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Sample records for system commonality study

  1. Aging Trajectories in Different Body Systems Share Common Environmental Etiology : The Healthy Aging Twin Study (HATS)

    NARCIS (Netherlands)

    Moayyeri, Alireza; Hart, Deborah J.; Snieder, Harold; Hammond, Christopher J.; Spector, Timothy D.; Steves, Claire J.

    Little is known about the extent to which aging trajectories of different body systems share common sources of variance. We here present a large twin study investigating the trajectories of change in five systems: cardiovascular, respiratory, skeletal, morphometric, and metabolic. Longitudinal

  2. Aging Trajectories in Different Body Systems Share Common Environmental Etiology: The Healthy Aging Twin Study (HATS).

    Science.gov (United States)

    Moayyeri, Alireza; Hart, Deborah J; Snieder, Harold; Hammond, Christopher J; Spector, Timothy D; Steves, Claire J

    2016-02-01

    Little is known about the extent to which aging trajectories of different body systems share common sources of variance. We here present a large twin study investigating the trajectories of change in five systems: cardiovascular, respiratory, skeletal, morphometric, and metabolic. Longitudinal clinical data were collected on 3,508 female twins in the TwinsUK registry (complete pairs:740 monozygotic (MZ), 986 dizygotic (DZ), mean age at entry 48.9 ± 10.4, range 18-75 years; mean follow-up 10.2 ± 2.8 years, range 4-17.8 years). Panel data on multiple age-related variables were used to estimate biological ages for each individual at each time point, in linear mixed effects models. A weighted average approach was used to combine variables within predefined body system groups. Aging trajectories for each system in each individual were then constructed using linear modeling. Multivariate structural equation modeling of these aging trajectories showed low genetic effects (heritability), ranging from 2% in metabolic aging to 22% in cardiovascular aging. However, we found a significant effect of shared environmental factors on the variations in aging trajectories in cardiovascular (54%), skeletal (34%), morphometric (53%), and metabolic systems (53%). The remainder was due to environmental factors unique to each individual plus error. Multivariate Cholesky decomposition showed that among aging trajectories for various body systems there were significant and substantial correlations between the unique environmental latent factors as well as shared environmental factors. However, there was no evidence for a single common factor for aging. This study, the first of its kind in aging, suggests that diverse organ systems share non-genetic sources of variance for aging trajectories. Confirmatory studies are needed using population-based twin cohorts and alternative methods of handling missing data.

  3. Common Submarine Radio Room: A Case Study of a System of Systems Approach

    Science.gov (United States)

    2014-09-01

    circuits at that time required many steps to lineup , providing opportunities for operator error (NUWC 2008, 15). The USS Seawolf (SW) class, designed...The OE-538 antenna group is an improved, multifunctional, combined communications, navigation and Identification Friend or Foe (IFF) mast-mounted... Identification that a number of aeronautical systems did not meet the performance baseline configuration forced a reconfiguration of a number of

  4. Common Systems Integration Lab (CSIL)

    Data.gov (United States)

    Federal Laboratory Consortium — The Common Systems Integration Lab (CSIL)supports the PMA-209 Air Combat Electronics Program Office. CSIL also supports development, test, integration and life cycle...

  5. Are fish immune systems really affected by parasites? an immunoecological study of common carp (Cyprinus carpio

    Directory of Open Access Journals (Sweden)

    Flajšhans Martin

    2011-06-01

    Full Text Available Abstract Background The basic function of the immune system is to protect an organism against infection in order to minimize the fitness costs of being infected. According to life-history theory, energy resources are in a trade-off between the costly demands of immunity and other physiological demands. Concerning fish, both physiology and immunity are influenced by seasonal changes (i.e. temporal variation associated to the changes of abiotic factors (such as primarily water temperature and interactions with pathogens and parasites. In this study, we investigated the potential associations between the physiology and immunocompetence of common carp (Cyprinus carpio collected during five different periods of a given year. Our sampling included the periods with temporal variability and thus, it presented a different level in exposure to parasites. We analyzed which of two factors, seasonality or parasitism, had the strongest impact on changes in fish physiology and immunity. Results We found that seasonal changes play a key role in affecting the analyzed measurements of physiology, immunity and parasitism. The correlation analysis revealed the relationships between the measures of overall host physiology, immunity and parasite load when temporal variability effect was removed. When analyzing separately parasite groups with different life-strategies, we found that fish with a worse condition status were infected more by monogeneans, representing the most abundant parasite group. The high infection by cestodes seems to activate the phagocytes. A weak relationship was found between spleen size and abundance of trematodes when taking into account seasonal changes. Conclusions Even if no direct trade-off between the measures of host immunity and physiology was confirmed when taking into account the seasonality, it seems that seasonal variability affects host immunity and physiology through energy allocation in a trade-off between life important

  6. Common Readout System in ALICE

    CERN Document Server

    Jubin, Mitra

    2016-01-01

    The ALICE experiment at the CERN Large Hadron Collider is going for a major physics upgrade in 2018. This upgrade is necessary for getting high statistics and high precision measurement for probing into rare physics channels needed to understand the dynamics of the condensed phase of QCD. The high interaction rate and the large event size in the upgraded detectors will result in an experimental data flow traffic of about 1 TB/s from the detectors to the on-line computing system. A dedicated Common Readout Unit (CRU) is proposed for data concentration, multiplexing, and trigger distribution. CRU, as common interface unit, handles timing, data and control signals between on-detector systems and online-offline computing system. An overview of the CRU architecture is presented in this manuscript.

  7. Common Readout System in ALICE

    CERN Document Server

    Jubin, Mitra

    2017-01-01

    The ALICE experiment at the CERN Large Hadron Collider is going for a major physics upgrade in 2018. This upgrade is necessary for getting high statistics and high precision measurement for probing into rare physics channels needed to understand the dynamics of the condensed phase of QCD. The high interaction rate and the large event size in the upgraded detectors will result in an experimental data flow traffic of about 1 TB/s from the detectors to the on-line computing system. A dedicated Common Readout Unit (CRU) is proposed for data concentration, multiplexing, and trigger distribution. CRU, as common interface unit, handles timing, data and control signals between on-detector systems and online-offline computing system. An overview of the CRU architecture is presented in this manuscript.

  8. Systemic exertion intolerance disease/chronic fatigue syndrome is common in sleep centre patients with hypersomnolence: A retrospective pilot study.

    Science.gov (United States)

    Maness, Caroline; Saini, Prabhjyot; Bliwise, Donald L; Olvera, Victoria; Rye, David B; Trotti, Lynn M

    2018-04-06

    Symptoms of the central disorders of hypersomnolence extend beyond excessive daytime sleepiness to include non-restorative sleep, fatigue and cognitive dysfunction. They share much in common with myalgic encephalomyelitis/chronic fatigue syndrome, recently renamed systemic exertion intolerance disease, whose additional features include post-exertional malaise and orthostatic intolerance. We sought to determine the frequency and correlates of systemic exertion intolerance disease in a hypersomnolent population. One-hundred and eighty-seven hypersomnolent patients completed questionnaires regarding sleepiness and fatigue; questionnaires and clinical records were used to assess for systemic exertion intolerance disease. Sleep studies, hypocretin and cataplexy were additionally used to assign diagnoses of hypersomnolence disorders or sleep apnea. Included diagnoses were idiopathic hypersomnia (n = 63), narcolepsy type 2 (n = 25), persistent sleepiness after obstructive sleep apnea treatment (n = 25), short habitual sleep duration (n = 41), and sleepiness with normal sleep study (n = 33). Twenty-one percent met systemic exertion intolerance disease criteria, and the frequency of systemic exertion intolerance disease was not different across sleep diagnoses (p = .37). Patients with systemic exertion intolerance disease were no different from those without this diagnosis by gender, age, Epworth Sleepiness Scale, depressive symptoms, or sleep study parameters. The whole cohort reported substantial fatigue on questionnaires, but the systemic exertion intolerance disease group exhibited more profound fatigue and was less likely to respond to traditional wake-promoting agents (88.6% versus 67.7%, p = .01). Systemic exertion intolerance disease appears to be a common co-morbidity in patients with hypersomnolence, which is not specific to hypersomnolence subtype but may portend a poorer prognosis for treatment response. © 2018 European Sleep Research Society.

  9. Common bus multinode sensor system

    International Nuclear Information System (INIS)

    Kelly, T.F.; Naviasky, E.H.; Evans, W.P.; Jefferies, D.W.; Smith, J.R.

    1988-01-01

    This patent describes a nuclear power plant including a common bus multinode sensor system for sensors in the nuclear power plant, each sensor producing a sensor signal. The system consists of: a power supply providing power; a communication cable coupled to the power supply; plural remote sensor units coupled between the cable and one or more sensors, and comprising: a direct current power supply, connected to the cable and converting the power on the cable into direct current; an analog-to-digital converter connected to the direct current power supply; an oscillator reference; a filter; and an integrated circuit sensor interface connected to the direct current power supply, the analog-to-digital converter, the oscillator crystal and the filter, the interface comprising: a counter receiving a frequency designation word from external to the interface; a phase-frequency comparator connected to the counter; an oscillator connected to the oscillator reference; a timing counter connected to the oscillator, the phase/frequency comparator and the analog-to-digital converter; an analog multiplexer connectable to the sensors and the analog-to-digital converter, and connected to the timing counter; a shift register operatively connected to the timing counter and the analog-to-digital converter; an encoder connected to the shift register and connectable to the filter; and a voltage controlled oscillator connected to the filter and the cable

  10. [Evaluation of common commercial systems for the identification of yeast isolates in microbiology laboratories: a multicenter study].

    Science.gov (United States)

    Karabıçak, Nilgün; Uludağ Altun, Hatice; Karatuna, Onur; Hazırolan, Gülşen; Aksu, Neriman; Adiloğlu, Ali; Akyar, Işın

    2015-04-01

    Accurate and rapid identification of yeast isolates have become important in recent years for not only antifungal susceptibility testing due to the species-specific clinical resistance breakpoints but also early initiation of appropriate antifungal therapy. In clinical microbiology laboratories species identification of yeasts is often performed with several commercial systems based on biochemical properties and rarely according to the physiological and morphological characteristics. The aim of this study was to compare the two common commercial systems, VITEK 2 YST ID Card (Vitek; bioMérieux, France) and API 20C AUX (API; bioMérieux, France) with conventional mycological methods. A total of 473 clinical yeast strains isolated from clinical specimens in different university and training/research hospitals and identified by Vitek system were included in the study. The isolates were re-identified with API and conventional methods including morphological identification in the Mycology Reference Laboratory of the Public Health Institute of Turkey. Candida dubliniensis MYA 583, Candida krusei ATCC 6258, Candida parapsilosis ATCC 22019, Candida albicans ATCC 10231 and Cryptococcus neoformans ATCC 32268 were used as quality control strains and those standard strains were studied consecutively 10 days with both of the methods. The results of identification by Vitek and API were compared with the results of conventional methods for those 473 yeast isolates [6 genus (Candida, Cryptococcus, Blastoshizomyces, Rhodotorula, Saccharomyces, Trichosporon), 17 species (5 common and 12 rarely isolated)]. The performances of the systems were better (Vitek: 95%; API: 96%) for the commonly detected species (C.albicans, C.parapsilosis, C.glabrata, C.tropicalis and C.krusei) than those for rarely detected species (Vitek: 78.4%; API: 71.6%) (p= 0.155). Misidentification or unidentification were mostly detected for C.parapsilosis (Vitek: 6/87; API: 7/87) and C.glabrata (Vitek: 9/104; API

  11. Common mode failures in redundancy systems

    International Nuclear Information System (INIS)

    Watson, I.A.; Edwards, G.T.

    1978-01-01

    Difficulties are experienced in assessing the impact of common mode failures on the reliability of safety systems. The paper first covers the investigation, definition and classification of CMF based on an extensive study of the nature of CMF. This is used as a basis for analysing data from nuclear reactor safety systems and aircraft systems. Design and maintenance errors are shown to be the prdominant cause of CMF. The analysis has laid the grounds for work on relating CMF modelling and defences. (author)

  12. Optimizing Safety Stock Levels in Modular Production Systems Using Component Commonality and Group Technology Philosophy: A Study Based on Simulation

    Directory of Open Access Journals (Sweden)

    Kenneth Edgar Hernandez-Ruiz

    2016-01-01

    Full Text Available Modular production and component commonality are two widely used strategies in the manufacturing industry to meet customers growing needs for customized products. Using these strategies, companies can enhance their performance to achieve optimal safety stock levels. Despite the importance of safety stocks in business competition, little attention has been paid to the way to reduce them without affecting the customer service levels. This paper develops a mathematical model to reduce safety stock levels in organizations that employ modular production. To construct the model, we take advantage of the benefits of aggregate inventories, standardization of components, component commonality, and Group Technology philosophy in regard to stock levels. The model is tested through the simulation of three years of operation of two modular product systems. For each system, we calculated and compared the safety stock levels for two cases: (1 under the only presence of component commonality and (2 under the presence of both component commonality and Group Technology philosophy. The results show a reduction in safety stock levels when we linked the component commonality with the Group Technology philosophy. The paper presents a discussion of the implications of each case, features of the model, and suggestions for future research.

  13. A study of common-mode failures

    International Nuclear Information System (INIS)

    Edwards, G.T.; Watson, I.A.

    1979-07-01

    The purpose of the report is to investigate problems of the identification of the common failure mode (CFM) the reliability models used and the data required for their solution, particularly with regard to automatic protection systems for nuclear reactors. The available literature which was surveyed during the study is quoted and used as a basis for the main work of the study. The type of redundancy system under consideration is initially described and the types of CFM to which these systems are prone are identified before a general definition of the term 'common mode failure' is proposed. The definition and proposed classification system for CMF are based on the common cause of failure, so identifying the primary events. Defences against CFM are included and proposals for an overall strategy and detailed recommendations for design and operation are made. Common mode failures in US nuclear reactor systems, aircraft systems, and other sources including chemical plant systems are surveyed. The data indicates the importance of the human error problem in the causes of CMF in design, maintenance and operation. From a study of the collected data a redundancy sub-system model for CMF is developed which identifies three main categories of failure, non-recurrent engineering design errors, maintenance and test errors, and random interest events. The model proposed allows for the improvement in sub-system reliability where appropriate defences are applied. (author)

  14. Common measure of quality of life for people with systemic sclerosis across seven European countries: a cross-sectional study.

    Science.gov (United States)

    Ndosi, Mwidimi; Alcacer-Pitarch, Begonya; Allanore, Yannick; Del Galdo, Francesco; Frerix, Marc; García-Díaz, Sílvia; Hesselstrand, Roger; Kendall, Christine; Matucci-Cerinic, Marco; Mueller-Ladner, Ulf; Sandqvist, Gunnel; Torrente-Segarra, Vicenç; Schmeiser, Tim; Sierakowska, Matylda; Sierakowska, Justyna; Sierakowski, Stanslaw; Redmond, Anthony

    2018-02-20

    The aim of this study was to adapt the Systemic Sclerosis Quality of Life Questionnaire (SScQoL) into six European cultures and validate it as a common measure of quality of life in systemic sclerosis (SSc). This was a seven-country (Germany, France, Italy, Poland, Spain, Sweden and UK) cross-sectional study. A forward-backward translation process was used to adapt the English SScQoL into target languages. SScQoL was completed by patients with SSc, then data were validated against the Rasch model. To correct local response dependency, items were grouped into the following subscales: function, emotion, sleep, social and pain and reanalysed for fit to the model, unidimensionality and cross-cultural equivalence. The adaptation of the SScQoL was seamless in all countries except Germany. Cross-cultural validation included 1080 patients with a mean age 58.0 years (SD 13.9) and 87% were women. Local dependency was evident in individual country data. Grouping items into testlets corrected the local dependency in most country specific data. Fit to the model, reliability and unidimensionality was achieved in six-country data after cross-cultural adjustment for Italy in the social subscale. The SScQoL was then calibrated into an interval level scale. The individual SScQoL items have translated well into five languages and overall, the scale maintained its construct validity, working well as a five-subscale questionnaire. Measures of quality of life in SSc can be directly compared across five countries (France, Poland Spain, Sweden and UK). Data from Italy are also comparable with the other five countries although require an adjustment. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  15. An experimental study of injection and spray characteristics of diesel and gasoline blends on a common rail injection system

    International Nuclear Information System (INIS)

    Han, Dong; Wang, Chunhai; Duan, Yaozong; Tian, Zhisong; Huang, Zhen

    2014-01-01

    The injection and spray characteristics of diesel and gasoline blends are investigated on a common rail injection system. The injection rate, fuel spray evolution process (tip penetration distance, spray cone angle, projected spray area and relative brightness intensity contour) and microscopic droplet features are analyzed. The results show that diesel and gasoline blends have higher volumetric injection rates, earlier starts of injection and shorter injection delays, but little variances are observed in the mass injection rates for different test fuels. Increased gasoline proportion in the test blends causes slightly decreased spray tip penetration distance but increased spray cone angle. Also, more smaller-size droplets are observed in the fuel jet of the diesel and gasoline blends, indicating that the spray breakup and atomization processes are promoted. - Highlights: • Injection rate and spray characteristics of diesel and gasoline blends are studied. • Diesel and gasoline blends have higher volumetric injection rates. • Earlier starts of injection are found when using diesel and gasoline blends. • Diesel and gasoline blends produce shorter spray penetration but higher cone angle. • The number of small droplets increases in the spray of diesel and gasoline blends

  16. Emulation study on system characteristic of high pressure common-rail fuel injection system for marine medium-speed diesel engine

    Science.gov (United States)

    Wang, Qinpeng; Yang, Jianguo; Xin, Dong; He, Yuhai; Yu, Yonghua

    2018-05-01

    In this paper, based on the characteristic analyzing of the mechanical fuel injection system for the marine medium-speed diesel engine, a sectional high-pressure common rail fuel injection system is designed, rated condition rail pressure of which is 160MPa. The system simulation model is built and the performance of the high pressure common rail fuel injection system is analyzed, research results provide the technical foundation for the system engineering development.

  17. Common control system for the CERN accelerators

    International Nuclear Information System (INIS)

    Rausch, R.; Serre, Ch.

    1992-01-01

    The PS and SPS Accelerator Control Systems are becoming obsolete and need urgent rejuvenation. After a control users forum, where users expressed their needs, two main Working Groups were set up, consisting of Control and Equipment Specialists and experienced Machine Operators. One Working Group studied the architecture and the front-end processing and the other a common approach to the application software needed to run the CERN accelerator complex. The paper presents the technical conclusion of their work and the policy to implement it, taking into account the necessity to operate both machines without interruption of the Physics Program. (author)

  18. Open environments to support systems engineering tool integration: A study using the Portable Common Tool Environment (PCTE)

    Science.gov (United States)

    Eckhardt, Dave E., Jr.; Jipping, Michael J.; Wild, Chris J.; Zeil, Steven J.; Roberts, Cathy C.

    1993-01-01

    A study of computer engineering tool integration using the Portable Common Tool Environment (PCTE) Public Interface Standard is presented. Over a 10-week time frame, three existing software products were encapsulated to work in the Emeraude environment, an implementation of the PCTE version 1.5 standard. The software products used were a computer-aided software engineering (CASE) design tool, a software reuse tool, and a computer architecture design and analysis tool. The tool set was then demonstrated to work in a coordinated design process in the Emeraude environment. The project and the features of PCTE used are described, experience with the use of Emeraude environment over the project time frame is summarized, and several related areas for future research are summarized.

  19. A Study of Spill Control Characteristics of JP-8 and Conventional Diesel Fuel with a Common Rail Direct Injection System

    Directory of Open Access Journals (Sweden)

    Seomoon Yang

    2017-12-01

    Full Text Available Diversification of energy sources is a key task for decreasing environmental impacts and global emission of gases. JP-8, a fuel derived from natural gas, coal, biomass, and waste plastics, is a bright prospect. JP-8 is considered a multi-source multi-purpose fuel, with several applications. A preliminary characterization of the JP-8 injection rate and injection quantity behavior was investigated based on the high-pressure common rail injection system used in a heavy-duty engine. According to the spill injection and injection pressure, a trade-off trend between injection rate and injection quantity was observed. As expected, pilot injection of JP-8 aviation fuel and diesel fuel affects the spray quantity and injection evolution of the subsequent operation without pilot injection. The difference in spilling between diesel and JP-8 aviation fuel is greater than the difference in injection amount per time; in the process of controlling the injector solenoid through ECU (Electric Control Units, the oil pressure valve and the needle valve operate to a higher extent in order to maintain the diesel fuel’s injection quantity volume. It was found that the total injection quantity was decreased by adding 20% pilot injection duration. Because the pilot injection quantity causes solenoid response, loss and needle lift stroke friction loss.

  20. CMLOG: A common message logging system

    International Nuclear Information System (INIS)

    Chen, J.; Akers, W.; Bickley, M.; Wu, D.; Watson, W. III

    1997-01-01

    The Common Message Logging (CMLOG) system is an object-oriented and distributed system that not only allows applications and systems to log data (messages) of any type into a centralized database but also lets applications view incoming messages in real-time or retrieve stored data from the database according to selection rules. It consists of a concurrent Unix server that handles incoming logging or searching messages, a Motif browser that can view incoming messages in real-time or display stored data in the database, a client daemon that buffers and sends logging messages to the server, and libraries that can be used by applications to send data to or retrieve data from the database via the server. This paper presents the design and implementation of the CMLOG system meanwhile it will also address the issue of integration of CMLOG into existing control systems. CMLOG into existing control systems

  1. Study of the Atucha I nuclear power plant's residual heat removal system unavailability through the fault tree analysis and common cause failures

    International Nuclear Information System (INIS)

    Terrado, C.A.

    1991-06-01

    The present essay offers a comprehensive research of the Atucha I nuclear power plant's residual heat removal system unavailability, including Fault Tree Analysis and Common Cause Failures (CCF) treatment. The study is developed within the Event Tree perspective that considers the loss of external electrical power of the initiating event. The event was constructed by the Safety Evaluations Division of the Ezeiza Atomic Center in Argentina. According to the Event Tree, the research includes system demand during plant operation with 132 KV and emergency generation (Diesel motor generators). The system unavailability assessment is approached in two different ways: a) Considering independent failures only. b) Taking into account the existence of Common Cause Events, and modeling dependent failures. The Fault Tree quantification is played using the AIEA PSAPACK Code. The assessment data base is compiled from plant specific records and generic data bases like TECDOC 478. After Fault Tree model logic development, some general procedures used in common cause failures treating are applied to pick up another set of solutions. The results of the study are: a) Four Fault Trees have been developed to model the abovementioned system: 132 KV and emergency generation, both including and excluding CCF. b) The following unavailability values were obtained: 132 KV independent failures only: 7 10 -4 . Emergency generation independent failures only: 1.53 10 -2 . 132 KV dependent and independent failures: 3.6 10 -3 . Emergency generation dependent and independent failures: 1.74 10 -2 . The major conclusions obtained from the precedent results are: a) When using 132 KV system configuration, minimal cut sets involving common cause failures represents 81%from total system unavailability. b) The dependent failures treatment is an important task to be considered in safety assessments in order to reach more realistic values. (Author) [es

  2. Common occupational classification system - revision 3

    Energy Technology Data Exchange (ETDEWEB)

    Stahlman, E.J.; Lewis, R.E.

    1996-05-01

    Workforce planning has become an increasing concern within the DOE community as the Office of Environmental Restoration and Waste Management (ER/WM or EM) seeks to consolidate and refocus its activities and the Office of Defense Programs (DP) closes production sites. Attempts to manage the growth and skills mix of the EM workforce while retaining the critical skills of the DP workforce have been difficult due to the lack of a consistent set of occupational titles and definitions across the complex. Two reasons for this difficulty may be cited. First, classification systems commonly used in industry often fail to cover in sufficient depth the unique demands of DOE`s nuclear energy and research community. Second, the government practice of contracting the operation of government facilities to the private sector has introduced numerous contractor-specific classification schemes to the DOE complex. As a result, sites/contractors report their workforce needs using unique classification systems. It becomes difficult, therefore, to roll these data up to the national level necessary to support strategic planning and analysis. The Common Occupational Classification System (COCS) is designed to overcome these workforce planning barriers. The COCS is based on earlier workforce planning activities and the input of technical, workforce planning, and human resource managers from across the DOE complex. It provides a set of mutually-exclusive occupation titles and definitions that cover the broad range of activities present in the DOE complex. The COCS is not a required record-keeping or data management guide. Neither is it intended to replace contractor/DOE-specific classification systems. Instead, the system provides a consistent, high- level, functional structure of occupations to which contractors can crosswalk (map) their job titles.

  3. KEAGENAN BANK DALAM PERSPEKTIF COMMON LAW SYSTEM

    Directory of Open Access Journals (Sweden)

    Andika Persada Putera

    2017-05-01

    Full Text Available The rapid development of the national economy and banking external environment, causing banking activities not only engage in activities that are primary (core business, but also non-core business such as agency activities as Mutual Fund Sales Agent (APERD and Bancassurance. In the concept of the common law system, the agency as the center of all business affairs as a business owner can not do your own business, so delegating affairs to agents as a mediator. There is a legal relationships and trust (fiduciary relationship between the principal and the agent acting on behalf principal. In addition, there is an element of supervision of the principal to the agent so that the agent must comply under the supervision of the principal. Supervision is an essential element that determines the existence of an agency relationship, so it is a vertical relationship between principal and agent. The principal control components in the form of action directives, orders, limitation of power agents and monitoring the agent's action.

  4. Common cause failure analysis methodology for complex systems

    International Nuclear Information System (INIS)

    Wagner, D.P.; Cate, C.L.; Fussell, J.B.

    1977-01-01

    Common cause failure analysis, also called common mode failure analysis, is an integral part of a complex system reliability analysis. This paper extends existing methods of computer aided common cause failure analysis by allowing analysis of the complex systems often encountered in practice. The methods presented here aid in identifying potential common cause failures and also address quantitative common cause failure analysis

  5. Common Group Problems: A Field Study.

    Science.gov (United States)

    Weinberg, Sanford B.; And Others

    1981-01-01

    A field study of a naturally functioning group (N=125) was conducted to identify common group problems. Trained observers attended group meetings and described the problems encountered. Difficulties of cohesion, leadership, sub-group formation, and personality conflict were identified. (RC)

  6. Investigations of inter-system common cause failures

    International Nuclear Information System (INIS)

    Nonclerca, P.; Gallois, M.; Vasseur, D.

    2012-01-01

    Intra-system common-cause failures (CCF) are widely studied and addressed in existing PSA models, but the information and studies that incorporate the potential for inter-system CCF is limited. However, the French Safety Authority has requested that EDF investigate the possibility of common-cause failure across system boundaries for Flamanville 3 (an EPR design). Also, the modeling of inter-system CCF, or the proof that their impact is negligible, would satisfy Capability Category III for one of the requirements in the ASME/ANS PRA standard in the U.S. EDF and EPRI have been working on a method to assess when it is necessary to take into account inter-system CCF in a PSA model between 2008 and 2010. This method is based both on the likelihood of inter-system CCF and on its demonstrated potential impact on CDF (core damage frequency). This method was first applied on pumps in different systems of the 900 MWe series plants. The second application concerned the motor-operated valves across different systems, using the same PSA model. This second application helped us refine the method, which was not optimal when the number of concerned components is very large. Since then, the method has been successfully applied on the pumps and 10 kV breakers of the EPR power plant in Flamanville. This paper describes the method and the results obtained in some of these studies. All studies have shown either that components in different systems, when they were not already part of a common cause failure group in the model, are not susceptible to common causes of failure, or that the potential for inter-system common-cause failure is negligible regarding the overall risk. (authors)

  7. TOP TAX SYSTEM - A common tax system for all nations

    OpenAIRE

    VIJAYA KRUSHNA VARMA

    2011-01-01

    TOP Tax system is a new tax system which can be used as a common tax system for all nations. This new tax system will be without present tax system’s all Direct and Indirect taxes accompanied by tax laws, tax exemptions, multiple tax collection departments to relieve 7 billion people of the world from the cobweb of ambiguous and complex tax structures, plethora of tax laws, mandatory and cumbersome accounting, auditing, tax returns and consequent quagmire of all tax related cases. Taxation, t...

  8. Pressure-amplified Common Rail System for commercial vehicles; Druckuebersetztes Common-Rail-System fuer Nutzfahrzeuge

    Energy Technology Data Exchange (ETDEWEB)

    Leonhard, Rolf; Parche, Marcus; Alvarez-Avila, Carlos [Bosch AG, Stuttgart (Germany). Diesel Systems; Krauss, Jost; Rosenau, Bernd [Bosch AG, Stuttgart (Germany). Common-Rail-Systeme

    2009-05-15

    The key to a successful layout of a combustion system for commercial vehicles is in the management of peak torque operation points. For this purpose, Bosch has enhanced its Common Rail System with increasing degrees of freedom - i.e. with flexible rate shaping. A second solenoid valve activates a pressure-amplifier inside the injector, an optimized offset of nozzle needle timing reduces the injection rate by half right at the start of injection, and the formation of nitrogen oxide is reduced considerably. This enables the engine manufacturer to adhere to the emission limits while further reducing fuel consumption and the engine-related effort for the air sytem. (orig.)

  9. Importance of Applying Condiments in a Commonly Consumed Food System for Understanding the Association Between Familiarity and Sensory Drivers of Liking: A Study Focused on Doenjang.

    Science.gov (United States)

    Roh, Soo Hyun; Lee, Soh Min; Kim, Sang Sook; Kim, Kwang-Ok

    2018-02-01

    Doenjang, a Korean traditional fermented soybean paste, is one of the most essential condiments in Korean cuisine. Condiments are rarely consumed as it is, and are generally applied to other foods. The objective of this study was to understand how sensory drivers of liking of Doenjang would be affected according to food forms in which it is evaluated: the original paste form compared with a normally consumed soup form, and to understand the association of familiarity of evaluated food form. Descriptive analysis and consumer acceptability test was performed in 2 consumption forms: the original paste form and the Doenjang soup from. For consumer liking test, elderly consumers who have more experience to traditional Deonjang were compared to the young in their response to Doenjang paste and soup. The descriptive analysis results showed that the characteristic sensory features of the Deonjang samples were little affected based on the food system in which it was evaluated. However, when the paste was applied in soup, the intensities of the characteristic sensory features were reduced. Acceptability and familiarity of traditional type Doenjang samples for the young and for the elderly consumers were very similar in paste, but it differed when the samples were evaluated in soup. Thus, expectation difference between the young and the elderly was better revealed in soup, a more common food form consumed in practice. The results of this study indicate the importance of understanding sensory drivers of liking for a condiment such as Doenjang in their commonly consumed forms. Compared to the original condiment form, expectation difference between the young and the elderly were better revealed in Deonjang soup, a food form normally consumed in practice. Thus, the results of this study reinforced the importance of investigating sensory drivers of liking for a condiment in a food form that is normally consumed in practice for accurate understanding on consumer preference. © 2018

  10. Common cause failure investigations using the European Reliability Data System

    International Nuclear Information System (INIS)

    Games, A.M.; Breewood, M.; Amendola, A.; Keller, A.Z.

    1984-01-01

    The European Reliability Data System (ERDS) has provided data for use in investigations into common cause failures (CCFs) in nuclear power plants. These investigations have been made on two levels, at a system and inter-system level. Data have been used from the Component Event Data Bank and from the Licensee Event Report Files, both part of the ERDS. The two studies required different methodologies although both commenced with a temporal sorting procedure for the failure events. The studies demonstrated that different types of common cause failure necessitate different search algorithms, and thus a data search must be closely related to an appropriate CCF classification system, which in the first instance would not be based on causes of failure. (author)

  11. Importance analysis for the systems with common cause failures

    International Nuclear Information System (INIS)

    Pan Zhijie; Nonaka, Yasuo

    1995-01-01

    This paper extends the importance analysis technique to the research field of common cause failures to evaluate the structure importance, probability importance, and β-importance for the systems with common cause failures. These importance measures would help reliability analysts to limit the common cause failure analysis framework and find efficient defence strategies against common cause failures

  12. Electoral Offenses in The Common Law System

    Directory of Open Access Journals (Sweden)

    Vladimir Mulaj

    2013-07-01

    Full Text Available Electoral behavior is a new element in the political analysis of democracy in Albania. Distinctive features of the Albanian transition distinguish other models of the former communist countries, as well as significantly differ with Western models and electoral behavior analysis of the relations between political actors and citizens voting. Penal Code of the Republic of Albania remains the basis of criminal law to sanction criminal acts in the election. The object of criminal misconduct are directly related to the normal criminal and legal protection and free elections as well as the Albanian Constitution provides all these obstacles to electoral subjects committed by force or by any other means which directly affect the normal performance electoral system. Barriers can be done with physical or psychological, and consists in blocking commissioners election materials, election materials decay affecting decay electoral system unfairly supported a particular political party or a coalition of political parties that present list candidacy according to the rules defined in the electoral code. Albanian Constitution as the fundamental law of the Albanian state provides for the rightness of the equality of the vote for all Albanian citizens The vote is the democratic way that every citizen expressing the opinion and its political will but to have democratic value ratings should be personal equal, free and secret. The right to vote is a political right provided by the Albanian Constitution and the Universal Declaration of Human Rights and as such is closely linked to democracy, the sovereignty of the people and citizens. Total vote, or the right to get to the polls all Albanian citizens, men and women, and in fact is the greatest achievement of the twentieth century. According to the Electoral Code of the Republic of Albania every citizen exercises his right to vote at his polling station, where placed under citizen’s location criteria. Voting centers

  13. Common characterization of variability and forecast errors of variable energy sources and their mitigation using reserves in power system integration studies

    Energy Technology Data Exchange (ETDEWEB)

    Menemenlis, N.; Huneault, M. [IREQ, Varennes, QC (Canada); Robitaille, A. [Dir. Plantif. de la Production Eolienne, Montreal, QC (Canada). HQ Production; Holttinen, H. [VTT Technical Research Centre of Finland, VTT (Finland)

    2012-07-01

    This In this paper we define and characterize the two random variables, variability and forecast error, over which uncertainty in power systems operations is characterized and mitigated. We show that the characterization of both these variables can be carried out with the same mathematical tools. Furthermore, this common characterization of random variables lends itself to a common methodology for the calculation of non-contingency reserves required to mitigate their effects. A parallel comparison of these two variables demonstrates similar inherent statistical properties. They depend on imminent conditions, evolve with time and can be asymmetric. Correlation is an important factor when aggregating individual wind farm characteristics in forming the distribution of the total wind generation for imminent conditions. (orig.)

  14. Software Defined Common Processing System (SDCPS), Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Coherent Logix, Incorporated proposes the Software Defined Common Processing System (SDCPS) program to facilitate the development of a Software Defined Radio...

  15. Software Defined Common Processing System (SDCPS), Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Coherent Logix, Incorporated (CLX) proposes the development of a Software Defined Common Processing System (SDCPS) that leverages the inherent advantages of an...

  16. Common Operating Picture: UAV Security Study

    Science.gov (United States)

    2004-01-01

    This initial communication security study is a top-level assessment of basic security issues related to the operation of Unmanned Aerial Vehicles (UAVs) in the National Airspace System (NAS). Security considerations will include information relating to the use of International Civil Aviation Organization (ICAO) Aeronautical Telecommunications Network (ATN) protocols and applications identifying their maturity, as well as the use of IPV4 and a version of mobile IPV6. The purpose of this assessment is to provide an initial analysis of the security implications of introducing UAVs into the NAS.

  17. Defense against common-mode failures in protection system design

    International Nuclear Information System (INIS)

    Wyman, R.H.; Johnson, G.L.

    1998-01-01

    The introduction of digital instrumentation and control into reactor safety systems creates a heightened concern about common-mode failure. This paper discusses the concern and methods of cope with the concern. Common-mode failures have been a 'fact-of-life' in existing systems. The informal introduction of defense-in-depth and diversity (D-in-D and D) - coupled with the fact that hardware common-mode failures are often distributed in time - has allowed systems to deal with past common-mode failures. However, identical software operating in identical redundant systems presents the potential for simultaneous failure. Consequently, the use of digital systems raises the concern about common-mode failure to a new level. A more methodical approach to mitigating common-mode failure is needed to address these concerns. Purposeful introduction of D-in-D and D has been used as a defense against common-mode failure in reactor protection systems. At least two diverse systems are provided to mitigate any potential initiating event. Additionally, diverse displays and controls are provided to allow the operator to monitor plant status and manually initiate engineered safety features. A special form of common-mode failure analysis called 'defense-in-depth and diversity analysis' has been developed to identify possible common-mode failure vulnerabilities in digital systems. An overview of this analysis technique is provided. (author)

  18. Study on the standard architecture for geoinformation common services

    Science.gov (United States)

    Zha, Z.; Zhang, L.; Wang, C.; Jiang, J.; Huang, W.

    2014-04-01

    The construction of platform for geoinformation common services was completed or on going in in most provinces and cities in these years in China, and the platforms plays an important role in the economic and social activities. Geoinfromation and geoinfromation based services are the key issues in the platform. The standards on geoinormation common services play as bridges among the users, systems and designers of the platform. The standard architecture for geoinformation common services is the guideline for designing and using the standard system in which the standards integrated to each other to promote the development, sharing and services of geoinformation resources. To establish the standard architecture for geoinformation common services is one of the tasks of "Study on important standards for geonformation common services and management of public facilities in city". The scope of the standard architecture is defined, such as data or information model, interoperability interface or service, information management. Some Research work on the status of international standards of geoinormation common services in organization and countries, like ISO/TC 211, OGC and other countries or unions like USA, EU, Japan have done. Some principles are set up to evaluate the standard, such as availability, suitability and extensible ability. Then the development requirement and practical situation are analyzed, and a framework of the standard architecture for geoinformation common services are proposed. Finally, a summary and prospects of the geoinformation standards are made.

  19. Evidence for a common mucosal immune system in the pig.

    Science.gov (United States)

    Wilson, Heather L; Obradovic, Milan R

    2015-07-01

    The majority of lymphocytes activated at mucosal sites receive instructions to home back to the local mucosa, but a portion also seed distal mucosa sites. By seeding distal sites with antigen-specific effector or memory lymphocytes, the foundation is laid for the animal's mucosal immune system to respond with a secondary response should to this antigen be encountered at this site in the future. The common mucosal immune system has been studied quite extensively in rodent models but less so in large animal models such as the pig. Reasons for this paucity of reported induction of the common mucosal immune system in this species may be that distal mucosal sites were examined but no induction was observed and therefore it was not reported. However, we suspect that the majority of investigators simply did not sample distal mucosal sites and therefore there is little evidence of immune response induction in the literature. It is our hope that more pig immunologists and infectious disease experts who perform mucosal immunizations or inoculations on pigs will sample distal mucosal sites and report their findings, whether results are positive or negative. In this review, we highlight papers that show that immunization/inoculation using one route triggers mucosal immune system induction locally, systemically, and within at least one distal mucosal site. Only by understanding whether immunizations at one site triggers immunity throughout the common mucosal immune system can we rationally develop vaccines for the pig, and through these works we can gather evidence about the mucosal immune system that may be extrapolated to other livestock species or humans. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Genetics in psychiatry: common variant association studies

    Directory of Open Access Journals (Sweden)

    Buxbaum Joseph D

    2010-03-01

    Full Text Available Abstract Many psychiatric conditions and traits are associated with significant heritability. Genetic risk for psychiatric conditions encompass rare variants, identified due to major effect, as well as common variants, the latter analyzed by association analyses. We review guidelines for common variant association analyses, undertaking after assessing evidence of heritability. We highlight the importance of: suitably large sample sizes; an experimental design that controls for ancestry; careful data cleaning; correction for multiple testing; small P values for positive findings; assessment of effect size for positive findings; and, inclusion of an independent replication sample. We also note the importance of a critical discussion of any prior findings, biological follow-up where possible, and a means of accessing the raw data.

  1. Defense against common-mode failures in protection system design

    International Nuclear Information System (INIS)

    Wyman, R.H.; Johnson, G.L.

    1997-01-01

    The introduction of digital instrumentation and control into reactor safety systems creates a heightened concern about common-mode failure. This paper discusses the concern and methods to cope with the concern. Common-mode failures have been a ''fact-of-life'' in existing systems. The informal introduction of defense-in-depth and diversity (D-in-D ampersand D)-coupled with the fact that hardware common-mode failures are often distributed in time-has allowed systems to deal with past common-mode failures. However, identical software operating in identical redundant systems presents the potential for simultaneous failure. Consequently, the use of digital systems raises the concern about common-mode failure to a new level. A more methodical approach to mitigating common-mode failure is needed to address these concerns. Purposeful introduction of D-in-D ampersand D has been used as a defense against common-mode failure in reactor protection systems. At least two diverse systems are provided to mitigate any potential initiating event. Additionally, diverse displays and controls are provided to allow the operator to monitor plant status and manually initiate engineered safety features. A special form of conimon-mode failure analysis called ''defense-in-depth and diversity analysis'' has been developed to identify possible conimon-mode failure vulnerabilities in digital systems. An overview of this analysis technique is provided

  2. Common Cause Failure Analysis for the Digital Plant Protection System

    International Nuclear Information System (INIS)

    Kagn, Hyun Gook; Jang, Seung Cheol

    2005-01-01

    Safety-critical systems such as nuclear power plants adopt the multiple-redundancy design in order to reduce the risk from the single component failure. The digitalized safety-signal generation system is also designed based on the multiple-redundancy strategy which consists of more redundant components. The level of the redundant design of digital systems is usually higher than those of conventional mechanical systems. This higher redundancy would clearly reduce the risk from the single failure of components, but raise the importance of the common cause failure (CCF) analysis. This research aims to develop the practical and realistic method for modeling the CCF in digital safety-critical systems. We propose a simple and practical framework for assessing the CCF probability of digital equipment. Higher level of redundancy causes the difficulty of CCF analysis because it results in impractically large number of CCF events in the fault tree model when we use conventional CCF modeling methods. We apply the simplified alpha-factor (SAF) method to the digital system CCF analysis. The precedent study has shown that SAF method is quite realistic but simple when we consider carefully system success criteria. The first step for using the SAF method is the analysis of target system for determining the function failure cases. That is, the success criteria of the system could be derived from the target system's function and configuration. Based on this analysis, we can calculate the probability of single CCF event which represents the CCF events resulting in the system failure. In addition to the application of SAF method, in order to accommodate the other characteristics of digital technology, we develop a simple concept and several equations for practical use

  3. Basic concept of common reactor physics code systems. Final report of working party on common reactor physics code systems (CCS)

    International Nuclear Information System (INIS)

    2004-03-01

    A working party was organized for two years (2001-2002) on common reactor physics code systems under the Research Committee on Reactor Physics of JAERI. This final report is compilation of activity of the working party on common reactor physics code systems during two years. Objectives of the working party is to clarify basic concept of common reactor physics code systems to improve convenience of reactor physics code systems for reactor physics researchers in Japan on their various field of research and development activities. We have held four meetings during 2 years, investigated status of reactor physics code systems and innovative software technologies, and discussed basic concept of common reactor physics code systems. (author)

  4. High pressure common rail injection system modeling and control.

    Science.gov (United States)

    Wang, H P; Zheng, D; Tian, Y

    2016-07-01

    In this paper modeling and common-rail pressure control of high pressure common rail injection system (HPCRIS) is presented. The proposed mathematical model of high pressure common rail injection system which contains three sub-systems: high pressure pump sub-model, common rail sub-model and injector sub-model is a relative complicated nonlinear system. The mathematical model is validated by the software Matlab and a virtual detailed simulation environment. For the considered HPCRIS, an effective model free controller which is called Extended State Observer - based intelligent Proportional Integral (ESO-based iPI) controller is designed. And this proposed method is composed mainly of the referred ESO observer, and a time delay estimation based iPI controller. Finally, to demonstrate the performances of the proposed controller, the proposed ESO-based iPI controller is compared with a conventional PID controller and ADRC. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

  5. [Development of expert diagnostic system for common respiratory diseases].

    Science.gov (United States)

    Xu, Wei-hua; Chen, You-ling; Yan, Zheng

    2014-03-01

    To develop an internet-based expert diagnostic system for common respiratory diseases. SaaS system was used to build architecture; pattern of forward reasoning was applied for inference engine design; ASP.NET with C# from the tool pack of Microsoft Visual Studio 2005 was used for website-interview medical expert system.The database of the system was constructed with Microsoft SQL Server 2005. The developed expert system contained large data memory and high efficient function of data interview and data analysis for diagnosis of various diseases.The users were able to perform this system to obtain diagnosis for common respiratory diseases via internet. The developed expert system may be used for internet-based diagnosis of various respiratory diseases,particularly in telemedicine setting.

  6. Reliability model for common mode failures in redundant safety systems

    International Nuclear Information System (INIS)

    Fleming, K.N.

    1974-12-01

    A method is presented for computing the reliability of redundant safety systems, considering both independent and common mode type failures. The model developed for the computation is a simple extension of classical reliability theory. The feasibility of the method is demonstrated with the use of an example. The probability of failure of a typical diesel-generator emergency power system is computed based on data obtained from U. S. diesel-generator operating experience. The results are compared with reliability predictions based on the assumption that all failures are independent. The comparison shows a significant increase in the probability of redundant system failure, when common failure modes are considered. (U.S.)

  7. The electric commons: A qualitative study of community accountability

    International Nuclear Information System (INIS)

    Melville, Emilia; Christie, Ian; Burningham, Kate; Way, Celia; Hampshire, Phil

    2017-01-01

    This study explores how energy might be conceptualised as a commons, a resource owned and managed by a community with a system of rules for production and consumption. It tests one aspect of Elinor Ostrom's design principles for successful management of common pool resources: that there should be community accountability for individual consumption behaviour. This is explored through interviews with participants in a community demand response (DR) trial in an urban neighbourhood in the UK. Domestic DR can make a contribution to balancing electricity supply and demand. This relies on smart meters, which raise vertical (individual to large organisation) privacy concerns. Community and local approaches could motivate greater levels of DR than price signals alone. We found that acting as part of a community is motivating, a conclusion which supports local and community based roll out of smart meters. Mutually supportive, voluntary, and anonymous sharing of information was welcomed. However, mutual monitoring was seen as an invasion of horizontal (peer to peer) privacy. We conclude that the research agenda, which asks whether local commons-based governance of electricity systems could provide social and environmental benefits, is worth pursuing further. This needs a shift in regulatory barriers and ‘governance-system neutral’ innovation funding. - Highlights: • Commons framings can offer a new perspective on community based demand response. • Community accountability of users raises concerns about horizontal (within community) privacy. • Horizontal privacy is important to individuals, and should be protected. • Supportive sharing of information is welcomed. • Energy policy should enable institutional innovation including local commons based approaches.

  8. Top tax system: a common taxation system for all nations

    OpenAIRE

    Varma, Vijaya Krushna Varma

    2009-01-01

    I am suggesting new methods, and innovative and alternative policies in the areas of optimal taxation, tax collection, money supply and banking financial system to help remove corruption, tax evasion, economic recession, black money, fake currency and societal inequalities. In my opinion, the proposed TOP Tax system may usher in good governance, 100% tax compliance and corruption free environment. It suggests a single tax called “TOP Tax” (Transfer Or Purchase Tax) for both Centre and States ...

  9. Joint Service Common Operating Environment (COE) Common Geographic Information System functional requirements

    Energy Technology Data Exchange (ETDEWEB)

    Meitzler, W.D.

    1992-06-01

    In the context of this document and COE, the Geographic Information Systems (GIS) are decision support systems involving the integration of spatially referenced data in a problem solving environment. They are digital computer systems for capturing, processing, managing, displaying, modeling, and analyzing geographically referenced spatial data which are described by attribute data and location. The ability to perform spatial analysis and the ability to combine two or more data sets to create new spatial information differentiates a GIS from other computer mapping systems. While the CCGIS allows for data editing and input, its primary purpose is not to prepare data, but rather to manipulate, analyte, and clarify it. The CCGIS defined herein provides GIS services and resources including the spatial and map related functionality common to all subsystems contained within the COE suite of C4I systems. The CCGIS, which is an integral component of the COE concept, relies on the other COE standard components to provide the definition for other support computing services required.

  10. Common cause analysis of the TREAT upgrade reactor protection system

    Energy Technology Data Exchange (ETDEWEB)

    Page, R.J.; Kamis, G.J.; Marbach, R.A.; Mueller, C.J.

    1984-09-01

    A triply redundant reactor scram system (RSS) has been designed for the upgraded TREAT facility. The independent failures reliability goal for the RSS is <10/sup -9/ failures per demand. An independent failures analysis indicated that this goal would be met. In addition, however, recognizing that in heavily redundant systems common-cause failures dominate, a common cause analysis of the TREAT upgrade RSS was done. The objective was to identify those common-cause initiators which could affect the functioning of the RSS, and to subsequently modify the design of the RSS so that the effect was minimized. A number of common-cause initiators were identified which were capable of defeating the triple redundancy feature of the reactor scram system. By means of a systematic analysis of the effect these initiators could have on the system, it was possible to identify seven necessary design and procedural modifications that would greatly reduce the probability of the reactor being run while the RSS was in a faulted condition.

  11. A Common Definition of the System Operators' Core Activities

    International Nuclear Information System (INIS)

    2006-02-01

    In this report a common definition of the system operator's core activities in the Nordic countries is identified and also a list of non-core activities is introduced. As a starting point the common tasks for system responsibility as identified by Nordel has been used for the work. The term TSO (Transmission System Operator) is employed as a common denominator in the report. It is found out that the TSOs carry out common core activities in the roles as a transmission operator, a system operator and a balance settlement responsible. The core activities for the TSO as a transmission network operator are: Maintain the adequate transmission system in the long run and network development plan on the national as well as on the Nordic level using sophisticated analysis and planning methods and tools. Plan the transmission network on the national as well as on the Nordic level utilising new investments, renewal and maintenance of existing network components so that the network is secure to operate and adequate transmission capacity is guaranteed. Aim at timely network expansions using enhanced information exchange between the Nordic TSOs, and on the national level between the TSO and distribution and regional network operators, large consumers and large producers. Secure the technical compatibility with networks across the border and within a country by establishing connection requirements on the national level and ensuring that the national requirements are compatible across the Nordic power system. The core activities for the TSO as a system operator are: Define common technical requirements for the secure system operation using common planning, operation, connection and data exchange procedures. Secure the system operation with the operational planning for the following year by using information exchange between TSOs enabling the TSOs to make the best possible forecast of the global grid situation in order to assess the flows in their network and the available

  12. A common type system for clinical natural language processing

    Directory of Open Access Journals (Sweden)

    Wu Stephen T

    2013-01-01

    Full Text Available Abstract Background One challenge in reusing clinical data stored in electronic medical records is that these data are heterogenous. Clinical Natural Language Processing (NLP plays an important role in transforming information in clinical text to a standard representation that is comparable and interoperable. Information may be processed and shared when a type system specifies the allowable data structures. Therefore, we aim to define a common type system for clinical NLP that enables interoperability between structured and unstructured data generated in different clinical settings. Results We describe a common type system for clinical NLP that has an end target of deep semantics based on Clinical Element Models (CEMs, thus interoperating with structured data and accommodating diverse NLP approaches. The type system has been implemented in UIMA (Unstructured Information Management Architecture and is fully functional in a popular open-source clinical NLP system, cTAKES (clinical Text Analysis and Knowledge Extraction System versions 2.0 and later. Conclusions We have created a type system that targets deep semantics, thereby allowing for NLP systems to encapsulate knowledge from text and share it alongside heterogenous clinical data sources. Rather than surface semantics that are typically the end product of NLP algorithms, CEM-based semantics explicitly build in deep clinical semantics as the point of interoperability with more structured data types.

  13. A common type system for clinical natural language processing.

    Science.gov (United States)

    Wu, Stephen T; Kaggal, Vinod C; Dligach, Dmitriy; Masanz, James J; Chen, Pei; Becker, Lee; Chapman, Wendy W; Savova, Guergana K; Liu, Hongfang; Chute, Christopher G

    2013-01-03

    One challenge in reusing clinical data stored in electronic medical records is that these data are heterogenous. Clinical Natural Language Processing (NLP) plays an important role in transforming information in clinical text to a standard representation that is comparable and interoperable. Information may be processed and shared when a type system specifies the allowable data structures. Therefore, we aim to define a common type system for clinical NLP that enables interoperability between structured and unstructured data generated in different clinical settings. We describe a common type system for clinical NLP that has an end target of deep semantics based on Clinical Element Models (CEMs), thus interoperating with structured data and accommodating diverse NLP approaches. The type system has been implemented in UIMA (Unstructured Information Management Architecture) and is fully functional in a popular open-source clinical NLP system, cTAKES (clinical Text Analysis and Knowledge Extraction System) versions 2.0 and later. We have created a type system that targets deep semantics, thereby allowing for NLP systems to encapsulate knowledge from text and share it alongside heterogenous clinical data sources. Rather than surface semantics that are typically the end product of NLP algorithms, CEM-based semantics explicitly build in deep clinical semantics as the point of interoperability with more structured data types.

  14. The male reproductive system - An overview of common problems.

    Science.gov (United States)

    Wijesinha, Sanjiva; Piterman, Leon; Kirby, Catherine N

    2013-05-01

    Many male reproductive system problems could be perceived as being embarrassing, which may be one of the reasons that they are often not identified in general practice. This article provides an overview of some common problems affecting the male reproductive system, and outlines current treatment options. Erectile dysfunction, premature ejaculation, loss of libido, testicular cancer and prostate disease may cause embarrassment to the patient and, occasionally, the general practitioner. We describe how patients affected by these conditions may present to general practice, and discuss the reasons why they may not present. We also discuss how GPs can overcome difficulties in identifying and dealing with their male patients suffering from male reproductive system issues.

  15. IMPROVEMENT OF NON SPECIFIC IMMUNE SYSTEM ON COMMON CARP (Cyprinus carpio AGAINST KOI HERPESVIRUS DISEASE (KHVD BY ADDITION OF ASCORBIC ACID ON FISH DIET: A FIELD SCALE STUDY

    Directory of Open Access Journals (Sweden)

    Taukhid Taukhid

    2010-06-01

    Full Text Available The research with the aim to know the optimal feeding frequency of supplemented ascorbic acid (microencapsulated vitamin C CFC-90 on the dose of 750 mg/kg feed to control Koi Herpesvirus (KHV disease infecting common carp has been done in field condition. Fish were reared in floating cages with the size of 3.5 m x 3.5 m x 2.0 m and stocking density of 1,250 fish/cage with the size range of ± 10 g/fish. The treatments applied in the research were: (A daily application, (B every 3 days application, and (C without vitamin C addition as the control. Fish test were challenged to KHV infection on the mid cultivation by cohabitation method in the laboratory scale for 2 weeks. Examination on behavior, clinical sign, and mortality of fish test conducted daily. The results showed that the highest survival rate was found on the application of vitamin C every 3 days (60.16%; and followed by every day (52.00%, and the lowest was found on the control group (47.36%.

  16. New players in the same old game: a system level in silico study to predict type III secretion system and effector proteins in bacterial genomes reveals common themes in T3SS mediated pathogenesis.

    Science.gov (United States)

    Sadarangani, Vineet; Datta, Sunando; Arunachalam, Manonmani

    2013-07-26

    Type III secretion system (T3SS) plays an important role in virulence or symbiosis of many pathogenic or symbiotic bacteria [CHM 2:291-294, 2007; Physiology (Bethesda) 20:326-339, 2005]. T3SS acts like a tunnel between a bacterium and its host through which the bacterium injects 'effector' proteins into the latter [Nature 444:567-573, 2006; COSB 18:258-266, 2008]. The effectors spatially and temporally modify the host signalling pathways [FEMS Microbiol Rev 35:1100-1125, 2011; Cell Host Microbe5:571-579, 2009]. In spite its crucial role in host-pathogen interaction, the study of T3SS and the associated effectors has been limited to a few bacteria [Cell Microbiol 13:1858-1869, 2011; Nat Rev Microbiol 6:11-16, 2008; Mol Microbiol 80:1420-1438, 2011]. Before one set out to perform systematic experimental studies on an unknown set of bacteria it would be beneficial to identify the potential candidates by developing an in silico screening algorithm. A system level study would also be advantageous over traditional laboratory methods to extract an overriding theme for host-pathogen interaction, if any, from the vast resources of data generated by sequencing multiple bacterial genomes. We have developed an in silico protocol in which the most conserved set of T3SS proteins was used as the query against the entire bacterial database with increasingly stringent search parameters. It enabled us to identify several uncharacterized T3SS positive bacteria. We adopted a similar strategy to predict the presence of the already known effectors in the newly identified T3SS positive bacteria. The huge resources of biochemical data [FEMS Microbiol Rev 35:1100-1125, 2011; Cell Host Microbe 5:571-579, 2009; BMC Bioinformatics 7(11):S4, 2010] on the T3SS effectors enabled us to search for the common theme in T3SS mediated pathogenesis. We identified few cellular signalling networks in the host, which are manipulated by most of the T3SS containing pathogens. We went on to look for

  17. Performance of the engineering analysis and data system 2 common file system

    Science.gov (United States)

    Debrunner, Linda S.

    1993-01-01

    The Engineering Analysis and Data System (EADS) was used from April 1986 to July 1993 to support large scale scientific and engineering computation (e.g. computational fluid dynamics) at Marshall Space Flight Center. The need for an updated system resulted in a RFP in June 1991, after which a contract was awarded to Cray Grumman. EADS II was installed in February 1993, and by July 1993 most users were migrated. EADS II is a network of heterogeneous computer systems supporting scientific and engineering applications. The Common File System (CFS) is a key component of this system. The CFS provides a seamless, integrated environment to the users of EADS II including both disk and tape storage. UniTree software is used to implement this hierarchical storage management system. The performance of the CFS suffered during the early months of the production system. Several of the performance problems were traced to software bugs which have been corrected. Other problems were associated with hardware. However, the use of NFS in UniTree UCFM software limits the performance of the system. The performance issues related to the CFS have led to a need to develop a greater understanding of the CFS organization. This paper will first describe the EADS II with emphasis on the CFS. Then, a discussion of mass storage systems will be presented, and methods of measuring the performance of the Common File System will be outlined. Finally, areas for further study will be identified and conclusions will be drawn.

  18. Commonalities and differences between MDSplus and HDF5 data systems

    Energy Technology Data Exchange (ETDEWEB)

    Manduchi, G., E-mail: gabriele.manduchi@igi.cnr.i [Consorzio RFX, Euratom-ENEA Association, Corso Stati Uniti 4, Padova 35127 (Italy)

    2010-07-15

    MDSplus is a data acquisition system widely used in nuclear fusion experiments. It defines a file format for pulse files and provides a set of tools for data acquisition and management. The whole MDSplus package is used in several fusion experiments to set up and supervise the data acquisition process. Other experiments use only the data management layer of MDSplus to provide a common format for data exchange between plasma fusion laboratories. HDF5 is a file format and a data access library used by a larger community, mainly outside fusion. HDF5 is used, for example, in earth science research, defence applications and weather services. HDF5 allows managing large and complex data sets and provides a common data format among heterogeneous applications. Both MDSplus and HDF5 support a rich set of data types and a hierarchical data organization, as well as multi-language data access libraries. There are however several significant differences between the two system architectures, making each system better suited in different application contexts. The paper provides a brief overview of the data architectures of MDSplus and HDF5 and analyzes in detail the peculiar aspects of the two systems.

  19. Commonalities and differences between MDSplus and HDF5 data systems

    International Nuclear Information System (INIS)

    Manduchi, G.

    2010-01-01

    MDSplus is a data acquisition system widely used in nuclear fusion experiments. It defines a file format for pulse files and provides a set of tools for data acquisition and management. The whole MDSplus package is used in several fusion experiments to set up and supervise the data acquisition process. Other experiments use only the data management layer of MDSplus to provide a common format for data exchange between plasma fusion laboratories. HDF5 is a file format and a data access library used by a larger community, mainly outside fusion. HDF5 is used, for example, in earth science research, defence applications and weather services. HDF5 allows managing large and complex data sets and provides a common data format among heterogeneous applications. Both MDSplus and HDF5 support a rich set of data types and a hierarchical data organization, as well as multi-language data access libraries. There are however several significant differences between the two system architectures, making each system better suited in different application contexts. The paper provides a brief overview of the data architectures of MDSplus and HDF5 and analyzes in detail the peculiar aspects of the two systems.

  20. Effects of Common Cause Failure on Electrical Systems

    International Nuclear Information System (INIS)

    Pepper, Kevin

    2015-01-01

    The essential electrical systems of reactor designs have developed progressively with an increased focus on the use of redundant, segregated and independent safety system equipment 'trains'. In this arrangement, essential safety functions associated with safe shutdown and cooling of the reactor are replicated on near identical electrical systems with each of the trains of safety system equipment supported by a fully rated standby generator. Development in designs has seen the number of trains increased to enable maintenance to be undertaken with reactors at power, improving the economics of the units whilst maintaining nuclear safety. This paper provides a background to common cause failure and provides examples where supporting guidance and international experience is available. It also highlights the regulatory guidance available to UK licensees. Recent examples of common cause failures on plant in the UK are presented together with an issue identified during the recent Generic Design Assessment review of new reactor designs within the UK. It was identified that one design was claiming a very low probability of failure associated with the loss of a single break and no-break voltage level, orders of magnitude below the target figure within ONR's Safety Assessment Principles. On closer scrutiny it was established that a significant safety function provided from identical low voltage switchboards would be lost in the event of a common cause failure affecting these boards. The paper will explain the action that has been taken by the requesting party to improve the resilience of the design and how this impacts on the ONR reliability targets for reactor designs within the UK. (authors)

  1. ATLAS magnet common cryogenic, vacuum, electrical and control systems

    CERN Document Server

    Miele, P; Delruelle, N; Geich-Gimbel, C; Haug, F; Olesen, G; Pengo, R; Sbrissa, E; Tyrvainen, H; ten Kate, H H J

    2004-01-01

    The superconducting Magnet System for the ATLAS detector at the LHC at CERN comprises a Barrel Toroid, two End Cap Toroids and a Central Solenoid with overall dimensions of 20 m diameter by 26 m length and a stored energy of 1.6 GJ. Common proximity cryogenic and electrical systems for the toroids are implemented. The Cryogenic System provides the cooling power for the 3 toroid magnets considered as a single cold mass (600 tons) and for the CS. The 21 kA toroid and the 8 kA solenoid electrical circuits comprise both a switch-mode power supply, two circuit breakers, water cooled bus bars, He cooled current leads and the diode resistor ramp-down unit. The Vacuum System consists of a group of primary rotary pumps and sets of high vacuum diffusion pumps connected to each individual cryostat. The Magnet Safety System guarantees the magnet protection and human safety through slow and fast dump treatment. The Magnet Control System ensures control, regulation and monitoring of the operation of the magnets. The update...

  2. Parallel discrete ordinates algorithms on distributed and common memory systems

    International Nuclear Information System (INIS)

    Wienke, B.R.; Hiromoto, R.E.; Brickner, R.G.

    1987-01-01

    The S/sub n/ algorithm employs iterative techniques in solving the linear Boltzmann equation. These methods, both ordered and chaotic, were compared on both the Denelcor HEP and the Intel hypercube. Strategies are linked to the organization and accessibility of memory (common memory versus distributed memory architectures), with common concern for acquisition of global information. Apart from this, the inherent parallelism of the algorithm maps directly onto the two architectures. Results comparing execution times, speedup, and efficiency are based on a representative 16-group (full upscatter and downscatter) sample problem. Calculations were performed on both the Los Alamos National Laboratory (LANL) Denelcor HEP and the LANL Intel hypercube. The Denelcor HEP is a 64-bit multi-instruction, multidate MIMD machine consisting of up to 16 process execution modules (PEMs), each capable of executing 64 processes concurrently. Each PEM can cooperate on a job, or run several unrelated jobs, and share a common global memory through a crossbar switch. The Intel hypercube, on the other hand, is a distributed memory system composed of 128 processing elements, each with its own local memory. Processing elements are connected in a nearest-neighbor hypercube configuration and sharing of data among processors requires execution of explicit message-passing constructs

  3. Delphi's new direct acting common rail injection system; Das neue Direct Acting Common Rail System von Delphi

    Energy Technology Data Exchange (ETDEWEB)

    Schoeppe, Detlev; Zuelch, Stefan; Geurts, Derk; Gris, Christian; Jorach, Rainer W. [Delphi Diesel Systems, Europe (United Kingdom)

    2009-07-01

    With the serial start of the Direct Acting Common Rail injection system with 2.000 bar Delphi Diesel Systems could supplement its product portfolio with a valuable component. In Delphi's directly propelled Common Rail injector, the Injection needle directly is set in operation with the help of a piezo-ceramic actuator instead of only controlling this with a conventional servo-hydraulic circuit indirectly. This enables a fast opening and closing of the nozzle needle possible independently from the rail pressure. The process of injection is controllable accurately at any time with the again developed two-stage needle movement amplifier. The additionally in the injector integrated fuel storage works as a 'Rail in the Injector' and improves the quality particularly during multiple injection. The injector completely works leakage-free and thereby helps to reach the future CO{sub 2} targets. The use of piezo-actuators as driving force behind the directly working injector leads to a set of requirements to the electronics. A control electronics was developed in order to head optimally the Direct Acting Injector. The sum of all advantages of the Direct Acting of CR systems enables lowest emissions with simultaneously small fuel consumption while new dimensions are reached with power density and engine torque. The authors of the contribution under consideration report on the construction, on the work principle of the Direct Acting CR system and on its performance characteristics as a basis for the premium diesel engine.

  4. Common Rail System for GDI Engines Modelling, Identification, and Control

    CERN Document Server

    Fiengo, Giovanni; Palladino, Angelo; Giglio, Veniero

    2013-01-01

    Progressive reductions in vehicle emission requirements have forced the automotive industry to invest in research and development of alternative control strategies. Continual control action exerted by a dedicated electronic control unit ensures that best performance in terms of pollutant emissions and power density is married with driveability and diagnostics. Gasoline direct injection (GDI) engine technology is a way to attain these goals. This brief describes the functioning of a GDI engine equipped with a common rail (CR) system, and the devices necessary to run test-bench experiments in detail. The text should prove instructive to researchers in engine control and students are recommended to this brief as their first approach to this technology. Later chapters of the brief relate an innovative strategy designed to assist with the engine management system; injection pressure regulation for fuel pressure stabilization in the CR fuel line is proposed and validated by experiment. The resulting control scheme ...

  5. Pressure Fluctuations in a Common-Rail Fuel Injection System

    Science.gov (United States)

    Rothrock, A M

    1931-01-01

    This report presents the results of an investigation to determine experimentally the instantaneous pressures at the discharge orifice of a common-rail fuel injection system in which the timing valve and cut-off valve were at some distance from the automatic fuel injection valve, and also to determine the methods by which the pressure fluctuations could be controlled. The results show that pressure wave phenomena occur between the high-pressure reservoir and the discharge orifice, but that these pressure waves can be controlled so as to be advantageous to the injection of the fuel. The results also give data applicable to the design of such an injection system for a high-speed compression-ignition engine.

  6. Formation of common cultural competence in country studies ...

    African Journals Online (AJOL)

    ... in country studies classes (based on Turkish language teaching practice) ... the acquisition of common cultural competence in foreign language education. ... analysis of methodological frameworks offered by Russian and foreign specialists.

  7. Biomechanical studies: science (f)or common sense?

    NARCIS (Netherlands)

    Mellema, Jos J.; Doornberg, Job N.; Guitton, Thierry G.; Ring, David; van der Zwan, A. L.; Spoor, A. B.; van Vugt, A. B.; Armstrong, A. D.; Shrivastava, A.; Wahegaonkar, A. L.; Shafritz, A. B.; Adams, J.; Ilyas, A.; Vochteloo, A. J. H.; Castillo, A. P.; Basak, A.; Andreas, P.; Barquet, A.; Kristan, A.; Berner, A.; Ranade, A. B.; Ashish, S.; Terrono, A. L.; Jubel, A.; Frieman, B.; Bamberger, H. B.; van den Bekerom, M. P. J.; Belangero, W. D.; Hearon, B. F.; Boler, J. M.; Walter, F. L.; Boyer, M.; Wills, B. P. D.; Broekhuyse, H.; Buckley, R.; Watkins, B.; Sears, B. W.; Calfee, R. P.; Ekholm, C.; Fernandes, C. H.; Swigart, C.; Cassidy, C.; Wilson, C. J.; Bainbridge, L. C.; Wilson, C.; Eygendaal, D.; Goslings, J. C.; Schep, N.; Kloen, P.; Haverlag, R.

