower) Model Version 2, which is a Microsoft Excel workbook that analyzes the technical and economic aspects of high-temperature fuel cell-based distributed energy systems with the aim of providing consistent, transparent, comparable results. This type of energy system would provide onsite-generated heat and electricity to large end users such as hospitals and office complexes. The hydrogen produced could be used for fueling vehicles or stored for later conversion to electricity.

  15. Data management plan for the Oak Ridge Environmental Information System, Version 1. 1

    Energy Technology Data Exchange (ETDEWEB)

    1992-08-04

    The Data Management Plan (DMP) describes the data management objectives, system components, data base structure and contents, system maintenance, data processing, and user interface for the prototype phase of the Oak Ridge Environmental Information System (OREIS). The major goals of OREIS data management are to compile data of known quality, to maintain the integrity of the data base, and to provide data to users. The DMP defines the requirements, describes the responsibilities, and references the procedures for meeting the data management objectives. Emphasis is on management of measurement data and the associated metadata used to support its proper interpretation and legal defensibility. The DMP covers transmittal, processing, storage, and data access activities associated with OREIS. The OREIS data dictionary is provided as an appendix.

  16. Federal Emergency Management Information System (FEMIS) Data Management Guide Version 1.3

    Energy Technology Data Exchange (ETDEWEB)

    Burnett, R.A.; Downing, T.R.; Gaustad, K.L.; Hoza, M.; Johnson, S.M.; Loveall, R.M.; Millard, W.D.; Winters, C.; Wood, B.M.

    1996-12-01

    FEMIS is an emergency management planning and analysis tool that is being developed under the direction of the US Army Chemical and Biological Defense Command. FEMIS is designed to help civilian emergency management personnel to plan for and support their responses to a chemical-releasing event at a military chemical stockpile. This guide provides the background as well as the operations and procedures needed to generate and maintain the data resources in the system. Database administrators, system administrators, and general users can use this guide to manage the datafiles and database. This document provides a description of the relational and spatial information present in FEMIS. It describes how the data was assembled, loaded, and managed while the system is in operation.

  17. Data management plan for the Oak Ridge Environmental Information System, Version 1.1

    International Nuclear Information System (INIS)

    1992-01-01

    The Data Management Plan (DMP) describes the data management objectives, system components, data base structure and contents, system maintenance, data processing, and user interface for the prototype phase of the Oak Ridge Environmental Information System (OREIS). The major goals of OREIS data management are to compile data of known quality, to maintain the integrity of the data base, and to provide data to users. The DMP defines the requirements, describes the responsibilities, and references the procedures for meeting the data management objectives. Emphasis is on management of measurement data and the associated metadata used to support its proper interpretation and legal defensibility. The DMP covers transmittal, processing, storage, and data access activities associated with OREIS. The OREIS data dictionary is provided as an appendix

  18. Current job situation of the alumni from IBS Groningen -2017

    NARCIS (Netherlands)

    Liefers, Jan

    2017-01-01

    Our main question is: what is the current job situation of the alumni from IBS Groningen? The sub questions are: •How many students graduated in the various years? •What are the most popular jobs? •Where do alumni work and what is the career path? •What is their highest degree? •What companies

  19. Al-Shāṭibīs sufismekritik:

    DEFF Research Database (Denmark)

    Riexinger, Martin Thomas

    2016-01-01

    The faqīh (Islamic legal scholar) al-Shāṭibī (d. 1388) from Granada is primarily known for his innovative approach within the field of legal theory (uṣūl al-fiqh). However, he dedicated much attention to the criticism of sufism. But like other Islamic scholars who opposed Sufism he did...

  20. Travel Tips Help IBS Sufferers Enjoy Their Vacations

    Science.gov (United States)

    ... can feel more in control when traveling." IFFGD's travel tips include: Allow enough time in the morning to get to the airport ... Heartache 2004-0929 Norton Honored 2004-0525 IBS Travel Tips ... Real World 2001-1119 Heartburn or Heart Attack Commentary ...

  1. El estudio de la Fauna Ibérica

    Directory of Open Access Journals (Sweden)

    Ramos Sánchez, María Ángeles

    2007-10-01

    Full Text Available Since the beginning in 1989, Fauna Ibérica has promoted coordinated research in Taxonomy bringing together more than 100 Spanish and non-Spanish experts. The programme supported by CSIC Presidency is lead by Museo Nacional de Ciencias Naturales. As a result, 30 Fauna Ibérica monographs has been published in addition to a year average of 50-60 scientific papers describing more than 50 new species per year. IBERFAUNA, the Data Bank of the Spanish Fauna, has been created including 38.000 out of the 61.000 species estimated to live in the Iberian Peninsula and Balearic Islands. This area is confirmed as one of the most biodiverse of the European Union with more than 50 % of the European species and more than 50 % of its endemics. Among future plans, a more stable organization is proposed in order to: maintaining dichotomy paper/digital publications, increasing interactivity among taxonomists and training, developing cyber-tools to facilitate public access to the information and increasing the strength of Fauna Ibérica through collaboration with other international initiatives and other areas of knowledge.Desde su inicio en 1989, Fauna Ibérica ha impulsado la investigación coordinada de más de 100 taxónomos españoles y extranjeros. El programa, apoyado por la Presidencia del CSIC, está dirigido por el Museo Nacional de Ciencias Naturales. Como resultado, se han publicado 30 monografías de la serie Fauna Ibérica, y un promedio anual de 50-60 artículos científicos que describen más de 50 nuevas especies por año. Se ha creado el Banco de Datos, IBERFAUNA, que cuenta ya con 38.000 de las aproximadamente 61.000 especies que habitan en la Península Ibérica y Baleares. Se confirma como una de las regiones más ricas en biodiversidad de la Unión Europea, con más del 50 % de las especies y más de un 50 % de sus endemismos. Entre los planes de futuro, se propone una estructura estable para Fauna Ibérica, que mantenga la dicotomía soporte

  2. Version 2 of RSXMULTI

    International Nuclear Information System (INIS)

    Heinicke, P.; Berg, D.; Constanta-Fanourakis, P.; Quigg, E.K.

    1985-01-01

    MULTI is a general purpose, high speed, high energy physics interface to data acquisition and data investigation system that runs on PDP-11 and VAX architecture. This paper describes the latest version of MULTI, which runs under RSX-11M version 4.1 and supports a modular approach to the separate tasks that interface to it, allowing the same system to be used in single CPU test beam experiments as well as multiple interconnected CPU, large scale experiments. MULTI uses CAMAC (IEE-583) for control and monitoring of an experiment, and is written in FORTRAN-77 and assembler. The design of this version, which simplified the interface between tasks, and eliminated the need for a hard to maintain homegrown I/O system is also discussed

  3. Study of Large Data Resources for Multilingual Training and System Porting (Pub Version, Open Access)

    Science.gov (United States)

    2016-05-03

    extraction trained on a large database corpus – English Fisher. Although the performance of ported monolingual system would be worse in comparison...Language TE LI HA LA ZU LLP hours 8.6 9.6 7.9 8.1 8.4 LM sentences 11935 10743 9861 11577 10644 LM words 68175 83157 93131 93328 60832 dictionary 14505

  4. Aircraft scanner data availability via the version 0 Information Management System

    Science.gov (United States)

    Mah, G. R.

    1995-01-01

    As part of the Earth Observing System Data and Information System (EOSDIS) development, NASA and other government agencies have developed an operational prototype of the Information Management System (IMS). The IMS provides access to the data archived at the Distributed Active Archive Centers (DAAC's) that allows users to search through metadata describing the (image) data. Criteria based on sensor name or type, date and time, and geographic location are used to search the archive. Graphical representations of coverage and browse images are available to further refine a user's selection. previously, the EROS Data Center (EDC) DAAC had identified the Advanced SOlid-state Array Spectrometer (ASAS), Airborne Visible and infrared Imaging Spectrometer (AVIRIS), NS-001, and Thermal Infrared Multispectral Scanner (TIMS) as precursor data sets similar to those the DAAC will handle in the Earth Observing System era. Currently, the EDC DAAC staff, in cooperation with NASA, has transcribed TIMS, NS-001, and Thematic Mapper Simulation (TMS) data from Ames Research Center and also TIMS data from Stennis Space Center. During the transcription process, the IMS metadata and browse images were created to populate the inventory at the EDC DAAC. These data sets are now available in the IMS and may be requested from the any of the DAAC's via the IMS.

  5. System administrator`s guide to CDPS. Version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    Didier, B.T.; Portwood, M.H.

    1994-05-01

    The System Administrator`s Guide to CDPS is intended for those responsible for setting up and maintaining the hardware and software of a Common Mapping Standard (CMS) Date Production System (CDPS) installation. This guide assists the system administrator in performing typical administrative functions. It is not intended to replace the Ultrix Documentation Set that should be available for a DCPS installation. The Ultrix Documentation Set will be required to provide details on referenced Ultrix commands as well as procedures for performing Ultrix maintenance functions. There are six major sections in this guide. Section 1 introduces the system administrator to CDPS and describes the assumptions that are made by this guide. Section 2 describes the CDPS platform configuration. Section 3 describes the platform preparation that is required to install the CDPS software. Section 4 describes the CPS software and its installation procedures. Section 5 describes the CDS software and its installation procedures. Section 6 describes various operation and maintenance procedures. Four appendices are also provided. Appendix A contains a list of used acronyms. Appendix B provides a terse description of common Ultrix commands that are used in administrative functions. Appendix C provides sample CPS and CDS configuration files. Appendix D provides a required list and a recommended list of Ultrix software subsets for installation on a CDPS platform.

  6. Risk-Based Confidentiality Requirements Specification for Outsourced IT Systems (Extended Version)

    NARCIS (Netherlands)

    Morali, A.; Wieringa, Roelf J.

    2010-01-01

    Today, companies are required to be in control of their IT assets, and to provide proof of this in the form of independent IT audit reports. However, many companies have outsourced various parts of their IT systems to other companies, which potentially threatens the control they have of their IT

  7. A Spanish version for the new ERA-EDTA coding system for primary renal disease

    Directory of Open Access Journals (Sweden)

    Óscar Zurriaga

    2015-07-01

    Conclusions: Translation and adaptation into Spanish represent an improvement that will help to introduce and use the new coding system for PKD, as it can help reducing the time devoted to coding and also the period of adaptation of health workers to the new codes.

  8. An Optimized Version of a New Absolute Linear Encoder Dedicated to Intelligent Transportation Systems

    DEFF Research Database (Denmark)

    Argeseanu, Alin; Ritchie, Ewen; Leban, Krisztina Monika

    2009-01-01

    made in the coding algorithm, in the ruler topology and in the dedicated software. The optimized ALE is a robust device able to work in industrial environment, with a high level of vibrations. By this reason it is ideal for the transport system control in automating manufacturing processes, intelligent...

  9. Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®)—Patient Version

    Science.gov (United States)

    Childhood central nervous system (CNS) germ cell tumors form from germ cells (a type of cell that forms as a fetus develops and later becomes sperm in the testicles or eggs in the ovaries). Learn about the signs, tests to diagnose, and treatment of pediatric germ cell tumors in the brain in this expert-reviewed summary.

  10. NetWeaver for EMDS user guide (version 1.1): a knowledge base development system.

    Science.gov (United States)

    Keith M. Reynolds

    1999-01-01

    The guide describes use of the NetWeaver knowledge base development system. Knowledge representation in NetWeaver is based on object-oriented fuzzy-logic networks that offer several significant advantages over the more traditional rulebased representation. Compared to rule-based knowledge bases, NetWeaver knowledge bases are easier to build, test, and maintain because...

  11. Holdup Measurement System II (HMSII): Version 2.1. User's guide and software documentation

    International Nuclear Information System (INIS)

    Smith, S.E.

    1995-01-01

    The Holdup Measurement System II (HMSII) software is a database management package for doing Holdup Measurements. It is based on the generalized geometry holdup (GGH) methodology taught in the US Department of Energy Safeguards Technology Training Program, ''Nondestructive Assay of Special Nuclear Materials Holdup.'' This program was developed and taught by Los Alamos National Laboratory (LANL). The HMSII was developed as a joint effort between LANL and the Oak Ridge Y-12 Plant, managed for the US Department of Energy by Lockheed Martin Energy Systems, Inc. The system is designed specifically for use with three types of Multichannel Analyzer (MCA): a Davidson Portable MultiChannel Analyzer (MCA); a EG ampersand G Ortec MicroNOMAD (μNOMAD); or a new Miniature Modular MultiChannel Analyzer (M 3 CA) under development at LANL. It is also designed assuming a 512 channel spectrum from a low resolution (e.g., NaI) detector measuring Uranium or Plutonium. Another important hardware component of the system is a portable bar code reader (also called a DataLogger or Trakker), by Intermec Corporation. The 944X series and the JANUS 2OXX series readers are compatible models with the HMSII. The JANUS series is a bar code reader which is also a 386 compatible palmtop PC with MS-DOS 5.0 built-in. Both series readers are programmable and control all the aspects of field holdup data collection from the MCAs

  12. BIOACCUMULATION AND AQUATIC SYSTEM SIMULATOR (BASS) USER'S MANUAL BETA TEST VERSION 2.1

    Science.gov (United States)

    BASS (Bioaccumulation and Aquatic System Simulator) is a Fortran 95 simulation program that predicts the population and bioaccumulation dynamics of age-structured fish assemblages that are exposed to hydrophobic organic pollutants and class B and borderline metals that complex wi...

  13. Federal Emergency Management Information System (FEMIS) Data Management Guide for FEMIS Version 1.5

    Energy Technology Data Exchange (ETDEWEB)

    Bower, John C.(BATTELLE (PACIFIC NW LAB)); Burnett, Robert A.(BATTELLE (PACIFIC NW LAB)); Carter, Richard J.(BATTELLE (PACIFIC NW LAB)); Holter, Nancy A.(BATTELLE (PACIFIC NW LAB)); Hoza, Mark (BATTELLE (PACIFIC NW LAB)); Johnson, Daniel M.(BATTELLE (PACIFIC NW LAB)); Johnson, Ranata L.(BATTELLE (PACIFIC NW LAB)); Johnson, Sharon M.(BATTELLE (PACIFIC NW LAB)); Loveall, Robert M.(BATTELLE (PACIFIC NW LAB)); Schulze, Stacy A.(BATTELLE (PACIFIC NW LAB)); Stephan, Alex J.(BATTELLE (PACIFIC NW LAB)); Wood, Blanche M.(BATTELLE (PACIFIC NW LAB))

    2001-12-01

    The Federal Emergency Management System (FEMIS) is an emergency management planning and response tool. The FEMIS Data Management Guide provides the information needed to manage the data used to support the administrative, user-environment, database management, and operational capabilities of FEMIS.

  14. Efficacy of the Social Skills Improvement System Classwide Intervention Program (SSIS-CIP) Primary Version

    Science.gov (United States)

    DiPerna, James Clyde; Lei, Puiwa; Bellinger, Jillian; Cheng, Weiyi

    2015-01-01

    A multisite cluster randomized trial was conducted to examine the effects of the Social Skills Improvement System Classwide Intervention Program (SSIS-CIP; Elliott & Gresham, 2007) on students' classroom social behavior. The final sample included 432 students across 38 second grade classrooms. Social skills and problem behaviors were measured…

  15. Hydrogen Macro System Model User Guide, Version 1.2.1

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, M.; Diakov, V.; Sa, T.; Goldsby, M.; Genung, K.; Hoseley, R.; Smith, A.; Yuzugullu, E.

    2009-07-01

    The Hydrogen Macro System Model (MSM) is a simulation tool that links existing and emerging hydrogen-related models to perform rapid, cross-cutting analysis. It allows analysis of the economics, primary energy-source requirements, and emissions of hydrogen production and delivery pathways.

  16. Systems analysis programs for hands-on integrated reliability evaluations (SAPHIRE) version 5.0, technical reference manual

    International Nuclear Information System (INIS)

    Russell, K.D.; Atwood, C.L.; Galyean, W.J.; Sattison, M.B.; Rasmuson, D.M.

    1994-07-01

    The Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE) refers to a set of several microcomputer programs that were developed to create and analyze probabilistic risk assessments (PRAs), primarily for nuclear power plants. This volume provides information on the principles used in the construction and operation of Version 5.0 of the Integrated Reliability and Risk Analysis System (IRRAS) and the System Analysis and Risk Assessment (SARA) system. It summarizes the fundamental mathematical concepts of sets and logic, fault trees, and probability. This volume then describes the algorithms that these programs use to construct a fault tree and to obtain the minimal cut sets. It gives the formulas used to obtain the probability of the top event from the minimal cut sets, and the formulas for probabilities that are appropriate under various assumptions concerning repairability and mission time. It defines the measures of basic event importance that these programs can calculate. This volume gives an overview of uncertainty analysis using simple Monte Carlo sampling or Latin Hypercube sampling, and states the algorithms used by these programs to generate random basic event probabilities from various distributions. Further references are given, and a detailed example of the reduction and quantification of a simple fault tree is provided in an appendix

  17. Computer System for Monitoring Environmental Campaigns. User's Guide. Version 1.0

    International Nuclear Information System (INIS)

    Bailador, M.A.; Barcala, M.; Blanco, F.; Gonzalez, C.; Perez, J. M.; Sanchez, A.; Sanchez, E.; Willmot, C.

    2012-01-01

    CIEMAT has an environmental mobile unit to carry out the execution of environmental measures at diverse environments. During the last years, this unit has been involved in changes relative to its instrumentation, being necessary to developed an informatics system, SiSCA Informatics System for the monitoring of environmental campaigns, that is able to: Acquiring in a synchronized way the data from the environmental mobile unit instruments. Showing in a georrefential way these data by means of GIS technology. Transmitting in a secure way and in real time the data to a centralized data base repository This document is the user guide that picks up all the necessary information to use SiSCA when UMA environmental campaigns are carrying out. (Author)

  18. Disposal Systems Evaluation Framework (DSEF) Version 1.0 - Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Sutton, Mark [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Blink, James A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Fratoni, Massimiliano [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Greenberg, Harris R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Halsey, William G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wolery, Thomas J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-06-03

    The Disposal Systems Evaluation Framework (DSEF) is being developed at Lawrence Livermore National Laboratory to formalize the development and documentation of repository conceptual design options for each waste form and environment combination. This report summarizes current status and plans for the remainder of FY11 and for FY12. This progress report defines the architecture and interface parameters of the DSEF Excel workbook, which contains worksheets that link to each other to provide input and document output from external codes such that concise comparisons between fuel cycles, disposal environments, repository designs and engineered barrier system materials can be performed. Collaborations between other Used Fuel Disposition Campaign work packages and US Department of Energy / Nuclear Energy campaigns are clearly identified. File naming and configuration management is recommended to allow automated abstraction of data from multiple DSEF runs.

  19. Thermal Insulation System Analysis Tool (TISTool) User's Manual. Version 1.0.0

    Science.gov (United States)

    Johnson, Wesley; Fesmire, James; Leucht, Kurt; Demko, Jonathan

    2010-01-01

    The Thermal Insulation System Analysis Tool (TISTool) was developed starting in 2004 by Jonathan Demko and James Fesmire. The first edition was written in Excel and Visual BasIc as macros. It included the basic shapes such as a flat plate, cylinder, dished head, and sphere. The data was from several KSC tests that were already in the public literature realm as well as data from NIST and other highly respectable sources. More recently, the tool has been updated with more test data from the Cryogenics Test Laboratory and the tank shape was added. Additionally, the tool was converted to FORTRAN 95 to allow for easier distribution of the material and tool. This document reviews the user instructions for the operation of this system.

  20. IDC Re-Engineering Phase 2 System Requirements Document Version 1.4

    Energy Technology Data Exchange (ETDEWEB)

    Harris, James M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Burns, John F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Satpathi, Meara Allena [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-01-01

    This System Requirements Document (SRD) defines waveform data processing requirements for the International Data Centre (IDC) of the Comprehensive Nuclear Test Ban Treaty Organization (CTBTO). The IDC applies, on a routine basis, automatic processing methods and interactive analysis to raw International Monitoring System (IMS) data in order to produce, archive, and distribute standard IDC products on behalf of all States Parties. The routine processing includes characterization of events with the objective of screening out events considered to be consistent with natural phenomena or non-nuclear, man-made phenomena. This document does not address requirements concerning acquisition, processing and analysis of radionuclide data, but includes requirements for the dissemination of radionuclide data and products.

