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Sample records for symposium sister chromatid

  1. Sister chromatid cohesion and recombination in meiosis

    NARCIS (Netherlands)

    Heemst, van D.; Heyting, C.

    2000-01-01

    Sister chromatids are associated from their formation until their disjunction. Cohesion between sister chromatids is provided by protein complexes, of which some components are conserved across the kingdoms and between the mitotic and meiotic cell cycles. Sister chromatid cohesion is intimately

  2. Review of the international symposium, sister chromatid exchanges: twenty-five years of experimental research

    International Nuclear Information System (INIS)

    Tice, R.R.; Lambert, B.; Morimoto, Kanehisa; Hollaender, A.

    1983-01-01

    The purpose of this symposium was to honor initial research at Brookhaven by bringing internationally recognized leaders in the fields of genetics, cytogenetics, carcinogenesis, mutagenesis, radiation biology, toxicology, and environmental health together into an open forum to present and discuss: (1) current knowledge of the induction and formation of SCEs and their relationship to other biological endpoints, including carcinogenesis, mutagenesis, transformation, clastogenesis, DNA damage and repair, and cellular toxicity; (2) the optimal strategies for the utilization of SCEs in genetic toxicology testing schemes involving in vitro and in vivo exposure situations; (3) the most valid statistical methods for analyzing SCE data obtained from cells in culture, from cells in intact organisms, and from cells in humans; (4) the relevance of SCEs as an indicator of human disease states, both inherited and acquired, and of progress in disease treatment; and (5) the use of SCEs as an indicator of human exposure to genotoxic agents and their relevance as a prognosticator of future adverse health outcomes. This report summarizes the presentations. 7 references

  3. Review of the international symposium, sister chromatid exchanges: twenty-five years of experimental research

    Energy Technology Data Exchange (ETDEWEB)

    Tice, R.R.; Lambert, B.; Morimoto, Kanehisa; Hollaender, A.

    1983-01-01

    The purpose of this symposium was to honor initial research at Brookhaven by bringing internationally recognized leaders in the fields of genetics, cytogenetics, carcinogenesis, mutagenesis, radiation biology, toxicology, and environmental health together into an open forum to present and discuss: (1) current knowledge of the induction and formation of SCEs and their relationship to other biological endpoints, including carcinogenesis, mutagenesis, transformation, clastogenesis, DNA damage and repair, and cellular toxicity; (2) the optimal strategies for the utilization of SCEs in genetic toxicology testing schemes involving in vitro and in vivo exposure situations; (3) the most valid statistical methods for analyzing SCE data obtained from cells in culture, from cells in intact organisms, and from cells in humans; (4) the relevance of SCEs as an indicator of human disease states, both inherited and acquired, and of progress in disease treatment; and (5) the use of SCEs as an indicator of human exposure to genotoxic agents and their relevance as a prognosticator of future adverse health outcomes. This report summarizes the presentations. 7 references. (ACR)

  4. Mechanisms of sister chromatid recombination

    International Nuclear Information System (INIS)

    Nakai, Sayaka; Machida, Isamu; Tsuji, Satsuki

    1985-01-01

    Studies using T948 as a model system have been carried out aimed at elucidating the mechanism of sister chromatid recombination (SCR). Characterization of U.V. light- and x-ray-induced SCR, the relationiship between SCR induction and DNA repair using rad mutations, and the relationship between SCR induction and the time of cell division using cdc mutations are presented. It has been supposed that SCR is induced at the phase of S-G 2 following DNA replication, that postreplication break of DNA strands is strongly involved in the induction of SCR, and that induction type of SCR, i.e., conversion type or recombination type, is dependent upon the type of molecular damage of DNA. (Namekawa, K.)

  5. Mechanics of Sister Chromatids studied with a Polymer Model

    Directory of Open Access Journals (Sweden)

    Yang eZhang

    2013-10-01

    Full Text Available Sister chromatid cohesion denotes the phenomenon that sister chromatids are initially attached to each other in mitosis to guarantee the error-free distribution into the daughter cells. Cohesion is mediated by binding proteins and only resolved after mitotic chromosome condensation is completed. However, the amount of attachement points required to maintain sister chromatid cohesion while still allowing proper chromosome condensation is not known yet. Additionally the impact of cohesion on the mechanical properties of chromosomes also poses an interesting problem. In this work we study the conformational and mechanical properties of sister chromatids by means of computer simulations. We model both protein-mediated cohesion between sister chromatids and chromosome condensation with a dynamic binding mechanisms. We show in a phase diagram that only specific link concentrations lead to connected and fully condensed chromatids that do not intermingle with each other nor separate due to entropic forces. Furthermore we show that dynamic bonding between chromatids decrease the Young's modulus compared to non-bonded chromatids.

  6. Precocious Sister Chromatid Separation (PSCS) in Cornelia de Lange Syndrome

    Science.gov (United States)

    Kaur, Maninder; DeScipio, Cheryl; McCallum, Jennifer; Yaeger, Dinah; Devoto, Marcella; Jackson, Laird G.; Spinner, Nancy B.; Krantz, Ian D.

    2009-01-01

    The Cornelia de Lange syndrome (CdLS) (OMIM# 122470) is a dominantly inherited multisystem developmental disorder. The phenotype consists of characteristic facial features, hirsutism, abnormalities of the upper extremities ranging from subtle changes in the phalanges and metacarpal bones to oligodactyly and phocomelia, gastroesophageal dysfunction, growth retardation, and neurodevelopmental delay. Prevalence is estimated to be as high as 1 in 10,000. Recently, mutations in NIPBL were identified in sporadic and familial CdLS cases. To date, mutations in this gene have been identified in over 45% of individuals with CdLS. NIPBL is the human homolog of the Drosophila Nipped-B gene. Although its function in mammalian systems has not yet been elucidated, sequence homologs of Nipped-B in yeast (Scc2 and Mis4) are required for sister chromatid cohesion during mitosis, and a similar role was recently demonstrated for Nipped-B in Drosophila. In order to evaluate NIPBL role in sister chromatid cohesion in humans, metaphase spreads on 90 probands (40 NIPBL mutation positive and 50 NIPBL mutation negative) with CdLS were evaluated for evidence of precocious sister chromatid separation (PSCS). We screened 50 metaphases from each proband and found evidence of PSCS in 41% (compared to 9% in control samples). These studies indicate that NIPBL may play a role in sister chromatid cohesion in humans as has been reported for its homologs in Drosophila and yeast. PMID:16100726

  7. ORIGINAL ARTICLE Sister chromatid exchange in peripheral blood ...

    African Journals Online (AJOL)

    salah

    mutations and more recently, CGH and multicolor fluorescence in situ hybrid- ization (M-FISH) have been applied to identify many gains and losses of DNA sequences and loci in breast tumors.1. The phenomenon of sister chromatid exchange (SCE) is a symmetrical ex- change of apparently identical portions.

  8. Sister chromatid exchange in peripheral blood lymphocytes as a ...

    African Journals Online (AJOL)

    Introduction: Sister chromatid exchanges (SCEs) can be induced by various genotoxic treatments, suggesting that SCEs refl ect a DNA repair process and it may be a good index for assessment of genomic instability. However, the occurrence of genetic instability and in particular, of spontaneous SCEs has been strongly ...

  9. Meiotic sister chromatid cohesion and recombination in two filamentous fungi

    NARCIS (Netherlands)

    Heemst, van D.

    2000-01-01

    Homologous recombination and sister chromatid cohesion play important roles in the maintenance of genome integrity and the fidelity of chromosome segregation in mitosis and meiosis. Within the living cell, the integrity of the DNA is threatened by various factors that cause DNA-lesions, of

  10. Enhancement of sister-chromatid exchanges by tumour promoters.

    OpenAIRE

    Ray-Chaudhuri, R.; Currens, M.; Iype, P. T.

    1982-01-01

    The effect of the tumour promoters TPA, phenobarbitone and saccharin on the production of sister-chromatid exchanges (SCE) was studied. TPA produced a small but significant increase of SCE in Chinese hamster cell lines V-79 and CHO, and in a hybrid clone formed by fusion of CHO with rat liver epithelial cells. The enhancement of SCE by TPA was not affected by the type of culture medium, heat-inactivated bovine serum, or the batch of TPA. In the presence of exogenous L-cysteine the enhancement...

  11. Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination

    NARCIS (Netherlands)

    Revenkova, E.; Eijpe, M.; Heyting, C.; Hodges, C.A.; Hunt, P.A.; Liebe, B.; Scherthan, H.; Jessberger, R.

    2004-01-01

    Sister chromatid cohesion ensures the faithful segregation of chromosomes in mitosis and in both meiotic divisions1, 2, 3, 4. Meiosis-specific components of the cohesin complex, including the recently described SMC1 isoform SMC15, were suggested to be required for meiotic sister chromatid cohesion

  12. Enhancement of sister-chromatid exchanges by tumour promoters.

    Science.gov (United States)

    Ray-Chaudhuri, R.; Currens, M.; Iype, P. T.

    1982-01-01

    The effect of the tumour promoters TPA, phenobarbitone and saccharin on the production of sister-chromatid exchanges (SCE) was studied. TPA produced a small but significant increase of SCE in Chinese hamster cell lines V-79 and CHO, and in a hybrid clone formed by fusion of CHO with rat liver epithelial cells. The enhancement of SCE by TPA was not affected by the type of culture medium, heat-inactivated bovine serum, or the batch of TPA. In the presence of exogenous L-cysteine the enhancement of SCE was reduced. TPA also increase the uptake of 2-deoxyglucose by the cells, to an extent similar to that of the SCE enhancement. This enhancement of SCE by TPA may be explained partly through the formation of free radicals, and partly through alterations in the cell-surface membrane and/or a transient delay in the cell-cycle progression. The other tumour promoters, phenobarbitone and saccharin, also enhanced both SCE and the uptake of 2-deoxyglucose in V-79 cells. PMID:7082559

  13. Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes

    OpenAIRE

    Pongsavee Malinee

    2009-01-01

    Abstract Background Borax is used as a food additive. It becomes toxic when accumulated in the body. It causes vomiting, fatigue and renal failure. Methods The heparinized blood samples from 40 healthy men were studied for the impact of borax toxicity on immune cell proliferation (lymphocyte proliferation) and sister chromatid exchange in human chromosomes. The MTT assay and Sister Chromatid Exchange (SCE) technic were used in this experiment with the borax concentrations of 0.1, 0.15, 0.2, 0...

  14. Saccharin-induced sister chromatid exchanges in Chinese hamster and human cells

    Energy Technology Data Exchange (ETDEWEB)

    Wolff, S.; Rodin, B.

    1978-05-05

    Since the induction of sister chromatid exchanges in cultured cells has been shown to be the most sensitive mammalian system to detect the effects of mutagenic carcinogens, Chinese hamster ovary cells and human lymphocytes were exposed to the sodium saccharin found to induce bladder cancer in rats. Both that saccharin and a highly purified extract of it increased the yield of sister chromatid exchanges in both types of cells. The results, which were repeatable and statistically highly significant, indicated that the weak carcinogen, saccharin, is also mutagenic in the sense that it induces cytogenetic changes.

  15. Genome-wide mapping of sister chromatid exchange events in single yeast cells using Strand-seq

    NARCIS (Netherlands)

    Claussin, Clemence; Porubsky, David; Spierings, Diana C. J.; Halsema, Nancy; Rentas, Stefan; Guryev, Victor; Lansdorp, Peter M.; Chang, Michael

    2017-01-01

    Homologous recombination involving sister chromatids is the most accurate, and thus most frequently used, form of recombination-mediated DNA repair. Despite its importance, sister chromatid recombination is not easily studied because it does not result in a change in DNA sequence, making

  16. Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes.

    Science.gov (United States)

    Pongsavee, Malinee

    2009-10-30

    Borax is used as a food additive. It becomes toxic when accumulated in the body. It causes vomiting, fatigue and renal failure. The heparinized blood samples from 40 healthy men were studied for the impact of borax toxicity on immune cell proliferation (lymphocyte proliferation) and sister chromatid exchange in human chromosomes. The MTT assay and Sister Chromatid Exchange (SCE) technic were used in this experiment with the borax concentrations of 0.1, 0.15, 0.2, 0.3 and 0.6 mg/ml. It showed that the immune cell proliferation (lymphocyte proliferation) was decreased when the concentrations of borax increased. The borax concentration of 0.6 mg/ml had the most effectiveness to the lymphocyte proliferation and had the highest cytotoxicity index (CI). The borax concentrations of 0.15, 0.2, 0.3 and 0.6 mg/ml significantly induced sister chromatid exchange in human chromosomes (P Borax had effects on immune cell proliferation (lymphocyte proliferation) and induced sister chromatid exchange in human chromosomes. Toxicity of borax may lead to cellular toxicity and genetic defect in human.

  17. Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes

    Directory of Open Access Journals (Sweden)

    Pongsavee Malinee

    2009-10-01

    Full Text Available Abstract Background Borax is used as a food additive. It becomes toxic when accumulated in the body. It causes vomiting, fatigue and renal failure. Methods The heparinized blood samples from 40 healthy men were studied for the impact of borax toxicity on immune cell proliferation (lymphocyte proliferation and sister chromatid exchange in human chromosomes. The MTT assay and Sister Chromatid Exchange (SCE technic were used in this experiment with the borax concentrations of 0.1, 0.15, 0.2, 0.3 and 0.6 mg/ml. Results It showed that the immune cell proliferation (lymphocyte proliferation was decreased when the concentrations of borax increased. The borax concentration of 0.6 mg/ml had the most effectiveness to the lymphocyte proliferation and had the highest cytotoxicity index (CI. The borax concentrations of 0.15, 0.2, 0.3 and 0.6 mg/ml significantly induced sister chromatid exchange in human chromosomes (P Conclusion Borax had effects on immune cell proliferation (lymphocyte proliferation and induced sister chromatid exchange in human chromosomes. Toxicity of borax may lead to cellular toxicity and genetic defect in human.

  18. Bromodeoxyuridine does not contribute to sister chromatid exchange events in normal or Bloom syndrome cells

    NARCIS (Netherlands)

    van Wietmarschen, Niek; Lansdorp, Peter M.

    2016-01-01

    Sister chromatid exchanges (SCEs) are considered sensitive indicators of genome instability. Detection of SCEs typically requires cells to incorporate bromodeoxyuridine (BrdU) during two rounds of DNA synthesis. Previous studies have suggested that SCEs are induced by DNA replication over

  19. Comparison of genome stability in two pig breeds by using the sister chromatid exchange (SCE test

    Directory of Open Access Journals (Sweden)

    V. Barbieri

    2010-01-01

    Full Text Available The sister chromatid exchange (SCE test has been used to detect genome stability in humans (Chaganti, 1974 and the main livestock species (Ciotola et al., 2004; Di Meo et al., 2000; Di Berardino et al., 1979, and to discover DNA damage caused by a variety of natural and artificial chemical compounds (Iannuzzi et al., 1990.

  20. Histone Chaperone NAP1 Mediates Sister Chromatid Resolution by Counteracting Protein Phosphatase 2A

    NARCIS (Netherlands)

    Y.M. Moshkin (Yuri); C.M. Doyen (Cécile); T.W. Kan (Tsung Wai); G.E. Chalkley (Gillian); K. Sap (Karen); K. Bezstarosti (Karel); J.A.A. Demmers (Jeroen); Z. Özgür (Zeliha); W.F.J. van IJcken (Wilfred); C.P. Verrijzer (Peter)

    2013-01-01

    textabstractChromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and sister chromatid resolution during mitosis. Genome-wide surveys revealed

  1. Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.

    Directory of Open Access Journals (Sweden)

    Vlad C Seitan

    2006-07-01

    Full Text Available Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating sister chromatid cohesion, but homologs of Scc4 have not hitherto been identified outside certain fungi. Some metazoan orthologs of Scc2 were initially identified as developmental gene regulators, such as Drosophila Nipped-B, a regulator of cut and Ultrabithorax, and delangin, a protein mutant in Cornelia de Lange syndrome. We show that delangin and Nipped-B bind previously unstudied human and fly orthologs of Caenorhabditis elegans MAU-2, a non-axis-specific guidance factor for migrating cells and axons. PSI-BLAST shows that Scc4 is evolutionarily related to metazoan MAU-2 sequences, with the greatest homology evident in a short N-terminal domain, and protein-protein interaction studies map the site of interaction between delangin and human MAU-2 to the N-terminal regions of both proteins. Short interfering RNA knockdown of human MAU-2 in HeLa cells resulted in precocious sister chromatid separation and in impaired loading of cohesin onto chromatin, indicating that it is functionally related to Scc4, and RNAi analyses show that MAU-2 regulates chromosome segregation in C. elegans embryos. Using antisense morpholino oligonucleotides to knock down Xenopus tropicalis delangin or MAU-2 in early embryos produced similar patterns of retarded growth and developmental defects. Our data show that sister chromatid cohesion in metazoans involves the formation of a complex similar to the Scc2-Scc4 interaction in the budding yeast. The very high degree of sequence conservation between Scc4 homologs in complex metazoans is consistent with increased selection pressure to conserve additional essential functions, such as regulation of cell and axon migration during development.

  2. Rfc5p regulates alternate RFC complex functions in sister chromatid pairing reactions in budding yeast

    OpenAIRE

    Maradeo, Marie E; Garg, Anisha; Skibbens, Robert V

    2010-01-01

    Sister chromatid pairing reactions, termed cohesion establishment, occur during S phase and appear to be regulated by replication factor C (RFC) complexes. For instance, RFCs that contain Ctf18p exhibit pro-establishment activities while those that contain Elg1p exhibit anti-establishment activities. It remains unknown whether Ctf18p-RFC and Elg1p-RFC functions are simply opposing or instead reveal complicated and non-parallel regulatory mechanisms. To better understand the nature of these no...

  3. Evaluation of the persistence in the induction of Sister Chromatid Exchanges (SCE) by alkylating agents

    International Nuclear Information System (INIS)

    Rodriguez R, R.; Huerta V, C.; MOrales R, P.R.

    2006-01-01

    The persistence in the induction of sister chromatid exchanges (SCE) by the alkylating agents methyl and ethyl-methanesulfonates (MMS and EMS) was evaluated. For it, to groups of mice its were administered a dose of these agents and later its were analyzed the induced SCE's in two periods: early and late. Both agents caused high increments of SCE in the early period and small in the late one; however, the caused lately by EMS was significantly bigger. This late induction of SCE by EMS possibly is associated with an epigenetic change or with the presence of etiladucts in the phosphodiester bonds of the DNA. (Author)

  4. The ELG1 clamp loader plays a role in sister chromatid cohesion.

    Directory of Open Access Journals (Sweden)

    Oren Parnas

    Full Text Available Mutations in the ELG1 gene of yeast lead to genomic instability, manifested in high levels of genetic recombination, chromosome loss, and gross chromosomal rearrangements. Elg1 shows similarity to the large subunit of the Replication Factor C clamp loader, and forms a RFC-like (RLC complex in conjunction with the 4 small RFC subunits. Two additional RLCs exist in yeast: in one of them the large subunit is Ctf18, and in the other, Rad24. Ctf18 has been characterized as the RLC that functions in sister chromatid cohesion. Here we present evidence that the Elg1 RLC (but not Rad24 also plays an important role in this process. A genetic screen identified the cohesin subunit Mcd1/Scc1 and its loader Scc2 as suppressors of the synthetic lethality between elg1 and ctf4. We describe genetic interactions between ELG1 and genes encoding cohesin subunits and their accessory proteins. We also show that defects in Elg1 lead to higher precocious sister chromatid separation, and that Ctf18 and Elg1 affect cohesion via a joint pathway. Finally, we localize both Ctf18 and Elg1 to chromatin and show that Elg1 plays a role in the recruitment of Ctf18. Our results suggest that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring.

  5. LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion.

    Directory of Open Access Journals (Sweden)

    Yonatan B Tzur

    Full Text Available Successful execution of the meiotic program depends on the timely establishment and removal of sister chromatid cohesion. LAB-1 has been proposed to act in the latter by preventing the premature removal of the meiosis-specific cohesin REC-8 at metaphase I in C. elegans, yet the mechanism and scope of LAB-1 function remained unknown. Here we identify an unexpected earlier role for LAB-1 in promoting the establishment of sister chromatid cohesion in prophase I. LAB-1 and REC-8 are both required for the chromosomal association of the cohesin complex subunit SMC-3. Depletion of lab-1 results in partial loss of sister chromatid cohesion in rec-8 and coh-4 coh-3 mutants and further enhanced chromatid dissociation in worms where all three kleisins are mutated. Moreover, lab-1 depletion results in increased Aurora B kinase (AIR-2 signals in early prophase I nuclei, coupled with a parallel decrease in signals for the PP1 homolog, GSP-2. Finally, LAB-1 directly interacts with GSP-1 and GSP-2. We propose that LAB-1 targets the PP1 homologs to the chromatin at the onset of meiosis I, thereby antagonizing AIR-2 and cooperating with the cohesin complex to promote sister chromatid association and normal progression of the meiotic program.

  6. UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells

    DEFF Research Database (Denmark)

    Oka, Yasuyoshi; Varmark, Hanne; Vitting-Seerup, Kristoffer

    2014-01-01

    , leading to globally enhanced intron retention. Defective sister chromatid cohesion is a general consequence of dysfunctional pre-mRNA splicing, resulting from the selective downregulation of the cohesion protection factor Sororin. As the UBL5 yeast orthologue, Hub1, also promotes spliceosome functions...

  7. Sister-chromatid exchange analysis in a rural population of Mexico exposed to pesticides.

    Science.gov (United States)

    Gómez-Arroyo, S; Noriega-Aldana, N; Osorio, A; Galicia, F; Ling, S; Villalobos-Pietrini, R

    1992-03-01

    Cytogenetic damage was evaluated by means of the analysis of sister-chromatid exchange (SCE) in a rural population of Tlaxcala, Mexico, in occupational contact with pesticides. We studied 170 men, 94 exposed and 76 not exposed. It was shown that SCE followed a normal distribution and Student's t test did not present differences between the two groups (P = 0.4). The frequency of SCE was not correlated with the duration of exposure of the rural workers (r = -0.06), the multiple covariance analysis applied to the data of duration of exposure, tobacco intake and alcohol ingestion demonstrated a lack of statistical significance. In the exposed people we observed no symptoms provoked by these compounds.

  8. Elevated sister chromatid exchange frequencies in New Zealand Vietnam War veterans.

    Science.gov (United States)

    Rowland, R E; Edwards, L A; Podd, J V

    2007-01-01

    From July 1965 until November 1971, New Zealand Defence Force Personnel fought in the Vietnam War. During this time more than 76,500,000 litres of phenoxylic herbicides were sprayed over parts of Southern Vietnam and Laos, the most common being known as 'Agent Orange'. The current study aimed to ascertain whether or not New Zealand Vietnam War veterans show evidence of genetic disturbance arising as a consequence of their now confirmed exposure to these defoliants. A sample group of 24 New Zealand Vietnam War veterans and 23 control volunteers were compared using an SCE (sister chromatid exchange) analysis. The results from the SCE study show a highly significant difference (P Vietnam War veterans studied here were exposed to a clastogenic substance(s) which continues to exert an observable genetic effect today, and suggest that this is attributable to their service in Vietnam. Copyright 2007 S. Karger AG, Basel.

  9. In vivo sister-chromatid exchange: a sensitive measure of DNA damage

    International Nuclear Information System (INIS)

    Nakanishi, Y.; Schneider, E.L.

    1979-01-01

    A variety of chemical agents of X-irradiation were examined for their abilities to induce sister-chromatid exchanges (SCE) in vivo. In addition to demonstrating that several known mutagens and carcinogens are capable of inducing SCE in vivo, the studies indicate that the suspected carcinogen, tris-bromophosphate, can significantly elevate SCE levels. Comparison of the effects of these agents on SCE levels, chromosomal-aberration frequencies and cell-replication kinetics reveals that no consistent relationship exists between SCE levels and other indicators of cellular DNA damage. It is proposed that analysis of SCE induction in vivo may provide a useful technique for the screening of mutagenic and carcinogenic compounds. (Auth.)

  10. The Elg1-RFC clamp-loading complex performs a role in sister chromatid cohesion.

    Science.gov (United States)

    Maradeo, Marie E; Skibbens, Robert V

    2009-01-01

    It is widely accepted that of the four Replication Factor C (RFC) complexes (defined by the associations of either Rfc1p, Ctf18p, Elg1p or Rad24p with Rfc2p-Rfc5p), only Ctf18-RFC functions in sister chromatid cohesion. This model is based on findings that CTF18 deletion is lethal in combination with mutations in either CTF7(ECO1) or MCD1 sister chromatid cohesion genes and that ctf18 mutant cells exhibit cohesion defects. Here, we report that Elg1-RFC not only participates in cohesion but performs a function that is distinct from that of Ctf18-RFC. The results show that deletion of ELG1 rescues both ctf7(eco1) mutant cell temperature sensitivity and cohesion defects. Moreover, over-expression of ELG1 enhances ctf7(eco1) mutant cell phenotypes. These findings suggest that the balance of Ctf7p(Eco1p) activity depends on both Ctf18-RFC and Elg1-RFC. We also report that ELG1 deletion produces cohesion defects and intensifies the conditional phenotype of mcd1 mutant cells, further supporting a role for Elg1-RFC in cohesion. Attesting to the specificity of these interactions, deletion of RAD24 neither suppressed nor exacerbated cohesion defects in either ctf7(eco1) or mcd1 mutant cells. While parallel analyses failed to uncover a similar role in cohesion for Rad24-RFC, it is well known that Rad24-RFC, Elg1-RFC and Ctf18-RFC play key roles in DNA damage responses. We tested and found that Ctf7p(Eco1p) plays a significant role in Rad24-RFC-based DNA response pathways. In combination, these findings challenge current views and document new and distinct roles for RFC complexes in cohesion and for Ctf7p(Eco1p) in DNA repair.

  11. The Elg1-RFC clamp-loading complex performs a role in sister chromatid cohesion.

    Directory of Open Access Journals (Sweden)

    Marie E Maradeo

    Full Text Available It is widely accepted that of the four Replication Factor C (RFC complexes (defined by the associations of either Rfc1p, Ctf18p, Elg1p or Rad24p with Rfc2p-Rfc5p, only Ctf18-RFC functions in sister chromatid cohesion. This model is based on findings that CTF18 deletion is lethal in combination with mutations in either CTF7(ECO1 or MCD1 sister chromatid cohesion genes and that ctf18 mutant cells exhibit cohesion defects. Here, we report that Elg1-RFC not only participates in cohesion but performs a function that is distinct from that of Ctf18-RFC. The results show that deletion of ELG1 rescues both ctf7(eco1 mutant cell temperature sensitivity and cohesion defects. Moreover, over-expression of ELG1 enhances ctf7(eco1 mutant cell phenotypes. These findings suggest that the balance of Ctf7p(Eco1p activity depends on both Ctf18-RFC and Elg1-RFC. We also report that ELG1 deletion produces cohesion defects and intensifies the conditional phenotype of mcd1 mutant cells, further supporting a role for Elg1-RFC in cohesion. Attesting to the specificity of these interactions, deletion of RAD24 neither suppressed nor exacerbated cohesion defects in either ctf7(eco1 or mcd1 mutant cells. While parallel analyses failed to uncover a similar role in cohesion for Rad24-RFC, it is well known that Rad24-RFC, Elg1-RFC and Ctf18-RFC play key roles in DNA damage responses. We tested and found that Ctf7p(Eco1p plays a significant role in Rad24-RFC-based DNA response pathways. In combination, these findings challenge current views and document new and distinct roles for RFC complexes in cohesion and for Ctf7p(Eco1p in DNA repair.

  12. Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis.

    Directory of Open Access Journals (Sweden)

    Tamara Goldfarb

    2010-10-01

    Full Text Available Recombination between homologous chromosomes of different parental origin (homologs is necessary for their accurate segregation during meiosis. It has been suggested that meiotic inter-homolog recombination is promoted by a barrier to inter-sister-chromatid recombination, imposed by meiosis-specific components of the chromosome axis. Consistent with this, measures of Holliday junction-containing recombination intermediates (joint molecules [JMs] show a strong bias towards inter-homolog and against inter-sister JMs. However, recombination between sister chromatids also has an important role in meiosis. The genomes of diploid organisms in natural populations are highly polymorphic for insertions and deletions, and meiotic double-strand breaks (DSBs that form within such polymorphic regions must be repaired by inter-sister recombination. Efforts to study inter-sister recombination during meiosis, in particular to determine recombination frequencies and mechanisms, have been constrained by the inability to monitor the products of inter-sister recombination. We present here molecular-level studies of inter-sister recombination during budding yeast meiosis. We examined events initiated by DSBs in regions that lack corresponding sequences on the homolog, and show that these DSBs are efficiently repaired by inter-sister recombination. This occurs with the same timing as inter-homolog recombination, but with reduced (2- to 3-fold yields of JMs. Loss of the meiotic-chromosome-axis-associated kinase Mek1 accelerates inter-sister DSB repair and markedly increases inter-sister JM frequencies. Furthermore, inter-sister JMs formed in mek1Δ mutants are preferentially lost, while inter-homolog JMs are maintained. These findings indicate that inter-sister recombination occurs frequently during budding yeast meiosis, with the possibility that up to one-third of all recombination events occur between sister chromatids. We suggest that a Mek1-dependent reduction in

  13. Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells

    International Nuclear Information System (INIS)

    Sajesh, Babu V; Lichtensztejn, Zelda; McManus, Kirk J

    2013-01-01

    Chromosome instability manifests as an abnormal chromosome complement and is a pathogenic event in cancer. Although a correlation between abnormal chromosome numbers and cancer exist, the underlying mechanisms that cause chromosome instability are poorly understood. Recent data suggests that aberrant sister chromatid cohesion causes chromosome instability and thus contributes to the development of cancer. Cohesion normally functions by tethering nascently synthesized chromatids together to prevent premature segregation and thus chromosome instability. Although the prevalence of aberrant cohesion has been reported for some solid tumors, its prevalence within liquid tumors is unknown. Consequently, the current study was undertaken to evaluate aberrant cohesion within Hodgkin lymphoma, a lymphoid malignancy that frequently exhibits chromosome instability. Using established cytogenetic techniques, the prevalence of chromosome instability and aberrant cohesion was examined within mitotic spreads generated from five commonly employed Hodgkin lymphoma cell lines (L-1236, KM-H2, L-428, L-540 and HDLM-2) and a lymphocyte control. Indirect immunofluorescence and Western blot analyses were performed to evaluate the localization and expression of six critical proteins involved in the regulation of sister chromatid cohesion. We first confirmed that all five Hodgkin lymphoma cell lines exhibited chromosome instability relative to the lymphocyte control. We then determined that each Hodgkin lymphoma cell line exhibited cohesion defects that were subsequently classified into mild, moderate or severe categories. Surprisingly, ~50% of the mitotic spreads generated from L-540 and HDLM-2 harbored cohesion defects. To gain mechanistic insight into the underlying cause of the aberrant cohesion we examined the localization and expression of six critical proteins involved in cohesion. Although all proteins produced the expected nuclear localization pattern, striking differences in RAD21

  14. Influence of irradiation at different stages of mitotic cycle upon production of sister chromatid exchanges in cultured Chinese hamster cells

    International Nuclear Information System (INIS)

    Antoshina, M.M.; Poryadkova, N.A.; Luchnik, N.V.

    1982-01-01

    Frequency of sister chromatid exchanges (SCE) and microexchanges in Chinese hamster cells has been studied by means of the method of differential staining of chromatids on irradiation at different stages of the mitotic cycle. It is shown that the irradiation enhances frequency of SCE and microexchanges if it is carried out before the end of DNA replication synthesis. Comparison of frequency depenedence of radiation-induced microexchanges and SCE at different stages of the mitotic cycle results in the conclusion that the microexchanges are none other than small SCE

  15. Premature Sister Chromatid Separation Is Poorly Detected by the Spindle Assembly Checkpoint as a Result of System-Level Feedback

    Directory of Open Access Journals (Sweden)

    Mihailo Mirkovic

    2015-10-01

    Full Text Available Sister chromatid cohesion, mediated by the cohesin complex, is essential for faithful mitosis. Nevertheless, evidence suggests that the surveillance mechanism that governs mitotic fidelity, the spindle assembly checkpoint (SAC, is not robust enough to halt cell division when cohesion loss occurs prematurely. The mechanism behind this poor response is not properly understood. Using developing Drosophila brains, we show that full sister chromatid separation elicits a weak checkpoint response resulting in abnormal mitotic exit after a short delay. Quantitative live-cell imaging approaches combined with mathematical modeling indicate that weak SAC activation upon cohesion loss is caused by weak signal generation. This is further attenuated by several feedback loops in the mitotic signaling network. We propose that multiple feedback loops involving cyclin-dependent kinase 1 (Cdk1 gradually impair error-correction efficiency and accelerate mitotic exit upon premature loss of cohesion. Our findings explain how cohesion defects may escape SAC surveillance.

  16. Ultraviolet-induced formation of micronuclei and sister chromatid exchange in cultured fibroblasts of patients with cutaneous malignant melanoma

    International Nuclear Information System (INIS)

    Roser, M.; Boehm, A.O.; Oldigs, M.; Weichenthal, M.; Reimers, U.; Schmidt-Preuss, U.; Breitbart, E.W.; Ruediger, H.W.

    1989-01-01

    Genetically enhanced sensitivity to ultraviolet (UV) radiation may play an important role in the development of cutaneous malignant melanoma (CMM). This was studied in cultured fibroblasts of 26 CMM patients and controls by micronucleus (MN) test and sister chromatid exchange (SCE) after UV irradiation (375 J/m2). Sister chromatid exchange and MN formation were used as parameters to detect the UV-induced genotoxic damage in the individual cell strains. We found that the UV-induced level of MN was significantly increased in CMM patients (p = 0.0005), being most pronounced in the familial cases (p = 0.0001). Ultraviolet-induced SCE was also elevated in CMM patients (p = 0.001), but there was no difference between familial and nonfamilial cases. The present findings indicate that genetic predisposition contributes to the development of CMM in a subset of CMM patients and may be due to an enhanced susceptibility to UV light

  17. Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.

    Science.gov (United States)

    Mayer, M L; Gygi, S P; Aebersold, R; Hieter, P

    2001-05-01

    We have identified and characterized an alternative RFC complex RFC(Ctf18p, Ctf8p, Dcc1p) that is required for sister chromatid cohesion and faithful chromosome transmission. Ctf18p, Ctf8p, and Dcc1p interact physically in a complex with Rfc2p, Rfc3p, Rfc4p, and Rfc5p but not with Rfc1p or Rad24p. Deletion of CTF18, CTF8, or DCC1 singly or in combination (ctf18Deltactf8Deltadcc1Delta) leads to sensitivity to microtubule depolymerizing drugs and a severe sister chromatid cohesion defect. Furthermore, temperature-sensitive mutations in RFC4 result in precocious sister chromatid separation. Our results highlight a novel function of the RFC proteins and support a model in which sister chromatid cohesion is established at the replication fork via a polymerase switching mechanism and a replication-coupled remodeling of chromatin.

  18. A study of sister chromatid exchange in patients with dental amalgam restorations.

    Science.gov (United States)

    Priya, E Lakshmi; Ranganathan, K; Rao, Uma Devi K; Joshua, Elizabeth; Mathew, Deepu George; Wilson, Kavitha

    2014-01-01

    Dental amalgam is still widely used as a restorative material in developing countries due to its low cost and ease of manipulation. The health risks associated with the components of this restorative material has always been a matter of concern. Our study was designed to address this question regarding dental amalgam. To study sister chromatid exchange (SCE) as an indicator of systemic genotoxicity, due to the exposure from the components of amalgam restorations during its placement and chronic use. Systemic genotoxicity in subjects exposed to amalgam during its placement (Group II; n=5) and subjects with chronic exposure to amalgam (Group III; n=5) were compared with controls (Group I; n=5) by SCE assay in cultured peripheral blood lymphocytes. Subjects exposed to amalgam during its placement and subjects having chronic exposure to amalgam showed an increase in the frequency of SCE, but the change was not statistically significant (P=0.84, P=0.123 respectively). Systemic genotoxicity was not observed due to the components of amalgam restorations released during its placement and chronic use. The findings of this study can be considered as preliminary information on the systemic toxicity due to the components of amalgam restorations.

  19. Role of oxygen free radicals in the induction of sister chromatid exchanges by cigarette smoke

    International Nuclear Information System (INIS)

    Lee, C.K.; Brown, B.G.; Rice, W.Y. Jr.; Doolittle, D.J.

    1989-01-01

    Cigarette smoke has been reported to contain free radicals and free radical generators in both the gas and particulate phases. Studies in our laboratory have shown that both cigarette smoke condensate (CSC) and smoke bubbled through phosphate buffered saline solution (smoke-PBS) increased sister chromatid exchanges (SCE) in Chinese hamster ovary cells in a dose-dependent manner. Since oxygen free radicals have been shown to cause SCEs and other chromosomal damage, we investigated the role of these radicals in the induction of SCEs by CSC and smoke-PBS. Addition of the antioxidant enzymes catalase and superoxide dismutase or the oxygen-radical scavenger ascorbic acid failed to reduce the SCE frequency in the presence of either CSC or smoke-PBS. Additional studies indicated that the quantity of hydrogen peroxide produced in CSC or smoke-PBS is too small to account for the observed SCE induction. It appears, therefore, that SCE induction by CSC or smoke-PBS does not involve the participation of oxygen free radicals

  20. Enhanced response to the induction of sister chromatid exchange by gamma radiation in neurofibromatosis

    International Nuclear Information System (INIS)

    Hafez, M.; Abd el-Nabi, S.M.; el-Wehedi, G.; Al-Tonbary, Y.

    1986-01-01

    The study included 8 unrelated patients with neurofibromatosis, and 10 unrelated normal and healthy persons as controls. Whole blood samples were divided into plastic T flasks and exposed at room temperature to gamma rays. The radiation dose was 36 rad/minute, and the doses delivered were 0, 75, 150 and 300 rad. The lymphocytes were cultured in (RPMI) 1640 tissue culture medium and autologous serum (20%). Phytohemagglutinin and bromodeoxyuridine (Brdu) (10 microM) were added at initiation of culture and harvesting was done 64 to 68 hours after culture initiation. Slides were coded, differential staining was done, and sister chromatid exchanges (SCEs) and aberrations (gaps, breaks, dicentrics, fragments and minutes) were counted. In the controls no significant increase in frequency of SCE has been found (P greater than 0.5). In the patients, the frequencies significantly increased with the increase of dose of irradiation (P less than 0.001). Furthermore, after irradiation, the incidence of gaps, breaks, and dicentrics were significantly increased in patients compared with controls. Moreover, the incidence increased with the increase in the dose of radiation. The results are discussed with a conclusion that the results add to the indication of a genetic predisposition to develop cancer in neurofibromatosis patients

  1. Acute wood or coal exposure with carbon monoxide intoxication induces sister chromatid exchange

    Energy Technology Data Exchange (ETDEWEB)

    Ozturk, S.; Vatansever, S.; Cefle, K.; Palanduz, S.; Guler, K.; Erten, N.; Erk, O.; Karan, M.A.; Tascioglu, C. [University of Istanbul, Istanbul (Turkey). Istanbul Faculty of Medicine

    2002-07-01

    The object of this study was to investigate the genotoxic effect of acute overexposure to combustion products originating from coal or wood stoves in patients presenting with acute carbon monoxide intoxication. The authors analyzed the frequency of sister chromatid exchange and the carboxyhemoglobin concentration in 20 consecutive patients without a history of smoking or drug use who had been treated in the Emergency Care Unit of Istanbul Medical Faculty due to acute carbon monoxide intoxication. All of these cases were domestic accidents due to dysfunctioning coal or wood stoves. The results were compared with a control group of 20 nonsmoking, nondrug-using healthy individuals matched for age, sex, and absence of other chemical exposure. It was concluded that acute exposure to combustion products of wood or coal is genotoxic to DNA. Potential causes of genotoxicity include known mutagenic compounds present in coal or wood smoke and ash, oxygen radicals formed during combustion, as well as hypoxic and reperfusion injury mechanisms initiated by carbon monoxide intoxication.

  2. Rfc5p regulates alternate RFC complex functions in sister chromatid pairing reactions in budding yeast.

    Science.gov (United States)

    Maradeo, Marie E; Garg, Anisha; Skibbens, Robert V

    2010-11-01

    Sister chromatid pairing reactions, termed cohesion establishment, occur during S-phase and appear to be regulated by Replication Factor C (RFC) complexes. For instance, RFCs that contain Ctf18p exhibit pro-establishment activities while those that contain Elg1p exhibit anti-establishment activities. It remains unknown whether Ctf18p-RFC and Elg1p-RFC functions are simply opposing or instead reveal complicated and non-parallel regulatory mechanisms. To better understand the nature of these novel pathways, we analyzed the small RFC subunit Rfc5p that is common to both Ctf18p-RFC and Elg1p-RFC. Despite this commonality, the data show that diminished Rfc5p function rescues ctf7/eco1 mutant cell phenotypes, revealing that Rfc5p promotes anti-establishment activities. This rescue is specific to establishment pathways in that rfc5-1 greatly accentuates growth defects when expressed in scc2 (deposition), mcd1/scc1 or smc3 (cohesion maintenance) mutated cells. Our results reveal for the first time a role for small RFC subunits in directing RFC complex functions-in this case towards anti-establishment pathways. We further report that Pds5p exhibits both establishment and anti-establishment functions in cohesion. This duality suggests that categorizations of establishment and anti-establishment activities require further examination.

  3. Chromosome aberration and sister chromatid exchange test results with 42 chemicals.

    Science.gov (United States)

    Anderson, B E; Zeiger, E; Shelby, M D; Resnick, M A; Gulati, D K; Ivett, J L; Loveday, K S

    1990-01-01

    Forty-two chemicals were tested for their ability to induce cytogenetic change in Chinese hamster ovary cells using assays for chromosome aberrations (ABS) and sister chromatid exchanges (SCE). These chemicals were included in the National Toxicology Program's evaluation of the ability of four in vitro short-term genetic toxicity assays to distinguish between rodent carcinogens and noncarcinogens. The conclusions of this comparison are presented in Zeiger et al. [Zeiger E, Haseman JK, Shelby MD, Margolin BH, Tennant RW (1990): [Environ Molec Mutagen 16(Suppl 18): 1-14]. The in vitro cytogenetic testing was conducted at four laboratories, each using a standard protocol to evaluate coded chemicals with and without exogenous metabolic activation. Most chemicals were tested in a single laboratory; however, two chemicals, tribromomethane and p-chloroaniline, were tested at two laboratories as part of an interlaboratory comparison. Four chemicals (C.I. basic red 9 HCl, 2-mercaptobenzothiazole, oxytetracycline HCl, and rotenone) were tested for SCE in one laboratory and in a different laboratory for ABS. Tetrakis(hydroxymethyl)phosphonium sulfate was tested at one laboratory and the chloride form was tested at a different laboratory. Twenty-five of the 42 chemicals tested induced SCE. Sixteen of these also induced ABS; all chemicals that induced ABS also induced SCE. There was approximately 79% reproducibility of results in repeat tests, thus, we conclude that this protocol is effective and reproducible in detecting ABS and SCE.

  4. Frequency of sister chromatid exchanges in lymphocyte cultures of human peripheral blood after the combined effect of γ-radiation and caffeine

    International Nuclear Information System (INIS)

    Nugis, V.Yu.; Pyatkin, E.K.

    1986-01-01

    Keeping of human peripheral blood lymphocytes, irradiated in vitro with 60 Co-γ-quanta at a dose of 3 Gy at G 0 phase, with caffeine of 16 and 160 μg/ml during cultivation with PHA had no appreciable influence on the fraquency of sister chromatid exchanges. A minor increase in the number of sister chromatid exchanges was only noted when nonirradiated and irradiated lymphocytes were cultured with 160 μg/ml caffeine

  5. Health assessment of gasoline and fuel oxygenate vapors: micronucleus and sister chromatid exchange evaluations.

    Science.gov (United States)

    Schreiner, Ceinwen A; Hoffman, Gary M; Gudi, Ramadevi; Clark, Charles R

    2014-11-01

    Micronucleus and sister chromatid exchange (SCE) tests were performed for vapor condensate of baseline gasoline (BGVC), or gasoline with oxygenates, methyl tert-butyl ether (G/MTBE), ethyl tert butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), t-butyl alcohol (TBA), or ethanol (G/EtOH). Sprague Dawley rats (the same 5/sex/group for both endpoints) were exposed to 0, 2000, 10,000, or 20,000mg/m(3) of each condensate, 6h/day, 5days/week over 4weeks. Positive controls (5/sex/test) were given cyclophosphamide IP, 24h prior to sacrifice at 5mg/kg (SCE test) and 40mg/kg (micronucleus test). Blood was collected from the abdominal aorta for the SCE test and femurs removed for the micronucleus test. Blood cell cultures were treated with 5μg/ml bromodeoxyuridine (BrdU) for SCE evaluation. No significant increases in micronucleated immature erythrocytes were observed for any test material. Statistically significant increases in SCE were observed in rats given BGVC alone or in female rats given G/MTBE. G/TAME induced increased SCE in both sexes at the highest dose only. Although DNA perturbation was observed for several samples, DNA damage was not expressed as increased micronuclei in bone marrow cells. Inclusion of oxygenates in gasoline did not increase the effects of gasoline alone or produce a cytogenetic hazard. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. The Relationship between Dioxin Congeners in the Breast Milk of Vietnamese Women and Sister Chromatid Exchange

    Directory of Open Access Journals (Sweden)

    Hiroyuki Suzuki

    2014-04-01

    Full Text Available The aim of this study was to clarify the relationship between dioxin concentrations in breast milk and the sister chromatid exchange (SCE frequency in women from herbicide-sprayed and non sprayed areas. Blood samples were taken from 21 women with high TCDD (tetrachlorodibenzo-p-dioxin levels from sprayed areas, 23 women with moderate TCDD levels from sprayed areas, and 19 women from non sprayed areas to determine their SCE frequency. The SCE frequencies for the high and moderate TCDD groups from the sprayed area and for the non sprayed area group were 2.40, 2.19, and 1.48 per cell, respectively. Multiple regression analysis showed that the standardized β values for 1,2,3,6,7,8-hexaCDD (β = 0.60, 1,2,3,4,6,7,8-heptaCDD (β = 0.64, and octaCDD (β = 0.65 were higher than those for TCDD (β = 0.34 and 1,2,3,7,8-pentaCDD (β = 0.42. The adjusted R2 value for polyCDDs (R2 = 0.38 was higher than that for polyCDD toxic equivalents (TEQ (toxic equivalents; R2 = 0.23. This study therefore shows that levels of hexa-, hepta-, and octaCDD, which were previously regarded as being less toxic than TCDD, are closely related to SCE frequency and that the level of dioxin (pg/g lipid is potentially more useful as an indicator than TEQ value for explaining SCE frequency.

  7. Chiasmata promote monopolar attachment of sister chromatids and their co-segregation toward the proper pole during meiosis I.

    Directory of Open Access Journals (Sweden)

    Yukinobu Hirose

    2011-03-01

    Full Text Available The chiasma is a structure that forms between a pair of homologous chromosomes by crossover recombination and physically links the homologous chromosomes during meiosis. Chiasmata are essential for the attachment of the homologous chromosomes to opposite spindle poles (bipolar attachment and their subsequent segregation to the opposite poles during meiosis I. However, the overall function of chiasmata during meiosis is not fully understood. Here, we show that chiasmata also play a crucial role in the attachment of sister chromatids to the same spindle pole and in their co-segregation during meiosis I in fission yeast. Analysis of cells lacking chiasmata and the cohesin protector Sgo1 showed that loss of chiasmata causes frequent bipolar attachment of sister chromatids during anaphase. Furthermore, high time-resolution analysis of centromere dynamics in various types of chiasmate and achiasmate cells, including those lacking the DNA replication checkpoint factor Mrc1 or the meiotic centromere protein Moa1, showed the following three outcomes: (i during the pre-anaphase stage, the bipolar attachment of sister chromatids occurs irrespective of chiasma formation; (ii the chiasma contributes to the elimination of the pre-anaphase bipolar attachment; and (iii when the bipolar attachment remains during anaphase, the chiasmata generate a bias toward the proper pole during poleward chromosome pulling that results in appropriate chromosome segregation. Based on these results, we propose that chiasmata play a pivotal role in the selection of proper attachments and provide a backup mechanism that promotes correct chromosome segregation when improper attachments remain during anaphase I.

  8. What are sister chromatid exchanges. [Applications of SCE test in investigations of properties of carcinogens and mutagens

    Energy Technology Data Exchange (ETDEWEB)

    Galloway, S. M.

    1977-05-01

    Methods for detecting sister chromatid exchanges (SCEs) and some applications of the SCE test in investigations of the properties of carcinogens and mutagens are discussed. The relations of SCEs to chromosome aberration formation, DNA repair processes, and mutation were studied. It was concluded that SCEs are not simply related to chromosome aberrations or to any one known repair mechanism. They may involve a recombination event, often instituted at the replication fork, but also provoked by any unrepaired damage in the replicated DNA. The molecular mechanism of SCE is unknown and the investigation of the relationship of SCE to mutation is only beginning to yield information.

  9. In vivo study on the replicative model validity of sister chromatid exchanges production

    International Nuclear Information System (INIS)

    Cruz V, V.L.

    1996-01-01

    The sister chromatid exchanges (SCE) frequency determination has been used as index of damage to DNA, however the biological meaning of this event is still ignored. Different models in order to explain the mechanism of their formation have been proposed and they could be contained in two categories: a) those that consider that the SCE is produced by means of discreet lesions to the DNA and that they occur in the place of the lesion, and b) those that propose that the SCE is caused by a group of lesions and that therefore the place in which they occur could not be associated with a lesion in particular. The model of Painter (1980) belongs to this last group. It suggests that the region of the DNA where the clusters are united, is the only place in which the exchange of double chain could happen during the synthesis of the DNA and makes the prediction that since the x rays retard the beginning of the duplication, the pretreatment with ionizing radiation would reduce the frequency of SCE induced by agents capable to block the lengthening of the chain of DNA, that are the most efficient SCE inducers. The objective of the present work was to establish the validity of this replicative model for the SCE formation, based in its prediction. The effect of the unilateral preexposition of mouse to gamma radiation was determined on the SCE induction by Mitomycin C (MMC), in cells of the femoral bone marrow In vivo. This strategy allows to determine the effect of the pretreatment in the same organism, minimizing the variability of the response between individuals. There was not a significant variability between the frequencies of SCE, basal and induced by gamma radiation or MMC in the same organism. The animals that received the gamma radiation pretreatment, showed a reduction of approximately the 30 % in the frequency of SCE, assuming an additive effect of the radiation with the MMC. These results coincide with the prediction of the model of Painter, however it is not

  10. Possible mechanisms of chromosomal aberrations: VII. Comparative dynamics of sister chromatid disjunction and realization of radiation-induced chromosomal aberrations during mitosis

    International Nuclear Information System (INIS)

    Lebedeva, L.I.; Akhmamet'eva, E.M.

    1994-01-01

    An increase in radiation-induced chromosomal aberrations during c-metaphase sister chromatid disjunction was demonstrated in murine bone marrow cells exposed to a total γ-irradiation at 0.5 Gy. Caffeine (Cf) treatment during mitosis partially suppressed the chromatid disjunction rate and increased the number of radiation-induced aberrations in this mitosis. Nalidixic acid (NA) treatment of c-metaphase cells completely suppressed chromatid disjunction and the realization of induced aberrations. Topoisomerase 2 was assumed to be involved during mitosis in both processes

  11. The Scc2/Scc4 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions

    Science.gov (United States)

    Lopez-Serra, Lidia; Kelly, Gavin; Patel, Harshil; Stewart, Aengus; Uhlmann, Frank

    2014-01-01

    The cohesin complex is at the heart of many chromosomal activities, including sister chromatid cohesion and transcriptional regulation1-3. Cohesin loading onto chromosomes depends on the Scc2/Scc4 cohesin loader complex4-6, but the chromatin features that form cohesin loading sites remain poorly understood. Here, we show that the RSC chromatin remodeling complex recruits budding yeast Scc2/Scc4 to broad nucleosome-free regions, that the cohesin loader itself helps to maintain. Consequently, inactivation of the cohesin loader or RSC complex have similar effects on nucleosome positioning, gene expression and sister chromatid cohesion. These results reveal an intimate link between local chromatin structure and higher order chromosome architecture. Our findings pertain to the similarities between two severe human disorders, Cornelia de Lange syndrome, caused by mutations in the human cohesin loader, and Coffin-Siris syndrome, resulting from mutations in human RSC complex components7-9. Both could arise from gene misregulation due to related changes in the nucleosome landscape. PMID:25173104

  12. Effects of radiation on frequency of chromosomal aberrations and sister chromatid exchange in the benthic worm Neanthes arenaceodentata

    International Nuclear Information System (INIS)

    Harrison, F.L.; Rice, D.W. Jr.; Moore, D.H.; Varela, M.

    1983-04-01

    Traditional bioassays are unsuitable for assessing sublethal effects of low levels of radioactivity because mortality and phenotypic responses are not anticipated. We compared the usefulness of chromosomal aberration (CA) and sister chromatid exchange (SCE) induction as measures of low-level radiation effects in a sediment-dwelling marine worm, Neanthes arenaceodentata. Newly hatched larvae were exposed to two radiation exposure regimes. Groups of 100 larvae were exposed to either x rays delivered at high dose rates (0.7 Gy min -1 ) or to 60 Co gamma rays delivered at low dose rates (4.8 X 10 -5 to 1.2 X 10 -1 Gy h -1 ). After irradiation, the larvae were exposed to 3 X 10 -5 M bromodeoxyuridine (BrdUrd) for 28 h (x-ray-irradiated larvae) or for 54 h ( 60 Co-irradiated larvae). Slides of larval cells were prepared for observation of CAs and SCEs. Frequencies of CAs were determined in first division cells; frequencies of SCEs were determined in second division cells. Results from x-ray irradiation indicated that dose-related increases occur in chromosome and chromatid deletions, but an x-ray dose greater than or equal to 2 Gy was required to observe a significant increase. Worm larvae receiving 60 Co irradiation showed elevated SCE frequencies; a significant increase in SCE frequency was observed at 0.6 Gy. 49 references, 2 figures

  13. Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fision yeast to humans.

    NARCIS (Netherlands)

    S. Parisi; M.J. McKay (Michael); M. Molnar; M.A. Thompson (Anne); P.J. van der Spek (Peter); E. van Drunen-Schoenmaker; R. Kanaar (Roland); E. Lehmann; J.H.J. Hoeijmakers (Jan); J. Kohli

    1999-01-01

    textabstractOur work and that of others defined mitosis-specific (Rad21 subfamily) and meiosis-specific (Rec8 subfamily) proteins involved in sister chromatid cohesion in several eukaryotes, including humans. Mutation of the fission yeast Schizosaccharomyces pombe rec8 gene was previously shown to

  14. Induction of sister-chromatid exchanges in ICR 2A frog cells exposed to 254 nm UV wavelengths

    International Nuclear Information System (INIS)

    Chao, C.C.K.; Rosenstein, B.S.

    1985-01-01

    Exposure of ICR 2A frog cells to 254 nm UV induced the formation of sister-chromatid exchanges (SCEs) in a fluence-dependent manner. Cells were also exposed to the UV produced by a fluorescent sunlamp that was filtered through 8C Mylar in order to simulate the mid-UV (290-320 nm) portion of sunlight reaching the earth's surface. In this instance, SCEs were induced in a linear fashion at low fluences but reached a plateau at a low level of induced SCEs. In addition, pretreatment of cells with the solar UV followed by exposure to 254 nm UV resulted in a significantly lower level of SCEs than in cells exposed to 254 nm UV alone. (author)

  15. X-ray induced sister chromatid exchange and chromosomal aberrations in the lymphocytes from the patients with neurofibromatosis

    International Nuclear Information System (INIS)

    Hoshino, Hitoshi; Takeshita, Tatsuya; Iijima, Sumio; Asaka, Akio; Segawa, Masaya; Higurashi, Makoto.

    1990-01-01

    Neurofibromatosis (NF), an autosomal dominant disease, is diagnosed by the presence of more than 6 Cafe-au-lait spots and neurofibromas in late childhood or adolescence. We examined the frequencies of sister chromatid exchange (SCE) and chromosomal aberrations (dicentrics and rings) in cultured lymphocytes from patients with NF and normal controls after X-ray irradiation at doses of 2.5, 5.0 and 7.5 Gy. No differences in the baseline SCE frequencies were found between the NF patients and controls. The frequency of SCE increased with the irradiation dose in both patients and controls with no apparent differences between the two groups. In addition, the frequencies of spontaneous and X-ray induced chromosomal aberrations in the patients were not significantly different from those in the controls. The presence of genetic heterogeneity causing NF was suggested. (author)

  16. Sister chromatid exchanges in X-ray irradiated blood lymphocytes from patients with hereditary diseases with radioresistant DNA synthesis

    International Nuclear Information System (INIS)

    Pleskach, N.M.; Andriadze, M.I.; Mikhel'son, V.M.; Zhestyanikov, V.D.