    2014-01-01

    It is our impression that many biomechanical studies invest substantial resources studying the obvious: that more and larger metal is stronger. The purpose of this study is to evaluate if a subset of biomechanical studies comparing fixation constructs just document common sense. Using a web-based

  8. Mars Surface System Common Capabilities and Challenges for Human Missions

    Science.gov (United States)

    Hoffman, Stephen J.; Toups, Larry

    2016-01-01

    exploring the scientific ROIs within the boundaries of the EZ. The proposed paper will describe the current status of common systems and operations as they can be applied to actual EZ locations on Mars. Initially these EZs will be the four locations identified MEPAG's Human Exploration of Mars Science Analysis Group (HEM-SAG) that will be used as representative of the EZs that will emerge from the process that NASA has initiated. An example process that could be commonly applied is an approach for developing a field station site plan that would be demonstrated by applying this process to each of the four HEM-SAG sites. Examples of common systems include (a) mobility systems that can be used to off-load and move payloads to specific locations at the central field station location that could also be used to traverse long distances to reach some of the more remote ROIs or (b) robotic systems that can support various activities (such as system set up and maintenance) at the field station that could also be used to explore scientific ROIs and used to support site-specific ISRU production activities.

  9. System diagnosis using finite memory observers: Common Rail application; Diagnostic des systemes a l'aide d'observateurs a memoire finie: application au Common Rail

    Energy Technology Data Exchange (ETDEWEB)

    Graton, G.

    2005-12-15

    The aim of this work was to propose a fault detection method on the high pressure direct injection system (called Common Rail system) set up on Diesel vehicles. The importance of the fault detection procedure implementation was highlighted thanks to the description of the stakes (lowers consumption, reduction in the pollutant emissions and sound, increase of performances) and constraints dependent on Common Rail (high pressure, high frequency, gas oil lubrication, high precision machining, standards EURO respect,...) but also through a listing of failures which can occur on Common Rail. A synthesis on the different diagnosis methods of systems contributed to select a fault detection method with expected performances (detection of fault beginning, detection speed, isolation and characterization of detected fault and minimizing false alarm and bad detections). After a detailed study (properties, sequential formulations and sensitivity study) of the selected detection method (finite memory observers) and a modeling of the Common Rail various bodies behavior, the algorithm of detection was tested on three different models of the system Common Rail. Moreover, the comparison between the finite memory observer and a Luenberger observer and a Kalman filter allow to appreciate the residual robustness degree. Obtained results allow to conclude on good detection of actuator and sensor faults. (author)

  10. Harmonics Study of Common Low Wattage LED Lamps

    Directory of Open Access Journals (Sweden)

    Ioan Dragoş Deaconu

    2017-11-01

    Full Text Available This article presents experimental data on Light Emitting Diode (LED lamps of low wattage that are commonly found both in commercial and residential applications. A comparison with the existing regulations is performed. The measurements are performed using power and energy quality analyzer intended also for avionic and military systems.

  11. Mars Surface Systems Common Capabilities and Challenges for Human Missions

    Science.gov (United States)

    Toups, Larry; Hoffman, Stephen J.

    2016-01-01

    This paper describes the current status of common systems and operations as they are applied to actual locations on Mars that are representative of Exploration Zones (EZ) - NASA's term for candidate locations where humans could land, live and work on the Martian surface. Given NASA's current concepts for human missions to Mars, an EZ is a collection of Regions of Interest (ROIs) located within approximately 100 kilometers of a centralized landing site. ROIs are areas that are relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. An EZ also contains a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. The Evolvable Mars Campaign (EMC), a description of NASA's current approach to these human Mars missions, assumes that a single EZ will be identified within which NASA will establish a substantial and durable surface infrastructure that will be used by multiple human crews. The process of identifying and eventually selecting this single EZ will likely take many years to finalized. Because of this extended EZ selection process it becomes important to evaluate the current suite of surface systems and operations being evaluated for the EMC as they are likely to perform at a variety of proposed EZ locations and for the types of operations - both scientific and development - that are proposed for these candidate EZs. It is also important to evaluate proposed EZs for their suitability to be explored or developed given the range of capabilities and constraints for the types of surface systems and operations being considered within the EMC. Four locations identified in the Mars Exploration Program Analysis Group (MEPAG)'s Human Exploration of Mars Science Analysis Group (HEM-SAG) report are used in this paper as representative of candidate EZs that will emerge from the selection process that NASA has initiated. A field

  12. DSF: A Common Platform for Distributed Systems Research and Development

    Science.gov (United States)

    Tang, Chunqiang

    This paper presents Distributed Systems Foundation (DSF), a common platform for distributed systems research and development. It can run a distributed algorithm written in Java under multiple execution modes—simulation, massive multi-tenancy, and real deployment. DSF provides a set of novel features to facilitate testing and debugging, including chaotic timing test and time travel debugging with mutable replay. Unlike existing research prototypes that offer advanced debugging features by hacking programming tools, DSF is written entirely in Java, without modifications to any external tools such as JVM, Java runtime library, compiler, linker, system library, OS, or hypervisor. This simplicity stems from our goal of making DSF not only a research prototype but more importantly a production tool. Experiments show that DSF is efficient and easy to use. DSF's massive multi-tenancy mode can run 4,000 OS-level threads in a single JVM to concurrently execute (as opposed to simulate) 1,000 DHT nodes in real-time.

  13. Common cause failure and systems interactions issues - an overview

    International Nuclear Information System (INIS)

    Worledge, D.H.; Chu, B.B.; Conradi, L.L.; Smith, A.M.

    1985-01-01

    Common cause failures (CCFs) and systems interactions (SIs) are two concerns which have received significant attention over the years. Although many large and varied efforts have been directed toward these concerns, their resolution is less than satisfactory. Problems continue to exist, both in terms of understanding the basic issues represented by these concerns, and the perceived need for protection against their potentially harmful effects. This paper presents the results of recent EPRI work to provide a basis of understanding of these issues. Based on that improved understanding, a more appropriate way of defining and approaching the underlying technical questions is suggested. The current means of addressing the CCF and SI concerns are discussed and areas of additional activity needed to allow a more effective resolution are identified

  14. Paradigms of artificial intelligence programming case studies in common Lisp

    CERN Document Server

    Norvig, Peter

    1991-01-01

    Paradigms of AI Programming is the first text to teach advanced Common Lisp techniques in the context of building major AI systems. By reconstructing authentic, complex AI programs using state-of-the-art Common Lisp, the book teaches students and professionals how to build and debug robust practical programs, while demonstrating superior programming style and important AI concepts. The author strongly emphasizes the practical performance issues involved in writing real working programs of significant size. Chapters on troubleshooting and efficiency are included, along with a discussion of th

  15. Study of Power Quality at the Point of Common Coupling of a Low Voltage Grid and a Distributed Generation System of 7.8 kWp in a Tropical Region

    Directory of Open Access Journals (Sweden)

    Agustín Valverde Granja

    2018-06-01

    Full Text Available In this paper we analyze an experimental 1000 kWh/month distributed generation system in a tropical region connected to a point of common coupling in a low voltage grid that was characterized according to NTC 5001. This photovoltaic system has 7.8 kWp and uses 30 polycrystalline silicon-panels of 260 Wp each. Its maximum energy produced was 850 kWh/month, equivalent to 72.65% of the installed capacity. Finally, there was an increase of 2% with respect to the minimum voltage value that was recorded. The voltage unbalance decreases between 3.5 and 70% and voltage harmonics in each line increased by 7% on line U1, 0.8% on U2, 3% on U3 and current harmonics have a 22% increase. Likewise, the total active and reactive power were increased by 58% and 42% respectively, and the thermography study allowed to establish a temperature increase at the point of common coupling of 7.5%. Therefore, it is expected that this paper can serve as a reference for the application of Colombian law 1715 in solar energy.

  16. Implications of Common Core State Standards on the Social Studies

    Science.gov (United States)

    Kenna, Joshua L.; Russell, William B., III.

    2014-01-01

    Social studies teachers have often been on the outside looking in during much of the era billed as the standards-based educational reform (SBER), but with the adoption and implementation of the Common Core State Standards (CCSS), social studies teachers seem to have been invited back inside. Yet, how will the standards impact social studies…

  17. Human adaptive behavior in common pool resource systems.

    Directory of Open Access Journals (Sweden)

    Gunnar Brandt

    Full Text Available Overexploitation of common-pool resources, resulting from uncooperative harvest behavior, is a major problem in many social-ecological systems. Feedbacks between user behavior and resource productivity induce non-linear dynamics in the harvest and the resource stock that complicate the understanding and the prediction of the co-evolutionary system. With an adaptive model constrained by data from a behavioral economic experiment, we show that users' expectations of future pay-offs vary as a result of the previous harvest experience, the time-horizon, and the ability to communicate. In our model, harvest behavior is a trait that adjusts to continuously changing potential returns according to a trade-off between the users' current harvest and the discounted future productivity of the resource. Given a maximum discount factor, which quantifies the users' perception of future pay-offs, the temporal dynamics of harvest behavior and ecological resource can be predicted. Our results reveal a non-linear relation between the previous harvest and current discount rates, which is most sensitive around a reference harvest level. While higher than expected returns resulting from cooperative harvesting in the past increase the importance of future resource productivity and foster sustainability, harvests below the reference level lead to a downward spiral of increasing overexploitation and disappointing returns.

  18. MDEP Generic Common Position No DICWG-01. Common position on the treatment of common cause failure caused by software within digital safety systems

    International Nuclear Information System (INIS)

    2013-01-01

    Common cause failures (CCF)2 have been a significant safety concern for nuclear power plant systems. The increasing dependence on software-in safety systems for nuclear power plants has increased the safety significance of CCF caused by software, when software in redundant channels or portions of safety systems has some common dependency. For example, the effect of systematic failures can lead to a loss of safety in many ways: unwanted actuations, a safety function is not provided when needed. Therefore, nuclear power plants should be systematically protected from the effects of common cause failures caused by software in DI and C safety systems. Software for nuclear power plant safety systems should be of the high quality necessary to help assure against the loss of safety (i.e. developed with high-quality engineering practices, commensurate quality assurance applied, with continuous improvement through corrective actions based on lessons learned from operating experience). However, demonstrating adequate software quality only through verification and validation activities and controls on the development process has proved to be problematic. Therefore, this common position provides guidance for the assessment of the potential for CCF for software. It is recognized that programmable logic devices do not execute software in the conventional sense; however, the application development process using these devices have many similarities with software development, and the deficiencies that may be introduced during the application development process may induce errors in the programmable logic devices that can result in common cause failures of these devices of a type similar to software common cause failure. Although deficiencies with the potential to give rise to software common cause failures can be introduced at all phases of the software life cycle, this common position will only consider the potential for software common cause failures within digital safety system

  19. Servo-driven piezo common rail diesel injection system; Servogetriebene Piezo-Common-Rail-Dieseleinspritzung

    Energy Technology Data Exchange (ETDEWEB)

    Schoeppe, Detlev; Stahl, Christian; Krueger, Grit; Dian, Vincent [Continental Automotive GmbH, Regensburg (Germany). Geschaeftsbereich Engine Systems

    2012-03-15

    The requirements to be met by future diesel engines represent major challenges for fuel injection technology: Fuel consumption, emissions and noise development are to be further reduced without impairing driving enjoyment. To address these challenges, Continental has developed a new fuel injection system that features a high level of precision and accuracy. The key component is a servo-driven injector that is operated in a closed control circuit. (orig.)

  20. Computer aided approach to qualitative and quantitative common cause failure analysis for complex systems

    International Nuclear Information System (INIS)

    Cate, C.L.; Wagner, D.P.; Fussell, J.B.

    1977-01-01

    Common cause failure analysis, also called common mode failure analysis, is an integral part of a complete system reliability analysis. Existing methods of computer aided common cause failure analysis are extended by allowing analysis of the complex systems often encountered in practice. The methods aid in identifying potential common cause failures and also address quantitative common cause failure analysis

  1. Common-mode Voltage Reduction in a Motor Drive System with a Power Factor Correction

    DEFF Research Database (Denmark)

    Adabi, J.; Boora, A.A.; Zare, F.

    2012-01-01

    Common-mode voltage generated by a power converter in combination with parasitic capacitive couplings is a potential source of shaft voltage in an AC motor drive system. In this study, a three-phase motor drive system supplied with a single-phase AC-DC diode rectifier is investigated in order...... to reduce shaft voltage in a three-phase AC motor drive system. In this topology, the AC-DC diode rectifier influences the common-mode voltage generated by the inverter because the placement of the neutral point is changing in different rectifier circuit states. A pulse width modulation technique...

  2. Treatment of trace organic compounds in common onsite wastewater systems

    Science.gov (United States)

    Robert Siegrist,; Conn, Kathleen E.

    2015-01-01

    Onsite wastewater systems (OWS) have historically been relied on to treat conventional pollutants and pathogens in a fashion similar to that expected from centralized wastewater systems. However, based on the occurrence of, and potential effects from, contaminants of emerging concern in wastewaters, OWS as well as centralized systems need to account for these compounds in system design and use. One group of contaminants involves organic compounds such as those associated with consumer product chemicals and pharmaceuticals, which are collectively referred to as trace organic compounds (TOrCs) due to their very low levels (e.g., ng/L to ug/L) relative to other pollutants. The question being confronted today is how best to account for TOrCs in onsite system design and use while also achieving other goals such as system simplicity, limited operation and maintenance requirements, low cost, and sustainability. In contrast to conventional pollutants such as nutrients and pathogens which have specific and achievable treatment goals, there are currently no enforceable treatment standards for TOrCs, which often have non-traditional toxicological endpoints (i.e. endocrine disruption). As highlighted in this paper, there are a large number of TOrCs that can be present in OWS and they have different properties, can be present at different frequencies of occurrence and concentrations, and have different susceptibilities to treatment in OWS. In general, based on the studies summarized in this paper, TOrCs normally should not require additional considerations beyond those for conventional pollutants and pathogens (e.g., nitrogen or bacteria and virus) during design and use of OWS. That said, there are situations where TOrCs could be a serious concern warranting special consideration in system design and use. In this paper, the frequency of occurrence of TOrCs and the range of concentrations encountered are highlighted. An evolving approach is outlined that could help assess the

  3. Ecotoxicological study of insecticide effects on arthropods in common bean.

    Science.gov (United States)

    de Barros, Emerson Cristi; Ventura, Hudson Vaner; Gontijo, Pablo Costa; Pereira, Renata Ramos; Picanço, Marcelo Coutinho

    2015-01-01

    Arthropods are an important group of macroorganisms that work to maintain ecosystem health. Despite the agricultural benefits of chemical control against arthropod pests, insecticides can cause environmental damage. We examined the effects of one and two applications of the insecticides chlorfenapyr (0.18 liters a.i. ha-1) and methamidophos (0.45 liters a.i. ha-1), both independently and in combination, on arthropods in plots of common bean. The experiment was repeated for two growing seasons. Principal response curve, richness estimator, and Shannon-Wiener diversity index analyses were performed. The insecticides generally affected the frequency, richness, diversity, and relative abundance of the arthropods. In addition, the arthropods did not experience recovery after the insecticide applications. The results suggest that the insecticide impacts were sufficiently drastic to eliminate many taxa from the studied common bean plots. © The Author 2015. Published by Oxford University Press on behalf of the Entomological Society of America.

  4. PLS and multicollinearity under conditions common in satisfaction studies

    DEFF Research Database (Denmark)

    Nielsen, Rikke; Kristensen, Kai; Eskildsen, Jacob Kjær

    A number of studies have investigated the performance of the PLS path modelling algorithm in the presence of common empirical problems, such as model misspecification, skewness of manifest variables, missing values, and multicollinearity, and they have shown PLS to be quite robust (see e.g. Cassel...... et al., 1999; Kristensen, Eskildsen, 2005). However, most of the studies, including our own, have focused on somewhat simple models with very simple correlation structures. This paper extends the existing knowledge by investigating the effect of varying degrees of multicollinearity on the PLS model...

  5. THE STATE OF THE COMMONS: CASE STUDIES 2010

    Directory of Open Access Journals (Sweden)

    Rachel Cobcroft

    2010-01-01

    Full Text Available Abstract: ‘What artists need to see before they can feel confident about the licenses are examples of other[s] taking the licenses; incorporating them into their practices.’ – OpenBusiness.cc, p. 8 The Creative Commons Case Studies initiative, established in 2008, offers the ‘free culture’community a qualitative resource to chronicle trends in open content licensing (OCL. Seeking feedback as to individual and organisational motivations towards OCL adoption, and through its provision of usage data, jurisdiction and disciplinary distribution, the CC Case Studies wiki complements current quantitative research projects such as CC Monitor. Containing over 200 entries in July 2010, the CC Case Studies wiki covers several genres such as publishing, moving images, music, visual arts, interactive resources including games, performance, education, and ‘government 2.0’ open data initiatives. Entries represent 25 contributing jurisdictions, with studies being written in several languages including English, Spanish, Portuguese, German, and Korean. By sharing stories of success and identifying areas of innovation and collaboration, the CC Case Studies wiki encourages creators to contribute to the Commons, whilst contributing to a broader understanding of the dynamics of ‘free culture.’

  6. Phase Noise Effect on MIMO-OFDM Systems with Common and Independent Oscillators

    DEFF Research Database (Denmark)

    Chen, Xiaoming; Wang, Hua; Fan, Wei

    2018-01-01

    In this paper, the effects of oscillator phase noises (PNs) on multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) systems are studied. It is shown that PNs of common oscillators at the transmitter and at the receiver have the same influence on the performance ...

  7. Phase Noise Effect on MIMO-OFDM Systems with Common and Independent Oscillators

    Directory of Open Access Journals (Sweden)

    Xiaoming Chen

    2017-01-01

    Full Text Available The effects of oscillator phase noises (PNs on multiple-input multiple-output (MIMO orthogonal frequency division multiplexing (OFDM systems are studied. It is shown that PNs of common oscillators at the transmitter and at the receiver have the same influence on the performance of (single-stream beamforming MIMO-OFDM systems, yet different influences on spatial multiplexing MIMO-OFDM systems with singular value decomposition (SVD based precoding/decoding. When each antenna is equipped with an independent oscillator, the PNs at the transmitter and at the receiver have different influences on beamforming MIMO-OFDM systems as well as spatial multiplexing MIMO-OFDM systems. Specifically, the PN effect on the transmitter (receiver can be alleviated by having more transmit (receive antennas for the case of independent oscillators. It is found that the independent oscillator case outperforms the common oscillator case in terms of error vector magnitude (EVM.

  8. Spawning Induction System of Puntius javanicus using Common Carp as a Trigger

    Directory of Open Access Journals (Sweden)

    M. Zairin Junior

    2007-07-01

    Full Text Available This study was carried out to determine the effect of induction using common carp as a trigger on spawning of Puntius javanicus.  Mature male and female of Puntius javanicus were reared in outer of the hapa that contains mature male common carp, mature female common carp, or mature male and female common carp as a control.  Common carp broodstock was injected or not injected by ovaprim.  The result of study show that the use of male common carp injected or not injected by ovaprim could induced spawning of Puntius javanicus, without the release of sperm and eggs of common carp.   Fertilization rate of Puntius javanicus eggs was high, reached of 91.4%, by using ovaprim-injected male common carp as trigger. Keywords: Puntius javanicus, common carp, Cyprinus carpio, spawning, induction system   ABSTRAK Penelitian ini dilakukan untuk mengetahui pengaruh sistem imbas menggunakan ikan mas (Cyprinus carpio sebagai pemicu terhadap pemijahan ikan tawes (Puntius javanicus. Induk ikan tawes jantan dan betina yang telah matang gonad ditempatkan di luar hapa tempat ikan mas jantan matang gonad, ikan mas betina matang gonad, atau sepasang ikan mas matang gonad sebagai perlakuan kontrol. Induk ikan mas disuntik atau tidak dengan ovaprim.  Hasil penelitian menunjukkan bahwa penggunaan ikan mas yang disuntik ovaprim maupun tidak, dapat mengimbas ikan tawes untuk memijah meskipun tidak terjadi pengeluaran sperma dan telur ikan mas. Derajat pembuahan telur ikan tawes cukup tinggi, mencapai 91,4%, pada perlakuan induksi ikan mas jantan yang disuntik ovaprim. Kata kunci: Puntius javanicus, common carp, Cyprinus carpio, pemijahan, sistem imbas

  9. Neuroimaging Studies Illustrate the Commonalities Between Ageing and Brain Diseases.

    Science.gov (United States)

    Cole, James H

    2018-07-01

    The lack of specificity in neuroimaging studies of neurological and psychiatric diseases suggests that these different diseases have more in common than is generally considered. Potentially, features that are secondary effects of different pathological processes may share common neurobiological underpinnings. Intriguingly, many of these mechanisms are also observed in studies of normal (i.e., non-pathological) brain ageing. Different brain diseases may be causing premature or accelerated ageing to the brain, an idea that is supported by a line of "brain ageing" research that combines neuroimaging data with machine learning analysis. In reviewing this field, I conclude that such observations could have important implications, suggesting that we should shift experimental paradigm: away from characterizing the average case-control brain differences resulting from a disease toward methods that place individuals in their age-appropriate context. This will also lead naturally to clinical applications, whereby neuroimaging can contribute to a personalized-medicine approach to improve brain health. © 2018 WILEY Periodicals, Inc.

  10. Common accounting system for monitoring the ATLAS distributed computing resources

    International Nuclear Information System (INIS)

    Karavakis, E; Andreeva, J; Campana, S; Saiz, P; Gayazov, S; Jezequel, S; Sargsyan, L; Schovancova, J; Ueda, I

    2014-01-01

    This paper covers in detail a variety of accounting tools used to monitor the utilisation of the available computational and storage resources within the ATLAS Distributed Computing during the first three years of Large Hadron Collider data taking. The Experiment Dashboard provides a set of common accounting tools that combine monitoring information originating from many different information sources; either generic or ATLAS specific. This set of tools provides quality and scalable solutions that are flexible enough to support the constantly evolving requirements of the ATLAS user community.

  11. Comparison of Three Commercial Systems for Identification of Yeasts Commonly Isolated in the Clinical Microbiology Laboratory

    Science.gov (United States)

    Wadlin, Jill K.; Hanko, Gayle; Stewart, Rebecca; Pape, John; Nachamkin, Irving

    1999-01-01

    We evaluated three commercial systems (RapID Yeast Plus System; Innovative Diagnostic Systems, Norcross, Ga.; API 20C Aux; bioMerieux-Vitek, Hazelwood, Mo.; and Vitek Yeast Biochemical Card, bioMerieux-Vitek) against an auxinographic and microscopic morphologic reference method for the ability to identify yeasts commonly isolated in our clinical microbiology laboratory. Two-hundred one yeast isolates were compared in the study. The RapID Yeast Plus System was significantly better than either API 20C Aux (193 versus 167 correct identifications; P clinically relevant yeasts. PMID:10325356

  12. The endogenous opioid system: a common substrate in drug addiction.

    Science.gov (United States)

    Trigo, José Manuel; Martin-García, Elena; Berrendero, Fernando; Robledo, Patricia; Maldonado, Rafael

    2010-05-01

    Drug addiction is a chronic brain disorder leading to complex adaptive changes within the brain reward circuits that involve several neurotransmitters. One of the neurochemical systems that plays a pivotal role in different aspects of addiction is the endogenous opioid system (EOS). Opioid receptors and endogenous opioid peptides are largely distributed in the mesolimbic system and modulate dopaminergic activity within these reward circuits. Chronic exposure to the different prototypical drugs of abuse, including opioids, alcohol, nicotine, psychostimulants and cannabinoids has been reported to produce significant alterations within the EOS, which seem to play an important role in the development of the addictive process. In this review, we will describe the adaptive changes produced by different drugs of abuse on the EOS, and the current knowledge about the contribution of each component of this neurobiological system to their addictive properties.

  13. Common fluoroscopic studies in radiology : conduct and analysis method

    International Nuclear Information System (INIS)

    Valverde Sanchez, Allan

    2011-01-01

    A countless number of radiological procedures, that have involved the use of fluoroscopy and contrast media of different indole, have been carried out in all radiology services and medical images of Costa Rica for the diagnosis of diseases or conditions, in both adults and in children. Fluoroscopic studies, often called special or contrast studies, have had particular conditions for its realization. Some from the medical point of view: adequate training in the technical and cognitive development when evaluating the images to not miss important details. Other by the patient: adequate preparation to achieve the best images for optimal diagnosis. For example, adequate bowel preparation is essential for a barium enema, to cooperation by the patient to meet specific indications that the physician dictates when swallowing postures or just when you are prompted. Criteria have been met and unified for contrast studies in different hospitals and clinics. The indications, contra, method, technique of procedure, points to remember, number of images or projections minimum required in the interpretation of contrast studies, as well as a report template of standard and ideal study are presented in a simple, systematic and logical. The manual is intended for residents and attending physicians specialists in radiology and medical imaging including contrast studies more common. Spaces are promoted with current technology studies to set aside more complicated and less sophisticated as have been the fluoroscopic studies; however, in the national reality, access to computerized tomography and magnetic resonance imaging is not as easy. Radiological studies with fluoroscopy performed by trained staff led the treating physician to make sound decisions based on studies relatively simple and easy to do. The tests with the use of fluoroscopic have been named: the esophagogram, gastroduodenal series, gastro intestinal transit, the hysterosalpingography, the cystography and the

  14. Quantification of the occurrence of common-mode faults in highly reliable protective systems

    International Nuclear Information System (INIS)

    Aitken, A.

    1978-10-01

    The report first covers the investigation, definition and classification of common mode failure (CMF) based on an extensive study of the nature of CMF. A new classification of CMF is proposed, based on possible causes of failures. This is used as a basis for analysing data from reported failures of reactor safety systems and aircraft systems. Design and maintenance errors are shown to be predominant cause of CMF. The estimated CMF rates for the highly reliable nuclear power plant automatic protection system (APS) and for the emergency core cooling system (ECCS) are 2.8.10 -2 CMF/sub-system-year and 3.3.10 -2 CMF/sub-system-year respectively. For comparison, the data from the aircraft accident records have shown a CMF rate for total flight control system (FCS), 2.1.10 -5 CMF/sub-system-year. The analysis has laid the grounds for work on relating CMF modelling and defences

  15. Comparisons of Bitcoin Cryptosystem with Other Common Internet Transaction Systems by AHP Technique

    Directory of Open Access Journals (Sweden)

    Davor Maček

    2017-01-01

    Full Text Available This paper describes proposed methodology for evaluation of critical systems and prioritization of critical risks and assets identified in highly secured information systems. For different types of information assets or security environments it is necessary to apply different techniques and methods for their prioritization and evaluation. In this article, VECTOR matrix method for prioritization of critical assets and critical risks is explained and integrated into AHP (Analytic Hierarchy Process technique as a set of fixed criteria for evaluation of defined alternatives. Bitcoin cryptocurrency was compared and evaluated along with other common Internet transaction systems by information security professionals according to defined VECTOR criteria. Also, the newly proposed hybrid AHP model is presented with potential case studies for future research. This article tries to discover security posture of Bitcoin cryptocurrency in the context of information security risks related to the existing most common online payment systems like e-banking, m-banking, and e-commerce.

  16. Virtual Communities as Commons: Case Study of “Connect”

    Directory of Open Access Journals (Sweden)

    Jasmina Božić

    2008-06-01

    Full Text Available In a world increasingly networked with the help of information technology, where face-to-face communities are more and more supported by computer-mediated communication, and some communities exist solely in virtual space, the perennial social dilemma of cooperation has resurged, intriguing social researchers’ attention with new elements brought about by technological advances, such as software applications enabling simultaneous communication of community members through public and private channels, easy access to a variety of documents, anonymous messaging, forums for potentially unlimited number of members who may join or observe, and a number of other IT-enabled community-building tools. In this paper the authors discuss the cooperation problem in virtual communities through the case-study of “Connect”, an online community of Croatian scientists. Starting point of the analysis is the observation that cooperation in virtual communities may be encouraged by implementing technological solutions that provide users with incentives to cooperate. With this in mind, the authors inspect the compliance of “Connect” to a set of design principles of robust common-pool resource institutions elaborated by Elinor Ostrom. The study demonstrates that the “Connect” satisfies the majority of Ostrom’s principles, with some room for improvement, and fails to satisfy two of them, mainly due to non-existence of technical prerequisites and due to relatively small size of the community. The analysis lays ground for further work aimed at obtaining more prescriptive guidelines that would point to possible improvements in management of common pool resources in virtual communities.

  17. Mistreatment of university students most common during medical studies

    Directory of Open Access Journals (Sweden)

    Nuutinen Matti

    2005-10-01

    Full Text Available Abstract Background This study concerns the occurrence of various forms of mistreatment by staff and fellow students experienced by students in the Faculty of Medicine and the other four faculties of the University of Oulu, Finland. Methods A questionnaire with 51 questions on various forms of physical and psychological mistreatment was distributed to 665 students (451 females after lectures or examinations and filled in and returned. The results were analysed by gender and faculty. The differences between the males and females were assessed statistically using a test for the equality of two proportions. An exact two-sided P value was calculated using a mid-P approach to Fisher's exact test (the null hypothesis being that there is no difference between the two proportions. Results About half of the students answering the questionnaire had experienced some form of mistreatment by staff during their university studies, most commonly humiliation and contempt (40%, negative or disparaging remarks (34%, yelling and shouting (23%, sexual harassment and other forms of gender-based mistreatment (17% and tasks assigned as punishment (13%. The students in the Faculty of Medicine reported every form of mistreatment more commonly than those in the Faculties of Humanities, Education, Science and Technology. Experiences of mistreatment varied, but clear messages regarding its patterns were to be found in each faculty. Female students reported more instances of mistreatment than males and were more disturbed by them. Professors, lecturers and other staff in particular mistreated female students more than they mistreated males. About half of the respondents reported some form of mistreatment by their fellow students. Conclusion Students in the Faculty of Medicine reported the greatest amount of mistreatment. If a faculty mistreats its students, its success in the main tasks of universities, research, teaching and learning, will be threatened. The results

  18. Association studies in common endocrine diseases (review article

    Directory of Open Access Journals (Sweden)

    Akrami SM

    2007-05-01

    Full Text Available Our understanding of the pathogenesis of endocrine disorders increase rapidly by genetic studies at the molecular level. Common endocrine disorders such as diabetes mellitus, obesity, osteoporosis, dyslipidemia and cancer follow the multifactorial model in the genetic aspect. This review tries to clarify the approach in molecular studies of such diseases for clinicians in different specialties. How to evaluate a possible association between a single nucleotide polymorphism and an endocrinopathy or its complication is the main concern of this review. Two approaches for gene mapping will be discussed as well as main challenges regarding each approach. All such genetic studies ideally include some test of the association between genome sequence variation and the phenotype of interest such as the trait itself, the presence of a given complication, or measures of some endocrinopathy-related intermediate trait. Despite different advances in this analysis, there are major concerns regarding the overall performance and robustness of genetic association studies. By using powerful new high-throughput methods, further insights to molecular basis of such endocrine disorders can be expected. Close correlation between geneticists and clinicians can effectively bridge between basic sciences and clinical investigations.

  19. The commons from a critical social systems perspective

    Directory of Open Access Journals (Sweden)

    Wolfgang Hofkirchner

    2014-04-01

    Full Text Available Normal 0 21 false false false IT JA X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Cambria; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin; mso-ansi-language:DE; mso-fareast-language:EN-US;} When developing the so-called Salzburg Approach to Information and Communication Technologies (ICTs and Society in the years 2004 to 2010, the sociology of technology the then working group of mine at the University of Salzburg used was based upon a combination of critical thinking and systems thinking – of Critical Theory and Systems Theory. Criticism and systemism both include what I’m used to calling the Logic of the Third. The Logic of the Third is the foundation of a critical social systems theory.  

  20. A Systems Biology Approach Reveals Converging Molecular Mechanisms that Link Different POPs to Common Metabolic Diseases.

    Science.gov (United States)

    Ruiz, Patricia; Perlina, Ally; Mumtaz, Moiz; Fowler, Bruce A

    2016-07-01

    A number of epidemiological studies have identified statistical associations between persistent organic pollutants (POPs) and metabolic diseases, but testable hypotheses regarding underlying molecular mechanisms to explain these linkages have not been published. We assessed the underlying mechanisms of POPs that have been associated with metabolic diseases; three well-known POPs [2,3,7,8-tetrachlorodibenzodioxin (TCDD), 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB 153), and 4,4´-dichlorodiphenyldichloroethylene (p,p´-DDE)] were studied. We used advanced database search tools to delineate testable hypotheses and to guide laboratory-based research studies into underlying mechanisms by which this POP mixture could produce or exacerbate metabolic diseases. For our searches, we used proprietary systems biology software (MetaCore™/MetaDrug™) to conduct advanced search queries for the underlying interactions database, followed by directional network construction to identify common mechanisms for these POPs within two or fewer interaction steps downstream of their primary targets. These common downstream pathways belong to various cytokine and chemokine families with experimentally well-documented causal associations with type 2 diabetes. Our systems biology approach allowed identification of converging pathways leading to activation of common downstream targets. To our knowledge, this is the first study to propose an integrated global set of step-by-step molecular mechanisms for a combination of three common POPs using a systems biology approach, which may link POP exposure to diseases. Experimental evaluation of the proposed pathways may lead to development of predictive biomarkers of the effects of POPs, which could translate into disease prevention and effective clinical treatment strategies. Ruiz P, Perlina A, Mumtaz M, Fowler BA. 2016. A systems biology approach reveals converging molecular mechanisms that link different POPs to common metabolic diseases. Environ

  1. The Integration of Two Healthcare Systems: A Common Healthcare Problem.

    Science.gov (United States)

    Cassatly, Hannah; Cassatly, Michael

    2015-01-01

    The change in reimbursement mandated by the Affordable Care Act is causing a rapid consolidation of the marketplace as well as the delivery of clinical care in a team-based model. This case report examines the successful joining of two clinical teams concurrent with the merger of two healthcare organizations and discusses some of the difficulties encountered. A subsequent discussion focuses on the resolution: the need for physicians to embrace the team concept of healthcare delivery and for healthcare systems to facilitate this transition with team and leadership coaching.

  2. System design description for the LDUA common video end effector system (CVEE)

    International Nuclear Information System (INIS)

    Pardini, A.F.

    1998-01-01

    The Common Video End Effector System (CVEE), system 62-60, was designed by the Idaho National Engineering Laboratory (INEL) to provide the control interface of the various video end effectors used on the LDUA. The CVEE system consists of a Support Chassis which contains the input and output Opto-22 modules, relays, and power supplies and the Power Chassis which contains the bipolar supply and other power supplies. The combination of the Support Chassis and the Power Chassis make up the CVEE system. The CVEE system is rack mounted in the At Tank Instrument Enclosure (ATIE). Once connected it is controlled using the LDUA supervisory data acquisition system (SDAS). Video and control status will be displayed on monitors within the LDUA control center

  3. COMMON CONSOLIDATED TAX BASE SYSTEM: DIFFICULTIES IN DETERMINING A DISTRIBUTION FORMULA FOR THE COMMON CONSOLIDATED TAX BASE

    Directory of Open Access Journals (Sweden)

    DANIELA PÎRVU

    2009-01-01

    Full Text Available Recent trends towards a common European tax policy for the generalcorporate taxation aim at preventing the negative effects of tax competition, especially those ofthe national tax base “migration”, by moving corporate main offices in countries with moreadvantageous systems of taxation. The idea of harmonising corporate taxation constitutes oneof the most important debate topics on the agenda of the European Commission for the moment,and also within specialists’ theoretical approaches. The vast range of such approaches isparticularly relevant for the complexity of the problems that hindering the formula, even if it isonly at a theoretical level separated from the policy feasibility issues, and from widely sharedsolutions.

  4. IRMS to study a common cocaine cutting agent: phenacetin.

    Science.gov (United States)

    Ladroue, Virginie; Dujourdy, Laurence; Besacier, Fabrice; Jame, Patrick

    2017-03-01

    Phenacetin is a pharmaceutical closely related to acetaminophen that has been banned in France for a long time due to its nephritic and carcinogenic adverse effects. It frequently appears in cocaine seizures as a cutting agent. Following both sanitary and intelligence motivations, this molecule was chosen for this study, and stable isotopes seemed to be the most appropriate tool. A total of 228 seized samples were collected over a 6-year period, and 8 standards of known origin were purchased. They were submitted to gas chromatography (GC) or elemental analysis - isotope ratio mass spectrometry (EA-IRMS) measurements, depending on their complexity. Stable isotope ratios of carbon, hydrogen, and nitrogen for a part of the sample set, were acquired. The isotopic values of phenacetin standards acquired from various providers located worldwide are quite spread, which indicates that stable isotopes could be used to discriminate manufacturers. However, the measured values of most of the seized samples are concentrated in a narrow range, tending to demonstrate that phenacetin is smuggled from a single source or similar ones. Consequently, stable isotopes could only be used to exclude that several samples come from a common source. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  5. Quantitative ethnobotanical study of common herbal remedies used ...

    African Journals Online (AJOL)

    standing use of herbal remedies. The present ethnobotanical survey was geared towards documenting and preserving local knowledge pertaining to common medicinal plants (MP) used as therapeutic agents in Mauritius. Methods: Interviews were ...

  6. Genetic diversity study of common bean (Phaseolus vulgaris L ...

    African Journals Online (AJOL)

    SAM

    2014-09-03

    Sep 3, 2014 ... small black wild type to the large white, brown, red and spotted types (Cobley and ..... Accession. North Omo. (A). Hadiya. (B). Metekel. (Dan gure. )(C. ) Shinile (D) .... Origin, domestication and evolution of the common bean ...

  7. Use of the common marmoset to study Burkholderia mallei infection.

    Directory of Open Access Journals (Sweden)

    Tomislav Jelesijevic

    Full Text Available Burkholderia mallei is a host-adapted bacterium that does not persist outside of its equine reservoir. The organism causes the zoonosis glanders, which is endemic in Asia, Africa, the Middle East and South America. Infection by B. mallei typically occurs via the respiratory or percutaneous route, and the most common manifestations are life-threatening pneumonia and bacteremia. Glanders is difficult to diagnose and requires prolonged antibiotic therapy with low success rates. There is no vaccine to protect against B. mallei and there is concern regarding its use as a biothreat agent. Thus, experiments were performed to establish a non-human primate model of intranasal infection to study the organism and develop countermeasures. Groups of marmosets (Callithrix jacchus were inoculated intranasally with B. mallei strain ATCC 23344 and monitored for clinical signs of illness for up to 13 days. We discovered that 83% of marmosets inoculated with doses of 2.5 X 10(4 to 2.5 X 10(5 bacteria developed acute lethal infection within 3-4 days. Signs of disease were severe and included lethargy, inappetence, conjunctivitis, mucopurulent and hemorrhagic nasal discharges, and increased respiratory effort with abdominal lifts. Burkholderia mallei was cultured from the lungs, spleen and liver of these animals, and pathologic examination of tissues revealed lesions characteristic of glanders. Challenge experiments also revealed that 91% of animals infected with doses ranging from 25 to 2.5 X 10(3 bacteria exhibited mild non-specific signs of illness and were culture negative. One marmoset inoculated with 2.5 X 10(3 organisms developed moderate signs of disease and reached humane end-points 8 days post-infection. The liver and spleen of this animal were colonized with the agent and pathological analysis of tissues showed nasal, splenic and hepatic lesions. Taken together, these data indicate that the marmoset is a suitable model to study respiratory infection by B

  8. Investigation on the Nonlinear Control System of High-Pressure Common Rail (HPCR) System in a Diesel Engine

    Science.gov (United States)

    Cai, Le; Mao, Xiaobing; Ma, Zhexuan

    2018-02-01

    This study first constructed the nonlinear mathematical model of the high-pressure common rail (HPCR) system in the diesel engine. Then, the nonlinear state transformation was performed using the flow’s calculation and the standard state space equation was acquired. Based on sliding-mode variable structure control (SMVSC) theory, a sliding-mode controller for nonlinear systems was designed for achieving the control of common rail pressure and the diesel engine’s rotational speed. Finally, on the simulation platform of MATLAB, the designed nonlinear HPCR system was simulated. The simulation results demonstrate that sliding-mode variable structure control algorithm shows favorable control performances and overcome the shortcomings of traditional PID control in overshoot, parameter adjustment, system precision, adjustment time and ascending time.

  9. Does the commonly used pH-stat method with back titration really quantify the enzymatic digestibility of lipid drug delivery systems? A case study on solid lipid nanoparticles (SLN).

    Science.gov (United States)

    Heider, Martha; Hause, Gerd; Mäder, Karsten

    2016-12-01

    Enzymatic digestion of lipid drug carriers is very important. Commonly, pancreatin induced formation of fatty acids is monitored by the pH-stat method, which provides a fast, but unspecific readout. However, according to the literature, the pKa values of long chain fatty acids are strongly dependent on the local environment and might vary between 4.2 and 10.15. The high pKa values would lead to an incomplete detection of the lipid digestion and false results. In order to investigate these issues in more detail, we produced cetyl palmitate solid lipid nanoparticles (CP-SLN) stabilized with poloxamer 188 or polysorbate 80. The digestion of CP-SLN was investigated by two different and independent readouts. A HPTLC assay was used in addition to the pH-stat method (with or without back titration). An incomplete digestion of CP-SLN was observed with all methods. Partial digestion of polysorbate 80 contributed to the formation of fatty acids. Depending on the investigated system and the experimental conditions (FaSSIF or FeSSIF) the results of both readout methods were comparable or not. For example, in FeSSIF conditions, the values detected by HPTLC were roughly twice as high as the pH-stat results. Our findings on solid lipids agree with data from Helbig et al. on lipid emulsions, where a gas chromatography method detected much higher values than the pH-stat assay (Food Hydrocoll. 28 (2012) 10-19). The results of our pH-stat experiments with back titration at different pH values showed increased values for fatty acids from pH 7.5 to pH 10. The values obtained by back titration at high pH values (pH 9 or higher) did exceed the digestion values measured by HPTLC. Therefore, we conclude that the pH-stat method might give the same results as more specific reference methods, but it might also both under- (without back titration) or overestimate (with back titration) the enzymatic digestion of lipid drug delivery systems. A further outcome of our study was the proof that

  10. Fine tuning of work practices of common radiological investigations performed using computed radiography system

    International Nuclear Information System (INIS)

    Livingstone, Roshan S.; Timothy Peace, B.S.; Sunny, S.; Victor Raj, D.

    2007-01-01

    Introduction: The advent of the computed radiography (CR) has brought about remarkable changes in the field of diagnostic radiology. A relatively large cross-section of the human population is exposed to ionizing radiation on account of common radiological investigations. This study is intended to audit radiation doses imparted to patients during common radiological investigations involving the use of CR systems. Method: The entrance surface doses (ESD) were measured using thermoluminescent dosimeters (TLD) for various radiological investigations performed using the computed radiography (CR) systems. Optimization of radiographic techniques and radiation doses was done by fine tuning the work practices. Results and conclusion: Reduction of radiation doses as high as 47% was achieved during certain investigations with the use of optimized exposure factors and fine-tuned work practices

  11. Seed quality of common bean accessions under organic and conventional farming systems

    Directory of Open Access Journals (Sweden)

    Diego Medeiros Gindri

    2017-06-01

    Full Text Available Agrobiodiversity is essential for a sustainable food production, and the knowledge of the potential characteristics of landrace seeds may prompt farmers to adopt the habit of seed conservation for this species. This study aimed at categorizing landrace and commercial common bean (Phaseolus vulgaris L. accessions, according to the physiological quality (viability and vigor of seeds produced in the field, during two growing seasons, under organic and conventional farming systems. Germination percentage, field emergence, electrical conductivity, accelerated aging, cold test and seedling length were assessed. The landrace bean accessions exhibit diversity in the physiological seed quality, in terms of their viability and vigor. No differences were observed between the farming systems, in relation to the physiological quality of the seeds produced. The categorization of landrace common bean accessions allows to identify those with superior physiological seed quality.

  12. Genetic diversity studies in common bean ( Phaseolus vulgaris L ...

    African Journals Online (AJOL)

    Molecular characterization of thirteen common bean genotypes was done with random amplified polymorphic DNA (RAPD) markers. Initially, 15 primers were screened out of which only seven were selected which generated a total of 65 amplification products out of which 63 bands (96.62%) were polymorphic indicating fair ...

  13. Exit, punishment and rewards in commons dilemmas: an experimental study.

    Directory of Open Access Journals (Sweden)

    Giangiacomo Bravo

    Full Text Available Commons dilemmas are interaction situations where a common good is provided or exploited by a group of individuals so that optimal collective outcomes clash with private interests. Although in these situations, social norms and institutions exist that might help individuals to cooperate, little is known about the interaction effects between positive and negative incentives and exit options by individuals. We performed a modified public good game experiment to examine the effect of exit, rewards and punishment, as well as the interplay between exit and rewards and punishment. We found that punishment had a stronger effect than rewards on cooperation if considered by itself, whereas rewards had a stronger effect when combined with voluntary participation. This can be explained in terms of the 'framing effect', i.e., as the combination of exit and rewards might induce people to attach higher expected payoffs to cooperative strategies and expect better behaviour from others.

  14. MRI system scoring for differentiation of malignant versus benign stricture of the common bile duct

    Directory of Open Access Journals (Sweden)

    Savastano S

    2016-11-01

    Full Text Available The purpose of this study was to evaluate the ability of magnetic resonance imaging (MRI to differentiate between malignant and benign strictures of the common bile duct by using a scoring system. MRI scans of 34 patients with indeterminate biliary stricture on prior imaging were reviewed; non-enhanced MRI, magnetic resonance cholangiopancreatography (MRCP, diffusion weighted imaging, and contrast-enhanced MRIs were considered for analysis. Ten radiologic findings were significant for malignancy: luminal irregularity, post-contrast conspicuity, high signal intensity on diffusion weighted MRI, luminal stenosis asymmetry, T2-weighted MRI signal intensity, indistinct outer border, abrupt stenosis, bile duct dilatation ≥ 12.5 mm, stenosis length ≥ 10.5 mm, and wall thickness ≥ 4.5 mm. Since none of these findings was pathognomonic for malignancy, a simple system scoring based on statistically significant findings was developed, where each of the above findings counts for one point. A score of 6 or higher was found only in patients with a malignant stricture of the common bile duct; 70% of patients with a benign stenosis had a score of 1, or 2, and all patients with benign lesions had scores of less than 5. This MRI scoring system can assist in the differential diagnosis of common bile duct stricture with high accuracy; to be widely applicable, the MRI score needs to be validated in a prospective patient population.

  15. Diversity and MIMO Performance Evaluation of Common Phase Center Multi Element Antenna Systems

    Directory of Open Access Journals (Sweden)

    V. Papamichael

    2008-06-01

    Full Text Available The diversity and Multiple Input Multiple Output (MIMO performance provided by common phase center multi element antenna (CPCMEA systems is evaluated using two practical methods which make use of the realized active element antenna patterns. These patterns include both the impact of the mutual coupling and the mismatch power loss at antenna ports. As a case study, two and four printed Inverted F Antenna (IFA systems are evaluated by means of Effective Diversity Gain (EDG and Capacity (C. EDG is measured in terms of the signal-to-noise ratio (SNR enhancement at a specific outage probability and in terms of the SNR reduction for achieving a desired average bit error rate (BER. The concept of receive antenna selection in MIMO systems is also investigated and the simulation results show a 43% improvement in the 1% outage C of a reconfigurable 2x2 MIMO system over a fixed 2x2 one.

  16. Single Nucleotide Polymorphisms in Common Bean: Their Discovery and Genotyping Using a Multiplex Detection System

    Directory of Open Access Journals (Sweden)

    E. Gaitán-Solís

    2008-11-01

    Full Text Available Single nucleotide polymorphism (SNP markers are by far the most common form of DNA polymorphism in a genome. The objectives of this study were to discover SNPs in common bean ( L. by comparing sequences from coding and noncoding regions obtained from the GenBank and genomic DNA and to compare sequencing results with those obtained using single base extension (SBE assays on the Luminex-100 system for use in high-throughput germplasm evaluation. We assessed the frequency of SNPs in 47 fragments of common bean DNA, using SBE as the evaluation methodology. We conducted a sequence analysis of 10 genotypes of cultivated and wild beans belonging to the Mesoamerican and Andean genetic pools of . For the 10 genotypes evaluated, a total of 20,964 bp of sequence were analyzed in each genotype and compared, resulting in the discovery of 239 SNPs and 133 InDels, giving an average SNP frequency of one per 88 bp and an InDel frequency of one per 157 bp. This is the equivalent of a nucleotide diversity (θ of 6.27 × 10. Comparisons with the SNP genotypes previously obtained by direct sequencing showed that the SBE assays on the Luminex-100 were accurate, with 2.5% being miscalled and 1% showing no signal. These results indicate that the Luminex-100 provides a high-throughput system that can be used to analyze SNPs in large samples of genotypes both for purposes of assessing diversity and also for mapping studies.

  17. Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies

    NARCIS (Netherlands)

    López-Isac, Elena; Martín, Jose Ezequiel; Assassi, Shervin; Simeón, Carmen P.; Carreira, Patricia; Ortego-Centeno, Norberto; Freire, Mayka; Beltrán, Emma; Narváez, Javier; Alegre-Sancho, Juan J.; Fernández-Gutiérrez, Benjamín; Balsa, Alejandro; Ortiz, Ana M.; González-Gay, Miguel A.; Beretta, Lorenzo; Santaniello, Alessandro; Bellocchi, Chiara; Lunardi, Claudio; Moroncini, Gianluca; Gabrielli, Armando; Witte, Torsten; Hunzelmann, Nicolas; Distler, Jörg H W; Riekemasten, Gabriella; van der Helm-van Mil, Annette H.; de Vries-Bouwstra, Jeska; Magro-Checa, Cesar; Voskuyl, Alexandre E.; Vonk, Madelon C.; Molberg, Øyvind; Merriman, Tony; Hesselstrand, Roger; Nordin, Annika; Padyukov, Leonid; Herrick, Ariane; Eyre, Steve; Koeleman, Bobby P C; Denton, Christopher P.; Fonseca, Carmen; Radstake, Timothy R D J; Worthington, Jane; Mayes, Maureen D.; Martín, Javier; Ríos, Raquel; Callejas, Jose Luis; Hitos, José Antonio Vargas; Portales, Rosa García; Camps, María Teresa; Fernández-Nebro, Antonio; González-Escribano, María F.; García-Hernández, Francisco José; Castillo, Ma Jesús; Ángeles Aguirre, Ma; Gómez-Gracia, Inmaculada; Rodríguez-Rodríguez, Luis; Peña, Paloma García de la; Vicente, Esther; Andreu, José Luis; de Castro, Mónica Fernández; López-Longo, Francisco Javier; Martínez, Lina; Fonollosa, Vicente; Guillén, Alfredo; Castellví, Iván; Espinosa, Gerard; Tolosa, Carlos; Pros, Anna; Carballeira, Mónica Rodríguez; Narváez, Francisco Javier; Rivas, Manel Rubio; Ortiz-Santamaría, Vera; Madroñero, Ana Belén; Díaz, Bernardino; Trapiella, Luis; Sousa, Adrián; Egurbide, María Victoria; Mateo, Patricia Fanlo; Sáez-Comet, Luis; Díaz, Federico; Hernández, Vanesa; Beltrán, Emma; Román-Ivorra, José Andrés; Grau, Elena; Alegre-Sancho, Juan José; Blanco García, Francisco J.; Oreiro, Natividad

    2016-01-01

    Objective: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc–RA genetic loci have been identified independently. The aim of the current study was to systematically search for new

  18. Reliability analysis of the auxiliary feedwater system of Angra-1 including common cause failures using the multiple greek letter model

    International Nuclear Information System (INIS)

    Lapa, Celso Marcelo Franklin.

    1996-05-01

    The use of redundancy to increase the reliability of industrial systems make them subject to the occurrence of common cause events. The industrial experience and the results of safety analysis studies have indicated that common cause failures are the main contributors to the unreliability of plants that have redundant systems, specially in nuclear power plants. In this Thesis procedures are developed in order to include the impact of common cause failures in the calculation of the top event occurrence probability of the Auxiliary Feedwater System in a typical two-loop Nuclear Power Plant (PWR). For this purpose the Multiple Greek Letter Model is used. (author). 14 refs., 10 figs., 11 tabs

  19. Productivity Losses and Costs in the Less-Common Systemic Autoimmune Rheumatic Diseases.

    Science.gov (United States)

    McCormick, Natalie; Marra, Carlo A; Aviña-Zubieta, J Antonio

    2017-10-30

    We synthesised the literature on productivity losses and costs in the less-common systemic autoimmune rheumatic diseases: Sjogren's syndrome (SjS), systemic sclerosis (SSc), poly/dermatomyositis (PM/DM), and systemic vasculitides (SV). Of 29 studies located, 12 were published 2012 onwards (SSc = 6, SjS = 2, PM/DM = 2, SV = 2). In these, 25% of PM/DM, and 21-26% of SV, were work disabled, 22% of SSc stopped work within 3 years of diagnosis, and annual costs of absenteeism in SSc averaged $12,024 2017 USD. Very few studies reported on costs, presenteeism (working at reduced levels), or unpaid productivity loss. Across multiple systemic autoimmune rheumatic diseases (SARDs), major drivers of lost productivity were generalised items like pain, depression, and fatigue, rather than disease-specific factors. Evidence suggests that work disability is common in SSc and strikes quickly. However, in SSc and other SARDs, more comprehensive estimates are needed, which include absenteeism and presenteeism from paid and unpaid work, costs, and drivers of productivity loss.

  20. Modelling of the work processes high-pressure pump of common rail diesel injection system

    Directory of Open Access Journals (Sweden)

    Botwinska Katarzyna

    2016-01-01

    Full Text Available Common rail injection systems are becoming a more widely used solution in the fuel systems of modern diesel engines. The main component and the characteristic feature of the system is rail injection of the fuel under high pressure, which is passed to the injector and further to the combustion chamber. An important element in this process is the high-pressure pump, continuing adequate pressure in the rail injection system. Common rail (CR systems are being modified in order to optimise their work and virtual simulations are a useful tool in order to analyze the correctness of operation of the system while varying the parameters and settings, without any negative impact on the real object. In one particular study, a computer simulation of the pump high-pressure CR system was made in MatLab environment, based on the actual dimensions of the object – a one-cylinder diesel engine, the Farymann Diesel 18W. The resulting model consists of two parts – the first is responsible for simulating the operation of the high-pressure pump, and the second responsible for simulation of the remaining elements of the CR system. The results of this simulation produced waveforms of the following parameters: fluid flow from the manifold to the injector [m3/s], liquid flow from the manifold to the atmosphere [m3/s], and manifold pressure [Pa]. The simulation results allow for a positive verification of the model and the resulting system could become a useful element of simulation of the entire position and control algorithm.

  1. Electron microscopical studies of the common bile duct in reindeer

    Directory of Open Access Journals (Sweden)

    Timo Rahko

    1990-08-01

    Full Text Available In a previous publication the authors have described some ultrastructural characteristics of granulated cells in the common bile duct of the reindeer. On the basis of the same material, electron microscopic observations on other tissue elements of bile duct wall are now reported. The surface and glandular epithelium were composed of tall columnar epithelial cells with villous structures on the luminal surfaces. The parietal cytoplasmic membranes of epithelial cells were equipped with intercellular desmosomes while intraepithelial globule leucocytes did not form any junctional complex with other cells. Apical cytoplasmic areas of superficial epithelial cells showed electron-dense small bodies possibly consisting of mucinous substances. The goblet and deep glandular cells, on the other hand, contained numerous large mucin granules with less electron-dense matrices. It appears that their secretions are more abundant than those in superficial epithelial cells which obviously are absorptive as their main function. The nuclei and other cytoplasmic organelles showed profiles similar to those in epithelial cells generally. The lumen of the bile ducts was usually empty or contained fine-granular or amorphous material. An unusual feature was the presence of parts of globule leucocytes or even almost whole cells occurring freely in ductal secretions.Elektronimikroskooppinen tutkimus yhteisen sappikäytävän rakenteesta porolla.Abstract in Finnish / Yhteenveto: Aikaisemmassa julkaisussa tekijät kuvasivat poron yhteisen sappikäytävän (ductus hepaticus communis seinämän jyväsellisten solujen hienorakennetta. Tässä artikkelissa selostetaan saman aineiston perusteella (6 tervettä teurasporoa elektronimikroskooppisia havaintoja sappikäytäväseinämän muista kudosrakenteista. Sappikäytäväseinämän pinta- ja rauhasepiteeli koostuu korkeista epiteelisoluista. Pinnallisia epiteelisoluja kattavat säännölliset mikrovillukset, ja niillä on vain v

  2. Impact of a hospitalist system on length of stay and cost for children with common conditions.

    Science.gov (United States)

    Srivastava, Rajendu; Landrigan, Christopher P; Ross-Degnan, Dennis; Soumerai, Stephen B; Homer, Charles J; Goldmann, Donald A; Muret-Wagstaff, Sharon

    2007-08-01

    This study examined mechanisms of efficiency in a managed care hospitalist system on length of stay and total costs for common pediatric conditions. We conducted a retrospective cohort study (October 1993 to July 1998) of patients in a not-for-profit staff model (HMO 1) and a non-staff-model (HMO 2) managed care organization at a freestanding children's hospital. HMO 1 introduced a hospitalist system for patients in October 1996. Patients were included if they had 1 of 3 common diagnoses: asthma, dehydration, or viral illness. Linear regression models examining length-of-stay-specific costs for prehospitalist and posthospitalist systems were built. Distribution of length of stay for each diagnosis before and after the system change in both study groups was calculated. Interrupted time series analysis tested whether changes in the trends of length of stay and total costs occurred after implementation of the hospitalist system by HMO1 (HMO 2 as comparison group) for all 3 diagnoses combined. A total of 1970 patients with 1 of the 3 study conditions were cared for in HMO 1, and 1001 in HMO 2. After the hospitalist system was introduced in HMO 1, length of stay was reduced by 0.23 days (13%) for asthma and 0.19 days (11%) for dehydration; there was no difference for patients with viral illness. The largest relative reduction in length of stay occurred in patients with a shorter length of stay whose hospitalizations were reduced from 2 days to 1 day. This shift resulted in an average cost-per-case reduction of $105.51 (9.3%) for patients with asthma and $86.22 (7.8%) for patients with dehydration. During the same period, length of stay and total cost rose in HMO 2. Introduction of a hospitalist system in one health maintenance organization resulted in earlier discharges and reduced costs for children with asthma and dehydration compared with another one, with the largest reductions occurring in reducing some 2-day hospitalizations to 1 day. These findings suggest that

  3. Joint Polar Satellite System (JPSS) Common Ground System (CGS) Current Technical Performance Measures

    Science.gov (United States)

    Cochran, S.; Panas, M.; Jamilkowski, M. L.; Miller, S. W.

    2015-12-01

    ABSTRACT The National Oceanic and Atmospheric Administration (NOAA) and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation civilian weather and environmental satellite system: the Joint Polar Satellite System (JPSS). The Joint Polar Satellite System will replace the afternoon orbit component and ground processing system of the current Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA. The JPSS satellites will carry a suite of sensors designed to collect meteorological, oceanographic, climatological and geophysical observations of the Earth. The ground processing system for JPSS is known as the JPSS Common Ground System (JPSS CGS). Developed and maintained by Raytheon Intelligence, Information and Services (IIS), the CGS is a multi-mission enterprise system serving NOAA, NASA and their national and international partners. The CGS has demonstrated its scalability and flexibility to incorporate multiple missions efficiently and with minimal cost, schedule and risk, while strengthening global partnerships in weather and environmental monitoring. The CGS architecture is being upgraded to Block 2.0 in 2015 to "operationalize" S-NPP, leverage lessons learned to date in multi-mission support, take advantage of more reliable and efficient technologies, and satisfy new requirements and constraints in the continually evolving budgetary environment. To ensure the CGS meets these needs, we have developed 49 Technical Performance Measures (TPMs) across 10 categories, such as data latency, operational availability and scalability. This paper will provide an overview of the CGS Block 2.0 architecture, with particular focus on the 10 TPM categories listed above. We will provide updates on how we ensure the deployed architecture meets these TPMs to satisfy our multi-mission objectives with the deployment of Block 2.0.

  4. A common-path phase-shift interferometry surface plasmon imaging system

    Science.gov (United States)

    Su, Y.-T.; Chen, Shean-Jen; Yeh, T.-L.

    2005-03-01

    A biosensing imaging system is proposed based on the integration of surface plasmon resonance (SPR) and common-path phase-shift interferometry (PSI) techniques to measure the two-dimensional spatial phase variation caused by biomolecular interactions upon a sensing chip. The SPR phase imaging system can offer high resolution and high-throughout screening capabilities to analyze microarray biomolecular interaction without the need for additional labeling. With the long-term stability advantage of the common-path PSI technique even with external disturbances such as mechanical vibration, buffer flow noise, and laser unstable issue, the system can match the demand of real-time kinetic study for biomolecular interaction analysis (BIA). The SPR-PSI imaging system has achieved a detection limit of 2×10-7 refraction index change, a long-term phase stability of 2.5x10-4π rms over four hours, and a spatial phase resolution of 10-3 π with a lateral resolution of 100μm.

  5. Comprehensive method of common-mode failure analysis for LMFBR safety systems

    International Nuclear Information System (INIS)

    Unione, A.J.; Ritzman, R.L.; Erdmann, R.C.

    1976-01-01

    A technique is demonstrated which allows the systematic treatment of common-mode failures of safety system performance. The technique uses log analysis in the form of fault and success trees to qualitatively assess the sources of common-mode failure and quantitatively estimate the contribution to the overall risk of system failure. The analysis is applied to the secondary control rod system of an early sized LMFBR

  6. Multi-centre, multi-database studies with common protocols

    DEFF Research Database (Denmark)

    Klungel, Olaf H.; Kurz, Xavier; de Groot, Mark C.H.

    2016-01-01

    was observed depending on design, exposure and outcome definitions, but none of the differences were statistically significant. The association between anti-epileptics and suicidality was inconsistent across the UK CPRD, Danish National registries and the French PGRx system. Calcium channel blockers were...

  7. Study on common phenotypic traits for purchasing sheep and their ...

    African Journals Online (AJOL)

    selected sheep purchased for various purposes were studied. The study methods ... household economy in many countries. Ethiopia has ... Among these are mentioned skull morphology and size, body length, wither height, ear and tail length ...

  8. Effect of a certain class of potential common mode failures on the reliability of redundant systems

    International Nuclear Information System (INIS)

    Apostolakis, G.E.

    1975-11-01

    This is a theoretical investigation of the importance of common mode failures on the reliability of redundant systems. These failures are assumed to be the result of fatal shocks (e.g., from earthquakes, explosions, etc.) which occur at a constant rate. This formulation makes it possible to predict analytically results obtained in the past which showed that the probability of a common mode failure of the redundant channels of the protection system of a typical nuclear power plant was orders of magnitude larger than the probability of failure from chance failures alone. Furthermore, since most reliability analyses of redundant systems do not include potential common mode failures in the probabilistic calculations, criteria are established which can be used to decide either that the common-mode-failure effects are indeed insignificant or that such calculations are meaningless, and more sophisticated methods of analysis are required, because common mode failures cannot be ignored

  9. Inuit Social Studies: A Variant on a Common Theme.

    Science.gov (United States)

    Wolforth, John

    1998-01-01

    A social studies methods course for preservice Inuit student teachers in Canada mediated between the knowledge and professional skills required of social studies teachers as presented in the textbook and the knowledge brought by the Inuit students. Using genealogy, concept webs, and timelines, the instructor gave Inuit knowledge as much weight as…

  10. The Role of Sharia Judges in Indonesia: Between The Common Law and The Civil Law Systems

    Directory of Open Access Journals (Sweden)

    Alfitri

    2017-12-01

    Full Text Available This article seeks to analyse the role of Religious Courts’ (Pengadilan Agama or PA Judges in the formation of Islamic law in Indonesia. As part of the civil legal system, PA Judges are bound by legal provisions in handling legal disputes in court. They must apply the applicable legal provisions to decide upon a case. This condition can also be understood from the aspect of appointment of judges in Indonesia, including PA Judges, which is conducted not through professional career path as in the common law system. Thus, they are appointed from a new graduate of law/sharia faculty and then trained, inter alia, to apply and/or interpret applicable laws (legislation; and not to make the law itself. However, on the basis of secondary data analysis, studies on the ijtihad of PA Judges reveal that they are no longer only fixated on the provisions of statutes in deciding cases. They also make laws, cases in point are the Compilation of Islamic Law (KHI and the Compilation of Sharia Economic Law (KHES, do ijtihad on the books of fiqh which became the basis for the drafting of Islamic legislation in Indonesia. Some of them even do direct ijtihad from Sharia sources, namely the Qur'an and Hadith. This condition is arguably more in accordance with the character of judges (qadis in Islamic history which on a certain level similar to the role of judges in common law system.

  11. Adding a Mission to the Joint Polar Satellite System (JPSS) Common Ground System (CGS)

    Science.gov (United States)

    Miller, S. W.; Grant, K. D.; Jamilkowski, M. L.

    2014-12-01

    The National Oceanic and Atmospheric Administration (NOAA) and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation civilian weather and environmental satellite system: the Joint Polar Satellite System (JPSS). The Joint Polar Satellite System will replace the afternoon orbit component and ground processing system of the current Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA. The JPSS satellites will carry a suite of sensors designed to collect meteorological, oceanographic, climatological and geophysical observations of the Earth. The ground processing system for JPSS is known as the JPSS Common Ground System (JPSS CGS). Developed and maintained by Raytheon Intelligence, Information and Services (IIS), the CGS is a multi-mission enterprise system serving NOAA, NASA and their national and international partners. The CGS provides a wide range of support to a number of missions: 1) Command and control and mission management for the Suomi National Polar-orbiting Partnership (S-NPP) mission today, expanding this support to the JPSS-1 satellite and the Polar Free Flyer mission in 2017 2) Data acquisition via a Polar Receptor Network (PRN) for S-NPP, the Japan Aerospace Exploration Agency's (JAXA) Global Change Observation Mission - Water (GCOM-W1), POES, and the Defense Meteorological Satellite Program (DMSP) and Coriolis/WindSat for the Department of Defense (DoD) 3) Data routing over a global fiber Wide Area Network (WAN) for S-NPP, JPSS-1, Polar Free Flyer, GCOM-W1, POES, DMSP, Coriolis/WindSat, the NASA Space Communications and Navigation (SCaN, which includes several Earth Observing System [EOS] missions), MetOp for the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT), and the National Science Foundation (NSF) 4) Environmental data processing and distribution for S-NPP, GCOM-W1 and JPSS-1 With this established infrastructure and existing suite of missions, the CGS

  12. Ten years of common-rail injection systems for passenger cars; Gemeine Drucksache. Zehn Jahre Common-Rail-Einspritzsystem fuer Pkw

    Energy Technology Data Exchange (ETDEWEB)

    Hohenthal, M.Y. von

    2007-07-15

    The future of the diesel engine started in 1997 with the Bosch common rail injection system which provided higher power, higher rotary momentum, lower consumption, lower noise and lower pollutant emissions. Since then, high-pressure common-rail injection systems have become state of the art. (orig.)

  13. Is There a Canonical Cortical Circuit for the Cholinergic System? Anatomical Differences Across Common Model Systems.

    Science.gov (United States)

    Coppola, Jennifer J; Disney, Anita A

    2018-01-01

    Acetylcholine (ACh) is believed to act as a neuromodulator in cortical circuits that support cognition, specifically in processes including learning, memory consolidation, vigilance, arousal and attention. The cholinergic modulation of cortical processes is studied in many model systems including rodents, cats and primates. Further, these studies are performed in cortical areas ranging from the primary visual cortex to the prefrontal cortex and using diverse methodologies. The results of these studies have been combined into singular models of function-a practice based on an implicit assumption that the various model systems are equivalent and interchangeable. However, comparative anatomy both within and across species reveals important differences in the structure of the cholinergic system. Here, we will review anatomical data including innervation patterns, receptor expression, synthesis and release compared across species and cortical area with a focus on rodents and primates. We argue that these data suggest no canonical cortical model system exists for the cholinergic system. Further, we will argue that as a result, care must be taken both in combining data from studies across cortical areas and species, and in choosing the best model systems to improve our understanding and support of human health.

