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Sample records for sv wave speed

  1. Reflection of quasi-P and quasi-SV waves at the free and rigid ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    waves reflected on free and rigid boundaries due to incident qP and qSV waves are also obtained and presented graphically. Keywords. Reflection of waves; quasi-P waves; quasi-SV waves; quasi-SH waves; fibre-reinforced media; reflection coefficients. 1. Introduction. Fibre-reinforced composite materials have become ...

  2. Reflection of P and SV waves from free surface of an elastic solid ...

    Indian Academy of Sciences (India)

    The governing equations for generalized thermodiffusion in an elastic solid are solved. There exists three kinds of dilatational waves and a Shear Vertical (SV) wave in a two-dimensional model of the solid. The reflection phenomena of P and SV waves from free surface of an elastic solid with thermodiffusion is considered.

  3. Reflection of quasi-P and quasi-SV waves at the free and rigid ...

    Indian Academy of Sciences (India)

    The propagation of plane waves in fibre-reinforced media is discussed. The expressions of phase velocities of quasi-P (qP) and quasi-SV (qSV) waves propagating in plane symmetry are obtained in terms of propagation vectors. We have established a relation from which the displacement vector can be obtained in terms of ...

  4. Reflection of P and SV waves at the free surface of a monoclinic ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 111; Issue 4. Reflection of and SV waves at the free surface of a monoclinic elastic half- ... the variation of the reflection coefficients with the angle of incidence. The present analysis corrects some fundamental errors appearing in recent papers on the subject.

  5. Reflection of P and SV waves from free surface of an elastic solid ...

    Indian Academy of Sciences (India)

    The reflection phenomena of P and SV waves from free surface of an elastic solid with thermodiffusion is considered. The boundary conditions are solved to obtain a system of four non- homogeneous equations for reflection coefficients. These reflection coefficients are found to depend upon the angle of incidence of P and ...

  6. The adaptation of limb kinematics to increasing walking speeds in freely moving mice 129/Sv and C57BL/6.

    Science.gov (United States)

    Serradj, Nadjet; Jamon, Marc

    2009-07-19

    The kinematics of locomotion was analyzed in two strains of great importance for the creation of mutated mice (C56BL/6 and 129/Sv). Different behavioral situations were used to trigger sequences of movement covering the whole range of velocities in the mice, and the variations of kinematic parameters were analyzed in relation with velocity. Both stride frequency and stride length contributed to the moving speed, but stride frequency was found to be the main contributor to the speed increase. A trot-gallop transition was detected at speed about 70 cm/s, in relation with a sharp shift in limb coordination. The results of this study were consistent with pieces of information previously published concerning the gait analyses of other strains, and provided an integrative view of the basic motor pattern of mice. On the other hand some qualitative differences were found in the movement characteristics of the two strains. The stride frequency showed a higher contribution to speed in 129/Sv than in C57BL/6. In addition, 129/Sv showed a phase shift in the forelimb and hindlimb, and a different position of the foot during the stance time that revealed a different gait and body position during walking. Overall, 129/Sv moved at a slower speed than C57BL/6 in any behavioral situation. This difference was related to a basal lower level of motor activity. The possibility that an alteration in the dopamine circuit was responsible for the different movement pattern in 129/Sv is discussed.

  7. Reflection of P and SV waves at the free surface of a monoclinic ...

    Indian Academy of Sciences (India)

    R.Narasimhan(krishtel emaging)1461 1996 Oct 15 13:05:22

    d2/d3 = V/(ρc2 − U)=(ρc2 − Z)/V. (12). Therefore, ρc2 satisfies the quadratic equation ρ2c4 − (U + Z)ρc2 + (UZ − V 2)=0,. (13a) with solutions. 2ρc2(p2,p3)=(U + Z) ± [(U − Z)2 + 4V 2]1/2. (13b). The upper sign in equation (13b) is for qP waves and the lower sign is for qSV waves. Eliminating ρc2 from the two equations in (12),.

  8. Numerical Study on Dynamic Response of a Horizontal Layered-Structure Rock Slope under a Normally Incident Sv Wave

    Directory of Open Access Journals (Sweden)

    Zhifa Zhan

    2017-07-01

    Full Text Available Several post-earthquake investigations have indicated that the slope structure plays a leading role in the stability of rock slopes under dynamic loads. In this paper, the dynamic response of a horizontal layered-structure rock slope under harmonic Sv wave is studied by making use of the Fast Lagrangian Analysis of Continua method (FLAC. The suitability of FLAC for studying wave transmission across rock joints is validated through comparison with analytical solutions. After parametric studies on Sv wave transmission across the horizontal layered-structure rock slope, it is found that the acceleration amplification coefficient η, which is defined as the ratio of the acceleration at the monitoring point to the value at the toe, wavily increases with an increase of the height along the slope surface. Meanwhile, the fluctuation weakens with normalized joint stiffness K increasing and enhances with normalized joint spacing ξ increasing. The acceleration amplification coefficient of the slope crest ηcrest does not monotonously increase with the increase of ξ, but decreases with the increase of K. Additionally, ηcrest is more sensitive to ξ compared to K. From the contour figures, it can also be found that the contour figures of η take on rhythm, and the effects of ξ on the acceleration amplification coefficient are more obvious compared to the effects on K.

  9. Estimation of wind speed and wave height during cyclones

    Digital Repository Service at National Institute of Oceanography (India)

    SanilKumar, V.; Mandal, S.; AshokKumar, K.

    reported by ships were comparable. Empirical expressions relating wind speed, wave height and wave period to storm parameters were derived. The design wave height for different return periods was obtained by fitting a two-parameter Weibull distribution...

  10. Shock Waves and Commutation Speed of Memristors

    Science.gov (United States)

    Tang, Shao; Tesler, Federico; Marlasca, Fernando Gomez; Levy, Pablo; Dobrosavljević, V.; Rozenberg, Marcelo

    2016-01-01

    Progress of silicon-based technology is nearing its physical limit, as the minimum feature size of components is reaching a mere 10 nm. The resistive switching behavior of transition metal oxides and the associated memristor device is emerging as a competitive technology for next-generation electronics. Significant progress has already been made in the past decade, and devices are beginning to hit the market; however, this progress has mainly been the result of empirical trial and error. Hence, gaining theoretical insight is of the essence. In the present work, we report the striking result of a connection between the resistive switching and shock-wave formation, a classic topic of nonlinear dynamics. We argue that the profile of oxygen vacancies that migrate during the commutation forms a shock wave that propagates through a highly resistive region of the device. We validate the scenario by means of model simulations and experiments in a manganese-oxide-based memristor device, and we extend our theory to the case of binary oxides. The shock-wave scenario brings unprecedented physical insight and enables us to rationalize the process of oxygen-vacancy-driven resistive change with direct implications for a key technological aspect—the commutation speed.

  11. Bounding the Speed of Gravity with Gravitational Wave Observations

    Science.gov (United States)

    Cornish, Neil; Blas, Diego; Nardini, Germano

    2017-10-01

    The time delay between gravitational wave signals arriving at widely separated detectors can be used to place upper and lower bounds on the speed of gravitational wave propagation. Using a Bayesian approach that combines the first three gravitational wave detections reported by the LIGO Scientific and Virgo Collaborations we constrain the gravitational waves propagation speed cgw to the 90% credible interval 0.55 c light in vacuum. These bounds will improve as more detections are made and as more detectors join the worldwide network. Of order 20 detections by the two LIGO detectors will constrain the speed of gravity to within 20% of the speed of light, while just five detections by the LIGO-Virgo-Kagra network will constrain the speed of gravity to within 1% of the speed of light.

  12. Multi-mode surface wave tomography of the North American upper mantle: 3-D shear wave speed model and radial anisotropy

    Science.gov (United States)

    Yoshizawa, K.; Ekström, G.

    2009-04-01

    The three dimensional shear wave speed structure and radial anisotropy of the upper mantle beneath the North American continent is investigated from automatic measurements of multi-mode phase speeds of Love and Rayleigh waves. We have employed a fully automated method of a nonlinear waveform fitting based on a direct model-parameter search with the neighbourhood algorithm (Yoshizawa and Kennett, 2002a GJI). This method has been applied to long-period three-component records of seismic stations in North America, which mostly comprise the GSN and US regional networks including USArray stations distributed by the IRIS DMC. We have collected over 30,000 path-specific phase speeds of fundamental-mode and higher-mode surface waves in the period range from 30 to 200 seconds. These path-specific phase speeds are then inverted for multi-mode phase speed maps incorporating approximate effects of finite-frequency via the surface-wave influence zone (Yoshizawa and Kennett, 2002b GJI, 2004 JGR), within which surface waves are assumed to be coherent in phase. A 3-D radially anisotropic shear wave speed model is obtained from simultaneous inversions of local dispersion curves of both Love and Rayleigh waves. The preliminary high-resolution 3-D model of North America indicates a large-scale strong velocity contrast between the western and central United States with slow anomalies beneath the Rocky Mountain Range down to 150 km depth and fast anomalies beneath the cratonic areas. Radial anisotropy model shows fast anomalies of vertically polarized shear waves (SV waves) relative to horizontally polarized shear waves (SH waves) beneath the Cascade Range volcanoes down to about 70-100 km, and a similar anomaly beneath the Yellowstone hotspot seems to persist down to about 200-250 km.

  13. Seismic wave speed structure of the Ontong Java Plateau

    Science.gov (United States)

    Covellone, Brian M.; Savage, Brian; Shen, Yang

    2015-06-01

    The Ontong Java Plateau (OJP) represents the result of a significant event in the Earth's geologic history. Limited geophysical and geochemical data, as well as the plateau's relative isolation in the Pacific ocean, have made interpretation of the modern day geologic structure and its 120 Ma formation history difficult. Here we present the highest resolution image to date of the wave speed structure of the OJP region. We use a data set that combines Rayleigh waves extracted from both ambient noise and earthquake waveforms and an iterative finite-frequency tomography methodology. The combination of datasets allow us to best exploit the limited station distribution in the Pacific and image wave speed structures between 35 km and 300 km into the Earth. We image a region of fast shear wave speeds, greater than 4.75 km/s, that extends to greater than 100 km beneath the plateau. The wave speeds are similar to as observed in cratonic environments and are consistent with a compositional anomaly that resulted from the residuum of eclogite entrainment during the plateau's formation. The combination of our imaged wave speed structure and previous geochemical work suggest that a surfacing plume head entrained eclogite from the deep mantle and accounts for the anomalous buoyancy characteristics of the plateau and observed fast wave speeds.

  14. Wave speeds in the macroscopic extended model for ultrarelativistic gases

    Energy Technology Data Exchange (ETDEWEB)

    Borghero, F., E-mail: borghero@unica.it [Dip. Matematica e Informatica, Università di Cagliari, Via Ospedale 72, 09124 Cagliari (Italy); Demontis, F., E-mail: fdemontis@unica.it [Dip. Matematica, Università di Cagliari, Viale Merello 92, 09123 Cagliari (Italy); Pennisi, S., E-mail: spennisi@unica.it [Dip. Matematica, Università di Cagliari, Via Ospedale 72, 09124 Cagliari (Italy)

    2013-11-15

    Equations determining wave speeds for a model of ultrarelativistic gases are investigated. This model is already present in literature; it deals with an arbitrary number of moments and it was proposed in the context of exact macroscopic approaches in Extended Thermodynamics. We find these results: the whole system for the determination of the wave speeds can be divided into independent subsystems which are expressed by linear combinations, through scalar coefficients, of tensors all of the same order; some wave speeds, but not all of them, are expressed by square roots of rational numbers; finally, we prove that these wave speeds for the macroscopic model are the same of those furnished by the kinetic model.

  15. Wave speed in excitable random networks with spatially constrained connections.

    Directory of Open Access Journals (Sweden)

    Nikita Vladimirov

    Full Text Available Very fast oscillations (VFO in neocortex are widely observed before epileptic seizures, and there is growing evidence that they are caused by networks of pyramidal neurons connected by gap junctions between their axons. We are motivated by the spatio-temporal waves of activity recorded using electrocorticography (ECoG, and study the speed of activity propagation through a network of neurons axonally coupled by gap junctions. We simulate wave propagation by excitable cellular automata (CA on random (Erdös-Rényi networks of special type, with spatially constrained connections. From the cellular automaton model, we derive a mean field theory to predict wave propagation. The governing equation resolved by the Fisher-Kolmogorov PDE fails to describe wave speed. A new (hyperbolic PDE is suggested, which provides adequate wave speed v( that saturates with network degree , in agreement with intuitive expectations and CA simulations. We further show that the maximum length of connection is a much better predictor of the wave speed than the mean length. When tested in networks with various degree distributions, wave speeds are found to strongly depend on the ratio of network moments / rather than on mean degree , which is explained by general network theory. The wave speeds are strikingly similar in a diverse set of networks, including regular, Poisson, exponential and power law distributions, supporting our theory for various network topologies. Our results suggest practical predictions for networks of electrically coupled neurons, and our mean field method can be readily applied for a wide class of similar problems, such as spread of epidemics through spatial networks.

  16. Ultrasonic metal sheet thickness measurement without prior wave speed calibration

    Science.gov (United States)

    Dixon, S.; Petcher, P. A.; Fan, Y.; Maisey, D.; Nickolds, P.

    2013-11-01

    Conventional ultrasonic mensuration of sample thickness from one side only requires the bulk wave reverberation time and a calibration speed. This speed changes with temperature, stress, and microstructure, limiting thickness measurement accuracy. Often, only one side of a sample is accessible, making in situ calibration impossible. Non-contact ultrasound can generate multiple shear horizontal guided wave modes on one side of a metal plate. Measuring propagation times of each mode at different transducer separations, allows sheet thickness to be calculated to better than 1% accuracy for sheets of at least 1.5 mm thickness, without any calibration.

  17. Maximum likelihood estimation of shear wave speed in transient elastography.

    Science.gov (United States)

    Audière, Stéphane; Angelini, Elsa D; Sandrin, Laurent; Charbit, Maurice

    2014-06-01

    Ultrasonic transient elastography (TE), enables to assess, under active mechanical constraints, the elasticity of the liver, which correlates with hepatic fibrosis stages. This technique is routinely used in clinical practice to assess noninvasively liver stiffness. The Fibroscan system used in this work generates a shear wave via an impulse stress applied on the surface of the skin and records a temporal series of radio-frequency (RF) lines using a single-element ultrasound probe. A shear wave propagation map (SWPM) is generated as a 2-D map of the displacements along depth and time, derived from the correlations of the sequential 1-D RF lines, assuming that the direction of propagation (DOP) of the shear wave coincides with the ultrasound beam axis (UBA). Under the assumption of pure elastic tissue, elasticity is proportional to the shear wave speed. This paper introduces a novel approach to the processing of the SWPM, deriving the maximum likelihood estimate of the shear wave speed when comparing the observed displacements and the estimates provided by the Green's functions. A simple parametric model is used to interface Green's theoretical values of noisy measures provided by the SWPM, taking into account depth-varying attenuation and time-delay. The proposed method was evaluated on numerical simulations using a finite element method simulator and on physical phantoms. Evaluation on this test database reported very high agreements of shear wave speed measures when DOP and UBA coincide.

  18. Weakly Nonlinear Waves with Slowly-Varying Speed | Chikwendu ...

    African Journals Online (AJOL)

    A previously developed method of generating uniformly valid, multiple- scale asymptotic expansions for the solution of weakly nonlinear one-dimensional wave equations is applied to problems with slowly-varying speed. The method is also shown to be applicable specifically to periodic initial data.

  19. High-speed measurement of firearm primer blast waves

    CERN Document Server

    Courtney, Michael; Eng, Jonathan; Courtney, Amy

    2012-01-01

    This article describes a method and results for direct high-speed measurements of firearm primer blast waves employing a high-speed pressure transducer located at the muzzle to record the blast pressure wave produced by primer ignition. Key findings are: 1) Most of the lead styphnate based primer models tested show 5.2-11.3% standard deviation in the magnitudes of their peak pressure. 2) In contrast, lead-free diazodinitrophenol (DDNP) based primers had standard deviations of the peak blast pressure of 8.2-25.0%. 3) Combined with smaller blast waves, these large variations in peak blast pressure of DDNP-based primers led to delayed ignition and failure to fire in brief field tests.

  20. Performance analysis of WAVE communication under high-speed driving

    Directory of Open Access Journals (Sweden)

    Bo-young Kang

    2017-12-01

    Full Text Available Although WAVE (Wireless Access in Vehicular Environments is a technology designed for the high-speed mobile environments, WAVE communication performance in a real road environment is highly dependent on the surrounding environments such as moving vehicles, road shape, and topography. In particular, when a vehicle moves at high speed, the location of the vehicle and its proximity to the road-side device are rapidly changed and thus affect communication performance. Accordingly, we build a performance evaluation system based on the WAVE-LTE network cooperative operation. We also analyzed the performance differences based on external environmental factors, such as information volume and velocity, from the data acquired through actual vehicle tests.

  1. Speed of transverse waves in a string revisited

    Science.gov (United States)

    Rizcallah, Joseph A.

    2017-11-01

    In many introductory-level physics textbooks, the derivation of the formula for the speed of transverse waves in a string is either omitted altogether or presented under physically overly idealized assumptions about the shape of the considered wave pulse and the related velocity and acceleration distributions. In this paper, we derive the named formula by applying Newton’s second law or the work-energy theorem to a finite element of the string, making no assumptions about the shape of the wave. We argue that the suggested method can help the student gain a deeper insight into the nature of waves and the related process of energy transport, as well as provide a new experience with the fundamental principles of mechanics as applied to extended and deformable bodies.

  2. Radio Wave Propagation Scene Partitioning for High-Speed Rails

    Directory of Open Access Journals (Sweden)

    Bo Ai

    2012-01-01

    Full Text Available Radio wave propagation scene partitioning is necessary for wireless channel modeling. As far as we know, there are no standards of scene partitioning for high-speed rail (HSR scenarios, and therefore we propose the radio wave propagation scene partitioning scheme for HSR scenarios in this paper. Based on our measurements along the Wuhan-Guangzhou HSR, Zhengzhou-Xian passenger-dedicated line, Shijiazhuang-Taiyuan passenger-dedicated line, and Beijing-Tianjin intercity line in China, whose operation speeds are above 300 km/h, and based on the investigations on Beijing South Railway Station, Zhengzhou Railway Station, Wuhan Railway Station, Changsha Railway Station, Xian North Railway Station, Shijiazhuang North Railway Station, Taiyuan Railway Station, and Tianjin Railway Station, we obtain an overview of HSR propagation channels and record many valuable measurement data for HSR scenarios. On the basis of these measurements and investigations, we partitioned the HSR scene into twelve scenarios. Further work on theoretical analysis based on radio wave propagation mechanisms, such as reflection and diffraction, may lead us to develop the standard of radio wave propagation scene partitioning for HSR. Our work can also be used as a basis for the wireless channel modeling and the selection of some key techniques for HSR systems.

  3. Measurement of sound speed vs. depth in South Pole ice: pressure waves and shear waves

    Energy Technology Data Exchange (ETDEWEB)

    IceCube Collaboration; Klein, Spencer

    2009-06-04

    We have measured the speed of both pressure waves and shear waves as a function of depth between 80 and 500 m depth in South Pole ice with better than 1% precision. The measurements were made using the South Pole Acoustic Test Setup (SPATS), an array of transmitters and sensors deployed in the ice at the South Pole in order to measure the acoustic properties relevant to acoustic detection of astrophysical neutrinos. The transmitters and sensors use piezoceramics operating at {approx}5-25 kHz. Between 200 m and 500 m depth, the measured profile is consistent with zero variation of the sound speed with depth, resulting in zero refraction, for both pressure and shear waves. We also performed a complementary study featuring an explosive signal propagating vertically from 50 to 2250 m depth, from which we determined a value for the pressure wave speed consistent with that determined for shallower depths, higher frequencies, and horizontal propagation with the SPATS sensors. The sound speed profile presented here can be used to achieve good acoustic source position and emission time reconstruction in general, and neutrino direction and energy reconstruction in particular. The reconstructed quantities could also help separate neutrino signals from background.

  4. CONNECTION BETWEEN THE SHOCK WAVE SPEED AND II TYPE RADIO BURSTS DRIFT VELOCITY

    OpenAIRE

    E. A. Isaeva; Kravetz, R. O.

    2016-01-01

    The substantial arguments of strong connection between shock wave speed and drift velocity of II type radio bursts in 25-180 MHz range are presented. The studied sample has included 112 proton events that were accompanied with coronal shock waves. To evaluate drift velocity and shock wave speed there was used original records of dynamic spectra from radio spectrograph in 25- 180 MHz range. The velocities of shock waves were evaluated with the power mode model of solar corona density falloff.

  5. Speed of Gravitational Waves from Strongly Lensed Gravitational Waves and Electromagnetic Signals

    Science.gov (United States)

    Fan, Xi-Long; Liao, Kai; Biesiada, Marek; Piórkowska-Kurpas, Aleksandra; Zhu, Zong-Hong

    2017-03-01

    We propose a new model-independent measurement strategy for the propagation speed of gravitational waves (GWs) based on strongly lensed GWs and their electromagnetic (EM) counterparts. This can be done in two ways: by comparing arrival times of GWs and their EM counterparts and by comparing the time delays between images seen in GWs and their EM counterparts. The lensed GW-EM event is perhaps the best way to identify an EM counterpart. Conceptually, this method does not rely on any specific theory of massive gravitons or modified gravity. Its differential setting (i.e., measuring the difference between time delays in GW and EM domains) makes it robust against lens modeling details (photons and GWs travel in the same lensing potential) and against internal time delays between GW and EM emission acts. It requires, however, that the theory of gravity is metric and predicts gravitational lensing similar to general relativity. We expect that such a test will become possible in the era of third-generation gravitational-wave detectors, when about 10 lensed GW events would be observed each year. The power of this method is mainly limited by the timing accuracy of the EM counterpart, which for kilonovae is around 1 04 s . This uncertainty can be suppressed by a factor of ˜1 010, if strongly lensed transients of much shorter duration associated with the GW event can be identified. Candidates for such short transients include short γ -ray bursts and fast radio bursts.

  6. Speed of Gravitational Waves from Strongly Lensed Gravitational Waves and Electromagnetic Signals.

    Science.gov (United States)

    Fan, Xi-Long; Liao, Kai; Biesiada, Marek; Piórkowska-Kurpas, Aleksandra; Zhu, Zong-Hong

    2017-03-03

    We propose a new model-independent measurement strategy for the propagation speed of gravitational waves (GWs) based on strongly lensed GWs and their electromagnetic (EM) counterparts. This can be done in two ways: by comparing arrival times of GWs and their EM counterparts and by comparing the time delays between images seen in GWs and their EM counterparts. The lensed GW-EM event is perhaps the best way to identify an EM counterpart. Conceptually, this method does not rely on any specific theory of massive gravitons or modified gravity. Its differential setting (i.e., measuring the difference between time delays in GW and EM domains) makes it robust against lens modeling details (photons and GWs travel in the same lensing potential) and against internal time delays between GW and EM emission acts. It requires, however, that the theory of gravity is metric and predicts gravitational lensing similar to general relativity. We expect that such a test will become possible in the era of third-generation gravitational-wave detectors, when about 10 lensed GW events would be observed each year. The power of this method is mainly limited by the timing accuracy of the EM counterpart, which for kilonovae is around 10^{4}  s. This uncertainty can be suppressed by a factor of ∼10^{10}, if strongly lensed transients of much shorter duration associated with the GW event can be identified. Candidates for such short transients include short γ-ray bursts and fast radio bursts.

  7. Shear wave speed imaging of breast lesions: Speed within the lesion, fat-to-lesion speed ratio, or gland-to-lesion speed ratio?

    Science.gov (United States)

    Li, Xiao-Long; Ren, Wei-Wei; Fu, Hui-Jun; He, Ya-Ping; Wang, Qiao; Sun, Li-Ping; Guo, Le-Hang; Liu, Bo-Ji; Fang, Lin; Xu, Hui-Xiong

    2017-01-01

    To evaluate the diagnostic performance of shear wave speed (SWS) within the lesion, fat-to-lesion speed ratio (FLR), and gland-to-lesion speed ratio (GLR) for differentiation between benign and malignant breast lesions using a novel SWS imaging technique. From April 2016 to June 2016, 182 breast lesions were prospectively included in the study. For each lesion, SWS-lesion, FLR, and GLR were calculated. Pathological results were used as the reference standard. Receiver operating characteristic curves (ROC) were plotted to assess the diagnostic performance. Of the 182 lesions, 142 (78.0%) were benign and 40 (22.0%) were malignant. Significant differences were found between benign and malignant lesions in SWS-lesion, FLR and GLR (2.12±0.64 m/s vs 3.87±1.45 m/s, 1.63±0.61 vs 2.60±1.04, and 1.33±0.39 vs 2.08±0.78, respectively. All P lesion, FLR, GLR were 2.88 m/s, 2.31 and 1.51, respectively. The diagnostic performance of SWS-lesion in terms of AUC was the highest (i.e. AUC = 0.845), in comparison with FLR and GLR alone or their combination. The associated sensitivity, specificity, and accuracy for SWS-lesion were 75.0%, 89.4%, and 86.3%, respectively. SWS-lesion is a valuable and sufficient method for differentiation between benign and malignant breast lesions.

  8. High-speed imaging of dynamic shock wave reflection phenomena

    CSIR Research Space (South Africa)

    Naidoo, K

    2010-09-01

    Full Text Available Dynamic shock wave reflection generated by a rapidly pitching wedge in a steady supersonic free stream has been studied with numerical simulation previously. An experimental facility was developed for the investigation of these dynamic phenomena...

  9. Speed ot travelling waves in reaction-diffusion equations

    Energy Technology Data Exchange (ETDEWEB)

    Benguria, R.D.; Depassier, M.C. [Facultad de Fisica, Pontificia Universidad Catolica de Chile, Avda. Vicuna Mackenna 4860, Santiago (Chile); Mendez, V. [Facultat de Ciencies de la Salut, Universidad Internacional de Catalunya, Gomera s/n 08190 Sant Cugat del Valles, Barcelona (Spain)

    2002-07-01

    Reaction diffusion equations arise in several problems of population dynamics, flame propagation and others. In one dimensional cases the systems may evolve into travelling fronts. Here we concentrate on a reaction diffusion equation which arises as a simple model for chemotaxis and present results for the speed of the travelling fronts. (Author)

  10. A typical wave wake from high-speed vessels: its group structure and run-up

    Directory of Open Access Journals (Sweden)

    I. Didenkulova

    2013-02-01

    Full Text Available High-amplitude water waves induced by high-speed vessels are regularly observed in Tallinn Bay, the Baltic Sea, causing intense beach erosion and disturbing marine habitants in the coastal zone. Such a strong impact on the coast may be a result of a certain group structure of the wave wake. In order to understand it, here we present an experimental study of the group structure of these wakes at Pikakari beach, Tallinn Bay. The most energetic vessel waves at this location (100 m from the coast at the water depth 2.7 m have amplitudes of about 1 m and periods of 8–10 s and cause maximum run-up heights on a beach up to 1.4 m. These waves represent frequency modulated packets where the largest and longest waves propagate ahead of other smaller amplitude and period waves. Sometimes the groups of different heights and periods can be separated even within one wave wake event. The wave heights within a wake are well described by the Weibull distribution, which has different parameters for wakes from different vessels. Wave run-up heights can also be described by Weibull distribution and its parameters can be connected to the parameters of the distribution of wave heights 100 m from the coast. Finally, the run-up of individual waves within a packet is studied. It is shown that the specific structure of frequency modulated wave packets, induced by high-speed vessels, leads to a sequence of high wave run-ups at the coast, even when the original wave heights are rather moderate. This feature can be a key to understanding the significant impact on coasts caused by fast vessels.

  11. A Novel Approach to Constrain Near-Surface Seismic Wave Speed Based on Polarization Analysis

    Science.gov (United States)

    Park, S.; Ishii, M.

    2016-12-01

    Understanding the seismic responses of cities around the world is essential for the risk assessment of earthquake hazards. One of the important parameters is the elastic structure of the sites, in particular, near-surface seismic wave speed, that influences the level of ground shaking. Many methods have been developed to constrain the elastic structure of the populated sites or urban basins, and here, we introduce a new technique based on analyzing the polarization content or the three-dimensional particle motion of seismic phases arriving at the sites. Polarization analysis of three-component seismic data was widely used up to about two decades ago, to detect signals and identify different types of seismic arrivals. Today, we have good understanding of the expected polarization direction and ray parameter for seismic wave arrivals that are calculated based on a reference seismic model. The polarization of a given phase is also strongly sensitive to the elastic wave speed immediately beneath the station. This allows us to compare the observed and predicted polarization directions of incoming body waves and infer the near-surface wave speed. This approach is applied to High-Sensitivity Seismograph Network in Japan, where we benchmark the results against the well-log data that are available at most stations. There is a good agreement between our estimates of seismic wave speeds and those from well logs, confirming the efficacy of the new method. In most urban environments, where well logging is not a practical option for measuring the seismic wave speeds, this method can provide a reliable, non-invasive, and computationally inexpensive estimate of near-surface elastic properties.

  12. Traveling waves and spreading speed on a lattice model with age structure

    Directory of Open Access Journals (Sweden)

    Zongyi Wang

    2012-09-01

    Full Text Available In this article, we study a lattice differential model for a single species with distributed age-structure in an infinite patchy environment. Using method of approaches by Diekmann and Thieme, we develop a comparison principle and construct a suitable sub-solution to the given model, and show that there exists a spreading speed of the system which in fact coincides with the minimal wave speed.

  13. Wave-speed-determined flow limitation at peak flow in normal and asthmatic subjects.

    Science.gov (United States)

    Pedersen, O F; Brackel, H J; Bogaard, J M; Kerrebijn, K F

    1997-11-01

    The purpose of this study was to examine whether peak expiratory flow is determined by the wave-speed flow-limiting mechanism. We examined 17 healthy subjects and 11 subjects with stable asthma, the latter treated with inhaled bronchodilators and corticosteroids. We used an esophageal balloon and a Pitot-static probe positioned at five locations between the right lower lobe and midtrachea to obtain dynamic area-transmural pressure (A-Ptm) curves as described (O. F. Pedersen, B. Thiessen, and S. Lyager. J. Appl. Physiol. 52: 357-369, 1982). From these curves we obtained cross-sectional area (A) and airway compliance (Caw = dA/dPtm) at PEF, calculated flow at wave speed (Vws = A[A/(Caw*rho)0.5], where rho is density) and speed index is (SI = V/Vws). In 13 of 15 healthy and in 4 of 10 asthmatic subjects, who could produce satisfactory curves, SI at PEF was > 0.9 at one or more measured positions. Alveolar pressure continued to increase after PEF was achieved, suggesting flow limitation somewhere in the airway in all of these subjects. We conclude that wave speed is reached in central airways at PEF in most subjects, but it cannot be excluded that wave speed is also reached in more peripheral airways.

  14. GyPSuM: A Detailed Tomographic Model of Mantle Density and Seismic Wave Speeds

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, N A; Forte, A M; Boschi, L; Grand, S P

    2010-03-30

    GyPSuM is a tomographic model fo mantle seismic shear wave (S) speeds, compressional wave (P) speeds and detailed density anomalies that drive mantle flow. the model is developed through simultaneous inversion of seismic body wave travel times (P and S) and geodynamic observations while considering realistic mineral physics parameters linking the relative behavior of mantle properties (wave speeds and density). Geodynamic observations include the (up to degree 16) global free-air gravity field, divergence of the tectonic plates, dynamic topography of the free surface, and the flow-induced excess ellipticity of the core-mantle boundary. GyPSuM is built with the philosophy that heterogeneity that most closely resembles thermal variations is the simplest possible solution. Models of the density field from Earth's free oscillations have provided great insight into the density configuration of the mantle; but are limited to very long-wavelength solutions. Alternatively, simply scaling higher resolution seismic images to density anomalies generates density fields that do not satisfy geodynamic observations. The current study provides detailed density structures in the mantle while directly satisfying geodynamic observations through a joint seismic-geodynamic inversion process. Notable density field observations include high-density piles at the base of the superplume structures, supporting the fundamental results of past normal mode studies. However, these features are more localized and lower amplitude than past studies would suggest. When we consider all seismic anomalies in GyPSuM, we find that P and S-wave speeds are strongly correlated throughout the mantle. However, correlations between the high-velocity S zones in the deep mantle ({approx} 2000 km depth) and corresponding P-wave anomalies are very low suggesting a systematic divergence from simplified thermal effects in ancient subducted slab anomalies. Nevertheless, they argue that temperature variations are

  15. Effect of disorder on bulk sound wave speed: a multiscale spectral analysis

    Science.gov (United States)

    Shrivastava, Rohit Kumar; Luding, Stefan

    2017-08-01

    Disorder of size (polydispersity) and mass of discrete elements or particles in randomly structured media (e.g., granular matter such as soil) has numerous effects on the materials' sound propagation characteristics. The influence of disorder on energy and momentum transport, the sound wave speed and its low-pass frequency-filtering characteristics is the subject of this study. The goal is understanding the connection between the particle-microscale disorder and dynamics and the system-macroscale wave propagation, which can be applied to nondestructive testing, seismic exploration of buried objects (oil, mineral, etc.) or to study the internal structure of the Earth. To isolate the longitudinal P-wave mode from shear and rotational modes, a one-dimensional system of equally sized elements or particles is used to study the effect of mass disorder alone via (direct and/or ensemble averaged) real time signals, signals in Fourier space, energy and dispersion curves. Increase in mass disorder (where disorder has been defined such that it is independent of the shape of the probability distribution of masses) decreases the sound wave speed along a granular chain. Energies associated with the eigenmodes can be used to obtain better quality dispersion relations for disordered chains; these dispersion relations confirm the decrease in pass frequency and wave speed with increasing disorder acting opposite to the wave acceleration close to the source.

  16. Variation of Langmuir wave polarization with electron beam speed in type III radio bursts

    Energy Technology Data Exchange (ETDEWEB)

    Malaspina, David M. [Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, CO 80303 (United States); Cairns, Iver H. [School of Physics, University of Sydney, New South Wales 2006 (Australia); Ergun, Robert E. [Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, CO 80303 (United States) and Department of Astrophysical and Planetary Sciences, University of Colorado, Boulder, CO 80303 (United States)

    2013-06-13

    Observations by the twin STEREO spacecraft of in-situ electric field waveforms and radio signatures associated with type III radio bursts have demonstrated that the polarization of electron beam-driven waves near the local plasma frequency depends strongly on the speed of the driving electron beam. We expand upon a previous study by including all radio bursts with in-situ waveforms observed by STEREO in 2011. The expanded data set contains five times more radio bursts (35 up from 7) and three times as many Langmuir waves (663 up from 168). While this expanded study supports the results of the original study, that faster (slower) beam electrons drive waves with strong (weak) electric fields perpendicular to the local magnetic field, the larger data set emphasizes that the observation of strong perpendicular electric fields at high electron beam speeds is probabilistic rather than definite. This property supports the interpretation of wave polarization dependence on beam speed as Langmuir/z-mode waves shifted to small wave number through interaction with turbulent solar wind density fluctuations.

  17. Using high speed smartphone cameras and video analysis techniques to teach mechanical wave physics

    Science.gov (United States)

    Bonato, Jacopo; Gratton, Luigi M.; Onorato, Pasquale; Oss, Stefano

    2017-07-01

    We propose the use of smartphone-based slow-motion video analysis techniques as a valuable tool for investigating physics concepts ruling mechanical wave propagation. The simple experimental activities presented here, suitable for both high school and undergraduate students, allows one to measure, in a simple yet rigorous way, the speed of pulses along a spring and the period of transverse standing waves generated in the same spring. These experiments can be helpful in addressing several relevant concepts about the physics of mechanical waves and in overcoming some of the typical student misconceptions in this same field.

  18. Using High Speed Smartphone Cameras and Video Analysis Techniques to Teach Mechanical Wave Physics

    Science.gov (United States)

    Bonato, Jacopo; Gratton, Luigi M.; Onorato, Pasquale; Oss, Stefano

    2017-01-01

    We propose the use of smartphone-based slow-motion video analysis techniques as a valuable tool for investigating physics concepts ruling mechanical wave propagation. The simple experimental activities presented here, suitable for both high school and undergraduate students, allows one to measure, in a simple yet rigorous way, the speed of pulses…

  19. Effect of disorder on bulk sound wave speed : A multiscale spectral analysis

    NARCIS (Netherlands)

    Shrivastava, Rohit Kumar; Luding, Stefan

    2017-01-01

    Disorder of size (polydispersity) and mass of discrete elements or particles in randomly structured media (e.g., granular matter such as soil) has numerous effects on the materials' sound propagation characteristics. The influence of disorder on energy and momentum transport, the sound wave speed

  20. Swimming Speeds of Waving Cylindrical Tails in Viscous Fluids with Resistance

    CERN Document Server

    Ho, Nguyenho

    2015-01-01

    The mathematical analysis of swimming speeds for microorganisms in a 3D fluid is investigated by studying a cylinder propagating lateral or spiral waves of displacement at zero Reynolds number. Since many microorganisms swim in a highly heterogeneous environment with obstacles to swimming, we study swimming speeds of an infinite cylinder in a fluid governed by the Brinkman equation. This represents the effective flow due to a sparse, stationary network of obstructions (e.g. fibers or polymers) in a Newtonian fluid. For a fixed propagating wave of bending, we find that swimming speeds are enhanced due to the resistance from the obstructions. Additionally, we examine the work done per unit area on the surface of a cylindrical filament and recover the limit for the Stokes case as the resistance goes to zero.

  1. Lunar Laser-Ranging Detection of Light-Speed Anisotropy and Gravitational Waves

    Directory of Open Access Journals (Sweden)

    Cahill R. T.

    2010-04-01

    Full Text Available The Apache Point Lunar Laser-ranging Operation (APOLLO, in NM, can detect photon bounces from retroreflectors on the moon surface to 0.1ns timing resolution. This facility enables not only the detection of light speed anisotropy, which defines a local preferred frame of reference - only in that frame is the speed of light isotropic, but also fluctuations/turbulence (gravitational waves in the flow of the dynamical 3-space relative to local systems/observers. So the APOLLO facility can act as an effective "gravitational wave" detector. A recently published small data set from November 5, 2007, is analysed to characterise both the average anisotropy velocity and the wave/turbulence effects. The results are consistent with some 13 previous detections, with the last and most accurate being from the spacecraft earth-flyby Doppler-shift NASA data.

  2. UNCOVERING THE WAVE NATURE OF THE EIT WAVE FOR THE 2010 JANUARY 17 EVENT THROUGH ITS CORRELATION TO THE BACKGROUND MAGNETOSONIC SPEED

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, X. H.; Feng, X. S.; Jiang, C. W. [SIGMA Weather Group, Sate Key Laboratory of Space Weather, Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190 (China); Wu, S. T.; Wang, A. H. [Center for Space Plasma and Aeronomic Research and Department of Mechanical and Aerospace Engineering, University of Alabama in Huntsville, Huntsville, AL 35899 (United States); Vourlidas, A., E-mail: xhzhao@spaceweather.ac.cn, E-mail: wus@uah.edu [Space Sciences Division, Naval Research Laboratory, Washington, DC 20375 (United States)

    2011-12-01

    An EIT wave, which typically appears as a diffuse brightening that propagates across the solar disk, is one of the major discoveries of the Extreme ultraviolet Imaging Telescope on board the Solar and Heliospheric Observatory. However, the physical nature of the so-called EIT wave continues to be debated. In order to understand the relationship between an EIT wave and its associated coronal wave front, we investigate the morphology and kinematics of the coronal mass ejection (CME)-EIT wave event that occurred on 2010 January 17. Using the observations of the SECCHI EUVI, COR1, and COR2 instruments on board the Solar Terrestrial Relations Observation-B, we track the shape and movements of the CME fronts along different radial directions to a distance of about 15 solar radii (R{sub s} ); for the EIT wave, we determine the propagation of the wave front on the solar surface along different propagating paths. The relation between the EIT wave speed, the CME speed, and the local fast-mode characteristic speed is also investigated. Our results demonstrate that the propagation of the CME front is much faster than that of the EIT wave on the solar surface, and that both the CME front and the EIT wave propagate faster than the fast-mode speed in their local environments. Specifically, we show a significant positive correlation between the EIT wave speed and the local fast-mode wave speed in the propagation paths of the EIT wave. Our findings support that the EIT wave under study is a fast-mode magnetohydrodynamic wave.

  3. Geosat altimeter derived sea surface wind speeds and significant wave heights for the north Indian Ocean and their comparison with in situ data

    Digital Repository Service at National Institute of Oceanography (India)

    Vethamony, P.; Vaithiyanathan, R.; Almeida, A.M.; Santanam, K.; Rao, L.V.G.; Sarkar, A.; Kumar, R.; Gairola, R.M.; Gohil, B.S.

    in Indian Daily Weather Reports (IDWR), and (2) waves measured through shipborne wave recorders (SWR) and wave rider buoys (WRB). However, comparison of monthly averages of Geosat wind speeds and significant wave heights with those of IDWR values over 2...

  4. Mitotic waves in the early embryogenesis ofDrosophila: Bistability traded for speed.

    Science.gov (United States)

    Vergassola, Massimo; Deneke, Victoria E; Di Talia, Stefano

    2018-02-15

    Early embryogenesis of most metazoans is characterized by rapid and synchronous cleavage divisions. Chemical waves of Cdk1 activity were previously shown to spread across Drosophila embryos, and the underlying molecular processes were dissected. Here, we present the theory of the physical mechanisms that control Cdk1 waves in Drosophila The in vivo dynamics of Cdk1 are captured by a transiently bistable reaction-diffusion model, where time-dependent reaction terms account for the growing level of cyclins and Cdk1 activation across the cell cycle. We identify two distinct regimes. The first one is observed in mutants of the mitotic switch. There, waves are triggered by the classical mechanism of a stable state invading a metastable one. Conversely, waves in wild type reflect a transient phase that preserves the Cdk1 spatial gradients while the overall level of Cdk1 activity is swept upward by the time-dependent reaction terms. This unique mechanism generates a wave-like spreading that differs from bistable waves for its dependence on dynamic parameters and its faster speed. Namely, the speed of "sweep" waves strikingly decreases as the strength of the reaction terms increases and scales as the powers 3/4, -1/2, and 7/12 of Cdk1 molecular diffusivity, noise amplitude, and rate of increase of Cdk1 activity in the cell-cycle S phase, respectively. Theoretical predictions are supported by numerical simulations and experiments that couple quantitative measurements of Cdk1 activity and genetic perturbations of the accumulation rate of cyclins. Finally, our analysis bears upon the inhibition required to suppress Cdk1 waves at the cell-cycle pause for the maternal-to-zygotic transition.

  5. Sagnac interferometer as a speed-meter-type, quantum-nondemolition gravitational-wave detector

    Science.gov (United States)

    Chen, Yanbei

    2003-06-01

    According to quantum measurement theory, “speed meters”—devices that measure the momentum, or speed, of free test masses—are immune to the standard quantum limit (SQL). It is shown that a Sagnac-interferometer gravitational-wave detector is a speed meter and therefore in principle it can beat the SQL by large amounts over a wide band of frequencies. It is shown, further, that, when one ignores optical losses, a signal-recycled Sagnac interferometer with Fabry-Perot arm cavities has precisely the same performance, for the same circulating light power, as the Michelson speed-meter interferometer recently invented and studied by Purdue and the author. The influence of optical losses is not studied, but it is plausible that they be fairly unimportant for the Sagnac interferometer, as for other speed meters. With squeezed vacuum (squeeze factor e-2R=0.1) injected into its dark port, the recycled Sagnac interferometer can beat the SQL by a factor (10)≃3 over the frequency band 10 Hz≲f≲150 Hz using the same circulating power Ic˜820 kW as is to be used by the (quantum limited) second-generation Advanced LIGO interferometers—if other noise sources are made sufficiently small. It is concluded that the Sagnac optical configuration, with signal recycling and squeezed-vacuum injection, is an attractive candidate for third-generation interferometric gravitational-wave detectors (LIGO-III and EURO).

  6. Propagation speed of a starting wave in a queue of pedestrians.

    Science.gov (United States)

    Tomoeda, Akiyasu; Yanagisawa, Daichi; Imamura, Takashi; Nishinari, Katsuhiro

    2012-09-01

    The propagation speed of a starting wave, which is a wave of people's successive reactions in the relaxation process of a queue, has an essential role for pedestrians and vehicles to achieve smooth movement. For example, a queue of vehicles with appropriate headway (or density) alleviates traffic jams since the delay of reaction to start is minimized. In this paper, we have investigated the fundamental relation between the propagation speed of a starting wave and the initial density by both our mathematical model built on the stochastic cellular automata and experimental measurements. Analysis of our mathematical model implies that the relation is characterized by the power law αρ-β (β≠1), and the experimental results verify this feature. Moreover, when the starting wave is characterized by the power law (β>1), we have revealed the existence of optimal density, where the required time, i.e., the sum of the waiting time until the starting wave reaches the last pedestrian in a queue and his/her travel time to pass the head position of the initial queue, is minimized. This optimal density inevitably plays a significant role in achieving a smooth movement of crowds and vehicles in a queue.

  7. Waves in high-speed plasmoids in the magnetosheath and at the magnetopause

    Directory of Open Access Journals (Sweden)

    H. Gunell

    2014-08-01

    Full Text Available Plasmoids, defined here as plasma entities with a higher anti-sunward velocity component than the surrounding plasma, have been observed in the magnetosheath in recent years. During the month of March 2007 the Cluster spacecraft crossed the magnetopause near the subsolar point 13 times. Plasmoids with larger velocities than the surrounding magnetosheath were found on seven of these 13 occasions. The plasmoids approach the magnetopause and interact with it. Both whistler mode waves and waves in the lower hybrid frequency range appear in these plasmoids, and the energy density of the waves inside the plasmoids is higher than the average wave energy density in the magnetosheath. When the spacecraft are in the magnetosphere, Alfvénic waves are observed. Cold ions of ionospheric origin are seen in connection with these waves, when the wave electric and magnetic fields combine with the Earth's dc magnetic field to yield an E × B/B2 drift speed that is large enough to give the ions energies above the detection threshold.

  8. Interactions of Cavitation Bubbles Observed by High-Speed Imaging in Shock Wave Lithotripsy

    Science.gov (United States)

    Pishchalnikov, Yuri A.; Sapozhnikov, Oleg A.; Bailey, Michael R.; McAteer, James A.; Williams, James C.; Evan, Andrew P.; Cleveland, Robin O.; Crum, Lawrence A.

    2006-05-01

    A multi-frame high-speed photography was used to investigate the dynamics of cavitation bubbles induced by a passage of a lithotripter shock wave in a water tank. Solitary bubbles in the free field each radiated a shock wave upon collapse, and typically emitted a micro-jet on the rebound following initial collapse. For bubbles in clouds, emitted jets were directed toward neighboring bubbles and could break the spherical symmetry of the neighboring bubbles before they in turn collapsed. Bubbles at the periphery of a cluster underwent collapse before the bubbles at the center. Observations with high-speed imaging confirm previous predictions that bubbles in a cavitation cloud do not cycle independently of one another but instead interact as a dynamic bubble cluster.

  9. Continuous auroral activity related to high speed streams with interplaneraty ALFV&N wave trains

    Science.gov (United States)

    Guarnieri, Fernando L.; Tsurutani, Bruce T.; Gonzalez, Walter D.; Kamide, Yosuke; Zhou, Xiaoyan

    2004-01-01

    We discuss a type of intense magnetospheric/auroral activity that is not always substorms: High-Intensity, Long-Duration, Continuous AE Activity (HILDCAA) events, which occur during high speed solar wind streams. The high speed streams contain large-amplitude, nonlinear Alfvtn waves. Analyses of POLAR UV images, demonstrate that the AE increases/AL decreases in HILDCAAs are not always substorm expansion phases (although some substorms may occur). The associated auroral W energy deposition is throughout a continuous (360') auroral oval. During some image intervals, the dayside aurora is the most remarkable feature. Our hypothesis is that solar wind energy transfer from the solar wind to the magnetosphere/ionosphere is primarily directly driven due to the finite wavelength Alfv6n waves and the rapid dBz/dt variability.

  10. Lunar Laser-Ranging Detection of Light-Speed Anisotropy and Gravitational Waves

    Directory of Open Access Journals (Sweden)

    Cahill R. T.

    2010-04-01

    Full Text Available The Apache Point Lunar Laser-ranging Operation (APOLLO, in NM, can detect pho- ton bounces from retroreflectors on the moon surface to 0.1ns timing resolution. This facility enables not only the detection of light speed anisotropy, which defines a local preferred frame of reference — only in that frame is the speed of light isotropic, but also fluctuations / turbulence (gravitational waves in the flow of the dynamical 3-space rela- tive to local systems / observers. So the APOLLO facility can act as an e ective “gravi- tational wave” detector. A recently published small data set from November 5, 2007, is analysed to characterise both the average anisotropy velocity and the wave / turbulence effects. The results are consistent with some 13 previous detections, with the last and most accurate being from the spacecraft earth-flyby Doppler-shift NASA data.

  11. A New Light-Speed Anisotropy Experiment: Absolute Motion and Gravitational Waves Detected

    Directory of Open Access Journals (Sweden)

    Cahill R. T.

    2006-10-01

    Full Text Available Data from a new experiment measuring the anisotropy of the one-way speed of EM waves in a coaxial cable, gives the speed of light as 300,000 +/- 400 (+/- 20 km/s in a measured direction RA=5.5 +/- 2 hrs, Dec=70 +/- 10 Deg S, is shown to be in excellent agreement with the results from seven previous anisotropy experiments, particularly those of Miller (1925/26, and even those of Michelson and Morley (1887. The Miller gas-mode interferometer results, and those from the RF coaxial cable experiments of Torr and Kolen (1983, De Witte (1991 and the new experiment all reveal the presence of gravitational waves, as indicated by the last +/- variations above, but of a kind different from those supposedly predicted by General Relativity. Miller repeated the Michelson-Morley 1887 gas-mode interferometer experiment and againdetected the anisotropy of the speed of light, primarily in the years 1925/1926 atop Mt.Wilson, California. The understanding of the operation of the Michelson interferometer in gas-mode was only achieved in 2002 and involved a calibration for the interferometer that necessarily involved Special Relativity effects and the refractive index of the gas in the light paths. The results demonstrate the reality of the Fitzgerald-Lorentz contraction as an observer independent relativistic effect. A common misunderstanding is that the anisotropy of the speed of light is necessarily in conflict with Special Relativity and Lorentz symmetry - this is explained. All eight experiments and theory show that we have both anisotropy of the speed of light and relativistic effects, and that a dynamical 3-space exists - that absolute motion through that space has been repeatedly observed since 1887. These developments completely change fundamental physics and our understanding of reality. Modern vacuum-mode Michelson interferometers, particularly the long baseline terrestrial versions, are, by design flaw, incapable of detecting the anisotropy effect and the

  12. Determining the speed of sound in the air by sound wave interference

    Science.gov (United States)

    Silva, Abel A.

    2017-07-01

    Mechanical waves propagate through material media. Sound is an example of a mechanical wave. In fluids like air, sound waves propagate through successive longitudinal perturbations of compression and decompression. Audible sound frequencies for human ears range from 20 to 20 000 Hz. In this study, the speed of sound v in the air is determined using the identification of maxima of interference from two synchronous waves at frequency f. The values of v were correct to 0 °C. The experimental average value of {\\bar{ν }}\\exp =336 +/- 4 {{m}} {{{s}}}-1 was found. It is 1.5% larger than the reference value. The standard deviation of 4 m s-1 (1.2% of {\\bar{ν }}\\exp ) is an improved value by the use of the concept of the central limit theorem. The proposed procedure to determine the speed of sound in the air aims to be an academic activity for physics classes of scientific and technological courses in college.

  13. Spreading Speed, Traveling Waves, and Minimal Domain Size in Impulsive Reaction–Diffusion Models

    KAUST Repository

    Lewis, Mark A.