    1988-01-01

    X-ray irradiation induced sister chromatid exchanges (SCE) in blood lymphocytes from patient with Down's syndrome and adult progeria (in both the cases radioresistant DNA synthesis takes place). In normal lymphocytes (in which ionizing radiation inhibits the replicative synthesis of DNA) the rate of SCE rises with the rise of radiation dose. Thus, the rate of SCE in X-ray irradiated lymphocytes is in reverse dependence with radioresistance of replicative synthesis of DNA. The data obtained are explained in accordance with the replicative hypothesis of the SCE nature (Painter, 1980a): in cells of patients with Down's syndrome, xeroderma pigmentosum from 2 and progeria of adults the time of existence of partly replicated clusters of replicons is decreased due to radioresistant replicative synthesis of DNA, but the presence of partly replicated clusters of replicons in necessary for SCE formation. Therefore the rate of SCF in X-irradiated cells of these patients decreases

  17. SGO1 maintains bovine meiotic and mitotic centromeric cohesions of sister chromatids and directly affects embryo development.

    Directory of Open Access Journals (Sweden)

    Feng-Xia Yin

    Full Text Available Shugoshin (SGO is a critical factor that enforces cohesion from segregation of paired sister chromatids during mitosis and meiosis. It has been studied mainly in invertebrates. Knowledge of SGO(s in a mammalian system has only been reported in the mouse and Hela cells. In this study, the functions of SGO1 in bovine oocytes during meiotic maturation, early embryonic development and somatic cell mitosis were investigated. The results showed that SGO1 was expressed from germinal vesicle (GV to the metaphase II stage. SGO1 accumulated on condensed and scattered chromosomes from pre-metaphase I to metaphase II. The over-expression of SGO1 did not interfere with the process of homologous chromosome separation, although once separated they were unable to move to the opposing spindle poles. This often resulted in the formation of oocytes with 60 replicated chromosomes. Depletion of SGO1 in GV oocytes affected chromosomal separation resulting in abnormal chromosome alignment at a significantly higher proportion than in control oocytes. Knockdown of SGO1 expression significantly decreased the embryonic developmental rate and quality. To further confirm the function(s of SGO1 during mitosis, bovine embryonic fibroblast cells were transfected with SGO1 siRNAs. SGO1 depletion induced the premature dissociation of chromosomal cohesion at the centromere and along the chromosome arm giving rise to abnormal appearing mitotic patterns. The results of this study infer that SGO1 is involved in the centromeric cohesion of sister chromatids and chromosomal movement towards the spindle poles. Depletion of SGO1 causes arrestment of cell division in meiosis and mitosis.

  18. Ultraviolet light and mitomycin C induced sister-chromatid exchanges in fibroblasts from patients with retinoblastoma

    International Nuclear Information System (INIS)

    Takabayashi, T.; Lin, M.S.; Wilson, M.G.

    1984-01-01

    Ultraviolet light and mitomycin C (MMC) induced siter-chromatid exchanges (SCEs) were investigated in 6 diploid fibroblast strains derived from 3 patients with deletion 13 and retinoblastoma, one patient with a hereditary form of retinoblastoma, one patient with trisomy 13, and one normal control. Two fibroblast strains with del(13)(q14q22) showed a significant increase in SCEs compared to the control after UV and MMC treatments. In contrast, cell strains with del(13)(q12q14) and trisomy 13 did not show increased SCEs. The frequency of SCEs in fibroblasts from a patient with autosomal dominant retinoblastomas (no deletions) was significantly increased by UV, but not by MMC. The results suggest that cell strains with different deletions of chromosome 13 have different SCE responses to UV and MMC inductions. The cells with del(13)(q14q22) may have a DNA-repair defect. (orig.)

  19. SWITCH1 (SWI1): a novel protein required for the establishment of sister chromatid cohesion and for bivalent formation at meiosis

    OpenAIRE

    Mercier, Raphaël; Vezon, Daniel; Bullier, Erika; Motamayor, Juan C.; Sellier, Aurélie; Lefèvre, François; Pelletier, Georges; Horlow, Christine

    2001-01-01

    We have characterized a new gene, SWI1, involved in sister chromatid cohesion during both male and female meiosis in Arabidopsis thaliana. A first allele, swi1.1, was obtained as a T-DNA tagged mutant and was described previously as abnormal exclusively in female meiosis. We have isolated a new allele, swi1.2, which is defective for both male and female meiosis. In swi1.2 male meiosis, the classical steps of prophase were not observed, especially because homologs do not synapse. Chromatid arm...

  20. Frequencies of chromosomal aberrations and sister chromatid exchanges in the benthic worm Neanthes arenaceodentata exposed to ionizing radiation

    International Nuclear Information System (INIS)

    Harrison, F.L.; Rice, D.W. Jr.; Moore, D.H.

    1984-07-01

    Traditional bioassays are unsuitable for assessing sublethal effects from ocean disposal of low-level radioactive waste because mortality and phenotypic responses are not anticipated. We compared the usefulness of chromosomal aberration and sister chromatid exchange (SCE) induction as measures of low-level radiation effects in a sediment-dwelling marine worm, Neanthes arenaceodentata. The SCEs, in contrast to chromosomal aberrations, do not alter the overall chromosome morphology and in mammalian cells appear to be a more sensitive indicator of DNA alterations caused by environmental mutagens. Newly hatched larvae were exposed to two radiation-exposure regimes of either x rays at a high dose rate of 0.7 Gy (70 rad)/min for as long as 5.5 min or to 60 Co gamma rays at a low dose rate of from 4.8 x 10 -5 to 1.2 x 10 -1 Gy (0.0048 to 12 rad)/h for 24 h. After irradiation, the larvae were exposed to 3 x 10 -5 M bromodeoxyuridine (BrdUrd) for 28 h (x-ray-irradiated larvae) or for 54 h ( 60 Co-irradiated larvae). Larval cells were examined for the proportion of cells in first, second, and third or greater division. Frequencies of chromosomal aberrations and SCEs were determined in first and second division cells, respectively. Results from x-ray irradiation indicated that dose-related increases occur in chromosome and chromatid deletions, but a dose of equal or greater 2 Gy (equal to or greater than 200 rad) was required to observe a significant increase. Worm larvae receiving 60 Co irradiation showed elevated SCE frequencies with a significant increase of 0.6 Gy (60 rad). We suggest that both SCEs and chromosomal aberrations may be useful for measuring effects on genetic material induced by radiation. 56 references, 7 figures, 9 tables

  1. Mutagenicity of inhalation anaesthetics studied by the sister chromatid exchange test in lymphocytes of patients and operating room personnel.

    Science.gov (United States)

    Husum, B

    1987-06-01

    Retrospective studies have indicated that operating room personnel may have increased risks of spontaneous abortion, congenital malformations in offspring, and cancer (Cohen et al 1980, Buring et al 1985). Occupational exposure to waste anaesthetic gases may be responsible for these possible adverse health effects, but a cause-effect relationship has never been proved. Induction of changes in the DNA in the chromosomes leading to mutations may play a role in teratogenicity and carcinogenicity. Along with an increasing concern in society regarding occupational diseases and working and living environment in general, cytogenetic methods have been developed for rapid detection of potential mutagenicity in vitro of chemical agents. One such method is the SCE test, which is based on examination of sister chromatid exchanges (SCEs), i.e. exchanges of chromatid-segments between the two chromatids in a chromosome, during cell replication. SCEs are not mutations, but an increased frequency of SCE is a sensitive indicator of exposure to agents that are capable of producing damage to the DNA and thus possibly mutations. In vitro tests like the SCE test are very useful for evaluation of specific chemical agents, which may be added to the culture in known concentrations. In studies of possible hazards from chemical agents in the working or living environment, the exposure is often poorly defined. Also, biotransformation may be different in different species, and the duration and the level of the exposure may play a role. Examination of SCEs is, therefore, increasingly performed directly on human lymphocytes from peripheral blood. Thus, although the examination of SCEs is still performed in vitro, the exposure has taken place in vivo. Increased SCE levels are then regarded as a non-specific indicator that the donor has been exposed to potentially mutagenic agents in the environment. The author and his associates used the SCE test to investigate the possible mutagenicity of

  2. Can consumption of raw vegetables decrease the count of sister chromatid exchange? Results from a cross-sectional study in Krakow, Poland

    OpenAIRE

    Galas, Aleksander; Cebulska-Wasilewska, Antonina

    2014-01-01

    Background Sister chromatid exchange (SCE) is a widely used sensitive cytogenetic biomarker of exposure to genotoxic and cancerogenic agents. Results of human monitoring studies and cytogenetic damage have revealed that biological effects of genotoxic exposures are influenced by confounding factors related to life-style. Vegetable and fruit consumption may play a role, but available results are not consistent. The purpose of the study was to investigate the effect of consumption of raw and co...

  3. Regulation of the Drosophila Enhancer of split and invected-engrailed gene complexes by sister chromatid cohesion proteins.

    Directory of Open Access Journals (Sweden)

    Cheri A Schaaf

    2009-07-01

    Full Text Available The cohesin protein complex was first recognized for holding sister chromatids together and ensuring proper chromosome segregation. Cohesin also regulates gene expression, but the mechanisms are unknown. Cohesin associates preferentially with active genes, and is generally absent from regions in which histone H3 is methylated by the Enhancer of zeste [E(z] Polycomb group silencing protein. Here we show that transcription is hypersensitive to cohesin levels in two exceptional cases where cohesin and the E(z-mediated histone methylation simultaneously coat the entire Enhancer of split and invected-engrailed gene complexes in cells derived from Drosophila central nervous system. These gene complexes are modestly transcribed, and produce seven of the twelve transcripts that increase the most with cohesin knockdown genome-wide. Cohesin mutations alter eye development in the same manner as increased Enhancer of split activity, suggesting that similar regulation occurs in vivo. We propose that cohesin helps restrain transcription of these gene complexes, and that deregulation of similarly cohesin-hypersensitive genes may underlie developmental deficits in Cornelia de Lange syndrome.

  4. Protection of halogenated DNA from strand breakage and sister-chromatid exchange induced by the topoisomerase I inhibitor camptothecin

    International Nuclear Information System (INIS)

    Orta, Manuel Luis; Mateos, Santiago; Cantero, Gloria; Wolff, Lisa J.; Cortes, Felipe

    2008-01-01

    The fundamental nuclear enzyme DNA topoisomerase I (topo I), cleaves the double-stranded DNA molecule at preferred sequences within its recognition/binding sites. We have recently reported that when cells incorporate halogenated nucleosides analogues of thymidine into DNA, it interferes with normal chromosome segregation, as shown by an extraordinarily high yield of endoreduplication, and results in a protection against DNA breakage induced by the topo II poison m-AMSA [F. Cortes, N. Pastor, S. Mateos, I. Dominguez, The nature of DNA plays a role in chromosome segregation: endoreduplication in halogen-substituted chromosomes, DNA Repair 2 (2003) 719-726; G. Cantero, S. Mateos, N. Pastor; F. Cortes, Halogen substitution of DNA protects from poisoning of topoisomerase II that results in DNA double-strand breaks (DSBs), DNA Repair 5 (2006) 667-674]. In the present investigation, we have assessed whether the presence of halogenated nucleosides in DNA diminishes the frequency of interaction of topo I with DNA and thus the frequency with which the stabilisation of cleavage complexes by the topo I poison camptothecin (CPT) takes place, in such a way that it protects from chromosome breakage and sister-chromatid exchange. This protective effect is shown to parallel a loss in halogen-substituted cells of the otherwise CPT-increased catalytic activity bound to DNA

  5. Effects of hyperthermia and x irradiation on sister chromatid exchange (SCE) frequency in Chinese hamster ovary (CHO) cells

    International Nuclear Information System (INIS)

    Livingston, G.K.; Dethlefsen, L.A.

    1979-01-01

    The BrdUrd labeling method was used to evaluate the effects of hyperthermia, x irradiation, and the combined treatment on the incidence of sister chromatid exchange (SCE) in Chinese hamster ovary (CHO) cells. Cells cultured in McCoy's 5A media containing 10 μM 5-bromodeoxyuridine were synchronized after one cell cycle by mitotic shake-off. Early-G 1 cells were heated by submerging culture flasks in a 44 +- 0.05 0 C water bath for periods of 20, 40, and 60 min. By the same method, other cultures were x irradiated at doses of 100, 200, 400, and 600 rad. A third protocol involved combined treatment of 20 min at 44 0 C followed immediately by one of the above radiation doses. A fourth protocol reversed the sequence of the combined treatment applying x irradiation (200 or 400 rad) followed immediately by hyperthermia. The data showed that hyperthermia and x irradiation both elevated the frequency of SCEs significantly whether applied separately or together. The combined treatment (heat: 20 min at 44 0 C plus varying x-radiation doses) produced results suggestive of a synergistic interaction. The sequence of the heat and x irradiation did not appear to have a significant effect on the production of SCE

  6. Effect of chlorophyllin on induction of exchanges in sister chromatids by gamma irradiation in mice spermatogonia in vivo

    International Nuclear Information System (INIS)

    Mendiola C, M.T.

    1994-01-01

    Mouse were exposed to different doses of gamma radiation and the effect on Sister Chromatid Exchange (SCE) frequency in spermatogonias was evaluated. The effect was analyzed before and after Bromodeoxyuridine (BrdU) incorporation to determine the interference of such agent with the cellular response induced by radiation. The capacity of chlorophyllin (sodium and Copper salt derivative from chlorophyll) to reduce SCE induction by radiation in normal and BrdU radio sensitized spermatogonia was also determined. The results indicate that there was a significant increase in SCE frequency by gamma radiation exposure in these cells, such effect was higher irradiating after BrdU incorporation than before. This fact confirms previous observations that BrdU sensitizes some cells to SCE induction. With regard to the chlorophyllin effect, it was determined that this salt acts as a radioprotector reducing gamma-rays induced SCE before or after BrdU incorporation Total protection was obtained with 200 μg of chlorophyllin per g of body weight in both protocols. Under the experimental conditions this study there was no evidence of genotoxicity induced by chlorophyllin itself. The results suggest that this agent may act as a radioprotector by scavenging free radicals produced by gamma-radiation which cause DNA lesions that are involved in SCE formation. (Author)

  7. Increased UV-induced sister-chromatid exchange in cultured fibroblasts of first-degree relatives of melanoma patients

    International Nuclear Information System (INIS)

    Knees-Matzen, S.; Roser, M.; Reimers, U.; Ehlert, U.; Weichenthal, M.; Breitbart, E.W.; Ruediger, H.W.

    1991-01-01

    Cultured fibroblasts of 17 first-degree relatives of familial melanoma patients and six first-degree relatives of cutaneous melanoma (CMM) patients with multiple CMM primaries were tested for in vitro sensitivity to UV light. Fibroblasts of nine familial CMM patients with a known UV-sensitivity and 19 healthy probands served as a control. Sister chromatid exchange (SCE) was used as a parameter to detect UV-induced genotoxic damage. The authors found significantly (p less than 0.001) increased UV-induced SCE levels in familial melanoma patients, as well as in first-degree relatives of familial melanoma patients (p less than 0.001) after UV-A,B irradiation (375 J/m2), compared to the healthy probands without a family history of CMM. A significant (p less than 0.001) increase of UV-induced SCE was also observed in the relatives of CMM patients with multiple CMM primaries. In addition, the spontaneous SCE were significantly increased (p less than 0.05) in familial CMM patients. This study shows that increased UV sensitivity is a familial phenomenon. It is consistent with the concept of a genetic predisposition to CMM, which is based on increased UV sensitivity and may help to define groups with an elevated risk of developing cutaneous malignant melanoma

  8. Effect of low 60Co dose rates on sister chromatid exchange incidence in the benthic worm. Neanthes arenaceodentata

    International Nuclear Information System (INIS)

    Harrison, F.L.; Rice, D.W. Jr.

    1981-01-01

    The usefulness of sister chromatid exchange (SCE) induction as a measure of low-level radiation effect was examined in a benthic marine worm, Neanthes arenaceodentata. Larvae were exposed to 60 Co radiation for 12 to 24 h at total doses ranging from 0.5 to 309 R and at dose rates from 0.04 to 13 R/h. Animals exposed at intermediate dose rates (0.5, 0.6, 1.25, 2.0, and 2.5 R/h) had SCE frequencies per chromosome about twice that of those receiving no radiation (controls), whereas those exposed at the higher dose rates (7.0 and 13 R/h) had SCE frequencies lower than the controls. Animals exposed at the lower dose rates (0.04 and 0.1 R/h) had lower SCE frequencies than those exposed at intermediate dose rates (and higher SCE frequencies than controls). The length of chromosome pair number one differed among metaphase spreads and was used as an index of chromosome condensation in a given metaphase. Because there is a possibility that chromosome morphology may affect the ability to resolve SCEs, morphology will be monitored in future studies. A preliminary experiment was performed to assess the effects of 2.2 and 11.5 R/h for 24 h on growth and development. Larvae observed at 6 and 17 d after irradiation did not have significantly different numbers of abnormal larvae or survival rates

  9. Relationship of the demethylation of the DNA with the induction of the sister chromatid exchanges (SCE) In vivo

    International Nuclear Information System (INIS)

    Toribio E, E.

    2005-01-01

    The methylation of the DNA is an epigenetic modification that has an important paper in the regulation of the functionality of the genome of the organisms. It can be altered by demethylation processes, either natural or experimentally induced. The 5-azacytidine (Aza) is a compound that causes the demethylation of the DNA (dm-DNA), inducing with it, expression genic and increase in the frequency of the Sister Chromatid Exchange (SCE). The SCE is a genotoxicity indicator, caused by diverse mutagens and carcinogen. Since the biological meaning and the formation mechanism of this phenomenon has not been totally illustrious, the exploration of the relation between the dm-DNA and the induction of SCE, it could offer new knowledge to explain those queries. The purpose of this work was to study in cells of the mouse bone marrow In vivo, the effect of the Aza on the induction of SCE, based on two aspects: 1) dose answer and 2) the effectiveness of multiple exhibition. To six groups of three to five animals, they are administered Aza to dose of 5, 10, 15 or 20 mg/Kg of weight; in sharp or multiple form, previously to the bromodeoxyuridine supply and 24 h was sacrificed after this; 2 h after an injection with colchicine. Preparations of those metaphases were made, those which were dyed by means of a technique of fluorescence more Giemsa. It was observed that to sharp low dose, the Aza produced an increment in the frequency of SCE that although small it was proportional and statistically significant. To sharp and multiple high doses, the Aza doesn't cause additional increments of SCE, but if toxicity at cellular level and of individuals. It is concluded that a relationship exists between the dm-DNA and the induction of SCE. It is suggested that the total demethylation of the DNA causes 2 SCE/Cell in cells of the mouse bone marrow, or that the cytotoxicity prevents to evidence a bigger induction. (Author)

  10. Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination

    Energy Technology Data Exchange (ETDEWEB)

    Nagasawa, H; Wilson, P F; Chen, D J; Thompson, L H; Bedford, J S; Little, J B

    2007-10-26

    We reported previously that the homologous recombinational repair (HRR)-deficient Chinese hamster mutant cell line irs3 (deficient in the Rad51 paralog Rad51C) showed only a 50% spontaneous frequency of sister chromatid exchange (SCE) as compared to parental wild-type V79 cells. Furthermore, when irradiated with very low doses of alpha particles, SCEs were not induced in irs3 cells, as compared to a prominent bystander effect observed in V79 cells (Nagasawa et al., Radiat. Res. 164, 141-147, 2005). In the present study, we examined additional Chinese hamster cell lines deficient in the Rad51 paralogs Rad51C, Rad51D, Xrcc2, and Xrcc3 as well as another essential HRR protein, Brca2. Spontaneous SCE frequencies in non-irradiated wild-type cell lines CHO, AA8 and V79 were 0.33 SCE/chromosome, whereas two Rad51C-deficient cell lines showed only 0.16 SCE/chromosome. Spontaneous SCE frequencies in cell lines defective in Rad51D, Xrcc2, Xrcc3, and Brca2 ranged from 0.23-0.33 SCE/chromosome, 0-30% lower than wild-type cells. SCEs were induced significantly 20-50% above spontaneous levels in wild-type cells exposed to a mean dose of 1.3 mGy of alpha particles (<1% of nuclei traversed by an alpha particle). However, induction of SCEs above spontaneous levels was minimal or absent after {alpha}-particle irradiation in all of the HRR-deficient cell lines. These data suggest that Brca2 and the Rad51 paralogs contribute to DNA damage repair processes induced in bystander cells (presumably oxidative damage repair in S-phase cells) following irradiation with very low doses of alpha particles.

  11. New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.

    Science.gov (United States)

    Gellon, Lionel; Razidlo, David F; Gleeson, Olive; Verra, Lauren; Schulz, Danae; Lahue, Robert S; Freudenreich, Catherine H

    2011-02-10

    Expansion of DNA trinucleotide repeats causes at least 15 hereditary neurological diseases, and these repeats also undergo contraction and fragility. Current models to explain this genetic instability invoke erroneous DNA repair or aberrant replication. Here we show that CAG/CTG tracts are stabilized in Saccharomyces cerevisiae by the alternative clamp loader/unloader Ctf18-Dcc1-Ctf8-RFC complex (Ctf18-RFC). Mutants in Ctf18-RFC increased all three forms of triplet repeat instability--expansions, contractions, and fragility--with effect over a wide range of allele lengths from 20-155 repeats. Ctf18-RFC predominated among the three alternative clamp loaders, with mutants in Elg1-RFC or Rad24-RFC having less effect on trinucleotide repeats. Surprisingly, chl1, scc1-73, or scc2-4 mutants defective in sister chromatid cohesion (SCC) did not increase instability, suggesting that Ctf18-RFC protects triplet repeats independently of SCC. Instead, three results suggest novel roles for Ctf18-RFC in facilitating genomic stability. First, genetic instability in mutants of Ctf18-RFC was exacerbated by simultaneous deletion of the fork stabilizer Mrc1, but suppressed by deletion of the repair protein Rad52. Second, single-cell analysis showed that mutants in Ctf18-RFC had a slowed S phase and a striking G2/M accumulation, often with an abnormal multi-budded morphology. Third, ctf18 cells exhibit increased Rad52 foci in S phase, often persisting into G2, indicative of high levels of DNA damage. The presence of a repeat tract greatly magnified the ctf18 phenotypes. Together these results indicate that Ctf18-RFC has additional important functions in preserving genome stability, besides its role in SCC, which we propose include lesion bypass by replication forks and post-replication repair.

  12. Sister chromatid exchanges in the bone marrow cells of in vivo rats induced by gamma radiation and chemical mutagens

    International Nuclear Information System (INIS)

    Rodriguez R, R.G.

    1981-01-01

    Sister chromatid exchanges (SCE) in the bone marrow of in vivo rats induced by gamma radiation doses and by the chemical mutagens, mitomycin C (MMC), cyclophosphamide (CP), and sulphonate-methylmethane (SMM), were studied. The purpose was to evaluate the sensitivity and reproducibility of a simplified SCE in vivo detecting system developed in our laboratory and to compare the results obtained with those reported elsewhere. Simplification consisted in administering the amounts of 5-bromo-2'-deoxyuridine (BrdU) necessary to observe the SCE, after first adsorbing the BrdU in activated carbon and then injecting it interperitoneally, into the rats. The results were a longer time in vivo ADN incorporation without convulsions in the rats, and a reduction in the time course as compared to other methods. We observed a basal rate of 3.6+-0.37 SCE/cell and that: 0.44 Gy of gamma radiation induced 7.7+-0.73 SCE/cell; 1.6 μg/g of MMC induced 8.1+-1.20 SCE/cell; 5 μg/g of CP induced 8.25+-1.5 SCE/cell, 40 μg/g of SMM induced 22.0+-5 SCE/cell and 380 μg/g of sulphonate-ethylmethane induced 8.6+-1.2 SCE/cell. This showed that all the agents were capable of inducing SCE in the bone marrow cells of rats in vivo under our conditions. We noted a greater induced efficiency for gamma radiation than the obtained by other investigators and a relatively similar efficiency in the case of chemical mutagens as reported in other studies. (author)

  13. Excision and crosslink repair of DNA and sister chromatid exchanges in cultured human fibroblasts with different repair capacities

    International Nuclear Information System (INIS)

    Fujiwara, Yoshisada; Kano, Yoshio; Paul, P.; Goto, Kaoru; Yamamoto, Kazuo

    1981-01-01

    Xeroderma pigmentosum (XP) groups A to G lacked the initial stage of ultraviolet (UV) excision repair in the order of A = G > C > D > E asymptotically equals F, while the XP variant was weakly defective in the later repair steps. Killing sensitivities were in the orders of A >= G > D > C > E asymptotically equals F asymptotically equals variant > normal to UV, A = G > D > F > C = E > variant > normal to 4-nitroquinoline-1-oxide (4NQO), and A > C > D = E = F = variant > G = normal to decarbamoyl mitomycin-C(DCMC). The induced sister chromatid exchange (SCE) frequency was unrelated to the extent of repair deficiency. The SCE induction rate was consistently 3 - 6 fold higher by these UV-like mutagens in XP group A cells than in normal cells. However, repair-proficient Cockayne's syndrome (CS) cells showed a higher SCE induction by UV, which was normalized by NAD + , suggesting that chromatin lesions as well as DNA damage contribute to SCE. Two-step crosslink repair involves a first rapid half-excision and a second slow nucleotide-excision repair. Fanconi's anemia (FA) cells had an impaired first half-excision and were supersensitive to MC, but not to UV and DCMC. The SCE frequency induced by MC (1 hr) was higher in FA cells than in normal cells despite their normal response to DCMC, and vice versa in XP cells. FA cells lacked the first rapid decline and showed higher remaining SCEs. Thus, part of the crosslink seems to lead to SCE formation. Caffeine synergistically elevated UV-induced SCEs, but not UV induced mutations in V79 cells, implying that SCE may not necessarily involve mutation. (J.P.N.)

  14. Relationship of DNA repair to chromosome aberrations, sister-chromatid exchanges and survival during liquid-holding recovery in X-irradiated mammalian cells

    International Nuclear Information System (INIS)

    Fornace, A.J. Jr.; Nagasawa, H.; Little, J.B.

    1980-01-01

    The repair of X-ray-induced DNA single strand breaks and DNA-protein cross-links was investigated in stationary phase, contact-inhibited mouse cells by the alkaline-elution technique. Approx. 90% of X-ray-induced single strand breaks were rejoined during the first hour of repair, whereas most of the remaining breaks were rejoined more slowly during the next 5 h. At early repair times, the number of residual non-rejoined sungle strand breaks was approx. proportional to the X-ray dose. DNA-protein cross-links were removed at a slower rate (Tsub(1/2) approx. 10-12 h). Cells were held in stationary growth for various periods of time after irradiation before subculture at low density to score for colony survival (potentially lethal damage repair), chromosome aberrations in the first mitosis, and sister-chromatid exchanges in the second mitosis. Both cell killing and the frequency of chromosome aberrations decreased during the first several hours of recovery, reaching a minimum level by 6 h; this decrease correlated temporally with the repair of the slowly rejoining DNA-strand breaks. Relatively few sister-chromatid exchanges were observed when the cells were subcultured immediately after X-ray. The exchange frequency rose to maximum levels after a 4-h recovery interval, and returned to control levels after 12 h of recovery. The possible relationship of DNA repair to these changes in survival, chromosome aberrations, and sister-chromatid exchanges during liquid-holding recovery is discussed. (orig.)

  15. Increased sister chromatid cohesion and DNA damage response factor localization at an enzyme-induced DNA double-strand break in vertebrate cells.

    LENUS (Irish Health Repository)

    Dodson, Helen

    2009-10-01

    The response to DNA damage in vertebrate cells involves successive recruitment of DNA signalling and repair factors. We used light microscopy to monitor the genetic dependencies of such localization to a single, induced DNA double strand break (DSB) in vertebrate cells. We used an inducible version of the rare-cutting I-SceI endonuclease to cut a chromosomally integrated I-SceI site beside a Tet operator array that was visualized by binding a Tet repressor-GFP fusion. Formation of gamma-H2AX foci at a single DSB was independent of ATM or Ku70. ATM-deficient cells showed normal kinetics of 53Bp1 recruitment to DSBs, but Rad51 localization was retarded. 53Bp1 and Rad51 foci formation at a single DSB was greatly reduced in H2AX-null DT40 cells. We also observed decreased inter-sister chromatid distances after DSB induction, suggesting that cohesin loading at DSBs causes elevated sister chromatid cohesion. Loss of ATM reduced DSB-induced cohesion, consistent with cohesin being an ATM target in the DSB response. These data show that the same genetic pathways control how cells respond to single DSBs and to multiple lesions induced by whole-cell DNA damage.

  16. Effects of coal combustion products and metal compounds on sister chromatid exchange (SCE) in a macrophagelike cell line.

    Science.gov (United States)

    Andersen, O

    1983-01-01

    Investigations of genotoxic effects of particles have almost exclusively been performed by organic extraction, while direct investigations in cells capable of engulfing particles have only been performed in few cases. Thus, in most studies, the eventual effects of particle-associated metal compounds have remained undiscovered. The present study attempted direct measurement of genotoxic effects of particulate coal combustion products by using the P388D(1) macrophage cell line. The capability of these cells for phagocytosis was demonstrated with insoluble particles. The sister chromatid exchange (SCE) test was used for measuring genotoxic effects of test compounds. Dimethylnitrosamine and benzo(a)pyrene did not increase SCE, indicating that the P388D(1) cell line has lost the capacity for metabolism of latent organic carcinogens, reducing the value of these cells for evaluating genotoxic effects of complex particles. Indirect evidence has been obtained that the cell line may be infected with a virus. Thus, interactions between virus and test compound may lead to erroneous results. This should be kept in mind during evaluation of the results. The effects of metals with reported carcinogenic or mutagenic effects on SCE were compared in P388D(1) cells and human lymphocytes: NaAsO(2), CdCl(2), K(2)Cr(2)O(7), CoCl(2), CH(3)HgCl and MnSO(4) increased SCE in both cell systems. Pb(CH(3)COO)(2), BeSO(4) and NiSO(4) had a weak effect on SCE in P388D(1). Pb(CH(3)COO)(2) and NiSO(4), but not BeSO(4), increased SCE in human lymphocytes. Cr(CH(3)COO)(3) increased SCE in human lymphocytes at high concentration, but was a strong inducer of increased SCE in P388D(1) cells, which take up Cr(III) by phagocytosis. This suggests that the Cr(III) ion is an ultimate carcinogenic form of chromium. Generally P388D(1) cells and human lymphocytes respond to in vitro exposure to metals in agreement with reported mutagenic/carcinogenic effects of the metals. Of four precipitated coal fly ash

  17. INVESTIGATION OF DNA REPAIR BY SISTER CHROMATID EXCHANGE (SCE) ANALYSIS AND THE ALKALINE SINGLE CELL GEL ASSAY (SCG) IN MAMMALIAN GO-LYMPHOCYTES AFTER IN VITRO EXPOSURE TO ETHYLENE OXIDE (EO)

    Science.gov (United States)

    Investigation ofDNA Repair by Sister Chromatid Exchange (SCE) Analysis and the Alkaline Single Cell Gel Assay (SCG) in Mammalian Go-Lymphocytes after In Vitro Exposure to Ethylene Oxide (EO). EO is a large volume chemical used primarily as an intermediate in manufacturing...

  18. Induction of sister chromatid exchanges in fibroblasts from normal donors and from patients with xeroderma pigmentosum after combined treatment with ultraviolet radiation and modulated low frequency electric currents.

    Science.gov (United States)

    Fackel, N; Dertinger, H; Wolf, G K

    1998-01-01

    Dermal fibroblasts derived from normal donors as well as from patients with xeroderma pigmentosum (XP) were exposed in vitro to ultraviolet radiation of 254 nm wavelength and to weak electric 4, 000 Hz currents modulated in amplitude with 50 Hz. Treatment with this so-called interferential current (IFC) increased the rate of sister chromatid exchanges (SCE) in all fibroblast types up to roughly 50% above the spontaneous level. When IFC was applied in combination with UV-radiation, it lowered UV-induced increase of the SCE-rate. A reduction of UV-induced SCEs was seen when XP-cells were exposed to IFC prior to UV-treatment, compared to the reverse order of treatment. The order of exposure has only been analysed in 5 XP patients, not in normal donors. The relationships between different combinations of exposure parameters (IFC-amperage, UV-dose, cell pathology, order of treatment) were examined by analysis of variance (ANOVA).

  19. Assessment of DNA Damage in Peripheral Blood Lymphocytes of Radiation Workers at Al-Tuwaitha Site by Using the Sister Chromatid Exchange and the Comet Assay

    International Nuclear Information System (INIS)

    Ali, A.K.; Muttar, A.J.; Khayon, S.K.; Haider, Y.L.; Ali, H.F.; Abdullah, A.K.

    2015-01-01

    The sister chromatid exchange was performed on peripheral blood lymphocytes obtained from 40 individuals of workers occupationally exposed to low ionizing radiation doses in Al-Tuwaitha site due to decommissioning to radioactive contamination then compared with 40 control individuals living in Baghdad. SCEs were scored in metaphase chromosomes were identified by fluorescent plus Giemsa staining (Figure 2).The mean frequencies of SCEs per cell differed significantly (p≺0 0.05) between individuals of radiation workers and control, being 7.78 0.45 SCE/cells and 6.28 0.22 SCE/cells , respectively. However SCE frequency was statistically significant (P≺0 0.05) among radiation workers as compared to control individuals.

  20. Effect of chlorophyllin on frequency radiation-induced of sister chromatid exchanges (SCE) and other cytogenetic events in mice bone marrow cells In Vivo

    International Nuclear Information System (INIS)

    Garcia Rodriguez, M.C.

    1992-01-01

    The effect of chlorophyllin on gamma radiation induced Sister chromatid exchanges (SCE) and on the mitotic index (IM) and average generation time was determined. Groups of mice were treated in one of the following regimens: (1) untreated, (2) treated with chlorophyllin only, (3) irradiated and (4) treated with chlorophyllin and irradiated intraperitoneal administration of chlorophyllin preceding gamma radiation exposure protected again SCE induction and diminution of IM. However, radioprotection was not reflected in the average generation time for the chlorophyllin per se acceleration the average generation time. The results suggest that, under the experimental conditions of the study the SCE and IM are caused by free radicals produced by radiation and wat the action mechanics of chlorophyllin is scavenger free radicals. (Author)

  1. Elevated frequency of sister chromatid exchanges in lymphocytes of victims of the Tokyo sarin disaster and in experiments exposing lymphocytes to by-products of sarin synthesis.

    Science.gov (United States)

    Li, Q; Minami, M; Clement, J G; Boulet, C A

    1998-09-01

    More than 5000 passengers of Tokyo subway trains were injured with toxic chemicals including the nerve gas sarin. Most of the victims examined had marked miosis and decreased serum cholinesterase activity. To monitor the genetic aftereffects of sarin exposure, we measured sister chromatid exchanges (SCEs) of the victims using peripheral blood lymphocytes. The frequency of SCEs was significantly higher in the victims than in the control group. Analyzing results using samples of urine from the victims suggested that the victims were exposed to not only sarin per se, but by-products of sarin synthesis, i.e. diisopropyl methylphosphonate (DIMP), diethyl methylphosphonate (DEMP) and ethyl isopropyl methylphosphonate (EIMP). Thus, the in vitro SCE-inducing effect of DIMP, DEMP and EIMP was examined using human lymphocytes and we obtained positive results.

  2. A comparative investigation of DNA strand breaks, sister chromatid exchanges and K-ras gene mutations induced by cadmium salts in cultured human cells

    International Nuclear Information System (INIS)

    Mouron, Silvana Andrea; Grillo, Claudia Alejandra; Dulout, Fernando Noel; Golijow, Carlos Daniel

    2004-01-01

    Cadmium (Cd) is a toxic heavy metal of continuing occupational and environmental concern with a wide variety of adverse effects. Several studies have shown that cadmium produces DNA strand breaks, DNA-protein cross-links, oxidative DNA damage, chromosomal aberrations, dysregulation of gene expression resulting in enhanced proliferation, depressed apoptosis and/or altered DNA repair. This study was undertaken to investigate the ability of cadmium chloride (CdCl 2 ) and cadmium sulphate (CdSO 4 ) to induce point mutations in codon 12 of the K-ras protooncogene assessed by polymerase chain reaction-single strand conformation polymorphisms (PCR-SSCP) and RFLP-enriched PCR methods. Also their genotoxic effects were analyzed by the comet assay and sister chromatid exchanges test. The human lung fibroblast cell line MRC-5 was used for the experiments. Sister chromatid exchanges assay (SCEs) frequencies were significantly increased in cells exposed to cadmium salts in relation to controls (p < 0.001). Despite the slow increment observed in the three comet parameters considered when cells were treated with cadmium chloride, significant differences between groups were only found in the variable comet moment (CM) (p < 0.005). On the other hand, when cells were exposed to cadmium sulphate, the Kruskal-Wallis test showed highly significant differences between groups for migration, tail moment and comet moment parameters (p < 0.001). Nevertheless, a null or weak point mutation induction in K-ras protooncogene was detected using polymerase chain reaction-low ionic strength-single strand conformation polymorphisms (PCR-LIS-SSCP) and RFLP-enriched PCR methods when cells were treated with cadmium salts. Thus, inorganic cadmium produces genotoxicity in human lung fibroblast MRC-5 cells, in the absence of significant point mutation of the K-ras gene

  3. Enhanced stimulation of chromosomal translocations and sister chromatid exchanges by either HO-induced double-strand breaks or ionizing radiation in Saccharomyces cerevisiae yku70 mutants

    Energy Technology Data Exchange (ETDEWEB)

    Fasullo, Michael [Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12209 (United States)]. E-mail: mfasullo@ordwayresearch.org; St Amour, Courtney [Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12209 (United States); Zeng Li [Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12209 (United States)

    2005-10-15

    DNA double-strand break (DSB) repair occurs by homologous recombination (HR) or non-homologous endjoining (NHEJ). In Saccharomyces cerevisiae, expression of both MAT a and MAT{alpha} inhibits NHEJ and facilitates DSB-initiated HR. We previously observed that DSB-initiated recombination between two his3 fragments, his3-{delta}5' and his3-{delta}3'::HOcs is enhanced in haploids and diploids expressing both MAT a and MAT{alpha} genes, regardless of the position or orientation of the his3 fragments. Herein, we measured frequencies of DNA damage-associated translocations and sister chromatid exchanges (SCEs) in yku70 haploid mutants, defective in NHEJ. Translocation and SCE frequencies were measured in strains containing the same his3 fragments after DSBs were made directly at trp1::his3-{delta}3'::HOcs. Wild type and yku70 cells were also exposed to ionizing radiation and radiomimetic agents methyl methanesulfonate (MMS), phleomycin, and 4-nitroquinolone-1-oxide (4-NQO). Frequencies of X-ray-associated and DSB-initiated translocations were five-fold higher in yku70 mutants compared to wild type; however, frequencies of phleomycin-associated translocations were lower in the yku70 haploid mutant. Frequencies of DSB-initiated SCEs were 1.8-fold higher in the yku70 mutant, compared to wild type. Thus, DSB-initiated HR between repeated sequences on non-homologous chromosomes and sister chromatids occurs at higher frequencies in yku70 haploid mutants; however, higher frequencies of DNA damage-associated HR in yku70 mutants depend on the DNA damaging agent.

  4. Enhanced stimulation of chromosomal translocations and sister chromatid exchanges by either HO-induced double-strand breaks or ionizing radiation in Saccharomyces cerevisiae yku70 mutants

    International Nuclear Information System (INIS)

    Fasullo, Michael; St Amour, Courtney; Zeng Li

    2005-01-01

    DNA double-strand break (DSB) repair occurs by homologous recombination (HR) or non-homologous endjoining (NHEJ). In Saccharomyces cerevisiae, expression of both MAT a and MATα inhibits NHEJ and facilitates DSB-initiated HR. We previously observed that DSB-initiated recombination between two his3 fragments, his3-Δ5' and his3-Δ3'::HOcs is enhanced in haploids and diploids expressing both MAT a and MATα genes, regardless of the position or orientation of the his3 fragments. Herein, we measured frequencies of DNA damage-associated translocations and sister chromatid exchanges (SCEs) in yku70 haploid mutants, defective in NHEJ. Translocation and SCE frequencies were measured in strains containing the same his3 fragments after DSBs were made directly at trp1::his3-Δ3'::HOcs. Wild type and yku70 cells were also exposed to ionizing radiation and radiomimetic agents methyl methanesulfonate (MMS), phleomycin, and 4-nitroquinolone-1-oxide (4-NQO). Frequencies of X-ray-associated and DSB-initiated translocations were five-fold higher in yku70 mutants compared to wild type; however, frequencies of phleomycin-associated translocations were lower in the yku70 haploid mutant. Frequencies of DSB-initiated SCEs were 1.8-fold higher in the yku70 mutant, compared to wild type. Thus, DSB-initiated HR between repeated sequences on non-homologous chromosomes and sister chromatids occurs at higher frequencies in yku70 haploid mutants; however, higher frequencies of DNA damage-associated HR in yku70 mutants depend on the DNA damaging agent

  5. Cytogenetic effects of grape extracts (Vitis vinifera) and polyphenols on mitomycin C-induced sister chromatid exchanges (SCEs) in human blood lymphocytes.

    Science.gov (United States)

    Stagos, Dimitrios; Spanou, Chrysa; Margariti, Maria; Stathopoulos, Constantinos; Mamuris, Zissis; Kazantzoglou, Georgios; Magiatis, Prokopios; Kouretas, Demetrios

    2007-06-27

    In the present study, the effects of extracts and polyphenol-rich fractions as well as monomer polyphenols identified in them, from both red and white grapes, on mitomycin C (MMC) induced sister chromatid exchanges (SCEs) in human peripheral blood lymphocytes were investigated. The grape extracts and two of the three polyphenol-rich fractions promoted MMC-induced SCEs at concentrations from 75 to 300 microg/mL. However, none of the extracts or fractions alone induced SCEs. Thus, these results suggest caution especially with regard to the use of grape extracts as dietary supplements. On the other hand, the fact that these extracts were not genotoxic alone may indicate a selective activity against genetically damaged cells. This is the first study regarding the clastogenic effects of grape extracts in human cells. Moreover, from the tested polyphenols, caffeic acid, gallic acid, and rutin hydrate enhanced MMC-induced clastogenicity, whereas ferulic acid, protocatechuic acid, (+)-catechin, (-)-epicatechin, and trans-resveratrol had no effect at concentrations between 5 and 100 microM. The differences in the chemical structures of the tested polyphenols may account for their differential effects on MMC clastogenicity.

  6. Antigenotoxic activity of Thai Sangyod red rice extracts against a chemotherapeutic agent, doxorubicin, in human lymphocytes by sister chromatid exchange (SCE) assay in vitro.

    Science.gov (United States)

    Ratanavalachai, Treetip; Thitiorul, Sumon; Tanuchit, Sermkiat; Jansom, Chalerm; Uttama, Sakultala; Itharat, Arunporn

    2012-01-01

    Nowadays, anticarcinogenic potential of pigmented brown rice and rice bran varieties have been increasingly stated. However, their mechanisms of action are still inconclusive. One of which might be their antigenotoxic activity that no study in human cells was reported before. To evaluate the antigenotoxic activities of Thai Sangyod red rice extracts against a chemotherapeutic agent, doxorubicin, by sister chromatid exchange (SCE) assay in human lymphocytes in vitro. Two fractions of water-soluble of Sangyod rice extracts were used: (i) the washed water extract of brown rice (WWBR) and (ii) the water extract of rice bran (WERB). Human lymphocytes were pretreated with each extracts at concentrations of 6.2, 12.5, 25, 50 and 100 microg/ml for 2 h followed by a genotoxic agent, doxorubicin (DXR) (0.1 microg/ml) for 2 h. SCE level, mitotic index (MI) and proliferation index (PI) were evaluated. Statistical analysis by Dunnett's t-test was performed. The results indicated that the pretreatment of WERB fraction only at concentration of 6.2 microg/ml could significantly decrease SCE level as compared to that of the DXR treated alone (p rice extracts.

  7. Characterization of the enhancing effect of caffeine on sister-chromatid exchanges induced by ultraviolet radiation in excision-proficient xeroderma pigmentosum lymphoblastoid cells

    International Nuclear Information System (INIS)

    Thoda, Hiroko; Oikawa, Atsushi

    1988-01-01

    Cells of some excision-proficient xeroderma pigmentosum (XP) cell lines are highly sensitive to post-UV caffeine treatment in terms of sister-chromatid exchange (SCE) induction as well as cell lethality. In the present study, the authors conducted a detailed investigation of the enhancing effect of caffeine on SCE frequency induced by UV in excision-proficient XP cells, and obtained the following results. (1). Continuous post-UV treatment with 1mM caffeine markedly enhances UV-induced SCEs and such enhanced SCEs occur with similar frequency during either the 1st or the 2nd cell cycle in the presence of caffeine and 5-bromodeoxyuridine (BrdUrd). (2) The high sensitivity of the cells to post-UV caffeine treatment persists for at least 2 days after UV when irradiated cells are held in either the proliferating of the nonproliferating state prior to the addition of BrdUrd. (3) Caffeine exerts its effect on cells in S phase. The most likely explanation for our findings is as follows. In excision-proficient XP cells, the cause of SCE formation such as UV-induced lesions or resulting perturbations of DNA replication persists untill the 2nd round or more of post-UV DNA replication. If caffeine is given as post-UV treatment, such abnormalities may be amplified, resulting in a synergistic increase in SCE frequency. (author). 21 refs.; 4 figs.; 4 tabs

  8. Inhibitory effects of sizofiran on anticancer agent- or X-ray-induced sister chromatid exchanges and mitotic block in murine bone marrow cells

    International Nuclear Information System (INIS)

    Yang, Zhi-Bo; Tsuchiya, Yoshinori; Arika, Tadashi; Hosokawa, Masuo.

    1993-01-01

    The inhibitory effects of a biological response modifier (RRM), sizofiran, on sister chromatid exchanges (SCEs) in the bone marrow cells of mice treated with various anticancer agents or irradiation were investigated. Sizofiran (10 mg/kg i.m.) inhibited SCEs induced by mitomycin C (2 mg/kg i.v.), adriamycin (20 mg/kg i.v.) and cyclophosphamide (20 mg/kg i.v.) by about 20%, respectively. Analysis of the SCEs in vivo after irradiation plus sizofiran indicated that SCE levels were significantly lower than those observed in mice exposed to irradiation without sizofiran. Moreover, the effects of sizofiran were dependent on the timing of administration. Our results indicated that sizofiran should be administered simultaneously or soon after irradiation in order to minimize damage. Sizofiran also markedly restored the bone marrow cell mitosis which had been suppressed by anticancer agents, and this action was closely correlated with the prevention of increase in SCEs. These results indicate that in addition to immunopotentiating activity, sizofiran may play a role in preventing chromosomal damage induced by cancer chemotherapy and radiotherapy. (author)

  9. Can consumption of raw vegetables decrease the count of sister chromatid exchange? Results from a cross-sectional study in Krakow, Poland.

    Science.gov (United States)

    Galas, Aleksander; Cebulska-Wasilewska, Antonina

    2015-03-01

    Sister chromatid exchange (SCE) is a widely used sensitive cytogenetic biomarker of exposure to genotoxic and cancerogenic agents. Results of human monitoring studies and cytogenetic damage have revealed that biological effects of genotoxic exposures are influenced by confounding factors related to life-style. Vegetable and fruit consumption may play a role, but available results are not consistent. The purpose of the study was to investigate the effect of consumption of raw and cooked vegetables and fruits on SCE frequency. A total of 62 participants included colorectal cancer (CRC) patients, hospital-based controls and healthy laboratory workers. SCE frequency was assessed in blood lymphocytes. Frequency of vegetable and fruit consumption was gathered by structured semi-quantitative food frequency questionnaire. SCE frequency was lowest among hospital-based controls (4.4 ± 1.1), a bit higher in CRC patients (4.5 ± 1.0) and highest among laboratory workers (7.4 ± 1.2) (p consumption, but not so for intake of cooked vegetables and fruits. The results of the study have shown the beneficial effect of consumption of raw vegetables on disrupted replication of DNA measured by SCE frequency, implying protection against genotoxic agents. Further effort is required to verify the role of cooked vegetables and fruits.

  10. Repairability during G 1 phase of inducting lesions of sister chromatid exchange produced by mitomycin C in salivary gland cells of mice In Vivo

    International Nuclear Information System (INIS)

    Cruz Vallejo, V.L.

    1991-01-01

    The repairability of the injuries that lead to the formation of sister chromatid exchange (SCE) produced by mitomycin C (MMC) with a dose of 2.1 mg/g in vivo, during the G 1 phase in the first cycle of cellular division (before the incorporation of BrdU [5-bromo-2 deoxyurine] to the DNA), as well as during the G 1 phase of the second cycle of cellular division (after the incorporation of BrdU) were analyzed. A 35.1% decrease in the frequency of SCE produced by Mitomycin C was observed, in the early G 1 phase of the first division, with respect to the frequency of SCE induced in the later G 1 phase. When Mitomycin C is given to cells whose DNA is substituted with BrdU in only one of the chain's filaments such decrease is not observed. The results suggest that the injuries caused by MMC, which give place to the SCE, in cells of the salivary glands of the mouse in vivo, are partially repaired only when induced in DNA which has not been substituted with BrdU. (Author)

  11. Variation in the human lymphocyte sister chromatid exchange frequency as a function of time: results of daily and twice-weekly sampling

    Energy Technology Data Exchange (ETDEWEB)

    Tucker, J.D.; Christensen, M.L.; Strout, C.L.; McGee, K.A.; Carrano, A.V.

    1987-01-01

    The variation in lymphocyte sister chromatid exchange (SCE) frequency was investigated in healthy nonsmokers who were not taking any medication. Two separate studies were undertaken. In the first, blood was drawn from four women twice a week for 8 weeks. These donors recorded the onset and termination of menstruation and times of illness. In the second study, blood was obtained from two women and two men for 5 consecutive days on two separate occasions initiated 14 days apart. Analysis of the mean SCE frequencies in each study indicated that significant temporal variation occurred in each donor, and that more variation occurred in the longer study. Some of the variation was found to be associated with the menstrual cycle. In the daily study, most of the variation appeared to be random, but occasional day-to-day changes occurred that were greater than those expected by chance. To determine how well a single SCE sample estimated the pooled mean for each donor in each study, the authors calculated the number of samples that encompassed that donor's pooled mean within 1 or more standard errors. For both studies, about 75% of the samples encompassed the pooled mean within 2 standard errors. An analysis of high-frequency cells (HFCs) was also undertaken. The results for each study indicate that the proportion of HFCs, compared with the use of Fisher's Exact test, is significantly more constant than the means, which were compared by using the t-test. These results coupled with our previous work suggest that HFC analysis may be the method of choice when analyzing data from human population studies.

  12. Evaluation of the persistence in the induction of Sister Chromatid Exchanges (SCE) by alkylating agents; Evaluacion de la persistencia en la induccion de Intercambio en las Cromatidas Hermanas (ICH) por agentes alquilantes

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez R, R.; Huerta V, C.; MOrales R, P.R. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2006-07-01

    The persistence in the induction of sister chromatid exchanges (SCE) by the alkylating agents methyl and ethyl-methanesulfonates (MMS and EMS) was evaluated. For it, to groups of mice its were administered a dose of these agents and later its were analyzed the induced SCE's in two periods: early and late. Both agents caused high increments of SCE in the early period and small in the late one; however, the caused lately by EMS was significantly bigger. This late induction of SCE by EMS possibly is associated with an epigenetic change or with the presence of etiladucts in the phosphodiester bonds of the DNA. (Author)

  13. Comparison of 6-thioguanine-resistant mutation and sister chromatid exchanges in Chinese hamster V79 cells with forty chemical and physical agents.

    Science.gov (United States)

    Nishi, Y; Hasegawa, M M; Taketomi, M; Ohkawa, Y; Inui, N

    1984-08-01

    The induction of sister chromatid exchanges (SCE) and mutation at the hypoxanthine-guanine phosphoribosyl transferase locus and toxicities of 40 different chemical and physical agents were examined on Chinese hamster V79 cells. These agents included mono-, di-, tri-, and polyfunctional alkylating agents, intercalators, gamma-rays, and UV light irradiation. Mutation was measured as resistance to 6-thioguanine and toxicity as loss of cell-plating efficiency. SCE were examined 29 hr after treatment. With the agents examined, a highly positive correlation (r = 0.89) existed between SCE-inducing and mutagenic potencies, when expressed as increase in the number per a unit dose over the control values. But the great difference of the ratios of mutagenic potencies versus SCE-inducing potencies among agents was observed, the maximal difference in the ratios being about 200-fold. The agents that showed the higher values of the ratio (agents producing more mutations than SCE) were bleomycin, cobalt-60 gamma-rays, all ethylating agents (N-ethyl-N-nitrosourea, N-ethyl-N'-nitro-N-nitrosoguanidine, ethyl methanesulfonate, and diethylsulfate), N-propyl-N-nitrosourea, N-butyl-N-nitrosourea, isopropyl methanesulfonate, intercalating acridine compounds (2-methoxy-6-chloro-9-[3-(ethyl-2-chloroethyl)aminopropylamino]-acridine X 2HCl and 2-methoxy-6-chloro-9-[3-(chloroethyl)-aminopropylamino]acridine 2HCl) and UV light at 254 nm. The agents that showed the lower values (agents producing more SCE than mutations) were platinum compounds (cis-diamminedichloro-platinum and trans-diamminedichloroplatinum), epoxides (epichlorohydrin, styrene oxide, and diepoxybutane) and aziridines (mitomycin C, decarbamoyl mitomycin C, tris(1-aziridinyl)phosphine sulfide, triethylenemelamine, and carboquone). The agents that showed the intermediate values included all methylating agents (N-methyl-N-nitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine, methyl methanesulfonate, and dimethyl sulfate), N-(2

  14. Effects of a tumor promoter and an anti-promoter on spontaneous and UV-induced 6-thioguanine-resistant mutations and sister-chromatid exchanges in V79 Chinese hamster cells

    International Nuclear Information System (INIS)

    Fujiwara, Y.; Kano, Y.; Tatsumi, M.; Paul, P.

    1980-01-01

    The effects of a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and/or an anti-promoter antipain (protease inhibitor) on spontaneous and ultraviolet-induced sister-chromatid exchanges (SCEs) and 6-thioguanine-resistant (6TGsup(r)) recessive mutations were examined in V79 Chinese hamster cells in culture. TPA and/or antipain neither significantly altered base-line and UV-induced immediate SCE frequencies, nor decreased the level of delayed SCEs which persisted 6-7 days after irradiation. TPA and/or antipain appeared to enhance the recovery of UV-induced 6TGsup(r) colonies at the plateau expression phase despite non-mutagenicity by themselves and unaltered metabolic cooperation. Thus, the results conceivably imply that the 6TGsup(r)-recessive mutation expression, but not fixation, can be modulated at the cell level by TPA and/or antipain. Our results, together with the recent results of Loveday and Latt, may argue against the notion that TPA enhances the antipain-suppressible SCEs as an index of mitotic recombination in relevance with a tumor-promotion mechanism. (orig.)

  15. Evidence that cyclophosphamide can to induce exchanges in the sister chromatids (ICH) through secondary injuries; Evidencia de que la ciclofosfamida puede inducir intercambios en las cromatidas hermanas (ICH) a traves de lesiones secundarias

    Energy Technology Data Exchange (ETDEWEB)

    Morales R, P.; Rodriguez R, R. [Instituto Nacional de Investigaciones nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    By means of the use of destination protocol of ICH inductive injuries (DLI-ICH), it was studied if interchanges in the sister chromatids (ICH) induced by cyclophosphamide (CP), in the second post-treatment division (ICH-2) are produced by secondary injuries or by fresh injuries. For discard between these possibilities it was administered CP at different periods before of the first post-treatment division, taking as reference the administered time for high dose of bromodeoxyuridine (BrdU ) which was approximately at the beginning of this division. The ICH frequencies that occur in the first, the second and the third synthesis stages (S) were determined. It was observed that when the administered CP was four hours before BrdU , the ICH frequencies of the second and the third S were reduced. The frequency of the first ICH increased lightly in relation to those of the normal protocol (0.5 h before BrdU ) and that the supplying of CP six hours before caused almost a total reduction of ICH of second and third S and an important increment of ICH of first S.This was interpreted as evidence that the ICH-2 are product of secondary injuries. (Author)

  16. Repairability during G1 of the inductor leisure of exchanges in the sister chromatid induced by alkylating agents in DNA substituted and no substituted with BUDR, in cells of the salivary gland of mouse In vivo

    International Nuclear Information System (INIS)

    Gonzalez B, F.