  14. Is There a Canonical Cortical Circuit for the Cholinergic System? Anatomical Differences Across Common Model Systems

    Directory of Open Access Journals (Sweden)

    Jennifer J. Coppola

    2018-01-01

    Full Text Available Acetylcholine (ACh is believed to act as a neuromodulator in cortical circuits that support cognition, specifically in processes including learning, memory consolidation, vigilance, arousal and attention. The cholinergic modulation of cortical processes is studied in many model systems including rodents, cats and primates. Further, these studies are performed in cortical areas ranging from the primary visual cortex to the prefrontal cortex and using diverse methodologies. The results of these studies have been combined into singular models of function—a practice based on an implicit assumption that the various model systems are equivalent and interchangeable. However, comparative anatomy both within and across species reveals important differences in the structure of the cholinergic system. Here, we will review anatomical data including innervation patterns, receptor expression, synthesis and release compared across species and cortical area with a focus on rodents and primates. We argue that these data suggest no canonical cortical model system exists for the cholinergic system. Further, we will argue that as a result, care must be taken both in combining data from studies across cortical areas and species, and in choosing the best model systems to improve our understanding and support of human health.

  15. Academy : Collaborative Curriculum Case Studies - iCommons ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Leaders in the area of open learning content met in Toronto in June 2006 to ... studies exploring the challenges faced by open and collaborative curriculum projects ... long-term climate action to reduce social inequality, promote greater gender ...

  16. Creation of a common information system on the Republic of Kazakhstan radiation hazardous objects

    International Nuclear Information System (INIS)

    Kadyrzhanov, K.K.; Kuterbekov, K.A.; Lukashenko, S.N.; Morenko, V.S.; Glushchenko, V.N.

    2005-01-01

    Works on creation of a common information system on the Republic of Kazakhstan territory radiation hazardous objects for providing of radiation situation control and stewardship decision making under nature-conservative measures conducting are considered. The information system is forming on the base of up-to-date GIS system - ArcGIS - and incorporates two databases - geographical and attributive

  17. Genetic diversity study of common bean ( Phaseolus vulgaris L ...

    African Journals Online (AJOL)

    In PCoA, majority individuals of Metekel (L) tended to form separate group. The result of the study confirmed the presence of genetic diversity that can be exploited to improve the productivity. This calls for a conserted efforts in the collection, conservation and sustainable use of P. vulgaris. Keywords: Genetic diversity, ISSR, ...

  18. ANALYSIS OF RELIABILITY OF NONRECTORABLE REDUNDANT POWER SYSTEMS TAKING INTO ACCOUNT COMMON FAILURES

    Directory of Open Access Journals (Sweden)

    V. A. Anischenko

    2014-01-01

    Full Text Available Reliability Analysis of nonrestorable redundant power Systems of industrial plants and other consumers of electric energy was carried out. The main attention was paid to numbers failures influence, caused by failures of all elements of System due to one general reason. Noted the main possible reasons of common failures formation. Two main indicators of reliability of non-restorable systems are considered: average time of no-failure operation and mean probability of no-failure operation. Modeling of failures were carried out by mean of division of investigated system into two in-series connected subsystems, one of them indicated independent failures, but the other indicated common failures. Due to joined modeling of single and common failures resulting intensity of failures is the amount incompatible components: intensity statistically independent failures and intensity of common failures of elements and system in total.It is shown the influence of common failures of elements on average time of no-failure operation of system. There is built the scale of preference of systems according to criterion of  average time maximum of no-failure operation, depending on portion of common failures. It is noticed that such common failures don’t influence on the scale of preference, but  change intervals of time, determining the moments of systems failures and excepting them from the number of comparators. There were discussed two problems  of conditionally optimization of  systems’  reservation choice, taking into account their reliability and cost. The first problem is solved due to criterion of minimum cost of system providing mean probability of no-failure operation, the second problem is solved due to criterion of maximum of mean probability of no-failure operation with cost limitation of system.

  19. RAPD study on some common species of Porphyra in China

    Science.gov (United States)

    Kuang, Mei; Wang, Su-Juan; Li, Yao; Shen, Da-Leng; Zeng, Cheng-Kui

    1998-03-01

    RAPD analysis of seven samples of five Porphyra species, P haitanensis (three samples of cultured population), P. katadai var. hemiphylla, P. oligospermatangia, P. suborbiculata and P. yezoensis, showed the closest relationship existing among the three cultured populations of P. haitanensis. The genetic distance between P. haitanensis and P. oligospermatangia was the same as that between P. haitanensis and P. suborbiculata, both were 0.9. The genetic distances, among the other species of Porphyra ranged from 0.7 to 0.8. UPGMA analysis showed P. suborbiculata and P. yezoensis belong to another lineage. Results of this study suggests that RAPD analysis is effective at population level.

  20. Use of common time base for checkpointing and rollback recovery in a distributed system

    Science.gov (United States)

    Ramanathan, Parameswaran; Shin, Kang G.

    1993-01-01

    An approach to checkpointing and rollback recovery in a distributed computing system using a common time base is proposed. A common time base is established in the system using a hardware clock synchronization algorithm. This common time base is coupled with the idea of pseudo-recovery points to develop a checkpointing algorithm that has the following advantages: reduced wait for commitment for establishing recovery lines, fewer messages to be exchanged, and less memory requirement. These advantages are assessed quantitatively by developing a probabilistic model.

  1. Joint Polar Satellite System (JPSS) Common Ground System (CGS) Overview and Architectural Tenets

    Science.gov (United States)

    Miller, S. W.; Grant, K. D.; Jamilkowski, M. L.

    2013-12-01

    The National Oceanic and Atmospheric Administration (NOAA) and National Aeronautics and Space Administration (NASA) are jointly acquiring the next-generation civilian weather and environmental satellite system: the Joint Polar Satellite System (JPSS). The Joint Polar Satellite System will replace the afternoon orbit component and ground processing system of the current Polar-orbiting Operational Environmental Satellites (POES) managed by NOAA. The JPSS satellites will carry a suite of sensors designed to collect meteorological, oceanographic, climatological and geophysical observations of the Earth. The ground processing system for JPSS is known as the JPSS Common Ground System (JPSS CGS). Developed and maintained by Raytheon Intelligence and Information Systems (IIS), the CGS is a multi-mission enterprise system serving NOAA, NASA and their national and international partners. The CGS provides a wide range of support to a number of missions: 1) Command and control and mission management for the Suomi National Polar Partnership (S-NPP) mission today, expanding this support to the JPSS-1 satellite and the Polar Free Flyer mission in 2017 2) Data acquisition via a Polar Receptor Network (PRN) for S-NPP, the Japan Aerospace Exploration Agency's (JAXA) Global Change Observation Mission - Water (GCOM-W1), POES, and the Defense Meteorological Satellite Program (DMSP) and Coriolis/WindSat for the Department of Defense (DoD) 3) Data routing over a global fiber Wide Area Network (WAN) for S-NPP, JPSS-1, Polar Free Flyer, GCOM-W1, POES, DMSP, Coriolis/WindSat, the NASA Space Communications and Navigation (SCaN, which includes several Earth Observing System [EOS] missions), MetOp for the European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT), and the National Science Foundation (NSF) 4) Environmental data processing and distribution for S-NPP, GCOM-W1 and JPSS-1 The CGS architecture will receive a technology refresh in 2015 to satisfy several key

  2. System of common usage on the base of external memory devices and the SM-3 computer

    International Nuclear Information System (INIS)

    Baluka, G.; Vasin, A.Yu.; Ermakov, V.A.; Zhukov, G.P.; Zimin, G.N.; Namsraj, Yu.; Ostrovnoj, A.I.; Savvateev, A.S.; Salamatin, I.M.; Yanovskij, G.Ya.

    1980-01-01

    An easily modified system of common usage on the base of external memories and a SM-3 minicomputer replacing some pulse analysers is described. The system has merits of PA and is more advantageous with regard to effectiveness of equipment using, the possibility of changing configuration and functions, the data protection against losses due to user errors and some failures, price of one registration channel, place occupied. The system of common usage is intended for the IBR-2 pulse reactor computing centre. It is designed using the SANPO system means for SM-3 computer [ru

  3. Detection of Common Problems in Real-Time and Multicore Systems Using Model-Based Constraints

    Directory of Open Access Journals (Sweden)

    Raphaël Beamonte

    2016-01-01

    Full Text Available Multicore systems are complex in that multiple processes are running concurrently and can interfere with each other. Real-time systems add on top of that time constraints, making results invalid as soon as a deadline has been missed. Tracing is often the most reliable and accurate tool available to study and understand those systems. However, tracing requires that users understand the kernel events and their meaning. It is therefore not very accessible. Using modeling to generate source code or represent applications’ workflow is handy for developers and has emerged as part of the model-driven development methodology. In this paper, we propose a new approach to system analysis using model-based constraints, on top of userspace and kernel traces. We introduce the constraints representation and how traces can be used to follow the application’s workflow and check the constraints we set on the model. We then present a number of common problems that we encountered in real-time and multicore systems and describe how our model-based constraints could have helped to save time by automatically identifying the unwanted behavior.

  4. Prophenoloxidase system, lysozyme and protease inhibitor distribution in the common cuttlefish Sepia officinalis.

    Science.gov (United States)

    Le Pabic, Charles; Safi, Georges; Serpentini, Antoine; Lebel, Jean-Marc; Robin, Jean-Paul; Koueta, Noussithé

    2014-01-01

    The immune system of cephalopods remains poorly understood. The aim of this study was to determine the specific activity of immune enzymes in epithelial barriers, circulatory and digestive systems of the common cuttlefish Sepia officinalis. Three enzyme groups with putative functions in immunity were investigated: phenoloxidases (POs), lysozymes and protease inhibitors (PIs). Consistent with a role in immunity, highest PO activities were found in the integument as well as the respiratory and circulatory organs under zymogenic (proPO) and active form. Surprisingly, high PO activities were also found in the digestive gland and its appendages. Similarly, high lysozyme activities were detected in the integument and circulatory organs, but also in the posterior salivary glands, highlighting the implication of this antibacterial enzyme group in most tissues exposed to the environment but also within the circulatory system. Albeit highest in digestive organs, the ubiquitous detection of PI activity in assayed compartments suggests immune function(s) in a wide range of tissues. Our study reports proPO/PO, lysozyme and PI distributions in S. officinalis body compartments for the first time, and thus provides the fundamental basis for a better understanding of the humoral immune system in cephalopods as well as invertebrates. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Systemic interpretation and the judicial recovery of the possibility for companies in common

    Directory of Open Access Journals (Sweden)

    Juliana Hinterlang dos Santos Costa

    2015-06-01

    Full Text Available The Company in common was introduced by Brazilian law from the Civil Code of 2002 in its articles 986 to 990. In the previous period it was analyzed from the irregular company name or company and fact. The first was characterized by having written contract, but this was not brought to registration with the competent body and the second when there was no social contract. This study aims to analyze the figure of the Company in common, in the current legal system, from the majority interpretation that does not recognize the right to judicial recovery. It points out that this interpretation ignores: i principles governing the legal system and the economic subsystem; and ii that the current legislation allows their accountability before legal duties in labor spheres, tax, competitive and consumer. Under these main arguments is that they have highlighted the systematic interpretation to defend the right to judicial or extrajudicial recovery. So effective is legal certainty material.    Arraste e solte o arquivo ou link aqui para traduzir o documento ou a página da Web.Arraste e solte o link aqui para traduzir a página da Web.O tipo de arquivo que você soltou não é suportado. Tente outros tipos de arquivo.O tipo de link que você soltou não é suportado. Tente outros tipos de link. 

  6. Reliability analysis of repairable multi-state system with common bus performance sharing

    International Nuclear Information System (INIS)

    Yu, Huan; Yang, Jun; Mo, Huadong

    2014-01-01

    In this paper, an instantaneous availability model for repairable multi-state system (MSS) with common bus performance sharing is proposed. The repairable MSS consists of some multi-state units and a common bus performance redistribution system. Each unit in the system has several performance levels and must satisfy its individual random demand. A unit can transmit the surplus performance to other units in real time through the common bus performance redistribution system, if it has a performance that exceeds its demand. The entire system fails if the demand of any unit is not satisfied. A new method based on the combination of the stochastic process method and the universal generating function technique is suggested to evaluate the instantaneous availability and the mean instantaneous performance deficiency of the proposed repairable MSS. Two examples are given for applications in the end

  7. Effect of breastfeeding on common pediatric infections: a 5-year prospective cohort study.

    Science.gov (United States)

    Ardiç, Cüneyt; Yavuz, Erdinç

    2018-04-01

    The studies conducted revealed that breastfeeding duration has a reducing effect on common infectious diseases in the children during breastfeeding period. The aim of the present study was to address the association between breastfeeding duration and common infectious diseases in the children until 5 years of age to show long-term protective effects of the breast milk. The study included 411 infants who were born in Rize (Turkey) between January 2011 and December 2011. The present prospective-cohort study lasted for 5 years and 11 interviews were conducted with each mother of the infants during this period. The infants were divided into two groups as those who were breastfed more and less than 12 months and the association between breastfeeding and infections such as acute otitis media, acute gastroenteritis, acute respiratory tract infections and acute urinary system infections was investigated. Of 270 infants 193 (71.5%) were breastfed longer than 12 months and 77 (28.5%) were breastfed less than 12 months. Infants in the first group had less acute otitis media and acute gastroenteritis (n= 77, 28.52%) when compared with the infants breastfed less than 12 months during 5-year period (p <0.05). The present study detected that breastfeeding duration longer than 12 months significantly reduces the common childhood infections such as otitis media and gastroenteritis during the first 5 years of life. Sociedad Argentina de Pediatría.

  8. Probabilistic common cause failure modeling for auxiliary feedwater system after the introduction of flood barriers

    International Nuclear Information System (INIS)

    Zheng, Xiaoyu; Yamaguchi, Akira; Takata, Takashi

    2013-01-01

    Causal inference is capable of assessing common cause failure (CCF) events from the viewpoint of causes' risk significance. Authors proposed the alpha decomposition method for probabilistic CCF analysis, in which the classical alpha factor model and causal inference are integrated to conduct a quantitative assessment of causes' CCF risk significance. The alpha decomposition method includes a hybrid Bayesian network for revealing the relationship between component failures and potential causes, and a regression model in which CCF parameters (global alpha factors) are expressed by explanatory variables (causes' occurrence frequencies) and parameters (decomposed alpha factors). This article applies this method and associated databases needed to predict CCF parameters of auxiliary feedwater (AFW) system when defense barriers against internal flood are introduced. There is scarce operation data for functionally modified safety systems and the utilization of generic CCF databases is of unknown uncertainty. The alpha decomposition method has the potential of analyzing the CCF risk of modified AFW system reasonably based on generic CCF databases. Moreover, the sources of uncertainty in parameter estimation can be studied. An example is presented to demonstrate the process of applying Bayesian inference in the alpha decomposition process. The results show that the system-specific posterior distributions for CCF parameters can be predicted. (author)

  9. Detailed requirements document for common software of shuttle program information management system

    Science.gov (United States)

    Everette, J. M.; Bradfield, L. D.; Horton, C. L.

    1975-01-01

    Common software was investigated as a method for minimizing development and maintenance cost of the shuttle program information management system (SPIMS) applications while reducing the time-frame of their development. Those requirements satisfying these criteria are presented along with the stand-alone modules which may be used directly by applications. The SPIMS applications operating on the CYBER 74 computer, are specialized information management systems which use System 2000 as a data base manager. Common software provides the features to support user interactions on a CRT terminal using form input and command response capabilities. These features are available as subroutines to the applications.

  10. What Types of Policies Are Required for a Constitutionally Sound, Efficient Educational System of Common Schools?

    Science.gov (United States)

    La Brecque, Richard

    This paper clarifies core concepts in a Kentucky judge's decision that the State General Assembly has failed to provide an efficient system of common schools. Connecting "efficiency" of educational systems to "equality of educational opportunity," the paper argues that the realization of a constitutionally sound, efficient…

  11. Household-level heterogeneity of water resources within common-pool resource systems

    NARCIS (Netherlands)

    McCord, Paul; Dell'angelo, Jampel; Gower, Drew; Caylor, Kelly K.; Evans, Tom

    2017-01-01

    Prior work has demonstrated the ability of common property systems to sustain institutional arrangements governing natural resources over long periods of time. Much of this work has focused on irrigation systems where upstream users agree to management arrangements that distribute water resources

  12. Common cause failure analysis of the rodded scram system of the Arkansas Nuclear One-Unit 1 Plant

    International Nuclear Information System (INIS)

    Montague, D.F.; Campbell, D.J.; Flanagan, G.F.

    1986-10-01

    This study demonstrates the use of a formal method for common cause failure analysis in a reliability analysis of the Arkansas Nuclear One - Unit 1 rodded scram system. The scram system failure of interest is loss of capability of the system to shut the reactor down when required. The results of this analysis support the ATWS program sponsored by the US Nuclear Regulatory Commission. The methods used in this analysis support the NRC's Risk Methods Integration and Evaluation Program (RMIEP)

  13. Design of visible and IR infrared dual-band common-path telescope system

    Science.gov (United States)

    Guo, YuLin; Yu, Xun; Tao, Yu; Jiang, Xu

    2018-01-01

    The use of visible and IR infrared dual-band combination can effectively improve the performance of photoelectric detection system,TV and IR system were designed with the common path by the common reflection optical system.A TV/IR infrared common-caliber and common-path system is designed,which can realize the Remote and all-day information.For the 640×512 cooled focal plane array,an infrared middle wave system was presented with a focal length of 600mm F number of 4 field of view(FOV) of 0.38°×0.43°, the system uses optical passive thermal design, has o compact structure and can meet 100% cold shield efficiency,meanwhile it meets the design requirements of lightweight and athermalization. For the 1920×1080 pixels CCD,a visible (TV) system ,which had 500mm focal length, 4F number,was completed.The final optical design along with their modulation transfer function is presented,showing excellent imaging performance in dual-band at the temperature range between -40° and 60°.

  14. Quantification of human error and common-mode failures in man-machine systems

    International Nuclear Information System (INIS)

    Lisboa, J.J.

    1988-01-01

    Quantification of human performance, particularly the determination of human error, is essential for realistic assessment of overall system performance of man-machine systems. This paper presents an analysis of human errors in nuclear power plant systems when measured against common-mode failures (CMF). Human errors evaluated are improper testing, inadequate maintenance strategy, and miscalibration. The methodology presented in the paper represents a positive contribution to power plant systems availability by identifying sources of common-mode failure when operational functions are involved. It is also applicable to other complex systems such as chemical plants, aircraft and motor industries; in fact, any large man-created, man-machine system could be included

  15. Analysis Method of Common Cause Failure on Non-safety Digital Control System

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yun Goo; Oh, Eun Gse [KHNP, Daejeon (Korea, Republic of)

    2014-08-15

    The effects of common cause failure on safety digital instrumentation and control system had been considered in defense in depth analysis with safety analysis method. However, the effects of common cause failure on non-safety digital instrumentation and control system also should be evaluated. The common cause failure can be included in credible failure on the non-safety system. In the I and C architecture of nuclear power plant, many design feature has been applied for the functional integrity of control system. One of that is segmentation. Segmentation defenses the propagation of faults in the I and C architecture. Some of effects from common cause failure also can be limited by segmentation. Therefore, in this paper there are two type of failure mode, one is failures in one control group which is segmented, and the other is failures in multiple control group because that the segmentation cannot defense all effects from common cause failure. For each type, the worst failure scenario is needed to be determined, so the analysis method has been proposed in this paper. The evaluation can be qualitative when there is sufficient justification that the effects are bounded in previous safety analysis. When it is not bounded in previous safety analysis, additional analysis should be done with conservative assumptions method of previous safety analysis or best estimation method with realistic assumptions.

  16. International Instructional Systems: Social Studies

    Science.gov (United States)

    Brant, Jacek; Chapman, Arthur; Isaacs, Tina

    2016-01-01

    This paper reports on research conducted as part of the International Instructional System Study that explored five subject areas across nine jurisdictions in six high-performing countries. The Study's overall aim was to understand what, if anything, there is in common in the curricula and assessment arrangements among the high-performing…

  17. Soil physical and microbiological attributes cultivated with the common bean under two management systems

    Directory of Open Access Journals (Sweden)

    Lorena Adriana De Gennaro

    Full Text Available Agricultural management systems can alter the physical and biological soil quality, interfering with crop development. The objective of this study was to evaluate the physical and microbiological attributes of a Red Latosol, and its relationship to the biometric parameters of the common bean (Phaseolus vulgaris, irrigated and grown under two management systems (conventional tillage and direct seeding, in Campinas in the state of São Paulo, Brazil. The experimental design was of randomised blocks, with a split-plot arrangement for the management system and soil depth, analysed during the 2006/7 and 2007/8 harvest seasons, with 4 replications. The soil physical and microbiological attributes were evaluated at depths of 0.00-0.05, 0.05-0.10, 0.10-0.20 and 0.20-0.40 m. The following were determined for the crop: density, number of pods per plant, number of beans per pod, thousand seed weight, total weight of the shoots and harvest index. Direct seeding resulted in a lower soil physical quality at a depth of 0.00-0.05 m compared to conventional tillage, while the opposite occurred at a depth of 0.05-0.10 m. The direct seeding showed higher soil biological quality, mainly indicated by the microbial biomass nitrogen, basal respiration and metabolic quotient. The biometric parameters in the bean were higher under the direct seeding compared to conventional tillage.

  18. Evaluation of a common commercial surfactant in a water recycle system

    International Nuclear Information System (INIS)

    Rector, T.; Jackson, A.; Rainwater, K.; Pickering, S.

    2002-01-01

    The fate of a common commercial surfactant was investigated in the biological reactors of a water recycle system. A NO 2 - reducing packed-bed bioreactor was employed to evaluate degradation of surfactant present in a typical greywater stream. The research was conducted to determine if an alternative commercial surfactant could be used in a biological water recycle system proposed for space travel in place of the current surfactant. The commercial soap used in the research was Pert Plus for Kids (PPK), which contains sodium laureth sulfate (SLES) as the active surfactant. Experiments included a combination of microcosm studies as well as a continuous-flow packed-bed bioreactor. The hydraulic retention time of the packed-bed bioreactor was varied through changes in flow rate to yield different steady-state values for NO 2 -N, TOC, and COD. Steady-state values will allow the determination of the bacterial kinetic parameters. Initial results suggest that the commercial surfactant may be difficult to treat in the time frame of typical biological systems. NO 2 - reduction was favorable in the packed-bed reactor, but TOC removal rates did not correspond to the NO 2 - removal. It is theorized that, due to its high K oc value (1200), SLES has an affinity to absorb to the media contained in the bed, which in turn allows for adsorption of the surfactant. Future research will include development of an isotherm model to characterize the adsorption rates and correlate them to surfactant removal. (author)

  19. Space Station Freedom electrical power system hardware commonality with the United States Polar Platform

    Science.gov (United States)

    Rieker, Lorra L.; Haraburda, Francis M.

    1989-01-01

    Information is presented on how the concept of commonality is being implemented with respect to electric power system hardware for the Space Station Freedom and the U.S. Polar Platform. Included is a historical account of the candidate common items which have the potential to serve the same power system functions on both Freedom and the Polar Platform. The Space Station program and objectives are described, focusing on the test and development responsibilities. The program definition and preliminary design phase and the design and development phase are discussed. The goal of this work is to reduce the program cost.

  20. Diagnosis of common hemoglobinopathies among South East Asian population using capillary isoelectric focusing system.

    Science.gov (United States)

    Srivorakun, H; Fucharoen, G; Sanchaisuriya, K; Fucharoen, S

    2017-02-01

    We have evaluated an automated capillary isoelectric focusing (cIEF)-based Hb analyzer in diagnosis of hemoglobinopathies commonly found among South East Asian population. Study was performed on a cohort of 665 adult Thai subjects and 13 fetal blood specimens obtained at routine thalassemia diagnostic laboratory. Hb analysis was performed using the cIEF system. Thalassemia genotypes were defined by DNA analysis. The system revealed satisfactorily within-run and between-run precision for quantitation of Hb A 2 and Hb E (CV: 0.02-0.09%). The reference ranges of Hb A 2 and Hb E were 2.6-4.0% and 25.7-33.1%, respectively. The system identified the cases of β-thalassemia and Hb E disorders correctly. Several thalassemia genotypes and Hb variants were identifiable. However, Hb Constant Spring was separated closely to Hb A 2 and Hbs Bart's and H were relatively difficult to be reported due to interfering peaks separating at the same regions. Prenatal diagnosis by fetal blood analysis was found to be accurate for Hb Bart's hydrops fetalis and Hb E-β 0 -thalassemia disease. The cIEF system could accurately diagnose β-thalassemia and Hb E carriers and demonstrate many Hb variants found in the region. The system cannot report Hb A 2 in the presence of Hb E whereas Hbs Lepore and F are comigrated. Diagnosis of α-thalassemia disease based on Hb H and Hb Bart's might be difficult. © 2016 John Wiley & Sons Ltd.

  1. MDEP Generic Common Position No DICWG-03. Common position on verification and validation throughout the life cycle of digital safety systems

    International Nuclear Information System (INIS)

    2013-01-01

    Verification and validation (V and V) is essential throughout the life cycle of nuclear power plant safety systems. This common position applies to V and V activities for digital safety systems throughout their life cycles. This encompasses both the software and hardware of such systems. The Digital Instrumentation and Controls Working Group (DICWG) has agreed that a common position on this topic is warranted given the use of Digital I and C in new reactor designs, its safety implications, and the need to develop a common understanding from the perspectives of regulatory authorities. This action follows the DICWG examination of the regulatory requirements of the participating members and of relevant industry standards and IAEA documents. The DICWG proposes a common position based on its recent experience with the new reactor application reviews and operating plant issues

  2. An analytical framework for common-pool resource–large technical system (CPR-LTS constellations

    Directory of Open Access Journals (Sweden)

    Pär Blomkvist

    2013-02-01

    Full Text Available This paper introduces an analytical framework for a special phenomenon: when a common-pool resource (CPR institution and a large technical system (LTS are connected and mutually interdependent. The CPR in this case is a node managed by its appropriators within a centrally planned and managed system; here named CPR-LTS constellations. Our framework is empirically derived from two historical investigations of CPR institutions within two LTSs, the agricultural-technical system and the road transport system of Sweden. By comparing similarities and differences it is possible to identify paths to successes and failures. To understand why one survived and the other disappeared we connect Elinor Ostrom’s theories about management of CPRs with Thomas P. Hughes’s theories about LTSs. We are proposing a framework that can bridge the gap between theories about management of CPRs and LTSs. By combining the two theories it should be possible to better understand how small-scale producers using bottom-up CPRs can be linked to top-down LTSs.We will argue that to fit within an LTS, a CPR needs alignment between different parts or components within the constellation/system and alignment with other systems and institutions in society. We propose three analytical levels to deal with the phenomenon of aligning a CPR project to an existing, large sociotechnical system:Local alignment (CPR: How are CPRs organized and managed at local sites?Sociotechnical alignment (CPR-LTS: How are CPRs connected to the sociotechnical system?Contextual alignment: How are CPR-LTS constellations aligned with neighboring institutions and systems in society?Our work indicates that for successful management of a CPR-LTS constellation it is important that the CPR be included in legislation and that government agencies support the CPR in alignment with the LTS. Legislators must recognize the CPR-part in the CPR-LTS constellation so that its institutional body is firmly established in

  3. Using Object-Orientation as a Common Basis for System Development Education

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann; Knudsen, Jørgen Lindskov

    1996-01-01

    development method where they make a number of iterations through analysis, design and implementation. To do these iterations, it is necessary with good development tools like a CASE tool that supports code generation and reverse engineering. The Mjølner BETA System is used in the various courses as a common...... areas to be taught. Besides providing a common conceptual framework, it also makes it possible to use common languages and tools that have a profound influence on the integration. Especially in the software engineering course, it has been possible to let the students experience an iterative software...... platform, but the students are also introduced to other object-oriented environments like Smalltalk, Self, Eiffel, and C++. The Mjølner BETA System that is a software development environment for object-oriented development based on the BETA programming language....

  4. Optical system design with common aperture for mid-infrared and laser composite guidance

    Science.gov (United States)

    Zhang, Xuanzhi; Yang, Zijian; Sun, Ting; Yang, Huamei; Han, Kunye; Hu, Bo

    2017-02-01

    When the field of operation of precision strike missiles is more and more complicated, autonomous seekers will soon encounter serious difficulties, especially with regard to low signature targets and complex scenarios. So the dual-mode sensors combining an imaging sensor with a semi-active laser seeker are conceived to overcome these specific problems. Here the sensors composed a dual field of view mid-infrared thermal imaging camera and a laser range finder have the common optical aperture which produced the minization of seeker construction. The common aperture optical systems for mid-infrared and laser dual-mode guildance have been developed, which could meet the passive middle infrared high-resolution imaging and the active laser high-precision indication and ranging. The optical system had good image quality, and fulfilled the performance requirement of seeker system. The design and expected performance of such a dual-mode optical system will be discussed.

  5. Defense-in-depth for common cause failure of nuclear power plant safety system software

    International Nuclear Information System (INIS)

    Tian Lu

    2012-01-01

    This paper briefly describes the development of digital I and C system in nuclear power plant, and analyses the viewpoints of NRC and other nuclear safety authorities on Software Common Cause Failure (SWCCF). In view of the SWCCF issue introduced by the digitized platform adopted in nuclear power plant safety system, this paper illustrated a diversified defence strategy for computer software and hardware. A diversified defence-in-depth solution is provided for digital safety system of nuclear power plant. Meanwhile, analysis on problems may be faced during application of nuclear safety license are analyzed, and direction of future nuclear safety I and C system development are put forward. (author)

  6. Computational Investigation of a Boundary-Layer Ingesting Propulsion System for the Common Research Model

    Science.gov (United States)

    Blumenthal, Brennan T.; Elmiligui, Alaa; Geiselhart, Karl A.; Campbell, Richard L.; Maughmer, Mark D.; Schmitz, Sven

    2016-01-01

    The present paper examines potential propulsive and aerodynamic benefits of integrating a Boundary-Layer Ingestion (BLI) propulsion system into a typical commercial aircraft using the Common Research Model (CRM) geometry and the NASA Tetrahedral Unstructured Software System (TetrUSS). The Numerical Propulsion System Simulation (NPSS) environment is used to generate engine conditions for CFD analysis. Improvements to the BLI geometry are made using the Constrained Direct Iterative Surface Curvature (CDISC) design method. Previous studies have shown reductions of up to 25% in terms of propulsive power required for cruise for other axisymmetric geometries using the BLI concept. An analysis of engine power requirements, drag, and lift coefficients using the baseline and BLI geometries coupled with the NPSS model are shown. Potential benefits of the BLI system relating to cruise propulsive power are quantified using a power balance method, and a comparison to the baseline case is made. Iterations of the BLI geometric design are shown and any improvements between subsequent BLI designs presented. Simulations are conducted for a cruise flight condition of Mach 0.85 at an altitude of 38,500 feet and an angle of attack of 2 deg for all geometries. A comparison between available wind tunnel data, previous computational results, and the original CRM model is presented for model verification purposes along with full results for BLI power savings. Results indicate a 14.4% reduction in engine power requirements at cruise for the BLI configuration over the baseline geometry. Minor shaping of the aft portion of the fuselage using CDISC has been shown to increase the benefit from Boundary-Layer Ingestion further, resulting in a 15.6% reduction in power requirements for cruise as well as a drag reduction of eighteen counts over the baseline geometry.

  7. Computational Investigation of a Boundary-Layer Ingestion Propulsion System for the Common Research Model

    Science.gov (United States)

    Blumenthal, Brennan

    2016-01-01

    This thesis will examine potential propulsive and aerodynamic benefits of integrating a boundary-layer ingestion (BLI) propulsion system with a typical commercial aircraft using the Common Research Model geometry and the NASA Tetrahedral Unstructured Software System (TetrUSS). The Numerical Propulsion System Simulation (NPSS) environment will be used to generate engine conditions for CFD analysis. Improvements to the BLI geometry will be made using the Constrained Direct Iterative Surface Curvature (CDISC) design method. Previous studies have shown reductions of up to 25% in terms of propulsive power required for cruise for other axisymmetric geometries using the BLI concept. An analysis of engine power requirements, drag, and lift coefficients using the baseline and BLI geometries coupled with the NPSS model are shown. Potential benefits of the BLI system relating to cruise propulsive power are quantified using a power balance method and a comparison to the baseline case is made. Iterations of the BLI geometric design are shown and any improvements between subsequent BLI designs presented. Simulations are conducted for a cruise flight condition of Mach 0.85 at an altitude of 38,500 feet and an angle of attack of 2deg for all geometries. A comparison between available wind tunnel data, previous computational results, and the original CRM model is presented for model verification purposes along with full results for BLI power savings. Results indicate a 14.3% reduction in engine power requirements at cruise for the BLI configuration over the baseline geometry. Minor shaping of the aft portion of the fuselage using CDISC has been shown to increase the benefit from boundary-layer ingestion further, resulting in a 15.6% reduction in power requirements for cruise as well as a drag reduction of eighteen counts over the baseline geometry.

  8. Coercion, prohibition and great expectations: The continuing failure of the Common European Asylum System

    NARCIS (Netherlands)

    den Heijer, M.; Rijpma, J.; Spijkerboer, T.

    2016-01-01

    This contribution explains the European asylum policy crisis from three structural weaknesses of the Common European Asylum System: its reliance on coercion within the EU, its unrealistic expectations of what borders can achieve and the premise of prohibition of refugee movement in its external

  9. The cardiopulmonary continuum systemic inflammation as 'common soil' of heart and lung disease

    NARCIS (Netherlands)

    Ukena, Christian; Mahfoud, Felix; Kindermann, Michael; Kindermann, Ingrid; Bals, Robert; Voors, Adriaan A.; van Veldhuisen, Dirk J.; Boehm, Michael

    2010-01-01

    Coronary artery disease (CAD), chronic heart failure (CHF) or chronic obstructive pulmonary disease (COPD) occur commonly in the presence of each other and are associated with similar systemic inflammatory reactions. Inflammation plays a central role in the pathogenesis of these diseases. C-reactive

  10. Common-cause failure analysis of McGuire Unit 2 auxiliary feedwater system

    International Nuclear Information System (INIS)

    Rasmuson, D.M.; Shepherd, J.C.; Fowler, R.D.; Summitt, R.L.; Logan, B.W.

    1982-01-01

    A powerful method for qualitative common cause failure analysis (CCFA) of nuclear power plant systems was developed by EG and G Idaho at the Idaho National Engineering Laboratory. As a cooperative project to demonstrate and evaluate the usefulness of the method, the Duke Power Company agreed to allow a CCFA of the auxiliary feedwater system (AFWS) in their McGuire Nuclear Station Unit 2. The results of the CCFA are the subject of this discussion

  11. Common DRG System - the Future of Europe? A Response to Recent Commentary

    Directory of Open Access Journals (Sweden)

    Gerli Paat-Ahi

    2015-07-01

    Full Text Available This is a short piece in response to the “Heterogeneity of European DRG systems and potentials for a common EuroDRG system”1 by Alexander Geissler, Wilm Quentin and Reinhard Busse from the EuroDRG team. We would like to thank them for taking the time to read our article and offer excellent suggestions to the diagnosis-related group (DRG systems for further development.

  12. Some basic criteria for using of accountancy common system and nuclear material control

    International Nuclear Information System (INIS)

    Marzo, M.A.; Biaggio, A.L.

    1994-01-01

    Some basic criteria used by the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials, using in the Accountancy and Control Common System of Nuclear Materials (SCCC) are presented and the control elements are described. The SCCC is a safeguard system used for all nuclear materials present in all nuclear activities executed by Brazil and Argentina. (C.G.C.). 4 refs, 1 tab

  13. Areca nut chewing and systemic inflammation : evidence of a common pathway for systemic diseases

    NARCIS (Netherlands)

    Shafique, Kashif; Mirza, Saira Saeed; Vart, Priya; Memon, Abdul Rauf; Arain, Moin Islam; Tareen, Muhammad Farooq; Haq, Zia Ul

    2012-01-01

    Background: Areca nut, the seed of fruit of an oriental palm, known as Areca catechu, is commonly chewed in many countries. Diabetes, hypertension, cardiovascular diseases, oropharyngeal and oesophageal cancers have been associated with areca nut chewing and the mechanism by which areca nut chewing

  14. Quantitative analysis of Common cause failures in systems with a high level of redundancies

    International Nuclear Information System (INIS)

    Pereira Pagan, B.; Lopez Fdez-Quevedo, C.; Gomez, F.; Cuallado, G.

    1996-01-01

    The importance of common cause failures in plants with systems featuring a high level of redundancies, and the difficulty implied by the lack of data on specific KWU design plants have been taken into account right from the beginning of the PSA. for this reason it has been necessary to analyse the different methodologies by establishing a procedure based on the documentation available, studying its applicability and solving problems arising from of the lack of information needed to make reliable statistical estimates. It was finally decided to systematically use the alpha parameter method. In case where this was not possible, the modified Beta factor method was used, and if there were no data available for the type of component considered, generic alpha values were used. this process required the definition of certain criteria to maintain coherent parameter estimates. The final result shows the impact of the number of redundancies considered in the estimated failure probability or rare. This process is valid for any size of system modelled. (Author)

  15. Overview of results and perspectives from the Shoreham major common-cause initiating events study

    International Nuclear Information System (INIS)

    Joksimovich, V.; Orvis, D.D.; Paccione, R.J.

    1986-01-01

    This study represents the continuation of a large effort by LILCO to fully understand the potential hazards posed by future operation of the Shoreham Nuclear Power Stations (SNPS). The Shoreham Probabilistic Risk Assessment, a level 3 PRA without external events, provided a characterization of the accident sequences that could leave the core in a condition in which it would be vulnerable to severe damage if further mitigating actions were not taken. It estimated the frequency and magnitude of the potential radioactivity releases associated with such sequences. The study was limited to accident sequences initiated by so called internal events to the plant including a loss of offsite power. It also characterized the public risk associated with those accident sequences. The ''Major Common-Cause Initiating Events Study'' (MCCI) for the Shoreham plant was performed to obtain insights into the plant's susceptibility to, and inherent defenses against, certain MCCIs. Major common-cause initiating events are occurrences which have the potential to initiate a plant transient or LOCA and, also, damage one or more plant systems needed to mitigate the effects of a transient or LOCA. The scope of the MCCI study included detailed analyses of seismic events and fires through the severe core damage and bounding analyses of aircraft crashes, windstorms, turbine missiles and release of hazardous materials near the plant

  16. H-Bridge Transformerless Inverter with Common Ground for Single-Phase Solar-Photovoltaic System

    DEFF Research Database (Denmark)

    Siwakoti, Yam Prasad; Blaabjerg, Frede

    2017-01-01

    This paper proposes a new single-phase H-Bridge transformerless inverter with common ground for grid-connected photovoltaic systems (hereafter it is called ‘Siwakoti-H’ inverter). The inverter works on the principle of flying capacitor and consists of only four power switches (two reverse blocking...... IGBT's (RB-IGBT) and two MOSFET's), a capacitor and a small filter at the output stage. The proposed topology share a common ground with the grid and the PV source. A Unipolar Sinusoidal Pulse-Width Modulation (SPWM) technique is used to modulate the inverter to minimize switching loss, output current...

  17. Coordinate alignment of combined measurement systems using a modified common points method

    Science.gov (United States)

    Zhao, G.; Zhang, P.; Xiao, W.

    2018-03-01

    The co-ordinate metrology has been extensively researched for its outstanding advantages in measurement range and accuracy. The alignment of different measurement systems is usually achieved by integrating local coordinates via common points before measurement. The alignment errors would accumulate and significantly reduce the global accuracy, thus need to be minimized. In this thesis, a modified common points method (MCPM) is proposed to combine different traceable system errors of the cooperating machines, and optimize the global accuracy by introducing mutual geometric constraints. The geometric constraints, obtained by measuring the common points in individual local coordinate systems, provide the possibility to reduce the local measuring uncertainty whereby enhance the global measuring certainty. A simulation system is developed in Matlab to analyze the feature of MCPM using the Monto-Carlo method. An exemplary setup is constructed to verify the feasibility and efficiency of the proposed method associated with laser tracker and indoor iGPS systems. Experimental results show that MCPM could significantly improve the alignment accuracy.

  18. The common mode failures analysis of the redundent system with dependent human error

    International Nuclear Information System (INIS)

    Kim, M.K.; Chang, S.H.

    1983-01-01

    Common mode failures (CMFs) have been a serious concern in the nuclear power plant. Thereis a broad category of the failure mechanisms that can cause common mode failures. This paper is a theoretical investigation of the CMFs on the unavailability of the redundent system. It is assumed that the total CMFs consist of the potential CMFs and the dependent human error CMFs. As the human error dependency is higher, the total CMFs are more effected by the dependent human error. If the human error dependence is lower, the system unavailability strongly depends on the potential CMFs, rather than the mechanical failure or the dependent human error. And it is shown that the total CMFs are dominant factor to the unavailability of the redundent system. (Author)

  19. Analysis approach for common cause failure on non-safety digital control system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yun Goo; Oh, Eungse [Korea Hydro and Nuclear Power Co. Ltd., Daejeon (Korea, Republic of)

    2014-05-15

    The effects of common cause failure (CCF) on safety digital instrumentation and control (I and C) system had been considered in defense in depth and diversity coping analysis with safety analysis method. For the non-safety system, single failure had been considered for safety analysis. IEEE Std. 603-1991, Clause 5.6.3.1(2), 'Isolation' states that no credible failure on the non-safety side of an isolation device shall prevent any portion of a safety system from meeting its minimum performance requirements during and following any design basis event requiring that safety function. The software CCF is one of the credible failure on the non-safety side. In advanced digital I and C system, same hardware component is used for different control system and the defect in manufacture or common external event can generate CCF. Moreover, the non-safety I and C system uses complex software for its various function and software quality assurance for the development process is less severe than safety software for the cost effective design. Therefore the potential defects in software cannot be ignored and the effect of software CCF on non-safety I and C system is needed to be evaluated. This paper proposes the general process and considerations for the analysis of CCF on non-safety I and C system.

  20. Overview of Four Functional Classification Systems Commonly Used in Cerebral Palsy

    Directory of Open Access Journals (Sweden)

    Andrea Paulson

    2017-04-01

    Full Text Available Cerebral palsy (CP is the most common physical disability in childhood. CP comprises a heterogeneous group of disorders that can result in spasticity, dystonia, muscle contractures, weakness and coordination difficulty that ultimately affects the ability to control movements. Traditionally, CP has been classified using a combination of the motor type and the topographical distribution, as well as subjective severity level. Imprecise terms such as these tell very little about what a person is able to do functionally and can impair clear communication between providers. More recently, classification systems have been created employing a simple ordinal grading system of functional performance. These systems allow a more precise discussion between providers, as well as better subject stratification for research. The goal of this review is to describe four common functional classification systems for cerebral palsy: the Gross Motor Function Classification System (GMFCS, the Manual Ability Classification System (MACS, the Communication Function Classification System (CFCS, and the Eating and Drinking Ability Classification System (EDACS. These measures are all standardized, reliable, and complementary to one another.

  1. Common data buffer system. [communication with computational equipment utilized in spacecraft operations

    Science.gov (United States)

    Byrne, F. (Inventor)

    1981-01-01

    A high speed common data buffer system is described for providing an interface and communications medium between a plurality of computers utilized in a distributed computer complex forming part of a checkout, command and control system for space vehicles and associated ground support equipment. The system includes the capability for temporarily storing data to be transferred between computers, for transferring a plurality of interrupts between computers, for monitoring and recording these transfers, and for correcting errors incurred in these transfers. Validity checks are made on each transfer and appropriate error notification is given to the computer associated with that transfer.

  2. MDEP Common Position CP-EPRWG-04. Common position on EPR containment heat removal system in accident conditions

    International Nuclear Information System (INIS)

    2015-01-01

    The importance of the integrity of the containment as a fundamental barrier to protect the people and environment against the effects of a nuclear accident is well established. In this regard, an essential objective is that the necessity for off-site counter-measures to reduce radiological consequences be limited or even eliminated. The design should provide engineering means to address those sequences which would otherwise lead to large or early releases, even in case of severe external hazards. The plant shall be designed so that it can be brought into a controlled and stable state and the containment function can be maintained, under accident conditions in which there is a significant amount of radioactive material in the containment, i.e. resulting from severe degradation of the reactor core. It is expected that due consideration to these requirements is to be given while tailoring long term loss of electrical power mitigation strategies. In order to reliably maintain the containment barrier, the regulators believe that: - safety features specifically designed for fulfilling safety functions required in core melt accidents shall be independent to the extent reasonably practicable from the Systems, Structures and Components (SSC) of the other levels of defense; - safety features specifically designed for fulfilling safety functions required in core melt accidents shall be safety classified and adequately qualified for the core melt accident environmental conditions for the time frame for which they are required to operate. In the light of the Fukushima Daiichi accident, the regulators believe that those safety features shall be designed with an adequate margin as compared to the levels of natural hazards considered for the site hazard evaluation; - the systems and components necessary for ensuring the containment function in a core melt accident shall have reliability commensurate with the function that they are required to fulfil. This may require redundancy of

  3. Procedures for treating common cause failures in safety and reliability studies: Procedural framework and examples

    International Nuclear Information System (INIS)

    Mosleh, A.; Fleming, K.N.; Parry, G.W.; Paula, H.M.; Worledge, D.H.; Rasmuson, D.M.

    1988-01-01

    This report presents a framework for the inclusion of the impact of common cause failures in risk and reliability evaluations. Common cause failures are defined as that cutset of dependent failures for which causes are not explicitly included in the logic model as basic events. The emphasis here is on providing procedures for a practical, systematic approach that can be used to perform and clearly document the analysis. The framework comprises four major stages: (1) System Logic Model Development; (2) Identification of Common Cause Component Groups; (3) Common Cause Modeling and Data Analysis; and (4) System Quantification and Interpretation of Results. The framework and the methods discussed for performing the different stages of the analysis integrate insights obtained from engineering assessments of the system and the historical evidence from multiple failure events into a systematic, reproducible, and defensible analysis. 22 figs., 34 tabs

  4. Spectral domain, common path OCT in a handheld PIC based system

    Science.gov (United States)

    Leinse, Arne; Wevers, Lennart; Marchenko, Denys; Dekker, Ronald; Heideman, René G.; Ruis, Roosje M.; Faber, Dirk J.; van Leeuwen, Ton G.; Kim, Keun Bae; Kim, Kyungmin

    2018-02-01

    Optical Coherence Tomography (OCT) has made it into the clinic in the last decade with systems based on bulk optical components. The next disruptive step will be the introduction of handheld OCT systems. Photonic Integrated Circuit (PIC) technology is the key enabler for this further miniaturization. PIC technology allows signal processing on a stable platform and the implementation of a common path interferometer in that same platform creates a robust fully integrated OCT system with a flexible fiber probe. In this work the first PIC based handheld and integrated common path based spectral domain OCT system is described and demonstrated. The spectrometer in the system is based on an Arrayed Waveguide Grating (AWG) and fully integrated with the CCD and a fiber probe into a system operating at 850 nm. The AWG on the PIC creates a 512 channel spectrometer with a resolution of 0.22 nm enabling a high speed analysis of the full A-scan. The silicon nitride based proprietary waveguide technology (TriPleXTM) enables low loss complex photonic structures from the visible (405 nm) to IR (2350 nm) range, making it a unique candidate for OCT applications. Broadband AWG operation from visible to 1700 nm has been shown in the platform and Photonic Design Kits (PDK) are available enabling custom made designs in a system level design environment. This allows a low threshold entry for designing new (OCT) designs for a broad wavelength range.

  5. Quality Assurance of Cancer Study Common Data Elements Using A Post-Coordination Approach.

    Science.gov (United States)

    Jiang, Guoqian; Solbrig, Harold R; Prud'hommeaux, Eric; Tao, Cui; Weng, Chunhua; Chute, Christopher G

    2015-01-01

    Domain-specific common data elements (CDEs) are emerging as an effective approach to standards-based clinical research data storage and retrieval. A limiting factor, however, is the lack of robust automated quality assurance (QA) tools for the CDEs in clinical study domains. The objectives of the present study are to prototype and evaluate a QA tool for the study of cancer CDEs using a post-coordination approach. The study starts by integrating the NCI caDSR CDEs and The Cancer Genome Atlas (TCGA) data dictionaries in a single Resource Description Framework (RDF) data store. We designed a compositional expression pattern based on the Data Element Concept model structure informed by ISO/IEC 11179, and developed a transformation tool that converts the pattern-based compositional expressions into the Web Ontology Language (OWL) syntax. Invoking reasoning and explanation services, we tested the system utilizing the CDEs extracted from two TCGA clinical cancer study domains. The system could automatically identify duplicate CDEs, and detect CDE modeling errors. In conclusion, compositional expressions not only enable reuse of existing ontology codes to define new domain concepts, but also provide an automated mechanism for QA of terminological annotations for CDEs.

  6. Modern methods of high-pressure fuel pump common rail power system diagnostics

    Directory of Open Access Journals (Sweden)

    Kyshchun В.

    2016-08-01

    Full Text Available We've considered high pressure fuel pumps design features and equipment for their diagnosis. It was noted that the reliability of the fuel elements Common Rail system primarily provide precision parts of the fuel equipment. As a consequence, the aim of study was comparative analysis and laborious of modern methods of the high pressure fuel pump diagnosing. In particular, the definition of a technical condition of the fuel pump was carried out using a special stand and by measuring the fuel pressure and duty cycle of the pressure regulator signal. As an object of our research we've chosen Bosch № 0445010008 fuel pump (from Mercedes Benz E320cdi in which the plunger pairs were changed alternately with different technical conditions. Preliminary fuel pump parameters were determined by hydraulic testing. Based on conducted experiments we've found out that fuel pressure measurement change method and the duty cycle of the pressure regulator signal at the starting and full load modes less laborious compared to the definition of a technical condition of the pump on the stand. The results of both methods of diagnosing confirmed identity of the fuel pumps.

  7. Serving Social Justice: The Role of the Commons in Sustainable Food Systems

    Directory of Open Access Journals (Sweden)

    Jennifer Sumner

    2011-07-01

    Full Text Available Food is a source of sustenance, a cause for celebration, an inducement to temptation, a vehicle for power, an indicator of well-being, a catalyst for change and, above all, a life good.  Along with other life goods such as potable water, clean air, adequate shelter and protective clothing, food is something we cannot live without.  The global corporate food system, however, allows 800 million to go hungry, while an even larger number of people grow obese.  Based in money-values, this food system promotes accumulation first and foremost, enriching a few while creating economic, social and environmental externalities that are destroying local economies, devastating individuals, families and communities and degrading the planet. What would a food system look like that was based in life-values, centred on the commons and anchored by social justice?  This paper will focus on the creation of sustainable food systems, beginning with the crises of the global corporate food system and then moving to the heart of sustainable food systems – the civil commons.

  8. Serving Social Justice: The Role of the Commons in Sustainable Food Systems

    Directory of Open Access Journals (Sweden)

    Jennifer Sumner

    2011-08-01

    Full Text Available

    Food is a source of sustenance, a cause for celebration, an inducement to temptation, a vehicle for power, an indicator of well-being, a catalyst for change and, above all, a life good.  Along with other life goods such as potable water, clean air, adequate shelter and protective clothing, food is something we cannot live without.  The global corporate food system, however, allows 800 million to go hungry, while an even larger number of people grow obese.  Based in money-values, this food system promotes accumulation first and foremost, enriching a few while creating economic, social and environmental externalities that are destroying local economies, devastating individuals, families and communities and degrading the planet.

    What would a food system look like that was based in life-values, centred on the commons and anchored by social justice?  This paper will focus on the creation of sustainable food systems, beginning with the crises of the global corporate food system and then moving to the heart of sustainable food systems – the civil commons.

  9. Multitask TSK fuzzy system modeling by mining intertask common hidden structure.

    Science.gov (United States)

    Jiang, Yizhang; Chung, Fu-Lai; Ishibuchi, Hisao; Deng, Zhaohong; Wang, Shitong

    2015-03-01

    The classical fuzzy system modeling methods implicitly assume data generated from a single task, which is essentially not in accordance with many practical scenarios where data can be acquired from the perspective of multiple tasks. Although one can build an individual fuzzy system model for each task, the result indeed tells us that the individual modeling approach will get poor generalization ability due to ignoring the intertask hidden correlation. In order to circumvent this shortcoming, we consider a general framework for preserving the independent information among different tasks and mining hidden correlation information among all tasks in multitask fuzzy modeling. In this framework, a low-dimensional subspace (structure) is assumed to be shared among all tasks and hence be the hidden correlation information among all tasks. Under this framework, a multitask Takagi-Sugeno-Kang (TSK) fuzzy system model called MTCS-TSK-FS (TSK-FS for multiple tasks with common hidden structure), based on the classical L2-norm TSK fuzzy system, is proposed in this paper. The proposed model can not only take advantage of independent sample information from the original space for each task, but also effectively use the intertask common hidden structure among multiple tasks to enhance the generalization performance of the built fuzzy systems. Experiments on synthetic and real-world datasets demonstrate the applicability and distinctive performance of the proposed multitask fuzzy system model in multitask regression learning scenarios.

  10. A Concept of Constructing a Common Information Space for High Tech Programs Using Information Analytical Systems

    Science.gov (United States)

    Zakharova, Alexandra A.; Kolegova, Olga A.; Nekrasova, Maria E.

    2016-04-01

    The paper deals with the issues in program management used for engineering innovative products. The existing project management tools were analyzed. The aim is to develop a decision support system that takes into account the features of program management used for high-tech products: research intensity, a high level of technical risks, unpredictable results due to the impact of various external factors, availability of several implementing agencies. The need for involving experts and using intelligent techniques for information processing is demonstrated. A conceptual model of common information space to support communication between members of the collaboration on high-tech programs has been developed. The structure and objectives of the information analysis system “Geokhod” were formulated with the purpose to implement the conceptual model of common information space in the program “Development and production of new class mining equipment - “Geokhod”.

  11. Towards an Ontology to Describe the Taxonomy of Common Modules in Learning Management Systems

    Directory of Open Access Journals (Sweden)

    Carlos E. Montenegro Marin

    2011-12-01

    Full Text Available This article have the objective a create ontology for "common modules in a Learning Management Systems", the steps for the build Ontology were: Determine the domain and scope of the ontology, Consider reusing existing ontology, Enumerate important terms in the ontology, Define the classes and the class hierarch, Define the properties of classes—slot and Define the facets of the slot, finally be explained how the ontology is composed.

  12. Study Finds Association between Biological Marker and Susceptibility to the Common Cold

    Science.gov (United States)

    ... W X Y Z Study Finds Association Between Biological Marker and Susceptibility to the Common Cold Share: © ... a cold caused by a particular rhinovirus. The biological marker identified in the study was the length ...

  13. Common mental disorders and subsequent work disability: a population-based Health 2000 Study.

    Science.gov (United States)

    Ahola, Kirsi; Virtanen, Marianna; Honkonen, Teija; Isometsä, Erkki; Aromaa, Arpo; Lönnqvist, Jouko

    2011-11-01

    Work disability due to common mental disorders has increased in Western countries during the past decade. The contribution of depressive, anxiety, and alcohol use disorders to all disability pensions at the population level is not known. Epidemiological health data from the Finnish Health 2000 Study, gathered in 2000-2001, was linked to the national register on disability pensions granted due to the ICD-10 diagnoses up to December 2007. Mental health at baseline was assessed using the Composite International Diagnostic Interview (CIDI). Sociodemographic, clinical, and work-related factors, health behaviors, and treatment setting were used as covariates in the logistic regression analyses among the 3164 participants aged 30-58 years. Anxiety, depressive, and comorbid common mental disorders predicted disability pension when adjusted for sex and age. In the fully adjusted multivariate model, comorbid common mental disorders, as well as physical illnesses, age over 45 years, short education, high job strain, and previous long-term sickness absence predicted disability pension. The study population included persons aged 30 or over. Sub groups according to mental disorders were quite small which may have diminished statistical power in some sub groups. Baseline predictors were measured only once and the length of exposure could not be determined. The systems regarding financial compensation to employees differ between countries. Comorbid mental disorders pose a high risk for disability pension. Other independent predictors of work disability include socio-demographic, clinical, work-related, and treatment factors, but not health behavior. More attention should be paid to work-related factors in order to prevent chronic work disability. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China.

    Science.gov (United States)

    Xia, Liangyu; Chen, Ming; Liu, Min; Tao, Zhihua; Li, Shijun; Wang, Liang; Cheng, Xinqi; Qin, Xuzhen; Han, Jianhua; Li, Pengchang; Hou, Li'an; Yu, Songlin; Ichihara, Kiyoshi; Qiu, Ling

    2016-03-01

    A nationwide multicenter study was conducted in the China to explore sources of variation of reference values and establish reference intervals for 28 common biochemical analytes, as a part of the International Federation of Clinical Chemistry and Laboratory Medicine, Committee on Reference Intervals and Decision Limits (IFCC/C-RIDL) global study on reference values. A total of 3148 apparently healthy volunteers were recruited in 6 cities covering a wide area in China. Blood samples were tested in 2 central laboratories using Beckman Coulter AU5800 chemistry analyzers. Certified reference materials and value-assigned serum panel were used for standardization of test results. Multiple regression analysis was performed to explore sources of variation. Need for partition of reference intervals was evaluated based on 3-level nested ANOVA. After secondary exclusion using the latent abnormal values exclusion method, reference intervals were derived by a parametric method using the modified Box-Cox formula. Test results of 20 analytes were made traceable to reference measurement procedures. By the ANOVA, significant sex-related and age-related differences were observed in 12 and 12 analytes, respectively. A small regional difference was observed in the results for albumin, glucose, and sodium. Multiple regression analysis revealed BMI-related changes in results of 9 analytes for man and 6 for woman. Reference intervals of 28 analytes were computed with 17 analytes partitioned by sex and/or age. In conclusion, reference intervals of 28 common chemistry analytes applicable to Chinese Han population were established by use of the latest methodology. Reference intervals of 20 analytes traceable to reference measurement procedures can be used as common reference intervals, whereas others can be used as the assay system-specific reference intervals in China.

  15. A Transparent Translation from Legacy System Model into Common Information Model: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Fei [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Simpson, Jeffrey [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Zhang, Yingchen [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2018-04-27

    Advance in smart grid is forcing utilities towards better monitoring, control and analysis of distribution systems, and requires extensive cyber-based intelligent systems and applications to realize various functionalities. The ability of systems, or components within systems, to interact and exchange services or information with each other is the key to the success of smart grid technologies, and it requires efficient information exchanging and data sharing infrastructure. The Common Information Model (CIM) is a standard that allows different applications to exchange information about an electrical system, and it has become a widely accepted solution for information exchange among different platforms and applications. However, most existing legacy systems are not developed using CIM, but using their own languages. Integrating such legacy systems is a challenge for utilities, and the appropriate utilization of the integrated legacy systems is even more intricate. Thus, this paper has developed an approach and open-source tool in order to translate legacy system models into CIM format. The developed tool is tested for a commercial distribution management system and simulation results have proved its effectiveness.

  16. Uncertainties and quantification of common cause failure rates and probabilities for system analyses

    International Nuclear Information System (INIS)

    Vaurio, Jussi K.

    2005-01-01

    Simultaneous failures of multiple components due to common causes at random times are modelled by constant multiple-failure rates. A procedure is described for quantification of common cause failure (CCF) basic event probabilities for system models using plant-specific and multiple-plant failure-event data. Methodology is presented for estimating CCF-rates from event data contaminated with assessment uncertainties. Generalised impact vectors determine the moments for the rates of individual systems or plants. These moments determine the effective numbers of events and observation times to be input to a Bayesian formalism to obtain plant-specific posterior CCF-rates. The rates are used to determine plant-specific common cause event probabilities for the basic events of explicit fault tree models depending on test intervals, test schedules and repair policies. Three methods are presented to determine these probabilities such that the correct time-average system unavailability can be obtained with single fault tree quantification. Recommended numerical values are given and examples illustrate different aspects of the methodology

  17. Jasmonic acid and salicylic acid activate a common defense system in rice.

    Science.gov (United States)

    Tamaoki, Daisuke; Seo, Shigemi; Yamada, Shoko; Kano, Akihito; Miyamoto, Ayumi; Shishido, Hodaka; Miyoshi, Seika; Taniguchi, Shiduku; Akimitsu, Kazuya; Gomi, Kenji

    2013-06-01

    Jasmonic acid (JA) and salicylic acid (SA) play important roles in plant defense systems. JA and SA signaling pathways interact antagonistically in dicotyledonous plants, but, the status of crosstalk between JA and SA signaling is unknown in monocots. Our rice microarray analysis showed that more than half of the genes upregulated by the SA analog BTH are also upregulated by JA, suggesting that a major portion of the SA-upregulated genes are regulated by JA-dependent signaling in rice. A common defense system that is activated by both JA and SA is thus proposed which plays an important role in pathogen defense responses in rice.

  18. Speaking with a Commonality Language: A Lexicon for System and Component Development

    Science.gov (United States)

    2007-01-01

    Abdullahil Azeem, “Impact of Commonality and Flexibility on Manufacturing Performance: A Simulation Study,” International Journal of Production Economics , Vols...Cycle Costs of Products,” International Journal of Production Economics , Vols. 60–61, April 1999, pp. 109–116. Robertson, David, and Karl Ulrich

  19. Revisiting Traveling Books: Early Literacy, Social Studies, and the Common Core

    Science.gov (United States)

    Swain, Holly Hilboldt; Coleman, Julianne

    2015-01-01

    With the development and institution of the Common Core Standards, teachers must be prepared to integrate content areas such as social studies within the language arts curriculum. Teachers following the suggestions of the Common Core Standards should develop practical and meaningful strategies within their classrooms that encourage and support…

  20. Mission needs and system commonality for space nuclear power and propulsion

    International Nuclear Information System (INIS)

    Buden, D.; Zuppero, A.; Redd, L.

    1993-01-01

    Nuclear power enables or significantly enhances a variety of space missions whether near-Earth, or for solar system exploration, lunar-Mars exploration and recovery of near-Earth resources. Performance optimizations for individual missions leads to a large number of power and propulsion systems to be developed. However, the realities of the budget and schedules indicates that the number of nuclear systems that will be developed are limited. One needs to seek the ''minimum requirements'' to do a job rather than the last ounce of performance, and areas of commonality. To develop a minimum number of systems to meet the overall DoD, NASA, and commercial needs, the broad spectrum of requirements has been examined along with cost drivers

  1. Interactive visual steering--rapid visual prototyping of a common rail injection system.

    Science.gov (United States)

    Matković, Kresimir; Gracanin, Denis; Jelović, Mario; Hauser, Helwig

    2008-01-01

    Interactive steering with visualization has been a common goal of the visualization research community for twenty years, but it is rarely ever realized in practice. In this paper we describe a successful realization of a tightly coupled steering loop, integrating new simulation technology and interactive visual analysis in a prototyping environment for automotive industry system design. Due to increasing pressure on car manufacturers to meet new emission regulations, to improve efficiency, and to reduce noise, both simulation and visualization are pushed to their limits. Automotive system components, such as the powertrain system or the injection system have an increasing number of parameters, and new design approaches are required. It is no longer possible to optimize such a system solely based on experience or forward optimization. By coupling interactive visualization with the simulation back-end (computational steering), it is now possible to quickly prototype a new system, starting from a non-optimized initial prototype and the corresponding simulation model. The prototyping continues through the refinement of the simulation model, of the simulation parameters and through trial-and-error attempts to an optimized solution. The ability to early see the first results from a multidimensional simulation space--thousands of simulations are run for a multidimensional variety of input parameters--and to quickly go back into the simulation and request more runs in particular parameter regions of interest significantly improves the prototyping process and provides a deeper understanding of the system behavior. The excellent results which we achieved for the common rail injection system strongly suggest that our approach has a great potential of being generalized to other, similar scenarios.

  2. A Systems Approach to Developing an Affordable Space Ground Transportation Architecture using a Commonality Approach

    Science.gov (United States)

    Garcia, Jerry L.; McCleskey, Carey M.; Bollo, Timothy R.; Rhodes, Russel E.; Robinson, John W.

    2012-01-01

    This paper presents a structured approach for achieving a compatible Ground System (GS) and Flight System (FS) architecture that is affordable, productive and sustainable. This paper is an extension of the paper titled "Approach to an Affordable and Productive Space Transportation System" by McCleskey et al. This paper integrates systems engineering concepts and operationally efficient propulsion system concepts into a structured framework for achieving GS and FS compatibility in the mid-term and long-term time frames. It also presents a functional and quantitative relationship for assessing system compatibility called the Architecture Complexity Index (ACI). This paper: (1) focuses on systems engineering fundamentals as it applies to improving GS and FS compatibility; (2) establishes mid-term and long-term spaceport goals; (3) presents an overview of transitioning a spaceport to an airport model; (4) establishes a framework for defining a ground system architecture; (5) presents the ACI concept; (6) demonstrates the approach by presenting a comparison of different GS architectures; and (7) presents a discussion on the benefits of using this approach with a focus on commonality.

  3. Risk factors for common mental disorders in women. Population-based longitudinal study.

    Science.gov (United States)

    Patel, Vikram; Kirkwood, Betty R; Pednekar, Sulochana; Weiss, Helen; Mabey, David

    2006-12-01

    The determinants of common mental disorders in women have not been described in longitudinal studies from a low-income country. Population-based cohort study of 2494 women aged 18 to 50 years, in India. The Revised Clinical Interview Schedule was used for the detection of common mental disorders. There were 39 incident cases of common mental disorder in 2166 participants eligible for analysis (12-month rate 1.8%, 95% CI 1.3-2.4%). The following baseline factors were independently associated with the risk for common mental disorder: poverty (low income and having difficulty making ends meet); being married as compared with being single; use of tobacco; experiencing abnormal vaginal discharge; reporting a chronic physical illness; and having higher psychological symptom scores at baseline. Programmes to reduce the burden of common mental disorder in women should target poorer women, women with chronic physical illness and who have gynaecological symptoms, and women who use tobacco.

  4. A Common Definition of the System Operators' Core Activities[Electric Power Transmission System Operator

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-02-15

    In this report a common definition of the system operator's core activities in the Nordic countries is identified and also a list of non-core activities is introduced. As a starting point the common tasks for system responsibility as identified by Nordel has been used for the work. The term TSO (Transmission System Operator) is employed as a common denominator in the report. It is found out that the TSOs carry out common core activities in the roles as a transmission operator, a system operator and a balance settlement responsible. The core activities for the TSO as a transmission network operator are: Maintain the adequate transmission system in the long run and network development plan on the national as well as on the Nordic level using sophisticated analysis and planning methods and tools. Plan the transmission network on the national as well as on the Nordic level utilising new investments, renewal and maintenance of existing network components so that the network is secure to operate and adequate transmission capacity is guaranteed. Aim at timely network expansions using enhanced information exchange between the Nordic TSOs, and on the national level between the TSO and distribution and regional network operators, large consumers and large producers. Secure the technical compatibility with networks across the border and within a country by establishing connection requirements on the national level and ensuring that the national requirements are compatible across the Nordic power system. The core activities for the TSO as a system operator are: Define common technical requirements for the secure system operation using common planning, operation, connection and data exchange procedures. Secure the system operation with the operational planning for the following year by using information exchange between TSOs enabling the TSOs to make the best possible forecast of the global grid situation in order to assess the flows in their network and the available

  5. Maximizing commonality between military and general aviation fly-by-light helicopter system designs

    Science.gov (United States)

    Enns, Russell; Mossman, David C.

    1995-05-01

    In the face of shrinking defense budgets, survival of the United States rotorcraft industry is becoming increasingly dependent on increased sales in a highly competitive civil helicopter market. As a result, only the most competitive rotorcraft manufacturers are likely to survive. A key ingredient in improving our competitive position is the ability to produce more versatile, high performance, high quality, and low cost of ownership helicopters. Fiber optic technology offers a path of achieving these objectives. Also, adopting common components and architectures for different helicopter models (while maintaining each models' uniqueness) will further decrease design and production costs. Funds saved (or generated) by exploiting this commonality can be applied to R&D used to further improve the product. In this paper, we define a fiber optics based avionics architecture which provides the pilot a fly-by-light / digital flight control system which can be implemented in both civilian and military helicopters. We then discuss the advantages of such an architecture.

  6. Diagnosis and treatment of common infectious diseases in severely ill sub-Saharan African patients : Studies from a hospital floor

    NARCIS (Netherlands)

    Bos, J.C.