  1. NCTPlan. The new PC version of MacNCTPlan improvements and validation of the treatment planning system

    International Nuclear Information System (INIS)

    Gonzalez, S.J.; Santa Cruz, Gustavo A.; Yam, C.S.

    2003-01-01

    Full text: The treatment planning system that has been used routinely in phase-I clinical trials of BNCT at Harvard/MIT consists of the MacNCTPlan interactive planning software coupled to the MCNP 4B Monte Carlo radiation transport code. The physical and mathematical principles of MacNCTPlan as well as its architecture, operation and application have been previously described elsewhere. The use of this software in clinical trials together with a detailed analysis of the code led to the identification of some limitations and deficiencies. The motivation for this PC version, Neutron Capture Therapy Planning, relies basically in two major reasons: the need to integrate the different steps for making a plan and the need to improve some features of the Macintosh version. NCTPlan aims to reproduce all the features and capabilities present in the Macintosh version. Working on this, some deficiencies were corrected and several changes in the interface were performed in order to provide a more friendly and reliable program. Among the changes intended to facilitate the treatment planning process, the most important are the integration of the auxiliary program MPREP to NCTPlan and a great improvement in the visualization of isodose contours. NCTPlan has the ability to show the isodose distributions superimposed on two orthogonal planes of the CT volume, these planes being updated in real time as the orientation of the planes is changed. The major modifications to the mathematical algorithms concerned the material assignment in the geometric model, dose distribution calculations and three-dimensional dose-volume histogram (DVH) derivation. Therefore, NCTPlan provides a user-friendly interface thanks to the integration of the different steps involved in treatment planning. Complete control of the MCNP radiation transport code is under study. Cross-validation of NCTPlan against reference calculations made apparent the improvements performed on the mathematical algorithms

  2. Air Force Systems Engineering Assessment Model (AF SEAM) Management Guide, Version 2

    Science.gov (United States)

    2010-09-21

    gleaned from experienced professionals who assisted with the model’s development. Examples of the references used include the following: • ISO /IEC...Defense Acquisition Guidebook, Chapter 4 • AFI 63-1201, Life Cycle Systems Engineering • IEEE/EIA 12207 , Software Life Cycle Processes • Air...Selection criteria Reference Material: IEEE/EIA 12207 , MIL-HDBK-514 Other Considerations: Modeling, simulation and analysis techniques can be

  3. Validation Test Report for the Automated Optical Processing System (AOPS) Version 4.12

    Science.gov (United States)

    2015-09-03

    Sensor (SeaWiFS), Moderate Resolution Imaging Spectrometers ( MODIS on Aqua), and Medium Resolution Imaging Spectrometer (MERIS). This VTR documents...the MOBY site. 3.2.1 Image to Image Comparison The AOPS v4.12 upgrades are detailed in Section 2 System Description. Figure 5 shows the MODIS ...bottom images were processed with AOPS v4.12; MODIS imagery on the left and VIIRS on the right. The most significant change in the VIIRS imagery is

  4. Report on the French power system. Version 1.0. Country profile

    Energy Technology Data Exchange (ETDEWEB)

    Kleiner, Mara Marthe (ed.)

    2015-02-15

    France is currently reshaping its energy and climate policy, with a commitment to reduce the share of nuclear energy in the power mix, together with ambitious goals for the development of renewables and energy efficiency. This French energy transition paradigm (transition energetique) is serving as a common ground for stronger energy cooperation with Germany. This report describes the status quo of the French power system and provides important numbers.

  5. A Scalable Version of the Navy Operational Global Atmospheric Prediction System Spectral Forecast Model

    Directory of Open Access Journals (Sweden)

    Thomas E. Rosmond

    2000-01-01

    Full Text Available The Navy Operational Global Atmospheric Prediction System (NOGAPS includes a state-of-the-art spectral forecast model similar to models run at several major operational numerical weather prediction (NWP centers around the world. The model, developed by the Naval Research Laboratory (NRL in Monterey, California, has run operational at the Fleet Numerical Meteorological and Oceanographic Center (FNMOC since 1982, and most recently is being run on a Cray C90 in a multi-tasked configuration. Typically the multi-tasked code runs on 10 to 15 processors with overall parallel efficiency of about 90%. resolution is T159L30, but other operational and research applications run at significantly lower resolutions. A scalable NOGAPS forecast model has been developed by NRL in anticipation of a FNMOC C90 replacement in about 2001, as well as for current NOGAPS research requirements to run on DOD High-Performance Computing (HPC scalable systems. The model is designed to run with message passing (MPI. Model design criteria include bit reproducibility for different processor numbers and reasonably efficient performance on fully shared memory, distributed memory, and distributed shared memory systems for a wide range of model resolutions. Results for a wide range of processor numbers, model resolutions, and different vendor architectures are presented. Single node performance has been disappointing on RISC based systems, at least compared to vector processor performance. This is a common complaint, and will require careful re-examination of traditional numerical weather prediction (NWP model software design and data organization to fully exploit future scalable architectures.

  6. Uncorrelated Encounter Model of the National Airspace System, Version 2.0

    Science.gov (United States)

    2013-08-19

    can exist to certify avoidance systems for operational use. Evaluations typically include flight tests, operational impact studies, and simulation of...appropriate for large-scale air traffic impact studies— for example, examination of sector loading or conflict rates. The focus here includes two types of...between two IFR aircraft in oceanic airspace. The reason for this is that one cannot observe encounters of sufficient fidelity in the available data

  7. Automated Procurement System (APS): Project management plan (DS-03), version 1.2

    Science.gov (United States)

    Murphy, Diane R.

    1994-01-01

    The National Aeronautics and Space Administration (NASA) Marshall Space Flight Center (MSFC) is implementing an Automated Procurement System (APS) to streamline its business activities that are used to procure goods and services. This Project Management Plan (PMP) is the governing document throughout the implementation process and is identified as the APS Project Management Plan (DS-03). At this point in time, the project plan includes the schedules and tasks necessary to proceed through implementation. Since the basis of APS is an existing COTS system, the implementation process is revised from the standard SDLC. The purpose of the PMP is to provide the framework for the implementation process. It discusses the roles and responsibilities of the NASA project staff, the functions to be performed by the APS Development Contractor (PAI), and the support required of the NASA computer support contractor (CSC). To be successful, these three organizations must work together as a team, working towards the goals established in this Project Plan. The Project Plan includes a description of the proposed system, describes the work to be done, establishes a schedule of deliverables, and discusses the major standards and procedures to be followed.

  8. Systems Biology Graphical Notation: Process Description language Level 1 Version 1.3.

    Science.gov (United States)

    Moodie, Stuart; Le Novère, Nicolas; Demir, Emek; Mi, Huaiyu; Villéger, Alice

    2015-09-04

    The Systems Biological Graphical Notation (SBGN) is an international community effort for standardized graphical representations of biological pathways and networks. The goal of SBGN is to provide unambiguous pathway and network maps for readers with different scientific backgrounds as well as to support efficient and accurate exchange of biological knowledge between different research communities, industry, and other players in systems biology. Three SBGN languages, Process Description (PD), Entity Relationship (ER) and Activity Flow (AF), allow for the representation of different aspects of biological and biochemical systems at different levels of detail. The SBGN Process Description language represents biological entities and processes between these entities within a network. SBGN PD focuses on the mechanistic description and temporal dependencies of biological interactions and transformations. The nodes (elements) are split into entity nodes describing, e.g., metabolites, proteins, genes and complexes, and process nodes describing, e.g., reactions and associations. The edges (connections) provide descriptions of relationships (or influences) between the nodes, such as consumption, production, stimulation and inhibition. Among all three languages of SBGN, PD is the closest to metabolic and regulatory pathways in biological literature and textbooks, but its well-defined semantics offer a superior precision in expressing biological knowledge.

  9. Systems Biology Graphical Notation: Activity Flow language Level 1 Version 1.2.

    Science.gov (United States)

    Mi, Huaiyu; Schreiber, Falk; Moodie, Stuart; Czauderna, Tobias; Demir, Emek; Haw, Robin; Luna, Augustin; Le Novère, Nicolas; Sorokin, Anatoly; Villéger, Alice

    2015-09-04

    The Systems Biological Graphical Notation (SBGN) is an international community effort for standardized graphical representations of biological pathways and networks. The goal of SBGN is to provide unambiguous pathway and network maps for readers with different scientific backgrounds as well as to support efficient and accurate exchange of biological knowledge between different research communities, industry, and other players in systems biology. Three SBGN languages, Process Description (PD), Entity Relationship (ER) and Activity Flow (AF), allow for the representation of different aspects of biological and biochemical systems at different levels of detail. The SBGN Activity Flow language represents the influences of activities among various entities within a network. Unlike SBGN PD and ER that focus on the entities and their relationships with others, SBGN AF puts the emphasis on the functions (or activities) performed by the entities, and their effects to the functions of the same or other entities. The nodes (elements) describe the biological activities of the entities, such as protein kinase activity, binding activity or receptor activity, which can be easily mapped to Gene Ontology molecular function terms. The edges (connections) provide descriptions of relationships (or influences) between the activities, e.g., positive influence and negative influence. Among all three languages of SBGN, AF is the closest to signaling pathways in biological literature and textbooks, but its well-defined semantics offer a superior precision in expressing biological knowledge.

  10. Systems Biology Graphical Notation: Entity Relationship language Level 1 Version 2.

    Science.gov (United States)

    Sorokin, Anatoly; Le Novère, Nicolas; Luna, Augustin; Czauderna, Tobias; Demir, Emek; Haw, Robin; Mi, Huaiyu; Moodie, Stuart; Schreiber, Falk; Villéger, Alice

    2015-09-04

    The Systems Biological Graphical Notation (SBGN) is an international community effort for standardized graphical representations of biological pathways and networks. The goal of SBGN is to provide unambiguous pathway and network maps for readers with different scientific backgrounds as well as to support efficient and accurate exchange of biological knowledge between different research communities, industry, and other players in systems biology. Three SBGN languages, Process Description (PD), Entity Relationship (ER) and Activity Flow (AF), allow for the representation of different aspects of biological and biochemical systems at different levels of detail. The SBGN Entity Relationship language (ER) represents biological entities and their interactions and relationships within a network. SBGN ER focuses on all potential relationships between entities without considering temporal aspects. The nodes (elements) describe biological entities, such as proteins and complexes. The edges (connections) provide descriptions of interactions and relationships (or influences), e.g., complex formation, stimulation and inhibition. Among all three languages of SBGN, ER is the closest to protein interaction networks in biological literature and textbooks, but its well-defined semantics offer a superior precision in expressing biological knowledge.

  11. Operators Manual and Technical Reference for the Z-Beamlet Phase Modulation Failsafe System: Version 1.

    Energy Technology Data Exchange (ETDEWEB)

    Armstrong, Darrell J.

    2014-09-01

    The need for pulse energies exceeding 4 kJ and pulse lengths [?] 2 ns in Sandia's Z-Beamlet laser (ZBL) requires that the single-frequency spectrum of its fiber-laser master oscillator be converted to a phase modulated spectrum with a modulation in dex [?] 5. Because accidental injection of single-frequency light into ZBL could result i n damage to optical materials from transverse stimulated Brillouin scattering, the presence of phase modulated (PM) light must be monitored by a reliable failsafe system that can stop a las er shot within of a few 10's of ns following a failure of the PM system. This requirement is met by combining optical heterodyne detection with high-speed electronics to indicate the pres ence or absence of phase modulated light. The transition time for the failsafe signal resultin g from a sudden failure using this technique is approximately 35 ns. This is sufficiently short to safely stop a single-frequency laser pulse from leaving ZBL's regenerative amplifier with a n approximately 35 ns margin of safety. This manual and technical reference contains detai led instructions for daily use of the PM failsafe system and provides enough additional informat ion for its maintenance and repair.

  12. WASTES II: Waste System Transportation and Economic Simulation. Version II. User's guide

    International Nuclear Information System (INIS)

    Shay, M.R.; Buxbaum, M.E.

    1986-02-01

    The WASTES II model was developed to provide detailed analyses beyond the capabilities of other available models. WASTES uses discrete event simulation techniques to model the generation of commercial spent nuclear fuel, the buildup of spent fuel inventories within the system, and the transportation requirements for the movement of radioactive waste throughout the system. The model is written in FORTRAN 77 as an extension to the SLAM commercial simulation language package. In addition to the pool storage and dry storage located at the reactors, the WASTES model provides a choice of up to ten other storage facilities of four different types. The simulation performed by WASTES may be controlled by a combination of source- and/or destination-controlled transfers that are requested by the code user. The user supplies shipping cask characteristics for truck or rail shipment casks. As part of the facility description, the user specifies which casks the facility can use. Shipments within the system can be user specified to occur optimally, or proximally. Optimized shipping can be used when exactly two destination facilities of the same facility type are open for receipt of fuel. Optimized shipping selects source/destination pairs so that the total shipping distance or total shipping costs in a given year are minimized when both facilities are fully utilized. Proximity shipping sequentially fills the closest facility to the source according to the shipment priorities without regard for the total annual shipments. This results in sub-optimal routing of waste material but can be used to approximate an optimal shipping strategy when more than two facilities of the same type are available to receive waste. WASTES is currently able to analyze each of the commercial spent fuel logistics scenarios specified in the 1985 DOE Mission Plan

  13. PC-BEIS: a personal computer version of the biogenic emissions inventory system

    International Nuclear Information System (INIS)

    Pierce, T.E.; Waldruff, P.S.

    1991-01-01

    The US Environmental Protection Agency's Biogenic Emissions Inventory System (BEIS) has been adapted for use on IBM-compatible personal computers (PCs). PC-BEIS estimates hourly emissions of isoprene, α-pinene, other monoterpenes, and unidentified hydrocarbons for any county in the contiguous United States. To run the program, users must provide hourly data on ambient temperature, relative humidity, wind speed, cloud cover, and a code that identifies the particular county. This paper provides an overview of the method used to calculate biogenic emissions, shows an example application, and gives information on how to obtain a copy of the program

  14. GRESS [Gradient Enhanced Software System] Version 0.0 user's manual

    International Nuclear Information System (INIS)

    Horwedel, J.E.; Worley, B.A.; Oblow, E.M.; Pin, F.G.; Wright, R.Q.

    1988-10-01

    The primary objective of this manual is to provide a description of the Gradient Enhanced Software System (GRESS) and to explain how to use GRESS to enhance FORTRAN 77 models for gradient calculation. The use of the Extended Arithmetic Processor (EXAP) as the precompiler for GRESS is presented. A complete description of how to enhance a source code for forward propagation of derivatives using the calculus chain rule is provided. On option, EXAP can be used to generate derivatives and store them on a direct access device for subsequent solution of the numerical adjoint equations. Programming information is also provided to aid in the installation and maintenance of the software

  15. Computer-aided structure elucidation Pt. 3. Extended version of assigner system

    Energy Technology Data Exchange (ETDEWEB)

    Szalontai, G; Csapo, Z; Recsey, Zs [Nehezvegyipari Kutato Intezet, Veszprem (Hungary)

    1982-01-01

    Computer-aided interpretation of /sup 13/C-NMR, /sup 1/H-NMR and IR spectra of organic molecules (M.W.<=500) has been performed by an artificial intelligence approach. A procedure for the joint /sup 13/C-NMR - /sup 1/H-NMR - IR spectrum interpretation is outlined. Possible ways of finding acceptable greater fragments on the basis of /sup 1/H-NMR - /sup 13/C-NMR data and of /sup 13/C-NMR data alone are also described. Detailed examples are given to demonstrate the capability of the system.

  16. Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Zhonghan Yang

    2012-01-01

    Full Text Available Irritable bowel syndrome (IBS is a functional bowel disorder and the etiology is not well understood. Currently there is no cure for IBS and no existing medication induces symptom relief in all patients. IBS-20 is a 20-herb Chinese medicinal formula that offers beneficial effects in patients with IBS; however, the underlying mechanisms are largely unknown. This study showed that IBS-20 potently inhibited LPS- or IFNΓ-stimulated expression of pro-inflammatory cytokines, as well as classically activated macrophage marker nitric oxide synthase 2. Similarly, IBS-20 or the component herb Coptis chinensis decreased LPS-stimulated pro-inflammatory cytokine secretion from JAWS II dendritic cells. IBS-20 or the component herbs also blocked or attenuated the IFNΓ-induced drop in transepithelial electric resistance, an index of permeability, in fully differentiated Caco-2 monolayer. Finally, the up-regulation of key inflammatory cytokines in inflamed colon from TNBS-treated mice was suppressed significantly by orally administrated IBS-20, including IFNΓ and IL-12p40. These data indicate that the anti-inflammatory activities of IBS-20 may contribute to the beneficial effects of the herbal extract in patients with IBS, providing a potential mechanism of action for IBS-20. In addition, IBS-20 may be a potential therapeutic agent against other Th1-dominant gut pathologies such as inflammatory bowel disease.

  17. Some uncertainty results obtained by the statistical version of the KARATE code system related to core design and safety analysis

    Energy Technology Data Exchange (ETDEWEB)

    Panka, Istvan; Hegyi, Gyoergy; Maraczy, Csaba; Temesvari, Emese [Hungarian Academy of Sciences, Budapest (Hungary). Reactor Analysis Dept.

    2017-11-15

    The best-estimate KARATE code system has been widely used for core design calculations and simulations of slow transients of VVER reactors. Recently there has been an increasing need for assessing the uncertainties of such calculations by propagating the basic input uncertainties of the models through the full calculation chain. In order to determine the uncertainties of quantities of interest during the burnup, the statistical version of the KARATE code system has been elaborated. In the first part of the paper, the main features of the new code system are discussed. The applied statistical method is based on Monte-Carlo sampling of the considered input data taking into account mainly the covariance matrices of the cross sections and/or the technological uncertainties. In the second part of the paper, only the uncertainties of cross sections are considered and an equilibrium cycle related to a VVER-440 type reactor is investigated. The burnup dependence of the uncertainties of some safety related parameters (e.g. critical boron concentration, rod worth, feedback coefficients, assembly-wise radial power and burnup distribution) are discussed and compared to the recently used limits.

  18. The natural defense system and the normative self model [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Philippe Kourilsky

    2016-05-01

    Full Text Available Infectious agents are not the only agressors, and the immune system is not the sole defender of the organism. In an enlarged perspective, the ‘normative self model’ postulates that a ‘natural defense system’ protects man and other complex organisms against the environmental and internal hazards of life, including infections and cancers. It involves multiple error detection and correction mechanisms that confer robustness to the body at all levels of its organization. According to the model, the self relies on a set of physiological norms, and NONself (meaning : Non Obedient to the Norms of the self is anything ‘off-norms’. The natural defense system comprises a set of ‘civil defenses’ (to which all cells in organs and tissues contribute, and a ‘professional army ‘, made of a smaller set of mobile cells. Mobile and non mobile cells differ in their tuning abilities. Tuning extends the recognition capabilities of NONself by the mobile cells, which increase their defensive function. To prevent them to drift, which would compromise self/NONself discrimination, the more plastic mobile cells need to periodically refer to the more stable non mobile cells to keep within physiological standards.

  19. NCCN Guidelines Insights: Central Nervous System Cancers, Version 1.2017.

    Science.gov (United States)

    Nabors, Louis Burt; Portnow, Jana; Ammirati, Mario; Baehring, Joachim; Brem, Henry; Butowski, Nicholas; Fenstermaker, Robert A; Forsyth, Peter; Hattangadi-Gluth, Jona; Holdhoff, Matthias; Howard, Steven; Junck, Larry; Kaley, Thomas; Kumthekar, Priya; Loeffler, Jay S; Moots, Paul L; Mrugala, Maciej M; Nagpal, Seema; Pandey, Manjari; Parney, Ian; Peters, Katherine; Puduvalli, Vinay K; Ragsdale, John; Rockhill, Jason; Rogers, Lisa; Rusthoven, Chad; Shonka, Nicole; Shrieve, Dennis C; Sills, Allen K; Swinnen, Lode J; Tsien, Christina; Weiss, Stephanie; Wen, Patrick Yung; Willmarth, Nicole; Bergman, Mary Anne; Engh, Anita

    2017-11-01

    For many years, the diagnosis and classification of gliomas have been based on histology. Although studies including large populations of patients demonstrated the prognostic value of histologic phenotype, variability in outcomes within histologic groups limited the utility of this system. Nonetheless, histology was the only proven and widely accessible tool available at the time, thus it was used for clinical trial entry criteria, and therefore determined the recommended treatment options. Research to identify molecular changes that underlie glioma progression has led to the discovery of molecular features that have greater diagnostic and prognostic value than histology. Analyses of these molecular markers across populations from randomized clinical trials have shown that some of these markers are also predictive of response to specific types of treatment, which has prompted significant changes to the recommended treatment options for grade III (anaplastic) gliomas. Copyright © 2017 by the National Comprehensive Cancer Network.