    2012-08-15

    How growth, mortality, and dispersal in a species affect the species\\' spread and persistence constitutes a central problem in spatial ecology. We propose impulsive reaction-diffusion equation models for species with distinct reproductive and dispersal stages. These models can describe a seasonal birth pulse plus nonlinear mortality and dispersal throughout the year. Alternatively, they can describe seasonal harvesting, plus nonlinear birth and mortality as well as dispersal throughout the year. The population dynamics in the seasonal pulse is described by a discrete map that gives the density of the population at the end of a pulse as a possibly nonmonotone function of the density of the population at the beginning of the pulse. The dynamics in the dispersal stage is governed by a nonlinear reaction-diffusion equation in a bounded or unbounded domain. We develop a spatially explicit theoretical framework that links species vital rates (mortality or fecundity) and dispersal characteristics with species\\' spreading speeds, traveling wave speeds, as well as minimal domain size for species persistence. We provide an explicit formula for the spreading speed in terms of model parameters, and show that the spreading speed can be characterized as the slowest speed of a class of traveling wave solutions. We also give an explicit formula for the minimal domain size using model parameters. Our results show how the diffusion coefficient, and the combination of discrete- and continuous-time growth and mortality determine the spread and persistence dynamics of the population in a wide variety of ecological scenarios. Numerical simulations are presented to demonstrate the theoretical results. © 2012 Society for Mathematical Biology.

  14. An exploratory method for estimating the changing speed of epidemic waves from historical data.

    Science.gov (United States)

    Cliff, Andrew D; Haggett, Peter; Smallman-Raynor, Matthew

    2008-02-01

    Historical data are necessary to establish long-term trends in disease incidence but pose analytical problems since their accuracy and reliability may be poorly specified. A robust measure of the spatial velocity, R(0A), of epidemic waves from space-time series is proposed using binary data. The method was applied to the historical records of influenza morbidity for the island of Iceland over a 61-year period of influenza seasons from 1915-16 to 1975-76. The onset of influenza waves tended to speed up over the period studied and the three pandemic waves associated with viral shifts in influenza A [Spanish influenza H1N1 (1918-19), Asian influenza H2N2 (1957-58) and Hong Kong influenza H3N2 (1968-69)] spread more rapidly around the island and struck earlier in the influenza season than did inter-pandemic waves, even when the latter were equally intensive as measured by total number of cases and case incidence. The potential for using R(0A) in a real-time context is explored using French influenza data. The new measure of wave velocity appears to be applicable to those historical time series where breakdown into regional or local areas is available. The study is being extended to (i) other countries where similar influenza time series are available and (ii) to other diseases within Iceland.

  15. Measurement of the speed and attenuation of the Biot slow wave using a large ultrasonic transmitter

    Science.gov (United States)

    Bouzidi, Youcef; Schmitt, Douglas R.

    2009-08-01

    Two compressional wave modes, a fast P1 and a slow P2, propagate through fluid-saturated porous and permeable media. This contribution focuses on new experimental tests of existing theories describing wave propagation in such media. Updated observations of this P2 mode are obtained through a water-loaded, porous sintered glass bead plate with a novel pair of ultrasonic transducers consisting of a large transmitter and a near-point receiver. The properties of the porous plate are measured in independent laboratory experiments. Waveforms are acquired as a function of the angle of incidence over the range from -50° to +50° with respect to the normal. The porous plate is fully characterized, and the physical properties are used to calculate the wave speeds and attenuations of the P1, the P2, and the shear S waves. Comparisons of theory and observation are further facilitated by numerically modeling the observed waveforms. This modeling method incorporates the frequency and angle of incidence-dependent reflectivity, transmissivity, and transducer edge effects; the modeled waveforms match well those observed. Taken together, this study provides further support for existing poroelastic bulk wave propagation and boundary condition theory. However, observed transmitted P1 and S mode amplitudes could not be adequately described unless the attenuation of the medium's frame was also included. The observed P2 amplitudes could be explained without any knowledge of the solid frame attenuation.

  16. Quantitative ultrasound mapping of regional variations in shear wave speeds of the aging Achilles tendon.

    Science.gov (United States)

    Slane, Laura Chernak; Martin, Jack; DeWall, Ryan; Thelen, Darryl; Lee, Kenneth

    2017-02-01

    Evaluate the effects of aging on healthy Achilles tendon and aponeurosis shear wave speed (SWS), a quantitative metric which reflects tissue elasticity. Shear wave elastography was used to measure spatial variations in Achilles tendon SWS in healthy young (n = 15, 25 ± 4 years), middle-aged (n = 10, 49 ± 4 years) and older (n = 10, 68 ± 5 years) adults. SWS was separately measured in the free Achilles tendon, soleus aponeurosis and gastrocnemius aponeurosis in resting (R), stretched (dorsiflexed 15° from R) and slack (plantarflexed 15° from R) postures. SWS significantly increased with stretch and varied with age in all tendon regions. Slack free tendon SWS was significantly higher in older adults than young adults (p = 0.025). However, stretched soleus aponeurosis SWS was significantly lower in older adults than young adults (p = 0.01). Stretched gastrocnemius aponeurosis SWS was significantly lower in both middle-aged (p = 0.003) and older (p = 0.001) adults, relative to younger adults. These results suggest that aging alters spatial variations in Achilles tendon elasticity, which could alter deformations within the triceps surae muscle-tendon units, thus affecting injury potential. The observed location- and posture-dependent variations highlight the importance of controlling ankle posture and imaging location when using shear wave approaches clinically to evaluate tendon disorders. • Shear wave elastography shows promise as a clinical quantitative ultrasound-based technique. • Aging induces location-dependent changes in Achilles tendon shear wave speed. • Spatial and postural dependence necessitates careful integration of this approach clinically.

  17. Testing the Speed of Gravitational Waves over Cosmological Distances with Strong Gravitational Lensing.

    Science.gov (United States)

    Collett, Thomas E; Bacon, David

    2017-03-03

    Probing the relative speeds of gravitational waves and light acts as an important test of general relativity and alternative theories of gravity. Measuring the arrival time of gravitational waves (GWs) and electromagnetic (EM) counterparts can be used to measure the relative speeds, but only if the intrinsic time lag between emission of the photons and gravitational waves is well understood. Here we suggest a method that does not make such an assumption, using future strongly lensed GW events and EM counterparts; Biesiada et al. [J. Cosmol. Astropart. Phys.10 (2014) 080JCAPBP1475-751610.1088/1475-7516/2014/10/080] forecast that 50-100 strongly lensed GW events will be observed each year with the Einstein Telescope. A single strongly lensed GW event would produce robust constraints on c_{GW}/c_{γ} at the 10^{-7} level, if a high-energy EM counterpart is observed within the field of view of an observing γ-ray burst monitor.

  18. High-speed noncontact acoustic inspection method for civil engineering structure using multitone burst wave

    Science.gov (United States)

    Sugimoto, Tsuneyoshi; Sugimoto, Kazuko; Kosuge, Nobuaki; Utagawa, Noriyuki; Katakura, Kageyoshi

    2017-07-01

    The noncontact acoustic inspection method focuses on the resonance phenomenon, and the target surface is measured by being vibrated with an airborne sound. It is possible to detect internal defects near the surface layer of a concrete structure from a long distance. However, it requires a fairly long measurement time to achieve the signal-to-noise (S/N) ratio just to find some resonance frequencies. In our method using the conventional waveform “single-tone burst wave”, only one frequency was used for one-sound-wave emission to achieve a high S/N ratio using a laser Doppler vibrometer (LDV) at a safe low power (e.g., He-Ne 1 mW). On the other hand, in terms of the difference in propagation velocity between laser light and sound waves, the waveform that can be used for high-speed measurement was devised using plural frequencies for one-sound-wave emission (“multitone burst wave”). The measurement time at 35 measurement points has been dramatically decreased from 210 to 28 s when using this waveform. Accordingly, 7.5-fold high-speed measurement became possible. By some demonstration experiments, we confirmed the effectiveness of our measurement technique.

  19. A stochastic collocation method for the second order wave equation with a discontinuous random speed

    KAUST Repository

    Motamed, Mohammad

    2012-08-31

    In this paper we propose and analyze a stochastic collocation method for solving the second order wave equation with a random wave speed and subjected to deterministic boundary and initial conditions. The speed is piecewise smooth in the physical space and depends on a finite number of random variables. The numerical scheme consists of a finite difference or finite element method in the physical space and a collocation in the zeros of suitable tensor product orthogonal polynomials (Gauss points) in the probability space. This approach leads to the solution of uncoupled deterministic problems as in the Monte Carlo method. We consider both full and sparse tensor product spaces of orthogonal polynomials. We provide a rigorous convergence analysis and demonstrate different types of convergence of the probability error with respect to the number of collocation points for full and sparse tensor product spaces and under some regularity assumptions on the data. In particular, we show that, unlike in elliptic and parabolic problems, the solution to hyperbolic problems is not in general analytic with respect to the random variables. Therefore, the rate of convergence may only be algebraic. An exponential/fast rate of convergence is still possible for some quantities of interest and for the wave solution with particular types of data. We present numerical examples, which confirm the analysis and show that the collocation method is a valid alternative to the more traditional Monte Carlo method for this class of problems. © 2012 Springer-Verlag.

  20. High speed video shooting with continuous-wave laser illumination in laboratory modeling of wind - wave interaction

    Science.gov (United States)

    Kandaurov, Alexander; Troitskaya, Yuliya; Caulliez, Guillemette; Sergeev, Daniil; Vdovin, Maxim

    2014-05-01

    Three examples of usage of high-speed video filming in investigation of wind-wave interaction in laboratory conditions is described. Experiments were carried out at the Wind - wave stratified flume of IAP RAS (length 10 m, cross section of air channel 0.4 x 0.4 m, wind velocity up to 24 m/s) and at the Large Air-Sea Interaction Facility (LASIF) - MIO/Luminy (length 40 m, cross section of air channel 3.2 x 1.6 m, wind velocity up to 10 m/s). A combination of PIV-measurements, optical measurements of water surface form and wave gages were used for detailed investigation of the characteristics of the wind flow over the water surface. The modified PIV-method is based on the use of continuous-wave (CW) laser illumination of the airflow seeded by particles and high-speed video. During the experiments on the Wind - wave stratified flume of IAP RAS Green (532 nm) CW laser with 1.5 Wt output power was used as a source for light sheet. High speed digital camera Videosprint (VS-Fast) was used for taking visualized air flow images with the frame rate 2000 Hz. Velocity air flow field was retrieved by PIV images processing with adaptive cross-correlation method on the curvilinear grid following surface wave profile. The mean wind velocity profiles were retrieved using conditional in phase averaging like in [1]. In the experiments on the LASIF more powerful Argon laser (4 Wt, CW) was used as well as high-speed camera with higher sensitivity and resolution: Optronics Camrecord CR3000x2, frame rate 3571 Hz, frame size 259×1696 px. In both series of experiments spherical 0.02 mm polyamide particles with inertial time 7 ms were used for seeding airflow. New particle seeding system based on utilization of air pressure is capable of injecting 2 g of particles per second for 1.3 - 2.4 s without flow disturbance. Used in LASIF this system provided high particle density on PIV-images. In combination with high-resolution camera it allowed us to obtain momentum fluxes directly from

  1. Study on variation in ship's forward speed under regular waves depending on rudder controller

    Directory of Open Access Journals (Sweden)

    Sung-Soo Kim

    2015-03-01

    Full Text Available The purpose of this research is to compare and analyze the advanced speed of ships with different rudder controller in wavy condition by using a simulation. The commercial simulation tool named AQWA is used to develop the simulation of ship which has 3 degree of freedom. The nonlinear hydrodynamic force acting on hull, the propeller thrust and the rudder force are calculated by the additional subroutine which interlock with the commercial simulation tool, and the regular wave is used as the source of the external force for the simulation. Rudder rotational velocity and autopilot coefficients vary to make the different rudder controller. An advanced speed of ships depending on the rudder controller is analyzed after the autopilot simulations.

  2. Quasi-Biennial Oscillation in Phase Speed, Vertical Tilting, and Form Stress of Equatorial Waves in the Stratosphere

    Science.gov (United States)

    Barton, C.; Cai, M.; Shin, C.

    2013-12-01

    We have diagnosed phase speed, wave tilt, and form drag of atmospheric waves in the equatorial stratosphere using daily fields in the NCEP-NCAR II reanalysis dataset. The time series of phase speed, wave tilt, and form drag, or pressure torque, are studied with respect to the tropical stratospheric quasi-biennial oscillation (QBO) of mean zonal winds. Observed (ground-relative) phase speed values are found to oscillate quasi-biennially such that ground-relative phase speed increases during the local easterly QBO phase and decreases during the local westerly QBO phase. The wave is found to tilt westward during the local westerly phase and eastward during the local easterly phase. Such QBO oscillation of wave tilting is consistent with the well-known fact that Kelvin and mixed Rossby-gravity waves are dominant in the local easterly and westerly phase, respectively. The eastward tilting waves have positive pressure torque, acting to transfer easterly angular momentum downward, while westward tilting waves have negative pressure torque, transferring westerly angular momentum downward during the local westerly phase.

  3. Elastic wave speeds and moduli in polycrystalline ice Ih, si methane hydrate, and sll methane-ethane hydrate

    Science.gov (United States)

    Helgerud, M.B.; Waite, W.F.; Kirby, S.H.; Nur, A.

    2009-01-01

    We used ultrasonic pulse transmission to measure compressional, P, and shear, S, wave speeds in laboratory-formed polycrystalline ice Ih, si methane hydrate, and sll methane-ethane hydrate. From the wave speed's linear dependence on temperature and pressure and from the sample's calculated density, we derived expressions for bulk, shear, and compressional wave moduli and Poisson's ratio from -20 to 15??C and 22.4 to 32.8 MPa for ice Ih, -20 to 15??C and 30.5 to 97.7 MPa for si methane hydrate, and -20 to 10??C and 30.5 to 91.6 MPa for sll methane-ethane hydrate. All three materials had comparable P and S wave speeds and decreasing shear wave speeds with increasing applied pressure. Each material also showed evidence of rapid intergranular bonding, with a corresponding increase in wave speed, in response to pauses in sample deformation. There were also key differences. Resistance to uniaxial compaction, indicated by the pressure required to compact initially porous samples, was significantly lower for ice Ih than for either hydrate. The ice Ih shear modulus decreased with increasing pressure, in contrast to the increase measured in both hydrates ?? 2009.

  4. Characterizing shock waves in hydrogel using high speed imaging and a fiber-optic probe hydrophone

    Science.gov (United States)

    Anderson, Phillip A.; Betney, M. R.; Doyle, H. W.; Tully, B.; Ventikos, Y.; Hawker, N. A.; Roy, Ronald A.

    2017-05-01

    The impact of a stainless steel disk-shaped projectile launched by a single-stage light gas gun is used to generate planar shock waves with amplitudes on the order of 102MPa in a hydrogel target material. These shock waves are characterized using ultra-high-speed imaging as well as a fiber-optic probe hydrophone. Although the hydrogel equation of state (EOS) is unknown, the combination of these measurements with conservation of mass and momentum allows us to calculate pressure. It is also shown that although the hydrogel behaves similarly to water, the use of a water EOS underpredicts pressure amplitudes in the hydrogel by ˜10 % at the shock front. Further, the water EOS predicts pressures approximately 2% higher than those determined by conservation laws for a given value of the shock velocity. Shot to shot repeatability is controlled to within 10%, with the shock speed and pressure increasing as a function of the velocity of the projectile at impact. Thus the projectile velocity may be used as an adequate predictor of shock conditions in future work with a restricted suite of diagnostics.

  5. Construction of the seismic wave-speed model by adjoint tomography beneath the Japanese metropolitan area

    Science.gov (United States)

    Miyoshi, Takayuki

    2017-04-01

    The Japanese metropolitan area has high risks of earthquakes and volcanoes associated with convergent tectonic plates. It is important to clarify detail three-dimensional structure for understanding tectonics and predicting strong motion. Classical tomographic studies based on ray theory have revealed seismotectonics and volcanic tectonics in the region, however it is unknown whether their models reproduce observed seismograms. In the present study, we construct new seismic wave-speed model by using waveform inversion. Adjoint tomography and the spectral element method (SEM) were used in the inversion (e.g. Tape et al. 2009; Peter et al. 2011). We used broadband seismograms obtained at NIED F-net stations for 140 earthquakes occurred beneath the Kanto district. We selected four frequency bands between 5 and 30 sec and used from the seismograms of longer period bands for the inversion. Tomographic iteration was conducted until obtaining the minimized misfit between data and synthetics. Our SEM model has 16 million grid points that covers the metropolitan area of the Kanto district. The model parameters were the Vp and Vs of the grid points, and density and attenuation were updated to new values depending on new Vs in each iteration. The initial model was assumed the tomographic model (Matsubara and Obara 2011) based on ray theory. The source parameters were basically used from F-net catalog, while the centroid times were inferred from comparison between data and synthetics. We simulated the forward and adjoint wavefields of each event and obtained Vp and Vs misfit kernels from their interaction. Large computation was conducted on K computer, RIKEN. We obtained final model (m16) after 16 iterations in the present study. For the waveform improvement, it is clearly shown that m16 is better than the initial model, and the seismograms especially improved in the frequency bands of longer than 8 sec and changed better for seismograms of the events occurred at deeper than a

  6. Preliminary result of P-wave speed tomography beneath North Sumatera region

    Energy Technology Data Exchange (ETDEWEB)

    Jatnika, Jajat [Earth Science Study Program, Institute of Technology Bandung (Indonesia); Indonesian Meteorological, Climatological and Geophysical Agency (MCGA), Jakarta (Indonesia); Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id [Global Geophysical Research Group, Faculty of Mining and Petroleum Engineering, Insitute of Technology Bandung (Indonesia); Wandono [Indonesian Meteorological, Climatological and Geophysical Agency (MCGA), Jakarta (Indonesia)

    2015-04-24

    The structure of P-wave speed beneath the North Sumatra region was determined using P-wave arrival times compiled by MCGA from time periods of January 2009 to December 2012 combining with PASSCAL data for February to May 1995. In total, there are 2,246 local earthquake events with 10,666 P-wave phases from 63 stations seismic around the study area. Ray tracing to estimate travel time from source to receiver in this study by applying pseudo-bending method while the damped LSQR method was used for the tomographic inversion. Based on assessment of ray coverage, earthquakes and stations distribution, horizontal grid nodes was set up of 30×30 km2 for inside the study area and 80×80 km2 for outside the study area. The tomographic inversion results show low Vp anomaly beneath Toba caldera complex region and around the Sumatra Fault Zones (SFZ). These features are consistent with previous study. The low Vp anomaly beneath Toba caldera complex are observed around Mt. Pusuk Bukit at depths of 5 km down to 100 km. The interpretation is these anomalies may be associated with ascending hot materials from subduction processes at depths of 80 km down to 100 km. The obtained Vp structure from local tomography will give valuable information to enhance understanding of tectonic and volcanic in this study area.

  7. Shear-wave elastography for breast masses: local shear wave speed (m/sec) versus Young modulus (kPa)

    Energy Technology Data Exchange (ETDEWEB)

    Youk, Ji Hyun; Son, Eun Ju; Park, Ah Young; Kim, Jeong Ah [Dept. of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2014-03-15

    To evaluate and compare the performance of shear-wave elastography (SWE) for breast masses using the local shear wave speed (m/sec) vs. Young modulus (kPa). A total of 130 breast lesions in 123 women who underwent SWE before ultrasound- guided core needle biopsy or surgical excision were included. With the region-of-interest placed over the stiffest areas of the lesion on SWE, the quantitative mean, maximum, and standard deviation (SD) of the elasticity values were measured in kPa and m/sec for each lesion. The SD was also measured with the region-of-interest including the whole breast lesion (wSD). The area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of each elasticity value measured in kPa and m/sec were compared. Of the 130 lesions, 49 (37.7%) were malignant and 81 (62.3%) were benign. The AUCs for the mean, maximum, and SD of the elasticity values using kPa and m/sec did not differ significantly: mean, 0.974 vs. 0.974; maximum, 0.960 vs. 0.976; SD, 0.916 vs. 0.916. However, the AUC for wSD showed a significant difference: 0.964 (kPa) vs. 0.960 (m/sec) (P=0.036). There was no significant difference in the sensitivity and specificity of the mean, maximum, and wSD of the elasticity values. However, the specificity of the SD was significantly different between the two different measurements: 95.1% (kPa) vs. 87.7% (m/sec) (P=0.031). The quantitative elasticity values measured in kPa and m/sec on SWE showed good diagnostic performance. The specificity of the SD and AUC of the wSD measured in kPa were significantly higher than those measured in m/sec.

  8. Shear-wave elastography for breast masses: local shear wave speed (m/sec) versus Young modulus (kPa).

    Science.gov (United States)

    Youk, Ji Hyun; Son, Eun Ju; Park, Ah Young; Kim, Jeong-Ah

    2014-01-01

    To evaluate and compare the performance of shear-wave elastography (SWE) for breast masses using the local shear wave speed (m/sec) vs. Young modulus (kPa). A total of 130 breast lesions in 123 women who underwent SWE before ultrasound- guided core needle biopsy or surgical excision were included. With the region-of-interest placed over the stiffest areas of the lesion on SWE, the quantitative mean, maximum, and standard deviation (SD) of the elasticity values were measured in kPa and m/sec for each lesion. The SD was also measured with the region-of-interest including the whole breast lesion (wSD). The area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of each elasticity value measured in kPa and m/sec were compared. Of the 130 lesions, 49 (37.7%) were malignant and 81 (62.3%) were benign. The AUCs for the mean, maximum, and SD of the elasticity values using kPa and m/sec did not differ significantly: mean, 0.974 vs. 0.974; maximum, 0.960 vs. 0.976; SD, 0.916 vs. 0.916. However, the AUC for wSD showed a significant difference: 0.964 (kPa) vs. 0.960 (m/sec) (P=0.036). There was no significant difference in the sensitivity and specificity of the mean, maximum, and wSD of the elasticity values. However, the specificity of the SD was significantly different between the two different measurements: 95.1% (kPa) vs. 87.7% (m/sec) (P=0.031). The quantitative elasticity values measured in kPa and m/sec on SWE showed good diagnostic performance. The specificity of the SD and AUC of the wSD measured in kPa were significantly higher than those measured in m/sec.

  9. Oltar sv. Wolfganga u Vukovoju

    OpenAIRE

    Repanić Braun, Mirjana; Škarić, Ksenija; Wolff Zubović, Martina; Cavalli Ladašić, Helena

    2013-01-01

    Od 2004. do 2010. godine u Hrvatskom restauratorskom zavodu restauriran je oltar sv. Wolfganga iz kapele u Vukovoju, jedinstveni primjer bogato kićenog manirističkog oltara iz sredine 17. stoljeća u kontinentalnoj Hrvatskoj koji je u neznatno preinačenom stanju sačuvan na izvornom mjestu. Oltar se tradicionalno datira u 1650. godinu, zahvaljujući natpisu ispod slike s drugoga kata. Konzervatorsko-restauratorska istraživanja pokazala su da taj natpis ne pripada polikromiji 17. stoljeća, već je...

  10. Millimeter- and terahertz-wave over fiber technologies for high-speed communication and non-telecom applications

    Science.gov (United States)

    Kanno, Atsushi

    2017-01-01

    Millimeter-wave and terahertz-wave technologies are promising solutions for high-speed wireless communication as well as nondestructive imaging due to its high frequency (short wavelength) nature. In the study, we propose and demonstrate high-speed wireless communication in millimeter- and terahertz-wave bands adopted by advanced optical fiber communication technologies: combination of a radio over fiber (RoF) manner for generation of the signals and a high-speed digital signal processing implemented in a receiver. The RoF technique is also capable for a local-oscillator signal transport over the fiber to the remote sites. Fiber-remoted distributed radar system is also discussed in the paper.

  11. Unseeded Large Scale PIV measurements accounting for capillary-gravity waves phase speed

    CERN Document Server

    Benetazzo,; Gamba,; M.,; Barbariol,; F,

    2016-01-01

    Large Scale Particle Image Velocimetry (LSPIV) is widely recognized as a reliable method to measure water surface velocity field in open channels and rivers. LSPIV technique is based on a camera view that frames the water surface in a sequence, and image-processing methods to compute water surface displacements between consecutive frames. Using LSPIV, high flow velocities, as for example flood conditions, were accurately measured, whereas determinations of low flow velocities is more challenging, especially in absence of floating seeding transported by the flow velocity. In fact, in unseeded conditions, typical surface features dynamics must be taken into account: besides surface structures convected by the current, capillary-gravity waves travel in all directions, with their own dynamics. Discrimination between all these phenomena is here discussed, providing a new method to distinguish and to correct unseeded LSPIV measurements associated with wavy structures, accounting for their phase speed magnitude and ...

  12. Variational integrators for the dynamics of thermo-elastic solids with finite speed thermal waves

    Energy Technology Data Exchange (ETDEWEB)

    Mata, Pablo [Department of Mechanical Engineering, Stanford University, Stanford, CA 94305-4040 (United States); Centro de Investigación en Ecosistemas de la Patagonia (CIEP), Conicyt Regional/CIEP R10C1003, Universidad Austral de Chile, Ignacio Serrrano 509, Coyhaique (Chile); Lew, Adrian J., E-mail: lewa@stanford.edu [Department of Mechanical Engineering, Stanford University, Stanford, CA 94305-4040 (United States)

    2014-01-15

    This paper formulates variational integrators for finite element discretizations of deformable bodies with heat conduction in the form of finite speed thermal waves. The cornerstone of the construction consists in taking advantage of the fact that the Green–Naghdi theory of type II for thermo-elastic solids has a Hamiltonian structure. Thus, standard techniques to construct variational integrators can be applied to finite element discretizations of the problem. The resulting discrete-in-time trajectories are then consistent with the laws of thermodynamics for these systems: for an isolated system, they exactly conserve the total entropy, and nearly exactly conserve the total energy over exponentially long periods of time. Moreover, linear and angular momenta are also exactly conserved whenever the exact system does. For definiteness, we construct an explicit second-order accurate algorithm for affine tetrahedral elements in two and three dimensions, and demonstrate its performance with numerical examples.

  13. Wave propagation speeds and source term influences in single and integral porosity shallow water equations

    Directory of Open Access Journals (Sweden)

    Ilhan Özgen

    2017-10-01

    Full Text Available In urban flood modeling, so-called porosity shallow water equations (PSWEs, which conceptually account for unresolved structures, e.g., buildings, are a promising approach to addressing high CPU times associated with state-of-the-art explicit numerical methods. The PSWE can be formulated with a single porosity term, referred to as the single porosity shallow water model (SP model, which accounts for both the reduced storage in the cell and the reduced conveyance, or with two porosity terms: one accounting for the reduced storage in the cell and another accounting for the reduced conveyance. The latter form is referred to as an integral or anisotropic porosity shallow water model (AP model. The aim of this study was to analyze the differences in wave propagation speeds of the SP model and the AP model and the implications of numerical model results. First, augmented Roe-type solutions were used to assess the influence of the source terms appearing in both models. It is shown that different source terms have different influences on the stability of the models. Second, four computational test cases were presented and the numerical models were compared. It is observed in the eigenvalue-based analysis as well as in the computational test cases that the models converge if the conveyance porosity in the AP model is close to the storage porosity. If the porosity values differ significantly, the AP model yields different wave propagation speeds and numerical fluxes from those of the BP model. In this study, the ratio between the conveyance and storage porosities was determined to be the most significant parameter.

  14. Acoustic model of micro-pressure wave emission from a high-speed train tunnel

    Science.gov (United States)

    Miyachi, T.

    2017-03-01

    The micro-pressure wave (MPW) radiated from a tunnel portal can, if audible, cause serious problems around tunnel portals in high-speed railways. This has created a need to develop an acoustic model that considers the topography around a radiation portal in order to predict MPWs more accurately and allow for higher speed railways in the future. An acoustic model of MPWs based on linear acoustic theory is developed in this study. First, the directivity of sound sources and the acoustical effect of topography are investigated using a train launcher facility around a portal on infinitely flat ground and with an infinite vertical baffle plate. The validity of linear acoustic theory is then discussed through a comparison of numerical results obtained using the finite difference method (FDM) and experimental results. Finally, an acoustic model is derived that considers sound sources up to the second order and Green's function to represent the directivity and effect of topography, respectively. The results predicted by this acoustic model are shown to be in good agreement with both numerical and experimental results.

  15. A comparison between directly measured and inferred wave speeds from an acoustic propagation experiment in Currituck Sound.

    Science.gov (United States)

    Ballard, Megan S; Costley, R Daniel; Sagers, Jason D; Lee, Kevin M; McNeese, Andrew R; Hathaway, Kent K; Wilson, Preston S; Smith, Eric W

    2018-01-01

    An acoustic propagation experiment was conducted in Currituck Sound to characterize low-frequency propagation in a very-shallow-water estuarine environment. The water column properties were homogeneous over the study area, and the emphasis of this work is on understanding the propagation effects induced by the estuarine bed. During the experiment, low-frequency sound propagation measurements of waterborne sound and interface waves were acquired, and direct measurements of the compressional and shear wave properties were obtained at high frequencies. The propagation data consist of signals from a Combustive Sound Source recorded on bottom mounted geophones and a vertical line array of hydrophones. A statistical inference method was applied to obtain an estimate of the sediment compressional and shear wave speed profiles as a function of depth within the estuarine bed. The direct measurements were obtained in situ by inserting probes 30 cm into the sediment. Sediment acoustics models were fit to the high-frequency in situ data to enable comparison with the inferred low-frequency wave speeds. Overall, good agreement was found between the directly measured and inferred wave speeds for both the compressional and shear wave data.

  16. The existence of minimum speed of traveling wave solutions to a non-KPP isothermal diffusion system

    Science.gov (United States)

    Chen, Xinfu; Liu, Guirong; Qi, Yuanwei

    2017-08-01

    The reaction-diffusion system at =axx - abn ,bt = Dbxx + abn, where n ≥ 1 and D > 0, arises from many real-world chemical reactions. Whereas n = 1 is the KPP type nonlinearity, which is much studied and very important results obtained in literature not only in one dimensional spatial domains, but also multi-dimensional spaces, but n > 1 proves to be much harder. One of the interesting features of the system is the existence of traveling wave solutions. In particular, for the traveling wave solution a (x , t) = a (x - vt), b (x , t) = b (x - vt), where v > 0, if we fix lim x → - ∞ ⁡ (a , b) = (0 , 1) it was proved by many authors with different bounds v* (n , D) > 0 such that a traveling wave solution exists for any v ≥v* when n > 1. For the latest progress, see [7]. That is, the traveling wave problem exhibits the mono-stable phenomenon for traveling wave of scalar equation ut =uxx + f (u) with f (0) = f (1) = 0, f (u) > 0 in (0 , 1) and, u = 0 is unstable and u = 1 is stable. A natural and significant question is whether, like the scalar case, there exists a minimum speed. That is, whether there exists a minimum speed vmin > 0 such that traveling wave solution of speed v exists iff v ≥vmin? This is an open question, in spite of many works on traveling wave of the system in last thirty years. This is duo to the reason, unlike the KPP case, the minimum speed cannot be obtained through linear analysis at equilibrium points (a , b) = (0 , 1) and (a , b) = (1 , 0). In this work, we give an affirmative answer to this question.

  17. The seismic wave speed structure of the Ontong Java Plateau determined from joint ambient noise and earthquake waveform data

    Science.gov (United States)

    Covellone, B. M.; Savage, B. K.; Shen, Y.

    2014-12-01

    The Ontong Java Plateau (OJP) represents the result of a significant event in the Earth's geologic history. Limited geophysical and geochemical data, as well as the plateau's relative isolation in the Pacific Ocean, have made interpretation of the modern day geologic structure and its 120 Ma formation history difficult. Here we present the highest resolution images to date of the wave speed structure of the OJP region. We use an iterative finite-frequency tomography methodology and a unique data set that combines empirical Green's functions extracted from ambient noise and earthquake waveforms. The uniqueness and combination of datasets allow us to best exploit the limited station distribution in the Pacific and image wave speed structures between 35 km and greater than 250 km into the Earth. We image a region of fast shear wave speeds, greater than 4.75 km/s, that extends to greater than 100 km beneath the plateau. The wave speeds are similar to as observed in cratonic environments and are consistent with a compositional anomaly likely a result of eclogite entrainment during the plateau's formation.

  18. "Slowing" Mechanical Waves with a Consumer-Type High-Speed Digital Camera

    Science.gov (United States)

    Ng, Pun-hon; Chan, Kin-lok

    2015-01-01

    In most secondary physics textbooks, waves are first introduced with examples of mechanical waves because they can be illustrated by drawings and photographs. However, these illustrations are static and cannot reflect the dynamic nature of waves. Although many mechanical waves (e.g. water waves and vibrating strings) can be easily shown using…

  19. Ultra-High-Speed Travelling Wave Protection of Transmission Line Using Polarity Comparison Principle Based on Empirical Mode Decomposition

    Directory of Open Access Journals (Sweden)

    Dong Wang

    2015-01-01

    Full Text Available The traditional polarity comparison based travelling wave protection, using the initial wave information, is affected by initial fault angle, bus structure, and external fault. And the relationship between the magnitude and polarity of travelling wave is ignored. Because of the protection tripping and malfunction, the further application of this protection principle is affected. Therefore, this paper presents an ultra-high-speed travelling wave protection using integral based polarity comparison principle. After empirical mode decomposition of the original travelling wave, the first-order intrinsic mode function is used as protection object. Based on the relationship between the magnitude and polarity of travelling wave, this paper demonstrates the feasibility of using travelling wave magnitude which contains polar information as direction criterion. And the paper integrates the direction criterion in a period after fault to avoid wave head detection failure. Through PSCAD simulation with the typical 500 kV transmission system, the reliability and sensitivity of travelling wave protection were verified under different factors’ affection.

  20. Archaeomagnetic SV curve for Belgium

    Science.gov (United States)

    Ech-chakrouni, Souad; Hus, Jozef

    2017-04-01

    Archaeomagnetic secular variation curves have been established for different countries in Europe, especially when different archeological sites are more or less uniformly distributed in time are available. The disadvantage in that case is that data had to be relocated to a single reference site. The proximity of the reference locality Paris to Belgium makes that we used the French archaeomagnetic SV curve for the last three millennia up to the present for archaeomagnetic dating undated baked structures. In total, 85 baked structures have been examined, unearthed in 24 archaeological sites of the territory of Belgium. The ChRM of each sample was obtained by principal component analysis for at least three demagnetisation steps (Kirschvink 1980). Except for some outliers, the ChRM directions are very coherent with a high confidence factor (α95Belgium with Uccle as reference locality, where the first measurement of the geomagnetic field was done in 1895. This curve would include all the available reference data in a radius of about 500 km around Uccle. Keywords: secular variation, archaeomagnetic dating, Belgium.

  1. Diffusive Cosmic-Ray Acceleration at Shock Waves of Arbitrary Speed with Magnetostatic Turbulence. I. General Theory and Correct Nonrelativistic Speed Limit

    Science.gov (United States)

    Schlickeiser, R.; Oppotsch, J.

    2017-12-01

    The analytical theory of diffusive acceleration of cosmic rays at parallel stationary shock waves of arbitrary speed with magnetostatic turbulence is developed from first principles. The theory is based on the diffusion approximation to the gyrotropic cosmic-ray particle phase-space distribution functions in the respective rest frames of the up- and downstream medium. We derive the correct cosmic-ray jump conditions for the cosmic-ray current and density, and match the up- and downstream distribution functions at the position of the shock. It is essential to account for the different particle momentum coordinates in the up- and downstream media. Analytical expressions for the momentum spectra of shock-accelerated cosmic rays are calculated. These are valid for arbitrary shock speeds including relativistic shocks. The correctly taken limit for nonrelativistic shock speeds leads to a universal broken power-law momentum spectrum of accelerated particles with velocities well above the injection velocity threshold, where the universal power-law spectral index q≃ 2-{γ }1-4 is independent of the flow compression ratio r. For nonrelativistic shock speeds, we calculate for the first time the injection velocity threshold, settling the long-standing injection problem for nonrelativistic shock acceleration.

  2. Experimental study on incident wave speed and the mechanisms of deflagration-to-detonation transition in a bent geometry

    Science.gov (United States)

    Li, L.; Li, J.; Teo, C. J.; Chang, P. H.; Khoo, B. C.

    2017-04-01

    The study of deflagration-to-detonation transition (DDT) in bent tubes is important with many potential applications including fuel pipeline and mine tunnel designs for explosion prevention and detonation engines for propulsion. The aim of this study is to exploit low-speed incident shock waves for DDT using an S-shaped geometry and investigate its effectiveness as a DDT enhancement device. Experiments were conducted in a valveless detonation chamber using ethylene-air mixture at room temperature and pressure (303 K, 1 bar). High-speed Schlieren photography was employed to keep track of the wave dynamic evolution. Results showed that waves with velocity as low as 500 m/s can experience a successful DDT process through this S-shaped geometry. To better understand the mechanism, clear images of local explosion processes were captured in either the first curved section or the second curved section depending on the inlet wave velocity, thus proving that this S-shaped tube can act as a two-stage device for DDT. Owing to the curved wall structure, the passing wave was observed to undergo a continuous compression phase which could ignite the local unburnt mixture and finally lead to a local explosion and a detonation transition. Additionally, the phenomenon of shock-vortex interaction near the wave diffraction region was also found to play an important role in the whole process. It was recorded that this interaction could not only result in local head-on reflection of the reflected wave on the wall that could ignite the local mixture, and it could also contribute to the recoupling of the shock-flame complex when a detonation wave is successfully formed in the first curved section.

  3. Noninvasive measurement of wave speed of porcine cornea in ex vivo porcine eyes for various intraocular pressures.

    Science.gov (United States)

    Zhou, Boran; Sit, Arthur J; Zhang, Xiaoming

    2017-11-01

    The objective of this study was to extend an ultrasound surface wave elastography (USWE) technique for noninvasive measurement of ocular tissue elastic properties. In particular, we aim to establish the relationship between the wave speed of cornea and the intraocular pressure (IOP). Normal ranges of IOP are between 12 and 22mmHg. Ex vivo porcine eye balls were used in this research. The porcine eye ball was supported by the gelatin phantom in a testing container. Some water was pour into the container for the ultrasound measurement. A local harmonic vibration was generated on the side of the eye ball. An ultrasound probe was used to measure the wave propagation in the cornea noninvasively. A 25 gauge butterfly needle was inserted into the vitreous humor of the eye ball under the ultrasound imaging guidance. The needle was connected to a syringe. The IOP was obtained by the water height difference between the water level in the syringe and the water level in the testing container. The IOP was adjusted between 5mmHg and 30mmHg with a 5mmHg interval. The wave speed was measured at each IOP for three frequencies of 100, 150 and 200Hz. Finite element method (FEM) was used to simulate the wave propagation in the corneal according to our experimental setup. A linear viscoelastic FEM model was used to compare the experimental data. Both the experiments and the FEM analyses showed that the wave speed of cornea increased with IOP. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves

    Science.gov (United States)

    Song, Shaozhen; Yoon, Soon Joon; Ambroziński, Łukasz; Pelivanov, Ivan; Li, David; Gao, Liang; Shen, Tueng T.; O'Donnell, Matthew; Wang, Ruikang K.

    2017-02-01

    Shear wave OCE (SW-OCE) uses an OCT system to track propagating mechanical waves, providing the information needed to map the elasticity of the target sample. In this study we demonstrate high speed, 4D imaging to capture transient mechanical wave propagation. Using a high-speed Fourier domain mode-locked (FDML) swept-source OCT (SS-OCT) system operating at 1.62 MHz A-line rate, the equivalent volume rate of mechanical wave imaging is 16 kvps (kilo-volumes per second), and total imaging time for a 6 x 6 x 3 mm volume is only 0.32 s. With a displacement sensitivity of 10 nanometers, the proposed 4D imaging technique provides sufficient temporal and spatial resolution for real-time optical coherence elastography (OCE). Combined with a new air-coupled, high-frequency focused ultrasound stimulator requiring no contact or coupling media, this near real-time system can provide quantitative information on localized viscoelastic properties. SW-OCE measurements are demonstrated on tissue-mimicking phantoms and porcine cornea under various intra-ocular pressures. In addition, elasticity anisotropy in the cornea is observed. Images of the mechanical wave group velocity, which correlates with tissue elasticity, show velocities ranging from 4-20 m/s depending on pressure and propagation direction. These initial results strong suggest that 4D imaging for real-time OCE may enable high-resolution quantitative mapping of tissue biomechanical properties in clinical applications.

  5. Simvastatin (SV) metabolites in mouse tissues

    Energy Technology Data Exchange (ETDEWEB)

    Duncan, C.A.; Vickers, S. (Merck Sharp and Dohme Research Labs., West Point, PA (United States))

    1990-02-26

    SV, a semisynthetic analog of lovastatin, is hydrolyzed in vivo to its hydroxy acid (SVA), a potent inhibitor of HMG CoA reductase (HR). Thus SV lowers plasma cholesterol. SV is a substrate for mixed function oxidases whereas SVA undergoes lactonization and {beta}-oxidation. Male CD-1 mice were dosed orally with a combination of ({sup 14}C)SV and ({sup 3}H)SVA at 25 mg/kg of each, bled and killed at 0.5, 2 and 4 hours. Labeled SV, SVA, 6{prime}exomethylene SV (I), 6{prime}CH{sub 2}OH-SV (II), 6{prime}COOH-SV (III) and a {beta}-oxidized metabolite (IV) were assayed in liver, bile, kidneys, testes and plasma by RIDA. Levels of potential and active HR inhibitors in liver were 10 to 40 fold higher than in other tissues. II and III, in which the configuration at 6{prime} is inverted, may be 2 metabolites of I. Metabolites I-III are inhibitors of HR in their hydroxy acid forms. Qualitatively ({sup 14}C)SV and ({sup 3}H)SVA were metabolized similarly (consistent with their proposed interconversion). However {sup 3}H-SVA, I-III (including hydroxy acid forms) achieved higher concentrations than corresponding {sup 14}C compounds (except in gall bladder bile). Major radioactive metabolites in liver were II-IV (including hydroxy acid forms). These metabolites have also been reported in rat tissues. In bile a large fraction of either label was unidentified polar metabolites. The presence of IV indicated that mice (like rats) are not good models for SV metabolism in man.

  6. Hull forms and straight forward CFD free running trials of high-speed shuttle vessels

    Directory of Open Access Journals (Sweden)

    WEI Chengzhu

    2017-03-01

    Full Text Available SV-SJTU high-speed shuttle vessels are developed by Shanghai Jiao Tong University for fine seakeeping and high speed purposes. A series of SV-SJTUs have been developed, and are introduced in this paper. Straight forward CFD free running trials were conducted and the results are also presented. Hull resistance and motions are predicted by solving URANS equations and adopting the overset mesh method. The results of the straight forward CFD free running trials prove that SV-SJTUs have little resistance and fine hull motion in calm water, and their wave-making and splashing differ with different hull forms. This paper presents the designs of a variety of high performance ships, thereby providing quantitative and quali-tative references for researchers.

  7. Walkie-Talkie Measurements for the Speed of Radio Waves in Air

    Science.gov (United States)

    Dombi, Andra; Tunyagi, Arthur; Neda, Zoltan

    2013-01-01

    A handheld emitter-receiver device suitable for the direct estimation of the velocity of radio waves in air is presented. The velocity of radio waves is measured using the direct time-of-flight method, without the need for any tedious and precise settings. The results for two measurement series are reported. Both sets of results give an estimate…

  8. Microscopic Theory of Traffic Flow Instability Governing Traffic Breakdown at Highway Bottlenecks: Growing Wave of Increase in Speed in Synchronized Flow

    CERN Document Server

    Kerner, Boris S

    2015-01-01

    We have revealed a growing local speed wave of increase in speed that can randomly occur in synchronized flow (S) at a highway bottleneck. The development of such a traffic flow instability leads to free flow (F) at the bottleneck; therefore, we call this instability as an S$\\rightarrow$F instability. Whereas the S$\\rightarrow$F instability leads to a local {\\it increase in speed} (growing acceleration wave), in contrast, the classical traffic flow instability introduced in 50s--60s and incorporated later in a huge number of traffic flow models leads to a growing wave of a local {\\it decrease in speed} (growing deceleration wave). We have found that the S$\\rightarrow$F instability can occur only, if there is a finite time delay in driver over-acceleration. The initial speed disturbance of increase in speed (called "speed peak") that initiates the S$\\rightarrow$F instability occurs usually at the downstream front of synchronized flow at the bottleneck. There can be many speed peaks with random amplitudes that ...

  9. Setup of an experimental device for high-speed debris flows generating 2D impulse waves

    OpenAIRE

    Bateman Pinzón, Allen; Bregoli, Francesco; Medina Iglesias, Vicente César de; Rast, Manuel; Bentz, Clara

    2011-01-01

    Landslides and debris flows falling into reservoirs, natural lakes, fjords or seas can generate impulse waves, which can be assimilated to tsunami-water waves. Such wave’s behavior can be highly destructive regarding dams and other structures and infrastructures as well as people living along shorelines. Destructive observed past events, such Vajont Dam in Italy (1963) or Lituya Bay in Alaska (1958), are not enough to describe and finally properly prevent the phenomenon. Experimental studies ...

  10. Relationships between seismic wave-Speed, density, and electrical conductivity beneath Australia from seismology, mineralogy, and laboratory-based conductivity profiles

    DEFF Research Database (Denmark)

    Khan, A.; Koch, S.; Shankland, T. J.

    2015-01-01

    We present maps of the three-dimensional density (ρ), electrical conductivity (σ), and shear-wave speed (VS) structure of the mantle beneath Australia and surrounding ocean in the depth range of 100–800 km. These maps derived from stochastic inversion of seismic surface-wave dispersion data, ther...

  11. Trends in significant wave height and surface wind speed in the China Seas between 1988 and 2011

    Science.gov (United States)

    Zheng, Chongwei; Zhang, Ren; Shi, Weilai; Li, Xin; Chen, Xuan

    2017-10-01

    Wind and waves are key components of the climate system as they drive air-sea interactions and influence weather systems and atmospheric circulation. In marine environments, understanding surface wind and wave fields and their evolution over time is important for conducting safe and efficient human activities, such as navigation and engineering. This study considers long-term trends in the sea surface wind speed (WS) and significant wave height (SWH) in the China Seas over the period 1988-2011 using the Cross-Calibrated Multi-Platform (CCMP) ocean surface wind product and a 24-year hindcast wave dataset obtained from the WAVEWATCH-III (WW3) wave model forced with CCMP winds. The long-term trends in WS and SWH in the China Seas are analyzed over the past 24 years to provide a reference point from which to assess future climate change and offshore wind and wave energy resource development in the region. Results demonstrate that over the period 1988-2011 in the China Seas: 1) WS and SWH showed a significant increasing trend of 3.38 cm s-1 yr-1 and 1.52 cm yr-1, respectively; 2) there were notable regional differences in the long-term trends of WS and SWH; 3) areas with strong increasing trends were located mainly in the middle of the Tsushima Strait, the northern and southern areas of the Taiwan Strait, and in nearshore regions of the northern South China Sea; and 4) the long-term trend in WS was closely associated with El Niño and a significant increase in the occurrence of gale force winds in the region.

  12. High interindividual variability in dose-dependent reduction in speed of movement after exposing C. elegans to shock waves

    Directory of Open Access Journals (Sweden)

    Nicholas Baker Angstman

    2015-02-01

    Full Text Available In blast-related mild traumatic brain injury (br-mTBI little is known about the connections between initial trauma and expression of individual clinical symptoms. Partly due to limitations of current in vitro and in vivo models of br-mTBI, reliable prediction of individual short- and long-term symptoms based on known blast input has not yet been possible. Here we demonstrate a dose-dependent effect of shock wave exposure on C. elegans using shock waves that share physical characteristics with those hypothesized to induce br-mTBI in humans. Increased exposure to shock waves resulted in decreased mean speed of movement while increasing the proportion of worms rendered paralyzed. Recovery of these two behavioral symptoms was observed during increasing post-traumatic waiting periods. Although effects were observed on a population-wide basis, large interindividual variability was present between organisms exposed to the same highly controlled conditions. Reduction of cavitation by exposing worms to shock waves in polyvinyl alcohol resulted in reduced effect, implicating primary blast effects as damaging components in shock wave induced trauma. Growing worms on NGM agar plates led to the same general results in initial shock wave effect in a standard medium, namely dose-dependence and high interindividual variability, as raising worms in liquid cultures. Taken together, these data indicate that reliable prediction of individual clinical symptoms based on known blast input as well as drawing conclusions on blast input from individual clinical symptoms is not feasible in br-mTBI.

  13. Wind Profiles and Wave Spectra for Potential Wind Farms in South China Sea. Part I: Wind Speed Profile Model

    Directory of Open Access Journals (Sweden)

    Yichao Liu

    2017-01-01

    Full Text Available With the setting of wind energy harvesting moving from coastal waters to deep waters, the South China Sea has been deemed to offer great potential for the construction of floating wind farms thanks to the abundance of wind energy resources. An engineering model describing the wind profiles and wave spectra specific to the South China Sea conditions, which is the precondition for offshore wind farm construction, has, however, not yet been proposed. In the present study, a series of numerical simulations have been conducted using the Weather Forecast and Research model. Through analyzing the wind and wave information extracted from the numerical simulation results, engineering models to calculate vertical profiles of wind speeds and wave spectra have been postulated. While the present paper focuses on the wind profile model, a companion paper articulates the wave spectrum model. For wind profiles under typhoon conditions, the power-law and log-law models have been found applicable under the condition that the Hellmann exponent α or the friction velocity u * are modified to vary with the wind strength. For wind profiles under non-typhoon conditions, the log-law model is revised to take into consideration the influence of the atmospheric stability.

  14. Columnar structure of SV40 minichromosome

    Directory of Open Access Journals (Sweden)

    Edward N Trifonov

    2015-07-01

    Full Text Available Like the sequence of the strongest 601 clone nucleosome of Lowary and Widom, the SV40 genome sequence contains tracks of YR dinucleotides separated by small integers of the 10.4n base series (10, 11, 21 and 30 bases. The tracks, however, substantially exceed the nucleosome DNA size and, thus, correspond to more extended structure - columnar chromatin. The micrococcal nuclease digests of the SV40 chromatin do not show uniquely positioned individual nucleosomes. This confirms the columnar structure of the minichromosome, as well as earlier electron microscopy studies.

  15. Millimeter Wave Hybrid Photonic Wireless Links for High-Speed Wireless Access and Mobile Fronthaul

    DEFF Research Database (Denmark)

    Rommel, Simon

    require a complete re-thinking of radio access networks – one important aspect of which is the introduction of millimeter wave communications, which is expected to play a key role. Millimeter wave hybrid photonic wireless links seamlessly merge the wired optical and wireless radio network segments...... of spectral efficiency is achieved for rof links in W-band using multi-band carrierless amplitude phase modulation (multicap), the first experimental validation of wavelet coding for robustness against frequency fading is performed, and the combination of multicap with non-orthogonal multiple access...... and combine the best of both technologies, offering very large capacity and bridging long distances with optical fiber, while retaining the flexibility and easy deployment of wireless communications. The research in this thesis experimentally investigates millimeter wave (mmw) hybrid photonic wireless links...

  16. Model tests on resistance and seakeeping performance of wave-piercing high-speed vessel with spray rails

    Directory of Open Access Journals (Sweden)

    Jeonghwa Seo

    2016-09-01

    Full Text Available The resistance and seakeeping performance of a high-speed monohull vessel were investigated through a series of model tests in a towing tank. The hull had a slender wave-piercing bow, round bilge, and small deadrise angle on stern. Tests on the bare hull in calm water were first conducted and tests on spray rails followed. The spray rails were designed to control the flow direction and induce a hydrodynamic lift force on the hull bottom to reduce trim angle and increase rise of the hull. The maximum trim of the bare hull was 4.65° at the designed speed, but the spray rails at optimum location reduced trim by 0.97°. The ship motion in head seas was examined after the calm water tests. Attaching the rails on the optimum location effectively reduced the pitch and heave motion responses. The vertical acceleration at the fore perpendicular reduced by 11.3%. The effective power in full scale was extrapolated from the model test results and it was revealed that the spray rails did not have any negative effects on the resistance performance of the hull, while they effectively stabilized the vessel in calm water and waves.