    2017-01-01

    This thesis illustrates that important aspects of diagnosis and treatment of common infectious diseases in a hospital setting in Mozambique are inadequate. The inadequacies found in our studies are likely to be explained by a combination of patient population factors and health care system

  7. Managing common resources in local and global systems. Applying theory across scales

    Energy Technology Data Exchange (ETDEWEB)

    Karlsson, Sylvia [ed.

    1997-12-31

    The main point brought forward in this publication is the productiveness of applying theoretical elements, developed within common property resource (CPR) literature, to a broader field of cases on different scales. The common framework for the contributions is a series of seminars held at the Department of Water and Environmental Studies in the spring of 1996, covering expanding work during the last decade on common property resource (CPR) management. It is obvious that there were a broad range of definitions of the concept CPR in the literature. The common pool/property resource concepts are both used, often depending on the resource studied, and authors in this volume have used both terms accordingly. Certain points are raised from empirical cases presented in this volume that are partly missing or not thoroughly stressed in other work in the area of CPR management and which crystallized much clearer when contrasting the situation for cases from different scales. Separate abstracts have been performed for five of the seven contributions

  8. Managing common resources in local and global systems. Applying theory across scales

    Energy Technology Data Exchange (ETDEWEB)

    Karlsson, Sylvia [ed.

    1998-12-31

    The main point brought forward in this publication is the productiveness of applying theoretical elements, developed within common property resource (CPR) literature, to a broader field of cases on different scales. The common framework for the contributions is a series of seminars held at the Department of Water and Environmental Studies in the spring of 1996, covering expanding work during the last decade on common property resource (CPR) management. It is obvious that there were a broad range of definitions of the concept CPR in the literature. The common pool/property resource concepts are both used, often depending on the resource studied, and authors in this volume have used both terms accordingly. Certain points are raised from empirical cases presented in this volume that are partly missing or not thoroughly stressed in other work in the area of CPR management and which crystallized much clearer when contrasting the situation for cases from different scales. Separate abstracts have been performed for five of the seven contributions

  9. Septic Systems Case Studies

    Science.gov (United States)

    A collection of septic systems case studies to help community planners, elected officials, health department staff, state officials, and interested citizens explore alternatives for managing their decentralized wastewater treatment systems.

  10. Design Guide for Earth System Science Education: Common Student Learning Objectives and Special Pedagogical Approaches

    Science.gov (United States)

    Baker, D.

    2006-12-01

    As part of the NASA-supported undergraduate Earth System Science Education (ESSE) program, fifty-seven institutions have developed and implemented a wide range of Earth system science (ESS) courses, pedagogies, and evaluation tools. The Teaching, Learning, and Evaluation section of USRA's online ESSE Design Guide showcases these ESS learning environments. This Design Guide section also provides resources for faculty who wish to develop ESS courses. It addresses important course design issues including prior student knowledge and interests, student learning objectives, learning resources, pedagogical approaches, and assessments tied to student learning objectives. The ESSE Design Guide provides links to over 130 ESS course syllabi at introductory, senior, and graduate levels. ESS courses over the past 15 years exhibit common student learning objectives and unique pedagogical approaches. From analysis of ESS course syllabi, seven common student learning objectives emerged: 1) demonstrate systems thinking, 2) develop an ESS knowledge base, 3) apply ESS to the human dimension, 4) expand and apply analytical skills, 5) improve critical thinking skills, 6) build professional/career skills, and 7) acquire an enjoyment and appreciation for science. To meet these objectives, ESSE often requires different ways of teaching than in traditional scientific disciplines. This presentation will highlight some especially successful pedagogical approaches for creating positive and engaging ESS learning environments.

  11. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities

    Science.gov (United States)

    Hebert, Phillip W., Sr.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Hughes, Mark S.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition systems (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis development and deployment.

  12. A Common Criteria-Based Team Project for High Assurance Secure Systems

    Science.gov (United States)

    2005-01-01

    experience in the FHM, full system documentation, and plenty of time. The students had little experience and little time. The MINIX operating... MINIX is a very appropriate target for student enhancements. Since the principle objective of Secure Systems is to teach the concepts of...to construct a system when one of the developmental threats is subversion. Because students were studying MINIX in a prerequisite operating systems

  13. The dual impact of ecology and management on social incentives in marine common-pool resource systems.

    Science.gov (United States)

    Klein, E S; Barbier, M R; Watson, J R

    2017-08-01

    Understanding how and when cooperative human behaviour forms in common-pool resource systems is critical to illuminating social-ecological systems and designing governance institutions that promote sustainable resource use. Before assessing the full complexity of social dynamics, it is essential to understand, concretely and mechanistically, how resource dynamics and human actions interact to create incentives and pay-offs for social behaviours. Here, we investigated how such incentives for information sharing are affected by spatial dynamics and management in a common-pool resource system. Using interviews with fishermen to inform an agent-based model, we reveal generic mechanisms through which, for a given ecological setting characterized by the spatial dynamics of the resource, the two 'human factors' of information sharing and management may heterogeneously impact various members of a group for whom theory would otherwise predict the same strategy. When users can deplete the resource, these interactions are further affected by the management approach. Finally, we discuss the implications of alternative motivations, such as equity among fishermen and consistency of the fleet's output. Our results indicate that resource spatial dynamics, form of management and level of depletion can interact to alter the sociality of people in common-pool resource systems, providing necessary insight for future study of strategic decision processes.

  14. Effect of Common Faults on the Performance of Different Types of Vapor Compression Systems.

    Science.gov (United States)

    Du, Zhimin; Domanski, Piotr A; Payne, W Vance

    2016-04-05

    The effect of faults on the cooling capacity, coefficient of performance, and sensible heat ratio, was analyzed and compared for five split and rooftop systems, which use different types of expansion devices, compressors and refrigerants. The study applied multivariable polynomial and normalized performance models, which were developed for the studied systems for both fault-free and faulty conditions based on measurements obtained in a laboratory under controlled conditions. The analysis indicated differences in responses and trends between the studied systems, which underscores the challenge to devise a universal FDD algorithm for all vapor compression systems and the difficulty to develop a methodology for rating the performance of different FDD algorithms.

  15. Space station common module power system network topology and hardware development

    Science.gov (United States)

    Landis, D. M.

    1985-01-01

    Candidate power system newtork topologies for the space station common module are defined and developed and the necessary hardware for test and evaluation is provided. Martin Marietta's approach to performing the proposed program is presented. Performance of the tasks described will assure systematic development and evaluation of program results, and will provide the necessary management tools, visibility, and control techniques for performance assessment. The plan is submitted in accordance with the data requirements given and includes a comprehensive task logic flow diagram, time phased manpower requirements, a program milestone schedule, and detailed descriptions of each program task.

  16. Experimental investigations of a single cylinder genset engine with common rail fuel injection system

    Directory of Open Access Journals (Sweden)

    Gupta Paras

    2014-01-01

    Full Text Available Performance and emissions characteristics of compression ignition (CI engines are strongly dependent on quality of fuel injection. In an attempt to improve engine combustion, engine performance and reduce the exhaust emissions from a single cylinder constant speed genset engine, a common rail direct injection (CRDI fuel injection system was deployed and its injection timings were optimized. Results showed that 34°CA BTDC start of injection (SOI timings result in lowest brake specific fuel consumption (BSFC and smoke opacity. Advanced injection timings showed higher cylinder peak pressure, pressure rise rate, and heat release rate due to relatively longer ignition delay experienced.

  17. Common features of electrochemical kinetics of the lithium electrode in different electrolyte systems

    International Nuclear Information System (INIS)

    Churikov, A.V.; L'vov, A.L.; Gamayunova, I.M.; Shirokov, A.V.

    1999-01-01

    Electrochemical behaviour of Li-electrode in LiAlCl 4 solutions in thienyl chloride and LiBF 4 solutions in γ-butyrolactone is studied as well as Li-electrode with Li 2 CO 3 protected film in LiClO 4 solution in mixed solvent (propylene carbonate and dimethoxyethane). Common regularities of Li-electrode electrochemical kinetic are discussed. Methods of electrode impedance spectroscopy and pulse voltametry are used for investigations

  18. Simultaneous phase-shifting interferometry study based on the common-path Fizeau interferometer

    Science.gov (United States)

    Liu, Feng-wei; Wu, Yong-qian

    2014-09-01

    A simultaneous phase-shifting interferometry(SPSI) based on the common-path Fizeau interferometer has been discussed.In this system,two orthogonal polarized beams, using as the reference beam and test beam ,are detached by a particular Wollaston prism at a very small angle,then four equal sub-beams are achieved by a combination of three non-polarizing beam splitters(NPBS),and the phase shifts are introduced by four polarizers whose polarization azimuths are 0°, 45°, 90°, 135° with the horizontal direction respectively,the four phase shift interferograms are collected simultaneously by controlling the CCDs working at the same time .The SPSI principle is studied at first,then is the error analysis, finally we emulate the process of surface recovery by four steps phase shifts algorithm,the results indicate that, to ensure the feasibility of the SPSI system, we have to control the polarization azimuth error of the polarizer in +/- 0.5°.

  19. Common marmoset (Callithrix jacchus) as a primate model for behavioral neuroscience studies.

    Science.gov (United States)

    Prins, Noeline W; Pohlmeyer, Eric A; Debnath, Shubham; Mylavarapu, Ramanamurthy; Geng, Shijia; Sanchez, Justin C; Rothen, Daniel; Prasad, Abhishek

    2017-06-01

    The common marmoset (Callithrix jacchus) has been proposed as a suitable bridge between rodents and larger primates. They have been used in several types of research including auditory, vocal, visual, pharmacological and genetics studies. However, marmosets have not been used as much for behavioral studies. Here we present data from training 12 adult marmosets for behavioral neuroscience studies. We discuss the husbandry, food preferences, handling, acclimation to laboratory environments and neurosurgical techniques. In this paper, we also present a custom built "scoop" and a monkey chair suitable for training of these animals. The animals were trained for three tasks: 4 target center-out reaching task, reaching tasks that involved controlling robot actions, and touch screen task. All animals learned the center-out reaching task within 1-2 weeks whereas learning reaching tasks controlling robot actions task took several months of behavioral training where the monkeys learned to associate robot actions with food rewards. We propose the marmoset as a novel model for behavioral neuroscience research as an alternate for larger primate models. This is due to the ease of handling, quick reproduction, available neuroanatomy, sensorimotor system similar to larger primates and humans, and a lissencephalic brain that can enable implantation of microelectrode arrays relatively easier at various cortical locations compared to larger primates. All animals were able to learn behavioral tasks well and we present the marmosets as an alternate model for simple behavioral neuroscience tasks. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Study of ecologo-biological reactions of common flax to finely dispersed metallurgical wastes

    Science.gov (United States)

    Zakharova, O.; Gusev, A.; Skripnikova, E.; Skripnikova, M.; Krutyakov, Yu; Kudrinsky, A.; Mikhailov, I.; Senatova, S.; Chuprunov, C.; Kuznetsov, D.

    2015-11-01

    Study was carried out on the influence of metallurgic industrial sludge on morphometric and biochemical indicators as well as productivity of common flax under laboratory and field conditions. In laboratory settings negative influence on seed germinating ability and positive influence on sprouts biomass production in water medium were observed. In sand medium suppression of biological productivity under the influence of sludge together with photosynthetic system II (FS II) activity stimulation were registered. Biochemical study showed peroxidase activity decrease in laboratory, while activity of polyphenol oxidase, superoxide dismutase and catalase were given a mild boost under the influence of sludge. In the field trial, positive influence of sludge on flax photosynthetic apparatus was shown. Positive influence of sludge on vegetation and yield indicators was observed. The analysis of heavy metals content showed excess over maximum allowable concentration (MAC) of copper and zinc in control plants, it may point to the background soil pollution. In the plants from the trial groups receiving 0.5 and 2 ton/ha heavy metals content below the control values was registered. Application of 4 ton/ha led to the maximum content of copper and zinc in the plants among the trial groups. The analysis of soils from the test plots indicated no excess over maximum allowable concentrations of heavy metals. Thus, further study of possibilities of using metallurgic industrial sludge as a soil stimulator in flax cultivation at the application rate of 0.5 t/ha seems promising.

  1. EVALUATION OF VIBRATION LOAD ON COMMON RAIL FUEL SYSTEM COMPONENTS FOR DIESEL ENGINE

    Directory of Open Access Journals (Sweden)

    G. M. Kuharonak

    2014-01-01

    Full Text Available The objective of the paper is to develop a program, a methodology and execute vibration load tests of Common Rail fuel system components for a diesel engine. The paper contains an analysis of parameters that characterize vibration activity of research object and determine its applicability as a part of the specific mechanical system. A tests program has been developed that includes measurements of general peak values of vibration acceleration in the fuel system components, transformation of the obtained data while taking into account the fact that peak vibration acceleration values depend on crank-shaft rotation frequency and spectrum of vibration frequency, comparison of these dependences with the threshold limit values obtained in the process of component tests with the help of vibration shaker. The investigations have been carried out in one of the most stressed elements of the Common Rail fuel system that is a RDS 4.2-pressure sensor in a fuel accumulator manufactured by Robert Bosch GmbH and mounted on the MMZ D245.7E4-engines.According to the test methodology measurements have been performed on an engine test bench at all fullload engine curves. Vibration measurements have resulted in time history of the peak vibration acceleration values in three directions from every accelerometer and crank-shaft rotation frequency.It has been proposed to increase a diameter of mounting spacers of the fuel accumulator and install a damping clamp on high pressure tubes from a high pressure fuel pump to the fuel accumulator that permits to reduce a maximum peak vibration acceleration value on the pressure sensor in the fuel accumulator by 400 m/s2 and ensure its application in the given engine.

  2. MDEP Common Position No DICWG08. Common position on the impact of cyber security features on digital I and C safety systems

    International Nuclear Information System (INIS)

    2012-01-01

    Cyber security measures are generally implemented at nuclear facilities to protect against cyber-attacks that may compromise safety. The implementation of such cyber security measures may vary based on site specific requirements and each country's regulatory frameworks. Safety measures and cyber security measures for a nuclear power plant should be designed and implemented so that they do not compromise one another. This common position is intended to only apply to systems classified to the highest level of safety. The Digital Instrumentation and Controls Working Group (DICWG) has agreed that a common position on this topic is warranted given the increase of use of Digital I and C in new reactor designs, its safety implications, and the need to develop a common understanding from the perspectives of regulatory authorities. This action follows the DICWG examination of the regulatory requirements of the participating members and of relevant industry standards and IAEA documents. The DICWG proposes a common position based on its recent experience with the new reactor application reviews and operating plant issues

  3. Progress on HELIAS systems studies

    Energy Technology Data Exchange (ETDEWEB)

    Warmer, Felix; Beidler, Craig D.; Dinklage, Andreas; Feng, Yuehe; Geiger, Joachim; Schauer, Felix; Turkin, Yuriy; Wolf, Robert; Xanthopoulos, Pavlos [Max-Planck-Institut fuer Plasmaphysik, D-17491 Greifswald (Germany); Kemp, Richard; Knight, Peter; Ward, David [Culham Centre for Fusion Energy, Abingdon, Oxfordshire, OX14 3DB (United Kingdom)

    2015-05-01

    In order to study and design next-step fusion devices such as DEMO, comprehensive systems codes are commonly employed. For the HELIAS-line, stellarator-specific models have been developed, implemented, and verified within the systems code PROCESS. This systems code ansatz is complemented by self-consistent modeling of plasma scenarios employing a predictive 1-D neoclassical transport code which has been augmented with a model for the edge anomalous transport based on 3-D ITG turbulence simulations. This approach is investigated to ultimately allow one to conduct stellarator system studies, develop design points of HELIAS burning plasma devices, and to facilitate a direct comparison between tokamak and stellarator DEMO and power plant designs. The work reports on the progress towards these goals.

  4. Studies on common illnesses and medical care utilization patterns of adolescents in Hong Kong.

    Science.gov (United States)

    Lau, J T; Yu, A; Cheung, J C; Leung, S S

    2000-12-01

    To estimate the prevalences of common illnesses in Hong Kong adolescents, the sociodemographic and selected risk factors associated with these illnesses, and their health care utilization behavior and attitudes. A cross-sectional questionnaire survey of 3355 participating secondary school students (response rate = 98%). Self-reported 3-month prevalences were obtained for cough/cold/influenza (55.2%), digestive disorders (34.6%), accidental injuries (29.5%), headache/dizziness (23.6%), chronic anxiety/insomnia (20.1%), skin problems (9.5%), asthma (3.8%), liver disease (1.3%), and menstrual pain (13.8% of female students). Self-perceived poor health, smoking, and alcohol consumption were associated with many of these illnesses. Treatment choice depended on the illness suffered (e.g., most students with respiratory problems consulted medical practitioners, whereas most with chronic anxiety/insomnia did not). Many students lacked trust in their doctors, doctor-shopped, relied heavily on self-medication, did not comply with prescribed treatments, would not seek help about medical problems, felt they had insufficient access to health information, and wanted confidential health care. This study examined for the first time the common illnesses and health care utilization patterns of Hong Kong adolescents. Students with chronic anxiety/insomnia were much less likely to seek care, indicating a need for better education on mental health. Efforts to prevent smoking and alcohol consumption among adolescents need to be strengthened. The students' attitudes, poor compliance and help-seeking behaviors suggest suboptimal use of the health care system. Our findings are useful for international comparisons by medical practitioners, health care managers, and researchers.

  5. Quality control of software in dissimilar systems using a common clinical data base

    International Nuclear Information System (INIS)

    Erickson, J.J.; Price, R.R.; Touya, J.J.; Kronenberg, M.W.; Pederson, R.; Rollo, F.D.

    1980-01-01

    For a long time there has been widespread interest in the quality control of diagnostic instrumentation. The increasing dependence on computational systems for clinical results makes it imperative that methods for quality control of diagnostic software be developed. This paper proposes a method based on the use of a collection of patient studies for which the results have been corroborated by independent methods. The data set will be distributed in a format requiring no special handling by the system being tested and will appear identical to studies actually collected by the host system. An example of the use of a preliminary version of the data set for comparison of two systems is shown. The comparison shows that analyses performed on the two systems agree very well and can be reliably compared for follow-up studies of a patient

  6. Finding an acceleration function for calculating the reliability of redundant systems - Application to common mode failures

    International Nuclear Information System (INIS)

    Gonnot, R.

    1975-01-01

    While it may be reasonable to assume that the reliability of a system - the design of which is perfectly known - can be evaluated, it seems less easy to be sure that overall reliability is correctly estimated in the case of multiple redundancies arranged in sequence. Framatome is trying to develop a method of evaluating overall reliability correctly for its installations. For example, the protection systems in its power stations considered as a whole are such that several scram signals may be relayed in sequence when an incident occurs. These signals all involve the same components for a given type of action, but the components themselves are in fact subject to different stresses and constraints, which tend to reduce their reliability. Whatever the sequence in which these signals are transmitted (in a fast-developing accident, for example), it is possible to evaluate the actual reliability of a given system (or component) for different constraints, as the latter are generally obtained via the transient codes. By applying the so-called ''equal probability'' hypothesis one can estimate a reliability acceleration function taking into account the constraints imposed. This function is linear for the principal failure probability distribution laws. By generalizing such a method one can: (1) Perform failure calculations for redundant systems (or components) in a more general way than is possible with event trees, since one of the main parameters is the constraint exercised on that system (or component); (2) Determine failure rates of components on the basis of accelerated tests (up to complete failure of the component) which are quicker than the normal long-term tests (statistical results of operation); (3) Evaluate the multiplication factor for the reliability of a system or component in the case of common mode failures. The author presents the mathematical tools required for such a method and described their application in the cases mentioned above

  7. Workplace bullying and common mental disorders: a follow-up study.

    Science.gov (United States)

    Lahelma, Eero; Lallukka, Tea; Laaksonen, Mikko; Saastamoinen, Peppiina; Rahkonen, Ossi

    2012-06-01

    Workplace bullying has been associated with mental health, but longitudinal studies confirming the association are lacking. This study examined the associations of workplace bullying with subsequent common mental disorders 5-7 years later, taking account of baseline common mental disorders and several covariates. Baseline questionnaire survey data were collected in 2000-2002 among municipal employees, aged 40-60 years (n=8960; 80% women; response rate 67%). Follow-up data were collected in 2007 (response rate 83%). The final data amounted to 6830 respondents. Workplace bullying was measured at baseline using an instructed question about being bullied currently, previously or never. Common mental disorders were measured at baseline and at follow-up using the 12-item version of the General Health Questionnaire. Those scoring 3-12 were classified as having common mental disorders. Covariates included bullying in childhood, occupational and employment position, work stress, obesity and limiting longstanding illness. Logistic regression analysis was used. After adjusting for age, being currently bullied at baseline was associated with common mental disorders at follow-up among women (OR 2.34, CI 1.81 to 3.02) and men (OR 3.64, CI 2.13 to 6.24). The association for the previously bullied was weaker. Adjusting for baseline common mental disorders, the association attenuated but remained. Adjusting for further covariates did not substantially alter the studied association. CONCLUSION The study confirms that workplace bullying is likely to contribute to subsequent common mental disorders. Measures against bullying are needed at workplaces to prevent mental disorders.

  8. Symptoms Of Common Mental Disorders In Professional Rugby: An International Observational Descriptive Study.

    Science.gov (United States)

    Gouttebarge, Vincent; Hopley, Phil; Kerkhoffs, Gino; Verhagen, Evert; Viljoen, Wayne; Wylleman, Paul; Lambert, Mike I

    2017-10-01

    The aim of the study was to determine the prevalence of symptoms of common mental disorders among professional rugby players across countries. A cross-sectional analysis of the baseline questionnaires from an ongoing prospective cohort study was conducted. Nine national players' associations and three rugby unions distributed questionnaires based on validated scales for assessing symptoms of common mental disorders. Among the whole study sample (N=990; overall response rate of 28%), prevalence (4-week) of symptoms of common mental disorders ranged from 15% for adverse alcohol use to 30% for anxiety/depression. These findings support the prevalence rates of symptoms of common mental disorders found in previous studies among professional (i. e., elite) athletes across other sports, and suggestions can be made that the prevalence of symptoms of anxiety/depression seems slightly higher in professional rugby than in other general/occupational populations. Awareness of the prevalence of symptoms of common mental disorders should be improved in international rugby, and an interdisciplinary approach including psychological attention should be fostered in the medical care of professional rugby players. Adequate supportive measures to enhance awareness and psychological resilience would lead not only to improved health and quality of life among rugby players but arguably to enhanced performance in rugby. © Georg Thieme Verlag KG Stuttgart · New York.

  9. Symptoms Of Common Mental Disorders In Professional Rugby: An International Observational Descriptive Study

    NARCIS (Netherlands)

    Gouttebarge, Vincent; Hopley, Phil; Kerkhoffs, Gino; Verhagen, Evert; Viljoen, Wayne; Wylleman, Paul; Lambert, Mike I.

    2017-01-01

    The aim of the study was to determine the prevalence of symptoms of common mental disorders among professional rugby players across countries. A cross-sectional analysis of the baseline questionnaires from an ongoing prospective cohort study was conducted. Nine national players' associations and

  10. High School Teachers' Perspectives on the English Language Arts Common Core State Standards: An Exploratory Study

    Science.gov (United States)

    Ajayi, Lasisi

    2016-01-01

    This was an exploratory study that examined high school teachers' perspectives about their early experiences with the English language arts Common Core State Standards. The sources of data for the study included a survey and structured interviews. Twenty-three high school ELA teachers from one unified school district in Southern California…

  11. Using the GlideinWMS System as a Common Resource Provisioning Layer in CMS

    Energy Technology Data Exchange (ETDEWEB)

    Balcas, J. [Vilnius U.; Belforte, S. [Trieste U.; Bockelman, B. [Nebraska U.; Colling, D. [Imperial Coll., London; Gutsche, O. [Fermilab; Hufnagel, D. [Fermilab; Khan, F. [Quaid-i-Azam U.; Larson, K. [Fermilab; Letts, J. [UC, San Diego; Mascheroni, M. [Milan Bicocca U.; Mason, D. [Fermilab; McCrea, A. [UC, San Diego; Piperov, S. [Brown U.; Saiz-Santos, M. [UC, San Diego; Sfiligoi, I. [UC, San Diego; Tanasijczuk, A. [UC, San Diego; Wissing, C. [DESY

    2015-12-23

    CMS will require access to more than 125k processor cores for the beginning of Run 2 in 2015 to carry out its ambitious physics program with more and higher complexity events. During Run1 these resources were predominantly provided by a mix of grid sites and local batch resources. During the long shut down cloud infrastructures, diverse opportunistic resources and HPC supercomputing centers were made available to CMS, which further complicated the operations of the submission infrastructure. In this presentation we will discuss the CMS effort to adopt and deploy the glideinWMS system as a common resource provisioning layer to grid, cloud, local batch, and opportunistic resources and sites. We will address the challenges associated with integrating the various types of resources, the efficiency gains and simplifications associated with using a common resource provisioning layer, and discuss the solutions found. We will finish with an outlook of future plans for how CMS is moving forward on resource provisioning for more heterogenous architectures and services.

  12. Rare and unusual ... or are they? Less commonly diagnosed encephalopathies associated with systemic disease.

    Science.gov (United States)

    Weathers, Allison L; Lewis, Steven L

    2009-04-01

    Encephalopathy due to hepatic or renal failure, electrolyte disturbances, or the administration of benzodiazepines and narcotics is commonly encountered, well reviewed in the literature, and, therefore, not usually missed. This article focuses on encephalopathies that were previously well described but may be overlooked by modern clinicians, as well as those that are still taught in the classroom but seldom thought of in practice. Due to the presumed relative rarity of these cases and emphasis on the well-memorized "classic" clinical presentations, these often treatable, and perhaps not so rare, encephalopathies due to systemic medical illness may go undiagnosed and untreated. Pancreatic encephalopathy, Wernicke's encephalopathy, and pellagra encephalopathy are reviewed in detail; cefepime and ifosfamide encephalopathies are discussed as examples of specific medication-induced encephalopathies. Septic encephalopathy, central pontine myelinolysis, and fat embolism syndrome are briefly reviewed. The encephalopathies reviewed have the potential for devastating neurological consequences if recognition and, therefore, treatment are delayed. Clinical improvement for many of these syndromes depends on prompt intervention. This article highlights some representative examples of less-commonly diagnosed metabolic and toxic encephalopathies.

  13. The Common Alerting Protocol (CAP) adaption in National Early Warning Alerting Systems of China

    Science.gov (United States)

    Li, Chao

    2017-04-01

    The Common Alerting Protocol (CAP) [1] is an XML-based data format for exchanging public warnings and emergencies between alerting technologies. In China, from local communities to entire nations, there was a patchwork of specialized hazard public alerting systems. And each system was often designed just for certain emergency situations and for certain communications media. Application took place in the NEWAS (National Early Warning Alerting Systems) [2]project where CAP serves as central message to integrate all kind of hazard situations, including the natural calamity, accident disaster, public health emergency , social safety etc. Officially operated on May 2015, NEWAS now has completed docking work with 14 departments including civil administration, safety supervision, forestry, land, water conservancy, earthquake, traffic, meteorology, agriculture, tourism, food and drug supervision, public security and oceanic administration. Thus, several items in CAP has been modified, redefined and extended according to the various grading standards and publishing strategies, as well as the characteristics of Chinese Geocoding. NEWAS successfully delivers information to end users through 4 levels (i.e. State, province, prefecture and county) structure and by various means. [1] CAP, http://www.oasis-emergency.org/cap [2] http://www.12379.cn/

  14. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.

    Science.gov (United States)

    Kasperaviciūte, Dalia; Catarino, Claudia B; Heinzen, Erin L; Depondt, Chantal; Cavalleri, Gianpiero L; Caboclo, Luis O; Tate, Sarah K; Jamnadas-Khoda, Jenny; Chinthapalli, Krishna; Clayton, Lisa M S; Shianna, Kevin V; Radtke, Rodney A; Mikati, Mohamad A; Gallentine, William B; Husain, Aatif M; Alhusaini, Saud; Leppert, David; Middleton, Lefkos T; Gibson, Rachel A; Johnson, Michael R; Matthews, Paul M; Hosford, David; Heuser, Kjell; Amos, Leslie; Ortega, Marcos; Zumsteg, Dominik; Wieser, Heinz-Gregor; Steinhoff, Bernhard J; Krämer, Günter; Hansen, Jörg; Dorn, Thomas; Kantanen, Anne-Mari; Gjerstad, Leif; Peuralinna, Terhi; Hernandez, Dena G; Eriksson, Kai J; Kälviäinen, Reetta K; Doherty, Colin P; Wood, Nicholas W; Pandolfo, Massimo; Duncan, John S; Sander, Josemir W; Delanty, Norman; Goldstein, David B; Sisodiya, Sanjay M

    2010-07-01

    Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease risk, the role of common variation in partial epilepsies has not yet been explored in a well-powered study. We undertook a genome-wide association-study to identify common variants which influence risk for epilepsy shared amongst partial epilepsy syndromes, in 3445 patients and 6935 controls of European ancestry. We did not identify any genome-wide significant association. A few single nucleotide polymorphisms may warrant further investigation. We exclude common genetic variants with effect sizes above a modest 1.3 odds ratio for a single variant as contributors to genetic susceptibility shared across the partial epilepsies. We show that, at best, common genetic variation can only have a modest role in predisposition to the partial epilepsies when considered across syndromes in Europeans. The genetic architecture of the partial epilepsies is likely to be very complex, reflecting genotypic and phenotypic heterogeneity. Larger meta-analyses are required to identify variants of smaller effect sizes (odds ratio<1.3) or syndrome-specific variants. Further, our results suggest research efforts should also be directed towards identifying the multiple rare variants likely to account for at least part of the heritability of the partial epilepsies. Data emerging from genome-wide association-studies will be valuable during the next serious challenge of interpreting all the genetic variation emerging from whole-genome sequencing studies.

  15. Agronomic performance of common bean in straw mulch systems and topdressing nitrogen rates in no-tillage

    Directory of Open Access Journals (Sweden)

    Tatiana Pagan Loeiro da Cunha

    2015-10-01

    Full Text Available ABSTRACTIn no-tillage systems, straw coverage on soil surface is the key to success, and the choice of crops for rotation is crucial to achieve the sustainability and quality that conservation agriculture requires. The objective of this study was to evaluate the agronomic performance of the common bean cultivar IAC Formoso sown in succession to three straw mulch systems (corn alone, corn/Urochloa ruziziensisintercrop and U. ruziziensisalone and topdress nitrogen rates (0; 40; 80; 120 and 160 kg ha-1N, at the four-leaf stage, three years after the implementation of no-tillage. The experiment was arranged in a randomized block split plot design, with three replications. Common bean highest yields were achieved in succession to U. ruziziensisalone and intercropped with corn. The corn/U. ruziziensisintercrop provided both straw and seed production, allowing for quality no-tillage. Topdressed nitrogen influenced the common bean yield when in succession to corn alone, U. ruziziensisalone and corn/U. ruziziensisintercrop in no-tillage.

  16. Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers.

    Directory of Open Access Journals (Sweden)

    Noriko Tonomura

    2015-02-01

    Full Text Available Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma, respectively. Golden retrievers in the US show significantly elevated lifetime risk for both B-cell lymphoma (6% and hemangiosarcoma (20%. We conducted genome-wide association studies for hemangiosarcoma and B-cell lymphoma, identifying two shared predisposing loci. The two associated loci are located on chromosome 5, and together contribute ~20% of the risk of developing these cancers. Genome-wide p-values for the top SNP of each locus are 4.6×10-7 and 2.7×10-6, respectively. Whole genome resequencing of nine cases and controls followed by genotyping and detailed analysis identified three shared and one B-cell lymphoma specific risk haplotypes within the two loci, but no coding changes were associated with the risk haplotypes. Gene expression analysis of B-cell lymphoma tumors revealed that carrying the risk haplotypes at the first locus is associated with down-regulation of several nearby genes including the proximal gene TRPC6, a transient receptor Ca2+-channel involved in T-cell activation, among other functions. The shared risk haplotype in the second locus overlaps the vesicle transport and release gene STX8. Carrying the shared risk haplotype is associated with gene expression changes of 100 genes enriched for pathways involved in immune cell activation. Thus, the predisposing germ-line mutations in B-cell lymphoma and hemangiosarcoma appear to be regulatory, and affect pathways involved in T-cell mediated immune response in the tumor. This suggests that the interaction between the immune system and malignant cells plays a common role in the tumorigenesis of these relatively different cancers.

  17. Cochlear implantation outcomes in children with common cavity deformity; a retrospective study.

    Science.gov (United States)

    Zhang, Li; Qiu, Jianxin; Qin, Feifei; Zhong, Mei; Shah, Gyanendra

    2017-09-01

    A common cavity deformity (CCD) is a deformed inner ear in which the cochlea and vestibule are confluent forming a common rudimentary cystic cavity that results in profound hearing loss. There are few studies paying attention to common cavity. Our group is engrossed in observing the improvement of auditory and verbal abilities in children who have received cochlear implantation (CI), and comparing these targets between children with common cavity and normal inner ear structure. A retrospective study was conducted in 12 patients with profound hearing loss that were divided into a common cavity group and a control group, six in each group matched in sex, age and time of implantation, based on inner ear structure. Categories of Auditory Performance (CAP) and speech intelligibility rating (SIR) scores and aided hearing thresholds were collected and compared between the two groups. All patients wore CI for more than 1 year at the Cochlear Center of Anhui Medical University from 2011 to 2015. Postoperative CAP and SIR scores were higher than before operation in both groups (p good as in those without CCD, CI provides benefits in auditory perception and communication skills in these children.

  18. Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case–control study

    International Nuclear Information System (INIS)

    Tamimi, Rulla M; Hankinson, Susan E; Spiegelman, Donna; Kraft, Peter; Colditz, Graham A; Hunter, David J

    2004-01-01

    The ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family studies, women heterozygous for mutations in the ATM gene are reported to have a fourfold to fivefold increased risk of breast cancer compared with noncarriers of the mutations, although not all studies have confirmed this association. Haplotype analysis has been suggested as an efficient method for investigating the role of common variation in the ATM gene and breast cancer. Five biallelic haplotype tagging single nucleotide polymorphisms are estimated to capture 99% of the haplotype diversity in Caucasian populations. We conducted a nested case–control study of breast cancer within the Nurses' Health Study cohort to address the role of common ATM haplotypes and breast cancer. Cases and controls were genotyped for five haplotype tagging single nucleotide polymorphisms. Haplotypes were predicted for 1309 cases and 1761 controls for which genotype information was available. Six unique haplotypes were predicted in this study, five of which occur at a frequency of 5% or greater. The overall distribution of haplotypes was not significantly different between cases and controls (χ 2 = 3.43, five degrees of freedom, P = 0.63). There was no evidence that common haplotypes of ATM are associated with breast cancer risk. Extensive single nucleotide polymorphism detection using the entire genomic sequence of ATM will be necessary to rule out less common variation in ATM and sporadic breast cancer risk

  19. Exploring Specialized STEM High Schools: Three Dissertation Studies Examining Commonalities and Differences Across Six Case Studies

    Science.gov (United States)

    Tofel-Grehl, Colby

    This dissertation is comprised of three independently conducted analyses of a larger investigation into the practices and features of specialized STEM high schools. While educators and policy makers advocate the development of many new specialized STEM high schools, little is known about the unique features and practices of these schools. The results of these manuscripts add to the literature exploring the promise of specialized STEM schools. Manuscript 1¹ is a qualitative investigation of the common features of STEM schools across multiple school model types. Schools were found to possess common cultural and academic features regardless of model type. Manuscript 2² builds on the findings of manuscript 1. With no meaningful differences found attributable to model type, the researchers used grounded theory to explore the relationships between observed differences among programs as related to the intensity of the STEM experience offered at schools. Schools were found to fall into two categories, high STEM intensity (HSI) and low STEM intensity (LSI), based on five major traits. Manuscript 3³ examines the commonalities and differences in classroom discourse and teachers' questioning techniques in STEM schools. It explicates these discursive practices in order to explore instructional practices across schools. It also examines factors that may influence classroom discourse such as discipline, level of teacher education, and course status as required or elective. Collectively, this research furthers the agenda of better understanding the potential advantages of specialized STEM high schools for preparing a future scientific workforce. ¹Tofel-Grehl, C., Callahan, C., & Gubbins, E. (2012). STEM high school communities: Common and differing features. Manuscript in preparation. ²Tofel-Grehl, C., Callahan, C., & Gubbins, E. (2012). Variations in the intensity of specialized science, technology, engineering, and mathematics (STEM) high schools. Manuscript in preparation

  20. Are Lotus species good models for studying iron accumulation in common beans?

    DEFF Research Database (Denmark)

    Orlowska, Elzbieta; Laszcyca, Katarzyna Malgorzata; Urbanski, Dorian Fabian

    show that the iron distribution in L. filicaulis seeds is similar to that  in common beans, while the seeds of L. japonicus show a different pattern of iron accumulation. RILs from a cross between these two species are being studied in order to find genes that are important for seed iron distribution...

  1. Design Core Commonalities: A Study of the College of Design at Iowa State University

    Science.gov (United States)

    Venes, Jane

    2015-01-01

    This comprehensive study asks what a group of rather diverse disciplines have in common. It involves a cross-disciplinary examination of an entire college, the College of Design at Iowa State University. This research was intended to provide a sense of direction in developing and assessing possible core content. The reasoning was that material…

  2. Endocrine active contaminants in aquatic systems and intersex in common sport fishes

    Science.gov (United States)

    Lee Pow, Crystal S. D.; Law, J. Mac; Kwak, Thomas J.; Cope, W. Gregory; Rice, James A.; Kullman, Seth W.; Aday, D. Derek

    2017-01-01

    Male fish are susceptible to developing intersex, a condition characterized by the presence of testicular oocytes. In the present study, the relationship between intersex and exposure to estrogenic endocrine active contaminants (EACs) was assessed for 2 genera of sport fish, Micropterus and Lepomis, at 20 riverine sites. Seasonal trends and relationships between EACs and intersex (prevalence and severity) were examined at varying putative sources of EACs throughout North Carolina, identified as point sources, nonpoint sources, and reference sites. Intersex was identified in both genera, which was documented for the first time in wild-caught Lepomis. Intersex was more prevalent (59.8%) and more severe (1.6 mean rank) in Micropterus, which was highly correlation to EACs in sediment. In contrast, intersex was less common (9.9%) and less severe (0.2 mean rank) in Lepomis and was highly correlated to EACs in the water column. The authors found that concentrations of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, industrial EACs, and estrogens were highest at point source sites; however, no source type variation was identified in the prevalence or severity of intersex, nor were there seasonal trends in intersex or EAC concentrations. The authors’ results associate genus-specific prevalence of intersex with specific EAC classes in common sport fishes having biological, ecological, and conservation implications.

  3. Systemic lupus erythematosus pancreatitis: an uncommon presentation of a common disease.

    Science.gov (United States)

    Rodriguez, Eduardo A; Sussman, Daniel A; Rodriguez, Vanessa R

    2014-11-17

    Acute pancreatitis is uncommon in systemic lupus erythematosus (SLE). When recognized early and properly treated with IV steroids and hydration, the course may be benign, as exemplified in the following report. A 21-year-old woman with history of SLE and stage IV lupus nephritis, was admitted to the Sergio Bernales Hospital ICU (Lima, Peru), complaining of worsening epigastric pain radiating to the back, and nausea and vomiting for 1 week. She denied prior cholelithiasis, alcohol use, or recent medication changes. On examination, she was tachycardic and normotensive, with a slightly distended abdomen and epigastric tenderness on deep palpation, without signs of peritoneal irritation. Laboratory results demonstrated leukocytosis without left shift, creatinine of 2.26 mg/dL, amylase of 750 U/L, and lipase of 1038 U/L. Liver chemistries, calcium, lactic acid, triglycerides, and IgG4 were normal and alcohol level was undetectable. Ultrasound did not show cholelithiasis, biliary sludge, or common bile duct dilation. CT of the abdomen showed pancreas head (parenchyma) stranding with uniform enhancement consistent with interstitial pancreatitis. Despite receiving IV fluids, opiates, anti-emetics, and nothing by mouth, her clinical condition deteriorated, prompting the use of IV methylprednisolone. After completing 1 week of IV steroids, she was transferred to the medical floor clinically improved. The patient was discharged with an oral steroid taper and complete resolution of symptoms. After ruling out common causes, such as hepatobiliary pathology or toxin-related insults like alcohol, hypercalcemia, hypertriglyceridemia or medications, steroids may be used in SLE pancreatitis because they might improve the overall prognosis.

  4. An ERP Study of the Processing of Common and Decimal Fractions: How Different They Are

    Science.gov (United States)

    Zhang, Li; Wang, Qi; Lin, Chongde; Ding, Cody; Zhou, Xinlin

    2013-01-01

    This study explored event-related potential (ERP) correlates of common fractions (1/5) and decimal fractions (0.2). Thirteen subjects performed a numerical magnitude matching task under two conditions. In the common fraction condition, a nonsymbolic fraction was asked to be judged whether its magnitude matched the magnitude of a common fraction; in the decimal fraction condition, a nonsymbolic fraction was asked to be matched with a decimal fraction. Behavioral results showed significant main effects of condition and numerical distance, but no significant interaction of condition and numerical distance. Electrophysiological data showed that when nonsymbolic fractions were compared to common fractions, they displayed larger N1 and P3 amplitudes than when they were compared to decimal fractions. This finding suggested that the visual identification for nonsymbolic fractions was different under the two conditions, which was not due to perceptual differences but to task demands. For symbolic fractions, the condition effect was observed in the N1 and P3 components, revealing stimulus-specific visual identification processing. The effect of numerical distance as an index of numerical magnitude representation was observed in the P2, N3 and P3 components under the two conditions. However, the topography of the distance effect was different under the two conditions, suggesting stimulus specific semantic processing of common fractions and decimal fractions. PMID:23894491

  5. An ERP study of the processing of common and decimal fractions: how different they are.

    Directory of Open Access Journals (Sweden)

    Li Zhang

    Full Text Available This study explored event-related potential (ERP correlates of common fractions (1/5 and decimal fractions (0.2. Thirteen subjects performed a numerical magnitude matching task under two conditions. In the common fraction condition, a nonsymbolic fraction was asked to be judged whether its magnitude matched the magnitude of a common fraction; in the decimal fraction condition, a nonsymbolic fraction was asked to be matched with a decimal fraction. Behavioral results showed significant main effects of condition and numerical distance, but no significant interaction of condition and numerical distance. Electrophysiological data showed that when nonsymbolic fractions were compared to common fractions, they displayed larger N1 and P3 amplitudes than when they were compared to decimal fractions. This finding suggested that the visual identification for nonsymbolic fractions was different under the two conditions, which was not due to perceptual differences but to task demands. For symbolic fractions, the condition effect was observed in the N1 and P3 components, revealing stimulus-specific visual identification processing. The effect of numerical distance as an index of numerical magnitude representation was observed in the P2, N3 and P3 components under the two conditions. However, the topography of the distance effect was different under the two conditions, suggesting stimulus specific semantic processing of common fractions and decimal fractions.

  6. Dose audit for patients undergoing two common radiography examinations with digital radiology systems

    Science.gov (United States)

    İnal, Tolga; Ataç, Gökçe

    2014-01-01

    PURPOSE We aimed to determine the radiation doses delivered to patients undergoing general examinations using computed or digital radiography systems in Turkey. MATERIALS AND METHODS Radiographs of 20 patients undergoing posteroanterior chest X-ray and of 20 patients undergoing anteroposterior kidney-ureter-bladder radiography were evaluated in five X-ray rooms at four local hospitals in the Ankara region. Currently, almost all radiology departments in Turkey have switched from conventional radiography systems to computed radiography or digital radiography systems. Patient dose was measured for both systems. The results were compared with published diagnostic reference levels (DRLs) from the European Union and International Atomic Energy Agency. RESULTS The average entrance surface doses (ESDs) for chest examinations exceeded established international DRLs at two of the X-ray rooms in a hospital with computed radiography. All of the other ESD measurements were approximately equal to or below the DRLs for both examinations in all of the remaining hospitals. Improper adjustment of the exposure parameters, uncalibrated automatic exposure control systems, and failure of the technologists to choose exposure parameters properly were problems we noticed during the study. CONCLUSION This study is an initial attempt at establishing local DRL values for digital radiography systems, and will provide a benchmark so that the authorities can establish reference dose levels for diagnostic radiology in Turkey. PMID:24317331

  7. Dose audit for patients undergoing two common radiography examinations with digital radiology systems.

    Science.gov (United States)

    İnal, Tolga; Ataç, Gökçe

    2014-01-01

    We aimed to determine the radiation doses delivered to patients undergoing general examinations using computed or digital radiography systems in Turkey. Radiographs of 20 patients undergoing posteroanterior chest X-ray and of 20 patients undergoing anteroposterior kidney-ureter-bladder radiography were evaluated in five X-ray rooms at four local hospitals in the Ankara region. Currently, almost all radiology departments in Turkey have switched from conventional radiography systems to computed radiography or digital radiography systems. Patient dose was measured for both systems. The results were compared with published diagnostic reference levels (DRLs) from the European Union and International Atomic Energy Agency. The average entrance surface doses (ESDs) for chest examinations exceeded established international DRLs at two of the X-ray rooms in a hospital with computed radiography. All of the other ESD measurements were approximately equal to or below the DRLs for both examinations in all of the remaining hospitals. Improper adjustment of the exposure parameters, uncalibrated automatic exposure control systems, and failure of the technologists to choose exposure parameters properly were problems we noticed during the study. This study is an initial attempt at establishing local DRL values for digital radiography systems, and will provide a benchmark so that the authorities can establish reference dose levels for diagnostic radiology in Turkey.

  8. A Detailed Analysis of Prehospital Interventions in Common Medical Priority Dispatch System Determinants

    Directory of Open Access Journals (Sweden)

    Sporer, Karl A

    2011-02-01

    Full Text Available Background: Medical Priority Dispatch System (MPDS is a type of Emergency Medical Dispatch (EMD system used to prioritize 9-1-1 calls and optimize resource allocation. Dispatchers use a series of scripted questions to assign determinants to calls based on chief complaint and acuity.Objective: We analyzed the prehospital interventions performed on patients with MPDS determinants for breathing problems, chest pain, unknown problem (man down, seizures, fainting (unconscious and falls for transport status and interventions.Methods: We matched all prehospital patients in complaint-based categories for breathing problems, chest pain, unknown problem (man down, seizures, fainting (unconscious and falls from January 1, 2004, to December 31, 2006, with their prehospital record. Calls were queried for the following prehospital interventions: Basic Life Support care only, intravenous line placement only, medication given, procedures or non-transport. We defined Advanced Life Support (ALS interventions as the administration of a medication or a procedure.Results: Of the 77,394 MPDS calls during this period, 31,318 (40% patients met inclusion criteria. Breathing problems made up 12.2%, chest pain 6%, unknown problem 1.4%, seizures 3%, falls 9% and unconscious/fainting 9% of the total number of MPDS calls. Patients with breathing problem had a low rate of procedures (0.7% and cardiac arrest medications (1.6% with 38% receiving some medication. Chest pain patients had a similar distribution; procedures (0.5%, cardiac arrest medication (1.5% and any medication (64%. Unknown problem: procedures (1%, cardiac arrest medication (1.3%, any medication (18%. Patients with Seizures had a low rate of procedures (1.1% and cardiac arrest medications (0.6% with 20% receiving some medication. Fall patients had a lower rate of severe illness with more medication, mostly morphine: procedures (0.2%, cardiac arrest medication (0.2%, all medications (28%. Unconscious

  9. Procedures for treating common cause failures in safety and reliability studies: Analytical background and techniques

    International Nuclear Information System (INIS)

    Mosleh, A.; Fleming, K.N.; Parry, G.W.; Paula, H.M.; Worledge, D.H.; Rasmuson, D.M.

    1989-01-01

    Volume I of this report presents a framework for the inclusion of the impact of common cause failures in risk and reliability evaluations. Common cause failures are defined as that subset of dependent failures for which causes are not explicitly included in the logic model as basic events. The emphasis here is on providing procedures for a practical, systematic approach that can be used to perform and clearly document the analysis. The framework and the methods discussed for performing the different stages of the analysis integrate insights obtained from engineering assessments of the system and the historical evidence from multiple failure events into a systematic, reproducible, and defensible analysis. This document, Volume 2, contains a series of appendices that provide additional background and methodological detail on several important topics discussed in Volume I

  10. BWID System Design Study

    International Nuclear Information System (INIS)

    O'Brien, M.C.; Rudin, M.J.; Morrison, J.L.; Richardson, J.G.

    1991-01-01

    The mission of the Buried Waste Integrated Demonstration (BWID) System Design Study is to identify and evaluate technology process options for the cradle-to-grave remediation of Transuranic (TRU)-Contaminated Waste Pits and Trenches buried at the Idaho National Engineering Laboratory (INEL). Emphasis is placed upon evaluating system configuration options and associated functional and operational requirements for retrieving and treating the buried wastes. A Performance-Based Technology Selection Filter was developed to evaluate the identified remediation systems and their enabling technologies based upon system requirements and quantification of technical Comprehensive Environmental Response, Compensation, and Liability (CERCLA) balancing criteria. Remediation systems will also be evaluated with respect to regulatory and institutional acceptance and cost-effectiveness

  11. Feasibility of Combining Common Data Elements Across Studies to Test a Hypothesis.

    Science.gov (United States)

    Corwin, Elizabeth J; Moore, Shirley M; Plotsky, Andrea; Heitkemper, Margaret M; Dorsey, Susan G; Waldrop-Valverde, Drenna; Bailey, Donald E; Docherty, Sharron L; Whitney, Joanne D; Musil, Carol M; Dougherty, Cynthia M; McCloskey, Donna J; Austin, Joan K; Grady, Patricia A

    2017-05-01

    The purpose of this article is to describe the outcomes of a collaborative initiative to share data across five schools of nursing in order to evaluate the feasibility of collecting common data elements (CDEs) and developing a common data repository to test hypotheses of interest to nursing scientists. This initiative extended work already completed by the National Institute of Nursing Research CDE Working Group that successfully identified CDEs related to symptoms and self-management, with the goal of supporting more complex, reproducible, and patient-focused research. Two exemplars describing the group's efforts are presented. The first highlights a pilot study wherein data sets from various studies by the represented schools were collected retrospectively, and merging of the CDEs was attempted. The second exemplar describes the methods and results of an initiative at one school that utilized a prospective design for the collection and merging of CDEs. Methods for identifying a common symptom to be studied across schools and for collecting the data dictionaries for the related data elements are presented for the first exemplar. The processes for defining and comparing the concepts and acceptable values, and for evaluating the potential to combine and compare the data elements are also described. Presented next are the steps undertaken in the second exemplar to prospectively identify CDEs and establish the data dictionaries. Methods for common measurement and analysis strategies are included. Findings from the first exemplar indicated that without plans in place a priori to ensure the ability to combine and compare data from disparate sources, doing so retrospectively may not be possible, and as a result hypothesis testing across studies may be prohibited. Findings from the second exemplar, however, indicated that a plan developed prospectively to combine and compare data sets is feasible and conducive to merged hypothesis testing. Although challenges exist in

  12. The role of job strain in understanding midlife common mental disorder: a national birth cohort study.

    Science.gov (United States)

    Harvey, Samuel B; Sellahewa, Dilan A; Wang, Min-Jung; Milligan-Saville, Josie; Bryan, Bridget T; Henderson, Max; Hatch, Stephani L; Mykletun, Arnstein

    2018-06-01

    Long-standing concerns exist about reverse causation and residual confounding in the prospective association between job strain and risk of future common mental disorders. We aimed to address these concerns through analysis of data collected in the UK National Child Development Study, a large British cohort study. Data from the National Child Development Study (n=6870) were analysed by use of multivariate logistic regression to investigate the prospective association between job strain variables at age 45 years and risk of future common mental disorders at age 50 years, controlling for lifetime psychiatric history and a range of other possible confounding variables across the lifecourse. Population attributable fractions were calculated to estimate the public health effect of job strain on midlife mental health. In the final model, adjusted for all measured confounders, high job demands (odds ratio 1·70, 95% CI 1·25-2·32; p=0·0008), low job control (1·89, 1·29-2·77; p=0·0010), and high job strain (2·22, 1·59-3·09; pmental disorder. If causality is assumed, our findings suggest that 14% of new cases of common mental disorder could have been prevented through elimination of high job strain (population attributable fraction 0·14, 0·06-0·20). High job strain appears to independently affect the risk of future common mental disorders in midlife. These findings suggest that modifiable work-related risk factors might be an important target in efforts to reduce the prevalence of common mental disorders. iCare Foundation and Mental Health Branch, NSW Health. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. Mental health research in the criminal justice system: The need for common approaches and international perspectives.

    Science.gov (United States)

    Roesch, R; Ogloff, J R; Eaves, D

    1995-01-01

    There is a need for researchers and policy makers in the area of mental health and law to collaborate and develop common methods of approach to research. Although we have learned a great deal about the prevalence and needs of mentally ill offenders in jails and prisons, there are a number of research questions that remain. If the "second generation" of research is to be fruitful--and useful to policy makers--we need to be sure that the methods we employ are valid and that the findings we obtain are reliable. By collaborating with colleagues in other jurisdictions, we can begin to learn whether some of the existing findings are of a general nature, or dependent upon the system in which they were found. Similarly, while the first-generation research has alerted us to the needs of mentally ill offenders in jails and prisons, second-generation research is needed to help identify factors that may help prevent the "revolving door phenomenon," which results in mentally ill people being volleyed among mental health, criminal justice, and community settings. One area that has received embarrassingly little attention has been the need for considering the relationship between substance abuse and mental disorders. In our own work, we have found an alarmingly high degree of substance abuse among offenders, including mentally ill offenders. We have come to realize the importance of considering the role that substance abuse coupled with other mental disorders may play in the criminal justice system. As a result of this concern, the Surrey Mental Health Project recently hired a full-time drug and alcohol counselor whose job it is to work with inmates with substance abuse disorders while in the jail, and to help arrange continuing treatment resources upon their release. As Wilson et al. (1995) discuss, intensive case management projects may be particularly useful at targeting the unique needs of mentally ill offenders with multiple problems. Much of the research conducted with

  14. Dextromethorphan Addiction Mediated Through the NMDA System: Common Pathways With Alcohol?

    Science.gov (United States)

    Roy, A Kenison; Hsieh, Chenen; Crapanzano, Kathleen

    2015-01-01

    Dextromethorphan, an antitussive (cough suppressant) drug of the morphinan class with sedative and dissociative properties found in cough syrup and other over-the-counter products, is also a substance of abuse, seen primarily in young adults all over the world. A case of dextromethorphan use disorder is presented in a 45-year-old women. Her repeated attempts at abstinence were unsuccessful secondary to continued intense cravings. Treatment with topiramate resulted in complete resolution of her cravings. Topiramate was chosen empirically because of a common action with dextromethorphan in the NMDA system. Genetic testing was obtained and the patient was found to be a carrier of the GRIK1 rs2832407(C:C) allele. The (C:C) allele has been associated with an increased risk of alcohol use disorder and a treatment response of patients with heavy drinking to topiramate. This case provides an opportunity to discuss personalized medicine (treatment options aided by the use of genetic testing) and the possible shared genetic susceptibility for dependence in 2 substances of abuse.

  15. Transaction processing in the common node of a distributed function laboratory computer system

    International Nuclear Information System (INIS)

    Stubblefield, F.W.; Dimmler, D.G.

    1975-01-01

    A computer network architecture consisting of a common node processor for managing peripherals and files and a number of private node processors for laboratory experiment control is briefly reviewed. Central to the problem of private node-common node communication is the concept of a transaction. The collection of procedures and the data structure associated with a transaction are described. The common node properties assigned to a transaction and procedures required for its complete processing are discussed. (U.S.)

  16. Connection of European particle therapy centers and generation of a common particle database system within the European ULICE-framework

    International Nuclear Information System (INIS)

    Kessel, Kerstin A; Pötter, Richard; Dosanjh, Manjit; Debus, Jürgen; Combs, Stephanie E; Bougatf, Nina; Bohn, Christian; Habermehl, Daniel; Oetzel, Dieter; Bendl, Rolf; Engelmann, Uwe; Orecchia, Roberto; Fossati, Piero

    2012-01-01

    To establish a common database on particle therapy for the evaluation of clinical studies integrating a large variety of voluminous datasets, different documentation styles, and various information systems, especially in the field of radiation oncology. We developed a web-based documentation system for transnational and multicenter clinical studies in particle therapy. 560 patients have been treated from November 2009 to September 2011. Protons, carbon ions or a combination of both, as well as a combination with photons were applied. To date, 12 studies have been initiated and more are in preparation. It is possible to immediately access all patient information and exchange, store, process, and visualize text data, any DICOM images and multimedia data. Accessing the system and submitting clinical data is possible for internal and external users. Integrated into the hospital environment, data is imported both manually and automatically. Security and privacy protection as well as data validation and verification are ensured. Studies can be designed to fit individual needs. The described database provides a basis for documentation of large patient groups with specific and specialized questions to be answered. Having recently begun electronic documentation, it has become apparent that the benefits lie in the user-friendly and timely workflow for documentation. The ultimate goal is a simplification of research work, better study analyses quality and eventually, the improvement of treatment concepts by evaluating the effectiveness of particle therapy

  17. Connection of European particle therapy centers and generation of a common particle database system within the European ULICE-framework

    Directory of Open Access Journals (Sweden)

    Kessel Kerstin A

    2012-07-01

    Full Text Available Abstract Background To establish a common database on particle therapy for the evaluation of clinical studies integrating a large variety of voluminous datasets, different documentation styles, and various information systems, especially in the field of radiation oncology. Methods We developed a web-based documentation system for transnational and multicenter clinical studies in particle therapy. 560 patients have been treated from November 2009 to September 2011. Protons, carbon ions or a combination of both, as well as a combination with photons were applied. To date, 12 studies have been initiated and more are in preparation. Results It is possible to immediately access all patient information and exchange, store, process, and visualize text data, any DICOM images and multimedia data. Accessing the system and submitting clinical data is possible for internal and external users. Integrated into the hospital environment, data is imported both manually and automatically. Security and privacy protection as well as data validation and verification are ensured. Studies can be designed to fit individual needs. Conclusions The described database provides a basis for documentation of large patient groups with specific and specialized questions to be answered. Having recently begun electronic documentation, it has become apparent that the benefits lie in the user-friendly and timely workflow for documentation. The ultimate goal is a simplification of research work, better study analyses quality and eventually, the improvement of treatment concepts by evaluating the effectiveness of particle therapy.

  18. Joint Polar Satellite System (JPSS) Common Ground System (CGS) Technical Performance Measures of the Block 2 Architecture

    Science.gov (United States)

    Grant, K. D.; Panas, M.

    2016-12-01

    NOAA and NASA are jointly acquiring the next-generation civilian weather satellite system: the Joint Polar Satellite System (JPSS). JPSS replaced the afternoon orbit component and ground processing of NOAA's old POES system. JPSS satellites carry sensors that collect meteorological, oceanographic, climatological, and solar-geophysical observations of the earth, atmosphere, and space. The ground processing system for JPSS is known as the JPSS Common Ground System (JPSS CGS). Developed and maintained by Raytheon Intelligence, Information and Services (IIS), the CGS is a globally distributed, multi-mission system serving NOAA, NASA and their national and international partners. The CGS has demonstrated its scalability and flexibility to incorporate multiple missions efficiently and with minimal cost, schedule and risk, while strengthening global partnerships in weather and environmental monitoring. The CGS architecture has been upgraded to Block 2.0 to satisfy several key objectives, including: "operationalizing" the first satellite, Suomi NPP, which originally was a risk reduction mission; leveraging lessons learned in multi-mission support, taking advantage of newer, more reliable and efficient technologies and satisfying constraints due of the continually evolving budgetary environment. To ensure the CGS meets these needs, we have developed 48 Technical Performance Measures (TPMs) across 9 categories: Data Availability, Data Latency, Operational Availability, Margin, Scalability, Situational Awareness, Transition (between environments and sites), WAN Efficiency, and Data Recovery Processing. This paper will provide an overview of the CGS Block 2.0 architecture, with particular focus on the 9 TPM categories listed above. We will describe how we ensure the deployed architecture meets these TPMs to satisfy our multi-mission objectives with the deployment of Block 2.0.

  19. Portable treatment systems study

    Energy Technology Data Exchange (ETDEWEB)

    Sherick, M.J.; Schwinkendorf, W.E.; Bechtold, T.E.; Cole, L.T.

    1997-03-01

    In developing their Site Treatment Plans (STPs), many of the Department of Energy installations identified some form of portable treatment, to facilitate compliant disposition of select mixed low-level wastestreams. The Environmental Management Office of Science and Technology requested that a systems study be performed to better define the potential role of portable treatment with respect to mixed low-level waste, highlight obstacles to implementation, and identify opportunities for future research and development emphasis. The study was performed by first establishing a representative set of mixed waste, then formulating portable treatment system concepts to meet the required processing needs for these wastes. The portable systems that were conceptualized were evaluated and compared to a fixed centralized treatment alternative. The system evaluations include a life-cycle cost analysis and an assessment of regulatory, institutional, and technical issues associated with the potential use of portable systems. The results of this study show that when all costs are included, there are no significant cost differences between portable systems and fixed systems. However, it is also emphasized that many uncertainties exist that could impact the cost of implementing portable treatment systems. Portable treatment could be made more attractive through private sector implementation, although there is little economic incentive for a commercial vendor to develop small, specialized treatment capabilities with limited applicability. Alternatively, there may also be valid reasons why fixed units cannot be used for some problematic wastestreams. In any event, there are some site-specific problems that still need to be addressed, and there may be some opportunity for research and development to make a positive impact in these areas.

  20. Portable treatment systems study

    International Nuclear Information System (INIS)

    Sherick, M.J.; Schwinkendorf, W.E.; Bechtold, T.E.; Cole, L.T.

    1997-03-01

    In developing their Site Treatment Plans (STPs), many of the Department of Energy installations identified some form of portable treatment, to facilitate compliant disposition of select mixed low-level wastestreams. The Environmental Management Office of Science and Technology requested that a systems study be performed to better define the potential role of portable treatment with respect to mixed low-level waste, highlight obstacles to implementation, and identify opportunities for future research and development emphasis. The study was performed by first establishing a representative set of mixed waste, then formulating portable treatment system concepts to meet the required processing needs for these wastes. The portable systems that were conceptualized were evaluated and compared to a fixed centralized treatment alternative. The system evaluations include a life-cycle cost analysis and an assessment of regulatory, institutional, and technical issues associated with the potential use of portable systems. The results of this study show that when all costs are included, there are no significant cost differences between portable systems and fixed systems. However, it is also emphasized that many uncertainties exist that could impact the cost of implementing portable treatment systems. Portable treatment could be made more attractive through private sector implementation, although there is little economic incentive for a commercial vendor to develop small, specialized treatment capabilities with limited applicability. Alternatively, there may also be valid reasons why fixed units cannot be used for some problematic wastestreams. In any event, there are some site-specific problems that still need to be addressed, and there may be some opportunity for research and development to make a positive impact in these areas

  1. Genetic association study of common mitochondrial variants on body fat mass.

    Directory of Open Access Journals (Sweden)

    Tie-Lin Yang

    Full Text Available Mitochondria play a central role in ATP production and energy metabolism. Previous studies suggest that common variants in mtDNA are associated with several common complex diseases, including obesity. To test the hypothesis that common mtDNA variants influence obesity-related phenotypes, including BMI and body fat mass, we genotyped a total of 445 mtSNPs across the whole mitochondrial genome in a large sample of 2,286 unrelated Caucasian subjects. 72 of these 445 mtSNPs passed quality control criteria, and were used for subsequent analyses. We also classified all subjects into nine common European haplogroups. Association analyses were conducted for both BMI and body fat mass with single mtSNPs and mtDNA haplogroups. Two mtSNPs, mt4823 and mt8873 were detected to be significantly associated with body fat mass, with adjusted P values of 4.94 × 10⁻³ and 4.58 × 10⁻², respectively. The minor alleles mt4823 C and mt8873 A were associated with reduced fat mass values and the effect size (β was estimated to be 3.52 and 3.18, respectively. These two mtSNPs also achieved nominally significant levels for association with BMI. For haplogroup analyses, we found that haplogroup X was strongly associated with both BMI (adjusted P = 8.31 × 10⁻³ and body fat mass (adjusted P = 5.67×10⁻⁴ Subjects classified as haplogroup X had lower BMI and fat mass values, with the β estimated to be 2.86 and 6.03, respectively. Our findings suggest that common variants in mitochondria might play a role in variations of body fat mass. Further molecular and functional studies will be needed to clarify the potential mechanism.

  2. STUDY OF THE ADAPTATION PROCESS IN COMMON CARP (CYPRINUS CARPIO L.) AFTER HARVESTING

    OpenAIRE

    Milena Bušová; Kristýna Štancelová

    2013-01-01

    Fish is sensitive to exogenous and endogenous ammonia. Ammonia formed in fish as a product of metabolism of proteins may be under certain circumstances life-threatening. Ammonia autointoxication is a serious problem and can cause mass mortalities in fish farms. This study focused on the common carp Cyprinus carpio L. in large-capacity breeding farms. It was focused on monitoring the blood ammonia levels in fish blood in the period of metabolic attenuation and the influence of harvesting and h...

  3. Characterization of Micrococcus luteus and Bacillus marisflavi Recovered from Common Dentex (Dentex dentex Larviculture System

    Directory of Open Access Journals (Sweden)

    T. AKAYLI

    2015-09-01

    Full Text Available In this manuscript, thirty yellow-pigmented Gram-positive bacteria were isolated from natural intestine microflora and from sea water around the marine cage of a rearing tank of common dentex (Dentex dentex, in the Aegean Sea on the Turkish coast and were characterized. Eighteen isolates were assigned to the species Micrococcus luteus, the other twelve to the species Bacillus marisflavi. Eight representative strains, six from B. marisflavi and two from M. luteus, were chosen for further 16S rDNA analyses. A pathogenicity assay for the isolated bacterial strains was carried out in rainbow trout and it evidenced absence of pathogenicity in the tested strains. The isolated strains were tested for in vitro antagonistic activity against Listonella anguillarum, a pathogen bacterium diffused in Mediterranean aquaculture and affecting various fish species. The isolated bacterial strains showed antagonistic activity against the pathogenic bacterium, suggesting a possible role of isolates as probiotics. In this study, for the first time, bacterial strains of the species B. marisflavi, known as an environmental species, were recovered in the gut microbiota of a healthy fish. The use of the isolates characterized in this study, mainly the yellow-pigmented bacterium, is suggested as possible probiotics to improve fish health, along with alternative methods of maintaining a healthy environment.

  4. A regional study of the radiation environment of Greenham Common, Newbury District and surrounding areas

    International Nuclear Information System (INIS)

    1997-02-01

    This study was commissioned by Newbury District Council and Basingstoke and Deane Borough Council in response to public concern following disclosures about events at Greenham Common in the 1950s, and the suspicion that there may have been an accident involving a nuclear weapon leading to off-site contamination at the airbase. The Greenham Common airbase is at an advanced stage of decommissioning with parts of the site already re-developed for industrial and leisure purposes and material being removed for use in construction of the Newbury by-pass. The success of such developments is critically dependent on public confidence in the quality of the environment, both near the site, and more generally throughout the area. For this reason the study was commissioned with the aims of: I. defining the radiation environment of the whole district and parts of its surrounding areas. II. examining whether there is any evidence of radioactive contamination in the vicinity of the Greenham Common airbase. III. assessing the evidence that there may have been a release of nuclear material from the site. The work involved a collaboration between scientists from the Scottish Universities Research and Reactor Centre, who conducted gamma ray surveys to define the general radiation environment of the area, and Scientists from the University of Southampton who collected an extensive range of samples for high sensitivity radiochemical analyses. This report presents their findings and main conclusions, together with a discussion of the background to the study and its implications. (Author)

  5. Study of Four Common Mutations of Familial Mediterranean Fever in North-West of Iran

    Directory of Open Access Journals (Sweden)

    Abbas Karimi

    2012-09-01

    Full Text Available Background and Objectives : Familial Mediterranean Fever, an autosomal recessive disorder, is the most common and well known periodical fevers syndrome. Disease is mainly prevalent among non-Ashkenazi Jews, Arabs, Turks and Armenia. According to the geographical location of North-West of Iran, neighboring with two high risk FMF population (Turkey and Armenia, the prevalence of FMF in this region of Iran is not unlikely. The aim of this study was to estimate the carriers rate of FMF common mutations in healthy control people. Results can be potentially useful to estimate prevalence of disease.   Methods : Randomly 200 samples from healthy people [non-FMF] from North-West of Iran selected. After taking consent, DNA was extracted from blood samples of these groups. Then mutations were evaluated using ARMS-PCR and RFLP-PCR techniques.   Results : from 400 studied alleles, 44 and 7 mutant alleles were found for E148Q and V726A respectively. For 2 other mutations, no mutant alleles were found. The total allelic frequency for these four common mutations was 0.132. The carriers rate was 23.4%.   Conclusion : This study showed that E148Q has high mutation frequency relative to other mutations in North-West of Iran.