  20. The SAS4A/SASSYS-1 Safety Analysis Code System, Version 5

    Energy Technology Data Exchange (ETDEWEB)

    Fanning, T. H. [Argonne National Lab. (ANL), Argonne, IL (United States); Brunett, A. J. [Argonne National Lab. (ANL), Argonne, IL (United States); Sumner, T. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-01-01

    The SAS4A/SASSYS-1 computer code is developed by Argonne National Laboratory for thermal, hydraulic, and neutronic analysis of power and flow transients in liquidmetal- cooled nuclear reactors (LMRs). SAS4A was developed to analyze severe core disruption accidents with coolant boiling and fuel melting and relocation, initiated by a very low probability coincidence of an accident precursor and failure of one or more safety systems. SASSYS-1, originally developed to address loss-of-decay-heat-removal accidents, has evolved into a tool for margin assessment in design basis accident (DBA) analysis and for consequence assessment in beyond-design-basis accident (BDBA) analysis. SAS4A contains detailed, mechanistic models of transient thermal, hydraulic, neutronic, and mechanical phenomena to describe the response of the reactor core, its coolant, fuel elements, and structural members to accident conditions. The core channel models in SAS4A provide the capability to analyze the initial phase of core disruptive accidents, through coolant heat-up and boiling, fuel element failure, and fuel melting and relocation. Originally developed to analyze oxide fuel clad with stainless steel, the models in SAS4A have been extended and specialized to metallic fuel with advanced alloy cladding. SASSYS-1 provides the capability to perform a detailed thermal/hydraulic simulation of the primary and secondary sodium coolant circuits and the balance-ofplant steam/water circuit. These sodium and steam circuit models include component models for heat exchangers, pumps, valves, turbines, and condensers, and thermal/hydraulic models of pipes and plena. SASSYS-1 also contains a plant protection and control system modeling capability, which provides digital representations of reactor, pump, and valve controllers and their response to input signal changes.

  1. Effect of software version and parameter settings on the marginal and internal adaptation of crowns fabricated with the CAD/CAM system

    Directory of Open Access Journals (Sweden)

    Ji Suk SHIM

    2015-10-01

    Full Text Available Objective This study investigated the marginal and internal adaptation of individual dental crowns fabricated using a CAD/CAM system (Sirona’s BlueCam, also evaluating the effect of the software version used, and the specific parameter settings in the adaptation of crowns.Material and Methods Forty digital impressions of a master model previously prepared were acquired using an intraoral scanner and divided into four groups based on the software version and on the spacer settings used. The versions 3.8 and 4.2 of the software were used, and the spacer parameter was set at either 40 μm or 80 μm. The marginal and internal fit of the crowns were measured using the replica technique, which uses a low viscosity silicone material that simulates the thickness of the cement layer. The data were analyzed using a Friedman two-way analysis of variance (ANOVA and paired t-tests with significance level set at p<0.05.Results The two-way ANOVA analysis showed the software version (p<0.05 and the spacer parameter (p<0.05 significantly affected the crown adaptation. The crowns designed with the version 4.2 of the software showed a better fit than those designed with the version 3.8, particularly in the axial wall and in the inner margin. The spacer parameter was more accurately represented in the version 4.2 of the software than in the version 3.8. In addition, the use of the version 4.2 of the software combined with the spacer parameter set at 80 μm showed the least variation. On the other hand, the outer margin was not affected by the variables.Conclusion Compared to the version 3.8 of the software, the version 4.2 can be recommended for the fabrication of well-fitting crown restorations, and for the appropriate regulation of the spacer parameter.

  2. Presentation, calibration and validation of the low-order, DCESS Earth System Model (Version 1

    Directory of Open Access Journals (Sweden)

    J. O. Pepke Pedersen

    2008-11-01

    Full Text Available A new, low-order Earth System Model is described, calibrated and tested against Earth system data. The model features modules for the atmosphere, ocean, ocean sediment, land biosphere and lithosphere and has been designed to simulate global change on time scales of years to millions of years. The atmosphere module considers radiation balance, meridional transport of heat and water vapor between low-mid latitude and high latitude zones, heat and gas exchange with the ocean and sea ice and snow cover. Gases considered are carbon dioxide and methane for all three carbon isotopes, nitrous oxide and oxygen. The ocean module has 100 m vertical resolution, carbonate chemistry and prescribed circulation and mixing. Ocean biogeochemical tracers are phosphate, dissolved oxygen, dissolved inorganic carbon for all three carbon isotopes and alkalinity. Biogenic production of particulate organic matter in the ocean surface layer depends on phosphate availability but with lower efficiency in the high latitude zone, as determined by model fit to ocean data. The calcite to organic carbon rain ratio depends on surface layer temperature. The semi-analytical, ocean sediment module considers calcium carbonate dissolution and oxic and anoxic organic matter remineralisation. The sediment is composed of calcite, non-calcite mineral and reactive organic matter. Sediment porosity profiles are related to sediment composition and a bioturbated layer of 0.1 m thickness is assumed. A sediment segment is ascribed to each ocean layer and segment area stems from observed ocean depth distributions. Sediment burial is calculated from sedimentation velocities at the base of the bioturbated layer. Bioturbation rates and oxic and anoxic remineralisation rates depend on organic carbon rain rates and dissolved oxygen concentrations. The land biosphere module considers leaves, wood, litter and soil. Net primary production depends on atmospheric carbon dioxide concentration and

  3. Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE), Version 5.0. Volume 5, Systems Analysis and Risk Assessment (SARA) tutorial manual

    International Nuclear Information System (INIS)

    Sattison, M.B.; Russell, K.D.; Skinner, N.L.

    1994-07-01

    The Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE) refers to a set of several microcomputer programs that were developed to create and analyze probabilistic risk assessments (PRAs) primarily for nuclear power plants. This volume is the tutorial manual for the Systems Analysis and Risk Assessment (SARA) System Version 5.0, a microcomputer-based system used to analyze the safety issues of a open-quotes familyclose quotes [i.e., a power plant, a manufacturing facility, any facility on which a probabilistic risk assessment (PRA) might be performed]. A series of lessons is provided that guides the user through some basic steps common to most analyses performed with SARA. The example problems presented in the lessons build on one another, and in combination, lead the user through all aspects of SARA sensitivity analysis capabilities

  4. PHITS: Particle and heavy ion transport code system, version 2.23

    International Nuclear Information System (INIS)

    Niita, Koji; Matsuda, Norihiro; Iwamoto, Yosuke; Sato, Tatsuhiko; Nakashima, Hiroshi; Sakamoto, Yukio; Iwase, Hiroshi; Sihver, Lembit

    2010-10-01

    A Particle and Heavy-Ion Transport code System PHITS has been developed under the collaboration of JAEA (Japan Atomic Energy Agency), RIST (Research Organization for Information Science and Technology) and KEK (High Energy Accelerator Research Organization). PHITS can deal with the transport of all particles (nucleons, nuclei, mesons, photons, and electrons) over wide energy ranges, using several nuclear reaction models and nuclear data libraries. Geometrical configuration of the simulation can be set with GG (General Geometry) or CG (Combinatorial Geometry). Various quantities such as heat deposition, track length and production yields can be deduced from the simulation, using implemented estimator functions called 'tally'. The code also has a function to draw 2D and 3D figures of the calculated results as well as the setup geometries, using a code ANGEL. Because of these features, PHITS has been widely used for various purposes such as designs of accelerator shielding, radiation therapy and space exploration. Recently PHITS introduces an event generator for particle transport parts in the low energy region. Thus, PHITS was completely rewritten for the introduction of the event generator for neutron-induced reactions in energy region less than 20 MeV. Furthermore, several new tallis were incorporated for estimation of the relative biological effects. This document provides a manual of the new PHITS. (author)

  5. Applying a complex adaptive system's understanding of health to primary care [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Johannes Bircher

    2016-09-01

    Full Text Available This paper explores the diagnostic and therapeutic potential of a new concept of health. Investigations into the nature of health have led to a new definition that explains health as a complex adaptive system (CAS and is based on five components (a-e. Humans like all biological creatures must satisfactorily respond to (a the demands of life. For this purpose they need (b a biologically given potential (BGP and (c a personally acquired potential (PAP. These properties of individuals are embedded within (d social and (e environmental determinants of health. Between these five components of health there are 10 complex interactions that justify viewing health as a CAS. In each patient, the current state of health as a CAS evolved from the past, will move forward to a new future, and has to be analyzed and treated as an autonomous whole. A diagnostic procedure is suggested as follows: together with the patient, the five components and 10 complex interactions are assessed. This may help patients to better understand their situations and to recognize possible next steps that may be useful in order to evolve toward better health by themselves. In this process mutual trust in the patient-physician interaction is critical. The described approach offers new possibilities for helping patients improve their health prospects.

  6. Multiple system atrophy: genetic risks and alpha-synuclein mutations [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Heather T Whittaker

    2017-11-01

    Full Text Available Multiple system atrophy (MSA is one of the few neurodegenerative disorders where we have a significant understanding of the clinical and pathological manifestations but where the aetiology remains almost completely unknown. Research to overcome this hurdle is gaining momentum through international research collaboration and a series of genetic and molecular discoveries in the last few years, which have advanced our knowledge of this rare synucleinopathy. In MSA, the discovery of α-synuclein pathology and glial cytoplasmic inclusions remain the most significant findings. Families with certain types of α-synuclein mutations develop diseases that mimic MSA, and the spectrum of clinical and pathological features in these families suggests a spectrum of severity, from late-onset Parkinson’s disease to MSA. Nonetheless, controversies persist, such as the role of common α-synuclein variants in MSA and whether this disorder shares a common mechanism of spreading pathology with other protein misfolding neurodegenerative diseases. Here, we review these issues, specifically focusing on α-synuclein mutations.

  7. A Full Slice Test Version of a Tentative Upgraded Readout System for TileCal

    CERN Document Server

    Muschter, S; The ATLAS collaboration; Bohm, C; Eriksson, D; Kavianipour, H; Oreglia, M; Tang, F

    2011-01-01

    The upgrade plans on the ATLAS hadronic calorimeter (TileCal) include the full readout of all data to the counting room. In order to study functional requirements of the future upgraded TileCal readout system we have assembled a minimal TDAQ slice. The aim is to implement a tentative readout chain for TileCal, starting with a newly developed 3-in-1 FE-board from University of Chicago and ending with the storage of triggered data on a PC. Later we will use PMT pulses, amplified and shaped by the 3-in-1 board, as a data source. However, for simplicity we start by using well defined calibration pulses also generated by the 3-in-1 board. The pulses are sampled by a 12 bit ADC, which is connected to an ML605 evaluation board from XILINX. These boards emulate the new on-detector electronics. The ML605 communicates via two 5Gb/s optical links with a Virtex-6 FPGA development board from HighTech Global which emulates the off-detector electronics. The off-detector board is situated in a PC and uses PCIe for readout an...

  8. The Community WRF-Hydro Modeling System Version 4 Updates: Merging Toward Capabilities of the National Water Model

    Science.gov (United States)

    McAllister, M.; Gochis, D.; Dugger, A. L.; Karsten, L. R.; McCreight, J. L.; Pan, L.; Rafieeinasab, A.; Read, L. K.; Sampson, K. M.; Yu, W.

    2017-12-01

    The community WRF-Hydro modeling system is publicly available and provides researchers and operational forecasters a flexible and extensible capability for performing multi-scale, multi-physics options for hydrologic modeling that can be run independent or fully-interactive with the WRF atmospheric model. The core WRF-Hydro physics model contains very high-resolution descriptions of terrestrial hydrologic process representations such as land-atmosphere exchanges of energy and moisture, snowpack evolution, infiltration, terrain routing, channel routing, basic reservoir representation and hydrologic data assimilation. Complementing the core physics components of WRF-Hydro are an ecosystem of pre- and post-processing tools that facilitate the preparation of terrain and meteorological input data, an open-source hydrologic model evaluation toolset (Rwrfhydro), hydrologic data assimilation capabilities with DART and advanced model visualization capabilities. The National Center for Atmospheric Research (NCAR), through collaborative support from the National Science Foundation and other funding partners, provides community support for the entire WRF-Hydro system through a variety of mechanisms. This presentation summarizes the enhanced user support capabilities that are being developed for the community WRF-Hydro modeling system. These products and services include a new website, open-source code repositories, documentation and user guides, test cases, online training materials, live, hands-on training sessions, an email list serve, and individual user support via email through a new help desk ticketing system. The WRF-Hydro modeling system and supporting tools which now include re-gridding scripts and model calibration have recently been updated to Version 4 and are merging toward capabilities of the National Water Model.

  9. Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease [version 1; referees: 3 approved

    Directory of Open Access Journals (Sweden)

    Alana M. Horowitz

    2017-08-01

    Full Text Available Neurodegenerative diseases are a devastating group of conditions that cause progressive loss of neuronal integrity, affecting cognitive and motor functioning in an ever-increasing number of older individuals. Attempts to slow neurodegenerative disease advancement have met with little success in the clinic; however, a new therapeutic approach may stem from classic interventions, such as caloric restriction, exercise, and parabiosis. For decades, researchers have reported that these systemic-level manipulations can promote major functional changes that extend organismal lifespan and healthspan. Only recently, however, have the functional effects of these interventions on the brain begun to be appreciated at a molecular and cellular level. The potential to counteract the effects of aging in the brain, in effect rejuvenating the aged brain, could offer broad therapeutic potential to combat dementia-related neurodegenerative disease in the elderly. In particular, results from heterochronic parabiosis and young plasma administration studies indicate that pro-aging and rejuvenating factors exist in the circulation that can independently promote or reverse age-related phenotypes. The recent demonstration that human umbilical cord blood similarly functions to rejuvenate the aged brain further advances this work to clinical translation. In this review, we focus on these blood-based rejuvenation strategies and their capacity to delay age-related molecular and functional decline in the aging brain. We discuss new findings that extend the beneficial effects of young blood to neurodegenerative disease models. Lastly, we explore the translational potential of blood-based interventions, highlighting current clinical trials aimed at addressing therapeutic applications for the treatment of dementia-related neurodegenerative disease in humans.

  10. Immunomodulating properties of Trino IB immunobooster

    African Journals Online (AJOL)

    STORAGESEVER

    2008-07-18

    Jul 18, 2008 ... irrespective of antigenic specificity, to augment immune response of other antigen or stimulate component of ... the non specific components of the immune system such as the macrophage/neutrophil innate ... Animal House, College of Medicine, University of Ibadan. The rats were allowed to acclimatize for ...

  11. Learning Negotiation Policies Using IB3 and Bayesian Networks

    Science.gov (United States)

    Nalepa, Gislaine M.; Ávila, Bráulio C.; Enembreck, Fabrício; Scalabrin, Edson E.

    This paper presents an intelligent offer policy in a negotiation environment, in which each agent involved learns the preferences of its opponent in order to improve its own performance. Each agent must also be able to detect drifts in the opponent's preferences so as to quickly adjust itself to their new offer policy. For this purpose, two simple learning techniques were first evaluated: (i) based on instances (IB3) and (ii) based on Bayesian Networks. Additionally, as its known that in theory group learning produces better results than individual/single learning, the efficiency of IB3 and Bayesian classifier groups were also analyzed. Finally, each decision model was evaluated in moments of concept drift, being the drift gradual, moderate or abrupt. Results showed that both groups of classifiers were able to effectively detect drifts in the opponent's preferences.

  12. Patient educational media preferences for information about irritable bowel syndrome (IBS).

    Science.gov (United States)

    Halpert, Albena; Dalton, Christine B; Palsson, Olafur; Morris, Carolyn; Hu, Yuming; Bangdiwala, Shrikant; Hankins, Jane; Norton, Nancy; Drossman, Douglas A

    2008-12-01

    To identify the educational media preferences of patients with irritable bowel syndrome (IBS). The IBS-Patient Education Questionnaire (PEQ) was administered to a national sample of IBS patients. Frequencies of item endorsements were compared and meaningful clinical differences were used to identify differences among subgroups. 1,242 patients completed the survey, mean age 39.3 years, 85% female, IBS duration 6.9 years, 79% had seen an MD for IBS within 6 months, and 92.6% used the web for medical information. The most desired source of education was "my doctor" (68%), followed by Internet (62%) and brochure (45%). Notably, patients favored an increase in use of media in the future (past vs. future): doctor (43 vs. 68%); Internet (36 vs. 62%); and brochures (26 vs. 45%). IBS patients expect more education than they have received. Understanding IBS patients' learning preferences can be highly valuable in the development or implementation of educational interventions.

  13. The role of stress in IBS symptom severity

    Directory of Open Access Journals (Sweden)

    Sanda Pletikosic

    2016-04-01

    Full Text Available Irritable bowel syndrome is regarded as a biopsychosocial disorder, the result of a complex combination of predisposing, precipitating and perpetuating factors. Personality traits, affective status and stress are some of the relevant factors contributing to lower quality of life and symptom exacerbation in IBS patients. In order to examine the role of stress in IBS symptom exacerbation, the aims of this study were to explore the relationship of daily stressful events and symptom severity in a prospective manner and to explore the roles of neuroticism, anxiety, depression and stress in the vicious circle of symptom perpetuation. A total of 49 patients with IBS reported their symptom severity and daily stressful events intensity each day for 14 consecutive days. They also completed the Big five personality inventory, the Beck Depression Inventory and the State-trait anxiety inventory. Cross-correlation analyses were performed on the time series data for daily stress and symptom severity for each participant separately. Four different patterns of relationships were found in different subgroups of participants: positive cross-correlations of symptom severity and stress intensity on the same day; higher symptom severity on days following stressful days; lower symptom severity on days following stressful days; and lower stress intensity on days following severe symptoms. Using average scores for daily stress and symptom severity, as well as scores for neuroticism, anxiety and depression, we performed a path analysis to test a model of symptom exacerbation. It showed that, on the group level, average stress intensity predicts average symptom severity. Neuroticism and anxiety were not significant predictors of symptom severity, while depression showed a marginally significant relationship with symptom severity, mediated by stress intensity. In conclusion, depression and daily stress seem to be important contributors to the vicious circle of IBS symptom

  14. INTEGRAL FIELD SPECTROSCOPY OF SUPERNOVA EXPLOSION SITES: CONSTRAINING THE MASS AND METALLICITY OF THE PROGENITORS. I. TYPE Ib AND Ic SUPERNOVAE

    Energy Technology Data Exchange (ETDEWEB)

    Kuncarayakti, Hanindyo; Maeda, Keiichi [Kavli Institute for the Physics and Mathematics of the Universe (WPI), Todai Institutes for Advanced Study, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8583 (Japan); Doi, Mamoru; Morokuma, Tomoki; Hashiba, Yasuhito [Institute of Astronomy, Graduate School of Science, The University of Tokyo, 2-21-1 Osawa, Mitaka, Tokyo 181-0015 (Japan); Aldering, Greg [Physics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Arimoto, Nobuo [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-0015 (Japan); Pereira, Rui [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, 4 Rue Enrico Fermi, F-69622 Villeurbanne Cedex (France); Usuda, Tomonori, E-mail: hanindyo.kuncarayakti@ipmu.jp [Subaru Telescope, National Astronomical Observatory of Japan, 650 North A' ohoku Place, Hilo, HI 96720 (United States)

    2013-08-01

    Integral field spectroscopy of 11 Type Ib/Ic supernova (SN Ib/Ic) explosion sites in nearby galaxies has been obtained using UH88/SNIFS and Gemini-N/GMOS. The use of integral field spectroscopy enables us to obtain both spatial and spectral information about the explosion site, enabling the identification of the parent stellar population of the SN progenitor star. The spectrum of the parent population provides metallicity determination via strong-line method and age estimation obtained via comparison with simple stellar population models. We adopt this information as the metallicity and age of the SN progenitor, under the assumption that it was coeval with the parent stellar population. The age of the star corresponds to its lifetime, which in turn gives the estimate of its initial mass. With this method we were able to determine both the metallicity and initial (zero-age main sequence) mass of the progenitor stars of SNe Ib and Ic. We found that on average SN Ic explosion sites are more metal-rich and younger than SN Ib sites. The initial mass of the progenitors derived from parent stellar population age suggests that SN Ic has more massive progenitors than SN Ib. In addition, we also found indication that some of our SN progenitors are less massive than {approx}25 M{sub Sun }, indicating that they may have been stars in a close binary system that have lost their outer envelope via binary interactions to produce SNe Ib/Ic, instead of single Wolf-Rayet stars. These findings support the current suggestions that both binary and single progenitor channels are in effect in producing SNe Ib/Ic. This work also demonstrates the power of integral field spectroscopy in investigating SN environments and active star-forming regions.