  17. Effect of Graphite Concentration on Shear-Wave Speed in Gelatin-Based Tissue-Mimicking Phantoms

    Science.gov (United States)

    Anderson, Pamela G.; Rouze, Ned C.; Palmeri, Mark L.

    2011-01-01

    Elasticity-based imaging modalities are becoming popular diagnostic tools in clinical practice. Gelatin-based, tissue mimicking phantoms that contain graphite as the acoustic scattering material are commonly used in testing and validating elasticity-imaging methods to quantify tissue stiffness. The gelatin bloom strength and concentration are used to control phantom stiffness. While it is known that graphite concentration can be modulated to control acoustic attenuation, the impact of graphite concentrationon phantom elasticity has not been characterized in these gelatin phantoms. This work investigates the impact of graphite concentration on phantom shear stiffness as characterized by shear-wave speed measurements using impulsive acoustic-radiation-force excitations. Phantom shear-wave speed increased by 0.83 (m/s)/(dB/(cm MHz)) when increasing the attenuation coefficient slope of the phantom material through increasing graphite concentration. Therefore, gelatin-phantom stiffness can be affected by the conventional ways that attenuation is modulated through graphite concentration in these phantoms. PMID:21710828

  18. Roadside versus in-car speed support for green wave : Driving simulator study

    NARCIS (Netherlands)

    Duivenvoorden, K.; Schaap, N.; Horst, A.R.A. van der; Feenstra, P.; Arem, B. van

    2008-01-01

    A green wave on a road enables a driver to negotiate a sequence of signalized intersections without hitting red. This is accomplished by the coupling of a series of signalized intersections. This is an advantage for driver comfort, for flow and safety on the road network, and for the environment.

  19. Invited Article: Polarization diversity and modulation for high-speed optical communications: architectures and capacity

    Science.gov (United States)

    Shieh, William; Khodakarami, Hamid; Che, Di

    2016-07-01

    Polarization is one of the fundamental properties of optical waves. To cope with the exponential growth of the Internet traffic, optical communications has advanced by leaps and bounds within the last decade. For the first time, the polarization domain has been extensively explored for high-speed optical communications. In this paper, we discuss the general principle of polarization modulation in both Jones and Stokes spaces. We show that there is no linear optical device capable of transforming an arbitrary input polarization into one that is orthogonal to itself. This excludes the receiver self-polarization diversity architecture by splitting the signal into two branches, and then transferring one of the branches into orthogonal polarization. We next propose a novel Stokes vector (SV) detection architecture using four single-ended photodiodes (PD) that can recover a full set of SV. We then derive a closed-form expression for the information capacity of different SV detection architectures and compare the capacity of our proposed architectures with that of intensity-modulated directly-detected (IM/DD) method. We next study the 3-PD SV detection architecture where a subset of SV is detected, and devise a novel modulation algorithm that can achieve 2-dimensional modulation with the 3-PD detection. By using cost-effective SV receivers, polarization modulation and multiplexing offers a powerful solution for short-reach optical networks where the wavelength domain is quickly exhausted.

  20. TRENDS IN THE DEVELOPMENT OF DETONATION ENGINES FOR HIGH-SPEED AEROSPACE AIRCRAFTS AND THE PROBLEM OF TRIPLE CONFIGURATIONS OF SHOCK WAVES. Part II - Research of counterpropagating shock waves and triple shock wave configurations

    Directory of Open Access Journals (Sweden)

    P. V. Bulat

    2016-03-01

    Full Text Available The paper deals with current issues of the interference theory development of gas-dynamic discontinuities as applied to a problem of propulsion refinement for the air-spacecrafts, designed for hypersonic flight speeds. In the first part of the review we have presented the history of detonation study and different concepts of detonation engines, as well as air intakes designed for hypersonic flight speeds. The second part provides an overview of works on the interference theory development for gas-dynamic discontinuities. We report about classification of the gas-dynamic discontinuities, shock wave propagation, shock-wave structures and triple configurations of shock waves. We have shown that many of these processes are accompanied by a hysteresis phenomenon, there are areas of ambiguity; therefore, in the design of engines and air intakes optimal shock-wave structures should be provided and their sustainability should be ensured. Much attention has recently been given to the use of the air intakes in the shock-wave structures with the rereflection of shock waves and the interference of shock waves in the opposite directions. This review provides increased focus on it, contains references to landmark works, the last calculated and experimental results. Unfortunately, foreign surveys missed many landmark works of the Soviet and Russian researchers, as they were not published in English. At the same time, it was the Soviet school of gas dynamics that has formulated the interference theory of gas-dynamic discontinuities in its present form. To fill this gap is one of this review scopes. The review may be recommended for professionals, engineers and scientists working in the field of aerospace engineering.

  1. An accurate procedure for estimating the phase speed of ocean waves from observations by satellite borne altimeters

    Science.gov (United States)

    De-Leon, Yair; Paldor, Nathan

    2017-08-01

    Observations of sea surface height (SSH) fields using satellite borne altimeters were conducted starting in the 1990s in various parts of the world ocean. Currently, a long period of 20 years of calibrated and accurate altimeter observations of Sea Surface Height Anomalies (SSHA) is publically available and ready to be examined for determining the rate of westward propagation of these anomalies, which are interpreted as a surface manifestation of linear Rossby waves that propagate westward in the ocean thermocline or as nonlinear eddies. The basis for estimating the speed of westward propagation of SSHA is time-longitude (Hovmöller) diagrams of the SSHA field at fixed latitude. In such a diagram the westward propagation is evident from a left-upward tilt of constant SSHA values (i.e. contours) and the angle between this tilt and the ordinate is directly proportional to the speed of westward propagation. In this work we use synthetically generated noisy data to examine the accuracy of three different methods that have been separately used in previous studies for estimating this slope (angle) of the time-longitude diagram: The first is the application of Radon transform, used in image processing for detecting structures on an image. The second method is the application of 2D Fast Fourier Transform that yields a frequency-wavenumber diagram of the amplitudes so the frequency and wavenumber where the maximum amplitude occurs determine the phase speed i.e. the slope. The third method constitutes an adaptation of Radon transform to a propagating wave in which structures of minimal variance in the image are identified. The three methods do not always yield the same phase speed value and our analysis of the synthetic data shows that an estimate of the phase speed at any given latitude should be considered valid only when at least two of the methods yield the same value. The relevance of the suggested procedure to observed signals is verified by applying it to observed

  2. Traveling at the Speed of Thought: Proving the Existence of Gravitational Waves

    Science.gov (United States)

    Kennefick, Daniel

    2007-04-01

    Gravitational Waves represent a nearly unique instance of unfinished business in the history of modern physics. One of the slew of novel concepts which arose in the revolutionary period of the early 20th century, they retained their place in the new physics for nearly a century in the total absence of any kind of experimental confirmation. It was only natural, therefore, that their theoretical development was marked by repeated debate over whether they really existed, or played any kind of role in astrophysical systems such as binary stars. The course of these controversies (including the quadrupole formula controversy) is briefly recounted, and it is argued that both confidence in and skepticism of their existence were nourished by the nature of the analogy with electromagnetic waves which enabled their conceptualization in the first place.

  3. A new approach to the theory of heat conduction with finite wave speeds

    Directory of Open Access Journals (Sweden)

    Vito Antonio Cimmelli

    1991-05-01

    Full Text Available Relations between the physical models describing the heat conduction in solids and a phenomenological model leading to quasi-linear hyperbolic equations and systems of conservation laws are presented. A new semi-empirical temperature scale is introduced in terms of which a modified Fourier law is formulated. The hyperbolicity of the heat conduction equation is discussed together with some wave propagation problems.

  4. Propagation properties of Rossby waves for latitudinal β-plane variations of f and zonal variations of the shallow water speed

    Directory of Open Access Journals (Sweden)

    C. T. Duba

    2012-05-01

    Full Text Available Using the shallow water equations for a rotating layer of fluid, the wave and dispersion equations for Rossby waves are developed for the cases of both the standard β-plane approximation for the latitudinal variation of the Coriolis parameter f and a zonal variation of the shallow water speed. It is well known that the wave normal diagram for the standard (mid-latitude Rossby wave on a β-plane is a circle in wave number (ky,kx space, whose centre is displaced −β/2 ω units along the negative kx axis, and whose radius is less than this displacement, which means that phase propagation is entirely westward. This form of anisotropy (arising from the latitudinal y variation of f, combined with the highly dispersive nature of the wave, gives rise to a group velocity diagram which permits eastward as well as westward propagation. It is shown that the group velocity diagram is an ellipse, whose centre is displaced westward, and whose major and minor axes give the maximum westward, eastward and northward (southward group speeds as functions of the frequency and a parameter m which measures the ratio of the low frequency-long wavelength Rossby wave speed to the shallow water speed. We believe these properties of group velocity diagram have not been elucidated in this way before. We present a similar derivation of the wave normal diagram and its associated group velocity curve for the case of a zonal (x variation of the shallow water speed, which may arise when the depth of an ocean varies zonally from a continental shelf.

  5. A high-speed congenic strategy using first-wave male germ cells.

    Directory of Open Access Journals (Sweden)

    Narumi Ogonuki

    Full Text Available BACKGROUND: In laboratory mice and rats, congenic breeding is essential for analyzing the genes of interest on specific genetic backgrounds and for analyzing quantitative trait loci. However, in theory it takes about 3-4 years to achieve a strain carrying about 99% of the recipient genome at the tenth backcrossing (N10. Even with marker-assisted selection, the so-called 'speed congenic strategy', it takes more than a year at N4 or N5. METHODOLOGY/PRINCIPAL FINDINGS: Here we describe a new high-speed congenic system using round spermatids retrieved from immature males (22-25 days of age. We applied the technique to three genetically modified strains of mice: transgenic (TG, knockin (KI and N-ethyl-N-nitrosourea (ENU-induced mutants. The donor mice had mixed genetic backgrounds of C57BL/6 (B6:DBA/2 or B6:129 strains. At each generation, males used for backcrossing were selected based on polymorphic marker analysis and their round spermatids were injected into B6 strain oocytes. Backcrossing was repeated until N4 or N5. For the TG and ENU-mutant strains, the N5 generation was achieved on days 188 and 190 and the proportion of B6-homozygous loci was 100% (74 markers and 97.7% (172/176 markers, respectively. For the KI strain, N4 was achieved on day 151, all the 86 markers being B6-homozygous as early as on day 106 at N3. The carrier males at the final generation were all fertile and propagated the modified genes. Thus, three congenic strains were established through rapid generation turnover between 41 and 44 days. CONCLUSIONS/SIGNIFICANCE: This new high-speed breeding strategy enables us to produce congenic strains within about half a year. It should provide the fastest protocol for precise definition of the phenotypic effects of genes of interest on desired genetic backgrounds.

  6. A high-speed congenic strategy using first-wave male germ cells.

    Science.gov (United States)

    Ogonuki, Narumi; Inoue, Kimiko; Hirose, Michiko; Miura, Ikuo; Mochida, Keiji; Sato, Takahiro; Mise, Nathan; Mekada, Kazuyuki; Yoshiki, Atsushi; Abe, Kuniya; Kurihara, Hiroki; Wakana, Shigeharu; Ogura, Atsuo

    2009-01-01

    In laboratory mice and rats, congenic breeding is essential for analyzing the genes of interest on specific genetic backgrounds and for analyzing quantitative trait loci. However, in theory it takes about 3-4 years to achieve a strain carrying about 99% of the recipient genome at the tenth backcrossing (N10). Even with marker-assisted selection, the so-called 'speed congenic strategy', it takes more than a year at N4 or N5. Here we describe a new high-speed congenic system using round spermatids retrieved from immature males (22-25 days of age). We applied the technique to three genetically modified strains of mice: transgenic (TG), knockin (KI) and N-ethyl-N-nitrosourea (ENU)-induced mutants. The donor mice had mixed genetic backgrounds of C57BL/6 (B6):DBA/2 or B6:129 strains. At each generation, males used for backcrossing were selected based on polymorphic marker analysis and their round spermatids were injected into B6 strain oocytes. Backcrossing was repeated until N4 or N5. For the TG and ENU-mutant strains, the N5 generation was achieved on days 188 and 190 and the proportion of B6-homozygous loci was 100% (74 markers) and 97.7% (172/176 markers), respectively. For the KI strain, N4 was achieved on day 151, all the 86 markers being B6-homozygous as early as on day 106 at N3. The carrier males at the final generation were all fertile and propagated the modified genes. Thus, three congenic strains were established through rapid generation turnover between 41 and 44 days. This new high-speed breeding strategy enables us to produce congenic strains within about half a year. It should provide the fastest protocol for precise definition of the phenotypic effects of genes of interest on desired genetic backgrounds.

  7. High-speed Brillouin imaging via continuous-wave stimulated Brillouin scattering (Conference Presentation)

    Science.gov (United States)

    Remer, Itay; Bilenca, Alberto

    2017-02-01

    Brillouin spectroscopy is a noncontact technique for characterizing the mechanical properties of materials. Typically, Brillouin spectrometers have been realized using scanning Fabry-Perot spectrometers that measure, with long acquisition times, spontaneous Brillouin scattering from the samples. In the last few years, the use of virtually imaged phase array (VIPA) etalons for constructing Brillouin spectrometers has enabled to acquire spontaneous Brillouin spectra times. We will show that this improvement, combined with micrometer-step-size spatial scanning of the sample, provides precise Brillouin profiles of layered liquids at 30-milliseconds pixel-dwell-time, facilitating Brillouin profilometry analysis of materials at high speed.

  8. Superficial Ultrasound Shear Wave Speed Measurements in Soft and Hard Elasticity Phantoms: Repeatability and Reproducibility Using Two Different Ultrasound Systems

    Science.gov (United States)

    Dillman, Jonathan R.; Chen, Shigao; Davenport, Matthew S.; Zhao, Heng; Urban, Matthew W.; Song, Pengfei; Watcharotone, Kuanwong; Carson, Paul L.

    2014-01-01

    Background There is a paucity of data available regarding the repeatability and reproducibility of superficial shear wave speed (SWS) measurements at imaging depths relevant to the pediatric population. Purpose To assess the repeatability and reproducibility of superficial shear wave speed (SWS) measurements acquired from elasticity phantoms at varying imaging depths using three different imaging methods, two different ultrasound systems, and multiple operators. Methods and Materials Soft and hard elasticity phantoms manufactured by Computerized Imaging Reference Systems, Inc. (Norfolk, VA) were utilized for our investigation. Institution #1 used an Acuson S3000 ultrasound system (Siemens Medical Solutions USA, Inc.) and three different shear wave imaging method/transducer combinations, while institution #2 used an Aixplorer ultrasound system (Supersonic Imagine) and two different transducers. Ten stiffness measurements were acquired from each phantom at three depths (1.0, 2.5, and 4.0 cm) by four operators at each institution. Student’s t-test was used to compare SWS measurements between imaging techniques, while SWS measurement agreement was assessed with two-way random effects single measure intra-class correlation coefficients and coefficients of variation. Mixed model regression analysis determined the effect of predictor variables on SWS measurements. Results For the soft phantom, the average of mean SWS measurements across the various imaging methods and depths was 0.84 ± 0.04 m/s (mean ± standard deviation) for the Acuson S3000 system and 0.90 ± 0.02 m/s for the Aixplorer system (p=0.003). For the hard phantom, the average of mean SWS measurements across the various imaging methods and depths was 2.14 ± 0.08 m/s for the Acuson S3000 system and 2.07 ± 0.03 m/s Aixplorer system (p>0.05). The coefficients of variation were low (0.5–6.8%), and inter-operator agreement was near-perfect (ICCs ≥0.99). Shear wave imaging method and imaging depth

  9. mm-Wave Hybrid Photonic Wireless Links for Ultra-High Speed Wireless Transmissions

    DEFF Research Database (Denmark)

    Rommel, Simon; Vegas Olmos, Juan José; Tafur Monroy, Idelfonso

    Hybrid photonic-wireless transmission schemes in the mm-wave frequency range are promising candidates to enable the multi-gigabit per second data communications required from wireless and mobile networks of the 5th and future generations. Large FCC spectrum allocations for wireless transmission...... at 71–76GHz and 81–86GHz allow high-bandwidth, long and medium distance point-to-point links. Photonic integration may pave the way to practical applicability of such hybrid links by reduction in complexity, size and – most important – cost....

  10. Novootkriveni autograf Filipa de Diversija iz 1455. godine: poslanice sv. Jeronima, sv. Augustina i drugih

    OpenAIRE

    Janeković-Römer, Zdenka

    2010-01-01

    Novotkriveni autograf Filipa de Diversi, kodeks u koji je prepisivao poslanice Sv. Jeronima, Sv. Augustina i drugih, donosi važne nove biografske i bibliografske podatke o njemu. Saznajemo da je 1455. godine još bio živ i boravio u Veneciji. Obiman kodeks (278 folija) sačuvan je u knjižnici earla od Leicestera, Holkham Hall u Engleskoj. Članak donosi popis svih poslanica prepisanih u kodeks, s bibliografskim podacima.

  11. Bed Evolution under Rapidly Varying Flows by a New Method for Wave Speed Estimation

    Directory of Open Access Journals (Sweden)

    Khawar Rehman

    2016-05-01

    Full Text Available This paper proposes a sediment-transport model based on coupled Saint-Venant and Exner equations. A finite volume method of Godunov type with predictor-corrector steps is used to solve a set of coupled equations. An efficient combination of approximate Riemann solvers is proposed to compute fluxes associated with sediment-laden flow. In addition, a new method is proposed for computing the water depth and velocity values along the shear wave. This method ensures smooth solutions, even for flows with high discontinuities, and on domains with highly distorted grids. The numerical model is tested for channel aggradation on a sloping bottom, dam-break cases at flume-scale and reach-scale with flat bottom configurations and varying downstream water depths. The proposed model is tested for predicting the position of hydraulic jump, wave front propagation, and for predicting magnitude of bed erosion. The comparison between results based on the proposed scheme and analytical, experimental, and published numerical results shows good agreement. Sensitivity analysis shows that the model is computationally efficient and virtually independent of mesh refinement.

  12. High-speed helicopter rotor noise - Shock waves as a potent source of sound

    Science.gov (United States)

    Farassat, F.; Lee, Yung-Jang; Tadghighi, H.; Holz, R.

    1991-01-01

    In this paper we discuss the problem of high speed rotor noise prediction. In particular, we propose that from the point of view of the acoustic analogy, shocks around rotating blades are sources of sound. We show that, although for a wing at uniform steady rectilinear motion with shocks the volume quadrupole and shock sources cancel in the far field to the order of 1/r, this cannot happen for rotating blades. In this case, some cancellation between volume quadrupoles and shock sources occurs, yet the remaining shock noise contribution is still potent. A formula for shock noise prediction is presented based on mapping the deformable shock surface to a time independent region. The resulting equation is similar to Formulation 1A of Langley. Shock noise prediction for a hovering model rotor for which experimental noise data exist is presented. The comparison of measured and predicted acoustic data shows good agreement.

  13. High-speed landslide mechanism extracted from long-period surface waves

    Science.gov (United States)

    Zhao, J.; Yu, H.; Mangeney, A.; Stutzmann, E.

    2013-12-01

    Long-period seismic signals gathered at stations far from the landslide source can be used to recover the characteristics of the event. Source mechanism inversion based on the surface waves had already been done on two large volcanic debris avalanches (Montserrat, Lesser Antilles 1997 and Mount St. Helens, USA 1980), the initial flow direction, the total volume and the mean slope of the topography had been successfully extracted. We here try to apply the method to two other landslide events, our objective is to refine the source model used in the inversion, and to improve the method for a wider application. The first event is a huge landslide occurred in Yigong Bomi district (30.22N, 94.99E) in Tibet province of China on 9 April 2000. This landslide began as a sliding mass started to fall at the elevation of 5500m, when colliding with the ground, it broke up into debris, and ran for long distance. The whole process lasted about 10 minutes, about 300 million cube meters deposit formed a 60m-high dam in the Yigong river at the elevation of 2190m. The other event is the sudden failure happened at Qianjiangping village (30.97N, 110.61E) on 13 July 2003, on the bank of the Qinggan river. It is the biggest landslide in the last 20 years in the Three Gorges Reservoir area. The landslide flow brought about 20 million cube meters rock and soil masses right into the Qinggan river in a short time with a maximum sliding velocity of about 16m/s. It is a typical rocky-bedding slide, which has been compared to the 1963 Vaiont landslide in Italy. Seismic waves generated by these two events have been recorded respectively by more than 3 seismic stations from China Earthquake Networks (CEN), in the distance range between 360km and 1700km from the landslide source. We use a source model with impulse forces, derived from the schematic view of the mass traveling down the slope.We also perform waveform inversion and compare the result with the force model. The two landslides are

  14. Optical coherence elastography based on high speed imaging of single-hot laser-induced acoustic waves at 16 kHz frame rate

    Science.gov (United States)

    Song, Shaozhen; Hsieh, Bao-Yu; Wei, Wei; Shen, Tueng; Pelivanov, Ivan; O'Donnell, Matthew; Wang, Ruikang K.

    2016-03-01

    Shear wave OCE (SW-OCE) is a novel technique that relies on the detection of the localized shear wave speed to map tissue elasticity. In this study, we demonstrate high speed imaging to capture single-shot transient shear wave propagation for SW-OCE. The fast imaging speed is achieved using a Fourier domain mode-locked (FDML) high-speed swept-source OCT (SS-OCT) system. The frame rate of shear wave imaging is 16 kHz, at an A-line rate of ~1.62 MHz, enabling the detection of high-frequency shear waves up to 8 kHz in bandwidth. Several measures are taken to improve the phase-stability of the SS-OCT system, and the measured displacement sensitivity is ~10 nanometers. To facilitate non-contact elastography, shear waves are generated with the photo-thermal effect using an ultra-violet pulsed laser. High frequency shear waves launched by the pulsed laser contain shorter wavelengths and carry rich localized elasticity information. Benefiting from single-shot acquisition, each SWI scan only takes 2.5 milliseconds, and the reconstruction of the elastogram can be performed in real-time with ~20 Hz refresh rate. SW-OCE measurements are demonstrated on porcine cornea ex vivo. This study is the first demonstration of an all-optical method to perform real-time 3D SW-OCE. It is hoped that this technique will be applicable in the clinic to obtain high-resolution localized quantitative measurements of tissue biomechanical properties.

  15. Families of exact solutions for linear and nonlinear wave equations with a variable speed of sound and their use in solving initial boundary value problems

    Science.gov (United States)

    Trifonov, E. V.

    2017-07-01

    We propose a procedure for multiplying solutions of linear and nonlinear one-dimensional wave equations, where the speed of sound can be an arbitrary function of one variable. We obtain exact solutions. We show that the functional series comprising these solutions can be used to solve initial boundary value problems. For this, we introduce a special scalar product.

  16. Laboratory Measurement of Compressional and Shear Wave Speed in Polycrystalline sI and sII Gas Hydrates and Ice as Functions of Temperature and Pressure

    Science.gov (United States)

    Helgerud, M. B.; Waite, W. F.; Kirby, S. H.; Nur, A.

    2001-12-01

    We report on laboratory measurements of compressional and shear wave speeds in compacted, polycrystalline sI methane and sII methane-ethane hydrates and ice Ih. The hydrate samples were made from granulated ice warmed to 290 K in the presence of methane or methane-ethane gas at high pressure. The resulting porous gas hydrate samples were uniaxially compacted within the synthesis pressure vessel using a hydraulic ram with a moving piston and fixed end plug fitted with shear transducers. Once the samples were fully compacted, the temperature was cycled in steps from 258 to 288 K while the uniaxial pressure was held constant at 60 MPa. After temperature cycling was completed, the uniaxial pressure was varied between 30 and 90 MPa at 283, 273, 263 and 253 K. At the end of each experiment, the uniaxial pressure was slowly decreased to 1 atm at 253 K. Shear and compressional wave speed measurements were made throughout each experiment. For ice Ih, the sample was evacuated before compaction, the measurement temperature range was 253 to 268 K and the applied uniaxial pressure did not exceed 42 MPa. Analysis of the data produces several interesting observations. Among them are: 1) sI and sII gas hydrate resist compaction much more than ice. A pressure of 42 MPa fully compacted the ice sample at 268 K, but a pressure of 105 MPa had to be applied for several days (at temperatures of 253, 278 and 288 K) to fully compact the hydrate samples. 2) Wave speed increases at constant sample length strongly suggest grain to grain bonds form between adjacent ice or gas hydrate grains. The relative wave speed increases with time show this process is more efficient in ice samples, perhaps due to the higher mobility of water in ice's crystal lattice. 3) Within the pressure and temperature conditions studied, the wave speed based calculations of Poisson's ratio are 5 to 6% smaller in sI and sII gas hydrate than in ice. 4) Shear wave speed decreases with increasing uniaxial pressure in Ice

  17. Characteristics of pressure wave in common rail fuel injection system of high-speed direct injection diesel engines

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Herfatmanesh

    2016-05-01

    Full Text Available The latest generation of high-pressure common rail equipment now provides diesel engines possibility to apply as many as eight separate injection pulses within the engine cycle for reducing emissions and for smoothing combustion. With these complicated injection arrangements, optimizations of operating parameters for various driving conditions are considerably difficult, particularly when integrating fuel injection parameters with other operating parameters such as exhaust gas recirculation rate and boost pressure together for evaluating calibration results. Understanding the detailed effects of fuel injection parameters upon combustion characteristics and emission formation is therefore particularly critical. In this article, the results and discussion of experimental investigations on a high-speed direct injection light-duty diesel engine test bed are presented for evaluating and analyzing the effects of main adjustable parameters of the fuel injection system on all regulated emission gases and torque performance. Main injection timing, rail pressure, pilot amount, and particularly pilot timing have been examined. The results show that optimization of each of those adjustable parameters is beneficial for emission reduction and torque improvement under different operating conditions. By exploring the variation in the interval between the pilot injection and the main injection, it is found that the pressure wave in the common rail has a significant influence on the subsequent injection. This suggests that special attentions must be paid for adjusting pilot timing or any injection interval when multi-injection is used. With analyzing the fuel amount oscillation of the subsequent injections to pilot separation, it demonstrates that the frequency of regular oscillations of the actual fuel amount or the injection pulse width with the variation in pilot separation is always the same for a specified fuel injection system, regardless of engine speed

  18. Numerical investigation on an array of Helmholtz resonators for the reduction of micro-pressure waves in modern and future high-speed rail tunnel systems

    Science.gov (United States)

    Tebbutt, J. A.; Vahdati, M.; Carolan, D.; Dear, J. P.

    2017-07-01

    Previous research has proposed that an array of Helmholtz resonators may be an effective method for suppressing the propagation of pressure and sound waves, generated by a high-speed train entering and moving in a tunnel. The array can be used to counteract environmental noise from tunnel portals and also the emergence of a shock wave in the tunnel. The implementation of an array of Helmholtz resonators in current and future high-speed train-tunnel systems is studied. Wave propagation in the tunnel is modelled using a quasi-one-dimensional formulation, accounting for non-linear effects, wall friction and the diffusivity of sound. A multi-objective genetic algorithm is then used to optimise the design of the array, subject to the geometric constraints of a demonstrative tunnel system and the incident wavefront in order to attenuate the propagation of pressure waves. It is shown that an array of Helmholtz resonators can be an effective countermeasure for various tunnel lengths. In addition, the array can be designed to function effectively over a wide operating envelope, ensuring it will still function effectively as train speeds increase into the future.

  19. The propagation of detonation waves in non-ideal condensed-phase explosives confined by high sound-speed materials

    Science.gov (United States)

    Schoch, Stefan; Nikiforakis, Nikolaos; Lee, Bok Jik

    2013-08-01

    Highly non-ideal condensed-phase explosives used by the mining industry have a strong detonation velocity dependence on the charge dimension. Detonation velocities can be as low as one third of the theoretically calculated ideal detonation velocity in charge radii close to the failure radius. Under these detonation conditions the flow in the confiner can become subsonic, a flow condition under which classical shock-polar analysis is not applicable. This restriction prohibits the use of popular engineering models like detonation shock dynamics and Wood-Kirkwood type models under these confinement conditions. In addition, it has been found in the literature that subsonic flow in the confiner will increase the influence of the confining material on the detonation performance. In this work, we use a multi-phase model coupled to an elastic-plastic model (for the representation of a confiner) to explore the interaction of detonations under these confiner conditions. An ammonium nitrate based mining emulsion is investigated in aluminium and steel confinement of finite and infinite thickness representing the confiner as either a fluid or an elastic-plastic material. It is found that the presence of elastic waves is negligible close to ideal detonation conditions, but is important close to the failure radius and in detonation conditions with subsonic flow in the confiner. High sound-speed confiners support the detonation through energy transport ahead of the detonation front if desensitisation effects are negligible. The detonation front profiles are found to remain convex even in the most non-ideal detonation conditions, and the detonation front curvature only becomes concave in a localised region close to the confiner edge.

  20. Speed evolution of fast CME/shocks with SOHO/LASCO, WIND/WAVES, IPS and in-situ WIND data: analysis of kilometric type-II emissions

    Directory of Open Access Journals (Sweden)

    A. Gonzalez-Esparza

    2009-10-01

    Full Text Available Fast CME/shocks propagating in the interplanetary medium can generate kilometric Type II (km-TII radio emissions at the local plasma frequency and/or its harmonic, so these radio emissions provide a means of remotely tracking CME/shocks. We apply a new analysis technique, using the frequency drift of km-TII spectrum obtained by the Thermal Noise Receiver (TNR of the WIND/WAVES experiment, to infer, at some adequate intervals, the propagation speed of six CME/shocks. We combine these results with previously reported speeds from coronagraph white light and interplanetary scintillation observations, and in-situ measurements, to study the temporal speed evolution of the six events. The speed values obtained by the km-TII analysis are in a reasonable agreement with the speed measurements obtained by other techniques at different heliocentric distance ranges. The combination of all the speed measurements show a gradual deceleration of the CME/shocks as they propagate to 1 AU. This new technique can be useful in studying the evolution of fast CME/shocks when adequate intervals of km-TII emissions are available.

  1. Efficient prediction methods for the micro-pressure wave from a high-speed train entering a tunnel using the Kirchhoff formulation.

    Science.gov (United States)

    Yoon, T; Lee, S

    2001-11-01

    The compression wave generated by a high-speed train emerging from the exit portal of a tunnel gives rise to an impulsive noise called a micro-pressure wave. In this study, new methods for the prediction of sonic-boom noise are proposed. The first method combines acoustic monopole analysis and the method of characteristics with the Kirchhoff method. The compression wave from a train entering a tunnel is calculated by an approximate compact Green's function, and the resultant noise at the tunnel exit is predicted by a linear Kirchhoff formulation. The second method couples the Kirchhoff formulation with the Euler equation, which is solved numerically for the generation and propagation of the compression wave. Numerical prediction of the compression wave, the propagation in the tunnel, and the micro-pressure wave obtained by the present methods are compared with measured data. The numerical results exhibit a reasonable agreement with the experimental data. The proposed methods in this study are shown to be very useful design tools for the nose shape of trains and the geometry of tunnels, and they can be utilized to minimize the pressure fluctuation in the tunnel and the corresponding booming noise.

  2. Modeling Regional Seismic Waves

    Science.gov (United States)

    1991-03-25

    Shear waves are almost always observed from underground explosions. One can visualize many ways to convert explosion P waves into SV waves. An ob- vious...of the observed moment to the input source moment, Moba /Mo, as a function of the compressional velocities a, of the embedded sphere for different whole

  3. The diagnostic performance of shear wave speed (SWS) imaging for thyroid nodules with elasticity modulus and SWS measurement.

    Science.gov (United States)

    Wang, Dan; He, Ya-Ping; Zhang, Yi-Feng; Liu, Bo-Ji; Zhao, Chong-Ke; Fu, Hui-Jun; Wei, Qing; Xu, Hui-Xiong

    2017-02-21

    To evaluate the diagnostic performance of a new technique of shear wave speed (SWS) imaging for the diagnosis of thyroid nodule with elasticity modulus and SWS measurement. 322 thyroid nodules in 322 patients (216 benign nodules, 106 malignant nodules) were included in this study. All the nodules received conventional ultrasound (US) and SWS imaging (Aplio500, Toshiba Medical Systems, Japan) before fine-needle aspiration (FNA) and/or surgery. The values of E-max and E-mean with elastic modulus (61.27 ± 36.31 kPa and 31.89 ± 19.11 kPa) or SWS (4.45 ± 1.49 m/s and 3.26 ± 2.71 m/s) in malignant nodules were significantly higher than those in benign lesions (29.18 ± 18.62 kPa and 15.85 ± 6.96 kPa, or 2.98 ± 0.85 m/s and 2.19 ± 0.42 m/s, all P 0.05). In multivariate logistic regression analysis, E-max (m/s) with SWS was identified to be the strongest independent predictor for malignant nodules (odds ratio [OR] = 16.760), followed by poorly-defined margin (OR = 7.792), taller-than-wide shape (OR = 3.160), micro-calcification (OR = 2.422), and E-max (kPa) with elastic modulus (OR = 0.914). The AUC was 0.813 for E-max with SWS (m/s) and 0.796 for E-max with elastic modulus (kPa). With cut-off SWS value of 3.52 m/s in E-max, sensitivity of 69.8%, specificity of 81.5%, and accuracy of 77.6% were achieved. SWS imaging is a valuable tool in predicting thyroid malignancy. E-max with SWS measurement is the strongest independent predictor for thyroid malignancy.

  4. The Use of Shock Isolation mounts in Small High-Speed Craft to Protect Equipment from Wave Slam Effects

    Science.gov (United States)

    2017-07-01

    including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services , Directorate for Information Operations and... failure during high-speed operations in rough seas is discussed. 15. SUBJECT TERMS Shock mounts planing craft equipment data...shock isolation systems. An alternative method for minimizing the risk of equipment failure during high-speed operations in rough seas is discussed

  5. Sensitivity of the quasi-biennial oscillation simulated in WACCM to the phase speed spectrum and the settings in an inertial gravity wave parameterization

    Science.gov (United States)

    Yu, Chao; Xue, Xianghui; Wu, Jianfei; Chen, Tingdi; Li, Huimin

    2017-03-01

    The application of inertial gravity wave parameterization has allowed for the spontaneous generation of quasi-biennial oscillation (QBO) in the Whole Atmosphere Community Climate Model (WACCM), although there is some mismatch when comparing with observations. The parameterization is based on Lindzen's linear saturation theory, modified to describe inertia-gravity waves (IGW) by considering the Coriolis effect. In this work, we improve the parameterization by importing a more realistic IGW phase speed spectrum that exhibits a double peak Gaussian distribution calculated from tropical radiosonde observations. A series of numeric simulations are performed to test the sensitivity of QBO-like oscillation features to the phase speed spectrum and the settings of parameterized IGW. All these simulations are capable of generating equatorial wind oscillations in the stratosphere based on standard spatial resolution settings. Central phase speeds of the "double-Gaussian parameterization" affect QBO magnitudes and periods, and the momentum flux of IGW determines the acceleration rate of zonal wind. Furthermore, stronger IGW forcing can lead to a propagation of the QBO-like oscillation to lower altitude. The intermittency factor of the parameterization also prominently affects the QBO period. Stratospheric QBO-like oscillation with obvious improvements is generated using the new IGW parameterization in a long-time simulation.

  6. Comments on ‘Temporal significant wave height estimation from wind speed by perceptron Kalman filtering’ by A. Altunkaynak and M. Ozger, Ocean Engineering, Vol. 31(10); 2004,1245-1255

    Digital Repository Service at National Institute of Oceanography (India)

    Mandal, S.

    significant wave height estimation from wind speed by perceptron Kalman filtering? by A Altunkaynak and M Ozger, Ocean Engineering, 2004, 31, 1245-1255 Discussion by S Mandal* Ocean Engineering Division, National Institute of Oceanography, Dona Paula... of neural network in the study of wave transformation. REFERENCES Deo, M.C. and Naidu, C.S., 1999. Real time wave forecasting using neural networks. Ocean Engineering, 26, 191-203. Mandal, S and Prabaharan, N, 2003. An overview of the numerical...

  7. Strategic Control of 60 GHz Millimeter-Wave High-Speed Wireless Links for Distributed Virtual Reality Platforms

    Directory of Open Access Journals (Sweden)

    Joongheon Kim

    2017-01-01

    Full Text Available This paper discusses the stochastic and strategic control of 60 GHz millimeter-wave (mmWave wireless transmission for distributed and mobile virtual reality (VR applications. In VR scenarios, establishing wireless connection between VR data-center (called VR server (VRS and head-mounted VR device (called VRD allows various mobile services. Consequently, utilizing wireless technologies is obviously beneficial in VR applications. In order to transmit massive VR data, the 60 GHz mmWave wireless technology is considered in this research. However, transmitting the maximum amount of data introduces maximum power consumption in transceivers. Therefore, this paper proposes a dynamic/adaptive algorithm that can control the power allocation in the 60 GHz mmWave transceivers. The proposed algorithm dynamically controls the power allocation in order to achieve time-average energy-efficiency for VR data transmission over 60 GHz mmWave channels while preserving queue stabilization. The simulation results show that the proposed algorithm presents desired performance.

  8. Fast estimation from above of the maximum wave speed in the Riemann problem for the Euler equations

    Science.gov (United States)

    Guermond, Jean-Luc; Popov, Bojan

    2016-09-01

    This paper is concerned with the construction of a fast algorithm for computing the maximum speed of propagation in the Riemann solution for the Euler system of gas dynamics with the co-volume equation of state. The novelty in the algorithm is that it stops when a guaranteed upper bound for the maximum speed is reached with a prescribed accuracy. The convergence rate of the algorithm is cubic and the bound is guaranteed for gasses with the co-volume equation of state and the heat capacity ratio γ in the range (1 , 5 / 3 ].

  9. Scattering and diffraction of plane P-waves in a 2-D elastic half-space II: shallow arbitrary shaped canyon

    Science.gov (United States)

    Brandow, Heather P.; Lee, Vincent

    2017-07-01

    Scattering and Diffraction of elastic in-plane P- and SV- waves by a surface topography such as an elastic canyon at the surface of a half-space is a classical problem which has been studied by earthquake engineers and strong-motion seismologists for over forty years. The case of out-of-plane SH waves on the same elastic canyon that is semi-circular in shape on the half-space surface is the first such problem that was solved by analytic closed form solutions over forty years ago by Trifunac. The corresponding case of in-plane P- and SV-waves on the same circular canyon is a much more complicated problem because, the in-plane P- and SV- scattered waves have different wave speeds and together they must have zero normal and shear stresses at the half-space surface. It is not until recently in 2014 that analytic solution for such problem is found by the author in the work of Lee and Liu. This paper uses the technique of Lee and Liu of defining these stress-free scattered waves to solve the problem of the scattered and diffraction of these in-plane waves on an almost-circular surface canyon that is arbitrary in shape.

  10. Wave

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo

    2008-01-01

    Estimates for the amount of potential wave energy in the world range from 1-10 TW. The World Energy Council estimates that a potential 2TW of energy is available from the world’s oceans, which is the equivalent of twice the world’s electricity production. Whilst the recoverable resource is many...... times smaller it remains very high. For example, whilst there is enough potential wave power off the UK to supply the electricity demands several times over, the economically recoverable resource for the UK is estimated at 25% of current demand; a lot less, but a very substantial amount nonetheless....

  11. Plane Wave-Perturbative Method for Evaluating the Effective Speed of Sound in 1D Phononic Crystals

    Directory of Open Access Journals (Sweden)

    J. Flores Méndez

    2016-01-01

    Full Text Available A method for calculating the effective sound velocities for a 1D phononic crystal is presented; it is valid when the lattice constant is much smaller than the acoustic wave length; therefore, the periodic medium could be regarded as a homogeneous one. The method is based on the expansion of the displacements field into plane waves, satisfying the Bloch theorem. The expansion allows us to obtain a wave equation for the amplitude of the macroscopic displacements field. From the form of this equation we identify the effective parameters, namely, the effective sound velocities for the transverse and longitudinal macroscopic displacements in the homogenized 1D phononic crystal. As a result, the explicit expressions for the effective sound velocities in terms of the parameters of isotropic inclusions in the unit cell are obtained: mass density and elastic moduli. These expressions are used for studying the dependence of the effective, transverse and longitudinal, sound velocities for a binary 1D phononic crystal upon the inclusion filling fraction. A particular case is presented for 1D phononic crystals composed of W-Al and Polyethylene-Si, extending for a case solid-fluid.

  12. Transgenic Mouse Models of SV40-Induced Cancer.

    Science.gov (United States)

    Hudson, Amanda L; Colvin, Emily K

    2016-01-01

    The SV40 viral oncogene has been used since the 1970s as a reliable and reproducible method to generate transgenic mouse models. This seminal discovery has taught us an immense amount about how tumorigenesis occurs, and its success has led to the evolution of many mouse models of cancer. Despite the development of more modern and targeted approaches for developing genetically engineered mouse models of cancer, SV40-induced mouse models still remain frequently used today. This review discusses a number of cancer types in which SV40 mouse models of cancer have been developed and highlights their relevance and importance to preclinical research. © The Author 2016. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  13. Cyclic variations of the period and luminosity of SV Camelopardalis

    Science.gov (United States)

    Manzoori, D.

    2016-06-01

    New standardized V-band light curves (LCs) for the eclipsing binary SV Cam have been modeled using the PHOEBE program (v. 0.31a). Absolute parameters of the stellar components were then determined, enabling them to be positioned on the mass-radius diagram. Analysis of eclipse minima timing data (O-C diagrams) indicated two cyclic periods of 48.0 and 23.3 yr. These cyclic variations of the orbital period are interpreted in terms of motion of a third body around the system and magnetic activity cycle modulating the orbital period of SV Cam via the Applegate (1992) mechanism. The use of the Applegate model for SV Cam has been checked by examining the long term brightness variation and calculating some important parameters of this system. The results of these calculations favor the modulation of the orbital period by the Applegate mechanism.

  14. A study on breaking wind waves with white caps by means of Visualization with high—speed video cameras

    OpenAIRE

    竹原, 幸生; 江藤, 剛治; 鈴木, 直弥; 高野, 保英; 森, 信人; 水谷, 夏樹; Sigurdur, T. Thoroddsen

    2010-01-01

    研究成果の概要(和文): 大気一海洋間の気体輸送現象に対するホワイトキャップの影響を明らかにするため, 3台の高速ビデオカメラを用いた画像計測法により, 風波界面近傍の流れ場計測技術を開発し, ホワイトキャップが生じている近傍の流れ場を明らかにした.さらに, 気流と風波発達の関係も画像計測により明らかにした. また, 砕波により生じた気泡の特性を画像計測により明らかにした. さらに, 全球規模での大気-海洋間の気体輸送に対する砕波の影響も現地計測データや衛星データを用いて評価した. 研究成果の概要(英文): In order to understand the mechanism of gas-transfer at wind waves with whitecaps,a PTV measurement technique was developed to measure flow fields under wind wave. The measurement technique was applied to flow field under white-cap wh...

  15. Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice.

    Directory of Open Access Journals (Sweden)

    Jia Yao

    Full Text Available Neurons express two families of transporter-like proteins - Synaptic Vesicle protein 2 (SV2A, B, and C and SV2-related proteins (SVOP and SVOPL. Both families share structural similarity with the Major Facilitator (MF family of transporters. SV2 is present in all neurons and endocrine cells, consistent with it playing a key role in regulated exocytosis. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Furthermore, SVOP is expressed earlier in development than SV2 and is one of the neuronal proteins whose expression declines most during aging. Although SV2 is essential for survival, it is not required for development. Because significant levels of neurotransmission remain in the absence of SV2 it has been proposed that SVOP performs a function similar to that of SV2 that mitigates the phenotype of SV2 knockout mice. To test this, we generated SVOP knockout mice and SVOP/SV2A/SV2B triple knockout mice. Mice lacking SVOP are viable, fertile and phenotypically normal. Measures of neurotransmission and behaviors dependent on the cerebellum and pineal gland revealed no measurable phenotype. SVOP/SV2A/SV2B triple knockout mice did not display a phenotype more severe than mice harboring the SV2A/SV2B gene deletions. These findings support the interpretation that SVOP performs a unique, though subtle, function that is not necessary for survival under normal conditions.

  16. ER Operations Installation of Three FLUTe Soil-Vapor Monitoring Wells (MWL-SV03 MWL-SV04 and MWL-SV05) at the Mixed Waste Landfill.

    Energy Technology Data Exchange (ETDEWEB)

    Copland, John Robin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-09-01

    This installation report describes the May through July 2014 drilling activities performed for the installation of three multi-port soil-vapor monitoring wells (MWL-SV03, MWL-SV04, and MWL-SV05) at the Mixed Waste Landfill (MWL), which is located at Sandia National Laboratories, New Mexico (SNL/NM). SNL/NM is managed and operated by Sandia Corporation (Sandia), a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy (DOE)/National Nuclear Security Administration. The MWL is designated as Solid Waste Management Unit (SWMU) 76 and is located in Technical Area (TA) III (Figure 1-1). The locations of the three soil-vapor monitoring wells (MWL-SV03, MWL-SV04, and MWL-SV05) are shown in Figure 1-2

  17. Separate P‐ and SV‐wave equations for VTI media

    KAUST Repository

    Pestana, Reynam C.

    2011-01-01

    In isotropic media we use the scalar acoustic wave equation to perform reverse time migration RTM of the recorded pressure wavefleld data. In anisotropic media P- and SV-waves are coupled and the elastic wave equation should be used for RTM. However, an acoustic anisotropic wave equation is often used instead. This results in significant shear wave energy in both modeling and RTM. To avoid this undesired SV-wave energy, we propose a different approach to separate P- and SV-wave components for vertical transversely isotropic VTI media. We derive independent pseudo-differential wave equations for each mode. The derived equations for P- and SV-waves are stable and reduce to the isotropic case. The equations presented here can be effectively used to model and migrate seismic data in VTI media where ε - δ is small. The SV-wave equation we develop is now well-posed and triplications in the SV wavefront are removed resulting in stable wave propagation. We show modeling and RTM results using the derived pure P-wave mode in complex VTI media and use the rapid expansion method REM to propagate the waveflelds in time. © 2011 Society of Exploration Geophysicists.

  18. Ultrasonic characterization of the nonlinear properties of canine livers by measuring shear wave speed and axial strain with increasing portal venous pressure.

    Science.gov (United States)

    Rotemberg, Veronica; Byram, Brett; Palmeri, Mark; Wang, Michael; Nightingale, Kathryn

    2013-07-26

    Elevated hepatic venous pressure is the primary source of complications in advancing liver disease. Ultrasound imaging is ideal for potential noninvasive hepatic pressure measurements as it is widely used for liver imaging. Specifically, ultrasound based stiffness measures may be useful for clinically monitoring pressure, but the mechanism by which liver stiffness increases with hepatic pressure has not been well characterized. This study is designed to elucidate the nonlinear properties of the liver during pressurization by measuring both hepatic shear wave speed (SWS) and strain with increasing pressure. Tissue deformation during hepatic pressurization was tracked in 8 canine livers using successively acquired 3-D B-mode volumes and compared with concurrently measured SWS. When portal venous pressure was increased from clinically normal (0-5mmHg) to pressures representing highly diseased states at 20mmHg, the liver was observed to expand with axial strain measures up to 10%. At the same time, SWS estimates were observed to increase from 1.5-2m/s at 0-5mmHg (baseline) to 3.25-3.5m/s at 20mmHg. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. Speed selection for traveling-wave solutions to the diffusion-reaction equation with cubic reaction term and Burgers nonlinear convection.

    Science.gov (United States)

    Sabelnikov, V A; Lipatnikov, A N

    2014-09-01

    The problem of traveling wave (TW) speed selection for solutions to a generalized Murray-Burgers-KPP-Fisher parabolic equation with a strictly positive cubic reaction term is considered theoretically and the initial boundary value problem is numerically solved in order to support obtained analytical results. Depending on the magnitude of a parameter inherent in the reaction term (i) the term is either a concave function or a function with the inflection point and (ii) transition from pulled to pushed TW solution occurs due to interplay of two nonlinear terms; the reaction term and the Burgers convection term. Explicit pushed TW solutions are derived. It is shown that physically observable TW solutions, i.e., solutions obtained by solving the initial boundary value problem with a sufficiently steep initial condition, can be determined by seeking the TW solution characterized by the maximum decay rate at its leading edge. In the Appendix, the developed approach is applied to a non-linear diffusion-reaction equation that is widely used to model premixed turbulent combustion.

  20. Shorter intervals at peak SV vs.V̇O2max may yield high SV with less physiological stress.

    Science.gov (United States)

    Colakoglu, Muzaffer; Ozkaya, Ozgur; Balci, Gorkem Aybars; Yapicioglu, Bulent

    2015-01-01

    The purpose of this study was to evaluate whether greater and sustainable stroke volume (SV) responses may be obtained by exercise intensities corresponding to peak SV (SVpeak) vs. maximal O2 consumption (VO2max), and short vs. long intervals (SI vs. LI). Nine moderate- to well-trained male athletes competing at regional level specialists of cyclist, track and field volunteered to take part in the study (VO2max: 59.7 ± 7.4 mL·min(-1)·kg(-1)). Following familiarisation sessions, VO2max was determined, and then SVpeak was evaluated using exercise intensities at 40%-100% of VO2max by nitrous-oxide rebreathing (N2ORB) method. Then each separate participant exercised wattages corresponding to individual VO2max and SVpeak during both SI (SIVO2max and SI(SVpeak)) and LI (LIVO2max and LI(SVpeak)) workouts on a cycle ergometer. Main results showed that both SIVO2max and SI(SVpeak) yielded greater SV responses than LIVO2max and LI(SVpeak) (p ≤ 0.05). Mean SV responses were greater in LI(SVpeak) than in LIVO2max (p ≤ 0.05), but there was no statistical difference between SI(SVpeak) and SIVO2max. However, there was significantly less physiological stress based on VO2, respiratory exchange ratio, heart rate and rate of perceived exhaustion in SVpeak than in [Formula: see text] intensities (p ≤ 0.05). Moreover, SV responses at exercise phases increased in the early stages and remain stable until the end of SIVO2max and SI(SVpeak) workouts (p > 0.05), while they were gradually decreasing in LIVO2max and LI(SVpeak) sessions (p ≤ 0.05). In conclusion, if the aim of a training session is to improve SVpeak with less physiological stress, SI(SVpeak) seems a better alternative than other modalities tested in the present study.

  1. Calculating Speed of Sound

    Science.gov (United States)

    Bhatnagar, Shalabh

    2017-01-01

    Sound is an emerging source of renewable energy but it has some limitations. The main limitation is, the amount of energy that can be extracted from sound is very less and that is because of the velocity of the sound. The velocity of sound changes as per medium. If we could increase the velocity of the sound in a medium we would be probably able to extract more amount of energy from sound and will be able to transfer it at a higher rate. To increase the velocity of sound we should know the speed of sound. If we go by the theory of classic mechanics speed is the distance travelled by a particle divided by time whereas velocity is the displacement of particle divided by time. The speed of sound in dry air at 20 °C (68 °F) is considered to be 343.2 meters per second and it won't be wrong in saying that 342.2 meters is the velocity of sound not the speed as it's the displacement of the sound not the total distance sound wave covered. Sound travels in the form of mechanical wave, so while calculating the speed of sound the whole path of wave should be considered not just the distance traveled by sound. In this paper I would like to focus on calculating the actual speed of sound wave which can help us to extract more energy and make sound travel with faster velocity.