    2004-01-01

    In this work you determines the repair of the lesions inductoras of Sister chromatid exchange (ICHs) generated in the cells of the salivary gland of mouse, for the treatment with the N-Methyl-N-Nitrosourea (MNU), the N-Ethyl-N-Nitrosourea (ENU), the Methyl methanesulfonate (MMS) and the Ethyl methanesulfonate (EMS) in early and slow G1 of the first one and the second cellular division, that is to say before and after the cells incorporate 5-bromine-2 -Desoxyuridine (BrdU) in the DNA. Groups witness non treaties were included with mutagen. The cells of the salivary gland repaired the generated lesions partially by the MNU, the MMS and the EMS in the 1st division, and only the lesions induced by the ENU and MMS were repaired partially in the 2nd division. The ENU generates injure that they were not repaired in the 1st division and those taken place by the EMS were little repaired in the 2nd division. The methylating agents generated but ICHs that the ethylating. One observes that the BrdU makes to the molecule of the DNA but susceptible to the damage generated by the alkylating agents that induce the formation of the ICHs. This susceptibility was incremented around 150% for the treatment with the MNU, the ENU and the MMS, on the other hand for the EMS it was 3 times minor. It is proposed that the one electronegative atom of this analog of the timine would to work as a nucleophyllic center with which the electrophyllic compounds react. (Author)

  17. Relationship of the demethylation of the DNA with the induction of the sister chromatid exchanges (SCE) In vivo; Relacion de la desmetilacion del ADN con la induccion de intercambios en las cromatidas hermanas (ICH) In vivo

    Energy Technology Data Exchange (ETDEWEB)

    Toribio E, E

    2005-07-01

    The methylation of the DNA is an epigenetic modification that has an important paper in the regulation of the functionality of the genome of the organisms. It can be altered by demethylation processes, either natural or experimentally induced. The 5-azacytidine (Aza) is a compound that causes the demethylation of the DNA (dm-DNA), inducing with it, expression genic and increase in the frequency of the Sister Chromatid Exchange (SCE). The SCE is a genotoxicity indicator, caused by diverse mutagens and carcinogen. Since the biological meaning and the formation mechanism of this phenomenon has not been totally illustrious, the exploration of the relation between the dm-DNA and the induction of SCE, it could offer new knowledge to explain those queries. The purpose of this work was to study in cells of the mouse bone marrow In vivo, the effect of the Aza on the induction of SCE, based on two aspects: 1) dose answer and 2) the effectiveness of multiple exhibition. To six groups of three to five animals, they are administered Aza to dose of 5, 10, 15 or 20 mg/Kg of weight; in sharp or multiple form, previously to the bromodeoxyuridine supply and 24 h was sacrificed after this; 2 h after an injection with colchicine. Preparations of those metaphases were made, those which were dyed by means of a technique of fluorescence more Giemsa. It was observed that to sharp low dose, the Aza produced an increment in the frequency of SCE that although small it was proportional and statistically significant. To sharp and multiple high doses, the Aza doesn't cause additional increments of SCE, but if toxicity at cellular level and of individuals. It is concluded that a relationship exists between the dm-DNA and the induction of SCE. It is suggested that the total demethylation of the DNA causes 2 SCE/Cell in cells of the mouse bone marrow, or that the cytotoxicity prevents to evidence a bigger induction. (Author)

  18. Role of oxidative stress and intracellular calcium in nickel carbonate hydroxide-induced sister-chromatid exchange, and alterations in replication index and mitotic index in cultured human peripheral blood lymphocytes

    Energy Technology Data Exchange (ETDEWEB)

    M' Bemba-Meka, Prosper [Universite de Montreal, Human Toxicology Research Group (TOXHUM), Department of Environmental and Occupational Health, Main Station, P.O. Box 6128, Montreal, QC (Canada); University of Louisville, Department of Pharmacology and Toxicology, Center for Genetics and Molecular Medicine, Louisville, KY (United States); Lemieux, Nicole [Universite de Montreal, Department of Pathology and Cellular Biology, Faculty of Medicine, Main Station, P.O. Box 6128, Montreal, QC (Canada); Chakrabarti, Saroj K. [Universite de Montreal, Human Toxicology Research Group (TOXHUM), Department of Environmental and Occupational Health, Main Station, P.O. Box 6128, Montreal, QC (Canada)

    2007-02-15

    Human peripheral lymphocytes from whole blood cultures were exposed to either soluble form of nickel carbonate hydroxide (NiCH) (0-60 {mu}M), or of nickel subsulfide (Ni{sub 3}S{sub 2}) (0-120 {mu}M), or of nickel oxide (NiO) (0-120 {mu}M), or nickel sulfate (NiSO{sub 4}) (0-120 {mu}M) for a short duration of 2 h. The treatments occurred 46 h after the beginning of the cultures. The cultures were harvested after a total incubation of 72 h, and sister-chromatid exchange (SCE), replication index (RI), and mitotic index (MI) were measured for each nickel compound. The soluble form of NiCH at 30 {mu}M but those of Ni{sub 3}S{sub 2} and NiO at 120 {mu}M produced significant increase in the SCE per cell compared to the control value, whereas NiSO{sub 4} failed to produce any such significant increase. Except NiSO{sub 4}, the soluble forms of NiCH, Ni{sub 3}S{sub 2}, and NiO produced significant cell-cycle delay (as measured by the inhibition of RI) as well as significant inhibition of the MI at respective similar concentrations as mentioned above. Pretreatment of human blood lymphocytes with catalase (H{sub 2}O{sub 2} scavenger), or superoxide dismutase (superoxide anion scavenger), or dimethylthiourea (hydroxyl radical scavenger), or deferoxamine (iron chelator), or N-acetylcysteine (general antioxidant) inhibited NiCH-induced SCE, and changes in RI and MI. This suggests the participation of oxidative stress involving H{sub 2}O{sub 2}, the superoxide anion radical, the hydroxyl radical, and iron in the NiCH-induced genotoxic responses. Cotreatment of NiCH with either verapamil (inhibitor of intracellular calcium ion ([Ca{sup 2+}]{sub i}) movement through plasma membranes), or dantrolene (inhibitor of [Ca{sup 2+}]{sub i} release from sarcoplasmic reticulum), or BAPTA (Ca{sup 2+} chelator) also inhibited the NiCH-induced responses. These results suggest that [Ca{sup 2+}]{sub i} is also implicated in the genotoxicity of NiCH. Overall these data indicate that various types

  19. Repairability during G1 of the inductor leisure of exchanges in the sister chromatid induced by alkylating agents in DNA substituted and no substituted with BUDR, in cells of the salivary gland of mouse In vivo; Reparabilidad durante G1 de las lesiones inductoras de intercambios en las cromatidas hermanas inducidos por agentes alquilantes en ADN sustituido y no sustituido con BrdU, en celulas de la glandula salival de raton In vivo

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez B, F

    2004-07-01

    In this work you determines the repair of the lesions inductoras of Sister chromatid exchange (ICHs) generated in the cells of the salivary gland of mouse, for the treatment with the N-Methyl-N-Nitrosourea (MNU), the N-Ethyl-N-Nitrosourea (ENU), the Methyl methanesulfonate (MMS) and the Ethyl methanesulfonate (EMS) in early and slow G1 of the first one and the second cellular division, that is to say before and after the cells incorporate 5-bromine-2 -Desoxyuridine (BrdU) in the DNA. Groups witness non treaties were included with mutagen. The cells of the salivary gland repaired the generated lesions partially by the MNU, the MMS and the EMS in the 1st division, and only the lesions induced by the ENU and MMS were repaired partially in the 2nd division. The ENU generates injure that they were not repaired in the 1st division and those taken place by the EMS were little repaired in the 2nd division. The methylating agents generated but ICHs that the ethylating. One observes that the BrdU makes to the molecule of the DNA but susceptible to the damage generated by the alkylating agents that induce the formation of the ICHs. This susceptibility was incremented around 150% for the treatment with the MNU, the ENU and the MMS, on the other hand for the EMS it was 3 times minor. It is proposed that the one electronegative atom of this analog of the timine would to work as a nucleophyllic center with which the electrophyllic compounds react. (Author)

  20. Phospho-H1 Decorates the Inter-chromatid Axis and Is Evicted along with Shugoshin by SET during Mitosis.

    Science.gov (United States)

    Krishnan, Swathi; Smits, Arne H; Vermeulen, Michiel; Reinberg, Danny

    2017-08-17

    Precise control of sister chromatid separation during mitosis is pivotal to maintaining genomic integrity. Yet, the regulatory mechanisms involved are not well understood. Remarkably, we discovered that linker histone H1 phosphorylated at S/T18 decorated the inter-chromatid axial DNA on mitotic chromosomes. Sister chromatid resolution during mitosis required the eviction of such H1S/T18ph by the chaperone SET, with this process being independent of and most likely downstream of arm-cohesin dissociation. SET also directed the disassembly of Shugoshins in a polo-like kinase 1-augmented manner, aiding centromere resolution. SET ablation compromised mitotic fidelity as evidenced by unresolved sister chromatids with marked accumulation of H1S/T18ph and centromeric Shugoshin. Thus, chaperone-assisted eviction of linker histones and Shugoshins is a fundamental step in mammalian mitotic progression. Our findings also elucidate the functional implications of the decades-old observation of mitotic linker histone phosphorylation, serving as a paradigm to explore the role of linker histones in bio-signaling processes. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Chromatid interchanges at intrachromosomal telomeric DNA sequences

    International Nuclear Information System (INIS)

    Fernandez, J.L.; Vazquez-Gundin, F.; Bilbao, A.; Gosalvez, J.; Goyanes, V.

    1997-01-01

    Chinese hamster Don cells were exposed to X-rays, mitomycin C and teniposide (VM-26) to induce chromatid exchanges (quadriradials and triradials). After fluorescence in situ hybridization (FISH) of telomere sequences it was found that interstitial telomere-like DNA sequence arrays presented around five times more breakage-rearrangements than the genome overall. This high recombinogenic capacity was independent of the clastogen, suggesting that this susceptibility is not related to the initial mechanisms of DNA damage. (author)

  2. The Lehman Sisters Hypothesis

    NARCIS (Netherlands)

    I.P. van Staveren (Irene)

    2014-01-01

    markdownabstract__Abstract__ This article explores the Lehman Sisters Hypothesis. It reviews empirical literature about gender differences in behavioral, experimental, and neuro-economics as well as in other fields of behavioral research. It discusses gender differences along three dimensions of

  3. 40 CFR 79.65 - In vivo sister chromatid exchange assay.

    Science.gov (United States)

    2010-07-01

    ... metaphase portion of the cell cycle and presumably requires the enzymatic incision, translocation and... to optimize the sample collection time for second division metaphase cells. (ii) This assay may be... added to arrest cell growth in c-metaphase. Cells are harvested 4 hours later and second-division...

  4. A study of sister chromatid exchange in patients with dental amalgam restorations

    Directory of Open Access Journals (Sweden)

    E Lakshmi Priya

    2014-01-01

    Conclusion: Systemic genotoxicity was not observed due to the components of amalgam restorations released during its placement and chronic use. The findings of this study can be considered as preliminary information on the systemic toxicity due to the components of amalgam restorations.

  5. Sister Chromatid Exchange Assay of Nitroguanidine in Chinese Hamster Ovary Cells

    Science.gov (United States)

    1988-07-01

    W. HarbellI , >LAJ, MSC; LilIi ic 1). Witcher , SGT, USA; Don W. Korte, Jr.,1- -NE 1;7 PEPORT 󈧑b TIME COiVERED 1 ATE OF REPORT (Year, Month, Day) 15...Investigator LIILIf- D WITCHER , i /_ Dat- SGT, U-A CC.iKBA2 R. WHEELER, PhD / Date DAC Analytical Chemist v •N DEPARTMENT OF THE ARMY LETTERMIAN ARMY...carcinogens. M.tat Res 1977; 48: 337-354. 7. Harbell JW, Witcher LD, Sebastian SE, Korte DW. Studies on the mutagenic potential of nitrocuanidine and

  6. Probing the mechanism of sister chromatid exchange formation with the fluorescent plus Giemsa technique

    International Nuclear Information System (INIS)

    Yu, L.C.

    1976-01-01

    The effects of x rays and light flashes on the SCE formation in BrdUrd-substituted Chinese hamster ovary (CHO) cells are examined using the fluorescent plus Giemsa (FPG) technique, which allows SCE's to be visualized with greater precision than 3 H autoradiography does. Near-diploid cells are selected and scoring SCE from every chromosome of near-diploid cells or from chromosome no. 1 is found to give a more accurate measure of the SCE induction. Double synchronous cells are used for the x ray study and asynchronous cells are used for the light flash study. The results indicate that x rays can induce SCE's throughout the cell cycle with S the most sensitive stage and G 2 the least sensitive stage. Light flashes can induce an appreciable amount of SCE's while no appreciable amount of chromosomal aberrations can be detected under conditions used in this study. For x-ray-induced chromosomal aberrations, G 2 is the most sensitive stage with G 1 being slightly more sensitive than S, which is consistent with other observations. Additionally, aberration induction is shown to be a more sensitive indicator of x-ray-induced cell damage than SCE induction, but SCE induction is a potentially good indicator of mutation induction. This study also suggests that symmetrically reunited isochromatid breaks can not be the sole source of SCE's and SCE induction is a different but not independent radiobiological effect from chromosomal aberration induction. SCE formation is proposed to be a consequence of specific type(s) of single strand breaks in DNA

  7. Fanconi anaemia proteins are associated with sister chromatid bridging in mitosis

    DEFF Research Database (Denmark)

    Ying, Songmin; Hickson, Ian D

    2011-01-01

    that specifically occur during chromosome segregation in mitosis. The BS protein, BLM, was shown recently to define a novel class of anaphase DNA bridge structures that, in some cases, also contain FA proteins. We will discuss the possible source of these bridges and the role that FA proteins and BLM might play...

  8. PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis

    DEFF Research Database (Denmark)

    Nielsen, Christian Thomas Friberg; Huttner, Diana; Bizard, Anna H

    2015-01-01

    PICH is a SNF2 family DNA translocase that binds to ultra-fine DNA bridges (UFBs) in mitosis. Numerous roles for PICH have been proposed from protein depletion experiments, but a consensus has failed to emerge. Here, we report that deletion of PICH in avian cells causes chromosome structural......-193-treated cells. We propose that PICH and Topo II cooperate to prevent chromosome missegregation events in mitosis....

  9. Effect of tritiated compounds on sister-chromatid exchanges (SCE) in human lymphocytes in vitro

    International Nuclear Information System (INIS)

    Gong Manli; Rao Yongqing; Chen Guanying; Wu Weiwei; Zhao Zilan; Shen Lei

    1990-01-01

    Human lymphocytes treated in vitro with various activities of 3 H-TdR and 3 H-UdR were cultured to understand the effects of tritium on the cell cycle and the frequency of SCE. The results of these experiments indicated that both tritiated compounds make the frequency of SCE increase and the cell cycle delay. The frequency of SCE increased markedly with activity of 3 H. With respect to delaying cell cycle, 3 H-UdR was more effective than 3 H-TdR. The average frequencies of SCE for 3 H-UdR were higher than those for 3 H-TdR. With the exception of 3.7 x 10 3 Bq/mL group and differences between other 3 H-UdR groups and corresponding 3 H-TdR group were significant (t test, p < 0.01). These results suggest that tritiated compounds may have the effect on the cell proliferating rate. The cell proliferating rate index (PRI) seems to be related with the frequency of SCE: the higher the frequency of SCE, the lower the PRI is

  10. DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange.

    Directory of Open Access Journals (Sweden)

    Hungjiun Liaw

    Full Text Available Hyperphosphorylation of RPA2 at serine 4 and serine 8 (S4, S8 has been used as a marker for activation of the DNA damage response. What types of DNA lesions cause RPA2 hyperphosphorylation, which kinase(s are responsible for them, and what is the biological outcome of these phosphorylations, however, have not been fully investigated. In this study we demonstrate that RPA2 hyperphosphorylation occurs primarily in response to genotoxic stresses that cause high levels of DNA double-strand breaks (DSBs and that the DNA-dependent protein kinase complex (DNA-PK is responsible for the modifications in vivo. Alteration of S4, S8 of RPA2 to alanines, which prevent phosphorylations at these sites, caused increased mitotic entry with concomitant increases in RAD51 foci and homologous recombination. Taken together, our results demonstrate that RPA2 hyperphosphorylation by DNA-PK in response to DSBs blocks unscheduled homologous recombination and delays mitotic entry. This pathway thus permits cells to repair DNA damage properly and increase cell viability.

  11. Homologous recombination, sister chromatid cohesion, and chromosome condensation in mammalian meiosis

    NARCIS (Netherlands)

    Eijpe, M.

    2002-01-01

    In the life cycle of sexually reproducing eukaryotes, haploid and diploid generations of cells alternate. Two types of cell division occur in such a life cycle: mitosis and meiosis. They are compared in chapter 1 . Haploid and

  12. Effect of cysteamine on sister chromatid exchange (SCE) induction by gamma rays

    International Nuclear Information System (INIS)

    Mendiola Cruz, M.T.

    1987-01-01

    The effect of different doses of cysteamine (3, 15 and 150 μg/g bw) on gamma ray-induced SCE was evaluated and compared with the responses obtained with regard to frequency of chromosomal aberrations, frequency of proliferating cells and the rate of cellular proliferating kinetics in mouse bone marrow cells in vivo. Groups of mice were either irradiated, treated with cysteamine and irradiated, only treated with cysteamine or left without treatment for determination of these parameters. The intraperitoneal administration of cysteamine preceding 1 Gy of gamma ray exposure, produces a dose dependent radioprotection on SCE-induction obtaining the greatest effect with 150 μg/g bw. However, this effect was not observed in the mitotic index nor in the average generation time. Chromosomic aberrations in animals irradiated after treatment with cysteamine were also detected. It was not observed any citotoxic or genotoxic effect produced by cysteamine per se. The results suggest that, under the experimental conditions of this study, the SCE are caused by free radicals produced by gamma radiation; not so, the additional damage indexes measured. (author)

  13. Measuring Sister Chromatid Cohesion Protein Genome Occupancy in Drosophila melanogaster by ChIP-seq.

    Science.gov (United States)

    Dorsett, Dale; Misulovin, Ziva

    2017-01-01

    This chapter presents methods to conduct and analyze genome-wide chromatin immunoprecipitation of the cohesin complex and the Nipped-B cohesin loading factor in Drosophila cells using high-throughput DNA sequencing (ChIP-seq). Procedures for isolation of chromatin, immunoprecipitation, and construction of sequencing libraries for the Ion Torrent Proton high throughput sequencer are detailed, and computational methods to calculate occupancy as input-normalized fold-enrichment are described. The results obtained by ChIP-seq are compared to those obtained by ChIP-chip (genomic ChIP using tiling microarrays), and the effects of sequencing depth on the accuracy are analyzed. ChIP-seq provides similar sensitivity and reproducibility as ChIP-chip, and identifies the same broad regions of occupancy. The locations of enrichment peaks, however, can differ between ChIP-chip and ChIP-seq, and low sequencing depth can splinter broad regions of occupancy into distinct peaks.

  14. Friel and his "sisters"

    Directory of Open Access Journals (Sweden)

    Nicholas Grene

    2010-11-01

    Full Text Available This essay, occasioned by a revival of Brian Friel's version of Chekhov's Three Sisters at the Abbey Theatre in 2008, considers the circumstances surrounding its first production by the Field Day Theatre Company in 1981, and the motivation behind the decision to translate Chekhov's text into a specifically Irish dialect of English. It also analyses how Friel's plays since that date, notably the award-winning Dancing at Lughnasa (1990, have changed our perspective on the play.

  15. On the radiosensitivity of uni- and bi-filiary BrdUrd-substituted chromatids

    International Nuclear Information System (INIS)

    Luchnik, N.V.; Antoshchina, M.M.; Porjadkova, N.A.

    1981-01-01

    The present report will suggest that a difference between the quality of radiation used rather than interspecies differences seems to be a more probable cause of the existing contradictions. Cultured Chinese hamster cells (line 237 A) synchronized in G 1 stage by starvation and human lymphocytes from healthy donors were incubated in Eagle medium with 20% bovine serum. BrdUrd (10 -5 M) was present during the entire period of incubation. Irradiation with 1 Gy of 60 Co γ-rays at 0.4 Gy/min was given in the G 2 stage of the second mitotic cycle (Chinese hamster cells were fixed 1-4 h after irradiation, human lymphocytes 1.5-2.5 h after irradiation). The slides were illuminated with a bacteriocidal UV source and stained with azur-eosine. This technique gives an excellent differentiation between sister chromatids without use of Hoechst 33258 (Antoshchina and Porjadkova, 1978). Some slides were analysed twice to assure that the probability to detect a break in TB and BB chromatids was the same. In such cases, the slide was first stained with azur-eosine by the usual technique, and after analysis it was bleached in ethanol, illuminated by UV and restained to obtain differentiation. (orig./AJ)

  16. Left-right symmetry breaking in mice by left-right dynein may occur via a biased chromatid segregation mechanism, without directly involving the Nodal gene

    Directory of Open Access Journals (Sweden)

    Stephan eSauer

    2012-11-01

    Full Text Available Ever since cloning the classic iv mutation identified the ‘left-right dynein’ (lrd gene in mice, most research on body laterality determination has focused on its function in motile cilia at the node embryonic organizer. This model is attractive, as it links chirality of cilia architecture to asymmetry development. However, lrd is also expressed in blastocysts and embryonic stem cells, where it was shown to bias the segregation of recombined sister chromatids away from each other in mitosis. These data suggested that lrd is part of a cellular mechanism that recognizes and selectively segregates sister chromatids based on their replication history: old ‘Watson’ vs. old ‘Crick’ strands. We previously proposed that the mouse left-right axis is established via an asymmetric cell division prior to/or during gastrulation. In this model, left-right dynein selectively segregates epigenetically differentiated sister chromatids harboring a hypothetical ‘left-right axis development 1’ (‘lra1’ gene during the left-right axis establishing cell division. Here, asymmetry development would be ultimately governed by the chirality of the cytoskeleton and the DNA molecule. Our model predicts that randomization of chromatid segregation in lrd mutants should produce embryos with 25% situs solitus, 25% situs inversus, and 50% embryonic death due to heterotaxia and isomerism. Here we confirmed this prediction by using two distinct lrd mutant alleles. Other than lrd, thus far Nodal gene is the most upstream function implicated in visceral organs laterality determination. We next tested whether the Nodal gene constitutes the lra1 gene hypothesized in the model by testing mutant’s effect on 50% embryonic lethality observed in lrd mutants. Since Nodal mutation did not suppress lethality, we conclude that Nodal is not equivalent to the lra1 gene. In summary, we describe the origin of 50% lethality in lrd mutant mice not yet explained by any other

  17. Left-right symmetry breaking in mice by left-right dynein may occur via a biased chromatid segregation mechanism, without directly involving the Nodal gene

    International Nuclear Information System (INIS)

    Sauer, Stephan; Klar, Amar J. S.

    2012-01-01

    Ever since cloning the classic iv (inversedviscerum) mutation identified the “left-right dynein” (lrd) gene in mice, most research on body laterality determination has focused on its function in motile cilia at the node embryonic organizer. This model is attractive, as it links chirality of cilia architecture to asymmetry development. However, lrd is also expressed in blastocysts and embryonic stem cells, where it was shown to bias the segregation of recombined sister chromatids away from each other in mitosis. These data suggested that lrd is part of a cellular mechanism that recognizes and selectively segregates sister chromatids based on their replication history: old “Watson” versus old “Crick” strands. We previously proposed that the mouse left-right axis is established via an asymmetric cell division prior to/or during gastrulation. In this model, left-right dynein selectively segregates epigenetically differentiated sister chromatids harboring a hypothetical “left-right axis development 1” (“lra1”) gene during the left-right axis establishing cell division. Here, asymmetry development would be ultimately governed by the chirality of the cytoskeleton and the DNA molecule. Our model predicts that randomization of chromatid segregation in lrd mutants should produce embryos with 25% situs solitus, 25% situs inversus, and 50% embryonic death due to heterotaxia and isomerism. Here we confirmed this prediction by using two distinct lrd mutant alleles. Other than lrd, thus far Nodal gene is the most upstream function implicated in visceral organs laterality determination. We next tested whether the Nodal gene constitutes the lra1 gene hypothesized in the model by testing mutant’s effect on 50% embryonic lethality observed in lrd mutants. Since Nodal mutation did not suppress lethality, we conclude that Nodal is not equivalent to the lra1 gene. In summary, we describe the origin of 50% lethality in lrd mutant mice not yet explained by any other

  18. "Sister to the tailor"

    DEFF Research Database (Denmark)

    Simonton, Deborah

    2017-01-01

    Milliners, and their sisters, mantuamakers, modistes and marchandes de mode, were skilled artisans, businesswomen and tradeswomen. During the eighteenth century, they commandeered the high-class sewing that set fashion and created stars of their most famous, like Rose Bertrand, milliner to Marie...... Antoinette. They populated the growing towns of Europe and used their design and business acumen to create a virtual profession out of a handicraft. They also encountered resistance from guilds and guildsmen who tried to retain their control over commercial sewing, and certainly the bespoke and honourable...

  19. Sister-sister incest: data from an anonymous computerized survey.

    Science.gov (United States)

    Stroebel, Sandra S; O'Keefe, Stephen L; Griffee, Karen; Kuo, Shih-Ya; Beard, Keith W; Kommor, Martin J

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using a computer-assisted self-interview. Thirty-one participants were victims of sister-sister incest, 40 were victims of brother-sister incest, 19 were victims of father-daughter incest, 8 were victims of sexual abuse by an adult female (including one mother), and 232 were victims of sexual abuse by an adult male other than their father before reaching 18 years of age. The rest (1,203) served as controls. The victims of sister-sister incest had significantly more problematic outcomes than controls on many measures as adults. Victims of sister-sister incest were more depressed and more likely than controls to be distant from the perpetrator-sister and to have traded sex for money, experienced an unplanned pregnancy, engaged in four different types of masturbation, and engaged in 13 different same-sex behaviors. Our findings were consistent with other reports of early eroticization and persistent hypereroticization of incest victims.

  20. Enhanced G2 chromatid radiosensitivity in dyskeratosis congenita fibroblasts

    International Nuclear Information System (INIS)

    DeBauche, D.M.; Pai, G.S.; Stanley, W.S.

    1990-01-01

    Dyskeratosis congenita (DC) is an inherited disorder characterized by reticular pigmentation of the skin, dystrophic nails, mucosal leukoplakia, and a predisposition to cancer in early adult life. In the majority of cases, DC is an X-linked recessive trait. However, one or more autosomal form(s) of DC may exist. Although excessive spontaneous chromatid breakage has been reported in DC, it is not a consistent cytological marker for this disorder. We examined the frequency and specificity of X-irradiation-induced G2 chromatid breakage in fibroblasts from three unrelated DC patients (two males and one female). Metaphase cells from DC patients had significantly more chromatid breaks (16-18-fold and 17-26-fold at 50 and 100 rad X-irradiation, respectively) and chromatid gaps (10-12-fold and 6-7-fold at 50 and 100 rad, respectively) than those from two different controls. Analysis of banded chromosomes revealed a nonrandom distribution of chromatid aberrations in DC but not in controls, a distribution corresponding to some of the known breakpoints for cancer-specific rearrangements, constitutive fragile sites, and/or loci for cellular proto-oncogenes. The significance of this finding for cancer predisposition in DC patients is uncertain, but the increased susceptibility of X-irradiation-induced chromatid breakage may serve as a cellular marker of diagnostic value

  1. Two Nepali Sisters

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    to Denmark and Seattle. They both use the connections and skills acquired in Japan, but one is now living in Seattle and the other in Kathmandu. One is a manager in a chocolate factory using Danish products in the Seattle area and the other has started an income generating environmental NGO in Nepal while......Diaspora is an expansion of a national or family network that can be activated for the benefit of the family and home nation in multiple ways. The argument is based on two life stories. Two Nepali sisters attended Association of Overseas Technical Scholarships (AOTS) training courses in Japan...... at different times during the 1980s. The training was partly funded by official development assistance provided through the Japanese Ministry of International Trade and Industry (MITI). They used their training very differently, but between the two of them extended a family network from Japan and India...

  2. Where are Sedna's Sisters?

    Science.gov (United States)

    Bartlett, D. F.

    2005-05-01

    Simulations of the formation of the Oort cloud from the Kuiper Belt typically are presented as an animated scatter diagram. Here the orbit of each object appears as a point of perihelion distance q and semi-major axis a. (eg. Levison, Morbidelli, & Dones 2004). These plots show a conspicuous void, bounded by the inequalities: q 50 AU, and a Bermuda Triangle". The only present occupant is Sedna (q=76 AU, a=501 AU). Brown, Trujillo, & Rabinowitz , the discovers of Sedna, have challenged others to explain how Sedna got inside the triangle and to predict where similar objects might be found. Sedna could not have simply formed in its current orbit by the accumulation of smaller objects (Stern 2005). Several authors have suggested that a passing star scattered Sedna into the triangle shortly after the birth of the solar system. Here I offer an alternative which uses the very strong galactic tidal forces of the Sinusoidal potential (Bartlett 2001, 2004). In this potential, the numerator of Newton's law is replaced by GM cos(ko r) where ko = 2 π / lambdao and the 'wavelength' λ o is 425 pc. The 20 radial oscillations between the sun and the center of the Galaxy give tidal forces that are 120 times as big as generally expected. I will show how this tidal force, acting over the lifetime of the solar system, could move the perihelion of Sedna from about 40 to 76 AU. Sedna's sisters are likely to have still larger q & a and to have perihelia in two specific quadrants of the ecliptic plane.

  3. Sisters Hope - the exposed self

    DEFF Research Database (Denmark)

    Lawaetz, Anna; Hallberg, Gry Worre

    can we create a ‘learning space’ or a ‘research lab’, where the participants are inspired to approach their project in a new way with the outset in bodily and somatic experiences within the space? And how can we understand and distinguish what we understand to be the exposed self and the poetic self…......’ and the establishment of fictional spaces outside the institutional art context. In the Unfolding Academia-context Sisters Hope investigates new forms of research and (re)presentation through the creation of interactive and affective learning-spaces. At Collective Futures Sisters Hope explored questions such as: How...

  4. IUTAM Symposium

    CERN Document Server

    1995-01-01

    The International Union of Theoretical and Applied Mechanics (IUTAM) decided in 1992 to sponsor the fourth Symposium on Laminar-Turbulent Transition, Sendai/Japan, 1994. The objectives of the present Symposium were to deepen the fundamental knowledge of stability and laminar­ turbulent transition in three-dimensional and compressible flows and to contribute to recent developing technologies in the field. This Symposium followed the three previous IUTAM-Symposia (Stuttgart 1979, Novosibirsk 1984 and Toulouse 1989). The Scientific Committee selected two keynote lectures and 62 technical papers. The Symposium was held on the 5th to 9th of September, 1994, at the Sendai International Center in Sendai. The participants were 82 scientists from 10 countries. The keynote lectures have critically reviewed recent development of researches concerning the laminar-to-turbulent transition phenomena from the fundamental and the application aspects. Many papers presented were concerned about the detailed mechanism of the bo...

  5. A Symposium.

    Science.gov (United States)

    Rachal, John R.

    2003-01-01

    Uses the framework of a symposium to present an imagined discussion by historical figures about whether and how knowledge might be acquired. Discussants include Democritus, Protagoras, Heraclitus, Socrates, Jesus, Gorgias, Nietzsche, Buddha, and Kierkegaard. (Contains 40 endnotes.) (SK)

  6. Field Verification Program (Aquatic Disposal). Sister Chromatid Exchange in Marine Polychaetes Exposed to Black Rock Harbor Sediment.

    Science.gov (United States)

    1985-07-01

    17. Hargraves, 1. 1986. "The Mysterious Bay Bloom of 85," Maritimes, Vol 30, pp 7-9. * ~hooftman, R. N., and Vink, G. J. 1981. "Cytogenetic Effects on...34Evaluation of the _E’cherichla coZi K12 Inductest for Jetection of Potential Chemical Carcinogens," Mutation Research, Vol 130, pp l 4-151. McCann, J., Choi

  7. Study of cell cycle parameters of man lymphocytes irradiated at various stages using differential coloring of sister chromatides

    International Nuclear Information System (INIS)

    Poryadkova, N.A.

    1984-01-01

    Parameters of the cell cycle of human lymphocytes are specified, radiation effect applied at various stages of mitotic cycle on the kinetics of cell advance in the cycle is also investigated. It is shown that increasing mitotic index occurs only due to the introduction of cells into the first mitosis. It is not excluded that cells ready to enter the second mitosis died with greater probability as after second synthesis they contained two-fold amount of BDU (5-brominedesoxiuridine) than cells of the first mitosis. In all cases with irradiation of cells of the third mitosis were not found

  8. Sister Chromatid Exchanges (=SCEs) in Lymphocytes of persons working at Shlobin (USSR), 150km north of Chernobyl

    International Nuclear Information System (INIS)

    Tuschl, H.; Kovac, R.

    1988-08-01

    SCEs are considered to be a sensitive indicator for the DNA damaging effects of mutagenic and carcinogenic agents. In 1986, during the Chernobyl accident, employees of an Austrian company worked at Shlobin, 150km north of Chernobyl. At their return to Austria blood as taken and spontaneously occurring and MMC induced SCEs were studied. Spontaneously occurring SCEs in lymphocytes of 'exposed' and 'unexposed' persons were only insignificantly different when results were summarized for all test persons. A significant influence of smoking could be established. When results were correlated with the time interval between the Chernobyl accident and the date of blood sampling, the increased rate of spontaneous SCEs observed soon after the accident decreased to the normal range during the following months. Irrespective of the molecular mechanism that might be the rationale for the observed decreased induction of SCEs in lymphocytes of exposed persons, the estimation of MMC induced SCEs proved to be the most sensitive test to demonstrate population exposure to low doses of ionizing radiation. 7 refs., 1 fig., 5 tabs. (Author)

  9. Parallel increases in sister chromatid exchanges at base level and with UV treatment in human opiate users

    International Nuclear Information System (INIS)

    Shafer, D.A.; Falek, A.; Madden, J.J.; Tadayon, F.; Pline, M.; Kuehnle, J.C.; Mendelson, J.

    1983-01-01

    The SCE base level frequency and SCE levels induced by far-UV (254 nm) treatment of cells in early G 1 and early S phases of the cell cycle were significantly higher in leukocytes from heroin addicts as compared to controls. The increased SCE levels in addicts was greatest at base level and smallest after UV irradiation of cells in S phase. These results corrobate and extend our previous findings of increased chromosome damage and reduced DNA-repair synthesis in heroin users. Since opiates do not directly damage DNA, the elevated cytogenetic effects associated with opiate use probably arise from secondary promotional effects related to opiate-mediated alterations in leukocyte metabolism. (orig.)

  10. The modulating effect of retinoids and a tumor promoter on malignant transformation, sister chromatid exchanges, and Na/K ATPase

    International Nuclear Information System (INIS)

    Borek, C.; Miller, R.C.; Geard, C.R.; Guernsey, D.; Osmak, R.S.; Rutledge-Freeman, M.; Ong, A.; Mason, H.

    1981-01-01

    In earlier reports we have shown that a vitamin A analog inhibits radiation-induced transformation in vitro and that retinoids and TPA exert antagonistic effects on vitamin A-binding protein production. Since the tumor promoter TPA has been reported to enhance radiation-induced transformation, it seemed a logical step to follow up these various studies and to investigate whether the antagonism between vitamin A and TPA on cell differentiation in vitro prevails in their effects on radiation-induced transformation in vitro

  11. IUTAM Symposium

    CERN Document Server

    Whitelaw, James; Wung, T

    1992-01-01

    A Symposium on Aerothermodynamics of Combustors was held at the Institute of Applied Mechanics of the National Taiwan University from 3 to 5 June 1991 and was attended by 130 delegates from eight countries. The topics of the forty formal presentations included measurements and calculations of isothermal simulations and of combusting flows with one and two phases, and with consideration of configurations ranging from simple diffusion to gas-turbine flows. The discussions inside and outside of the Symposium Hall were lively and an open forum session demonstrated the range of opinions currently and strongly held. The International Union of Theoretical and Applied Mechanics initiated the Symposium under the chairmanship of Professor R S L Lee and with the Scientific Committee listed below. It benefited from sponsorship, again as listed below, and from contributors who presented interesting and up-to-date descriptions of their research. Invited lectures were delivered by Professors R Bilger and F Weinberg and set ...

  12. Fuel wood symposium; Symposium Energieholz

    Energy Technology Data Exchange (ETDEWEB)

    Wild, C.; Wauer, A. (comps.)

    2001-07-01

    The Bavarian State Institute of Forestry (LWF) organised a 'Fuel Wood Symposium' in Freising-Weihenstephan on 17.11.2000. The purpose of this specialist conference was to give an overview of the use of biomass, especially wood, as an source of energy. (orig.) [German] Die Bayerische Landesanstalt fuer Wald und Forstwirtschaft richtete am 17.11.2000 in Freising-Weihenstephan das 'Symposium Energieholz' aus. Ziel der Fachtagung war es, einen Ueberblick ueber die energetische Nutzung von Biomasse, insbesondere Holz, zu geben. (orig.)

  13. India Symposium

    Indian Academy of Sciences (India)

    JNCASR

    The panel discussion is scheduled in the pre lunch session of the. India Symposium ... School of Life Sciences, Jawaharlal Nehru University,. New Delhi. 5. ... (1) Showcasing the work done by Indian Women Scientists. (2) Panel Discussion on Gender Issues in Indian Science. Program: 09.00 a.m. – 09.10 a.m.. : Welcome ...

  14. 78 FR 45061 - Safety Zone; Sister Bay Marina Fest Fireworks and Ski Show, Sister Bay, WI

    Science.gov (United States)

    2013-07-26

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Sister Bay Marina Fest Fireworks and Ski... intended to restrict vessels from a portion of Sister Bay due to a fireworks display and ski show. This... with the fireworks display and ski show in Sister Bay on August 31, 2013. DATES: This rule is effective...

  15. Symposium Highlights

    International Nuclear Information System (INIS)

    Owen-Whitred, K.

    2015-01-01

    Overview/Highlights: To begin, I'd like to take a moment to highlight some of the novel elements of this Symposium as compared to those that have been held in the past. For the first time ever, this Symposium was organized around five concurrent sessions, covering over 300 papers and presentations. These sessions were complemented by an active series of exhibits put on by vendors, universities, ESARDA, INMM, and Member State Support Programmes. We also had live demonstrations throughout the week on everything from software to destructive analysis to instrumentation, which provided the participants the opportunity to see recent developments that are ready for implementation. I'm sure you all had a chance to observe - and, more importantly, interact with - the electronic Poster, or ePoster format used this past week. This technology was used here for the first time ever by the IAEA, and I'm sure was a first for many of us as well. The ePoster format allowed participants to interact with the subject matter, and the subject matter experts, in a dynamic, engaging way. In addition to the novel technology used here, I have to say that having the posters strategically embedded in the sessions on the same topic, by having each poster author introduce his or her topic to the assembled group in order to lure us to the poster area during the breaks, was also a novel and highly effective technique. A final highlight I'd like to touch on in terms of the Symposium organization is the diversity of participation. This chart shows the breakdown by geographical distribution for the Symposium, in terms of participants. There are no labels, so don't try to read any, I simply wanted to demonstrate that we had great representation in terms of both the Symposium participants in general and the session chairs more specifically-and on that note, I would just mention here that 59 Member States participated in the Symposium. But what I find especially interesting and

  16. IUTAM Symposium

    CERN Document Server

    Stefanou, George

    2014-01-01

    This book contains the proceedings of the IUTAM Symposium on Multiscale Modeling and Uncertainty Quantification of Materials and Structures that was held at Santorini, Greece, September 9 – 11, 2013. It consists of 20 chapters which are divided in five thematic topics: Damage and fracture, homogenization, inverse problems–identification, multiscale stochastic mechanics and stochastic dynamics. Over the last few years, the intense research activity at microscale and nanoscale reflected the need to account for disparate levels of uncertainty from various sources and across scales. As even over-refined deterministic approaches are not able to account for this issue, an efficient blending of stochastic and multiscale methodologies is required to provide a rational framework for the analysis and design of materials and structures. The purpose of this IUTAM Symposium was to promote achievements in uncertainty quantification combined with multiscale modeling and to encourage research and development in this grow...

  17. India Symposium

    Indian Academy of Sciences (India)

    JNCASR

    Science and a few young women scientists as well who will give a perception of those who are entering the field now. The panel discussion is scheduled in the pre lunch session of the. India Symposium which will start at 9.00 a.m. We envisage a talk by each panelist for about 5-7 minutes, followed by a discussion and then ...

  18. IUTAM Symposium

    CERN Document Server

    Shioiri, Jumpei

    1996-01-01

    The IUTAM Symposium on Constitutive Relation in High/Very High Strain Rates (CRHVHSR) was held October 16 - 19, 1995, at Seminar House, Science University of Tokyo, under the sponsorship of IUTAM, Japan Society for the Promotion of Science, The Commemorative Association for the Japan World Exposition (1970), Inoue Foundation for Science, The Japan Society for Aeronautical and Space Sciences, and Science University of Tokyo. The proposal to hold the symposium was accepted by the General Assembly of IUT AM held in Haifa, Israel, in August 1992, and the scientists mentioned below were appointed by the Bureau of IUTAM to serve as members of the Scientific Committee. The main object of the symposium was to make a general survey of recent developments in the research of constitutive relations in high and very high strain rates and related problems in high velocity solid mechanics, and to explore further new ideas for dealing with unresolved problems of a fundamental nature as well as of practical importance. The su...

  19. Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalities

    Directory of Open Access Journals (Sweden)

    Jessica Patel

    2016-02-01

    Full Text Available The first meiotic division in human oocytes is highly error-prone and contributes to the uniquely high incidence of aneuploidy observed in human pregnancies. A successful meiosis I (MI division entails separation of homologous chromosome pairs and co-segregation of sister chromatids. For this to happen, sister kinetochores must form attachments to spindle kinetochore-fibres emanating from the same pole. In mouse and budding yeast, sister kinetochores remain closely associated with each other during MI, enabling them to act as a single unified structure. However, whether this arrangement also applies in human meiosis I oocytes was unclear. In this study, we perform high-resolution imaging of over 1900 kinetochores in human oocytes, to examine the geometry and architecture of the human meiotic kinetochore. We reveal that sister kinetochores in MI are not physically fused, and instead individual kinetochores within a pair are capable of forming independent attachments to spindle k-fibres. Notably, with increasing female age, the separation between kinetochores increases, suggesting a degradation of centromeric cohesion and/or changes in kinetochore architecture. Our data suggest that the differential arrangement of sister kinetochores and dual k-fibre attachments may explain the high proportion of unstable attachments that form in MI and thus indicate why human oocytes are prone to aneuploidy, particularly with increasing maternal age.

  20. Symposium Summary

    Science.gov (United States)

    Levesque, Emily M.

    2017-11-01

    This proceeding summarizes the highlights of IAU 329, ``The Lives and Death-Throes of Massive Stars'', held in Auckland, NZ from 28 Nov - 2 Dec. I consider the progress that has been made in the field over the course of these ``beach symposia'', outline the overall content of the conference, and discuss how the current subfields in massive stellar astrophysics have evolved in recent years. I summarize some of the new results and innovative approaches that were presented during the symposium, and conclude with a discussion of how current and future resources in astronomy can serve as valuable tools for studying massive stars in the coming years.

  1. Biotechnology Symposium

    Science.gov (United States)

    1990-10-01

    in both the plant and animal world; and chemical de- tection at a threshold as sensitive as ten molecules of sex attractant by the cockroach . In...34 J. Biomedical Material Research Symposium, Vol. 1, 1971, pp. 225-235. 4. Bradley, J.S. and Hastings, G.W., "Carbon F’ber Reinforced Plastics for...on the Compressive and Short Beam Shear Properties of Fiberite T300/976 Fabric," J_ Reinforced Plastics and Composites. Vol. 7, 1988, 120-135. 18

  2. [Two Dutch sisters in analysis with Freud].

    Science.gov (United States)

    Stroeken, Harry

    2010-01-01

    The author provides persuasive or at least plausible data for the identity of two patients recorded by Freud in his working season of 1910/11. They were two sisters, living in The Hague/Leiden, who came from a rich banker's family, the van der Lindens. Whereas the treatment does not seem to have led to any decisive improvement for the older of the two, it may have encouraged the younger sister to seek divorce.

  3. IUTAM Symposium

    CERN Document Server

    Pedley, Timothy

    2003-01-01

    The IUTAM Symposium on Flow in Collapsible Tubes and Past Other Highly Compliant Boundaries was held on 26-30 March, 2001, at the University of Warwick. As this was the first scientific meeting of its kind we considered it important to mark the occasion by producing a book. Accordingly, at the end of the Symposium the Scientific Committee met to discuss the most appropriate format for the book. We wished to avoid the format of the conventional conference book consisting of a large number of short articles of varying quality. It was agreed that instead we should produce a limited number of rigorously refereed and edited articles by selected participants who would aim to sum up the state of the art in their particular research area. The outcome is the present book. Peter W. Ca rpenter, Warwick Timothy J. Pedley, Cambridge May, 2002. VB SCIENTIFIC COMMITTEE Co-Chair: P.W. Carpenter, Engineering, Warwiek, UK Co-Chair: TJ. Pedley, DAMTP, Cambridge, UK V.V. Babenko, Hydromechanics, Kiev, Ukraine R. Bannasch, Bionik...

  4. SPPEXA Symposium

    CERN Document Server

    Neumann, Philipp; Nagel, Wolfgang

    2016-01-01

    The research and its outcomes presented in this collection focus on various aspects of high-performance computing (HPC) software and its development which is confronted with various challenges as today's supercomputer technology heads towards exascale computing. The individual chapters address one or more of the research directions (1) computational algorithms, (2) system software, (3) application software, (4) data management and exploration, (5) programming, and (6) software tools. The collection thereby highlights pioneering research findings as well as innovative concepts in exascale software development that have been conducted under the umbrella of the priority programme "Software for Exascale Computing" (SPPEXA) of the German Research Foundation (DFG) and that have been presented at the SPPEXA Symposium, Jan 25-27 2016, in Munich. The book has an interdisciplinary appeal: scholars from computational sub-fields in computer science, mathematics, physics, or engineering will find it of particular interest...

  5. IUTAM Symposium

    CERN Document Server

    Bui, Huy

    1993-01-01

    Inverse problems occur in a wide variey of fields. In general, the inverse problem can be defined as one where one should estimate the cause from the result, while the direct problem is concerned with how to obtain the result from the cause. The aim of this symposium was to gather scientists and researchers in engineering mechanics concerned with inverse problems in order to exchange research result and develop computational and experimentalapproaches to solve inverse problems. The contributions in this volume cover the following subjects: mathematical and computational aspects of inverse problems, parameter or system identification, shape determination, sensitivity analysis, optimization, material property characterization, ultrasonic nondestructive testing, elastodynamic inverse problems, thermal inverse problems, and other miscellaneous engineering applications.

  6. Seventh International Beaver Symposium

    OpenAIRE

    Yuri A. Gorshkov

    2016-01-01

    The paper presents data on the seventh international Beaver Symposium. Brief historical background about previous Beaver Symposia beaver is shown. Data on the sections of symposium, number of participants and reports are presented.

  7. Seventh International Beaver Symposium

    Directory of Open Access Journals (Sweden)

    Yuri A. Gorshkov

    2016-05-01

    Full Text Available The paper presents data on the seventh international Beaver Symposium. Brief historical background about previous Beaver Symposia beaver is shown. Data on the sections of symposium, number of participants and reports are presented.

  8. Identical Twin Primigravid Sisters -Spontaneous Labour and ...

    African Journals Online (AJOL)

    We report 2 cases of identical twin sisters, the older sibling getting married 14 months earlier but both got pregnant for their first child at about the same time and were managed by the same Obstetrician and fell into spontaneous labour within a few hours of each other. Both were delivered by emergency caesarean section ...

  9. Sisters Hope - Protected by the Fiction

    DEFF Research Database (Denmark)

    Lawaetz, Anna; Hallberg, Gry Worre

    2011-01-01

    In this article we will introduce the fictional and art-pedagogical universe of Sisters Hope and describe how it in different ways transcends into contexts beyond the art world and thus functions as a tool to democratize the aesthetic dimension and mode of being within high schools, academia...

  10. Sister-to-sister oocyte donation: couples’ experiences with regard to genetic ties

    OpenAIRE

    WYVERKENS, ELIA; Van Parys, Hanna; Provoost, Veerle; Pennings, Guido; De Sutter, Petra; Buysse, Ann

    2016-01-01

    Objective: This study aimed to gain an in-depth understanding of the experiences of genetic ties in intrafamily oocyte donation families. Background: Previous research has shown that most mothers have a good and stable relationship with their donor. Little is known about the meaning of the difference in genetic ties for parents who conceived through sister-to-sister oocyte donation. Methods: An Interpretative Phenomenological Analysis was performed and focused on both individual experie...

  11. 4th Abel Symposium

    CERN Document Server

    Friedlander, Eric; Jahren, Björn; Østvær, Paul

    2009-01-01

    The 2007 Abel Symposium took place at the University of Oslo in August 2007. The goal of the symposium was to bring together mathematicians whose research efforts have led to recent advances in algebraic geometry, algebraic K-theory, algebraic topology, and mathematical physics. A common theme of this symposium was the development of new perspectives and new constructions with a categorical flavor. As the lectures at the symposium and the papers of this volume demonstrate, these perspectives and constructions have enabled a broadening of vistas, a synergy between once-differentiated subjects, and solutions to mathematical problems both old and new.

  12. Flight Mechanics Symposium 1997

    Science.gov (United States)

    Walls, Donna M. (Editor)

    1997-01-01

    This conference publication includes papers and abstracts presented at the Flight Mechanics Symposium. This symposium featured technical papers on a wide range of issues related to orbit-attitude prediction, determination, and control; attitude sensor calibration; attitude determination error analysis; attitude dynamics; and orbit decay and maneuver strategy. Government, industry, and the academic community participated in the preparation and presentation of these papers.

  13. The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion

    OpenAIRE

    Kim, Hyun-Soo; Baek, Kwan-Hyuck; Ha, Geun-Hyoung; Lee, Jae-Chul; Kim, Yu-Na; Lee, Janet; Park, Hye-Young; Lee, Noo Ri; Lee, Ho; Cho, Yunje; Lee, Chang-Woo

    2010-01-01

    An interplay of phosphorylation, dephosphorylation and protecting factors controls proteolysis-independent cohesin dissociation from chromosomes. The identification of a new phosphatase protecting arm cohesin now adds further complexity to this regulation.

  14. β -carotene effect the induction of the sister chromatid exchanges (ICH) by gamma radiation in mouse radiosensibilized osseous marrow cells In vivo

    International Nuclear Information System (INIS)

    Morales R, P.; Cruz V, V.L.

    1997-01-01

    The effect of β- carotene over the ICH radioinduction in radiosensibilized with BrdU osseous marrow cells of mouse was determined In vivo. The treatment with 50 μg β carotene per se induces a significant increment in the ICH frequency and the pre or post-treatment with the same dose causes an additive effect in the ICH frequency produced by 0.62 Gy of gamma radiation. This implies that β- carotene does not have radioprotective activity, under conditions which was developed this experiment. (Author)

  15. Two Sisters with Idiopathic Pulmonary Hemosiderosis

    Directory of Open Access Journals (Sweden)

    Mehmet Gencer

    2007-01-01

    Full Text Available Idiopathic pulmonary hemosiderosis (IPH is a rare cause of diffuse alveolar hemorrhage with unknown etiology. In the present report, the presentations of two sisters are described: one sister had IPH, eosinophilia and a high serum immunoglobulin E (IgE level; and the other had IPH, pneumothorax, eosinophilia and a high serum IgE level. Both cases had quite unusual presentations. The first patient was 23 years of age, and had suffered from dry cough and progressive dyspnea for four years. Her hemoglobin level was 60 g/L, total serum IgE level was 900 U/mL and eosinophilia was 9%. Her chest radiography revealed diffuse infiltration. She died due to respiratory failure. The second patient was 18 years of age. She had also suffered from dry cough and gradually increasing dyspnea for two years. She had partial pneumothorax in the right lung and diffuse infiltration in other pulmonary fields on chest radiography. Her hemoglobin level was 99 g/L, total serum IgE level was 1200 U/mL and eosinophilia was 8%. IPH was diagnosed by open lung biopsy. All these findings suggested that familial or allergic factors, as well as immunological factors, might have contributed to the etiology of IPH.

  16. Two sisters with idiopathic pulmonary hemosiderosis

    Science.gov (United States)

    Gencer, Mehmet; Ceylan, Erkan; Bitiren, Muharrem; Koc, Ahmet

    2007-01-01

    Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of diffuse alveolar hemorrhage with unknown etiology. In the present report, the presentations of two sisters are described: one sister had IPH, eosinophilia and a high serum immunoglobulin E (IgE) level; and the other had IPH, pneumothorax, eosinophilia and a high serum IgE level. Both cases had quite unusual presentations. The first patient was 23 years of age, and had suffered from dry cough and progressive dyspnea for four years. Her hemoglobin level was 60 g/L, total serum IgE level was 900 U/mL and eosinophilia was 9%. Her chest radiography revealed diffuse infiltration. She died due to respiratory failure. The second patient was 18 years of age. She had also suffered from dry cough and gradually increasing dyspnea for two years. She had partial pneumothorax in the right lung and diffuse infiltration in other pulmonary fields on chest radiography. Her hemoglobin level was 99 g/L, total serum IgE level was 1200 U/mL and eosinophilia was 8%. IPH was diagnosed by open lung biopsy. All these findings suggested that familial or allergic factors, as well as immunological factors, might have contributed to the etiology of IPH. PMID:18060095

  17. Three Sisters Dam: Investigations and monitoring

    International Nuclear Information System (INIS)

    Slopek, R.J.; Courage, L.J.R.; Keys, R.A.

    1990-01-01

    The geotechnical investigations, monitoring and interpretation of data associated with the evaluation of the Three Sisters Dam, which has been suffering from excessive seepage and is in need of enhancement, are outlined. The Three Sisters Dam is located in the continental ranges of the Rocky Mountains in Alberta, impounding the Spray Reservoir, and is founded on 60 m of interbedded sand, gravel, silt and clay layers. The computer code PC-SEEP was used to evaluate seepage. Details are provided of drilling, ground-penetrating radar surveys, seismic surveys, penstock inspection, sinkhole activity, piezometer monitoring, silt wells, settlement monuments, and tailrace monitoring. The intensive investigations of the foundations showed that they consist of a complex formation of interfingered stratified layers and leases of talus and glaciofluvial deposits. Due to the depth and nature of these materials drill hole penetration was limited to the use of the Becker hammer. This equipment successfully delineated the major soil horizons of the foundation. The continued information attained from inspection, drilling, testing, radar surveys, seismic work, monitoring of piezometers, leakage, silt wells and settlement monuments indicated that there are no large voids within the foundation of the dam. 2 refs., 12 figs

  18. CONTEXT 2015 Doctorial Symposium

    DEFF Research Database (Denmark)

    Eklund, Peter; wegener, rebekah

    2015-01-01

    What is the CONTEXT 2015 Doctoral Symposium? The CONTEXT 2015 Doctoral Symposium is an opportunity for doctoral researchers to showcase their work and discuss problems, challenges, and ideas in an open and collegial environment with expert feedback. The Doctoral Symposium is a workshop for doctoral...... feedback and general advice in a constructive atmosphere. Doctoral researchers will present and discuss their research in a supportive atmosphere with other doctoral researchers and an international panel of established researchers that provide expert feedback. The workshop will take place on a single full...... day, Monday November 2, 2015, the day prior to the start of the main CONTEXT 2015 conference....

  19. EarthLabs Meet Sister Corita Kent

    Science.gov (United States)

    Quartini, E.; Ellins, K. K.; Cavitte, M. G.; Thirumalai, K.; Ledley, T. S.; Haddad, N.; Lynds, S. E.

    2013-12-01

    The EarthLabs project provides a framework to enhance high school students' climate literacy and awareness of climate change. The project provides climate science curriculum and teacher professional development, followed by research on students' learning as teachers implement EarthLabs climate modules in the classroom. The professional development targets high school teachers whose professional growth is structured around exposure to current climate science research, data observation collection and analysis. During summer workshops in Texas and Mississippi, teachers work through the laboratories, experiments, and hand-on activities developed for their students. In summer 2013, three graduate students from the University of Texas at Austin Institute for Geophysics with expertise in climate science participated in two weeklong workshops. The graduate students partnered with exemplary teacher leaders to provide scientific content and lead the EarthLabs learning activities. As an experiment, we integrated a visit to the Blanton Museum and an associated activity in order to motivate participants to think creatively, as well as analytically, about science. This exercise was inspired by the work and educational philosophy of Sister Corita Kent. During the visit to the Blanton Museum, we steered participants towards specific works of art pre-selected to emphasize aspects of the climate of Texas and to draw participants' attention to ways in which artists convey different concepts. For example, artists use of color, lines, and symbols conjure emotional responses to imagery in the viewer. The second part of the exercise asked participants to choose a climate message and to convey this through a collage. We encouraged participants to combine their experience at the museum with examples of Sister Corita Kent's artwork. We gave them simple guidelines for the project based on techniques and teaching of Sister Corita Kent. Evaluation results reveal that participants enjoyed the

  20. COST 516 Tribology Symposium

    Energy Technology Data Exchange (ETDEWEB)

    Ronkainen, H.; Holmberg, K. [eds.