  15. Federal Emergency Management Information Systems (FEMIS), System Administration Guide FEMIS: Phase 1, Version 1.1u

    Energy Technology Data Exchange (ETDEWEB)

    Cerna, P.A.; Conner, W.M.; Curtis, L.M. [and others

    1995-06-01

    The Federal Emergency Management Information System (FEMIS) is an emergency management planning and analysis tool that is being developed under the direction of the U.S. Army Chemical Biological Defense Command. The FEMIS System Administration Guide defines FEMIS hardware and software requirements and gives instructions for installing the FEMIS software package.

  16. Wien Automatic System Planning (WASP) Package. A computer code for power generating system expansion planning. Version WASP-III Plus. User's manual. Volume 1: Chapters 1-11

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    As a continuation of its effort to provide comprehensive and impartial guidance to Member States facing the need for introducing nuclear power, the IAEA has completed a new version of the Wien Automatic System Planning (WASP) Package for carrying out power generation expansion planning studies. WASP was originally developed in 1972 in the USA to meet the IAEA's needs to analyze the economic competitiveness of nuclear power in comparison to other generation expansion alternatives for supplying the future electricity requirements of a country or region. The model was first used by the IAEA to conduct global studies (Market Survey for Nuclear Power Plants in Developing Countries, 1972-1973) and to carry out Nuclear Power Planning Studies for several Member States. The WASP system developed into a very comprehensive planning tool for electric power system expansion analysis. Following these developments, the so-called WASP-Ill version was produced in 1979. This version introduced important improvements to the system, namely in the treatment of hydroelectric power plants. The WASP-III version has been continually updated and maintained in order to incorporate needed enhancements. In 1981, the Model for Analysis of Energy Demand (MAED) was developed in order to allow the determination of electricity demand, consistent with the overall requirements for final energy, and thus, to provide a more adequate forecast of electricity needs to be considered in the WASP study. MAED and WASP have been used by the Agency for the conduct of Energy and Nuclear Power Planning Studies for interested Member States. More recently, the VALORAGUA model was completed in 1992 as a means for helping in the preparation of the hydro plant characteristics to be input in the WASP study and to verify that the WASP overall optimized expansion plan takes also into account an optimization of the use of water for electricity generation. The combined application of VALORAGUA and WASP permits the

  17. Wien Automatic System Planning (WASP) Package. A computer code for power generating system expansion planning. Version WASP-III Plus. User's manual. Volume 1: Chapters 1-11

    International Nuclear Information System (INIS)

    1995-01-01

    As a continuation of its effort to provide comprehensive and impartial guidance to Member States facing the need for introducing nuclear power, the IAEA has completed a new version of the Wien Automatic System Planning (WASP) Package for carrying out power generation expansion planning studies. WASP was originally developed in 1972 in the USA to meet the IAEA's needs to analyze the economic competitiveness of nuclear power in comparison to other generation expansion alternatives for supplying the future electricity requirements of a country or region. The model was first used by the IAEA to conduct global studies (Market Survey for Nuclear Power Plants in Developing Countries, 1972-1973) and to carry out Nuclear Power Planning Studies for several Member States. The WASP system developed into a very comprehensive planning tool for electric power system expansion analysis. Following these developments, the so-called WASP-Ill version was produced in 1979. This version introduced important improvements to the system, namely in the treatment of hydroelectric power plants. The WASP-III version has been continually updated and maintained in order to incorporate needed enhancements. In 1981, the Model for Analysis of Energy Demand (MAED) was developed in order to allow the determination of electricity demand, consistent with the overall requirements for final energy, and thus, to provide a more adequate forecast of electricity needs to be considered in the WASP study. MAED and WASP have been used by the Agency for the conduct of Energy and Nuclear Power Planning Studies for interested Member States. More recently, the VALORAGUA model was completed in 1992 as a means for helping in the preparation of the hydro plant characteristics to be input in the WASP study and to verify that the WASP overall optimized expansion plan takes also into account an optimization of the use of water for electricity generation. The combined application of VALORAGUA and WASP permits the

  18. The Digital Shoreline Analysis System (DSAS) Version 4.0 - An ArcGIS extension for calculating shoreline change

    Science.gov (United States)

    Thieler, E. Robert; Himmelstoss, Emily A.; Zichichi, Jessica L.; Ergul, Ayhan

    2009-01-01

    The Digital Shoreline Analysis System (DSAS) version 4.0 is a software extension to ESRI ArcGIS v.9.2 and above that enables a user to calculate shoreline rate-of-change statistics from multiple historic shoreline positions. A user-friendly interface of simple buttons and menus guides the user through the major steps of shoreline change analysis. Components of the extension and user guide include (1) instruction on the proper way to define a reference baseline for measurements, (2) automated and manual generation of measurement transects and metadata based on user-specified parameters, and (3) output of calculated rates of shoreline change and other statistical information. DSAS computes shoreline rates of change using four different methods: (1) endpoint rate, (2) simple linear regression, (3) weighted linear regression, and (4) least median of squares. The standard error, correlation coefficient, and confidence interval are also computed for the simple and weighted linear-regression methods. The results of all rate calculations are output to a table that can be linked to the transect file by a common attribute field. DSAS is intended to facilitate the shoreline change-calculation process and to provide rate-of-change information and the statistical data necessary to establish the reliability of the calculated results. The software is also suitable for any generic application that calculates positional change over time, such as assessing rates of change of glacier limits in sequential aerial photos, river edge boundaries, land-cover changes, and so on.

  19. Hypersensitivity reactions to anticancer agents: Data mining of the public version of the FDA adverse event reporting system, AERS

    Directory of Open Access Journals (Sweden)

    Sakaeda Toshiyuki

    2011-10-01

    Full Text Available Abstract Background Previously, adverse event reports (AERs submitted to the US Food and Drug Administration (FDA database were reviewed to confirm platinum agent-associated hypersensitivity reactions. The present study was performed to confirm whether the database could suggest the hypersensitivity reactions caused by anticancer agents, paclitaxel, docetaxel, procarbazine, asparaginase, teniposide, and etoposide. Methods After a revision of arbitrary drug names and the deletion of duplicated submissions, AERs involving candidate agents were analyzed. The National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 was applied to evaluate the susceptibility to hypersensitivity reactions, and standardized official pharmacovigilance tools were used for quantitative detection of signals, i.e., drug-associated adverse events, including the proportional reporting ratio, the reporting odds ratio, the information component given by a Bayesian confidence propagation neural network, and the empirical Bayes geometric mean. Results Based on 1,644,220 AERs from 2004 to 2009, the signals were detected for paclitaxel-associated mild, severe, and lethal hypersensitivity reactions, and docetaxel-associated lethal reactions. However, the total number of adverse events occurring with procarbazine, asparaginase, teniposide, or etoposide was not large enough to detect signals. Conclusions The FDA's adverse event reporting system, AERS, and the data mining methods used herein are useful for confirming drug-associated adverse events, but the number of co-occurrences is an important factor in signal detection.

  20. Seasonal prediction and predictability of Eurasian spring snow water equivalent in NCEP Climate Forecast System version 2 reforecasts

    Science.gov (United States)

    He, Qiong; Zuo, Zhiyan; Zhang, Renhe; Zhang, Ruonan

    2018-01-01

    The spring snow water equivalent (SWE) over Eurasia plays an important role in East Asian and Indian monsoon rainfall. This study evaluates the seasonal prediction capability of NCEP Climate Forecast System version 2 (CFSv2) retrospective forecasts (1983-2010) for the Eurasian spring SWE. The results demonstrate that CFSv2 is able to represent the climatological distribution of the observed Eurasian spring SWE with a lead time of 1-3 months, with the maximum SWE occurring over western Siberia and Northeastern Europe. For a longer lead time, the SWE is exaggerated in CFSv2 because the start of snow ablation in CFSv2 lags behind that of the observation, and the simulated snowmelt rate is less than that in the observation. Generally, CFSv2 can simulate the interannual variations of the Eurasian spring SWE 1-5 months ahead of time but with an exaggerated magnitude. Additionally, the downtrend in CFSv2 is also overestimated. Because the initial conditions (ICs) are related to the corresponding simulation results significantly, the robust interannual variability and the downtrend in the ICs are most likely the causes for these biases. Moreover, CFSv2 exhibits a high potential predictability for the Eurasian spring SWE, especially the spring SWE over Siberia, with a lead time of 1-5 months. For forecasts with lead times longer than 5 months, the model predictability gradually decreases mainly due to the rapid decrease in the model signal.

  1. iB1350 no.1. A generation III.7 reactor after the Fukushima Daiichi accident

    International Nuclear Information System (INIS)

    Sato, Takashi; Matsumoto, Keiji; Hosomi, Kenji; Kojima, Yoshihiro; Taguchi, Keisuke

    2017-01-01

    iB1350 stands for an innovative, intelligent and inexpensive BWR 1350. It is the first generation III.7 reactor after the Fukushima Daiichi accident. It has incorporated lessons learned from the Fukushima Daiichi accident and WENRA safety objectives. It has innovative safety to cope with devastating natural disasters including a giant earthquake, a large tsunami and a monster hurricane. The iB1350 can survive passively such devastation and a very prolonged SBO without any support from the outside of a site up to 7 days even preventing core melt. It, however, is based on the well-established proven ABWR design. The NSSS is exactly the same as that of the current ABWR. As for safety design, it has a double cylinder RCCV (Mark W containment) and in-depth hybrid safety systems (IDHS). The Mark W containment has double FP confinement barriers and the in-containment filtered venting system (IFVS) that enable passively no emergency evacuation outside the immediate vicinity of the plant for a SA. It has a large volume to hold hydrogen, an innovative core catcher (iCC), a passive flooding system and an innovative passive containment cooling system (iPCCS) establishing passively practical elimination of containment failure even in a long term. The IDHS consists of 4 division active safety systems for a DBA, 2 division active safety systems for a SA and built-in passive safety systems (BiPSS) consisting of an isolation condenser (IC) and the iPCCS for a SA. While the conventional PCCS can never cool the S/P, the iPCCS can automatically cool the S/P directly even in a DBA LOCA. That makes it possible for the iB1350 to optimize the active safety systems for a DBA. Sato came up with several optimized configurations of the IDHS that are expected to achieve further cost reduction and enhance its reliability resulting from passive feature of the iPCCS. The IC/iPCCS pool has enough capacity for 7 day grace period. The IC/iPCCS heat exchangers, the core and the spent fuel pool are

  2. Versioning of printed products

    Science.gov (United States)

    Tuijn, Chris

    2005-01-01

    During the definition of a printed product in an MIS system, a lot of attention is paid to the production process. The MIS systems typically gather all process-related parameters at such a level of detail that they can determine what the exact cost will be to make a specific product. This information can then be used to make a quote for the customer. Considerably less attention is paid to the content of the products since this does not have an immediate impact on the production costs (assuming that the number of inks or plates is known in advance). The content management is typically carried out either by the prepress systems themselves or by dedicated workflow servers uniting all people that contribute to the manufacturing of a printed product. Special care must be taken when considering versioned products. With versioned products we here mean distinct products that have a number of pages or page layers in common. Typical examples are comic books that have to be printed in different languages. In this case, the color plates can be shared over the different versions and the black plate will be different. Other examples are nation-wide magazines or newspapers that have an area with regional pages or advertising leaflets in different languages or currencies. When considering versioned products, the content will become an important cost factor. First of all, the content management (and associated proofing and approval cycles) becomes much more complex and, therefore, the risk that mistakes will be made increases considerably. Secondly, the real production costs are very much content-dependent because the content will determine whether plates can be shared across different versions or not and how many press runs will be needed. In this paper, we will present a way to manage different versions of a printed product. First, we will introduce a data model for version management. Next, we will show how the content of the different versions can be supplied by the customer

  3. Quantification of the level descriptors for the standard EQ-5D three-level system and a five-level version according to two methods

    NARCIS (Netherlands)

    Janssen, M. F.; Birnie, E.; Bonsel, G. J.

    2008-01-01

    OBJECTIVES: Our aim was to compare the quantitative position of the level descriptors of the standard EQ-5D three-level system (3L) and a newly developed, experimental five-level version (5L) using a direct and a vignette-based indirect method. METHODS: Eighty-two respondents took part in the study.

  4. Quantification of the level descriptors for the standard EQ-5D three-level system and a five-level version according to two methods

    NARCIS (Netherlands)

    M.F. Janssen (Bas); E. Birnie (Erwin); G.J. Bonsel (Gouke)

    2008-01-01

    textabstractObjectives: Our aim was to compare the quantitative position of the level descriptors of the standard EQ-5D three-level system (3L) and a newly developed, experimental five-level version (5L) using a direct and a vignette-based indirect method. Methods: Eighty-two respondents took part

  5. Inter-rater reliability of a modified version of Delitto et al.’s classification-based system for low back pain : a pilot study

    NARCIS (Netherlands)

    Apeldoorn, Adri T.; van Helvoirt, Hans; Ostelo, Raymond W.; Meihuizen, Hanneke; Kamper, Steven J.; van Tulder, Maurits W.; de Vet, Henrica C W

    2016-01-01

    Study design:: Observational inter-rater reliability study. Objectives: To examine: (1) the inter-rater reliability of a modified version of Delitto et al.’s classification-based algorithm for patients with low back pain; (2) the influence of different levels of familiarity with the system; and (3)

  6. The Gut-Brain Axis and the Microbiome: Clues to Pathophysiology and Opportunities for Novel Management Strategies in Irritable Bowel Syndrome (IBS

    Directory of Open Access Journals (Sweden)

    Eamonn M.M. Quigley

    2018-01-01

    Full Text Available Irritable bowel syndrome (IBS is one of the most common of all medical disorders worldwide and, while for some it represents no more than a nuisance, for others it imposes significant negative impacts on daily life and activities. IBS is a heterogeneous disorder and may well have a number of causes which may lie anywhere from the external environment to the contents of the gut lumen and from the enteric neuromuscular apparatus and the gut immune system to the central nervous system. Consequently, the paradigm of the gut-brain axis, which includes the participation of these various factors, has proven a useful model to assist clinicians and patients alike in understanding the genesis of symptoms in IBS. Now, given the widespread interest in the gut microbiome in health and disease, in general, reports of disordered enteric bacterial communities in IBS, and experimental data to indicate that components of the gut microbiota can influence brain morphology and function, as well as behavior and cognition, this concept has been extended to encompass the microbiota-gut-brain axis. The implications of this novel concept to the assessment and management of IBS will be explored in this review.

  7. ASYS2: a new version of computer algebra package ASYS for analysis and simplification of polynomial systems

    International Nuclear Information System (INIS)

    Gerdt, V.P.; Khutornoj, N.V.

    1993-01-01

    In this paper a new version of a package ASYS for analysis of nonlinear algebraic equations based on the Groebner basis technique is described. In addition to the first version ASYS1 of the package, the current one has a number of new facilities which provide its higher efficiency. Some examples and results of comparison between ASYS2, ASYS1 and two other REDUCE packages GROEBNER and CALI included in REDUCE 3.5, are given. 16 refs., 4 tabs

  8. Microbiota, gastrointestinal infections, low-grade inflammation, and antibiotic therapy in irritable bowel syndrome (IBS: an evidence-based review

    Directory of Open Access Journals (Sweden)

    Max Schmulson

    2014-04-01

    Conclusions: Further studies are required to determine the nature of the gut microbiota in IBS and the differences in low-grade inflammation between PI-IBS and non PI-IBS. Rifaximin has shown itself to be an effective treatment for IBS, regardless of prior factors.

  9. Preliminary full size test of a simplified version of the CMS link alignment system at the ISR hall

    International Nuclear Information System (INIS)

    Arce, P.; Calvo, E.; Figueroa, C.F.; Garcia, N.; Matorras, F.; Rodrigo, T.; Vila, I.; Virto, A.L.; Fernandez, M.G.; Ferrando, A.; Josa, M.I.; Molinero, A.; Oller, J.C.

    1999-01-01

    A preliminary full size test of a simplified version containing some relevant elements of the CMS (compact muon solenoid) Link Alignment System has been installed in an experimental area of the ISR (interaction storage ring) tunnel at CERN. Previously a calibration bench was prepared with standard precise survey methods. The environmental conditions, temperature, atmospheric pressure and relative humidity in the hall were controlled revealing quite stable conditions all along the tests period. The stability measurements done under these conditions show that the light spot on sensors located at about 6 m from the light source are smaller than 5 μm, which satisfies the requirements. Induced changes in the environmental conditions have different effects. Air flows degrades significantly the spatial resolution (∼5μm) but the background due to the environmental light does not degrades the resolution in position reconstruction. A geodesic network defines a reference system common to all opto-mechanical components and can be used to do absolute measurements of the angle between the two light beams coming out from the splitter. The accuracy in the reconstruction of angles with the help of the geodesic network depends on the errors in the network definition. These errors propagate with a smaller or larger strength depending on the distances between the network points. In our tests, the accuracy in the angle reconstruction is 14 μrad when using 4 in and 5.9 m long arms and 17 μrad for 4 m and 2.9 m arms. We found a precision 4 μrad in the angular reconstruction. (authors)

  10. EASI graphics - Version II

    International Nuclear Information System (INIS)

    Allensworth, J.A.

    1984-04-01

    EASI (Estimate of Adversary Sequence Interruption) is an analytical technique for measuring the effectiveness of physical protection systems. EASI Graphics is a computer graphics extension of EASI which provides a capability for performing sensitivity and trade-off analyses of the parameters of a physical protection system. This document reports on the implementation of the Version II of EASI Graphics and illustrates its application with some examples. 5 references, 15 figures, 6 tables

  11. Airspace Systems Program: Next Generation Air Transportation System Concepts and Technology Development FY2010 Project Plan Version 3.0

    Science.gov (United States)

    Kopardekar, Parimal H.

    2010-01-01

    This document describes the FY2010 plan for the management and execution of the Next Generation Air Transportation System (NextGen) Concepts and Technology Development (CTD) Project. The document was developed in response to guidance from the Airspace Systems Program (ASP), as approved by the Associate Administrator of the Aeronautics Research Mission Directorate (ARMD), and from guidelines in the Airspace Systems Program Plan. Congress established the multi-agency Joint Planning and Development Office (JPDO) in 2003 to develop a vision for the 2025 Next Generation Air Transportation System (NextGen) and to define the research required to enable it. NASA is one of seven agency partners contributing to the effort. Accordingly, NASA's ARMD realigned the Airspace Systems Program in 2007 to "directly address the fundamental research needs of the Next Generation Air Transportation System...in partnership with the member agencies of the JPDO." The Program subsequently established two new projects to meet this objective: the NextGen-Airspace Project and the NextGen-Airportal Project. Together, the projects will also focus NASA s technical expertise and world-class facilities to address the question of where, when, how and the extent to which automation can be applied to moving aircraft safely and efficiently through the NAS and technologies that address optimal allocation of ground and air technologies necessary for NextGen. Additionally, the roles and responsibilities of humans and automation influence in the NAS will be addressed by both projects. Foundational concept and technology research and development begun under the NextGen-Airspace and NextGen-Airportal projects will continue. There will be no change in NASA Research Announcement (NRA) strategy, nor will there be any change to NASA interfaces with the JPDO, Federal Aviation Administration (FAA), Research Transition Teams (RTTs), or other stakeholders

  12. A guide for the laboratory information management system (LIMS) for light stable isotopes--Versions 7 and 8

    Science.gov (United States)

    Coplen, Tyler B.