  2. SV40 Assembly In Vivo and In Vitro

    Directory of Open Access Journals (Sweden)

    Ariella Oppenheim

    2008-01-01

    Full Text Available The Simian virus 40 (SV40 capsid is a T = 7d icosahedral lattice ∼45 nm in diameter surrounding the ∼5 kb circular minichromosome. The outer shell is composed of 360 monomers of the major capsid protein VP1, tightly bound in 72 pentamers. VP1 is a jellyroll β-barrel, with extending N- and C-terminal arms. The N-terminal arms bind DNA and face the interior of the capsid. The flexible C-arms tie together the 72 pentamers in three distinct kinds of interactions, thus facilitating the formation of a T = 7 icosahedron from identical pentameric building blocks. Assembly in vivo was shown to occur by addition of capsomers around the DNA. We apply a combination of biochemical and genetic approaches to study SV40 assembly. Our in vivo and in vitro studies suggest the following model: one or two capsomers bind at a high affinity to ses, the viral DNA encapsidation signal, forming the nucleation centre for assembly. Next, multiple capsomers attach concomitantly, at lower affinity, around the minichromosome. This increases their local concentration facilitating rapid, cooperative assembly reaction. Formation of the icosahedron proceeds either by gradual addition of single pentamers to the growing shell or by concerted assembly of pentamer clusters.

  3. Virus-specific nucleic acids in SV40-exposed hamster embryo cell lines: correlation with S and T antigens.

    Science.gov (United States)

    Levin, M J; Oxman, M N; Diamandopoulos, G T; Levine, A S; Henry, P H; Enders, J F

    1969-02-01

    A number of homologous SV40-exposed hamster embryonic cell lines were examined for the presence of RNA complementary to SV40 DNA. Only those lines containing the SV40 T antigen were found to have such virus-specific RNA. In lines containing the SV40 S antigen, but not the SV40 T antigen, virus-specific RNA was not detected. These findings suggest that the S antigen is not coded for directly by the SV40 genome.

  4. VIRUS-SPECIFIC NUCLEIC ACIDS IN SV40-EXPOSED HAMSTER EMBRYO CELL LINES: CORRELATION WITH S AND T ANTIGENS*

    Science.gov (United States)

    Levin, Myron J.; Oxman, Michael N.; Diamandopoulos, George Th.; Levine, Arthur S.; Henry, Patrick H.; Enders, John F.

    1969-01-01

    A number of homologous SV40-exposed hamster embryonic cell lines were examined for the presence of RNA complementary to SV40 DNA. Only those lines containing the SV40 T antigen were found to have such virus-specific RNA. In lines containing the SV40 S antigen, but not the SV40 T antigen, virus-specific RNA was not detected. These findings suggest that the S antigen is not coded for directly by the SV40 genome. PMID:4307716

  5. Levetiracetam reverses synaptic deficits produced by overexpression of SV2A.

    Directory of Open Access Journals (Sweden)

    Amy Nowack

    Full Text Available Levetiracetam is an FDA-approved drug used to treat epilepsy and other disorders of the nervous system. Although it is known that levetiracetam binds the synaptic vesicle protein SV2A, how drug binding affects synaptic functioning remains unknown. Here we report that levetiracetam reverses the effects of excess SV2A in autaptic hippocampal neurons. Expression of an SV2A-EGFP fusion protein produced a ∼1.5-fold increase in synaptic levels of SV2, and resulted in reduced synaptic release probability. The overexpression phenotype parallels that seen in neurons from SV2 knockout mice, which experience severe seizures. Overexpression of SV2A also increased synaptic levels of the calcium-sensor protein synaptotagmin, an SV2-binding protein whose stability and trafficking are regulated by SV2. Treatment with levetiracetam rescued normal neurotransmission and restored normal levels of SV2 and synaptotagmin at the synapse. These results indicate that changes in SV2 expression in either direction impact neurotransmission, and suggest that levetiracetam may modulate SV2 protein interactions.

  6. Biologic properties of viable deletion mutants of simian virus 40 (SV40) rescued from the cells of an SV40-induced hamster lymphocytic leukemia.

    Science.gov (United States)

    Diamandopoulos, G T; Carmichael, G

    1983-12-01

    A lymphocytic leukemia induced by the oncogenic DNA simian virus 40 (SV40) in an inbred LSH/SsLak Syrian golden hamster was evoked to produce infectious SV40 by fusion of the leukemia cells with grivet monkey kidney (GMK) cells and by exposure of the leukemia cells to the chemical inducers mitomycin C and cycloheximide. Plaque-purified viable substrains of the rescued SV40 when studied by restriction endonuclease digestion of viral DNA were found to contain small deletions within the Hind III restriction fragment C. These deletions lay near the viral origin of DNA replication. Ten plaque-purified substrains of the rescued virus identified by immunofluorescence as being SV40 were found, when compared to the wild-type SV40, to replicate slowly and to form small plaques. Although these substrains transformed NIH/3T3 cells as efficiently as the wild-type SV40 in tissue culture, they were generally less oncogenic in vivo--7 of the 10 failed to induce tumors. The 3 oncogenic SV40-rescued substrains were not found to exhibit "lymphocytotropism," i.e., the capacity to infect and neoplastically transform preferentially hamster lymphocytes. Thus the hamster lymphocytic leukemia originally induced by the wild-type SV40 was most likely a chance-stochastic event rather than the result of tropism-determinism mediated by the virus, as is usually the case with leukemogenic RNA viruses.

  7. OPERATIONAL AND MAINTENANCE FEATURES OF THE SV. TRI KRALJA TUNNEL

    Directory of Open Access Journals (Sweden)

    Zvonimir Deković

    2013-12-01

    Full Text Available The paper focuses on the features of the operation and maintenance of tunnels on the Zagreb-Macelj motorway. When it comes to the operation and maintenance of a series of six tunnels on the Zagreb-Macelj motorway, Sv. Tri Kralja Tunnel is the most challenging structure on the motorway, where it is necessary to provide an adequate level of safety and operability. Tunnel operation is ensured by the concession model of public - private partnership, which is applied to the Zagreb – Macelj motorway. Features of the tunnel infrastructure maintenance are emphasized, as well as importance of the extraordinary maintenance of the tunnel infrastructure. The goal of the tunnel operation and maintenance is to ensure undisturbed and safe traffic flow through the tunnels, by keeping the tunnel in normal functional conditions.

  8. A study of the noncollinear ultrasonic-wave-mixing technique under imperfect resonance conditions

    NARCIS (Netherlands)

    Demcenko, A.; Mainini, L.; Korneev, V.A.

    2015-01-01

    Geometrical and material property changes cause deviations in the resonant conditions used for noncollinear wave mixing. These deviations are predicted and observed using the SV(ω1) + L(ω2) → L(ω1 + ω2) interaction, where SV and L are the shear vertical and longitudinal waves, respectively, and ω1,

  9. Polio vaccines, SV40 and human tumours, an update on false positive and false negative results.

    Science.gov (United States)

    Elmishad, A G; Bocchetta, M; Pass, H I; Carbone, M

    2006-01-01

    Simian virus 40 (SV40) has been detected in different human tumours in numerous laboratories. The detection of SV40 in human tumours has been linked to the administration of SV40-contaminated polio vaccines from 1954 until 1963. Many of these reports linked SV40 to human mesothelioma. Some studies have failed to detect SV40 in human tumours and this has caused a controversy. Here we review the current literature. Moreover, we present evidence showing how differences in the sensitivities of methodologies can lead to a very different interpretation of the same study. The same 20 mesothelioma specimens all tested negative, 2/20 tested positive or 7/20 tested positive for SV40 Tag by simply changing the detection method on the same immuno-precipitation/western blot membranes. These results provide a simple explanation for some of the apparent discordant results reported in the literature.

  10. Contribution of the ULF wave activity to the global recovery of the outer radiation belt during the passage of a high-speed solar wind stream observed in September 2014

    Science.gov (United States)

    Dal Lago, A.; Da Silva, L. A.; Alves, L. R.; Dallaqua, R.; Marchezi, J.; Medeiros, C.; Souza, V. M. C. E. S.; Koga, D.; Jauer, P. R.; Vieira, L.; Rockenbach, M.; Mendes, O., Jr.; De Nardin, C. M.; Sibeck, D. G.

    2016-12-01

    The interaction of the solar wind with the Earth's magnetosphere can either increase or decrease the relativistic electron population in the outer radiation belt. In order to investigate the contribution of the ULF wave activity to the global recovery of the outer radiation belt relativistic electron population, we searched the Van Allen data for a period in which we can clearly distinguish the enhancement of the fluxes from the background. The complex solar wind structure observed from September 12-24, 2014, which resulted from the interaction of two coronal mass ejections (CMEs) and a high-speed stream, presented such a scenario. The CMEs are related to the dropout of the relativistic electron population followed by several days of low fluxes. The global recovery started during the passage of the high-speed stream that was associated with the occurrence of substorms that persisted for several days. Here we estimate the contribution of ULF wave-particle interactions to the enhancement of the relativistic electron fluxes. Our approach is based on estimates of the ULF wave radial diffusion coefficients employing two models: (a) an analytic expression presented by Ozeke et al. (2014); and (b) a simplified model based on the solar wind parameters. The preliminary results, uncertainties and future steps are discussed in details.

  11. SV-AUTOPILOT: optimized, automated construction of structural variation discovery and benchmarking pipelines.

    Science.gov (United States)

    Leung, Wai Yi; Marschall, Tobias; Paudel, Yogesh; Falquet, Laurent; Mei, Hailiang; Schönhuth, Alexander; Maoz Moss, Tiffanie Yael

    2015-03-25

    Many tools exist to predict structural variants (SVs), utilizing a variety of algorithms. However, they have largely been developed and tested on human germline or somatic (e.g. cancer) variation. It seems appropriate to exploit this wealth of technology available for humans also for other species. Objectives of this work included: a) Creating an automated, standardized pipeline for SV prediction. b) Identifying the best tool(s) for SV prediction through benchmarking. c) Providing a statistically sound method for merging SV calls. The SV-AUTOPILOT meta-tool platform is an automated pipeline for standardization of SV prediction and SV tool development in paired-end next-generation sequencing (NGS) analysis. SV-AUTOPILOT comes in the form of a virtual machine, which includes all datasets, tools and algorithms presented here. The virtual machine easily allows one to add, replace and update genomes, SV callers and post-processing routines and therefore provides an easy, out-of-the-box environment for complex SV discovery tasks. SV-AUTOPILOT was used to make a direct comparison between 7 popular SV tools on the Arabidopsis thaliana genome using the Landsberg (Ler) ecotype as a standardized dataset. Recall and precision measurements suggest that Pindel and Clever were the most adaptable to this dataset across all size ranges while Delly performed well for SVs larger than 250 nucleotides. A novel, statistically-sound merging process, which can control the false discovery rate, reduced the false positive rate on the Arabidopsis benchmark dataset used here by >60%. SV-AUTOPILOT provides a meta-tool platform for future SV tool development and the benchmarking of tools on other genomes using a standardized pipeline. It optimizes detection of SVs in non-human genomes using statistically robust merging. The benchmarking in this study has demonstrated the power of 7 different SV tools for analyzing different size classes and types of structural variants. The optional merge

  12. High Speed On-Wafer Characterization Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — At the High Speed On-Wafer Characterization Laboratory, researchers characterize and model devices operating at terahertz (THz) and millimeter-wave frequencies. The...

  13. Interpretation of the Isabella High Wave-Speed Anomaly as the Partially Delaminated High-Density Root of the Southern Sierra Nevada Batholith, California

    Science.gov (United States)

    Saleeby, J.; Le Pourhiet, L.

    2012-12-01

    runs is a chain of events that initiates with the basal thermal perturbation and load of the arclogite root inducing Rayleigh-Taylor (RT) instability within the peridotitic lithosphere, as well as the development of a lower crustal channel along the eastern margin of root, which draws lower crust into the eastern Sierra region from the adjacent Basin and Range. These lead to a lithospheric break-off event that corresponds to the ca. 10 Ma inception of the Sierra Nevada microplate, and which further promotes the east to west delamination of the arclogite root. Initial topography is shown to influence the asymmetry of delamination. Much of our model experimentation consists of testing the influence of crustal rheology on model results. We find that a relatively weak crust for the entire microplate best reproduces rock uplift and tectonic subsidence observations, as well as the timing and source characteristics of observed volcanism. We apply the findings of our 2-D models to 3-D relationships across the southern Sierra region in order to elucidate the time transgressive patterns in uplift, subsidence, volcanism and shallow thermal anomalies in relation to the 3-D delamination of the root, and the production of the higher Vp core of the anomaly. These relations suggest a significant compositional component to the core area of the anomaly (deformed arclogite slab), while the peridotitic envelope produces a broad thermally-induced wave-speed anomaly.

  14. Goddard High Resolution Spectrograph SV/GTO Project

    Science.gov (United States)

    Ebbets, Dennis

    1999-03-01

    Contract number NAS5-30433, known at Ball Aerospace as the GHRS SV/GTO project, supported our participation in the post-launch activities of the Goddard High Resolution Spectrograph aboard the Hubble Space Telescope. The period of performance was December 1988 through December 1998. The contract supported the involvement of Dr Dennis Ebbets in the work of the GHRS Investigation Definition Team, and several of the Ball people in the documentation and publication of results. Three main categories of tasks were covered by this contract; in-orbit calibration of the GHRS, guaranteed time observations, and education and public outreach. The nature and accomplishments of these tasks are described in the report. This summary makes many references to publications in the scientific and technical literature. Appendix A is extracted from a complete bibliography, and lists those papers that are directly related to work performed under this GHRS contract. The tasks related to the in-orbit calibration of the GHRS were by far the largest responsibility during the first six years of the project. During this period Dr. Ebbets was responsible for the definition of calibration requirements, design of experiments, preparation of observing proposals, tracking their implementation and execution, and coordinating the analysis and publication of the results. Prior to the launch of HST in 1990 the observing proposals were developed in cooperation with the scientists on the GHRS DDT, engineers at Ball Aerospace, the operations staff at the STScI, and project coordinators at GSFC.

  15. Results from experimental research on wave components in wind speed taken at the ''Khazar'' off-shore drilling installation

    Energy Technology Data Exchange (ETDEWEB)

    Kurbanov, N.F.; Babaev, A.B.; Ismailov, A.A.; Seidova, N.A.

    1980-01-01

    The statistical characteristics of wave parameters and wind velocity which were measured in natural conditions during severe storms on the ''Khazarn'' off-shore drilling installation are given for sea depths of 45,50 and 54 meters in the Neftianii Kamen, the former Azi Aslanova, and the Livanova-east regions. Using a spectral method, the parameters of the wave are calculated on data from a severe storm.

  16. PHB2_MOUSE Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV ...

    Indian Academy of Sciences (India)

    Sandra Feijoo Bandin

    P16858|G3P_MOUSE. Glyceraldehyde-3-phosphate dehydrogenase OS=Mus musculus GN=Gapdh PE=1 SV=2 sp|P19783|COX41_MOUSE. Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Mus musculus GN=Cox4i1 PE=1 SV=2.

  17. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.

    Directory of Open Access Journals (Sweden)

    Lisheng Peng

    2011-03-01

    Full Text Available Botulinum neurotoxins (BoNTs include seven bacterial toxins (BoNT/A-G that target presynaptic terminals and act as proteases cleaving proteins required for synaptic vesicle exocytosis. Here we identified synaptic vesicle protein SV2 as the protein receptor for BoNT/D. BoNT/D enters cultured hippocampal neurons via synaptic vesicle recycling and can bind SV2 in brain detergent extracts. BoNT/D failed to bind and enter neurons lacking SV2, which can be rescued by expressing one of the three SV2 isoforms (SV2A/B/C. Localization of SV2 on plasma membranes mediated BoNT/D binding in both neurons and HEK293 cells. Furthermore, chimeric receptors containing the binding sites for BoNT/A and E, two other BoNTs that use SV2 as receptors, failed to mediate the entry of BoNT/D suggesting that BoNT/D binds SV2 via a mechanism distinct from BoNT/A and E. Finally, we demonstrated that gangliosides are essential for the binding and entry of BoNT/D into neurons and for its toxicity in vivo, supporting a double-receptor model for this toxin.

  18. An investigation of the occurrence of sv40 antibodies in South Africa ...

    African Journals Online (AJOL)

    Four of the samples were from the healthy population group and the remaining 1 (1/64) was from the patient group. An SV40 antibody-blocking assay and a Western blot were used as additional confirmation for the SV40 antibodies, whereas the Western blot assay developed a single common band on all 5 samples.

  19. Spectroscopic observations of the RS CVn-type binary systems SV Cam and XY UMa

    Science.gov (United States)

    Rainger, P. P.; Hilditch, R. W.; Edwin, R. P.

    1991-01-01

    Radial velocities of the primary components of the two RS CVn-type binary systems SV Cam and XY UMa are presented, for the first time for XY UMa. Neither secondary component could be detected. A change of 5.0 + or - 13 km/sec in the systemic velocity of SV Cam is found over 40 years, which lends some support to the current model of SV Cam being a triple system. If the masses of the G3 V primary components of both systems are assumed to be 1 solar mass, then the secondaries are 0.7 (SV Cam) and 0.6 (XY UMa) solar masses; all four stars are main sequence objects with SV Cam being rather more evolved than XY UMa.

  20. Spectroscopic observations of the RS CVn-type binary systems SV Cam and XY UMa

    Energy Technology Data Exchange (ETDEWEB)

    Rainger, P.P.; Hilditch, R.W.; Edwin, R.P. (Saint Andrews Univ. (UK). Observatory)

    1991-01-01

    Radial velocities of the primary components of the two RS CVn-type binary systems SV Cam and XY UMa are presented, for the first time for XY UMa. Neither secondary component could be detected. A change of 5.0+-1.3km s{sup -1} in the systemic velocity of SV Cam is found over 40 years which lends some support to the current model of SV Cam being a triple system. If the masses of the G3 V primary components of both systems are assumed to be one solar mass, then the secondaries are 0.7 (SV CAM) and 0.6 (XY UMa) solar masses; all four stars are main sequence objects with SV Cam being rather more evolved than XY UMa. (author).

  1. SV40 DNA amplification and reintegration in surviving hamster cells after 60Co gamma-irradiation.

    Science.gov (United States)

    Lücke-Huhle, C; Pech, M; Herrlich, P

    1990-10-01

    SV40-transformed Chinese hamster embryo cells were exposed to 60Co gamma-irradiation and the fate of the integrated SV40 sequences was pursued over a period of 20 days following radiation exposure. As shown by colony hybridization, integrated SV40 sequences were amplified in surviving and non-surviving cells. At later times, however, clonal sublines of surviving cells grown for 20-30 cell generations after irradiation had lost most of their amplified SV40 copies but showed altered restriction fragment patterns indicating reintegration of SV40 sequences at new sites of the hamster genome. This suggests that 60Co gamma-irradiation can generate mutations by inducing over-replication of chromosome segments that are then substrates of enzymatic rearrangements.

  2. Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain.

    Science.gov (United States)

    Dunn, Amy R; Hoffman, Carlie A; Stout, Kristen A; Ozawa, Minagi; Dhamsania, Rohan K; Miller, Gary W

    2017-12-21

    The synaptic vesicle glycoprotein 2C (SV2C) is an undercharacterized protein with enriched expression in phylogenetically old brain regions. Its precise role within the brain is unclear, though various lines of evidence suggest that SV2C is involved in the function of synaptic vesicles through the regulation of vesicular trafficking, calcium-induced exocytosis, or synaptotagmin function. SV2C has been linked to multiple neurological disorders, including Parkinson's disease and psychiatric conditions. SV2C is expressed in various cell types-primarily dopaminergic, GABAergic, and cholinergic cells. In mice, it is most highly expressed in nuclei within the basal ganglia, though it is unknown if this pattern of expression is consistent across species. Here, we use a custom SV2C-specific antiserum to describe localization within the brain of mouse, nonhuman primate, and human, including cell-type localization. We found that the immunoreactivity with this antiserum is consistent with previously-published antibodies, and confirmed localization of SV2C in the basal ganglia of rodent, rhesus macaque, and human. We observed strongest expression of SV2C in the substantia nigra, ventral tegmental area, dorsal striatum, pallidum, and nucleus accumbens of each species. Further, we demonstrate colocalization between SV2C and markers of dopaminergic, GABAergic, and cholinergic neurons within these brain regions. SV2C has been increasingly linked to dopamine and basal ganglia function. These antisera will be an important resource moving forward in our understanding of the role of SV2C in vesicle dynamics and neurological disease. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. Wave Solutions

    CERN Document Server

    Christov, Ivan C

    2012-01-01

    In classical continuum physics, a wave is a mechanical disturbance. Whether the disturbance is stationary or traveling and whether it is caused by the motion of atoms and molecules or the vibration of a lattice structure, a wave can be understood as a specific type of solution of an appropriate mathematical equation modeling the underlying physics. Typical models consist of partial differential equations that exhibit certain general properties, e.g., hyperbolicity. This, in turn, leads to the possibility of wave solutions. Various analytical techniques (integral transforms, complex variables, reduction to ordinary differential equations, etc.) are available to find wave solutions of linear partial differential equations. Furthermore, linear hyperbolic equations with higher-order derivatives provide the mathematical underpinning of the phenomenon of dispersion, i.e., the dependence of a wave's phase speed on its wavenumber. For systems of nonlinear first-order hyperbolic equations, there also exists a general ...

  4. Individual and Institutional Predictors of IPV/SV Screening in College Health Centers.

    Science.gov (United States)

    Sutherland, Melissa A; Fantasia, Heidi Collins; Hutchinson, M Katherine; Katz, Jennifer

    2017-11-01

    Intimate partner violence (IPV) and sexual violence (SV) are significant public health issues for women, particularly for college women. IPV and SV have been associated with numerous adverse health consequences and involvement in unhealthy behaviors. Given the health risks and high rates of IPV/SV among college women, it is important to understand and promote screening in this population. The purpose of this study was to examine college women's experiences with IPV/SV screening at college health centers and identify individual and institutional characteristics associated with screening. Random samples of female undergraduate college students from five colleges in the northeast United States were recruited to participate in an anonymous online survey in January 2015. Inclusion criteria included at least one visit to the college health center during the preceding fall semester. Participants were questioned regarding demographics and whether they were screened or asked about IPV/SV at the college health center. A total of 873 women met the inclusion criteria and completed surveys. Only 10.2% of the college women in the study reported that they were screened for IPV/SV at their most recent visit to the college health center. Participants from public colleges/universities were 3 times more likely than others to report screening, whereas participants from urban college/university campuses were more than twice as likely as others to report screening. College women who went to the college health center for a gynecological or sexual health reason were nearly 4 times as likely as other women to report being screened for IPV/SV. Low rates of IPV/SV screening at college health centers represent missed opportunities. Further research across more numerous and diverse college sites is needed to understand the factors that promote or inhibit IPV/SV screening in college health centers to develop interventions to facilitate routine screening practices.

  5. Deformed special relativity with an invariant minimum speed and its ...

    Indian Academy of Sciences (India)

    and thus the Galilean frame S takes place, recovering Lorentz transformations. 2. Pramana – J. Phys., Vol. 71, No. ... Let us assume the reference frame S with a speed v in relation to the ultra- referential SV according to figure 1. ...... [10] M Carmeli and T Kuzmenko, arXiv:astro-ph/0102033. [11] B P Schmidt et al, Astrophys.

  6. A Numerical Study of the Regimes of Weak Fluctuation Theory for Ocean Acoustic Propagation through Random Internal Wave Sound Speed Fields

    Science.gov (United States)

    2007-03-01

    applied to a radio wave propagation problem in the atmosphere ( Jensen , Kuperman, Porter & Schmidt, 2000). The parabolic equation (PE) method has found...wide application in the field of underwater acoustics after Hardin and Tappert (1973) devised an efficient model based on Fourier transforms. The PE...equation follows the treatment by Jensen , Kuperman, Porter & Schmidt (2000). There are different kinds of parabolic equations, but this thesis

  7. A Consistent Wave Impact Load Model for Studying Structure, Equipment Ruggedness, Shock Isolation Seats, and Human Comfort in Small High Speed Craft

    Science.gov (United States)

    2016-11-01

    information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE 30...of acceleration application (i.e., jerk ), peak amplitude, and pulse duration, Eiband (1959). Consistent Wave Slam Type The time history responses of...systematic research for effects other than vertical, and there is a need for controlled studies to better describe and quantify the bounds of human

  8. Illusory double epenthesis in the [s_V] context among Japanese listeners: an exploratory study.

    Science.gov (United States)

    Yamada, Jun

    2012-10-01

    Previous studies showed that English listeners tend to hear an [s_V] segment with [_] a silent gap as [sCV], where [C] is an epenthetic stop consonant such as [t]. The present study found that Japanese listeners, whose native language disallows [CCV] but allows [CVCV], often perceive [s_V] as [sVCV]. It is suggested that such illusory double-epenthetic percepts are generated via a two-step process, i.e., the vowel of [s_V] triggers an epenthetic consonant before it, and the initial consonant [s] and the newly generated epenthetic consonant [C] sequentially aligned induce a vowel epenthesis [V] between them.

  9. Fanconi anemia patients are more susceptible to infection with tumor virus SV40.

    Directory of Open Access Journals (Sweden)

    Manola Comar

    Full Text Available Fanconi anemia (FA is a recessive DNA repair disease characterized by a high predisposition to developing neoplasms. DNA tumor polyomavirus simian virus 40 (SV40 transforms FA fibroblasts at high efficiency suggesting that FA patients could be highly susceptible to SV40 infection. To test this hypothesis, the large tumor (LT antigen of SV40, BKV, JCV and Merkel Cell (MC polyomaviruses were tested in blood samples from 89 FA patients and from 82 of their parents. Two control groups consisting of 47 no-FA patients affected by other genetic bone marrow failure diseases and 91 healthy subjects were also evaluated. Although JCV, BKV and MC were not found in any of the FA samples, the prevalence and viral load of SV40 were higher in FA patients (25%; mean viral load: 1.1×10(2 copies/10(5cells as compared with healthy individuals (4.3%; mean viral load: 0.8×10(1 copies/10(5cells and genetic controls (0% (p<0.005. A marked age-dependent frequency of SV40 was found in FA with respect to healthy subjects suggesting that, although acquired early in life, the virus can widespread more easily in specific groups of population. From the analysis of family pedigrees, 60% of the parents of SV40-positive probands were positive for the virus compared to 2% of the parents of the SV40-negative probands (p<0.005. It is worthy of note that the relative frequency of SV40-positive relatives detected in this study was the highest ever reported, showing that asymptomatic FA carriers are also more susceptible to SV40. In conclusion, we favor the hypothesis that SV40 spread could be facilitated by individuals who are genetically more susceptible to infection, such as FA patients. The increased susceptibility to SV40 infection seems to be associated with a specific defect of the immune system which supports a potential interplay of SV40 with an underlying genetic alteration that increases the risk of malignancies.

  10. On the impact of wave-current on Stokes waves | Oyetunde | Journal ...

    African Journals Online (AJOL)

    This study considers the impact of wave - current on Stokes waves in deep water. Using separately, the third, fourth and fifth order approximations of wave profile functions respectively and the determined expressions for wave – current speed , it is shown that the wave - current speed is more intense on the surface of the ...

  11. On the effects of wave steepness on higher order Stokes waves ...

    African Journals Online (AJOL)

    The effect of wave steepness on higher order finite amplitude Stokes waves is investigated analytically and numerically. It is shown that the phase speed increases as the wave steepness increases thereby initiating the wave instabilities. As the order increases, the phase speed also increases .However, the impact of wave ...

  12. GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv background.

    NARCIS (Netherlands)

    Pattij, T.; Groenink, L.; Oosting, R.S.; Gugten, J. van der; Maes, R.A.A.; Olivier, B.

    2002-01-01

    Previous studies in 5-HT(1A) receptor knockout (1AKO) mice on a mixed Swiss Websterx129/Sv (SWx129/Sv) and a pure 129/Sv genetic background suggest a differential gamma-aminobutyric acid (GABA(A))-benzodiazepine receptor complex sensitivity in both strains, independent from the anxious phenotype. To

  13. Highly accurate P-SV complete synthetic seismograms using modified DSM operators

    Science.gov (United States)

    Takeuchi, Nozomu; Geller, Robert J.; Cummins, Phil R.

    In previous papers [Cummins et al., 1994ab] (hereafter referred to as DSMI and DSMII respectively), we presented accurate methods for computing complete synthetic seismograms for SH and P-SV respectively in a spherical earth model. The SH calculations used computationally efficient modified matrix operators, but the P-SV synthetics were computationally intensive. Geller and Takeuchi [1995] (hereafter referred to as GT95) presented a general theory for deriving modified operators and gave the explicit form of the modified operators for the P-SV case in cylindrical or cartesian coordinates. In this paper we extend GT95's results to derive modified operators for the P-SV case in spherical coordinates. The use of the modified operators reduces the CPU time by a factor of about 5 without a loss of accuracy. 10 CPU min on a SPARC-20 workstation with one CPU are required to compute a profile of synthetic seismograms from DC to 20 sec period.

  14. Når børn lærer at svømme

    DEFF Research Database (Denmark)

    2006-01-01

    DVD'en giver svømmeinstruktøren indblik i og viden om, hvordan børn lærer at svømme. DVD'en indeholder kapitler om Kroppen i vand, Vandbasis, Butterfly, Rygcrawl, Brystsvømning, Crawl, Livredning og Aktivitetsjustering. I hvert kapitel tages der udgangspunkt i begyndersvømmerens typiske bevægelser...

  15. In vitro and in vivo Functional Characterization of Gutless Recombinant SV40-derived CFTR Vectors

    Science.gov (United States)

    Mueller, Christian; Strayer, Marlene S; Sirninger, Jeffery; Braag, Sofia; Branco, Francisco; Louboutin, Jean-Pierre; Flotte, Terence R.; Strayer, David S.

    2009-01-01

    In cystic fibrosis (CF) respiratory failure caused by progressive airway obstruction and tissue damage is primarily a result of the aberrant inflammatory responses to lung infections with Pseudomonas aeruginosa. Despite considerable improvement in patient survival, conventional therapies are mainly supportive. Recent progress towards gene therapy for CF has been encouraging; however, several factors such as immune response and transduced cell turnover remain as potential limitations to CF gene therapy. As alternative gene therapy vectors for CF we examined the feasibility of using SV40-derived vectors (rSV40s) which may circumvent some of these obstacles. To accommodate the large CFTR cDNA, we removed not only SV40 Tag genes, but also all capsid genes. We therefore tested whether “gutless” rSV40s could be packaged and were able to express a functional human CFTR cDNA. Results from our in vitro analysis determined that rSV40-CFTR was able to successfully result in the expression of CFTR protein which localized to the plasma membrane and restored channel function to CFTR deficient cells. Similarly in vivo experiments delivering rSV40-CFTR to the lungs of Cftr−/− mice resulted in a reduction of the pathology associated with intra-tracheal pseudomona aeruginosa challenge. rSV40-CFTR treated mice had had less weight loss when compared to control treated mice as well as demonstrably reduced lung inflammation as evidence by histology and reduced inflammatory cytokines in the BAL. The reduction in inflammatory cytokine levels led to an evident decrease in neutrophil influx to the airways. These results indicate that further study of the application of rSV40-CFTR to CF gene therapy is warranted. PMID:19890354

  16. Fatal SV40-associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque.

    Science.gov (United States)

    Song, M; Mulvihill, M S; Williams, K D; Collins, B H; Kirk, A D

    2018-02-01

    Recrudescence of latent and dormant viruses may lead to overwhelming viremia in immunosuppressed hosts. In immunocompromised hosts, Simian virus 40 (SV40) reactivation is known to cause nephritis and demyelinating central nervous system disease. Here, we report SV40 viremia leading to fatal interstitial pneumonia in an immunosuppressed host following renal allotransplantation. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  17. Modulation of the shape and speed of a chemical wave in an unstirred Belousov-Zhabotinsky reaction by a rotating magnet.

    Science.gov (United States)

    Okano, Hideyuki; Kitahata, Hiroyuki

    2013-04-01

    The objective of this study was to observe whether a rotating magnetic field (RMF) could change the anomalous chemical wave propagation induced by a moderate-intensity gradient static magnetic field (SMF) in an unstirred Belousov-Zhabotinsky (BZ) reaction. The application of the SMF (maximum magnetic flux density = 0.22 T, maximum magnetic flux density gradient = 25.5 T/m, and peak magnetic force product (flux density × gradient) = 4 T(2) /m) accelerated the propagation velocity in a two-dimensional pattern. Characteristic anomalous patterns of the wavefront shape were generated and the patterns were dependent on the SMF distribution. The deformation and increase in the propagation velocity were diminished by the application of an RMF at a rotation rate of 1 rpm for a few minutes. Numerical simulation by means of the time-averaged value of the magnetic flux density gradient or the MF gradient force over one rotation partially supported the experimental observations. These considerations suggest that RMF exposure modulates the chemical wave propagation and that the degree of modulation could be, at least in part, dependent on the time-averaged MF distribution over one rotation. Bioelectromagnetics 34:220-230, 2013. © 2012 Wiley Periodicals, Inc. Copyright © 2012 Wiley Periodicals, Inc.

  18. Detonation Wave Profile

    Energy Technology Data Exchange (ETDEWEB)

    Menikoff, Ralph [Los Alamos National Laboratory

    2015-12-14

    The Zel’dovich-von Neumann-Doering (ZND) profile of a detonation wave is derived. Two basic assumptions are required: i. An equation of state (EOS) for a partly burned explosive; P(V, e, λ). ii. A burn rate for the reaction progress variable; d/dt λ = R(V, e, λ). For a steady planar detonation wave the reactive flow PDEs can be reduced to ODEs. The detonation wave profile can be determined from an ODE plus algebraic equations for points on the partly burned detonation loci with a specified wave speed. Furthermore, for the CJ detonation speed the end of the reaction zone is sonic. A solution to the reactive flow equations can be constructed with a rarefaction wave following the detonation wave profile. This corresponds to an underdriven detonation wave, and the rarefaction is know as a Taylor wave.

  19. Superluminal waves in amplifying media

    Energy Technology Data Exchange (ETDEWEB)

    Oraevsky, Anatolii N [P.N. Lebedev Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation)

    1998-12-31

    In amplifying media steady-state waves can travel faster than the speed of light in vacuum without violating the principles of special relativity. The possibility of generating superluminal waves in induced elementary particle production processes is discussed. (methodological notes)

  20. Wave turbulence in annular wave tank

    Science.gov (United States)

    Onorato, Miguel; Stramignoni, Ettore

    2014-05-01

    We perform experiments in an annular wind wave tank at the Dipartimento di Fisica, Universita' di Torino. The external diameter of the tank is 5 meters while the internal one is 1 meter. The tank is equipped by two air fans which can lead to a wind of maximum 5 m/s. The present set up is capable of studying the generation of waves and the development of wind wave spectra for large duration. We have performed different tests including different wind speeds. For large wind speed we observe the formation of spectra consistent with Kolmogorv-Zakharov predictions.

  1. Speed mathematics

    CERN Document Server

    Handley, Bill

    2012-01-01

    This new, revised edition of the bestselling Speed Mathematics features new chapters on memorising numbers and general information, calculating statistics and compound interest, square roots, logarithms and easy trig calculations. Written so anyone can understand, this book teaches simple strategies that will enable readers to make lightning-quick calculations. People who excel at mathematics use better strategies than the rest of us; they are not necessarily more intelligent. With Speed Mathematics you'll discover methods to make maths easy and fun. This book is perfect for stud

  2. Temperature-sensitive SV40-immortalized rat middle ear epithelial cells.

    Science.gov (United States)

    Toyama, Katsuhiro; Kim, Youngki; Paparella, Michael M; Lin, Jizhen

    2004-12-01

    The proliferation and differentiation of middle ear epithelial cells are essential in both normal and diseased middle ears. The normal situation involves physiologic growth and renewal of the epithelium, and the diseased situation involves pathological changes of the epithelium such as mucous cell metaplasia and ciliated cell proliferation in otitis media. In this study, we used a temperature-sensitive large T antigen (the SV40 mutant) to transduce and immortalize the primary culture of middle ear epithelial cells. SV40-immortalized middle ear epithelial cells have been cultured for more than 50 passages and are stable morphologically. Their nonimmortalized parent cells died at the second passage. Immortalized middle ear epithelial cells carrying the SV40 mutant show a monolayer, cobblestonelike morphology. The cell line expresses characteristic middle ear mucosal molecules such as mucins, keratins, and collagens. It also responds to temperature changes; namely, cells proliferate at 33 degrees C, when the SV40 antigen is active, and differentiate at 39 degrees C, when the SV40 antigen is inactive. Therefore, we conclude that a temperature-sensitive middle ear epithelial cell line has successfully been established.

  3. Surface waves in fibre-reinforced anisotropic elastic media

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    MS received 1 March 2002. Abstract. In the paper under discussion, the problem of surface waves in fibre- reinforced anisotropic elastic media has been studied. The authors express the plane strain displacement components in terms of two scalar potentials to decouple the plane motion into P and SV waves. In the present ...

  4. Dynamic VaR Measurement of Gold Market with SV-T-MN Model

    Directory of Open Access Journals (Sweden)

    Fenglan Li

    2017-01-01

    Full Text Available VaR (Value at Risk in the gold market was measured and predicted by combining stochastic volatility (SV model with extreme value theory. Firstly, for the fat tail and volatility persistence characteristics in gold market return series, the gold price return volatility was modeled by SV-T-MN (SV-T with Mixture-of-Normal distribution model based on state space. Secondly, future sample volatility prediction was realized by using approximate filtering algorithm. Finally, extreme value theory based on generalized Pareto distribution was applied to measure dynamic risk value (VaR of gold market return. Through the proposed model on the price of gold, empirical analysis was investigated; the results show that presented combined model can measure and predict Value at Risk of the gold market reasonably and effectively and enable investors to further understand the extreme risk of gold market and take coping strategies actively.

  5. Kvinder indlagt med svær præeklampsi efterlyser sammenhæng

    DEFF Research Database (Denmark)

    Stenshøj, Jette; Aagaard, Hanne

    2014-01-01

    Præeklampsi rammer 2-5 % af alle gravide i Danmark. Sygdommen kan udvikle sig alvorligt og eneste behandling er forløsning af det ofte præmature barn. Kvinder med svær præeklampsi gennemlever psykologisk stress, og de er samtidig i risiko for en efterfødselsreaktion. Formålet med studiet er......, at undersøge kvinders oplevelse og vurdering af den stress, der kan være forbundet med indlæggelse med svær præeklampsi. Studiet er baseret på interview med tre kvinder efter indlæggelse med svær præeklampsi. Benner og Wrubels forståelse af stress er anvendt som teoretisk ramme for udarbejdelse af...

  6. Solid state fermentation and production of rifamycin SV using Amycolatopsis mediterranei.

    Science.gov (United States)

    Nagavalli, M; Ponamgi, S P D; Girijashankar, V; Venkateswar Rao, L

    2015-01-01

    Production of Rifamycin SV from cheaper agro-industrial by-products using mutant strain of Amycolatopsis mediterranei OVA5-E7 in solid state fermentation (SSF) was optimized. Among the agro-based substrates used, ragi bran was found suitable for maximizing the yield of Rifamycin SV (1310 mg 100 g(-1) ds). The yield can be further enhanced to 19·7 g Kg(-1) of dry substrate by supplementing the substrate with deoiled cotton cake (10% w/w) using optimized fermentation parameters such as maintaining 80% moisture, pH 7·0, 30°C incubation temperature, inoculum 25% v/w and carrying the solid state fermenting for 9 days. Manipulating these seven specifications, the end product yield achieved in our experimentation was 20 g of Rifamycin SV Kg(-1) ds. Eventually, an overall 5-fold improvement in Rifamycin SV production was achieved. Antibiotics such as rifamycin are broad-spectrum antimicrobial drugs used in large-scale worldwide as human medicine towards controlling diseases. Amycolatopsis mediterranei strain which produces this antibiotic was earlier used in submerged fermentation yielded lower amounts of rifamycin. By employing cheaper agro-industrial by-products, we produced upto 20 g rifamycin SV per Kg dry substrate used under optimized solid state fermentation conditions. Keeping in view, the role of rifamycin in meeting the medical demands of world's increasing population; we successfully used an improved strain on cheaper substrates with optimized fermentation parameters and achieved a 5-fold improvement in rifamycin SV production. © 2014 The Society for Applied Microbiology.

  7. A very late viral protein triggers the lytic release of SV40.

    Directory of Open Access Journals (Sweden)

    Robert Daniels

    2007-07-01

    Full Text Available How nonenveloped viruses such as simian virus 40 (SV40 trigger the lytic release of their progeny is poorly understood. Here, we demonstrate that SV40 expresses a novel later protein termed VP4 that triggers the timely lytic release of its progeny. Like VP3, VP4 synthesis initiates from a downstream AUG start codon within the VP2 transcript and localizes to the nucleus. However, VP4 expression occurs approximately 24 h later at a time that coincides with cell lysis, and it is not incorporated into mature virions. Mutation of the VP4 initiation codon from the SV40 genome delayed lysis by 2 d and reduced infectious particle release. Furthermore, the co-expression of VP4 and VP3, but not their individual expression, recapitulated cell lysis in bacteria. Thus, SV40 regulates its life cycle by the later temporal expression of VP4, which results in cell lysis and enables the 50-nm virus to exit the cell. This study also demonstrates how viruses can generate multiple proteins with diverse functions and localizations from a single reading frame.

  8. Ikona Bogorodice s Djetetom iz crkve Sv. Nikole na Prijekom u Dubrovniku

    OpenAIRE

    Demori Staničić, Zoraida

    2013-01-01

    Ikona Bogorodice s Djetetom iz crkve sv. Nikole na Prijekom u Dubrovniku, nakon provedenog konzervatorsko-restauratorskog zahvata, na temelju stilske analize povezuje se s poznatom „Bogorodicom benediktinki“ iz Zadra i datira u isto vrijeme oko 1300. godine. Analizira se ikonografija ikone te otvara problem utjecaja slikarstva istočnog Mediterana na slikarstvo Dalmacije u XIII. stoljeću.

  9. Reply to Comments on Measuring marine iron(III) complexes by CLE-AdSV

    NARCIS (Netherlands)

    Town, R.M.; Leeuwen, van H.P.

    2005-01-01

    The interpretation of CLE-AdSV based iron(iii) speciation data for marine waters has been called into question in light of the kinetic features of the measurement. The implications of the re-think may have consequences for understanding iron biogeochemistry and its impact on ecosystem functioning.

  10. The observational signature of modelled torsional waves and comparison to geomagnetic jerks

    Science.gov (United States)

    Cox, G. A.; Livermore, P. W.; Mound, J. E.

    2016-06-01

    Torsional Alfvén waves involve the interaction of zonal fluid flow and the ambient magnetic field in the core. Consequently, they perturb the background magnetic field and induce a secondary magnetic field. Using a steady background magnetic field from observationally constrained field models and azimuthal velocities from torsional wave forward models, we solve an induction equation for the wave-induced secular variation (SV). We construct time series and maps of wave-induced SV and investigate how previously identified propagation characteristics manifest in the magnetic signals, and whether our modelled travelling torsional waves are capable of producing signals that resemble jerks in terms of amplitude and timescale. Fast torsional waves with amplitudes and timescales consistent with a recent study of the 6 yr Δ LOD signal induce very rapid, small (maximum ∼ 2 nT/yr at Earth's surface) SV signals that would likely be difficult to be resolve in observations of Earth's SV. Slow torsional waves with amplitudes and timescales consistent with other studies produce larger SV signals that reach amplitudes of ∼ 20 nT/yr at Earth's surface. We applied a two-part linear regression jerk detection method to the SV induced by slow torsional waves, using the same parameters as used on real SV, which identified several synthetic jerk events. As the local magnetic field morphology dictates which regions are sensitive to zonal core flow, and not all regions are sensitive at the same time, the modelled waves generally produce synthetic jerks that are observed on regional scales and occur in a single SV component. However, high wave amplitudes during reflection from the stress-free CMB induce large-scale SV signals in all components, which results in a global contemporaneous jerk event such as that observed in 1969. In general, the identified events are periodic due to waves passing beneath locations at fixed intervals and the SV signals are smoothly varying. These smooth

  11. INFLUENCE OF OPERABILITY CRITERIA LIMITING VALUES ON SHIP SPEED

    Directory of Open Access Journals (Sweden)

    Jasna Prpić-Oršić

    2016-09-01

    Full Text Available When the ship is caught in heavy seas, there are two manoeuvres that the shipmaster can undertake to avoid excessive ship motion and hull damage: changing course or voluntary speed reduction. This paper presents a study of the effect of the various voluntary speed reduction criteria to attainable speed of ship on seaway. The speed loss is calculated by taking into account wind and wave effect on ship speed, the engine and propeller performance in actual seas as well as the mass inertia of the ship. The attainable ship speed for ship in head, following and beam waves by accounting for voluntary speed reduction is estimated for various significant wave height. The criteria of slamming, deck wetness, propeller emergence, excessive accelerations and roll are taken into account. The impact of variations of the limiting values of certain criteria due to which the captain intentionally reduces the ship speed is analysed and discussed.

  12. The diagnostic performances of conventional strain elastography (SE), acoustic radiation force impulse (ARFI) imaging and point shear-wave speed (pSWS) measurement for non-calcified thyroid nodules.

    Science.gov (United States)

    Chen, Bao-Ding; Xu, Hui-Xiong; Zhang, Yi-Feng; Liu, Bo-Ji; Guo, Le-Hang; Li, Dan-Dan; Zhao, Chong-Ke; Li, Xiao-Long; Wang, Dan; Zhao, Shuang-Shuang

    2017-01-01

    Non-calcified thyroid nodules are relatively difficult to diagnose only relying on features of at conventional US images. To investigate the diagnostic performances of conventional strain elastography (SE), acoustic radiation force impulse (ARFI) SE and point shear-wave speed (pSWS) measurement for non-calcified thyroid nodules. A total of 201 non-calcified thyroid nodules in 195 patients were studied. They were examined with conventional ultrasound (US), conventional SE, ARFI SE and pSWS measurement. Their diagnostic performances and multivariable models were assessed with receiver operating characteristic (ROC) curve and logistic regression analyses respectively. There were 156 benign and 45 malignant non-calcified nodules proven by histopathology or cystology. The mean diameters of the nodules were 21.2±10.8 mm. Areas under receiver operating characteristic curve (AUCs) of elastography features (ranged, 0.488-0.745) were all greater than that of US (ranged, 0.111-0.332). At multivariate analysis, there were three predictors of malignancy for non-calcified nodules, including pSWS of nodule (odds ratio [OR], 34.960; 95% CI, 11.582-105.529), marked hypoechogenicity (OR, 16.223; 95% CI, 1.761-149.454) and ARFI SE grade (OR, 10.900; 95% CI, 3.567-33.310). US+SE+pSWS owned the largest AUC (0.936; 95% CI, 0.887-0.985; P < 0.05), followed by US+pSWS (0.889; 95% CI, 0.823-0.955), and the poorest was US (0.727; 95% CI, 0.635-0.819). ARFI SE and pSWS measurement had better diagnostic performances than conventional SE and US. When US combined with SE and pSWS measurement, it could achieve an excellent diagnostic performance and might contribute a better decision-making of FNA for non-calcified thyroid nodules.

  13. SV3R : un framework pour la gestion de la variabilité des services

    Directory of Open Access Journals (Sweden)

    Boutaina Chakir

    2014-11-01

    Full Text Available The emergence and expansion of the development paradigm based on service-oriented approaches have been behind the elaboration of new models and methods that aim at facilitating the reuse of services within multiples context of use. This requires providing systematically services with several possible realizations. Among the promising approaches that achieve this objective is the management of variability which has been widely adopted by the software engineering disciplines and whose objective is to facilitate the adaptation or the configuration of software artifacts in a systematic way. Hence, in this work we provide a framework for the development (for and by reuse of services supporting variability, called “SV3R” (Service Variability Representation and Resolution for Reuse. This paper introduces at first the concept of variability. Afterwards, it presents some related work, before giving an overview of the framework SV3R and describing

  14. Validation of the portuguese version of the tampa scale for kinesiophobia heart (TSK-SV heart

    Directory of Open Access Journals (Sweden)

    Gabriela Lima de Melo Ghisi

    Full Text Available ABSTRACT Introduction: It has been shown that kinesiophobia has a negative influence on the outcomes of cardiac rehabilitation and consequently is important for the clinical setting. Objective: The objective of this study was to translate, culturally adapt, and psychometrically validate the Tampa Scale for Kinesiophobia Heart (TSK-SV Heart to Brazilian Portuguese. Methods: The Portuguese version was tested in 300 patients in cardiac rehabilitation. Test-retest reliability was assessed by intraclass correlation coefficient, internal consistency by Cronbach’s alpha, and criterion validity was assessed with respect to patients’ education, income, duration of cardiac rehabilitation, and sex. Results: After intraclass correlation coefficient analysis, one item was excluded. All four areas were considered internally consistent (α >0.7. Significant differences between mean total scores and income (p 37. Conclusions: The Brazilian Portuguese version of TSK-SV Heart demonstrated sufficient reliability, consistency and validity, supporting its use in future studies.

  15. In situ study of SV40 virus DNA in lytic infection by mild loosening of nucleoproteins.

    Science.gov (United States)

    Puvion-Dutilleul, F; Pedron, J; Lange, M

    1980-11-01

    We have studied SV40 (simian virus40) nucleoprotein in permissively infected monkey kidney cell cultures (CV1) by a procedure which does not require the isolation of the SV40 chromosomes. Treatment of the cells by a low ionic strenght medium containing Photo flo produces a mild loosening of nucleoproteins, and permits the in situ study in ultrathin sections of virus components and their relationships with host cell chromatin. RNP and DNP could be distinguished by uranyl-EDTA-lead staining (for RNP) and by DNase digestion. SV40 DNA was observed as circular molecules, either free or connected with either RNP fibrils or virus capsids. These three aspects were interpreted, respectively, as viral minichromosomes, transcription of virus genome and partially encapsidated virus DNA. During encapsidation a few virus particles appear to be bound to host chromatin. Many, if not all, seemingly mature viruses, singly or in small linear clusters, are also aligned on host chromatin. Some of these observations were corroborated by the Miller spreading technique. They are consistent with a role for the host cell chromatin in the production of nuclear viruses.

  16. Vectors bicistronically linking a gene of interest to the SV40 large T antigen in combination with the SV40 origin of replication enhance transient protein expression and luciferase reporter activity

    OpenAIRE

    Mahon, Matthew J.

    2011-01-01

    The Simian Virus large T antigen (SVLT) induces replication of plasmids bearing the SV40 origin of replication (SV40 ori) within mammalian cells. The internal ribosomal entry site (IRES) is an element that allows for the co-translation of proteins from one polycistronic mRNA. Through the combination of these elements, IRES-dependent co-expression of a protein of interest and the SVLT, either constitutive or regulated, on plasmids bearing the SV40 ori generates a positive feedback loop, result...

  17. Validity and reliability of the Brazilian version of Yale-Brown obsessive compulsive scale-shopping version (YBOCS-SV).

    Science.gov (United States)

    Leite, Priscilla Lourenço; Filomensky, Tatiana Zambrano; Black, Donald W; Silva, Adriana Cardoso

    2014-08-01

    The Yale-Brown Obsessive Compulsive Scale-Shopping Version (YBOCS-SV) is considered the gold standard in the assessment of shopping severity. It is designed to assess cognitions and behaviors relating to compulsive buying behavior. The present study aims to assess the validity of the Brazilian version of this scale. For the study, composed the sample 610 participants: 588 subjects of a general population and 22 compulsive buyers. Factorial analysis was performed to assess the relations and the correlation between the YBOCS-SV, the Compulsive Buying Scale (CBS), and Richmond Compulsive Buying Scale (RCBS), was assessed using Pearson coefficient, for study of convergent and divergent validity. Cronbach's alpha coefficients were used to assess internal consistency. The results show good to excellent psychometric parameters for the YBOCS-SV in its Brazilian version. With regard to correlations, the YBOCS-SV is inversely and proportionally correlated with CBS and the RCBS, indicating that the YBOCS-SV is an excellent instrument for screening compulsive buying. The YBOCS-SV presented high alpha coefficient of Cronbach's alpha (0.92), demonstrating good reliability. The Brazilian version of the YBOCS-SV is indicated to diagnose compulsive buying disorder, and likely use for the purposes intended in the Brazilian population. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Discovery of heterocyclic nonacetamide synaptic vesicle protein 2A (SV2A) ligands with single-digit nanomolar potency: opening avenues towards the first SV2A positron emission tomography (PET) ligands.