  6. The Influence of Ethnic Diversity on Social Network Structure in a Common-Pool Resource System: Implications for Collaborative Management

    Directory of Open Access Journals (Sweden)

    Michele Barnes-Mauthe

    2013-03-01

    Full Text Available Social networks have recently been identified as key features in facilitating or constraining collaborative arrangements that can enhance resource governance and adaptability in complex social-ecological systems. Nonetheless, the effect of ethnicity on social network structure in an ethnically diverse common-pool resource system is virtually unknown. We characterize the entire social network of Hawaii's longline fishery, an ethnically diverse competitive pelagic fishery, and investigate network homophily, network structure, and cross-scale linkages. Results show that ethnicity significantly influences social network structure and is responsible for a homophily effect, which can create challenges for stakeholder collaboration across groups. Our analysis also suggests that ethnicity influences the formation of diverse network structures, and can affect the level of linkages to outside industry leaders, government or management officials, and members of the scientific community. This study provides the first empirical examination of the impact of ethnic diversity on resource user's social networks in the common-pool resource literature, having important implications for collaborative resource management.

  7. Monitoring human and organizational factors influencing common-cause failures of safety-instrumented system during the operational phase

    International Nuclear Information System (INIS)

    Rahimi, Maryam; Rausand, Marvin

    2013-01-01

    Safety-instrumented systems (SISs) are important safety barriers in many technical systems in the process industry. Reliability requirements for SISs are specified as a safety integrity level (SIL) with reference to the standard IEC 61508. The SIS reliability is often threatened by common-cause failures (CCFs), and the beta-factor model is the most commonly used model for incorporating the effects of CCFs. In the design phase, the beta-factor, β, is determined by answering a set of questions that is given in part 6 of IEC 61508. During the operational phase, there are several factors that influence β, such that the actual β differs from what was predicted in the design phase, and therefore the required reliability may not be maintained. Among the factors influencing β in the operational phase are human and organizational factors (HOFs). A number of studies within industries that require highly reliable products have shown that HOFs have significant influence on CCFs and therefore on β in the operational phase, but this has been neglected in the process industry. HOFs are difficult to predict, and susceptible to be changed during the operational phase. Without proper management, changing HOFs may cause the SIS reliability to drift out of its required value. The aim of this article is to highlight the importance of HOFs in estimation of β for SISs, and also to propose a framework to follow the HOFs effects and to manage them such that the reliability requirement can be maintained

  8. Genome-Wide Association Study Identifies NBS-LRR-Encoding Genes Related with Anthracnose and Common Bacterial Blight in the Common Bean.

    Science.gov (United States)

    Wu, Jing; Zhu, Jifeng; Wang, Lanfen; Wang, Shumin

    2017-01-01

    Nucleotide-binding site and leucine-rich repeat (NBS-LRR) genes represent the largest and most important disease resistance genes in plants. The genome sequence of the common bean ( Phaseolus vulgaris L.) provides valuable data for determining the genomic organization of NBS-LRR genes. However, data on the NBS-LRR genes in the common bean are limited. In total, 178 NBS-LRR-type genes and 145 partial genes (with or without a NBS) located on 11 common bean chromosomes were identified from genome sequences database. Furthermore, 30 NBS-LRR genes were classified into Toll/interleukin-1 receptor (TIR)-NBS-LRR (TNL) types, and 148 NBS-LRR genes were classified into coiled-coil (CC)-NBS-LRR (CNL) types. Moreover, the phylogenetic tree supported the division of these PvNBS genes into two obvious groups, TNL types and CNL types. We also built expression profiles of NBS genes in response to anthracnose and common bacterial blight using qRT-PCR. Finally, we detected nine disease resistance loci for anthracnose (ANT) and seven for common bacterial blight (CBB) using the developed NBS-SSR markers. Among these loci, NSSR24, NSSR73, and NSSR265 may be located at new regions for ANT resistance, while NSSR65 and NSSR260 may be located at new regions for CBB resistance. Furthermore, we validated NSSR24, NSSR65, NSSR73, NSSR260, and NSSR265 using a new natural population. Our results provide useful information regarding the function of the NBS-LRR proteins and will accelerate the functional genomics and evolutionary studies of NBS-LRR genes in food legumes. NBS-SSR markers represent a wide-reaching resource for molecular breeding in the common bean and other food legumes. Collectively, our results should be of broad interest to bean scientists and breeders.

  9. Public Awareness regarding Common Eye Diseases among Saudi Adults in Riyadh City: A Quantitative Study

    Directory of Open Access Journals (Sweden)

    Waleed A. Al Rashed

    2017-01-01

    Full Text Available Aim. The current study aimed to evaluate the knowledge of eye disease and awareness of eye care among the Saudi adults and to explore existing eye-related misconceptions in the community. Methods. A cross-sectional study was conducted in Riyadh city during May and June 2016. A self-administered anonymous online questionnaire was used to explore the most common misconceptions related to eye diseases and eye care. Results. Out of 1000 individuals, only 711 (71.1% participant responses were received. The participants’ acceptable knowledge (score ≥50% was high about the eye problem in diabetes (88.6%, ocular trauma (81.2%, and other general eye diseases (91.3%, whereas low about refractive errors (63%, pediatric eye problems (51.5%, and glaucoma (14.8%. The variation in knowledge about specific ocular morbidities was significant (p<0.001. The majority of participants reported sources of information about the common eye diseases and eye care encountered from the community, internet-based resources, and social media. Conclusions. The majority of the participants had awareness about the common eye diseases, whereas low percentage of participant’s awareness about specific condition of eye diseases. Public eye health awareness should be more focused on social media and the internet to be able to cover the younger individuals of the community.

  10. Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study.

    Science.gov (United States)

    Tijssen, Marijn J A; van Os, Jim; Wittchen, Hans-Ulrich; Lieb, Roselind; Beesdo, Katja; Mengelers, Ron; Wichers, Marieke

    2010-02-01

    Although (hypo)manic symptoms are common in adolescence, transition to adult bipolar disorder is infrequent. To examine whether the risk of transition to bipolar disorder is conditional on the extent of persistence of subthreshold affective phenotypes. In a 10-year prospective community cohort study of 3021 adolescents and young adults, the association between persistence of affective symptoms over 3 years and the 10-year clinical outcomes of incident DSM-IV (hypo)manic episodes and incident use of mental healthcare was assessed. Transition to clinical outcome was associated with persistence of symptoms in a dose-dependent manner. Around 30-40% of clinical outcomes could be traced to prior persistence of affective symptoms. In a substantial proportion of individuals, onset of clinical bipolar disorder may be seen as the poor outcome of a developmentally common and usually transitory non-clinical bipolar phenotype.

  11. Numerical analysis and experimental studies on solenoid common rail diesel injector with worn control valve

    Science.gov (United States)

    Krivtsov, S. N.; Yakimov, I. V.; Ozornin, S. P.

    2018-03-01

    A mathematical model of a solenoid common rail fuel injector was developed. Its difference from existing models is control valve wear simulation. A common rail injector of 0445110376 Series (Cummins ISf 2.8 Diesel engine) produced by Bosch Company was used as a research object. Injector parameters (fuel delivery and back leakage) were determined by calculation and experimental methods. GT-Suite model average R2 is 0.93 which means that it predicts the injection rate shape very accurately (nominal and marginal technical conditions of an injector). Numerical analysis and experimental studies showed that control valve wear increases back leakage and fuel delivery (especially at 160 MPa). The regression models for determining fuel delivery and back leakage effects on fuel pressure and energizing time were developed (for nominal and marginal technical conditions).

  12. A descriptive study of commonly used postoperative approaches to pediatric stoma care in a developing country.

    Science.gov (United States)

    Anyanwu, Lofty-John C; Mohammad, Aminu; Oyebanji, Tunde

    2013-12-01

    Construction of an enterostomy is a common procedure in pediatric surgery. However, caring for the child with a stoma is challenging for parents in developing countries. Modern devices such as colostomy bags and accessories are expensive and not readily available. The purpose of this study was to describe methods of effluent collection and peristomal skin protection used by the mothers of colostomy patients. A prospective, descriptive study was conducted between January and December 2011 during the first three postoperative outpatient clinic visits among mothers of children who had a colostomy constructed in the authors' hospital. The mothers of 44 children (27 males, 17 females, median age 3.3 months, range 2 days to 11 years) consented to participate. Demographic and clinical data were obtained from the records, and mothers were interviewed and asked to describe their preferred methods of colostomy effluent collection and peristomal skin protection. The stomas also were inspected at each clinic visit. Anorectal malformations were the most common indication for a colostomy (32, 72.73%), followed by Hirschsprung's disease (11, 25%). Forty-two (42) patients had a divided sigmoid colostomy (95.45%); two patients had a right loop transverse colostomy (4.55%). Nine mothers alternated between two different collection methods. The diaper collection method was described most frequently (22 out of 53; 41.51%), followed by wraparound waistbands (19; 35.85%) and improvised colostomy bags (12; 22.64%). Peristomal skin excoriations were commonly seen within the first 3 weeks postsurgery and had mostly disappeared by the week 6 postoperative visit. Petrolatum jelly was the most commonly used barrier ointment. These locally available, acceptable, and affordable collection methods may be useful for children in other developing countries.

  13. A Study on the Radiographic Diagnosis of Common Periapical Lesions by Using Computer

    International Nuclear Information System (INIS)

    Kim, Jae Duck; Kim, Seung Kug

    1990-01-01

    The purpose of this study was to estimate the diagnostic availability of the common periapical lesions by using computer. The author used a domestic personal computer and rearranged the applied program appropriately with RF (Rapid File), a program to answer the purpose of this study, and then input the consequence made out through collection, analysis and classification of the clinical and radiological features about the common periapical lesions as a basic data. The 256 cases (Cyst 91, Periapical granuloma 74, Periapical abscess 91) were obtained from the chart recordings and radiographs of the patients diagnosed or treated under the common periapical lesions during the past 8 years (1983-1990) at the infirmary of Dental School, Chosun University. Next, the clinical and radiographic features of the 256 cases were applied to RF program for diagnosis, and the diagnosis by using computer was compared with the hidden final diagnosis by clinical and histopathological examination. The obtained results were as follow: 1. In cases of the cyst, diagnosis through the computer program was shown rather lower accuracy (80.22%) as compared with accuracy (90.1%) by the radiologists. 2. In cases of the granuloma, diagnosis through the computer program was shown rather higher accuracy(75.7%) as compared with the accuracy (70.3%) by the radiologists. 3. In cases of periapical abscess, the diagnostic accuracy was shown 88% in both diagnoses. 4. The average diagnostic accuracy of 256 cases through the computer program was shown rather lower accuracy (81.2%) as compared with the accuracy (82.8%) by the radiologists. 5. The applied basic data for radiographic diagnosis of common periapical lesions by using computer was estimated to be available.

  14. From common to rare Zingiberaceae plants - A metabolomics study using GC-MS.

    Science.gov (United States)

    Barbosa, Gina B; Jayasinghe, Nirupama S; Natera, Siria H A; Inutan, Ellen D; Peteros, Nonita P; Roessner, Ute

    2017-08-01

    Zingiberaceae plants, commonly known as gingers, have been popular for their medicinal and culinary uses since time immemorial. In spite of their numerous health-promoting applications, many Zingiberaceae plants still receive no scientific attention. Moreover, existing reports mostly focused only on the Zingiberaceae rhizomes. Here, untargeted metabolite profiling using Gas Chromatography - Mass Spectrometry (GC-MS) was used to compare the metabolic composition of leaves and rhizomes of the more common gingers, Zingiber officinale Rosc. (ZO), Curcuma longa L. (CL), and Etlingera elatior (Jack) R.M. Smith (EE), and the rare gingers, Amomum muricarpum Elmer (AM), Etlingera philippinensis (Ridl.) R.M. Smith (EP), and Hornstedtia conoidea Ridl. (HC). Principal component analysis (PCA) demonstrated that different species show substantial chemical differentiation and revealed potential markers among the different Zingiberaceae plants. Interestingly, the leaves of AM, CL, EE, EP, and HC had significantly higher levels of chlorogenic acid than ZO. Moreover, rhizomes of EP and HC were found to contain significantly higher levels of amino acids than ZO. Sugars and organic acids were generally less abundant in ZO leaves and rhizomes than in the other gingers. The leaves of EP and rhizomes of AM were found most similar to the leaves and rhizomes of common gingers, respectively. Results of this study provide significant baseline information on assessing the possible usage of the leaves of common gingers and further propagation and exploration of EP and AM. This study, being the first metabolomics report on rare plants such as AM, EP and HC, affirms the usefulness of untargeted metabolite profiling in exploring under-investigated plants. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. A Study on the Radiographic Diagnosis of Common Periapical Lesions by Using Computer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Duck; Kim, Seung Kug [Dept. of Oral Radiology, College of Dentistry, Chosun University, Kwangju (Korea, Republic of)

    1990-08-15

    The purpose of this study was to estimate the diagnostic availability of the common periapical lesions by using computer. The author used a domestic personal computer and rearranged the applied program appropriately with RF (Rapid File), a program to answer the purpose of this study, and then input the consequence made out through collection, analysis and classification of the clinical and radiological features about the common periapical lesions as a basic data. The 256 cases (Cyst 91, Periapical granuloma 74, Periapical abscess 91) were obtained from the chart recordings and radiographs of the patients diagnosed or treated under the common periapical lesions during the past 8 years (1983-1990) at the infirmary of Dental School, Chosun University. Next, the clinical and radiographic features of the 256 cases were applied to RF program for diagnosis, and the diagnosis by using computer was compared with the hidden final diagnosis by clinical and histopathological examination. The obtained results were as follow: 1. In cases of the cyst, diagnosis through the computer program was shown rather lower accuracy (80.22%) as compared with accuracy (90.1%) by the radiologists. 2. In cases of the granuloma, diagnosis through the computer program was shown rather higher accuracy(75.7%) as compared with the accuracy (70.3%) by the radiologists. 3. In cases of periapical abscess, the diagnostic accuracy was shown 88% in both diagnoses. 4. The average diagnostic accuracy of 256 cases through the computer program was shown rather lower accuracy (81.2%) as compared with the accuracy (82.8%) by the radiologists. 5. The applied basic data for radiographic diagnosis of common periapical lesions by using computer was estimated to be available.

  16. Common floor system vertical earthquake-proof structure for reactor equipment

    International Nuclear Information System (INIS)

    Morishita, Masaki.

    1996-01-01

    In an LMFBR type reactor, a reactor container, a recycling pump and a heat exchanger are disposed on a common floor. Vertical earthquake-proof devices which can be stretched only in vertical direction formed by laminating large-sized bellevilles are disposed on a concrete wall at the circumference of each of reactor equipments. A common floor is placed on all of the vertical earthquake-proof devices to support the entire earthquake-proof structure simultaneously. If each of reactor equipments is loaded on the common floor and the common floor is entirely supported against earthquakes altogether, since the movement of each of the reactor equipments loaded on the common floor is identical, relative dislocation is not exerted on the main pipelines which connect the equipments. In addition, since the entire earthquake structure has a flat common floor and each of the reactor equipments is suspended to minimize the distance between a gravitational center and a support point, locking vibration is less caused to the horizontal earthquake. (N.H.)

  17. Common and Rare Variant Association Study for Plasma Lipids and Coronary Artery Disease.

    Science.gov (United States)

    Tada, Hayato; Kawashiri, Masa-aki; Konno, Tetsuo; Yamagishi, Masakazu; Hayashi, Kenshi

    2016-01-01

    Blood lipid levels are highly heritable and modifiable risk factors for coronary artery disease (CAD), and are the leading cause of death worldwide. These facts have motivated human genetic association studies that have the substantial potential to define the risk factors that are causal and to identify pathways and therapeutic targets for lipids and CAD.The success of the HapMap project that provided an extensive catalog of human genetic variations and the development of microarray based genotyping chips (typically containing variations with allele frequencies > 5%) facilitated common variant association study (CVAS; formerly termed genome-wide association study, GWAS) identifying disease-associated variants in a genome-wide manner. To date, 157 loci associated with blood lipids and 46 loci with CAD have been successfully identified, accounting for approximately 12%-14% of heritability for lipids and 10% of heritability for CAD. However, there is yet a major challenge termed "missing heritability problem," namely the observation that loci detected by CVAS explain only a small fraction of the inferred genetic variations. To explain such missing portions, focuses in genetic association studies have shifted from common to rare variants. However, it is challenging to apply rare variant association study (RVAS) in an unbiased manner because such variants typically lack the sufficient number to be identified statistically.In this review, we provide a current understanding of the genetic architecture mostly derived from CVAS, and several updates on the progress and limitations of RVAS for lipids and CAD.

  18. Breeding for culinary and nutritional quality of common bean (Phaseolus vulgaris L. in intercropping systems with maize (Zea mays L.

    Directory of Open Access Journals (Sweden)

    Rodino A.P.

    1999-01-01

    Full Text Available Common bean (Phaseolus vulgaris L. is widely intercropped with maize (Zea mays L. in the North of Spain. Breeding beans for multiple cropping systems is important for the development of a productive and sustainable agriculture, and is mainly oriented to minimize intercrop competition and to stabilize complementarity with maize. Most agricultural research on intercropping to date has focused on the agronomic and overall yield effects of the different species, but characters related with socio-economic and food quality aspects are also important. The effect of intercropping beans with maize on food seed quality traits was studied for thirty-five bush bean varieties under different environments in Galicia (Northwestern Spain. Parameters determining Asturian (Northern Spain white bean commercial and culinary quality have also been evaluated in fifteen accessions. There are significant differences between varieties in the selected cropping systems (sole crop, intercrop with field maize and intercrop with sweet maize for dry and soaked seed weight, coat proportion, crude protein, crude fat and moisture. Different white bean accessions have been chosen according to their culinary quality. Under these environmental conditions it appears that intercropping systems with sweet maize give higher returns than sole cropping system. It is also suggested that the culinary and nutritional quality potential of some white bean accessions could be the base material in a breeding programme the objectives of which are to develop varieties giving seeds with high food quality.

  19. Reliability and Availability Analysis of Some Systems with Common-Cause Failures Using SPICE Circuit Simulation Program

    Directory of Open Access Journals (Sweden)

    Muhammad Taher Abuelma'atti

    1999-01-01

    Full Text Available The effectiveness of SPICE circuit simulation program in calculating probabilities, reliability, steady-state availability and mean-time to failure of repairable systems described by Markov models is demonstrated. Two examples are presented. The first example is a warm standby system with common-cause failures and human errors. The second example is a non-identical unit parallel system with common-cause failures. In both cases recourse to numerical solution is inevitable to obtain the Laplace transforms of the probabilities. Results obtained using SPICE are compared with previously published results obtained using the Laplace transform method. Full SPICE listings are included.

  20. Rangeland Use Rights Privatisation Based on the Tragedy of the Commons: A Case Study from Tibet

    Directory of Open Access Journals (Sweden)

    Yonten Nyima Yundannima

    2017-01-01

    Full Text Available Rangeland use rights privatisation based on a tragedy of the commons assumption has been the backbone of state policy on rangeland management and pastoralism in China. Through an empirical case study from Pelgon county, Tibet Autonomous Region in China, this paper provides an empirical analysis of rangeland use rights privatisation. It shows that the tragedy of the commons is not the correct model to apply to Tibetan pastoralism because pasture use in Tibet has never been an open-access institution. Thus, when the tragedy of the commons model is applied as a rationale for rangeland use rights privatisation, the result is not what is intended by the policy, but rather a misfit to features of pastoralism and thus disruption of the essence of pastoralism, i.e. mobility and flexibility. The paper further shows that a hybrid institution combining household rangeland tenure with community-based use with user fees is a restoration of the pastoralist institution. This demonstrates the capacity of pastoralists to create adaptive new institutions congruent with the interdependent and integrated nature of pastoralism consisting of three components: pastoralists, livestock, and rangeland.

  1. Nutritional composition of the commonly consumed composite dishes for the Barbados National Cancer Study.

    Science.gov (United States)

    Sharma, Sangita; Harris, Rachel; Cao, Xia; Hennis, Anselm J M; Leske, M Cristina; Wu, Suh-Yuh

    2007-09-01

    To provide, for the first time, the calculated nutritional composition of 32 composite dishes commonly consumed in Barbados to enable dietary intake to be calculated from a Quantitative Food Frequency Questionnaire developed specifically for this population to determine associations between diet and risk of prostate and breast cancer. Weighed recipes were collected in up to six different households for each of the 32 composite dishes. The average nutritional composition for these composite dishes was calculated using the US Department of Agriculture National Nutrient Database. One hundred and fifty-two weighed recipes were collected for 32 composite dishes: five were fish based, two were ground beef dishes, two were chicken based, two were offal based, two were lamb dishes, one was pork based, three were rice based, three were commonly consumed home-made drinks, and the remaining were miscellaneous items. A total of 152 weighed recipes were collected and we provide, for the first time, nutritional composition data for 32 commonly consumed food and drink items in Barbados. Such data are essential for assessing nutrient intake and determining associations between diet and prostate and breast cancer in the Barbados National Cancer Study.

  2. An experimental microangiographic study on injured liver acinus by ligation of common bile duct

    International Nuclear Information System (INIS)

    Park, Jong Yeon; Kim, Yoon Gyu; Moon, Ki Ho; Lee, Suek Hong; Kim, Byung Soo; Han, Gun Taik

    1994-01-01

    The purpose of this study was to evaluate the morphologic changes of the injured hepatic acini following ligation of common bile duct and to investigate the pathophysiologic process of hepatic failure and biliary liver cirrhosis in the extrahepatic cholestasis. The common bile ducts of 18 rabbits were ligated partially. The rabbits were killed and selective microangiography was carried out with infusion of barium suspensio via portal vein 4 to 24 weeks after ligation. Selective microangiography was also carried out in two normal rabbits. The microangiographic findings were evaluated and correlated with histopathologic features. The sinusoids of the liver acinus showed distortion, varying degrees of luminal widening, and irregularities in architecture. Terminal branches of the portal vein (TPV) showed increased number of branches, luminal narrowing, tortuosity, distortion, and beaded appearance. Peribiliary plexi were found as thin curvilinear, barium-filled structures along the wall of the dilated bile duct. The microangiographic findings were well correlated with histopathologic findings. The grades of microangiographic and histopathologic findings were poorly correlated with the duration of the ligation of CBD. Changes in microvasculature of the liver scinus following partial ligation of common bile duct were demonstrated by microangiography. Although the microvascular changes were evoked secondary to the injury, they might have some active roles in the pathophysiologic process in the liver

  3. A study of institutional origins and change in a Canadian urban commons

    Directory of Open Access Journals (Sweden)

    James P. Robson

    2015-09-01

    Full Text Available Kenora is a small city located in northwestern Ontario, Canada. The study presented here focuses on Tunnel Island, 300 acres of forested land adjacent to Kenora’s downtown. The island is used and valued by both city residents and members of three nearby Ojibway nations. As a multiple-use, common-pool resource accessed by different groups for a range of non-extractive activities, the site has become an experiment in multicultural commons governance, and presents an excellent opportunity to examine the origins and development of institutions for managing collective environmental resources in an urban setting. Using participant observation, internet- and field-based user surveys, and semi-structured interviews, our research finds that grassroots ‘governance’ of the site is emerging through subtle processes of individual and social construction, with the strategies and norms (codes of conduct employed by users providing relative harmony on the trails, which suggests functioning commons institutions. Nevertheless, values-based and epistemic tensions exist among users, pointing to governance challenges for planned joint management of the site, and specifically the need to develop formal, legitimate, and yet flexible and inclusive arrangements that can operate in conjunction with the social practice of existing users.

  4. Common symptoms of Nepalese soft contact lens wearers: A pilot study.

    Science.gov (United States)

    Sapkota, Kishor; Martin, Raul; Franco, Sandra; Lira, Madalena

    2015-01-01

    To determine the common symptoms in current soft contact lens (CL) wearers and their association with other factors among Nepalese population. All the current CL wearers who started to wear soft CL in Nepal Eye Hospital between July 2007 and June 2012 were invited for the participation. Frequency of the ten most common symptoms, divided into never, occasionally, frequently and consistent were recorded. Association between degree of symptoms with other factors, e.g. age, gender, profession, cigarette smoking, ethnicity, level of education and duration and wearing modality of CL wear were analyzed. Out of 129 subjects participated in this study, 67% were female; the mean age of the subjects was 23.9±4.3 years. Ninety seven percent of them had at least one symptom occasionally or frequently or consistently. Discomfort was found in 88.4% of the total subjects. Other common symptoms were foreign body sensation in 73.6%, redness in 65.9%, reduced wearing time in 63.6% and dryness in 62.8%. Symptoms were found occasionally in the majority of subjects. Degree of symptoms was not associated with age, gender, profession, education status, ethnicity of subjects and duration or modality of lens wear (p>0.05) but was positively associated with passive cigarette smoking (p<0.001). Almost all of the Nepalese soft CL wearers had some types of symptoms at least occasionally. Discomfort was the most common symptom. Degree of symptoms was associated with the passive smoking but not with other factors like age, sex, profession and duration of lens wear. Copyright © 2014 Spanish General Council of Optometry. Published by Elsevier Espana. All rights reserved.

  5. STUDY OF THE ADAPTATION PROCESS IN COMMON CARP (CYPRINUS CARPIO L. AFTER HARVESTING

    Directory of Open Access Journals (Sweden)

    Milena Bušová

    2013-02-01

    Full Text Available Fish is sensitive to exogenous and endogenous ammonia. Ammonia formed in fish as a product of metabolism of proteins may be under certain circumstances life-threatening. Ammonia autointoxication is a serious problem and can cause mass mortalities in fish farms. This study focused on the common carp Cyprinus carpio L. in large-capacity breeding farms. It was focused on monitoring the blood ammonia levels in fish blood in the period of metabolic attenuation and the influence of harvesting and handling of fish on the fish's ability to withstand such changes. The study results confirmed the effect of sudden changes in water temperature to values of ammonia in the blood of fish. On the contrary, there were no dramatically increased concentrations of ammonia in the blood of fish nor symptoms of autointoxication. The measured ammonia concentrations ranged between 98.3 ± 56µmol/L and 141.4 ± 31 µmol/L in the monitored period, which corresponds with the study results of other authors. This study has confirmed good technological conditions in the market production of carp after harvesting and a good level of adaptation process of the common carp Cyprinus carpio L. to these changes.

  6. A common framework for greenhouse gas assessment protocols in temperate agroforestry systems: Connecting via GRACEnet

    Science.gov (United States)

    Agroforestry systems offer many ecosystem benefits, but such systems have previously been marginalized in temperate environments due to overriding economic goals and perceived management complexity. In view of adaptation to a changing climate, agroforestry systems offer advantages that require quan...

  7. Common rail fuel injection system for improvement of engine performance and reduction of exhaust emission on heavy duty diesel engine; Common rail system ni yoru seino haishutsu gas no kaizen

    Energy Technology Data Exchange (ETDEWEB)

    Kato, T; Koyama, T; Sasaki, K; Mori, K; Mori, K [Mitsubishi Motor Corp., Tokyo (Japan)

    1997-10-01

    With the objective of improvement of engine performance and reduction of exhaust emissions, influence of control method to decrease initial injection rate and effect of injector types on fuel leakage of common rail fuel injection system (Common Rail System) were investigated. As a results, it became clear that injector with 2-way valve brings improvement of engine performance and reduction of exhaust emissions as compared with injector with 3-way valve because injector with 2-way valve has lower fuel leakage and is able to use higher injection pressure than injector with 3-way valve. 5 refs., 13 figs., 1 tab.

  8. Orbital Noise in the Earth System is a Common Cause of Climate and Greenhouse-Gas Fluctuation

    Science.gov (United States)

    Liu, H. S.; Kolenkiewicz, R.; Wade, C., Jr.; Smith, David E. (Technical Monitor)

    2002-01-01

    The mismatch between fossil isotopic data and climate models known as the cool-tropic paradox implies that either the data are flawed or we understand very little about the climate models of greenhouse warming. Here we question the validity of the climate models on the scientific background of orbital noise in the Earth system. Our study shows that the insolation pulsation induced by orbital noise is the common cause of climate change and atmospheric concentrations of carbon dioxide and methane. In addition, we find that the intensity of the insolation pulses is dependent on the latitude of the Earth. Thus, orbital noise is the key to understanding the troubling paradox in climate models.

  9. Common variant of ALPK1 is not associated with gout: a replication study

    OpenAIRE

    Chiba, Toshinori; Matsuo, Hirotaka; Sakiyama, Masayuki; Nakayama, Akiyoshi; Shimizu, Seiko; Wakai, Kenji; Suma, Shino; Nakashima, Hiroshi; Sakurai, Yutaka; Shimizu, Toru; Ichida, Kimiyoshi; Shinomiya, Nariyoshi

    2014-01-01

    Gout is one of the most kinds of common inflammatory arthritis as a consequence of hyperuricemia. Alpha-protein kinase 1 (ALPK1) gene locates in a gout-susceptibility locus on chromosome 4q21?31, and encodes ALPK1 protein which plays a pivotal role in the phosphorylation of myosin 1. In the previous genetic study of Taiwanese populations, 3 single nucleotide polymorphisms (SNPs), rs11726117, rs231247 and rs231253, in ALPK1 gene were reported to have a significant association with gout. Howeve...

  10. Phylogenetic Analysis Reveals Common Antimicrobial Resistant Campylobacter coli Population in Antimicrobial-Free (ABF) and Commercial Swine Systems

    Science.gov (United States)

    Quintana-Hayashi, Macarena P.; Thakur, Siddhartha

    2012-01-01

    The objective of this study was to compare the population biology of antimicrobial resistant (AR) Campylobacter coli isolated from swine reared in the conventional and antimicrobial-free (ABF) swine production systems at farm, slaughter and environment. A total of 200 C. coli isolates selected from fecal, environmental, and carcass samples of ABF (n = 100) and conventional (n = 100) swine production systems were typed by multilocus sequence typing (MLST). Sequence data from seven housekeeping genes was analyzed for the identification of allelic profiles, sequence types (STs) and clonal complex determination. Phylogenetic trees were generated to establish the relationships between the genotyped isolates. A total of 51 STs were detected including two novel alleles (glnA 424 and glyA 464) and 14 novel STs reported for the first time. The majority of the C. coli isolates belonged to ST-854 (ABF: 31, conventional: 17), and were grouped in clonal complex ST-828 (ABF: 68%, conventional: 66%). The mean genetic diversity (H) for the ABF (0.3963+/−0.0806) and conventional (0.4655+/−0.0714) systems were similar. The index of association () for the ABF ( = 0.1513) and conventional ( = 0.0991) C. coli populations were close to linkage equilibrium, indicative of a freely recombining population. Identical STs were detected between the pigs and their environment both at farm and slaughter. A minimum spanning tree revealed the close clustering of C. coli STs that originated from swine and carcass with those from the environment. In conclusion, our study reveals a genotypic diverse C. coli population that shares a common ancestry in the conventional and ABF swine production systems. This could potentially explain the high prevalence of antimicrobial resistant C. coli in the ABF system in the absence of antimicrobial selection pressure. PMID:22984540

  11. Study on clearance system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-15

    The clearance system is a legal system to release 'the radioactive waste not requiring treatment as radioactive waste' from the regulatory control. JNES supports Nuclear Regulatory Agency on approval and confirmation of clearance measurement and judgment developed by the operator. The objective of this study is to establish technical base of the validation method of the clearance measurement for various objects. In uranium processing facilities, simulation sources emitting alpha-rays is used in a validity confirmation examination of the measuring equipment. In this study, these sources were examined by measuring alpha and beta spectra to evaluate the applicability and problem of these sources. In addition, the measuring method detecting gamma-rays was examined. This method can be applied to complicated objects. As a part to develop a manual for unexpected incidents in clearance system, a quick method for measurement of Strontium 90 was examined. In addition, the measuring methods for the judgment of the influence of fallout and for NR (Non-Radioactive) confirmation were examined. (author)

  12. Study on clearance system

    International Nuclear Information System (INIS)

    Onishi, Yuko; Miura, Hiroshi; Kawasaki, Satoru

    2011-01-01

    The clearance system is a legal system to release 'the radioactive waste not requiring treatment as radioactive waste' from the regulatory control. JNES supports NISA on approval and confirmation of clearance measurement and judgment developed by the operator. The objective of this study is to establish technical base of the validation method of the clearance measurement for various objects. In reactor facilities, the bulk measurement technique or the statistical sampling measurement technique may be applied to large scale objects or concrete walls. In this study, the criteria of those techniques were examined. In uranium processing facilities, it is important to confirm surface state of the object in case of detecting alpha rays. The result of the examination about the influence of the surface rust in the uranium clearance measurement by the alpha ray measurement showed that the pollution was distributed in rust layer uniformly. This result will be reflected to the revision of the Ministerial Ordinance on Clearance in 2011FY. To develop a manual for unexpected incidents, the response procedure for an unexpected incident was prepared, including a response system. (author)

  13. Common and specific liability to addiction: approaches to association studies of opioid addiction.

    Science.gov (United States)

    Nielsen, David A; Kreek, Mary Jeanne

    2012-06-01

    Opioid addiction, whether to opiates such as heroin and morphine, and/or to non-medical use of opioids, is a major problem worldwide. Although drug-induced and environmental factors are essential for the liability to develop opioid addiction, the genetic background of an individual is now known also to play a substantial role. The overall goal of this article is to address the common and specific liabilities to addiction in the context of approaches to studies of one addiction, opioid addiction. Literature on identifying genetic variants that may play a role in the development of opioid addiction was reviewed. A substantial number of genetic variants have been reported to be associated with opioid addiction. No single variant has been found in any of the reported GWAS studies with a substantial effect size on the liability to develop heroin addiction. It appears that there is a complex interaction of a large number of variants, some rare, some common, which interact with the environment and in response to specific drugs of abuse to increase the liability of developing opioid addiction. In spite of the inherent difficulties in obtaining large well-phenotyped cohorts for genetic studies, new findings have been reported that are being used to develop testable hypotheses into the biological basis of opioid addiction. Copyright © 2012. Published by Elsevier Ireland Ltd.

  14. Sensitivity study of state-of-the-art common cause failure analysis

    International Nuclear Information System (INIS)

    Guey, Ching

    2004-01-01

    Common cause failures (CCFs) have been touted as one of the major contributors of plant risk due to its pervasive nature and somewhat conservative approaches taken in most Probabilistic Risk Assessment (PRA) studies. The objectives of this study are twofold: First, to gain a better understanding on the impact of various CCF failure probability on the overall plant risk. Secondly, to appreciate the state-of-the-art CCF modelling and data limitations for applications to a full-scale plant risk assessment. The sensitivity study of varying the CCF parameters for different cases indicates that CCF data differences based on the various cases commonly adopted in the PRAs yield core damage frequency variations between 8.5% to -25.6% of the baseline case. It appears that only if CCFs are guaranteed to occur, the core damage frequency would change significantly, by approximately a factor of 5. This suggests that prevention of CCFs is more important than dwelling on the analytical differences in the finer interpretation of the operating experience to develop the CCF parameters. (author)

  15. Challenges and opportunities in coding the commons: problems, procedures, and potential solutions in large-N comparative case studies

    Directory of Open Access Journals (Sweden)

    Elicia Ratajczyk

    2016-09-01

    Full Text Available On-going efforts to understand the dynamics of coupled social-ecological (or more broadly, coupled infrastructure systems and common pool resources have led to the generation of numerous datasets based on a large number of case studies. This data has facilitated the identification of important factors and fundamental principles which increase our understanding of such complex systems. However, the data at our disposal are often not easily comparable, have limited scope and scale, and are based on disparate underlying frameworks inhibiting synthesis, meta-analysis, and the validation of findings. Research efforts are further hampered when case inclusion criteria, variable definitions, coding schema, and inter-coder reliability testing are not made explicit in the presentation of research and shared among the research community. This paper first outlines challenges experienced by researchers engaged in a large-scale coding project; then highlights valuable lessons learned; and finally discusses opportunities for further research on comparative case study analysis focusing on social-ecological systems and common pool resources.

  16. Assessment of yeast as a dietary additive on haematology and water quality of common carp in a recirculating aquaculture system

    Science.gov (United States)

    Goran, Siraj Muhammed Abdulla; Omar, Samad Sofy; Anwer, Ayub Youns

    2017-09-01

    Feeding experiment was accomplished at the Aquaculture unit (Close system), Grdarasha station, Agriculture College, University of Salahaddin, Erbil, Kurdistan Region, to investigate different levels of Aquagrow E (AGEY) brewer's yeast cell Saccharomyces cerevisiae on the haematological and water quality of common carp fingerlings Cyprinus carpio. The basal diet was formulated to contain 34% protein and 10% lipid and the dietary treatments were supplemented with 0.5%, 1% and 1.5% of AGEY diet. A total of 180 Common carp (10.30 ± 0.27 g) fed on experimental diets for 10 weeks. Water quality assessment for well water and pond water for rearing Cyprinus carpio in cage system conducted weekly, while some parameters including pH, EC, water temperature and DO were monitored daily during the entire periods of study. Values of total hardness, alkalinity, ammonia and nitrate for studied water samples were within normal ranges for rearing Cyprinus carpio. Mean concentration of GPT, GOT and Glucose were 104 to 170 U/L, 1371 to 3308 U/L and 34 to 63mg/dl respectively, moreover, highest levels were observed in treatments with higher concentrations of yeast in its food except for blood sugar. Slight variation in lipase enzyme were found between control and treatment groups, while levels of amylase enzyme were increased toward cages with higher levels of yeast until T1 and then decreased toward T3. Total protein levels were increased to toward higher levels of yeast in food of Cyprinus carpio fish. Haematological results showed highest levels of WBC and platelets in treatments cages than control group. Levels of RBCs and hemoglobin were highest in treatment group 1 with 0.5%of yeast than treatments higher yeast concentrations. Significant correlation was found in haematological parameters between control and treatments.

  17. Hydrogen energy systems studies

    Energy Technology Data Exchange (ETDEWEB)

    Ogden, J.M.; Steinbugler, M.; Dennis, E. [Princeton Univ., NJ (United States)] [and others

    1995-09-01

    For several years, researchers at Princeton University`s Center for Energy and Environmental Studies have carried out technical and economic assessments of hydrogen energy systems. Initially, we focussed on the long term potential of renewable hydrogen. More recently we have explored how a transition to renewable hydrogen might begin. The goal of our current work is to identify promising strategies leading from near term hydrogen markets and technologies toward eventual large scale use of renewable hydrogen as an energy carrier. Our approach has been to assess the entire hydrogen energy system from production through end-use considering technical performance, economics, infrastructure and environmental issues. This work is part of the systems analysis activity of the DOE Hydrogen Program. In this paper we first summarize the results of three tasks which were completed during the past year under NREL Contract No. XR-11265-2: in Task 1, we carried out assessments of near term options for supplying hydrogen transportation fuel from natural gas; in Task 2, we assessed the feasibility of using the existing natural gas system with hydrogen and hydrogen blends; and in Task 3, we carried out a study of PEM fuel cells for residential cogeneration applications, a market which might have less stringent cost requirements than transportation. We then give preliminary results for two other tasks which are ongoing under DOE Contract No. DE-FG04-94AL85803: In Task 1 we are assessing the technical options for low cost small scale production of hydrogen from natural gas, considering (a) steam reforming, (b) partial oxidation and (c) autothermal reforming, and in Task 2 we are assessing potential markets for hydrogen in Southern California.

  18. Systems biology elucidates common pathogenic mechanisms between nonalcoholic and alcoholic-fatty liver disease.

    Directory of Open Access Journals (Sweden)

    Silvia Sookoian

    Full Text Available The abnormal accumulation of fat in the liver is often related either to metabolic risk factors associated with metabolic syndrome in the absence of alcohol consumption (nonalcoholic fatty liver disease, NAFLD or to chronic alcohol consumption (alcoholic fatty liver disease, AFLD. Clinical and histological studies suggest that NAFLD and AFLD share pathogenic mechanisms. Nevertheless, current data are still inconclusive as to whether the underlying biological process and disease pathways of NAFLD and AFLD are alike. Our primary aim was to integrate omics and physiological data to answer the question of whether NAFLD and AFLD share molecular processes that lead to disease development. We also explored the extent to which insulin resistance (IR is a distinctive feature of NAFLD. To answer these questions, we used systems biology approaches, such as gene enrichment analysis, protein-protein interaction networks, and gene prioritization, based on multi-level data extracted by computational data mining. We observed that the leading disease pathways associated with NAFLD did not significantly differ from those of AFLD. However, systems biology revealed the importance of each molecular process behind each of the two diseases, and dissected distinctive molecular NAFLD and AFLD-signatures. Comparative co-analysis of NAFLD and AFLD clarified the participation of NAFLD, but not AFLD, in cardiovascular disease, and showed that insulin signaling is impaired in fatty liver regardless of the noxa, but the putative regulatory mechanisms associated with NAFLD seem to encompass a complex network of genes and proteins, plausible of epigenetic modifications. Gene prioritization showed a cancer-related functional map that suggests that the fatty transformation of the liver tissue is regardless of the cause, an emerging mechanism of ubiquitous oncogenic activation. In conclusion, similar underlying disease mechanisms lead to NAFLD and AFLD, but specific ones depict a

  19. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB

    Science.gov (United States)

    Need, Anna C.; Attix, Deborah K.; McEvoy, Jill M.; Cirulli, Elizabeth T.; Linney, Kristen L.; Hunt, Priscilla; Ge, Dongliang; Heinzen, Erin L.; Maia, Jessica M.; Shianna, Kevin V.; Weale, Michael E.; Cherkas, Lynn F.; Clement, Gail; Spector, Tim D.; Gibson, Greg; Goldstein, David B.

    2009-01-01

    Psychiatric disorders such as schizophrenia are commonly accompanied by cognitive impairments that are treatment resistant and crucial to functional outcome. There has been great interest in studying cognitive measures as endophenotypes for psychiatric disorders, with the hope that their genetic basis will be clearer. To investigate this, we performed a genome-wide association study involving 11 cognitive phenotypes from the Cambridge Neuropsychological Test Automated Battery. We showed these measures to be heritable by comparing the correlation in 100 monozygotic and 100 dizygotic twin pairs. The full battery was tested in ∼750 subjects, and for spatial and verbal recognition memory, we investigated a further 500 individuals to search for smaller genetic effects. We were unable to find any genome-wide significant associations with either SNPs or common copy number variants. Nor could we formally replicate any polymorphism that has been previously associated with cognition, although we found a weak signal of lower than expected P-values for variants in a set of 10 candidate genes. We additionally investigated SNPs in genomic loci that have been shown to harbor rare variants that associate with neuropsychiatric disorders, to see if they showed any suggestion of association when considered as a separate set. Only NRXN1 showed evidence of significant association with cognition. These results suggest that common genetic variation does not strongly influence cognition in healthy subjects and that cognitive measures do not represent a more tractable genetic trait than clinical endpoints such as schizophrenia. We discuss a possible role for rare variation in cognitive genomics. PMID:19734545

  20. Postoperative follow-up studies in congenital dilatation of the common bile duct using hepatobiliary scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Hirobe, Seiichi; Ishida, Haruo; Hayashi, Akira; Kamagata, Shoichiro; Fuchimoto, Yasufumi; Mizuno, Dai; Yano, Tsunehiro [Tokyo Metropolitan Kiyose Children`s Hospital (Japan); Ishii, Katsumi

    1995-03-01

    Follow-up studies in congenital dilatation of the common bile duct were done in 20 cases ranging 3 to 20 years after operation. Operative cholangiography had shown dilatation of the intrahepatic bile ducts in 15 patients (75%), of these, 7 patients had cystic dilatation. Five cases of these 7 patients showed prolonged stasis of the nuclide in the cystic dilated intrahepatic bile ducts by {sup 99m}Tc-PMT hepatobiliary scintigraphy in the follow-up studies even at 10 years after operation. But none of 20 cases had complication such as intrahepatic lithiasis, cholangitis, and liver dysfunction. Hepatobiliary scintigraphy could provide moderate anatomic and excellent functional information which were useful for these follow-up studies and careful follow-up should be done in the case of cystic dilatation of the intrahepatic bile ducts. (author).

  1. Application of a New Dynamic Heating System Model Using a Range of Common Control Strategies

    Directory of Open Access Journals (Sweden)

    Joshua Fong

    2016-06-01

    Full Text Available This research investigates the overall heating energy consumptions using various control strategies, secondary heat emitters, and primary plant for a building. Previous research has successfully demonstrated that a dynamic distributed heat emitter model embedded within a simplified third-order lumped parameter building model is capable of achieving improved results when compared to other commercially available modelling tools. With the enhanced ability to capture transient effects of emitter thermal capacity, this research studies the influence of control strategies and primary plant configurations on the rate of energy consumption of a heating system. Four alternative control strategies are investigated: zone feedback; weather-compensated; a combination of both of these methods; and thermostatic control. The plant alternative configurations consist of conventional boilers, biomass boilers, and heat pumps supporting radiator heating and underfloor heating. The performance of the model is tested on a primary school building and can be applied to any residential or commercial building with a heating system. Results show that the new methods reported offer greater detail and rigor in the conduct of building energy modelling.

  2. Impact of physical properties of biodiesel on the injection process in a common-rail direct injection system

    International Nuclear Information System (INIS)

    Boudy, Frederic; Seers, Patrice

    2009-01-01

    This paper presents the influence of biodiesel fuel properties on the injection mass flow rate of a diesel common-rail injection system. Simulations are first performed with ISO 4113 diesel fuel on a four-cylinder common-rail system to evaluate a single and triple injection strategies. For each injection strategy, the impact of modifying a single fuel property at a time is evaluated so as to quantify its influence on the injection process. The results show that fuel density is the main property that affects the injection process, such as total mass injected and pressure wave in the common-rail system. The fuel's viscosity and bulk modulus also influence, but to a lessen degree, the mass flow rate of the injector notably during multiple injection strategies as individual properties change the fuel's dampening property and friction coefficient.

  3. Nonlinear Parameter Estimation in Microbiological Degradation Systems and Statistic Test for Common Estimation

    DEFF Research Database (Denmark)

    Sommer, Helle Mølgaard; Holst, Helle; Spliid, Henrik

    1995-01-01

    Three identical microbiological experiments were carried out and analysed in order to examine the variability of the parameter estimates. The microbiological system consisted of a substrate (toluene) and a biomass (pure culture) mixed together in an aquifer medium. The degradation of the substrate...... and the growth of the biomass are described by the Monod model consisting of two nonlinear coupled first-order differential equations. The objective of this study was to estimate the kinetic parameters in the Monod model and to test whether the parameters from the three identical experiments have the same values....... Estimation of the parameters was obtained using an iterative maximum likelihood method and the test used was an approximative likelihood ratio test. The test showed that the three sets of parameters were identical only on a 4% alpha level....

  4. A Comparison of the American Common Core State Standards with the Finnish Educational System

    Science.gov (United States)

    Lynch, Kelly

    2014-01-01

    With the failure of the No Child Left Behind policies of the 1990's, educational reformers wished to establish a "new and improved" set of standards for the United States to follow. However, since their inception in 2006-2007, the new Common Core State Standards have become increasingly unpopular due to the fact that they remain largely…

  5. A DAB Converter with Common-Point-Connected Winding Transformers Suitable for a Single-Phase 5-Level SST System

    Directory of Open Access Journals (Sweden)

    Hyeok-Jin Yun

    2018-04-01

    Full Text Available One of the main disadvantages of the multi-level solid-state transformer (SST system is the voltage imbalance on the output of the rectifier modules. This voltage imbalance can be caused by parameter mismatch of the active and passive components, different loads, and the floating structure of the high voltage DC-links. Some studies have been done to solve this voltage imbalance problem. A common way to avoid this imbalance is to balance the voltage of DC-links at the AC/DC conversion stage and balance the power between the modules at the DC/DC conversion stage. Most of these methods require a complex balancing controller or additional circuits. This paper proposes a novel dual active bridge (DAB converter specialized in power balancing in a single-phase 5-level SST system. The proposed DAB converter does not require any additional balancing controllers or techniques for power balancing. The performance of the proposed DAB converter was verified by simulation and experiments using a 3 kW 5-level SST prototype system.

  6. A common thread in unconventional superconductivity. The functional renormalization group in multi-band systems

    International Nuclear Information System (INIS)

    Platt, Christian

    2012-01-01

    The superconducting properties of complex materials like the recently discovered iron-pnictides or strontium-ruthenate are often governed by multi-orbital effects. In order to unravel the superconductivity of those materials, we develop a multi-orbital implementation of the functional renormalization group and study the pairing states of several characteristic material systems. Starting with the iron-pnictides, we find competing spin-fluctuation channels that become attractive if the superconducting gap changes sign between the nested portions of the Fermi surface. Depending on material details like doping or pnictogen height, these spin fluctuations then give rise to s ± -wave pairing with or without gap nodes and, in some cases, also change the symmetry to d-wave. Near the transition from nodal s ± -wave to d-wave pairing, we predict the occurrence of a time-reversal symmetry-broken (s+id)-pairing state which avoids gap nodes and is therefore energetically favored. We further study the electronic instabilities of doped graphene, another fascinating material which has recently become accessible and which can effectively be regarded as multi-orbital system. Here, the hexagonal lattice structure assures the degeneracy of two d-wave pairing channels, and the system then realizes a chiral (d+id)-pairing state in a wide doping range around van-Hove filling. In addition, we also find spin-triplet pairing as well as an exotic spin-density wave phase which both become leading if the long-ranged hopping or interaction parameters are slightly modified, for example, by choosing different substrate materials. Finally, we consider the superconducting state of strontium-ruthenate, a possible candidate for chiral spin-triplet pairing with fascinating properties like the existence of half-quantum vortices obeying non-Abelian statistics. Using a microscopic three orbital description including spin-orbit coupling, we demonstrate that ferromagnetic fluctuations are still

  7. Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in Sprague-Dawley rats.

    Directory of Open Access Journals (Sweden)

    Yudong D He

    Full Text Available Gene expression profiling is a tool to gain mechanistic understanding of adverse effects in response to compound exposure. However, little is known about how the common handling procedures of experimental animals during a preclinical study alter baseline gene expression. We report gene expression changes in the livers of female Sprague-Dawley rats following common handling procedures. Baseline gene expression changes identified in this study provide insight on how these changes may affect interpretation of gene expression profiles following compound exposure. Rats were divided into three groups. One group was not subjected to handling procedures and served as controls for both handled groups. Animals in the other two groups were weighed, subjected to restraint in Broome restrainers, and administered water via oral gavage daily for 1 or 4 days with tail vein blood collections at 1, 2, 4, and 8 hours postdose on days 1 and 4. Significantly altered genes were identified in livers of animals following 1 or 4 days of handling when compared to the unhandled animals. Gene changes in animals handled for 4 days were similar to those handled for 1 day, suggesting a lack of habituation. The altered genes were primarily immune function related genes. These findings, along with a correlating increase in corticosterone levels suggest that common handling procedures may cause a minor immune system perturbance.

  8. Evaluation of seven common lipid associated loci in a large Indian sib pair study.

    Science.gov (United States)

    Rafiq, Sajjad; Venkata, Kranthi Kumar M; Gupta, Vipin; Vinay, D G; Spurgeon, Charles J; Parameshwaran, Smitha; Madana, Sandeep N; Kinra, Sanjay; Bowen, Liza; Timpson, Nicholas J; Smith, George Davey; Dudbridge, Frank; Prabhakaran, Dorairaj; Ben-Shlomo, Yoav; Reddy, K Srinath; Ebrahim, Shah; Chandak, Giriraj R

    2012-11-14

    Genome wide association studies (GWAS), mostly in Europeans have identified several common variants as associated with key lipid traits. Replication of these genetic effects in South Asian populations is important since it would suggest wider relevance for these findings. Given the rising prevalence of metabolic disorders and heart disease in the Indian sub-continent, these studies could be of future clinical relevance. We studied seven common variants associated with a variety of lipid traits in previous GWASs. The study sample comprised of 3178 sib-pairs recruited as participants for the Indian Migration Study (IMS). Associations with various lipid parameters and quantitative traits were analyzed using the Fulker genetic association model. We replicated five of the 7 main effect associations with p-values ranging from 0.03 to 1.97x10(-7). We identified particularly strong association signals at rs662799 in APOA5 (beta=0.18 s.d, p=1.97 x 10(-7)), rs10503669 in LPL (beta =-0.18 s.d, p=1.0 x 10(-4)) and rs780094 in GCKR (beta=0.11 s.d, p=0.001) loci in relation to triglycerides. In addition, the GCKR variant was also associated with total cholesterol (beta=0.11 s.d, p=3.9x10(-4)). We also replicated the association of rs562338 in APOB (p=0.03) and rs4775041 in LIPC (p=0.007) with LDL-cholesterol and HDL-cholesterol respectively. We report associations of five loci with various lipid traits with the effect size consistent with the same reported in Europeans. These results indicate an overlap of genetic effects pertaining to lipid traits across the European and Indian populations.

  9. Critical appraisal of nonrandomized studies-A review of recommended and commonly used tools.

    Science.gov (United States)

    Quigley, Joan M; Thompson, Juliette C; Halfpenny, Nicholas J; Scott, David A

    2018-02-27

    When randomized controlled trial data are limited or unavailable, or to supplement randomized controlled trial evidence, health technology assessment (HTA) agencies may rely on systematic reviews of nonrandomized studies (NRSs) for evidence of the effectiveness of health care interventions. NRS designs may introduce considerable bias into systematic reviews, and several methodologies by which to evaluate this risk of bias are available. This study aimed to identify tools commonly used to assess bias in NRS and determine those recommended by HTA bodies. Appraisal tools used in NRS were identified through a targeted search of systematic reviews (January 2013-March 2017; MEDLINE and EMBASE [OVID SP]). Recommendations for the critical appraisal of NRS by expert review groups and HTA bodies were reviewed. From the 686 studies included in the narrative synthesis, 48 critical appraisal tools were identified. Commonly used tools included the Newcastle-Ottawa Scale, the methodological index for NRS, and bespoke appraisal tools. Neither the Cochrane Handbook nor the Centre for Reviews and Dissemination recommends a particular instrument for the assessment of risk of bias in NRS, although Cochrane has recently developed their own NRS critical appraisal tool. Among HTA bodies, only the Canadian Agency for Drugs and Technologies in Health recommends use of a specific critical appraisal tool-SIGN 50 (for cohort or case-control studies). Several criteria including reporting, external validity, confounding, and power were examined. There is no consensus between HTA groups on the preferred appraisal tool. Reviewers should select from a suite of tools on the basis of the design of studies included in their review. © 2018 John Wiley & Sons, Ltd.

  10. Common mental disorders and associated factors: a study of women from a rural area.

    Science.gov (United States)

    Parreira, Bibiane Dias Miranda; Goulart, Bethania Ferreira; Haas, Vanderlei José; Silva, Sueli Riul da; Monteiro, Juliana Cristina Dos Santos; Gomes-Sponholz, Flávia Azevedo; Parreira, Bibiane Dias Miranda; Goulart, Bethania Ferreira; Haas, Vanderlei José; Silva, Sueli Riul da; Monteiro, Juliana Cristina Dos Santos; Gomes-Sponholz, Flávia Azevedo

    2017-05-25

    Identifying the prevalence of Common Mental Disorders and analyzing the influence of sociodemographic, economic, behavioral and reproductive health variables on Common Mental Disorders in women of childbearing age living in the rural area of Uberaba-MG, Brazil. An observational and cross-sectional study. Socio-demographic, economic, behavioral and reproductive health instruments were used, along with the Self-Reporting Questionnaire (SRQ-20) to identify common mental disorders. Multiple logistic regression was used for multivariate data analysis. 280 women participated in the study. The prevalence of Common Mental Disorders was 35.7%. In the logistic regression analysis, the variables of living with a partner and education level were associated with Common Mental Disorders, even after adjusting for the other variables. Our findings evidenced an association of social and behavioral factors with Common Mental Disorders among rural women. Identification and individualized care in primary health care are essential for the quality of life of these women. Identificar a prevalência do transtorno mental comum e analisar a influência de variáveis sociodemográficas, econômicas, comportamentais e de saúde reprodutiva sobre o transtorno mental comum em mulheres em idade fértil, residentes na zona rural do município de Uberaba-MG, Brasil. Estudo observacional e transversal. Foram utilizados instrumentos de caracterização sociodemográfica, econômica, comportamental e de saúde reprodutiva, e o Self-Reporting Questionnaire (SRQ-20) para identificar os transtornos mentais comuns. Na análise multivariada dos dados, foi utilizada a regressão logística múltipla. Participaram do estudo 280 mulheres. A prevalência do transtorno mental comum foi de 35,7%. Na análise de regressão logística, as variáveis convivência com o companheiro e escolaridade, associaram-se ao transtorno mental comum, mesmo após o ajuste para as demais variáveis. Os achados evidenciaram a

  11. Reviving common standards in point-count surveys for broad inference across studies

    Science.gov (United States)

    Matsuoka, Steven M.; Mahon, C. Lisa; Handel, Colleen M.; Solymos, Peter; Bayne, Erin M.; Fontaine, Patricia C.; Ralph, C.J.

    2014-01-01

    We revisit the common standards recommended by Ralph et al. (1993, 1995a) for conducting point-count surveys to assess the relative abundance of landbirds breeding in North America. The standards originated from discussions among ornithologists in 1991 and were developed so that point-count survey data could be broadly compared and jointly analyzed by national data centers with the goals of monitoring populations and managing habitat. Twenty years later, we revisit these standards because (1) they have not been universally followed and (2) new methods allow estimation of absolute abundance from point counts, but these methods generally require data beyond the original standards to account for imperfect detection. Lack of standardization and the complications it introduces for analysis become apparent from aggregated data. For example, only 3% of 196,000 point counts conducted during the period 1992-2011 across Alaska and Canada followed the standards recommended for the count period and count radius. Ten-minute, unlimited-count-radius surveys increased the number of birds detected by >300% over 3-minute, 50-m-radius surveys. This effect size, which could be eliminated by standardized sampling, was ≥10 times the published effect sizes of observers, time of day, and date of the surveys. We suggest that the recommendations by Ralph et al. (1995a) continue to form the common standards when conducting point counts. This protocol is inexpensive and easy to follow but still allows the surveys to be adjusted for detection probabilities. Investigators might optionally collect additional information so that they can analyze their data with more flexible forms of removal and time-of-detection models, distance sampling, multiple-observer methods, repeated counts, or combinations of these methods. Maintaining the common standards as a base protocol, even as these study-specific modifications are added, will maximize the value of point-count data, allowing compilation and

  12. BDD-based reliability evaluation of phased-mission systems with internal/external common-cause failures

    International Nuclear Information System (INIS)

    Xing, Liudong; Levitin, Gregory

    2013-01-01

    Phased-mission systems (PMS) are systems in which multiple non-overlapping phases of operations (or tasks) are accomplished in sequence for a successful mission. Examples of PMS abound in applications such as aerospace, nuclear power, and airborne weapon systems. Reliability analysis of a PMS must consider statistical dependence across different phases as well as dynamics in system configuration, failure criteria, and component behavior. This paper proposes a binary decision diagrams (BDD) based method for the reliability evaluation of non-repairable binary-state PMS with common-cause failures (CCF). CCF are simultaneous failure of multiple system elements, which can be caused by some external factors (e.g., lightning strikes, sudden changes in environment) or by propagated failures originating from some elements within the system. Both the external and internal CCF is considered in this paper. The proposed method is combinatorial, exact, and is applicable to PMS with arbitrary system structures and component failure distributions. An example with different CCF scenarios is analyzed to illustrate the application and advantages of the proposed method. -- Highlights: ► Non-repairable phased-mission systems with common-cause failures are analyzed. ► Common-cause failures caused by internal or external factors are considered. ► A combinatorial algorithm based on binary decision diagrams is suggested

  13. Microbial spoilage, instability risk of antacid suspension in the presence of commonly used preservative system.

    Science.gov (United States)

    Khan, Jamshaid Ali; Khan, Imran Ullah; Iqbal, Zafar; Nasir, Fazli; Muhammad, Salar; Hannan, Peer Abdul; Ullah, Irfan

    2015-09-01

    Manifestation of microbial spoilage of any product by bacteria and to assess the effectiveness of the anti-microbial preservatives (parabens) used for the prevention and stability purpose. The aim of the present work is to study the effectiveness of preservatives used in the antacid suspensions and to analyze the effect of microbial growth on the quality of respective antacid suspensions. Samples of various antacid suspensions were randomly collected from local market and Government hospital pharmacies. Three different antacid formulations were prepared in the laboratory. All the formulations were preliminarily evaluated on the basis of organoleptic characteristics, pH, viscosity and assay. Efficacy of the preservative system in suspension formulation was determined by inoculating the samples in its final container, with specific strains of bacteria i.e. Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 9027 and Staphylococcus aureus ATCC 6538, taking samples from the inoculated preparation at specified intervals of time i.e. 0 time, 07 days, 14 days and 28 days, growing it on nutrient agar medium and colony forming units (CFUs) were scored by plate count. At the same time the samples were also subjected to qualitative and quantitative testing. The decrease in CFU and alteration in assay, pH and viscosity was observed in all the formulations except formulation M2 and F3 that showed stability throughout the study period.

  14. Survival of enteric pathogens in common beverages: an in vitro study.

    Science.gov (United States)

    Sheth, N K; Wisniewski, T R; Franson, T R

    1988-06-01

    This in vitro study was undertaken to determine the potential for survival of enteric pathogens in common drinking beverages. Three carbonated soft drinks, two alcoholic beverages, skim milk, and water were inoculated with Salmonella, Shigella, and enterotoxigenic Escherichia coli, and quantitative counts were performed over 2 days. Our studies showed poorest survival of all three organisms in wine, and greatest growth in milk and water. Beer and cola allowed survival of small numbers of Salmonella and E. coli at 48 h, whereas sour mix and diet cola were sterile by 48 h. Survival features may correlate with pH of the beverages. These observations may be useful in guiding travellers for appropriate beverage consumption while visiting areas endemic for "traveller's diarrhea."

  15. One Common Future, Two Education Systems: The Case of Syrian Children of Istanbul

    Science.gov (United States)

    Ozer, Y. Yesim; Komsuoglu, Aysegul; Atesok, Z. Ozde

    2017-01-01

    The unexpected and vast Syrian refugee crisis with an ever-growing number of young Syrians appears to be one of the greatest challenges for the Turkish education system. While low enrollment rates are alarming, the dual system that emerged in the urban settings creates a main challenge to a comprehensive and supportive education system and…

  16. Marriage and Family Therapy and the Law: Discovering Systemic Common Ground

    Science.gov (United States)

    Richards, Jason C.

    2017-01-01

    Many important decisions regarding couples and families are made by the legal system. However, this system's adversarial nature often results in relational losses for clients, even when one "wins" a case. Some believe a solution may exist in legally-minded marriage and family therapists, who, as experts in family systems theory, are in a…

  17. Strengthening the systemic ties that bind: integrating common factors into marriage and family therapy curricula.

    Science.gov (United States)

    Karam, Eli A; Blow, Adrian J; Sprenkle, Douglas H; Davis, Sean D

    2015-04-01

    Specific models guide the training of marriage and family therapists (MFTs) as they offer both structure and organization for both therapists and clients. Learning models may also benefit therapists-in-training by instilling confidence and preventing atheoretical eclecticism. The moderate common factors perspective argues that models are essential, but should not be taught as "the absolute truth," given there is no evidence for relative efficacy of one empirically validated model versus another, and no single model works in all instances. The following article provides a blueprint for infusing a common factors perspective into MFT programmes by reviewing innovations in course design, outlining specific teaching strategies, and highlighting potential implementation challenges. © 2014 American Association for Marriage and Family Therapy.

  18. (m, M) Machining system with two unreliable servers, mixed spares and common-cause failure

    OpenAIRE

    Jain, Madhu; Mittal, Ragini; Kumari, Rekha

    2015-01-01

    This paper deals with multi-component machine repair model having provision of warm standby units and repair facility consisting of two heterogeneous servers (primary and secondary) to provide repair to the failed units. The failure of operating and standby units may occur individually or due to some common cause. The primary server may fail partially following full failure whereas secondary server faces complete failure only. The life times of servers and operating/standby units and their re...

  19. Diet and mortality from common cancers in Brazil: an ecological study

    Directory of Open Access Journals (Sweden)

    Sichieri Rosely

    1996-01-01

    Full Text Available A prospective ecological evaluation of mortality from common malignancies with dietary risk factors and alcohol consumption was carried out among 10 state capitals of Brazil. Regression analysis was used to examine the association of dietary intake with mortality rates of the most common cancers among adults age 30 years and older. Age-adjusted cancer mortality rates varied 2.4 to 3.3 fold across the state capitals. A positive relationship was observed between energy intake and colon, lung, and esophageal cancer (p<=0.02 for each. Colon cancer mortality was positively associated with consumption of total fat, eggs, alcohol, mate tea, cereals, and vegetables (p<=0.01. Lung cancer was positively associated with mate and cereal intake (p<0.05. Stomach cancer was associated with consumption of eggs (p=0.04; and negatively associated with consumption of high fiber foods, fruits, and vitamin A and C (p<=0.05. Esophageal cancer was positively associated with fat intake, mate and cereals (p<=0.05 and negatively associated with vitamin A (p=0.02; prostate cancer was negatively associated with vitamin C (p=0.007. Breast cancer was not associated with any of the factors studied. The marked variation in cancer mortality rates in Brazil may be partially related to the high variation in dietary components or other diet associated factors.

  20. Diet and mortality from common cancers in Brazil: an ecological study

    Directory of Open Access Journals (Sweden)

    Rosely Sichieri

    Full Text Available A prospective ecological evaluation of mortality from common malignancies with dietary risk factors and alcohol consumption was carried out among 10 state capitals of Brazil. Regression analysis was used to examine the association of dietary intake with mortality rates of the most common cancers among adults age 30 years and older. Age-adjusted cancer mortality rates varied 2.4 to 3.3 fold across the state capitals. A positive relationship was observed between energy intake and colon, lung, and esophageal cancer (p<=0.02 for each. Colon cancer mortality was positively associated with consumption of total fat, eggs, alcohol, mate tea, cereals, and vegetables (p<=0.01. Lung cancer was positively associated with mate and cereal intake (p<0.05. Stomach cancer was associated with consumption of eggs (p=0.04; and negatively associated with consumption of high fiber foods, fruits, and vitamin A and C (p<=0.05. Esophageal cancer was positively associated with fat intake, mate and cereals (p<=0.05 and negatively associated with vitamin A (p=0.02; prostate cancer was negatively associated with vitamin C (p=0.007. Breast cancer was not associated with any of the factors studied. The marked variation in cancer mortality rates in Brazil may be partially related to the high variation in dietary components or other diet associated factors.

  1. Strategies to keep working among workers with common mental disorders - a grounded theory study.

    Science.gov (United States)

    Danielsson, Louise; Elf, Mikael; Hensing, Gunnel

    2017-11-28

    Most people with common mental disorders (CMDs) are employed and working, but few studies have looked into how they manage their jobs while ill. This study explores workers' experiences of strategies to keep working while suffering from CMDs. In this grounded theory study, we interviewed 19 women and eight men with depression or anxiety disorders. They were 19-65 years old and had different occupations. Constant comparison method was used in the analysis. We identified a core pattern in the depressed and anxious workers' attempts to sustain their capacities, defined as Managing work space. The core pattern comprised four categories describing different cognitive, behavioral, and social strategies. The categories relate to a process of sustainability. Two categories reflected more reactive and temporary strategies, occurring mainly in the onset phase of illness: Forcing the work role and Warding off work strain. The third category, Recuperating from work, reflected strategies during both onset and recovery phases. The fourth category, Reflexive adaptation, was present mainly in the recovery phase and involved reflective strategies interpreted as more sustainable over time. The results can deepen understanding among rehabilitation professionals about different work-related strategies in depressed and anxious workers. Increased awareness of the meaning and characteristics of strategies can inform a person-oriented approach in rehabilitation. The knowledge can be used in clinical encounters to reflect together with the patient, exploring present options and introducing modifications to their particular work and life context. Implications for rehabilitation Self-managed work functioning in common mental disorders involves diverse strategies. Strategies interpreted as sustainable over time, seem to be reflective in the sense that the worker consciously applies and adapts the strategies. However, at the onset of illness, such reflection is difficult to develop as the

  2. Type-IVC Secretion System: A Novel Subclass of Type IV Secretion System (T4SS) Common Existing in Gram-Positive Genus Streptococcus

    Science.gov (United States)

    Chen, Chen; Gao, George F.