    2000-01-01

    The reliability and accuracy of isotopic data can be improved by utilizing database software to (i) store information about samples, (ii) store the results of mass spectrometric isotope-ratio analyses of samples, (iii) calculate analytical results using standardized algorithms stored in a database, (iv) normalize stable isotopic data to international scales using isotopic reference materials, and (v) generate multi-sheet paper templates for convenient sample loading of automated mass-spectrometer sample preparation manifolds. Such a database program, the Laboratory Information Management System (LIMS) for Light Stable Isotopes, is presented herein. Major benefits of this system include (i) a dramatic improvement in quality assurance, (ii) an increase in laboratory efficiency, (iii) a reduction in workload due to the elimination or reduction of retyping of data by laboratory personnel, and (iv) a decrease in errors in data reported to sample submitters. Such a database provides a complete record of when and how often laboratory reference materials have been analyzed and provides a record of what correction factors have been used through time. It provides an audit trail for laboratories. LIMS for Light Stable Isotopes is available for both Microsoft Office 97 Professional and Microsoft Office 2000 Professional as versions 7 and 8, respectively. Both source code (mdb file) and precompiled executable files (mde) are available. Numerous improvements have been made for continuous flow isotopic analysis in this version (specifically 7.13 for Microsoft Access 97 and 8.13 for Microsoft Access 2000). It is much easier to import isotopic results from Finnigan ISODAT worksheets, even worksheets on which corrections for amount of sample (linearity corrections) have been added. The capability to determine blank corrections using isotope mass balance from analyses of elemental analyzer samples has been added. It is now possible to calculate and apply drift corrections to isotopic

  13. Version control with Git

    CERN Document Server

    Loeliger, Jon

    2012-01-01

    Get up to speed on Git for tracking, branching, merging, and managing code revisions. Through a series of step-by-step tutorials, this practical guide takes you quickly from Git fundamentals to advanced techniques, and provides friendly yet rigorous advice for navigating the many functions of this open source version control system. This thoroughly revised edition also includes tips for manipulating trees, extended coverage of the reflog and stash, and a complete introduction to the GitHub repository. Git lets you manage code development in a virtually endless variety of ways, once you understand how to harness the system's flexibility. This book shows you how. Learn how to use Git for several real-world development scenarios ; Gain insight into Git's common-use cases, initial tasks, and basic functions ; Use the system for both centralized and distributed version control ; Learn how to manage merges, conflicts, patches, and diffs ; Apply advanced techniques such as rebasing, hooks, and ways to handle submodu...

  14. Impact of different LEED versions for green building certification and energy efficiency rating system: A Multifamily Midrise case study

    International Nuclear Information System (INIS)

    Rastogi, Ankush; Choi, Jun-Ki; Hong, Taehoon; Lee, Minhyun

    2017-01-01

    Highlights: •Energy consumption change from applying different LEED versions were investigated. •Four analysis scenarios were compared using different versions of ASHRAE Standard. •A case study of a mid-rise multi-family building was conducted using energy simulation. •Residential buildings could benefit from LEED v4 due to the low prerequisite. •Renovation buildings are highly incentivized regardless of LEED version used. -- Abstract: Various versions of the Leadership in Energy and Environmental Design (LEED ® ) have been introduced with the addition of more stringent sustainability parameters and credit scoring schemes over the past decade. Such changes in LEED versions strongly affect the energy performance and LEED scores of the target building in the LEED certification process. Therefore, to validate and improve the current LEED version, it is crucial to investigate and compare the impact of different LEED versions on the building energy performance and scoring scheme. However, researches comparing the sustainability metrics for mid-rise multi-family buildings are rare. Therefore, this paper investigates the potential changes in the energy performance resulted from applying different LEED versions (i.e., LEED v3 and v4) for the Energy and Atmosphere (EA) category. Towards this end, a case study was carried out with energy modeling and simulation using TRACE 700 to compare the changes in the energy performance of four analysis scenarios applied to an existing mid-rise multi-family building located in Ohio. Results showed notable changes in LEED points when different versions of LEED using different ASHRAE Standards (i.e., ASHRAE Standards 90.1-2007 and 90.1-2010) are applied for the building energy analysis. In particular, mid-rise multi-family buildings could benefit from LEED v4 in terms of LEED credits as the prerequisite for the minimum energy performance improvement in EA category became significantly lenient compared to LEED v3. On the

  15. Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life.

    Science.gov (United States)

    Böhn, Lena; Störsrud, Stine; Törnblom, Hans; Bengtsson, Ulf; Simrén, Magnus

    2013-05-01

    Despite the fact that food and diet are central issues, that concern patients with irritable bowel syndrome (IBS), the current understanding about the association between the intake of certain foods/food groups and the gastrointestinal (GI) symptom pattern, psychological symptoms, and quality of life is poor. The aim of this study was to determine which food groups and specific food items IBS patients report causing GI symptoms, and to investigate the association with GI and psychological symptoms and quality of life. We included 197 IBS patients (mean age 35 (18-72) years; 142 female subjects) who completed a food questionnaire in which they specified symptoms from 56 different food items or food groups relevant to food intolerance/allergy. The patients also completed questionnaires to assess depression and general anxiety (Hospital Anxiety and Depression), GI-specific anxiety (Visceral Sensitivity Index), IBS symptoms (IBS-Severity Scoring System), somatic symptoms (Patient Health Questionnaire-15), and quality of life (Irritable Bowel Syndrome Quality of Life Questionnaire). In all, 84% of the studied population reported symptoms related to at least one of the food items surveyed. Symptoms related to intake of food items with incompletely absorbed carbohydrates were noted in 138 (70%) patients; the most common were dairy products (49%), beans/lentils (36%), apple (28%), flour (24%), and plum (23%). Of these, 58% experienced GI symptoms from foods rich in biogenic amines, such as wine/beer (31%), salami (22%), and cheese (20%). Histamine-releasing foods, such as milk (43%), wine/beer (31%), and pork (21%), were also considered causes of symptoms in IBS patients. GI symptoms were also frequently reported after intake of fried and fatty foods (52%). With increasing IBS symptom severity, patients reported more food items responsible for their GI symptoms (P=0.004), and this was also found in patients with more severe somatic symptoms (Psleep (r=-0.25; P=0

  16. DET/MPS - THE GSFC ENERGY BALANCE PROGRAM, DIRECT ENERGY TRANSFER/MULTIMISSION SPACECRAFT MODULAR POWER SYSTEM (UNIX VERSION)

    Science.gov (United States)

    Jagielski, J. M.

    1994-01-01

    The DET/MPS programs model and simulate the Direct Energy Transfer and Multimission Spacecraft Modular Power System in order to aid both in design and in analysis of orbital energy balance. Typically, the DET power system has the solar array directly to the spacecraft bus, and the central building block of MPS is the Standard Power Regulator Unit. DET/MPS allows a minute-by-minute simulation of the power system's performance as it responds to various orbital parameters, focusing its output on solar array output and battery characteristics. While this package is limited in terms of orbital mechanics, it is sufficient to calculate eclipse and solar array data for circular or non-circular orbits. DET/MPS can be adjusted to run one or sequential orbits up to about one week, simulated time. These programs have been used on a variety of Goddard Space Flight Center spacecraft projects. DET/MPS is written in FORTRAN 77 with some VAX-type extensions. Any FORTRAN 77 compiler that includes VAX extensions should be able to compile and run the program with little or no modifications. The compiler must at least support free-form (or tab-delineated) source format and 'do do-while end-do' control structures. DET/MPS is available for three platforms: GSC-13374, for DEC VAX series computers running VMS, is available in DEC VAX Backup format on a 9-track 1600 BPI tape (standard distribution) or TK50 tape cartridge; GSC-13443, for UNIX-based computers, is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format; and GSC-13444, for Macintosh computers running AU/X with either the NKR FORTRAN or AbSoft MacFORTRAN II compilers, is available on a 3.5 inch 800K Macintosh format diskette. Source code and test data are supplied. The UNIX version of DET requires 90K of main memory for execution. DET/MPS was developed in 1990. A/UX and Macintosh are registered trademarks of Apple Computer, Inc. VMS, DEC VAX and TK50 are trademarks of Digital Equipment Corporation. UNIX is a

  17. Development of the SyncTraX FX4 version real-time tumor tracking system for radiation therapy

    International Nuclear Information System (INIS)

    Ishiyama, Tomoharu; Torigoe, Yui; Nagae, Koudai; Kajiki, Shunsuke; Sano, Takayuki

    2017-01-01

    Based on the current SyncTraX that was developed jointly with Hokkaido University, we have developed the SyncTraX FX4 version, which features not only tumor tracking but also patient positioning. The SyncTraX FX4 version is configured with four fixed x-ray tubes an detectors and eliminated the rail that is used to move the x-ray tube and detector as in the current SyncTraX. This development simplifies limitations on facility construction. We also adopted a distortion free flat panel detector instead of a color I.I., and the additional patient positioning feature will enable the SyncTraX FX4 version to become more widely applied in clinical cases. (author)

  18. Classification of ulnar triangular fibrocartilage complex tears. A treatment algorithm for Palmer type IB tears.

    Science.gov (United States)

    Atzei, A; Luchetti, R; Garagnani, L

    2017-05-01

    The classical definition of 'Palmer Type IB' triangular fibrocartilage complex tear, includes a spectrum of clinical conditions. This review highlights the clinical and arthroscopic criteria that enable us to categorize five classes on a treatment-oriented classification system of triangular fibrocartilage complex peripheral tears. Class 1 lesions represent isolated tears of the distal triangular fibrocartilage complex without distal radio-ulnar joint instability and are amenable to arthroscopic suture. Class 2 tears include rupture of both the distal triangular fibrocartilage complex and proximal attachments of the triangular fibrocartilage complex to the fovea. Class 3 tears constitute isolated ruptures of the proximal attachment of the triangular fibrocartilage complex to the fovea; they are not visible at radio-carpal arthroscopy. Both Class 2 and Class 3 tears are diagnosed with a positive hook test and are typically associated with distal radio-ulnar joint instability. If required, treatment is through reattachment of the distal radio-ulnar ligament insertions to the fovea. Class 4 lesions are irreparable tears due to the size of the defect or to poor tissue quality and, if required, treatment is through distal radio-ulnar ligament reconstruction with tendon graft. Class 5 tears are associated with distal radio-ulnar joint arthritis and can only be treated with salvage procedures. This subdivision of type IB triangular fibrocartilage complex tear provides more insights in the pathomechanics and treatment strategies. II.

  19. The Perceived Efficacy and Goal Setting System (PEGS), part II: evaluation of test-retest reliability and differences between child and parental reports in the Swedish version.

    Science.gov (United States)

    Vroland-Nordstrand, Kristina; Krumlinde-Sundholm, Lena

    2012-11-01

    to evaluate the test-retest reliability of children's perceptions of their own competence in performing daily tasks and of their choice of goals for intervention using the Swedish version of the perceived efficacy and goal setting system (PEGS). A second aim was to evaluate agreement between children's and parents' perceptions of the child's competence and choices of intervention goals. Forty-four children with disabilities and their parents completed the Swedish version of the PEGS. Thirty-six of the children completed a retest session allocated into one of two groups: (A) for evaluation of perceived competence and (B) for evaluation of choice of goals. Cohen's kappa, weighted kappa and absolute agreement were calculated. Test-retest reliability for children's perceived competence showed good agreement for the dichotomized scale of competent/non-competent performance; however, using the four-point scale the agreement varied. The children's own goals were relatively stable over time; 78% had an absolute agreement ranging from 50% to 100%. There was poor agreement between the children's and their parents' ratings. Goals identified by the children differed from those identified by their parents, with 48% of the children having no goals identical to those chosen by their parents. These results indicate that the Swedish version of the PEGS produces reliable outcomes comparable to the original version.

  20. PVWatts Version 5 Manual

    Energy Technology Data Exchange (ETDEWEB)

    Dobos, A. P.

    2014-09-01

    The NREL PVWatts calculator is a web application developed by the National Renewable Energy Laboratory (NREL) that estimates the electricity production of a grid-connected photovoltaic system based on a few simple inputs. PVWatts combines a number of sub-models to predict overall system performance, and makes includes several built-in parameters that are hidden from the user. This technical reference describes the sub-models, documents assumptions and hidden parameters, and explains the sequence of calculations that yield the final system performance estimate. This reference is applicable to the significantly revised version of PVWatts released by NREL in 2014.

  1. Unedited Version

    Indian Academy of Sciences (India)

    58

    Identification of RNA-specific adenosine deaminase 1 (ADAR1) gene results in ... youth male patient with a deleterious substitution of Leu1052Pro of ADAR1 ... reaction system contained 14.75 µl double-distilled water, 2.5 µl 10X buffer, 2 µl.

  2. version 10

    African Journals Online (AJOL)

    lviljoen

    In South Africa, 70% of the country's population is dependent on the public health care sector ... (231.23% more than the actual budget allocation) is needed for the optimal functioning .... on average 98% or R214.8-billion of their adjusted bud- ... achieve better control and estimation of projected ... stratified sampling system.

  3. A unique set of SH3-SH3 interactions controls IB1 homodimerization

    DEFF Research Database (Denmark)

    Kristensen, Ole; Guenat, Sylvie; Dar, Imran

    2006-01-01

    Islet-brain 1 (IB1 or JIP-1) is a scaffold protein that interacts with components of the c-Jun N-terminal kinase (JNK) signal-transduction pathway. IB1 is expressed at high levels in neurons and in pancreatic beta-cells, where it controls expression of several insulin-secretory components...... reduces IB1-dependent basal JNK activity in 293T cells. Impaired dimerization also results in a reduction in glucose transporter type 2 expression and in glucose-dependent insulin secretion in pancreatic beta-cells. Taken together, these results indicate that IB1 homodimerization through its SH3 domain...

  4. Influence of microstructure on laser damage threshold of IBS coatings

    International Nuclear Information System (INIS)

    Stolz, C.J.; Genin, F.Y.; Kozlowski, M.R.; Long, D.; Lalazari, R.; Wu, Z.L.; Kuo, P.K.

    1996-01-01

    Ion-beam sputtering (IBS) coatings were developed for the laser gyro industry to meet significantly different requirements than those of fusion lasers. Laser gyro mirrors are small ( 26 J/cm 2 at 1,064 nm with 3-ns pulses). As part of the National Ignition Facility (NIF) coating development effort, IBS coatings are being studied to explore the possible benefits of this technology to NIF optics. As an initial step to achieving the NIF size and damage threshold requirements, the coating process is being scaled to uniformly coat a 20 x 40 cm 2 area with reduced spectral, reflected wavefront, and laser damage threshold requirements. Here, multilayer coatings deposited by ion-beam sputtering with amorphous layers were found to have lower damage thresholds at 1,064 nm than similar coatings with crystalline layers. Interestingly, at higher fluences the damage was less severe for the amorphous coatings. The magnitude of the difference in damage thresholds between the two different microstructures was strongly influenced by the size of the tested area. To better understand the microstructure effects, single layers of HfO 2 with different microstructures were studied using transmission electron microscopy, ellipsometry, and a photothermal deflection technique. Since the laser damage initiated at defects, the influence of thermal diffusivity on thermal gradients in nodular defects is also presented

  5. [Abdominal spasms, meteorism, diarrhea: fructose intolerance, lactose intolerance or IBS?].

    Science.gov (United States)

    Litschauer-Poursadrollah, Margaritha; El-Sayad, Sabine; Wantke, Felix; Fellinger, Christina; Jarisch, Reinhart

    2012-12-01

    Meteorism, abdominal spasms, diarrhea, casually obstipation, flatulence and nausea are symptoms of fructose malabsorption (FIT) and/or lactose intolerance (LIT), but are also symptoms of irritable bowel syndrome (IBS). Therefore these diseases should be considered primarily in patients with digestive complaints. For diagnosis an H(2)-breath test is used.In 1,935 patients (526 m, 1,409 f) a fructose intolerance test and in 1,739 patients (518 m,1,221 f) a lactose intolerance test was done.FIT is found more frequently than LIT (57 versus 52 % in adults (p intolerance (HIT). Headache (ca. 10 %), fatigue (ca. 5 %) and dizziness (ca. 3 %) may occur after the test, irrespective whether the test was positive or negative.In more than 2/3 of patients a diet reduced in fructose or lactose may lead to improvement or remission of these metabolic disorders. IBS, which is often correlated with FIT (183/221 patients = 83 %), can be improved by relevant but also not relevant diets indicating that irritable bowel disease seems to be caused primarily by psychological disorders.

  6. Systems analysis programs for Hands-on integrated reliability evaluations (SAPHIRE) Version 5.0: Verification and validation (V ampersand V) manual. Volume 9

    International Nuclear Information System (INIS)

    Jones, J.L.; Calley, M.B.; Capps, E.L.; Zeigler, S.L.; Galyean, W.J.; Novack, S.D.; Smith, C.L.; Wolfram, L.M.

    1995-03-01

    A verification and validation (V ampersand V) process has been performed for the System Analysis Programs for Hands-on Integrated Reliability Evaluation (SAPHIRE) Version 5.0. SAPHIRE is a set of four computer programs that NRC developed for performing probabilistic risk assessments. They allow an analyst to perform many of the functions necessary to create, quantify, and evaluate the risk associated with a facility or process being analyzed. The programs are Integrated Reliability and Risk Analysis System (IRRAS) System Analysis and Risk Assessment (SARA), Models And Results Database (MAR-D), and Fault tree, Event tree, and Piping and instrumentation diagram (FEP) graphical editor. Intent of this program is to perform a V ampersand V of successive versions of SAPHIRE. Previous efforts have been the V ampersand V of SAPHIRE Version 4.0. The SAPHIRE 5.0 V ampersand V plan is based on the SAPHIRE 4.0 V ampersand V plan with revisions to incorporate lessons learned from the previous effort. Also, the SAPHIRE 5.0 vital and nonvital test procedures are based on the test procedures from SAPHIRE 4.0 with revisions to include the new SAPHIRE 5.0 features as well as to incorporate lessons learned from the previous effort. Most results from the testing were acceptable; however, some discrepancies between expected code operation and actual code operation were identified. Modifications made to SAPHIRE are identified

  7. Carcinoma of the uterine cervix stage IB and early stage II. Prognostic value of the histological tumor regression after initial brachytherapy

    International Nuclear Information System (INIS)

    Calais, G.; Le Floch, O.; Chauvet, B.; Reynaud-Bougnoux, A.; Bougnoux, P.