    Science.gov (United States)

    Mercier, Joël; Archen, Laurence; Bollu, Véronique; Carré, Stéphane; Evrard, Yves; Jnoff, Eric; Kenda, Benoît; Lallemand, Bénédicte; Michel, Philippe; Montel, Florian; Moureau, Florence; Price, Nathalie; Quesnel, Yannick; Sauvage, Xavier; Valade, Anne; Provins, Laurent

    2014-04-01

    The role of the synaptic vesicle protein 2A (SV2A) protein, target of the antiepileptic drug levetiracetam, is still mostly unknown. Considering its potential to provide in vivo functional insights into the role of SV2A in epileptic patients, the development of an SV2A positron emission tomography (PET) tracer has been undertaken. Using a 3D pharmacophore model based on close analogues of levetiracetam, we report the rationale design of three heterocyclic non-acetamide lead compounds, UCB-A, UCB-H and UCB-J, the first single-digit nanomolar SV2A ligands with suitable properties for development as PET tracers. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Theory of Gravitational Waves

    CERN Document Server

    Tiec, Alexandre Le

    2016-01-01

    The existence of gravitational radiation is a natural prediction of any relativistic description of the gravitational interaction. In this chapter, we focus on gravitational waves, as predicted by Einstein's general theory of relativity. First, we introduce those mathematical concepts that are necessary to properly formulate the physical theory, such as the notions of manifold, vector, tensor, metric, connection and curvature. Second, we motivate, formulate and then discuss Einstein's equation, which relates the geometry of spacetime to its matter content. Gravitational waves are later introduced as solutions of the linearized Einstein equation around flat spacetime. These waves are shown to propagate at the speed of light and to possess two polarization states. Gravitational waves can interact with matter, allowing for their direct detection by means of laser interferometers. Finally, Einstein's quadrupole formulas are derived and used to show that nonspherical compact objects moving at relativistic speeds a...

  20. Deflagration Wave Profiles

    Energy Technology Data Exchange (ETDEWEB)

    Menikoff, Ralph [Los Alamos National Laboratory

    2012-04-03

    Shock initiation in a plastic-bonded explosives (PBX) is due to hot spots. Current reactive burn models are based, at least heuristically, on the ignition and growth concept. The ignition phase occurs when a small localized region of high temperature (or hot spot) burns on a fast time scale. This is followed by a growth phase in which a reactive front spreads out from the hot spot. Propagating reactive fronts are deflagration waves. A key question is the deflagration speed in a PBX compressed and heated by a shock wave that generated the hot spot. Here, the ODEs for a steady deflagration wave profile in a compressible fluid are derived, along with the needed thermodynamic quantities of realistic equations of state corresponding to the reactants and products of a PBX. The properties of the wave profile equations are analyzed and an algorithm is derived for computing the deflagration speed. As an illustrative example, the algorithm is applied to compute the deflagration speed in shock compressed PBX 9501 as a function of shock pressure. The calculated deflagration speed, even at the CJ pressure, is low compared to the detonation speed. The implication of this are briefly discussed.

  1. Developing de Broglie Wave

    Directory of Open Access Journals (Sweden)

    Zheng-Johansson J. X.

    2006-10-01

    Full Text Available The electromagnetic component waves, comprising together with their generating oscillatory massless charge a material particle, will be Doppler shifted when the charge hence particle is in motion, with a velocity v, as a mere mechanical consequence of the source motion. We illustrate here that two such component waves generated in opposite directions and propagating at speed c between walls in a one-dimensional box, superpose into a traveling beat wave of wavelength Λd=vcΛ and phase velocity c2/v+v which resembles directly L. de Broglie’s hypothetic phase wave. This phase wave in terms of transmitting the particle mass at the speed v and angular frequency Ωd= 2πv/Λd, with Λd and Ωd obeying the de Broglie relations, represents a de Broglie wave. The standing-wave function of the de Broglie (phase wave and its variables for particle dynamics in small geometries are equivalent to the eigen-state solutions to Schrödinger equation of an identical system.

  2. RELJEFI S PRIKAZIMA HERAKLOVIH DJELA U CRKVI SV. KAJA U SOLINU

    OpenAIRE

    Jeličić-Radonić, Jasna

    2005-01-01

    U crkvi sv. Kaja u Solinu nalazi se rimski "sarkofag" s prikazom Heraklovih djela, izvorno isklesan u litici unutar male spilje. Spomenik u obliku sanduka u neposrednoj blizini zapadne salonitanske nekropole bio je presudan da se u dosadašnjoj literaturi protumači kao antički sarkofag. Budući da je podzemni potok izvirao u spilji, a voda se skupljala u kamenom recipijentu s Heraklovim reljefima, odakle je otjecala, autorica prepoznaje Heraklovo svetište u prirodi. Tradicija o posvećenoj vodi ...

  3. CCD Photometry of Field RR Lyrae Stars. I. Period Changes of SV ERI and XX and

    Directory of Open Access Journals (Sweden)

    Jong-Myung Joo

    1996-06-01

    Full Text Available CCD time series photometry was performed for two Oosterhoff type II± field RR Lyrae stars, SV Eri and XX And, to construct light curves in B and V bands. The maximum light times from our observations were combined with those in the literature to construct phase shift diagrams, from which we determined the period change rates β. We obtained large positive period change rates for these stars, which are expected from current evolutionary models if these stars are evolving rapidly from blue to red toward the end of core helium burning phase.

  4. Data on Leptospira interrogans sv Pomona infection in Meat Workers in New Zealand

    Directory of Open Access Journals (Sweden)

    M. Pittavino

    2017-08-01

    A prospective cohort study was conducted in four sheep slaughtering abattoirs in New Zealand (NZ (Dreyfus et al., 2015 [1]. Sera were collected twice a year from 384 meat workers and tested by Microscopic Agglutination for Leptospira interrogans sv Pomona (Pomona infection, one of the most common Leptospira serovars in humans in NZ. This article provides an extended analysis of the data, illustrating the different steps of a multivariable (i.e. generalized linear model and especially a multivariate tool based on additive Bayesian networks (ABN modelling.

  5. Wave propagation and impact in composite materials

    Science.gov (United States)

    Moon, F. C.

    1975-01-01

    Anisotropic waves in composites are considered, taking into account wave speeds, wave surfaces, flexural waves in orthotropic plates, surface waves, edge waves in plates, and waves in coupled composite plates. Aspects of dispersion in composites are discussed, giving attention to pulse propagation and dispersion, dispersion in rods and plates, dispersion in a layered composite, combined material and structural dispersion, continuum theories for composites, and variational methods for periodic composites. The characteristics of attenuation and scattering processes are examined and a description is given of shock waves and impact problems in composites. A number of experiments are also reported.

  6. Estimating surface reflectance from Himawari-8/AHI reflectance channels Using 6SV

    Science.gov (United States)

    Lee, Kyeong-sang; Choi, Sungwon; Seo, Minji; Seong, Noh-hun; Han, Kyung-soo

    2017-04-01

    TOA (Top Of Atmospheric) reflectance observed by satellite is modified by the influence of atmosphere such as absorbing and scattering by molecular and gasses. Removing TOA reflectance attenuation which is caused by the atmospheric is essential. surface reflectance with compensated atmospheric effects used as important input data for land product such as Normalized Difference Vegetation Index (NDVI), Land Surface Albedo (LSA) and etc. In this study, we Second Simulation of a Satellite Signal in the Solar Spectrum Vector (6SV) Radiative Transfer Model (RTM) for atmospheric correction and estimating surface reflectance from Himawari-8/Advanced Himawari Imager (AHI) reflectance channels. 6SV has the advantage that it has high accuracy by performing the atmospheric correction by dividing the width of the satellite channel by 2.5 nm, but it is slow to use in the operation. So, we use LUT approach to reduce the computation time and avoid the intensive calculation required for retrieving surface reflectance. Estimated surface reflectance data were compared with PROBA-V S1 data to evaluate the accuracy. As a result Root Mean Square Error (RMSE) and bias were about 0.05 and -0.02. It is considered that this error is due to the difference of angle component and Spectral Response Function (SRF) of each channel.

  7. Aplikace svítivých diod v osvětlovací technice

    OpenAIRE

    Kolář, Pavel

    2010-01-01

    Bakalářská práce pojednává o základních principech LED zdrojů a jejich napájení, charakteristice těchto zdrojů ve vztahu k aplikaci ve svítidlech, dále pak o možnostech aplikace\\break v praxi a ekonomickému přínosu LED technologie. K tomuto tématu je čerpáno z převážně internetových zdrojů a to proto, že výrobci a distributoři osvětlovací techniky na bázi LED jako jsou například firmy Osram, Siteco, Philips, Bergquist, Cree, LEDfield a další poskytují na svých internetových stránkách dostateč...

  8. Rayleigh and Love waves incompatibility in the Pacific Ocean

    Energy Technology Data Exchange (ETDEWEB)

    Canas, J.A.; Pujadses, L.; Egozcue, J.J.; Rodellar, J. Barbat, A.

    1988-01-01

    The polarization anisotropy is investigated in the whole Pacific Ocean. Generalized inversion applied to Rayleigh and Love waves separately, show inconsistency between SH and SV velocities. A direct method that considers the media being anisotropic yields a shear-wave velocity model in which the anisotropy is constrained to the lithosphere. The inconsistency in the asthenosphere seems to be very small for the period range of this study (18 to 100 seconds).

  9. Run-up on a structure due to second-order waves and current in a numerical wave tank

    DEFF Research Database (Denmark)

    Buchmann, Bjarne; Skourup, Jesper; Cheung, Kwok Fai

    1998-01-01

    order in current speed. The boundary-value problem is separated into a known incident wave field and an unknown scattered wave field, the latter being absorbed at the radiation boundaries using active wave absorption. The present paper focuses on the wave run-up on a structure in waves and current...

  10. Wind speed, wind direction, air temperature, wave energy spectra, significant wave height, dominant wave period and direction, peak wave period and direction, currents, temperature, conductivity, pressure, sigma-theta, river level, sonar readings, and backscatter data collected at Myrtle Beach in the North Atlantic Ocean from instruments deployed on MOORINGS using platforms NOAA Ship NANCY FOSTER and RV DAN MOORE from 2003-10-01 to 2004-05-01 (NODC Accession 0066109)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These bottom current, wave and associated observations were collected as part of a larger study to understand the physical processes that control the transport of...

  11. Epilepsy caused by an abnormal alternative splicing with dosage effect of the SV2A gene in a chicken model.

    Directory of Open Access Journals (Sweden)

    Marine Douaud

    Full Text Available Photosensitive reflex epilepsy is caused by the combination of an individual's enhanced sensitivity with relevant light stimuli, such as stroboscopic lights or video games. This is the most common reflex epilepsy in humans; it is characterized by the photoparoxysmal response, which is an abnormal electroencephalographic reaction, and seizures triggered by intermittent light stimulation. Here, by using genetic mapping, sequencing and functional analyses, we report that a mutation in the acceptor site of the second intron of SV2A (the gene encoding synaptic vesicle glycoprotein 2A is causing photosensitive reflex epilepsy in a unique vertebrate model, the Fepi chicken strain, a spontaneous model where the neurological disorder is inherited as an autosomal recessive mutation. This mutation causes an aberrant splicing event and significantly reduces the level of SV2A mRNA in homozygous carriers. Levetiracetam, a second generation antiepileptic drug, is known to bind SV2A, and SV2A knock-out mice develop seizures soon after birth and usually die within three weeks. The Fepi chicken survives to adulthood and responds to levetiracetam, suggesting that the low-level expression of SV2A in these animals is sufficient to allow survival, but does not protect against seizures. Thus, the Fepi chicken model shows that the role of the SV2A pathway in the brain is conserved between birds and mammals, in spite of a large phylogenetic distance. The Fepi model appears particularly useful for further studies of physiopathology of reflex epilepsy, in comparison with induced models of epilepsy in rodents. Consequently, SV2A is a very attractive candidate gene for analysis in the context of both mono- and polygenic generalized epilepsies in humans.

  12. Vectors bicistronically linking a gene of interest to the SV40 large T antigen in combination with the SV40 origin of replication enhance transient protein expression and luciferase reporter activity.

    Science.gov (United States)

    Mahon, Matthew J

    2011-08-01

    The simian virus 40 large T antigen (SVLT) induces replication of plasmids bearing the SV40 origin of replication (SV40 ori) within mammalian cells. The internal ribosomal entry site (IRES) is an element that allows for the cotranslation of proteins from one polycistronic mRNA. Through the combination of these elements, IRES-dependent coexpression of a protein of interest and the SVLT, either constitutive or regulated, on plasmids bearing the SV40 ori generates a positive feedback loop, resulting in enhanced expression. A vector linking red fluorescent protein (RFP) to the IRES-SVLT element enhances fluorescence ~10-fold over that demonstrated from a vector lacking this element. In transfection-resistant CV-1 cells, the RFP-IRES-SVLT vector substantially increases the number of cells expressing detectable levels of RFP. Furthermore, inclusion of the IRES-SVLT/SV40 ori elements in standard luciferase-based reporter gene constructs and associated effectors results in marked increases in luminescent output and sensitivity, using the β-catenin/TCF pathway and the mammalian two-hybrid assay as models. Ultimately, vector systems combining these well-established elements (IRES-SVLT/SV40 ori) will increase the utility of transient transfection for the production of recombinant proteins, the use of transfection-resistant cell lines, and the effectiveness of luciferase-based high-throughput screening assays.

  13. High speed data converters

    CERN Document Server

    Ali, Ahmed MA

    2016-01-01

    This book covers high speed data converters from the perspective of a leading high speed ADC designer and architect, with a strong emphasis on high speed Nyquist A/D converters. For our purposes, the term 'high speed' is defined as sampling rates that are greater than 10 MS/s.

  14. Quantum Emulation of Gravitational Waves.

    Science.gov (United States)

    Fernandez-Corbaton, Ivan; Cirio, Mauro; Büse, Alexander; Lamata, Lucas; Solano, Enrique; Molina-Terriza, Gabriel

    2015-07-14

    Gravitational waves, as predicted by Einstein's general relativity theory, appear as ripples in the fabric of spacetime traveling at the speed of light. We prove that the propagation of small amplitude gravitational waves in a curved spacetime is equivalent to the propagation of a subspace of electromagnetic states. We use this result to propose the use of entangled photons to emulate the evolution of gravitational waves in curved spacetimes by means of experimental electromagnetic setups featuring metamaterials.

  15. Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts

    Directory of Open Access Journals (Sweden)

    Easton Marilyn J

    2010-02-01

    Full Text Available Abstract Background Simian Virus 40 (SV40 immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC has been used to elicit tumors in athymic mice. 3-MC carcinogenesis has been thoroughly studied, however gene-level interactions between 3-MC and SV40 that could have produced the observed tumors have not been explored. The commercially-available human uroepithelial cell lines were either SV40-immortalized (HUC or SV40-immortalized and then 3-MC-transformed (HUC-TC. Results To characterize the SV40 - 3MC interaction, we compared human gene expression in these cell lines using a human cancer array and confirmed selected changes by RT-PCR. Many viral Large T Antigen (Tag expression-related changes occurred in HUC-TC, and it is concluded that SV40 and 3-MC may act synergistically to transform cells. Changes noted in IFP 9-27, 2'-5' OAS, IF 56, MxA and MxAB were typical of those that occur in response to viral exposure and are part of the innate immune response. Because interferon is crucial to innate immune host defenses and many gene changes were interferon-related, we explored cellular growth responses to exogenous IFN-γ and found that treatment impeded growth in tumor, but not immortalized HUC on days 4 - 7. Cellular metabolism however, was inhibited in both cell types. We conclude that IFN-γ metabolic responses were functional in both cell lines, but IFN-γ anti-proliferative responses functioned only in tumor cells. Conclusions Synergism of SV40 with 3-MC or other environmental carcinogens may be of concern as SV40 is now endemic in 2-5.9% of the U.S. population. In addition, SV40-immortalization is a generally-accepted method used in many research materials, but the possibility of off-target effects in studies carried out using these cells has not been considered. We hope that our work will stimulate further study of this important phenomenon.

  16. Travelling waves in the lattice epidemic model

    Directory of Open Access Journals (Sweden)

    Zhixian Yu

    2010-07-01

    Full Text Available In this article, we establish the existence and nonexistence of travelling waves for a lattice non-monotone integral equation which is an epidemic model. Moreover, the wave is either convergent to the positive equilibrium or oscillating on the positive equilibrium at positive infinity, and has the exponential asymptotic behavior at negative infinity. For the non-monotone case, the asymptotic speed of propagation also coincides with the minimal wave speed.

  17. Age-related changes in the motricity of the inbred mice strains 129/sv and C57BL/6j.

    Science.gov (United States)

    Serradj, Najet; Jamon, Marc

    2007-02-12

    The development of motor skills was studied at different stages in the life of the mouse, focusing on three key aspects of motor development: early rhythmic motor activities prior to the acquisition of quadruped locomotion, motor skills in young adults, and the effect of aging on motor skills. The age-related development pattern was analysed and compared in two strains of major importance for genomic studies (C57Bl6/j and 129/sv). Early rhythmic air-stepping activities by l-dopa injected mice showed similar overall development in both strains; differences were observed with greater beating frequency and less inter-limb coordination in 129/sv, suggesting that 129/sv had a different maturation process. Performance on the rotarod by young adult C57Bl6/j gradually improved between 1 and 3 months, but then declined with age; performance on the treadmill also declined with an age-related increase in fatigability. Overall performance by 129/sv mice was lower than C57Bl6/j, and the age-related pattern of change was different, with 129/sv having relatively stable performance over time. Inter-strain differences and their possible causes, in particular the role of dopaminergic pathways, are discussed together with repercussions affecting mutant phenotyping procedures.

  18. Airfoil shape for flight at subsonic speeds

    Science.gov (United States)

    Whitcomb, Richard T.

    1976-01-01

    An airfoil having an upper surface shaped to control flow accelerations and pressure distribution over the upper surface and to prevent separation of the boundary layer due to shock wave formulation at high subsonic speeds well above the critical Mach number. A highly cambered trailing edge section improves overall airfoil lifting efficiency.

  19. Wind Speed Measurement by Paper Anemometer

    Science.gov (United States)

    Zhong, Juhua; Cheng, Zhongqi; Guan, Wenchuan

    2011-01-01

    A simple wind speed measurement device, a paper anemometer, is fabricated based on the theory of standing waves. In providing the working profile of the paper anemometer, an experimental device is established, which consists of an anemometer sensor, a sound sensor, a microphone, paper strips, a paper cup, and sonic acquisition software. It shows…

  20. Cytopathic effect of Human cosavirus (HCoSV) on primary cell cultures of human embryonic lung MRC5.

    Science.gov (United States)

    Rezig, Dorra; Touzi, Henda; Meddeb, Zina; Triki, Henda

    2014-10-01

    Human cosaviruses (HCoSVs) are newly discovered viruses in Picornaviridae family. Until now, most published studies reported HCoSV detection using molecular techniques and genetic characterization of the virus. Nevertheless, no laboratory has yet reported the replication of these viruses in cultured cell lines. In the present work, the propagation of HCoSV strains isolated from human fecal specimens in MRC5 cell line and their induced cytopathic effects (CPE) was studied. The first sign of virus growth was observed 24-48h after inoculation. The cells rounded up and clumped together rapidly; empty areas became visible and, on the third day of CPE, a remarkable decrease in live cells was observed. This represents the first report on in vitro model of HCoSV replication which opens up opportunities for future investigations of these new viruses. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Waves from Propulsion Systems of Fast Ferries

    DEFF Research Database (Denmark)

    Taatø, Søren Haugsted; Aage, Christian; Arnskov, Michael M.

    1998-01-01

    Waves from fast ferries have become an environmental problem of growing concern to the public. Fast ferries produce not only higher waves than conventional ships but also fundamentally different wave systems when they sail at supercritical speeds. Hitherto, ship waves have been considered as being...... similar to that of the hull alone, but with higher wave amplitudes. Conventional propellers will cause increased wave heights of about 10%, whereas water jets will cause increased wave heights of 20-40% as compared to those of the naked monohull....

  2. Stress wave focusing transducers

    Energy Technology Data Exchange (ETDEWEB)

    Visuri, S.R., LLNL

    1998-05-15

    Conversion of laser radiation to mechanical energy is the fundamental process behind many medical laser procedures, particularly those involving tissue destruction and removal. Stress waves can be generated with laser radiation in several ways: creation of a plasma and subsequent launch of a shock wave, thermoelastic expansion of the target tissue, vapor bubble collapse, and ablation recoil. Thermoelastic generation of stress waves generally requires short laser pulse durations and high energy density. Thermoelastic stress waves can be formed when the laser pulse duration is shorter than the acoustic transit time of the material: {tau}{sub c} = d/c{sub s} where d = absorption depth or spot diameter, whichever is smaller, and c{sub s} = sound speed in the material. The stress wave due to thermoelastic expansion travels at the sound speed (approximately 1500 m/s in tissue) and leaves the site of irradiation well before subsequent thermal events can be initiated. These stress waves, often evolving into shock waves, can be used to disrupt tissue. Shock waves are used in ophthalmology to perform intraocular microsurgery and photodisruptive procedures as well as in lithotripsy to fragment stones. We have explored a variety of transducers that can efficiently convert optical to mechanical energy. One such class of transducers allows a shock wave to be focused within a material such that the stress magnitude can be greatly increased compared to conventional geometries. Some transducer tips could be made to operate regardless of the absorption properties of the ambient media. The size and nature of the devices enable easy delivery, potentially minimally-invasive procedures, and precise tissue- targeting while limiting thermal loading. The transducer tips may have applications in lithotripsy, ophthalmology, drug delivery, and cardiology.

  3. Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis.

    Directory of Open Access Journals (Sweden)

    Joanna Lee

    Full Text Available The putative Major Facilitator Superfamily (MFS transporter, SV2A, is the target for levetiracetam (LEV, which is a successful anti-epileptic drug. Furthermore, SV2A knock out mice display a severe seizure phenotype and die after a few weeks. Despite this, the mode of action of LEV is not known at the molecular level. It would be extremely desirable to understand this more fully in order to aid the design of improved anti-epileptic compounds. Since there is no structure for SV2A, homology modelling can provide insight into the ligand-binding site. However, it is not a trivial process to build such models, since SV2A has low sequence identity to those MFS transporters whose structures are known. A further level of complexity is added by the fact that it is not known which conformational state of the receptor LEV binds to, as multiple conformational states have been inferred by tomography and ligand binding assays or indeed, if binding is exclusive to a single state. Here, we explore models of both the inward and outward facing conformational states of SV2A (according to the alternating access mechanism for MFS transporters. We use a sequence conservation analysis to help guide the homology modelling process and generate the models, which we assess further with Molecular Dynamics (MD. By comparing the MD results in conjunction with docking and simulation of a LEV-analogue used in radioligand binding assays, we were able to suggest further residues that line the binding pocket. These were confirmed experimentally. In particular, mutation of D670 leads to a complete loss of binding. The results shed light on the way LEV analogues may interact with SV2A and may help with the on-going design of improved anti-epileptic compounds.

  4. Explosive Products EOS: Adjustment for detonation speed and energy release

    Energy Technology Data Exchange (ETDEWEB)

    Menikoff, Ralph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-09-05

    Propagating detonation waves exhibit a curvature effect in which the detonation speed decreases with increasing front curvature. The curvature effect is due to the width of the wave profile. Numerically, the wave profile depends on resolution. With coarse resolution, the wave width is too large and results in a curvature effect that is too large. Consequently, the detonation speed decreases as the cell size is increased. We propose a modification to the products equation of state (EOS) to compensate for the effect of numerical resolution; i.e., to increase the CJ pressure in order that a simulation propagates a detonation wave with a speed that is on average correct. The EOS modification also adjusts the release isentrope to correct the energy release.

  5. Discovery and development of SV2A PET tracers: Potential for imaging synaptic density and clinical applications.

    Science.gov (United States)

    Mercier, Joel; Provins, Laurent; Valade, Anne

    2017-11-01

    Imaging synaptic density in vivo has promise for numerous research and clinical applications in the diagnosis and treatment monitoring of neurodegenerative and psychiatric diseases. Recent developments in the field of PET, such as SV2A human imaging with the novel tracers UCB-A, UCB-H and UCB-J, may help in realizing this potential and bring significant benefit for the patients suffering from these diseases. This review provides an overview of the most recent progress in the field of SV2A PET imaging, its potential for use as a biomarker of synaptic density and the future development areas. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Slow frictional waves

    Science.gov (United States)

    Viswanathan, Koushik; Sundaram, Narayan; Chandrasekar, Srinivasan

    Stick-slip, manifest as intermittent tangential motion between two dry solid surfaces, is a friction instability that governs diverse phenomena from automobile brake squeals to earthquakes. We show, using high-speed in situ imaging of an adhesive polymer interface, that low velocity stick-slip is fundamentally of three kinds, corresponding to passage of three different surface waves -- separation pulses, slip pulses and the well-known Schallamach waves. These waves, traveling much slower than elastic waves, have clear distinguishing properties. Separation pulses and Schallamach waves involve local interface separation, and propagate in opposite directions while slip pulses are characterized by a sharp stress front and do not display any interface detachment. A change in the stick-slip mode from separation to slip pulse is effected simply by increasing the normal force. Together, these three waves constitute all possible stick-slip modes in adhesive friction and are shown to have direct analogues in muscular locomotory waves in soft bodied invertebrates. A theory for slow wave propagation is also presented which is capable of explaining the attendant interface displacements, velocities and stresses.

  7. Modeling and inversion of PS-wave moveout asymmetry for tilted TI media: Part 1 - Horizontal TTI layer

    Digital Repository Service at National Institute of Oceanography (India)

    Dewangan, P.; Tsvankin, I.

    is elliptical H20849H9280 = H9254H20850. Because for elliptical media there is no SV-wave velocity anisotropy, the S-leg of the converted wave does not produce any moveout asymmetry. This means that the P-leg cannot cause the asymmetry either H20849see above...

  8. Speed management program plan.

    Science.gov (United States)

    2014-05-01

    Changing public attitudes regarding speeding and speed management will require a comprehensive and concerted effort, involving a wide variety of strategies. This plan identifies six primary focus areas: : A. Data and Data-Driven Approaches, : B. Rese...

  9. Chimeric SV40 virus-like particles induce specific cytotoxicity and protective immunity against influenza A virus without the need of adjuvants

    Energy Technology Data Exchange (ETDEWEB)

    Kawano, Masaaki [Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan); Morikawa, Katsuma [Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501 (Japan); Suda, Tatsuya [Department of Microbiology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan); Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan); Ohno, Naohito [Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan); Matsushita, Sho [Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan); Allergy Center, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan); Akatsuka, Toshitaka [Department of Microbiology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan); Handa, Hiroshi, E-mail: handa.h.aa@m.titech.ac.jp [Solutions Research Laboratory, Tokyo Institute of Technology, Midori-ku, Yokohama 226-8503 (Japan); Matsui, Masanori, E-mail: mmatsui@saitama-med.ac.jp [Department of Microbiology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495 (Japan)

    2014-01-05

    Virus-like particles (VLPs) are a promising vaccine platform due to the safety and efficiency. However, it is still unclear whether polyomavirus-based VLPs are useful for this purpose. Here, we attempted to evaluate the potential of polyomavirus VLPs for the antiviral vaccine using simian virus 40 (SV40). We constructed chimeric SV40-VLPs carrying an HLA-A{sup ⁎}02:01-restricted, cytotoxic T lymphocyte (CTL) epitope derived from influenza A virus. HLA-A{sup ⁎}02:01-transgenic mice were then immunized with the chimeric SV40-VLPs. The chimeric SV40-VLPs effectively induced influenza-specific CTLs and heterosubtypic protection against influenza A viruses without the need of adjuvants. Because DNase I treatment of the chimeric SV40-VLPs did not disrupt CTL induction, the intrinsic adjuvant property may not result from DNA contaminants in the VLP preparation. In addition, immunization with the chimeric SV40-VLPs generated long-lasting memory CTLs. We here propose that the chimeric SV40-VLPs harboring an epitope may be a promising CTL-based vaccine platform with self-adjuvant properties. - Highlights: • We constructed chimeric SV40-VLPs carrying an influenza virus-derived CTL epitope. • Chimeric SV40-VLPs induce influenza-specific CTLs in mice without adjuvants. • Chimeric SV40-VLPs induce heterosubtypic protection against influenza A viruses. • Chimeric SV40-VLPs induce long-lasting memory CTLs. • Chimeric SV40-VLPs is a promising vaccine platform with self-adjuvant properties.

  10. Turbulence generation by waves

    Energy Technology Data Exchange (ETDEWEB)

    Kaftori, D.; Nan, X.S.; Banerjee, S. [Univ. of California, Santa Barbara, CA (United States)

    1995-12-31

    The interaction between two-dimensional mechanically generated waves, and a turbulent stream was investigated experimentally in a horizontal channel, using a 3-D LDA synchronized with a surface position measuring device and a micro-bubble tracers flow visualization with high speed video. Results show that although the wave induced orbital motion reached all the way to the wall, the characteristics of the turbulence wall structures and the turbulence intensity close to the wall were not altered. Nor was the streaky nature of the wall layer. On the other hand, the mean velocity profile became more uniform and the mean friction velocity was increased. Close to the free surface, the turbulence intensity was substantially increased as well. Even in predominantly laminar flows, the introduction of 2-D waves causes three dimensional turbulence. The turbulence enhancement is found to be proportional to the wave strength.

  11. On-line high-speed rail defect detection.

    Science.gov (United States)

    2004-10-01

    This report presents the results of phase 2 of the project On-line high-speed rail defect detection aimed at improving the reliability and the speed of current defect detection in rails. Ultrasonic guided waves, traveling in the rail running di...

  12. Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies

    Directory of Open Access Journals (Sweden)

    Miguel G. Toscano

    2017-09-01

    Full Text Available Replication-defective (RD recombinant simian virus 40 (SV40-based gene delivery vectors hold a great potential for clinical applications because of their presumed non-immunogenicity and capacity to induce immune tolerance to the transgene products in humans. However, the clinical use of SV40 vectors has been hampered by the lack of a packaging cell line that produces replication-competent (RC free SV40 particles in the vector production process. To solve this problem, we have adapted the current SV40 vector genome used for the production of vector particles and generated a novel Vero-based packaging cell line named SuperVero that exclusively expresses the SV40 large T antigen. SuperVero cells produce similar numbers of SV40 vector particles compared to the currently used packaging cell lines, albeit in the absence of contaminating RC SV40 particles. Our unique SV40 vector platform named SVac paves the way to clinically test a whole new generation of SV40-based therapeutics for a broad range of important diseases.

  13. Use of 2sv-technology for thermal utilisation of biomass according to biomass regulation; Einsatz der 2sv-Technologie zur thermischen Verwertung von Biomasse gemaess der Biomasseverordnung

    Energy Technology Data Exchange (ETDEWEB)

    Nitsche, R. [Mitteldeutsche Feuerungs- und Umwelttechnik GmbH, Leipzig (Germany); Mallon, J. [Ingitec GmbH, Leipzig (Germany); Scheidig, K.

    2001-07-01

    The 2sv-procedure represents an economic alternative to energetic utilisation of biomass and to thermal utilisation of waste. Core piece of the new plant technology is the 2sv-reactor. The speciality of the process is the melting gasification of the used materials with technical oxygen. The metallurgic process technology that is well-known and proved from shaft furnaces is used and thus temperatures of up to 2000 degrees Celsius are reached in a reducing atmosphere. The generated fuel gas has the characteristics of synthesis gas. It is not only suitable for electric current generation in dual purpose power plants but also for the substitution of primary energy carriers in furnace plants. The company MFU GmbH Leipzig-Holzhausen delivers 2vs-plants in modular design for processing capacities of 10, 20 and 30 kt/a. (orig.) [German] Das 2sv-Verfahren stellt eine wirtschaftliche Alternative zur energetischen Nutzung von Biomassen wie auch zur thermischen Abfallverwertung dar. Herzstueck der neuen Anlagentechnik ist der 2sv-Reaktor. Die Besonderheiten des Prozesses bestehen in der Schmelzvergasung der Einsatzstoffe unter Einsatz von technischem Sauerstoff. Unter Nutzung der vom Schachtofen bekannten und bewaehrten metallurgischen Verfahrenstechnik werden dabei Temperaturen bis 2000 C in reduzierender Atmosphaere erreicht. Das erzeugte Brenngas besitzt Synthesegasqualitaet. Es ist sowohl zur Stromerzeugung im BHKW als auch zur Substitution von Primaerenergietraegern in Feuerungsanlagen geeignet. Die MFU GmbH Leipzig-Holzhausen liefert komplette 2sv-Anlagen in Modulbauweise fuer Verarbeitungskapazitaeten von 10, 30 und 50 kt/a. (orig.)

  14. One-mSv CT colonography: Effect of different iterative reconstruction algorithms on radiologists' performance.

    Science.gov (United States)

    Shin, Cheong-Il; Kim, Se Hyung; Im, Jong Pil; Kim, Sang Gyun; Yu, Mi Hye; Lee, Eun Sun; Han, Joon Koo

    2016-03-01

    To analyze the effect of different reconstruction algorithms on image noise and radiologists' performance at ultra-low dose CT colonography (CTC) in human subjects. This retrospective study had institutional review board approval, with waiver of the need to obtain informed consent. CTC and subsequent colonoscopy were performed at the same day in 28 patients. CTC was scanned at the supine/prone positions using 120/100kVp and fixed 10mAs, and reconstructed using filtered back projection (FBP), adaptive statistical iterative reconstruction (ASIR), and model-based IR (Veo) algorithms. Size-specific dose estimates (SSDE) and effective radiation doses were recorded. Image noise was compared among the three datasets using repeated measures analysis of variance (ANOVA). Per-polyp sensitivity and figure-of-merits were compared among the datasets using the McNemar test and jackknife alternative free-response receiver operating characteristic (JAFROC) analysis, respectively, by one novice and one expert reviewer in CTC. Mean SSDE and effective radiation dose of CTC were 1.732mGy and 1.002mSv, respectively. Mean image noise at supine/prone position datasets was significantly lowest with Veo (17.2/13.3), followed by ASIR (52.4/38.9) and FBP (69.9/50.8) (Preconstruction (81.0%, 64.3%), followed by ASIR (73.8%, 54.8%) and FBP (57.1%, 50.0%) with statistical significance between Veo and FBP for reader 1 (P=0.002). JAFROC analysis revealed that the figure-of-merit for the detection of polyps was highest with Veo (0.917, 0.786), followed by ASIR (0.881, 0.750) and FBP (0.750, 0.746) with statistical significances between Veo or ASIR and FBP for reader 1 (P<0.05). One-mSv CTC was not feasible using the standard FBP algorithm. However, diagnostic performance expressed as per-polyp sensitivity and figures-of-merit can be improved with the application of IR algorithms, particularly Veo. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  15. Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Zhuji; Chen, Chen; Barbieri, Joseph T.; Kim, Jung-Ja P.; Baldwin, Michael R.; (MCW)

    2010-02-22

    Botulinum neurotoxin causes rapid flaccid paralysis through the inhibition of acetylcholine release at the neuromuscular junction. The seven BoNT serotypes (A-G) have been proposed to bind motor neurons via ganglioside-protein dual receptors. To date, the structure-function properties of BoNT/F host receptor interactions have not been resolved. Here, we report the crystal structures of the receptor binding domains (HCR) of BoNT/A and BoNT/F and the characterization of the dual receptors for BoNT/F. The overall polypeptide fold of HCR/A is essentially identical to the receptor binding domain of the BoNT/A holotoxin, and the structure of HCR/F is very similar to that of HCR/A, except for two regions implicated in neuronal binding. Solid phase array analysis identified two HCR/F binding glycans: ganglioside GD1a and oligosaccharides containing an N-acetyllactosamine core. Using affinity chromatography, HCR/F bound native synaptic vesicle glycoproteins as part of a protein complex. Deglycosylation of glycoproteins using {alpha}(1-3,4)-fucosidase, endo-{beta}-galactosidase, and PNGase F disrupted the interaction with HCR/F, while the binding of HCR/B to its cognate receptor, synaptotagmin I, was unaffected. These data indicate that the HCR/F binds synaptic vesicle glycoproteins through the keratan sulfate moiety of SV2. The interaction of HCR/F with gangliosides was also investigated. HCR/F bound specifically to gangliosides that contain {alpha}2,3-linked sialic acid on the terminal galactose of a neutral saccharide core (binding order GT1b = GD1a GM3; no binding to GD1b and GM1a). Mutations within the putative ganglioside binding pocket of HCR/F decreased binding to gangliosides, synaptic vesicle protein complexes, and primary rat hippocampal neurons. Thus, BoNT/F neuronal discrimination involves the recognition of ganglioside and protein (glycosylated SV2) carbohydrate moieties, providing a structural basis for the high affinity and specificity of BoNT/F for neurons.

  16. Electromagnetic Waves

    DEFF Research Database (Denmark)

    This book is dedicated to various aspects of electromagnetic wave theory and its applications in science and technology. The covered topics include the fundamental physics of electromagnetic waves, theory of electromagnetic wave propagation and scattering, methods of computational analysis...

  17. Dual Waves

    OpenAIRE

    Kallosh, Renata

    1994-01-01

    We study the gravitational waves in the 10-dimensional target space of the superstring theory. Some of these waves have unbroken supersymmetries. They consist of Brinkmann metric and of a 2-form field. Sigma-model duality is applied to such waves. The corresponding solutions we call dual partners of gravitational waves, or dual waves. Some of these dual waves upon Kaluza-Klein dimensional reduction to 4 dimensions become equivalent to the conformo-stationary solutions of axion-dilaton gravity...

  18. Reinterpretation of Matter-Wave Interference Experiments Based on the Local-Ether Wave Equation

    OpenAIRE

    Su, Ching-Chuan

    2002-01-01

    Based on the local-ether wave equation for free particle, the dispersion of matter wave is examined. From the dispersion relation, the angular frequency and wavelength of matter wave are derived. These formulas look like the postulates of de Broglie in conjunction with the Lorentz mass-variation law. However, the fundamental difference is that for terrestrial particles their speeds are referred specifically to a geocentric inertial frame and hence incorporate the speed due to earth's rotation...

  19. Sigma Virus (DMelSV Incidence in Lines of Drosophila melanogaster Selected for Survival following Infection with Bacillus cereus

    Directory of Open Access Journals (Sweden)

    Meghan L. Bentz

    2017-01-01

    Full Text Available The immune response of Drosophila melanogaster is complex and involves both specific and general responses to parasites. In this study we tested for cross-immunity for bacteria and viruses by scoring the incidence of infection with the vertically transmitted Sigma virus (DMelSV in the progeny of a cross between females transmitting DMelSV at high frequencies and males from lines subjected to three selection regimes related to resistance to Bacillus cereus. There was no significant difference in transmission of DMelSV among selection regimes, though results suggest that the B. cereus selected lines had lower rates of infection by DMelSV. We found a significant difference in viral infection with respect to the sex of the progeny, with males consistently less likely to be infected than females. Given a finite energy budget, flies that have experienced immune system challenge may show alterations in other life history traits. Later eclosing progeny were also less likely to be infected than earlier eclosing progeny, indicating a relationship with development time. Finally, there was a significant interaction between the timing of collection and the sex of the progeny, such that later eclosing males were the most resistant group. Increased development time is sometimes associated with increased energy acquisition; from this perspective, increased development time may be associated with acquiring sufficient resources for effective resistance.

  20. Identification of potential drug targets in Salmonella enterica sv. Typhimurium using metabolic modelling and experimental validation

    DEFF Research Database (Denmark)

    Hartman, Hassan B.; Fell, David A.; Rossell, Sergio

    2014-01-01

    Salmonella enterica sv. Typhimurium is an established model organism for Gram-negative, intracellular pathogens. Owing to the rapid spread of resistance to antibiotics among this group of pathogens, new approaches to identify suitable target proteins are required. Based on the genome sequence of ...

  1. An acoustic wave equation for pure P wave in 2D TTI media

    KAUST Repository

    Zhan, Ge

    2011-01-01

    In this paper, a pure P wave equation for an acoustic 2D TTI media is derived. Compared with conventional TTI coupled equations, the resulting equation is unconditionally stable due to the complete isolation of the SV wave mode. To avoid numerical dispersion and produce high quality images, the rapid expansion method REM is employed for numerical implementation. Synthetic results validate the proposed equation and show that it is a stable algorithm for modeling and reverse time migration RTM in a TTI media for any anisotropic parameter values. © 2011 Society of Exploration Geophysicists.

  2. Collation of offshore wind‐wave dynamics

    DEFF Research Database (Denmark)

    Bredmose, Henrik; Larsen, Søren Ejling; Matha, D.

    2012-01-01

    The present report constitutes the Protocol Manual for ensuring harmonisation of offshore wind and wave simulation being implemented at MaRINET facilities. Wind and wave climates for five offshore wind sites in the North Sea and the Baltic Sea have been presented in terms of probability...... distributions for wind speed along with a series of lumped sea states and turbulence intensity values, parameterised with respect to the wind speed. Further, extreme values for wind speed and significant wave height have been provided. Further to the wind distributions and lumped characteristics, the Weibull...... parameters for the wind distribution and explicit formulas for the turbulence intensity and significant wave height are provided. For the correlation of wave peak period and significant wave height, a standard formula from the IEC‐61400‐3 code have been found to cover the scatter in the data, although one...

  3. Speed in Acquisitions

    DEFF Research Database (Denmark)

    Meglio, Olimpia; King, David R.; Risberg, Annette

    2017-01-01

    The advantage of speed is often invoked by academics and practitioners as an essential condition during post-acquisition integration, frequently without consideration of the impact earlier decisions have on acquisition speed. In this article, we examine the role speed plays in acquisitions across...... the acquisition process using research organized around characteristics that display complexity with respect to acquisition speed. We incorporate existing research with a process perspective of acquisitions in order to present trade-offs, and consider the influence of both stakeholders and the pre......-deal-completion context on acquisition speed, as well as the organization’s capabilities to facilitating that speed. Observed trade-offs suggest both that acquisition speed often requires longer planning time before an acquisition and that associated decisions require managerial judgement. A framework for improving...

  4. Musikterapi med børn med svær autisme - en litteraturgennemgang

    Directory of Open Access Journals (Sweden)

    Ulla Holck

    2003-03-01

    Full Text Available Faglitteratur om musikterapi med børn med autisme er omfattende og indeholder såvel kvalitative case-beskrivelser som kvantitative forskningsundersøgelser. I artiklen gennemgås faglitteraturen systematisk med henblik på at specifi cere musikterapiens effekt og virkemåder i forhold til denne målgruppe. Vægten ligger på børn med svær autisme, men litteratur om voksne højtfungerende personer med autisme inddrages også. Forskningslitteraturen viser, at det især er inden for områderne koncentration, visuel opmærksomhed, respons og initiativ, samt brug af stemme og tur-tagning, at musikterapi har en effekt. Case-litteraturen begrunder denne effekt med musikkens evne til at være redundant, anvendelse af imitation og responsfremmende teknikker (overraskelse etc., fælles opbyggede samspilsformer, samt det temporale-interaktive element i improvisatorisk musikterapi. Ud fra en interaktionsteoretisk indfaldsvinkel sammenkobles effekten endvidere med, at den musikalske interaktion hjælper musikterapeuten til at fastholde et dynamisk udtryk, hvilket er afgørende i forhold til en klientgruppe, der ofte giver ´flad´ eller stærkt afvigende feedback.

  5. A human corneal equivalent constructed from SV40-immortalised corneal cell lines.

    Science.gov (United States)

    Zorn-Kruppa, Michaela; Tykhonova, Svitlana; Belge, Gazanfer; Bednarz, Jürgen; Diehl, Horst A; Engelke, Maria

    2005-02-01

    Within the last decade, extensive research in the field of tissue and organ engineering has focused on the development of in vitro models of the cornea. The use of organotypic, three-dimensional corneal equivalents has several advantages over simple monolayer cultures. The aim of this study was to develop a corneal equivalent model composed of the same cell types as in the natural human tissue, but by using immortalised cell lines to ensure reproducibility and to minimise product variation. We report our success in the establishment of an SV40-immortalised human corneal keratocyte cell line (designated HCK). A collagen matrix, built up with these cells, displayed the morphological characteristics of the human stromal tissue and served as a biomatrix for the immortalised human corneal epithelial and endothelial cells. Histological cross-sections of the whole-cornea equivalents resemble human corneas in tissue structure. This organotypic in vitro model may serve as a research tool for the ophthalmic science community, as well as a model system for testing for eye irritancy and drug efficacy.

  6. SV40-transformed human corneal keratocytes: optimisation of serum-free culture conditions.

    Science.gov (United States)

    Manzer, Anna Katharina; Lombardi-Borgia, Simone; Schäfer-Korting, Monika; Seeber, Judith; Zorn-Kruppa, Michaela; Engelke, Maria

    2009-01-01

    Aiming at the replacement of animal experiments in eye irritation testing, we have established a multilay ered cornea model comprising the co-culture of all three corneal cell types. It was the objective of this study to optimise serum-free culture conditions to preserve both growth and phenotype of an SV40-immortalised human corneal keratocyte cell line (HCK). Our results revealed that HCK continue to proliferate in both monolayer cultures as well as after seeding in a collagen matrix and resemble primary corneal keratocytes in morphology and functional characteristics under defined serum-free conditions. Furthermore, HCK were shown to transform into activated corneal fibroblast phenotypes in response to serum and TGF(beta)1. In summary, HCK cells mimic their in vivo (primary) precursors, both in sustaining the quiescent keratocyte phenotype (serum-starved conditions) and in responding to growth factor stimulation. Hence, this cell line may provide a useful tool to study the toxicity and wound healing response of corneal keratocytes in vitro.

  7. DYNAMIC INFLUENCE CAUSED BY CLOSE BLASTING ON PRIMARY AND SECONDARY SUPPORT SYSTEM IN TUNNEL "SV. ROK"

    Directory of Open Access Journals (Sweden)

    Zvonimir Ester

    2003-12-01

    Full Text Available At the construction site of the road tunnel Sv. Rok, the second, left tunnels tube is being constructed parallel to the unfinished right tunnel. The part of right tunnel tube is supported with primary support system according to NAMT, the second part is supported complete with concrete. Distance between axes of the tunnel tubes is approximately 35 m. Drifting of the left tube is being done by blasting. A potential problem of damaging the surrounding rock and support system was recognized. It is well known that the ground vibration particle velocity due to a blast is a measure of damage on the nearby construction. The three component seismographs were used to measure ground oscillation velocities in the right tunnel tube. Total of 30 measurements were executed and 720 values were processed (including all three component oscillation velocities. Maximum ground oscillation velocity recorded was 232.061 mm/s. This paper brings conclusion derived from monitoring data achieved at close proximity to the blasting area, damage level criteria for the rock mass and support system and discusses how these results could assist further development in the control of blasting technique.

  8. Abrogation of p53-mediated transactivation by SV40 large T antigen.

    Science.gov (United States)

    Segawa, K; Minowa, A; Sugasawa, K; Takano, T; Hanaoka, F

    1993-03-01

    p53 is known to bind specifically to the 44-bp human DNA sequence in an immunoprecipitation assay. We show here that the transcription of the reporter CAT gene linked with the herpesvirus thymidine kinase (tk) promoter containing the 44-base sequence is enhanced by mouse wild-type but not mutant-type p53 in F9 and p53-null Saos-2 cells. The p53-mediated transactivation was dramatically abrogated by introduction of SV40 large T antigen (SVLT) in Saos-2 cells in which p53 was clearly associated with SVLT. Furthermore, the p53-SVLT complex did not bind to the 44-base sequence at all. Thus, SVLT sequesters the transactivation function of the wild-type p53 by inhibiting the binding of p53 to the 44-base sequence. This is good evidence to show 'loss of functions' in the product of a tumor-suppressor oncogene by a dominant oncogene product at a molecular level.

  9. SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products.

    Science.gov (United States)

    Sowd, Gregory A; Mody, Dviti; Eggold, Joshua; Cortez, David; Friedman, Katherine L; Fanning, Ellen

    2014-12-01

    Simian virus 40 (SV40) and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage. During SV40 DNA replication, ATM kinase activity prevents concatemerization of the viral genome whereas ATR activity prevents accumulation of aberrant genomes resulting from breakage of a moving replication fork as it converges with a stalled fork. However, the repair pathways that ATM and ATR orchestrate to prevent these aberrant SV40 DNA replication products are unclear. Using two-dimensional gel electrophoresis and Southern blotting, we show that ATR kinase activity, but not DNA-PK(cs) kinase activity, facilitates some aspects of double strand break (DSB) repair when ATM is inhibited during SV40 infection. To clarify which repair factors associate with viral DNA replication centers, we examined the localization of DSB repair proteins in response to SV40 infection. Under normal conditions, viral replication centers exclusively associate with homology-directed repair (HDR) and do not colocalize with non-homologous end joining (NHEJ) factors. Following ATM inhibition, but not ATR inhibition, activated DNA-PK(cs) and KU70/80 accumulate at the viral replication centers while CtIP and BLM, proteins that initiate 5' to 3' end resection during HDR, become undetectable. Similar to what has been observed during cellular DSB repair in S phase, these data suggest that ATM kinase influences DSB repair pathway choice by preventing the recruitment of NHEJ factors to replicating viral DNA. These data may explain how ATM prevents concatemerization of the viral genome and promotes viral propagation. We suggest that inhibitors of DNA damage signaling and DNA repair could be used during infection to disrupt productive viral DNA replication.

  10. SV40 Infection of Mesenchymal Stromal Cells From Wharton's Jelly Drives the Production of Inflammatory and Tumoral Mediators.

    Science.gov (United States)

    Cason, Carolina; Campisciano, Giuseppina; Zanotta, Nunzia; Valencic, Erica; Delbue, Serena; Bella, Ramona; Comar, Manola

    2017-11-01

    The Mesenchymal Stromal Cells from umbilical cord Wharton's jelly (WJSCs) are a source of cells with high potentiality for the treatment of human immunological disorders. Footprints of the oncogenic viruses Simian Virus 40 (SV40) and JC Virus (JCPyV) have been recently detected in human WJSCs specimens. The aim of this study is to evaluate if WJSCs can be efficiently infected by these Polyomaviruses and if they can potentially exert tumoral activity. Cell culture experiments indicated that WJSCs could sustain both SV40 and JCPyV infections. A transient and lytic replication was observed for JCPyV, while SV40 persistently infected WJSCs over a long period of time, releasing a viral progeny at low titer without evident cytopathic effect (CPE). Considering the association between SV40 and human tumors and the reported ability of the oncogenic viruses to drive the host innate immune response to cell transformation, the expression profile of a large panel of immune mediators was evaluated in supernatants by the Bioplex platform. RANTES, IL-3, MIG, and IL-12p40, involved in chronic inflammation, cells differentiation, and transformation, were constantly measured at high concentration comparing to control. These findings represent a new aspect of SV40 biological activity in the humans, highlighting its interaction with specific host cellular pathways. In view of these results, it seems to be increasingly urgent to consider Polyomaviruses in the management of WJSCs for their safely use as promising therapeutic source. J. Cell. Physiol. 232: 3060-3066, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  11. SV40 Utilizes ATM Kinase Activity to Prevent Non-homologous End Joining of Broken Viral DNA Replication Products

    Science.gov (United States)

    Sowd, Gregory A.; Mody, Dviti; Eggold, Joshua; Cortez, David; Friedman, Katherine L.; Fanning, Ellen

    2014-01-01

    Simian virus 40 (SV40) and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage. During SV40 DNA replication, ATM kinase activity prevents concatemerization of the viral genome whereas ATR activity prevents accumulation of aberrant genomes resulting from breakage of a moving replication fork as it converges with a stalled fork. However, the repair pathways that ATM and ATR orchestrate to prevent these aberrant SV40 DNA replication products are unclear. Using two-dimensional gel electrophoresis and Southern blotting, we show that ATR kinase activity, but not DNA-PKcs kinase activity, facilitates some aspects of double strand break (DSB) repair when ATM is inhibited during SV40 infection. To clarify which repair factors associate with viral DNA replication centers, we examined the localization of DSB repair proteins in response to SV40 infection. Under normal conditions, viral replication centers exclusively associate with homology-directed repair (HDR) and do not colocalize with non-homologous end joining (NHEJ) factors. Following ATM inhibition, but not ATR inhibition, activated DNA-PKcs and KU70/80 accumulate at the viral replication centers while CtIP and BLM, proteins that initiate 5′ to 3′ end resection during HDR, become undetectable. Similar to what has been observed during cellular DSB repair in S phase, these data suggest that ATM kinase influences DSB repair pathway choice by preventing the recruitment of NHEJ factors to replicating viral DNA. These data may explain how ATM prevents concatemerization of the viral genome and promotes viral propagation. We suggest that inhibitors of DNA damage signaling and DNA repair could be used during infection to disrupt productive viral DNA replication. PMID:25474690

  12. SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products.

    Directory of Open Access Journals (Sweden)

    Gregory A Sowd

    2014-12-01

    Full Text Available Simian virus 40 (SV40 and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage. During SV40 DNA replication, ATM kinase activity prevents concatemerization of the viral genome whereas ATR activity prevents accumulation of aberrant genomes resulting from breakage of a moving replication fork as it converges with a stalled fork. However, the repair pathways that ATM and ATR orchestrate to prevent these aberrant SV40 DNA replication products are unclear. Using two-dimensional gel electrophoresis and Southern blotting, we show that ATR kinase activity, but not DNA-PK(cs kinase activity, facilitates some aspects of double strand break (DSB repair when ATM is inhibited during SV40 infection. To clarify which repair factors associate with viral DNA replication centers, we examined the localization of DSB repair proteins in response to SV40 infection. Under normal conditions, viral replication centers exclusively associate with homology-directed repair (HDR and do not colocalize with non-homologous end joining (NHEJ factors. Following ATM inhibition, but not ATR inhibition, activated DNA-PK(cs and KU70/80 accumulate at the viral replication centers while CtIP and BLM, proteins that initiate 5' to 3' end resection during HDR, become undetectable. Similar to what has been observed during cellular DSB repair in S phase, these data suggest that ATM kinase influences DSB repair pathway choice by preventing the recruitment of NHEJ factors to replicating viral DNA. These data may explain how ATM prevents concatemerization of the viral genome and promotes viral propagation. We suggest that inhibitors of DNA damage signaling and DNA repair could be used during infection to disrupt productive viral DNA replication.