    1998-11-01

    Cost 516 Tribology action is the first joint European research action focusing on tribology, which originates in the approval of its Memorandum of understanding in February 1994. The COST 516 Tribology Symposium took place in Espoo, Finland from 14th to 15th May 1998. This was the first Symposium of the COST 516 Tribology action. The large number of research contributions at the Symposium, altogether almost SO, and their scientific and technical level, is an indication of the importance and significance of tribology research. The symposium proceedings contain papers in a wide variety of subjects, covering the three categories of the COST 516 Tribology action, namely Grease lubrication (GRIT), Tribology of renewable environmentally adapted lubricants (REAL) and Coatings and surface treatments (CAST). (orig.)

  1. 1999 Flight Mechanics Symposium

    Science.gov (United States)

    Lynch, John P. (Editor)

    1999-01-01

    This conference publication includes papers and abstracts presented at the Flight Mechanics Symposium held on May 18-20, 1999. Sponsored by the Guidance, Navigation and Control Center of Goddard Space Flight Center, this symposium featured technical papers on a wide range of issues related to orbit-attitude prediction, determination, and control; attitude sensor calibration; attitude determination error analysis; attitude dynamics; and orbit decay and maneuver strategy. Government, industry, and the academic community participated in the preparation and presentation of these papers.

  2. An Amazonia Symposium: Mixed Perspectives

    Science.gov (United States)

    Huerta, Gloria; Shand, Hope

    1978-01-01

    Reporting on the second symposium on "Amazonia: Extinction or Survival" (Madison, Wisconsin, 1978), this article summarizes papers presented on colonization, health, education, law, etc., and presents the symposium's six resolutions. (JC)

  3. Are there sister trajectories in the Veneziano model

    International Nuclear Information System (INIS)

    Kudryavtsev, V.A.

    1978-01-01

    The problem of existence of ''sister'' trajectories in the Veneziano dual model is considered. It is shown that the arguments by Hoyer, Toernquist, Webber in favour of a contribution from a ''sister'' trajectory with a slope, equal to half of that for the usual Regge trajectory, to asymptotics of the six-particle Veneziano amplitude, have no foundation

  4. Uncoupling of Sister Replisomes during Eukaryotic DNA Replication

    NARCIS (Netherlands)

    Yardimci, Hasan; Loveland, Anna B.; Habuchi, Satoshi; van Oijen, Antoine M.; Walter, Johannes C.

    2010-01-01

    The duplication of eukaryotic genomes involves the replication of DNA from multiple origins of replication. In S phase, two sister replisomes assemble at each active origin, and they replicate DNA in opposite directions. Little is known about the functional relationship between sister replisomes.

  5. Creating Sister Cities: An Exchange Across Hemispheres

    Science.gov (United States)

    Adams, M. T.; Cabezon, S. A.; Hardy, E.; Harrison, R. J.

    2008-06-01

    Sponsored by Associated Universities, Inc. (AUI) and the National Radio Astronomy Observatory (NRAO), this project creates a cultural and educational exchange program between communities in South and North America, linking San Pedro de Atacama in Chile and Magdalena, New Mexico in the United States. Both communities have similar demographics, are in relatively undeveloped regions of high-elevation desert, and are located near major international radio astronomy research facilities. The Atacama Large Millimeter/submillimeter Array (ALMA) is just 40 km east of San Pedro; the Very Large Array (VLA) is just 40 km west of Magdalena. In February 2007, the Mayor of San Pedro and two teachers visited Magdalena for two weeks; in July 2007 three teachers from Magdalena will visit San Pedro. These visits enable the communities to lay the foundation for a permanent, unique partnership. The teachers are sharing expertise and teaching methodologies for physics and astronomy. In addition to creating science education opportunities, this project offers students linguistic and cultural connections. The town of San Pedro, Chile, hosts nearly 100,000 tourists per year, and English language skills are highly valued by local students. Through exchanges enabled by email and distance conferencing, San Pedro and Magdalena students will improve English and Spanish language skills while teaching each other about science and their respective cultures. This poster describes the AUI/NRAO Sister Cities program, including the challenges of cross-cultural communication and the rewards of interpersonal exchanges between continents and cultures.

  6. Sister Cities and Economic Development: A New Zeeland Perspective

    Directory of Open Access Journals (Sweden)

    Brian CROSS

    2010-06-01

    Full Text Available Sister City relationships, originally built on cultural understanding and peace through citizen diplomacy, are evolving in today’s society. Politicians increasingly demand real returns where local government is actively involved. Meaningful sister city links are an asset for any community and its nation. However full utilisation requires skills and commitment talked about but often lacking in delivery. Increased emphasis on economic development as primary motivator for having sister cities provides opportunities, but also presents risks as policy emphasis shifts from relationship-building to pragmatic, shorter term goals. New Zealand’s portfolio of sister cities reflect its place on the Pacific Rim and its political/ economic positioning as “part of Asia”. An upsurge in interest from and in China as the place to do business has coincided with a levelling off of sister city activities when they should be increasing. The reasons are varied, but demonstrate the challenges New Zealand faces in continuing as a front-runner in the sister city movement. Sister city policies require honest assessment. Limited resources demand better investment where opportunities are identified or disassociation where they are not. Success requires robust policy development, professionalism and an effective public relations campaign informing communities concerned of the possibilities their international links can present.

  7. Abel Symposium 2015

    CERN Document Server

    Larsen, Nadia; Neshveyev, Sergey; Skau, Christian

    2016-01-01

    Like the first Abel Symposium, held in 2004, the Abel Symposium 2015 focused on operator algebras. It is interesting to see the remarkable advances that have been made in operator algebras over these years, which strikingly illustrate the vitality of the field. A total of 26 talks were given at the symposium on a variety of themes, all highlighting the richness of the subject. The field of operator algebras was created in the 1930s and was motivated by problems of quantum mechanics. It has subsequently developed well beyond its initial intended realm of applications and expanded into such diverse areas of mathematics as representation theory, dynamical systems, differential geometry, number theory and quantum algebra. One branch, known as “noncommutative geometry”, has become a powerful tool for studying phenomena that are beyond the reach of classical analysis. This volume includes research papers that present new results, surveys that discuss the development of a specific line of research, and articles ...

  8. Familial hypomagnesemia with hypercaliuria and nephrocalcinosis in 2 sisters

    International Nuclear Information System (INIS)

    Al-Elq, Abdulmohsen H.

    2008-01-01

    Familial hypomagnesemia with hypercaliuria and nephrocalcinosis (FHHNC) is a rare autosomal recessive tubular disorder characterized by excessive renal magnesium and calcium wasting, eventually, progressing to renal failure. It has been recently attributed to a mutation in the Claudin 16 (CLDN 16) gene of the Paracellin-1 (PCLN-1) tight junction protein. Herein, we report 2 sisters with FHHNC. Both sisters presented at an early stage with hypomagnesemia and hypocalcemia. The first patient was initially mislabeled and treated as a case of hypoparathyroidism, while the second patient was diagnosed retrospectively after the diagnosis of her sister. The 2 patients developed end stage renal disease. (author)

  9. The Abel Symposium 2013

    CERN Document Server

    Irgens, Marius; Wold, Erlend

    2015-01-01

    This book focuses on complex geometry and covers highly active topics centered around geometric problems in several complex variables and complex dynamics, written by some of the world’s leading experts in their respective fields. This book features research and expository contributions from the 2013 Abel Symposium, held at the Norwegian University of Science and Technology Trondheim on July 2-5, 2013. The purpose of the symposium was to present the state of the art on the topics, and to discuss future research directions.

  10. 2001 Flight Mechanics Symposium

    Science.gov (United States)

    Lynch, John P. (Editor)

    2001-01-01

    This conference publication includes papers and abstracts presented at the Flight Mechanics Symposium held on June 19-21, 2001. Sponsored by the Guidance, Navigation and Control Center of Goddard Space Flight Center, this symposium featured technical papers on a wide range of issues related to attitude/orbit determination, prediction and control; attitude simulation; attitude sensor calibration; theoretical foundation of attitude computation; dynamics model improvements; autonomous navigation; constellation design and formation flying; estimation theory and computational techniques; Earth environment mission analysis and design; and, spacecraft re-entry mission design and operations.

  11. Symposium summary and prognosis

    International Nuclear Information System (INIS)

    Bjorken, J.D.

    1975-11-01

    The summary of the symposium on high energy physics experiments includes phenomena at low energies, the foundations of physics (considered to be mainly gravitation and quantum electrodynamics), standards of reference used for interpretation of experimental data, the new physics, particle proliferation, theoretical development, and a prognosis for the future

  12. Theoretical Chemistry Symposium 2006

    Indian Academy of Sciences (India)

    WINTEC

    This special issue of the Journal of Chemical Sciences contains 29 original papers presented at the Theoretical Chemistry Symposium (TCS 2006) held at Bharathi- dasan University during December 11–13, 2006. Earlier meetings on this theme were organized in various parts of the country viz. Chandigarh (1986), IIT ...

  13. European Cosmic Ray Symposium

    CERN Multimedia

    Pattison,B

    1992-01-01

    13me Symposium qui se déroule du 27 au 31 juillet pour la première fois au Cern. Brian Pattison ouvre la cérémonie et donne la parole à Dr.Ugland (qui représente le DG C.Rubbia excusé) et d'autres intervenants

  14. The Symposium's Report.

    Science.gov (United States)

    Labour Education, 1987

    1987-01-01

    Presents the report of an International Labour Office (ILO) symposium on international development and the role of workers' education. Covers the general situation, issues, role of trade unions, educational aspects of workers' involvement in development issues, and the role of the ILO. (JOW)

  15. Intervet Symposium: bovine neosporosis

    NARCIS (Netherlands)

    Schetters, T.; Dubey, J.P.; Adrianarivo, A.; Frankena, K.; Romero, J.J.; Pérez, E.; Heuer, C.; Nicholson, C.; Russell, D.; Weston, J.

    2004-01-01

    This article summarises the most relevant data of presentations delivered at the 19th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP) held in New Orleans, LA, USA, from 10 to 14 August 2003) in a symposium session on bovine neosporosis. The

  16. International symposium 'Energetics 2006'. Symposium proceedings

    International Nuclear Information System (INIS)

    2006-01-01

    ZEMAK as a civil association, created in the term positive legitimate regulations of our country, presents non party, non political and non profitable association, which primary goal is animation of eperts and other scientific and non scientific workers in the function of permanent following, studying and giving directives for solve the energy problems for a long temporal period. Behind us are fourteen successful years of fertile and wealthy work, which is bringing maimal penetration in domestic as well as foreign scientific field. This successful work of ZEMAK deserves by all members which professional work is in the institutions like: MANU (Macedonian academy of science and art), Technical faculties from the Universities, state and private company from energy field and other civil persons. The main goal of this 9-th International Symposium traditionally is to collect all engineers and eperts from the field of energy, and those which professional life is energy. During this International Symposium will be present, analyze and discuss about 100 incoming papers, prepared by 100th or more authors and coauthors, divided in the following topics: Basic energy and ecology, Renewable energy sources, Energy efficiency and energy saving and Management in energy and regulations.

  17. Organization of Sisters of Mercy During World War One

    Directory of Open Access Journals (Sweden)

    Sribnaia Anna

    2014-10-01

    Full Text Available The article examines the labour organization of Russian sisters of mercy during World War One. The author indicates two periods which took place before and after the February Revolution. Based on archive documents and offi cial publications the article describes general structure of Russian Red Cross Society institutions and basic principles of sisters of mercy communities’ work. It examines the rules of new sisters’ employment, their training, service assignment and professional duties. The emphasis is put on nurses’ work in wartime. During first years of war sisters’ position was stable. Due to specifi c hierarchy in the managing structure sisters’ work was productive and demanded. After the February Revolution the managing system changed drastically as well as the status of sisters of mercy and their reception in society. The author gives a thorough examination of sisters’ position after reorganization of Russian Red Cross Society. In time of political instability Russian sisters of mercy were able to organize themselves into one big organization thus creating All-Russian Union of Sisters of Mercy. This article for the first time ever implements into scientific research a huge amount of documents which allowed a signifi cant extension of views on Bolsheviks’ political approaches to Russian Red Cross Society and institution of sisters of mercy.

  18. Fourth Tennessee water resources symposium

    International Nuclear Information System (INIS)

    Sale, M.J.; Presley, P.M.

    1991-01-01

    The annual Tennessee Water Resources Symposium was initiated in 1988 as a means to bring together people with common interests in the state's important water-related resources at a technical, professional level. Initially the symposium was sponsored by the American Institute of Hydrology and called the Hydrology Symposium, but the Tennessee Section of the American Water Resources Association (AWRA) has taken on the primary coordination role for the symposium over the last two years and the symposium name was changed in 1990 to water resources to emphasize a more inter-disciplinary theme. This year's symposium carries on the successful tradition of the last three years. Our goal is to promote communication and cooperation among Tennessee's water resources professionals: scientists, engineers, and researchers from federal, state, academic, and private institutions and organizations who have interests and responsibilities for the state's water resources. For these conference proceedings, individual papers are processed separately for the Energy Data Base

  19. Extended summary of the symposium

    International Nuclear Information System (INIS)

    Vincent, C.; Labalettet, T.; Cahen, B.; Voinis, S.; Griffault, L.; Bodenez, P.; Pescatore, C.; Metcalf, P.; Monig, J.; Marivoet, J.; Alonso, J.; Ferch, R.; Zuidema, P.; Schneider, J.; Gitlin, B.; Andersson, J.; Goldsworthy, M.; Molnar, P.; Danko, G.; Nagy, Z.; Frigyesi, F.; Leung, H.; Gierszewski, P.; Kempe, T.; Heystee, R.; Jensen, M.; Bailey, L.E.F.

    2008-01-01

    For each symposium session, a synopsis of the presentations and highlights of any following discussion are presented below. The synopses are based on the contents of presentations and on rapporteur reports prepared on each session in co-operation with the session chairperson. The symposium consisted of four main presentation and discussion sessions, one poster session, a fifth session to summarize the symposium, and closing remarks by the three sponsoring international agencies. (author)

  20. Biomonitoring of genotoxic risk in radar facility workers: comparison of the comet assay with micronucleus assay and chromatid breakage assay

    International Nuclear Information System (INIS)

    Garaj-Vrhovac, V.; Kopjar, N.

    2003-01-01

    Genotoxic risks of occupational exposure in a radar facility were evaluated by using alkaline comet assay, micronucleus assay and chromatid breakage assay on peripheral blood leukocytes in exposed subjects and corresponding controls. Results show that occupational exposure to microwave radiation correlates with an increase of genome damage in somatic cells. The levels of DNA damage in exposed subjects determined by using alkaline comet assay were increased compared to control and showed interindividual variations. Incidence of micronuclei was also significantly increased compared to baseline control values. After short exposure of cultured lymphocytes to bleomycin, cells of occupationally exposed subjects responded with high numbers of chromatid breaks. Although the level of chromosome damage generated by bleomycin varied greatly between individuals, in exposed subjects a significantly elevated number of chromatid breaks was observed. Our results support data reported in literature indicating that microwave radiation represents a potential DNA-damaging hazard. Alkaline comet assay is confirmed as a sensitive and highly reproducible technique for detection of primary DNA damage inflicted in somatic cells. Micronucleus assay was confirmed as reliable bio-markers of effect and chromatid breakage assay as sensitive bio-marker of individual cancer susceptibility. The results obtained also confirm the necessity to improve measures and to perform accurate health surveillance of individuals occupationally exposed to microwave radiation

  1. International RILEM Symposium

    CERN Document Server

    Birgisson, Björn; Frost, David; Wang, Linbing

    2013-01-01

    The micro- and nano-modification of infrastructure materials and the associated multi-scale characterization and simulation has the potential to open up whole new uses and classes of materials, with wide-ranging implications for society. The use of multi-scale characterization and simulation brings the ability to target changes at the very small scale that predictably effect the bulk behavior of the material and thus allowing for the optimization of material behavior and performance.   The International RILEM Symposium on Multi-Scale Modeling and Characterization of Infrastructure Materials (Stockholm, June 10-12, 2013) brought together key researchers from around the world to present their findings and ongoing research in this field in a focused environment with extended discussion times. From asphalt to concrete, from chemistry to mechanics, from nano- to macro-scale: the collection of topics covered by the Symposium represents the width and depth of the currently ongoing efforts of developing more sustain...

  2. Symposium 2 of JENAM

    CERN Document Server

    Pasquali, Anna; Environment and the Formation of Galaxies : 30 years later

    2011-01-01

    The publication of the morphology - density relation by Alan Dressler in 1980 brought into the limelight the role played by environment in the formation and evolution of galaxies. The symposium Environment and the Formation of Galaxies: 30 years later, was organised with the purpose of establishing the environmental impact on the evolution of galaxies and its dependence on look-back time. Special emphasis was placed on the physical mechanisms that are responsible for transforming galaxies once they are accreted by a group or a cluster, including the observable imprint left in the galaxy HI distribution. Other major topics of the symposium were the environmental dependence of galaxy properties at z ≥ 1 and the implementation of environmental effects in cosmological models of galaxy formation and evolution. This book presents the edited proceedings of this stimulating meeting.

  3. The Abel Symposium 2012

    CERN Document Server

    Lyubarskii, Yurii; Seip, Kristian

    2015-01-01

    This book collects the proceedings of the 2012 Abel Symposium, held at the Norwegian Academy of Science and Letters, Oslo. The Symposium, and this book, are focused on two important fields of modern mathematical analysis: operator-related function theory and time-frequency analysis; and the profound interplay between them. Among the original contributions and overview lectures gathered here are a paper presenting multifractal analysis as a bridge between geometric measure theory and signal processing; local and global geometry of Prony systems and Fourier reconstruction of piecewise-smooth functions;  Bernstein's problem on weighted polynomial approximation; singular distributions and symmetry of the spectrum; and many others. Offering a selection of the latest and most exciting results obtained by world-leading researchers, the book will benefit scientists working in Harmonic and Complex Analysis, Mathematical Physics and Signal Processing.

  4. 1979 DOE statistical symposium

    International Nuclear Information System (INIS)

    Gardiner, D.A.; Truett, T.

    1980-09-01

    The 1979 DOE Statistical Symposium was the fifth in the series of annual symposia designed to bring together statisticians and other interested parties who are actively engaged in helping to solve the nation's energy problems. The program included presentations of technical papers centered around exploration and disposal of nuclear fuel, general energy-related topics, and health-related issues, and workshops on model evaluation, risk analysis, analysis of large data sets, and resource estimation

  5. Space 2000 Symposium

    Science.gov (United States)

    1999-01-01

    The purpose of the Space 2000 Symposium is to present the creativity and achievements of key figures of the 20th century. It offers a retrospective discussion on space exploration. It considers the future of the enterprise, and the legacy that will be left for future generations. The symposium includes panel discussions, smaller session meetings with some panelists, exhibits, and displays. The first session entitled "From Science Fiction to Science Facts" commences after a brief overview of the symposium. The panel discussions include talks on space exploration over many decades, and the missions of the millennium to search for life on Mars. The second session, "Risks and Rewards of Human Space Exploration," focuses on the training and health risks that astronauts face on their exploratory mission to space. Session three, "Messages and Messengers Informing and Inspire Space Exploration and the Public," focuses on the use of TV medium by educators and actors to inform and inspire a wide variety of audiences with adventures of space exploration. Session four, "The Legacy of Carl Sagan," discusses the influences made by Sagan to scientific research and the general public. In session five, "Space Exploration for a new Generation," two student speakers and the NASA Administrator Daniel S. Goldin address the group. Session six, "Destiny or Delusion? -- Humankind's Place in the Cosmos," ends the symposium with issues of space exploration and some thought provoking questions. Some of these issues and questions are: what will be the societal implications if we discover the origin of the universe, stars, or life; what will be the impact if scientists find clear evidence of life outside the domains of the Earth; should there be limits to what humans can or should learn; and what visionary steps should space-faring people take now for future generations.

  6. 1979 DOE statistical symposium

    Energy Technology Data Exchange (ETDEWEB)

    Gardiner, D.A.; Truett T. (comps. and eds.)

    1980-09-01

    The 1979 DOE Statistical Symposium was the fifth in the series of annual symposia designed to bring together statisticians and other interested parties who are actively engaged in helping to solve the nation's energy problems. The program included presentations of technical papers centered around exploration and disposal of nuclear fuel, general energy-related topics, and health-related issues, and workshops on model evaluation, risk analysis, analysis of large data sets, and resource estimation.

  7. UV-induced chromatid aberrations in two cell linear of Chinese hamster with different repair activity

    International Nuclear Information System (INIS)

    Ikushima, Takaji

    1978-01-01

    To elucidate the mechanism of chromosomal aberration formation, the yield and type of chromosomal aberrations induced by ultraviolet light (UV) irradiation were compared in cultured Chinese hamster cells with different repair activity. After irradiation of low fluences of UV, chromatid aberrations were produced more frequently in one cell line with impaired repair activity, B14FAF than the other showing normal DNA repair replication, CHO. There were no difference in the spectrum of the aberration types between the two. The results imply that impaired excision repair of UV-induced pyrimidine dimers or other photoproducts results in higher yield of chromosomal aberrations, and suggest the involvement of DNA repair processes in chromosomal aberration formation. (author)

  8. XV ESLAB Symposium

    CERN Document Server

    1981-01-01

    The 15th ESLAB symposium was held at the end of June 1981 in Amsterdam with the topic being X-ray astronomy. The aim of this symposium was to bring together the international astrophysical community in order to 1. review the present state of X-ray astronomy in the light of new observations gathered in recent missions and to review data on interesting objects in correlated wavelen8th regions; 2. discuss theoretical models describing the phenomena observed; 3. present ESA's European X-ray Observatory Satellite (EXOSAT) and to discuss future X-ray missions and their associated instrumenta­ tion. These topics seemed to be so interesting for the scientific community that more than 120 contributions were submitted. Of these, 94 were finally accepted and approximately 200 participants attended the 5-day meeting. The symposium was organised in nine sessions covering the whole field. Every main topic was introduced by a review lecture covering the state­ of-the-art. The aim of the meeting was to assess the impact of...

  9. Tracking chromatid segregation to identify human cardiac stem cells that regenerate extensively the infarcted myocardium.

    Science.gov (United States)

    Kajstura, Jan; Bai, Yingnan; Cappetta, Donato; Kim, Junghyun; Arranto, Christian; Sanada, Fumihiro; D'Amario, Domenico; Matsuda, Alex; Bardelli, Silvana; Ferreira-Martins, João; Hosoda, Toru; Leri, Annarosa; Rota, Marcello; Loscalzo, Joseph; Anversa, Piero

    2012-09-14

    According to the immortal DNA strand hypothesis, dividing stem cells selectively segregate chromosomes carrying the old template DNA, opposing accumulation of mutations resulting from nonrepaired replication errors and attenuating telomere shortening. Based on the premise of the immortal DNA strand hypothesis, we propose that stem cells retaining the old DNA would represent the most powerful cells for myocardial regeneration. Division of human cardiac stem cells (hCSCs) by nonrandom and random segregation of chromatids was documented by clonal assay of bromodeoxyuridine-tagged hCSCs. Additionally, their growth properties were determined by a series of in vitro and in vivo studies. We report that a small class of hCSCs retain during replication the mother DNA and generate 2 daughter cells, which carry the old and new DNA, respectively. hCSCs with immortal DNA form a pool of nonsenescent cells with longer telomeres and higher proliferative capacity. The self-renewal and long-term repopulating ability of these cells was shown in serial-transplantation assays in the infarcted heart; these cells created a chimeric organ, composed of spared rat and regenerated human cardiomyocytes and coronary vessels, leading to a remarkable restoration of cardiac structure and function. The documentation that hCSCs divide by asymmetrical and symmetrical chromatid segregation supports the view that the human heart is a self-renewing organ regulated by a compartment of resident hCSCs. The impressive recovery in ventricular hemodynamics and anatomy mediated by clonal hCSCs carrying the "mother" DNA underscores the clinical relevance of this stem cell class for the management of heart failure in humans.

  10. Teenage pregnancy: the impact of maternal adolescent childbearing and older sister's teenage pregnancy on a younger sister.

    Science.gov (United States)

    Wall-Wieler, Elizabeth; Roos, Leslie L; Nickel, Nathan C

    2016-05-25

    Risk factors for teenage pregnancy are linked to many factors, including a family history of teenage pregnancy. This research examines whether a mother's teenage childbearing or an older sister's teenage pregnancy more strongly predicts teenage pregnancy. This study used linkable administrative databases housed at the Manitoba Centre for Health Policy (MCHP). The original cohort consisted of 17,115 women born in Manitoba between April 1, 1979 and March 31, 1994, who stayed in the province until at least their 20(th) birthday, had at least one older sister, and had no missing values on key variables. Propensity score matching (1:2) was used to create balanced cohorts for two conditional logistic regression models; one examining the impact of an older sister's teenage pregnancy and the other analyzing the effect of the mother's teenage childbearing. The adjusted odds of becoming pregnant between ages 14 and 19 for teens with at least one older sister having a teenage pregnancy were 3.38 (99 % CI 2.77-4.13) times higher than for women whose older sister(s) did not have a teenage pregnancy. Teenage daughters of mothers who had their first child before age 20 had 1.57 (99 % CI 1.30-1.89) times higher odds of pregnancy than those whose mothers had their first child after age 19. Educational achievement was adjusted for in a sub-population examining the odds of pregnancy between ages 16 and 19. After this adjustment, the odds of teenage pregnancy for teens with at least one older sister who had a teenage pregnancy were reduced to 2.48 (99 % CI 2.01-3.06) and the odds of pregnancy for teen daughters of teenage mothers were reduced to 1.39 (99 % CI 1.15-1.68). Although both were significant, the relationship between an older sister's teenage pregnancy and a younger sister's teenage pregnancy is much stronger than that between a mother's teenage childbearing and a younger daughter's teenage pregnancy. This study contributes to understanding of the broader topic "who is

  11. Freud on Brothers and Sisters: A Neglected Topic

    Science.gov (United States)

    Sherwin-White, Susan

    2007-01-01

    This paper explores Freud's developing thought on brothers and sisters, and their importance in his psychoanalytical writings and clinical work. Freud's work on sibling psychology has been seriously undervalued. This paper aims to give due recognition to Freud's work in this area. (Contains 1 note.)

  12. The Lehman Sisters Hypothesis: an exploration of literature and bankers

    NARCIS (Netherlands)

    I.P. van Staveren (Irene)

    2012-01-01

    textabstractAbstract This article tests the Lehman Sisters Hypothesis in two complementary, although incomplete ways. It reviews the diverse empirical literature in behavioral, experimental, and neuroeconomics as well as related fields of behavioral research. And it presents the findings from an

  13. The Lehman Sisters Hypothesis: an exploration of literature and bankers

    NARCIS (Netherlands)

    I.P. van Staveren (Irene)

    2012-01-01

    textabstractThis article tests the Lehman Sisters Hypothesis in two complementary, although incomplete ways. It reviews the diverse empirical literature in behavioural, experimental, and neuroeconomics as well as related fields of behavioural research. And it presents the findings from an

  14. Clinical Design Sciences: A View from Sister Design Efforts.

    Science.gov (United States)

    Zaritsky, Raul; Kelly, Anthony E.; Flowers, Woodie; Rogers, Everett; O'Neill, Patrick

    2003-01-01

    Asserts that the social sciences are clinical-like endeavors, and the way that "sister" fields discover and validate their results may inform research practice in education. Describes three fields of design that confront similar societal demands for improvement (engineering product design, research on the diffusion of innovations, and…

  15. Reconstitution of Nucleosomes with Differentially Isotope-labeled Sister Histones.

    Science.gov (United States)

    Liokatis, Stamatios

    2017-03-26

    Asymmetrically modified nucleosomes contain the two copies of a histone (sister histones) decorated with distinct sets of Post-translational Modifications (PTMs). They are newly identified species with unknown means of establishment and functional implications. Current analytical methods are inadequate to detect the copy-specific occurrence of PTMs on the nucleosomal sister histones. This protocol presents a biochemical method for the in vitro reconstitution of nucleosomes containing differentially isotope-labeled sister histones. The generated complex can be also asymmetrically modified, after including a premodified histone pool during refolding of histone subcomplexes. These asymmetric nucleosome preparations can be readily reacted with histone-modifying enzymes to study modification cross-talk mechanisms imposed by the asymmetrically pre-incorporated PTM using nuclear magnetic resonance (NMR) spectroscopy. Particularly, the modification reactions in real-time can be mapped independently on the two sister histones by performing different types of NMR correlation experiments, tailored for the respective isotope type. This methodology provides the means to study crosstalk mechanisms that contribute to the formation and propagation of asymmetric PTM patterns on nucleosomal complexes.

  16. El naturalismo americano: Theodore Dreiser y Sister Carrie

    Directory of Open Access Journals (Sweden)

    Dolores G. ALONSO MULAS

    2009-08-01

    Full Text Available Para situar a un escritor, como Theodore Dreiser, y especialmente su novela Sister Carrie dentro de un movimiento literario y de una etapa determinada de la historia americana, es necesario dar un breve repaso al naturalismo, llegado a América a través de Stephen Crane

  17. Il progetto SISTER per il comune di Lignano Sabbiadoro

    Directory of Open Access Journals (Sweden)

    Alberto Poli

    2005-10-01

    Bonelli ha presentato il progetto sperimentale di sistema informatico per la gestione del territorio, che è in corso da circa un anno. Ecco la sintesi della relazione del Sistema Informativo Integrato Territoriale (SISTER realizzato da Politecnica.

  18. Sister broods in the spruce bark beetle, Ips typographus (L.)

    Czech Academy of Sciences Publication Activity Database

    Davídková, Markéta; Doležal, Petr

    2017-01-01

    Roč. 405, DEC 01 (2017), s. 13-21 ISSN 0378-1127 Grant - others:Lesy ČR(CZ) 08/2009-2015 Institutional support: RVO:60077344 Keywords : re-emergence * sister broods * Ips typographus Subject RIV: EH - Ecology, Behaviour OBOR OECD: Zoology Impact factor: 3.064, year: 2016 http://www.sciencedirect.com/science/article/pii/S0378112717309507

  19. Mainstreaming: "I Simply Wanted My Sister to Be a Bridesmaid"

    Science.gov (United States)

    Schleifer, Maxwell J., Ed.

    1978-01-01

    Presented is a case history centering around a family controversy over the inclusion of a cerebral palsied sister in a wedding ceremony, which illustrates some of the difficulties of adjusting to and accepting a physically handicapped child in the family. (DLS)

  20. Sister M. Madeleva Wolff, C.S.C.

    Science.gov (United States)

    Petit, M. Loretta

    2006-01-01

    Sister M. Madeleva Wolff, C.S.C., teacher, essayist, poet, and college administrator, through her creative ability and innovative practices made possible major contributions to Catholic education in her lifetime. Without her strong personality and boundless energy, many of her dreams for an ideal college curriculum would not have come to fruition.…

  1. OGRS2012 Symposium Proceedings

    OpenAIRE

    Ertz, Olivier; Joost, Stéphane; Tonini, Marj

    2012-01-01

    Do you remember the Open Source Geospatial Research and Education Symposium (OGRS) in Nantes? "Les Machines de l’Île", the Big Elephant, the "Storm Boat" with Claramunt, Petit et al. (2009), and "le Biniou et la Bombarde"? A second edition of OGRS was promised, and that promise is now fulfilled in OGRS 2012, Yverdon-les-Bains, Switzerland, October 24-26, 2012. OGRS is a meeting dedicated to sharing knowledge, new solutions, methods, practices, ideas and trends in the field of geospatial infor...

  2. SYMPOSIUM: Rare decays

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    Late last year, a symposium entitled 'Rare Decays' attracted 115 participants to a hotel in Vancouver, Canada. These participants were particle physicists interested in checking conventional selection rules to look for clues of possible new behaviour outside today's accepted 'Standard Model'. For physicists, 'rare decays' include processes that have so far not been seen, explicitly forbidden by the rules of the Standard Model, or processes highly suppressed because the decay is dominated by an easier route, or includes processes resulting from multiple transitions

  3. Symposium Gyro Technology 1997

    Energy Technology Data Exchange (ETDEWEB)

    Sorg, H. [ed.] [Stuttgart Univ. (Germany). Inst. A fuer Mechanik

    1997-10-01

    This volume includes the twenty papers which were presented at the Symposium Gyro Technology 1997. The subjects that have been treated during the symposium were as follows: Performance and design of silicon micromachined gyro; improved rate gyroscope designs designated for fabrication by modern deep silicon etching; micromechanical vibratory rate gyroscopes fabricated in conventional CMOS; error modelling of silicon angular rate sensor; a capacitive accelerometer as an example for surface micromachined inertial sensors; initial production results of a new family of fiber optic gyroscopes; dual-axis multiplexed open loop fiber optic gyroscope; flattely supported vibratory gyro-sensor using a Trident-type tuning fork resonator; innovative mechanizations to optimize inertial sensors for high or low rate operations; design of a planar vibratory gyroscope using electrostatic actuation and electromanetic detection; fiber optic gyro based land navigation system; FOG AHRS and AHRS/GPS navigation system: the low cost solution; GPS/GLONASS/INS-navigation (GLOGINAV); small-sized integrated system of the sea mobile objects attitude and navigation; concepts for hybrid positioning; preliminary results from a large ring laser gyroscope for fundamental physics and geophysics; a `sense of balance` - AHRS with low-cost vibrating-gyroscopes for medical diagnostics; application of strapdown inertial systems of orientation and navigation in intrapipe moving diagnostic apparatus; investigation of a digital readout system for laser gyro; the use of angular rate multiple integrals as input signals for strapdown attitude algorithms. (AKF)

  4. NIC symposium 2010. Proceedings

    International Nuclear Information System (INIS)

    Muenster, Gernot

    2012-01-01

    The fifth NIC-Symposium gave an overview of the activities of the John von Neumann Institute for Computing (NIC) and of the results obtained in the last two years by research groups supported by the NIC. The large recent progress in supercomputing is highlighted by the fact that the newly installed Blue Gene/P system in Juelich - with a peak performance of 1 Petaflop/s - currently ranks number four in the TOP500 list. This development opens new dimensions in simulation science for researchers in Germany and Europe. NIC - a joint foundation of Forschungszentrum Juelich, Deutsches Elektronen-Synchrotron (DESY) and Gesellschaft fuer Schwerionenforschung (GSI) - supports with its members' supercomputer facilities about 130 research groups at universities and national labs working on computer simulations in various fields of science. Fifteen invited lectures covered selected topics in the following fields: Astrophysics Biophysics Chemistry Elementary Particle Physics Condensed Matter Materials Science Soft Matter Science Environmental Research Hydrodynamics and turbulence Plasma Physics Computer Science The talks are intended to inform a broad audience of scientists and the interested public about the research activities at NIC. The proceedings of the symposium cover projects that have been supported by the IBM supercomputers JUMP and IBM Blue Gene/P in Juelich and the APE topical computer at DESY-Zeuthen in an even wider range than the lectures.

  5. NIC symposium 2010. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Muenster, Gernot [Muenster Univ. (Germany). Inst. fuer Theoretische Physik 1; Wolf, Dietrich [Duisburg-Essen Univ., Duisburg (Germany). Fakultaet fuer Physik; Kremer, Manfred (eds.) [Forschungszentrum Juelich GmbH (DE). Juelich Supercomputing Centre (JSC)

    2012-06-21

    The fifth NIC-Symposium gave an overview of the activities of the John von Neumann Institute for Computing (NIC) and of the results obtained in the last two years by research groups supported by the NIC. The large recent progress in supercomputing is highlighted by the fact that the newly installed Blue Gene/P system in Juelich - with a peak performance of 1 Petaflop/s - currently ranks number four in the TOP500 list. This development opens new dimensions in simulation science for researchers in Germany and Europe. NIC - a joint foundation of Forschungszentrum Juelich, Deutsches Elektronen-Synchrotron (DESY) and Gesellschaft fuer Schwerionenforschung (GSI) - supports with its members' supercomputer facilities about 130 research groups at universities and national labs working on computer simulations in various fields of science. Fifteen invited lectures covered selected topics in the following fields: Astrophysics Biophysics Chemistry Elementary Particle Physics Condensed Matter Materials Science Soft Matter Science Environmental Research Hydrodynamics and turbulence Plasma Physics Computer Science The talks are intended to inform a broad audience of scientists and the interested public about the research activities at NIC. The proceedings of the symposium cover projects that have been supported by the IBM supercomputers JUMP and IBM Blue Gene/P in Juelich and the APE topical computer at DESY-Zeuthen in an even wider range than the lectures.

  6. International Evoked Potentials Symposium

    CERN Document Server

    1980-01-01

    The past decade has seen great progress in the measurement of evoked potentials in man; a steady increase in our understanding of their charac­ teristics, their origins and their usefulness; and a growing application in the field of clinical diagnosis. The topic is a truly multidisciplinary one. Important research contributions have been made by workers of many different backgrounds and clinical applications span the specialities. This book represents a revised and updated version of the work originally presented at the international evoked potential symposium held in Nottingham 4-6 1978. The Nottingham Symposium provided a forum for a state-of-the-art discussion amongst workers from many different disciplines and from many different countries. For each major topic in the field an expert review set the scene for discussion of current research presentations. This format is retained in the book: the chapters in Part A provide the context in which the research presented in Part B is set. The task of selecting m...

  7. Constructing and enacting kinship in sister-to-sister egg donation families: a multi-family member interview study.

    Science.gov (United States)

    Van Parys, Hanna; Provoost, Veerle; Zeiler, Kristin; De Sutter, Petra; Pennings, Guido; Buysse, Ann

    2017-07-01

    Although intra-familial egg donation has been practiced for more than 15 years in several countries, little is known about family relationships in this family type. Framed within the new kinship studies, this article focuses on the experiential dimension of kinship in sister-to-sister egg donation families: how is kinship 'unpacked' and 'reconstructed' in this specific family constellation? Qualitative data analysis of interviews with receiving parents, their donating sisters and the donor children revealed six themes: (1) being connected as an extended family; (2) disambiguating motherhood; (3) giving and receiving as structuring processes; (4) acknowledging and managing the 'special' link between donor and child; (5) making sense of the union between father and donor; and (6) kinship constructions being challenged. This study showed the complex and continuous balancing of meanings related to the mother-child dyad, the donor-child dyad and the donor-father dyad. What stood out was the complexity of, on the one hand cherishing the genetic link with the child allowed by the sisters' egg donation, while, on the other, managing the meanings related to this link, by, for instance, acknowledging, downsizing, symbolising, and differentiating it from the mother-child bond. (A Virtual Abstract of this paper can be accessed at: https://www.youtube.com/channel/UC_979cmCmR9rLrKuD7z0ycA). © 2016 Foundation for the Sociology of Health & Illness.

  8. Persistence of chromatid damage after G2 phase X-irradiation in lymphoblastoid cells from Gardner's syndrome

    International Nuclear Information System (INIS)

    Takai, Setsuo; Price, F.M.; Sanford, K.K.; Tarone, R.E.; Parshad, Ram

    1990-01-01

    Previous reports showed that skin fibroblasts or peripheral blood lymphocytes from individuals with hereditary cancer or with a genetic disorder predisposing to cancer show an abnormally high frequency of chromatid damage after X-irradiation in G 2 phase. The reproducibility of this response suggested that it could provide the basis of an assay for genetic predisposition to cancer. The present blind study tested whether lymphoblastoid cell lines could also be used in this assay. Lymphoblastoid cell lines from patients with Gardner's syndrome (GS) were compared with those from clinically normal controls. In metaphase cells collected during the first 30 min after X-irradiation (58R), frequencies of chromatid breaks and gaps were similar in GS and normal cells. However, in metaphase cells collected from 0.5 to 1.5 h and 1.5 to 2.5 h after X-irradiation, the total unrepaired damage for each GS cell line was greater than that observed in any of the lines from clinically normal controls. The persistence of chromatid damage in the GS cells after X-irradiation suggests a deficiency or imbalance in the repair or processing of the radiation-induced DNA damage. The results show that lymphoblastoid cell lines in early passage can be used in this cytogenetic assay to identify members in a GS family who have the GS gene(s) or other individuals with a genetic predisposition to cancer. (author)

  9. Biochemical evidence for deficient DNA repair leading to enhanced G2 chromatid radiosensitivity and susceptibility to cancer

    International Nuclear Information System (INIS)

    Gantt, R.; Parshad, R.; Price, F.M.; Sanford, K.K.

    1986-01-01

    Human tumor cells and cells from cancer-prone individuals, compared with those from normal individuals, show a significantly higher incidence of chromatid breaks and gaps seen in metaphase cells immediately after G2 X irradiation. Previous studies with DNA repair-deficient mutants and DNA repair inhibitors strongly indicate that the enhancement results from a G2 deficiency(ies) in DNA repair. We report here biochemical evidence for a DNA repair deficiency that correlates with the cytogenetic studies. In the alkaline elution technique, after a pulse label with radioactive thymidine in the presence of 3-acetylaminobenzamide (a G2-phase blocker) and X irradiation, DNA from tumor or cancer-prone cells elutes more rapidly during the postirradiation period than that from normal cells. These results indicate that the DNA of tumor and cancer-prone cells either repairs more slowly or acquires more breaks than that of normal cells; breaks can accumulate during incomplete or deficient repair processes. The kinetic difference between normal and tumor or cancer-prone cells in DNA strand-break repair reaches a maximum within 2 h, and this maximum corresponds to the kinetic difference in chromatid aberration incidence following X irradiation reported previously. These findings support the concept that cells showing enhanced G2 chromatid radiosensitivity are deficient in DNA repair. The findings could also lead to a biochemical assay for cancer susceptibility

  10. VIII international electric vehicle symposium

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    The proceedings from the symposium are presented. Major topics discussed include: battery technology, powertrains; hybrid vehicles, marketing and economics, propulsion, and electric vehicle design and performance. Each paper has been separately indexed for inclusion in the Energy Data Base.

  11. Fourth symposium on macrocyclic compounds

    International Nuclear Information System (INIS)

    Christensen, J.J.; Izatt, R.M.

    1980-01-01

    Both theoretical and experimental aspects of the properties and behavior of synthetic and naturally occurring macrocyclic compounds are covered in this symposium. This document contains abstracts of the papers

  12. Research symposium proceedings. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-12-31

    THE research symposium was organized to present the cutting edge research for PET by individuals from leading institutions throughout the world. The Institute for Clinical PET (ICP) has focused its annual meeting on the clinical applications of PET.

  13. International symposium on NMR spectroscopy

    International Nuclear Information System (INIS)

    The publication consists of 32 papers and presentations from the field of NMR spectroscopy applications submitted to the International Symposium on NMR Spectroscopy held at Smolenice between 29 Sep and 3 Oct, 1980. (B.S.)

  14. Third Symposium on Macrocyclic Compounds

    International Nuclear Information System (INIS)

    1979-01-01

    At the Third Symposium on Macrocyclic Compounds there were sessions on facilitated transport, analytical applications, organic synthesis and reactions, phase transfer catalysis, and metal complexation. Abstracts of the individual presentations are included

  15. Proceedings Forest & Field Fuels Symposium

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-07-01

    The purpose of the symposium is to examine two specific renewable resources, forest and field fuels, to pinpoint areas where funding of RD&D would be effective in expanding their marketability and use as substitutes for imported oil.

  16. Implementasi Sister Province Provinsi Jawa Tengah Dengan Negara Bagian Queensland Australia Di Bidang Pertanian

    OpenAIRE

    Windiani, Reni

    2014-01-01

    Globalization on national context has insisted the central government to work together and share duties and rights with the local government in order to achieve the national interest. In Indonesia, UU 32/2004 about local government provide the chance for them to become more active in foreign policy, such as doing the cooperation in sister province/sister city program.The Central Java Province had done many sister province/sister city program with some partners aboard, such as Fujian province...

  17. 30th Aerospace Mechanisms Symposium

    Science.gov (United States)

    Bradley, Obie H., Jr. (Compiler); Rogers, John F. (Compiler)

    1996-01-01

    The proceedings of the 30th Aerospace Mechanisms Symposium are reported. NASA Langley Research Center hosted the proceedings held at the Radisson Hotel in Hampton, Virginia on May 15-17, 1996, and Lockheed Martin Missiles and Space Company, Inc. co-sponsored the symposium. Technological areas covered include bearings and tribology; pointing, solar array, and deployment mechanisms; orbiter/space station; and other mechanisms for spacecraft.

  18. Testing of the "Healthy 'Little' Lives Project": A Training Program for Big Sister Mentors

    Science.gov (United States)

    Kaufman, Michelle R.

    2010-01-01

    Big Brothers/Big Sisters is a national program aimed at providing mentors for disadvantaged children. This study tested whether Big Sister mentors could be trained to increase communication with their Little Sisters about sexual health issues. The study tested an intervention based on social cognitive theory in which a sexual health communication…

  19. 10th Schaeffler Symposium

    CERN Document Server

    2014-01-01

    Every four years, Schaeffler provides an insight into its latest developments and technologies from the engine, transmission and chassis as well as hybridization and electric mobility sectors. In 2014 the Schaeffler Symposium with the motto “Solving the Powertrain Puzzle” took place from 3th to 4th of April in Baden-Baden. Mobility for tomorrow is the central theme of this proceeding. The authors are discussing the different requirements, which are placed on mobility in different regions of the world. In addition to the company's work in research and development, a comprehensive in-house mobility study also provides a reliable basis for the discussion. The authors are convinced that there will be a paradigm shift in the automotive industry. Issues such as increasing efficiency and advancing electrification of the powertrain, automatic and semi-automatic driving, as well as integration in information networks will define the automotive future. In addition, the variety of solutions available worldwide will ...

  20. Renewable Energy Symposium

    International Nuclear Information System (INIS)

    2016-01-01

    Representatives of state universities, public institutions and Costa Rican private sector, and American experts have exposed projects or experiences about the use and generation of renewable energy in different fields. The thematics presented have been about: development of smart grids and design of electrical energy production systems that allow money saving and reducing emissions to the environment; studies on the use of non-traditional plants and agricultural waste; sustainable energy model in the process of coffee production; experiments from biomass for the fabrication of biodiesel, biogas production and storage; and the use of non-conventional energy. Researches were presented at the Renewable Energy Symposium, organized by the Centro de Investigacion en Estructuras Microscopicas and support of the Vicerrectoria de Investigacion, both from the Universidad de Costa Rica [es

  1. Automated Vehicles Symposium 2014

    CERN Document Server

    Beiker, Sven; Road Vehicle Automation 2

    2015-01-01

    This paper collection is the second volume of the LNMOB series on Road Vehicle Automation. The book contains a comprehensive review of current technical, socio-economic, and legal perspectives written by experts coming from public authorities, companies and universities in the U.S., Europe and Japan. It originates from the Automated Vehicle Symposium 2014, which was jointly organized by the Association for Unmanned Vehicle Systems International (AUVSI) and the Transportation Research Board (TRB) in Burlingame, CA, in July 2014. The contributions discuss the challenges arising from the integration of highly automated and self-driving vehicles into the transportation system, with a focus on human factors and different deployment scenarios. This book is an indispensable source of information for academic researchers, industrial engineers, and policy makers interested in the topic of road vehicle automation.

  2. Objectives of the symposium

    International Nuclear Information System (INIS)

    Genter, N.E.

    1996-01-01

    The objective of this symposium was to discuss the sorts of evidence of molecular alterations in DNA which can be used to study causation of the stochastic effects of importance in radiation protection. Specifically, the aim was to address the following: what sort of indications might show whether a cancer was caused by radiation; whether there is a radiogenic signature to distinguish damage caused by ionizing radiation; whether bio-markers might be available for susceptibility, for exposure, for biological consequences. Despite a number of epidemiological studies (referred to), there is no clear, credible, defensible answer as to whether low-level radiation increases the risk of cancer. A new ethical question is, what rules should be in place for identifying and protecting genetically sensitive individuals. 1 tab

  3. 2nd Abel Symposium

    CERN Document Server

    Nunno, Giulia; Lindstrøm, Tom; Øksendal, Bernt; Zhang, Tusheng

    2007-01-01

    Kiyosi Ito, the founder of stochastic calculus, is one of the few central figures of the twentieth century mathematics who reshaped the mathematical world. Today stochastic calculus is a central research field with applications in several other mathematical disciplines, for example physics, engineering, biology, economics and finance. The Abel Symposium 2005 was organized as a tribute to the work of Kiyosi Ito on the occasion of his 90th birthday. Distinguished researchers from all over the world were invited to present the newest developments within the exciting and fast growing field of stochastic analysis. The present volume combines both papers from the invited speakers and contributions by the presenting lecturers. A special feature is the Memoirs that Kiyoshi Ito wrote for this occasion. These are valuable pages for both young and established researchers in the field.

  4. 3rd Abel Symposium

    CERN Document Server

    Owren, Brynjulf

    2008-01-01

    The 2006 Abel symposium is focusing on contemporary research involving interaction between computer science, computational science and mathematics. In recent years, computation has been affecting pure mathematics in fundamental ways. Conversely, ideas and methods of pure mathematics are becoming increasingly important within computational and applied mathematics. At the core of computer science is the study of computability and complexity for discrete mathematical structures. Studying the foundations of computational mathematics raises similar questions concerning continuous mathematical structures. There are several reasons for these developments. The exponential growth of computing power is bringing computational methods into ever new application areas. Equally important is the advance of software and programming languages, which to an increasing degree allows the representation of abstract mathematical structures in program code. Symbolic computing is bringing algorithms from mathematical analysis into the...

  5. Automated Vehicles Symposium 2015

    CERN Document Server

    Beiker, Sven

    2016-01-01

    This edited book comprises papers about the impacts, benefits and challenges of connected and automated cars. It is the third volume of the LNMOB series dealing with Road Vehicle Automation. The book comprises contributions from researchers, industry practitioners and policy makers, covering perspectives from the U.S., Europe and Japan. It is based on the Automated Vehicles Symposium 2015 which was jointly organized by the Association of Unmanned Vehicle Systems International (AUVSI) and the Transportation Research Board (TRB) in Ann Arbor, Michigan, in July 2015. The topical spectrum includes, but is not limited to, public sector activities, human factors, ethical and business aspects, energy and technological perspectives, vehicle systems and transportation infrastructure. This book is an indispensable source of information for academic researchers, industrial engineers and policy makers interested in the topic of road vehicle automation.

  6. Design Modelling Symposium 2015

    CERN Document Server

    Tamke, Martin; Gengnagel, Christoph; Faircloth, Billie; Scheurer, Fabian

    2015-01-01

    This book reflects and expands on the current trend in the building industry to understand, simulate and ultimately design buildings by taking into consideration the interlinked elements and forces that act on them. This approach overcomes the traditional, exclusive focus on building tasks, while posing new challenges in all areas of the industry from material and structural to the urban scale. Contributions from invited experts, papers and case studies provide the reader with a comprehensive overview of the field, as well as perspectives from related disciplines, such as computer science. The chapter authors were invited speakers at the 5th Symposium "Modelling Behaviour", which took place at the CITA in Copenhagen in September 2015.

  7. NATO Telecommunications Symposium

    CERN Document Server

    Lucas, William; Conrath, David

    1978-01-01

    This book contains the proceedings of the first international symposium devoted to research on the evaluation and planning of new person-to-person telecommunication systems. It was sponsored by NATO's Special Programme Panel on Systems Science and took place, in September 1977, at the University of Bergamo in the north of Italy. Telecommunication systems which provide for communication be­ tween people, rather than computers or other instruments, are of two kinds. There are mass communication systems (broadcast radio and television) and interpersonal systems (for example, the telephone and Telex) which join together individuals or small groups. Here we have included in the interpersonal category certain systems for re­ trieving information from computers, essentially those systems in which the role of the computer 1s primarily to act as a store and to identify that information which best fits a user's request. (This excludes management information systems in which the computer performs important transformat...

  8. Living with a brother or sister with epilepsy: siblings' experiences.

    Science.gov (United States)

    Hames, Annette; Appleton, Richard

    2009-12-01

    There is conflicting evidence about the impact of disability upon siblings, and very little research on the siblings of children with epilepsy. There is some evidence that siblings who have less accurate information exhibit more distress. The aim of this study was to assess siblings' response to having a brother or sister with epilepsy and to begin to develop information for them. Parents of children attending paediatric neurology outpatient departments were invited to participate in a pilot study. Parents who consented to take part were asked if they had previously received information for siblings. Parents and siblings participated in a semi-structured interview and siblings were also invited to submit a personal account of living with a brother or sister who had epilepsy. Twenty-five families with a child with epilepsy aged 2.5-15 years initially agreed to take part. None of the families stated that they had ever seen or received any information specifically for siblings. Fourteen siblings from the 25 families, aged 8-25 years, provided a personal account of what it was like living with a brother or sister with epilepsy. Siblings' accounts included both negative and positive feelings, and specifically feelings of care and love for their sibling. This initial study suggests that siblings of children with epilepsy have many positive but also early negative feelings. The results are limited by the size of the study, the fact that most siblings were older sisters, and the mean time since diagnosis was 6 years. Finally, it is hoped that the personal accounts collected in this study will be published for the benefit of other siblings of children with epilepsy.

  9. Broad phylogenomic sampling and the sister lineage of land plants.

    Science.gov (United States)

    Timme, Ruth E; Bachvaroff, Tsvetan R; Delwiche, Charles F

    2012-01-01

    The tremendous diversity of land plants all descended from a single charophyte green alga that colonized the land somewhere between 430 and 470 million years ago. Six orders of charophyte green algae, in addition to embryophytes, comprise the Streptophyta s.l. Previous studies have focused on reconstructing the phylogeny of organisms tied to this key colonization event, but wildly conflicting results have sparked a contentious debate over which lineage gave rise to land plants. The dominant view has been that 'stoneworts,' or Charales, are the sister lineage, but an alternative hypothesis supports the Zygnematales (often referred to as "pond scum") as the sister lineage. In this paper, we provide a well-supported, 160-nuclear-gene phylogenomic analysis supporting the Zygnematales as the closest living relative to land plants. Our study makes two key contributions to the field: 1) the use of an unbiased method to collect a large set of orthologs from deeply diverging species and 2) the use of these data in determining the sister lineage to land plants. We anticipate this updated phylogeny not only will hugely impact lesson plans in introductory biology courses, but also will provide a solid phylogenetic tree for future green-lineage research, whether it be related to plants or green algae.

  10. Broad phylogenomic sampling and the sister lineage of land plants.

    Directory of Open Access Journals (Sweden)

    Ruth E Timme

    Full Text Available The tremendous diversity of land plants all descended from a single charophyte green alga that colonized the land somewhere between 430 and 470 million years ago. Six orders of charophyte green algae, in addition to embryophytes, comprise the Streptophyta s.l. Previous studies have focused on reconstructing the phylogeny of organisms tied to this key colonization event, but wildly conflicting results have sparked a contentious debate over which lineage gave rise to land plants. The dominant view has been that 'stoneworts,' or Charales, are the sister lineage, but an alternative hypothesis supports the Zygnematales (often referred to as "pond scum" as the sister lineage. In this paper, we provide a well-supported, 160-nuclear-gene phylogenomic analysis supporting the Zygnematales as the closest living relative to land plants. Our study makes two key contributions to the field: 1 the use of an unbiased method to collect a large set of orthologs from deeply diverging species and 2 the use of these data in determining the sister lineage to land plants. We anticipate this updated phylogeny not only will hugely impact lesson plans in introductory biology courses, but also will provide a solid phylogenetic tree for future green-lineage research, whether it be related to plants or green algae.

  11. Paternity testing in case of brother-sister incest.

    Science.gov (United States)

    Macan, Marijana; Uvodić, Petra; Botica, Vladimir

    2003-06-01

    We performed a paternity test in a case of incest between brother and sister. DNA from blood samples of the alleged parents and their two children was obtained with Chelex DNA extraction method and quantified with Applied Biosystems QuantiBlot quantitation kit. Polymerase chain reaction (PCR) amplification of DNA samples was performed with AmpFlSTR SGM Plus PCR amplification kit and GenePrint PowerPlex PCR amplification kit. The amplified products were separated and detected by using the Perkin Elmer's ABI PRISM trade mark 310 Genetic Analyser. DNA and data analysis of 17 loci and Amelogenin confirmed the suspicion of brother-sister incest. Since both children had inherited all of the obligate alleles from the alleged father, we could confirm with certainty of 99.999999% that the oldest brother in the family was the biological father of both children. Calculated data showed that even in a case of brother-sister incest, paternity could be proved by the analysis of Amelogenin and 17 DNA loci.