    2012-01-01

    A growing number of pathogens are being found to possess specialized secretion systems which they use in various ways to subvert host defenses. Type IV secretion system (T4SS) is one of versatile secretion systems essential for the virulence and even survival of some bacteria species, and they enable the secretion of protein and DNA substrates across the cell envelope. T4SS was once believed to be present only in Gram-negative bacteria. In this study, we present evidence of a new subclass of T4SS, Type-IVC secretion system and indicate its common existence in the Gram-positive bacterial genus Streptococcus. We further identified that VirB1, VirB4, VirB6 and VirD4 are the minimal key components of this system. Using genome comparisons and evolutionary relationship analysis, we proposed that Type-IVC secretion system is movable via transposon factors and mediates the conjugative transfer of DNA, enhances bacterial pathogenicity, and could cause large-scale outbreaks of infections in humans. PMID:23056296

  3. Identification of common features of vehicle motion under drowsy/distracted driving: A case study in Wuhan, China.

    Science.gov (United States)

    Chen, Zhijun; Wu, Chaozhong; Zhong, Ming; Lyu, Nengchao; Huang, Zhen

    2015-08-01

    effectively extracting the two common features, a double-window method was used and the optimized "Parent Window" and "Child Window" were found to be 55s and 6s, respectively. The study results can be used to develop a driving assistant system, which can warn drivers when any one of the four types of drowsy/distracted driving is detected. Copyright © 2015. Published by Elsevier Ltd.

  4. Ethics and observational studies in medical research: various rules in a common framework

    Science.gov (United States)

    Claudot, Frédérique; Alla, François; Fresson, Jeanne; Calvez, Thierry; Coudane, Henry; Bonaïti-Pellié, Catherine

    2009-01-01

    Background Research ethics have become universal in their principles through international agreements. The standardization of regulations facilitates the internationalization of research concerning drugs. However, in so-called observational studies (i.e. from data collected retrospectively or prospectively, obtained without any additional therapy or monitoring procedure), the modalities used for applying the main principles vary from one country to the other. This situation may entail problems for the conduct of multi-centric international studies, as well as for the publication of results if the authors and editors come from countries governed by different regulations. In particular, several French observational studies were rejected or retracted by United States peer reviewed journals, because their protocols have not been submitted to an Institutional Review Board/Independent Ethics Committee (IRB/IEC). Methods national legislation case analysis Results In accordance with European regulation, French observational studies from data obtained without any additional therapy or monitoring procedure, do not need the approval of an IRB/IEC. Nevertheless, these researches are neither exempt from scientific opinion nor from ethical and legal authorization. Conclusion We wish to demonstrate through the study of this example that different bodies of law can provide equivalent levels of protection that respect the same ethical principles. Our purpose in writing this paper was to encourage public bodies, scientific journals, and researchers to gain a better understanding of the various sets of specific national regulations and to speak a common language. PMID:19336436

  5. Navigating systems ideas for health practice: Towards a common learning device.

    Science.gov (United States)

    Reynolds, Martin; Sarriot, Eric; Swanson, Robert Chad; Rusoja, Evan

    2018-06-01

    Systems thinking and reference to complexity science have gained currency in health sector practice and research. The extent to which such ideas might represent a mere passing fad or might more usefully be mobilized to tackle wicked problems in health systems is a concern underpinning this paper. Developing the usefulness of the systems idea requires appreciating how systems ideas are used essentially as constructs conceptually bounded by practitioners. Systems are used for purposes of understanding and engaging the reality of health issues, with the intent of transforming the reality into one that is more manageable, equitable, and sustainable. We examine some manifestations of the systems idea in health practice and the traditions of systems practice that variously make use of them. This provides a platform for proposing a systems thinking in (health) practice heuristic: a learning device supporting how different tools and methods can address "wicked problems" in health praxis. The device is built on the use of "conversation" as a metaphor to help practitioners use systems ideas in tandem with existing disciplinary and professional skills and methods. We consider how the application of the heuristic requires, and helps to develop, human characteristics of humility, empathy, and recognition of fallibility. © 2018 John Wiley & Sons, Ltd.

  6. Anatomical study of the final common pathway for vocalization in the cat

    Science.gov (United States)

    Holstege, Gert

    1989-01-01

    Results are presented of an anatomical study of the neuronal pathways in the cat, via which the periaqueductal gray (PAG) produces excitation of motoneurons involved in vocalization. It is shown that a specific cell group in the lateral part of the caudal PAG and in the tegmentum just lateral to it projects bilaterally to the nucleus retroambiguus (NRA) in the caudal medulla oblongata. Neurons in the NRA in turn project, via a contralateral pathway through the ventral funiculus of the spinal cord, to the motoneuronal cell groups innervating intercostal and abdominal muscles. In the brainstem, the NRA neurons project to the motoneuronal cell groups innervating mouth-opening and perioral muscles as well as to motoneurons innervating the pharynx, soft palate, and tongue. These results indicate that the projections from PAG via NRA to vocalization motoneurons form the final common pathway in vocalization.

  7. Comparison Study of Three Common Technologies for Freezing-Thawing Measurement

    Directory of Open Access Journals (Sweden)

    Xinbao Yu

    2010-01-01

    Full Text Available This paper describes a comparison study on three different technologies (i.e., thermocouple, electrical resistivity probe and Time Domain Reflectometry (TDR that are commonly used for frost measurement. Specially, the paper developed an analyses procedure to estimate the freezing-thawing status based on the dielectric properties of freezing soil. Experiments were conducted where the data of temperature, electrical resistivity, and dielectric constant were simultaneously monitored during the freezing/thawing process. The comparison uncovered the advantages and limitations of these technologies for frost measurement. The experimental results indicated that TDR measured soil dielectric constant clearly indicates the different stages of the freezing/thawing process. Analyses method was developed to determine not only the onset of freezing or thawing, but also the extent of their development. This is a major advantage of TDR over other technologies.

  8. Analytical Study of Common Rigid Steel Connections under the Effect of Heat

    Directory of Open Access Journals (Sweden)

    Rohola Rahnavard

    2014-01-01

    Full Text Available One of the most important members of steel structure’s connection region is beam-to-column connection. Rigid connection in steel moment frame has special role in the behavior of these structures and the fire resistance of these connections can be important. In this paper the behaviors of three common types of rigid connections in Iran under the effect of heat were studied by the use of numerical finite element methods through ABAQUS software. The models were verified by the use of an experimental model through elastic and plastic amplitudes up to collapse and during numerical results, and the effect of large deformation in the nonlinear region has also been considered. The results show that the connection with the end plate had a better performance against heat than other connections. Also reduced stiffness and lateral buckling in this connection were less than other connections.

  9. The common European asylum system and the rights of the child : an exploration of meaning and compliance

    NARCIS (Netherlands)

    Smyth, Ciara Mary

    2013-01-01

    This thesis addresses the question of whether the EU Common European Asylum System (CEAS) complies with the rights of the child. A significant proportion of people seeking asylum in EU countries are children. These children may be totally alone, with people who are not their customary caregivers

  10. Expression of immune system-related genes during ontogeny in experimentally wounded common carp (Cyprinus carpio) larvae and juveniles

    DEFF Research Database (Denmark)

    Schmidt, Jacob; Nielsen, Michael Engelbrecht

    2014-01-01

    We investigated the effect of full-thickness incisional wounding on expression of genes related to the immune system in larvae and juveniles of common carp (Cyprinus carpio). The wounds were inflicted by needle puncture immediately below the anterior part of the dorsal fin on days 7, 14, 28 and 49...

  11. Prolonged internal displacement and common mental disorders in Sri Lanka: the COMRAID study.

    Science.gov (United States)

    Siriwardhana, Chesmal; Adikari, Anushka; Pannala, Gayani; Siribaddana, Sisira; Abas, Melanie; Sumathipala, Athula; Stewart, Robert

    2013-01-01

    Evidence is lacking on the mental health issues of internally displaced persons, particularly where displacement is prolonged. The COMRAID study was carried out in year 2011 as a comprehensive evaluation of Muslims in North-Western Sri Lanka who had been displaced since 1990 due to conflict, to investigate the prevalence and correlates of common mental disorders. A cross-sectional survey was carried out among a randomly selected sample of internally displaced people who had migrated within last 20 years or were born in displacement. The total sample consisted of 450 adults aged 18-65 years selected from 141 settlements. Common mental disorders (CMDs) and post-traumatic stress disorder (PTSD) prevalences were measured using the Patient Health Questionnaire and CIDI sub-scale respectively. The prevalence of any CMD was 18.8%, and prevalence for subtypes was as follows: somatoform disorder 14.0%, anxiety disorder 1.3%, major depression 5.1%, other depressive syndromes 7.3%. PTSD prevalence was 2.4%. The following factors were significantly associated with CMDs: unemployment (odds ratio 2.8, 95% confidence interval 1.6-4.9), widowed or divorced status (4.9, 2.3-10.1) and food insecurity (1.7, 1.0-2.9). This is the first study investigating the mental health impact of prolonged forced displacement in post-conflict Sri Lanka. Findings add new insight in to mental health issues faced by internally displaced persons in Sri Lanka and globally, highlighting the need to explore broader mental health issues of vulnerable populations affected by forced displacement.

  12. Atlas Career Path Guidebook: Patterns and Common Practices in Systems Engineers’ Development

    Science.gov (United States)

    2018-01-16

    text mining principles to be used by systems...statistical and text mining principles facilitate the identification of patterns. Figure 1. Helix methodology for career path analysis In order to...illustrate how text mining algorithms might be used to identify similarities in position titles for systems engineers. In broad

  13. XML schemas for common bioinformatic data types and their application in workflow systems.

    Science.gov (United States)

    Seibel, Philipp N; Krüger, Jan; Hartmeier, Sven; Schwarzer, Knut; Löwenthal, Kai; Mersch, Henning; Dandekar, Thomas; Giegerich, Robert

    2006-11-06

    Today, there is a growing need in bioinformatics to combine available software tools into chains, thus building complex applications from existing single-task tools. To create such workflows, the tools involved have to be able to work with each other's data--therefore, a common set of well-defined data formats is needed. Unfortunately, current bioinformatic tools use a great variety of heterogeneous formats. Acknowledging the need for common formats, the Helmholtz Open BioInformatics Technology network (HOBIT) identified several basic data types used in bioinformatics and developed appropriate format descriptions, formally defined by XML schemas, and incorporated them in a Java library (BioDOM). These schemas currently cover sequence, sequence alignment, RNA secondary structure and RNA secondary structure alignment formats in a form that is independent of any specific program, thus enabling seamless interoperation of different tools. All XML formats are available at http://bioschemas.sourceforge.net, the BioDOM library can be obtained at http://biodom.sourceforge.net. The HOBIT XML schemas and the BioDOM library simplify adding XML support to newly created and existing bioinformatic tools, enabling these tools to interoperate seamlessly in workflow scenarios.

  14. XML schemas for common bioinformatic data types and their application in workflow systems

    Science.gov (United States)

    Seibel, Philipp N; Krüger, Jan; Hartmeier, Sven; Schwarzer, Knut; Löwenthal, Kai; Mersch, Henning; Dandekar, Thomas; Giegerich, Robert

    2006-01-01

    Background Today, there is a growing need in bioinformatics to combine available software tools into chains, thus building complex applications from existing single-task tools. To create such workflows, the tools involved have to be able to work with each other's data – therefore, a common set of well-defined data formats is needed. Unfortunately, current bioinformatic tools use a great variety of heterogeneous formats. Results Acknowledging the need for common formats, the Helmholtz Open BioInformatics Technology network (HOBIT) identified several basic data types used in bioinformatics and developed appropriate format descriptions, formally defined by XML schemas, and incorporated them in a Java library (BioDOM). These schemas currently cover sequence, sequence alignment, RNA secondary structure and RNA secondary structure alignment formats in a form that is independent of any specific program, thus enabling seamless interoperation of different tools. All XML formats are available at , the BioDOM library can be obtained at . Conclusion The HOBIT XML schemas and the BioDOM library simplify adding XML support to newly created and existing bioinformatic tools, enabling these tools to interoperate seamlessly in workflow scenarios. PMID:17087823

  15. Societal acceptance of wind farms: Analysis of four common themes across Australian case studies

    International Nuclear Information System (INIS)

    Hall, N.; Ashworth, P.; Devine-Wright, P.

    2013-01-01

    Australia's renewable energy target (RET) seeks to provide 20 per cent of Australia's electricity generation from renewable energy sources by 2020. As wind power is relatively advanced, it was anticipated that wind power will contribute a major component of the early target. However, high levels of societal resistance to wind farms, combined with new regulatory policies, indicate the RET may not be dominated by wind power. This research involved an examination of seven case studies around wind farm deployment. Qualitative interviews were the primary data for the case studies and analysed using methods informed by grounded theory. Despite the diversity of stakeholder views, the qualitative analysis identified strong community support for wind farms but four common themes emerged that influence this societal acceptance of wind farms in Australia: trust, distributional justice, procedural justice and place attachment. Without addressing these factors through integration into policy development and engagement approaches, wind energy is unlikely to provide the early and majority of new renewable energy. Similar international experiences are incorporated in the discussion of the Australian wind industry's societal acceptance. - Highlights: ► Seven case studies of wind farms in Australia are described. ► Acceptance affects whether wind significantly contributes to the Aust. RE target. ► Four themes were identified regarding societal acceptance of Australian wind farms. ► Four themes are trust, distributional and procedural justice, and place attachment. ► International similarities to the Australian experience are provided

  16. Histopathological study of common carp (Cyprinus carpio fed aflatoxin-contaminated diets

    Directory of Open Access Journals (Sweden)

    Shima Shahafve

    2017-04-01

    Full Text Available This study aimed to evaluate the effects of aflatoxin-contaminated diet on histopathological alterations of the gill, liver, kidney and intestine tissues in common carp. Fish were randomly distributed into 15 tanks, i.e. in five experimental groups; (I control fed with normal diet without solvent and aflatoxin, (II positive control received feed with only solvent, and (III-V fed on diets containing 0.5, 0.7 and 1.4 mg kg-1 of aflatoxin, respectively. After 21-days, 12 fish per treatment were randomly caught, anesthetized and euthanized. Then, histological sections of the tissues were prepared. The main aflatoxicosis symptoms in the gills were fusion and disorganisation of the secondary gill lamellae, shortening of the secondary lamellae, inflammation of mucous membranes, and exfoliation of the gill epithelium. Liver of the infected fish indicated cloudy swelling of hepatocytes, cellular hypertrophy, formation of vacuoles in the cytoplasm, and necrosis of liver parenchyma. Expansion of Bowman’s space, necrosis of urinary tract, exfoliation and degeneration of the urinary tract epithelium, expansion of the urinary lumen and dilation of the urinary space were observed symptoms in the kidney. Changes in the intestine of the aflatoxin-treated fish were; expansion of goblet cells, necrosis of mucous layers, exfoliation of the mucous epithelium, and bleeding in the intestinal wall. The results indicates that feeding common carp with diets contaminated with aflatoxin, even in low concentrations (≤ 1.4 mg kg-1 feed can cause histopathological damages and disturb their physiological balance.

  17. Peristomal Skin Complications Are Common, Expensive, and Difficult to Manage: A Population Based Cost Modeling Study

    Science.gov (United States)

    Meisner, Søren; Lehur, Paul-Antoine; Moran, Brendan; Martins, Lina; Jemec, Gregor Borut Ernst

    2012-01-01

    Background Peristomal skin complications (PSCs) are the most common post-operative complications following creation of a stoma. Living with a stoma is a challenge, not only for the patient and their carers, but also for society as a whole. Due to methodological problems of PSC assessment, the associated health-economic burden of medium to longterm complications has been poorly described. Aim The aim of the present study was to create a model to estimate treatment costs of PSCs using the standardized assessment Ostomy Skin Tool as a reference. The resultant model was applied to a real-life global data set of stoma patients (n = 3017) to determine the prevalence and financial burden of PSCs. Methods Eleven experienced stoma care nurses were interviewed to get a global understanding of a treatment algorithm that formed the basis of the cost analysis. The estimated costs were based on a seven week treatment period. PSC costs were estimated for five underlying diagnostic categories and three levels of severity. The estimated treatment costs of severe cases of PSCs were increased 2–5 fold for the different diagnostic categories of PSCs compared with mild cases. French unit costs were applied to the global data set. Results The estimated total average cost for a seven week treatment period (including appliances and accessories) was 263€ for those with PSCs (n = 1742) compared to 215€ for those without PSCs (n = 1172). A co-variance analysis showed that leakage level had a significant impact on PSC cost from ‘rarely/never’ to ‘always/often’ p<0.00001 and from ‘rarely/never’ to ‘sometimes’ p = 0.0115. Conclusion PSCs are common and troublesome and the consequences are substantial, both for the patient and from a health economic viewpoint. PSCs should be diagnosed and treated at an early stage to prevent long term, debilitating and expensive complications. PMID:22679479

  18. Peristomal skin complications are common, expensive, and difficult to manage: a population based cost modeling study.

    Directory of Open Access Journals (Sweden)

    Søren Meisner

    Full Text Available BACKGROUND: Peristomal skin complications (PSCs are the most common post-operative complications following creation of a stoma. Living with a stoma is a challenge, not only for the patient and their carers, but also for society as a whole. Due to methodological problems of PSC assessment, the associated health-economic burden of medium to longterm complications has been poorly described. AIM: The aim of the present study was to create a model to estimate treatment costs of PSCs using the standardized assessment Ostomy Skin Tool as a reference. The resultant model was applied to a real-life global data set of stoma patients (n = 3017 to determine the prevalence and financial burden of PSCs. METHODS: Eleven experienced stoma care nurses were interviewed to get a global understanding of a treatment algorithm that formed the basis of the cost analysis. The estimated costs were based on a seven week treatment period. PSC costs were estimated for five underlying diagnostic categories and three levels of severity. The estimated treatment costs of severe cases of PSCs were increased 2-5 fold for the different diagnostic categories of PSCs compared with mild cases. French unit costs were applied to the global data set. RESULTS: The estimated total average cost for a seven week treatment period (including appliances and accessories was 263€ for those with PSCs (n = 1742 compared to 215€ for those without PSCs (n = 1172. A co-variance analysis showed that leakage level had a significant impact on PSC cost from 'rarely/never' to 'always/often' p<0.00001 and from 'rarely/never' to 'sometimes' p = 0.0115. CONCLUSION: PSCs are common and troublesome and the consequences are substantial, both for the patient and from a health economic viewpoint. PSCs should be diagnosed and treated at an early stage to prevent long term, debilitating and expensive complications.

  19. Home e-health system integration in the Smart Home through a common media server.

    Science.gov (United States)

    Pau, I; Seoane, F; Lindecrantz, K; Valero, M A; Carracedo, J

    2009-01-01

    Home e-health systems and services are revealed as one of the most important challenges to promote Quality of Life related to Health in the Information Society. Leading companies have worked on e-health systems although the majority of them are addressed to hospital or primary care settings. The solution detailed in this paper offers a personal health system to be integrated with Smart Home services platform to support home based e-care. Thus, the home e-health system and architecture detailed in this research work is ready to supply a seamless personal care solution both from the biomedical data analysis, service provision, security guarantee and information management s point of view. The solution is ready to be integrated within the Accessible Digital Home, a living lab managed by Universidad Politécnica de Madrid for R&D activities.

  20. Dynamic simulation of electromechanical systems: from Maxwell's theory to common-rail diesel injection.

    Science.gov (United States)

    Kurz, S; Becker, U; Maisch, H

    2001-05-01

    This paper describes the state-of-the-art of dynamic simulation of electromechanical systems. Electromechanical systems can be split into electromagnetic and mechanical subsystems, which are described by Maxwell's equations and by Newton's law, respectively. Since such systems contain moving parts, the concepts of Lorentz and Galilean relativity are briefly addressed. The laws of physics are formulated in terms of (partial) differential equations. Numerical methods ultimately aim at linear systems of equations, which can be solved efficiently on digital computers. The various discretization methods for performing this task are discussed. Special emphasis is placed on domain decomposition as a framework for the coupling of different numerical methods such as the finite element method and the boundary element method. The paper concludes with descriptions of some applications of industrial relevance: a high performance injection valve and an electromechanical relay.

  1. A Common Software-Configuration Management System for CERN SPS and LEP Accelerators and Technical Services

    CERN Document Server

    Hatziangeli, Eugenia; Bragg, A E; Ninin, P; Patino, J; Sobczak, H

    2000-01-01

    Software-configuration management activities are crucial to ensure the integrity of current operational software and the quality of new software either being developed at CERN or outsourced. The functionality of the present management system became insufficient with large maintenance overheads. In order to improve our situation, a new software-configuration management system has been set up. It is based on Razor R, a commercial tool, which supports the management of file versions and operational software releases, along with integrated problem-reporting capabilities. In addition to the basic tool functionality, automated procedures were custom-made for the installation and distribution of operational software. The system ensures that, at all times, the status and location of all deliverable versions are known, the state of shared objects is carefully controlled and unauthorized changes prevented. This paper outlines the reasons for selecting the chosen tool, the implementation of the system and the final goal...

  2. Is there a common SUV threshold in oncological FDG PET/CT, at least for some common indications? A retrospective study

    International Nuclear Information System (INIS)

    Nguyen, Nghi C.; Kaushik, Aarti; Wolverson, Michael K.; Osman, Medhat M.

    2011-01-01

    Purpose. We retrospectively compared the maximum standard uptake value (SUVmax) of FDG PET in four different sites to evaluate whether a common diagnostic SUVmax threshold may exist in these tumor locations. We further postulate that the SUVmax thresholds are higher in thoracic lesions than in extrathoracic lesions. Material and methods. N = 143 patients in four subgroups underwent a FDG PET/CT: a) 42 patients for solitary pulmonary nodules (SPNs) characterization with b) respective mediastinal lymph nodes (LNs), c) 65 patients for LN staging of head and neck cancer, and d) 36 cancer patients diagnosed with adrenal lesions. Receiver operating characteristics of SUVmax values were evaluated. Results. The SUVmax were statistically significantly greater in malignant than in benign lesions. For SPNs and mediastinal LNs, a SUVmax > 3.6 each resulted in a sensitivity of 81% and 87%, and a specificity of 94% and 89%. For cervical LNs and adrenal glands, a SUVmax > 2.2 each showed a sensitivity of 98% and 100%, and a specificity of 83% and 93%. Conclusion. A common SUVmax threshold did not exist in the four studied subgroups. The variable FDG uptake in SPNs and mediastinal LNs are associated with the high prevalence of inflammation/infection within the chest. Similar SUVmax thresholds however may exist for extrathoracic regions where the prevalence of inflammation/infection is low

  3. New isolation and control concept for large pulse power systems or common mode plus

    International Nuclear Information System (INIS)

    Rupert, P.R.; Gagnon, W.L.; Berkbigler, L.W.; Gritton, D.G.

    1977-01-01

    At the time of this writing, 10 of the 20 Shiva arms have been successfully brought up and fired electrically. In addition to this success, more than 50 hard arc faults have occurred during the debug phase of the bank, and none of these have penetrated the control system past the BIU's. For more than 95% of these faults, the control system continued to function during the occurence and promptly pinpointed the failed area

  4. Spin Is Common in Studies Assessing Robotic Colorectal Surgery: An Assessment of Reporting and Interpretation of Study Results.

    Science.gov (United States)

    Patel, Sunil V; Van Koughnett, Julie Ann M; Howe, Brett; Wexner, Steven D

    2015-09-01

    Spin has been defined previously as "specific reporting that could distort the interpretation of results and mislead readers." The purpose of this study was to determine the frequency and extent of misrepresentation of results in robotic colorectal surgery. Publications referenced in MEDLINE or EMBASE between 1992 and 2014 were included in this study. Studies comparing robotic colorectal surgery with other techniques with a nonsignificant difference in the primary outcome(s) were included. Interventions included robotic versus alternative techniques. Frequency, strategy, and extent of spin, as previously defined, were the main outcome measures : A total of 38 studies (including 24,303 patients) were identified for inclusion in this study. Evidence of spin was found in 82% of studies. The most common form of spin was concluding equivalence between surgical techniques based on nonsignificant differences (76% of abstracts and 71% of conclusions). Claiming improved benefits, despite nonsignificance, was also commonly observed (26% of abstracts and 45% of conclusions). Because of the small sample size, we did not find evidence of an association between spin and study design, type of funding, publication year, or study size. Acknowledging the equivocal nature of the study happened rarely (47% of abstracts and 34% of conclusions). The absence of spin predicted whether authors acknowledged equivocal results (p = 0.02). A total of 50% of studies did not disclose whether they received funding, whereas 39% of studies failed to state whether a conflict of interest existed. A limited number of randomized controlled trials were available. Spin occurred in >80% of included studies. Many studies concluded that robotic surgery was as safe as more traditional techniques, despite small sample sizes and limited follow-up. Authors often failed to recognize the difference between nonsignificance and equivalence. Failure to disclose financial relationships, which could represent

  5. A microcontroller system for investigating the catch effect: functional electrical stimulation of the common peroneal nerve.

    Science.gov (United States)

    Hart, D J; Taylor, P N; Chappell, P H; Wood, D E

    2006-06-01

    Correction of drop foot in hemiplegic gait is achieved by electrical stimulation of the common peroneal nerve with a series of pulses at a fixed frequency. However, during normal gait, the electromyographic signals from the tibialis anterior muscle indicate that muscle force is not constant but varies during the swing phase. The application of double pulses for the correction of drop foot may enhance the gait by generating greater torque at the ankle and thereby increase the efficiency of the stimulation with reduced fatigue. A flexible controller has been designed around the Odstock Drop Foot Stimulator to deliver different profiles of pulses implementing doublets and optimum series. A peripheral interface controller (PIC) microcontroller with some external circuits has been designed and tested to accommodate six profiles. Preliminary results of the measurements from a normal subject seated in a multi-moment chair (an isometric torque measurement device) indicate that profiles containing doublets and optimum spaced pulses look favourable for clinical use.

  6. Nephrolithiasis as a common urinary system manifestation of inflammatory bowel diseases; a clinical review and meta-analysis.

    Science.gov (United States)

    Ganji-Arjenaki, Mahboube; Nasri, Hamid; Rafieian-Kopaei, Mahmoud

    2017-07-01

    The extra-intestinal manifestations of inflammatory bowel disease (IBD) are common and involve other organs or systems for example; urinary system. For this review, we used a variety of sources by searching through Web of Science, PubMed, EMBASE, Scopus and directory of open access journals (DOAJ). Urinary complications may occur in up to 22% of patients and nephrolithiasis or renal/kidney stones have been suggested to be a common manifestation of disease in forms of uric acid, calcium phosphate or calcium oxalate. We performed a meta-analysis on five clinical trials and reported that correlation between IBD and formation of stone in renal system is positive and significant (Fix-effect model; CI: 95%, P <0.001, and randomeffect model; CI: 95%, P = 0.03). Based on the reports of the clinical trials, calcium oxalate is more prevalent in Crohn's disease (CD) than in ulcerative colitis (UC).

  7. The Common Core State Standards and the Role of Instructional Materials: A Case Study on EdReports.org

    Science.gov (United States)

    Watt, Michael G.

    2016-01-01

    The purpose of this study was to review research studies investigating the role of instructional materials in relation to the Common Core State Standards and to evaluate whether a new organisation, EdReports.org, founded to evaluate the alignment of instructional materials to the Common Core State Standards, has achieved its objectives. Content…

  8. Emergence of a common generalized synchronization manifold in network motifs of structurally different time-delay systems

    International Nuclear Information System (INIS)

    Suresh, R.; Senthilkumar, D.V.; Lakshmanan, M.; Kurths, J.

    2016-01-01

    Highlights: • We have identified that a common generalized synchronization manifold exist for symmetrically coupled structurally different time-delay systems with different orders. • We have provided a theoretical formulation for the existence of a common generalized synchronization manifold based on the auxiliary system approach. • We have pointed out the existence of a transition from partial to global generalized synchronization. • We have corroborated our results using the maximal transverse Lyapunov exponent, correlation coefficient, mutual false nearest neighbor method. - Abstract: We point out the existence of a transition from partial to global generalized synchronization (GS) in symmetrically coupled structurally different time-delay systems of different orders using the auxiliary system approach and the mutual false nearest neighbor method. The present authors have recently reported that there exists a common GS manifold even in an ensemble of structurally nonidentical scalar time-delay systems with different fractal dimensions and shown that GS occurs simultaneously with phase synchronization (PS). In this paper we confirm that the above result is not confined just to scalar one-dimensional time-delay systems alone but there exists a similar type of transition even in the case of time-delay systems with different orders. We calculate the maximal transverse Lyapunov exponent to evaluate the asymptotic stability of the complete synchronization manifold of each of the main and the corresponding auxiliary systems, which in turn ensures the stability of the GS manifold between the main systems. Further we estimate the correlation coefficient and the correlation of probability of recurrence to establish the relation between GS and PS. We also calculate the mutual false nearest neighbor parameter which doubly confirms the occurrence of the global GS manifold.

  9. Effects of Commonly Used Pesticides in China on the Mitochondria and Ubiquitin-Proteasome System in Parkinson’s Disease

    Directory of Open Access Journals (Sweden)

    Tingting Chen

    2017-11-01

    Full Text Available Evidence continues to accumulate that pesticides are the leading candidates of environmental toxins that may contribute to the pathogenesis of Parkinson’s disease. The mechanisms, however, remain largely unclear. According to epidemiological studies, we selected nine representative pesticides (paraquat, rotenone, chlorpyrifos, pendimethalin, endosulfan, fenpyroximate, tebufenpyrad, trichlorphon and carbaryl which are commonly used in China and detected the effects of the pesticides on mitochondria and ubiquitin-proteasome system (UPS function. Our results reveal that all the nine studied pesticides induce morphological changes of mitochondria at low concentrations. Paraquat, rotenone, chlorpyrifos, pendimethalin, endosulfan, fenpyroximate and tebufenpyrad induced mitochondria fragmentation. Furthermore, some of them (paraquat, rotenone, chlorpyrifos, fenpyroximate and tebufenpyrad caused a significant dose-dependent decrease of intracellular ATP. Interestingly, these pesticides which induce mitochondria dysfunction also inhibit 26S and 20S proteasome activity. However, two out of the nine pesticides, namely trichlorphon and carbaryl, were found not to cause mitochondrial fragmentation or functional damage, nor inhibit the activity of the proteasome, which provides significant guidance for selection of pesticides in China. Moreover, our results demonstrate a potential link between inhibition of mitochondria and the UPS, and pesticide-induced Parkinsonism.

  10. Statistical inferences under the Null hypothesis: Common mistakes and pitfalls in neuroimaging studies.

    Directory of Open Access Journals (Sweden)

    Jean-Michel eHupé

    2015-02-01

    Full Text Available Published studies using functional and structural MRI include many errors in the way data are analyzed and conclusions reported. This was observed when working on a comprehensive review of the neural bases of synesthesia, but these errors are probably endemic to neuroimaging studies. All studies reviewed had based their conclusions using Null Hypothesis Significance Tests (NHST. NHST have yet been criticized since their inception because they are more appropriate for taking decisions related to a Null hypothesis (like in manufacturing than for making inferences about behavioral and neuronal processes. Here I focus on a few key problems of NHST related to brain imaging techniques, and explain why or when we should not rely on significance tests. I also observed that, often, the ill-posed logic of NHST was even not correctly applied, and describe what I identified as common mistakes or at least problematic practices in published papers, in light of what could be considered as the very basics of statistical inference. MRI statistics also involve much more complex issues than standard statistical inference. Analysis pipelines vary a lot between studies, even for those using the same software, and there is no consensus which pipeline is the best. I propose a synthetic view of the logic behind the possible methodological choices, and warn against the usage and interpretation of two statistical methods popular in brain imaging studies, the false discovery rate (FDR procedure and permutation tests. I suggest that current models for the analysis of brain imaging data suffer from serious limitations and call for a revision taking into account the new statistics (confidence intervals logic.

  11. A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency.

    Science.gov (United States)

    Jørgensen, Silje F; Reims, Henrik M; Frydenlund, Didrik; Holm, Kristian; Paulsen, Vemund; Michelsen, Annika E; Jørgensen, Kristin K; Osnes, Liv T; Bratlie, Jorunn; Eide, Tor J; Dahl, Christen P; Holter, Ellen; Tronstad, Rune R; Hanevik, Kurt; Brattbakk, Hans-Richard; Kaveh, Fatemeh; Fiskerstrand, Torunn; Kran, Anne-Marte B; Ueland, Thor; Karlsen, Tom H; Aukrust, Pål; Lundin, Knut E A; Fevang, Børre

    2016-10-01

    The objective of this study was to study the prevalence of gastrointestinal (GI) symptoms and histopathology in patients with common variable immunodeficiency (CVID) as well as linking the findings to GI infections and markers of systemic immune activation. In this cross-sectional study, we addressed GI symptoms in 103 patients and GI histopathological findings in 53 patients who underwent upper and lower endoscopic examination. The most frequent histopathological findings were linked to GI symptoms, B-cell phenotype, and markers of systemic immune activation (soluble (s)CD14, sCD25, and sCD163). Microarray analysis compared "celiac-like disease" in CVID to celiac disease. Screening for selected bacterial and viral infections in fecal samples and gut mucosal biopsies was performed. The main findings of this study were as follows: most common GI symptoms were bloating (34%), pain (30%), and diarrhea (26%). The most frequent histopathological findings were increased intraepithelial lymphocytes in the descending part of the duodenum, i.e., "celiac-like disease" (46% of patients), decreased numbers of plasma cells in GI tract mucosa (62%), and lymphoid hyperplasia (38%), none of which were associated with GI symptoms. Reduced plasma cells in GI mucosa were associated with B-cell phenotypic characteristics of CVID, and increased serum levels of sCD14 (P=0.025), sCD25 (P=0.01), and sCD163 (P=0.04). Microarray analyses distinguished between CVID patients with "celiac-like disease" and celiac disease. Positive tests for bacterial and viral infections were scarce both in fecal samples and gut mucosal biopsies, including PCR test for norovirus in biopsy specimens (0 positive tests). In conclusion, GI pathology is common in CVID, but does not necessarily cause symptoms. However, reduced plasma cells in GI mucosa were linked to systemic immune activation, "celiac-like disease" in CVID and true celiac disease appear to be different disease entities, as assessed by gene

  12. Exploratory Study of Common and Challenging Ethical Dilemmas Experienced by Professional School Counselors

    Science.gov (United States)

    Bodenhorn, Nancy

    2006-01-01

    Results of a survey asking public school counselors in Virginia to indicate their most common and most challenging ethical dilemmas are presented. Ninety-two school counselors reported that the most common and challenging ethical dilemmas included those involving student confidentiality, dual relationship with faculty, parental rights, and acting…

  13. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

    NARCIS (Netherlands)

    Lanktree, Matthew B.; Guo, Yiran; Murtaza, Muhammed; Glessner, Joseph T.; Bailey, Swneke D.; Onland-Moret, N. Charlotte; Lettre, Guillaume; Ongen, Halit; Rajagopalan, Ramakrishnan; Johnson, Toby; Shen, Haiqing; Nelson, Christopher P.; Klopp, Norman; Baumert, Jens; Padmanabhan, Sandosh; Pankratz, Nathan; Pankow, James S.; Shah, Sonia; Taylor, Kira; Barnard, John; Peters, Bas J.; Maloney, Cliona M.; Lobmeyer, Maximilian T.; Stanton, Alice; Zafarmand, M. Hadi; Romaine, Simon P. R.; Mehta, Amar; van Iperen, Erik P. A.; Gong, Yan; Price, Tom S.; Smith, Erin N.; Kim, Cecilia E.; Li, Yun R.; Asselbergs, Folkert W.; Atwood, Larry D.; Bailey, Kristian M.; Bhatt, Deepak; Bauer, Florianne; Behr, Elijah R.; Bhangale, Tushar; Boer, Jolanda M. A.; Boehm, Bernhard O.; Bradfield, Jonathan P.; Brown, Morris; Braund, Peter S.; Burton, Paul R.; Carty, Cara; Chandrupatla, Hareesh R.; Chen, Wei; Connell, John; Dalgeorgou, Chrysoula; de Boer, Anthonius; Drenos, Fotios; Elbers, Clara C.; Fang, James C.; Fox, Caroline S.; Frackelton, Edward C.; Fuchs, Barry; Furlong, Clement E.; Gibson, Quince; Gieger, Christian; Goel, Anuj; Grobbee, Diederik E.; Hastie, Claire; Howard, Philip J.; Huang, Guan-Hua; Johnson, W. Craig; Li, Qing; Kleber, Marcus E.; Klein, Barbara E. K.; Klein, Ronald; Kooperberg, Charles; Ky, Bonnie; LaCroix, Andrea; Lanken, Paul; Lathrop, Mark; Li, Mingyao; Marshall, Vanessa; Melander, Olle; Mentch, Frank D.; Meyer, Nuala J.; Monda, Keri L.; Montpetit, Alexandre; Murugesan, Gurunathan; Nakayama, Karen; Nondahl, Dave; Onipinla, Abiodun; Rafelt, Suzanne; Newhouse, Stephen J.; Otieno, F. George; Patel, Sanjey R.; Putt, Mary E.; Rodriguez, Santiago; Safa, Radwan N.; Sawyer, Douglas B.; Schreiner, Pamela J.; Simpson, Claire; Sivapalaratnam, Suthesh; Srinivasan, Sathanur R.; Suver, Christine; Swergold, Gary; Sweitzer, Nancy K.; Thomas, Kelly A.; Thorand, Barbara; Timpson, Nicholas J.; Tischfield, Sam; Tobin, Martin; Tomaszewski, Maciej; Tomaszweski, Maciej; Verschuren, W. M. Monique; Wallace, Chris; Winkelmann, Bernhard; Zhang, Haitao; Zheng, Dongling; Zhang, Li; Zmuda, Joseph M.; Clarke, Robert; Balmforth, Anthony J.; Danesh, John; Day, Ian N.; Schork, Nicholas J.; de Bakker, Paul I. W.; Delles, Christian; Duggan, David; Hingorani, Aroon D.; Hirschhorn, Joel N.; Hofker, Marten H.; Humphries, Steve E.; Kivimaki, Mika; Lawlor, Debbie A.; Kottke-Marchant, Kandice; Mega, Jessica L.; Mitchell, Braxton D.; Morrow, David A.; Palmen, Jutta; Redline, Susan; Shields, Denis C.; Shuldiner, Alan R.; Sleiman, Patrick M.; Smith, George Davey; Farrall, Martin; Jamshidi, Yalda; Christiani, David C.; Casas, Juan P.; Hall, Alistair S.; Doevendans, Pieter A.; Christie, Jason D.; Berenson, Gerald S.; Murray, Sarah S.; Illig, Thomas; Dorn, Gerald W.; Cappola, Thomas P.; Boerwinkle, Eric; Sever, Peter; Rader, Daniel J.; Reilly, Muredach P.; Caulfield, Mark; Talmud, Philippa J.; Topol, Eric; Engert, James C.; Wang, Kai; Dominiczak, Anna; Hamsten, Anders; Curtis, Sean P.; Silverstein, Roy L.; Lange, Leslie A.; Sabatine, Marc S.; Trip, Mieke; Saleheen, Danish; Peden, John F.; Cruickshanks, Karen J.; März, Winfried; O'Connell, Jeffrey R.; Klungel, Olaf H.; Wijmenga, Cisca; Maitland-van der Zee, Anke Hilse; Schadt, Eric E.; Johnson, Julie A.; Jarvik, Gail P.; Papanicolaou, George J.; Grant, Struan F. A.; Munroe, Patricia B.; North, Kari E.; Samani, Nilesh J.; Koenig, Wolfgang; Gaunt, Tom R.; Anand, Sonia S.; van der Schouw, Yvonne T.; Soranzo, Nicole; FitzGerald, Garret A.; Reiner, Alex; Hegele, Robert A.; Hakonarson, Hakon; Keating, Brendan J.

    2011-01-01

    Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 SNPs across approximately 2000 loci, we evaluated the association of common and

  14. Conflict and the Common Good. Studies in Third World Societies, Publication Number Twenty-Four.

    Science.gov (United States)

    Merrill, Robert S., Ed.; Willner, Dorothy, Ed.

    The fundamental theme of these papers is what constitutes the common good and the issues and problems related to the understanding of that common good. Several anthropologists and a political scientist explore this theme in various geographic settings and from many theoretical and methodological perspectives. Among the countries and cultures…

  15. A comparative neutron activation analysis study of common generic manipulated and reference medicines commercialized in Brazil

    International Nuclear Information System (INIS)

    Leal, A.S.; Menezes, M.A.B.C.; Rodrigues, R.R.; Andonie, O.; Vermaercke, P.; Sneyers, L.

    2008-01-01

    In this work, a comparative study of neutron activation analysis (NAA) was performed by the nuclear institutes: CDTN/CNEN-Brazil, CCHEN-Chile and the SCK.CEN-Belgium aiming to investigate some generic, manipulated and reference medicines largely commercialized in Brazil. Some impurities such as: As, Ba, Br, Ce, Co, Cr, Eu, Fe, Hf, Sb, Sc, Sm, Ti and Zn were found, and the heterogeneity of the samples pointed out the lack of an efficient public system of quality control

  16. A Comprehensive Systematic Study on Thermoresponsive Gels: Beyond the Common Architectures of Linear Terpolymers

    Directory of Open Access Journals (Sweden)

    Anna P. Constantinou

    2017-01-01

    Full Text Available In this study, seven thermoresponsive methacrylate terpolymers with the same molar mass (MM and composition but various architectures were successfully synthesized using group transfer polymerization (GTP. These terpolymers were based on tri(ethylene glycol methyl ether methacrylate (TEGMA, A unit, n-butyl methacrylate (BuMA, B unit, and 2-(dimethylaminoethyl methacrylate (DMAEMA, C unit. Along with the more common ABC, ACB, BAC, and statistical architectures, three diblock terpolymers were also synthesized and investigated for the first time, namely (ABC, A(BC, and B(AC; where the units in the brackets are randomly copolymerized. Two BC diblock copolymers were also synthesized for comparison. Their hydrodynamic diameters and their effective pKas were determined by dynamic light scattering (DLS and hydrogen ion titrations, respectively. The self-assembly behavior of the copolymers was also visualized by transmission electron microscopy (TEM. Both dilute and concentrated aqueous copolymer solutions were extensively studied by visual tests and their cloud points (CP and gel points were determined. It is proven that the aqueous solution properties of the copolymers, with specific interest in their thermoresponsive properties, are influenced by the architecture, with the ABC and A(BC ones to show clear sol-gel transition.

  17. Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2.

    Science.gov (United States)

    Kaserer, Teresa; Temml, Veronika; Kutil, Zsofia; Vanek, Tomas; Landa, Premysl; Schuster, Daniela

    2015-01-01

    Computational methods can be applied in drug development for the identification of novel lead candidates, but also for the prediction of pharmacokinetic properties and potential adverse effects, thereby aiding to prioritize and identify the most promising compounds. In principle, several techniques are available for this purpose, however, which one is the most suitable for a specific research objective still requires further investigation. Within this study, the performance of several programs, representing common virtual screening methods, was compared in a prospective manner. First, we selected top-ranked virtual screening hits from the three methods pharmacophore modeling, shape-based modeling, and docking. For comparison, these hits were then additionally predicted by external pharmacophore- and 2D similarity-based bioactivity profiling tools. Subsequently, the biological activities of the selected hits were assessed in vitro, which allowed for evaluating and comparing the prospective performance of the applied tools. Although all methods performed well, considerable differences were observed concerning hit rates, true positive and true negative hits, and hitlist composition. Our results suggest that a rational selection of the applied method represents a powerful strategy to maximize the success of a research project, tightly linked to its aims. We employed cyclooxygenase as application example, however, the focus of this study lied on highlighting the differences in the virtual screening tool performances and not in the identification of novel COX-inhibitors. Copyright © 2015 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

  18. Bibliography of studies on hybrid zones of the common shrew chromosome races distributed in Russia

    Directory of Open Access Journals (Sweden)

    Rena Nadjafova

    2013-11-01

    Full Text Available The common shrew, Sorex araneus Linnaeus, 1758, has become a model species for cytogenetical and evolutionary studies after discovery of extraordinary Robertsonian polymorphism at the within-species level. Development of differential staining techniques (Q-, R-and G-banding made it possible to identify the chromosomal arms and their combination in racial karyotypes. Entering into contact with each other, the chromosomal races might form hybrid zones which represent a great interest for understanding of the process of speciation. Until recently all known hybrid zones of S. araneus were localized in Western Europe and only one was identified in Siberia (Russia between Novosibirsk and Tomsk races (Aniskin and Lukianova 1989, Searle and Wójcik 1998, Polyakov et al. 2011. However, rapidly growing number of reports on discovery of interracial hybrid zones of Sorex araneus in the European part of Russia and neighboring territories appeared lately. The aim of the present work is to compile the bibliography of all studies covering this topic regardless of the original language and the publishing source which hopefully could make research data more accessible to international scientists.It could also be a productive way to save current history of Sorex araneus researches in full context of the ISACC (International Sorex araneus Cytogenetics Committee heritage (Searle et al. 2007, Zima 2008.

  19. Development of an Advanced Digital Reactor Protection System Using Diverse Dual Processors to Prevent Common-Mode Failure

    International Nuclear Information System (INIS)

    Shin, Hyun Kook; Nam, Sang Ku; Sohn, Se Do; Chang, Hoon Seon

    2003-01-01

    The advanced digital reactor protection system (ADRPS) with diverse dual processors has been developed to prevent common-mode failure (CMF). The principle of diversity is applied to both hardware design and software design. For hardware diversity, two different types of CPUs are used for the bistable processor and local coincidence logic (LCL) processor. The Versa Module Eurocard-based single board computers are used for the CPU hardware platforms. The QNX operating system and the VxWorks operating system were selected for software diversity. Functional diversity is also applied to the input and output modules, and to the algorithm in the bistable processors and LCL processors. The characteristics of the newly developed digital protection system are described together with the preventive capability against CMF. Also, system reliability analysis is discussed. The evaluation results show that the ADRPS has a good preventive capability against the CMF and is a highly reliable reactor protection system

  20. A Common Software Configuration Management System for CERN SPS and LEP Accelerators and Technical Services

    CERN Document Server

    Hatziangeli, Eugenia; Bragg, A E; Ninin, P; Patino, J; Sobczak, H

    1999-01-01

    Software configuration management activities are crucial to assure the integrity of current operational and the quality of new software either being developed at CERN or outsourced. The functionality of the present management system became insufficient with large maintenance overheads. In order to improve our situation, a new software configuration management system has been set up. It is based on Razor, a commercial tool, which supports the management of file versions and operational software releases, along with integrated problem reporting capabilities. In addition to the basic tool functionality, automated procedures were custom made, for the installation and distribution of operational software. Policies were developed and applied over the software development life cycle to provide visibility and control. The system ensures that, at all times, the status and location of all deliverable versions are known, the state of shared objects is carefully controlled and unauthorised changes prevented. It provides ...

  1. AEROMETRIC INFORMATION RETRIEVAL SYSTEM (AIRS) -GEOGRAPHIC, COMMON, AND MAINTENANCE SUBSYSTEM (GCS)

    Science.gov (United States)

    Aerometric Information Retrieval System (AIRS) is a computer-based repository of information about airborne pollution in the United States and various World Health Organization (WHO) member countries. AIRS is administered by the U.S. Environmental Protection Agency, and runs on t...

  2. Nonlinear Parameter Estimation in Microbiological Degradation Systems and Statistic Test for Common Estimation

    DEFF Research Database (Denmark)

    Sommer, Helle Mølgaard; Holst, Helle; Spliid, Henrik

    1995-01-01

    Three identical microbiological experiments were carried out and analysed in order to examine the variability of the parameter estimates. The microbiological system consisted of a substrate (toluene) and a biomass (pure culture) mixed together in an aquifer medium. The degradation of the substrate...

  3. Finding Common Ground in Pension Reform: Lessons from the Washington State Pension System

    Science.gov (United States)

    Goldhaber, Dan; Grout, Cyrus

    2014-01-01

    As states and localities across the nation consider the tradeoffs between defined benefit (DB) and defined contribution (DC) pension systems, it is important to gain insight into what implications pension reforms might have on workforce composition and teachers' retirement savings behavior. Moreover, it is also important to consider that…

  4. Analysis of Ocular Firework-Related Injuries and Common Eye Traumata: a 5-year Clinical Study.

    Science.gov (United States)

    Frimmel, S; Theusinger, O M; Kniestedt, C

    2017-04-01

    Background A comparative study of eye injuries related to fireworks or acts of violence around New Year's Eve and the Swiss National Day on August 1st. The two groups were compared with respect to the overall numbers of eye accidents within the period of review. Patients and Methods Retrospective analysis of emergency consultations at the Department of Ophthalmology, University Hospital Zurich with eye accidents around the Swiss National Day on August 1st and New Year's Eve over the last 5 years. Two subgroups were formed: (1) Firework-related eye traumata, (2) Eye injuries due to acts of violence. The groups were analysed by age, gender, active participant or bystander, eye involved, severity of trauma (from clinical findings), surgical interventions, time of follow-up and visits, visual acuity and outcome. Results The study included 97 patients (100 eyes) with 74 male (76 %) and 23 female (24 %) victims. After filtering out 67 common traumata cases (all unilateral), 17 patients (18 eyes) with firework-related injuries and 13 patients (15 eyes) with damage due to an act of violence remained. Firework injuries accounted for 18 % of cases (65 % men); eye injuries caused by an act of violence accounted for 15 % of cases (92 % men). In the fireworks group, women were significantly older than men (mean age men 32 ± 14 years versus women 38 ± 16 years, p = 0.002). 65 % of cases were bystanders. The two subgroups contained 30 patients (33 eyes) with 22 left eyes (67 %, p fireworks group (28 %), than in the violence group (13 %). 87 % of the victims in the group of common traumata were mild trauma, 10 % moderate and 3 % severe. In the fireworks group the distribution was 53 % mild, 12 % moderate and 35 % severe, in the violence group 46 %, 23 % and 31 % respectively. Severe trauma cases occurred significantly more often around the New Year, with 36 % versus August 1st with 18 % (p = 0.0028). They are more often

  5. A cross-cultural study of the structure of comorbidity among common psychopathological syndromes in the general health care setting

    NARCIS (Netherlands)

    Krueger, RF; Chentsova-Dutton, YE; Markon, KE; Goldberg, D; Ormel, J

    This study presents analyses of 7 common psychopathological syndromes in the World Health Organization (WHO) Collaborative Study of Psychological Problems in General Health Care (T. B. Ustun & N. Sartorius, 1995). Data on depression, somatization, hypochondriasis, neurasthenia, anxious worry,

  6. Syndromic management of common illnesses in hospitalized children and neonates: a cost identification study.

    Science.gov (United States)

    Daga, Subhashchandra; Verma, Bela; Shahane, Satish; Janged, Sunil; Vachagan, M Mani

    2010-12-01

    To find out drug treatment cost per illness per patient admitted to pediatric ward. Patients admitted to pediatric ward over a period of 1 year were studied without exclusions. Following presentations were studied: fever, rapid breathing, diarrhea, severe malnutrition and neurological problems such as altered conscious level or convulsion. In this prospective observational study, patients with other problems were excluded. The subjects were also categorized as critically sick, sick and stable. Expenditure on medicines was calculated individually for each patient. Total expenditure, average cost and illness-wise cost were subsequently derived. Management of illnesses was on the lines of existing guidelines of our center. Sick newborns or newborns referred for special care were separately studied. Following outcome variables were studied: death or discharge, length of hospital stay and the day on which symptomatic relief was noted. 774 children and 141 newborns were studied. 25(3.2%) died. Presenting features were as follows: fever-568 (73.4%), rapid breathing-175 (22.6%), diarrhea-145 (18.7%), mild-moderate malnutrition-278 (35.8%), severe malnutrition-111 (14.3%) and neurological problems-41 (5.3%). Category-wise distribution was as follows: critically sick-89 (11.3%), sick-188 (24.3%) and stable-497 (46.2%). Average hospital stay was 7.1 days and symptomatic relief was experienced by day three in 77.7% cases. Average cost of medicines per patient was INR-167.8 (USD-4.2), 173 patients required oxygen and mean expenditure on oxygen was INR-310 (USD-8) and 68 patients required inotropes with a mean expenditure of INR-198 (USD-5). Of the 141 newborns admitted, 20(14.1%) died. Mean hospital stay was 9.8 days and average cost of drug treatment was INR-790 (USD-20) in newborns. This cost analysis study presents drug treatment costs for common illnesses at a referral centre in a developing country. It gives an option to choose drugs for an optimum mix of cost and

  7. Common variant of ALPK1 is not associated with gout: a replication study.

    Science.gov (United States)

    Chiba, Toshinori; Matsuo, Hirotaka; Sakiyama, Masayuki; Nakayama, Akiyoshi; Shimizu, Seiko; Wakai, Kenji; Suma, Shino; Nakashima, Hiroshi; Sakurai, Yutaka; Shimizu, Toru; Ichida, Kimiyoshi; Shinomiya, Nariyoshi

    2015-01-01

    Gout is one of the most kinds of common inflammatory arthritis as a consequence of hyperuricemia. Alpha-protein kinase 1 (ALPK1) gene locates in a gout-susceptibility locus on chromosome 4q21-31, and encodes ALPK1 protein which plays a pivotal role in the phosphorylation of myosin 1. In the previous genetic study of Taiwanese populations, 3 single nucleotide polymorphisms (SNPs), rs11726117, rs231247 and rs231253, in ALPK1 gene were reported to have a significant association with gout. However, no replication study has been performed to confirm this association. Therefore, we first conducted a replication study with clinically defined gout patients in a different population. Linkage disequilibrium (LD) analyzes of the 3 SNPs in ALPK1 revealed that these SNPs are in strong LD in a Japanese population. Among the 3 SNPs of ALPK1, rs11726117 (M861T) is the only missense SNP. Therefore, rs11726117 was genotyped in a Japanese population of 903 clinically defined gout cases and 1,302 controls, and was evaluated for a possible association with gout. The minor allele frequencies of rs11726117 were 0.26 and 0.25 in the case and control groups, respectively. The association analysis has not detected a significant association between rs11726117 and gout susceptibility in a Japanese population (p = 0.44). Because ABCG2, a major causative gene for gout, also locates in the gout-susceptibility locus on chromosome 4q, these findings suggest that among genes in a gout-susceptibility locus, not ALPK1 but ABCG2 could be important as a gout-susceptible gene.

  8. Validation of commonly used reference genes for sleep-related gene expression studies

    Directory of Open Access Journals (Sweden)

    Castro Rosa MRPS

    2009-05-01

    Full Text Available Abstract Background Sleep is a restorative process and is essential for maintenance of mental and physical health. In an attempt to understand the complexity of sleep, multidisciplinary strategies, including genetic approaches, have been applied to sleep research. Although quantitative real time PCR has been used in previous sleep-related gene expression studies, proper validation of reference genes is currently lacking. Thus, we examined the effect of total or paradoxical sleep deprivation (TSD or PSD on the expression stability of the following frequently used reference genes in brain and blood: beta-actin (b-actin, beta-2-microglobulin (B2M, glyceraldehyde-3-phosphate dehydrogenase (GAPDH, and hypoxanthine guanine phosphoribosyl transferase (HPRT. Results Neither TSD nor PSD affected the expression stability of all tested genes in both tissues indicating that b-actin, B2M, GAPDH and HPRT are appropriate reference genes for the sleep-related gene expression studies. In order to further verify these results, the relative expression of brain derived neurotrophic factor (BDNF and glycerol-3-phosphate dehydrogenase1 (GPD1 was evaluated in brain and blood, respectively. The normalization with each of four reference genes produced similar pattern of expression in control and sleep deprived rats, but subtle differences in the magnitude of expression fold change were observed which might affect the statistical significance. Conclusion This study demonstrated that sleep deprivation does not alter the expression stability of commonly used reference genes in brain and blood. Nonetheless, the use of multiple reference genes in quantitative RT-PCR is required for the accurate results.

  9. Common effects of amnestic mild cognitive impairment on resting-state connectivity across four independent studies

    Directory of Open Access Journals (Sweden)

    Angela eTam

    2015-12-01

    Full Text Available Resting-state functional connectivity is a promising biomarker for Alzheimer’s disease. However, previous resting-state functional magnetic resonance imaging studies in Alzheimer’s disease and amnestic mild cognitive impairment (aMCI have shown limited reproducibility as they have had small sample sizes and substantial variation in study protocol. We sought to identify functional brain networks and connections that could consistently discriminate normal aging from aMCI despite variations in scanner manufacturer, imaging protocol, and diagnostic procedure. We therefore combined four datasets collected independently, including 112 healthy controls and 143 patients with aMCI. We systematically tested multiple brain connections for associations with aMCI using a weighted average routinely used in meta-analyses. The largest effects involved the superior medial frontal cortex (including the anterior cingulate, dorsomedial prefrontal cortex, striatum, and middle temporal lobe. Compared with controls, patients with aMCI exhibited significantly decreased connectivity between default mode network nodes and between regions of the cortico-striatal-thalamic loop. Despite the heterogeneity of methods among the four datasets, we identified common aMCI-related connectivity changes with small to medium effect sizes and sample size estimates recommending a minimum of 140 to upwards of 600 total subjects to achieve adequate statistical power in the context of a multisite study with 5-10 scanning sites and about 10 subjects per group and per site. If our findings can be replicated and associated with other established biomarkers of Alzheimer’s disease (e.g. amyloid and tau quantification, then these functional connections may be promising candidate biomarkers for Alzheimer’s disease.

  10. Transforming library service through information commons case studies for the digital age

    CERN Document Server

    Bailey, D Russell

    2008-01-01

    The Information Commons (IC) strives to unite all the facts and figures of the world into a resource available to everyone. Many academic libraries are considering implementing an information commons model that reflects the contemporary way patrons use resources. Others plan on revitalizing their libraries through configurations that easily integrate research, teaching, and learning with a digital focus. This invaluable guide provides the "how-to" information necessary for institutions considering the development of an information commons. Offering plain-speaking advice on what works, expert

  11. Wnt and lithium: a common destiny in the therapy of nervous system pathologies?

    Science.gov (United States)

    Meffre, Delphine; Grenier, Julien; Bernard, Sophie; Courtin, Françoise; Dudev, Todor; Shackleford, Ghjuvan'Ghjacumu; Jafarian-Tehrani, Mehrnaz; Massaad, Charbel

    2014-04-01

    Wnt signaling is required for neurogenesis, the fate of neural progenitors, the formation of neuronal circuits during development, neuron positioning and polarization, axon and dendrite development and finally for synaptogenesis. This signaling pathway is also implicated in the generation and differentiation of glial cells. In this review, we describe the mechanisms of action of Wnt signaling pathways and their implication in the development and correct functioning of the nervous system. We also illustrate how a dysregulated Wnt pathway could lead to psychiatric, neurodegenerative and demyelinating pathologies. Lithium, used for the treatment of bipolar disease, inhibits GSK3β, a central enzyme of the Wnt/β-catenin pathway. Thus, lithium could, to some extent, mimic Wnt pathway. We highlight the possible dialogue between lithium therapy and modulation of Wnt pathway in the treatment of the diseases of the nervous system.

  12. The Role of Sharia Judges in Indonesia: Between the Common Law and the Civil Law Systems

    OpenAIRE

    Alfitri, Alfitri

    2017-01-01

    This article seeks to analyse the role of Religious Courts' (Pengadilan Agama or PA) Judges in the formation of Islamic law in Indonesia. As part of the civil legal system, PA Judges are bound by legal provisions in handling legal disputes in court. They must apply the applicable legal provisions to decide upon a case. This condition can also be understood from the aspect of appointment of judges in Indonesia, including PA Judges, which is conducted not through professional career path as in ...

  13. Environmental Assessment Distributed Common Ground System (DCGS) Operations Facility, Beale Air Force Base, California

    Science.gov (United States)

    2014-07-01

    corner of 10th and B Streets. The new building would be connected to existing electrical, communication, natural gas, water, and sanitary sewer...would be connected to existing electrical, communication, natural gas, water, and sanitary sewer systems and lines on the project site. The areas of... clay loam starting at approximately 6 inches, to clay at 19 inches, to a duripan from 20 to 40 inches. The Redding soils are moderately deep to

  14. Variations of the aortic arch - a study on the most common branching patterns

    Energy Technology Data Exchange (ETDEWEB)

    Muller, Marguerite; Schmitz, Bernd L; Schick, Melanie; Schloetzer, Wiebke (Dept. of Diagnostic and Interventional Radiology, Section Neuroradiology, Univ. Ulm (Germany)), email: marguerite.mueller@uni-ulm.de; Pauls, Sandra (Dept. of Diagnostic and Interventional Radiology, Univ. Ulm (Germany)); Roehrer, Stefan; Kapapa, Thomas (Dept. of Neurosurgery, Univ. Ulm (Germany))

    2011-09-15

    Background: Anatomical variants of the aortic arch and its branching patterns often appear as an incidental finding during routine computed tomography (CT) scanning. These variations can be of relevance when performing angiography or endovascular interventions and may cause symptoms such as dysphagia. Purpose: To analyze common anatomical variations found within the arteries originating from the aortic arch in patients using contrast CT imaging techniques. Material and Methods: A total of 2033 contrast CT scans were analyzed. To obtain a truly representative sample, cases were chosen from different hospital departments without previous knowledge of the patient history. Results: The total percentage of variations within the analyzed patients was 13.3%. In 8.0% a truncus bicaroticus was found. 4.2% of the patients showed a left vertebral artery originating directly from the aortic arch, mostly proximal, and in 1 case distal to the left subclavian artery. In 1.0% we found an aberrant right subclavian artery. We also found a single case of a right descending aortic arch. Conclusion: Variations of the aortic arch and its branching are frequently found, mostly as an incidental finding during routine diagnostic scanning. A contrast-enhanced CT scan is a good method with which to study the aortic arch and its associated branching pattern

  15. Elemental analysis of edible grains by micro-PIXE: Common buckwheat case study

    Energy Technology Data Exchange (ETDEWEB)

    Vogel-Mikus, K. [Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, SI-1000 Ljubljana (Slovenia); Pelicon, P.; Vavpetic, P. [Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana (Slovenia); Kreft, I. [Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, SI-1000 Ljubljana (Slovenia)], E-mail: ivan.kreft@guest.arnes.si; Regvar, M. [Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, SI-1000 Ljubljana (Slovenia)

    2009-09-01

    The aim of this study was the adaptation of the micro-PIXE method for analysis of nutritionally relevant heavy elements in different tissues of the grain of common buckwheat (Fagopyrum esculentum), as a representative nutritionally interesting grain food source. At 57% of the buckwheat grain biomass, the endosperm was a modest nutrient source when compared to the cotyledons, at 17% of the biomass. These latter contained high concentrations of trace elements, representing 91% of the total grain Zn, 87% for P, 70% for S, 62% for Mg, 60% for K, 54% for Cu, 53% for Mn and 35% for Fe. The husk provided storage for 85% of the total Ca, 84% for Al, 83% for Si, 76% for Cl, 69% for Ti and 46% for Fe. Knowledge on these preferential elemental constitutions of the different grain tissues makes the possibility of designing target products with nutritionally optimal constitution more feasible. These data represent a basis for a more targeted approach to nutritional improvement of grains intended for human consumption.

  16. Elemental analysis of edible grains by micro-PIXE: Common buckwheat case study

    International Nuclear Information System (INIS)

    Vogel-Mikus, K.; Pelicon, P.; Vavpetic, P.; Kreft, I.; Regvar, M.

    2009-01-01

    The aim of this study was the adaptation of the micro-PIXE method for analysis of nutritionally relevant heavy elements in different tissues of the grain of common buckwheat (Fagopyrum esculentum), as a representative nutritionally interesting grain food source. At 57% of the buckwheat grain biomass, the endosperm was a modest nutrient source when compared to the cotyledons, at 17% of the biomass. These latter contained high concentrations of trace elements, representing 91% of the total grain Zn, 87% for P, 70% for S, 62% for Mg, 60% for K, 54% for Cu, 53% for Mn and 35% for Fe. The husk provided storage for 85% of the total Ca, 84% for Al, 83% for Si, 76% for Cl, 69% for Ti and 46% for Fe. Knowledge on these preferential elemental constitutions of the different grain tissues makes the possibility of designing target products with nutritionally optimal constitution more feasible. These data represent a basis for a more targeted approach to nutritional improvement of grains intended for human consumption.

  17. Variations of the aortic arch - a study on the most common branching patterns

    International Nuclear Information System (INIS)

    Muller, Marguerite; Schmitz, Bernd L; Schick, Melanie; Schloetzer, Wiebke; Pauls, Sandra; Roehrer, Stefan; Kapapa, Thomas

    2011-01-01

    Background: Anatomical variants of the aortic arch and its branching patterns often appear as an incidental finding during routine computed tomography (CT) scanning. These variations can be of relevance when performing angiography or endovascular interventions and may cause symptoms such as dysphagia. Purpose: To analyze common anatomical variations found within the arteries originating from the aortic arch in patients using contrast CT imaging techniques. Material and Methods: A total of 2033 contrast CT scans were analyzed. To obtain a truly representative sample, cases were chosen from different hospital departments without previous knowledge of the patient history. Results: The total percentage of variations within the analyzed patients was 13.3%. In 8.0% a truncus bicaroticus was found. 4.2% of the patients showed a left vertebral artery originating directly from the aortic arch, mostly proximal, and in 1 case distal to the left subclavian artery. In 1.0% we found an aberrant right subclavian artery. We also found a single case of a right descending aortic arch. Conclusion: Variations of the aortic arch and its branching are frequently found, mostly as an incidental finding during routine diagnostic scanning. A contrast-enhanced CT scan is a good method with which to study the aortic arch and its associated branching pattern

  18. First-principles study of the formation of glycine-producing radicals from common interstellar species

    Science.gov (United States)

    Sato, Akimasa; Kitazawa, Yuya; Ochi, Toshiro; Shoji, Mitsuo; Komatsu, Yu; Kayanuma, Megumi; Aikawa, Yuri; Umemura, Masayuki; Shigeta, Yasuteru

    2018-03-01

    Glycine, the simplest amino acid, has been intensively searched for in molecular clouds, and the comprehensive clarification of the formation path of interstellar glycine is now imperative. Among all the possible glycine formation pathways, we focused on the radical pathways revealed by Garrod (2013). In the present study, we have precisely investigated all the chemical reaction steps related to the glycine formation processes based on state-of-the-art density functional theory (DFT) calculations. We found that two reaction pathways require small activation barriers (ΔE‡ ≤ 7.75 kJ mol-1), which demonstrates the possibility of glycine formation even at low temperatures in interstellar space if the radical species are generated. The origin of carbon and nitrogen in the glycine backbone and their combination patterns are further discussed in relation to the formation mechanisms. According to the clarification of the atomic correspondence between glycine and its potential parental molecules, it is shown that the nitrogen and two carbons in the glycine can originate in three common interstellar molecules, methanol, hydrogen cyanide, and ammonia, and that the source molecules of glycine can be described by any of their combinations. The glycine formation processes can be categorized into six patterns. Finally, we discussed two other glycine formation pathways expected from the present DFT calculation results.