    1989-01-01

    In our center limited centro pelvic invasive carcinomas of the uterine cervix (less than 4 cm) are treated with brachytherapy and surgery. With these therapeutic modalities no residual carcinoma was observed for 80% of the patients. The purpose of this study was to evaluate our results with this treatment, and to evaluate the prognostic value of the pathological status of the cervix. From 1976 to 1987 we have treated 115 patients with these modalities. Staging system used was the FIGO classification modified for Stage II (divided in early Stage II and late Stage II). Patients were Stage IB (70 cases) and early Stage II (45 cases); 60 Gy were delivered with utero vaginal brachytherapy before any treatment. Six weeks later a radical hysterectomy with pelvic lymphadenectomy was performed. Twenty-one patients with positive nodes received a pelvic radiotherapy (45 to 55 Gy). Local control rate was 97% (100% for Stage IB and 93% for early Stage II). Uncorrected 10-year actuarial survival rate was 96% for Stage IB and 80% for early Stage II patients. No treatment failure was observed for Stage IB patients. Ninety-two patients (80%) had no residual carcinoma in the cervix (group 1) and 23 patients (20%) had a residual tumor (group 2). The sterilization rate of the cervix was 87% for Stage IB tumors versus 69% for early Stage II, and was 82% for N- patients versus 68% for N+ patients. Ten year actuarial survival rate was 92% for group 1 and 78% for group 2 (p = 0, 1). Grade 3 complications rate was 6%. We conclude that brachytherapy + surgery is a safe treatment for limited centro pelvic carcinomas of the uterine cervix (especially Stage IB) and that pathological status of the cervix after brachytherapy is not a prognostic factor

  8. Provision of a draft version for standard classification structure for information of radiation technologies through analyzing their information and derivation of its applicable requirements to the information system

    International Nuclear Information System (INIS)

    Jang, Sol Ah; Kim, Joo Yeon; Yoo, Ji Yup; Shin, Woo Ho; Park, Tai Jin; Song, Myung Jae

    2015-01-01

    Radiation technology is the one for developing new products or processes by applying radiation or for creating new functions in industry, research and medical fields, and its application is increasing consistently. For securing an advanced technology competitiveness, it is required to create a new added value by information consumer through providing an efficient system for supporting information, which is the infrastructure for research and development, contributed to its collection, analysis and use with a rapidity and structure in addition to some direct research and development. Provision of the management structure for information resources is especially crucial for efficient operating the system for supporting information in radiation technology, and then a standard classification structure of information must be first developed as the system for supporting information will be constructed. The standard classification structure has been analyzed by reviewing the definition of information resources in radiation technology, and those classification structures in similar systems operated by institute in radiation and other scientific fields. And, a draft version of the standard classification structure has been then provided as 7 large, 25 medium and 71 small classifications, respectively. The standard classification structure in radiation technology will be developed in 2015 through reviewing this draft version and experts' opinion. Finally, developed classification structure will be applied to the system for supporting information by considering the plan for constructing this system and database, and requirements for designing the system. Furthermore, this structure will be designed in the system for searching information by working to the individual need of information consumers

  9. Provision of a draft version for standard classification structure for information of radiation technologies through analyzing their information and derivation of its applicable requirements to the information system

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Sol Ah; Kim, Joo Yeon; Yoo, Ji Yup; Shin, Woo Ho; Park, Tai Jin; Song, Myung Jae [Korean Association for Radiation Application, Seoul (Korea, Republic of)

    2015-02-15

    Radiation technology is the one for developing new products or processes by applying radiation or for creating new functions in industry, research and medical fields, and its application is increasing consistently. For securing an advanced technology competitiveness, it is required to create a new added value by information consumer through providing an efficient system for supporting information, which is the infrastructure for research and development, contributed to its collection, analysis and use with a rapidity and structure in addition to some direct research and development. Provision of the management structure for information resources is especially crucial for efficient operating the system for supporting information in radiation technology, and then a standard classification structure of information must be first developed as the system for supporting information will be constructed. The standard classification structure has been analyzed by reviewing the definition of information resources in radiation technology, and those classification structures in similar systems operated by institute in radiation and other scientific fields. And, a draft version of the standard classification structure has been then provided as 7 large, 25 medium and 71 small classifications, respectively. The standard classification structure in radiation technology will be developed in 2015 through reviewing this draft version and experts' opinion. Finally, developed classification structure will be applied to the system for supporting information by considering the plan for constructing this system and database, and requirements for designing the system. Furthermore, this structure will be designed in the system for searching information by working to the individual need of information consumers.

  10. A new fun and robust version of an fMRI localizer for the frontotemporal language system.

    Science.gov (United States)

    Scott, Terri L; Gallée, Jeanne; Fedorenko, Evelina

    2017-07-01

    A set of brain regions in the frontal, temporal, and parietal lobes supports high-level linguistic processing. These regions can be reliably identified in individual subjects using fMRI, by contrasting neural responses to meaningful and structured language stimuli vs. stimuli matched for low-level properties but lacking meaning and/or structure. We here present a novel version of a language 'localizer,' which should be suitable for diverse populations including children and/or clinical populations who may have difficulty with reading or cognitively demanding tasks. In particular, we contrast responses to auditorily presented excerpts from engaging interviews or stories, and acoustically degraded versions of these materials. This language localizer is appealing because it uses (a) naturalistic and engaging linguistic materials, (b) auditory presentation, (c) a passive listening task, and can be easily adapted to new stimulus materials enabling comparisons of language activation in children and speakers of diverse languages.

  11. SACRD: a data base for fast reactor safety computer codes, contents and glossary of Version 1 of the system

    International Nuclear Information System (INIS)

    Greene, N.M.; Forsberg, V.M.; Raiford, G.B.; Arwood, J.W.; Flanagan, G.F.

    1979-01-01

    SACRD is a data base of material properties and other handbook data needed in computer codes used for fast reactor safety studies. This document lists the contents of Version 1 and also serves as a glossary of terminology used in the data base. Data are available in the thermodynamics, heat transfer, fluid mechanics, structural mechanics, aerosol transport, meteorology, neutronics and dosimetry areas. Tabular, graphical and parameterized data are provided in many cases

  12. A constructive version of AIP revisited

    NARCIS (Netherlands)

    Barros, A.; Hou, T.

    2008-01-01

    In this paper, we review a constructive version of the Approximation Induction Principle. This version states that bisimilarity of regular processes can be decided by observing only a part of their behaviour. We use this constructive version to formulate a complete inference system for the Algebra

  13. Wien Automatic System Package (WASP). A computer code for power generating system expansion planning. Version WASP-III Plus. User's manual. Volume 2: Appendices

    International Nuclear Information System (INIS)

    1995-01-01

    With several Member States, the IAEA has completed a new version of the WASP program, which has been called WASP-Ill Plus since it follows quite closely the methodology of the WASP-Ill model. The major enhancements in WASP-Ill Plus with respect to the WASP-Ill version are: increase in the number of thermal fuel types (from 5 to 10); verification of which configurations generated by CONGEN have already been simulated in previous iterations with MERSIM; direct calculation of combined Loading Order of FIXSYS and VARSYS plants; simulation of system operation includes consideration of physical constraints imposed on some fuel types (i.e., fuel availability for electricity generation); extended output of the resimulation of the optimal solution; generation of a file that can be used for graphical representation of the results of the resimulation of the optimal solution and cash flows of the investment costs; calculation of cash flows allows to include the capital costs of plants firmly committed or in construction (FIXSYS plants); user control of the distribution of capital cost expenditures during the construction period (if required to be different from the general 'S' curve distribution used as default). This second volume of the document to support use of the WASP-Ill Plus computer code consists of 5 appendices giving some additional information about the WASP-Ill Plus program. Appendix A is mainly addressed to the WASP-Ill Plus system analyst and supplies some information which could help in the implementation of the program on the user computer facilities. This appendix also includes some aspects about WASP-Ill Plus that could not be treated in detail in Chapters 1 to 11. Appendix B identifies all error and warning messages that may appear in the WASP printouts and advises the user how to overcome the problem. Appendix C presents the flow charts of the programs along with a brief description of the objectives and structure of each module. Appendix D describes the

  14. More negative self-esteem and inferior coping strategies among patients diagnosed with IBS compared with patients without IBS - a case-control study in primary care

    OpenAIRE

    Grodzinsky, Ewa; Walter, Susanna; Viktorsson, Lisa; Carlsson, Ann-Kristin; Jones, Michael P.; Olsen Faresjö, Ashild

    2015-01-01

    Background Irritable Bowel Syndrome (IBS) is a chronic, relapsing gastrointestinal disorder,that affects approximately 10% of the general population and the majority are diagnosed  in primary care. IBS has been reported to be associated with altered psychological and cognitive functioning such as mood disturbances, somatization, catastrophizing or altered visceral interoception by negative emotions and stress. The aim was to  investigate the psychosocial constructs of self-esteem and sense of...

  15. Exclusion of the GNAS locus in PHP-Ib patients with broad GNAS methylation changes: evidence for an autosomal recessive form of PHP-Ib?

    Science.gov (United States)

    Fernández-Rebollo, Eduardo; Pérez de Nanclares, Guiomar; Lecumberri, Beatriz; Turan, Serap; Anda, Emma; Pérez-Nanclares, Gustavo; Feig, Denice; Nik-Zainal, Serena; Bastepe, Murat; Jüppner, Harald

    2011-08-01

    Most patients with autosomal dominant pseudohypoparathyroidism type Ib (AD-PHP-Ib) carry maternally inherited microdeletions upstream of GNAS that are associated with loss of methylation restricted to GNAS exon A/B. Only few AD-PHP-Ib patients carry microdeletions within GNAS that are associated with loss of all maternal methylation imprints. These epigenetic changes are often indistinguishable from those observed in patients affected by an apparently sporadic PHP-Ib form that has not yet been defined genetically. We have now investigated six female patients affected by PHP-Ib (four unrelated and two sisters) with complete or almost complete loss of GNAS methylation, whose healthy children (11 in total) showed no epigenetic changes at this locus. Analysis of several microsatellite markers throughout the 20q13 region made it unlikely that PHP-Ib is caused in these patients by large deletions involving GNAS or by paternal uniparental isodisomy or heterodisomy of chromosome 20 (patUPD20). Microsatellite and single-nucleotide variation (SNV) data revealed that the two affected sisters share their maternally inherited GNAS alleles with unaffected relatives that lack evidence for abnormal GNAS methylation, thus excluding linkage to this locus. Consistent with these findings, healthy children of two unrelated sporadic PHP-Ib patients had inherited different maternal GNAS alleles, also arguing against linkage to this locus. Based on our data, it appears plausible that some forms of PHP-Ib are caused by homozygous or compound heterozygous mutation(s) in an unknown gene involved in establishing or maintaining GNAS methylation. Copyright © 2011 American Society for Bone and Mineral Research.

  16. Fragmentation of the CRISPR-Cas Type I-B signature protein Cas8b.

    Science.gov (United States)

    Richter, Hagen; Rompf, Judith; Wiegel, Julia; Rau, Kristina; Randau, Lennart

    2017-11-01

    CRISPR arrays are transcribed into long precursor RNA species, which are further processed into mature CRISPR RNAs (crRNAs). Cas proteins utilize these crRNAs, which contain spacer sequences that can be derived from mobile genetic elements, to mediate immunity during a reoccurring virus infection. Type I CRISPR-Cas systems are defined by the presence of different Cascade interference complexes containing large and small subunits that play major roles during target DNA selection. Here, we produce the protein and crRNA components of the Type I-B CRISPR-Cas complex of Clostridium thermocellum and Methanococcus maripaludis. The C. thermocellum Cascade complexes were reconstituted and analyzed via size-exclusion chromatography. Activity of the heterologous M. maripaludis CRISPR-Cas system was followed using phage lambda plaques assays. The reconstituted Type-I-B Cascade complex contains Cas7, Cas5, Cas6b and the large subunit Cas8b. Cas6b can be omitted from the reconstitution protocol. The large subunit Cas8b was found to be represented by two tightly associated protein fragments and a small C-terminal Cas8b segment was identified in recombinant complexes and C. thermocellum cell lysate. Production of Cas8b generates a small C-terminal fragment, which is suggested to fulfill the role of the missing small subunit. A heterologous, synthetic M. maripaludis Type I-B system is active in E. coli against phage lambda, highlighting a potential for genome editing using endogenous Type-I-B CRISPR-Cas machineries. This article is part of a Special Issue entitled "Biochemistry of Synthetic Biology - Recent Developments" Guest Editor: Dr. Ilka Heinemann and Dr. Patrick O'Donoghue. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. La Inscripción Ibérica en escritura jonia, Serreta IX.

    OpenAIRE

    Silgo Gauche, Luís

    1997-01-01

    S’estudía una nova inscripció sobre làmina de plom, localitzada casualment en l’àrea del poblat ibèric de la Serreta (Alcoi, Cocentaina, Penàguila), en l’escriptura del qual es van emprar caracters greco-ibèrics.

  18. Politics and Pedagogy: Discursive Constructions in the IB "Theory of Knowledge--Guide"

    Science.gov (United States)

    Smith, Nigel V.; Morgan, Mandy

    2010-01-01

    The International Baccalaureate (IB) curriculum is increasingly popular in both national and international secondary education settings. The "Theory of knowledge" (TOK) course is cast as the prime example of the international globalised values the IB Diploma represents. This article argues that such a positioning is contested within the TOK…

  19. Land Boundary Conditions for the Goddard Earth Observing System Model Version 5 (GEOS-5) Climate Modeling System: Recent Updates and Data File Descriptions

    Science.gov (United States)

    Mahanama, Sarith P.; Koster, Randal D.; Walker, Gregory K.; Takacs, Lawrence L.; Reichle, Rolf H.; De Lannoy, Gabrielle; Liu, Qing; Zhao, Bin; Suarez, Max J.

    2015-01-01

    The Earths land surface boundary conditions in the Goddard Earth Observing System version 5 (GEOS-5) modeling system were updated using recent high spatial and temporal resolution global data products. The updates include: (i) construction of a global 10-arcsec land-ocean lakes-ice mask; (ii) incorporation of a 10-arcsec Globcover 2009 land cover dataset; (iii) implementation of Level 12 Pfafstetter hydrologic catchments; (iv) use of hybridized SRTM global topography data; (v) construction of the HWSDv1.21-STATSGO2 merged global 30 arc second soil mineral and carbon data in conjunction with a highly-refined soil classification system; (vi) production of diffuse visible and near-infrared 8-day MODIS albedo climatologies at 30-arcsec from the period 2001-2011; and (vii) production of the GEOLAND2 and MODIS merged 8-day LAI climatology at 30-arcsec for GEOS-5. The global data sets were preprocessed and used to construct global raster data files for the software (mkCatchParam) that computes parameters on catchment-tiles for various atmospheric grids. The updates also include a few bug fixes in mkCatchParam, as well as changes (improvements in algorithms, etc.) to mkCatchParam that allow it to produce tile-space parameters efficiently for high resolution AGCM grids. The update process also includes the construction of data files describing the vegetation type fractions, soil background albedo, nitrogen deposition and mean annual 2m air temperature to be used with the future Catchment CN model and the global stream channel network to be used with the future global runoff routing model. This report provides detailed descriptions of the data production process and data file format of each updated data set.

  20. Aportaciones coloniales a las creencias funerarias ibéricas

    Directory of Open Access Journals (Sweden)

    Joaquín García Raya

    1999-01-01

    Full Text Available La «mediterraneidad» de la península ibérica ha producido una serie de contactos con otros pueblos de esta cuenca, atraídos por su riqueza minera o como recurso a la colmatación de sus territorios de origen, lo cual produjo una traslación de ritos funerarios, cuya lectura arqueológica ha significado interpretaciones erróneas básicas.The "Mediterranean style» of the Iberian Península has given way to a series of contacts wth otherpeoples fron this valley, attracted by its mining richness and as an option tgo the overcrowding of their native territories. This brought about the implantation of funeral ceremonies, who archaelogical reading has meant false interpretations.

  1. Revision, uptake and coding issues related to the open access Orchard Sports Injury Classification System (OSICS versions 8, 9 and 10.1

    Directory of Open Access Journals (Sweden)

    John Orchard

    2010-10-01

    Full Text Available John Orchard1, Katherine Rae1, John Brooks2, Martin Hägglund3, Lluis Til4, David Wales5, Tim Wood61Sports Medicine at Sydney University, Sydney NSW Australia; 2Rugby Football Union, Twickenham, England, UK; 3Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; 4FC Barcelona, Barcelona, Catalonia, Spain; 5Arsenal FC, Highbury, England, UK; 6Tennis Australia, Melbourne, Vic, AustraliaAbstract: The Orchard Sports Injury Classification System (OSICS is one of the world’s most commonly used systems for coding injury diagnoses in sports injury surveillance systems. Its major strengths are that it has wide usage, has codes specific to sports medicine and that it is free to use. Literature searches and stakeholder consultations were made to assess the uptake of OSICS and to develop new versions. OSICS was commonly used in the sports of football (soccer, Australian football, rugby union, cricket and tennis. It is referenced in international papers in three sports and used in four commercially available computerised injury management systems. Suggested injury categories for the major sports are presented. New versions OSICS 9 (three digit codes and OSICS 10.1 (four digit codes are presented. OSICS is a potentially helpful component of a comprehensive sports injury surveillance system, but many other components are required. Choices made in developing these components should ideally be agreed upon by groups of researchers in consensus statements.Keywords: sports injury classification, epidemiology, surveillance, coding

  2. Revision, uptake and coding issues related to the open access Orchard Sports Injury Classification System (OSICS) versions 8, 9 and 10.1

    Science.gov (United States)

    Orchard, John; Rae, Katherine; Brooks, John; Hägglund, Martin; Til, Lluis; Wales, David; Wood, Tim

    2010-01-01

    The Orchard Sports Injury Classification System (OSICS) is one of the world’s most commonly used systems for coding injury diagnoses in sports injury surveillance systems. Its major strengths are that it has wide usage, has codes specific to sports medicine and that it is free to use. Literature searches and stakeholder consultations were made to assess the uptake of OSICS and to develop new versions. OSICS was commonly used in the sports of football (soccer), Australian football, rugby union, cricket and tennis. It is referenced in international papers in three sports and used in four commercially available computerised injury management systems. Suggested injury categories for the major sports are presented. New versions OSICS 9 (three digit codes) and OSICS 10.1 (four digit codes) are presented. OSICS is a potentially helpful component of a comprehensive sports injury surveillance system, but many other components are required. Choices made in developing these components should ideally be agreed upon by groups of researchers in consensus statements. PMID:24198559

  3. Risk model in stage IB1-IIB cervical cancer with positive node after radical hysterectomy

    Directory of Open Access Journals (Sweden)

    Chen Z

    2016-05-01

    were defined using these variables. Five-year DFS rates for the low-, intermediate-, and high-risk groups were 73.7%, 60.0%, and 25.0%, respectively (P<0.001, and 5-year OS rates were 81.9%, 42.8%, and 25.0%, respectively (P<0.001. The risk model derived in this study provides a novel means for assessing prognosis of patients with node-positive stage IB1-IIB cervical cancer. Future study will focus on external validation of the model and refinement of the risk scoring systems by adding new biologic markers.Keywords: cervical cancer, risk model, lymph node metastasis, disease-free survival, overall survival

  4. The implementation of the CDC version of RELAP5/MOD1/019 on an IBM compatible computer system (AMDAHL 470/V8)

    International Nuclear Information System (INIS)

    Kolar, W.; Brewka, W.

    1984-01-01

    RELAP5/MOD1 is an advanced one-dimensional best estimate system code, which is used for safety analysis studies of nuclear pressurized water reactor systems and related integral and separate effect test facilities. The program predicts the system response for large break, small break LOCA and special transients. To a large extent RELAP5/MOD1 is written in Fortran, only a small part of the program is coded in CDC assembler. RELAP5/MOD1 was developed on the CDC CYBER 176 at INEL*. The code development team made use of CDC system programs like the CDC UPDATE facility and incorporated in the program special purpose software packages. The report describes the problems which have been encountered when implementing the CDC version of RELAP5/MOD1 on an IBM compatible computer systems (AMDAHL 470/V8)

  5. Detergent-Resistant Membrane Microdomains Facilitate Ib Oligomer Formation and Biological Activity of Clostridium perfringens Iota-Toxin

    National Research Council Canada - National Science Library

    Hale, Martha

    2004-01-01

    ...) were extracted with cold Triton X-100. Western blotting revealed that Ib oligomers localized in DRMs extracted from Vero, but not MRC-5, cells while monomeric Ib was detected in the detergent-soluble fractions of both cell types...

  6. New, Improved Version of the mCOP-PCR Screening System for Detection of Spinal Muscular Atrophy Gene (SMN1) Deletion.

    Science.gov (United States)

    Shinohara, Masakazu; Ar Rochmah, Mawaddah; Nakanishi, Kenta; Harahap, Nur Imma Fatimah; Niba, Emma Tabe Eko; Saito, Toshio; Saito, Kayoko; Takeuchi, Atsuko; Bouike, Yoshihiro; Nishio, Hisahide

    2017-09-07

    Spinal muscular atrophy (SMA) is a frequent autosomal recessive disorder, characterized by lower motor neuron loss in the spinal cord. More than 95% of SMA patients show homozygous survival motor neuron 1 (SMN1) deletion. We previously developed a screening system for SMN1 deletion based on a modified competitive oligonucleotide priming-PCR (mCOP-PCR) technique. However, non-specific amplification products were observed with mCOP-PCR, which might lead to erroneous interpretation of the screening results. To establish an improved version of the mCOP-PCR screening system without non-specific amplification. DNA samples were assayed using a new version of the mCOP-PCR screening system. DNA samples had already been genotyped by PCR-restriction fragment length polymorphism (PCR-RFLP), showing the presence or absence of SMN1 exon 7. The new mCOP-PCR method contained a targeted pre-amplification step of the region, including an SMN1-specific nucleotide, prior to the mCOP-PCR step. mCOP-PCR products were electrophoresed on agarose gels. No non-specific amplification products were detected in electrophoresis gels with the new mCOP-PCR screening system. An additional targeted pre-amplification step eliminated non-specific amplification from mCOP-PCR screening.