  12. North European Symposium for Archaeological Textiles X

    DEFF Research Database (Denmark)

    Proceedings of the Tenth North European Symposium for Archaeological Textiles, held in Copenhagen, 14-17 May 2008......Proceedings of the Tenth North European Symposium for Archaeological Textiles, held in Copenhagen, 14-17 May 2008...

  13. International Symposium on Nuclear Safety

    International Nuclear Information System (INIS)

    2013-03-01

    Nuclear Regulatory Authority of the Slovak Republic and the Embassy of Japan in the Slovak Republic, under the auspices of the Deputy Prime Minister and Minister of Foreign and European Affairs Mr Lajcak organized International Symposium on Nuclear Safety on 14 and 15 March 2013. The symposium took place almost exactly two years after the occurrence of accidents at the Japanese nuclear power plant Fukushima Daichi. The main mission of the symposium was an attempt to contribute to the improvement of nuclear safety by sharing information and lessons presented by Japanese experts with experts from the region, the International Atomic Energy Agency (IAEA) and the European Commission. The aim of the symposium, unlike many other events organized in connection with the events in Fukushima Daichi NPP, was a summary of the results of stress tests and measures update adopted by the international community, especially within Europe. Panel discussion was included to the program of the symposium for this aim was, mainly focused on the current state of implementation of the National Action Plan of the Slovak Republic, the Czech Republic, Poland, Ukraine and Switzerland and the IAEA Action Plan.

  14. The 1956 CERN Symposium

    CERN Document Server

    Jarlskog, Cecilia

    2014-01-01

    CERN, currently the largest organization in the world for particle physics, was founded in 1954. Originally located in Meyrin, at the outskirts of the city of Geneva in Switzerland, it has with time extended into neighboring France. The Theoretical Study Division of CERN, however, was created already in 1952, i.e., before the official inauguration of CERN. It was situated in Copenhagen. Christian Møller [1] was appointed (part-time) as the Director and there were two full time senior staff members, Gunnar Källén and Ben R. Mottelson. While constructing buildings and accelerators were in progress, an international conference was organized by CERN in the city of Geneva. This “CERN Symposium on High Energy Accelerators and Pion Physics”, 11–23 June 1956, attracted about 250 participants from outside CERN, among them at least 18 Nobel Laureates or future Laureates. Unfortunately, the participants from CERN are not listed in the Proceedings [2]. The conference focused on measuring devices such as bubbl...

  15. Sisters who developed piloerection after administration of milnacipran.

    Science.gov (United States)

    Matsuo, Nobuko; Hori, Satoko; Suehira, Mayu; Satoh, Hiroki; Miki, Akiko; Sawada, Yasufumi

    2016-03-01

    We previously reported the first case of piloerection in a patient receiving milnacipran hydrochloride (MLP). Here, we now present a second case of MLP-induced piloerection. We discuss this effect in terms of α1-adrenoceptor occupancy. After the first case of MLP-induced piloerection, we monitored occurrence of piloerection in our patients taking MLP. In response to our interview, a 43-year-old woman who had been prescribed MLP by a psychiatrist for depression mentioned that piloerection occurred frequently all over her body, starting soon after initiation of MLP administration (50 mg/day). Although she was concerned at the time, she assumed it might be related to her depression or to coldness in winter. She also mentioned that the incidence of piloerection increased with MLP dose escalation. The piloerection disappeared after several months. Interestingly, the previous patient and the current patient are biological sisters. Changes in α1-adrenoceptor occupancy by endogenous norepinephrine (as an index of the risk of piloerection) in the presence of MLP were estimated. The occupancy values increased with MLP dose escalation, in accordance with the patient's report of the phenomenon. other concomitant drugs, such as nortriptyline, had little effect. Since the two patients were sisters, genetic factors might influence the risk of piloerection. The incidence of piloerection appeared to increase with MLP dose escalation in this patient, who was the biological sister of the previously reported patient. Clinicians should recognize the possibility of MLP-induced piloerection in view of its potential impact on patients' quality of life and on drug compliance.

  16. 43rd Aerospace Mechanisms Symposium

    Science.gov (United States)

    Boesiger, Edward A.

    2016-01-01

    The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development and flight certification of new mechanisms. Sponsored and organized by the Mechanisms Education Association, responsibility for hosting the AMS is shared by the National Aeronautics and Space Administration and Lockheed Martin Space Systems Company (LMSSC). Now in its 43rd symposium, the AMS continues to be well attended, attracting participants from both the U.S. and abroad. The 43rd AMS was held in Santa Clara, California on May 4, 5 and 6, 2016. During these three days, 42 papers were presented. Topics included payload and positioning mechanisms, components such as hinges and motors, CubeSats, tribology, and mechanism testing. Hardware displays during the supplier exhibit gave attendees an opportunity to meet with developers of current and future mechanism components. The high quality of this symposium is a result of the work of many people, and their efforts are gratefully acknowledged. This extends to the voluntary members of the symposium organizing committee representing the eight NASA field centers, LMSSC, and the European Space Agency. Appreciation is also extended to the session chairs, the authors, and particularly the personnel at ARC responsible for the symposium arrangements and the publication of these proceedings. A sincere thank you also goes to the symposium executive committee who is responsible for the year-to-year management of the AMS, including paper processing and preparation of the program. The use of trade names of manufacturers in this publication does not constitute an official endorsement of such products or manufacturers, either expressed or implied, by the National Aeronautics and Space Administration.

  17. Agenesis of the Gallbladder in Monozygotic Twin Sisters

    Directory of Open Access Journals (Sweden)

    Koki Hoshi

    2016-01-01

    Full Text Available Agenesis of the gallbladder, a rare anomaly, is generally regarded as an organogenic failure. Several reports suggest that this congenital defect is inherited but that supposition remains controversial. We described agenesis of the gallbladder in identical twins. A 21-year-old female presented with a history of acute pain in the epigastrium and right hypochondrium. Various imaging modalities showed “gallbladder agenesis.” Moreover, her older identical twin sister had also no visualized gallbladder in imaging modalities. This case report strongly suggested that agenesis of the gallbladder would be caused by a genetic abnormality.

  18. [Wolfram syndrome: clinical and genetic analysis in two sisters].

    Science.gov (United States)

    Conart, J-B; Maalouf, T; Jonveaux, P; Guerci, B; Angioi, K

    2011-10-01

    Wolfram syndrome is a severe genetic disorder defined by the association of diabetes mellitus, optic atrophy, deafness, and diabetes insipidus. Two sisters complained of progressive visual loss. Fundus examination evidenced optic atrophy. Their past medical history revealed diabetes mellitus and deafness since childhood. The association of these symptoms made the diagnosis of Wolfram syndrome possible. It was confirmed by molecular analysis, which evidenced composite WFS1 heterozygous mutations inherited from both their mother and father. Ophthalmologists should be aware of the possibility of Wolfram syndrome when diagnosing optic atrophy in diabetic children. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

  19. Il progetto SISTER per il comune di Lignano Sabbiadoro

    Directory of Open Access Journals (Sweden)

    Alberto Poli

    2005-10-01

    Full Text Available Il comune di Lignano è stato recentemente invitato a Roma in qualità di relatore alla conferenza nazionale dei sistemi informativi territoriali organizzata da Esri, il maggior produttore mondiale di software per la gestione delle cartografie informatizzate. In tale occasione l’assessore AngeloBonelli ha presentato il progetto sperimentale di sistema informatico per la gestione del territorio, che è in corso da circa un anno. Ecco la sintesi della relazione del Sistema Informativo Integrato Territoriale (SISTER realizzato da Politecnica.

  20. Mining and Reclamation Technology Symposium

    Energy Technology Data Exchange (ETDEWEB)

    None Available

    1999-06-24

    The Mining and Reclamation Technology Symposium was commissioned by the Mountaintop Removal Mining/Valley Fill Environmental Impact Statement (EIS) Interagency Steering Committee as an educational forum for the members of the regulatory community who will participate in the development of the EIS. The Steering Committee sought a balanced audience to ensure the input to the regulatory community reflected the range of perspectives on this complicated and emotional issue. The focus of this symposium is on mining and reclamation technology alternatives, which is one of eleven topics scheduled for review to support development of the EIS. Others include hydrologic, environmental, ecological, and socio-economic issues.

  1. Cortical Pathology in RRMS: Taking a Cue from Four Sisters

    Directory of Open Access Journals (Sweden)

    Massimiliano Calabrese

    2012-01-01

    Full Text Available Background. Although grey matter pathology is a relevant aspect of multiple sclerosis (MS both with physical and cognitive rebounds, its pathogenesis is still under investigation. To what extent the familial and sporadic cases of MS differ in cortical pathology has not been elucidated yet. Here we present a multiple case report of four sisters affected by MS, all of them having a very high burden of cortical pathology. Methods. The clinical and grey matter MRI parameters of the patients were compared with those of twenty-five-aged matched healthy women and 25 women affected by sporadic MS (matched for age, disease duration, EDSS, and white matter lesion load. Results. Despite their short disease duration (<5 years, the four sisters showed a significant cortical thinning compared to healthy controls ( and sporadic MS ( and higher CLs number ( and volume ( compared to sporadic MS. Discussion. Although limited to a single family, our observation is worth of interest since it suggests that familial factors may account for a peculiar involvement of the cortex in MS pathology. This hypothesis should be further evaluated in a large number of multiplex MS families.

  2. Sister chromosome pairing maintains heterozygosity in parthenogenetic lizards.

    Science.gov (United States)

    Lutes, Aracely A; Neaves, William B; Baumann, Diana P; Wiegraebe, Winfried; Baumann, Peter

    2010-03-11

    Although bisexual reproduction has proven to be highly successful, parthenogenetic all-female populations occur frequently in certain taxa, including the whiptail lizards of the genus Aspidoscelis. Allozyme analysis revealed a high degree of fixed heterozygosity in these parthenogenetic species, supporting the view that they originated from hybridization events between related sexual species. It has remained unclear how the meiotic program is altered to produce diploid eggs while maintaining heterozygosity. Here we show that meiosis commences with twice the number of chromosomes in parthenogenetic versus sexual species, a mechanism that provides the basis for generating gametes with unreduced chromosome content without fundamental deviation from the classic meiotic program. Our observation of synaptonemal complexes and chiasmata demonstrate that a typical meiotic program occurs and that heterozygosity is not maintained by bypassing recombination. Instead, fluorescent in situ hybridization probes that distinguish between homologues reveal that bivalents form between sister chromosomes, the genetically identical products of the first of two premeiotic replication cycles. Sister chromosome pairing provides a mechanism for the maintenance of heterozygosity, which is critical for offsetting the reduced fitness associated with the lack of genetic diversity in parthenogenetic species.

  3. Symposium: What Is College English?

    Science.gov (United States)

    Bloom, Lynn Z.; White, Edward M.; Enoch, Jessica; Hawk, Byron

    2013-01-01

    This symposium explores the role(s) College English has (or has not) had in the scholarly work of four scholars. Lynn Bloom explores the many ways College English influenced her work and the work of others throughout their scholarly lives. Edward M. White examines four articles he has published in College English and draws connections between…

  4. Copyright Law Symposium. No. 23.

    Science.gov (United States)

    American Society of Composers, Authors and Publishers, New York, NY.

    This book presents the five national prizewinning papers in the twenty-third copyright law symposium conducted by the American Society of Composers, Authors, and Publishers (ASCAP). Titles of the papers are "The USSR Joins the Universal Copyright Convention" (first prize), "Copyright Misuse: Thirty Years Waiting for the Other…

  5. Sudden oak death online symposium

    Science.gov (United States)

    S.D. Cohen; J., eds Juzwik

    2003-01-01

    This symposium is being made available to all who have an interest in the recent appearance of Sudden Oak Death, a plant disease with the potential to severely impact nursery growers, shippers, the lumber and wood products industry, landscapers, government programs and others. Scientific presentations dealing with the current status of the disease and ongoing research...

  6. Diversity in the Workplace. Symposium.

    Science.gov (United States)

    2002

    Three papers comprise this symposium on diversity in the workplace. "Factors That Assist and Barriers That Hinder the Success of Diversity Initiatives in Multinational Corporations" (Rose Mary Wentling) reports that factors that assisted in the success were classified under diversity department, human, and work environment; barriers were…

  7. Indian symposium reviews tsunami response

    Directory of Open Access Journals (Sweden)

    Paula Banerjee

    2005-07-01

    Full Text Available A symposium of academics and human rights activists organised by the Calcutta Research Group assessed the extent to which relief and rehabilitation initiatives in Tamil Nadu and the Andaman and Nicobar islands have recognised the rights of those affected to receive aid without discrimination based on caste, religion or gender.

  8. 11. European cosmic ray symposium

    International Nuclear Information System (INIS)

    1989-03-01

    The biannual Symposium includes all aspects of cosmic ray research. The scientific programme was organized under three main headings: Cosmic rays in the heliosphere, Cosmic rays in the interstellar and extragalactic space, Properties of high-energy interactions as studied by cosmic rays. Seven invited talks were indexed seprately for the INIS database. (R.P.)

  9. SYMPOSIUM ON PLANT PROTEIN PHOSPHORYLATION

    Energy Technology Data Exchange (ETDEWEB)

    JOHN C WALKER

    2011-11-01

    Protein phosphorylation and dephosphorylation play key roles in many aspects of plant biology, including control of cell division, pathways of carbon and nitrogen metabolism, pattern formation, hormonal responses, and abiotic and biotic responses to environmental signals. A Symposium on Plant Protein Phosphorylation was hosted on the Columbia campus of the University of Missouri from May 26-28, 2010. The symposium provided an interdisciplinary venue at which scholars studying protein modification, as it relates to a broad range of biological questions and using a variety of plant species, presented their research. It also provided a forum where current international challenges in studies related to protein phosphorylation could be examined. The symposium also stimulated research collaborations through interactions and networking among those in the research community and engaged students and early career investigators in studying issues in plant biology from an interdisciplinary perspective. The proposed symposium, which drew 165 researchers from 13 countries and 21 States, facilitated a rapid dissemination of acquired knowledge and technical expertise regarding protein phosphorylation in plants to a broad range of plant biologists worldwide.

  10. Creative Literature in Canada Symposium.

    Science.gov (United States)

    Buller, Grace, Ed.; McDonough, Irma, Ed.

    The contents of this booklet were presented at a symposium on Canadian creative literature at the University of Toronto in March 1974. Included are five papers, summaries of two talks (one by Bill Sault on the oral tradition of Canada's native peoples and one by Robert Weaver on discovering and encouraging Canadian writers) and of a panel…

  11. Learning on the Job. Symposium.

    Science.gov (United States)

    2002

    This document contains two papers from a symposium on learning on the job. "Professional Crisis Workers: Impact of Repeated Exposure to Human Pain and Destructiveness" (Lynn Atkinson-Tovar) examines the following topics: (1) the secondary and vicarious traumatic stress disorder that affects many professional crisis workers who are…

  12. National symposium on food irradiation

    International Nuclear Information System (INIS)

    Beyers, M.; Brodrick, H.T.; Van Niekerk, W.C.A.

    1980-01-01

    This report contains proceedings of papers delivered at the national symposium on food irradiation held in Pretoria. The proceedings have been grouped into the following sections: general background; meat; agricultural products; marketing; and radiation facilities - cost and plant design. Each paper has been submitted separately to INIS. Tables listing irradiated food products cleared for human consumption in different countries are given

  13. Intellectual disability, coarse face, relative macrocephaly, and cerebellar hypotrophy in two sisters

    OpenAIRE

    Sousa, SB; Ramos, F; Garcia, P; Pais, RP; Paiva, C; Beales, PL; Moore, GE; Saraiva, JM; Hennekam, RC

    2014-01-01

    We report on two Portuguese sisters with a very similar phenotype characterized by severe intellectual disability, absent speech, relative macrocephaly, coarse face, cerebellar hypotrophy, and severe ataxia. Additional common features include increased thickness of the cranial vault, delayed dental eruption, talipes equino-varus, clinodactyly, and camptodactyly of the fifth finger. The older sister has retinal dystrophy and the younger sister has short stature. Their parents are consanguineou...

  14. IMPLEMENTASI SISTER PROVINCE PROVINSI JAWA TENGAH DENGAN NEGARA BAGIAN QUEENSLAND AUSTRALIA DI BIDANG PERTANIAN

    OpenAIRE

    Reni Windiani

    2016-01-01

    Globalization on national context has insisted the central government to work together and share duties and rights with the local government in order to achieve the national interest.  In Indonesia, UU 32/2004 about local government provide the chance for them to become more active in foreign policy, such as doing the cooperation in sister province/sister city program. The Central Java Province had done many sister province/sister city program with some partners aboard, such as Fujian pro...

  15. Mercury poisoning in two 13-year-old twin sisters

    Directory of Open Access Journals (Sweden)

    Ezzat Khodashenas

    2015-01-01

    Full Text Available Mercury (Hg is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. The patients were two sisters, presenting with pain in extremities, itchy rashes, sweating, salivation, weakness, and mood changes. They have used a compound that contains mercury, for treatment of pedicullosis three months before admission. This compound was purchased from a herbal shop and was applied locally on the scalps for 2 days. Their urinary mercury concentrations were 50 and 70 mg/L. They were successfully treated by D-penicillamine and gabapentin. In a patient with any kind of bone and joint pain, skin rash erythema and peripheral neuropathy, mercury poisoning should be considered as a differential diagnosis.

  16. Mothers' differential treatment of adolescent siblings: predicting college attendance of sisters versus brothers.

    Science.gov (United States)

    Bissell-Havran, Joanna M; Loken, Eric; McHale, Susan M

    2012-10-01

    Current estimates suggest that by 2015, 60% of college students will be women, a change since 1970 when 59% were men. We investigated family dynamics that might explain the growing gender gap in college attendance, focusing on an ethnically diverse sample of 522 mixed sex sibling dyads from the National Longitudinal Study of Adolescent Health. We examined whether the difference between sisters' and brothers' reports of their mothers' expectations for, and involvement in, their education during adolescence predicted their differential odds of college attendance seven years later. Sisters were more likely than brothers to attend college, and this gap was more pronounced among non-Whites and non-Asians. Sisters also had higher grades in school than their brothers. Although there were no gender differences overall in maternal educational expectations or involvement, brothers reported greater maternal involvement than sisters in non-White and non-Asian families. After controlling for family background factors, the average of siblings' reports of maternal treatment, and differences between siblings' grades, the results revealed that as sisters reported greater maternal educational expectations than their brothers, it became more likely that only the sister rather than only the brother in the family attended college. The difference between brothers' and sisters' reports of their mothers' educational involvement and their odds of attending college showed the same pattern of association but was not statistically significant. These results suggest that within-family social comparisons may play a role in sisters' and brothers' choices about attending college.

  17. Spinal involvement in Camptodactyly Arthropathy Coxa-vara Pericarditis (CACP) syndrome in two Yemeni sisters

    NARCIS (Netherlands)

    Emad, Yasser; Ragab, Yasser; Ibrahim, Osama; Khalifa, Maher; Dawood, Ahmed; Rasker, Johannes J.

    2017-01-01

    Aim of the work The objective of this clinical report is to describe the detailed magnetic resonance imaging (MRI) findings of the spine, knee and hip joints in two young sisters with Camptodactyly Arthropathy Coxa-vara Pericarditis (CACP) syndrome. Cases report In two young sisters, both had normal

  18. Test of radiation damage enhancement due to incorporation of BrUdR into DNA using chromatid aberrations

    International Nuclear Information System (INIS)

    Nikjoo, Hooshang; Savage, J.R.K.; Harvey, A.; Aghamohammadi, S.Z.; Charlton, D.E.

    1992-01-01

    Monte Carlo track structure calculations, leading to an estimation of the magnitude of enhancement of radiation damage due to the incorporation of the halogenated pyrimidine, bromodeoxyuridine (BrUdR) a thymine analog, into DNA have been made. The increase in the yield of double strand breaks for various degrees of substitution in one (monofilarly) or both strands (bifilarly) have been calculated. To test these calculations, quantitative selected radiation-induced aberrations have been obtained in Chinese hamster (V79) fibroblast chromosomes having various patterns of BrUdR substitution following irradiation with 250 kV X rays. Free ''breaks'' and achromatic lesions ''gaps'' show no appreciable sensitizations, but breaks involved in chromatid interchanges show significant enhancement though of lower magnitude than theoretical predictions

  19. Ninth international symposium on radiopharmacology

    International Nuclear Information System (INIS)

    1995-01-01

    The goal of this Symposium is to provide a forum for those international scientists involved in applying the principles of pharmacology and radiation biology to the development of agents for the diagnosis and treatment of disease. The program will highlight state-of-the-art progress in the development of those agents used in conjunction with some form of radiation such as radiopharmaceuticals, radiopaques, photo- and radiosensitizing drugs, and neutron capture agents. An underlying pharmacokinetic parameter associated with all these agents is the need for site-specific delivery to an organ or tumor. Therefore, a major goal of the symposium will be to address those pharmacologic principles for targeting molecules to specific tissue sites. Accordingly, session themes will include receptor-mediated processes, membrane transporters, antibody interactions, metabolic trapping, and oligonucleotide-antisense mechanisms

  20. Memorial Symposium for Victor Weisskopf

    CERN Multimedia

    2002-01-01

    Victor 'Viki' Weisskopf, former Director General of CERN from 1961 to 1965, passed away five months ago. At that time, the Bulletin dedicated its coverpage to this brilliant physicist (19-20/2002). Now, CERN has organised a Memorial Symposium for next Tuesday 17 September, where you are cordially invited. This tribute will include the following speechs: L. Maiani: Welcome J. D. Jackson: Highlights from the career and scientific works of Victor F. Weisskopf M. Hine and K. Johnsen: Working with Viki at CERN M. Jacob: Knowledge and Wonder A member of Viki's family: Reminiscences. The Memorial Symposium will take place in the Main Auditorium at 15h. Drinks will be served in Pas Perdus at 17h 30.

  1. Ninth international symposium on radiopharmacology

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The goal of this Symposium is to provide a forum for those international scientists involved in applying the principles of pharmacology and radiation biology to the development of agents for the diagnosis and treatment of disease. The program will highlight state-of-the-art progress in the development of those agents used in conjunction with some form of radiation such as radiopharmaceuticals, radiopaques, photo- and radiosensitizing drugs, and neutron capture agents. An underlying pharmacokinetic parameter associated with all these agents is the need for site-specific delivery to an organ or tumor. Therefore, a major goal of the symposium will be to address those pharmacologic principles for targeting molecules to specific tissue sites. Accordingly, session themes will include receptor-mediated processes, membrane transporters, antibody interactions, metabolic trapping, and oligonucleotide-antisense mechanisms.

  2. 16th International Seapower Symposium

    Science.gov (United States)

    2004-06-01

    Legal Perspective: CAPT Hayes 170 Sixteenth International Seapower Symposium Country Delegate Argentina CAPT Rafael Luis Sgueglia, Director of...CAPT Armando Jose Gomez Zapata , Head of Pacific Naval District Military Region Nigeria VADM Samuel Afolayan, Chief of the Naval Staff Panama GEN Jose...Antonio Isaza Ros, Director General of the National Maritime Service Peru RADM Luis Ramos Ormeno, Director of the Peruvian Navy War College Qatar BG

  3. Symposium 3 of JENAM 2011

    CERN Document Server

    Georgieva, Katya; Nagovitsyn, Yury; The sun : new challenges

    2012-01-01

    These are the proceedings of the Symposium 3 of JENAM 2011 on new scientific challenges posed by the Sun. The topics covered are   1. The unusual sunspot minimum, which poses challenges to the solar dynamo theory 2. The Sun’s Terra-Hertz emission, which opens a new observational window 3. Corona wave activity 4. Space weather agents - initiation, propagation, and forecasting In 21 in-depth contributions, the reader will be presented with the latest findings.

  4. Rapporteurs report of the symposium

    International Nuclear Information System (INIS)

    Myerscough, Dan

    2014-01-01

    The objective of the symposium was to share current practice, experiences and innovations within the management of contaminated metallic radioactive material. The symposium was a forum for: Learning about current practices, Highlight strategic issues related to metals recycling, Exchange of experiences, Discussion of innovative and new techniques and needs for improvements, Developing and maintenance of networks in the area of metals recycling. The aim was to bring together operators, regulators, decision makers, scientists, consultants, contractors and other stakeholders. A short introduction by representatives from Studsvik, IAEA and OECD/NEA started the symposium followed by presentations by invited speakers from international organisations. Seven topical sessions covered issues relating to: 1 - Regulations and recommendations: - International recommendations and national legislation, - Application of regulations, - Regulator views; 2 - Minimising waste amounts: - Experience in minimising the generation of waste in the form of radioactive or potentially radioactive metals, - Activities to minimise the waste volumes for disposal; 3 - Characterisation and categorisation of metals to be recycled; 4 - Decontamination of metals for clearance; 5 - Melting of metals for clearance, reuse or volume reduction; 6 - Best practice in management of metals for clearance and recycling; 7 - Sustainability and public acceptance. Each session contained three to five presentations and group discussions. Each session was concluded with a short analysis of the presentations and the outcome of the group discussions. Conclusions of each session and outcome of the group discussions were presented on a Summing up the third day. The symposium also held a poster session with topics as above. This report provides a short summary of the various presentations and discussions concentrating on the key messages and outcomes of the sessions

  5. Memorial symposium for Victor Weisskopf.

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    A memorial symposium for Victor Weisskopf, CERN Director-General from 1961 to 1965, was held at CERN on 17 September 2002. Photo 01: L. Maiani: Welcome.Photo 02: J. D. Jackson: Highlights from the career and scientific works of Victor F. Weisskopf.Photos 05 09: M. Hine and K. Johnsen: Working with Viki at CERN.Photo 10: M. Jacob: Knowledge and Wonder.Photo 14: K. Worth (Viki's daughter): Reminiscences.

  6. 26th National Neurotrauma Symposium

    Science.gov (United States)

    2008-12-31

    organizer Karen Gottlieb and her colleagues at TLC Events Group, Inc. for their incredibly competent, thorough, friendly and dedicated work in organizing...one in China . Currently there are two PRCT studies under way: DECRA (Australia) and RESCUEicp (UK). Between 10-20 percent of patients with closed...NORTH 10’ TLC - NATIONAL NEUROTRAUMA SYMPOSIUM _ JULY 27 • 29, 2008 _ HILTON IN THE WALT DISNEY WORLD RESORT LAKE BUENA VISTA. FLORIDA

  7. Symposium on Nuclear Energy. Proceedings

    International Nuclear Information System (INIS)

    1981-01-01

    The energy problem poses a big challenge to a developing country like the Philippines. The development of renewable energy sources is not enough. Aware then of the limitations of these energy sources, in spite of arguments against nuclear energy we have no other recourse but to go nuclear. This symposium emphasizes the importance of energy development to attain the country's progress and discusses the pros and economics of nuclear power. (RTD)

  8. National symposium on food irradiation

    International Nuclear Information System (INIS)

    1979-10-01

    This report contains abstracts of papers delivered at the National symposium on food irradiation held in Pretoria. The abstracts have been grouped into the following sections: General background, meat, agricultural products, marketing and radiation facilities - cost and plant design. Each abstract has been submutted separately to INIS. Tables listing irradiated food products cleared for human consumption in different countries are given as well as a table listing those irradiated food items that have been cleared in South Africa

  9. First symposium of ichthyosis experts.

    Science.gov (United States)

    Hernández-Martín, A; Torrelo-Fernández, A; de Lucas-Laguna, R; Casco, F; González-Sarmiento, R; Vega, A; Pedreira-Massa, J L; de Unamuno-Pérez, P; Larcher, F; Arroyo, I; Traupe, H

    2013-12-01

    On June 22, 2012 the First Symposium of Ichthyosis Experts in Spain was held at the Hospital Niño de Jesús in Madrid. It was a one-day symposium for dermatologists, pediatricians, and physicians-in-training interested in this disease, as well as for other health care professionals involved in the care of patients with ichthyosis. The aim of the meeting was to try to structure the care of ichthyosis patients in Spain. As happens in other rare diseases, because of the low prevalence of ichthyosis and the absence of designated referral centers, the number of patients treated in each center is very low and few dermatologists have any real clinical experience with this condition or know how to order diagnostic genetic tests. This article summarizes the presentations given at the symposium and is intended as a reference for anyone interested in the subject. Copyright © 2012 Elsevier España, S.L. and AEDV. All rights reserved.

  10. 4th International Language Management Symposium

    Czech Academy of Sciences Publication Activity Database

    Prošek, Martin

    2016-01-01

    Roč. 77, č. 3 (2016), s. 233-240 ISSN 0037-7031. [international language management symposium] Institutional support: RVO:68378092 Keywords : language management theory * international language symposium * language management Subject RIV: AI - Linguistics OBOR OECD: Linguistics Impact factor: 0.625, year: 2016

  11. Symposium on Differential Geometry and Differential Equations

    CERN Document Server

    Berger, Marcel; Bryant, Robert

    1987-01-01

    The DD6 Symposium was, like its predecessors DD1 to DD5 both a research symposium and a summer seminar and concentrated on differential geometry. This volume contains a selection of the invited papers and some additional contributions. They cover recent advances and principal trends in current research in differential geometry.

  12. Conserving biodiversity on native rangelands: Symposium proceedings

    Science.gov (United States)

    Daniel W. Uresk; Greg L. Schenbeck; James T. O' Rourke

    1997-01-01

    These proceedings are the result of a symposium, "Conserving biodiversity on native rangelands" held on August 17, 1995 in Fort Robinson State Park, NE. The purpose of this symposium was to provide a forum to discuss how elements of rangeland biodiversity are being conserved today. We asked, "How resilient and sustainable are rangeland systems to the...

  13. Proceedings of the fifth Sede Boqer symposium on solar electricity production

    International Nuclear Information System (INIS)

    Faiman, D.

    1993-02-01

    The layout of the present volume closely follows the order of the events during the symposium. First there is an in-depth review of direct steam generation technology and a vision for an international joint effort to develop solar thermal electricity technology. The second section contains reviews of the 'sister' solar technologies that are currently of interest: central receivers, specifically the Solar 2 project, and the photovoltaics, specifically an outline of solar cell development within the framework of the former Soviet Union's space program. The third section contains technical lectures on the various problems associated with the design of solar direct steam generating systems, including physics of two-phase flow. The fourth section contains presentations of the poster session. (ed.)

  14. The unforgotten sisters female astronomers and scientists before Caroline Herschel

    CERN Document Server

    Bernardi, Gabriella

    2016-01-01

    Taking inspiration from Siv Cedering’s poem in the form of a fictional letter from Caroline Herschel that refers to “my long, lost sisters, forgotten in the books that record our science”, this book tells the lives of twenty-five female scientists, with specific attention to astronomers and mathematicians. Each of the presented biographies is organized as a kind of "personal file" which sets the biographee’s life in its historical context, documents her main works, highlights some curious facts, and records citations about her. The selected figures are among the most representative of this neglected world, including such luminaries as Hypatia of Alexandra, Hildegard of Bingen, Elisabetha Hevelius, and Maria Gaetana Agnesi. They span a period of about 4000 years, from En HeduAnna, the Akkadian princess, who was one of the first recognized female astronomers, to the dawn of the era of modern astronomy with Caroline Herschel and Mary Somerville. The book will be of interest to all who wish to learn more ...

  15. Chloroplast Phylogenomics Indicates that Ginkgo biloba Is Sister to Cycads

    Science.gov (United States)

    Wu, Chung-Shien; Chaw, Shu-Miaw; Huang, Ya-Yi

    2013-01-01

    Molecular phylogenetic studies have not yet reached a consensus on the placement of Ginkgoales, which is represented by the only living species, Ginkgo biloba (common name: ginkgo). At least six discrepant placements of ginkgo have been proposed. This study aimed to use the chloroplast phylogenomic approach to examine possible factors that lead to such disagreeing placements. We found the sequence types used in the analyses as the most critical factor in the conflicting placements of ginkgo. In addition, the placement of ginkgo varied in the trees inferred from nucleotide (NU) sequences, which notably depended on breadth of taxon sampling, tree-building methods, codon positions, positions of Gnetopsida (common name: gnetophytes), and including or excluding gnetophytes in data sets. In contrast, the trees inferred from amino acid (AA) sequences congruently supported the monophyly of a ginkgo and Cycadales (common name: cycads) clade, regardless of which factors were examined. Our site-stripping analysis further revealed that the high substitution saturation of NU sequences mainly derived from the third codon positions and contributed to the variable placements of ginkgo. In summary, the factors we surveyed did not affect results inferred from analyses of AA sequences. Congruent topologies in our AA trees give more confidence in supporting the ginkgo–cycad sister-group hypothesis. PMID:23315384

  16. Benign multicystic mesothelioma: a case report of three sisters

    Directory of Open Access Journals (Sweden)

    Thomas Rutherford

    2009-12-01

    Full Text Available Benign multicystic mesothelioma (BMCM is a rare tumor of the abdomen-peritoneum of unknown etiology. This benign tumor was initially described by Plaut in 1928 when he observed loose cysts in the pelvis during a surgery for a uterine leiomyoma.2 The mesothelial origin was later confirmed by electron micro-scopy by Mennemeyer and Smith in 1979.3 To date, there are approximately 140 cases of BMCM reported in the literature.4 This disease primarily occurs in pre-menopausal women and is associated with a history of pelvic inflammatory disease, prior abdominal surgery, and endometriosis.4,5 The pathogenesis of this disease remains controversial, with possible etiologies including a neoplastic versus a reactive process.5 In the literature, a few case reports discuss a possible genetic or familial association with BMCM.6 Specifically, one report describes a man with familial Mediterranean fever who developed BMCM. Although familial Mediter-ranean fever is associated with malignant mesothelioma, he had only BMCM, and did not suffer from malignant mesothelioma.6 A genetic evaluation and chromosomal analysis were not able to identify a specific genetic cause of the family’s pattern of disease. This case report describes two female siblings diagnosed with BMCM. In addition, a third sister also had findings consistent with BMCM, however, the discrete histological diagnosis was never confirmed.

  17. Amalia, the hysteric sister (I. Svevo, Senilità, 1898

    Directory of Open Access Journals (Sweden)

    Daniela Brogi

    2013-06-01

    Full Text Available The essay is dedicated to Amalia Brentani, the sister of the protagonist of Senilità (1898, by Italo Svevo. She is, in fact, a crucial figure: because of the narrative and symbolic symmetries between the two siblings; because of the continuous expression of a desire sometimes missed, sometimes denied desire, sometimes affirmed in the form of physical and psychic discomfort. Hysteria is the main device used to develop her identity, but it is not just a theme: it becomes a real character in the plot. It hides the narrative truths unveiled by the rhetoric of the text. Amalia is not a person in flesh and bones, nor she is a real clinical case: she is a literary character born from the imagination of an author who belongs to his time, or even resambles it. In particular, it is the time when experimental psychology begins to tackle the complexity of the human soul (and therefore also of desire, first and foremost interrogating the psychophysical oddities of female nature.

  18. Ecologically distinct dinosaurian sister group shows early diversification of Ornithodira.

    Science.gov (United States)

    Nesbitt, Sterling J; Sidor, Christian A; Irmis, Randall B; Angielczyk, Kenneth D; Smith, Roger M H; Tsuji, Linda A

    2010-03-04

    The early evolutionary history of Ornithodira (avian-line archosaurs) has hitherto been documented by incomplete (Lagerpeton) or unusually specialized forms (pterosaurs and Silesaurus). Recently, a variety of Silesaurus-like taxa have been reported from the Triassic period of both Gondwana and Laurasia, but their relationships to each other and to dinosaurs remain a subject of debate. Here we report on a new avian-line archosaur from the early Middle Triassic (Anisian) of Tanzania. Phylogenetic analysis places Asilisaurus kongwe gen. et sp. nov. as an avian-line archosaur and a member of the Silesauridae, which is here considered the sister taxon to Dinosauria. Silesaurids were diverse and had a wide distribution by the Late Triassic, with a novel ornithodiran bauplan including leaf-shaped teeth, a beak-like lower jaw, long, gracile limbs, and a quadrupedal stance. Our analysis suggests that the dentition and diet of silesaurids, ornithischians and sauropodomorphs evolved independently from a plesiomorphic carnivorous form. As the oldest avian-line archosaur, Asilisaurus demonstrates the antiquity of both Ornithodira and the dinosaurian lineage. The initial diversification of Archosauria, previously documented by crocodilian-line archosaurs in the Anisian, can now be shown to include a contemporaneous avian-line radiation. The unparalleled taxonomic diversity of the Manda archosaur assemblage indicates that archosaur diversification was well underway by the Middle Triassic or earlier.

  19. The Politics of Exile: Ama Ata Aidoo's Our Sister Killjoy

    Directory of Open Access Journals (Sweden)

    Gay Wilentz

    1991-01-01

    Full Text Available Ama Ata Aidoo's Our Sister Killjoy or Reflections from a Black-Eyed Squint is a relentless attack on the notions of exile as relief from the societal constraints of national development and freedom to live in a cultural environment conducive to creativity. In this personalized prose/poem, Aidoo questions certain prescribed theories of exile (including the reasons for exile—particularly among African men. The novel exposes a rarely heard viewpoint in literature in English—that of the African woman exile. Aidoo's protagonist Sissie, as the "eye" of her people, is a sojourner in the "civilized" world of the colonizers. In this article, I examine Aidoo's challenge to prevailing theories of exile, her questioning of the supposed superiority of European culture for the colonial subject, and her exposé of the politics of exile for African self-exile. Through a combination of prose, poetry, oral voicing and letter writing, Aidoo's Sissie reports back to her home community what she sees in the land of the colonizers and confronts those exiles who have forgotten their duty to their native land.

  20. International symposium 'Energetics 2004'. Symposium proceedings. Book 2

    International Nuclear Information System (INIS)

    2004-01-01

    The holding of this Symposium was initiated by ZEMAK - Macedonian Energy Association that for the last tens of years established itself in the national and international scientific and professional circles as a competent association of professionals with the main goal to follow, promote and improve the energy sector in the country. Having in mind the fact that the power energy sector as a fundamental sector plays a main role in the development and the improvement of the rest of the industry, and in the same time has a tremendous impact on the sustainable development of the entire economy of a country, power energy sector in fact has the paramount importance in the business environment of our country. Thus, ZEMAK has historically important role as a responsible and permanent driver, promoter and initiator for resolving of all-important questions directly or indirectly interconnected with the power energy sector in the country, and therefore the entire economy in the country as well. Following the past, ZEMAK had and would always have needs of organizing national and international symposiums and workshops as a panel where directly at one place national and international power energy experts could initiate, debate and resolve all up-to-date questions in the present energy sector in Macedonia, could analyze the modern world trends in the energy sector and try to find appropriate models for their application for further development and improvement of the energy sector in our country. This international symposium has the main goal to concentrate on a single place everybody who has power energy as a permanent preoccupation and/or vocation and professional interest. To aggregate on one place various experts, from the Academy and Universities, from the business circles and companies who are preoccupied with power energy directly or indirectly in their everyday life and work. During the Symposium more than 90 scientific and/or professional papers were presented and discussed

  1. International symposium 'Energetics 2004'. Symposium proceedings. Book 1

    International Nuclear Information System (INIS)

    2004-01-01

    The holding of this Symposium was initiated by ZEMAK - Macedonian Energy Association that for the last tens of years established itself in the national and international scientific and professional circles as a competent association of professionals with the main goal to follow, promote and improve the energy sector in the country. Having in mind the fact that the power energy sector as a fundamental sector plays a main role in the development and the improvement of the rest of the industry, and in the same time has a tremendous impact on the sustainable development of the entire economy of a country, power energy sector in fact has the paramount importance in the business environment of our country. Thus, ZEMAK has historically important role as a responsible and permanent driver, promoter and initiator for resolving of all-important questions directly or indirectly interconnected with the power energy sector in the country, and therefore the entire economy in the country as well. Following the past, ZEMAK had and would always have needs of organizing national and international symposiums and workshops as a panel where directly at one place national and international power energy experts could initiate, debate and resolve all up-to-date questions in the present energy sector in Macedonia, could analyze the modern world trends in the energy sector and try to find appropriate models for their application for further development and improvement of the energy sector in our country. This international symposium has the main goal to concentrate on a single place everybody who has power energy as a permanent preoccupation and/or vocation and professional interest. To aggregate on one place various experts, from the Academy and Universities, from the business circles and companies who are preoccupied with power energy directly or indirectly in their everyday life and work. During the Symposium more than 90 scientific and/or professional papers were presented and discussed

  2. 14. European cosmic ray symposium. Symposium program and abstracts

    International Nuclear Information System (INIS)

    1994-08-01

    The abstracts of the 14. European Cosmic Ray Symposium are presented. The papers cover a large variety of topics in cosmic ray physics, both from the theoretical and the experimental point of view. Sun physics, and the effects on the inner heliosphere, the composition, and the properties of the primary and secondary cosmic radiation, galactic acceleration and the results of accelerator physics relevant to cosmic radiation physics, and the description and the results of large detector systems are presented. 63 items are indexed for INIS database. (K.A.)

  3. Intellectual disability, coarse face, relative macrocephaly, and cerebellar hypotrophy in two sisters.

    Science.gov (United States)

    Sousa, Sérgio B; Ramos, Fabiana; Garcia, Paula; Pais, Rui P; Paiva, Catarina; Beales, Philip L; Moore, Gudrun E; Saraiva, Jorge M; Hennekam, Raoul C M

    2014-01-01

    We report on two Portuguese sisters with a very similar phenotype characterized by severe intellectual disability, absent speech, relative macrocephaly, coarse face, cerebellar hypotrophy, and severe ataxia. Additional common features include increased thickness of the cranial vault, delayed dental eruption, talipes equino-varus, clinodactyly, and camptodactyly of the fifth finger. The older sister has retinal dystrophy and the younger sister has short stature. Their parents are consanguineous. We suggest this condition constitutes a previously unreported autosomal recessive entity. © 2013 Wiley Periodicals, Inc.

  4. 6th Asian Physics Symposium

    International Nuclear Information System (INIS)

    2016-01-01

    Preface: The 6th Asian Physics Symposium 2015 (APS 2015) The 6th Asian Physics Symposium 2015 (APS 2015) is organized by the Physics Department, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, in collaboration with HFI (Indonesian Physical Society), PAPSI (Physics and Applied Physics Society of Indonesia), HANI (Indonesian Nuclear Scientist Society), HRMI (Indonesian Material Research Society), HAGI (Indonesian Geophysicist Society) - West Java Chapter, and HFMBI (Indonesian Medical Physicist and Biophysicist Society). APS 2015 is aimed at providing a forum of scientific communication and interaction among distinguished scientists working in physics and its related fields. In this scientific event the latest research will be presented, and state-of-the-art developments in the field discussed, to help to guide our future research directions. It is also designed to offer the opportunity for young Indonesian scientists and students to make direct contacts with well-known scientists abroad and thereby foster the existing research collaborations and extend international research networking for the future. The scope of research presented and discussed in this symposium covers theoretical high energy physics, materials sciences and technology, biophysics and medical physics, nuclear science and engineering, earth and planetary sciences, computational physics, instrumentation and measurement, physics education, and interdisciplinary physics. The program of APS 2016 features 6 invited talks and 208 contributed oral presentations, which come from 7 different countries: Japan, South Korea, Singapore, Malaysia, Iraq, Ethiopia, and Indonesia. All papers have been reviewed after they are presented in this event. Selected papers are published in this Institute of Physics (IoP) Conference Series. Finally, I would like to express my sincere appreciation to all of authors for their valuable contributions and also to the members of the committee for

  5. Third symposium on underground mining

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-01-01

    The Third Symposium on Underground Mining was held at the Kentucky Fair and Exposition Center, Louisville, KY, October 18--20, 1977. Thirty-one papers have been entered individually into EDB and ERA. The topics covered include mining system (longwall, shortwall, room and pillar, etc.), mining equipment (continuous miners, longwall equipment, supports, roof bolters, shaft excavation equipment, monitoring and control systems. Maintenance and rebuilding facilities, lighting systems, etc.), ventilation, noise abatement, economics, accidents (cost), dust control and on-line computer systems. (LTN)

  6. International Ocean Symposium (IOS) 1996; Kokusai kaiyo symposium 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-18

    This is a proceedings of the International Ocean Symposium 1996. On the first day of the symposium, the following were given with a theme `The Ocean, Can She Save Us`: Underwater research and future of mankind as a commemorative speech; The ocean, can she save us -- trying to discover the true figure of the ocean as a keynote speech. Panel discussion was held on The global environment and the infinite potential of the ocean. On the second day, an approach was made mostly from a cultural aspect with a theme `The Ocean and the Japanese.` The following were given: Human links between east and west as a commemorative speech; The ocean and Japanese culture as a keynote speech; Civilization spanning across oceans as a panel discussion. The Japanese have been developing their individual technologies in shipbuilding, shipping, and ocean development, have been raised by Mother Ocean, and have lived together. Ocean has been supplying humans food, water, oxygen, marine routes, and even dream and hope. The environmental pollution is the result of the human greediness. It is fear and friendship between humans and ocean that can save humans and ocean.

  7. Cell-stage-specific enhancement by caffeine of the frequency of chromatid aberrations induced by X-rays in neutral ganglia of Drosophila melanogaster

    International Nuclear Information System (INIS)

    De Marco, A.; Polani, S.

    1981-01-01

    Caffeine (10 -2 M) induced a high level of chromatid aberrations in neural ganglia of third-instar larvae of Drosophila melanogaster only when it was added to cells in late G 2 and mitotic prophase. No aberrations were observed after treatment in late S-middle G 2 or C-mitosis. We observed that, in these stages, caffeine strongly increased X-ray-induced damage (500 R). This potentiation was quantitatively similar. But it involved all types of aberration after treatment in C-mitosis, and essentially isochromatid deletions and chromatid exhanges after treatment in S-G 2 . Some hypotheses are put forth to explain the possible mechanism of action of caffeine in the potentiation of X-ray-induced damage. (orig.)

  8. International partnerships and the development of a Sister Hospital Programme.

    Science.gov (United States)

    Brown, D; Rickard, G; Mustriwati, K A; Seiler, J

    2013-03-01

    Despite some progress in meeting the Millennium Development Goals, there are still major discrepancies in health service provision between developed and developing countries. Nurses are key players to improving the quality of health services. Increasingly, partnerships are being initiated between nurses of different countries to enable those working in developing countries to improve standards of clinical care. This paper describes a partnership between two major teaching hospitals: one in Indonesia and one in Australia, designed to assist in improving standards of clinical care within the Indonesian hospital. The nature of the partnership, conceptualized as a Sister Hospital Program, is described. The processes and outcomes of the pilot programme conducted in 2011 are outlined. A brief description of the methods used to gain financial support from the Northern Territory Government is provided. The programme offered a skills development programme for selected staff from Sanglah General Hospital in Bali at Royal Darwin Hospital in northern Australia. The paper uses Green's PROCEED-PRECEDE framework both to describe and evaluate the pilot programme. The skills development programme was enthusiastically evaluated by staff from both hospitals and has led to major changes in the management of patients within the Emergency Department of Sanglah General Hospital. The success of the pilot has resulted in longer-term funding by the Australian government. WIDER POLICY OUTCOMES: The partnership model described in the paper is submitted as a possible framework for others wishing to build long-term and collaborative relationships between nurses of different nations. © 2013 The Authors. International Nursing Review © 2013 International Council of Nurses.

  9. Intellectual disability, coarse face, relative macrocephaly, and cerebellar hypotrophy in two sisters

    NARCIS (Netherlands)

    Sousa, Sérgio B.; Ramos, Fabiana; Garcia, Paula; Pais, Rui P.; Paiva, Catarina; Beales, Philip L.; Moore, Gudrun E.; Saraiva, Jorge M.; Hennekam, Raoul C. M.

    2014-01-01

    We report on two Portuguese sisters with a very similar phenotype characterized by severe intellectual disability, absent speech, relative macrocephaly, coarse face, cerebellar hypotrophy, and severe ataxia. Additional common features include increased thickness of the cranial vault, delayed dental

  10. 2 SISTERS WITH MENTAL-RETARDATION, CATARACT, ATAXIA, PROGRESSIVE HEARING-LOSS, AND POLYNEUROPATHY

    NARCIS (Netherlands)

    BEGEER, JH; SCHOLTE, FA; VANESSEN, AJ

    1991-01-01

    Two sisters are described with a disorder characterised by mental retardation, congenital cataract, progressive spinocerebellar ataxia, sensorineural deafness, and signs of peripheral neuropathy. Progressive hearing loss, ataxia, and polyneuropathy became evident in the third decade. The

  11. 20 CFR 410.340 - Determination of relationship; parent, brother, or sister.

    Science.gov (United States)

    2010-04-01

    ... domiciled (see § 410.392) at the time of his death would find, under the law they would apply in determining..., brother, or sister. Where, under such law, the individual does not bear the relationship to the miner of...

  12. Catholic nursing sisters and brothers and racial justice in mid-20th-century America.

    Science.gov (United States)

    Wall, Barbra Mann

    2009-01-01

    This historical article considers nursing's work for social justice in the 1960s civil rights movement through the lens of religious sisters and brothers who advocated for racial equality. The article examines Catholic nurses' work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were linked to serious health consequences. Historical methodology is used within the framework of "bearing witness," a term often used in relation to the civil rights movement and one the sisters themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic sister and brother nurses in the mid-20th century are chronicled, including those few sister nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely.

  13. The fifth Finnish national aerosol symposium

    International Nuclear Information System (INIS)

    Mikkanen, P.; Haemeri, K.; Kauppinen, E.

    1993-01-01

    The Fifth Finnish Aerosol Symposium was held June 1-3, 1993. Symposium is jointly organized by FAAR, Aerosol Technology Group of Technical Research Centre of Finland and Helsinki University, Department of Physics. Aerosols, the suspensions of solid and liquid particles and gases, are receiving increasing importance in many areas of science and technology. These include industrial hygiene, ambient and indoor air pollution, pollution control technologies, cloud physics, nuclear safety engineering, combustion science and engineering, clean manufacturing technologies and material processing. The importance of aerosol issues during the development of advanced fuel conversion and material processing technologies can be realized when looking at the numerous papers presented on these topics at the Symposium

  14. 6{sup th} interventional MRI symposium. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The ongoing progress in the field of interventional MRI and the great success of our last symposium 2004 in Boston have stimulated us to organize the 6th Interventional MRI Symposium to be held September 15-16, 2006 in Leipzig. This meeting will highlight ground-breaking research as well as cutting-edge reports from many groups. The symposium also provides a forum to network with leaders and innovators in the field. Session topics are: intraoperative MRI, vascular applications, targeted drug delivery, cryotherapy, thermometry, pulse sequences, LITT, percutaneous procedures, navigation, robotics, focused ultrasound. (uke)

  15. 6th interventional MRI symposium. Abstracts

    International Nuclear Information System (INIS)

    2006-01-01

    The ongoing progress in the field of interventional MRI and the great success of our last symposium 2004 in Boston have stimulated us to organize the 6th Interventional MRI Symposium to be held September 15-16, 2006 in Leipzig. This meeting will highlight ground-breaking research as well as cutting-edge reports from many groups. The symposium also provides a forum to network with leaders and innovators in the field. Session topics are: intraoperative MRI, vascular applications, targeted drug delivery, cryotherapy, thermometry, pulse sequences, LITT, percutaneous procedures, navigation, robotics, focused ultrasound. (uke)

  16. Do brothers and sisters of siblings with intelectual disability need the support of social work?

    OpenAIRE

    Cardová, Michaela

    2007-01-01

    This thesis explores the experience and support needs of siblings with a brother or sister with intellectual disability. Through review of what is a quite limited literature and from original qualitative research, involving interviews with siblings, the author examines their social reality, focusing especially on their relationships with their disabled brother or sister and with the wider society. Particular attention is given to identifying to what extent the siblings' lives are influenced b...

  17. Annual Symposium in Electronics Packaging

    CERN Document Server

    1991-01-01

    Each May, the Continuing Education Division of the T.J.Watson School of Engineering, Applied Science and Technology at the State University of New York at Binghamton sponsors an Annual Symposium in Electronics Packaging in cooperation with local professional societies (IEEE, ASME, SME, IEPS) and UnlPEG (the University-Industry Partnership for Economic Growth.) Each volume of this Electronics Packaging Forum series is based on the the preceding Symposium, with Volume Two based on the 1990 presentations. The Preface to Volume One included a brief definition of the broad scope of the electronics packaging field with some comments on why it has recently assumed such a more prominent priority for research and development. Those remarks will not be repeated here; at this point it is assumed that the reader is a professional in the packaging field, or possibly a student of one of the many academic disciplines which contribute to it. It is worthwhile repeating the series objectives, however, so the reader will be cle...

  18. Genomic data do not support comb jellies as the sister group to all other animals.

    Science.gov (United States)

    Pisani, Davide; Pett, Walker; Dohrmann, Martin; Feuda, Roberto; Rota-Stabelli, Omar; Philippe, Hervé; Lartillot, Nicolas; Wörheide, Gert

    2015-12-15

    Understanding how complex traits, such as epithelia, nervous systems, muscles, or guts, originated depends on a well-supported hypothesis about the phylogenetic relationships among major animal lineages. Traditionally, sponges (Porifera) have been interpreted as the sister group to the remaining animals, a hypothesis consistent with the conventional view that the last common animal ancestor was relatively simple and more complex body plans arose later in evolution. However, this premise has recently been challenged by analyses of the genomes of comb jellies (Ctenophora), which, instead, found ctenophores as the sister group to the remaining animals (the "Ctenophora-sister" hypothesis). Because ctenophores are morphologically complex predators with true epithelia, nervous systems, muscles, and guts, this scenario implies these traits were either present in the last common ancestor of all animals and were lost secondarily in sponges and placozoans (Trichoplax) or, alternatively, evolved convergently in comb jellies. Here, we analyze representative datasets from recent studies supporting Ctenophora-sister, including genome-scale alignments of concatenated protein sequences, as well as a genomic gene content dataset. We found no support for Ctenophora-sister and conclude it is an artifact resulting from inadequate methodology, especially the use of simplistic evolutionary models and inappropriate choice of species to root the metazoan tree. Our results reinforce a traditional scenario for the evolution of complexity in animals, and indicate that inferences about the evolution of Metazoa based on the Ctenophora-sister hypothesis are not supported by the currently available data.

  19. The 8th Japan Bioanalysis Forum symposium.

    Science.gov (United States)

    Matsumaru, Takehisa

    2017-11-01

    The 8th Japan Bioanalysis Forum symposium, the Tower Hall Funabori, Tokyo, Japan, 8-9 February 2017 The 8th Japan Bioanalysis Forum (JBF) symposium was successfully held between 8 and 9 February 2017 at the Tower Hall Funabori, Tokyo, Japan. In total, 24 speakers from Japan, USA and Europe gave presentations regarding the immunogenicity of biopharmaceuticals, ICH S3A Q&A microsampling, ICH M10 bioanalytical method validation, large molecule analysis through LC-MS, auditing activities for bioanalysis and biomarker bioanalysis. Achievements regarding eight diverse themes were also shared by Japan Bioanalysis Forum discussion groups. Over 300 scientists from regulatory agencies, industry and academia actively took part in discussions during the symposium. This article provides the highlights of all the topics discussed in this symposium.

  20. Symposium on unsaturated flow and transport modeling

    Energy Technology Data Exchange (ETDEWEB)

    Arnold, E.M.; Gee, G.W.; Nelson, R.W. (eds.)

    1982-09-01

    This document records the proceedings of a symposium on flow and transport processes in partially saturated groundwater systems, conducted at the Battelle Seattle Research Center on March 22-24, 1982. The symposium was sponsored by the US Nuclear Regulatory Commission for the purpose of assessing the state-of-the-art of flow and transport modeling for use in licensing low-level nuclear waste repositories in partially saturated zones. The first day of the symposium centered around research in flow through partially saturated systems. Papers were presented with the opportunity for questions following each presentation. In addition, after all the talks, a formal panel discussion was held during which written questions were addressed to the panel of the days speakers. The second day of the Symposium was devoted to solute and contaminant transport in partially saturated media in an identical format. Individual papers are abstracted.

  1. Proceedings of the 1994 nuclear simulation symposium

    International Nuclear Information System (INIS)

    Laughton, P.J.

    1994-01-01

    This symposium on nuclear simulation included sessions on reactor physics, on thermalhydraulics, and on fuel and fuel channels of CANDU type reactors. The individual papers have all been abstracted separately

  2. CUBE (Computer Use By Engineers) symposium abstracts

    International Nuclear Information System (INIS)

    Ruminer, J.J.

    1978-07-01

    This report presents the abstracts for the CUBE (Computer Use by Engineers) Symposium, October 4, through 6, 1978. Contributors are from Lawrence Livermore Laboratory, Los Alamos Scientific Laboratory, and Sandia Laboratories

  3. Symposium on high spin phenomena in nuclei

    International Nuclear Information System (INIS)

    1979-10-01

    Separate abstracts were prepared for 44 of the papers given at this symposium. Six other papers have already been cited in ERA; these papers can be located by reference to the entry CONF-790323 - in the Report Number Index

  4. The 2002 Starting Artificial Intelligence Researchers Symposium

    OpenAIRE

    Vidal, Thierry

    2003-01-01

    During the 2002 European Conference on Artificial Intelligence (ECAI-02) was introduced the Starting Artificial Intelligence Researchers Symposium STAIRS), the first-ever international symposium specifically aimed at Ph.D. students in AI. The outcome was a thorough, high-quality, and successful event, with all the features one usually finds in the best international conferences: large international committees, comprehensive coverage, published proceedings, renowned speakers and panelists, sub...