  13. Replication of pSV2-gpt in COS-1 cells: stability of plasmid DNA in the presence and absence of biochemical selection.

    Science.gov (United States)

    Tsui, L C; Breitman, M L

    1985-03-01

    We have previously demonstrated that COS-1 cell lines transformed by pSV2-gpt and maintained under biochemical selection replicate multiple copies of extrachromosomal plasmid DNA (1). We have now examined the replication and stability of this DNA in a representative cell line. In situ hybridization analyses revealed that intense replication of pSV2-gpt occurs in only a small subpopulation of cells and results from bursts of plasmid replication that occur periodically and spontaneously in the cell population. This suggests that COS-1 cells are only semipermissive for pSV2-gpt replication. No correlation was observed between levels of pSV2-gpt replication and the presence or absence of biochemical selection for the Gpt marker. However, growth of cells under nonselective conditions led to a rapid and progressive loss of pSV2-gpt DNA. This loss correlated with segregation of Gpt- revertants that lacked detectable plasmid sequences. Hence, maintenance of pSV2-gpt in the cell line was dependent on continuous biochemical selection. Stable replication of pSV2-gpt could be observed as late as four months after transfection, suggesting that this system might be useful for propagation of cloned DNA in COS-1 cells for extended periods of time. However, by nine months, extensive rearrangements of pSV2-gpt sequences were detected, indicating ultimate instability of the plasmid in the host cells.

  14. Speed and income

    DEFF Research Database (Denmark)

    Fosgerau, Mogens

    2005-01-01

    The relationship between speed and income is established in a microeconomic model focusing on the trade-off between travel time and the risk of receiving a penalty for exceeding the speed limit. This is used to determine when a rational driver will choose to exceed the speed limit. The relationship...... between speed and income is found again in the empirical analysis of a cross-sectional dataset comprising 60,000 observations of car trips. This is used to perform regressions of speed on income, distance travelled, and a number of controls. The results are clearly statistically significant and indicate...... an average income elasticity of speed of 0.02; it is smaller at short distances and about twice as large at the longest distance investigated of 200 km....

  15. The detection of gravitational waves

    CERN Document Server

    Barish, Barry C

    1996-01-01

    General Relativity predicts the emission of gravitanional waves whenever compact concentrations of energy change shape. This could occur in a variety of astrophysical phenomena. For example, the coalescence of binary systems such as a pair of neutron stars or black holes emit gravitanional waves that propagate through space at the speed of light, and in principle, can be directly detected on the earth's surface. This lecture series will review the possible sources of gravitanional waves and the various approaches toward detection, with special emphasis on long baseline interferometer detectors. The Laser Interferometer Gravitanional Wave Observatory (LIGO) is being constructed with a goal to detect these waves and then to use them as a new tool to explore and study the Universe. The sources of gravitanional waves and techniques for detection will be presented, as well as the status and prospects for the LIGO project.

  16. Definition and evolution of a new symbiovar, sv. rigiduloides, among Ensifer meliloti efficiently nodulating Medicago species.

    Science.gov (United States)

    Gubry-Rangin, Cécile; Béna, Gilles; Cleyet-Marel, Jean-Claude; Brunel, Brigitte

    2013-10-01

    Understanding functional diversity is one of the main goals of microbial ecology, and definition of new bacterial ecotypes contributes significantly to this objective. Nitrogen-fixing bacteria provide a good system for investigation of ecotypes/biovars/symbiovars, as they present different specific associations with several host plants. This specific symbiosis is reflected both in the nodulation and fixation efficiency and in genetic characters of the bacteria, and several biovars have already been described in the bacterial species Ensifer meliloti. In the present study, the species affiliation of E. meliloti strains trapped from nodules sampled from Medicago rigiduloïdes roots was analyzed using housekeeping recA genes and DNA-DNA hybridization. The genetic diversity of these isolates was also investigated using several symbiotic markers: nodulation (nodA, nodB, nodC) and nitrogen fixation (nifH) genes, as well as the performance of phenotypic tests of nodulation capacity and nitrogen fixation efficiency. These analyses led to the proposal of a new bacterial symbiovar, E. meliloti sv. rigiduloides, that fixed nitrogen efficiently on M. rigiduloïdes, but not on Medicago truncatula. Using phylogenetic reconstructions, including the different described symbiovars, several hypotheses of lateral gene transfer and gene loss are proposed to explain the emergence of symbiovars within this species. The widespread geographical distribution of this symbiovar around the Mediterranean Basin, in contrast to restriction of M. rigiduloïdes to Eastern European countries, suggests that these isolates might also be associated with other plant species. The description of a new symbiovar within E. meliloti confirms the need for accurate bacterial ecological classification, especially for analysis of bacterial populations. Copyright © 2013 Elsevier GmbH. All rights reserved.

  17. Wave Height Distribution Observed by Ships in the North Atlantic

    DEFF Research Database (Denmark)

    Olsen, Anders Smærup; Schrøter, Carsten; Jensen, Jørgen Juncher

    2005-01-01

    The analysis of almost 25000 observation of the wave height from ships in the North Atlantic shows that the encountered wave height distribution is significantly lower than the distribution provided by the classification societies for structural assessment. The joint probability distribution...... for the significant wave height, the relative speed and the ship heading relative to the wave direction is given. This distribution shows that for higher waves the crews avoid sailing in following sea and as expected the speed is decreased in higher waves. There is, however, still a relatively high probability...

  18. On possible plume-guided seismic waves

    Science.gov (United States)

    Julian, B.R.; Evans, J.R.

    2010-01-01

    Hypothetical thermal plumes in the Earth's mantle are expected to have low seismic-wave speeds and thus would support the propagation of guided elastic waves analogous to fault-zone guided seismic waves, fiber-optic waves, and acoustic waves in the oceanic SOund Fixing And Ranging channel. Plume-guided waves would be insensitive to geometric complexities in the wave guide, and their dispersion would make them distinctive on seismograms and would provide information about wave-guide structure that would complement seismic tomography. Detecting such waves would constitute strong evidence of a new kind for the existence of plumes. A cylindrical channel embedded in an infinite medium supports two classes of axially symmetric elastic-wave modes, torsional and longitudinal-radial. Torsional modes have rectilinear particle motion tangent to the cylinder surface. Longitudinal-radial modes have elliptical particle motion in planes that include the cylinder axis, with retrograde motion near the axis. The direction of elliptical particle motion reverses with distance from the axis: once for the fundamental mode, twice for the first overtone, and so on. Each mode exists only above its cut-off frequency, where the phase and group speeds equal the shear-wave speed in the infinite medium. At high frequencies, both speeds approach the shear-wave speed in the channel. All modes have minima in their group speeds, which produce Airy phases on seismograms. For shear wave-speed contrasts of a few percent, thought to be realistic for thermal plumes in the Earth, the largest signals are inversely dispersed and have dominant frequencies of about 0.1-1 Hz and durations of 15-30 sec. There are at least two possible sources of observable plume waves: (1) the intersection of mantle plumes with high-amplitude core-phase caustics in the deep mantle; and (2) ScS-like reflection at the core-mantle boundary of downward-propagating guided waves. The widespread recent deployment of broadband

  19. Når det er svært at være ung i DK

    DEFF Research Database (Denmark)

    Nielsen, Jens Christian; Sørensen, Niels Ulrik

    Når det er svært at være ung i DK – viden og råd om unges trivsel og mistrivsel er afslutningen på et større forskningsprojekt om unges trivsel og mistrivsel. Hæftet præsenterer forskningsprojektets hovedkonklusioner og giver desuden en række råd og ideer til, hvordan voksne kan hjælpe unge med...... at håndtere mistrivsel. Hæftet er udarbejdet af forskerne Jens Christian Nielsen og Niels Ulrik Sørensen fra Center for Ungdomsforskning. Det er den sidste publikation i forskningsprojektet Når det er svært at være ung i DK, der fra 2008-2011 har belyst unges trivsel og mistrivsel. Projektet bygger både på en...

  20. Når det er svært at være ung i DK

    DEFF Research Database (Denmark)

    Nielsen, Jens Christian; Sørensen, Niels Ulrik; Grubb, Ane

    I rapporten Når det er svært at være ung i DK – unges beretninger om mistrivsel og ungdomsliv præsenteres resultaterne af et kvalitativt studie af mistrivsel og ungdomsliv blandt 15-24-årige unge i Danmark. Studiet bygger på dybdegående interviews med 33 unge fra forskellige dele af landet, der...... fortæller om deres erfaringer med diverse mistrivselsformer, som ensomhed, selvskadende adfærd og mobning, og om deres besvær med at håndtere de krav, udfordringer og muligheder, der i øvrigt præger det moderne ungdomsliv. Studiet indgår i det treårige forskningsprojekt Når det er svært at være ung i DK...

  1. MOĆI SV. IVANA – TROGIRSKI PALADIJ ZALOŽEN U ZADRU (FILIGRAN U RIZNICAMA DALMATINSKIH KATEDRALA)

    OpenAIRE

    Belamarić, Joško

    2000-01-01

    Koncem 14. stoljeća Trogirani bijahu prisiljeni založiti moćnik ruke svog zaštitnika u Zadar. Već 1399. odlučuju se ne samo otkupiti svoj moćnik i restaurirati ga, nego po izvornoj ruci naručiti novu u zadarskog zlatara Emerika Krenjića, koju on zbog smrti u lipnju 1400. nije dovršio. Izvorna ruka sv. Ivana Trogirskoga, koju je trebao kopirati, bila je remek-djelo mletačkog zlatarstva iz 1270-ih godina. Daju se i novi prijedlozi za datiranje filigrana na moćnicima ruku i glave sv. Vlaha u Dub...

  2. Torsional wave propagation in solar tornadoes

    Science.gov (United States)

    Vasheghani Farahani, S.; Ghanbari, E.; Ghaffari, G.; Safari, H.

    2017-03-01

    Aims: We investigate the propagation of torsional waves in coronal structures together with their collimation effects in the context of magnetohydrodynamic (MHD) theory. The interplay of the equilibrium twist and rotation of the structure, e.g. jet or tornado, together with the density contrast of its internal and external media is studied to shed light on the nature of torsional waves. Methods: We consider a rotating magnetic cylinder embedded in a plasma with a straight magnetic field. This resembles a solar tornado. In order to express the dispersion relations and phase speeds of the axisymmetric magnetohydrodynamic waves, the second-order thin flux tube approximation is implemented for the internal medium and the ideal MHD equations are implemented for the external medium. Results: The explicit expressions for the phase speed of the torsional wave show the modification of the torsional wave speed due to the equilibrium twist, rotation, and density contrast of the tornado. The speeds could be either sub-Alfvénic or ultra-Alfvénic depending on whether the equilibrium twist or rotation is dominant. The equilibrium twist increases the phase speed while the equilibrium rotation decreases it. The good agreement between the explicit versions for the phase speed and that obtained numerically proves adequate for the robustness of the model and method. The density ratio of the internal and external media also play a significant role in the speed and dispersion. Conclusions: The dispersion of the torsional wave is an indication of the compressibility of the oscillations. When the cylinder is rotating or twisted, in contrast to when it only possesses a straight magnetic field, the torsional wave is a collective mode. In this case its phase speed is determined by the Alfvén waves inside and outside the tornado.

  3. On the propagation speed of evanescent modes

    Energy Technology Data Exchange (ETDEWEB)

    Barbero, A.P.L. [State Univ. of Campinas, Campinas (Brazil)]|[Universidad Federal Fluminense (Brazil); Hernandez Figueroa, H.E. [State Univ. of Campinas, Campinas (Brazil); Recami, E. [Istituto Nazionale di Fisica Nucleare, Milan (Italy)]|[Bergamo Univ., Bergamo (Italy). Fac. di Ingegneria]|[State Univ. of Campinas, Campinas (Brazil)

    2000-03-01

    The group velocity of evanescent waves (in undersized waveguides, for instance) was theoretically predicted, and has been experimentally verified, to be superluminal. By contrast, it is known that the precursor speed in vacuum cannot be larger than c. This paper, by computer simulations based on Maxwell equations only, shows the existence of both phenomena and verifies the actual possibility of superluminal group velocities, without violating the so-called (naive) Einstein causality.

  4. Konstrukce genderové identity v seriálu Dokonalý svět

    OpenAIRE

    Mlynářová, Martina

    2014-01-01

    The thesis analyzes the instruments of gender stereotypes reproduction and gender identity construction in Czech TV series Dokonalý svět. Is the media content gendered? With which instruments of gender stereotypes reproduction and gender identity construction is TV viewer confronted and on which levels? I use the theory of social construction of reality, the theory of the lenses of gender or the characters and narrative structure of the TV series (soup opera) to come to a conclusion. The thes...

  5. Attempts on producing lymphoid cell line from Penaeus monodon by induction with SV40-T and 12S EIA oncogenes.

    Science.gov (United States)

    Puthumana, Jayesh; Prabhakaran, Priyaja; Philip, Rosamma; Singh, I S Bright

    2015-12-01

    In an attempt of in vitro transformation, transfection mediated expression of Simian virus-40 (T) antigen (SV40-T) and transduction mediated expression of Adenovirus type 12 early region 1A (12S E1A) oncogene were performed in Penaeus monodon lymphoid cells. pSV3-neo vector encoding SV40-T oncogene and a recombinant baculovirus BacP2-12S E1A-GFP encoding 12S E1A oncogene under the control of hybrid promoters were used. Electroporation and lipofection mediated transformation of SV40-T in lymphoid cells confirmed the transgene expression by phenotypic variation and the expression of GFP in co-transfection experiment. The cells transfected by lipofection (≥ 5%) survived for 14 days with lower toxicity (30%), whilst on electroporation, most of the cells succumbed to death (60%) and survived cells lived up to 7 days. Transduction efficiency in primary lymphoid cells was more than 80% within 14 days of post-transduction, however, an incubation period of 7 days post-transduction was observed without detectable expression of 12S E1A. High level of oncogenic 12S E1A expression were observed after 14 day post-transduction and the proliferating cells survived for more than 90 days with GFP expression, however, without in vitro transformation and immortalization. The study put forth the requirement of transduction mediated 'specific' oncogene expression along with telomerase activation and epigenetic induction for the immortalization and establishment of shrimp cell line. Copyright © 2015. Published by Elsevier Ltd.

  6. Når det er svært at være ung i DK

    DEFF Research Database (Denmark)

    Nielsen, Jens Christian; Sørensen, Niels Ulrik; Ozmec, Martha Nina

    det er svært at være ung i DK, som Center for Ungdomsforskning udfører med støtte fra Egmont Fonden. Rapporten bygger på telefoninterviews med 3.481 unge, der udgør et repræsentativt udsnit af alle 15-24-årige unge i Danmark. I rapporten forfølges de unges trivsel og mistrivsel gennem to spor: 1) Et...

  7. Effectiveness of Motorcycle speed controlled by speed hump

    Directory of Open Access Journals (Sweden)

    Pornsiri Urapa

    2014-09-01

    Full Text Available Speed humps are one of the traffic calming measures widely accepted to control vehicle speed in the local road. Humps standards from the western countries are designed mainly for the passenger car. This study, therefore, aims to reveal the effectiveness of speed hump to control the motorcycle speed. This study observes the free-flow speed of the riders at the total of 20 speed bumps and humps. They are 0.3-14.8 meter in width and 5-18 centimeter in height. The results reveal that the 85th percentile speeds reduce 15-65 percent when crossing the speed bumps and speed humps. Besides, this study develops the speed model to predict the motorcycle mean speed and 85th percentile speed. It is found that speed humps follow the ITE standard can control motorcycle crossing speeds to be 25-30 Kph which are suitable to travel on the local road.

  8. Body-wave traveltime and amplitude shifts from asymptotic travelling wave coupling

    Science.gov (United States)

    Pollitz, F.

    2006-01-01

    We explore the sensitivity of finite-frequency body-wave traveltimes and amplitudes to perturbations in 3-D seismic velocity structure relative to a spherically symmetric model. Using the approach of coupled travelling wave theory, we consider the effect of a structural perturbation on an isolated portion of the seismogram. By convolving the spectrum of the differential seismogram with the spectrum of a narrow window taper, and using a Taylor's series expansion for wavenumber as a function of frequency on a mode dispersion branch, we derive semi-analytic expressions for the sensitivity kernels. Far-field effects of wave interactions with the free surface or internal discontinuities are implicitly included, as are wave conversions upon scattering. The kernels may be computed rapidly for the purpose of structural inversions. We give examples of traveltime sensitivity kernels for regional wave propagation at 1 Hz. For the direct SV wave in a simple crustal velocity model, they are generally complicated because of interfering waves generated by interactions with the free surface and the Mohorovic??ic?? discontinuity. A large part of the interference effects may be eliminated by restricting the travelling wave basis set to those waves within a certain range of horizontal phase velocity. ?? Journal compilation ?? 2006 RAS.

  9. Plasma waves

    CERN Document Server

    Swanson, DG

    1989-01-01

    Plasma Waves discusses the basic development and equations for the many aspects of plasma waves. The book is organized into two major parts, examining both linear and nonlinear plasma waves in the eight chapters it encompasses. After briefly discussing the properties and applications of plasma wave, the book goes on examining the wave types in a cold, magnetized plasma and the general forms of the dispersion relation that characterize the waves and label the various types of solutions. Chapters 3 and 4 analyze the acoustic phenomena through the fluid model of plasma and the kinetic effects. Th

  10. Branching ratios, CP asymmetries and polarizations of B → ψ(2S)V decays

    Energy Technology Data Exchange (ETDEWEB)

    Rui, Zhou [North China University of Science and Technology, College of Sciences, Tangshan (China); Li, Ya; Xiao, Zhen-Jun [Nanjing Normal University, Department of Physics and Institute of Theoretical Physics, Nanjing, Jiangsu (China)

    2017-09-15

    We analyze the non-leptonic decays B/B{sub s} → ψ(2S)V with V = (ρ, ω, K*, φ) by employing the perturbative QCD (pQCD) factorization approach. Here the branching ratios, the CP asymmetries and the complete set of polarization observables are investigated systematically. Besides the traditional contributions from the factorizable and non-factorizable diagrams at the leading order, the next-to-leading order (NLO) vertex corrections could also provide considerable contributions. The pQCD predictions for the branching ratios of the B{sub (s)} → ψ(2S)K*, ψ(2S)φ decays are consistent with the measured values within errors. As for B → ψ(2S)ρ, ψ(2S)ω decays, the branching ratios can reach the order of 10{sup -5} and could be measured in the LHCb and Belle-II experiments. The numerical results show that the direct CP asymmetries of the considered decays are very small. Thus the observation of any large direct CP asymmetry for these decays will be a signal for new physics. The mixing-induced CP asymmetries in the neutral modes are very close to sin 2β{sub (s)}, which suggests that these channels can give a cross-check on the measurement of the Cabbibo-Kobayashi-Maskawa (CKM) angle β and β{sub s}. We find that the longitudinal polarization fractions f{sub 0} are suppressed to ∝ 50% due to the large non-factorizable contributions. The magnitudes and phases of the two transverse amplitudes A {sub parallel} and A {sub perpendicular} {sub to} are roughly equal, which is an indication for the approximate light-quark helicity conservation in these decays. The overall polarization observables of B → ψ(2S)K{sup *0} and B{sub s} → ψ(2S)φ channels are also in good agreement with the experimental measurements as reported by LHCb and BaBar. Other results can also be tested by the LHCb and Belle-II experiments. (orig.)

  11. Scattering of quasi seismic waves between self-reinforced and triclinic media

    Science.gov (United States)

    Kumari, Pato

    2017-10-01

    Present work explores scattering of two-dimensional plane quasi longitudinal and quasi shear vertical waves through a triclinic medium laid over by a self-reinforced half space. The analytical expressions for velocity of all the scattered waves are derived in compact form. Reflection and transmission angles along with scattered velocities are computed numerically for particular model and the variations in same have been studied against propagation angle of incident qP/qSV wave. The variation of reflection/transmission angles and velocity versus incident angle for unconstrained and constrained conditions are plotted using MATLAB plots. Critical angle for grazing phenomenon is found for both incident qP and qSV waves. The present work has its utility in reflection problems where highly anisotropic source region encounters reinforced layered obstruction.

  12. High-speed dynamic-clamp interface

    Science.gov (United States)

    Yang, Yang; Adowski, Timothy; Ramamurthy, Bina; Neef, Andreas

    2015-01-01

    The dynamic-clamp technique is highly useful for mimicking synaptic or voltage-gated conductances. However, its use remains rare in part because there are few systems, and they can be expensive and difficult for less-experienced programmers to implement. Furthermore, some conductances (such as sodium channels) can be quite rapid or may have complex voltage sensitivity, so high speeds are necessary. To address these issues, we have developed a new interface that uses a common personal computer platform with National Instruments data acquisition and WaveMetrics IGOR to provide a simple user interface. This dynamic clamp implements leak and linear synaptic conductances as well as a voltage-dependent synaptic conductance and kinetic channel conductances based on Hodgkin-Huxley or Markov models. The speed of the system can be assayed using a testing mode, and currently speeds of >100 kHz (10 μs per cycle) are achievable with short latency and little jitter. PMID:25632075

  13. Wave Star

    DEFF Research Database (Denmark)

    Kramer, Morten; Brorsen, Michael; Frigaard, Peter

    Denne rapport beskriver numeriske beregninger af forskellige flydergeometrier for bølgeenergianlæget Wave Star.......Denne rapport beskriver numeriske beregninger af forskellige flydergeometrier for bølgeenergianlæget Wave Star....

  14. Heat Waves

    Science.gov (United States)

    Heat Waves Dangers we face during periods of very high temperatures include: Heat cramps: These are muscular pains and ... having trouble with the heat. If a heat wave is predicted or happening… - Slow down. Avoid strenuous ...

  15. Wave Dragon

    DEFF Research Database (Denmark)

    Kofoed, Jens Peter; Frigaard, Peter; Sørensen, H. C.

    1998-01-01

    This paper concerns with the development of the wave energy converter (WEC) Wave Dragon. This WEC is based on the overtopping principle. An overview of the performed research done concerning the Wave Dragon over the past years is given, and the results of one of the more comprehensive studies......, concerning a hydraulic evaluation and optimisation of the geometry of the Wave Dragon, is presented. Furthermore, the plans for the future development projects are sketched....

  16. Gravitational Waves

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Jonah Maxwell [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-10-18

    This report has slides on Gravitational Waves; Pound and Rebka: A Shocking Fact; Light is a Ruler; Gravity is the Curvature of Spacetime; Gravitational Waves Made Simple; How a Gravitational Wave Affects Stuff Here; LIGO; This Detection: Neutron Stars; What the Gravitational Wave Looks Like; The Sound of Merging Neutron Stars; Neutron Star Mergers: More than GWs; The Radioactive Cloud; The Kilonova; and finally Summary, Multimessenger Astronomy.

  17. Development of an Active-Learning Program About Mechanical Wave

    Science.gov (United States)

    Kogetsu, Hisashi; Taniguchi, Kazunari

    In our preliminary survey of students' conceptual understanding of a mechanical wave with Wave Diagnostic Test, we found that Japanese students have "particle pulses mental model" such that the wave speed changes depending on frequency and/or amplitude of the wave source. We have developed an active-learning program about the mechanical wave based on instructional strategies used by Physics Education Group to improve students' mental model.

  18. Electromagnetic Waves

    OpenAIRE

    Blok, H.; van den Berg, P.M.

    2011-01-01

    This book is dedicated to various aspects of electromagnetic wave theory and its applications in science and technology. The covered topics include the fundamental physics of electromagnetic waves, theory of electromagnetic wave propagation and scattering, methods of computational analysis, material characterization, electromagnetic properties of plasma, analysis and applications of periodic structures and waveguide components, etc.

  19. Wave Dragon

    DEFF Research Database (Denmark)

    Tedd, James; Kofoed, Jens Peter; Knapp, W.

    2006-01-01

    Wave Dragon is a floating wave energy converter working by extracting energy principally by means of overtopping of waves into a reservoir. A 1:4.5 scale prototype has been sea tested for 20 months. This paper presents results from testing, experiences gained and developments made during...

  20. Wave phenomena

    CERN Document Server

    Towne, Dudley H

    1988-01-01

    This excellent undergraduate-level text emphasizes optics and acoustics, covering inductive derivation of the equation for transverse waves on a string, acoustic plane waves, boundary-value problems, polarization, three-dimensional waves and more. With numerous problems (solutions for about half). ""The material is superbly chosen and brilliantly written"" - Physics Today. Problems. Appendices.

  1. Traffic speed management

    Directory of Open Access Journals (Sweden)

    Subotić Jovana Lj.

    2014-01-01

    Full Text Available Speed, and vehicles themselves, affect the level of service and road safety, quality of life, noise from traffic, the environment, health, air pollution, emission of carbon dioxide, global warming, the economy and consumption of non-renewable energy such as oil. Therefore, the speed management of the traffic of multiple significance and that should be primarily to provide effective and economical conditions of the modern and preventive protection of human life as the greatest treasure and then the material resources. The way to accomplish this is by using various (different measures such as: appropriate planning and projecting roads and streets, speed control, the legislation, enforcement, campaigns, education, advanced technologies (ITS.

  2. Nonlinear ship waves and computational fluid dynamics

    National Research Council Canada - National Science Library

    MIYATA, Hideaki; ORIHARA, Hideo; SATO, Yohei

    2014-01-01

    .... Finding of the occurrence of nonlinear waves (named Free-Surface Shock Waves) in the vicinity of a ship advancing at constant speed provided the start-line for the progress of innovative technologies in the ship hull-form design...

  3. Magnetic Fields inside Extremely Fast Shock Waves

    NARCIS (Netherlands)

    Wiersma, J.

    2007-01-01

    The aim of my research on magnetic fields in extremely fast shock waves has been to predict the properties of shock waves that move almost with the speed of light. These shocks are created in the tenuous interstellar medium by catastrophic events such as the explosion of stars many times

  4. Subcellular localization of SV2 and other secretory vesicle components in PC12 cells by an efficient method of preembedding EM immunocytochemistry for cell cultures

    DEFF Research Database (Denmark)

    Tanner, V A; Ploug, Thorkil; Tao-Cheng, J H

    1996-01-01

    substantially improved the efficiency of the preembedding EM ICC procedures for cell cultures. The advantages and related caveats of this method are discussed. SV2 was distinctly localized on dusters of synaptic vesicles and large dense-cored vesicles (LDCV). The distribution of SV2 on these two types...... membranes. Furthermore, whereas SV2 is localized on the membranes of the LDCVs, chromogranin A, an acidic protein in secretory granules, is clearly in the core of the LDCVs. This is the first demonstration of these two antigens in such dose (approximately 20 nm) yet distinct compartments within a single...

  5. Wind_Speeds_Master

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set included wind speeds for each subregion in the study (Georges Bank, Gulf of Maine, Southern New England, Middle Atlantic Bight) . The data came from...

  6. High speed heterostructure devices

    CERN Document Server

    Beer, Albert C; Willardson, R K; Kiehl, Richard A; Sollner, T C L Gerhard

    1994-01-01

    Volume 41 includes an in-depth review of the most important, high-speed switches made with heterojunction technology. This volume is aimed at the graduate student or working researcher who needs a broad overview andan introduction to current literature. Key Features * The first complete review of InP-based HFETs and complementary HFETs, which promise very low power and high speed * Offers a complete, three-chapter review of resonant tunneling * Provides an emphasis on circuits as well as devices.

  7. High Speed Ice Friction

    Science.gov (United States)

    Seymour-Pierce, Alexandra; Sammonds, Peter; Lishman, Ben

    2014-05-01

    Many different tribological experiments have been run to determine the frictional behaviour of ice at high speeds, ostensibly with the intention of applying results to everyday fields such as winter tyres and sports. However, experiments have only been conducted up to linear speeds of several metres a second, with few additional subject specific studies reaching speeds comparable to these applications. Experiments were conducted in the cold rooms of the Rock and Ice Physics Laboratory, UCL, on a custom built rotational tribometer based on previous literature designs. Preliminary results from experiments run at 2m/s for ice temperatures of 271 and 263K indicate that colder ice has a higher coefficient of friction, in accordance with the literature. These results will be presented, along with data from further experiments conducted at temperatures between 259-273K (in order to cover a wide range of the temperature dependent behaviour of ice) and speeds of 2-15m/s to produce a temperature-velocity-friction map for ice. The effect of temperature, speed and slider geometry on the deformation of ice will also be investigated. These speeds are approaching those exhibited by sports such as the luge (where athletes slide downhill on an icy track), placing the tribological work in context.

  8. S wave propagation in acoustic anisotropic media

    Science.gov (United States)

    Stovas, Alexey

    2017-04-01

    The acoustic anisotropic medium can be defined in two ways. The first one is known as a pseudo-acoustic approximation (Alkhalifah, 1998) that is based on the fact that in TI media, P wave propagation is weakly dependent on parameter known as "vertical S-wave velocity" (Thomsen, 1986). The standard way to define the pseudo-acoustic approximation is to set this parameter to zero. However, as it was shown later (Grechka et al., 2004), there is "S wave artifact" in such a medium. Another way is to define the stack of horizontal solid-fluid layers and perform an upscaling based on the Backus (1962) averaging. The stiffness coefficient that responds to "vertical S wave velocity" turns to zero if any of layers has zero vertical S wave velocity. In this abstract, I analyze the S wave propagation is acoustic anisotropic medium and define important kinematic properties such as the group velocity surface and Dix-type equations. The kinematic properties can easily be defined from the slowness surface. In elastic transversely isotropic medium, the equations for P and SV wave slowness surfaces are coupled. Setting "vertical S wave velocity" to zero, results in decoupling of equations. I show that the S wave group velocity surface is given by quasi-astroidal form with the reference astroid defined by vertical and horizontal projections of group velocity. I show that there are cusps attached to both vertical and horizontal symmetry axes. The new S wave parameters include vertical, horizontal and normal moveout velocities. With the help of new parameterization, suitable for S wave, I also derived the Dix-type of equations to define the effective kinematical properties of S waves in multi-layered acoustic anisotropic medium. I have shown that effective media defined from P and S waves have different parameters. I also show that there are certain symmetries between P and S waves parameters and equations. The proposed method can be used for analysis of S waves in acoustic anisotropic

  9. Speed-calming measures and their Effect on driving speed

    DEFF Research Database (Denmark)

    Agerholm, Niels; Knudsen, Daniel; Variyeswaran, Kajan

    2017-01-01

    Highlights •Speed humps and chicanes are widespread speed-calming measures. •Humps and chicanes have virtually the same reducing effect on mean speed. •Chicanes reduce speed variation less than humps and might therefore be a less safe measure.......Highlights •Speed humps and chicanes are widespread speed-calming measures. •Humps and chicanes have virtually the same reducing effect on mean speed. •Chicanes reduce speed variation less than humps and might therefore be a less safe measure....

  10. The lifecycle of axisymmetric internal solitary waves

    Directory of Open Access Journals (Sweden)

    J. M. McMillan

    2010-09-01

    Full Text Available The generation and evolution of solitary waves by intrusive gravity currents in an approximate two-layer fluid with equal upper- and lower-layer depths is examined in a cylindrical geometry by way of theory and numerical simulations. The study is limited to vertically symmetric cases in which the density of the intruding fluid is equal to the average density of the ambient. We show that even though the head height of the intrusion decreases, it propagates at a constant speed well beyond 3 lock radii. This is because the strong stratification at the interface supports the formation of a mode-2 solitary wave that surrounds the intrusion head and carries it outwards at a constant speed. The wave and intrusion propagate faster than a linear long wave; therefore, there is strong supporting evidence that the wave is indeed nonlinear. Rectilinear Korteweg-de Vries theory is extended to allow the wave amplitude to decay as r-p with p=½ and the theory is compared to the observed waves to demonstrate that the width of the wave scales with its amplitude. After propagating beyond 7 lock radii the intrusion runs out of fluid. Thereafter, the wave continues to spread radially at a constant speed, however, the amplitude decreases sufficiently so that linear dispersion dominates and the amplitude decays with distance as r-1.

  11. Cyber Security Indications and Warning System (SV): CRADA 1573.94 Project Accomplishments Summary

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Tan Chang (PI, Sandia); Robinson, David G. (Technical PI)

    2011-09-08

    As the national focus on cyber security increases, there is an evolving need for a capability to provide for high-speed sensing of events, correlation of events, and decision-making based on the adverse events seen across multiple independent large-scale network environments. The purpose of this Shared Vision project, Cyber Security Indications and Warning System, was to combine both Sandia's and LMC's expertise to discover new solutions to the challenge of protecting our nation's infrastructure assets. The objectives and scope of the proposal was limited to algorithm and High Performance Computing (HPC) model assessment in the unclassified environment within funding and schedule constraints. The interest is the identification, scalability assessment, and applicability of current utilized cyber security algorithms as applied in an HPC environment.

  12. Everyone Deserves a Speeding Ticket.

    Science.gov (United States)

    Burris, Harold

    1993-01-01

    Presents a first day physics activity having students determine the fine for a speeding ticket if the speeds considered include the earth's rotation and revolution speed, and the movement through the galaxy. (MDH)

  13. MHD wave transmission in the Sun's atmosphere

    Science.gov (United States)

    Stangalini, M.; Del Moro, D.; Berrilli, F.; Jefferies, S. M.

    2011-10-01

    Magnetohydrodynamics (MHD) wave propagation inside the Sun's atmosphere is closely related to the magnetic field topology. For example, magnetic fields are able to lower the cutoff frequency for acoustic waves, thus allowing the propagation of waves that would otherwise be trapped below the photosphere into the upper atmosphere. In addition, MHD waves can be either transmitted or converted into other forms of waves at altitudes where the sound speed equals the Alfvén speed. We take advantage of the large field-of-view provided by the IBIS experiment to study the wave propagation at two heights in the solar atmosphere, which is probed using the photospheric Fe 617.3 nm spectral line and the chromospheric Ca 854.2 nm spectral line, and its relationship to the local magnetic field. Among other things, we find substantial leakage of waves with five-minute periods in the chromosphere at the edges of a pore and in the diffuse magnetic field surrounding it. By using spectropolarimetric inversions of Hinode SOT/SP data, we also find a relationship between the photospheric power spectrum and the magnetic field inclination angle. In particular, we identify well-defined transmission peaks around 25° for five-minute waves and around 15° for three-minute waves. We propose a very simple model based on wave transmission theory to explain this behavior. Finally, our analysis of both the power spectra and chromospheric amplification spectra suggests the presence of longitudinal acoustic waves along the magnetic field lines.

  14. On the unstable mode merging of gravity-inertial waves with Rossby waves

    Directory of Open Access Journals (Sweden)

    J. F. McKenzie

    2011-08-01

    Full Text Available We recapitulate the results of the combined theory of gravity-inertial-Rossby waves in a rotating, stratified atmosphere. The system is shown to exhibit a "local" (JWKB instability whenever the phase speed of the low-frequency-long wavelength westward propagating Rossby wave exceeds the phase speed ("Kelvin" speed of the high frequency-short wavelength gravity-inertial wave. This condition ensures that mode merging, leading to instability, takes place in some intermediate band of frequencies and wave numbers. The contention that such an instability is "spurious" is not convincing. The energy source of the instability resides in the background enthalpy which can be released by the action of the gravitational buoyancy force, through the combined wave modes.

  15. Effects of Enrichment and Litter Parity on Reproductive Performance and Behavior in BALB/c and 129/Sv Mice

    Science.gov (United States)

    Whitaker, Julia W; Moy, Sheryl S; Pritchett-Corning, Kathleen R; Fletcher, Craig A

    2016-01-01

    We examined the effect of adding species-appropriate environmental enrichment items to breeding cages of BALB/cAnNCrl and 129S2/SvPasCrl mice. The 3 enrichment conditions were: 1) cotton nesting material; 2) nesting material plus a paper shelter and rolled paper bedding; and 3) an igloo dome with an exercise wheel in addition to the shelter-group enrichments. We measured litter size, litter survival to weaning age, average pup weight at 21 d, and the interlitter interval to evaluate reproductive performance. A random subset of the first- or second-litter offspring from each enrichment condition and strain was assessed in multiple behavioral tests. Enrichment significantly affected anxiety-like behavior and sociability, with the direction of change dependent on strain and sex. Litter parity had greater effects on some reproductive parameters than did the enrichment condition, and this effect was not solely due to a difference between the first compared with subsequent litters. The significant effects of litter parity on the number of pups born and weaned, female pup weight, and interlitter interval were dependent on the enrichment condition in BALB/c but not 129/Sv mice. Offspring from the first or second litter were included in a generational component to investigate whether enrichment effects on reproduction persist in adult offspring after transfer to a different facility for breeding. Natal cage enrichment had no effect on any reproductive parameter in the transferred mice. Overall, additional enrichment beyond nesting material had a beneficial effect on the interlitter interval in BALB/c mice and on the number of pups weaned in 129/Sv mice. PMID:27423144

  16. Observational Constraints on Terpene Oxidation with and without Anthropogenic Influence in the Amazon using Speciated Measurements from SV-TAG

    Science.gov (United States)

    Yee, L.; Isaacman, G. A.; Kreisberg, N. M.; Liu, Y.; McKinney, K. A.; de Sá, S. S.; Martin, S. T.; Alexander, M. L.; Palm, B. B.; Hu, W.; Campuzano Jost, P.; Day, D. A.; Jimenez, J. L.; Viegas, J.; Springston, S. R.; Wurm, F.; Ferreira De Brito, J.; Artaxo, P.; Manzi, A. O.; Machado, L.; Longo, K.; Oliveira, M. B.; Souza, R. A. F. D.; Hering, S. V.; Goldstein, A. H.

    2014-12-01

    Biogenic volatile organic compounds (BVOCs) from the Amazon forest represent the largest regional source of organic carbon emissions to the atmosphere. These BVOC emissions dominantly consist of volatile and semi-volatile terpenoid compounds that undergo chemical transformations in the atmosphere to form oxygenated condensable gases and secondary organic aerosol (SOA). However, the oxidation pathways of these compounds are still not well understood, and are expected to differ significantly between "pristine" conditions, as is common in Amazonia, and polluted conditions caused by emissions from growing cities. Our focus is to elucidate how anthropogenic emissions influence BVOC chemistry and BSOA formation through speciated measurements of their oxidation products. We have deployed the Semi-Volatile Thermal desorption Aerosol Gas Chromatograph (SV-TAG) at the rural T3 site located west of the urban center of Manaus, Brazil as part of the Green Ocean Amazon (GoAmazon) 2014 field campaign to measure hourly concentrations of semi-volatile BVOCs and their oxidation products during the wet and dry seasons. Primary BVOC concentrations measured by the SV-TAG include sesquiterpenes and diterpenes, which have rarely been speciated with high time-resolution. We observe sesquiterpenes to be anti-correlated with ozone, indicative of sesquiterpene oxidation playing a major role in the regional oxidant budget. The role of sesquiterpenes in atmospheric SOA formation are of interest due to their high aerosol yields and high reactivity with ozone, relative to more commonly measured BVOCs (e.g. monoterpenes). We explore relative concentrations of sesquiterpenes and monoterpenes and their roles as precursors to SOA formation by combining SV-TAG measurements with those from an additional suite of VOC and particle measurements deployed in the Amazon. We also report the first ever hourly observations of the gas-particle partitioning of speciated terpene oxidation products in the Amazon

  17. Comparative Transcriptome Profiling of an SV40-Transformed Human Fibroblast (MRC5CVI) and Its Untransformed Counterpart (MRC-5) in Response to UVB Irradiation

    OpenAIRE

    Cheng-Wei Chang; Chaang-Ray Chen; Chao-Ying Huang; Wun-Yi Shu; Chi-Shiun Chiang; Ji-Hong Hong; Hsu, Ian C.

    2013-01-01

    Simian virus 40 (SV40) transforms cells through the suppression of tumor-suppressive responses by large T and small t antigens; studies on the effects of these two oncoproteins have greatly improved our knowledge of tumorigenesis. Large T antigen promotes cellular transformation by binding and inactivating p53 and pRb tumor suppressor proteins. Previous studies have shown that not all of the tumor-suppressive responses were inactivated in SV40-transformed cells; however, the underlying cause ...

  18. Mapping speed for an array of corrugated horns.

    Science.gov (United States)

    Padin, Stephen

    2010-01-20

    I address the choice of horn diameter for millimeter-wave array receivers with corrugated horns. For maximum point-source mapping speed, in both total power and polarization with typical receiver noise contributions and a close-packed horn array that fills the field of view, the optimum horn diameter is 1.6-1.7Flambda, where F is the focal ratio. A +/-25% change in horn diameter gives effect on the mapping speed and optimum horn diameter.

  19. On the structure of artificially generated water wave trains

    Science.gov (United States)

    Papadimitrakis, Yiannis A.

    1986-01-01

    The structure of an artificially generated sinusoidal water wave train of fixed frequency under the influence of wind is analyzed. Artificially generated waves of 1 Hz are studied at seven wind speeds in the range of 140-400 cm/s. It is observed that the water wave train deformed by wind consists of two components at both the fundamental mode and the harmonics. The amplitude and phase of the wave components are derived, and the dispersion relation and component phase speeds are examined. The data reveal that the amplitude of the forced and free-traveling second harmonics correlate with previous theories, and that the deviation of the measured phase speed from the linear theory is caused by the nonlinearity of the primary wave, the interaction between short gravity waves and the primary wave, and the advection effects of wind drift.

  20. Extremely high-speed imaging based on tubeless technology

    Science.gov (United States)

    Li, Jingzhen

    2008-11-01

    This contribution focuses on the tubeless imaging, the extreme-high speed imaging. A detail discussion is presented on how and why to make them, which would be the most important in the high speed imaging field in the future. Tubeless extreme-high speed imaging can not only be used to observe the transient processes like collision, detonating, and high voltage discharge, but also to research the processes like disintegration and transfer of phonon and exacton in solid, photosynthesis primitive reaction, and electron dynamics inside atom shell. Its imaging frequency is about 107~1015fps. For this kind of imaging, the mechanism of how forming both high speed and framing would better make fine use of the light speed, the light parallelism, the parameters of light wave such as its amplitude, phase, polarization and wave length, and even quantum characteristics of photons. In the cascade connection system of electromagnetic wave and particle wave, it is able to simultaneously realize high level both the temporal resolution and the spatial resolution, and it would be possible to break through the limit of the Heisenberg uncertainty correlation of the optical frequency band.

  1. Variable Speed Rotor System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Variable speed rotors will give helicopters several advantages: higher top speed, greater fuel efficiency, momentary emergency over-power, resonance detuning...

  2. Gravitation Waves

    CERN Multimedia

    CERN. Geneva

    2005-01-01

    We will present a brief introduction to the physics of gravitational waves and their properties. We will review potential astrophysical sources of gravitational waves, and the physics and astrophysics that can be learned from their study. We will survey the techniques and technologies for detecting gravitational waves for the first time, including bar detectors and broadband interferometers, and give a brief status report on the international search effort, with special emphasis on the LIGO detectors and search results.

  3. PERSONALITY AND SPEEDING

    Directory of Open Access Journals (Sweden)

    Richard TAY

    2003-01-01

    Full Text Available While there has been extensive research on the effect of sensation seeking on risky driving, relatively little research has been conducted on Type-A personality. The motivations for speeding are likely to be different for each group and these differences have important implications for the design, implementation and expected efficacy of road safety countermeasures. This paper examines the influence of sensation seeking and Type-A behavior pattern on speeding behaviour. A sample of 139 staff and students in an Australian university were surveyed in July 2001 to gather information on their gender, age, personality and self-reported speeding behaviour. The data were analysed using correlations and analysis of variance procedures. Finally, some implications for road safety are discussed.

  4. Janus Waves

    OpenAIRE

    Papazoglou, Dimitris G.; Fedorov, Vladimir Yu.; Tzortzakis, Stelios

    2016-01-01

    We show the existence of a family of waves that share a common interesting property affecting the way they propagate and focus. These waves are a superposition of twin waves, which are conjugate to each other under inversion of the propagation direction. In analogy to holography, these twin "real" and "virtual" waves are related respectively to the converging and the diverging part of the beam and can be clearly visualized in real space at two distinct foci under the action of a focusing lens...

  5. Analytical design of a parasitic-loading digital speed controller for a 400-hertz turbine driven alternator

    Science.gov (United States)

    Ingle, B. D.; Ryan, J. P.

    1972-01-01

    A design for a solid-state parasitic speed controller using digital logic was analyzed. Parasitic speed controllers are used in space power electrical generating systems to control the speed of turbine-driven alternators within specified limits. The analysis included the performance characteristics of the speed controller and the generation of timing functions. The speed controller using digital logic applies step loads to the alternator. The step loads conduct for a full half wave starting at either zero or 180 electrical degrees.

  6. Assimilation of Wave Imaging Radar Observations for Real-time Wave-by-Wave Forecasting

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, Alexandra [Oregon State Univ., Corvallis, OR (United States); Haller, Merrick [Oregon State Univ., Corvallis, OR (United States). School of Civil & Construction Engineering; Walker, David [SRI International, Menlo Park, CA (United States); Lynett, Pat [Univ. of Southern California, Los Angeles, CA (United States)

    2017-08-29

    This project addressed Topic 3: “Wave Measurement Instrumentation for Feed Forward Controls” under the FOA number DE-FOA-0000971. The overall goal of the program was to develop a phase-resolving wave forecasting technique for application to the active control of Wave Energy Conversion (WEC) devices. We have developed an approach that couples a wave imaging marine radar with a phase-resolving linear wave model for real-time wave field reconstruction and forward propagation of the wave field in space and time. The scope of the project was to develop and assess the performance of this novel forecasting system. Specific project goals were as follows: Develop and verify a fast, GPU-based (Graphical Processing Unit) wave propagation model suitable for phase-resolved computation of nearshore wave transformation over variable bathymetry; Compare the accuracy and speed of performance of the wave model against a deep water model in their ability to predict wave field transformation in the intermediate water depths (50 to 70 m) typical of planned WEC sites; Develop and implement a variational assimilation algorithm that can ingest wave imaging radar observations and estimate the time-varying wave conditions offshore of the domain of interest such that the observed wave field is best reconstructed throughout the domain and then use this to produce model forecasts for a given WEC location; Collect wave-resolving marine radar data, along with relevant in situ wave data, at a suitable wave energy test site, apply the algorithm to the field data, assess performance, and identify any necessary improvements; and Develop a production cost estimate that addresses the affordability of the wave forecasting technology and include in the Final Report. The developed forecasting algorithm (“Wavecast”) was evaluated for both speed and accuracy against a substantial synthetic dataset. Early in the project, performance tests definitively demonstrated that the system was capable of

  7. Millimeter Wave Communications

    Science.gov (United States)

    1984-06-01

    64 64:7 34OF9 043 64 ?~ 4’ ’ J "IN0󈨀 ŗ 34 69044137 Saw a.? 64 3 3 6 N @6’ 4’ ) IF6 1.41 W i V ature will give values to be expected (Reference 9: 322...Octooer 1978, the Atmospheric Sciences Laboratories c’nducted a malor test called DIRT-I, to obtain direct sensor information about the properties of dust...wave frequencies (2.15) D where G v Antenna gain a Wavelength in meters c = Speed of light - 3.0 x 10meterslsecond f a Frequency in Hertz A

  8. Olipski fragment gotičkoga srebrnog ophodnog križa s prikazom Sv. Stošije

    Directory of Open Access Journals (Sweden)

    Marijana Kovačević

    2013-12-01

    Full Text Available U župnom uredu u Olibu prije nekoliko je godina pronađen zanimljiv srebrni fragment s prikazom svetice. Slijedom usporedbe sa srodnim liturgijskim predmetima utvrđuje se da je riječ o fragmentu ophodnoga križa s prikazom svetice zaštitnice olipske župe, sv. Stošije, koji je nekada bio pričvršćen u središtu njegova reversa, te se određuje njegova datacija u konac 14. st. Ikonografska je identifikacija prikazanoga lika, osim logikom mjesta nalaza, učvršćena i ikonografskom analizom prikaza sv. Stošije u romaničkoj i gotičkoj umjetnosti na području Zadra nastalih tijekom toga višestoljetnoga razdoblja, napose u zlatarstvu, te je na taj način utvrđen i svojevrstan evolutivni pomak u prikazivanju svetice koja je ujedno i zaštitnica Zadarske nadbiskupije.

  9. Dissociation of DNA damage and mitochondrial injury caused by hydrogen peroxide in SV-40 transformed lung epithelial cells

    Directory of Open Access Journals (Sweden)

    Adcock Ian M

    2002-11-01

    Full Text Available Abstract Background Since lung epithelial cells are constantly being exposed to reactive oxygen intermediates (ROIs, the alveolar surface is a major site of oxidative stress, and each cell type may respond differently to oxidative stress. We compared the extent of oxidative DNA damage with that of mitochondrial injury in lung epithelial cells at the single cell level. Result DNA damage and mitochondrial injury were measured after oxidative stress in the SV-40 transformed lung epithelial cell line challenged with hydrogen peroxide (H2O2. Single cell analysis of DNA damage was determined by assessing the number of 8-oxo-2-deoxyguanosine (8-oxo-dG positive cells, a marker of DNA modification, and the length of a comet tail. Mitochondrial membrane potential, ΔΨm, was determined using JC-1. A 1 h pulse of H2O2 induced small amounts of apoptosis (3%. 8-oxo-dG-positive cells and the length of the comet tail increased within 1 h of exposure to H2O2. The number of cells with reduced ΔΨm increased after the addition of H2O2 in a concentration-dependent manner. In spite of a continual loss of ΔΨm, DNA fragmentation was reduced 2 h after exposure to H2O2. Conclusion The data suggest that SV-40 transformed lung epithelial cells are resistant to oxidative stress, showing that DNA damage can be dissociated from mitochondrial injury.