  7. Translation, Cross-Cultural Adaptation, and Validation of the Malay Version of the System Usability Scale Questionnaire for the Assessment of Mobile Apps.

    Science.gov (United States)

    Mohamad Marzuki, Muhamad Fadhil; Yaacob, Nor Azwany; Yaacob, Najib Majdi

    2018-05-14

    A mobile app is a programmed system designed to be used by a target user on a mobile device. The usability of such a system refers not only to the extent to which product can be used to achieve the task that it was designed for, but also its effectiveness and efficiency, as well as user satisfaction. The System Usability Scale is one of the most commonly used questionnaires used to assess the usability of a system. The original 10-item version of System Usability Scale was developed in English and thus needs to be adapted into local languages to assess the usability of a mobile apps developed in other languages. The aim of this study is to translate and validate (with cross-cultural adaptation) the English System Usability Scale questionnaire into Malay, the main language spoken in Malaysia. The development of a translated version will allow the usability of mobile apps to be assessed in Malay. Forward and backward translation of the questionnaire was conducted by groups of Malay native speakers who spoke English as their second language. The final version was obtained after reconciliation and cross-cultural adaptation. The content of the Malay System Usability Scale questionnaire for mobile apps was validated by 10 experts in mobile app development. The efficacy of the questionnaire was further probed by testing the face validity on 10 mobile phone users, followed by reliability testing involving 54 mobile phone users. The content validity index was determined to be 0.91, indicating good relevancy of the 10 items used to assess the usability of a mobile app. Calculation of the face validity index resulted in a value of 0.94, therefore indicating that the questionnaire was easily understood by the users. Reliability testing showed a Cronbach alpha value of .85 (95% CI 0.79-0.91) indicating that the translated System Usability Scale questionnaire is a reliable tool for the assessment of usability of a mobile app. The Malay System Usability Scale questionnaire is a

  8. Convergence of Health Level Seven Version 2 Messages to Semantic Web Technologies for Software-Intensive Systems in Telemedicine Trauma Care.

    Science.gov (United States)

    Menezes, Pedro Monteiro; Cook, Timothy Wayne; Cavalini, Luciana Tricai

    2016-01-01

    To present the technical background and the development of a procedure that enriches the semantics of Health Level Seven version 2 (HL7v2) messages for software-intensive systems in telemedicine trauma care. This study followed a multilevel model-driven approach for the development of semantically interoperable health information systems. The Pre-Hospital Trauma Life Support (PHTLS) ABCDE protocol was adopted as the use case. A prototype application embedded the semantics into an HL7v2 message as an eXtensible Markup Language (XML) file, which was validated against an XML schema that defines constraints on a common reference model. This message was exchanged with a second prototype application, developed on the Mirth middleware, which was also used to parse and validate both the original and the hybrid messages. Both versions of the data instance (one pure XML, one embedded in the HL7v2 message) were equally validated and the RDF-based semantics recovered by the receiving side of the prototype from the shared XML schema. This study demonstrated the semantic enrichment of HL7v2 messages for intensive-software telemedicine systems for trauma care, by validating components of extracts generated in various computing environments. The adoption of the method proposed in this study ensures the compliance of the HL7v2 standard in Semantic Web technologies.

  9. A modified fetal heart rate tracing interpretation system for prediction of cesarean section

    Science.gov (United States)

    Schnettler, William T.; Rogers, Jennifer; Barber, Rachel E.; Hacker, Michele R.

    2013-01-01

    Objective To investigate whether a modified version of the 2008 National Institute of Child Health and Human Development (NICHD) interpretation system upon admission decreases cesarean delivery risk. Methods This retrospective cohort study ascribed a modified category to the first 30 min of fetal heart rate (FHR) tracings in labor. Category I was divided into two subsets (Ia and Ib) by the presence of accelerations. Category II was divided into four subsets (IIa–IId) based on baseline FHR, variability, response to stimulation and decelerations. Log-binomial regression was used to calculate risk ratios (RR) and 95% confidence intervals (CI). Results A category was ascribed to 910 women. Most FHR tracings were Category Ia (65.8%), Ib (7.7%), IIb (11.8%) and IId (14.0%). Category Ib tracings (fewer than two accelerations) were 2.26 (95% CI: 1.13–4.52) times more likely to result in cesarean delivery for abnormal FHR tracing than Category Ia tracings. A similar increase in risk was seen when comparing Category IIb and Category IId with Category Ia. Conclusion Application of a modified version of the 2008 NICHD FHR interpretation system to the initial 30 min of labor can identify women at increased risk of cesarean delivery for abnormal FHR tracing. PMID:21942513

  10. The INTERPRET Decision-Support System version 3.0 for evaluation of Magnetic Resonance Spectroscopy data from human brain tumours and other abnormal brain masses

    Directory of Open Access Journals (Sweden)

    Mercadal Guillem

    2010-11-01

    Full Text Available Abstract Background Proton Magnetic Resonance (MR Spectroscopy (MRS is a widely available technique for those clinical centres equipped with MR scanners. Unlike the rest of MR-based techniques, MRS yields not images but spectra of metabolites in the tissues. In pathological situations, the MRS profile changes and this has been particularly described for brain tumours. However, radiologists are frequently not familiar to the interpretation of MRS data and for this reason, the usefulness of decision-support systems (DSS in MRS data analysis has been explored. Results This work presents the INTERPRET DSS version 3.0, analysing the improvements made from its first release in 2002. Version 3.0 is aimed to be a program that 1st, can be easily used with any new case from any MR scanner manufacturer and 2nd, improves the initial analysis capabilities of the first version. The main improvements are an embedded database, user accounts, more diagnostic discrimination capabilities and the possibility to analyse data acquired under additional data acquisition conditions. Other improvements include a customisable graphical user interface (GUI. Most diagnostic problems included have been addressed through a pattern-recognition based approach, in which classifiers based on linear discriminant analysis (LDA were trained and tested. Conclusions The INTERPRET DSS 3.0 allows radiologists, medical physicists, biochemists or, generally speaking, any person with a minimum knowledge of what an MR spectrum is, to enter their own SV raw data, acquired at 1.5 T, and to analyse them. The system is expected to help in the categorisation of MR Spectra from abnormal brain masses.

  11. Nonsense mutation in the glycoprotein Ibα coding sequence associated with Bernard-Soulier syndrome

    International Nuclear Information System (INIS)

    Ware, J.; Russell, S.R.; Vicente, V.; Scharf, R.E.; Tomer, A.; McMillian, R.; Ruggeri, Z.M.

    1990-01-01

    Three distinct gene products, the α and β chains of glycoprotein (GP) Ib and GP IX, constitute the platelet membrane GP Ib-IX complex, a receptor for von Willebrand factor and thrombin involved in platelet adhesion and aggregation. Defective function of the GP Ib-IX complex is the hallmark of a rare congenital bleeding disorder of still undefined pathogenesis, the Bernard-Soulier syndrome. The authors have analyzed the molecular basis of the disease in one patient in whom immunoblotting of solubilized platelets demonstrated absence of normal GP Ibα but presence of a smaller immunoreactive species. The truncated polypeptide was also present, along with normal protein, in platelets from the patient's mother and two of his four children. Genetic characterization identified a nucleotide transition changing the Trp-343 codon (TGG) to a nonsense codon (TGA). Such a mutation explains the origin of the smaller GP Ibα, which by lacking half of the sequence on the carboxyl-terminal side, including the transmembrane domain, cannot be properly inserted in the platelet membrane. Both normal and mutant codons were found in the patient, suggesting that he is a compound heterozygote with a still unidentified defect in the other GP Ibα allele. Nonsense mutation and truncated GP Ibα polypeptide were found to cosegregate in four individuals through three generations and were associated with either Bernard-Soulier syndrome or carrier state phenotype. The molecular abnormality demonstrated in this family provides evidence that defective synthesis of GP Ibα alters the membrane expression of the GP Ib-IX complex and may be responsible for Bernard-Soulier syndrome

  12. Pseudohypoparathyroidism type Ib associated with novel duplications in the GNAS locus.

    Directory of Open Access Journals (Sweden)

    Gustavo Perez-Nanclares

    Full Text Available Pseudohypoparathyroidism type 1b (PHP-Ib is characterized by renal resistance to PTH (and, sometimes, a mild resistance to TSH and absence of any features of Albright's hereditary osteodystrophy. Patients with PHP-Ib suffer of defects in the methylation pattern of the complex GNAS locus. PHP-Ib can be either sporadic or inherited in an autosomal dominant pattern. Whereas familial PHP-Ib is well characterized at the molecular level, the genetic cause of sporadic PHP-Ib cases remains elusive, although some molecular mechanisms have been associated with this subtype.The aim of the study was to investigate the molecular and imprinting defects in the GNAS locus in two unrelated patients with PHP-Ib.We have analyzed the GNAS locus by direct sequencing, Methylation-Specific Multiplex Ligation-dependent Probe Amplification, microsatellites, Quantitative Multiplex PCR of Short Fluorescent fragments and array-Comparative Genomic Hybridization studies in order to characterize two unrelated families with clinical features of PHP-Ib.We identified two duplications in the GNAS region in two patients with PHP-Ib: one of them, comprising ∼ 320 kb, occurred 'de novo' in the patient, whereas the other one, of ∼ 179 kb in length, was inherited from the maternal allele. In both cases, no other known genetic cause was observed.In this article, we describe the to-our-knowledge biggest duplications reported so far in the GNAS region. Both are associated to PHP-Ib, one of them occurring 'de novo' and the other one being maternally inherited.

  13. Migraine, fibromyalgia, and depression among people with IBS: a prevalence study

    Directory of Open Access Journals (Sweden)

    Cabral Howard J

    2006-09-01

    Full Text Available Abstract Background Case descriptions suggest IBS patients are more likely to have other disorders, including migraine, fibromyalgia, and depression. We sought to examine the prevalence of these conditions in cohorts of people with and without IBS. Methods The source of data was a large U.S. health plan from January 1, 1996 though June 30, 2002. We identified all people with a medical claim associated with an ICD-9 code for IBS. A non-IBS cohort was a random sample of people with an ICD-9 code for routine medical care. In the cohorts, we identified all claims for migraine, depression, and fibromyalgia. We estimated the prevalence odds ratios (PORs of each of the three conditions using the Mantel-Haenszel method. We conducted quantitative sensitivity analyses to quantify the impact of residual confounding and in differential outcome identification. Results We identified 97,593 people in the IBS cohort, and a random sample of 27,402 people to compose the non-IBS comparison cohort. With adjustment, there was a 60% higher odds in the IBS cohort of having any one of the three disorders relative to the comparison cohort (POR 1.6, 95% CI 1.5 – 1.7. There was a 40% higher odds of depression in the IBS cohort (POR 1.4, 95% CI 1.3 – 1.4. The PORs for fibromyalgia and migraine were similar (POR for fibromyalgia 1.8, 95% CI 1.7 – 1.9; POR for migraine 1.6, 95% CI 1.4 – 1.7. Differential prevalence of an unmeasured confounder, or imperfect sensitivity or specificity of outcome detection would have impacted the observed results. Conclusion People in the IBS cohort had a 40% to 80% higher prevalence odds of migraine, fibromyalgia, and depression.

  14. Improving the stability of alpha-conotoxin AuIB through N-to-C cyclization

    DEFF Research Database (Denmark)

    Armishaw, Christopher J; Jensen, Anders A; Balle, Lena D

    2011-01-01

    Modification of alpha-conotoxin frameworks through cyclization via an oligopeptide linker has previously been shown as an effective strategy for improving in vivo stability. We have extended this strategy by investigating cyclic analogs of alpha-conotoxin AuIB, a selective alpha3beta4 nicotinic a......-AuIB. As such, the cAuIB-2 globular isomer could constitute a useful probe for studying the role of the alpha3beta4 nicotinic acetylcholine receptor in a range of in vivo experimental paradigms....

  15. GENII Version 2 Users’ Guide

    Energy Technology Data Exchange (ETDEWEB)

    Napier, Bruce A.

    2004-03-08

    The GENII Version 2 computer code was developed for the Environmental Protection Agency (EPA) at Pacific Northwest National Laboratory (PNNL) to incorporate the internal dosimetry models recommended by the International Commission on Radiological Protection (ICRP) and the radiological risk estimating procedures of Federal Guidance Report 13 into updated versions of existing environmental pathway analysis models. The resulting environmental dosimetry computer codes are compiled in the GENII Environmental Dosimetry System. The GENII system was developed to provide a state-of-the-art, technically peer-reviewed, documented set of programs for calculating radiation dose and risk from radionuclides released to the environment. The codes were designed with the flexibility to accommodate input parameters for a wide variety of generic sites. Operation of a new version of the codes, GENII Version 2, is described in this report. Two versions of the GENII Version 2 code system are available, a full-featured version and a version specifically designed for demonstrating compliance with the dose limits specified in 40 CFR 61.93(a), the National Emission Standards for Hazardous Air Pollutants (NESHAPS) for radionuclides. The only differences lie in the limitation of the capabilities of the user to change specific parameters in the NESHAPS version. This report describes the data entry, accomplished via interactive, menu-driven user interfaces. Default exposure and consumption parameters are provided for both the average (population) and maximum individual; however, these may be modified by the user. Source term information may be entered as radionuclide release quantities for transport scenarios, or as basic radionuclide concentrations in environmental media (air, water, soil). For input of basic or derived concentrations, decay of parent radionuclides and ingrowth of radioactive decay products prior to the start of the exposure scenario may be considered. A single code run can

  16. Binary phase diagrams based on elements VIIIA and IB periods of the D.I. Mendeleev’s table and features of crystallographic parameters

    Science.gov (United States)

    Potekaev, A. I.; Klopotov, A. A.; Porobova, S. A.; Klopotov, V. D.; Markova, T. N.; Imanaliev, M. I.

    2017-01-01

    The data obtained as a result of the analysis of crystallogeometric parameters and the structure of state diagrams of binary systems from elements VIIIA and IB periods of the D.I. Mendeleev’s table are presented. It is shown that the classification of the evolution of phase diagrams of binary systems by types, proposed by T.A. Lebedev, correlates with features of concentration dependences of the deviation of atomic volumes in solid solutions from Zen law.

  17. Airspace Systems Program: Next Generation Air Transportation System, NextGen Systems Analysis, Integration and Evaluation Project. Version 1.0; Project Plan

    Science.gov (United States)

    Quon, Leighton

    2010-01-01

    The key objectives of the NASA ASP are to: Improve mobility, capacity efficiency and access of the airspace system. Improve collaboration, predictability, and flexibility for the airspace users. Enable accurate modeling and simulation of air transportation systems. Accommodate operations of all classes of aircraft. Maintain system safety and environmental protection. In support of these program objectives, the major goal of the NextGen-SAIE Project is to enable the transition of key capacity and efficiency improvements to the NAS. Since many aspects of the NAS are unique to specific airport or airspace environments, demand on various parts of the NAS is not expected to increase equally as system demand grows. SAIE will provide systems level analysis of the NAS characteristics, constraints, and demands such that a suite of capacity-increasing concepts and technologies for system solutions are enabled and facilitated. The technical objectives in support of this goal are the following: Integration, evaluation, and transition of more mature concepts and technologies in an environment that faithfully emulates real-world complexities. Interoperability research and analysis of ASP technologies across ATM functions is performed to facilitate integration and take ASP concepts and technologies to higher Technology Readiness Level (TRL). Analyses are conducted on the program s concepts to identify the system benefits or impacts. System level analysis is conducted to increase understanding of the characteristics and constraints of airspace system and its domains.

  18. IB4(+) nociceptors mediate persistent muscle pain induced by GDNF.

    Science.gov (United States)

    Alvarez, Pedro; Chen, Xiaojie; Bogen, Oliver; Green, Paul G; Levine, Jon D

    2012-11-01

    Skeletal muscle is a well-known source of glial cell line-derived neurotrophic factor (GDNF), which can produce mechanical hyperalgesia. Since some neuromuscular diseases are associated with both increased release of GDNF and intense muscle pain, we explored the role of GDNF as an endogenous mediator in muscle pain. Intramuscularly injected GDNF induced a dose-dependent (0.1-10 ng/20 μl) persistent (up to 3 wk) mechanical hyperalgesia in the rat. Once hyperalgesia subsided, injection of prostaglandin E(2) at the site induced a prolonged mechanical hyperalgesia (>72 h) compared with naïve rats (vibration increased muscle GDNF levels at 24 h, a time point where rats also exhibited marked muscle hyperalgesia. Intrathecal antisense oligodeoxynucleotides to mRNA encoding GFRα1, the canonical binding receptor for GDNF, reversibly inhibited eccentric exercise- and mechanical vibration-induced muscle hyperalgesia. Finally, electrophysiological recordings from nociceptors innervating the gastrocnemius muscle in anesthetized rats, revealed significant increase in response to sustained mechanical stimulation after local GDNF injection. In conclusion, these data indicate that GDNF plays a role as an endogenous mediator in acute and induction of chronic muscle pain, an effect likely to be produced by GDNF action at GFRα1 receptors located in IB4(+) nociceptors.

  19. Users Guide for Fire Image Analysis System - Version 5.0: A Tool for Measuring Fire Behavior Characteristics

    Science.gov (United States)

    Carl W. Adkins

    1995-01-01

    The Fire Image Analysis System is a tool for quantifying flame geometry and relative position at selected points along a spreading line fire. At present, the system requires uniform terrain (constant slope). The system has been used in field and laboratory studies for determining flame length, depth, cross sectional area, and rate of spread.

  20. Phenotyping of subjects for large scale studies on patients with IBS

    NARCIS (Netherlands)

    Boeckxstaens, G. E.; Drug, V.; Dumitrascu, D.; Farmer, A. D.; Hammer, J.; Hausken, T.; Niesler, B.; Pohl, D.; Pojskic, L.; Polster, A.; Simren, M.; Goebel-Stengel, M.; van Oudenhove, L.; Vassallo, M.; Wensaas, K.-A.; Aziz, Q.; Houghton, L. A.

    2016-01-01

    Background Irritable bowel syndrome (IBS) is a complex condition with multiple factors contributing to its aetiology and pathophysiology. Aetiologically these include genetics, life-time events and environment, and physiologically, changes in motility, central processing, visceral sensitivity,

  1. Proteomics analysis of IBS-D with spleen and kidney yang deficiency

    Directory of Open Access Journals (Sweden)

    Yijie Li

    2017-01-01

    Conclusion: These data suggest that SKYD/IBS-D pathophysiology likely involves inflammation, cell growth, apoptosis, stress granule formation, immune activation, loss of epithelial cell integrity, and visceral hypersensitivity.

  2. EBAA: An efficient broadcast authentication scheme for ADS-B communication based on IBS-MR

    Directory of Open Access Journals (Sweden)

    Yang Haomiao

    2014-06-01

    Full Text Available Automatic dependent surveillance-broadcast (ADS-B systems can broadcast satellite-based aircraft position, identification, etc., periodically, and are now on track to replace radar to become the backbone of next-generation air traffic management (ATM systems. However, ADS-B systems suffer severe cyber-security problems due to the broadcast-type data link and the lack of designed-in security measures. Especially, since ADS-B messages are unauthenticated, it is easy to insert fake aircraft into a system via spoofing or insertion of false messages. Unfortunately, the authentication for ADS-B messages has not yet been well studied. In this paper, based on identity-based signature with message recovery (IBS-MR, an efficient broadcast authentication scheme for ADS-B messages is proposed. The security analysis demonstrates that the scheme can achieve authenticity and integrity of ADS-B broadcast messages, as well as adaptive evolution of broadcasters’ private keys. The performance evaluation shows that the scheme is computationally efficient for typical avionics devices with limited resources. Furthermore, the scheme achieves low communication overhead since broadcast messages can be recovered from signatures, and thus it is suitable for low-bandwidth ADS-B data link.

  3. Impacts of Interactive Stratospheric Chemistry on Antarctic and Southern Ocean Climate Change in the Goddard Earth Observing System Version 5 (GEOS-5)

    Science.gov (United States)

    Li, Feng; Vikhliaev, Yury V.; Newman, Paul A.; Pawson, Steven; Perlwitz, Judith; Waugh, Darryn W.; Douglass, Anne R.