  5. Flight Mechanics/Estimation Theory Symposium 1995

    Science.gov (United States)

    Hartman, Kathy R. (Editor)

    1995-01-01

    This conference publication includes 41 papers and abstracts presented at the Flight Mechanics/ Estimation Theory Symposium on May 16-18, 1995. Sponsored by the Flight Dynamics Division of Goddard Space Flight Center, this symposium featured technical papers on a wide range of issues related to orbit-attitude prediction, determination, and control; attitude sensor calibration; attitude determination error analysis; attitude dynamics; and orbit decay and maneuver strategy. Government, industry, and the academic community participated in the preparation and presentation of these papers.

  6. Flight Mechanics/Estimation Theory Symposium 1996

    Science.gov (United States)

    Greatorex, Scott (Editor)

    1996-01-01

    This conference publication includes 34 papers and abstracts presented at the Flight Mechanics/ Estimation Theory Symposium on May 14-16, 1996. Sponsored by the Flight Dynamics Division of Goddard Space Flight Center, this symposium featured technical papers on a wide range of issues related to orbit-attitude prediction, determination, and control; attitude sensor calibration; attitude determination error analysis; attitude dynamics; and orbit decay and maneuver strategy. Government, industry, and the academic community participated in the preparation and presentation of these papers.

  7. XXXIX Symposium on Nuclear Physics

    International Nuclear Information System (INIS)

    Acosta, Luis; Bijker, Roelof

    2016-01-01

    In the present volume of Journal of Physics: Conference Series we publish the proceedings of the “XXXIX Symposium on Nuclear Physics”, that was held from January 5-8, 2016 at the Hacienda Cocoyoc, Morelos, Mexico. The proceedings consist of 20 contributions that were presented as plenary talks at the meeting. The abstracts of all contributions, invited talks and posters, were published in the Conference Handbook. The Symposium on Nuclear Physics has a long and distinguished history. From the beginning it was intended to be a relatively small meeting designed to bring together some of the leading nuclear scientists in the field. Its most distinctive feature is to provide a forum for specialists in different areas of nuclear physics, both theorists and experimentalists, students, postdocs and senior scientists, in a relaxed and informal environment providing them with a unique opportunity to exchange ideas. After the first meeting in Oaxtepec in 1978, the Symposium was organized every year without interruption which makes the present one the 39th in a row. The scientific program consisted of 29 invited talks and a poster session on a wide variety of hot topics in contemporary nuclear physics, ranging from the traditional fields of nuclear structure and nuclear reactions to radioactive beams, nuclear astrophysics, hadronic physics, fundamental symmetries and relativistic heavy ions, as well as progress reports of large international projects like the HAWC Observatory in Puebla, Mexico, and the ATLAS and ALICE Collaborations of the LHC accelerator at CERN, Switzerland. In addition, there were several contributions highlighting interesting new results from foreign laboratories like Notre Dame, RIKEN, Jefferson Lab, Oak Ridge, INFN-Legnaro and INFN-LNS, as well as Mexican laboratories at ININ, LEMA and the Carlos Graef Laboratory at IF-UNAM. On the theoretical side there were talks on recent developments in nuclear structure, weakly bound nuclei, cluster models

  8. Proceedings of the TOUGH Symposium 2009

    Energy Technology Data Exchange (ETDEWEB)

    Moridis, George J.; Doughty, Christine; Finsterle, Stefan; Sonnenthal, Eric

    2009-10-01

    Welcome to the TOUGH Symposium 2009. Within this volume are the Symposium Program for eighty-nine papers to be presented in both oral and poster formats. The full papers are available as pdfs linked from the Symposium Program posted on the TOUGH Symposium 2009 website http://esd.lbl.gov/newsandevents/events/toughsymposium09/program.html Additional updated information including any changes to the Program will also be available at the website. The papers cover a wide range of application areas and reflect the continuing trend toward increased sophistication of the TOUGH codes. A CD containing the proceedings papers will be published immediately following the Symposium and sent to all participants. As in the prior Symposium, selected papers will be invited for submission to a number of journals for inclusion in Special Issues focused on applications and developments of the TOUGH codes. These journals include, Transport in Porous Media, Geothermics, Energy Conversion and Management, Journal of Nuclear Science and Technology, and the Vadose Zone Journal.

  9. Symposium on Operations Research <6, 1981, Augsburg>: 6. Symposium über Operations Research

    OpenAIRE

    Bamberg, Günter

    1981-01-01

    Symposium on Operations Research : 6. Symposium über Operations Research : Univ. Augsburg, Sept. 7-9, 1981 / ed. by Günter Bamberg ... - Pt. 1-2. - Königstein/Ts. : Verl.-Gruppe Athenäum ..., 1981. - XXI, 468, 695 S. - (Methods of operations research ; 43.44)

  10. IVF for premature ovarian failure: first reported births using oocytes donated from a twin sister.

    LENUS (Irish Health Repository)

    Sills, Eric Scott

    2010-01-01

    BACKGROUND: Premature ovarian failure (POF) remains a clinically challenging entity because in vitro fertilisation (IVF) with donor oocytes is currently the only treatment known to be effective. METHODS: A 33 year-old nulligravid patient with a normal karyotype was diagnosed with POF; she had a history of failed fertility treatments and had an elevated serum FSH (42 mIU\\/ml). Oocytes donated by her dizygotic twin sister were used for IVF. The donor had already completed a successful pregnancy herself and subsequently produced a total of 10 oocytes after a combined FSH\\/LH superovulation regime. These eggs were fertilised with sperm from the recipient\\'s husband via intracytoplasmic injection and two fresh embryos were transferred to the recipient on day three. RESULTS: A healthy twin pregnancy resulted from IVF; two boys were delivered by caesarean section at 39 weeks\\' gestation. Additionally, four embryos were cryopreserved for the recipient\\'s future use. The sister-donor achieved another natural pregnancy six months after oocyte retrieval, resulting in a healthy singleton delivery. CONCLUSION: POF is believed to affect approximately 1% of reproductive age females, and POF patients with a sister who can be an oocyte donor for IVF are rare. Most such IVF patients will conceive from treatment using oocytes from an anonymous oocyte donor. This is the first report of births following sister-donor oocyte IVF in Ireland. Indeed, while sister-donor IVF has been successfully undertaken by IVF units elsewhere, this is the only known case where oocyte donation involved twin sisters. As with all types of donor gamete therapy, pre-treatment counselling is important in the circumstance of sister oocyte donation.

  11. IVF for premature ovarian failure: first reported births using oocytes donated from a twin sister

    Directory of Open Access Journals (Sweden)

    Sills Eric

    2010-03-01

    Full Text Available Abstract Background Premature ovarian failure (POF remains a clinically challenging entity because in vitro fertilisation (IVF with donor oocytes is currently the only treatment known to be effective. Methods A 33 year-old nulligravid patient with a normal karyotype was diagnosed with POF; she had a history of failed fertility treatments and had an elevated serum FSH (42 mIU/ml. Oocytes donated by her dizygotic twin sister were used for IVF. The donor had already completed a successful pregnancy herself and subsequently produced a total of 10 oocytes after a combined FSH/LH superovulation regime. These eggs were fertilised with sperm from the recipient's husband via intracytoplasmic injection and two fresh embryos were transferred to the recipient on day three. Results A healthy twin pregnancy resulted from IVF; two boys were delivered by caesarean section at 39 weeks' gestation. Additionally, four embryos were cryopreserved for the recipient's future use. The sister-donor achieved another natural pregnancy six months after oocyte retrieval, resulting in a healthy singleton delivery. Conclusion POF is believed to affect approximately 1% of reproductive age females, and POF patients with a sister who can be an oocyte donor for IVF are rare. Most such IVF patients will conceive from treatment using oocytes from an anonymous oocyte donor. This is the first report of births following sister-donor oocyte IVF in Ireland. Indeed, while sister-donor IVF has been successfully undertaken by IVF units elsewhere, this is the only known case where oocyte donation involved twin sisters. As with all types of donor gamete therapy, pre-treatment counselling is important in the circumstance of sister oocyte donation.

  12. 3. international chimney design symposium

    International Nuclear Information System (INIS)

    1979-01-01

    On the 25th and 26th of october 1978, the 3rd International Chimney Design Symposium took place in the Technical University of Munich. About 200 german and 150 foreign experts in chimney design came to participate in the lectures and debates. The deliberations focussed on the scientific aspect and the technical completion of industrial chimneys, considering all the problems which are implied in the planifaction and construction of the foundation, the shaft, and the lining of the chimney. Being one of the main topics, the possibilities of using chimneys in their waste gas eliminating function within the framework of environmental control were discussed thoroughly. Standardization on national and international level was another topic at this conference. Considerable progress has been achieved in the field of security and economy. (orig./RW) [de

  13. Symposium on accelerator mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-01-01

    The area of accelerator mass spectrometry has expanded considerably over the past few years and established itself as an independent and interdisciplinary research field. Three years have passed since the first meeting was held at Rochester. A Symposium on Accelerator Mass Spectrometry was held at Argonne on May 11-13, 1981. In attendance were 96 scientists of whom 26 were from outside the United States. The present proceedings document the program and excitement of the field. Papers are arranged according to the original program. A few papers not presented at the meeting have been added to complete the information on the status of accelerator mass spectrometry. Individual papers were prepared separately for the data base.

  14. Interdisciplinary Symposium on Complex Systems

    CERN Document Server

    Rössler, Otto; Zelinka, Ivan

    2015-01-01

    The book you hold in your hands is the outcome of the “2014 Interdisciplinary Symposium on Complex Systems” held in the historical city of Florence. The book consists of 37 chapters from 4 areas of Physical Modeling of Complex Systems, Evolutionary Computations, Complex Biological Systems and Complex Networks. All 4 parts contain contributions that give interesting point of view on complexity in different areas in science and technology. The book starts with a comprehensive overview and classification of complexity problems entitled Physics in the world of ideas: Complexity as Energy”  , followed by chapters about complexity measures and physical principles, its observation, modeling and its applications, to solving various problems including real-life applications. Further chapters contain recent research about evolution, randomness and complexity, as well as complexity in biological systems and complex networks. All selected papers represent innovative ideas, philosophical overviews and state-of-the-...

  15. Symposium on accelerator mass spectrometry

    International Nuclear Information System (INIS)

    1981-01-01

    The area of accelerator mass spectrometry has expanded considerably over the past few years and established itself as an independent and interdisciplinary research field. Three years have passed since the first meeting was held at Rochester. A Symposium on Accelerator Mass Spectrometry was held at Argonne on May 11-13, 1981. In attendance were 96 scientists of whom 26 were from outside the United States. The present proceedings document the program and excitement of the field. Papers are arranged according to the original program. A few papers not presented at the meeting have been added to complete the information on the status of accelerator mass spectrometry. Individual papers were prepared separately for the data base

  16. International waste-management symposium

    International Nuclear Information System (INIS)

    Shoup, R.L.

    1977-01-01

    An International Symposium on the Management of Wastes from the LWR Fuel Cycle was held in Denver, Colo., on July 11 to 16, 1976. The symposium covered a broad range of topics, from policy issues to technology. Presentations were made by national and international speakers involved in all aspects of waste management, government and agency officials; laboratory managers, directors, and researchers; and industrial representatives. Many speakers advocated pragmatic action on programs for the management of commercial nuclear wastes to complete the light-water reactor (LWR) fuel cycle. The industrialized nations' demand for increasing supplies of energy and their increasing dependence on nuclear energy to fulfill this demand will necessitate the development of an acceptable solution to the disposal of nuclear wastes within the next decade for some industrial nations. Waste-disposal technology should be implemented on a commercial scale, but the commercialization must be accompanied by the decision to use the technology. An important issue in the use of nuclear energy is the question of sharing the technology with the less industrialized nations and with nations that may not have suitable means to dispose of nuclear wastes. The establishment of international and multinational cooperation will be an important key in realizing this objective. Pressing issues that international organizations or task groups will have to address are ocean disposal, plutonium recycling and safeguards, and disposal criteria. The importance of achieving a viable waste-management program is made evident by the increased funding and attention that the back end of the fuel cycle is now receiving

  17. World Population Day special symposium.

    Science.gov (United States)

    1998-08-01

    This article describes Japan's celebration of World Population Day, and provides excerpts from speeches at the symposium held on July 8, 1998. The symposium, in Tokyo, was attended by about 300 people. The Chairman of JOICFP gave the opening address. The executive director of UNFPA congratulated Japan for its efforts in the field of population awareness and noted Japan's self-sufficiency despite its importation of 40% of its food and most of its raw materials. A keynote address was delivered by the president of CPE and the former UN Secretary General, who stressed income inequities in the 66% of developing countries within the 185 UN member states. The UN has been promoting sustainable development, but is facing the issue of limited arable land and population growth. The Tutsi and Hutus are fighting due to population based issues. The emphasis should be on women's reproductive rights and protection of women's human rights. 1998 is the 50th year of human rights; progress has been made. The UNFPA Goodwill Ambassador spoke about the disparity between the rich and poor in the Philippines. A small donation reaps incredible progress. Manila has high levels of adolescent childbearing. Men appear to be unaware of the disadvantages of childbearing too early. Rural areas are dominated by strict Roman Catholic beliefs. Manila has commercial sex workers who provide services to Japanese men. The 1998 Kato Award was given to women who raised awareness about coercion in the sex trade and female genital mutilation. The economic situation in Japan creates even greater need to promote family planning and reproductive health.

  18. Introduction and Overview of the Symposium Anil Kumar (Indian ...

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Introduction and Overview of the Symposium Anil Kumar (Indian Institute of Science, Bangalore). Symposium on Quantum Computing and Quantum Information. Notes:

  19. [Analysis of genomic copy number variations in two sisters with primary amenorrhea and hyperandrogenism].

    Science.gov (United States)

    Zhang, Yanliang; Xu, Qiuyue; Cai, Xuemei; Li, Yixun; Song, Guibo; Wang, Juan; Zhang, Rongchen; Dai, Yong; Duan, Yong

    2015-12-01

    To analyze genomic copy number variations (CNVs) in two sisters with primary amenorrhea and hyperandrogenism. G-banding was performed for karyotype analysis. The whole genome of the two sisters were scanned and analyzed by array-based comparative genomic hybridization (array-CGH). The results were confirmed with real-time quantitative PCR (RT-qPCR). No abnormality was found by conventional G-banded chromosome analysis. Array-CGH has identified 11 identical CNVs from the sisters which, however, overlapped with CNVs reported by the Database of Genomic Variants (http://projects.tcag.ca/variation/). Therefore, they are likely to be benign. In addition, a -8.44 Mb 9p11.1-p13.1 duplication (38,561,587-47,002,387 bp, hg18) and a -80.9 kb 4q13.2 deletion (70,183,990-70,264,889 bp, hg18) were also detected in the elder and younger sister, respectively. The relationship between such CNVs and primary amenorrhea and hyperandrogenism was however uncertain. RT-qPCR results were in accordance with array-CGH. Two CNVs were detected in two sisters by array-CGH, for which further studies are needed to clarify their correlation with primary amenorrhea and hyperandrogenism.

  20. Links between sisters' sexual and dating victimization: the roles of neighborhood crime and parental controls.

    Science.gov (United States)

    East, Patricia L; Chien, Nina C; Adams, Joyce A; Hokoda, Audrey; Maier, Ashley

    2010-12-01

    This study examined the extent to which a sister's prior sexual and dating victimization is a risk factor for young women being similarly victimized and the possible factors underlying a co-occurrence. The sample involved 122 young adult Latina or African American sister pairs (244 women; ages 16-25) who resided in low-income, urban neighborhoods. Results indicated that women whose sisters had been victimized had increased risk of victimization even after controlling for neighborhood crime, parental controls, age and race-ethnicity (odds ratios were 4.0 for unwanted touching, 6.2 for a forced sex act, and 16.7 for dating violence). In high-crime neighborhoods, the presence of two adult parent figures in the home was associated with women's reduced likelihood of unwanted touching, and mothers' high monitoring during adolescence was associated with women's lower risk of dating aggression. Survival analysis results showed that the risk period of a second sister being victimized lasts between 7 and 10 years after a first sister's victimization. The prevention implications of study findings are discussed.

  1. Using a sibling design to compare childhood adversities in female patients with BPD and their sisters.

    Science.gov (United States)

    Laporte, Lise; Paris, Joel; Guttman, Herta; Russell, Jennifer; Correa, José A

    2012-11-01

    Abuse and neglect are well-established risk correlates of borderline personality disorder (BPD). The goal of this study was to examine whether BPD probands can be differentiated from their sisters with respect to a range of developmental adversity and maltreatment indicators, including retrospective self-reports of past experiences of childhood abuse and neglect, dysfunctional parent-child relationships and peer victimization and dysfunctional peer relationships. A total of 53 patients with BPD were compared to 53 sisters who were currently free of psychopathology on measures assessing childhood adversities. Both probands and sisters reported similar prevalence of intrafamilial abuse, although BPD patients reported more severe physical and emotional abuse. BPD patients reported higher prevalence of physical abuse by peers. These findings generally support the principle of multifinality, in which similar histories of adversities can be associated with a variety of outcomes, ranging from psychopathology to resilience.

  2. Symposium Fallkonferenz Integrative Medizin [Symposium Case Conference on Integrative Medicine

    Directory of Open Access Journals (Sweden)

    Scheffer, Christian

    2007-02-01

    Full Text Available [english] Complementary and Alternative Medicine (CAM is highly requested by patients. Therefore, medical students have to be prepared and educated for this situation. We report about the first Case Conference on Integrative Medicine under the auspices of the president of the German Medical Association. In contrast to often-occurring polemic and polarizing discussions the dialog was characterized by serious and open-minded contributions in order to find the best therapeutic concept for patients. The authors suggest to establish a committee of the Gesellschaft für Medizinische Ausbildung (GMA to work on key questions in this field. Possible topics and questions are listed. [german] Vor dem Hintergrund der weiten Verbreitung von Komplementär- und Alternativmedizin (CAM und dem Bedarf einer Vorbereitung und Ausbildung der Medizinstudierenden auf dem Umgang mit CAM wird im folgenden von der ersten Fallkonferenz Integrative Medizin unter Schirmherrschaft des Bundesärztekammerpräsidenten berichtet. Statt der sonst bei dieser Thematik häufig anzutreffenden Polarisierung und Polemisierung war die Atmosphäre bei diesem Symposium geprägt von Dialogbereitschaft und dem gemeinsamen Bemühen um eine patientengerechte Integrative Medizin. Die Autoren schlagen vor, für die in diesem Zusammenhang noch völlig unbearbeiteten Ausbildungsfragen einen Ausschuss der Gesellschaft für Medizinische Ausbildung (GMA zu gründen. Mögliche Themen und Arbeitsfelder werden dargestellt.

  3. The 12th International Symposium on Spermatology

    Science.gov (United States)

    Aitken, R John; Cummins, Jim M; Nixon, Brett

    2015-01-01

    The 12th International Symposium of Spermatology continued the excellent tradition of this meeting since its inception in 1969 when the first Symposium was held in Italy under the Chairmanship of Professor Baccio Baccetti. This unique Symposium is held every 4 years and serves as a beacon for sperm cell biologists from all over the world, regardless of which species, animal or plant, they are working on. This willingness to embrace the fundamental biology of this distinctive cell type without species limitations is one of the hallmarks of this Symposium. For sperm biologists – it is our Olympics. The meeting in Newcastle, NSW brought together around 300 biologists from more than 22 different countries covering North and South America, Africa, Europe, Asia and Australia. Given the considerable distances and high cost involved in travelling to the East Coast of NSW, this was an outstanding outcome. The Symposium featured a series of 31 plenary lectures culminating in the prestigious Thaddeus Mann Memorial Lecture, which was delivered with typical grace and brilliance by Professor Masaru Okabe. PMID:25994646

  4. Proceedings of the symposium on networking

    International Nuclear Information System (INIS)

    Karita, Yukio; Abe, Fumio

    1989-06-01

    The first symposium on networking was held on February 6-7, 1989. Due to the increase of the needs of computer networks, several networks which connect among universities and laboratories are going to be constructed in Japan. However, the techniques in networking are not familiar to most people, and the information about these techniques is sometimes difficult to get, especially in multivendor connection. In such situation, an opportunity to hold a symposium on networking at the National Laboratory for High Energy Physics (KEK) was given. More than 200 people took part in this symposium, and the local area networks in institutions, the networks among institutions, the networks for high energy physics, the application of networks, the networks for academic research and so on are reported. The valuable discussion about networks was carried out, including the plans for near future. At the time of this symposium, the construction of the Gakujo-net and the Pacific network project of University of Hawaii were in progress, and many Japanese universities are going to construct their campus LANs, so the symposium seemed to be very timely. (K.I.)

  5. RecA bundles mediate homology pairing between distant sisters during DNA break repair

    Science.gov (United States)

    Lesterlin, Christian; Ball, Graeme; Schermelleh, Lothar; Sherratt, David J.

    2014-02-01

    DNA double-strand break (DSB) repair by homologous recombination has evolved to maintain genetic integrity in all organisms. Although many reactions that occur during homologous recombination are known, it is unclear where, when and how they occur in cells. Here, by using conventional and super-resolution microscopy, we describe the progression of DSB repair in live Escherichia coli. Specifically, we investigate whether homologous recombination can occur efficiently between distant sister loci that have segregated to opposite halves of an E. coli cell. We show that a site-specific DSB in one sister can be repaired efficiently using distant sister homology. After RecBCD processing of the DSB, RecA is recruited to the cut locus, where it nucleates into a bundle that contains many more RecA molecules than can associate with the two single-stranded DNA regions that form at the DSB. Mature bundles extend along the long axis of the cell, in the space between the bulk nucleoid and the inner membrane. Bundle formation is followed by pairing, in which the two ends of the cut locus relocate at the periphery of the nucleoid and together move rapidly towards the homology of the uncut sister. After sister locus pairing, RecA bundles disassemble and proteins that act late in homologous recombination are recruited to give viable recombinants 1-2-generation-time equivalents after formation of the initial DSB. Mutated RecA proteins that do not form bundles are defective in sister pairing and in DSB-induced repair. This work reveals an unanticipated role of RecA bundles in channelling the movement of the DNA DSB ends, thereby facilitating the long-range homology search that occurs before the strand invasion and transfer reactions.

  6. 7th International Fermi Symposium

    Science.gov (United States)

    2017-10-01

    especially encourage guest investigators worldwide to participate in this symposium to share results and to learn about upcoming opportunities. This meeting will focus on the new scientific investigations and results enabled by Fermi, the mission and instrument characteristics, future opportunities, coordinated observations and analysis techniques. In particular, we also encourage discussion of future prospects/science with Fermi in preparation for the upcoming NASA senior review. Details on the 7th International Fermi Symposium can be found here: https://events.mpe.mpg.de/Fermi2017

  7. IMPLEMENTASI SISTER PROVINCE PROVINSI JAWA TENGAH DENGAN NEGARA BAGIAN QUEENSLAND AUSTRALIA DI BIDANG PERTANIAN

    Directory of Open Access Journals (Sweden)

    Reni Windiani

    2016-02-01

    Full Text Available Globalization on national context has insisted the central government to work together and share duties and rights with the local government in order to achieve the national interest.  In Indonesia, UU 32/2004 about local government provide the chance for them to become more active in foreign policy, such as doing the cooperation in sister province/sister city program. The Central Java Province had done many sister province/sister city program with some partners aboard, such as Fujian province (China, Chungchoeng buk-do province (South Korea and the Queensland province (Australia.  The cooperation cover many sectors such as agriculture, city and village development, transportation and tourism, industry, trade and infestation, education, science and technology, and other sectors that will be confer in advance. From all of the cooperation that have been done between Central Java Province and Queensland, the author, is interested to have research on farming, because central government has had many cows imported from Australia.  This research is become important because central java province is one of the major of national fresh meat distributors. This research is using a qualitative method, with descriptive type of research.  This research has three research questions: How effective is the Sister Province program in Central Java with the Queensland in farm sector? What is the obstacle that holds the Sister Province program in Central Java with the Queensland in farm sector? How is the prospect of Sister Province program in Central Java with the Queensland in farm sector? This result of this research is to prove that the implementation of Sister Province program in Central Java with the Queensland in farm sectors is not effective.  Some of the implementation variables of this program have not been fulfilled. Communication, financial resources and bureaucracy structure are some of the variables that have weakness on this program.  Act of

  8. Ukrainian and European Baroque in the Context of “Sister Arts” Idea

    Directory of Open Access Journals (Sweden)

    Olga Shikirinskaya

    2015-08-01

    Full Text Available The article deals with the “Sister Arts” tradition as the interrelationship of various art forms (poetry, fiction, painting, theatre, music etc. relative to the Baroque period. “Sister Arts” criticism, based on E.G. Lessing essay “Laocoön…” uses the inter-art analogies to appreciate the importance of literature in the Arts, as well as to comprehend aspects of the modern approach to the synthesis of the arts. The article presents the aesthetic concept of Baroque art and its realization in architecture, sculpture, decorative and applied arts, music and literature on the background of the European and Ukrainian cultural tradition.

  9. 28th International Symposium on Shock Waves

    CERN Document Server

    2012-01-01

    The University of Manchester hosted the 28th International Symposium on Shock Waves between 17 and 22 July 2011. The International Symposium on Shock Waves first took place in 1957 in Boston and has since become an internationally acclaimed series of meetings for the wider Shock Wave Community. The ISSW28 focused on the following areas: Blast Waves, Chemically Reacting Flows, Dense Gases and Rarefied Flows, Detonation and Combustion, Diagnostics, Facilities, Flow Visualisation, Hypersonic Flow, Ignition, Impact and Compaction, Multiphase Flow, Nozzle Flow, Numerical Methods, Propulsion, Richtmyer-Meshkov, Shockwave Boundary Layer Interaction, Shock Propagation and Reflection, Shock Vortex Interaction, Shockwave Phenomena and Applications, as well as Medical and Biological Applications. The two Volumes contain the papers presented at the symposium and serve as a reference for the participants of the ISSW 28 and individuals interested in these fields.

  10. 6th International Symposium on Thermal Expansion

    CERN Document Server

    1978-01-01

    This 6th International Symposium on Thermal Expansion, the first outside the USA, was held on August 29-31, 1977 at the Gull Harbour Resort on Hecla Island, Manitoba, Canada. Symposium Chairman was Ian D. Peggs, Atomic Energy of Canada Limited, and our continuing sponsor was CINDAS/Purdue University. We made considerable efforts to broaden the base this year to include more users of expansion data but with little success. We were successful, however, in establishing a session on liquids, an area which is receiving more attention as a logical extension to the high-speed thermophysical property measurements on materials at temperatures close to their melting points. The Symposium had good international representation but the overall attendance was, disappointingly, relatively low. Neverthe­ less, this enhanced the informal atmosphere throughout the meeting with a resultant frank exchange of information and ideas which all attendees appreciated. A totally new item this year was the presentation of a bursary to ...

  11. Proceedings of the second ERDA statistical symposium

    Energy Technology Data Exchange (ETDEWEB)

    Tietjen, G.; Campbell, K. (comps.)

    1977-04-01

    The Second ERDA Statistical Symposium, sponsored by the Energy Research and Development Administration, was held at Oak Ridge, Tennessee, October 25-27, 1976. This was the second annual symposium designed to promote interlaboratory communications among ERDA statisticians as well as contacts with statisticians from other institutions. The proceedings of the first symposium, held at Los Alamos in November, 1975, have been published by Batelle Pacific Northwest Laboratories (BNWL-1986). Separate abstracts were prepared for seven of the papers in this proceeding, all going in ERDA Energy Research Abstracts (ERA) and two in Energy Abstracts for Policy Analysis (EAPA). The remaining four have already been cited in ERA and can be found by referring to CONF-761023-- in the report number index. (RWR)

  12. 13th International Symposium on Advanced Materials

    International Nuclear Information System (INIS)

    Qaisar, S.; Khan, A.N.; Mukhtar, E.A.

    2013-01-01

    The 13th international symposium on advanced materials (ISAM) was held from september 23-27, 2013, at islamabad, Pakistan. The main theme of this conference was to discuss the ever increasing changes and intricacies that characterize modern industry necessitate a growing demand for technical information on advanced materials. In five day of the symposium, nearly Two hundred and twenty seven contributory and invited papers, comprising of Nineteen technical sessions and two poster sessions were presented. Renowned scientists and researchers from foreign and local institutes have shared their counter parts on the topics of common interest. This symposium provided an ideal opportunity for exchange of information amongst scientists, engineers and researchers from all over pakistan and other countries of the world. (A.B.)

  13. 28th International Acoustical Imaging Symposium

    CERN Document Server

    André, Michael P; Andre, Michael; Arnold, Walter; Bamber, Jeff; Burov, Valentin; Chubachi, Noriyoshi; Erikson, Kenneth; Ermert, Helmut; Fink, Mathias; Gan, Woon S; Granz, Bernd; Greenleaf, James; Hu, Jiankai; Jones, Joie P; Khuri-Yakub, Pierre; Laugier, Pascal; Lee, Hua; Lees, Sidney; Levin, Vadim M; Maev, Roman; Masotti, Leonardo; Nowicki, Andrzej; O’Brien, William; Prasad, Manika; Rafter, Patrick; Rouseff, Daniel; Thijssen, Johan; Tittmann, Bernard; Tortoli, Piero; Steen, Anton; Waag, Robert; Wells, Peter; Acoustical Imaging

    2007-01-01

    The International Acoustical Imaging Symposium has been held continuously since 1968 as a unique forum for advanced research, promoting the sharing of technology, developments, methods and theory among all areas of acoustics. The interdisciplinary nature of the Symposium and the wide international participation are two of its main strengths. Scientists from around the world present their papers in an informal environment conducive to lively discussion and cross-fertilization. The fact that a loyal community of scientists has supported this Series since 1968 is evidence of its impact on the field. The Symposium Series continues to thrive in a busy calendar of scientific meetings without the infrastructure of a professional society. It does so because those who attend and those who rely on the Proceedings as a well-known reference work acknowledge its value. This Volume 28 of the Proceedings likewise contains an excellent collection of papers presented in six major categories, offering both a broad perspective ...

  14. 30th International Acoustical Imaging Symposium

    CERN Document Server

    Jones, Joie; Lee, Hua

    2011-01-01

    The International Symposium on Acoustical Imaging is a unique forum for advanced research, covering new technologies, developments, methods and theories in all areas of acoustics. This interdisciplinary Symposium has been taking place every two years since 1968. In the course of the years the proceedings volumes in the Acoustical Imaging Series have become a reference for cutting-edge research in the field. In 2009 the 30th International Symposium on Acoustical Imaging was held in Monterey, CA, USA, March 1-4. Offering both a broad perspective on the state-of-the-art as well as  in-depth research contributions by the specialists in the field, this Volume 30 in the Series contains an excellent collection of forty three papers presented in five major categories: Biomedical Imaging Acoustic Microscopy Non-Destructive Evaluation Systems Analysis Signal Analysis and Image Processing Audience Researchers in medical imaging and biomedical instrumentation experts.

  15. Interdisciplinary Symposium on Complex Systems

    CERN Document Server

    Zelinka, Ivan; Rössler, Otto

    2014-01-01

    The book you hold in your hands is the outcome of the "ISCS 2013: Interdisciplinary Symposium on Complex Systems" held at the historical capital of Bohemia as a continuation of our series of symposia in the science of complex systems. Prague, one of the most beautiful European cities, has its own beautiful genius loci. Here, a great number of important discoveries were made and many important scientists spent fruitful and creative years to leave unforgettable traces. The perhaps most significant period was the time of Rudolf II who was a great supporter of the art and the science and attracted a great number of prominent minds to Prague. This trend would continue. Tycho Brahe, Niels Henrik Abel, Johannes Kepler, Bernard Bolzano, August Cauchy Christian Doppler, Ernst Mach, Albert Einstein and many others followed developing fundamental mathematical and physical theories or expanding them. Thus in the beginning of the 17th century, Kepler formulated here the first two of his three laws of planetary motion on ...

  16. Symposium 3 of JENAM 2010

    CERN Document Server

    Recchi, Simone; Hensler, Gerhard; Dwarf Galaxies Keys to Galaxy Formation and Evolution

    2012-01-01

    Dwarf galaxy research constitutes an extremely vibrant field of astrophysical research, with many long-standing questions still unsettled and new ones constantly arising. The intriguing diversity of the dwarf galaxy population, observed with advanced ground-based and space-borne observatories over a wide spectral window providing an unprecedented level of detail, poses new challenges for both observers and theoreticians. The aim of this symposium was to bring together these two groups to exchange ideas and new results on the many evolutionary aspects of and open issues concerning dwarf galaxies. The main topics addressed include: • the birth of dwarf galaxies: theoretical concepts and observable relics across wavelength and time • the morphological, structural and chemical evolution of dwarf galaxies • possible evolutionary connections between early-type and late-type dwarfs • the star formation history of dwarf galaxies and its dependence on intrinsic and environmental properties • the origin ...

  17. Symposium 1 of JENAM 2010

    CERN Document Server

    Molaro, Paolo; From Varying Couplings to Fundamental Physics

    2011-01-01

    Nature is characterized by a number of physical laws and fundamental dimensionless couplings. These determine the  properties of our physical universe, from the size of atoms, cells and mountains to the ultimate fate of the universe as a whole. Yet it is rather remarkable how little we know about them. The constancy of physical laws is one of the cornerstones of the scientific research method, but for fundamental couplings this is an assumption with no other justification  than a historical assumption. There is no 'theory of constants' describing their role in the underlying theories and how they relate to one another or how many  of them are truly fundamental.  Studying the behaviour of these quantities throughout the history of the universe is an effective way to probe fundamental physics. This explains why the ESA and ESO include varying fundamental constants among their key science drivers for the next generation of facilities. This symposium discussed the state-of-the-art in the field, as well as the...

  18. 2. Symposium environmental geotechnics. Papers

    International Nuclear Information System (INIS)

    Klapperich, H.; Katzenbach, R.; Witt, K.J.; Griessl, D.

    2005-01-01

    The 2nd symposium of the chapter section 'Environmental Geotechnics' of DGGT follows the event in Weimar 2003 and focuses on the central topics of Landfill - Contaminated Sites - Brownfields. The stream 'Waste management - Waste Site technology' discusses legal requirements and technical alternatives, especially in view of many upcoming closures of landfill sites and associated surface sealing, as well as technical reports of case studies and developments. The contribution 'Ultimate storage of radioactive waste' illustrates the wider dimensions to geotechnical questions. Between the streams of 'Remediation Techniques' and 'Land Recycling/Land Management' a panel discussion 'From Brownfield Remediation to Land Management' is taking place. The aim is to discuss the way forward and the need to take up the opportunity for future town planning as well as the design of conversion sites and expansive former mining areas. Representatives of authorities involved and project participants have submitted their statements in advance to the following question: 1.) status of remediation - research and practice 2.) what practical significance is attributed to different remediation techniques for the remediation of brownfields? 3.) modern town planning/redevelopment of former mining areas - spatial planning - real estate economy - financing models for redeveloping land - which parameters/instruments work? (orig.)

  19. Symposium 5 of JENAM 2010 /

    CERN Document Server

    Alves, João; Star clusters in the era of large surveys

    2012-01-01

    The symposium “Star Clusters in the Era of Large Surveys” was held in Lisbon on Sep 9-10 during the JENAM 2010. It served as a platform for discussing what and how recent, on-going and planned large-area ground-based and space-based surveys can contribute to producing a major leap in this research field, which has a strong European history. Scientific topics addressed included: • Cluster searches • Clustered vs. isolated star formation, large-scale star formation, enrichment of the field population • Structure, populations and evolution of the Milky Way • Cluster dynamics (internal and within the Milky Way) • Variability of stars in clusters (from time-resolved surveys) • Analysis techniques for large samples • Archiving This proceedings book provides a snapshot of the ongoing discussion on the role of large surveys in star cluster research, and serves as a reference volume for the state-of-the art in the field.

  20. Fourth international radiopharmaceutical dosimetry symposium

    International Nuclear Information System (INIS)

    Schlafke-Stelson, A.T.; Watson, E.E.

    1986-04-01

    The focus of the Fourth International Radiopharmaceutical Dosimetry Symposium was to explore the impact of current developments in nuclear medicine on absorbed dose calculations. This book contains the proceedings of the meeting including the edited discussion that followed the presentations. Topics that were addressed included the dosimetry associated with radiolabeled monoclonal antibodies and blood elements, ultrashort-lived radionuclides, and positron emitters. Some specific areas of discussion were variations in absorbed dose as a result of alterations in the kinetics, the influence of radioactive contaminants on dose, dose in children and in the fetus, available instrumentation and techniques for collecting the kinetic data needed for dose calculation, dosimetry requirements for the review and approval of new radiopharmaceuticals, and a comparison of the effect on the thyroid of internal versus external irradiation. New models for the urinary blader, skeleton including the active marrow, and the blood were presented. Several papers dealt with the validity of traditional ''average-organ'' dose estimates to express the dose from particulate radiation that has a short range in tissue. These problems are particularly important in the use of monoclonal antibodies and agents used to measure intracellular functions. These proceedings have been published to provide a resource volume for anyone interested in the calculation of absorbed radiation dose

  1. International Symposium on Advanced Materials (ISAM 2013)

    Science.gov (United States)

    2014-06-01

    This proceeding is a compilation of peer reviewed papers presented at the 13th International Symposium on Advanced Materials (ISAM 2013) held from September 23-27, 2013, at Islamabad, Pakistan. In my capacity as ISAM-2013 Secretary, I feel honoured that the symposium has ended on a positive note. The ever increasing changes and intricacies that characterize modern industry necessitate a growing demand for technical information on advanced materials. ISAM and other similar forums serve to fulfill this need. The five day deliberations of ISAM 2013, consisted of 19 technical sessions and 2 poster sessions. In all, 277 papers were presented, inclusive of 80 contributory, invited and oral presentations. The symposium also hosted panel discussions led by renowned scientists and eminent researchers from foreign as well as local institutes. The ultimate aim of this proceeding is to record in writing the new findings in the field of advanced materials. I hope that the technical data available in this publication proves valuable to young scientists and researchers working in this area of science. At the same time, I wish to acknowledge Institute of Physics (IOP) Publishing UK, for accepting the research papers from ISAM-2013 for publication in the IOP Conference Series: Materials Science and Engineering. The proceeding will be available on the IOP website as an online open access document. I am profoundly thankful to the Symposium Chairman for his steadfast support and valuable guidance without which ISAM 2013 could not have been the mega event that it turned out to be. My gratitude to all our distinguished participants, session chairs/co-chairs, and reviewers for their active role in the symposium. I appreciate the entire organizing committee for the zest and ardor with which each committee fulfilled its obligations to ISAM. Last yet not the least, my thankfulness goes to all our sponsors for wilfully financing the event. Dr. Sara Qaisar Symposium Secretary Further

  2. 2016 AMS Mario J. Molina Symposium

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Renyi [Texas A & M Univ., College Station, TX (United States)

    2016-11-29

    A named symposium to honor Dr. Mario J. Molina was held 10–14 January 2016, as part of the 96th American Meteorological Society (AMS) Annual Meeting in New Orleans, Louisiana. Dr. Molina first demonstrated that industrially produced chlorofluorocarbons (CFCs) decompose in the stratosphere and release chlorine atoms, leading to catalytic ozone destruction. His research in stratospheric chemistry was instrumental to the establishment of the 1987 United Nations Montreal Protocol to ban ozone-depleting substances worldwide. Dr. Molina’s contributions to preserving the planet Earth not only save the atmospheric ozone layer, but also protect the climate by reducing the emissions of greenhouse gases. He was awarded the 1995 Nobel Prize in Chemistry for his pioneering research in understanding the stratospheric ozone loss mechanism. In 2013, President Barack Obama announced Dr. Molina as a recipient of the Presidential Medal of Freedom. The 2016 AMS Molina Symposium honored Dr. Molina’s distinguished contributions to research related to atmospheric chemistry. The symposium contained an integrated theme related to atmospheric chemistry, climate, and policy. Dr. Molina delivered a keynote speech at the Symposium. The conference included invited keynote speeches and invited and contributed oral and poster sessions, and a banquet was held on Tuesday January 12, 2016. The symposium covered all aspects of atmospheric chemistry, with topics including (1) Stratospheric chemistry, (2) Tropospheric chemistry, (3) Aerosol nucleation, growth, and transformation, (4) Aerosol properties, (5) Megacity air pollution, and (6) Atmospheric chemistry laboratory, field, and modeling studies. This DOE project supported 14 scientists, including graduate students, post docs, junior research scientists, and non-tenured assistant professors to attend this symposium.

  3. Quality assurance and demolition: 2006 symposium

    International Nuclear Information System (INIS)

    Thierfeldt, S.

    2006-01-01

    The '2006 Symposium: Quality Assurance and Demolition' jointly organized by compra GmbH and Brenk Systemplanung GmbH this year again focused on quality assurance and the demolition of nuclear facilities as its main topics. The papers presented ranged from issues of clearance and disposal to demolition technologies and status reports about specific demolition projects. The sixteen presentations at the '2006 Symposium: Quality Assurance and Demolition' offered an interesting and very topical cross section of decommissioning and demolition of nuclear facilities in Germany. In 2007, the conference about similar main topics will again be held at the Schloss Bensberg Grand Hotel. (orig.)

  4. Fifth International Symposium on Magnetic Suspension Technology

    Science.gov (United States)

    Groom, Nelson J. (Editor); Britcher, Colin P.

    2000-01-01

    In order to examine the state of technology of all areas of magnetic suspension and to review recent developments in sensors, controls, superconducting magnet technology, and design/implementation practices, the Fifth International Symposium on Magnetic Suspension Technology was held at the Radisson Hotel Santa Barbara, Santa Barbara, California, on December 1-3, 1999. The symposium included 18 sessions in which a total of 53 papers were presented. The technical sessions covered the areas of bearings, controls, modeling, electromagnetic launch, magnetic suspension in wind tunnels, applications flywheel energy storage, rotating machinery, vibration isolation, and maglev. A list of attendees is included in the document.

  5. Outcome of UNIDO symposium on biomass energy

    International Nuclear Information System (INIS)

    Nazemi, A.H.

    1997-01-01

    The results of the UNIDO symposium are presented. The symposium covered a variety of subjects, beginning with a comparison of biomass energy production and potential uses in different regions, specific country case studies about the present situation and trends in biomass energy utilisation. Technological aspects discussed included the production of biomass resources, their conversion into energy carriers and technology transfer to developing countries. An analysis of financial resources available and mechanisms for funding biomass projects were given. Environmental effects and some relatively successful biomass projects under development were described. (K.A.)

  6. Eleventh symposium on energy engineering sciences: Proceedings

    International Nuclear Information System (INIS)

    1993-01-01

    The Eleventh Symposium on Energy Engineering Sciences was held on May 3--5, 1993, at the Argonne National Laboratory, Argonne, Illinois. These proceedings include the program, list of participants, and the papers that were presented during the eight technical sessions held at this meeting. This symposium was organized into eight technical sessions: Surfaces and interfaces; thermophysical properties and processes; inelastic behavior; nondestructive characterization; multiphase flow and thermal processes; optical and other measurement systems; stochastic processes; and large systems and control. Individual projects were processed separately for the databases

  7. Proceedings of the international symposium NUCEF 2005

    International Nuclear Information System (INIS)

    2005-08-01

    Japan Atomic Energy Research Institute (JAERI) held the international symposium NUCEF 2005 at Techno Community Square RICOTTI in Tokai-mura on February 9 and 10, 2005. This symposium was co-organized by Japan Nuclear Cycle Development Institute (JNC), and Nuclear Fuel Cycle Safety Research Committee authorized the program. Two hundred thirty-nine participants from 11 countries presented fifty-nine papers, and discussed recent research activities and its outputs on waste disposal safety, fuel cycle facility safety including criticality safety, and separation process development. The presented papers are compiled in the proceedings. (author)

  8. Flight Mechanics/Estimation Theory Symposium, 1990

    Science.gov (United States)

    Stengle, Thomas (Editor)

    1990-01-01

    This conference publication includes 32 papers and abstracts presented at the Flight Mechanics/Estimation Theory Symposium on May 22-25, 1990. Sponsored by the Flight Dynamics Division of Goddard Space Flight Center, this symposium features technical papers on a wide range of issues related to orbit-attitude prediction, determination and control; attitude sensor calibration; attitude determination error analysis; attitude dynamics; and orbit decay and maneuver strategy. Government, industry, and the academic community participated in the preparation and presentation of these papers.

  9. Flight Mechanics/Estimation Theory Symposium, 1992

    Science.gov (United States)

    Stengle, Thomas H. (Editor)

    1993-01-01

    This conference publication includes 40 papers and abstracts presented at the Flight Mechanics/Estimation Theory Symposium on May 5-7, 1992. Sponsored by the Flight Dynamics Division of Goddard Space Flight Center, this symposium featured technical papers on a wide range of issues related to orbit-attitude prediction, determination, and control; attitude sensor calibration; attitude determination error analysis; attitude dynamics; and orbit decay and maneuver strategy. Government, industry, and the academic community participated in the preparation and presentation of these papers.

  10. Flight Mechanics/Estimation Theory Symposium 1988

    Science.gov (United States)

    Stengle, Thomas (Editor)

    1988-01-01

    This conference publication includes 28 papers and abstracts presented at the Flight Mechanics/Estimation Theory Symposium on May 10 to 11, 1988. Sponsored by the Flight Dynamics Division of Goddard Space Flight Center, this symposium features technical papers on a wide range of issue related to orbit-attitude prediction, determination and control; attitude sensor calibration; attitude determination error analysis; attitude dynamics; and orbit decay and maneuver strategy. Government, industry, and the academic community participated in the preparation and presentation of these papers.

  11. Flight Mechanics/Estimation Theory Symposium, 1994

    Science.gov (United States)

    Hartman, Kathy R. (Editor)

    1994-01-01

    This conference publication includes 41 papers and abstracts presented at the Flight Mechanics/Estimation Theory Symposium on May 17-19, 1994. Sponsored by the Flight Dynamics Division of Goddard Space Flight Center, this symposium featured technical papers on a wide range of issues related to orbit-attitude prediction, determination and control; attitude sensor calibration; attitude determination error analysis; attitude dynamics; and orbit decay and maneuver strategy. Government, industry, and the academic community participated in the preparation and presentation of these papers.

  12. Transport arrangements for the scientific symposium

    CERN Multimedia

    2000-01-01

    Parking in the region of building 180 will be severely restricted during the LEPFest scientific symposium of 10-11 October, and a special bus service will operate to ferry people to and from the event. From 8:00 am, buses will leave the reception at building 33, stop to pickup passengers outside the hostels (buildings 38 and 39), and drop people off at the symposium venue - building 180. At the end of each day’s proceedings, the buses will bring people back, and through out the day a shuttle service will operate around every 15-20 minutes. Attendees are strongly recommended to use the buses.

  13. International Symposium in honour of Edoardo Vesentini

    CERN Document Server

    1990-01-01

    The volume contains the texts of the main talks delivered at the International Symposium on Complex Geometry and Analysis held in Pisa, May 23-27, 1988. The Symposium was organized on the occasion of the sixtieth birthday of Edoardo Vesentini. The aim of the lectures was to describe the present situation, the recent developments and research trends for several relevant topics in the field. The contributions are by distinguished mathematicians who have actively collaborated with the mathematical school in Pisa over the past thirty years.

  14. Symposium on high temperature and materials chemistry

    International Nuclear Information System (INIS)

    1989-10-01

    This volume contains the written proceedings of the Symposium on High Temperature and Materials Chemistry held in Berkeley, California on October 24--25, 1989. The Symposium was sponsored by the Materials and Chemical Sciences Division of Lawrence Berkeley Laboratory and by the College of Chemistry of the University of California at Berkeley to discuss directions, trends, and accomplishments in the field of high temperature and materials chemistry. Its purpose was to provide a snapshot of high temperature and materials chemistry and, in so doing, to define status and directions

  15. Symposium on high temperature and materials chemistry

    Energy Technology Data Exchange (ETDEWEB)

    1989-10-01

    This volume contains the written proceedings of the Symposium on High Temperature and Materials Chemistry held in Berkeley, California on October 24--25, 1989. The Symposium was sponsored by the Materials and Chemical Sciences Division of Lawrence Berkeley Laboratory and by the College of Chemistry of the University of California at Berkeley to discuss directions, trends, and accomplishments in the field of high temperature and materials chemistry. Its purpose was to provide a snapshot of high temperature and materials chemistry and, in so doing, to define status and directions.

  16. 2. symposium energy crops 2009; 2. Symposium Energiepflanzen 2009

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-27

    Within the meeting '2nd Symposium energy plants 2009', held at 17th to 18th November, 2009, in Berlin (Federal Republic of Germany), the following lectures were held: (1) The bio energy policy of the Federal Government in the area of attention between climatic protection, ecology and economy (Ilse Aigner); (2) Chances and threatens of cultivation of energy plants for a sustainable energy supply (Alois Heissenhuber); (3) Certification as a prerequisite of the global exploration of bio energy (Andreas Feige); (4) A project support in the field of cultivation of energy plants, a review (Andreas Schuette); (5) Results from the investigation of the crop rotation in the EVA network (Armin Vater); (6) Optimisation of the cultivation technology of sorghum millets (Christian Roehricht); (7) The two-culture utilization system - a comparison between ecologic and conventional cultivation (Reinhold Stuelpnagel); (8) Crop rotation with energy plants - Chances and threatens for the plant protection (Baerbel Gerowitt); (9) Efficiency of utilization of water for energy plants (Siegfried Schittenhelm); (10) Utilization of arable food grasses and permanent grassland as a substrate for biogas (Matthias Benke); (11) Economical evaluation of plant fermentation substrates (Dominik Reus); (12) Energy plants as a challenge for the agricultural engineering (Heiner Bruening); (13) Influence of the design of cultivation on the subsequent effects of the cultivation of energy plants (Michael Glemnitz); (14) Energy plants and waters protection - Key aspects and possible options of action (Heike Nitsch); (15) Neophytes as energy plants - Chances and threatens (Werner Kuhn); (16) Manifold in te landscape - extensive cultivation systems with renewable raw materials as an option for nature protection? (Peer Heck); (17) Ecologic aspects of agro forestry systems (Holger Gruenewald); (18) Enhancement of the potential of energy yield of winter wheat (Wolfgang Friedt); (19) Interspersed silphie

  17. Breaking the Cycle of Teenage Pregnancy: Prevention Opportunities Focusing on the Younger Sisters of Teen Mothers.

    Science.gov (United States)

    East, Patricia L.

    1998-01-01

    Describes an under-recognized target population for adolescent pregnancy prevention: the younger sisters of childbearing teens. Data from several studies highlight several potential prepregnancy-risk characteristics that are particularly present in this group. These young women have disproportionately higher rates of early pregnancy and…

  18. Living with a Brother Who Has an Autism Spectrum Disorder: A Sister's Perspective

    Science.gov (United States)

    Connell, Zara O.; Halloran, Maeve O.; Doody, Owen

    2016-01-01

    People with Autism Spectrum Disorder (ASD) are born into families and influence family functioning both positively and negatively. One of the most enduring relationships a person with ASD will have is their relationship with a brother or sister. Services for people with ASD should provide effective support to families, which include brothers,…

  19. Teaching Sisters and Transnational Networks: Recruitment and Education Expansion in the Long Nineteenth Century

    Science.gov (United States)

    Raftery, Deirdre

    2015-01-01

    This article examines the management of the education enterprise of teaching Sisters, with reference to their transnational networking. The article suggests that orders of women religious were the first all-female transnational networks, engaged constantly in work that was characterised by "movement, ebb and circulation". The mobility of…

  20. Food Yields and Nutrient Analyses of the Three Sisters: A Haudenosaunee Cropping System

    Directory of Open Access Journals (Sweden)

    Jane Mt.Pleasant

    2016-11-01

    Full Text Available Scholars have studied The Three Sisters, a traditional cropping system of the Haudenosaunee (Iroquois, from multiple perspectives. However, there is no research examining food yields, defined as the quantities of energy and protein produced per unit land area, from the cropping system within Iroquoia. This article compares food yields and other nutrient contributions from the Three Sisters, comprised of interplanted maize, bean and pumpkin, with monocultures of these same crops. The Three Sisters yields more energy (12.25 x 106 kcal/ha and more protein (349 kg/ha than any of the crop monocultures or mixtures of monocultures planted to the same area. The Three Sisters supplies 13.42 people/ha/yr. with energy and 15.86 people/ha/yr. with protein. Nutrient contents of the crops are further enhanced by nixtamalization, a traditional processing technique where maize is cooked in a high alkaline solution. This process increases calcium, protein quality, and niacin in maize.

  1. New insights on the sister lineage of percomorph fishes with an anchored hybrid enrichment dataset.

    Science.gov (United States)

    Dornburg, Alex; Townsend, Jeffrey P; Brooks, Willa; Spriggs, Elizabeth; Eytan, Ron I; Moore, Jon A; Wainwright, Peter C; Lemmon, Alan; Lemmon, Emily Moriarty; Near, Thomas J

    2017-05-01

    Percomorph fishes represent over 17,100 species, including several model organisms and species of economic importance. Despite continuous advances in the resolution of the percomorph Tree of Life, resolution of the sister lineage to Percomorpha remains inconsistent but restricted to a small number of candidate lineages. Here we use an anchored hybrid enrichment (AHE) dataset of 132 loci with over 99,000 base pairs to identify the sister lineage of percomorph fishes. Initial analyses of this dataset failed to recover a strongly supported sister clade to Percomorpha, however, scrutiny of the AHE dataset revealed a bias towards high GC content at fast-evolving codon partitions (GC bias). By combining several existing approaches aimed at mitigating the impacts of convergence in GC bias, including RY coding and analyses of amino acids, we consistently recovered a strongly supported clade comprised of Holocentridae (squirrelfishes), Berycidae (Alfonsinos), Melamphaidae (bigscale fishes), Cetomimidae (flabby whalefishes), and Rondeletiidae (redmouth whalefishes) as the sister lineage to Percomorpha. Additionally, implementing phylogenetic informativeness (PI) based metrics as a filtration method yielded this same topology, suggesting PI based approaches will preferentially filter these fast-evolving regions and act in a manner consistent with other phylogenetic approaches aimed at mitigating GC bias. Our results provide a new perspective on a key issue for studies investigating the evolutionary history of more than one quarter of all living species of vertebrates. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Error, signal, and the placement of Ctenophora sister to all other animals.

    Science.gov (United States)

    Whelan, Nathan V; Kocot, Kevin M; Moroz, Leonid L; Halanych, Kenneth M

    2015-05-05

    Elucidating relationships among early animal lineages has been difficult, and recent phylogenomic analyses place Ctenophora sister to all other extant animals, contrary to the traditional view of Porifera as the earliest-branching animal lineage. To date, phylogenetic support for either ctenophores or sponges as sister to other animals has been limited and inconsistent among studies. Lack of agreement among phylogenomic analyses using different data and methods obscures how complex traits, such as epithelia, neurons, and muscles evolved. A consensus view of animal evolution will not be accepted until datasets and methods converge on a single hypothesis of early metazoan relationships and putative sources of systematic error (e.g., long-branch attraction, compositional bias, poor model choice) are assessed. Here, we investigate possible causes of systematic error by expanding taxon sampling with eight novel transcriptomes, strictly enforcing orthology inference criteria, and progressively examining potential causes of systematic error while using both maximum-likelihood with robust data partitioning and Bayesian inference with a site-heterogeneous model. We identified ribosomal protein genes as possessing a conflicting signal compared with other genes, which caused some past studies to infer ctenophores and cnidarians as sister. Importantly, biases resulting from elevated compositional heterogeneity or elevated substitution rates are ruled out. Placement of ctenophores as sister to all other animals, and sponge monophyly, are strongly supported under multiple analyses, herein.

  3. Brother-Sister Incest: Data from Anonymous Computer-Assisted Self Interviews

    Science.gov (United States)

    Stroebel, Sandra S.; O'Keefe, Stephen L.; Beard, Keith W.; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-sister incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The…

  4. [The participation of Sister Mathilde de Nina in the historical construction of the Brazilian Nurses Association].

    Science.gov (United States)

    Bezerra, M R

    2001-01-01

    The present work is a study of social-historical nature. It has as its objective understanding the participation of Sister Mathilde Nina, as a representative of the Companhia das Filhas da Caridade (Daughters of Charity Company), in the history of the Brazilian Association of Nursing (ABEn). It discusses the association of this sister to ABEn as a way of spreading the catholic ideology. The study covers a period of time between 1939 and 1950. The primary data was collected through written documents and reports of people who were close to Mathilde Nina. The dialectic method was adopted and the discussion of the findings is based on Pierre Bourdieu's thoughts. As a consequence of the edict 20.109/31, the Sisters of Charity made their insertion in the formal education in Brazil. As the first representative of the Company to graduate, sister Nina could perform in different instances of the nursing profession. Her participation in ABEn was a way of spreading the catholic ideology in nursing.