  10. The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA.

    Science.gov (United States)

    Gai, Dahai; Wang, Damian; Li, Shu-Xing; Chen, Xiaojiang S

    2016-12-06

    DNA replication is a fundamental biological process. The initial step in eukaryotic DNA replication is the assembly of the pre-initiation complex, including the formation of two head-to-head hexameric helicases around the replication origin. How these hexameric helicases interact with their origin dsDNA remains unknown. Here, we report the co-crystal structure of the SV40 Large-T Antigen (LT) hexameric helicase bound to its origin dsDNA. The structure shows that the six subunits form a near-planar ring that interacts with the origin, so that each subunit makes unique contacts with the DNA. The origin dsDNA inside the narrower AAA+ domain channel shows partial melting due to the compression of the two phosphate backbones, forcing Watson-Crick base-pairs within the duplex to flip outward. This structure provides the first snapshot of a hexameric helicase binding to origin dsDNA, and suggests a possible mechanism of origin melting by LT during SV40 replication in eukaryotic cells.

  11. Dedicated sub 0.1 mSv 3DCT using MBIR in children with suspected craniosynostosis: quality assessment

    Energy Technology Data Exchange (ETDEWEB)

    Ernst, Caroline W.; Hulstaert, Tine L.; Belsack, Dries; Buls, Nico; Gompel, Gert van; Nieboer, Koenraad H.; Verhelle, Filip; Maeseneer, Michel de; Mey, Johan de [Universitair Ziekenhuis Brussel, Department of Radiology, Brussels (Belgium); Buyl, Ronald [Vrije Universiteit Brussel, Department of Biomedical Statistics and Informatics, Brussels (Belgium)

    2016-03-15

    To retrospectively compare image quality of a lowered dose CT protocol to a standard CT protocol in children with suspicion of craniosynostosis. Forty-eight patients (age 0- 35 months), who presented with a cranial deformity underwent cranial 3D CT to assess sutural patency: between 2009 - 2010, 24 patients were imaged with a standard protocol (CTDIvol 32.18 mGy), from 2011-2012, 24 underwent a low dose protocol (0.94 mGy) combined with iterative reconstruction. Image quality was evaluated by both expert reading and objective analysis. Differences were assessed by independent t-test and Mann-Whitney U test, interreader agreement by Cohen's Kappa test. Effective dose of the low dose protocol was 0.08 mSv, corresponding to a reduction of 97 %. Image quality was similar in both groups in terms of overall diagnostic acceptability, objective noise measurements, subjective cranial bone edge sharpness and presence of artefacts. For objective sharpness of cranial bone-brain interface and subjective perception of noise, the images of the low dose protocol were superior. For all evaluated structures, interreader agreement was moderate to almost perfect. In the diagnosis of craniosynostosis in children with cranial deformities, a dedicated sub 0.1 mSv cranial 3DCT protocol can be used without loss in image quality. (orig.)

  12. Study on application of single-crystal ice `Kurobe ice column` to high-speed skating rinks. Demonstration test result at Olympic memorial arena `M wave` in Nagano city; Tankesshohyo `Kurobe no hyojun` no kosoku skate link eno tekiyosei kenkyu. Naganoshi olympic kinen arina `Emu Wave` deno jissho shiken kekka

    Energy Technology Data Exchange (ETDEWEB)

    Iwasaki, M. [Kansai Electric Power Co. Inc., Osaka (Japan)

    1999-06-10

    For high-speed low-friction skating rinks, research was made on sticking artificial ice columns (ice bamboo shoot). The ice columns were fabricated with the ice column production equipment equipped with 4-line water droplet dropping devices which were installed at intervals of 0.3m on both sides of a pathway of 200m long, 2.6m wide and 1.8m high in the lateral adit of Kurobegawa No.4 hydroelectric power station. The grown ice columns were processed for high-speed skating rinks through cutting, confirmation of single crystal and crystal orientation, slicing for every 7mm thickness and packaging. The ice columns were spread all over the rink while sliding them to prevent mixing of bubbles after spraying distilled water of nearly 25 degreesC onto base ices. In addition, hot water of nearly 40 degreesC was sprayed to produce the final ice rink of 30mm thick by nearly 5mm a day. The dynamic friction coefficient of the ice column rink reduced to 0.0038 by nearly 16% as compared with 0.0045 of conventional rinks. (NEDO)

  13. Large Scale Model Test Investigation on Wave Run-Up in Irregular Waves at Slender Piles

    DEFF Research Database (Denmark)

    Ramirez, Jorge Robert Rodriguez; Frigaard, Peter; Andersen, Thomas Lykke

    2013-01-01

    from high speed video recordings. Based on the measured run-up heights different types of prediction formulae for run-up in irregular waves were evaluated. In conclusion scale effects on run-up levels seems small except for differences in spray. However, run-up of individual waves is difficult...

  14. Interfering Waves of Adaptation Promote Spatial Mixing

    DEFF Research Database (Denmark)

    Martens, Erik Andreas; Hallatschek, Oskar

    2011-01-01

    , due to the slow wave-like spread of beneficial mutations through space. We find that the adaptation speed of asexuals saturates when the linear habitat size exceeds a characteristic interference length, which becomes shorter with smaller migration and larger mutation rate. The limiting speed...... is proportional to $(1/2) and $(1/3) in linear and planar habitats, respectively, where the mutational supply $ is the product of mutation rate and local population density. This scaling and the existence of a speed limit should be amenable to experimental tests as they fall far below predicted adaptation speeds...

  15. Tropical cyclogenesis in a tropical wave critical layer: easterly waves

    Directory of Open Access Journals (Sweden)

    T. J. Dunkerton

    2009-08-01

    Full Text Available The development of tropical depressions within tropical waves over the Atlantic and eastern Pacific is usually preceded by a "surface low along the wave" as if to suggest a hybrid wave-vortex structure in which flow streamlines not only undulate with the waves, but form a closed circulation in the lower troposphere surrounding the low. This structure, equatorward of the easterly jet axis, is identified herein as the familiar critical layer of waves in shear flow, a flow configuration which arguably provides the simplest conceptual framework for tropical cyclogenesis resulting from tropical waves, their interaction with the mean flow, and with diabatic processes associated with deep moist convection. The recirculating Kelvin cat's eye within the critical layer represents a sweet spot for tropical cyclogenesis in which a proto-vortex may form and grow within its parent wave. A common location for storm development is given by the intersection of the wave's critical latitude and trough axis at the center of the cat's eye, with analyzed vorticity centroid nearby. The wave and vortex live together for a time, and initially propagate at approximately the same speed. In most cases this coupled propagation continues for a few days after a tropical depression is identified. For easterly waves, as the name suggests, the propagation is westward. It is shown that in order to visualize optimally the associated Lagrangian motions, one should view the flow streamlines, or stream function, in a frame of reference translating horizontally with the phase propagation of the parent wave. In this co-moving frame, streamlines are approximately equivalent to particle trajectories. The closed circulation is quasi-stationary, and a dividing streamline separates air within the cat's eye from air outside. The critical layer equatorward of the easterly jet axis is important to tropical cyclogenesis because its cat's eye provides (i a region of

  16. Joint measurement of lensing–galaxy correlations using SPT and DES SV data

    Energy Technology Data Exchange (ETDEWEB)

    Baxter, E.; Clampitt, J.; Giannantonio, T.; Dodelson, S.; Jain, B.; Huterer, D.; Bleem, L.; Crawford, T.; Efstathiou, G.; Fosalba, P.; Kirk, D.; Kwan, J.; Sánchez, C.; Story, K.; Troxel, M. A.; Abbott, T. M. C.; Abdalla, F. B.; Armstrong, R.; Benoit-Lévy, A.; Benson, B.; Bernstein, G. M.; Bernstein, R. A.; Bertin, E.; Brooks, D.; Carlstrom, J.; Rosell, A. Carnero; Carrasco Kind, M.; Carretero, J.; Chown, R.; Crocce, M.; Cunha, C. E.; da Costa, L. N.; Desai, S.; Diehl, H. T.; Dietrich, J. P.; Doel, P.; Evrard, A. E.; Fausti Neto, A.; Flaugher, B.; Frieman, J.; Gruen, D.; Gruendl, R. A.; Gutierrez, G.; de Haan, T.; Holder, G.; Honscheid, K.; Hou, Z.; James, D. J.; Kuehn, K.; Kuropatkin, N.; Lima, M.; March, M.; Marshall, J. L.; Martini, P.; Melchior, P.; Miller, C. J.; Miquel, R.; Mohr, J. J.; Nord, B.; Omori, Y.; Plazas, A. A.; Reichardt, C.; Romer, A. K.; Rykoff, E. S.; Sanchez, E.; Sevilla-Noarbe, I.; Sheldon, E.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Stark, A.; Swanson, M. E. C.; Tarle, G.; Thomas, D.; Walker, A. R.; Wechsler, R. H.

    2016-07-04

    We measure the correlation of galaxy lensing and cosmic microwave background lensing with a set of galaxies expected to trace the matter density field. The measurements are performed using pre-survey Dark Energy Survey (DES) Science Verification optical imaging data and millimetre-wave data from the 2500 sq. deg. South Pole Telescope Sunyaev–Zel'dovich (SPT-SZ) survey. The two lensing–galaxy correlations are jointly fit to extract constraints on cosmological parameters, constraints on the redshift distribution of the lens galaxies, and constraints on the absolute shear calibration of DES galaxy-lensing measurements. We show that an attractive feature of these fits is that they are fairly insensitive to the clustering bias of the galaxies used as matter tracers. The measurement presented in this work confirms that DES and SPT data are consistent with each other and with the currently favoured Λ cold dark matter cosmological model. It also demonstrates that joint lensing–galaxy correlation measurement considered here contains a wealth of information that can be extracted using current and future surveys.

  17. Speeding Up Computers

    OpenAIRE

    Kowalik, Janusz; Arłukowicz, Piotr; Parsons, Erika

    2016-01-01

    There are two distinct approaches to speeding up large parallel computers. The older method is the General Purpose Graphics Processing Units (GPGPU). The newer is the Many Integrated Core (MIC) technology . Here we attempt to focus on the MIC technology and point out differences between the two approaches to accelerating supercomputers. This is a user perspective.

  18. High speed preprocessing system

    Indian Academy of Sciences (India)

    (a) Digitizing and writing the video data in the memory at HR rate, and (b) once the data are ready in the memory, reading the data and generating the LR image. Thus the execution time mainly depends on (i) processor speed, and (ii) the time taken for fetching video information/data. Figure 1. Hardware block diagram. 514.

  19. Variable speed generators

    CERN Document Server

    Boldea, Ion

    2005-01-01

    With the deregulation of electrical energy production and distribution, says Boldea (Polytechnical Institute, Timisoara, Romania) producers are looking for ways to tailor their electricity for different markets. Variable-speed electric generators are serving that purpose, up to the 400 megavolt ampere unit size, in Japan since 1996 and Germany sinc

  20. Rossby Waves

    OpenAIRE

    2005-01-01

    tut quiz Tutorial Quiz Interactive Media Element This interactive tutorial reviews the mechanisms of Rossby waves. Rossby waves in both the northern and southern hemispheres are considered. The interactions involve answering simple fill-in-the-blank questions. Diagrams are used to illustrate some of the concepts reviewed. MR4322 Dynamic Meteorology

  1. Wave Dragon

    DEFF Research Database (Denmark)

    Tedd, James; Kofoed, Jens Peter; Friis-Madsen, Erik

    2008-01-01

    Since March 2003 a prototype of Wave Dragon has been tested in an inland sea in Denmark. This has been a great success with all subsystems tested and improved through working in an offshore environment. The project has proved the Wave Dragon device and has enabled the next stage, a production sized...

  2. Wave Star

    DEFF Research Database (Denmark)

    Kramer, Morten; Brorsen, Michael; Frigaard, Peter

    Nærværende rapport beskriver numeriske beregninger af den hydrodynamiske interaktion mellem 5 flydere i bølgeenergianlægget Wave Star.......Nærværende rapport beskriver numeriske beregninger af den hydrodynamiske interaktion mellem 5 flydere i bølgeenergianlægget Wave Star....

  3. Flexural waves on narrow plates.

    Science.gov (United States)

    Norris, Andrew N

    2003-05-01

    Flexural wave speeds on beams or plates depend upon the bending stiffnesses which differ by the well-known factor (1 - nu2). A quantitative analysis of a plate of finite lateral width displays the plate-to-beam transition, and permits asymptotic analysis that shows the leading order dependence on the width. Orthotropic plates are analyzed using both the Kirchhoff and Kirchhoff-Rayleigh theories, and isotropic plates are considered for Mindlin's theory with and without rotational inertia. A frequency-dependent Young's modulus for beams or strips of finite width is suggested, although the form of the correction to the modulus is not unique and depends on the theory used. The sign of the correction for the Kirchhoff theory is opposite to that for the Mindlin theory. These results indicate that the different plate and beam theories can produce quite distinct behavior. This divergence in predictions is further illustrated by comparison of the speeds for antisymmetric flexural, or torsional, modes on narrow plates. The four classical theories predict limiting wave speeds as the plate width vanishes, but the values are different in each case. The deviations can be understood in terms of torsional waves and how each theory succeeds, or fails, in approximating the effect of torsion. Dispersion equations are also derived, some for the first time, for the flexural edge wave in each of the four "engineering" theories.

  4. Method for rudder roll stabilization control by maintaining ship speed

    Directory of Open Access Journals (Sweden)

    LIU Zhiquan

    2017-01-01

    Full Text Available A ship navigating on the surface of the water may experience greater resistance, adversely affect-ing its speed and leading to energy loss. The added resistance of surface ships in both still water and waves are investigated, and the computation method of total speed loss is presented. An autopilot system is intro-duced to constrain the speed loss, and course keeping and rudder roll stabilization sliding mode control laws are proposed according to a compact control strategy. The two working conditions of "heading" and "heading plus anti-roll" are discussed, including roll stabilization, heading error, speed maintenance and rudder abrasion. The results show that the speed can be effectively maintained using this method, and from a commercial point of view, the fin-rudder roll stabilization control is not recommended for vessels equipped with both fins and rudders.

  5. LOXL3-sv2, a novel variant of human lysyl oxidase-like 3 (LOXL3), functions as an amine oxidase.

    Science.gov (United States)

    Jeong, Chankyu; Kim, Youngho

    2017-03-01

    Human lysyl oxidase-like 3 (LOXL3) functions as a copper-dependent amine oxidase toward collagen and elastin. The LOXL3 protein contains four scavenger receptor cysteine-rich (SRCR) domains in the N-terminus in addition to the C-terminal characteristic domains of the lysyl oxidase (LOX) family, such as a copper-binding domain, a cytokine receptor‑like domain and residues for the lysyl-tyrosyl quinone cofactor. Using BLASTN searches, we identified a novel variant of LOXL3 (termed LOXL3-sv2), which lacked the sequences corresponding to exons 4 and 5 of LOXL3. The LOXL3-sv2 mRNA is at least 2,398 bp in length, encoding a 608 amino acid-long polypeptide with a calculated molecular mass of 67.4 kDa. The deletion of exons 4 and 5 do not change the open-reading frame of LOXL3 but results in deletion of the SRCR domain 2. The recombinant LOXL3-sv2 protein showed a β-aminopropionitrile-inhibitable amine oxidase activity toward collagen type I. In RT-PCR analysis, LOXL3-sv2 was detected in all human tissues tested, along with LOXL3 and LOXL3-sv1, a previously identified variant of LOXL3. These findings indicate that the human LOXL3 gene encodes at least three variants, LOXL3, LOXL3-sv1 and LOXL3-sv2, all of which function as amine oxidases.

  6. Spatial Statistics of Deep-Water Ambient Noise; Dispersion Relations for Sound Waves and Shear Waves

    Science.gov (United States)

    2015-09-30

    Propeller noise from a light aircraft for low-frequency measurements of the speed of sound in a marine sediment,” J. Comp. Acoust., 10 (4), 445-464...Dispersion Relations for Sound Waves and Shear Waves Michael J. Buckingham Marine Physical Laboratory, Scripps Institution of Oceanography University...propagation in saturated, unconsolidated marine sediments. New focus is on: 1) the dispersion associated with a frequency power law attenuation; 2) wave

  7. Acoustic gravity wave growth and damping in convecting plasma

    Directory of Open Access Journals (Sweden)

    T. R. Robinson

    Full Text Available The propagation of acoustic gravity waves through steadily convecting plasma in the thermosphere has been analysed theoretically. The growth and damping rates of internal gravity waves due to the feedback effects of wave-modulated Joule heating and Laplace forcing have been calculated. It is found that large convection flow velocities lead to the growth of large-scale internal gravity waves, whilst small- and medium-scale waves are heavily damped, under similar conditions. It has also been shown that wave growth is favoured for waves travelling against the plasma flow direction. The effects of critical coupling when wave phase speeds match the plasma flow speed have also been investigated. The results of these calculations are discussed in the context of the atmospheric energy budget and thermosphere-ionosphere coupling.

  8. Acoustic gravity wave growth and damping in convecting plasma

    Directory of Open Access Journals (Sweden)

    T. R. Robinson

    1994-01-01

    Full Text Available The propagation of acoustic gravity waves through steadily convecting plasma in the thermosphere has been analysed theoretically. The growth and damping rates of internal gravity waves due to the feedback effects of wave-modulated Joule heating and Laplace forcing have been calculated. It is found that large convection flow velocities lead to the growth of large-scale internal gravity waves, whilst small- and medium-scale waves are heavily damped, under similar conditions. It has also been shown that wave growth is favoured for waves travelling against the plasma flow direction. The effects of critical coupling when wave phase speeds match the plasma flow speed have also been investigated. The results of these calculations are discussed in the context of the atmospheric energy budget and thermosphere-ionosphere coupling.

  9. Magnetohydrodynamic waves in coronal polar plumes.

    Science.gov (United States)

    Nakariakov, Valery M

    2006-02-15

    Polar plumes are cool, dense, linear, magnetically open structures that arise from predominantly unipolar magnetic footpoints in the solar polar coronal holes. As the Alfvén speed is decreased in plumes in comparison with the surrounding medium, these structures are natural waveguides for fast and slow magnetoacoustic waves. The simplicity of the geometry of polar plumes makes them an ideal test ground for the study of magnetohydrodynamic (MHD) wave interaction with solar coronal structures. The review covers recent observational findings of compressible and incompressible waves in polar plumes with imaging and spectral instruments, and interpretation of the waves in terms of MHD theory.

  10. Nonlinear localized elastoplastic waves in a rod

    Science.gov (United States)

    Erofeev, V. I.; Leonteva, A. V.; Malkhanov, A. O.

    2017-11-01

    It has been shown that longitudinal nonlinear stationary elastic-plastic waves can be formed in a rod. Waves can be both periodic and solitary (solitons), which is determined by the index of strain hardening of the material.The velocity of propagation of such waves is less than the speed of the elastic shear wave. Along with classical solitons, so-called “embedded solitons” can be formed, that is, double solitons, one of which with a smaller amplitude and widthis located inside the other with a larger amplitude and width.

  11. Local principles of wave propagation in inhomogeneous media

    Science.gov (United States)

    Gingold, Harry; She, Jianming; Zorumski, William E.

    1993-01-01

    Four local principles are proven for waves propagating in a layered medium with a variable wave speed. These principles are (1) that inhomogeneities increase the amplitude of waves generated by a source of fixed strength, (2) that inhomogeneities reduce spatial oscillation, or increase the wavelength, (3) that inhomogeneities decrease transmission, or increase reflection, and (4) that transmission increases monotonically with frequency. Definitions of inhomogeneity, local wave function, and local reflection and transmission coefficients are made as a basis for stating these principles.

  12. Spallation and fracture resulting from reflected and intersecting stress waves.

    Science.gov (United States)

    Kinslow, R.

    1973-01-01

    Discussion of the effects of stress waves produced in solid by explosions or high-velocity impacts. These waves rebound from free surfaces in the form of tensile waves that are capable of causing internal fractures or spallation of the material. The high-speed framing camera is shown to be an important tool for observing the stress waves and fracture in transparent targets, and its photographs provide valuable information on the mechanics of fracture.

  13. Waves propagation in turbulent superfluid helium in presence of combined rotation and counterflow

    OpenAIRE

    Peruzza, Rosa Anna; Sciacca, Michele

    2010-01-01

    A complete study of the propagation of waves (namely longitudinal density and temperature waves, longitudinal and transversal velocity waves and heat waves) in turbulent superfluid helium is made in three situations: a rotating frame, a thermal counterflow, and the simultaneous combination of thermal counterflow and rotation. Our analysis aims to obtain as much as possible information on the tangle of quantized vortices from the wave speed and attenuation factor of these different waves, depe...

  14. Scanning high-power continuous wave laser-generated bulk acoustic waves.

    Science.gov (United States)

    Li, Zheng; Yan, Shiling; Xie, Qingnan; Ni, Chenyin; Shen, Zhonghua

    2017-05-20

    The ultrasonic bulk waves generated by a high-power continuous laser scanning along the surface of aluminum material were theoretically investigated. Although the temperature rise generated by this scanning laser irradiation was small, it provided a large temperature gradient, which was able to generate measurable ultrasonic waves. Detailed discussions were given to the influence of scanning speed on the generation propagation direction and the amplitude of the wavefront. The longitudinal and transverse waves would be generated in the material only when the scanning speeds reached a certain range. What's more, the amplitude of the wavefronts were significantly enhanced if the wavefront angle controlled by the scanning speed matched with the propagation direction of the ultrasound. In summary, it expounded a method to obtain the ultrasonic signal of direction, controlled from the perspective of numerical simulation, as long as the scanning speed met the requirements.

  15. Speed enforcement in Norway

    DEFF Research Database (Denmark)

    Elvik, Rune

    2015-01-01

    the game-theoretic model empirically. Testing the model rigorously is difficult, mainly because some of the relevant variables are not reliably measured and are endogenous. Two models were developed: one to identify sources of changes in the rate of violations, one to identify sources of changes......This paper probes the relationship between changes in the risk of apprehension for speeding in Norway and changes in the amount of speeding. The paper is based on a game-theoretic model of how the rate of violations and the amount of enforcement is determined by the interaction between drivers...... and the police. This model makes predictions both about how drivers will adapt to changes in the amount of enforcement (the more enforcement, the less violations) as well as how the police will adapt to changes in the rate of violations (the less violations, the less enforcement). The paper attempts to test...

  16. Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL/6J and 129X1/SvJ mice

    Science.gov (United States)

    Wu, Ruirui; Wu, Xiafang; Wang, Huihui; Fang, Xin; Li, Yongfang; Gao, Lanyue; Sun, Guifan; Pi, Jingbo; Xu, Yuanyuan

    2017-03-01

    Arsenic is a common environmental and occupational toxicant with dramatic species differences in its susceptibility and metabolism. Mouse strain variability may provide a better understanding of the arsenic pathological profile but is largely unknown. Here we investigated oxidative lesion induced by acute arsenic exposure in the two frequently used mouse strains C57BL/6J and 129X1/SvJ in classical gene targeting technique. A dose of 5 mg/kg body weight arsenic led to a significant alteration of blood glutathione towards oxidized redox potential and increased hepatic malondialdehyde content in C57BL/6J mice, but not in 129X1/SvJ mice. Hepatic antioxidant enzymes were induced by arsenic in transcription in both strains and many were higher in C57BL/6J than 129X1/SvJ mice. Arsenic profiles in the liver, blood and urine and transcription of genes encoding enzymes involved in arsenic biomethylation all indicate a higher arsenic methylation capacity, which contributes to a faster hepatic arsenic excretion, in 129X1/SvJ mice than C57BL/6J mice. Taken together, C57BL/6J mice are more susceptible to oxidative hepatic injury compared with 129X1/SvJ mice after acute arsenic exposure, which is closely associated with arsenic methylation pattern of the two strains.

  17. Comparative transcriptome profiling of an SV40-transformed human fibroblast (MRC5CVI and its untransformed counterpart (MRC-5 in response to UVB irradiation.

    Directory of Open Access Journals (Sweden)

    Cheng-Wei Chang

    Full Text Available Simian virus 40 (SV40 transforms cells through the suppression of tumor-suppressive responses by large T and small t antigens; studies on the effects of these two oncoproteins have greatly improved our knowledge of tumorigenesis. Large T antigen promotes cellular transformation by binding and inactivating p53 and pRb tumor suppressor proteins. Previous studies have shown that not all of the tumor-suppressive responses were inactivated in SV40-transformed cells; however, the underlying cause is not fully studied. In this study, we investigated the UVB-responsive transcriptome of an SV40-transformed fibroblast (MRC5CVI and that of its untransformed counterpart (MRC-5. We found that, in response to UVB irradiation, MRC-5 and MRC5CVI commonly up-regulated the expression of oxidative phosphorylation genes. MRC-5 up-regulated the expressions of chromosome condensation, DNA repair, cell cycle arrest, and apoptotic genes, but MRC5CVI did not. Further cell death assays indicated that MRC5CVI was more sensitive than MRC-5 to UVB-induced cell death with increased caspase-3 activation; combining with the transcriptomic results suggested that MRC5CVI may undergo UVB-induced cell death through mechanisms other than transcriptional regulation. Our study provides a further understanding of the effects of SV40 transformation on cellular stress responses, and emphasizes the value of SV40-transformed cells in the researches of sensitizing neoplastic cells to radiations.

  18. An Energy Budget Model to Calculate the Low Atmosphere Profiles of Effective Sound Speed at Night

    National Research Council Canada - National Science Library

    Tunick, Arnold

    2003-01-01

    ...) for generating low atmosphere profiles of effective sound speed at night. The alternate model is based on the solution of a quartic equation for surface temperature, which assumes a balance between the net long wave...

  19. Simulations of short-crested harbour waves with variational Boussinesq modelling

    NARCIS (Netherlands)

    Adytia, D.

    2014-01-01

    Waves propagating from the deep ocean to the coast show large changes in wave height, wave length and direction. The challenge to simulate the essential wave characteristics is in particular to model the speed and nonlinear interaction correctly. All these physical phenomena are present, but hidden,

  20. Dispersion of Own Frequency of Ion-Dipole by Supersonic Transverse Wave in Solid

    Directory of Open Access Journals (Sweden)

    Minasyan V.

    2010-10-01

    Full Text Available First, we predict an existence of transverse electromagnetic field formed by supersonic transverse wave in solid. This electromagnetic wave acquires frequency and speed of sound, and it propagates along of direction propagation of supersonic wave. We also show that own frequency of ion-dipole depends on frequency of supersonic transverse wave.

  1. Obtaining thickness profiles from the tomographic inversion of guided wave data

    NARCIS (Netherlands)

    Bloom, J.G.P.; Luiten, E.A.; Volker, A.W.F.

    2009-01-01

    Guided wave tomography is a promising technique for the monitoring of corrosion over large areas. Guided waves have a wave speed mat depends in certain frequency-thickness regimes on the local thickness of the waveguide they follow. Therefore, the travel time of the guided wave over a fixed distance

  2. Observations of wind and waves in the central Bay of Bengal during ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    during its transmission in the surface duct. The present analysis aiming for estimation .... 20minute period is used for computing the signif- icant wave height (Hs) and period (Ts) .... Variations of wind speed, significant wave height, significant wave period and mixed-layer depth in the central. Bay of Bengal. swell waves from ...

  3. Equilibrium Investment Strategy for DC Pension Plan with Inflation and Stochastic Income under Heston’s SV Model

    Directory of Open Access Journals (Sweden)

    Jingyun Sun

    2016-01-01

    Full Text Available We consider a portfolio selection problem for a defined contribution (DC pension plan under the mean-variance criteria. We take into account the inflation risk and assume that the salary income process of the pension plan member is stochastic. Furthermore, the financial market consists of a risk-free asset, an inflation-linked bond, and a risky asset with Heston’s stochastic volatility (SV. Under the framework of game theory, we derive two extended Hamilton-Jacobi-Bellman (HJB equations systems and give the corresponding verification theorems in both the periods of accumulation and distribution of the DC pension plan. The explicit expressions of the equilibrium investment strategies, corresponding equilibrium value functions, and the efficient frontiers are also obtained. Finally, some numerical simulations and sensitivity analysis are presented to verify our theoretical results.

  4. Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose

    DEFF Research Database (Denmark)

    Øvrehus, Kristian Altern; Schuhbaeck, Annika; Marwan, Mohamed

    2015-01-01

    or response to medical therapies. The reproducibility from repeated assessment of such quantitative measurements from low-radiation dose coronary CTA has not been previously assessed. Purpose: To evaluate the interscan, interobserver and intraobserver reproducibility for coronary plaque volume assessment...... using semi-automatic plaque analyses algorithm in low radiation dose coronary CTA. Methods: In 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days with a mean radiation dose of 0.7 mSv per coronary CTA, the interscan, interobserver and intraobserver reproducibility.......6% and +/- 32.1%, respectively. Conclusion: A semi-automatic plaque assessment algorithm in repeated low radiation dose coronary CTA allows for high reproducibility of coronary plaque characterization and quantification measures. (C) 2016 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc...

  5. Inhibition of multidrug resistance by SV40 pseudovirion delivery of an antigene peptide nucleic acid (PNA in cultured cells.

    Directory of Open Access Journals (Sweden)

    Benjamin Macadangdang

    Full Text Available Peptide nucleic acid (PNA is known to bind with extraordinarily high affinity and sequence-specificity to complementary nucleic acid sequences and can be used to suppress gene expression. However, effective delivery into cells is a major obstacle to the development of PNA for gene therapy applications. Here, we present a novel method for the in vitro delivery of antigene PNA to cells. By using a nucleocapsid protein derived from Simian virus 40, we have been able to package PNA into pseudovirions, facilitating the delivery of the packaged PNA into cells. We demonstrate that this system can be used effectively to suppress gene expression associated with multidrug resistance in cancer cells, as shown by RT-PCR, flow cytometry, Western blotting, and cell viability under chemotherapy. The combination of PNA with the SV40-based delivery system is a method for suppressing a gene of interest that could be broadly applied to numerous targets.

  6. Diversity of methane-producing microbial community structure with 16S-V3 rDNA PCR-DGGE

    Directory of Open Access Journals (Sweden)

    Na Wang

    2016-01-01

    Full Text Available The method of 16S-V3 rDNA PCR-DGGE was utilized to study the diversity of methane-producing microbial community structure under different methane-producing microbial community structure. Results showed that community structure of the methanogens under different environmental condition was significantly different. The number of bands about community under extreme condition was less than normal conditions, but the main bands were obvious. The sequence analysis showed that the predominant strains mainly were uncultured bacteria that could not be identified in the level of species .Z2 was Clostridia, Z8 was Clostridiales, D5 was Eubacteriaceae, and D8 was Flavobacteriaceae. This study laid some extent foundation for future research about establishing a methane-producing bacterial system with high gas yield in winter.

  7. Napájecí zdroj pro kyslíkovodíkovou svářečku

    OpenAIRE

    Kalus, Jiří

    2016-01-01

    Diplomová práce se zabývá problematikou návrhu napájecího zdroje elektrolyzéru pro plynovou svářečku na bázi vodíku a kyslíku. Hlavní náplní práce je návrh tohoto zdroje, který bude realizován jako spínaný. Což vede k menším rozměrům a hmotnosti. Práce obsahuje návrh DPS a naměřené parametry zdroje. Master´s thesis deals with design of oxy-hydrogen generator power supply for gas welder. Main topic of this thesis is a design of switching mode power supply, which leads to smaller dimensions ...

  8. Cellular ras gene activity is required for full neoplastic transformation by the large tumor antigen of SV40.

    Science.gov (United States)

    Raptis, L; Brownell, H L; Corbley, M J; Wood, K W; Wang, D; Haliotis, T

    1997-08-01

    To investigate the role of the cellular ras gene product in neoplastic transformation by the SV40 large tumor antigen (SVLT), murine C3H10T1/2 cells were rendered deficient in Ras activity by transfection with inducible or constitutive antisense ras gene constructs or through the introduction of the dominant-negative mutant, ras(asn17). Consistent with previous results, SVLT-induced morphological transformation was unaffected by the down-regulation of c-ras gene product activity. On the other hand, colony formation in soft agar and tumorigenicity in nude mice were drastically reduced in c-Ras-deficient cells. In addition, SVLT expression in C3H10T1/2 cells led to increased c-Ras activity, as determined by an increase in the Ras-bound GTP/GTP + GDP ratio. These results suggest that c-Ras is required for full neoplastic transformation by SVLT.

  9. Effects of high sound speed confiners on ANFO detonations

    Science.gov (United States)

    Kiyanda, Charles; Jackson, Scott; Short, Mark

    2011-06-01

    The interaction between high explosive (HE) detonations and high sound speed confiners, where the confiner sound speed exceeds the HE's detonation speed, has not been thoroughly studied. The subsonic nature of the flow in the confiner allows stress waves to travel ahead of the main detonation front and influence the upstream HE state. The interaction between the detonation wave and the confiner is also no longer a local interaction, so that the confiner thickness now plays a significant role in the detonation dynamics. We report here on larger scale experiments in which a mixture of ammonium nitrate and fuel oil (ANFO) is detonated in aluminium confiners with varying charge diameter and confiner thickness. The results of these large-scale experiments are compared with previous large-scale ANFO experiments in cardboard, as well as smaller-scale aluminium confined ANFO experiments, to characterize the effects of confiner thickness.

  10. Swimming Speeds of Filaments in Viscous Fluids with Resistance

    Science.gov (United States)

    Ho, Nguyenho; Olson, Sarah

    2015-11-01

    Spermatozoa and bacteria can utilize lateral and spiral bending waves to propagate in a fluid. Often, they encounter different fluid environments filled with mucus, cells, hormones, and other large proteins. These extra materials act as friction, possibly preventing or enhancing forward progression of swimmers. To understand these effects, we employ Taylor's techniques to calculate the asymptotic swimming speeds of a cylinder of infinite extent in a viscous fluid with resistance known as a Brinkman fluid. We find that, up to the second order expansion, the swimming speeds are enhanced as resistance increases. The Stokes limit can also be also recovered from this result as resistance goes to zero. In addition, we show numerical results for a Lagrangian algorithm of a rod waving in a porous medium and compare numerical results to asymptotic swimming speeds.

  11. Ultrasonic guided wave nondestructive evaluation using generalized anisotropic interface waves

    Science.gov (United States)

    Gardner, Michael D.

    The motivation for this work is a goal to inspect interfaces between thick layers of materials that can be anisotropic. The specific application is a thick composite bonded to a metal substrate. The interface is inspected for disbonds between the metal and composite. The large thickness allows the problem to be modeled as a half space. The theory behind guided waves in plates is presented. This theory includes the calculation and analysis of dispersion curves and the resulting wave structure. It is noted that for high frequency-thickness values, certain modes will converge to the half-space waves, e.g. the Rayleigh wave and the Stoneley wave. Points of high energy, especially shear energy, at the interface are desirable for interfacial inspection. Therefore, the wave structure for all modes and frequencies is searched for ideal inspection points. Interface waves are inherently good modes to use for interface inspection. Results from the dispersion curves and wave structures are verified in the finite element model software package called Abaqus. It is confirmed that the group speeds and wave structures of the modes match the predicted values. A theoretical development of interface waves is given wherein Rayleigh, Stoneley, and generalized interface waves are discussed. This is applied to both isotropic and anisotropic materials. It is shown that the Stoneley wave only exists for a certain range of material parameters. Because the Stoneley wave is the interface wave between two solid half spaces, it might appear that only certain pairs of solids would allow for inspection via interface wave. However, it is shown that for perturbations of the Stoneley-wave-valid material properties, interface waves which leak energy away from the interface can still propagate. They can also be used for inspection. Certain choices of materials will leak less energy and will therefore allow for longer inspection distances. The solutions to the isotropic leaky wave problem exist on

  12. High-speed non-contact defect imaging for a plate-like structure

    OpenAIRE

    Hayashi, Takahiro

    2017-01-01

    Images of defects in a plate-like structure can be obtained from amplitude distributions measured using the scanning laser source technique. This paper discusses high-speed non-contact imaging for defects in a plate. Fundamental experiments conducted using a contact piezoelectric transducer as a receiving device revealed the effect of the generated wave shape and measurement speed on the defect images. Generating tone-burst waves consisting of multiple frequency components and averaging the i...

  13. Consolidation Waves

    OpenAIRE

    Berg, Ward; Smit, Han

    2007-01-01

    textabstractThis paper explains why consolidation acquisitions occur in waves and it predicts the differing role each firm is likely to play in the consolidation game. We propose that whether a firm assumes the role of rival consolidator, target, or passive observer depends on the position of the firm relative to the entity that merges first. Our model predicts that an initial acquisition triggers a wave of follow-on acquisitions, where the process of asset accumulation by the consolidator is...

  14. Wave Star

    DEFF Research Database (Denmark)

    Kramer, Morten; Andersen, Thomas Lykke

    Nærværende rapport beskriver modelforsøg udført på Aalborg Universitet, Institut for Vand, Jord og Miljøteknik med bølgeenergianlægget Wave Star.......Nærværende rapport beskriver modelforsøg udført på Aalborg Universitet, Institut for Vand, Jord og Miljøteknik med bølgeenergianlægget Wave Star....

  15. Wave Star

    DEFF Research Database (Denmark)

    Kramer, Morten; Frigaard, Peter

    Nærværende rapport beskriver modelforsøg udført på Aalborg Universitet, Institut for Byggeri og Anlæg med bølgeenergianlæget Wave Star.......Nærværende rapport beskriver modelforsøg udført på Aalborg Universitet, Institut for Byggeri og Anlæg med bølgeenergianlæget Wave Star....

  16. Blast Waves

    CERN Document Server

    Needham, Charles E

    2010-01-01

    The primary purpose of this text is to document many of the lessons that have been learned during the author’s more than forty years in the field of blast and shock. The writing therefore takes on an historical perspective, in some sense, because it follows the author’s experience. The book deals with blast waves propagating in fluids or materials that can be treated as fluids. It begins by distinguishing between blast waves and the more general category of shock waves. It then examines several ways of generating blast waves, considering the propagation of blast waves in one, two and three dimensions as well as through the real atmosphere. One section treats the propagation of shocks in layered gases in a more detailed manner. The book also details the interaction of shock waves with structures in particular reflections, progressing from simple to complex geometries, including planar structures, two-dimensional structures such as ramps or wedges, reflections from heights of burst, and three-dimensional st...

  17. DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc.

    Science.gov (United States)

    Kim, Yun Chul; Kitaura, Hirotake; Iguchi-Ariga, Sanae M M; Ariga, Hiroyoshi

    2010-09-24

    Simian virus 40 (SV40) is a tumor virus and its early gene product large T-antigen (LT) is responsible for the transforming activity of SV40. Parkinson's disease causative gene DJ-1 is also a ras-dependent oncogene, but the mechanism of its oncogene function is still not known. In this study, we found that there were no transformed foci when fibroblasts from DJ-1-knockout mice were transfected with LT. We also found that DJ-1 directly bound to LT and that the expression level of c-Myc in transformed cells was parallel to that of DJ-1. These findings indicate that DJ-1 is essential for SV40 transformation. Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

  18. The role of visual processing speed in reading speed development.

    Science.gov (United States)

    Lobier, Muriel; Dubois, Matthieu; Valdois, Sylviane

    2013-01-01

    A steady increase in reading speed is the hallmark of normal reading acquisition. However, little is known of the influence of visual attention capacity on children's reading speed. The number of distinct visual elements that can be simultaneously processed at a glance (dubbed the visual attention span), predicts single-word reading speed in both normal reading and dyslexic children. However, the exact processes that account for the relationship between the visual attention span and reading speed remain to be specified. We used the Theory of Visual Attention to estimate visual processing speed and visual short-term memory capacity from a multiple letter report task in eight and nine year old children. The visual attention span and text reading speed were also assessed. Results showed that visual processing speed and visual short term memory capacity predicted the visual attention span. Furthermore, visual processing speed predicted reading speed, but visual short term memory capacity did not. Finally, the visual attention span mediated the effect of visual processing speed on reading speed. These results suggest that visual attention capacity could constrain reading speed in elementary school children.

  19. Pay as You Speed, ISA with incentive for not speeding

    DEFF Research Database (Denmark)

    Lahrmann, Harry Spaabæk; Agerholm, Niels; Tradisauskas, Nerius

    2012-01-01

    , with and without incentive crossed with informative ISA present or absent. The results showed that ISA is an efficient tool for reducing speeding particularly on rural roads. The analysis of speed data demonstrated that the proportion of distance driven above the speed where the ISA equipment responded (PDA...

  20. The role of visual processing speed in reading speed development.

    Directory of Open Access Journals (Sweden)

    Muriel Lobier

    Full Text Available A steady increase in reading speed is the hallmark of normal reading acquisition. However, little is known of the influence of visual attention capacity on children's reading speed. The number of distinct visual elements that can be simultaneously processed at a glance (dubbed the visual attention span, predicts single-word reading speed in both normal reading and dyslexic children. However, the exact processes that account for the relationship between the visual attention span and reading speed remain to be specified. We used the Theory of Visual Attention to estimate visual processing speed and visual short-term memory capacity from a multiple letter report task in eight and nine year old children. The visual attention span and text reading speed were also assessed. Results showed that visual processing speed and visual short term memory capacity predicted the visual attention span. Furthermore, visual processing speed predicted reading speed, but visual short term memory capacity did not. Finally, the visual attention span mediated the effect of visual processing speed on reading speed. These results suggest that visual attention capacity could constrain reading speed in elementary school children.

  1. Pay as You Speed, ISA with incentives for not speeding

    DEFF Research Database (Denmark)

    Lahrmann, Harry Spaabæk; Agerholm, Niels; Tradisauskas, Nerius

    2012-01-01

    The Intelligent Speed Adaptation (ISA) project we describe in this article is based on Pay as You Drive principles. These principles assume that the ISA equipment informs a driver of the speed limit, warns the driver when speeding and calculates penalty points. Each penalty point entails the redu...

  2. Flame speed enhancement of a nitrocellulose monopropellant using graphene microstructures

    Science.gov (United States)

    Jain, S.; Park, W.; Chen, Y. P.; Qiao, L.

    2016-11-01

    The control and enhancement of the combustion wave propagation velocities of solid monopropellants are very important for the development of low cost and efficient micro power systems such as microthrusters and thermal-to-electrical energy conversion devices. In this work, the flame speed enhancement of a nitrocellulose (NC) solid monopropellant using highly conductive graphene structures was demonstrated. Two different graphene structures, namely, graphene foam (GF) and graphene nano-pellets (GNPs), were studied. For the GNP-doped NC films, fuel layers 500 ± 30 μm thick were deposited and the doping concentrations were varied from 1% to 5% by mass. For the GF, the fuel loading ratio (%) and the foam density were varied to study their effect on the flame speed propagation behavior. Self-propagating combustion waves were observed, with average flame speed enhancements up to 8 times the bulk value. The flame speed enhancement, for both the GNPs and the GF, showed a parabolic trend as a function of their concentrations, and an optimum value for each case was determined. However, the flame speed enhancement, as a function of the GF density (for a fixed fuel loading ratio), showed a monotonic decreasing trend. Moreover, the reusability of the GF structures was also tested by re-depositing them with fuel after combustion. Similar flame speed enhancement was obtained using the fresh and the re-used GF structures.

  3. Algorithm for wind speed estimate with polarimetric radar

    Directory of Open Access Journals (Sweden)

    Ю. А. Авер’янова

    2013-07-01

    Full Text Available The connection of wind speed and drops behavior is substantiated as well as the drop behavior influence onto the polarization characteristics of electromagnetic waves. The expression to calculate the wind speed taking into account the Weber number for the critical regime of drop deformation is obtained. The critical regime of drop deformation is the regime when drop is divided into two parts. The dependency of critical wind speed on the drop diameter is calculated and shown. The concept o polarization spectrum that is introduced in the previous papers is used to estimate the dynamic processes in the atmosphere. At the moment when the drop is under the influence of the wind that is equal to the critical wind speed the drop will be divided into two parts. This process will be reflected as the appearance of the two equal components of polarization spectra of reflected electromagnetic waves at the orthogonal antennas of Doppler Polarimetric Radar. Owing the information about the correspondence of the polarization component energy level to the drop diameter it is possible to estimate the wind speed with the obtained dependency. The process of the wind speed estimate with polarimetric radar is presented with the developed common algorithm

  4. Wave Generation Theory

    DEFF Research Database (Denmark)

    Frigaard, Peter; Høgedal, Michael; Christensen, Morten

    The intention of this manual is to provide some formulas and techniques which can be used for generating waves in hydraulic laboratories. Both long crested waves (2-D waves) and short crested waves (3-D waves) are considered....

  5. Millimeter-wave antennas configurations and applications

    CERN Document Server

    du Preez, Jaco

    2016-01-01

    This book comprehensively reviews the state of the art in millimeter-wave antennas, traces important recent developments and provides information on a wide range of antenna configurations and applications. While fundamental theoretical aspects are discussed whenever necessary, the book primarily focuses on design principles and concepts, manufacture, measurement techniques, and practical results. Each of the various antenna types scalable to millimeter-wave dimensions is considered individually, with coverage of leaky-wave and surface-wave antennas, printed antennas, integrated antennas, and reflector and lens systems. The final two chapters address the subject from a systems perspective, providing an overview of supporting circuitry and examining in detail diverse millimeter-wave applications, including high-speed wireless communications, radio astronomy, and radar. The vast amount of information now available on millimeter-wave systems can be daunting for researchers and designers entering the field. This b...

  6. Maestro di Pico i iluminacije u inkunabuli De Civitate Dei (Nicolas Jenson, Venecija, 1475.) u samostanu Sv. Duje u Kraju na Pašmanu

    OpenAIRE

    Goja, Bojan

    2014-01-01

    U franjevačkom samostanu Sv. Duje u Kraju na otoku Pašmanu čuva se inkunabula „O državi Božjoj“ (De Civitate Dei) Sv. Aurelija Augustina koju je 1475. godine u Veneciji tiskao Nicolas Jenson. Inkunabula je na f. 17 (kako je naknadno označena paginacija grafitnom olovkom, tj. stranici incipita – liber primus) kao i na više drugih stranica ukrašena lijepim višebojnim iluminacijama renesansnih stilskih karakteristika izrađenih temperom, zlatnim listićima, zlatnim prahom, sepijom, tintom i akvare...

  7. Tropical cyclogenesis in a tropical wave critical layer: easterly waves

    Science.gov (United States)

    Dunkerton, T. J.; Montgomery, M. T.; Wang, Z.

    2008-06-01

    The development of tropical depressions within tropical waves over the Atlantic and eastern Pacific is usually preceded by a "surface low along the wave" as if to suggest a hybrid wave-vortex structure in which flow streamlines not only undulate with the waves, but form a closed circulation in the lower troposphere surrounding the low. This structure, equatorward of the easterly jet axis, resembles the familiar critical layer of waves in shear flow, a flow configuration which arguably provides the simplest conceptual framework for tropical cyclogenesis resulting from tropical waves, their interaction with the mean flow, and with diabatic processes associated with deep moist convection. The critical layer represents a sweet spot for tropical cyclogenesis in which a proto-vortex may form and grow within its parent wave. A common location for storm development within the critical layer is given by the intersection of the wave's critical latitude and trough axis, with analyzed vorticity centroid nearby. The wave and vortex live together for a time, and initially propagate at approximately the same speed. In most cases this coupled propagation continues for a few days after a tropical depression is identified. For easterly waves, as the name suggests, the propagation is westward. It is shown that in order to visualize optimally this "marsupial paradigm" one should view the flow streamlines, or stream function, in a frame of reference translating horizontally with the phase propagation of the parent wave. This translation requires an appropriate "gauge" that renders translating streamlines and isopleths of translating stream function approximately equivalent to flow trajectories. In the translating frame, the closed circulation is stationary, and a dividing streamline effectively separates air within the critical layer from air outside. The critical layer equatorward of the easterly jet axis is important to tropical cyclogenesis because it provides (i) a region of

  8. Direct Measurement of the Speed of Sound Using a Microphone and a Speaker

    Science.gov (United States)

    Gómez-Tejedor, José A.; Castro-Palacio, Juan C.; Monsoriu, Juan A.

    2014-01-01

    We present a simple and accurate experiment to obtain the speed of sound in air using a conventional speaker and a microphone connected to a computer. A free open source digital audio editor and recording computer software application allows determination of the time-of-flight of the wave for different distances, from which the speed of sound is…

  9. A Torque Discontinuity Free New Hybrid PWM Approach for High Speed Induction Motor Drives

    Directory of Open Access Journals (Sweden)

    Habibur Rehman

    2014-01-01

    Full Text Available This paper designs a hybrid speed controller in which a Sine Triangle Pulse Width Modulated (SPWM inverter is used below the base speed and a square wave inverter is employed above the base speed. The two inversion techniques complement each other for their advantages and disadvantages below and above the base speed. This paper proposes a unique strategy for the transition between SPWM and square wave by simply setting the frequency of the carrier signal equal to zero. The proposed methodology in a way uses only one inversion technique and realizes a seamless transition from the SPWM to square wave compared to conventional method in which modes are simply switched from SPWM to square wave and vice versa when the speed changes above and below the base speed, respectively. Computer simulations show that the proposed technique has smoother torque transition and thus a better speed response compared to conventional approach of inverter mode switching around the base speed. The performance of proposed hybrid approach is also validated on a small prototype induction motor through experimental results.

  10. A Model of Cognitive Speed.

    Science.gov (United States)

    Fulford, Catherine P.

    2001-01-01

    Introduces a model of cognitive speed and considers its relevance to research and practice. Topics include information processing; semantic cognitive flow; compressed speech; speed-reading; cognitive speed and interaction; and implications for distance education, video multimedia, computer-assisted instruction, hypermedia, interactive multimedia,…

  11. Guidelines for setting speed limits

    CSIR Research Space (South Africa)

    Wium, DJW

    1986-02-01

    Full Text Available A method is described for setting the speed limit for a particular road section. Several speed limits based on different criteria are described for each of nine traffic and road factors. The most appropriate speed limit for each relevant factor...

  12. Speed control variable rate irrigation

    Science.gov (United States)

    Speed control variable rate irrigation (VRI) is used to address within field variability by controlling a moving sprinkler’s travel speed to vary the application depth. Changes in speed are commonly practiced over areas that slope, pond or where soil texture is predominantly different. Dynamic presc...

  13. Photoacoustic microscopy of blood pulse wave

    OpenAIRE

    Yeh, Chenghung; Hu, Song; Maslov, Konstantin; Wang, Lihong V.

    2012-01-01

    Blood pulse wave velocity (PWV) is an important physiological parameter that characterizes vascular stiffness. In this letter, we present electrocardiogram-synchronized, photoacoustic microscopy for noninvasive quantification of the PWV in the peripheral vessels of living mice. Interestingly, blood pulse wave-induced fluctuations in blood flow speed were clearly observed in arteries and arterioles, but not in veins or venules. Simultaneously recorded electrocardiograms served as references to...

  14. Space-time fractional Zener wave equation.

    Science.gov (United States)

    Atanackovic, T M; Janev, M; Oparnica, Lj; Pilipovic, S; Zorica, D

    2015-02-08

    The space-time fractional Zener wave equation, describing viscoelastic materials obeying the time-fractional Zener model and the space-fractional strain measure, is derived and analysed. This model includes waves with finite speed, as well as non-propagating disturbances. The existence and the uniqueness of the solution to the generalized Cauchy problem are proved. Special cases are investigated and numerical examples are presented.

  15. Space–time fractional Zener wave equation

    Science.gov (United States)

    Atanackovic, T.M.; Janev, M.; Oparnica, Lj.; Pilipovic, S.; Zorica, D.

    2015-01-01

    The space–time fractional Zener wave equation, describing viscoelastic materials obeying the time-fractional Zener model and the space-fractional strain measure, is derived and analysed. This model includes waves with finite speed, as well as non-propagating disturbances. The existence and the uniqueness of the solution to the generalized Cauchy problem are proved. Special cases are investigated and numerical examples are presented. PMID:25663807

  16. Efficient Wave Energy Amplification with Wave Reflectors

    OpenAIRE

    Kramer, Morten Mejlhede; Frigaard, Peter Bak

    2002-01-01

    Wave Energy Converters (WEC's) extract wave energy from a limited area, often a single point or line even though the wave energy is generally spread out along the wave crest. By the use of wave reflectors (reflecting walls) the wave energy is effectively focused and increased to approximately 130-140%. In the paper a procedure for calculating the efficiency and optimizing the geometry of wave reflectors are described, this by use of a 3D boundary element method. The calculations are verified ...