  19. A study of photon interaction parameters in some commonly used solvents

    International Nuclear Information System (INIS)

    Singh, Tejbir; Kaur, Paramjeet; Singh, Parjit S

    2007-01-01

    Various parameters of dosimetric interest such as mass attenuation coefficients, effective atomic numbers and electron densities of some commonly used solvents such as acetonitrile (C 4 H 3 N), butanol (C 4 H 9 OH), chlorobenzene (C 6 H 5 Cl), diethylether (C 4 H 10 O), ethanol (C 2 H 5 OH), methanol (CH 3 OH), propanol (C 3 H 7 OH) and water (H 2 O) were computed in the wide energy range of 10 keV-100 GeV. A comparative study of two different methods used to compute effective atomic numbers has been done. It is observed that in the intermediate energy region (0.1-5 MeV), the mass attenuation coefficient values becomes almost the same for all the solvents, and the effective atomic number and electron density show almost constant values, whereas significant variation is observed in both lower (10-100 keV) and higher (5 MeV-100 GeV) energy regions for all the solvents, which may be due to the dominance of different partial interaction processes in different energy regions

  20. Effect of infrastructure design on commons dilemmas in social-ecological system dynamics.

    Science.gov (United States)

    Yu, David J; Qubbaj, Murad R; Muneepeerakul, Rachata; Anderies, John M; Aggarwal, Rimjhim M

    2015-10-27

    The use of shared infrastructure to direct natural processes for the benefit of humans has been a central feature of human social organization for millennia. Today, more than ever, people interact with one another and the environment through shared human-made infrastructure (the Internet, transportation, the energy grid, etc.). However, there has been relatively little work on how the design characteristics of shared infrastructure affect the dynamics of social-ecological systems (SESs) and the capacity of groups to solve social dilemmas associated with its provision. Developing such understanding is especially important in the context of global change where design criteria must consider how specific aspects of infrastructure affect the capacity of SESs to maintain vital functions in the face of shocks. Using small-scale irrigated agriculture (the most ancient and ubiquitous example of public infrastructure systems) as a model system, we show that two design features related to scale and the structure of benefit flows can induce fundamental changes in qualitative behavior, i.e., regime shifts. By relating the required maintenance threshold (a design feature related to infrastructure scale) to the incentives facing users under different regimes, our work also provides some general guidance on determinants of robustness of SESs under globalization-related stresses.

  1. Complications after common sheath reimplantation in pediatric patients with complicated duplex system.

    Science.gov (United States)

    Lee, Yong Seung; Im, Young Jae; Shin, Sang Hee; Bascuna, Rosito T; Ha, Ji Yong; Han, Sang Won

    2015-02-01

    To report our experience of common sheath reimplantation (CSR) for ectopic ureterocele (EU) combined with ureteral duplication, describing success rates and postoperative complications, along with risk factors for developing postoperative incontinence. When the upper tract approach is not indicated in patients with EU, a bladder-level approach, involving either CSR or total reconstruction, is the remaining option. However, concerns exist about the high morbidity of bladder-level approaches. We retrospectively examined the postoperative results of 39 patients who underwent CSR between January 2001 and December 2012. Risk factors for the development of postoperative incontinence and decreases in differential renal function (DRF) were additionally analyzed. The median age at operation was 16.5 months. After CSR, upper urinary tract dilatation decreased in 36 patients (92.3%). During a median follow-up of 75.9 months, an additional operation was required in 7 patients (17.9%). Postoperative incontinence developed in 3 patients (7.7%). Median preoperative DRF was significantly lower in the postoperative incontinence group (P = .004). DRF decreased postoperatively in 5 of 36 patients (13.9%). No preoperative factors were related to the decrease in DRF. No patient developed hypertension or proteinuria. CSR decompressed the upper urinary tract effectively in our EU patients. Postoperative incontinence does not seem to be related to operation factors, but with preoperative DRF. When the upper tract approach is not indicated, CSR is a reasonable alternative. Total reconstruction is unnecessary as the remnant upper pole kidney after CSR does not lead to complications. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Oxygen Compatibility of Brass-Filled PTFE Compared to Commonly Used Fluorinated Polymers for Oxygen Systems

    Science.gov (United States)

    Herald, Stephen D.; Frisby, Paul M.; Davis, Samuel Eddie

    2009-01-01

    Safe and reliable seal materials for high-pressure oxygen systems sometimes appear to be extinct species when sought out by oxygen systems designers. Materials that seal well are easy to find, but these materials are typically incompatible with oxygen, especially in cryogenic liquid form. This incompatibility can result in seals that leak, or much worse, seals that easily ignite and burn during use. Materials that are compatible with oxygen are easy to find, such as the long list of compatible metals, but these metallic materials are limiting as seal materials. A material that seals well and is oxygen compatible has been the big game in the designer's safari. Scientists at the Materials Combustion Research Facility (MCRF), part of NASA/Marshall Space Flight Center (MSFC), are constantly searching for better materials and processes to improve the safety of oxygen systems. One focus of this effort is improving the characteristics of polymers used in the presence of an oxygen enriched environment. Very few systems can be built which contain no polymeric materials; therefore, materials which have good impact resistance, low heat of combustion, high auto-ignition temperature and that maintain good mechanical properties are essential. The scientists and engineers at the Materials Combustion Research Facility, in cooperation with seal suppliers, are currently testing a new formulation of polytetrafluoroethylene (PTFE) with Brass filler. This Brass-filled PTFE is showing great promise as a seal and seat material for high pressure oxygen systems. Early research has demonstrated very encouraging results, which could rank this material as one of the best fluorinated polymers ever tested. This paper will compare the data obtained for Brass-filled PTFE with other fluorinated polymers, such as TFE-Teflon (PTFE) , Kel-F 81, Viton A, Viton A-500, Fluorel , and Algoflon . A similar metal filled fluorinated polymer, Salox-M , was tested in comparison to Brass-filled PTFE to

  3. Tokamak reactor systems studies

    International Nuclear Information System (INIS)

    1992-01-01

    A summary of work completed on the ARIES project during this report period is given. The main areas of effort were: neutronics, shield optimization and design, safety, systems, startup and shutdown, and ripple loss

  4. Prokaryotic regulatory systems biology: Common principles governing the functional architectures of Bacillus subtilis and Escherichia coli unveiled by the natural decomposition approach.

    Science.gov (United States)

    Freyre-González, Julio A; Treviño-Quintanilla, Luis G; Valtierra-Gutiérrez, Ilse A; Gutiérrez-Ríos, Rosa María; Alonso-Pavón, José A

    2012-10-31

    Escherichia coli and Bacillus subtilis are two of the best-studied prokaryotic model organisms. Previous analyses of their transcriptional regulatory networks have shown that they exhibit high plasticity during evolution and suggested that both converge to scale-free-like structures. Nevertheless, beyond this suggestion, no analyses have been carried out to identify the common systems-level components and principles governing these organisms. Here we show that these two phylogenetically distant organisms follow a set of common novel biologically consistent systems principles revealed by the mathematically and biologically founded natural decomposition approach. The discovered common functional architecture is a diamond-shaped, matryoshka-like, three-layer (coordination, processing, and integration) hierarchy exhibiting feedback, which is shaped by four systems-level components: global transcription factors (global TFs), locally autonomous modules, basal machinery and intermodular genes. The first mathematical criterion to identify global TFs, the κ-value, was reassessed on B. subtilis and confirmed its high predictive power by identifying all the previously reported, plus three potential, master regulators and eight sigma factors. The functionally conserved cores of modules, basal cell machinery, and a set of non-orthologous common physiological global responses were identified via both orthologous genes and non-orthologous conserved functions. This study reveals novel common systems principles maintained between two phylogenetically distant organisms and provides a comparison of their lifestyle adaptations. Our results shed new light on the systems-level principles and the fundamental functions required by bacteria to sustain life. Copyright © 2012 Elsevier B.V. All rights reserved.

  5. Health Sciences Library Support of a University Common Reading Program: A Case Study.

    Science.gov (United States)

    Delwiche, Frances A

    2017-01-01

    Common reading programs have become increasingly popular on college and university campuses as a means for increasing student engagement, retention, and success. This article describes the characteristics, goals, and benefits of common reading programs and provides examples from the literature of academic library involvement in them. Finally, an example is provided of how one academic health sciences library participated in its institution's First-Year Summer Reading program.

  6. Facilitating energy transition through energy commons : An application of socio-ecological systems framework for integrated community energy systems

    NARCIS (Netherlands)

    Acosta, Cristina; Ortega, Mariana; Bunsen, Till; Koirala, B.P.; Ghorbani, A.

    2018-01-01

    Integrated Community Energy Systems (ICES) are an emerging local energy system focusing on the collective use of distributed energy resources (DER). These socio-technical systems (STSs) have a high potential to advance the transition towards socially inclusive, environmentally-friendly energy

  7. Facilitating energy transition through energy commons : An application of socio-ecological systems framework for integrated community energy systems

    NARCIS (Netherlands)

    Acosta, Cristina; Ortega, Mariana; Bunsen, Till; Koirala, Binod Prasad; Ghorbani, Amineh

    2018-01-01

    Integrated Community Energy Systems (ICES) are an emerging local energy system focusing on the collective use of distributed energy resources (DER). These socio-technical systems (STSs) have a high potential to advance the transition towards socially inclusive, environmentally-friendly energy

  8. Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study.

    Science.gov (United States)

    Murray, Anna; Bennett, Claire E; Perry, John R B; Weedon, Michael N; Jacobs, Patricia A; Morris, Danielle H; Orr, Nicholas; Schoemaker, Minouk J; Jones, Michael; Ashworth, Alan; Swerdlow, Anthony J

    2011-01-01

    Women become infertile approximately 10 years before menopause, and as more women delay childbirth into their 30s, the number of women who experience infertility is likely to increase. Tests that predict the timing of menopause would allow women to make informed reproductive decisions. Current predictors are only effective just prior to menopause, and there are no long-range indicators. Age at menopause and early menopause (EM) are highly heritable, suggesting a genetic aetiology. Recent genome-wide scans have identified four loci associated with variation in the age of normal menopause (40-60 years). We aimed to determine whether theses loci are also risk factors for EM. We tested the four menopause-associated genetic variants in a cohort of approximately 2000 women with menopause≤45 years from the Breakthrough Generations Study (BGS). All four variants significantly increased the odds of having EM. Comparing the 4.5% of individuals with the lowest number of risk alleles (two or three) with the 3.0% with the highest number (eight risk alleles), the odds ratio was 4.1 (95% CI 2.4-7.1, P=4.0×10(-7)). In combination, the four variants discriminated EM cases with a receiver operator characteristic area under the curve of 0.6. Four common genetic variants identified by genome-wide association studies, had a significant impact on the odds of having EM in an independent cohort from the BGS. The discriminative power is still limited, but as more variants are discovered they may be useful for predicting reproductive lifespan.

  9. Association of common variants in mismatch repair genes and breast cancer susceptibility: a multigene study

    International Nuclear Information System (INIS)

    Conde, João; Silva, Susana N; Azevedo, Ana P; Teixeira, Valdemar; Pina, Julieta Esperança; Rueff, José; Gaspar, Jorge F

    2009-01-01

    MMR is responsible for the repair of base-base mismatches and insertion/deletion loops. Besides this, MMR is also associated with an anti-recombination function, suppressing homologous recombination. Losses of heterozygosity and/or microsatellite instability have been detected in a large number of skin samples from breast cancer patients, suggesting a potential role of MMR in breast cancer susceptibility. We carried out a hospital-based case-control study in a Caucasian Portuguese population (287 cases and 547 controls) to estimate the susceptibility to non-familial breast cancer associated with some polymorphisms in mismatch repair genes (MSH3, MSH4, MSH6, MLH1, MLH3, PMS1 and MUTYH). Using unconditional logistic regression we found that MLH3 (L844P, G>A) polymorphism GA (Leu/Pro) and AA (Pro/Pro) genotypes were associated with a decreased risk: OR = 0.65 (0.45-0.95) (p = 0.03) and OR = 0.62 (0.41-0.94) (p = 0.03), respectively. Analysis of two-way SNP interaction effects on breast cancer revealed two potential associations to breast cancer susceptibility: MSH3 Ala1045Thr/MSH6 Gly39Glu - AA/TC [OR = 0.43 (0.21-0.83), p = 0.01] associated with a decreased risk; and MSH4 Ala97Thr/MLH3 Leu844Pro - AG/AA [OR = 2.35 (1.23-4.49), p = 0.01], GG/AA [OR = 2.11 (1.12-3,98), p = 0.02], and GG/AG [adjusted OR = 1.88 (1.12-3.15), p = 0.02] all associated with an increased risk for breast cancer. It is possible that some of these common variants in MMR genes contribute significantly to breast cancer susceptibility. However, further studies with a large sample size will be needed to support our results

  10. Genetic variation of piperidine alkaloids in Pinus ponderosa: a common garden study.

    Science.gov (United States)

    Gerson, Elizabeth A; Kelsey, Rick G; St Clair, J Bradley

    2009-02-01

    Previous measurements of conifer alkaloids have revealed significant variation attributable to many sources, environmental and genetic. The present study takes a complementary and intensive, common garden approach to examine genetic variation in Pinus ponderosa var. ponderosa alkaloid production. Additionally, this study investigates the potential trade-off between seedling growth and alkaloid production, and associations between topographic/climatic variables and alkaloid production. Piperidine alkaloids were quantified in foliage of 501 nursery seedlings grown from seed sources in west-central Washington, Oregon and California, roughly covering the western half of the native range of ponderosa pine. A nested mixed model was used to test differences among broad-scale regions and among families within regions. Alkaloid concentrations were regressed on seedling growth measurements to test metabolite allocation theory. Likewise, climate characteristics at the seed sources were also considered as explanatory variables. Quantitative variation from seedling to seedling was high, and regional variation exceeded variation among families. Regions along the western margin of the species range exhibited the highest alkaloid concentrations, while those further east had relatively low alkaloid levels. Qualitative variation in alkaloid profiles was low. All measures of seedling growth related negatively to alkaloid concentrations on a natural log scale; however, coefficients of determination were low. At best, annual height increment explained 19.4 % of the variation in ln(total alkaloids). Among the climate variables, temperature range showed a negative, linear association that explained 41.8 % of the variation. Given the wide geographic scope of the seed sources and the uniformity of resources in the seedlings' environment, observed differences in alkaloid concentrations are evidence for genetic regulation of alkaloid secondary metabolism in ponderosa pine. The theoretical

  11. A multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzers.

    Science.gov (United States)

    Ozarda, Yesim; Ichihara, Kiyoshi; Aslan, Diler; Aybek, Hulya; Ari, Zeki; Taneli, Fatma; Coker, Canan; Akan, Pinar; Sisman, Ali Riza; Bahceci, Onur; Sezgin, Nurzen; Demir, Meltem; Yucel, Gultekin; Akbas, Halide; Ozdem, Sebahat; Polat, Gurbuz; Erbagci, Ayse Binnur; Orkmez, Mustafa; Mete, Nuriye; Evliyaoglu, Osman; Kiyici, Aysel; Vatansev, Husamettin; Ozturk, Bahadir; Yucel, Dogan; Kayaalp, Damla; Dogan, Kubra; Pinar, Asli; Gurbilek, Mehmet; Cetinkaya, Cigdem Damla; Akin, Okhan; Serdar, Muhittin; Kurt, Ismail; Erdinc, Selda; Kadicesme, Ozgur; Ilhan, Necip; Atali, Dilek Sadak; Bakan, Ebubekir; Polat, Harun; Noyan, Tevfik; Can, Murat; Bedir, Abdulkerim; Okuyucu, Ali; Deger, Orhan; Agac, Suret; Ademoglu, Evin; Kaya, Ayşem; Nogay, Turkan; Eren, Nezaket; Dirican, Melahat; Tuncer, GulOzlem; Aykus, Mehmet; Gunes, Yeliz; Ozmen, Sevda Unalli; Kawano, Reo; Tezcan, Sehavet; Demirpence, Ozlem; Degirmen, Elif

    2014-12-01

    A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and to explore sources of variation in reference values, including regionality. Blood samples were collected nationwide in 28 laboratories from the seven regions (≥400 samples/region, 3066 in all). The sera were collectively analyzed in Uludag University in Bursa using Abbott reagents and analyzer. Reference materials were used for standardization of test results. After secondary exclusion using the latent abnormal values exclusion method, RIs were derived by a parametric method employing the modified Box-Cox formula and compared with the RIs by the non-parametric method. Three-level nested ANOVA was used to evaluate variations among sexes, ages and regions. Associations between test results and age, body mass index (BMI) and region were determined by multiple regression analysis (MRA). By ANOVA, differences of reference values among seven regions were significant in none of the 25 analytes. Significant sex-related and age-related differences were observed for 10 and seven analytes, respectively. MRA revealed BMI-related changes in results for uric acid, glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, alanine aminotransferase, and γ-glutamyltransferase. Their RIs were thus derived by applying stricter criteria excluding individuals with BMI >28 kg/m2. Ranges of RIs by non-parametric method were wider than those by parametric method especially for those analytes affected by BMI. With the lack of regional differences and the well-standardized status of test results, the RIs derived from this nationwide study can be used for the entire Turkish population.

  12. CAC on a MAC: setting up a DOD Common Access Card reader on the Macintosh OS X operating system

    OpenAIRE

    Hopfner, Phil

    2006-01-01

    The Naval Postgraduate School, along with many other Department of Defense (DOD) organizations, utilizes the ActivCard USB Common Access Card (CAC) readers. The CAC readers in conjunction with the user's Smart Card enables access to DOD PKI-enabled websites and allows the user to send signed and encrypted email utilizing the DOD Public Key Infrastructure (PKI). Microsoft Windows systems utilize the ActivCard Gold middleware software to enable CAC reader functionality. This software packag...

  13. Macroscopical and microscopical studies of the common bile duct in reindeer (Rangifer tarandus tarandus L

    Directory of Open Access Journals (Sweden)

    Timo Rahko

    1990-08-01

    Full Text Available The histological structure and secretory function of the common bile duct (ductus hepaticus communis has not been previously described in reindeer. Macroscopical studies were thus performed in 25 reindeer to reveal the morphology and topography of the ductus hepaticus communis and adjoining organs. Histologic structure of the common bile duct was investigated in 20 animals. Our studies showed that the ductus hepaticus communis and pancreaticus join about 2 cm before the duodenal opening to form the common duct. The common bile duct is an elastic tube about 3 to 5 cm long and 2 to 3 mm thick partly surrounded by fat and pancreatic tissues. The wall of the duct, being about 1 mm thick by light microscopy, consisted of folded mucosa surrounded by connective tissue fibres and a serosal layer. Distally, also muscular bands were seen. In some areas separate leucocytes and even lymphatic nodules were present. Surprisingly pancreatic acini occurred in certain areas of the wall, even in close contact to subepithelial tissues. Mucosal epithelium consisted of surface and glandular epithelial cells with mucous secretion. Numerous intraepithelial globule leucocytes were identifiable within the lamina epithelialis.Tutkimus yhteisen sappikäytävän rakenteesta porolla.Abstract in Finnish / Yhteenveto: Yhteisen sappikäytävän (ductus hepaticus communis histologista rakennetta ja eritystoimintaa ei ole aikaisemmin kuvattu porolla. Makroskooppisia tutkimuksia suoritettiin 25 porolla yhteisen sappikäytävän rakenteen ja topografian selvittämiseksi. Seinämän histologinen rakenne selvitettiin 20 porolla. Tutkimukset osoittivat, että porolla ductus hepaticus communis ja ductus pancreaticus yhtyvät noin 2 cm ennen ohutsuolta muodostaakseen yhteisen tiehyeen. Ductus hepaticus communis on noin 3-5 cm pitkä ja 2-3 mm:n läpimittainen käytävä. Se on elastinen ja osit-tain rasva- ja haimakudoksen ympäröimä. Seinämä on mikroskooppisesti noin 1 mm paksu

  14. Common-Ground-Type Transformerless Inverters for Single-Phase Solar Photovoltaic Systems

    DEFF Research Database (Denmark)

    Siwakoti, Yam Prasad; Blaabjerg, Frede

    2018-01-01

    This paper proposes a family of novel flying capacitor transformerless inverters for single-phase photovoltaic (PV) systems. Each of the new topologies proposed is based on a flying capacitor principle and requires only four power switches and/or diodes, one capacitor, and a small filter at the o......This paper proposes a family of novel flying capacitor transformerless inverters for single-phase photovoltaic (PV) systems. Each of the new topologies proposed is based on a flying capacitor principle and requires only four power switches and/or diodes, one capacitor, and a small filter...... at the output stage. A simple unipolar sinusoidal pulse width modulation technique is used to modulate the inverter to minimize the switching loss, output current ripple, and the filter requirements. In general, the main advantages of the new inverter topologies are: 1) the negative polarity of the PV...... description of the operating principle with modulation techniques, design guidelines, and comprehensive comparisons is presented to reveal the properties and limitations of each topology in detail. Finally, experimental results of 1-kVA prototypes are presented to prove the concept and theoretical analysis...

  15. MDEP Generic Common Position No DICWG-05. Common position on the treatment of hardware description language (HDL) programmed devices for use in nuclear safety systems

    International Nuclear Information System (INIS)

    2013-01-01

    Following other industries, the nuclear industry developed increasing interest in the use of programmable logic components that are implemented using hardware description language (HDL) such as such as FPGAs, CPLDs or ASICs. HDL programmed devices (HPD) has both characteristics of software and hardware. Therefore applications using HPDs has many similarities with the traditional software (in particular the design may be affected by errors) and characteristics of traditional electronic design (e.g. electronic-level timing and electrical issues). However, due to the unique nature of HPDs, there exist several differences between HPDs and traditional software. Some key differences include: - HPDs use parallel processing with dedicated hardware for each function instead of executing instructions sequentially as in the case of traditional software. - Safety critical software uses imperative languages which specify each instruction of the program whereas HPDs use declarative languages. - The target of software is a microprocessor, which guarantees properties such as memory consistency after each instruction. Such properties are not inherent in HPDs and thus the design process needs different steps to build and guarantee behavioural properties. - Translation of the HDL description to bit-streams in HPDs is much more involved than the translation of source code to binary in software compilation. In the HPD case, this process is not fully automatic, and therefore designer must guide the tools, which may result in undetectable errors. The Digital Instrumentation and Controls Working Group (DICWG) has agreed that a common position on this topic is warranted given the increase of use of Digital I and C in new reactor designs, its safety implications, and the need to develop a common understanding from the perspectives of regulatory authorities. This action follows the DICWG examination of the regulatory requirements of the participating members and of relevant industry

  16. Comparative evaluation of topical Sodium fusidate cream in common pyodermas with topical gentamicin ointment and systemic antibiotics

    Directory of Open Access Journals (Sweden)

    Roy AK

    1996-01-01

    Full Text Available ABSTRACT: One hundred cases of common pyodermas consisting of four groups, namely impetigo, furunculosis and chronic folliculitis were taken. Each group containing twenty five cases were divided again into three subgroups. From each group, 15 were treated with 2 percent Sodium fusidate cream, 5 were with 0.1 percent Gentamycin sulphate cream and the rest 5 with systemic Erythromycin stearate. In the group of Impetigo, Bockhart′s Impetigo and Furunculosis, topical Sodium fusidate cream showed excellent result, better than Gentamycin topical and equal to that of systemic Erythromycin stearate.

  17. Acquired partial lipodystrophy and C3 glomerulopathy: Dysregulation of the complement system as a common mechanism

    Directory of Open Access Journals (Sweden)

    Fernando Corvillo

    2018-05-01

    Full Text Available The activation of the alternative pathway of the complement is involved in the development of several renal diseases, such as atypical haemolytic uraemic syndrome and C3 glomerulopathy. In C3 glomerulopathy, a high percentage of patients have circulating levels of the autoantibody called C3NeF, which causes systemic dysregulation of the complement system. In some cases, the presence of this antibody has been related with abnormalities of adipose tissue, causing acquired partial lipodystrophy (Barraquer–Simons syndrome. Acquired partial lipodystrophy is an extremely rare disorder affecting the distribution of subcutaneous adipose tissue and that mainly onsets during childhood. These patients, in addition to possibly presenting with all the metabolic disorders associated with the adipose tissue defect, present with C3 hypocomplementemia and C3NeF and 25% have developed C3 glomerulopathy. Although it has been known for some time how the dysregulation of the complement system affects the kidneys, it remains unknown how it exactly affects adipose tissue; nevertheless, the relationship is quite clear. In this paper, we describe the connection between the complement system with the biology of the adipose tissue and its pathogenesis reflected from acquired partial lipodystrophy. Resumen: La activación de la vía alternativa del complemento interviene en el desarrollo de varias enfermedades renales, como el síndrome hemolítico urémico atípico o la glomerulopatía C3. En esta última enfermedad un elevado porcentaje de los pacientes presentan niveles circulantes de un autoanticuerpo denominado C3NeF, causante de la desregulación del complemento a nivel sistémico. En ciertos casos, la presencia de este anticuerpo se asocia con alteraciones en el tejido adiposo, causando lipodistrofia parcial adquirida (síndrome de Barraquer-Simons, una enfermedad ultra-rara que afecta a la distribución del tejido adiposo subcutáneo y que comienza principalmente

  18. Development of a Common User Interface for the Launch Decision Support System

    Science.gov (United States)

    Scholtz, Jean C.

    1991-01-01

    The Launch Decision Support System (LDSS) is software to be used by the NASA Test Director (NTD) in the firing room during countdown. This software is designed to assist the NTD with time management, that is, when to resume from a hold condition. This software will assist the NTD in making and evaluating alternate plans and will keep him advised of the existing situation. As such, the interface to this software must be designed to provide the maximum amount of information in the clearest fashion and in a timely manner. This research involves applying user interface guidelines to a mature prototype of LDSS and developing displays that will enable the users to easily and efficiently obtain information from the LDSS displays. This research also extends previous work on organizing and prioritizing human-computer interaction knowledge.

  19. A television/still camera with common optical system for reactor inspection

    International Nuclear Information System (INIS)

    Hughes, G.; McBane, P.

    1976-01-01

    One of the problems of reactor inspection is to obtain permanent high quality records. Video recordings provide a record of poor quality but known content. Still cameras can be used but the frame content is not predictable. Efforts have been made to combine T.V. viewing to align a still camera but a simple combination does not provide the same frame size. The necessity to preset the still camera controls severely restricts the flexibility of operation. A camera has, therefore, been designed which allows a search operation using the T.V. system. When an anomaly is found the still camera controls can be remotely set, an exact record obtained and the search operation continued without removal from the reactor. An application of this camera in the environment of the blanket gas region above the sodium region in PFR at 150 0 C is described

  20. Quantum systems as embarrassed colleagues: what do tax evasion and state tomography have in common?

    Science.gov (United States)

    Ferrie, Chris; Blume-Kohout, Robin

    2011-03-01

    Quantum state estimation (a.k.a. ``tomography'') plays a key role in designing quantum information processors. As a problem, it resembles probability estimation - e.g. for classical coins or dice - but with some subtle and important discrepancies. We demonstrate an improved classical analogue that captures many of these differences: the ``noisy coin.'' Observations on noisy coins are unreliable - much like soliciting sensitive information such as ones tax preparation habits. So, like a quantum system, it cannot be sampled directly. Unlike standard coins or dice, whose worst-case estimation risk scales as 1 / N for all states, noisy coins (and quantum states) have a worst-case risk that scales as 1 /√{ N } and is overwhelmingly dominated by nearly-pure states. The resulting optimal estimation strategies for noisy coins are surprising and counterintuitive. We demonstrate some important consequences for quantum state estimation - in particular, that adaptive tomography can recover the 1 / N risk scaling of classical probability estimation.

  1. VSP - Discussion: The Common Interest on Planning Hulls and Plan for Collaboration Studies between NSWC and KRISO - Washington DC

    Science.gov (United States)

    2016-03-07

    planning hulls and plan for N62909-15-1-2052 collaboration studies between NSWC and KRISO - Washington DC Sb. GRANT NUMBER N62909-15-1-2052 Sc. PROGRAM...be carried out in MASK’s facilities. We discussed common interests on planing hulls, and made plans for collaboration studies between NSWC and KRISO ...Presentation of USV project in KRISO 8/19/2015 (Wed) • Discussion of common interests about planing hu lls • Planning for collaboration studies

  2. Making limb and nadir measurements comparable: A common volume study of PMC brightness observed by Odin OSIRIS and AIM CIPS

    Science.gov (United States)

    Benze, Susanne; Gumbel, Jörg; Randall, Cora E.; Karlsson, Bodil; Hultgren, Kristoffer; Lumpe, Jerry D.; Baumgarten, Gerd

    2018-01-01

    Combining limb and nadir satellite observations of Polar Mesospheric Clouds (PMCs) has long been recognized as problematic due to differences in observation geometry, scattering conditions, and retrieval approaches. This study offers a method of comparing PMC brightness observations from the nadir-viewing Aeronomy of Ice in the Mesosphere (AIM) Cloud Imaging and Particle Size (CIPS) instrument and the limb-viewing Odin Optical Spectrograph and InfraRed Imaging System (OSIRIS). OSIRIS and CIPS measurements are made comparable by defining a common volume for overlapping OSIRIS and CIPS observations for two northern hemisphere (NH) PMC seasons: NH08 and NH09. We define a scattering intensity quantity that is suitable for either nadir or limb observations and for different scattering conditions. A known CIPS bias is applied, differences in instrument sensitivity are analyzed and taken into account, and effects of cloud inhomogeneity and common volume definition on the comparison are discussed. Not accounting for instrument sensitivity differences or inhomogeneities in the PMC field, the mean relative difference in cloud brightness (CIPS - OSIRIS) is -102 ± 55%. The differences are largest for coincidences with very inhomogeneous clouds that are dominated by pixels that CIPS reports as non-cloud points. Removing these coincidences, the mean relative difference in cloud brightness reduces to -6 ± 14%. The correlation coefficient between the CIPS and OSIRIS measurements of PMC brightness variations in space and time is remarkably high, at 0.94. Overall, the comparison shows excellent agreement despite different retrieval approaches and observation geometries.

  3. A comparative study of metal artifacts from common metal orthodontic brackets in magnetic resonance imaging

    International Nuclear Information System (INIS)

    Kajan, Zahra Dalili; Alizadeh, Ahmad; Hemmaty, Yasmin Babael; Roushan, Zahra Atrkar; Khademi, Jalil

    2015-01-01

    This study was performed to compare the metal artifacts from common metal orthodontic brackets in magnetic resonance imaging. A dry mandible with 12 intact premolars was prepared, and was scanned ten times with various types of brackets: American, 3M, Dentaurum, and Masel orthodontic brackets were used, together with either stainless steel (SS) or nickel titanium (NiTi) wires. Subsequently, three different sequences of coronal and axial images were obtained: spin-echo T1-weighted images, fast spin-echo T2-weighted images, and fluid-attenuated inversion recovery images. In each sequence, the two sequential axial and coronal images with the largest signal-void area were selected. The largest diameters of the signal voids in the direction of the X-, Y-, and Z-axes were then measured twice. Finally, the mean linear values associated with different orthodontic brackets were analyzed using one-way analysis of variation, and the results were compared using the independent t-test to assess whether the use of SS or NiTi wires had a significant effect on the images. Statistically significant differences were only observed along the Z-axis among the four different brands of orthodontic brackets with SS wires. A statistically significant difference was observed along all axes among the brackets with NiTi wires. A statistically significant difference was found only along the Z-axis between nickel-free and nickel-containing brackets. With respect to all axes, the 3M bracket was associated with smaller signal-void areas. Overall, the 3M and Dentaurum brackets with NiTi wires induced smaller artifacts along all axes than those with SS wires

  4. A study to enhance medical students’ professional decision-making, using teaching interventions on common medications

    Directory of Open Access Journals (Sweden)

    Jane Wilcock

    2015-06-01

    Full Text Available Aim: To create sustained improvements in medical students’ critical thinking skills through short teaching interventions in pharmacology. Method: The ability to make professional decisions was assessed by providing year-4 medical students at a UK medical school with a novel medical scenario (antenatal pertussis vaccination. Forty-seven students in the 2012 cohort acted as a pretest group, answering a questionnaire on this novel scenario. To improve professional decision-making skills, 48 students from the 2013 cohort were introduced to three commonly used medications, through tutor-led 40-min teaching interventions, among six small groups using a structured presentation of evidence-based medicine and ethical considerations. Student members then volunteered to peer-teach on a further three medications. After a gap of 8 weeks, this cohort (post-test group was assessed for professional decision-making skills using the pretest questionnaire, and differences in the 2-year groups analysed. Results: Students enjoyed presenting on medications to their peers but had difficulty interpreting studies and discussing ethical dimensions; this was improved by contextualising information via patient scenarios. After 8 weeks, most students did not show enhanced clinical curiosity, a desire to understand evidence, or ethical questioning when presented with a novel medical scenario compared to the previous year group who had not had the intervention. Students expressed a high degree of trust in guidelines and expert tutors and felt that responsibility for their own actions lay with these bodies. Conclusion: Short teaching interventions in pharmacology did not lead to sustained improvements in their critical thinking skills in enhancing professional practice. It appears that students require earlier and more frequent exposure to these skills in their medical training.

  5. A study to enhance medical students’ professional decision-making, using teaching interventions on common medications

    Science.gov (United States)

    Wilcock, Jane; Strivens, Janet

    2015-01-01

    Aim To create sustained improvements in medical students’ critical thinking skills through short teaching interventions in pharmacology. Method The ability to make professional decisions was assessed by providing year-4 medical students at a UK medical school with a novel medical scenario (antenatal pertussis vaccination). Forty-seven students in the 2012 cohort acted as a pretest group, answering a questionnaire on this novel scenario. To improve professional decision-making skills, 48 students from the 2013 cohort were introduced to three commonly used medications, through tutor-led 40-min teaching interventions, among six small groups using a structured presentation of evidence-based medicine and ethical considerations. Student members then volunteered to peer-teach on a further three medications. After a gap of 8 weeks, this cohort (post-test group) was assessed for professional decision-making skills using the pretest questionnaire, and differences in the 2-year groups analysed. Results Students enjoyed presenting on medications to their peers but had difficulty interpreting studies and discussing ethical dimensions; this was improved by contextualising information via patient scenarios. After 8 weeks, most students did not show enhanced clinical curiosity, a desire to understand evidence, or ethical questioning when presented with a novel medical scenario compared to the previous year group who had not had the intervention. Students expressed a high degree of trust in guidelines and expert tutors and felt that responsibility for their own actions lay with these bodies. Conclusion Short teaching interventions in pharmacology did not lead to sustained improvements in their critical thinking skills in enhancing professional practice. It appears that students require earlier and more frequent exposure to these skills in their medical training. PMID:26051556

  6. A comparative study of metal artifacts from common metal orthodontic brackets in magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kajan, Zahra Dalili; Alizadeh, Ahmad; Hemmaty, Yasmin Babael; Roushan, Zahra Atrkar; Khademi, Jalil [Guilan University of Medical Sciences, Rasht (Iran, Islamic Republic of)

    2015-09-15

    This study was performed to compare the metal artifacts from common metal orthodontic brackets in magnetic resonance imaging. A dry mandible with 12 intact premolars was prepared, and was scanned ten times with various types of brackets: American, 3M, Dentaurum, and Masel orthodontic brackets were used, together with either stainless steel (SS) or nickel titanium (NiTi) wires. Subsequently, three different sequences of coronal and axial images were obtained: spin-echo T1-weighted images, fast spin-echo T2-weighted images, and fluid-attenuated inversion recovery images. In each sequence, the two sequential axial and coronal images with the largest signal-void area were selected. The largest diameters of the signal voids in the direction of the X-, Y-, and Z-axes were then measured twice. Finally, the mean linear values associated with different orthodontic brackets were analyzed using one-way analysis of variation, and the results were compared using the independent t-test to assess whether the use of SS or NiTi wires had a significant effect on the images. Statistically significant differences were only observed along the Z-axis among the four different brands of orthodontic brackets with SS wires. A statistically significant difference was observed along all axes among the brackets with NiTi wires. A statistically significant difference was found only along the Z-axis between nickel-free and nickel-containing brackets. With respect to all axes, the 3M bracket was associated with smaller signal-void areas. Overall, the 3M and Dentaurum brackets with NiTi wires induced smaller artifacts along all axes than those with SS wires.

  7. A comparative study of metal artifacts from common metal orthodontic brackets in magnetic resonance imaging.

    Science.gov (United States)

    Dalili Kajan, Zahra; Khademi, Jalil; Alizadeh, Ahmad; Babaei Hemmaty, Yasamin; Atrkar Roushan, Zahra

    2015-09-01

    This study was performed to compare the metal artifacts from common metal orthodontic brackets in magnetic resonance imaging. A dry mandible with 12 intact premolars was prepared, and was scanned ten times with various types of brackets: American, 3M, Dentaurum, and Masel orthodontic brackets were used, together with either stainless steel (SS) or nickel titanium (NiTi) wires. Subsequently, three different sequences of coronal and axial images were obtained: spin-echo T1 -weighted images, fast spin-echo T2 -weighted images, and fluid-attenuated inversion recovery images. In each sequence, the two sequential axial and coronal images with the largest signal-void area were selected. The largest diameters of the signal voids in the direction of the X-, Y-, and Z-axes were then measured twice. Finally, the mean linear values associated with different orthodontic brackets were analyzed using one-way analysis of variation, and the results were compared using the independent t-test to assess whether the use of SS or NiTi wires had a significant effect on the images. Statistically significant differences were only observed along the Z-axis among the four different brands of orthodontic brackets with SS wires. A statistically significant difference was observed along all axes among the brackets with NiTi wires. A statistically significant difference was found only along the Z-axis between nickel-free and nickel-containing brackets. With respect to all axes, the 3M bracket was associated with smaller signal-void areas. Overall, the 3M and Dentaurum brackets with NiTi wires induced smaller artifacts along all axes than those with SS wires.

  8. Effects of Commonly Used Pesticides in China on the Mitochondria and Ubiquitin-Proteasome System in Parkinson’s Disease

    OpenAIRE

    Chen, Tingting; Tan, Jieqiong; Wan, Zhengqing; Zou, Yongyi; Kessete Afewerky, Henok; Zhang, Zhuohua; Zhang, Tongmei

    2017-01-01

    Evidence continues to accumulate that pesticides are the leading candidates of environmental toxins that may contribute to the pathogenesis of Parkinson’s disease. The mechanisms, however, remain largely unclear. According to epidemiological studies, we selected nine representative pesticides (paraquat, rotenone, chlorpyrifos, pendimethalin, endosulfan, fenpyroximate, tebufenpyrad, trichlorphon and carbaryl) which are commonly used in China and detected the effects of the pesticides on mitoch...

  9. Phase Control of Ultradian Feeding Rhythms in the Common Vole (Microtus arvalis) : The Roles of Light and the Circadian System

    NARCIS (Netherlands)

    Gerkema, Menno P.; Daan, Serge; Wilbrink, Marieke; Hop, Martina W.; van der Leest, Floris

    1993-01-01

    In their ultradian (2- to 3-hr) feeding rhythm, common voles show intraindividual synchrony from day to day, as well as interindividual synchrony between members of the population, even at remote distances. This study addresses the question of how resetting of the ultradian rhythm, a prerequisite

  10. Reforming the Financial System Governing the Relationships Between Spouses (Marital Life, Common Properties

    Directory of Open Access Journals (Sweden)

    محمد روشن

    2017-03-01

    Full Text Available Separation of property is defined as a principle of matrimonial regime such as, «Alimony» (Nafaqe, «Seal» (Mahriyeh and «Quantum Meruit»  (Ojrat al-Mesl, in Iranian family law. Matrimonial regime in family law is- beside some other especial factors- mainly dependent on the "separation of property regime". But the result of this regime is not perfect. It seems that these factors are unable to create financial equality between spouses which is the main character of modern family law. In order to improve the financial structure of families and accommodate it with modern family requirements, we should redefine matrimonial regimes, for that to be able to create economic equality between spouses. There fore, it is recommended that the legislature, inspired by experiences of other legal systems, starts to modify the regime of separation and prepare the choice of “community of property” between spouses besides the currently existing financial regime.

  11. A Common Communications, Navigation and Surveillance Infrastructure for Accommodating Space Vehicles in the Next Generation Air Transportation System

    Science.gov (United States)

    VanSuetendael, RIchard; Hayes, Alan; Birr, Richard

    2008-01-01

    Suborbital space flight and space tourism are new potential markets that could significantly impact the National Airspace System (NAS). Numerous private companies are developing space flight capabilities to capture a piece of an emerging commercial space transportation market. These entrepreneurs share a common vision that sees commercial space flight as a profitable venture. Additionally, U.S. space exploration policy and national defense will impose significant additional demands on the NAS. Air traffic service providers must allow all users fair access to limited airspace, while ensuring that the highest levels of safety, security, and efficiency are maintained. The FAA's Next Generation Air Transportation System (NextGen) will need to accommodate spacecraft transitioning to and from space through the NAS. To accomplish this, space and air traffic operations will need to be seamlessly integrated under some common communications, navigation and surveillance (CNS) infrastructure. As part of NextGen, the FAA has been developing the Automatic Dependent Surveillance Broadcast (ADS-B) which utilizes the Global Positioning System (GPS) to track and separate aircraft. Another key component of NextGen, System-Wide Information Management/ Network Enabled Operations (SWIM/NEO), is an open architecture network that will provide NAS data to various customers, system tools and applications. NASA and DoD are currently developing a space-based range (SBR) concept that also utilizes GPS, communications satellites and other CNS assets. The future SBR will have very similar utility for space operations as ADS-B and SWIM has for air traffic. Perhaps the FAA, NASA, and DoD should consider developing a common space-based CNS infrastructure to support both aviation and space transportation operations. This paper suggests specific areas of research for developing a CNS infrastructure that can accommodate spacecraft and other new types of vehicles as an integrated part of NextGen.

  12. The breakthrough of common rail system. Closed-loop control strategy using injector with built-in pressure sensor

    Energy Technology Data Exchange (ETDEWEB)

    Miyaki, Masahiko; Takeuchi, Katsuhiko; Ishizuka, Koji; Sasaki, Satoru [DENSO Corporation, Aichi-ken (Japan)

    2009-07-01

    DENSO has developed the world's first common rail system injector with built-in pressure sensor. This technology makes it possible to execute closed loop injection control in the cylinders, which has been one of the most challenging issues for diesel engine systems. Attaining both further fuel economy and emission reduction requires further technological innovation in the air system and fuel injection system. With the combustion technology that has been developed, stable combustion with high exhaust gas recirculation (EGR) is required in order to reduce nitrogen oxide's (NOx), however robustness is also required in order to handle bio-diesel and low-cetane value fuels and the range for attaining this is extremely narrow. Therefore, for the fuel injection system, in addition to conventional high pressure and high response, lifetime accuracy compensation is key. With this newly developed technology, the fuel injection rate, which determines the combustion within the engine cylinders, is directly detected and controlled in a closed loop to allow precise compensation of the injection system for its entire service life. Highly advanced injection control allows for extremely close multiple injections and variable injection rate control to be possible on the mass production level for the first time. Furthermore, the use of this technology can provide three major advantages for the overall engine system. Firstly succeeds in an expansion of the possible calibration range, which improves fuel economy and emissions, secondly it provides an improvement in the overall engine robustness and reliability. Thirdly, the use of closed loop control makes it possible to greatly reduce the man-hours required for calibration. Given this, the new DENSO common rail system using injectors with built-in pressure sensors is the first step to opening up a new era of diesel engine control. (orig.)

  13. Occupational Burnout and Retention of Air Force Distributed Common Ground System (DCGS) Intelligence Personnel

    Science.gov (United States)

    2012-01-01

    Married ,” ( vs . unmarried ) and “Children at Home.” The survey also asked several work-related questions: AFSC, rank, years of military service...may actually ameliorate burnout. One study observed a consistent pattern of lower burnout for married individuals than for non- married , but far more...0 otherwise Young 1 if age is under 26, non-inclusive 0 otherwise Female 1 if female 0 otherwise Married 1 if married 0 otherwise Children at

  14. Extension of operational systems in computers of common use for application in systems for experimental equipment control

    International Nuclear Information System (INIS)

    Demidov, M.A.; Makarov, V.V.; Solov'ev, G.N.

    1985-01-01

    The problems of constructing specialized software for large complexes of experimental equipment and its functioning with serial operating systems (OS) are discussed. The main concepts being the base of dispatching software construction (an applied program package) extending the ES OS potentialities being used in the IHEP system for automatic data acquisition and accelerator control are considered

  15. The digital bee brain: integrating and managing neurons in a common 3D reference system

    Directory of Open Access Journals (Sweden)

    Jürgen Rybak

    2010-07-01

    Full Text Available The honeybee standard brain (HSB serves as an interactive tool for relating morphologies of bee brain neurons and provides a reference system for functional and bibliographical properties (http://www.neurobiologie.fu-berlin.de/beebrain/. The ultimate goal is to document not only the morphological network properties of neurons collected from separate brains, but also to establish a graphical user interface for a neuron-related data base. Here, we review the current methods and protocols used to incorporate neuronal reconstructions into the HSB. Our registration protocol consists of two separate steps applied to imaging data from two-channel confocal microscopy scans: (1 The reconstruction of the neuron, facilitated by an automatic extraction of the neuron’s skeleton based on threshold segmentation, and (2 the semi-automatic 3D segmentation of the neuropils and their registration with the HSB. The integration of neurons in the HSB is performed by applying the transformation computed in step (2 to the reconstructed neurons of step (1. The most critical issue of this protocol in terms of user interaction time – the segmentation process – is drastically improved by the use of a model-based segmentation process. Furthermore, the underlying statistical shape models (SSM allow the visualization and analysis of characteristic variations in large sets of bee brain data. The anatomy of neural networks composed of multiple neurons that are registered into the HSB are visualized by depicting the 3D reconstructions together with semantic information with the objective to integrate data from multiple sources (electrophysiology, imaging, immunocytochemistry, molecular biology. Ultimately, this will allow the user to specify cell types and retrieve their morphologies along with physiological characterizations.

  16. Common data elements collected among universities for sport-related concussion studies.

    Science.gov (United States)

    Yang, Jingzhen; Peek-Asa, Corinne; Noble, James M; Torner, James; Schmidt, Paul; Cooper, Martha L

    2018-02-12

    Universities are increasingly implementing programs to effectively respond to and manage sport-related concussions (SRCs). One such effort is to develop common data elements (CDEs) and standardize data collection methods. The objectives of this study were to describe CDEs currently collected by Big Ten and Ivy League universities for SRC studies, and to compare the data collected with the core CDEs recommended by the National Institute of Neurological Disorders and Stroke (NINDS). We conducted an anonymous cross-sectional online survey among medical staff at the 14 Big Ten and 8 Ivy League universities (one per university) between September and October 2015. The survey instrument, including 9 questions corresponding to the concussion data collected before, during, and after a concussion, was developed and pilot-tested before field use. We analyzed patterns of the concussion CDEs being collected, including when, what, and how the data were collected and stored, and compared them with the NINDS' recommended core CDEs. A total of 19 out of 22 universities were included, with 13 from Big Ten and 6 from Ivy-League universities. All 19 participating universities currently collected concussion data with athletes before, during, and after a concussion. Great similarities in data collection were observed at baseline and acutely post-concussion across participating universities. All 19 universities collected at least one of the ten recommended acute symptoms checklists, and 18 universities collected one of the four recommended core neuropsychological function cognitive measures. However, CDEs in the sub-acute and chronic timeframes were limited, with only 9 (47%) universities collecting post-concussion short to long term outcome data. While over 60% of universities collected and stored concussion data electronically, only 17% to 42% of data collected were readily available for research. Significant inter-institutional similarities in acute concussion CDEs were found. Further

  17. Association of common variants in mismatch repair genes and breast cancer susceptibility: a multigene study

    Directory of Open Access Journals (Sweden)

    Pina Julieta

    2009-09-01

    Full Text Available Abstract Background MMR is responsible for the repair of base-base mismatches and insertion/deletion loops. Besides this, MMR is also associated with an anti-recombination function, suppressing homologous recombination. Losses of heterozygosity and/or microsatellite instability have been detected in a large number of skin samples from breast cancer patients, suggesting a potential role of MMR in breast cancer susceptibility. Methods We carried out a hospital-based case-control study in a Caucasian Portuguese population (287 cases and 547 controls to estimate the susceptibility to non-familial breast cancer associated with some polymorphisms in mismatch repair genes (MSH3, MSH4, MSH6, MLH1, MLH3, PMS1 and MUTYH. Results Using unconditional logistic regression we found that MLH3 (L844P, G>A polymorphism GA (Leu/Pro and AA (Pro/Pro genotypes were associated with a decreased risk: OR = 0.65 (0.45-0.95 (p = 0.03 and OR = 0.62 (0.41-0.94 (p = 0.03, respectively. Analysis of two-way SNP interaction effects on breast cancer revealed two potential associations to breast cancer susceptibility: MSH3 Ala1045Thr/MSH6 Gly39Glu - AA/TC [OR = 0.43 (0.21-0.83, p = 0.01] associated with a decreased risk; and MSH4 Ala97Thr/MLH3 Leu844Pro - AG/AA [OR = 2.35 (1.23-4.49, p = 0.01], GG/AA [OR = 2.11 (1.12-3,98, p = 0.02], and GG/AG [adjusted OR = 1.88 (1.12-3.15, p = 0.02] all associated with an increased risk for breast cancer. Conclusion It is possible that some of these common variants in MMR genes contribute significantly to breast cancer susceptibility. However, further studies with a large sample size will be needed to support our results.

  18. Common prognostic factors of work disability among employees with a chronic somatic disease: a systematic review of cohort studies.

    NARCIS (Netherlands)

    Detaille, S.I.; Heerkens, Y.H.; Engels, J.A.; Gulden, J.W.J. van der; Dijk, F.J. van

    2009-01-01

    OBJECTIVE: Based on prospective and retrospective disease cohort studies, the aim of this review was to determine common prognostic factors for work disability among employees with rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, diabetes mellitus, and ischemic heart disease

  19. Common prognostic factors of work disability among employees with a chronic somatic disease: a systematic review of cohort studies

    NARCIS (Netherlands)

    Detaille, Sarah I.; Heerkens, Yvonne F.; Engels, Josephine A.; van der Gulden, Joost W. J.; van Dijk, Frank J. H.

    2009-01-01

    Objective Based on prospective and retrospective disease cohort studies, the aim of this review was to determine common prognostic factors for work disability among employees with rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, diabetes mellitus, and ischemic heart disease

  20. Parametric amplification and cascaded-nonlinearity processes in common atomic system.

    Science.gov (United States)

    Zheng, Huaibin; Zhang, Xun; Zhang, Zhaoyang; Tian, Yaling; Chen, Haixia; Li, Changbiao; Zhang, Yanpeng

    2013-01-01

    For the first time, we study the parametric amplification process of multi-wave mixing (PA-MWM) signal and cascaded-nonlinearity process (CNP) in sodium vapors both theoretically and experimentally, based on a conventional phase-conjugate MWM and a self-diffraction four-wave mixing (SD-FWM) processes, which are pumped by laser or amplified spontaneous emission (ASE), respectively. For laser pumping case, SD-FWM process serves as a quantum linear amplifier (a CNP) out (inside) of the resonant absorption region. While for ASE case, only the CNP occurs and the output linewidth is much narrower than that of the MWM signal due to the second selected effect of its electromagnetically induced transparency window. In addition, the phase-sensitive amplifying process seeded by two MWM processes is discussed for the first time. Theoretical fittings agree well with the experiment. The investigations have important potential applications in quantum communication.

  1. New York State Middle Schools and Instructional Scheduling, Teaming and Common Planning: A Descriptive Study

    Science.gov (United States)

    Corey, Chad; Babo, Gerard

    2016-01-01

    Data regarding the type of instructional scheduling utilized along with the use of teaming and common planning at the middle school level has not been collected nor reported on the New York State School Report Card, and therefore it is not known whether and how middle schools are implementing these three school supports. Consequently, the purpose…

  2. On Studying Common Factor Dominance and Approximate Unidimensionality in Multicomponent Measuring Instruments with Discrete Items

    Science.gov (United States)

    Raykov, Tenko; Marcoulides, George A.

    2018-01-01

    This article outlines a procedure for examining the degree to which a common factor may be dominating additional factors in a multicomponent measuring instrument consisting of binary items. The procedure rests on an application of the latent variable modeling methodology and accounts for the discrete nature of the manifest indicators. The method…

  3. The structure and stability of common mental disorders - The NEMESIS Study

    NARCIS (Netherlands)

    Vollebergh, W.A.M.; Iedema, J; Bijl, R.V.; de Graaf, R.; Smit, F.; Ormel, J.

    Background: We analyzed the underlying latent structure of 12-month DSM-III-R diagnoses of 9 common disorders for the general population in the Netherlands. In addition, we sought to establish (1) the stability of the latent structure underlying mental disorders across a 1-year period (structural

  4. Reviving common standards in point-count surveys for broad inference across studies

    Science.gov (United States)

    Steven M. Matsuoka; C. Lisa Mahon; Colleen M. Handel; Péter Sólymos; Erin M. Bayne; Patricia C. Fontaine; C. John Ralph

    2014-01-01

    We revisit the common standards recommended by Ralph et al. (1993, 1995a) for conducting point-count surveys to assess the relative abundance of landbirds breeding in North America. The standards originated from discussions among ornithologists in 1991 and were developed so that point-count survey data could be broadly compared and jointly analyzed by national data...

  5. The earthing system of the PRIMA Neutral Beam Test Facility based on the Mesh Common Bonding Network topology

    International Nuclear Information System (INIS)

    Pomaro, Nicola; Boldrin, Marco; Lazzaro, Gabriele

    2015-01-01

    Highlights: • We designed a high performance earthing system for the ITER Neutral Beam Test Facility. • The system is based on the Mesh Common Bonded Network topology. • Careful bonding of all metallic structures allowed to obtain a well meshed system. • Special care was dedicated to improve EMC performance of critical areas like control rooms. • The facility experimental results will be representative also of the ITER situation. - Abstract: PRIMA is a large experimental facility under realization in Padova, aimed at developing and testing the Neutral Beam Injectors for ITER. The operation of these devices involves high RF power and voltage up to 1 MV. Frequent and high voltage electrical breakdowns inside the beam sources occur regularly. The presence of a distributed carefully optimized earthing system is of paramount importance to achieve a satisfying disturbances immunity for equipment and diagnostics. The paper describes the design and the realization of the earthing system of the PRIMA facility, which is based on the MESH-Common Bonding Network (MESH-CBN) topology, as recommended by IEC and IEEE standards for installations with high levels of Electromagnetic Interferences (EMI). The principles of the MESH-CBN approach were adapted to the PRIMA layout, which is composed by several buildings, that are independent for seismic and architectural reasons, but are linked by many electrical conduits and hydraulic pipelines. The availability of huge foundations, with a large number of poles and pillars, was taken into account; building parts dedicated to host control rooms and sensitive equipment were treated with particular care. Moreover, the lightning protection system was integrated and harmonized with the earthing system.

  6. The earthing system of the PRIMA Neutral Beam Test Facility based on the Mesh Common Bonding Network topology

    Energy Technology Data Exchange (ETDEWEB)

    Pomaro, Nicola, E-mail: nicola.pomaro@igi.cnr.it; Boldrin, Marco; Lazzaro, Gabriele

    2015-10-15

    Highlights: • We designed a high performance earthing system for the ITER Neutral Beam Test Facility. • The system is based on the Mesh Common Bonded Network topology. • Careful bonding of all metallic structures allowed to obtain a well meshed system. • Special care was dedicated to improve EMC performance of critical areas like control rooms. • The facility experimental results will be representative also of the ITER situation. - Abstract: PRIMA is a large experimental facility under realization in Padova, aimed at developing and testing the Neutral Beam Injectors for ITER. The operation of these devices involves high RF power and voltage up to 1 MV. Frequent and high voltage electrical breakdowns inside the beam sources occur regularly. The presence of a distributed carefully optimized earthing system is of paramount importance to achieve a satisfying disturbances immunity for equipment and diagnostics. The paper describes the design and the realization of the earthing system of the PRIMA facility, which is based on the MESH-Common Bonding Network (MESH-CBN) topology, as recommended by IEC and IEEE standards for installations with high levels of Electromagnetic Interferences (EMI). The principles of the MESH-CBN approach were adapted to the PRIMA layout, which is composed by several buildings, that are independent for seismic and architectural reasons, but are linked by many electrical conduits and hydraulic pipelines. The availability of huge foundations, with a large number of poles and pillars, was taken into account; building parts dedicated to host control rooms and sensitive equipment were treated with particular care. Moreover, the lightning protection system was integrated and harmonized with the earthing system.

  7. Most common road safety engineering deficiencies in South Eastern Europe as a part of safe system approach

    Science.gov (United States)

    Jovanov, D.; Vollpracht, H. J.; Beles, H.; Popa, V.; Tolea, B. A.

    2017-10-01

    Most common road safety engineering deficiencies identified by the authors in South Eastern Europe, including Romania, have been collected together and presented in this paper as a part of road safety unbreakably connected to the safe system approach (driver-vehicle-road). In different South Eastern Europe countries Road Safety Audit (RSA), Road Safety Inspection (RSI), as well as Black Spot Management (BSM) was introduced and practical implementation experience enabled the authors to analyze the road safety problems. Typical road safety engineering deficiencies have been presented in 8 different subsections, based on PIARC (World Road Association) RSA approach. This paper presents collected common road safety problems with relevant illustrations (real pictures) with associated accident risks.

  8. Is the Relationship between Common Mental Disorder and Adiposity Bidirectional? Prospective Analyses of a UK General Population-Based Study.

    Science.gov (United States)

    Fezeu, Léopold K; Batty, G David; Batty, David G; Gale, Catharine R; Kivimaki, Mika; Hercberg, Serge; Czernichow, Sebastien

    2015-01-01

    The direction of the association between mental health and adiposity is poorly understood. Our objective was to empirically examine this link in a UK study. This is a prospective cohort study of 3 388 people (men) aged ≥ 18 years at study induction who participated in both the UK Health and Lifestyle Survey at baseline (HALS-1, 1984/1985) and the re-survey (HALS-2, 1991/1992). At both survey examinations, body mass index, waist circumference and self-reported common mental disorder (the 30-item General Health Questionnaire, GHQ) were measured. Logistic regression models were used to compute odds ratios (OR) and accompanying 95% confidence intervals (CI) for the associations between (1) baseline common mental disorder (QHQ score > 4) and subsequent general and abdominal obesity and (2) baseline general and abdominal obesity and re-survey common mental disorders. After controlling for a range of covariates, participants with common mental disorder at baseline experienced greater odds of subsequently becoming overweight (women, OR: 1.30, 1.03 - 1.64; men, 1.05, 0.81 - 1.38) and obese (women, 1.26, 0.82 - 1.94; men, OR: 2.10, 1.23 - 3.55) than those who were free of common mental disorder. Similarly, having baseline common mental health disorder was also related to a greater risk of developing moderate (1.57, 1.21 - 2.04) and severe (1.48, 1.09 - 2.01) abdominal obesity (women only). Baseline general or abdominal obesity was not associated with the risk of future common mental disorder. These findings of the present study suggest that the direction of association between common mental disorders and adiposity is from common mental disorder to increased future risk of adiposity as opposed to the converse.

  9. Applying the social-ecological system framework to the diagnosis of urban lake commons in Bangalore, India

    Directory of Open Access Journals (Sweden)

    Harini Nagendra

    2014-06-01

    Full Text Available The south Indian city of Bangalore provides a challenging yet representative context within which to examine issues of governance of urban social-ecological commons. The city was once famous for its numerous large water bodies, which have witnessed tremendous encroachment and pollution in recent years. These water bodies, called tanks or lakes, were typically managed by adjacent village communities but are now administered by a number of government departments involved with aspects of lake management, with multiple overlapping jurisdictions. The public's perceptions of lakes has also changed with urbanization, transitioning from community spaces valued for water and cultural services to urban recreational spaces used largely by joggers and walkers. We focus on a set of seven lakes located in the urbanizing peripheral areas of southeast Bangalore. Some water bodies have been restored and managed effectively by newly forged collaborations between citizens and local government. Others are extremely polluted, and some have completely dried up and have been encroached. We use a social-ecological system (SES framework to investigate why some locations have been successful in negotiating changes in governance from community-based systems to state management following urbanization, whereas other lakes have deteriorated. We use seven second-tier SES variables that were associated with self-organization in previous research: size of resource system, number of actors, leadership, social capital, importance of resource, existence of operational-choice rules, and existence of informal mechanisms for monitoring. We also include three third-tier variables previously identified as important in urban lake commons in Bangalore: scale and type of pre-existing pollution, exclusion of socioeconomic groups from the planning process, and networking with government organizations. We use this subset of 10 variables to examine social outcomes of the lakes, which we

  10. Software verification and validation methodology for advanced digital reactor protection system using diverse dual processors to prevent common mode failure

    International Nuclear Information System (INIS)

    Son, Ki Chang; Shin, Hyun Kook; Lee, Nam Hoon; Baek, Seung Min; Kim, Hang Bae

    2001-01-01

    The Advanced Digital Reactor Protection System (ADRPS) with diverse dual processors is being developed by the National Research Lab of KOPEC for ADRPS development. One of the ADRPS goals is to develop digital Plant Protection System (PPS) free of Common Mode Failure (CMF). To prevent CMF, the principle of diversity is applied to both hardware design and software design. For the hardware diversity, two different types of CPUs are used for Bistable Processor and Local Coincidence Logic Processor. The VME based Single Board Computers (SBC) are used for the CPU hardware platforms. The QNX Operating System (OS) and the VxWorks OS are used for software diversity. Rigorous Software Verification and Validation (V and V) is also required to prevent CMF. In this paper, software V and V methodology for the ADRPS is described to enhance the ADRPS software reliability and to assure high quality of the ADRPS software

  11. Study on HVAC system in nuclear facility

    International Nuclear Information System (INIS)

    Baeg, S. Y.; Song, W. S.; Oh, Y. O.; Ju, Y. S.; Hong, K. P.

    2003-01-01

    Heating, Ventilation and Air Conditioning (HVAC) system in nuclear facility should be equipped and constructed more stable and allowable than that in common facility. The purpose of HVAC system is the maintenance of optimum working environment, the protection of worker against a contaminated air and the prevention of atmospheric contamination due to an outward ventilation, etc.. The basic scheme of a safety operation of nuclear facility is to prevent the atmospheric contamination even in low level. The adaptability of HVAC system which is in operation. In this study, the design requirements of HVAC system in nuclear facility and the HVAC systems in foreign countries are reviewed, and the results can be utilized in the design of HVAC system in nuclear facility

  12. Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design.

    Science.gov (United States)

    Castaño-Vinyals, Gemma; Aragonés, Nuria; Pérez-Gómez, Beatriz; Martín, Vicente; Llorca, Javier; Moreno, Victor; Altzibar, Jone M; Ardanaz, Eva; de Sanjosé, Sílvia; Jiménez-Moleón, José Juan; Tardón, Adonina; Alguacil, Juan; Peiró, Rosana; Marcos-Gragera, Rafael; Navarro, Carmen; Pollán, Marina; Kogevinas, Manolis

    2015-01-01

    We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain. Copyright © 2014 SESPAS. Published by Elsevier Espana. All rights reserved.

  13. Developing common information elements for renewable energy systems: summary and proceedings of the SERI/AID workshop

    Energy Technology Data Exchange (ETDEWEB)

    Ashworth, J.H.; Neuendorffer, J.W.

    1980-06-01

    This report describes the activities, conclusions, and recommendations of the Workshop on Evaluation Systems for Renewable Energy Systems sponsored by the Agency for International Development and SERI, held 20-22 February 1980 in Golden, Colorado. The primary objectives of the workshop was to explore whether it was possible to establish common information elements that would describe the operation and impact of renewable energy projects in developing countries. The workshop provided a forum for development program managers to discuss the information they would like to receive about renewable energy projects and to determine whether common data could be agreed on to facilitate information exchange among development organizations. Such information could be shared among institutions and used to make informed judyments on the economic, technical, and social feasibility of the technologies. Because developing countries and foreign assistance agencies will be financing an increasing number of renewable energy projects, these organizations need information on the field experience of renewable energy technologies. The report describes the substance of the workshop discussions and includes the papers presented on information systems and technology evaluation and provides lists of important information elements generated by both the plenary sessions and the small working groups.

  14. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities - A General Overview

    Science.gov (United States)

    Hebert, Phillip W., Sr.; Hughes, Mark S.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Marshall, PeggL.; Duncan, Michael E.; Morris, Jon A.; Franzl, Richard W.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition system (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis' development and deployment.

  15. Is There a Common Summary Statistical Process for Representing the Mean and Variance? A Study Using Illustrations of Familiar Items.

    Science.gov (United States)

    Yang, Yi; Tokita, Midori; Ishiguchi, Akira

    2018-01-01

    A number of studies revealed that our visual system can extract different types of summary statistics, such as the mean and variance, from sets of items. Although the extraction of such summary statistics has been studied well in isolation, the relationship between these statistics remains unclear. In this study, we explored this issue using an individual differences approach. Observers viewed illustrations of strawberries and lollypops varying in size or orientation and performed four tasks in a within-subject design, namely mean and variance discrimination tasks with size and orientation domains. We found that the performances in the mean and variance discrimination tasks were not correlated with each other and demonstrated that extractions of the mean and variance are mediated by different representation mechanisms. In addition, we tested the relationship between performances in size and orientation domains for each summary statistic (i.e. mean and variance) and examined whether each summary statistic has distinct processes across perceptual domains. The results illustrated that statistical summary representations of size and orientation may share a common mechanism for representing the mean and possibly for representing variance. Introspections for each observer performing the tasks were also examined and discussed.

  16. Common mechanisms of spatial attention in memory and perception: a tactile dual-task study.

    Science.gov (United States)

    Katus, Tobias; Andersen, Søren K; Müller, Matthias M

    2014-03-01

    Orienting attention to locations in mnemonic representations engages processes that functionally and anatomically overlap the neural circuitry guiding prospective shifts of spatial attention. The attention-based rehearsal account predicts that the requirement to withdraw attention from a memorized location impairs memory accuracy. In a dual-task study, we simultaneously presented retro-cues and pre-cues to guide spatial attention in short-term memory (STM) and perception, respectively. The spatial direction of each cue was independent of the other. The locations indicated by the combined cues could be compatible (same hand) or incompatible (opposite hands). Incompatible directional cues decreased lateralized activity in brain potentials evoked by visual cues, indicating interference in the generation of prospective attention shifts. The detection of external stimuli at the prospectively cued location was impaired when the memorized location was part of the perceptually ignored hand. The disruption of attention-based rehearsal by means of incompatible pre-cues reduced memory accuracy and affected encoding of tactile test stimuli at the retrospectively cued hand. These findings highlight the functional significance of spatial attention for spatial STM. The bidirectional interactions between both tasks demonstrate that spatial attention is a shared neural resource of a capacity-limited system that regulates information processing in internal and external stimulus representations.

  17. A Pilot Study of Common Bile Duct Reconstruction with CorMatrix Extracellular Matrix in Swine (Sus scrofa)

    Science.gov (United States)

    2015-02-06

    additional pages if necessary.) PROTOCOL#: FDG20140008A DATE: 6 February 2015 PROTOCOL TITLE: A Pilot Study of Common Bile Duct Reconstruction with...obstruction or bile peritonitis. This was reported to the IACUC chair. 9. REDUCTION, REFINEMENT, OR REPLACEMENT OF ANIMAL USE; REPLACEMENT...benefit the DoD/USAF? We developed a porcine model of common bile duct injury and interposition grafting, gained experience managing these patients

  18. Fusion reactor systems studies

    International Nuclear Information System (INIS)

    1993-01-01

    Fusion Technology Institute personnel actively participated in the ARIES/PULSAR project during the present contract period. Numerous presentations were made at PULSAR project meetings, major contributions were written for the ARIES-II/IV Final Report presentations and papers were given at technical conferences contributions were written for the ARIES Lessons Learned report and a very large number of electronic-mail and regular-mail communications were sent. The remaining sections of this progress report win summarize the work accomplished and in progress for the PULSAR project during the contract period. The main areas of effort are: PULSAR Research; ARIES-II/IV Report Contributions; ARIES Lessons Learned Report Contributions; and Stellarator Study

  19. Bioaccessibility and bioavailability of methylmercury from seafood commonly consumed in North America: In vitro and epidemiological studies.