  5. Constraining volcanic inflation at Three Sisters Volcanic Field in Oregon, USA, through microgravity and deformation modeling

    Science.gov (United States)

    Zurek, Jeffrey; William-Jones, Glyn; Johnson, Dan; Eggers, Al

    2012-10-01

    Microgravity data were collected between 2002 and 2009 at the Three Sisters Volcanic Complex, Oregon, to investigate the causes of an ongoing deformation event west of South Sister volcano. Three different conceptual models have been proposed as the causal mechanism for the deformation event: (1) hydraulic uplift due to continual injection of magma at depth, (2) pressurization of hydrothermal systems and (3) viscoelastic response to an initial pressurization at depth. The gravitational effect of continual magma injection was modeled to be 20 to 33 μGal at the center of the deformation field with volumes based on previous deformation studies. The gravity time series, however, did not detect a mass increase suggesting that a viscoelactic response of the crust is the most likely cause for the deformation from 2002 to 2009. The crust, deeper than 3 km, in the Three Sisters region was modeled as a Maxwell viscoelastic material and the results suggest a dynamic viscosity between 1018 to 5 × 1019 Pa s. This low crustal viscosity suggests that magma emplacement or stall depth is controlled by density and not the brittle ductile transition zone. Furthermore, these crustal properties and the observed geochemical composition gaps at Three Sisters can be best explained by different melt sources and limited magma mixing rather than fractional crystallization. More generally, low intrusion rates, low crustal viscosity, and multiple melt sources could also explain the whole rock compositional gaps observed at other arc volcanoes.

  6. Regulation of sister chromosome cohesion by the replication fork tracking protein SeqA.

    Science.gov (United States)

    Joshi, Mohan C; Magnan, David; Montminy, Timothy P; Lies, Mark; Stepankiw, Nicholas; Bates, David

    2013-01-01

    Analogously to chromosome cohesion in eukaryotes, newly replicated DNA in E. coli is held together by inter-sister linkages before partitioning into daughter nucleoids. In both cases, initial joining is apparently mediated by DNA catenation, in which replication-induced positive supercoils diffuse behind the fork, causing newly replicated duplexes to twist around each other. Type-II topoisomerase-catalyzed sister separation is delayed by the well-characterized cohesin complex in eukaryotes, but cohesion control in E. coli is not currently understood. We report that the abundant fork tracking protein SeqA is a strong positive regulator of cohesion, and is responsible for markedly prolonged cohesion observed at "snap" loci. Epistasis analysis suggests that SeqA stabilizes cohesion by antagonizing Topo IV-mediated sister resolution, and possibly also by a direct bridging mechanism. We show that variable cohesion observed along the E. coli chromosome is caused by differential SeqA binding, with oriC and snap loci binding disproportionally more SeqA. We propose that SeqA binding results in loose inter-duplex junctions that are resistant to Topo IV cleavage. Lastly, reducing cohesion by genetic manipulation of Topo IV or SeqA resulted in dramatically slowed sister locus separation and poor nucleoid partitioning, indicating that cohesion has a prominent role in chromosome segregation.

  7. Polymorphisms in genes encoding the serotonin and dopamine pathways in two sisters with metachromatic leukodystrophy.

    Science.gov (United States)

    Kumperscak, H G; Dolzan, V; Videtic, A; Plesnicar, B K

    2008-01-01

    Metachromatic leukodystrophy (MLD) is a metabolic disease that has recently been investigated as a model for the study of psychosis. We report on two sisters with adult-type MLD who developed psychiatric symptomatology, but differed in their expression of psychotic and depressive symptoms. Association studies have indicated that polymorphisms in genes encoding the serotonin and dopamine transporters and receptors are related to the symptomatology of schizophrenia and/or depression; hence both sisters were genotyped for some of these candidate genes. The sisters shared dopamine receptor D(2) (DRD(2)) c.1047GG (p.311Ser/Ser) and c.-141Cins/ins polymorphisms, which are significantly associated with schizophrenia, but differed in the serotonin transporter gene-linked polymorphic region and serotonin receptor 1A (5-HT(1A)) c.-1019C to G polymorphisms, which may have increased the elder sister's susceptibility to depressive symptoms. Much bigger samples would be needed to gain enough statistical power to develop any hypotheses. This is the first report on genotyping MLD patients for candidate genes for psychiatric disorders, although MLD has been proposed as a model for schizophrenia.

  8. Empirical Psycho-Aesthetics and Her Sisters: Substantive and Methodological Issues--Part II

    Science.gov (United States)

    Konecni, Vladimir J.

    2013-01-01

    Empirical psycho-aesthetics is approached in this two-part article from two directions. Part I, which appeared in the Winter 2012 issue of "JAE," addressed definitional and organizational issues, including the field's origins, its relation to "sister" disciplines (experimental philosophy, cognitive neuroscience of art, and neuroaesthetics), and…

  9. Social Functioning among Girls with Fragile X or Turner Syndrome and Their Sisters.

    Science.gov (United States)

    Mazzocco, Michele M. M.; Baumgardner, Thomas; Freund, Lisa S.; Reiss, Allan L.

    1998-01-01

    Social behaviors among girls (ages 6-16) with fragile X (n=8) or Turner syndrome (n=9) were examined to address the role of family environment versus biological determinants of social dysfunction. Compared to their sisters, subjects had lower IQS and higher rating of social and attention problems. (Author/CR)

  10. Symposium report of Inter-COE international symposium on energy systems

    International Nuclear Information System (INIS)

    2006-10-01

    The symposium of the title aims to discuss a comprehensive possibility of energy system technologies for future society utilizing both specialties of five COEs in energy technology field. The symposium topics include, 'Primary energy production', 'Energy conversion, storage and transportation', 'Energy materials', 'Energy system' by specialists from the COEs. Posters were presented by doctoral course students and others in the COEs, in addition special session 'Energy Research and Human Resources Development'. (J.P.N.)

  11. Second national symposium `Thermal solar energy`; Zweites nationales Symposium Thermische Solarenergie

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    The symposium on thermal solar energy utilization focussed on embracing aspects of thermal solar energy, standardization, testing, quality assurance, and the use of passive solar energy. Each of the 23 papers given at the meeting was abstracted for separate entry into the data base. (BWI). [Deutsch] Im Mittelpunkt des Symposiums zur thermischen Solarenergienutzung stehen uebergreifende Aspekte der thermischen Solarenergie, Normung, Test und Qualitaetssicherung sowie die Nutzung der passiven Solarenergie. Fuer alle 23 enthaltenen Fachbeitraege wurde eine gesonderte inhaltliche Erschliessung durchgefuehrt. (BWI).

  12. Extensive range overlap between heliconiine sister species: evidence for sympatric speciation in butterflies?

    Science.gov (United States)

    Rosser, Neil; Kozak, Krzysztof M; Phillimore, Albert B; Mallet, James

    2015-06-30

    Sympatric speciation is today generally viewed as plausible, and some well-supported examples exist, but its relative contribution to biodiversity remains to be established. We here quantify geographic overlap of sister species of heliconiine butterflies, and use age-range correlations and spatial simulations of the geography of speciation to infer the frequency of sympatric speciation. We also test whether shifts in mimetic wing colour pattern, host plant use and climate niche play a role in speciation, and whether such shifts are associated with sympatry. Approximately a third of all heliconiine sister species pairs exhibit near complete range overlap, and analyses of the observed patterns of range overlap suggest that sympatric speciation contributes 32%-95% of speciation events. Müllerian mimicry colour patterns and host plant choice are highly labile traits that seem to be associated with speciation, but we find no association between shifts in these traits and range overlap. In contrast, climatic niches of sister species are more conserved. Unlike birds and mammals, sister species of heliconiines are often sympatric and our inferences using the most recent comparative methods suggest that sympatric speciation is common. However, if sister species spread rapidly into sympatry (e.g. due to their similar climatic niches), then assumptions underlying our methods would be violated. Furthermore, although we find some evidence for the role of ecology in speciation, ecological shifts did not show the associations with range overlap expected under sympatric speciation. We delimit species of heliconiines in three different ways, based on "strict and " "relaxed" biological species concepts (BSC), as well as on a surrogate for the widely-used "diagnostic" version of the phylogenetic species concept (PSC). We show that one reason why more sympatric speciation is inferred in heliconiines than in birds may be due to a different culture of species delimitation in the two

  13. Symposium on John Dewey's "Art as Experience."

    Science.gov (United States)

    Burnett, Joe R.; And Others

    1989-01-01

    Reports on a symposium about John Dewey's philosophy of art. John Fisher, Richard Shusterman, and Joe R. Burnett state their views on Dewey's contributions to art theory and aesthetics citing Dewey's work, "Art As Experience." The consensus was that although Dewey's opinions are dated, his pragmatist's views offer the opportunity for…

  14. 7th International Symposium on Gaseous Dielectrics

    CERN Document Server

    James, David

    1994-01-01

    The Seventh International Symposium on Gaseous Dielectrics was held in Knoxville, Tennessee, U. S. A. , on April 24-28, 1994. The symposium continued the interdisciplinary character and comprehensive approach of the preceding six symposia. Gaseous DielecIries VII is a detailed record of the symposium proceedings. It covers recent advances and developments in a wide range of basic, applied and industrial areas of gaseous dielectrics. It is hoped that Gaseous DielecIries VII will aid future research and development in, and encourage wider industrial use of, gaseous dielectrics. The Organizing Committee of the Seventh International Symposium on Gaseous Dielectrics consisted of G. Addis (U. S. A. ), L. G. Christophorou (U. S. A. ), F. Y. Chu (Canada), A. H. Cookson (U. S. A. ), O. Farish (U. K. ), I. Gallimberti (Italy) , A. Garscadden (U. S. A. ), D. R. James (U. S. A. ), E. Marode (France), T. Nitta (Japan), W. Pfeiffer (Germany), Y. Qiu (China), I. Sauers (U. S. A. ), R. J. Van Brunt (U. S. A. ), and W. Zaengl...

  15. SNEAP 78: symposium of Northeastern accelerator personnel

    Energy Technology Data Exchange (ETDEWEB)

    Bair, J.K.; Jones, C.M. (comps.)

    1979-06-01

    Session topics of the symposium include: tubes, vacuum, and conditioning; gaseous insulation and gas handling systems; charging systems; safety; ion sources; projects recently completed or under construction; stripping; beam transport; control systems; and telemetry. Twenty eight items were included separately in the data base. (GHT)

  16. Symposium: A Beginning in the Humanities

    Science.gov (United States)

    Brooks, Peter; Fry, Paul H.; Carnochan, W. B.; Culler, Jonathan; Lerer, Seth; Marshall, Donald G.; Johnson, Barbara; Steiner, Wendy; Haack, Susan; Nussbaum, Martha C.

    2002-01-01

    2001 marked Yale's 300th birthday. It seemed an opportunity for reflection on the evolution of the institution, and particularly on the vicissitudes of the humanities over those three centuries. This article presents essays which represent a selection from the symposium, "Beginning With the Humanities," held at the Whitney Humanities Center on…

  17. The ninth international veterinary immunology symposium

    Science.gov (United States)

    This Introduction to the special issue of Veterinary Immunology and Immunopathology summarizes the Proceedings of the 9th International Veterinary Immunology Symposium (9th IVIS) held August, 2010, in Tokyo, Japan. Over 340 delegates from 30 countries discussed research progress analyzing the immune...

  18. The 42nd Aerospace Mechanism Symposium

    Science.gov (United States)

    Boesiger, Edward A. (Editor); Hakun, Claef (Editor)

    2014-01-01

    The Aerospace Mechanisms Symposium (AMS) provides a unique forum for those active in the design, production, and use of aerospace mechanisms. A major focus is the reporting of problems and solutions associated with the development, and flight certification of new mechanisms.

  19. Proceedings of the International Symposium on Biotechnology

    International Nuclear Information System (INIS)

    2008-01-01

    This is a book of abstracts of oral communications and posters that were presented during the International Symposium on Biotechnology that was held in Sfax, Tunisia from May 4th to 8th, 2008. The following themes were covered : - Biotechnology for animal and human health and biopharmaceuticals; - Microbial and environmental biotechnology; - Agricultural, Food and marine biotechnology

  20. 10. International Symposium on Nuclear Electronics

    International Nuclear Information System (INIS)

    Flaemig, E.; Koenig, K.H.

    1980-03-01

    The report contains the abstracts to the main topics of the symposium arranged in 4 chapters. Section A: electronics instrumentation for accelerators and reactors. Section B: amplitude and time spectroscopy. Section C: measuring electronics in high energy physics. Section D: application of computer aided systems in experiments with special regard to microcomputers and the CAMAC system

  1. 6th International Immunoglobulin Symposium: poster presentations

    NARCIS (Netherlands)

    Fernandez-Cruz, E.; Kaveri, S. V.; Peter, H.-H.; Durandy, A.; Cantoni, N.; Quinti, I.; Sorensen, R.; Bussel, J. B.; Danieli, M. G.; Winkelmann, A.; Bayry, J.; Käsermann, F.; Späth, P.; Helbert, M.; Salama, A.; van Schaik, I. N.; Yuki, N.

    2009-01-01

    The posters presented at the 6th International Immunoglobulin Symposium covered a wide range of fields and included both basic science and clinical research. From the abstracts accepted for poster presentation, 12 abstracts were selected for oral presentations in three parallel sessions on

  2. 6th International Immunoglobulin Symposium: Poster presentations

    NARCIS (Netherlands)

    Fernandez-Cruz, E.; Kaveri, S.V.; Peter, H.H.; Durandy, A.; Cantoni, N.; Quinti, I.; Sorensen, R.; Bussel, J.B.; Danieli, M.G.; Winkelmann, A.; Bayry, J.; Kaesermann, F.; Spaeth, P.; Helbert, M.; Salama, A.; van Schaik, I.N.; Yuki, N.

    2009-01-01

    P>The posters presented at the 6th International Immunoglobulin Symposium covered a wide range of fields and included both basic science and clinical research. From the abstracts accepted for poster presentation, 12 abstracts were selected for oral presentations in three parallel sessions on

  3. Intergas `95: International unconventional gas symposium. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    The International Unconventional Gas Symposium was held on May 14--20, 1995 in Tuscaloosa, Alabama where 52 reports were presented. These reports are grouped in this proceedings under: geology and resources; mine degasification and safety; international developments; reservoir characterization/coal science; and environmental/legal and regulatory. Each report has been processed separately for inclusion in the Energy Science and Technology Database.

  4. Abstracts: 2nd interventional MRI symposium

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1997-09-01

    Main topics of the 2nd interventional MRI symposium were: MR compatibility and pulse sequences; MR thermometry, biopsy, musculoskeletal system; laser-induced interstitial thermotherapy, radiofrequency ablations; intraoperative MR; vascular applications, breast, endoscopy; focused ultrasound, cryotherapy, perspectives; poster session with 34 posters described. (AJ)

  5. Abstracts: 2nd interventional MRI symposium

    International Nuclear Information System (INIS)

    Anon.

    1997-01-01

    Main topics of the 2nd interventional MRI symposium were: MR compatibility and pulse sequences; MR thermometry, biopsy, musculoskeletal system; laser-induced interstitial thermotherapy, radiofrequency ablations; intraoperative MR; vascular applications, breast, endoscopy; focused ultrasound, cryotherapy, perspectives; poster session with 34 posters described. (AJ)

  6. Artiss Symposium 2014: Psychiatry and Pain Management

    Science.gov (United States)

    2014-01-01

    compulsion ? Are some patients repeating the past? Is this their way of repeating or projecting their transference upon their provider? What about the...for each pill; up to $80 for one pill. Abusers quickly run out of pills, and an easy alternative is to buy a bag 38 Artiss Symposium 2014

  7. Income Tax Reform and Agriculture: A Symposium.

    Science.gov (United States)

    Economic Research Service (USDA), Washington, DC.

    Five papers are provided from a symposium organized to present several economic studies relating to income tax structure and reform in agriculture. "Toward an Optimal Income Tax Policy for Southern and U.S. Agriculture" (Harold F. Breimyer) is a structured argument for comprehensive tax reform that increases the equity of the income tax…

  8. Fourth Global Health Systems Research Symposium features ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2017-01-13

    Jan 13, 2017 ... Dr Lokossou and two other IMCHA researchers, Dr Emmanuel Ochola of St Mary's Lacor Hospital, Uganda, and Dr Ermel Johnson of the West Africa Health Organization, were selected in the cohort of “HSG Speaks”. They provided live coverage of symposium activities by capturing and highlighting key ...

  9. International Symposium on Karst Water Resources

    Science.gov (United States)

    Back, William

    The International Association of Hydrological Sciences (IAHS) and the International Association of Hydrogeologists (IAH) joined the Hacettepe University of Ankara, Turkey, in sponsoring the International Symposium on Karst Water Resources. The other sponsors of the symposium were the Karst Water Resources Research Center Project of Hacettepe University and the United Nations Development Program through the United Nations Department of Technical Cooperation for Development, in addition to the following government organizations of Turkey: Ministry of Energy and Natural Resources, State Hydraulic, Works (DSI), General Directorate of Mineral Research and Exploration (MTA), Electrical Power Resources Survey and Development Administration (EIE) and Geological Engineering Department of the Engineering Faculty and Karst Hydrogeology Research Group (KRG) at the Hacettepe University Earth Sciences Application and Research Center. Cooperating organizations included the Turkish National Committee of the International Hydrological Program, the United Nations Educational, Scientific, and Cultural Organization (UNESCO), and the International Water Resources Association (IWRA). The symposium was divided into two parts: a paper presentation session held at the new Turkish National Library in Ankara during July 7-12, 1985, and a field trip from Ankara through Konya and Antalya to Izmir during July 13-18. The symposium chairman was Gultekin Gunay of the Hydrogeological Engineering Department of Ankara's Hacettepe University, and the cochairman was A. Ivan Johnson, a water resources consultant from Denver, Colo., and editor of WaterWatch. Scientists from 27 countries were represented among the 200 or so participants in attendance.

  10. SIAM symposium on control problems in industry

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    This symposium focused on industrial control applications that have benefited from recent mathematical and technological developments. The themes featured included: applications of control techniques in aerospace industry, automotive industry, environmental sciences, manufacturing processes, and petroleum industry; optimal shape design in aerospace applications; optimal design of micro-optics; robust control and H-infinity methods.

  11. MEMORIAL SYMPOSIUM:
    Willi Jentschke

    CERN Multimedia

    CERN. Geneva

    2002-01-01

    - Welcome by L. Maiani - Message from DESY by E. Lohrmann - Willi Jentschke by H. Schopper - The Neutral Currents by M. Veltman and D. Perkins - The ISR in Jentschke's time by K. Johnsen - Some recollections of Jentschke by K. WinterNote: Participants are cordially invited to drinks at 17h.30 following the symposium

  12. The seventh international symposium on radiopharmacology

    International Nuclear Information System (INIS)

    1991-01-01

    Abstracts are presented from the symposium on radiopharmacology. Sessions included: pharmokinetics of Tc-99m labeled agents; pharmokinetics and tumor imaging; miscellaneous pharmokinetic studies; pharmokinetics of brain/receptor imaging; pharmokinetics of radiolabeled antibodies; pharmokinetics of radiolabeled lipids; pharmokinetics of heart/infection imaging. Individual reports are processed separately for the databases

  13. The Second International Symposium on Plant Cryopreservation

    Science.gov (United States)

    The Second International Symposium on Plant Cryopreservation was held in Fort Collins, Colorado, USA, from August 11-14, 2013, under the auspices of the International Society for Horticultural Science. The town of Fort Collins is home to the USDA-ARS, National Center for Genetic Resources Preservati...

  14. 16. International oil field chemistry symposium

    International Nuclear Information System (INIS)

    2006-03-01

    The symposium deals with topics on well chemicals, petrochemicals, well injection fluids, reservoir describing methods, reservoir exploitation enhancing chemicals, corrosion inhibitors, production methods and chemical aspects of maintenance, multiphase flow and reservoir geochemistry. The environmental effects of the chemicals and preservation of the environment is also focussed on. Some aspects of decommissioning of oil fields are dealt with

  15. Emotional Intelligence, Identity Salience, and Metaphors. Symposium.

    Science.gov (United States)

    2002

    This document contains three papers from a symposium on emotional intelligence, identity salience, and metaphors in human resource development (HRD). "Applying Client and Consultant Generated Metaphors in HRD: Lessons from Psychotherapy" (Darren Short) reviews some techniques that psychotherapists have devised for using their own…

  16. Second invitational well-testing symposium proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-01

    The symposium dealt with the state of the art of injection of fluids underground, and its application to geothermal systems in particular. Separate abstracts were prepared for fourteen papers and three abstracts of papers were listed by title. Three papers were previously abstracted for EDB.

  17. First symposium accelerated partial breast irradiation

    International Nuclear Information System (INIS)

    2012-01-01

    The First symposium accelerated partial breast irradiation, was organized by the Marie Curie Foundation, between the 14 to 16 june 2012, in the Cordoba city of Argentina. In this event were presented some papers on the following topics: radiotherapy in breast cancer; interaction between systemic treatments and radiotherapy; interstitial brachytherapy.

  18. 12th International Symposium Continuous Surface Mining

    CERN Document Server

    2015-01-01

    This edited volume contains research results presented at the 12th International Symposium Continuous Surface Mining, ISCSM Aachen 2014. The target audience primarily comprises researchers in the lignite mining industry and practitioners in this field but the book may also be beneficial for graduate students.

  19. PREFACE: Third International Symposium on Atomic Technology

    Science.gov (United States)

    Yasumori, Atsuo

    2009-09-01

    The International Symposium on Atomic Technology (ISAT) is held every year. The Third Symposium (ISAT-3) was held on 5-6 March 2009 at the Tokyo International Exchange Center, Tokyo, Japan jointed with the Third Polyscale Technology Workshop (PTW-3). The ISAT-3 symposium was intended to offer a forum for the discussion of the latest progress in atomic technologies, which was successively held after ISAT-1 at Tsukuba and ISAT-2 at Awaji in 2007. The symposium was attended by 136 participants. There were 12 invited and 4 oral presentations. The number of poster presentations was 101. From all the contributions, 32 papers selected through review process are contained in this volume. The 'Atomic Technology Project' and the 'Polyscale Technology Project' were started in 2006 as the joint project of three institutions; (1) Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University (CAMT), (2) Tsukuba Research Center for Interdisciplinary Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba (TIMS) and (3) Polyscale Technology Research Center, Research Institute for Science and Technology, Tokyo University of Science (PTRC), each of which were independently pursuing atomic and polyscale technologies. The project is funded by the Ministry of Education, Culture, Sports, Science and Technology of Japan. The goal of these projects is to contribute to the development of atomic and polyscale science and technologies. In this symposium, four research fields were focused on: Biomedical Applications, Fabrication for Advanced Materials and Devices, Magnetic Applications, and Quantum and Molecular Engineering for Advanced Technologies. Atsuo Yasumori Conference Chair Polyscale Technology Research Center, Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.

  20. HIV Reservoir Characterization Symposium: 19 September 2016, Ghent, Belgium.

    Science.gov (United States)

    Malatinkova, Eva; De Spiegelaere, Ward; Vandekerckhove, Linos; Sips, Magdalena

    2017-01-01

    The HIV Cure Research Center (HCRC) in Ghent organised the first HIV Reservoir Characterization Symposium, and brought together virologists, molecular biologists, immunologists and clinicians to discuss the most recent developments in HIV reservoir characterisation with a view to achieving an HIV cure. The one-day symposium covered new developments in the field of HIV reservoir and HIV cure research, with the latest news on the European HIV cure trials. This report summarises the major themes discussed during the symposium.

  1. Proceedings of the international nuclear power plant aging symposium

    International Nuclear Information System (INIS)

    Beranek, A.

    1989-03-01

    This report presents the proceedings of the International Nuclear Power Plant Aging Symposium that was held at the Hyatt Regency Hotel in Bethesda, Maryland, on August 30-31 and September 1, 1988. The Symposium was presented in cooperation with the American Nuclear Society, the American Society of Civil Engineers, the American Society of Mechanical Engineers, and the Institute of Electrical and Electronics Engineers. There were approximately 550 participants from 16 countries at the Symposium

  2. Proceedings of the First International Symposium on Robust Design 2014

    DEFF Research Database (Denmark)

    The symposium concerns the topic of robust design from a practical and industry orientated perspective. During the 2 day symposium we will share our understanding of the need of industry with respect to the control of variance, reliability issues and approaches to robust design. The target audience...... for the symposium therefore will aim to attract equal numbers of industry and academic delegates with two separate paper submission tracks....

  3. 3rd International Symposium on Innovative Management, Information and Production

    CERN Document Server

    Xu, Bing; Wu, Berlin

    2014-01-01

    Innovative Management in Information and Production is based on the proceedings of the Third International Symposium on Innovative Managemet, Information and Production. This symposium is held by International Society of Management Engineers. The symposium took place on October 8-10, in Ho Chi Minh City, Vietnam. This book examines recent innovative management of information and productions such as digital collection management and operations planning, scheduling and control.

  4. 1st Jagiellonian Symposium on Fundamental and Applied Subatomic Physics

    CERN Document Server

    2016-01-01

    Following the success of two meetings "II Symposium on applied nuclear physics and innovative technologies" and "II Symposium on Positron Emission Tomography" organized in 2014, this event will start a new series of conferences which will bring together scientists from the physics, nuclear medicine and healthcare. One of the main purposes of the symposium is to exchange experience and and expertise gained by various institutions in the field of applied and fundamental nuclear as well as particle physics, medical imaging, radiotherapy and healthcare.

  5. Proceedings of the Twelfth International Symposium on Space Terahertz Technology

    Science.gov (United States)

    Mehdi, Imran (Editor)

    2001-01-01

    The Twelfth International Symposium on Space Terahertz Technology was held February 14-16, 2001 in San Diego, California, USA. This symposium was jointly sponsored by the National Aeronautics and Space Administration (NASA) and the Jet Propulsion Laboratory, California Institute of Technology. The symposium featured sixty nine presentations covering a wide variety of technical topics relevant to Terahertz Technology. The presentations can be divided into five broad technology areas: Hot Electron Bolometers, superconductor insulator superconductor (SIS) technology, local oscillator (LO) technology, Antennas and Measurements, and Direct Detectors. The symposium provides scientists, engineers, and researchers working in the terahertz technology and science fields to engineers their work and exchange ideas with colleagues.

  6. Proceedings of the seventh symposium on laser spectroscopy

    International Nuclear Information System (INIS)

    1999-01-01

    This proceedings contains articles of the 7th symposium on laser spectroscopy and this symposium is held on Nov. 5-6, 1999 by KAERI. Both the laser and laser beams are critically used in many most precise measurements in science and technology. We discussed about the recently developed subjects in detail during the this symposium. This proceedings is composed of two major parts. One is the invitational lectures and the other is the research papers. And we have a number of invited speakers from several advanced countries. Their talks are the highlights of this symposium. (Cho, G. S.)

  7. The first record of a trans-oceanic sister-group relationship between obligate vertebrate troglobites.

    Directory of Open Access Journals (Sweden)

    Prosanta Chakrabarty

    Full Text Available We show using the most complete phylogeny of one of the most species-rich orders of vertebrates (Gobiiformes, and calibrations from the rich fossil record of teleost fishes, that the genus Typhleotris, endemic to subterranean karst habitats in southwestern Madagascar, is the sister group to Milyeringa, endemic to similar subterranean systems in northwestern Australia. Both groups are eyeless, and our phylogenetic and biogeographic results show that these obligate cave fishes now found on opposite ends of the Indian Ocean (separated by nearly 7,000 km are each others closest relatives and owe their origins to the break up of the southern supercontinent, Gondwana, at the end of the Cretaceous period. Trans-oceanic sister-group relationships are otherwise unknown between blind, cave-adapted vertebrates and our results provide an extraordinary case of Gondwanan vicariance.

  8. Umbilical metastasis (Sister Mary Joseph's nodule diagnosed by fine-needle aspiration

    Directory of Open Access Journals (Sweden)

    Tatomirović Željka

    2004-01-01

    Full Text Available Sister Mary Joseph’s nodule is the eponym for metastatic involvement of the umbilicus. This less common entity is the sign of disseminated malignant disease, mainly of digestive and gynecologic origin, and is associated with a poor prognosis. A case of Sister Mary Joseph’s nodule in a 76-year-old woman in whom the umbilical metastasis was the first sign of malignant disease in presented. The diagnosis of metastatic adenocarcinoma was established by fine needle aspiration cytology of the umbilical nodule. Radiological and ultrasonographic investigation disclosed carcinoma of the gallbladder with pancreas, stomach, and colon invasion as well as peritoneal dissemination. The diagnosis was confirmed by exploratory laparatomy and histological examination of the excised umbilical nodule.

  9. Friel and his "sisters"DOI:10.5007/2175-8026.2010n58p99

    Directory of Open Access Journals (Sweden)

    Nicholas Grene

    2010-01-01

    Full Text Available This essay, occasioned by a revival of Brian Friel's version of Chekhov's Three Sisters at the Abbey Theatre in 2008, considers the circumstances surrounding its first production by the Field Day Theatre Company in 1981, and the motivation behind the decision to translate Chekhov's text into a specifically Irish dialect of English. It also analyses how Friel's plays since that date, notably the award-winning Dancing at Lughnasa (1990, have changed our perspective on the play.

  10. Maria Carolina and Marie Antoinette: Sisters and Queens in the mirror of Jacobin Public Opinion

    Directory of Open Access Journals (Sweden)

    Cinzia Recca

    2014-09-01

    Full Text Available Marie Antoinette of Franceand Maria Carolina of Naples, both consorts, contributed to a flourishing of matronage, reproducing conceptions of royal femininity that embraced both the private and public roles they were expected to fulfil. However, while the political role of the first Queen has been largely reconsidered, her sister Maria Carolina has not yet been adjudicated impartially. This is somewhat curious, because Maria Carolina inherited from her sister the same disregard towards the Revolution and this, as perceived by the Jacobins, was duly proposed in their acrimonious criticism of her political role. This paper aims to focus on this criticism, analysing how the charges against Maria Carolina in the post-French revolutionary period, were a political duplication of the Jacobin attacks on Marie Antoinette from 1791 onwards. From this point of view, the paper will focus on the portrait of Maria Carolina in 1793 revolutionary Parisby Giuseppe Gorani, an Italian Jacobin noble. His Mémoires Secrets – where Maria Carolina was represented as a wicked woman in the same terms previously employed to denounce her sister Marie Antoinette by the French Republicans – was well known across Italy. This subject dominated the main pamphlets and brochures published in Naples in 1799, during the brief duration of the Neapolitan Republic, because it legitimised the rebellion against the monarchy. After the fall of the Neapolitan Republic, the political attacks on Maria Carolina continued likewise in France, where many Neapolitan patriots were obliged to flee. Analysing  Giuseppe Gorani’s Mémoires we gather that the portrait of Marie Antoinette’s sister was painted according to the main stereotypes of  French revolutionary political culture.

  11. On Brothers and Sisters: South Asian and Japanese Idea Systems and their Consequences

    OpenAIRE

    Lyon, Stephen M.

    2017-01-01

    The role expectations of cross siblings varies across culture. Such expectations, while not rigidly prescribing actual behaviors nevertheless influences relations between brothers and sisters in observable ways. In South Asia, a cultural rhetoric of sororal sacrifice and support coupled with fraternal protection are commonplace. While such noble sibling roles are regularly transgressed they remain powerful idioms of the relationship and transgressions require appropriate cultural justificatio...

  12. Secret Sisters: Women Religious under European Communism Collection at the Catholic Theological Union

    Directory of Open Access Journals (Sweden)

    Vincent P. Tinerella

    2010-10-01

    Full Text Available After the fall of Communism in Eastern Europe, Pope John Paul II asked Catholics around the world to assist members of the Church who had suffered under the yoke of communist oppression as a result of their commitment to Catholicism. Sr. Margaret Savoie, and Sr. Margaret Nacke, Sisters of St. Joseph, Concordia, Kansas, decided that the experiences of Catholic women in religious communities – “surviving sisters” – was an important story that needed to be documented, preserved, and made available for future generations and researchers. In 2003, Sisters Mary and Margaret began their research, recording the plight of Catholic sisters in eight countries, Bulgaria, Czech Republic, Hungary, Lithuania, Romania, Slovakia, and the Ukraine, from the rise of Stalin until the collapse of European communism. Over 200 testimonials now reside at the Paul Bechtold Library at the Catholic Theological Union in Chicago under the auspices of the library’s archivist, Dr. Kenneth O’Malley, C.P. , and their work has been made into a national and award-winning documentary film. .

  13. Tenth international symposium on environmental biogeochemistry

    Energy Technology Data Exchange (ETDEWEB)

    Ehrlich, H.L.

    1992-01-01

    The primary task of this Symposium on Environmental Biogeochemistry was to examine our current understanding of GLOBAL CHANGE AND THE BIOGEOCHEMISTRY OF RADIATIVE TRACE GASES. The symposium was divided into 12 non-overlapping sessions: Paleoatmospheres and paleoclimates; Global distributions and atmospheric reactions; Poster presentations on the topics of sessions 1, 2, 4, 5, and 7; Terrestrial systems and land use change - 1; Terrestrial and land use change - 11; Fluxes and cycling in aquatic systems; Metals, organics, and depositional environments; Poster presentations on the topics of sessions 6, 9, 10 and 12; Biological Mechanisms of formation and destruction - 1; Biological mechanisms of formation and destruction - 11; High latitude systems; and Global sources, sinks, and feedbacks.

  14. 29th International Symposium on Shock Waves

    CERN Document Server

    Ranjan, Devesh

    2015-01-01

    This proceedings present the results of the 29th International Symposium on Shock Waves (ISSW29) which was held in Madison, Wisconsin, U.S.A., from July 14 to July 19, 2013. It was organized by the Wisconsin Shock Tube Laboratory, which is part of the College of Engineering of the University of Wisconsin-Madison. The ISSW29 focused on the following areas: Blast Waves, Chemically Reactive Flows, Detonation and Combustion,  Facilities, Flow Visualization, Hypersonic Flow, Ignition, Impact and Compaction, Industrial Applications, Magnetohydrodynamics, Medical and Biological Applications, Nozzle Flow, Numerical Methods, Plasmas, Propulsion, Richtmyer-Meshkov Instability, Shock-Boundary Layer Interaction, Shock Propagation and Reflection, Shock Vortex Interaction, Shock Waves in Condensed Matter, Shock Waves in Multiphase Flow, as well as Shock Waves in Rarefield Flow. The two Volumes contain the papers presented at the symposium and serve as a reference for the participants of the ISSW 29 and individuals interes...

  15. 30th International Symposium on Shock Waves

    CERN Document Server

    Sadot, Oren; Igra, Ozer

    2017-01-01

    These proceedings collect the papers presented at the 30th International Symposium on Shock Waves (ISSW30), which was held in Tel-Aviv Israel from July 19 to July 24, 2015. The Symposium was organized by Ortra Ltd. The ISSW30 focused on the state of knowledge of the following areas: Nozzle Flow, Supersonic and Hypersonic Flows with Shocks, Supersonic Jets, Chemical Kinetics, Chemical Reacting Flows, Detonation, Combustion, Ignition, Shock Wave Reflection and Interaction, Shock Wave Interaction with Obstacles, Shock Wave Interaction with Porous Media, Shock Wave Interaction with Granular Media, Shock Wave Interaction with Dusty Media, Plasma, Magnetohyrdrodynamics, Re-entry to Earth Atmosphere, Shock Waves in Rarefied Gases, Shock Waves in Condensed Matter (Solids and Liquids), Shock Waves in Dense Gases, Shock Wave Focusing, Richtmyer-Meshkov Instability, Shock Boundary Layer Interaction, Multiphase Flow, Blast Waves, Facilities, Flow Visualization, and Numerical Methods. The two volumes serve as a reference ...

  16. 4th international interdisciplinary chaos symposium

    CERN Document Server

    Banerjee, Santo; Caglar, Suleyman; Ozer, Mehmet; Chaos and complex systems

    2013-01-01

    Complexity Science and Chaos Theory are fascinating areas of scientific research with wide-ranging applications.  The interdisciplinary nature and ubiquity of complexity and chaos are features that provides scientists with a motivation to pursue general theoretical tools and frameworks. Complex systems give rise to emergent behaviors, which in turn produce novel and interesting phenomena in science, engineering, as well as in the socio-economic sciences. The aim of all Symposia on Chaos and Complex Systems (CCS) is to bring together scientists, engineers, economists and social scientists, and to discuss the latest insights and results obtained in the area of corresponding nonlinear-system complex (chaotic) behavior. Especially for the “4th International Interdisciplinary Chaos Symposium on Chaos and Complex Systems,” which took place April 29th to May 2nd, 2012 in Antalya, Turkey, the scope of the symposium had been further enlarged so as to encompass the presentation of work from circuits to econophysic...

  17. Special Issue International CAWSES-II Symposium

    Science.gov (United States)

    Yamamoto, Mamoru; Shiokawa, Kazuo; Nakamura, Takuji; Gopalswamy, Nat

    2016-01-01

    This special issue gathered papers from the International CAWSES-II Symposium (November 18-22, 2013 at Nagoya University, Japan). Climate and Weather of the Sun-Earth System II (CAWSES-II) is an international scientific program sponsored by Scientific Committee on Solar-Terrestrial Physics (SCOSTEP) that continued from 2009 to 2013. The program was established with the aim of significantly enhancing our understanding of the space environment and its impacts on life and society. The International CAWSES-II Symposium was successful with 388 presentations; and from that, 38 papers were published in this special issue. In this preface, we briefly discuss the contents of the special issue as well as the CAWSES-II review papers published in Progress in Earth and Planetary Science (PEPS) in 2014-2015.

  18. 2016 International Symposium on Experimental Robotics

    CERN Document Server

    Nakamura, Yoshihiko; Khatib, Oussama; Venture, Gentiane

    2017-01-01

    Experimental Robotics XV is the collection of papers presented at the International Symposium on Experimental Robotics, Roppongi, Tokyo, Japan on October 3-6, 2016. 73 scientific papers were selected and presented after peer review. The papers span a broad range of sub-fields in robotics including aerial robots, mobile robots, actuation, grasping, manipulation, planning and control and human-robot interaction, but shared cutting-edge approaches and paradigms to experimental robotics. The readers will find a breadth of new directions of experimental robotics. The International Symposium on Experimental Robotics is a series of bi-annual symposia sponsored by the International Foundation of Robotics Research, whose goal is to provide a forum dedicated to experimental robotics research. Robotics has been widening its scientific scope, deepening its methodologies and expanding its applications. However, the significance of experiments remains and will remain at the center of the discipline. The ISER gatherings are...

  19. Quality assurance and demolition: 2008 symposium

    International Nuclear Information System (INIS)

    Schartmann, F.; Thierfeldt, S.

    2008-01-01

    The 'Quality Assurance and Demolition Symposium, which has become a tradition established jointly by Applus RTD Deutschland GmbH (formerly compra GmbH) and Brenk Systemplanung GmbH, Aachen, was held also in 2008 with the focus on quality assurance and the demolition of nuclear facilities. The conference began with a series of lectures on knowledge and document management in general, and the use of document management systems in the nuclear field in particular. The evening lecture was presented by Axel Weis (Karlsruhe Research Center) on 'Competence Preservation in Nuclear Technology'. The 24 technical papers presented on the next 2 days of the symposium dealt with non-destructive materials testing and with special problems of radiation protection, demolition, and waste management. In 2009, the meeting will cover similar main topics and will again be held in an interesting environment, perhaps in combination with a tour of a demolition project. (orig.)

  20. Proceedings of the 2008 marine biodiesel symposium

    International Nuclear Information System (INIS)

    2008-01-01

    In addition to producing lower hydrocarbon emissions, marine biodiesel is biodegradable and does not harm fish. This symposium was held to discuss current marine biodiesel applications and examine methods of increasing the use of biodiesel in marine environments in British Columbia (BC). Biofuel policies and mandates in the province were reviewed, and methods of expanding the biodiesel market were explored. Updates on the use of biodiesel in ferries, tugboats, and smaller marine diesel engine applications were provided. Biodiesel projects in the United States were discussed. The environmental impacts of marine biodiesel were evaluated, and federal policies and standards for biodiesel were also outlined. The symposium was divided into the following 5 main sessions: (1) policy, (2) overviews, (3) using biodiesel in marine engines, (4) biodiesel in larger marine vessels, and (5) biodiesel quality and environmental considerations. The conference featured 13 presentations, of which 4 have been catalogued separately for inclusion in this database. tabs., figs

  1. International symposium on marine pollution. Extended synopses

    International Nuclear Information System (INIS)

    1998-01-01

    The marine environment - understanding and protecting for the future were at the forefront of the International Symposium on Marine Pollution convened in Monaco from 5 to 9 October 1998, as one of the major events of the UN International Year of the Oceans. New achievements were reported in identifying the sources of pollution, on the behaviour and fate of contaminants in seawater, biota and sediments, on the use of radioactive and non-radioactive tracers for studies of transport and circulation processes in the world's oceans and seas, on studies of radioactive waste dumping sites and nuclear weapons test sites, on local, regional and global computer modelling of the transport of contaminants and on many other topics in marine pollution. New developments in high sensitivity analytical measurements of contaminants with emphasis on nuclear and isotopic methods were also presented. This document contains extended synopses of 390 oral and poster presentations made at the symposium. Each synopsis was indexed separately

  2. PREFACE: XXXV Symposium on Nuclear Physics

    Science.gov (United States)

    Padilla-Rodal, E.; Bijker, R.

    2012-09-01

    Conference logo The XXXV Symposium on Nuclear Physics was held at Hotel Hacienda Cocoyoc, Morelos, Mexico from January 3-6 2012. Conceived in 1978 as a small meeting, over the years and thanks to the efforts of various organizing committees, the symposium has become a well known international conference on nuclear physics. To the best of our knowledge, the Mexican Symposium on Nuclear Physics represents the conference series with longest tradition in Latin America and one of the longest-running annual nuclear physics conferences in the world. The Symposium brings together leading scientists from all around the world, working in the fields of nuclear structure, nuclear reactions, physics with radioactive ion beams, hadronic physics, nuclear astrophysics, neutron physics and relativistic heavy-ion physics. Its main goal is to provide a relaxed environment where the exchange of ideas, discussion of new results and consolidation of scientific collaboration are encouraged. To celebrate the 35th edition of the symposium 53 colleagues attended from diverse countries including: Argentina, Australia, Canada, Japan, Saudi Arabia and USA. We were happy to have the active participation of Eli F Aguilera, Eduardo Andrade, Octavio Castaños, Alfonso Mondragón, Stuart Pittel and Andrés Sandoval who also participated in the first edition of the Symposium back in 1978. We were joined by old friends of Cocoyoc (Stuart Pittel, Osvaldo Civitarese, Piet Van Isacker, Jerry Draayer and Alfredo Galindo-Uribarri) as well as several first time visitors that we hope will come back to this scientific meeting in the forthcoming years. The scientific program consisted of 33 invited talks, proposed by the international advisory committee, which nicely covered the topics of the Symposium giving a balanced perspective between the experimental and the theoretical work that is currently underway in each line of research. Fifteen posters complemented the scientific sessions giving the opportunity

  3. 15th International Symposium of Robotic Research

    CERN Document Server

    Khatib, Oussama

    2017-01-01

    This volume presents a collection of papers presented at the 15th International Symposium of Robotic Research (ISRR). ISRR is the biennial meeting of the International Foundation of Robotic Research (IFRR) and its 15th edition took place in Flagstaff, Arizona on December 9 to December 12, 2011. As for the previous symposia, ISRR 2011 followed up on the successful concept of a mixture of invited contributions and open submissions. Therefore approximately half of the 37 contributions were invited contributions from outstanding researchers selected by the IFRR officers and the program committee, and the other half were chosen among the open submissions after peer review. This selection process resulted in a truly excellent technical program which featured some of the very best of robotic research. The program was organized around oral presentation in a single-track format and included for the first time a small number of interactive presentations. The symposium contributions contained in this volume report on a ...

  4. Proceedings of the symposium on leukemia clustering

    International Nuclear Information System (INIS)

    Elaguppillai, V.; Goyette, J.P.; Osborne, R.V.

    1992-07-01

    Clusters of leukemia in populations living in specific locations in various countries have been examined by scientific and medical experts for many years. In general, the reason for the existence of these clusters is unknown. The recent discovery of a small cluster of leukemias among children who were born in the vicinity of a nuclear fuel reprocessing facility in England has stimulated wide interest in the possible occurrence of clusters of leukemia around nuclear facilities. The purpose of this symposium was to present scientific evidence concerning the existence of leukemia clusters in the population, to discuss possible causes for these clusters and to suggest directions for future research. Distinguished speakers from Canada, the United Kingdom, Germany, Italy and the U.S.A. participated in this symposium. (author)

  5. John B. Little Center Annual Symposium

    International Nuclear Information System (INIS)

    Demple, Bruce F.

    2007-01-01

    The Annual Symposium of the John B. Little Center for Radiation Sciences and Environmental Health at the Harvard School of Public Health seeks to educate radiobiologists and biomedical scientists in related areas on the leading research related to the effects of ionizing radiation and related environmental agents in biological systems. This effort seeks to further the training of individuals in this field, and to foment productive interactions and collaborations among scientists at Harvard and with other institutions. The Symposium attracts world-class scientists as speakers, and a broad cross-section of attendees from academic, government, and industrial research centers, as well as editorial staff from leading scientific publications. In order to maintain this quality, funding to support the travel and local expenses of invited speakers is sought, along with funds to allow use of appropriate conference facilities.

  6. CSP- 5th Champalimaud Neuroscience Symposium

    Science.gov (United States)

    2017-03-20

    4 Participants also had the opportunity to interact with scientific editors from the journals Nature and Nature Neuroscience . This has led to...multiple articles based on work presented at the symposium being submitted for publication to these journals . Feedback from participants Based on a...media attention. It was covered both on national TV and also in major magazines in Portugal. For example: RTP http :1/www. rtp . pUnoticias/m undo

  7. Eleventh international symposium on radiopharmaceutical chemistry

    International Nuclear Information System (INIS)

    1995-01-01

    This document contains abstracts of papers which were presented at the Eleventh International Symposium on Radiopharmaceutical Chemistry. Sessions included: radiopharmaceuticals for the dopaminergic system, strategies for the production and use of labelled reactive small molecules, radiopharmaceuticals for measuring metabolism, radiopharmaceuticals for the serotonin and sigma receptor systems, labelled probes for molecular biology applications, radiopharmaceuticals for receptor systems, radiopharmaceuticals utilizing coordination chemistry, radiolabelled antibodies, radiolabelling methods for small molecules, analytical techniques in radiopharmaceutical chemistry, and analytical techniques in radiopharmaceutical chemistry

  8. Eleventh international symposium on radiopharmaceutical chemistry

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    This document contains abstracts of papers which were presented at the Eleventh International Symposium on Radiopharmaceutical Chemistry. Sessions included: radiopharmaceuticals for the dopaminergic system, strategies for the production and use of labelled reactive small molecules, radiopharmaceuticals for measuring metabolism, radiopharmaceuticals for the serotonin and sigma receptor systems, labelled probes for molecular biology applications, radiopharmaceuticals for receptor systems, radiopharmaceuticals utilizing coordination chemistry, radiolabelled antibodies, radiolabelling methods for small molecules, analytical techniques in radiopharmaceutical chemistry, and analytical techniques in radiopharmaceutical chemistry.

  9. PREFACE: The International Symposium on Atomic Technology

    Science.gov (United States)

    Shirai, Yasuharu

    2008-03-01

    The International Symposium on Atomic Technology (ISAT) is held every year. The Second Symposium (ISAT-2) was held on 1-2 October 2007 at the Awaji Yumebutai Conference Center, Awaji City, Japan presided by the `Atomic Technology Project'. The ISAT-2 symposium was intended to offer a forum for the discussion of the latest progress in atomic technologies. The symposium was attended by 106 delegates. There were 9 invited and 5 oral presentations. The number of poster presentations was 73. From all the contributions, 24 papers selected through review process are contained in this volume. The `Atomic Technology Project' was started in 2006 as a joint project of three institutions; (1) Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University (CAMT), (2) Tsukuba Research Center for Interdisciplinary Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba (TIMS) and (3) Polyscale Technology Research Center, Research Institute for Science and Technology, Tokyo University of Science (PTRC), each of which were independently pursuing nano-technologies and were developing atomic scale operation and diagnostics, functional materials, micro processing and devices. The project is funded by the Ministry of Education, Culture, Sports, Science and Technology of Japan. The goal of the project is to contribute to the development of atomic-scale science and technologies such as functional molecules, biomaterials, and quantum functions of atomic-scale structures. Yasuharu Shirai Conference Chair Center for Atomic Technologies, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita-city, Osaka 565-0871, Japan. Conference photograph

  10. PREFACE: XXXIV Symposium on Nuclear Physics

    Science.gov (United States)

    Barrón-Palos, Libertad; Bijker, Roelof

    2011-10-01

    In the present volume of the Journal of Physics: Conference Series we publish the proceedings of the 'XXXIV Symposium on Nuclear Physics', which was held from 4-7 January 2011 at the Hacienda Cocoyoc, Morelos, Mexico. The proceedings consist of 19 contributions that were presented as invited talks at the meeting. The abstracts of all contributions, plenary talks and posters were published in the Conference Handbook. The Symposium on Nuclear Physics has a long and distinguished history. From the beginning it was intended to be a relatively small meeting designed to bring together some of the leading nuclear scientists in the field. Its most distinctive feature is to provide a forum for specialists in different areas of nuclear physics, both theorists and experimentalists, students, postdocs and senior scientists, in a relaxed and informal environment providing them with a unique opportunity to exchange ideas. From the first meeting in Oaxtepec in 1978, the Symposium has been organized every year without interruption, which makes the present Symposium the 34th in a row. The scientific program consisted of 27 invited talks and 17 posters on a wide variety of hot topics in contemporary nuclear physics, ranging from the traditional fields of nuclear structure (Draayer, Pittel, Van Isacker, Fraser, Lerma, Cejnar, Hirsch, Stránský and Rath) and nuclear reactions (Aguilera, Gómez-Camacho, Scheid, Navrátil and Yennello) to radioactive beams (Padilla-Rodal and Galindo-Uribarri), nuclear astrophysics (Aprahamian, Civitarese and Escher), hadronic physics (Bijker, Valcarce and Hess), fundamental symmetries (Liu, Barrón-Palos and Baessler) and LHC physics (Menchaca-Rocha and Paic). The high quality of the talks, the prestige of the speakers and the broad spectrum of subjects covered in the meeting, shows that nuclear physics is a very active area at the frontier of scientific research which establishes bridges between many different disciplines. Libertad Barr

  11. 2012 Symposium on Chaos, Complexity and Leadership

    CERN Document Server

    Erçetin, Şefika

    2014-01-01

    These proceedings from the 2012 symposium on "Chaos, complexity and leadership"  reflect current research results from all branches of Chaos, Complex Systems and their applications in Management. Included are the diverse results in the fields of applied nonlinear methods, modeling of data and simulations, as well as theoretical achievements of Chaos and Complex Systems. Also highlighted are  Leadership and Management applications of Chaos and Complexity Theory.

  12. Proceedings of the DMS medical ethics symposium.

    Science.gov (United States)

    O'Reilly, D J

    2011-12-01

    This article presents the proceedings of a symposium on medical ethics held at the Royal Centre for Defence Medicine in October 2010. The nature of current operations continually generates challenging ethical problems, many of which are unique to the military environment. This article is intended to generate a debate on these difficult issues and readers are encouraged to contribute to this debate by emailing the Editor.

  13. Biology of the White Shark, a Symposium

    OpenAIRE

    Sibley, Gretchen editor

    1985-01-01

    Sixteen papers were presented during the symposium and asterisks denote the names of authors who have contributed to this volume. Leonard Compagno began with an overview of white shark biology and anatomy followed by Shelton Applegate and Luis Espinosa who presented two papers dealing with the fossil history of the white shark and implications concerning the habits and present status of the recent species. Peter Klimley* and Wes Pratt* and Jack Casey* presented papers on the distribution of w...

  14. Assessing a Science Graduate School Recruitment Symposium.

    Science.gov (United States)

    González-Espada, Wilson; Díaz-Muñoz, Greetchen; Feliú-Mójer, Mónica; Flores-Otero, Jacqueline; Fortis-Santiago, Yaihara; Guerrero-Medina, Giovanna; López-Casillas, Marcos; Colón-Ramos, Daniel A; Fernández-Repollet, Emma

    2015-12-01

    Ciencia Puerto Rico, a non-profit organization dedicated to promoting science, research and scientific education among Latinos, organized an educational symposium to provide college science majors the tools, opportunities and advice to pursue graduate degrees and succeed in the STEM disciplines. In this article we share our experiences and lessons learned, for others interested in developing large-scale events to recruit underrepresented minorities to STEM and in evaluating the effectiveness of these efforts.

  15. Assessing a Science Graduate School Recruitment Symposium

    Science.gov (United States)

    González-Espada, Wilson; Díaz-Muñoz, Greetchen; Feliú-Mójer, Mónica; Flores-Otero, Jacqueline; Fortis-Santiago, Yaihara; Guerrero-Medina, Giovanna; López-Casillas, Marcos; Colón-Ramos, Daniel A.; Fernández-Repollet, Emma

    2015-01-01

    Ciencia Puerto Rico, a non-profit organization dedicated to promoting science, research and scientific education among Latinos, organized an educational symposium to provide college science majors the tools, opportunities and advice to pursue graduate degrees and succeed in the STEM disciplines. In this article we share our experiences and lessons learned, for others interested in developing large-scale events to recruit underrepresented minorities to STEM and in evaluating the effectiveness of these efforts. PMID:26770074

  16. IAEA symposium on international safeguards. Extended synopses

    International Nuclear Information System (INIS)

    1997-10-01

    The most important subjects treated in 188 papers presented by the participants from member state and IAEA Safeguards Inspectors at the Symposium were as follows: implementation of IAEA safeguards; national support programs to the IAEA safeguards; experiences in application of safeguard monitoring devices; improved methods for verification of plutonium; highly enriched uranium; surveillance of spent fuel storage facilities, reprocessing plants, fuel fabrication plants; excess weapon grade plutonium and other fissile materials

  17. Sixth underground coal-conversion symposium

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    The sixth annual underground coal conversion symposium was held at Shangri-la near Afton, Oklahoma, July 13 to 17, 1980. Sessions were developed to: Doe Field Programs, Major Industry Activity, Mathematical Modeling, Laboratory Studies, Environmental Studies, Economics, Instruments and Controls, and General Topics. Fifty-two papers from the proceedings have been entered individually into EDB and ERA. Thirteen papers had been entered previously from other sources. (LTN)

  18. PREFACE: Fourth International Symposium on Atomic Technology

    Science.gov (United States)

    Okada, Shigefumi

    2010-04-01

    The International Symposium on Atomic Technology (ISAT) is held every year. The 4th Symposium (ISAT-4) was held on November 18-19, 2009 at the Seaside Hotel MAIKO VILLA KOBE, Kobe City, Japan presided by the "Atomic Technology Project". The ISAT-4 symposium was intended to offer a forum for the discussion on the latest progress in the atomic technologies. The symposium was attended by 107 delegates. There were 10 invited and 6 oral presentations. The number of poster presentations was 69. From all the contributions, 22 papers selected through review process are contained in this volume. The "Atomic Technology Project" was started in 2006 as a joint project of three institutions; (1) the Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University (CAMT), (2) the Tsukuba Research Center for Interdisciplinary Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba (TIMS) and (3) the Polyscale Technology Research Center, Research Institute for Science and Technology, Tokyo University of Science (PTRC), each of which were independently pursuing nano-technologies and was developing atomic scale operation and diagnostics, functional materials, micro processing and device. The project is funded by the Ministry of Education, Culture, Sports, Science and Technology of Japan. The goal of the project is to contribute to the development of atomic-scale science and technologies such as functional molecules, biomaterials, and quantum functions of atomic-scale structures. Shigefumi Okada Conference Chair Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita-city, Osaka 565-0871, Japan. Conference photograph Kobe photograph

  19. Collaborative Care Transitions Symposium: Insights from Participants.

    Science.gov (United States)

    Jeffs, Lianne; Saragosa, Marianne; Zahradnik, Michelle; Maione, Maria; Hindle, Aimee; Santiago, Cecilia; Krock, Murray; Stergiopoulos, Vicky; Bulmer, Beverly; Mitchell, Kaleil; McNamee, Colleen; Ramji, Noor

    2017-01-01

    There are promising signs that interprofessional collaborative practice is associated with quality care transitions and improved access to patient-centred healthcare. A one-day symposium was held to increase awareness and capacity to deliver quality collaborative care transitions to interprofessional health disciplines and service users. A mixed methods study was used that included a pre-post survey design and interviews to examine the impact of the symposium on knowledge, attitudes and practice change towards care transitions and collaborative practice with symposium participants. Our survey results revealed a statistically significant increase in only a few of the scores towards care transitions and collaborative practice among post-survey respondents. Three key themes emerged from the qualitative analysis, including: (1) engaging the patient at the heart of interprofessional collaboration and co-design of care transitions; (2) having time to reach out, share and learn from each other; and (3) reflecting, reinforcing and revising practice. Further efforts that engage inter-organizational learning by exchanging knowledge and evaluating these forums are warranted. Copyright © 2017 Longwoods Publishing.