    2016-01-01

    Stratospheric ozone depletion plays a major role in driving climate change in the Southern Hemisphere. To date, many climate models prescribe the stratospheric ozone layer's evolution using monthly and zonally averaged ozone fields. However, the prescribed ozone underestimates Antarctic ozone depletion and lacks zonal asymmetries. In this study we investigate the impact of using interactive stratospheric chemistry instead of prescribed ozone on climate change simulations of the Antarctic and Southern Ocean. Two sets of 1960-2010 ensemble transient simulations are conducted with the coupled ocean version of the Goddard Earth Observing System Model, version 5: one with interactive stratospheric chemistry and the other with prescribed ozone derived from the same interactive simulations. The model's climatology is evaluated using observations and reanalysis. Comparison of the 1979-2010 climate trends between these two simulations reveals that interactive chemistry has important effects on climate change not only in the Antarctic stratosphere, troposphere, and surface, but also in the Southern Ocean and Antarctic sea ice. Interactive chemistry causes stronger Antarctic lower stratosphere cooling and circumpolar westerly acceleration during November-December-January. It enhances stratosphere-troposphere coupling and leads to significantly larger tropospheric and surface westerly changes. The significantly stronger surface wind stress trends cause larger increases of the Southern Ocean Meridional Overturning Circulation, leading to year-round stronger ocean warming near the surface and enhanced Antarctic sea ice decrease.

  4. iPTF13bvn: The first evidence of a binary progenitor for a type Ib supernova

    Energy Technology Data Exchange (ETDEWEB)

    Bersten, Melina C.; Folatelli, Gastón; Nomoto, Ken' ichi; Quimby, Robert [Kavli Institute for the Physics and Mathematics of the Universe (WPI), The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8583 (Japan); Benvenuto, Omar G. [Facultad de Ciencias Astronómicas y Geofísicas, Universidad Nacional de La Plata, Paseo del Bosque S/N, B1900FWA La Plata (Argentina); Kuncarayakti, Hanindyo [Millennium Institute of Astrophysics, Casilla 36-D, Santiago (Chile); Srivastav, Shubham; Anupama, G. C.; Sahu, Devendra K., E-mail: melina.bersten@ipmu.jp [Indian Institute of Astrophysics, Koramangala, Bangalore 560034 (India)

    2014-10-01

    The recent detection in archival Hubble Space Telescope images of an object at the location of supernova (SN) iPTF13bvn may represent the first direct evidence of the progenitor of a Type Ib SN. The object's photometry was found to be compatible with a Wolf-Rayet pre-SN star mass of ≈11 M {sub ☉}. However, based on hydrodynamical models, we show that the progenitor had a pre-SN mass of ≈3.5 M {sub ☉} and that it could not be larger than ≈8 M {sub ☉}. We propose an interacting binary system as the SN progenitor and perform evolutionary calculations that are able to self-consistently explain the light curve shape, the absence of hydrogen, and the pre-SN photometry. We further discuss the range of allowed binary systems and predict that the remaining companion is a luminous O-type star of significantly lower flux in the optical than the pre-SN object. A future detection of such a star may be possible and would provide the first robust identification of a progenitor system for a Type Ib SN.

  5. H+ -pyrophosphatase IbVP1 promotes efficient iron use in sweet potato [Ipomoea batatas (L.) Lam.].

    Science.gov (United States)

    Fan, Weijuan; Wang, Hongxia; Wu, Yinliang; Yang, Nan; Yang, Jun; Zhang, Peng

    2017-06-01

    Iron (Fe) deficiency is one of the most common micronutrient deficiencies limiting crop production globally, especially in arid regions because of decreased availability of iron in alkaline soils. Sweet potato [Ipomoea batatas (L.) Lam.] grows well in arid regions and is tolerant to Fe deficiency. Here, we report that the transcription of type I H + -pyrophosphatase (H + -PPase) gene IbVP1 in sweet potato plants was strongly induced by Fe deficiency and auxin in hydroponics, improving Fe acquisition via increased rhizosphere acidification and auxin regulation. When overexpressed, transgenic plants show higher pyrophosphate hydrolysis and plasma membrane H + -ATPase activity compared with the wild type, leading to increased rhizosphere acidification. The IbVP1-overexpressing plants showed better growth, including enlarged root systems, under Fe-sufficient or Fe-deficient conditions. Increased ferric precipitation and ferric chelate reductase activity in the roots of transgenic lines indicate improved iron uptake, which is also confirmed by increased Fe content and up-regulation of Fe uptake genes, e.g. FRO2, IRT1 and FIT. Carbohydrate metabolism is significantly affected in the transgenic lines, showing increased sugar and starch content associated with the increased expression of AGPase and SUT1 genes and the decrease in β-amylase gene expression. Improved antioxidant capacities were also detected in the transgenic plants, which showed reduced H 2 O 2 accumulation associated with up-regulated ROS-scavenging activity. Therefore, H + -PPase plays a key role in the response to Fe deficiency by sweet potato and effectively improves the Fe acquisition by overexpressing IbVP1 in crops cultivated in micronutrient-deficient soils. © 2016 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  6. A Formal Approach to Exploiting Multi-Stage Attacks based on File-System Vulnerabilities of Web Applications (Extended Version)

    OpenAIRE

    De Meo, Federico; Viganò, Luca

    2017-01-01

    Web applications require access to the file-system for many different tasks. When analyzing the security of a web application, secu- rity analysts should thus consider the impact that file-system operations have on the security of the whole application. Moreover, the analysis should take into consideration how file-system vulnerabilities might in- teract with other vulnerabilities leading an attacker to breach into the web application. In this paper, we first propose a classification of file-...

  7. WSPEEDI (worldwide version of SPEEDI): A computer code system for the prediction of radiological impacts on Japanese due to a nuclear accident in foreign countries

    Energy Technology Data Exchange (ETDEWEB)

    Chino, Masamichi; Yamazawa, Hiromi; Nagai, Haruyasu; Moriuchi, Shigeru [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Ishikawa, Hirohiko

    1995-09-01

    A computer code system has been developed for near real-time dose assessment during radiological emergencies. The system WSPEEDI, the worldwide version of SPEEDI (System for Prediction of Environmental Emergency Dose Information) aims at predicting the radiological impact on Japanese due to a nuclear accident in foreign countries. WSPEEDI consists of a mass-consistent wind model WSYNOP for large-scale wind fields and a particle random walk model GEARN for atmospheric dispersion and dry and wet deposition of radioactivity. The models are integrated into a computer code system together with a system control software, worldwide geographic database, meteorological data processor and graphic software. The performance of the models has been evaluated using the Chernobyl case with reliable source terms, well-established meteorological data and a comprehensive monitoring database. Furthermore, the response of the system has been examined by near real-time simulations of the European Tracer Experiment (ETEX), carried out over about 2,000 km area in Europe. (author).

  8. WSPEEDI (worldwide version of SPEEDI): A computer code system for the prediction of radiological impacts on Japanese due to a nuclear accident in foreign countries

    International Nuclear Information System (INIS)

    Chino, Masamichi; Yamazawa, Hiromi; Nagai, Haruyasu; Moriuchi, Shigeru; Ishikawa, Hirohiko.

    1995-09-01

    A computer code system has been developed for near real-time dose assessment during radiological emergencies. The system WSPEEDI, the worldwide version of SPEEDI (System for Prediction of Environmental Emergency Dose Information) aims at predicting the radiological impact on Japanese due to a nuclear accident in foreign countries. WSPEEDI consists of a mass-consistent wind model WSYNOP for large-scale wind fields and a particle random walk model GEARN for atmospheric dispersion and dry and wet deposition of radioactivity. The models are integrated into a computer code system together with a system control software, worldwide geographic database, meteorological data processor and graphic software. The performance of the models has been evaluated using the Chernobyl case with reliable source terms, well-established meteorological data and a comprehensive monitoring database. Furthermore, the response of the system has been examined by near real-time simulations of the European Tracer Experiment (ETEX), carried out over about 2,000 km area in Europe. (author)

  9. The ties that bind: perceived social support, stress, and IBS in severely affected patients.

    Science.gov (United States)

    Lackner, J M; Brasel, A M; Quigley, B M; Keefer, L; Krasner, S S; Powell, C; Katz, L A; Sitrin, M D

    2010-08-01

    This study assessed the association between social support and the severity of irritable bowel syndrome (IBS) symptoms in a sample of severely affected IBS patients recruited to an NIH-funded clinical trial. In addition, we examined if the effects of social support on IBS pain are mediated through the effects on stress. Subjects were 105 Rome II diagnosed IBS patients (F = 85%) who completed seven questionnaires which were collected as part of a pretreatment baseline assessment. Partial correlations were conducted to clarify the relationships between social support and clinically relevant variables with baseline levels of psychopathology, holding constant number of comorbid medical diseases, age, gender, marital status, ethnicity, and education. Analyses indicated that social support was inversely related to IBS symptom severity. Social support was positively related with less severe pain. A similar pattern of data was found for perceived stress but not quality of life impairment. Regression analyses examined if the effects of social support on pain are mediated by stress. The effects of social support on bodily pain were mediated by stress such that the greater the social support the less stress and the less pain. This effect did not hold for symptom severity, quality of life, or psychological distress. This study links the perceived adequacy of social support to the global severity of symptoms of IBS and its cardinal symptom (pain). It also suggests that the mechanism by which social support alleviates pain is through a reduction in stress levels.

  10. The International Baccalaureate (IB programme: An international gateway to higher education and beyond

    Directory of Open Access Journals (Sweden)

    Susan E. Saxton

    2014-09-01

    Full Text Available The aim of this article is to present the International Baccalaureate (IB Programme and briefly outline its core components, followed by a review of what authoritative reports identify as skills for the future, esteemed by universities and the job market. There is a striking match between these skills and IB outcomes; thus, DP graduates perform well in higher education and add to the reputation of those institutions. After a review of the literature, the authors found the IB Diploma Programme has been studied in many countries by both consultants and educational agencies, and also by a wide array of universities themselves; however, there are fewer qualitative studies concerning the degree to which IB graduates display attitudes, values, and behaviours in line with the IB Learner Profile. This is why the authors stress the claims made are supported by examples of significant research, noting that there is a dearth of qualitative longitudinal studies to sufficiently substantiate the affective domain claims that currently rely more on anecdotal evidence. The authors conclude by pointing out more research is needed in order to substantiate anecdotal evidence regarding future employment success for IB Diploma Programme graduates.  DOI: 10.18870/hlrc.v4i3.123

  11. Program SITHA. New version of the multigroup system of the neutron cross section GR175-V1

    International Nuclear Information System (INIS)

    Daniehl', A.V.; Perov, V.Yu.; Sokol, E.A.

    1991-01-01

    Structure of the system of the group neutron constants with band description of the resonance field and program system is described. Results of the testing calculations, made by code SITHA, for number of integral experiments devoted to measurements of the neutron flux from H 2 O,C,N,O and Al spherical targets are discussed. 13 refs.; 8 figs.; 1 tab

  12. Implantation and use of a version of the GAMALTA computer code in the 3.500 M Lecroy system

    International Nuclear Information System (INIS)

    Auler, L.T.

    1984-05-01

    The GAMALTA computer code was implanted in the 3.500 M Le Croy system, for creating an optional analysis function which is charged in RAM memory from a discket. The mode to construct functions to make part of the menu of the system is explained and a procedure to use the GAMALTA code is done. (M.C.K.) [pt

  13. Ada Compiler Validation Summary Report: Certificate Number: 940305W1. 11335 TLD Systems, Ltd. TLD Comanche VAX/i960 Ada Compiler System, Version 4.1.1 VAX Cluster under VMS 5.5 = Tronix JIAWG Execution Vehicle (i960MX) under TLD Real Time Executive, Version 4.1.1

    Science.gov (United States)

    1994-03-14

    Comanche VAX/i960 Ada Compiler System, Version 4.1.1 Host Computer System: Digital Local Area Network VAX Cluster executing on (2) MicroVAX 3100 Model 90...31 $MAX DIGITS 15 SmNx INT 2147483647 $MAX INT PLUS_1 2147483648 $MIN IN -2_147483648 A-3 MACR PARAMEERIS $NAME NO SUCH INTEGER TYPE $NAME LIST...nested generlcs are Supported and generics defined in libary units are pexitted. zt is not possible to pen ore a macro instantiation for a generic I

  14. Joint Simulation System (JSIMS) Functional Requirements Document (FRD); A User's Perspective on the Future, Version 1.O

    National Research Council Canada - National Science Library

    1996-01-01

    The purpose of this document is to define JSIMS functional requirements in a level of detail that is meaningful to both the JSIMS developmental community and the expected future users of the system...

  15. Teamwork for Oversight of Processes and Systems (TOPS). Implementation guide for TOPS version 2.0, 10 August 1992

    Science.gov (United States)

    Strand, Albert A.; Jackson, Darryl J.

    1992-01-01

    As the nation redefines priorities to deal with a rapidly changing world order, both government and industry require new approaches for oversight of management systems, particularly for high technology products. Declining defense budgets will lead to significant reductions in government contract management personnel. Concurrently, defense contractors are reducing administrative and overhead staffing to control costs. These combined pressures require bold approaches for the oversight of management systems. In the Spring of 1991, the DPRO and TRW created a Process Action Team (PAT) to jointly prepare a Performance Based Management (PBM) system titled Teamwork for Oversight of Processes and Systems (TOPS). The primary goal is implementation of a performance based management system based on objective data to review critical TRW processes with an emphasis on continuous improvement. The processes are: Finance and Business Systems, Engineering and Manufacturing Systems, Quality Assurance, and Software Systems. The team established a number of goals: delivery of quality products to contractual terms and conditions; ensure that TRW management systems meet government guidance and good business practices; use of objective data to measure critical processes; elimination of wasteful/duplicative reviews and audits; emphasis on teamwork--all efforts must be perceived to add value by both sides and decisions are made by consensus; and synergy and the creation of a strong working trust between TRW and the DPRO. TOPS permits the adjustment of oversight resources when conditions change or when TRW systems performance indicate either an increase or decrease in surveillance is appropriate. Monthly Contractor Performance Assessments (CPA) are derived from a summary of supporting system level and process-level ratings obtained from objective process-level data. Tiered, objective, data-driven metrics are highly successful in achieving a cooperative and effective method of measuring

  16. Teamwork for Oversight of Processes and Systems (TOPS). Implementation guide for TOPS version 2.0, 10 August 1992

    Science.gov (United States)

    Strand, Albert A.; Jackson, Darryl J.

    As the nation redefines priorities to deal with a rapidly changing world order, both government and industry require new approaches for oversight of management systems, particularly for high technology products. Declining defense budgets will lead to significant reductions in government contract management personnel. Concurrently, defense contractors are reducing administrative and overhead staffing to control costs. These combined pressures require bold approaches for the oversight of management systems. In the Spring of 1991, the DPRO and TRW created a Process Action Team (PAT) to jointly prepare a Performance Based Management (PBM) system titled Teamwork for Oversight of Processes and Systems (TOPS). The primary goal is implementation of a performance based management system based on objective data to review critical TRW processes with an emphasis on continuous improvement. The processes are: Finance and Business Systems, Engineering and Manufacturing Systems, Quality Assurance, and Software Systems. The team established a number of goals: delivery of quality products to contractual terms and conditions; ensure that TRW management systems meet government guidance and good business practices; use of objective data to measure critical processes; elimination of wasteful/duplicative reviews and audits; emphasis on teamwork--all efforts must be perceived to add value by both sides and decisions are made by consensus; and synergy and the creation of a strong working trust between TRW and the DPRO. TOPS permits the adjustment of oversight resources when conditions change or when TRW systems performance indicate either an increase or decrease in surveillance is appropriate. Monthly Contractor Performance Assessments (CPA) are derived from a summary of supporting system level and process-level ratings obtained from objective process-level data. Tiered, objective, data-driven metrics are highly successful in achieving a cooperative and effective method of measuring

  17. Tethys: The Marine and Hydrokinetic Technology Environmental Impacts Knowledge Management System -- Requirements Specification -- Version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    Butner, R. Scott; Snowden-Swan, Lesley J.; Ellis, Peter C.

    2010-11-09

    The marine and hydrokinetic (MHK) environmental impacts knowledge management system (KMS), dubbed Tethys after the mythical Greek goddess of the seas, is being developed for the U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy Wind and Hydropower Technologies Program (WHTP) by Pacific Northwest National Laboratory (PNNL). This requirements specification establishes the essential capabilities required of Tethys and clarifies for WHTP and the Tethys development team the results that must be achieved by the system.

  18. Plant expression systems, a budding way to confront chikungunya and Zika in developing countries? [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Jaime A. Cardona-Ospina

    2016-08-01

    Full Text Available Plant expression systems could be used as biofactories of heterologous proteins that have the potential to be used with biopharmaceutical aims and vaccine design. This technology is scalable, safe and cost-effective and it has been previously proposed as an option for vaccine and protein pharmaceutical development in developing countries. Here we present a proposal of how plant expression systems could be used to address Zika and chikungunya outbreaks through development of vaccines and rapid diagnostic kits.

  19. How the Change in IBS Criteria From Rome III to Rome IV Impacts on Clinical Characteristics and Key Pathophysiological Factors.

    Science.gov (United States)

    Aziz, Imran; Törnblom, Hans; Palsson, Olafur S; Whitehead, William E; Simrén, Magnus

    2018-06-08

    The diagnostic criteria for irritable bowel syndrome (IBS) have recently been updated from Rome III to Rome IV. Whereas in Rome III a diagnosis of IBS entailed chronic abdominal pain or discomfort at least 3 days per month, in Rome IV the term discomfort has been removed and the frequency of abdominal pain increased to at least 1 day per week. We examined how this change in IBS criteria impacts on clinical characteristics and pathophysiological factors. A total of 542 Swedish subjects with Rome III IBS completed a baseline questionnaire enquiring for the number of abdominal pain days in the last 10 days; this was subsequently used as a surrogate marker to identify Rome IV IBS, in that (a) those with 0 or 1 day of pain were classed as Rome IV-negative, and (b) those with ≥2 days of pain were classed as Rome IV-positive. Comparisons were made between Rome IV-positive and -negative IBS groups for demographics, IBS subtype, gastrointestinal and psychological symptoms, somatisation, fatigue, disease-specific quality of life, rectal sensitivity, and oro-anal transit time. Overall, 85% of Rome III IBS patients fulfilled the Rome IV criteria for IBS, but 15% did not. Rome IV-positive subjects were significantly more likely to be female, have poorer quality of life, greater pain severity, bloating, somatisation, fatigue, and rectal sensitivity than Rome IV-negative subjects. There were no differences in severity of anxiety or depression, IBS subtypes, bowel habit dissatisfaction, or oro-anal transit time. Finally, increasing number of pain days correlated positively with symptoms and visceral hypersensitivity. Most Rome III-positive IBS patients seeking healthcare fulfil the Rome IV IBS criteria. They constitute a more severe group than those who lose their IBS diagnosis.

  20. [External cephalic version].

    Science.gov (United States)

    Navarro-Santana, B; Duarez-Coronado, M; Plaza-Arranz, J

    2016-08-01

    To analyze the rate of successful external cephalic versions in our center and caesarean sections that would be avoided with the use of external cephalic versions. From January 2012 to March 2016 external cephalic versions carried out at our center, which were a total of 52. We collected data about female age, gestational age at the time of the external cephalic version, maternal body mass index (BMI), fetal variety and situation, fetal weight, parity, location of the placenta, amniotic fluid index (ILA), tocolysis, analgesia, and newborn weight at birth, minor adverse effects (dizziness, hypotension and maternal pain) and major adverse effects (tachycardia, bradycardia, decelerations and emergency cesarean section). 45% of the versions were unsuccessful and 55% were successful. The percentage of successful vaginal delivery in versions was 84% (4% were instrumental) and 15% of caesarean sections. With respect to the variables studied, only significant differences in birth weight were found; suggesting that birth weight it is related to the outcome of external cephalic version. Probably we did not find significant differences due to the number of patients studied. For women with breech presentation, we recommend external cephalic version before the expectant management or performing a cesarean section. The external cephalic version increases the proportion of fetuses in cephalic presentation and also decreases the rate of caesarean sections.