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Sample records for sydnones

  1. Environmentally benign synthesis of sydnone containing 1,3,4 ...

    Indian Academy of Sciences (India)

    TECS

    lop benign synthetic methods for sydnone deriva- tives,. 9 we report here a new series of sydnone containing 1,3,4-thiadiazines by microwave irradia- tion under solvent-free conditions. 2. Experimental. 2.1 General remarks. Melting points were determined by open capillary method and are uncorrected. All compounds were.

  2. Environmentally benign synthesis of sydnone containing 1,3,4 ...

    Indian Academy of Sciences (India)

    TECS

    Introduction. The application of microwave as an energy source for chemical reactions and processes has been extensively studied during recent years. 1. The combination of sol- ... on Bruker AC 300 F (300 MHz) NMR spectrometer using DMSO-d6 as a ... Jeol JMS-D 300 Mass spectrometer or API 3000. LCMS instrument ...

  3. Regioselective reaction: synthesis, characterization and pharmacological activity of some new Mannich and Schiff bases containing sydnone.

    Science.gov (United States)

    Nithinchandra; Kalluraya, B; Aamir, S; Shabaraya, A R

    2012-08-01

    A novel series of 1-substituted aminomethyl-3-[1-(4-isobutylphenyl)ethyl]-4-(3-aryl-4-sydnonylidene) amino-1,2,4-triazol-5-thiones (9), was prepared from the 3-[1-(4-isobutylphenyl)ethyl]-4-(3-aryl-4-sydnonylidene) amino 5-mercapto-1,2,4-triazoles (8) by aminomethylation with formaldehyde and secondary amine. The structures of Schiff bases (8) and Mannich bases (9) were characterized on the basis of IR, NMR, mass spectra1 data and elemental analysis. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activities. Mannich bases (9) carrying piperidine and morpholine residues showed promising anti-inflammatory and analgesic activity. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  4. Mesoionic Compounds

    Indian Academy of Sciences (India)

    Sydnone, the representative mesoionic compound has been extensively studied because of its unusual structure, chemi- cal properties and synthetic utility. Sydnone is used as a versatile synthon in heterocyclic synthesis. This article gives a brief account of the comparative studies of the structural features of mesoionic ...

  5. SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL-1, 3, 4-THIADIAZINO (6, 5-B INDOLES

    Directory of Open Access Journals (Sweden)

    Hemant Panwar

    2011-12-01

    Full Text Available In the present study, a series of 2-(4´-Substitutedanilinosydnon-3´-yl-1, 3, 4-thiadiazino (6, 5-b indoles 7a-j have been synthesized. All the synthesized compounds have been characterized by elemental and spectral (I R, 1H- NMR and Mass spectrometric analysis. Furthermore, above mentioned compounds were evaluated for their antibacterial and antifungal activities against selected panel of pathogenic strains. Ampicillin trihydrate, ofloxacin and fluconazole, griseofulvin were used as standard drugs for antibacterial and anifungal activity respectively. Compound 7j was found the most potent one with lesser toxicity in the prepared indole derivatives.

  6. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    3-[4-(Azidocarbonyl)]phenylsydnone (2) obtained from 3-(4-hydrazinocarbonyl) phenylsydnone (1) on Curtius rearrangement with alcohols, water and amines afforded the corresponding carbamates (3a-h), 4,4'-(sydnone-3-yl) diphenyl urea (4) and 4-(heterocyclyl)phenyl ureas (5a-l). Compounds (5a-l) on one-pot ring ...

  7. Synthesis and studies of bissydnone sulfonamides based on 4,4’-diaminodiphenyl methane

    Directory of Open Access Journals (Sweden)

    Shahrukh T. Asundaria

    2009-12-01

    Full Text Available 3,3’-(4,4’-Diphenylbissydnonyl methane (5 was synthesized and subjected to chlorosulfonation followed by amination resulted in to formation of 3,3’-(methylenedi-1,4-phenylenebis[4-{(4-substituted-aminosulfonyl} sydnone (7a-j. The structure of the newly synthesized compounds was checked by spectral data and purity of the compounds was checked by elemental analysis as well as thin layer chromatography. Some compounds showed excellent activity against gram positive and gram negative bacterial strain.

  8. Synthesis and studies of bissydnone sulfonamides based on 4,4’-diaminodiphenyl methane

    Directory of Open Access Journals (Sweden)

    Shahrukh T. Asundaria

    2010-01-01

    Full Text Available 3,3’-(4,4’-Diphenylbissydnonyl methane (5 was synthesized and subjected to chlorosulfonation followed by amination resulted in to formation of 3,3’-(methylenedi-1,4-phenylenebis[4-{(4-substituted-aminosulfonyl} sydnone (7a-j. The structure of the newly synthesized compounds was checked by spectral data and purity of the compounds was checked by elemental analysis as well as thin layer chromatography. Some compounds showed excellent activity against gram positive and gram negative bacterial strain.