  20. Proceedings of KURRI symposium on criticality safety

    International Nuclear Information System (INIS)

    Nishina, Kojiro; Kanda, Keiji

    1984-01-01

    On August 8, 1984, at the Reactor Application Center of the Research Reactor Institute, Kyoto University, the symposium on criticality safety was held, and 81 participants from various fields of reactor physics, nuclear fuel cycle engineering, reactor chemistry, nuclear chemistry, health physics and so on discussed the problem. The gists of the presentation are collected in this report. The contents are the techniques of evaluating criticality safety in respective fuel facilities, the system of control and its concept, the course and plan of the research on criticality safety in Japan and foreign countries, the techniques of determining multiplication factor and so on, and the review of present status, the pointing-out of problems and the report of new techniques were made. The measures coping with criticality safety have been mostly to meet urgent demand, but its fundamental examination and long term research should be carried out. This symposium was planned as the preparation for such research project, and favorable comment was given by the participants. In the next symposium, it is considered better to limit the themes and to allot more time to respective lectures. (Kako, I.)

  1. PREFACE: XXXVII Symposium on Nuclear Physics

    Science.gov (United States)

    Bijker, R.; Lerma, S.; Lizcano, D.

    2015-01-01

    The Symposium on Nuclear Physics is an international meeting organized every year since 1978 by the Division of Nuclear Physics of the Mexican Physical Society. The 37th edition was held at the Hotel Hacienda Cocoyoc in the state of Morelos, Mexico, from 6-9 January, 2014. The symposium is intended to be a relatively small meeting designed to bring together some of the leading nuclear scientists in different areas of nuclear physics (nuclear astrophysics, nuclear structure, neutrino physics, hadron physics and nuclear reactions among others). Both theorists and experimentalists, students, postdocs and senior scientists gathered in a relaxed and informal environment providing them with a unique opportunity to exchange ideas. The symposium was organized in plenary sessions with invited talks and a poster session. In this edition the program consisted of 26 invited talks and 19 posters, whose subjects reflected the active areas and interests of the mexican nuclear physics community. The organization encouraged the participation of young scientist as speakers in the plenary sessions. Seven of the 26 invited talks were given by postdoctoral and doctoral students working in different institutions from Mexico, USA and Europe. The proceedings collect a total of 16 manuscripts from the invited speakers.

  2. Tenth annual underground coal gasification symposium: proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Burwell, E.; Docktor, L.; Martin, J.W. (eds.)

    1984-12-01

    The Tenth Annual Underground Coal Gasification Symposium was cosponsored by the Fossil Energy Division of the US Department of Energy and the Morgantown Energy Technology Center's Laramie Projects Office. The purpose of the symposium was to provide a forum for presenting research results and for determining additional research needs in underground coal gasification. This years' meeting was held in Williamsburg, Virginia, during the week of August 12 through 15, 1984. Approximately 120 attendees representing industry, academia, national laboratories, Government, and eight foreign countries participated in the exchange of ideas, results, and future research plans. International representatives included participants from Belgium, Brazil, France, the Netherlands, New Zealand, Spain, West Germany, and Yugoslavia. During the three-day symposium, sixty papers were presented and discussed in four formal presentation sessions and two informal poster sessions. The papers describe interpretation of field test data, results of environmental research, and evaluations of laboratory, modeling, and economic studies. All papers in this Proceedings have been processed for inclusion in the Energy Data Base.

  3. Land Subsidence International Symposium held in Venice

    Science.gov (United States)

    The Third International Symposium on Land Subsidence was held March 18-25, 1984, in Venice, Italy. Sponsors were the Ground-Water Commission of the International Association of Hydrological Sciences (IAHS), the United Nations Educational, Scientific, and Cultural Organization (UNESCO), the Italian National Research Council (CNR), the Italian Regions of Veneto and Emilia-Romagna, the Italian Municipalities of Venice, Ravenna, and Modena, the Venice Province, and the European Research Office. Cosponsors included the International Association of Hydrogeologists (IAH), the International Society for Soil Mechanics and Foundation Engineering (ISSMFE), and the Association of Geoscientists for International Development (AGID).Organized within the framework of UNESCO's International Hydrological Program, the symposium brought together over 200 international interdisciplinary specialists in the problems of land subsidence due to fluid and mineral withdrawal. Because man's continuing heavy development of groundwater, gas, oil, and minerals is changing the natural regime and thus causing more and more subsiding areas in the world, there had been sufficient new land subsidence occurrence, problems, research, and remedial measures since the 1976 Second International Symposium held in Anaheim, California, to develop a most interesting program of nearly 100 papers from about 30 countries. The program consisted of papers covering case histories of fluid and mineral withdrawal, engineering theory and analysis, karst “sink-hole”-type subsidence, subsidence due to dewatering of organic deposits or due to application of water (hydrocompaction), instrumentation, legal, socioeconomic, and environmental effects of land subsidence, and remedial works.

  4. Introduction to the Paper Symposium

    Science.gov (United States)

    Carpenter, D. K.

    1996-05-01

    Most students of physical chemistry, as well as their teachers, regard equilibrium chemical thermodynamics as an impressive, useful, and stable subject that was "finished" long ago. As part of their education, students in physical chemistry have been taught the importance and the usefulness of the Gibbs function (formerly called the Gibbs free energy function). The antiquity of the subject and the presumed mastery of its basics by physical chemistry teachers are taken for granted as given parts of the educational and scientific scene in chemical education. It comes as a surprise to occasionally discover that even those who teach this venerable subject sometimes disagree, not merely in matters of style or organization of the subject, or in matters of mathematical elegance, but in matters of real substance. The following four papers are examples of this. My role here is simply to introduce this set of papers and to provide some orientation regarding their contents. The authors have been in private communication with each other for a period of over four years about the use and the proper definition of the Gibbs function. The lengthy period of correspondence has not resulted in any significant agreement. The Editor of this Journal was unable to settle the resulting controversy by normal review procedures. In an attempt to break the deadlock he asked me, as an impartial outsider to the situation, for assistance in deciding an appropriate literary form in which the authors could present their own points of view as well as comments on the views of the other authors. The original hope was that agreement could eventually be reached on disputed points by the give and take of the interchange of further correspondence, and that the outcome would be published in the form of a "paper symposium" on the subject, with me as the "chairman" of the symposium. It must be said at the outset that the prolonged correspondence has not produced much agreement among the authors. This is

  5. PREFACE: Nobel Symposium 129 on Neutrino Physics

    Science.gov (United States)

    Bergström, Lars; Botner, Olga; Carlson, Per; Hulth, Per Olof; Ohlsson, Tommy

    2005-01-01

    Nobel Symposium 129 on Neutrino Physics was held at Haga Slott in Enköping, Sweden during August 19 24, 2004. Invited to the symposium were around 40 globally leading researchers in the field of neutrino physics, both experimental and theoretical. In addition to these participants, some 30 local researchers and graduate students participated in the symposium. The dominant theme of the lectures was neutrino oscillations, which after several years were recently verified by results from the Super-Kamiokande detector in Kamioka, Japan and the SNO detector in Sudbury, Canada. Discussion focused especially on effects of neutrino oscillations derived from the presence of matter and the fact that three different neutrinos exist. Since neutrino oscillations imply that neutrinos have mass, this is the first experimental observation that fundamentally deviates from the standard model of particle physics. This is a challenge to both theoretical and experimental physics. The various oscillation parameters will be determined with increased precision in new, specially designed experiments. Theoretical physics is working intensively to insert the knowledge that neutrinos have mass into the theoretical models that describe particle physics. It will probably turn out that the discovery of neutrino oscillations signifies a breakthrough in the description of the very smallest constituents of matter. The lectures provided a very good description of the intensive situation in the field right now. The topics discussed also included mass models for neutrinos, neutrinos in extra dimensions as well as the `seesaw mechanism', which provides a good description of why neutrino masses are so small. Also discussed, besides neutrino oscillations, was the new field of neutrino astronomy. Among the questions that neutrino astronomy hopes to answer are what the dark matter in the Universe consists of and where cosmic radiation at extremely high energies comes from. For this purpose, large neutrino

  6. Trombay symposium on radiation and photochemistry. Preprints volume

    International Nuclear Information System (INIS)

    The Trombay Symposium on Radiation and Photochemistry was held during January 8-12, 1996 in Bombay. The invited lectures as well as contributed papers in the symposium deal with front-line thrust areas in radiation and photochemistry. Papers relevant to INIS are indexed separately. refs., figs., tabs

  7. Proceedings of the 13th symposium on advanced photon research

    International Nuclear Information System (INIS)

    2013-09-01

    The 13th Symposium on Advanced Photon Research was held at Kansai Photon Science Institute, Japan Atomic Energy Agency (JAEA-KPSI) in Kizugawa-shi, Kyoto on November 15 - 16, 2012. This report consists of invited and contributed papers presented at the oral and poster sessions in the Symposium. (author)

  8. Editorial: International Symposium on Inorganic and Environmental Materials (ISIEM 2004)

    NARCIS (Netherlands)

    Winnubst, Aloysius J.A.; Itatani, Kiyoshi; Hintzen, Bert; Metselaar, Ruud; Sango, Hiroyuki

    2006-01-01

    The first ideas on organizing a combined Japanese–Dutch symposium on Inorganic Materials were born in 2003. It was a follow-up of a long running cooperation between the Sophia University, Tokyo (Kiyoshi Itatani) and the Eindhoven University of Technology (Bert Hintzen). This symposium was intended

  9. Comparative gut physiology symposium: The microbe-gut-brain axis

    Science.gov (United States)

    The Comparative Gut Physiology Symposium titled “The Microbe-Gut-Brain Axis” was held at the Joint Annual Meeting of the American Society of Animal Science and the American Dairy Science Association on Thursday, July 21, 2016, in Salt Lake City Utah. The goal of the symposium was to present basic r...

  10. Persuasive Writing and the Student-Run Symposium

    Science.gov (United States)

    Mayer, James C.

    2007-01-01

    High school teacher James C. Mayer explains how a student-run symposium can promote "risk-taking and participation" and help students practice effective persuasion skills before demonstrating them in writing. The symposium places students in roles that encourage responsibility and ownership for discussion and learning, shifting the classroom…

  11. Proceedings of DAE-BRNS national symposium on Limnology

    International Nuclear Information System (INIS)

    Venkataramani, B.; Puranik, V.D.; Apte, S.K.; Gour, H.N.; Sharma, S.K.; Sharma, L.L.; Sharma, B.K.; Gupta, H.C.L.; Verma, P.C.

    2007-01-01

    The present symposium NSL addresses both the basic and applied aspects of limnology. The outcome of the symposium will help in the formulation of water policy that will result in the sustained availability of healthy fresh water resources and also benefit the industrial end user. Papers relevant to INIS are indexed separately

  12. Verslag symposium : "M€€r welzijn zonder pijn"

    NARCIS (Netherlands)

    Driesse, M.; Kluivers-Poodt, M.

    2010-01-01

    Op 27 april 2010 hield men in Lelystad het symposium 'Meer welzijn zonder pijn' over het thema welzijn bij landbouwhuisdieren, georganiseerd door Wageningen UR Livestock Research in samenwerking met Boehringer Ingelheim. Hoewel het symposium primair bedoeld was voor rundvee- en varkensdierenartsen,

  13. Proceedings of the symposium on molecular biology and radiation protection

    International Nuclear Information System (INIS)

    Marko, A.M.

    1996-02-01

    The symposium on molecular biology and radiation protection was organized in sessions with the following titles: Radiation protection and the human genome; Molecular changes in DNA induced by radiation; Incidence of genetic changes - pre-existing, spontaneous and radiation-induced; Research directions and ethical implications. The ten papers in the symposium have been abstracted individually

  14. 76 FR 17137 - Pregnancy and Prescription Medication Use Symposium

    Science.gov (United States)

    2011-03-28

    ...] Pregnancy and Prescription Medication Use Symposium AGENCY: Food and Drug Administration, HHS. ACTION... and Prescription Medication Use Symposium. The topic to be discussed is ``Prescription Drug Use in... be any transcripts; however, the speakers' Power Point presentations will be posted on the FDA/OWH...

  15. Proceedings of the 9th symposium on advanced photon research

    International Nuclear Information System (INIS)

    2010-03-01

    The 9th Symposium on Advanced Photon Research was held at Kansai Photon Science Institute, Japan Atomic Energy Agency (JAEA-KPSI) in Kizugawa, Kyoto on July 31- August 1, 2008. This report consists of invited and contributed papers presented at the oral and poster sessions in The Symposium. The 25 of the presented papers are indexed individually. (J.P.N.)

  16. Overview of the 8th International Symposium on Vulcanospeleology

    Directory of Open Access Journals (Sweden)

    Halliday William R.

    1998-01-01

    Full Text Available In February 1998 the 8h International Symposium on Vulcanospeleology was hosted by CEGEA (Cave Exploration Group of East Africa in Nairobi, Kenya: it was attended by 16 scientists coming from 4 continents. Pre- and Post- Symposium excursions allowed the participants to have an overview on the most important and famous volcanic cave of that area.

  17. Highlight: IDRC sponsors Caribbean symposium on impact of ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2015-05-12

    12 mai 2015 ... An IDRC-sponsored symposium exploring the impact of the Internet on economic growth and public service delivery in the Caribbean was held in Saint Andrew, Jamaica, on May 12, 2015. Discussions from the symposium will feed into the 2016 World Development Report: Internet for Development.

  18. Go Tell Alcibiades: Tragedy, Comedy, and Rhetoric in Plato's "Symposium"

    Science.gov (United States)

    Crick, Nathan; Poulakos, John

    2008-01-01

    Plato's "Symposium" is a significant but neglected part of his elaborate and complex attitude toward rhetoric. Unlike the intellectual discussion of the "Gorgias" or the unscripted conversation of the "Phaedrus," the "Symposium" stages a feast celebrating and driven by the forces of "Eros." A luxuriously stylish performance rather than a rational…

  19. Nuclear fusion: Pursuing the Soft [Symposium on fusion technology] option

    International Nuclear Information System (INIS)

    Kenward, M.

    1991-01-01

    Fusion research has come a long way since the fusion community held the first Symposium on fusion technology (Soft) in Britain 30 years ago. Some of the recent achievements of the Jet project are reported from this year's symposium, the 16th in the series, held in London at the beginning of September. (author)

  20. 21st DAE-BRNS High Energy Physics Symposium 2014

    CERN Document Server

    DAE-HEP 2014

    2014-01-01

    The DAE-BRNS High Energy Physics Symposium is a conference series held every other year in India, supported by the Board of Research in Nuclear Sciences (BRNS), Department of Atomic Energy (DAE), India. The symposium is considered as one of the premiere symposiums organized in India in the field of elementary particle physics. Around 350 physicists and researchers are expected to participate in this symposium to discuss the latest advancements in the fields of particle physics, astro-particle physics, cosmology, development of new detector technology and accelerator. The XXI edition of the DAE-BRNS High Energy Physics Symposium will be held in the picturesque campus of the Indian Institute of Technology Guwahati during 8 – 12 December, 2014.

  1. Organizational Change. Symposium 11. [Concurrent Symposium Session at AHRD Annual Conference, 2000.

    Science.gov (United States)

    2000

    This packet contains three papers from a symposium on organizational change. The first paper, "Kaizen Blitz: Rapid Learning to Facilitate Immediate Organizational Improvements" (Robert B. Gudgel, Fred C. Feitler), describes rapid and dramatic improvement in the organizational performance of a manufacturing firm after use of a series of…

  2. Macrocephaly, epilepsy, autism, dysmorphic features, and mental retardation in two sisters: a new autosomal recessive syndrome?

    OpenAIRE

    Orstavik, K H; Strømme, P; Ek, J; Torvik, A; Skjeldal, O H

    1997-01-01

    We report two sisters with macrocephaly, epilepsy, and severe mental retardation. The first child was a 14 year old girl born at term after a normal pregnancy, with birth weight 3600 g and occipitofrontal circumference (OFC) 36 cm (75th centile). Her head size increased markedly during the first six months of life, and was later stable at 2-3 cm above the 97.5th centile. Her development was characterised by psychomotor delay, epilepsy, and autistic features. Her face appeared mildly dysmorphi...

  3. Mitochondrial Genes Reveal Triatoma jatai as a Sister Species to Triatoma costalimai (Reduviidae: Triatominae).

    Science.gov (United States)

    Teves, Simone Caldas; Gardim, Sueli; Carbajal de la Fuente, Ana Laura; Lopes, Catarina Macedo; Gonçalves, Teresa Cristina Monte; dos Santos Mallet, Jacenir Reis; da Rosa, João Aristeu; Almeida, Carlos Eduardo

    2016-03-01

    Triatoma jatai was described using a set of morphological structures from specimens collected in Paranã municipality of Tocantins State, Brazil. Under a Bayesian framework and using two mitochondrial genes (16S and COI), phylogenetic analysis recovered T. jatai as a sister species to Triatoma costalimai with higher genetic distances than between other well-recognized species. Our results agree with previous suggestions based on morphometric analysis. In the light of the non-monophyly of Matogrossensis subcomplex, the inclusion of T. jatai shall be considered for reevaluating this group. © The American Society of Tropical Medicine and Hygiene.

  4. Diet transiently improves migraine in two twin sisters: possible role of ketogenesis?

    Science.gov (United States)

    Di Lorenzo, Cherubino; Currà, Antonio; Sirianni, Giulio; Coppola, Gianluca; Bracaglia, Martina; Cardillo, Alessandra; De Nardis, Lorenzo; Pierelli, Francesco

    2013-01-01

    The ketogenic diet is a high-fat, low-carbohydrate diet long used to treat refractory epilepsy; ketogenesis (ketone body formation) is a physiological phenomenon also observed in patients following lowcarbohydrate, low-calorie diets prescribed for rapid weight loss. We report the case of a pair of twin sisters, whose high-frequency migraine improved during a ketogenic diet they followed in order to lose weight. The observed time-lock between ketogenesis and migraine improvement provides some insight into how ketones act to improve migraine.

  5. Wing base structural data support the sister relationship of megaloptera and neuroptera (insecta: neuropterida.

    Directory of Open Access Journals (Sweden)

    Chenjing Zhao

    Full Text Available The phylogenetic status and the monophyly of the holometabolous insect order Megaloptera has been an often disputed and long unresolved problem. The present study attempts to infer phylogenetic relationships among three orders, Megaloptera, Neuroptera, and Raphidioptera, within the superorder Neuropterida, based on wing base structure. Cladistic analyses were carried out based on morphological data from both the fore- and hindwing base. A sister relationship between Megaloptera and Neuroptera was recovered, and the monophyly of Megaloptera was corroborated. The division of the order Megaloptera, the traditional higher classification, into Corydalidae (Corydalinae + Chauliodinae and Sialidae, was also supported by our wing base data analyses.

  6. Emergence of ethnochoreology internationally: The Janković sisters, Maud Karpeles, and Gertrude Kurath

    Directory of Open Access Journals (Sweden)

    Dunin Elsie Ivancich

    2014-01-01

    Full Text Available A fifty-year (1962-2012 period has been shown as a history of ethnochoreology supported by living memories of members of the International Council for Traditional Music (ICTM Study Group on Ethnochoreology. Recently uncovered and juxtapositioned correspondence of three predecessors within earlier years of the International Folk Music Council (IFMC broadens the history. This article reveals the emergence of ethnochoreology during the 1950s with publications of the two Janković sisters in Serbia with that of Gertrude Kurath in the United States, alongside correspondence with Maud Karpeles, the unheralded founder of the IFMC.

  7. [Partial lipodystrophy in two HLA identical sisters with hypocomplementemia and nephropathy].

    Science.gov (United States)

    Peces, R

    2002-01-01

    Partial lipodystrophy is a rare disorder with both autosomal recessive and familial forms. The cutaneous findings, which are often subtle, consist of gradual loss of subcutaneous fat from the face and upper body. Low levels of C3 and the presence of C3NeF help to identify these patients. Associated systemic abnormalities include the development of membranoproliferative glomerulonephritis, insulin resistance and an increased incidence of autoimmune diseases. We report here two HLA identical sisters with the typical features of partial lipodystrophy associated with recurrent infections, low levels of C3, and nephropathy. Our data suggest an autosomal recessive transmission. We discuss the genetic and molecular basis of this rare association.

  8. Compound heterozygous mutations in UBA5 causing early-onset epileptic encephalopathy in two sisters.

    Science.gov (United States)

    Arnadottir, Gudny A; Jensson, Brynjar O; Marelsson, Sigurdur E; Sulem, Gerald; Oddsson, Asmundur; Kristjansson, Ragnar P; Benonisdottir, Stefania; Gudjonsson, Sigurjon A; Masson, Gisli; Thorisson, Gudmundur A; Saemundsdottir, Jona; Magnusson, Olafur Th; Jonasdottir, Adalbjorg; Jonasdottir, Aslaug; Sigurdsson, Asgeir; Gudbjartsson, Daniel F; Thorsteinsdottir, Unnur; Arngrimsson, Reynir; Sulem, Patrick; Stefansson, Kari

    2017-10-02

    Epileptic encephalopathies are a group of childhood epilepsies that display high phenotypic and genetic heterogeneity. The recent, extensive use of next-generation sequencing has identified a large number of genes in epileptic encephalopathies, including UBA5 in which biallelic mutations were first described as pathogenic in 2016 (Colin E et al., Am J Hum Genet 99(3):695-703, 2016. Muona M et al., Am J Hum Genet 99(3):683-694, 2016). UBA5 encodes an activating enzyme for a post-translational modification mechanism known as ufmylation, and is the first gene from the ufmylation pathway that is linked to disease. We sequenced the genomes of two sisters with early-onset epileptic encephalopathy along with their unaffected parents in an attempt to find a genetic cause for their condition. The sisters, born in 2004 and 2006, presented with infantile spasms at six months of age, which later progressed to recurrent, treatment-resistant seizures. We detected a compound heterozygous genotype in UBA5 in the sisters, a genotype not seen elsewhere in an Icelandic reference set of 30,067 individuals nor in public databases. One of the mutations, c.684G > A, is a paternally inherited exonic splicing mutation, occuring at the last nucleotide of exon 7 of UBA5. The mutation is predicted to disrupt the splice site, resulting in loss-of-function of one allele of UBA5. The second mutation is a maternally inherited missense mutation, p.Ala371Thr, previously reported as pathogenic when in compound heterozygosity with a loss-of-function mutation in UBA5 and is believed to produce a hypomorphic allele. Supportive of this, we have identified three adult Icelanders homozygous for the p.Ala371Thr mutation who show no signs of neurological disease. We describe compound heterozygous mutations in the UBA5 gene in two sisters with early-onset epileptic encephalopathy. To our knowledge, this is the first description of mutations in UBA5 since the initial discovery that pathogenic biallelic

  9. Two sisters with clinical diagnosis of Wiskott-Aldrich Syndrome: Is the condition in the family autosomal recessive?

    Energy Technology Data Exchange (ETDEWEB)

    Kondoh, T.; Hayashi, K.; Matsumoto, T. [Nagasaki Univ. School of Medicine (Japan)] [and others

    1995-10-09

    We report two sisters in a family representing manifestations of Wiskott-Aldrich syndrome (WAS), an X-linked immunodeficiency disorder. An elder sister had suffered from recurrent infections, small thrombocytopenic petechiae, purpura, and eczema for 7 years. The younger sister had the same manifestations as the elder sister`s for a 2-year period, and died of intracranial bleeding at age 2 years. All the laboratory data of the two patients were compatible with WAS, although they were females. Sialophorin analysis with the selective radioactive labeling method of this protein revealed that in the elder sister a 115-KD band that should be specific for sialophorin was reduced in quantity, and instead an additional 135-KD fragment was present as a main band. Polymerase chain reaction (PCR) analysis of the sialophorin gene and single-strand conformation polymorphism (SSCP) analysis of the PCR product demonstrated that there were no detectable size-change nor electrophoretic mobility change in the DNA from both patients. The results indicated that their sialophorin gene structure might be normal. Studies on the mother-daughter transmission of X chromosome using a pERT84-MaeIII polymorphic marker mapped at Xp21 and HPRT gene polymorphism at Xq26 suggested that each sister had inherited a different X chromosome from the mother. Two explanations are plausible for the occurrence of the WAS in our patients: the WAS in the patients is attributable to an autosomal gene mutation which may regulate the sialophorin gene expression through the WAS gene, or, alternatively, the condition in this family is an autosomal recessive disorder separated etiologically from the X-linked WAS. 17 refs., 6 figs., 1 tab.

  10. Annual symposium on Frontiers in Science

    Energy Technology Data Exchange (ETDEWEB)

    Metzger, N.; Fulton, K.R.

    1998-12-31

    This final report summarizes activities conducted for the National Academy of Sciences' Annual Symposium on Frontiers of Science with support from the US Department of Energy for the period July 1, 1993 through May 31, 1998. During the report period, five Frontiers of Science symposia were held at the Arnold and Mabel Beckman Center of the National Academies of Sciences and Engineering. For each Symposium, an organizing committee appointed by the NAS President selected and planned the eight sessions for the Symposium and identified general participants for invitation by the NAS President. These Symposia accomplished their goal of bringing together outstanding younger (age 45 or less) scientists to hear presentations in disciplines outside their own and to discuss exciting advances and opportunities in their fields in a format that encourages, and allows adequate time for, informal one-on-one discussions among participants. Of the 458 younger scientists who participated, over a quarter (124) were women. Participant lists for all symposia (1993--1997) are attached. The scientific participants were leaders in basic research from academic, industrial, and federal laboratories in such disciplines as astronomy, astrophysics, atmospheric science, biochemistry, cell biology, chemistry, computer science, earth sciences, engineering, genetics, material sciences, mathematics, microbiology, neuroscience, physics, and physiology. For each symposia, the 24 speakers and discussants on the program were urged to focus their presentations on current cutting-edge research in their field for a scientifically sophisticated but non-specialist audience, and to provide a sense of the experimental data--what is actually measured and seen in the various fields. They were also asked to address questions such as: What are the major research problems and unique tools in their field? What are the current limitations on advances as well as the frontiers? Speakers were asked to provide a

  11. Isotope hydrology 1983. Proceedings of a symposium

    International Nuclear Information System (INIS)

    1984-01-01

    These proceedings contain the papers and poster presentations from the Symposium on Isotope Hydrology held 12-16 September 1983 in Vienna, Austria. The topics of the sessions were as follows: Thermal water studies, groundwater dating, hydrology of arid and semi-arid areas, field studies with environmental isotopes, precipitation-surface-groundwater relationships, pollution, artificial tracers and sediment transport. Twenty poster presentations in English have been indexed here separately. All other articles from this Proceedings Series are available under ISBN 92-0-040087-6

  12. Proceedings of the 1980 DOE statistical symposium

    International Nuclear Information System (INIS)

    Truett, T.; Margolies, D.; Mensing, R.W.

    1981-04-01

    Separate abstracts were prepared for 8 of the 16 papers presented at the DOE Statistical Symposium in California in October 1980. The topics of those papers not included cover the relative detection efficiency on sets of irradiated fuel elements, estimating failure rates for pumps in nuclear reactors, estimating fragility functions, application of bounded-influence regression, the influence function method applied to energy time series data, reliability problems in power generation systems and uncertainty analysis associated with radioactive waste disposal. The other 8 papers have previously been added to the data base

  13. Symposium on irradiation for national development. Proceedings

    International Nuclear Information System (INIS)

    Adesanmi, C.A.; Ogbadu, G.H.

    1998-01-01

    This document is the full proceedings of the symposium on irradiation for national development held at SHESTCO in 1996. It contains the full texts of a forward, opening and special remarks, welcome and keynote addresses and abstracts and texts of 23 technical papers. The subjects covered included regulations, codes of practice, irradiation technology in food, agriculture and industry, radiation protection and dosimetry. The questions, answers and comments in the discussion sessions are also included. Additionally, the abstracts of 8 other papers are included. We wish to thank the Coordinator of SHESTCO for making available this proceedings

  14. Symposium on isotope production and applications

    International Nuclear Information System (INIS)

    1981-01-01

    This report contains the papers delivered at the symposium on isotope production and applications, held at Pelindaba, Pretoria, South Africa. The following topics were discussed: facilities for the production of radioisotopes at Pelindaba; the role of the chemist in the development and production of radioisotopic preparations; quality control of radioisotopic products; applications of radioisotopes in medicine; concepts and current status of nuclear imaging; industrial and research applications of radioisotopic tracers and radioisotopic radiation sources; radiation processing using intense radioisotopic radiation sources; a review of current and future radioisotope production activities at the Council for Scientific and Industrial Research

  15. International Symposium on Complex Computing-Networks

    CERN Document Server

    Sevgi, L; CCN2005; Complex computing networks: Brain-like and wave-oriented electrodynamic algorithms

    2006-01-01

    This book uniquely combines new advances in the electromagnetic and the circuits&systems theory. It integrates both fields regarding computational aspects of common interest. Emphasized subjects are those methods which mimic brain-like and electrodynamic behaviour; among these are cellular neural networks, chaos and chaotic dynamics, attractor-based computation and stream ciphers. The book contains carefully selected contributions from the Symposium CCN2005. Pictures from the bestowal of Honorary Doctorate degrees to Leon O. Chua and Leopold B. Felsen are included.

  16. Proceedings of symposium on technology in laboratories

    International Nuclear Information System (INIS)

    2008-03-01

    The Symposium on Technology in Laboratories was held on both 10th and 11th March 2008 at Ceratopia Toki in Toki city, Gifu Prefecture, Japan, which hosted by the National Institute for Fusion Science (NIFS). 287 people participated and 97 papers were presented from many universities, national laboratories, technical colleges, and some industries in Japan. Technical experience and new techniques were reported and discussed in four fields: technology of fabrication and cryogenics', 'device technology', 'diagnostic and control system', and 'computer and processing'. The 37 of the presented papers are indexed individually. (J.P.N.)

  17. Proceedings: Ninth international ash use symposium

    International Nuclear Information System (INIS)

    1991-01-01

    The objective of the 1991 International Coal Ash Use Symposium, the ninth in a series since 1967, is to publicize innovations in coal ash technology. The three-volume publication contains 80 papers, presented at seventeen sessions during the January 1991 event. Volume 1 contains papers related to concrete and related products like cellular concrete, and aggregates. This volume before (Volume 2) covers the growing market in waste stabilization/solidification and aquatic uses. Volume 3 brings together papers on a variety of high-volume uses, and R ampersand D projects. Individual projects are processed separately for the databases

  18. 2015 Association for Women in Mathematics Symposium

    CERN Document Server

    Lauter, Kristin; Chambers, Erin; Flournoy, Nancy; Grigsby, Julia; Martin, Carla; Ryan, Kathleen; Trivisa, Konstantina

    2016-01-01

    Presenting the latest findings in topics from across the mathematical spectrum, this volume includes results in pure mathematics along with a range of new advances and novel applications to other fields such as probability, statistics, biology, and computer science. All contributions feature authors who attended the Association for Women in Mathematics Research Symposium in 2015: this conference, the third in a series of biennial conferences organized by the Association, attracted over 330 participants and showcased the research of women mathematicians from academia, industry, and government.

  19. 21st International Symposium on Spin Physics

    CERN Document Server

    Ma, Bo-Qiang; SPIN 2014; SPIN2014

    2016-01-01

    This special volume collected important papers written by leading experts, highlighting the latest research findings in various topics of spin phenomena in particle and nuclear physics. The contents are originated from the plenary talks at the latest symposium of the Spin Physics series (SPIN2014) which was held in Beijing, China, October 20-24, 2014.The volume also comprises a special collection of contributions in memory of the late Professor Michel Borghini, an outstanding physicist well remembered for his great contributions to the progress of high energy spin physics.

  20. International Symposium on Computing and Network Sustainability

    CERN Document Server

    Akashe, Shyam

    2017-01-01

    The book is compilation of technical papers presented at International Research Symposium on Computing and Network Sustainability (IRSCNS 2016) held in Goa, India on 1st and 2nd July 2016. The areas covered in the book are sustainable computing and security, sustainable systems and technologies, sustainable methodologies and applications, sustainable networks applications and solutions, user-centered services and systems and mobile data management. The novel and recent technologies presented in the book are going to be helpful for researchers and industries in their advanced works.

  1. Laser-induced damage in optical materials: sixteenth ASTM symposium.

    Science.gov (United States)

    Bennett, H E; Guenther, A H; Milam, D; Newnam, B E

    1987-03-01

    The Sixteenth Annual Symposium on Optical Materials for High Power Lasers (Boulder Damage Symposium) was held at the National Bureau of Standards in Boulder, CO, 15-17 Oct. 1984. The Symposium was held under the auspices of ASTM Committee F-1, Subcommittee on Laser Standards, with the joint sponsorship of NBS, the Defense Advanced Research Project Agency, the Department of Energy, the Office of Naval Research, and the Air Force Office of Scientific Research. Approximately 180 scientists attended the Symposium, including representatives from England, France, The Netherlands, Scotland, and West Germany. The Symposium was divided into sessions concerning Materials and Measurements, Mirrors and Surfaces, Thin Films, and Fundamental Mechanisms. As in previous years, the emphasis of the papers presented at the Symposium was directed toward new frontiers and new developments. Particular emphasis was given to materials for high-power apparatus. The wavelength range of prime interest was from 10.6,microm to the UV region. Highlights included surface characterization, thin-film-substrate boundaries, and advances in fundamental laser-matter threshold interactions and mechanisms. Harold E. Bennett of the U.S. Naval Weapons Center, Arthur H. Guenther of the U.S. Air Force Weapons Laboratory, David Milam of the Lawrence Livermore National Laboratory, and Brian E. Newnam of the Los Alamos National Laboratory were cochairmen of the Symposium.

  2. Three Sisters Mountain Village development transformation of old coal mine properties into modern day use

    Energy Technology Data Exchange (ETDEWEB)

    Fox, B. [Golder Paste Technology Ltd., Sudbury, ON (Canada)

    2006-07-01

    This paper discussed the development of the Three Sisters Mountain Village, located close to Canmore, Alberta. The paper provided the history and background of the mining and development of the site. It discussed underground mining methodology and planned housing and industrial development. The village included plans for 10,000 residential homes, 2 golf courses, a wellness centre, a school, commercial buildings and wildlife corridors. Environmental concerns were also addressed, as Canmore contains a series of natural wildlife corridors, which act as migration and travelling routes for elk and deer as well as cougars, grizzly bears, and other animals. These routes are essential for the survival of the different herds and animal species. The development progress strategy was discussed. The Three Sisters Mountain Village Development commissioned Golder Associates Ltd. to study and address the environmental concerns of the stakeholders regarding the migrating routes of wildlife. Mining works mitigation, including mapping of the constraint zones, knowledge of subsidence issues and the effects of subsidence on structural stress and the ability to analysis field data to predict potential problems was also presented along with a methodology for mitigation and choice of backfill material to be used to fill the mine workings. The advantages of using concrete paste backfill were also identified.

  3. Three Sisters Mountain Village development transformation of old coal mine properties into modern day use

    International Nuclear Information System (INIS)

    Fox, B.

    2006-01-01

    This paper discussed the development of the Three Sisters Mountain Village, located close to Canmore, Alberta. The paper provided the history and background of the mining and development of the site. It discussed underground mining methodology and planned housing and industrial development. The village included plans for 10,000 residential homes, 2 golf courses, a wellness centre, a school, commercial buildings and wildlife corridors. Environmental concerns were also addressed, as Canmore contains a series of natural wildlife corridors, which act as migration and travelling routes for elk and deer as well as cougars, grizzly bears, and other animals. These routes are essential for the survival of the different herds and animal species. The development progress strategy was discussed. The Three Sisters Mountain Village Development commissioned Golder Associates Ltd. to study and address the environmental concerns of the stakeholders regarding the migrating routes of wildlife. Mining works mitigation, including mapping of the constraint zones, knowledge of subsidence issues and the effects of subsidence on structural stress and the ability to analysis field data to predict potential problems was also presented along with a methodology for mitigation and choice of backfill material to be used to fill the mine workings. The advantages of using concrete paste backfill were also identified

  4. Sisters in hereditary breast and ovarian cancer families: communal coping, social integration, and psychological well-being.

    Science.gov (United States)

    Koehly, Laura M; Peters, June A; Kuhn, Natalia; Hoskins, Lindsey; Letocha, Anne; Kenen, Regina; Loud, Jennifer; Greene, Mark H

    2008-08-01

    We investigated the association between psychological distress and indices of social integration and communal coping among sisters from hereditary breast and ovarian cancer (HBOC) families. Sixty-five sisters from 31 HBOC families completed the Brief Symptom Inventory-18 and the Colored Eco-Genetic Relationship Map, which identified members of participants' social support networks. Hierarchical linear models were used for all analyses to account for the clustering of sisters within families. Intra-family correlation coefficients suggested that sisters shared perceptions of breast cancer risk and worry, but not ovarian cancer risk and worry. Further, sisters demonstrated shared levels of anxiety and somatization, but not depressive symptoms. Communal coping indices quantifying shared support resources were negatively related to anxiety and somatization. The number of persons with whom cancer risk information was shared exhibited a positive trend with somatization. Social integration, as measured by the size of participants' emotional support network, was negatively associated with anxiety. Lower depression scores were observed among participants with more persons playing multiple support roles and fewer persons providing tangible assistance. Understanding how support relationships impact well-being among persons adjusting to HBOC risk, and the particular role of family in that process, will facilitate developing appropriate management approaches to help cancer-prone families adjust to their cancer risk.

  5. Proceedings of the sixteenth biennial low-rank fuels symposium

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    Low-rank coals represent a major energy resource for the world. The Low-Rank Fuels Symposium, building on the traditions established by the Lignite Symposium, focuses on the key opportunities for this resource. This conference offers a forum for leaders from industry, government, and academia to gather to share current information on the opportunities represented by low-rank coals. In the United States and throughout the world, the utility industry is the primary user of low-rank coals. As such, current experiences and future opportunities for new technologies in this industry were the primary focuses of the symposium.

  6. 2010 International lectures and 2011 Symposium at NTUT

    OpenAIRE

    Suto, Masahiko

    2012-01-01

    National University Corporation of Tsukuba University of Technology (NTUT) hostedInternational Symposium on “Higher Education for People with Hearing or Visual Impairments.”We discussed issues regarding “Higher Education,” “Employment after Graduation,” and“Entrance to Higher Education for Disabled People.”This year we entitled the symposium “Overseas Education Support for Hearing and VisuallyImpaired Students in Korea,” as the title of the 2010 symposium was “Experience of AcceptingOverseas ...

  7. The ILL millennium symposium and European user meeting

    International Nuclear Information System (INIS)

    Carlile, C.J.; Frick, B.; Radaelli, P.G.; Alba-Simionesco, C.; Chauty, A.; Niss, K.; Casas, F.; Sokolov, A.; Lequeux, F.; Montes, H.; Harrison, A.; Schurtenberger, P.; Dubbers, D.; Frank, A.; Gudel, H.U.; Wagner, R.; Vettier, C.; Gahler, R.; Protassov, K.; Geltenbort, P.; Plonka, C.; Simpson, G.; Pinston, J.A.; Genevey, J.; Urban, W.; Scherillo, A.; Orlandi, R.; Smith, A.G.; Mana, G.; Abele, H.; Van der Grinten, M.; Steuwer, A.; Klotz, S.; Hamel, G.; Strassle, C.Th.; Kervananois, N.; Koza, M.M.; Nishiyama, Y.; Langan, P.; Wada, M.; Sugiyama, J.; Chanzy, H.; Gunter, M.M.; Lerch, M.; Boysen, H.; Korte, C.; Suard, E.; Blanco, J.A.; Fernandez-Rodriguez, J.; Brown, P.J.; Stunault, A.; Katsumata, K.; Lovesey, S.W.; Iga, F.; Michimura, S.; Kremer, R.K.; Banks, M.; Capogna, L.; Enderle, M.; Gibson, B.J.; McIntyre, G.J.; Ouladdiaf, B.; Pujol, S.; Raggazzoni, J.L.; Rheinstadter, M.; Schefer, J.; Boehm, M.; Roessli, B.; Wills, A.S.; Ouladdiaf, B.; Lelievre-Berna, E.; Goff, J.P.; Toader, A.M.; Skoulatos, M.; Enderle, M.; Stewart, J.R.; Murani, A.; Roger, M.; Shannon, N.; Kaul, E.E.; Geibel, C.; Simonet, V.; Lhotel, E.; Paulsen, C.; Ressouche, E.; Staub, U.; Amato, A.; Baines, C.; Petrakovskii, G.A.; Bramwell, S.; Fukuhara, N.; Ebert, J.; Lindner, D.; Dauvergne, M.T.; Hartlein, M.; Timmins, P.; Conti, E.; Svergun, D.; Budayova-Spano, M.; Bonnete, F.; El Hajji, M.; Blakeley, M.P.; Meilleur, F.; Castro, B.; Gabel, F.; Ferrand, M.; Chenal, A.; Forge, V.; Fragneto, G.; Haertlein, M.; Gillet, D.; Haertlein, M.

    2006-01-01

    Five years ago the ILL (Institute Laue-Langevin) convened the first Millennium symposium in order to launch an ambitious modernization program of instruments and infrastructure known as the ILL Millennium Program. After 5 years of activity we have decided to run a second such symposium. The scientific program of this Millennium Symposium will address the following points: -) instrumental and scientific achievements made possible by the Millennium Program, -) trends in science and engineering and the implications for the ILL, -) scenarios for future instrumentation and user support facilities, and -) the scientific priorities of the user community. This document gathers the abstracts of 63 contributions and 73 posters

  8. Proceedings of the first internet symposium on nuclear data

    Energy Technology Data Exchange (ETDEWEB)

    Fukahori, Tokio; Iwamoto, Osamu; Nakagawa, Tsuneo [eds.] [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-03-01

    The First Internet Symposium on Nuclear Data (ISND-1) was held on the WWW home page of Nuclear Data Center at Tokai Research Establishment, Japan Atomic Energy Research Institute (JAERI), from April 8 to June 15, 1996. This symposium was organized by Japanese Nuclear Data Committee and Nuclear Data Center, JAERI and was the first trial to use `Internet` for the symposium in a nuclear data field. In ISND-1, presented were 25 papers on various topics of nuclear data. Those presented papers are compiled in this proceedings as well as brief description about management of ISND-1. (author)

  9. Nagasaki symposium on Chernobyl: Update and future. Proceedings

    International Nuclear Information System (INIS)

    Nagataki, Shigenobu

    1994-01-01

    This publication contains valuable, up-to-date scientific information on the health effects of the Chernobyl accident, obtained from almost all the leading international and national organizations. The purpose of the Nagasaki symposium on Chernobyl was to present and discuss the available data from all over the world independent of psychological, social, economic, and political bias, and thus to make conclusions that would further medical science. To this end, the symposium consisted of two sessions, 'Chernobyl update' and 'Chernobyl in the future'. Along with the proceedings of these two sessions, the proceedings of the Japan-NIS Chernobyl thyroid symposium, held in December 1993 are included in this book. (orig.)

  10. Proceedings of the sixteenth biennial low-rank fuels symposium

    International Nuclear Information System (INIS)

    1991-01-01

    Low-rank coals represent a major energy resource for the world. The Low-Rank Fuels Symposium, building on the traditions established by the Lignite Symposium, focuses on the key opportunities for this resource. This conference offers a forum for leaders from industry, government, and academia to gather to share current information on the opportunities represented by low-rank coals. In the United States and throughout the world, the utility industry is the primary user of low-rank coals. As such, current experiences and future opportunities for new technologies in this industry were the primary focuses of the symposium

  11. The ILL millennium symposium and European user meeting

    Energy Technology Data Exchange (ETDEWEB)

    Carlile, C.J.; Frick, B.; Radaelli, P.G.; Alba-Simionesco, C.; Chauty, A.; Niss, K.; Casas, F.; Sokolov, A.; Lequeux, F.; Montes, H.; Harrison, A.; Schurtenberger, P.; Dubbers, D.; Frank, A.; Gudel, H.U.; Wagner, R.; Vettier, C.; Gahler, R.; Protassov, K.; Geltenbort, P.; Plonka, C.; Simpson, G.; Pinston, J.A.; Genevey, J.; Urban, W.; Scherillo, A.; Orlandi, R.; Smith, A.G.; Mana, G.; Abele, H.; Van der Grinten, M.; Steuwer, A.; Klotz, S.; Hamel, G.; Strassle, C.Th.; Kervananois, N.; Koza, M.M.; Nishiyama, Y.; Langan, P.; Wada, M.; Sugiyama, J.; Chanzy, H.; Gunter, M.M.; Lerch, M.; Boysen, H.; Korte, C.; Suard, E.; Blanco, J.A.; Fernandez-Rodriguez, J.; Brown, P.J.; Stunault, A.; Katsumata, K.; Lovesey, S.W.; Iga, F.; Michimura, S.; Kremer, R.K.; Banks, M.; Capogna, L.; Enderle, M.; Gibson, B.J.; McIntyre, G.J.; Ouladdiaf, B.; Pujol, S.; Raggazzoni, J.L.; Rheinstadter, M.; Schefer, J.; Boehm, M.; Roessli, B.; Wills, A.S.; Ouladdiaf, B.; Lelievre-Berna, E.; Goff, J.P.; Toader, A.M.; Skoulatos, M.; Enderle, M.; Stewart, J.R.; Murani, A.; Roger, M.; Shannon, N.; Kaul, E.E.; Geibel, C.; Simonet, V.; Lhotel, E.; Paulsen, C.; Ressouche, E.; Staub, U.; Amato, A.; Baines, C.; Petrakovskii, G.A.; Bramwell, S.; Fukuhara, N.; Ebert, J.; Lindner, D.; Dauvergne, M.T.; Hartlein, M.; Timmins, P.; Conti, E.; Svergun, D.; Budayova-Spano, M.; Bonnete, F.; El Hajji, M.; Blakeley, M.P.; Meilleur, F.; Castro, B.; Gabel, F.; Ferrand, M.; Chenal, A.; Forge, V.; Fragneto, G.; Haertlein, M.; Gillet, D.; Haertlein, M

    2006-07-01

    Five years ago the ILL (Institute Laue-Langevin) convened the first Millennium symposium in order to launch an ambitious modernization program of instruments and infrastructure known as the ILL Millennium Program. After 5 years of activity we have decided to run a second such symposium. The scientific program of this Millennium Symposium will address the following points: -) instrumental and scientific achievements made possible by the Millennium Program, -) trends in science and engineering and the implications for the ILL, -) scenarios for future instrumentation and user support facilities, and -) the scientific priorities of the user community. This document gathers the abstracts of 63 contributions and 73 posters.

  12. Proceedings of the 3rd Symposium on Engineering Sciences

    International Nuclear Information System (INIS)

    Ahmed, J.; Rizvi, S.Z.H.; Ahmad, R.; Saleem, M.

    2010-01-01

    The 3rd symposium on engineering sciences was held from March 10-12, 2010 in Lahore, Pakistan. More than twenty academic institutions and six industries participated in this conference. The foreign and Pakistani experts delivered their keynotes talk, contributor lectures and poster presentation on the conference topics. In three days of the symposium, Fifty four papers presented on different topics of Engineering Sciences including chemical engineering, energy engineering, metallurgy engineering, material engineering and electrical engineering. This symposium provided an ideal opportunity for exchange of information amongst scientists, engineers and researchers from all over Pakistan and other countries of the world. (A.B)

  13. IEEE International Symposium on Biomedical Imaging.

    Science.gov (United States)

    2017-01-01

    The IEEE International Symposium on Biomedical Imaging (ISBI) is a scientific conference dedicated to mathematical, algorithmic, and computational aspects of biological and biomedical imaging, across all scales of observation. It fosters knowledge transfer among different imaging communities and contributes to an integrative approach to biomedical imaging. ISBI is a joint initiative from the IEEE Signal Processing Society (SPS) and the IEEE Engineering in Medicine and Biology Society (EMBS). The 2018 meeting will include tutorials, and a scientific program composed of plenary talks, invited special sessions, challenges, as well as oral and poster presentations of peer-reviewed papers. High-quality papers are requested containing original contributions to the topics of interest including image formation and reconstruction, computational and statistical image processing and analysis, dynamic imaging, visualization, image quality assessment, and physical, biological, and statistical modeling. Accepted 4-page regular papers will be published in the symposium proceedings published by IEEE and included in IEEE Xplore. To encourage attendance by a broader audience of imaging scientists and offer additional presentation opportunities, ISBI 2018 will continue to have a second track featuring posters selected from 1-page abstract submissions without subsequent archival publication.

  14. Third international symposium on alcohol fuels technology

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-04-01

    At the opening of the Symposium, Dr. Sharrah, Senior Vice President of Continental Oil Company, addressed the attendees, and his remarks are included in this volume. The Symposium was concluded by workshops which addressed specific topics. The topical titles are as follows: alcohol uses; production; environment and safety; and socio-economic. The workshops reflected a growing confidence among the attendees that the alcohols from coal, remote natural gas and biomass do offer alternatives to petroleum fuels. Further, they may, in the long run, prove to be equal or superior to the petroleum fuels when the aspects of performance, environment, health and safety are combined with the renewable aspect of the biomass derived alcohols. Although considerable activity in the production and use of alcohols is now appearing in many parts of the world, the absence of strong, broad scale assessment and support for these fuels by the United States Federal Government was a noted point of concern by the attendees. The environmental consequence of using alcohols continues to be more benign in general than the petroleum based fuels. The exception is the family of aldehydes. Although the aldehydes are easily suppressed by catalysts, it is important to understand their production in the combustion process. Progress is being made in this regard. Of course, the goal is to burn the alcohols so cleanly that catalytic equipment can be eliminated. Separate abstracts are prepared for the Energy Data Base for individual presentations.

  15. 29th International Symposium on Superconductivity

    International Nuclear Information System (INIS)

    2017-01-01

    Preface It is our pleasure to report that the Proceedings of the 29 th International Symposium on Superconductivity (ISS2016) held at Tokyo International Forum, Japan, December 13–15, 2016, are now published in Journal of Physics: Conference Series (JPCS). ISS2016, organized by the National Institute of Advanced Industrial Science and Technology (AIST), was aimed to gather many scientists, engineers, academic students, corporate executives and other participants from all over the world, and to facilitate fruitful discussions to promote superconductivity technologies. 427 scientists and engineers from 15 countries participated in ISS2016, and the symposium was successfully held. Total of 321 papers were presented, which includes 6 plenary lectures, 38 invited talks, 67 contributed oral presentations and 210 poster presentations. The papers published in JPCS were categorized into the following four fields; (a) Physics and Chemistry, (b) Wires and Bulk, (c) Electronic Devices, (d) Large Scale System Applications, and arranged in such a way that oral presentations come first, followed by poster presentations in relevant topics. To ensure the high publication standard mandated by JPCS, every paper was peer reviewed by a reviewer with expertise, and in some cases by two reviewers before it was accepted for publication. As editors of the Proceedings, we would like to express our sincere appreciation to all the reviewers involved in the evaluation of the papers for their invaluable contribution. Our special thanks go also to session chairs who recommended appropriate reviewers. List of Editors and Committees are also available in this PDF. (paper)

  16. XI Symposium on Probability and Stochastic Processes

    CERN Document Server

    Pardo, Juan; Rivero, Víctor; Bravo, Gerónimo

    2015-01-01

    This volume features lecture notes and a collection of contributed articles from the XI Symposium on Probability and Stochastic Processes, held at CIMAT Mexico in September 2013. Since the symposium was part of the activities organized in Mexico to celebrate the International Year of Statistics, the program included topics from the interface between statistics and stochastic processes. The book starts with notes from the mini-course given by Louigi Addario-Berry with an accessible description of some features of the multiplicative coalescent and its connection with random graphs and minimum spanning trees. It includes a number of exercises and a section on unanswered questions. Further contributions provide the reader with a broad perspective on the state-of-the art of active areas of research. Contributions by: Louigi Addario-Berry Octavio Arizmendi Fabrice Baudoin Jochen Blath Loïc Chaumont J. Armando Domínguez-Molina Bjarki Eldon Shui Feng Tulio Gaxiola Adrián González Casanova Evgueni Gordienko Daniel...

  17. Marine pollution. Proceedings of an international symposium

    International Nuclear Information System (INIS)

    1999-07-01

    The marine environment - understanding and protecting for the future were at the forefront of the International Symposium on Marine Pollution convened in Monaco from 5 to 9 October 1998, as one of the major events of the UN International Year of Oceans. Over 400 international experts from 61 Member States and 8 international organizations delivered 114 oral presentations in plenary and parallel sessions and made 215 poster presentations. New achievements were reported in identifying the sources of pollution, on the behaviour and fate of contaminants in seawater, biota and sediments, on the use of radioactive and non-radioactive tracers for the studies of transport and circulation processes in the world's oceans and seas, on studies of radioactive waste dumping sites and nuclear weapons test sites, on local, regional and global computer modelling of the transport of contaminants and on many other topics in marine pollution. New developments in high sensitivity analytical measurements of contaminants with emphasis on nuclear and isotopic methods were also presented. Information on global and regional marine pollution studies programmes was also given and participants had the chance to interacts with leading experts in the field and ro discuss future trends in marine pollution studies. This TECDOC contains some of the papers submitted on issues falling within the thematic scope od the symposium which were presented in oral and poster presentations

  18. Army symposium: Electrical energy engineering today; Wehrtechnisches Symposium: Moderne elektrische Energietechnik

    Energy Technology Data Exchange (ETDEWEB)

    Busse, H. (ed.) [Bundesakademie fuer Wehrverwaltung und Wehrtechnik, Mannheim (Germany). Fachgebiet Elektrotechnik und Elektroenergiewesen

    2000-05-01

    This symposium was held in Mannheim on May 20/21, 2000. All aspects of energy engineering were discussed, including electrochemical energy sources like accumulator batteries and fuel cells. The proceedings volume contains 26 papers which reflect the state of the art and current trends in electrical energy engineering in the German army. [German] Das Wehrtechnische Symposium 'Moderne elektrische Energietechnik' wurde von der Lehrabteilung Wehrtechnik der Bundesakademie fuer Wehrverwaltung und Wehrtechnik in Mannheim in der Zeit vom 20.05.-21.05.2000 durchgefuehrt. Das Programm enthaelt die aktuellen Themen der elektrischen Energietechnik. Die elektroschemischen Energiequellen (Batterien und Brennstoffzellen) wurden in das Programm integriert. Dadurch konnte das gesamte Spektrum der Energietechnik vielschichtig dargestellt und in der Diskussion unter z.T. sehr verschiedenen Gesichtspunkten beleuchtet werden. Die im vorliegenden Tagungsband abgedruckten 26 Skripte wurden weder gekuerzt noch ergaenzt. Sie zeigen insgesamt den aktuellen Stand und die erfolgversprechenden Entwicklungstendenzen der elektrischen Energietechnik in der Bundeswehr auf. (orig.)

  19. NATO Symposium entitled "Symposium on the Study of Motion Perception : Recent Developments and Applications"

    CERN Document Server

    Wagenaar, Willem; Leibowitz, Herschel

    1982-01-01

    From August 24-29, 1980 the international "Symposium on the Study of Motion Perception; Recent Developments and Applications", sponsored by NATO and organized by the editors of this book, was held in Veldhoven, the Netherlands. The meeting was attended by about eighty scholars, including psychologists, neurologists, physicists and other scientists, from fourteen different countries. During the symposium some fifty research papers were presented and a series of tutorial review papers were read and discussed. The research presentations have been published in a special issue of the international journal of psychonomics "Acta Psychologica" (Vol. 48, 1981). The present book is a compilation of the tutorial papers. The tutorials were arranged around early versions of the chapters now appearing in this book. The long discussions at the Veldhoven tutorial sessions resulted in extensive revisions of the texts prior to this publication. Unfortunately this led to a delay in publication, but we feel that this was justifi...

  20. 4. International Symposium and Exhibition on Environmental Contamination in Central and Eastern Europe. Symposium Program

    International Nuclear Information System (INIS)

    1998-01-01

    The Fourth International Symposium and Exhibition on Environmental Contamination in Central and Eastern Europe was part of an on-going series of symposia which focus on the environmental problems of Central and Eastern Europe. The presentations concerned radiological contamination, hazardous waste management, environmental monitoring, modeling and computer applications for environmental studies, site remediation. Many works presented human health effects of environmental pollution by heavy metals, radionuclides and other xenobiotics