    Science.gov (United States)

    Siedlikowski, Maia; Bradley, Mark; Kubow, Stan; Goodrich, Jaclyn M; Franzblau, Alfred; Basu, Niladri

    2016-08-01

    Methylmercury (MeHg) is a global contaminant of concern and human exposures are largely realized via seafood consumption. While it is assumed that 95-100% of the ingested MeHg from seafood reaches systemic circulation, recent in vitro studies have yielded results to suggest otherwise. Of the published studies to have characterized the bioaccessibility or bioavailability of MeHg from seafood, only a handful of seafood species have been characterized, there exists tremendous variability in data within and across species, few species of relevance to North America have been studied, and none of the in vitro studies have adapted results to an epidemiology study. The objective of the current study was two-fold: (a) to characterize in vitro MeHg bioaccessibility and bioavailability from ten commonly consumed types of seafood in North America; and (b) to apply the bioaccessibility and bioavailability data from the in vitro study to an existing human MeHg exposure assessment study. Raw seafood samples (cod, crab, halibut, salmon, scallop, shrimp, tilapia, and three tuna types: canned light, canned white, fresh) were purchased in Montreal and their MeHg concentrations generally overlapped with values reported elsewhere. The bioaccessibility of MeHg from these samples ranged from 50.1±19.2 (canned white tuna) to 100% (shrimp and scallop) of the amount measured in the raw undigested sample. The bioavailability of MeHg from these samples ranged from 29.3±10.4 (crab) to 67.4±9.7% (salmon) of the value measured in the raw undigested sample. There were significant correlations between the initial MeHg concentration in seafood with the percent of that Hg that was bioaccessible (r=-0.476) and bioavailable (r=-0.294). When the in vitro data were applied to an existing MeHg exposure assessment study, the estimated amount of MeHg absorbed into systemic circulation decreased by 25% and 42% when considering bioaccessibility and bioavailability, respectively. When the in vitro data

  20. [Vulnerability of women in common-law marriage to becoming infected with HIV/AIDS: a study of social representations].

    Science.gov (United States)

    Rodrigues, Larissa Silva Abreu; Paiva, Mirian Santos; de Oliveira, Jeane Freitas; da Nóbrega, Sheva Maia

    2012-04-01

    This article discusses the social representations of women living in common-law marriage in terms of their vulnerability to becoming infected with HIV/AIDS. Data were obtained through the free association of words, and consisted of an excerpt of a study founded on the Social Representations Theory developed with HIV-negative women living in the state capital and cities in the interior of Bahia. The correspondence factor analysis showed significance for the variables: origin, education level and time spent in common-law marriage. Their acceptance of marital affairs emerged as a vulnerability factor for respondents with one to five years spent in common-law marriage, living in cities in the interior. Women from the capital, with 6-10 years spent in common-law marriage, reported monogamy as a form of prevention. Women with a longer common-law marriage who had completed only a primary education reported feeling invulnerable, which was the opposite of those with one to five years in common-law marriage with a secondary education. Results show there is a need for more interventions aiming to denaturalize the socio-cultural coercions that generate representations and make women in common-law marriages more vulnerable to AIDS.

  1. Europe Agrees on Common Strategy to Initiate Study of LSA/MMA

    Science.gov (United States)

    1998-09-01

    Council Specifies ESO's Role in Planning In an extraordinary meeting at the ESO Headquarters, the ESO Council today endorsed ESO's involvement in the planning of a major new astronomical facility in the southern hemisphere. Some years from now, the Large Southern Array/Millimetre Array (LSA/MMA) may become the world's prime sub-mm/mm radio observatory [1] at a pristine site at 5000 m altitude in the Chilean Andes, not very far from the VLT Paranal Observatory. Background One of the highest-priority items in astronomy today is a large millimetre-wavelength array. This would be a millimetre counterpart to the ESO VLT and the NASA/ESA Hubble Space Telescope (HST), with similar scientific objectives and comparable high angular resolution and sensitivity. An antenna array with about 10,000 m 2 area would provide very high sensitivity and angular resolution, compatible with that of the VLT and HST. Such a large collecting area implies an array with many antennas and baselines, which give the added advantage of fast, high-quality images. The site must be high, dry, large, and flat - a high plateau in the Atacama desert is ideal, and has the great advantage of being in the southern hemisphere, important for compatibility with the VLT. Thus, discussions in Europe have focussed on a "Large Southern Array" (LSA) . The scientific case for such a telescope is overwhelming. It would be able to study the origins of galaxies and stars: the epoch of first galaxy formation and the evolution of galaxies at later stages, including the dust-obscured star-forming galaxies that the HST and VLT cannot see, and all phases of star formation hidden away in dusty molecular clouds. But the LSA will go far beyond these main science drivers - it will have a major impact on virtually all areas of astronomy, and make millimetre astronomy accessible to all astronomers. It may well have as big a user community as the VLT itself. European involvement in millimetre astronomy Europe already has a

  2. A study on the assessment of safety culture impacts on risk of nuclear power plants using common uncertainty source model

    International Nuclear Information System (INIS)

    Lee, Yong Suk; Bang, Young Suk; Chung, Chang Hyun; Jeong, Ji Hwan

    2004-01-01

    Since International Safety Advisory Group (INSAG) introduced term 'safety culture', it has been widely recognized that safety culture has an important role in safety of nuclear power plants. Research on the safety culture can be divided in the following two parts. 1) Assessment of safety culture (by interview, questionnaire, etc.) 2) Assessment of link between safety culture and safety of nuclear power plants. There is a substantial body of literature that addresses the first part, but there is much less work that addresses the second part. To address the second part, most work focused on the development of model incorporating safety culture into Probabilistic Safety Assessment (PSA). One of the most advanced methodology in the area of incorporating safety culture quantitatively into PSA is System Dynamics (SD) model developed by Kwak et al. It can show interactions among various factors which affect employees' productivity and job quality. Also various situations in nuclear power plant can be simulated and time-dependent risk can be recalculated with this model. But this model does not consider minimal cut set (MCS) dependency and uncertainty of risk. Another well-known methodology is Work Process Analysis Model (WPAM) developed by Davoudian. It considers MCS dependency by modifying conditional probability values using SLI methodology. But we found that the modified conditional probability values in WPAM are somewhat artificial and have no sound basis. WPAM tend to overestimate conditional probability of hardware failure, because it uses SLI methodology which is normally used in Human Reliability Analysis (HRA). WPAM also does not consider uncertainty of risk. In this study, we proposed methodology to incorporate safety culture into PSA quantitatively that can deal with MCS dependency and uncertainty of risk by applying the Common Uncertainty Source (CUS) model developed by Zhang. CUS is uncertainty source that is common to basic events, and this can be physical

  3. Hydrogen energy systems studies

    Energy Technology Data Exchange (ETDEWEB)

    Ogden, J.M.; Kreutz, T.G.; Steinbugler, M. [Princeton Univ., NJ (United States)] [and others

    1996-10-01

    In this report the authors describe results from technical and economic assessments carried out during the past year with support from the USDOE Hydrogen R&D Program. (1) Assessment of technologies for small scale production of hydrogen from natural gas. Because of the cost and logistics of transporting and storing hydrogen, it may be preferable to produce hydrogen at the point of use from more readily available energy carriers such as natural gas or electricity. In this task the authors assess near term technologies for producing hydrogen from natural gas at small scale including steam reforming, partial oxidation and autothermal reforming. (2) Case study of developing a hydrogen vehicle refueling infrastructure in Southern California. Many analysts suggest that the first widespread use of hydrogen energy is likely to be in zero emission vehicles in Southern California. Several hundred thousand zero emission automobiles are projected for the Los Angeles Basin alone by 2010, if mandated levels are implemented. Assuming that hydrogen vehicles capture a significant fraction of this market, a large demand for hydrogen fuel could evolve over the next few decades. Refueling a large number of hydrogen vehicles poses significant challenges. In this task the authors assess near term options for producing and delivering gaseous hydrogen transportation fuel to users in Southern California including: (1) hydrogen produced from natural gas in a large, centralized steam reforming plant, and delivered to refueling stations via liquid hydrogen truck or small scale hydrogen gas pipeline, (2) hydrogen produced at the refueling station via small scale steam reforming of natural gas, (3) hydrogen produced via small scale electrolysis at the refueling station, and (4) hydrogen from low cost chemical industry sources (e.g. excess capacity in refineries which have recently upgraded their hydrogen production capacity, etc.).

  4. Ultrasonographic study of common carotid arteries in adolescents with type 1 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Viktoriya Nikolaevna Panfilova

    2009-03-01

    Full Text Available Aim. To elucidate sonographic characteristics of common carotid arteries in adolescents with type1 diabetes mellitus (DM1 depending on the duration of the disease and thepresence of chronic complications. Materials and methods. A total of 56 adolescents having DM1 of different duration were examined to evaluate conditions of common carotid arteries (CA in the systole anddiastole during at least 3 cardiac cycles. The following parameters were measured: CA diameter, intima-media thickness (IMT, estimated stretch and stiffness coefficients, Youngsmodulus. The control group comprised 16 healthy adolescents. Results. Bilateral increase of IMT was recorded in patients with DM duration over 5 years. Youngs modulus, stretch and stiffness coefficients were virtually unrelated to diseaseduration. In patients having DM for more than 10 years, stretch coefficient was 5.38 (95% DI 4.82-5.8 compared with 5.82 (95% DI 5.63-7.38 in those with DM for less than 3years (p = 0.04. The level of albuminuria correlated with IMT (r=0.32, p=0.03, stiffness coefficient (r = 0.43, p=0.001, stretch coefficient (r= -0.48, p

  5. Study on the seed production and germination dynamic of common milkweed (Asclepias syriaca L.).

    Science.gov (United States)

    Sárkány, S E; Lehoczky, E; Nagy, P

    2008-01-01

    The common milkweed causes considerable damages on the agricultural and nature conservation areas. The area occupied by this weed is continuously bigger. The common milkweed is spread over North-America between the 35th and 50th degree of western Latitude and 60th 103rd degree of longitude. Millions of hectares are polluted by this weed in the United States. Important is its spread also in Asia (Iraq), in Europe (Carpathian Basin, Poland, Bulgaria, Switzerland, France, Austria, Germany), as well as in the area of the former Soviet Union (Belorussia, The Baltic Countries, Caucasus, and the Ukraine). Though the basic biological characters of this plant are well known, still its control is a significant problem, the damages increase on the areas occupied by this weed. We collect seed samples from several Hungarian areas in 2007. After the sampling we determined the average sprout length and the number of follicle as well as the average seed numbers in the follicle. We determined also the weight of thousand seeds of the resultant seed samples. At natural circumstances the seedlings appear at a soil temperature of 15 degrees C during the end of April and first week of May. Under Laboratory circumstances the dormancy of the seeds ceases continuously from November on, germinate at a temperature of 20-30 degrees C, the maximum germination can be achieved in the first part of April. At January we started germination examinations with the seeds in Petri dish, among laboratory condition.

  6. Cognitive behaviour therapy for common mental disorders in people with Multiple Sclerosis: A bench marking study.

    Science.gov (United States)

    Askey-Jones, S; David, A S; Silber, E; Shaw, P; Chalder, T

    2013-10-01

    Mental health problems such as depression and anxiety are common in Multiple Sclerosis (MS) and are often under treated. This paper reports on the clinical effectiveness of a cognitive behaviour therapy service for common mental disorders in people with MS and compares it to previous randomised controlled trials (RCTs) of cognitive behaviour therapy (CBT) in this population. 49 patients were deemed appropriate for CBT and 29 accepted treatment. Assessments were completed at baseline and end of treatment and included the Hospital Anxiety & Depression Scale. Results in the form of a standardized effect of treatment were compared with five previous RCTs. The results from this clinical service indicated statistically significant outcomes with reductions in depression and anxiety. The uncontrolled effect size was large but inferior to those found in published RCTs. Cognitive behaviour therapy is effective for people with MS in routine clinical practice. Possible limits on effectiveness include more liberal patient selection, lack of specificity in rating scales and heterogeneity of target problems. Given the high rates of distress in this population, routine psychological interventions within neurology services are justifiable. Future research should aim to maximise CBT in such settings. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. PRIMARY MULTIPLE MALIGNAT TUMORS MOST COMMON LOCALIZATIONS CANCER - CANCER STUDY CLINICS

    Directory of Open Access Journals (Sweden)

    G. V. Goncharenko

    2015-01-01

    Full Text Available The purpose. Analysis of statistical data of oncological departmental polyclinics, serving a permanent attached contingent of patients in cases of the most common cancer sites: basal cell skin cancer, breast cancer, prostate cancer. Materials and methods. Analisis of medical history patients of polyclinics. There were registered 1054 patients with malignant tumors. Of these 128 (12.14% and had the PMN, of that number, 8 patients had triple the localization of cancer. BCC: skin diagnosis was 132 patients, of which 52 (39.9% of had the PMN. With the diagnosis: breast cancer was registered 179 patients, including 30 patients had the PMN of the 8 patients had bilateral breast cancer. Diagnosed with FPW to outpatients included 139 patients, of whom 20 people (14.4%. On each localization of cancer presented with second and third cancer localizations. Conclusion. Patients with BCC skin were the in group of high risk for the development of PMN. The second location was in case of every third patient. Most commonly BCC combined with breast cancer, prostate cancer, cancer of the colon.

  8. Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b

    Directory of Open Access Journals (Sweden)

    Lee Robert E

    2006-01-01

    Full Text Available Abstract Background There have been indications that common Angiotensin Receptor Blockers (ARBs may be exerting anti-inflammatory actions by directly modulating the immune system. We decided to use molecular modelling to rapidly assess which of the potential targets might justify the expense of detailed laboratory validation. We first studied the VDR nuclear receptor, which is activated by the secosteroid hormone 1,25-dihydroxyvitamin-D. This receptor mediates the expression of regulators as ubiquitous as GnRH (Gonadatrophin hormone releasing hormone and the Parathyroid Hormone (PTH. Additionally we examined Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma, which affects the function of phagocytic cells, and the C-CChemokine Receptor, type 2b, (CCR2b, which recruits monocytes to the site of inflammatory immune challenge. Results Telmisartan was predicted to strongly antagonize (Ki≈0.04nmol the VDR. The ARBs Olmesartan, Irbesartan and Valsartan (Ki≈10 nmol are likely to be useful VDR antagonists at typical in-vivo concentrations. Candesartan (Ki≈30 nmol and Losartan (Ki≈70 nmol may also usefully inhibit the VDR. Telmisartan is a strong modulator of PPARgamma (Ki≈0.3 nmol, while Losartan (Ki≈3 nmol, Irbesartan (Ki≈6 nmol, Olmesartan and Valsartan (Ki≈12 nmol also seem likely to have significant PPAR modulatory activity. Olmesartan andIrbesartan (Ki≈9 nmol additionally act as antagonists of a theoretical modelof CCR2b. Initial validation of this CCR2b model was performed, and a proposed model for the AngiotensinII Type1 receptor (AT2R1 has been presented. Conclusion Molecular modeling has proven valuable to generate testable hypotheses concerning receptor/ligand binding and is an important tool in drug design. ARBs were designed to act as antagonists for AT2R1, and it was not surprising to discover their affinity for the structurally similar CCR2b. However, this study also found evidence that ARBs modulate the

  9. Enhanced integrated nonthermal treatment system study

    International Nuclear Information System (INIS)

    Biagi, C.; Schwinkendorf, B.; Teheranian, B.

    1997-02-01

    The purpose of the Enhanced Nonthermal Treatment Systems (ENTS) study is to evaluate alternative configurations of one of the five systems evaluated in the Integrated Nonthermal Treatment Systems (INTS) study. Five alternative configurations are evaluated. Each is designed to enhance the final waste form performance by replacing grout with improved stabilization technologies, or to improve system performance by improving the destruction efficiency for organic contaminants. AU enhanced systems are alternative configurations of System NT-5, which has the following characteristics: Nonthermal System NT-5: (1) catalytic wet oxidation (CWO) to treat organic material including organic liquids, sludges, and soft (or combustible) debris, (2) thermal desorption of inorganic sludge and process residue, (3) washing of soil and inorganic debris with treatment by CWO of removed organic material, (4) metal decontamination by abrasive blasting, (5) stabilization of treated sludge, soil, debris, and untreated debris with entrained contamination in grout, and (6) stabilization of inorganic sludge, salts and secondary waste in polymer. System NT-5 was chosen because it was designed to treat combustible debris thereby minimizing the final waste form volume, and because it uses grout for primary stabilization. The enhanced nonthermal systems were studied to determine the cost and performance impact of replacing grout (a commonly used stabilization agent in the DOE complex) with improved waste stabilization methods such as vitrification and polymer

  10. Mars power system concept definition study. Volume 1: Study results

    Science.gov (United States)

    Littman, Franklin D.

    1994-01-01

    A preliminary top level study was completed to define power system concepts applicable to Mars surface applications. This effort included definition of power system requirements and selection of power systems with the potential for high commonality. These power systems included dynamic isotope, Proton Exchange Membrane (PEM) regenerative fuel cell, sodium sulfur battery, photovoltaic, and reactor concepts. Design influencing factors were identified. Characterization studies were then done for each concept to determine system performance, size/volume, and mass. Operations studies were done to determine emplacement/deployment maintenance/servicing, and startup/shutdown requirements. Technology development roadmaps were written for each candidate power system (included in Volume 2). Example power system architectures were defined and compared on a mass basis. The dynamic isotope power system and nuclear reactor power system architectures had significantly lower total masses than the photovoltaic system architectures. Integrated development and deployment time phasing plans were completed for an example DIPS and reactor architecture option to determine the development strategies required to meet the mission scenario requirements.

  11. Ophthalmic effects of petroleum dispersant exposure on common murres (Uria aalge): An experimental study.

    Science.gov (United States)

    Fiorello, Christine V; Freeman, Kate; Elias, Becky A; Whitmer, Emily; Ziccardi, Michael H

    2016-12-15

    The safety of chemical dispersants used during oil spill responses is largely unknown in birds. We captured common murres in Monterey Bay, CA and exposed them to Corexit EC9500a, crude oil, or a combination in artificial seawater. We performed ophthalmic examinations and measured intraocular pressures and tear production before and after exposure. Loglinear analysis found that exposure to oil or dispersant was related to the development of conjunctivitis and corneal ulcers. Odds ratios for birds exposed to oil or dispersant were positive and significant for the development of conjunctivitis, while odds ratios for the development of corneal ulcers were positive and significant only for birds exposed to a high concentration of oil. Ocular exposure to dispersants and petroleum in seabirds may cause conjunctivitis and may play a role in the development of corneal ulcers. These results have implications for policymakers who develop protocols for the use of dispersants during marine oil spills. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Comprehensive study of unexpected microscope condensers formed in sample arrangements commonly used in optical microscopy.

    Science.gov (United States)

    Desai, Darshan B; Aldawsari, Mabkhoot Mudith S; Alharbi, Bandar Mohammed H; Sen, Sanchari; Grave de Peralta, Luis

    2015-09-01

    We show that various setups for optical microscopy which are commonly used in biomedical laboratories behave like efficient microscope condensers that are responsible for observed subwavelength resolution. We present a series of experiments and simulations that reveal how inclined illumination from such unexpected condensers occurs when the sample is perpendicularly illuminated by a microscope's built-in white-light source. In addition, we demonstrate an inexpensive add-on optical module that serves as an efficient and lightweight microscope condenser. Using such add-on optical module in combination with a low-numerical-aperture objective lens and Fourier plane imaging microscopy technique, we demonstrate detection of photonic crystals with a period nearly eight times smaller than the Rayleigh resolution limit.

  13. A Photodegradation Study of Three Common Paint and Plaster Biocides under monochromatic UV Light

    DEFF Research Database (Denmark)

    Minelgaite, Greta; Vollertsen, Jes; Nielsen, Asbjørn Haaning

    2014-01-01

    Photodegradation of the three common paint-and-plaster biocides (carbendazim, diuron and terbutryn) was investigated at controlled laboratory conditions. Samples prepared in two types of water (demineralized water and pond water) were subjected to 254 nm monochromatic UV light. Light intensity (W m......-2) in the experimental chamber was measured by a fiber optic spectrometer. The observed decline in biocide concentration was related with the light energy, accumulated during the time of degradation (kJ m-2), and 1st order photodegradation rate constants (m2 kJ-1) were determined. The obtained...... at selected laboratory conditions, as well as emphasize the importance of water type when investigating pollutant’s photo fate, as certain constituents might act as reaction enhancers or inhibitors....

  14. Titrating the Cost of Plant Toxins Against Predators: a Case Study with Common Duikers, Sylvicapra grimmia.

    Science.gov (United States)

    Abu Baker, Mohammad A

    2015-10-01

    Foragers face many variables that influence their food intake. These may include habitat structure, time, climate, resource characteristic, food quality, and plant defenses. I conducted foraging experiments using common duikers that involved: 1) testing the effect of plant toxins on foraging, and 2) titrating toxin intake against safety. I used giving up densities (GUDs, food remaining after foraging) to test for selection among trays containing alfalfa pellets treated with water, with 10% oxalic acid, or 10% quebracho tannin. Pairs of trays were placed within islands of woody vegetation and out in open grass. I also conducted a titration experiment by offering the duikers a choice between a patch with water-treated pellets placed at a risky site, or a patch with one of three oxalic acid-treated pellets at a safe site. This made it possible to determine the concentration of oxalic acid at which the cost of toxin in the safe site equals the predation cost at the risky site. The common duikers showed no selectivity among the three treatments at 10% concentration, however, GUDs in the open grass (i.e., safe) were significantly lower than in the wooded islands (i.e., risky). As the oxalic acid concentration increased at the safe sites, the duiker's food intake from the risky sites increased significantly. The results demonstrate that foraging hazards may come in different forms such as predation and plant toxins, and their interactions may alter habitat use, foraging patterns, and perceptions of risk. These variables occur under natural situations, altering the overall habitat quality.

  15. Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

    Science.gov (United States)

    Pellegrini, Carolina; Antonioli, Luca; Colucci, Rocchina; Blandizzi, Corrado; Fornai, Matteo

    2018-05-24

    Neurological diseases, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS) and multiple sclerosis, are often associated with functional gastrointestinal disorders. These gastrointestinal disturbances may occur at all stages of the neurodegenerative diseases, to such an extent that they are now considered an integral part of their clinical picture. Several lines of evidence support the contention that, in central neurodegenerative diseases, changes in gut microbiota and enteric neuro-immune system alterations could contribute to gastrointesinal dysfunctions as well as initiation and upward spreading of the neurologic disorder. The present review has been intended to provide a comprehensive overview of the available knowledge on the role played by enteric microbiota, mucosal immune system and enteric nervous system, considered as an integrated network, in the pathophysiology of the main neurological diseases known to be associated with intestinal disturbances. In addition, based on current human and pre-clinical evidence, our intent was to critically discuss whether changes in the dynamic interplay between gut microbiota, intestinal epithelial barrier and enteric neuro-immune system are a consequence of the central neurodegeneration or might represent the starting point of the neurodegenerative process. Special attention has been paid also to discuss whether alterations of the enteric bacterial-neuro-immune network could represent a common path driving the onset of the main neurodegenerative diseases, even though each disease displays its own distinct clinical features.

  16. Developing a common strategy for integrative global change research and outreach: the Earth System Science Partnership (ESSP)

    NARCIS (Netherlands)

    Leemans, R.; Asrar, G.; Canadell, J.G.; Ingram, J.; Larigauderie, A.; Mooney, H.; Nobre, C.; Patwardhan, A.; Rice, M.; Schmidt, F.; Seitzinger, S.; Virji, H.; Vörösmarthy, C.; Yuoung, O.

    2009-01-01

    The Earth System Science Partnership (ESSP) was established in 2001 by four global environmental change (GEC) research programmes: DIVERSITAS, IGBP, IHDP and WCRP. ESSP facilitates the study of the Earth's environment as an integrated system in order to understand how and why it is changing, and to

  17. The effects of common footwear on stance-phase mechanical properties of the prosthetic foot-shoe system.

    Science.gov (United States)

    Major, Matthew J; Scham, Joel; Orendurff, Michael

    2018-04-01

    Prosthetic feet are prescribed based on their mechanical function and user functional level. Subtle changes to the stiffness and hysteresis of heel, midfoot, and forefoot regions can influence the dynamics and economy of gait in prosthesis users. However, the user's choice of shoes may alter the prosthetic foot-shoe system mechanical characteristics, compromising carefully prescribed and rigorously engineered performance of feet. Observe the effects of footwear on the mechanical properties of the prosthetic foot-shoe system including commonly prescribed prosthetic feet. Repeated-measures, Mechanical characterization. The stiffness and energy return was measured using a hydraulic-driven materials test machine across combinations of five prosthetic feet and four common shoes as well as a barefoot condition. Heel energy return decreased by an average 4%-9% across feet in all shoes compared to barefoot, with a cushioned trainer displaying the greatest effect. Foot designs that may improve perceived stability by providing low heel stiffness and rapid foot-flat were compromised by the addition of shoes. Shoes altered prosthesis mechanical characteristics in the sagittal and frontal planes, suggesting that shoe type should be controlled or reported in research comparing prostheses. Understanding of how different shoes could alter certain gait-related characteristics of prostheses may aid decisions on footwear made by clinicians and prosthesis users. Clinical relevance Shoes can alter function of the prosthetic foot-shoe system in unexpected and sometimes undesirable ways, often causing similar behavior across setups despite differences in foot design, and prescribing clinicians should carefully consider these effects on prosthesis performance.

  18. Multispectral imaging burn wound tissue classification system: a comparison of test accuracies between several common machine learning algorithms

    Science.gov (United States)

    Squiers, John J.; Li, Weizhi; King, Darlene R.; Mo, Weirong; Zhang, Xu; Lu, Yang; Sellke, Eric W.; Fan, Wensheng; DiMaio, J. Michael; Thatcher, Jeffrey E.

    2016-03-01

    The clinical judgment of expert burn surgeons is currently the standard on which diagnostic and therapeutic decisionmaking regarding burn injuries is based. Multispectral imaging (MSI) has the potential to increase the accuracy of burn depth assessment and the intraoperative identification of viable wound bed during surgical debridement of burn injuries. A highly accurate classification model must be developed using machine-learning techniques in order to translate MSI data into clinically-relevant information. An animal burn model was developed to build an MSI training database and to study the burn tissue classification ability of several models trained via common machine-learning algorithms. The algorithms tested, from least to most complex, were: K-nearest neighbors (KNN), decision tree (DT), linear discriminant analysis (LDA), weighted linear discriminant analysis (W-LDA), quadratic discriminant analysis (QDA), ensemble linear discriminant analysis (EN-LDA), ensemble K-nearest neighbors (EN-KNN), and ensemble decision tree (EN-DT). After the ground-truth database of six tissue types (healthy skin, wound bed, blood, hyperemia, partial injury, full injury) was generated by histopathological analysis, we used 10-fold cross validation to compare the algorithms' performances based on their accuracies in classifying data against the ground truth, and each algorithm was tested 100 times. The mean test accuracy of the algorithms were KNN 68.3%, DT 61.5%, LDA 70.5%, W-LDA 68.1%, QDA 68.9%, EN-LDA 56.8%, EN-KNN 49.7%, and EN-DT 36.5%. LDA had the highest test accuracy, reflecting the bias-variance tradeoff over the range of complexities inherent to the algorithms tested. Several algorithms were able to match the current standard in burn tissue classification, the clinical judgment of expert burn surgeons. These results will guide further development of an MSI burn tissue classification system. Given that there are few surgeons and facilities specializing in burn care

  19. Return to work among employees with common mental disorders : Study design and baseline findings from a mixed-method follow-up study

    NARCIS (Netherlands)

    Nielsen, Maj Britt D.; Bultmann, Ute; Amby, Malene; Christensen, Ulla; Diderichsen, Finn; Rugulies, Reiner

    2010-01-01

    Aims: Most research on return-to-work (RTW) has focused on musculoskeletal disorders. To study RTW in employees sick-listed with common mental disorders (CMD), e.g., stress, depression, and anxiety, the National Research Centre for the Working Environment initiated a study on ''Common Mental

  20. High Education as a Common Good in China: A Case Study for Ideas and Practice

    Science.gov (United States)

    Zhu, Jiangang

    2016-01-01

    China began its modern system of higher education with the establishment of the former Peking University in Beijing in 1898. The traditional Confucian philosophy of education has been replaced dramatically by modern western philosophy. However, since the communist party came to power in 1949, the philosophy of higher education has experienced many…

  1. Screening of some commonly used skin-lightening creams and soaps: a case study in Ghana

    International Nuclear Information System (INIS)

    Beni, C.T.; Maaku, B.T.; Akaho, E.H.K.

    2003-01-01

    Seven commonly used skin lightening creams (Body Claire, Peau claire, Akagni sivoclaire, Top gel, Tenovate and Movate) and five medicated soaps (Tura, Sukisa Bango, Crusader Safety, Movate Germicidal and Silver Rose) were investigated for the presence and levels of trace/heavy metals and hydroquinone in them. Instrumental Neutron Activation analysis (INAA) was used to identify and quantify the level of trace/heavy metals in these creams and soap samples. The analysis showed the presence in the creams of significant concentrations of Mn, Cd, Au, Sn, In, Sc, Hf, Ta, Ba, Nd, Sb, Al and Co. The medicated soaps contained significant concentrations of Hg, Co, Ce, Al, Hf and Ti. Thin Layer Chromatography (TLC) investigations revealed the presence of hydroquinones in Akagni and confirmed its presence also in Body Claire, Peau Claire and Sivoclaire but its absence in Tenovate, Top gel and Movate creams. Titration of the creams against Ce (IV) solution showed that hydroquinone levels in the Body Claire is 2.47%. Akagni is 4.92%, Peau Claire is 3.84% and Sivoclaire contains 4.03%. These levels are higher than the maximum 2% allowed by the Ghana Standards Board, the EEC directives of 1976 and the Cosmetic Production Regulation 1978 (UK) for product safety. (author)

  2. Crystallization and preliminary X-ray study of the common edible mushroom (Agaricus bisporus) lectin.

    Science.gov (United States)

    Carrizo, Maria E; Irazoqui, Fernando J; Lardone, Ricardo D; Nores, Gustavo A; Curtino, Juan A; Capaldi, Stefano; Perduca, Massimiliano; Monaco, Hugo L

    2004-04-01

    The lectin from the common edible mushroom Agaricus bisporus (ABL) belongs to the group of proteins that have the property of binding the Thomsen-Friedenreich antigen (T-antigen) selectively and with high affinity, but does not show any sequence similarity to the other proteins that share this property. The ABL sequence is instead similar to those of members of the saline-soluble fungal lectins, a protein family with pesticidal properties. The presence of different isoforms has been reported. It has been found that in order to be able to grow diffraction-quality crystals of the lectin, it is essential to separate the isoforms, which was performed by preparative isoelectric focusing. Using standard procedures, it was possible to crystallize the most basic of the forms by either vapour diffusion or equilibrium dialysis, but attempts to grow crystals of the other more acidic forms were unsuccessful. The ABL crystals belong to the orthorhombic space group C222(1), with unit-cell parameters a = 93.06, b = 98.16, c = 76.38 A, and diffract to a resolution of 2.2 A on a conventional source at room temperature. It is expected that the solution of this structure will yield further valuable information on the differences in the T-antigen-binding folds and will perhaps help to clarify the details of the ligand binding to the protein.

  3. Common Courses for Common Purposes:

    DEFF Research Database (Denmark)

    Schaub Jr, Gary John

    2014-01-01

    (PME)? I suggest three alternative paths that increased cooperation in PME at the level of the command and staff course could take: a Nordic Defence College, standardized national command and staff courses, and a core curriculum of common courses for common purposes. I conclude with a discussion of how...

  4. PV solar system feasibility study

    International Nuclear Information System (INIS)

    Ashhab, Moh’d Sami S.; Kaylani, Hazem; Abdallah, Abdallah

    2013-01-01

    Highlights: ► This research studies the feasibility of PV solar systems. ► The aim is to develop the theory and application of a hybrid system. ► Relevant research topics are reviewed and some of them are discussed in details. ► A prototype of the PV solar system is designed and built. - Abstract: This research studies the feasibility of PV solar systems and aims at developing the theory and application of a hybrid system that utilizes PV solar system and another supporting source of energy to provide affordable heating and air conditioning. Relevant research topics are reviewed and some of them are discussed in details. Solar heating and air conditioning research and technology exist in many developed countries. To date, the used solar energy has been proved to be inefficient. Solar energy is an abundant source of energy in Jordan and the Middle East; with increasing prices of oil this source is becoming more attractive alternative. A good candidate for the other system is absorption. The overall system is designed such that it utilizes solar energy as a main source. When the solar energy becomes insufficient, electricity or diesel source kicks in. A prototype of the PV solar system that operates an air conditioning unit is built and proper measurements are collected through a data logging system. The measured data are plotted and discussed, and conclusions regarding the system performance are extracted.

  5. QCI Common

    Energy Technology Data Exchange (ETDEWEB)

    2016-11-18

    There are many common software patterns and utilities for the ORNL Quantum Computing Institute that can and should be shared across projects. Otherwise we find duplication of code which adds unwanted complexity. This is a software product seeks to alleviate this by providing common utilities such as object factories, graph data structures, parameter input mechanisms, etc., for other software products within the ORNL Quantum Computing Institute. This work enables pure basic research, has no export controlled utilities, and has no real commercial value.

  6. Effects of partial dietary supplementation of fish meal with soymeal on the stress and apoptosis response in the digestive system of common dentex (Dentex dentex).

    Science.gov (United States)

    Antonopoulou, Efthimia; Chouri, Eleni; Feidantsis, Konstantinos; Lazou, Antigone; Chatzifotis, Stavros

    2017-12-01

    Soybean is a common alternative protein source of plant origin in aquafeeds as it has a reasonably balanced amino acid profile and is widely available. This study aimed to investigate the influence of partial substitution of fish meal with soy meal on cytoprotective pathways and apoptosis in the digestive system of common dentex ( Dentex dentex ), using the activation of Hsp70, p38 MAPK, Bcl-2 and caspase-3. The experimental approach involved feeding of common dentex with three isoprotein and isoenergetic diets that contained fish meal as a protein source (FM), partial replacement of fish meal by soy meal 25% (SM25) and 40% (SM40) for 3 months. The SM40 diet induced Hsp70 activation only in the middle part of intestine. On the other hand, both SM25 and SM40 diets diminished the phosphorylation of p38 MAPK in the anterior and the middle part of intestine, whereas only SM25 induced p38 MAPK phosphorylation in the stomach. Moreover, a decrease in the levels of caspase-3 activity was observed in the middle and posterior intestine, as well as in the stomach after feeding with SM25 diets. Furthermore, Bcl-2 levels were increased by SM40 in the anterior and by SM25 in the middle part of intestine. SM25 and SM40 diets elicited a tissue and soy concentration specific cellular and cell protective response in the different parts of the digestive tract in common dentex.

  7. Survey of strain-rate effects for some common structural materials used in radioactive material packaging and transportation systems

    International Nuclear Information System (INIS)

    Robinson, R.A.; Zielenbach, W.J.; Lawrence, A.A.

    1976-08-01

    In safety evaluation of radioactive material packaging and transport systems during accidents mechanical property data for the structural materials under impact conditions are needed in order to assess the damage and consequences of the accident. This document reviews the status of dynamic material property data for the following common structural materials: lead, uranium, stainless steels, steels, aluminum, copper, and brass. The strain rate data reviewed were limited to the range from static to dynamic impact velocities of 50 ft/s or strain rates of 10 2 /second; temperature conditions were limited to the range -40 to 1000 0 F. Purpose of this document is to explain the test methods, present some of the relevant data, and identify some of the needs for additional data. 7 tables, 14 figures, 77 references

  8. Sensitivity analysis on the effect of software-induced common cause failure probability in the computer-based reactor trip system unavailability

    International Nuclear Information System (INIS)

    Kamyab, Shahabeddin; Nematollahi, Mohammadreza; Shafiee, Golnoush

    2013-01-01

    Highlights: ► Importance and sensitivity analysis has been performed for a digitized reactor trip system. ► The results show acceptable trip unavailability, for software failure probabilities below 1E −4 . ► However, the value of Fussell–Vesley indicates that software common cause failure is still risk significant. ► Diversity and effective test is founded beneficial to reduce software contribution. - Abstract: The reactor trip system has been digitized in advanced nuclear power plants, since the programmable nature of computer based systems has a number of advantages over non-programmable systems. However, software is still vulnerable to common cause failure (CCF). Residual software faults represent a CCF concern, which threat the implemented achievements. This study attempts to assess the effectiveness of so-called defensive strategies against software CCF with respect to reliability. Sensitivity analysis has been performed by re-quantifying the models upon changing the software failure probability. Importance measures then have been estimated in order to reveal the specific contribution of software CCF in the trip failure probability. The results reveal the importance and effectiveness of signal and software diversity as applicable strategies to ameliorate inefficiencies due to software CCF in the reactor trip system (RTS). No significant change has been observed in the rate of RTS failure probability for the basic software CCF greater than 1 × 10 −4 . However, the related Fussell–Vesley has been greater than 0.005, for the lower values. The study concludes that consideration of risk associated with the software based systems is a multi-variant function which requires compromising among them in more precise and comprehensive studies

  9. Photosensitivity and photodynamic events in black, red and blue tattoos are common: A 'Beach Study'.

    Science.gov (United States)

    Hutton Carlsen, K; Serup, J

    2014-02-01

    To find the prevalence of complaints in people having tattoos, with emphasis on chronic complaints, photosensitivity and photodynamic events. Individuals sunbathing from June to September 2011 at the beaches of Denmark were invited to participate as they are prone to report tattoos and sun habits reliably. Sun-related and non-sun-related problems in tattoos were determined along with participants' use of sunscreen. Skin type was categorized, as were motifs and colours associated with problems. Of 467 sunbathers, 146 (31.3%) had tattoos. A total of 144 sunbathers with 301 tattoos accepted inclusion. Complaints were experienced in 60/144 (42%), of which 31/60 (52%) were sun related, such as swelling (58%), itching/stinging/pain (52%) and redness (26%). Reactions independent of sun were 29/60 (48%), such as reactions to heat 12/29 (41%) and cold 1/29 (4%). Red, blue and black tattoos predominantly caused sun-related complaints followed by the remaining colours. By number, problems in black tattoos dominated as black was far more frequent. Complaints such as swelling, itching, stinging, pain and redness are common, predominantly in black and red tattoos, but also frequent in blue tattoos, thus, not confined to one specific colour or chemical entity or class of pigment. Symptoms may switch on and off in seconds, typically not of the weal-and-flare type. Photochemical reactions to pigment or pigment-breakdown products in situ in the skin with induction of reactive oxygen species (ROS) is presumed to be one causative mechanism. Another possible mechanism especially relevant in black may be induction of ROS due to effects of aggregation of carbon black nanoparticles. © 2013 The Authors Journal of the European Academy of Dermatology and Venereology © 2013 European Academy of Dermatology and Venereology.

  10. Cerebral effects of commonly used vasopressor-inotropes: a study in newborn piglets.

    Directory of Open Access Journals (Sweden)

    Gitte H Hahn

    Full Text Available Despite widespread use in sick infants, it is still debated whether vasopressor-inotropes have direct cerebral effects that might affect neurological outcome. We aimed to test direct cerebrovascular effects of three commonly used vasopressor-inotropes (adrenaline, dopamine and noradrenaline by comparing the responses to those of nonpharmacologically induced increases in blood pressure. We also searched for reasons for a mismatch between the response in perfusion and oxygenation.Twenty-four piglets had long and short infusions of the three vasopressor-inotropes titrated to raise mean arterial blood pressure (MAP 10 mmHg in random order. Nonpharmacological increases in MAP were induced by inflation of a balloon in the descending aorta. We measured cerebral oxygenation (near-infrared spectroscopy, perfusion (laser-Doppler, oxygen consumption (co-oximetry of arterial and superior sagittal sinus blood, and microvascular heterogeneity (side stream dark field video microscopy.Vasopressor-inotropes increased cerebral oxygenation significantly less (p≤0.01 compared to non-pharmacological MAP increases, whereas perfusion was similar. Furthermore, cerebral total hemoglobin concentration increased significantly less during vasopressor-inotrope infusions (p = 0.001. These physiologic responses were identical between the three vasopressor-inotropes (p>0.05. Furthermore, they induced a mild, although insignificant increase in cerebral metabolism and microvascular heterogeneity (p>0.05. Removal of the scalp tissue did not influence the mismatch (p>0.05.We demonstrated a moderate vasopressor-inotrope induced mismatch between cerebral perfusion and oxygenation. Scalp removal did not affect this mismatch, why vasopressor-inotropes appear to have direct cerebral actions. The statistically nonsignificant increases in cerebral metabolism and/or microvascular heterogeneity may explain the mismatch. Alternatively, it may simply reflect a vasopressor

  11. Characteristics of pressure wave in common rail fuel injection system of high-speed direct injection diesel engines

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Herfatmanesh

    2016-05-01

    Full Text Available The latest generation of high-pressure common rail equipment now provides diesel engines possibility to apply as many as eight separate injection pulses within the engine cycle for reducing emissions and for smoothing combustion. With these complicated injection arrangements, optimizations of operating parameters for various driving conditions are considerably difficult, particularly when integrating fuel injection parameters with other operating parameters such as exhaust gas recirculation rate and boost pressure together for evaluating calibration results. Understanding the detailed effects of fuel injection parameters upon combustion characteristics and emission formation is therefore particularly critical. In this article, the results and discussion of experimental investigations on a high-speed direct injection light-duty diesel engine test bed are presented for evaluating and analyzing the effects of main adjustable parameters of the fuel injection system on all regulated emission gases and torque performance. Main injection timing, rail pressure, pilot amount, and particularly pilot timing have been examined. The results show that optimization of each of those adjustable parameters is beneficial for emission reduction and torque improvement under different operating conditions. By exploring the variation in the interval between the pilot injection and the main injection, it is found that the pressure wave in the common rail has a significant influence on the subsequent injection. This suggests that special attentions must be paid for adjusting pilot timing or any injection interval when multi-injection is used. With analyzing the fuel amount oscillation of the subsequent injections to pilot separation, it demonstrates that the frequency of regular oscillations of the actual fuel amount or the injection pulse width with the variation in pilot separation is always the same for a specified fuel injection system, regardless of engine speed

  12. Comment: The comparison study of 5 Fluorouracil vs. cryotherpy in the treatment of the backhand resistant common wart

    Directory of Open Access Journals (Sweden)

    Antonio Chuh

    2014-07-01

    Full Text Available We refer to the study conducted by Asghariazar R et al comparing the efficacy of 5-fluorouracil against cryotherapy in the management of backhand resistant common warts [1]. We congratulate their success in reporting such a high-quality study. We would humbly like to offer a few pieces of advice, which might further augment the clinical relevance and the scientific content for future studies along similar veins.

  13. Space station operating system study

    Science.gov (United States)

    Horn, Albert E.; Harwell, Morris C.

    1988-01-01

    The current phase of the Space Station Operating System study is based on the analysis, evaluation, and comparison of the operating systems implemented on the computer systems and workstations in the software development laboratory. Primary emphasis has been placed on the DEC MicroVMS operating system as implemented on the MicroVax II computer, with comparative analysis of the SUN UNIX system on the SUN 3/260 workstation computer, and to a limited extent, the IBM PC/AT microcomputer running PC-DOS. Some benchmark development and testing was also done for the Motorola MC68010 (VM03 system) before the system was taken from the laboratory. These systems were studied with the objective of determining their capability to support Space Station software development requirements, specifically for multi-tasking and real-time applications. The methodology utilized consisted of development, execution, and analysis of benchmark programs and test software, and the experimentation and analysis of specific features of the system or compilers in the study.

  14. An in vitro Study of the Effect of Some Commonly Used Antacids on ...

    African Journals Online (AJOL)

    User

    This study reports on the effect of magnesium oxide, magnesium trisilicate, aluminium hydroxide ... characteristics of commercial paracetamol and metronidazole tablets. The effect of salt on the interaction between the drugs and the antacids was also studied. The ... Most antacids, except sodium bicarbonate, may decrease ...

  15. How common is domestic violence against women? The definition of partner abuse in prevalence studies.

    Science.gov (United States)

    Hegarty, K; Roberts, G

    1998-02-01

    We systematically reviewed studies of the prevalence of domestic violence. Selected overseas community studies were compared with all Australian prevalence studies found to be published. Twelve-month prevalence estimates of partner abuse in Australia varied from 2.1 per cent to 28.0 per cent, depending mainly on the definition of domestic violence used in each study. Implications of the lack of a precise definition result in varying operationalised definitions of partner abuse, from all types of violence in relationships (including a single minor violent incident), through to only those violent incidents that are classified as a crime. Recommendations for any future prevalence studies in this field include the need to collect frequency data which reflected the fact that partner abuse against women is a complex behavioural phenomenon involving emotional, physical and sexual abuse against a partner, not just simply physical incidents.

  16. Relationship between common lipoprotein lipase gene sequence variants, hyperinsulinemia, and risk of ischemic heart disease: A population-based study

    DEFF Research Database (Denmark)

    Jeppesen, Jørgen; Hansen, Tine Willum; Torp-Pedersen, Christian

    2010-01-01

    Hyperinsulinemia and lipoprotein lipase (LPL) are important determinants of fasting and postprandial plasma triglyceride levels. High insulin and high triglyceride levels are associated with an increased risk of ischemic heart disease (IHD). This study aimed to find out whether common LPL gene se...... sequence variants could change the relationship between insulin and IHD....

  17. A Study of General Education Astronomy Students' Understandings of Cosmology. Part IV. Common Difficulties Students Experience with Cosmology

    Science.gov (United States)

    Wallace, Colin S.; Prather, Edward E.; Duncan, Douglas K.

    2012-01-01

    This is our fourth paper in our five paper series describing our national study of general education astronomy students' conceptual and reasoning difficulties with cosmology. While previous papers in this series focused on the processes by which we collected and quantitatively analyzed our data, this paper presents the most common pre-instruction…

  18. Common Core State Standards for Literacy in History/Social Studies, Science, and Technical Subjects for English Language Learners

    Science.gov (United States)

    de Oliveira, Luciana C., Ed.

    2016-01-01

    This volume in the Common Core State Standards (CCSS) for English Language Learners series was designed to deepen teacher's knowledge and provides instructional approaches and practices for supporting grades 6-12 ELLs as they meet the ambitious expectations of the CCSS for Literacy in History/Social Studies, Science, and Technical Subjects. This…

  19. Gender and age differences in the recurrence of sickness absence due to common mental disorders : a longitudinal study

    NARCIS (Netherlands)

    Koopmans, P.C.; Roelen, C.A.M.; Bultmann, U.; Hoedeman, R.; van der Klink, J.J.L.; Groothoff, J.W.

    2010-01-01

    Background: Common mental disorders (CMDs) are an important cause of sickness absence and long-term work disability. Although CMDs are known to have high recurrence rates, little is known about the recurrence of sickness absence due to CMDs. The aim of this study was to investigate the recurrence of

  20. A Comparative Study of Melanin Content and Skin Morphology for Three Commonly Used Laboratory Swine (Sus scrofa domestica)

    Science.gov (United States)

    2012-09-01

    Air Force Research Laboratory 711th Human Performance Wing Human Effectiveness Directorate Bioeffects Division Optical Radiation Bioeffects...Branch AFRL-RH-FS-TR-2013-0004 A Comparative Study of Melanin Content and Skin Morphology for Three Commonly Used Laboratory Swine (Sus scrofa...Jindra Human Effectiveness Directorate Directed Energy Bioeffects Division Optical Radiation Branch Robert W. Kornegay Rick Figueroa Human

  1. The Common Core State Standards: An Opportunity to Enhance Formative Assessment in History/Social Studies Classrooms

    Science.gov (United States)

    Ateh, Comfort M.; Wyngowski, Aaron J.

    2015-01-01

    This article discusses the opportunity that the Common Core State Standards (CCSS) present for enhancing formative assessment (FA) in history and social studies classrooms. There is evidence that FA can enhance learning for students if implemented well. Unfortunately, teachers continue to be challenged in implementing FA in their classrooms. We…

  2. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

    NARCIS (Netherlands)

    T. Tanaka (Toshiko); J.S. Ngwa; F.J.A. van Rooij (Frank); M.C. Zillikens (Carola); M.K. Wojczynski (Mary ); A.C. Frazier-Wood (Alexis); D.K. Houston (Denise); S. Kanoni (Stavroula); R.N. Lemaitre (Rozenn ); J. Luan; V. Mikkilä (Vera); F. Renström (Frida); E. Sonestedt (Emily); J.H. Zhao (Jing Hua); A.Y. Chu (Audrey); L. Qi (Lu); D.I. Chasman (Daniel); M.C. De Oliveira Otto (Marcia); E.J. Dhurandhar (Emily); M.F. Feitosa (Mary Furlan); I. Johansson (Ingegerd); K-T. Khaw (Kay-Tee); K. Lohman (Kurt); A. Manichaikul (Ani); N.M. McKeown (Nicola ); D. Mozaffarian (Dariush); A.B. Singleton (Andrew); K. Stirrups (Kathy); J. Viikari (Jorma); Z. Ye (Zheng); S. Bandinelli (Stefania); I.E. Barroso (Inês); P. Deloukas (Panagiotis); N.G. Forouhi (Nita); A. Hofman (Albert); Y. Liu (YongMei); L.-P. Lyytikäinen (Leo-Pekka); K.E. North (Kari); M. Dimitriou (Maria); G. Hallmans (Göran); M. Kähönen (Mika); C. Langenberg (Claudia); J.M. Ordovas (Jose); A.G. Uitterlinden (André); F.B. Hu (Frank); I.-P. Kalafati (Ioanna-Panagiota); O. Raitakari (Olli); O.H. Franco (Oscar); A. Johnson (Anthony); V. Emilsson (Valur); J.A. Schrack (Jennifer); R.D. Semba; D.S. Siscovick (David); D.K. Arnett (Donna); I.B. Borecki (Ingrid); P.W. Franks (Paul); S.B. Kritchevsky (Stephen); R.J.F. Loos (Ruth); M. Orho-Melander (Marju); J.I. Rotter (Jerome); N.J. Wareham (Nick); J.C.M. Witteman (Jacqueline); L. Ferrucci (Luigi); G.V. Dedoussis (George); L.A. Cupples (Adrienne); J.A. Nettleton (Jennifer )

    2013-01-01

    textabstractBackground: Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants. Objective: The objective of the study was to identify common genetic variants that are associated with macronutrient intake.

  3. Investigating the Language Demands in the Common Core State Standards for English Language Learners: A Comparison Study of Standards

    Science.gov (United States)

    Wolf, Mikyung Kim; Wang, Yuan; Huang, Becky H.; Blood, Ian

    2014-01-01

    This study reports on a critical review of the language demands contained in the Common Core State Standards for English language arts (CCSS-ELA) with the aim of deriving important implications for the instruction of English language learners. The language demands of the CCSS-ELA were compared with those of existing English language arts (ELA) and…

  4. Local exome sequences facilitate imputation of less common variants and increase power of genome wide association studies.

    Directory of Open Access Journals (Sweden)

    Peter K Joshi

    Full Text Available The analysis of less common variants in genome-wide association studies promises to elucidate complex trait genetics but is hampered by low power to reliably detect association. We show that addition of population-specific exome sequence data to global reference data allows more accurate imputation, particularly of less common SNPs (minor allele frequency 1-10% in two very different European populations. The imputation improvement corresponds to an increase in effective sample size of 28-38%, for SNPs with a minor allele frequency in the range 1-3%.

  5. Validation of Patient-Reported Outcomes Measurement Information System Computerized Adaptive Tests Against the Foot and Ankle Outcome Score for 6 Common Foot and Ankle Pathologies.

    Science.gov (United States)

    Koltsov, Jayme C B; Greenfield, Stephen T; Soukup, Dylan; Do, Huong T; Ellis, Scott J

    2017-08-01

    The field of foot and ankle surgery lacks a widely accepted gold-standard patient-reported outcome instrument. With the changing infrastructure of the medical profession, more efficient patient-reported outcome tools are needed to reduce respondent burden and increase participation while providing consistent and reliable measurement across multiple pathologies and disciplines. The primary purpose of the present study was to validate 3 Patient-Reported Outcomes Measurement Information System computer adaptive tests (CATs) most relevant to the foot and ankle discipline against the Foot and Ankle Outcome Score (FAOS) and the Short Form 12 general health status survey in patients with 6 common foot and ankle pathologies. Patients (n = 240) indicated for operative treatment for 1 of 6 common foot and ankle pathologies completed the CATs, FAOS, and Short Form 12 at their preoperative surgical visits, 1 week subsequently (before surgery), and at 6 months postoperatively. The psychometric properties of the instruments were assessed and compared. The Patient-Reported Outcomes Measurement Information System CATs each took less than 1 minute to complete, whereas the FAOS took 6.5 minutes, and the Short Form 12 took 3 minutes. CAT scores were more normally distributed and had fewer floor and ceiling effects than those on the FAOS, which reached as high as 24%. The CATs were more precise than the FAOS and had similar responsiveness and test-retest reliability. The physical function and mobility CATs correlated strongly with the activities subscale of the FAOS, and the pain interference CAT correlated strongly with the pain subscale of the FAOS. The CATs and FAOS were responsive to changes with operative treatment for 6 common foot and ankle pathologies. The CATs performed as well as or better than the FAOS in all aspects of psychometric validity. The Patient-Reported Outcomes Measurement Information System CATs show tremendous potential for improving the study of patient

  6. A comparative study for plaque removing efficacy between commonly used denture cleansers in India

    Directory of Open Access Journals (Sweden)

    Bhushan Kumar

    2017-01-01

    Conclusions: There was no significant difference among action of four denture cleansers used in this study. Thus we can infer that patients can use liquid handwashing soap or commercial products to overcome disadvantages of toothpastes. Recommendation from the results of this study is the use of liquid handwashing soap for cleansing after every meal and soaking of the denture in commercial denture cleanser during the night.

  7. Sampling strategies to measure the prevalence of common recurrent infections in longitudinal studies

    Directory of Open Access Journals (Sweden)

    Luby Stephen P

    2010-08-01

    Full Text Available Abstract Background Measuring recurrent infections such as diarrhoea or respiratory infections in epidemiological studies is a methodological challenge. Problems in measuring the incidence of recurrent infections include the episode definition, recall error, and the logistics of close follow up. Longitudinal prevalence (LP, the proportion-of-time-ill estimated by repeated prevalence measurements, is an alternative measure to incidence of recurrent infections. In contrast to incidence which usually requires continuous sampling, LP can be measured at intervals. This study explored how many more participants are needed for infrequent sampling to achieve the same study power as frequent sampling. Methods We developed a set of four empirical simulation models representing low and high risk settings with short or long episode durations. The model was used to evaluate different sampling strategies with different assumptions on recall period and recall error. Results The model identified three major factors that influence sampling strategies: (1 the clustering of episodes in individuals; (2 the duration of episodes; (3 the positive correlation between an individual's disease incidence and episode duration. Intermittent sampling (e.g. 12 times per year often requires only a slightly larger sample size compared to continuous sampling, especially in cluster-randomized trials. The collection of period prevalence data can lead to highly biased effect estimates if the exposure variable is associated with episode duration. To maximize study power, recall periods of 3 to 7 days may be preferable over shorter periods, even if this leads to inaccuracy in the prevalence estimates. Conclusion Choosing the optimal approach to measure recurrent infections in epidemiological studies depends on the setting, the study objectives, study design and budget constraints. Sampling at intervals can contribute to making epidemiological studies and trials more efficient, valid

  8. A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer.

    Science.gov (United States)

    Schwartzman, Jacob; Mongoue-Tchokote, Solange; Gibbs, Angela; Gao, Lina; Corless, Christopher L; Jin, Jennifer; Zarour, Luai; Higano, Celestia; True, Lawrence D; Vessella, Robert L; Wilmot, Beth; Bottomly, Daniel; McWeeney, Shannon K; Bova, G Steven; Partin, Alan W; Mori, Motomi; Alumkal, Joshi

    2011-10-01

    DNA methylation of promoter regions is a common event in prostate cancer, one of the most common cancers in men worldwide. Because prior reports demonstrating that DNA methylation is important in prostate cancer studied a limited number of genes, we systematically quantified the DNA methylation status of 1505 CpG dinucleotides for 807 genes in 78 paraffin-embedded prostate cancer samples and three normal prostate samples. The ERG gene, commonly repressed in prostate cells in the absence of an oncogenic fusion to the TMPRSS2 gene, was one of the most commonly methylated genes, occurring in 74% of prostate cancer specimens. In an independent group of patient samples, we confirmed that ERG DNA methylation was common, occurring in 57% of specimens, and cancer-specific. The ERG promoter is marked by repressive chromatin marks mediated by polycomb proteins in both normal prostate cells and prostate cancer cells, which may explain ERG's predisposition to DNA methylation and the fact that tumors with ERG DNA methylation were more methylated, in general. These results demonstrate that bead arrays offer a high-throughput method to discover novel genes with promoter DNA methylation such as ERG, whose measurement may improve our ability to more accurately detect prostate cancer.

  9. Genome-Wide Association Studies of Anthracnose and Angular Leaf Spot Resistance in Common Bean (Phaseolus vulgaris L..

    Directory of Open Access Journals (Sweden)

    Juliana Morini Küpper Cardoso Perseguini

    Full Text Available The common bean (Phaseolus vulgaris L. is the world's most important legume for human consumption. Anthracnose (ANT; Colletotrichum lindemuthianum and angular leaf spot (ALS; Pseudocercospora griseola are complex diseases that cause major yield losses in common bean. Depending on the cultivar and environmental conditions, anthracnose and angular leaf spot infections can reduce crop yield drastically. This study aimed to estimate linkage disequilibrium levels and identify quantitative resistance loci (QRL controlling resistance to both ANT and ALS diseases of 180 accessions of common bean using genome-wide association analysis. A randomized complete block design with four replicates was performed for the ANT and ALS experiments, with four plants per genotype in each replicate. Association mapping analyses were performed for ANT and ALS using a mixed linear model approach implemented in TASSEL. A total of 17 and 11 significant statistically associations involving SSRs were detected for ANT and ALS resistance loci, respectively. Using SNPs, 21 and 17 significant statistically associations were obtained for ANT and angular ALS, respectively, providing more associations with this marker. The SSR-IAC167 and PvM95 markers, both located on chromosome Pv03, and the SNP scaffold00021_89379, were associated with both diseases. The other markers were distributed across the entire common bean genome, with chromosomes Pv03 and Pv08 showing the greatest number of loci associated with ANT resistance. The chromosome Pv04 was the most saturated one, with six markers associated with ALS resistance. The telomeric region of this chromosome showed four markers located between approximately 2.5 Mb and 4.4 Mb. Our results demonstrate the great potential of genome-wide association studies to identify QRLs related to ANT and ALS in common bean. The results indicate a quantitative and complex inheritance pattern for both diseases in common bean. Our findings will

  10. Genome-Wide Association Studies of Anthracnose and Angular Leaf Spot Resistance in Common Bean (Phaseolus vulgaris L.).

    Science.gov (United States)

    Perseguini, Juliana Morini Küpper Cardoso; Oblessuc, Paula Rodrigues; Rosa, João Ricardo Bachega Feijó; Gomes, Kleber Alves; Chiorato, Alisson Fernando; Carbonell, Sérgio Augusto Morais; Garcia, Antonio Augusto Franco; Vianello, Rosana Pereira; Benchimol-Reis, Luciana Lasry

    2016-01-01

    The common bean (Phaseolus vulgaris L.) is the world's most important legume for human consumption. Anthracnose (ANT; Colletotrichum lindemuthianum) and angular leaf spot (ALS; Pseudocercospora griseola) are complex diseases that cause major yield losses in common bean. Depending on the cultivar and environmental conditions, anthracnose and angular leaf spot infections can reduce crop yield drastically. This study aimed to estimate linkage disequilibrium levels and identify quantitative resistance loci (QRL) controlling resistance to both ANT and ALS diseases of 180 accessions of common bean using genome-wide association analysis. A randomized complete block design with four replicates was performed for the ANT and ALS experiments, with four plants per genotype in each replicate. Association mapping analyses were performed for ANT and ALS using a mixed linear model approach implemented in TASSEL. A total of 17 and 11 significant statistically associations involving SSRs were detected for ANT and ALS resistance loci, respectively. Using SNPs, 21 and 17 significant statistically associations were obtained for ANT and angular ALS, respectively, providing more associations with this marker. The SSR-IAC167 and PvM95 markers, both located on chromosome Pv03, and the SNP scaffold00021_89379, were associated with both diseases. The other markers were distributed across the entire common bean genome, with chromosomes Pv03 and Pv08 showing the greatest number of loci associated with ANT resistance. The chromosome Pv04 was the most saturated one, with six markers associated with ALS resistance. The telomeric region of this chromosome showed four markers located between approximately 2.5 Mb and 4.4 Mb. Our results demonstrate the great potential of genome-wide association studies to identify QRLs related to ANT and ALS in common bean. The results indicate a quantitative and complex inheritance pattern for both diseases in common bean. Our findings will contribute to more

  11. Common methodologies in the evaluation of food allergy: pitfalls and prospects of food allergy prevalence studies.

    Science.gov (United States)

    Shu, Shang-an; Chang, Christopher; Leung, Patrick S C

    2014-06-01

    Global and regional studies on the prevalence of food allergies are plagued by inconsistent methodologies, variations in interpretation of results, and non-standardized study design. Hence, it becomes difficult to compare the prevalence of food allergies in different communities. This information would be useful in providing critical data that will enhance research to elucidate the nature of food allergies, and the role of gene-environment interactions in the sensitization of children and adults to foods. Testing methodologies range from questionnaires to objective in vitro and in vivo testing, to the gold standard, double-blind placebo-controlled food challenge (DBPCFC). Although considered the most accurate and reliable method in detecting the prevalence of food allergy, DBPCFC is not always practical in epidemiological studies of food allergy. On the other hand, multiple logistic regression studies have been done to determine predictability of the outcome of food challenges, and it appears that skin prick testing and in vitro-specific serum IgE are the best predictors. Future studies directed towards confirming the validity of these methods as well as developing algorithms to predict the food challenge outcomes are required, as they may someday become accessory tools to complement DBPCFC.

  12. Common ERBB2 polymorphisms and risk of breast cancer in a white British population: a case–control study

    International Nuclear Information System (INIS)

    Benusiglio, Patrick R; Ponder, Bruce AJ; Lesueur, Fabienne; Luccarini, Craig; Conroy, Donald M; Shah, Mitul; Easton, Douglas F; Day, Nick E; Dunning, Alison M; Pharoah, Paul D

    2005-01-01

    About two-thirds of the excess familial risk associated with breast cancer is still unaccounted for and may be explained by multiple weakly predisposing alleles. A gene thought to be involved in low-level predisposition to the disease is ERBB2 (HER2). This gene is involved in cell division, differentiation, and apoptosis and is frequently amplified in breast tumours. Its amplification correlates with poor prognosis. Moreover, the coding polymorphism I655V has previously been associated with an increased risk of breast cancer. We aimed to determine if common polymorphisms (frequency ≥ 5%) in ERBB2 were associated with breast cancer risk in a white British population. Five single-nucleotide polymorphisms (SNPs) were selected for study: SNP 1 near the promoter, SNP 2 in intron 1, SNP 3 in intron 4, SNP 4 in exon 17 (I655V), and SNP 5 in exon 27 (A1170P). We tested their association with breast cancer in a large case–control study (n = 2192 cases and 2257 controls). There were no differences in genotype frequencies between cases and controls for any of the SNPs examined. To investigate the possibility that a common polymorphism not included in our study might be involved in breast cancer predisposition, we also constructed multilocus haplotypes. Our set of SNPs generated all existing (n = 6) common haplotypes and no differences were seen in haplotype frequencies between cases and controls (P = 0.44). In our population, common ERBB2 polymorphisms are not involved in predisposition to breast cancer

  13. Creative Commons

    DEFF Research Database (Denmark)

    Jensen, Lone

    2006-01-01

    En Creative Commons licens giver en forfatter mulighed for at udbyde sit værk i en alternativ licensløsning, som befinder sig på forskellige trin på en skala mellem yderpunkterne "All rights reserved" og "No rights reserved". Derved opnås licensen "Some rights reserved"......En Creative Commons licens giver en forfatter mulighed for at udbyde sit værk i en alternativ licensløsning, som befinder sig på forskellige trin på en skala mellem yderpunkterne "All rights reserved" og "No rights reserved". Derved opnås licensen "Some rights reserved"...

  14. Science commons

    CERN Multimedia

    CERN. Geneva

    2007-01-01

    SCP: Creative Commons licensing for open access publishing, Open Access Law journal-author agreements for converting journals to open access, and the Scholar's Copyright Addendum Engine for retaining rights to self-archive in meaningful formats and locations for future re-use. More than 250 science and technology journals already publish under Creative Commons licensing while 35 law journals utilize the Open Access Law agreements. The Addendum Engine is a new tool created in partnership with SPARC and U.S. universities. View John Wilbanks's biography

  15. Framing the International Studies Curriculum: Toward the Development of Common Student Learning Outcomes

    Science.gov (United States)

    Chernotsky, Harry I.

    2013-01-01

    Unlike most disciplinary-based academic programs, interdisciplinary international studies programs vary considerably in terms of their core curricula. They need to fit within the institutional context in which they operate and must insure that there are sufficient faculty and resources available so that required courses are accessible on a regular…

  16. Work-Focused Treatment of Common Mental Disorders and Return to Work: A Comparative Outcome Study

    NARCIS (Netherlands)

    Lagerveld, S.E.; Blonk, R.W.B.; Brenninkmeijer, V.; Wijngaards-de Meij, L.; Schaufeli, W.B.

    2012-01-01

    The aim of this study was to compare the effectiveness of two individual-level psychotherapy interventions: (a) treatment as usual consisting of cognitive– behavioral therapy (CBT) and (b) work-focused CBT (W-CBT) that integrated work aspects early into the treatment. Both interventions were carried

  17. Finding Commonalities: Social Information Processing and Domain Theory in the Study of Aggression

    Science.gov (United States)

    Nucci, Larry

    2004-01-01

    The Arsenio and Lemerise (this issue) proposal integrating social information processing (SIP) and domain theory to study children's aggression is evaluated from a domain theory perspective. Basic tenets of domain theory rendering it compatible with SIP are discussed as well as points of divergence. Focus is directed to the proposition that…

  18. Optimization of Dose and Image Quality in Full-fiand Computed Radiography Systems for Common Digital Radiographic Examinations

    Directory of Open Access Journals (Sweden)

    Soo-Foon Moey

    2018-01-01

    Full Text Available IntroductionA fine balance of image quality and radiation dose can be achieved by optimization to minimize stochastic and deterministic effects. This study aimed in ensuring that images of acceptable quality for common radiographic examinations in digital imaging were produced without causing harmful effects. Materials and MethodsThe study was conducted in three phases. The pre-optimization involved ninety physically abled patients aged between 20 to 60 years and weighed between 60 and 80 kilograms for four common digital radiographic examinations. Kerma X_plus, DAP meter was utilized to measure the entrance surface dose (ESD while effective dose (ED was estimated using CALDose_X 5.0 Monte Carlo software. The second phase, an experimental study utilized an anthropomorphic phantom (PBU-50 and Leeds test object TOR CDR for relative comparison of image quality. For the optimization phase, the imaging parameters with acceptable image quality and lowest ESD from the experimental study was related to patient’s body thickness. Image quality were evaluated by two radiologists using the modified evaluation criteria score lists. ResultsSignificant differences were found for image quality for all examinations. However significant difference for ESD were found for PA chest and AP abdomen only. The ESD for three of the examinations were lower than all published data. Additionally, the ESD and ED obtained for all examinations were lower than that recommended by radiation regulatory bodies. ConclusionOptimization of image quality and dose was achieved by utilizing an appropriate tube potential, calibrated automatic exposure control and additional filtration of 0.2mm copper.

  19. Maternal common mental disorders and associated factors: a cross-sectional study in an urban slum area of Dhaka, Bangladesh

    OpenAIRE

    Khan, Ahad Mahmud; Flora, Meerjady Sabrina

    2017-01-01

    Background Poor maternal mental health has a negative impact on child growth and development. The objective of the study was to find out the associated factors of maternal common mental disorders (CMD) in an urban slum area of Bangladesh. Methods This cross-sectional study was carried out from September to November 2013 among conveniently selected 264 mothers having under-five children at Kamrangirchar area of Dhaka. A structured questionnaire based on Self-Reporting Questionnaire-20 (SRQ-20)...

  20. Nuclear right and South Market Common : health citizen protection and environment: comparative study Mercosur situation:critical analysis Uruguay situation

    International Nuclear Information System (INIS)

    Puig, D

    1998-01-01

    The present work presents to general study on: the applications of nuclear techniques, technical fundamental for stablishment of to program of radiation protection, to comparative study legislation in radiation protection in the South Market Common (MERCOSUR)Argentina,Brazil,Paraguay,Uruguay as well as Treaties and Agreements. The author carries out a critical analysis from the situation to Institutional level in the Uruguay and it outlines some alternatives to improve the situation [es