  17. Simulation of Wind Speed in the Ventilation Tunnel for Surge Tanks in Transient Processes

    Directory of Open Access Journals (Sweden)

    Jiandong Yang

    2016-02-01

    Full Text Available Hydroelectric power plants’ open-type surge tanks may be built in mountains subject to the provision of atmospheric air. Hence, a ventilation tunnel is indispensable. The air flow in the ventilation tunnel is associated with the fluctuation of water-level in the surge tank. There is a great relationship between the wind speed and the safe use and project investment of ventilation tunnels. To obtain the wind speed in a ventilation tunnel for a surge tank during transient processes, this article adopts the one-dimensional numerical simulation method and establishes a mathematical model of a wind speed by assuming the boundary conditions of air discharge for a surge tank. Thereafter, the simulation of wind speed in a ventilation tunnel, for the case of a surge tank during transient processes, is successfully realized. Finally, the effective mechanism of water-level fluctuation in a surge tank and the shape of the ventilation tunnel (including length, sectional area and dip angle for the wind speed distribution and the change process are discovered. On the basis of comparison between the simulation results of 1D and 3D computational fluid dynamics (CFD, the results indicate that the one-dimensional simulation method as proposed in this article can be used to accurately simulate the wind speed in the ventilation tunnel of a surge tank during transient processes. The wind speed fluctuations can be superimposed by using the low frequency mass wave (i.e., fundamental wave and the high frequency elastic wave (i.e., harmonic wave. The water-level fluctuation in a surge tank and the sectional area of the ventilation tunnel mainly affect the amplitude of fundamental and harmonic waves. The period of a fundamental wave can be determined from the water-level fluctuations. The length of the ventilation tunnel has an effect on the period and amplitude of harmonic waves, whereas the dip angle influences the amplitude of harmonic waves.

  18. Wave propagation in ballistic gelatine.

    Science.gov (United States)

    Naarayan, Srinivasan S; Subhash, Ghatu

    2017-04-01

    Wave propagation characteristics in long cylindrical specimens of ballistic gelatine have been investigated using a high speed digital camera and hyper elastic constitutive models. The induced transient deformation is modelled with strain rate dependent Mooney-Rivlin parameters which are determined by modelling the stress-strain response of gelatine at a range of strain rates. The varying velocity of wave propagation through the gelatine cylinder is derived as a function of prestress or stretch in the gelatine specimen. A finite element analysis is conducted using the above constitutive model by suitably defining the impulse imparted by the polymer bar into the gelatine specimen. The model results are found to capture the experimentally observed wave propagation characteristics in gelatine effectively. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Should We Bother with the Speed of Light in Everyday Life? A Closer Look at GSM Technology

    Science.gov (United States)

    Kawalec, Tomasz

    2012-01-01

    The speed of light, or more generally, the speed of electromagnetic waves, seems to be incredibly high. 300 000 km s[superscript -1] is far greater than the typical speed of a car, a plane or even a rocket, which is just several kilometres per second. It is thus natural that we treat the speed of light as infinite in everyday life. It appears,…

  20. Fetal bovine serum and human constitutive androstane receptor: Evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system

    Energy Technology Data Exchange (ETDEWEB)

    Lau, Aik Jiang; Chang, Thomas K.H., E-mail: thomas.chang@ubc.ca

    2014-06-01

    The naturally occurring SV23 splice variant of human constitutive androstane receptor (hCAR-SV23) is activated by di-(2-ethylhexyl)phthalate (DEHP), which is detected as a contaminant in fetal bovine serum (FBS). In our initial experiment, we compared the effect of dialyzed FBS, charcoal-stripped, dextran-treated FBS (CS-FBS), and regular FBS on the basal activity and ligand-activation of hCAR-SV23 in a cell-based reporter gene assay. In transfected HepG2 cells cultured in medium supplemented with 10% FBS, basal hCAR-SV23 activity varied with the type of FBS (regular > dialyzed > CS). DEHP increased hCAR-SV23 activity when 10% CS-FBS, but not regular FBS or dialyzed FBS, was used. With increasing concentrations (1–10%) of regular FBS or CS-FBS, hCAR-SV23 basal activity increased, whereas in DEHP-treated cells, hCAR-SV23 activity remained similar (regular FBS) or slightly increased (CS-FBS). Subsequent experiments identified a serum-free culture condition to detect DEHP activation of hCAR-SV23. Under this condition, artemisinin, artemether, and arteether increased hCAR-SV23 activity, whereas they decreased it in cells cultured in medium supplemented with 10% regular FBS. By comparison, FBS increased the basal activity of the wild-type isoform of hCAR (hCAR-WT), whereas it did not affect the basal activity of the SV24 splice variant (hCAR-SV24) or ligand activation of hCAR-SV24 and hCAR-WT by 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (CITCO). The use of serum-free culture condition was suitable for detecting CITCO activation of hCAR-WT and hCAR-SV24. In conclusion, FBS leads to erroneous classification of pharmacological ligands of hCAR-SV23 in cell-based assays, but investigations on functional ligands of hCAR isoforms can be conducted in serum-free culture condition. - Highlights: • FBS leads to erroneous pharmacological classification of hCAR-SV23 ligands. • Artemisinin, artemether, and arteether activate hCAR-SV

  1. Níveis de sensibilidade de enterobactérias, em particular Salmonella typhi, a rifamicina S.V.

    Directory of Open Access Journals (Sweden)

    Ivone R. Suassuna

    1969-04-01

    Full Text Available Em face à predominante eliminação biliar da rifamicina S.V. atingindo concentrações muitas vêzes superiores aos níveis séricos obtidos com as doses terapêuticas, e pelo possível interêsse dessa verificação para o tratamento dos portadores biliares crônicos de Salmonella typhi determinou-se a concentração mínima inibitória de 165 estirpes de enterobactérias, incluindo 77 amostras de S. typhi. Foi verificado que a maioria das cepas de Escherichia coli, Shigella e Proteus mirabilis correspondiam a uma concentração inibitória mínima entre 33 a 65 μg/ml. Entre 65 e 128 μg/ml foram determinadas as concetrações inibitórias mínimas da maioria das outras espécies de Proteus, de Providencia e de Klebsiella. Para Salmonella e Enterobacter o limite mínino de sensibilidade foi, em regra, igual ou superior a 128 μg/ml. Diferenças mais acentuadas de comportamento entre as enterobactérias foram observadas quanto à ação bactericida da rifamicidas S.V. De uma maneira geral, para E. coli e Shigella, as concentrações inibitórias mínimas já referidas. Para as espécies de Proteus e Providencia houve variação maior de comportamento, mas tendência a que o efeito bactericidas fôsse encontrado em concentrações que correspondiam a 4 vêzes as bacteriostáticas para as mesmas espécies. Finalmente, de modo pouco feliz para os propósitos visados, em Salmonella, com a inclusão de S. typhi, não foi atingido um efeito bactericida, com as mais altas concentrações usadas as quais corresponderam em média a 6 vêzes as concentrações bacteriostáticas para esse gênero.

  2. Investigation into stress wave propagation in metal foams

    Directory of Open Access Journals (Sweden)

    Li Lang

    2015-01-01

    Full Text Available The aim of this study is to investigate stress wave propagation in metal foams under high-speed impact loading. Three-dimensional Voronoi model is established to represent real closed-cell foam. Based on the one-dimensional stress wave theory and Voronoi model, a numerical model is developed to calculate the velocity of elastic wave and shock wave in metal foam. The effects of impact velocity and relative density of metal foam on the stress wave propagation in metal foams are explored respectively. The results show that both elastic wave and shock wave propagate faster in metal foams with larger relative density; with increasing the impact velocity, the shock wave propagation velocity increase, but the elastic wave propagation is not sensitive to the impact velocity.

  3. Finite Amplitude Ocean Waves

    Indian Academy of Sciences (India)

    IAS Admin

    (2). Hence, small amplitude waves are also called linear waves. Most of the aspects of the ocean waves can be explained by the small amplitude wave theory. Let us now see the water particle motion due to waves. While wave energy is carried by the wave as it progresses forward, the water particles oscillate up and down.

  4. High frequency ion sound waves associated with Langmuir waves in type III radio burst source regions

    Directory of Open Access Journals (Sweden)

    G. Thejappa

    2004-01-01

    Full Text Available Short wavelength ion sound waves (2-4kHz are detected in association with the Langmuir waves (~15-30kHz in the source regions of several local type III radio bursts. They are most probably not due to any resonant wave-wave interactions such as the electrostatic decay instability because their wavelengths are much shorter than those of Langmuir waves. The Langmuir waves occur as coherent field structures with peak intensities exceeding the Langmuir collapse thresholds. Their scale sizes are of the order of the wavelength of an ion sound wave. These Langmuir wave field characteristics indicate that the observed short wavelength ion sound waves are most probably generated during the thermalization of the burnt-out cavitons left behind by the Langmuir collapse. Moreover, the peak intensities of the observed short wavelength ion sound waves are comparable to the expected intensities of those ion sound waves radiated by the burnt-out cavitons. However, the speeds of the electron beams derived from the frequency drift of type III radio bursts are too slow to satisfy the needed adiabatic ion approximation. Therefore, some non-linear process such as the induced scattering on thermal ions most probably pumps the beam excited Langmuir waves towards the lower wavenumbers, where the adiabatic ion approximation is justified.

  5. Speeding Up Innovation

    DEFF Research Database (Denmark)

    Sørensen, Flemming; Mattsson, Jan

    2016-01-01

    . Much innovation today takes place in open structures in which networks play an important role. However, little is known about how innovation networks can facilitate parallel innovation processes. This paper discusses how innovation network structures develop and support exploration and exploitation......Minimisation of time-to-market strategies can provide companies with a competitive advantage in dynamic and competitive environments. Using parallel innovation processes has been emphasised as one strategy to speed up innovation processes and consequently minimise the time-to-market of innovations...... in parallel innovation processes and in this way sustain speedy innovation processes. A case study of an innovation network is carried out by analysing communication structures and the information contents of emails related to a particular innovation process. The analysis shows how certain characteristics...

  6. HIGH SPEED CAMERA

    Science.gov (United States)

    Rogers, B.T. Jr.; Davis, W.C.

    1957-12-17

    This patent relates to high speed cameras having resolution times of less than one-tenth microseconds suitable for filming distinct sequences of a very fast event such as an explosion. This camera consists of a rotating mirror with reflecting surfaces on both sides, a narrow mirror acting as a slit in a focal plane shutter, various other mirror and lens systems as well as an innage recording surface. The combination of the rotating mirrors and the slit mirror causes discrete, narrow, separate pictures to fall upon the film plane, thereby forming a moving image increment of the photographed event. Placing a reflecting surface on each side of the rotating mirror cancels the image velocity that one side of the rotating mirror would impart, so as a camera having this short a resolution time is thereby possible.

  7. Shallow Water Waves and Solitary Waves

    OpenAIRE

    Hereman, Willy

    2013-01-01

    Encyclopedic article covering shallow water wave models used in oceanography and atmospheric science. Sections: Definition of the Subject; Introduction and Historical Perspective; Completely Integrable Shallow Water Wave Equations; Shallow Water Wave Equations of Geophysical Fluid Dynamics; Computation of Solitary Wave Solutions; Numerical Methods; Water Wave Experiments and Observations; Future Directions, and Bibliography.

  8. Wave groups in unidirectional surface wave models

    NARCIS (Netherlands)

    van Groesen, Embrecht W.C.

    1998-01-01

    Uni-directional wave models are used to study wave groups that appear in wave tanks of hydrodynamic laboratories; characteristic for waves in such tanks is that the wave length is rather small, comparable to the depth of the layer. In second-order theory, the resulting Nonlinear Schrödinger (NLS)

  9. Transforming growth factor-beta 1 downregulates dexamethasone-induced tetranectin gene expression during the in vitro mineralization of the human osteoblastic cell line SV-HFO

    DEFF Research Database (Denmark)

    Iba, K; Sawada, N; Chiba, H

    1995-01-01

    treatment as evidenced by Northern blotting. When transforming growth factor-beta 1 (TGF-beta 1) was added together with dexamethasone to the SV-HFO cell cultures, the mineralization process was markedly suppressed and the expression of tetra nectin and alkaline phosphatase was downregulated in a dose...

  10. Ambtscriminaliteit aangegeven? : Een onderzoek naar het opvolgen van en kennis over de wettelijke verplichting tot aangifte van artikel 162 Sv misdrijven

    NARCIS (Netherlands)

    Vries Robbé, E. de; Cornelissens, A.; Ferwerda, H.

    2008-01-01

    Dit is een onderzoek naar de werking van de aangifteplicht bij ambtscriminaliteit (art 162 Sv). Het gaat dan bijvoorbeeld om het aannemen van steekpenningen en misdrijven waarbij ambtenaren een bijzondere ambtsplicht schenden. De aangifteplicht raakt de klokkenluidersregeling en maakt onderdeel uit

  11. An Investigation of the Validity and Reliability of the Adapted Mathematics Anxiety Rating Scale-Short Version (MARS-SV) among Turkish Students

    Science.gov (United States)

    Baloglu, Mustafa

    2010-01-01

    This study adapted the Mathematics Anxiety Rating Scale-Short Version (MARS-SV) into Turkish and investigated the validity and reliability of the adapted instrument. Twenty-five bilingual experts agreed on the language validity, and 49 Turkish language experts agreed on the conformity and understandability of the scale's items. Thirty-two subject…

  12. Full wave simulations of fast wave mode conversion and lower hybrid wave propagation in tokamaks

    DEFF Research Database (Denmark)

    Wright, J.C.; Bonoli, P.T.; Brambilla, M.

    2004-01-01

    ). Two full wave codes, a massively-parallel-processor (MPP) version of the TORIC-2D finite Larmor radius code [M. Brambilla, Plasma Phys. Controlled Fusion 41, 1 (1999)] and also an all orders spectral code AORSA2D [E. F. Jaeger , Phys. Plasmas 9, 1873 (2002)], have been developed which for the first......Fast wave (FW) studies of mode conversion (MC) processes at the ion-ion hybrid layer in toroidal plasmas must capture the disparate scales of the FW and mode converted ion Bernstein and ion cyclotron waves. Correct modeling of the MC layer requires resolving wavelengths on the order of k...... time are capable of achieving the resolution and speed necessary to address mode conversion phenomena in full two-dimensional (2-D) toroidal geometry. These codes have been used in conjunction with theory and experimental data from the Alcator C-Mod [I. H. Hutchinson , Phys. Plasmas 1, 1511 (1994...

  13. Wave Dragon

    DEFF Research Database (Denmark)

    Kramer, Morten; Frigaard, Peter

    På foranledning af Löwenmark F.R.I, er der udført numeriske beregninger af Wave Dragons (herefter WD) armes effektivitet for forskellige geometriske udformninger. 5 geometriske modeller, hvor WD's arme er forkortet/forlænget er undersøgt for 3 forskellige drejninger af armene. I alt er 15...

  14. INTERFERENCE OF COUNTERPROPAGATING SHOCK WAVES

    Directory of Open Access Journals (Sweden)

    P. V. Bulat

    2015-03-01

    Full Text Available The subject of study. We examined the interaction of counterpropagating shock waves. The necessity of counterpropagating shock waves studying occurs at designing of high Mach number modern internal compression air intakes, Ramjets with subsonic and supersonic combustion, in asymmetrical supersonic nozzles and in some other cases. In a sense, this problem is a generalization of the case of an oblique shock reflection from the wall or from the plane of symmetry. With the renewed vigor, the interest to this problem emerged at the end of the 90s. This was due to the start of the programs for flight study at hypersonic speeds. The first experiments performed with air intakes, which realized the interaction of counterpropagating shock waves have shown that the change in flow velocity is accompanied by abrupt alteration of shock-wave structure, the occurrence of nonstationary and oscillatory phenomena. With an increase of flow velocity these phenomena undesirable for aircraft structure became more marked. The reason is that there are two fundamentally different modes of interaction of counterpropagating shock waves: a four-wave regular and a five-wave irregular. The transition from one mode to another can be nonstationary abrupt or gradual, it can also be accompanied by hysteresis. Main results. Criteria for the transition from regular reflection of counterpropagating shock waves to irregular are described: the criterion of von Neumann and the stationary Mach configuration criterion. We described areas in which the transition from one reflection type to another is possible only in abrupt way, as well as areas of possible gradual transition. Intensity dependences of the reflected shock waves from the intensity of interacting counterpropagating shocks were given. Qualitative pictures of shock-wave structures arising from the interaction of counterpropagating shock waves were shown. Calculation results of the intensity of outgoing gas

  15. Evaluation of the Reference Numerical Parameters of the Monthly Method in ISO 13790 Considering S/V Ratio

    Directory of Open Access Journals (Sweden)

    Hee-Jeong Kwak

    2015-01-01

    Full Text Available Many studies have investigated the accuracy of the numerical parameters in the application of the quasi steady-state calculation method. The aim of this study is to derive the reference numerical parameters of the ISO 13790 monthly method by reflecting the surface-to-volume (S/V ratio and the characteristics of the structures. The calculation process was established, and the parameters necessary to derive the reference numerical parameters were calculated based on the input data prepared for the established calculation processes. The reference numerical parameters were then derived through regression analyses of the calculated parameters and the time constant. The parameters obtained from an apartment building and the parameters of the international standard were both applied to the Passive House Planning Package (PHPP and EnergyPlus programs, and the results were analyzed in order to evaluate the validity of the results. The analysis revealed that the calculation results based on the parameters derived from this study yielded lower error rates than those based on the default parameters in ISO 13790. However, the differences were shown to be negligible in the case of high heat capacity.

  16. [Effects of histone deacetylase inhibitor sodium valproate on the physical and behavioral development of 129SV mice].

    Science.gov (United States)

    Burenkova, O V; Aleksandrova, E A; Zarayskaya, I Yu

    2015-01-01

    Sodium valproate is a widely used antiepileptic drug at high dosage levels, but it has been shown to produce a variety of toxic side-effects when used during perinatal period. These effects include increased risk of congenital anomalies and autism. For this reason, valproate is commonly employed in animal model of autism. Sodium valproate has multiple molecular targets including histone deacetylases. Therefore valproate can be utilized as a tool for the modulation of epigenetic modifications of the genome via inhibition of histone deacetylases. It is known that administration of sodium valproate at a dose of 50 mg/kg during early postnatal period leads to increase of the histone H3 acetylation level in the brain. The aim of the present study was to evaluate the effects of multiple valproate injections from 3rd to 6th postnatal day (50 mg/kg s.c.) on physical and sensorimotor development of 129Sv mice. The standard battery of tests was used. Our results show that valproate have no negative effect on physical development, sensorimotor function, and social behavior. The obtained results support the applicability of sodium valproate in our dosing schedule for further experimental modulation of histone acetulation level in the developing brain.

  17. Spectral variability of /s/ in sV and sCV sequences produced by adults and children

    Science.gov (United States)

    Munson, Benjamin

    2002-05-01

    Previous research has demonstrated that both children and adults produce /s/ with greater spectral variability in /sp/ sequences than /st/ sequences, when these sequences are embedded in the medial position of CVCCVC nonwords [B. Munson, J. Acoust. Soc. Am. 110, 1203-1206 (2001)]. The current study examined whether this result could be replicated when /s/ is embedded in syllable-onset clusters, with a variety of following consonants and vowels. Adults and children aged 3-7 were recorded producing multiple tokens of sV and sCV nonwords, where the vowel was either /i/, /opena/, or /u/, and the consonant was either /p/, /t/, /w/, or /l/. For each token, the spectral mean of non-overlapping 10-ms windows of frication noise was calculated. Nonlinear regressions of the form y=aebx were used to predict the spectral mean of each portion of frication noise from its position in the fricative. The resulting measure of model fit, R2, was used as an index of within-speaker variability. For each participant, separate R2 values were calculated for /s/ in each of the 15 phonetic contexts. Analyses will address the influence of age, consonant context, and vowel context on spectral variability.

  18. Immortalization of Porcine 11β-Hydroxysteroid Dehydrogenase Type 1-Transgenic Liver Cells Using SV40 Large T Antigen

    Directory of Open Access Journals (Sweden)

    Hee Young Kang

    2017-12-01

    Full Text Available Cortisol is a steroid hormone essential to the maintenance of homeostasis that is released in response to stress and low blood glucose concentration. Cortisol is converted from cortisone by 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1. It has been reported that too much cortisol or overexpression of HSD11B1 induces obesity and the insulin resistance that accompanies metabolic syndrome in rodent adipose tissue. In our previous study, HSD11B1-transgenic (TG fibroblasts were established, and a porcine model was generated by SCNT using those fibroblasts. Hepatocytes overexpressing HSD11B1 were obtained from livers of this porcine model and cultured in vitro. However, the primary hepatocytes were found to have a short life span or low proliferation rate. To overcome these problems, the SV40 large T antigen was transduced into primary HSD11B1-TG hepatocytes, and those cells were immortalized. Immortalized HSD11B1-TG hepatocytes showed restored morphology, more rapid proliferation rate, and more expression of HSD11B1 than primary hepatocytes. As well, these cells kept the hepatic characteristics such as gluconeogenic response to cortisone and increased expression of hepatic makers. The immortalized HSD11B1-TG hepatocytes may be useful for studying traits and potential therapeutic drugs for treatment of metabolic disorders induced by overexpression of HSD11B1.

  19. Immortalization of Porcine 11β-Hydroxysteroid Dehydrogenase Type 1-Transgenic Liver Cells Using SV40 Large T Antigen.

    Science.gov (United States)

    Kang, Hee Young; Choi, Young-Kwon; Jeong, Yeon Ik; Choi, Kyung-Chul; Hyun, Sang-Hwan; Hwang, Woo-Suk; Jeung, Eui-Bae

    2017-12-05

    Cortisol is a steroid hormone essential to the maintenance of homeostasis that is released in response to stress and low blood glucose concentration. Cortisol is converted from cortisone by 11βhydroxysteroid dehydrogenase type 1 (HSD11B1). It has been reported that too much cortisol or overexpression of HSD11B1 induces obesity and the insulin resistance that accompanies metabolic syndrome in rodent adipose tissue. In our previous study, HSD11B1-transgenic (TG) fibroblasts were established, and a porcine model was generated by SCNT using those fibroblasts. Hepatocytes overexpressing HSD11B1 were obtained from livers of this porcine model and cultured in vitro. However, the primary hepatocytes were found to have a short life span or low proliferation rate. To overcome these problems, the SV40 large T antigen was transduced into primary HSD11B1-TG hepatocytes, and those cells were immortalized. Immortalized HSD11B1-TG hepatocytes showed restored morphology, more rapid proliferation rate, and more expression of HSD11B1 than primary hepatocytes. As well, these cells kept the hepatic characteristics such as gluconeogenic response to cortisone and increased expression of hepatic makers. The immortalized HSD11B1-TG hepatocytes may be useful for studying traits and potential therapeutic drugs for treatment of metabolic disorders induced by overexpression of HSD11B1.

  20. StralSV: assessment of sequence variability within similar 3D structures and application to polio RNA-dependent RNA polymerase

    Energy Technology Data Exchange (ETDEWEB)

    Zemla, A; Lang, D; Kostova, T; Andino, R; Zhou, C

    2010-11-29

    Most of the currently used methods for protein function prediction rely on sequence-based comparisons between a query protein and those for which a functional annotation is provided. A serious limitation of sequence similarity-based approaches for identifying residue conservation among proteins is the low confidence in assigning residue-residue correspondences among proteins when the level of sequence identity between the compared proteins is poor. Multiple sequence alignment methods are more satisfactory - still, they cannot provide reliable results at low levels of sequence identity. Our goal in the current work was to develop an algorithm that could overcome these difficulties and facilitate the identification of structurally (and possibly functionally) relevant residue-residue correspondences between compared protein structures. Here we present StralSV, a new algorithm for detecting closely related structure fragments and quantifying residue frequency from tight local structure alignments. We apply StralSV in a study of the RNA-dependent RNA polymerase of poliovirus and demonstrate that the algorithm can be used to determine regions of the protein that are relatively unique or that shared structural similarity with structures that are distantly related. By quantifying residue frequencies among many residue-residue pairs extracted from local alignments, one can infer potential structural or functional importance of specific residues that are determined to be highly conserved or that deviate from a consensus. We further demonstrate that considerable detailed structural and phylogenetic information can be derived from StralSV analyses. StralSV is a new structure-based algorithm for identifying and aligning structure fragments that have similarity to a reference protein. StralSV analysis can be used to quantify residue-residue correspondences and identify residues that may be of particular structural or functional importance, as well as unusual or unexpected

  1. The Prognostic Role and Relationship between E2F1 and SV40 in Diffuse Large B-Cell Lymphoma of Egyptian Patients

    Directory of Open Access Journals (Sweden)

    Rehab M. Samaka

    2015-01-01

    Full Text Available Diffuse large B-cell lymphoma (DLBCL is the most common type of lymphomas worldwide. The pathogenesis of lymphomas is not yet well understood. SV40 induces malignant transformation by the large T-antigen (L-TAG and promotes transformation by binding and inactivating p53 and pRb. L-TAG can bind pRb promoting the activation of the E2F1 transcription factor, thus inducing the expression of genes required for the entry to the S phase and leading to cell transformation. This immunohistochemical study was conducted to assess the prognostic role and relationship of SV40 L-TAG and E2F1 in diffuse large B-cell lymphoma (DLBCL of Egyptian patients. This retrospective study was conducted on 105 tissue specimens including 20 follicular hyperplasia and 85 DLBCL cases. SV40 L-TAG was identified in 3/85 (4% of DLBCL. High Ki-67 labeling index (Ki-67 LI and apoptotic count were associated with high E2F1 expression (p<0.001 for all. No significant association was reached between E2F1 and SV40. E2F1 expression proved to be the most and first independent prognostic factor on overall survival of DLBCL patients (HR = 5.79, 95% CI = 2.3–14.6, and p<0.001. Upregulation of E2F1 has been implicated in oncogenesis, prognosis, and prediction of therapeutic response but is not seemingly to have a relationship with the accused SV40.

  2. Differences in memory development among C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl mice after delay and trace fear conditioning.

    Science.gov (United States)

    March, Amelia; Borchelt, David; Golde, Todd; Janus, Christopher

    2014-02-01

    Fear-conditioning testing paradigms have been used to study differences in memory formation between inbred mouse strains, including numerous mouse models of human diseases. In this study, we characterized the conditioned fear memory of 3 inbred strains: C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl, obtained from Charles River Laboratories. We used 2 training paradigms: delay conditioning, in which an unconditional stimulus coterminates with the presentation of a conditional stimulus, and trace conditioning, in which the conditional and unconditional stimuli are separated by a trace interval. In each paradigm, we evaluated the recent (3 d) and remote (25 d) memory of the mice by using a longitudinal design. Our results showed that both C57BL/6NCrl and 129S2/SvPasCrl mice developed strong and long-lasting context and tone memories in both paradigms, but FVB/NCrl mice showed a weaker but nevertheless consistent tone memory after delay training. Tone memory in the FVB strain was stronger in male than female mice. The remote tone memory of 129S2/SvPasCrl mice diminished after delay training but was stable and stronger than that of C57BL/6NCrl mice after trace training. In conclusion, both C57BL/6NCrl and 129S2/SvPasCrl mice showed reliable and long-lasting fear memory after delay or trace training, with 129 mice showing particularly strong tone memory after trace conditioning. The FVB/NCrl strain, especially male mice, showed reliable tone fear memory after delay training. Our findings confirm that both C57BL/6NCrl and 129S2/SvPasCrl mice develop strong context and tone memory in delay and trace fear-conditioning paradigms.

  3. Faraday wave lattice as an elastic metamaterial

    CERN Document Server

    Domino, L; Patinet, Sylvain; Eddi, A

    2016-01-01

    Metamaterials enable the emergence of novel physical properties due to the existence of an underlying sub-wavelength structure. Here, we use the Faraday instability to shape the fluid-air interface with a regular pattern. This pattern undergoes an oscillating secondary instability and exhibits spontaneous vibrations that are analogous to transverse elastic waves. By locally forcing these waves, we fully characterize their dispersion relation and show that a Faraday pattern presents an effective shear elasticity. We propose a physical mechanism combining surface tension with the Faraday structured interface that quantitatively predicts the elastic wave phase speed, revealing that the liquid interface behaves as an elastic metamaterial.

  4. Faraday wave lattice as an elastic metamaterial.

    Science.gov (United States)

    Domino, L; Tarpin, M; Patinet, S; Eddi, A

    2016-05-01

    Metamaterials enable the emergence of novel physical properties due to the existence of an underlying subwavelength structure. Here, we use the Faraday instability to shape the fluid-air interface with a regular pattern. This pattern undergoes an oscillating secondary instability and exhibits spontaneous vibrations that are analogous to transverse elastic waves. By locally forcing these waves, we fully characterize their dispersion relation and show that a Faraday pattern presents an effective shear elasticity. We propose a physical mechanism combining surface tension with the Faraday structured interface that quantitatively predicts the elastic wave phase speed, revealing that the liquid interface behaves as an elastic metamaterial.

  5. Twin motion faster than the speed of sound.

    Science.gov (United States)

    Faran, Eilon; Shilo, Doron

    2010-04-16

    Twin growth is commonly thought to be bounded by the velocity of shear waves C(T) at which the information about this mechanical process travels in the material. Here, we report on experimental evidence of twin growth faster than the material's speed of sound. Driven by an electric field, needle twins in a ferroelectric crystal grew at intersonic speed, with an estimated average velocity close to square root(2) C(T). These results strengthen recent theoretical indications of intersonic dislocation motion, and contribute to the understanding of several twin motion-related processes.

  6. An Experimental Investigation of the Wave Pattern Generated by a Moving Pressure Source: Solitary Capillary-Gravity Waves

    Science.gov (United States)

    Duncan, J. H.; Diorio, J. D.; Lisiewski, A.; Harris, R.

    2009-11-01

    The wave pattern generated by a small pressure source moving across a water surface at speeds less than the minimum phase speed for linear gravity-capillary waves (cmin = 23 cm/s) was investigated experimentally. The resulting wave pattern was measured using cinematic shadowgraph and laser-induced fluorescence (LIF) techniques. The results show the existence of several distinct behavioral states. At low speeds, no wave behavior is observed and the pattern resembles the symmetric stationary condition. However, at a critical speed, but still below cmin, the pattern undergoes a sudden transition to an asymmetric state with a stationary, 2D solitary wave that forms behind the pressure source. This solitary wave is elongated in the cross-stream relative to the stream-wise direction and resembles gravity-capillary ``lumps'' observed in previous numerical calculations. As the translation speed approaches cmin, another time-dependent behavior is observed characterized by periodic ``shedding'' from a V-shaped solitary wave pattern. This work will be discussed in conjunction with the recent numerical calculations of T. Akylas and his research group.

  7. SvSXP

    DEFF Research Database (Denmark)

    Andersen, Ulla Vestergaard; Howe, Daniel K.; Dangoudoubiyam, Sriveny

    2013-01-01

    Strongyle parasites are ubiquitous in grazing horses. Strongylus vulgaris, the most pathogenic of the large strongyles, is known for its extensive migration in the mesenteric arterial system. The lifecycle of S. vulgaris is characterised by a long prepatent period where the migrating larvae...... are virtually undetectable as there currently is no test available for diagnosing prepatent S. vulgaris infection. Presence of S. vulgaris larvae in the arterial system causes endarteritis and thrombosis with a risk of non-strangulating intestinal infarctions. Emergence of anthelmintic resistance among...

  8. SV-AUTOPILOT

    NARCIS (Netherlands)

    Leung, Wai Yi; Marschall, Tobias; Paudel, Yogesh; Falquet, Laurent; Mei, Hailiang; Schönhuth, Alexander; Maoz Moss, Tiffanie Yael

    2015-01-01

    Background: Many tools exist to predict structural variants (SVs), utilizing a variety of algorithms. However, they have largely been developed and tested on human germline or somatic (e.g. cancer) variation. It seems appropriate to exploit this wealth of technology available for humans also for

  9. SV Ganesan Srinivasan Natarajan

    Indian Academy of Sciences (India)

    The anions consist of a ring of five MoO6 distorted octahedra with four edge connections and one corner connection. The phosphate groups cap the pentamolybdate ring anion on either side. The anion is stabilized by strong hydrogen bonds involving the hydrogen atoms of the amine molecules and the oxygen atoms of the ...

  10. Traveling waves in a spring-block chain sliding down a slope

    Science.gov (United States)

    Morales, J. E.; James, G.; Tonnelier, A.

    2017-07-01

    Traveling waves are studied in a spring slider-block model. We explicitly construct front waves (kinks) for a piecewise-linear spinodal friction force. Pulse waves are obtained as the matching of two traveling fronts with identical speeds. Explicit formulas are obtained for the wavespeed and the wave form in the anticontinuum limit. The link with localized waves in a Burridge-Knopoff model of an earthquake fault is briefly discussed.

  11. Numerical modelling of the extreme wave climate in the Belgian harbours: part 3. Marina of Blankenberge

    OpenAIRE

    Suzuki, T; Gruwez, V.; A. Bolle; Verwaest, T.; Mostaert, F

    2012-01-01

    The design of water and wave retaining walls and flood risk analyses need hydrodynamic boundary conditions. These boundary conditions are needed during a storm with return period 1000yrs and during the super storms which were defined in the risk analysis study. The modelling of the extreme wave climate is decoupled to the wave penetration and the lacal generation of waves by the extreme wind speed. The wave penetration is modelled with Mike 21 BW as was done for Oostende and Zeebrugge. MILDwa...

  12. Damping Wind and Wave Loads on a Floating Wind Turbine

    DEFF Research Database (Denmark)

    Christiansen, Søren; Bak, Thomas; Knudsen, Torben

    2013-01-01

    and tower side-side motion, including gyroscopic effects. The models support a model-based design that includes estimators for wind speed and wave frequency. The design is applied to a number of examples representing different wind and wave conditions and successfully demonstrates a reduction...

  13. Surface Gravity Waves: Resonance in a Fish Tank

    Science.gov (United States)

    Sinick, Scott J.; Lynch, John J.

    2010-01-01

    In this work, an inexpensive 10-gallon glass aquarium was used to study wave motion in water. The waves travel at speeds comparable to a person walking ([approximately]1 m/s). The scale of the motion allows for distances to be measured with a meterstick and for times to be measured with a stopwatch. For a wide range of water depths, standing waves…

  14. High-speed AC motors

    Energy Technology Data Exchange (ETDEWEB)

    Jokinen, T.; Arkkio, A. [Helsinki University of Technology Laboratory of Electromechanics, Otaniemi (Finland)

    1997-12-31

    The paper deals with various types of highspeed electric motors, and their limiting powers. Standard machines with laminated rotors can be utilised if the speed is moderate. The solid rotor construction makes it possible to reach higher power and speed levels than those of laminated rotors. The development work on high-speed motors done at Helsinki University of Technology is presented, too. (orig.) 12 refs.

  15. Human cortical traveling waves: dynamical properties and correlations with responses.

    Directory of Open Access Journals (Sweden)

    Timothy M Patten

    Full Text Available The spatiotemporal behavior of human EEG oscillations is investigated. Traveling waves in the alpha and theta ranges are found to be common in both prestimulus and poststimulus EEG activity. The dynamical properties of these waves, including their speeds, directions, and durations, are systematically characterized for the first time, and the results show that there are significant changes of prestimulus spontaneous waves in the presence of an external stimulus. Furthermore, the functional relevance of these waves is examined by studying how they are correlated with reaction times on a single trial basis; prestimulus alpha waves traveling in the frontal-to-occipital direction are found to be most correlated to reaction speeds. These findings suggest that propagating waves of brain oscillations might be involved in mediating long-range interactions between widely distributed parts of human cortex.

  16. Diffractons: Solitary Waves Created by Diffraction in Periodic Media

    KAUST Repository

    Ketcheson, David I.

    2015-03-31

    A new class of solitary waves arises in the solution of nonlinear wave equations with constant impedance and no dispersive terms. These solitary waves depend on a balance between nonlinearity and a dispersion-like effect due to spatial variation in the sound speed of the medium. A high-order homogenized model confirms this effective dispersive behavior, and its solutions agree well with those obtained by direct simulation of the variable-coefficient system. These waves are observed to be long-time stable, globally attracting solutions that arise in general as solutions to nonlinear wave problems with periodically varying sound speed. They share some properties with known classes of solitary waves but possess important differences as well.

  17. Wind speed perception and risk.

    Directory of Open Access Journals (Sweden)

    Duzgun Agdas

    Full Text Available BACKGROUND: How accurately do people perceive extreme wind speeds and how does that perception affect the perceived risk? Prior research on human-wind interaction has focused on comfort levels in urban settings or knock-down thresholds. No systematic experimental research has attempted to assess people's ability to estimate extreme wind speeds and perceptions of their associated risks. METHOD: We exposed 76 people to 10, 20, 30, 40, 50, and 60 mph (4.5, 8.9, 13.4, 17.9, 22.3, and 26.8 m/s winds in randomized orders and asked them to estimate wind speed and the corresponding risk they felt. RESULTS: Multilevel modeling showed that people were accurate at lower wind speeds but overestimated wind speeds at higher levels. Wind speed perceptions mediated the direct relationship between actual wind speeds and perceptions of risk (i.e., the greater the perceived wind speed, the greater the perceived risk. The number of tropical cyclones people had experienced moderated the strength of the actual-perceived wind speed relationship; consequently, mediation was stronger for people who had experienced fewer storms. CONCLUSION: These findings provide a clearer understanding of wind and risk perception, which can aid development of public policy solutions toward communicating the severity and risks associated with natural disasters.

  18. Wind Speed Perception and Risk

    Science.gov (United States)

    Agdas, Duzgun; Webster, Gregory D.; Masters, Forrest J.

    2012-01-01

    Background How accurately do people perceive extreme wind speeds and how does that perception affect the perceived risk? Prior research on human–wind interaction has focused on comfort levels in urban settings or knock-down thresholds. No systematic experimental research has attempted to assess people's ability to estimate extreme wind speeds and perceptions of their associated risks. Method We exposed 76 people to 10, 20, 30, 40, 50, and 60 mph (4.5, 8.9, 13.4, 17.9, 22.3, and 26.8 m/s) winds in randomized orders and asked them to estimate wind speed and the corresponding risk they felt. Results Multilevel modeling showed that people were accurate at lower wind speeds but overestimated wind speeds at higher levels. Wind speed perceptions mediated the direct relationship between actual wind speeds and perceptions of risk (i.e., the greater the perceived wind speed, the greater the perceived risk). The number of tropical cyclones people had experienced moderated the strength of the actual–perceived wind speed relationship; consequently, mediation was stronger for people who had experienced fewer storms. Conclusion These findings provide a clearer understanding of wind and risk perception, which can aid development of public policy solutions toward communicating the severity and risks associated with natural disasters. PMID:23226230

  19. Wave propagation in thermoelastic saturated porous medium

    Indian Academy of Sciences (India)

    playing a crucial role in non-destructive evaluation. (NDE) of composite materials and structures. The studies of ... diffusion type heat equation used in this study predicted infinite speed for propagation of ther- mal signals. ..... the NDE problems involving wave propagation in thermoelastic porous solids. When supported with.

  20. Wind and waves in extreme hurricanes

    NARCIS (Netherlands)

    Holthuijsen, L.H.; Powell, M.D.; Pietrzak, J.D.

    2012-01-01

    Waves breaking at the ocean surface are important to the dynamical, chemical and biological processes at the air-sea interface. The traditional view is that the white capping and aero-dynamical surface roughness increase with wind speed up to a limiting value. This view is fundamental to hurricane

  1. Extreme Loads on the Mooring Lines and Survivability Mode for the Wave Dragon Wave Energy Converter

    DEFF Research Database (Denmark)

    Parmeggiani, Stefano; Kofoed, Jens Peter; Friis-Madsen, E.

    2011-01-01

    One of the main challenges Wave Energy Converters have to face on the road towards commercialization is to ensure survivability in extreme condition at a reasonable capital costs. For a floating device like the Wave Dragon, a reliable mooring system is essential. The control strategy of the Wave...... Dragon aims at optimizing the power production by adapting the floating level to the incoming waves and by activating the hydro-turbines and regulating their working speed. In extreme conditions though, the control strategy could be changed in order to reduce the forces in the mooring system, lowering...... the design requirements with almost no added cost. The paper presents the result of the tank testing of a 1:51.8 scale model of a North Sea Wave Dragon in extreme wave conditions of up to 100 years of return period. The results show that the extreme loads in the main mooring line can be reduced...

  2. Gravitational waves

    CERN Document Server

    Ciufolini, I; Moschella, U; Fre, P

    2001-01-01

    Gravitational waves (GWs) are a hot topic and promise to play a central role in astrophysics, cosmology, and theoretical physics. Technological developments have led us to the brink of their direct observation, which could become a reality in the coming years. The direct observation of GWs will open an entirely new field: GW astronomy. This is expected to bring a revolution in our knowledge of the universe by allowing the observation of previously unseen phenomena, such as the coalescence of compact objects (neutron stars and black holes), the fall of stars into supermassive black holes, stellar core collapses, big-bang relics, and the new and unexpected.With a wide range of contributions by leading scientists in the field, Gravitational Waves covers topics such as the basics of GWs, various advanced topics, GW detectors, astrophysics of GW sources, numerical applications, and several recent theoretical developments. The material is written at a level suitable for postgraduate students entering the field.

  3. Wave Star

    DEFF Research Database (Denmark)

    Kramer, Morten; Frigaard, Peter; Brorsen, Michael

    Nærværende rapport beskriver foreløbige hovedkonklusioner på modelforsøg udført på Aalborg Universitet, Institut for Vand, Jord og Miljøteknik med bølgeenergianlægget Wave Star i perioden 13/9 2004 til 12/11 2004.......Nærværende rapport beskriver foreløbige hovedkonklusioner på modelforsøg udført på Aalborg Universitet, Institut for Vand, Jord og Miljøteknik med bølgeenergianlægget Wave Star i perioden 13/9 2004 til 12/11 2004....

  4. Wave Propagation

    CERN Document Server

    Ferrarese, Giorgio

    2011-01-01

    Lectures: A. Jeffrey: Lectures on nonlinear wave propagation.- Y. Choquet-Bruhat: Ondes asymptotiques.- G. Boillat: Urti.- Seminars: D. Graffi: Sulla teoria dell'ottica non-lineare.- G. Grioli: Sulla propagazione del calore nei mezzi continui.- T. Manacorda: Onde nei solidi con vincoli interni.- T. Ruggeri: "Entropy principle" and main field for a non linear covariant system.- B. Straughan: Singular surfaces in dipolar materials and possible consequences for continuum mechanics

  5. Shock Waves

    CERN Document Server

    Jiang, Z

    2005-01-01

    The International Symposium on Shock Waves (ISSW) is a well established series of conferences held every two years in a different location. A unique feature of the ISSW is the emphasis on bridging the gap between physicists and engineers working in fields as different as gas dynamics, fluid mechanics and materials sciences. The main results presented at these meetings constitute valuable proceedings that offer anyone working in this field an authoritative and comprehensive source of reference.

  6. A novel method for direct localized sound speed measurement using the virtual source paradigm

    DEFF Research Database (Denmark)

    Byram, Brett; Trahey, Gregg E.; Jensen, Jørgen Arendt

    2007-01-01

    spatial locations. The method utilizes the sound speed estimator developed by Anderson and Trahey. Their least-squares fit of the received waveform's curvature provides the wave's point of origin. The point of origin and the delay profile calculated from the fit are used to arrive at a spatially...... registered virtual detector. Between a pair of registered virtual detectors a spherical wave is propagated. By beamforming the received data the time of flight between the two virtual sources can be calculated. From this information the local sound speed can be estimated. Validation of the estimator used......Accurate sound speed estimates are desirable in a number of fields, particularly adaptive imaging, and tissue and phantom characterization. In an effort to increase the spatial resolution of sound speed estimates, a new method is proposed for direct measurement of sound speed between arbitrary...

  7. Reflection and transmission of thermo-elastic waves without energy dissipation at the interface of two dipolar gradient elastic solids.

    Science.gov (United States)

    Li, Yueqiu; Wei, Peijun

    2018-01-01

    The reflection and transmission of thermal elastic waves at the interface between two different dipolar gradient elastic solids are studied based on the generalized thermo-elastic theory of Green and Naghdi [(1993). J. Elasticity 31, 189-208] (type II of no energy dissipation). First, some thermodynamic formulas are generalized to a dipolar gradient elastic solid and the function of free energy density is postulated. Second, equations of thermal motion and constitutive relations in a dipolar gradient elasticity are derived. Then the nontraditional interfacial conditions are used to determine the amplitude ratio of the reflection and transmission waves with respect to the incident wave. Some numerical results of the reflection and transmission coefficients in the form of an energy flux ratio are given for different microstructure parameters while thermal parameters are fixed. The numerical results are validated by the consideration of energy conservation. It is found that there are a total of five modes of dispersive waves, namely, coupled MT1 wave, coupled MT2 wave, coupled MT3 wave, SV wave, and one evanescent wave which reduces to the surface waves at an interface, namely, SS wave. The thermal parameters mainly affect the coupled MT2 wave while the microstructure parameters affect not only the coupled waves but also the SS surface waves.

  8. Universality of Sea Wave Growth and Its Physical Roots

    CERN Document Server

    Zakharov, Vladimir E; Hwang, Paul A; Caulliez, Guillemette

    2014-01-01

    Modern day studies of wind-driven sea waves are usually focused on wind forcing rather than on the effect of resonant nonlinear wave interactions. The authors assume that these effects are dominating and propose a simple relationship between instant wave steepness and time or fetch of wave development expressed in wave periods or lengths. This law does not contain wind speed explicitly and relies upon this asymptotic theory. The validity of this law is illustrated by results of numerical simulations, in situ measurements of growing wind seas and wind wave tank experiments. The impact of the new vision of sea wave physics is discussed in the context of conventional approaches to wave modeling and forecasting.

  9. Pharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjects.

    Science.gov (United States)

    Sargentini-Maier, Maria Laura; Espié, Pascal; Coquette, Alain; Stockis, Armel

    2008-01-01

    This study was designed to investigate the human absorption, disposition, and mass balance of (14)C-brivaracetam, a novel high affinity SV2A ligand with potent anticonvulsant activity. Six healthy male subjects received a single p.o. dose of (14)C-brivaracetam (150 mg, 82 microCi, or 3.03 MBq). Serial blood and complete urine and feces were collected until 144 h postdose. Expired air samples were obtained until 24 h. Brivaracetam was rapidly absorbed, with C(max) of 4 mug/ml occurring within 1.5 h of dosing. Unchanged brivaracetam amounted to 90% of the total plasma radioactivity, suggesting a modest first-pass effect. Plasma protein binding of radioactivity was low (17.5%). Urinary excretion exceeded 90% after 2 days, and the final mass balance reached 96.8% of the radioactivity in urine and 0.7% in feces. Only 8.6% of the radioactive dose was recovered in urine as unchanged brivaracetam, the remainder being identified as non-cytochrome P450 (P450)- and P450-dependent biotransformation products resulting from hydrolysis of the amide moiety (M9, 34.2%), hydroxylation of the n-propyl side chain (M1b, 15.9%), and a combination of these two pathways leading to the hydroxy acid (M4b, 15.2%). Minor amounts of taurine and glucuronic acid conjugates and other oxidized derivatives were also identified. Brivaracetam is completely absorbed, is weakly bound to plasma proteins, extensively biotransformed through several metabolic pathways, and eliminated renally.

  10. Proinflammatory Effect of High Glucose Concentrations on HMrSV5 Cells via the Autocrine Effect of HMGB1.

    Science.gov (United States)

    Chu, Yuening; Wang, Yi; Zheng, Zhihuang; Lin, Yuli; He, Rui; Liu, Jun; Yang, Xuguang

    2017-01-01

    Background: Peritoneal fibrosis, in which inflammation and apoptosis play crucial pathogenic roles, is a severe complication associated with the treatment of kidney failure with peritoneal dialysis (PD) using a glucose-based dialysate. Mesothelial cells (MCs) take part in the inflammatory processes by producing various cytokines and chemokines, such as monocyte chemoattractant protein 1 (MCP-1) and interleukin 8 (IL-8). The apoptosis of MCs induced by high glucose levels also contributes to complications of PD. High mobility group protein B1 (HMGB1) is an inflammatory factor that has repeatedly been proven to be related to the occurrence of peritoneal dysfunction. Aim: In this study, we aimed to explore the effect and underlying mechanism of endogenous HMGB1 in high-glucose-induced MC injury. Methods: The human peritoneal MC line, HMrSV5 was cultured in high-glucose medium and incubated with recombinant HMGB1. Cellular expression of HMGB1 was blocked using HMGB1 small interfering RNA (siRNA). Apoptosis and production of inflammatory factors as well as the potential intermediary signaling pathways were examined. Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways. In conclusion, endogenous HMGB1 plays an important role in the inflammatory reaction induced by high glucose on MCs via mitogen-activated protein kinase (MAPK) signaling pathways, but it seems to have little effect on high-glucose-induced apoptosis.

  11. Proinflammatory Effect of High Glucose Concentrations on HMrSV5 Cells via the Autocrine Effect of HMGB1

    Directory of Open Access Journals (Sweden)

    Yuening Chu

    2017-09-01

    Full Text Available Background: Peritoneal fibrosis, in which inflammation and apoptosis play crucial pathogenic roles, is a severe complication associated with the treatment of kidney failure with peritoneal dialysis (PD using a glucose-based dialysate. Mesothelial cells (MCs take part in the inflammatory processes by producing various cytokines and chemokines, such as monocyte chemoattractant protein 1 (MCP-1 and interleukin 8 (IL-8. The apoptosis of MCs induced by high glucose levels also contributes to complications of PD. High mobility group protein B1 (HMGB1 is an inflammatory factor that has repeatedly been proven to be related to the occurrence of peritoneal dysfunction.Aim: In this study, we aimed to explore the effect and underlying mechanism of endogenous HMGB1 in high-glucose-induced MC injury.Methods: The human peritoneal MC line, HMrSV5 was cultured in high-glucose medium and incubated with recombinant HMGB1. Cellular expression of HMGB1 was blocked using HMGB1 small interfering RNA (siRNA. Apoptosis and production of inflammatory factors as well as the potential intermediary signaling pathways were examined.Results: The major findings of these analyses were: (1 MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2 HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3 HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways. In conclusion, endogenous HMGB1 plays an important role in the inflammatory reaction induced by high glucose on MCs via mitogen-activated protein kinase (MAPK signaling pathways, but it seems to have little effect on high-glucose-induced apoptosis.

  12. Output filters for AC adjustable speed drives

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Hanigovszki, Norbert; Landkildehus, Jorn, Jorn

    2007-01-01

    The standard industrial solution for adjustable speed drives (ASD) is the use of induction motors (IM) fed by voltage-source inverters (VSI). The inverter generates a pulsewidth modulated (PWM) voltage, with dv/dt values of about 6 kV/¿s or even more. In three-leg inverters for three......-phase applications the occurrence of common-mode (CM) voltage is inherent due to asymmetrical output pulses [1]. Consequently, several secondary effects arise at the inverter's output: high-frequency conducted and radiated emissions, leakage current, motor insulation stress due to wave reflection [2], bearing stress...... due to bearing currents, acoustic switching noise. Depending on the specific application, the mitigation of some of these effects (or all) might be necessary. The common solution for mitigating the secondary effects at the output of PWM-VSI is the use of output filters [3],[5],[6]. Several types...

  13. Key features of wave energy.

    Science.gov (United States)

    Rainey, R C T

    2012-01-28

    For a weak point source or dipole, or a small body operating as either, we show that the power from a wave energy converter (WEC) is the product of the particle velocity in the waves, and the wave force (suitably defined). There is a thus a strong analogy with a wind or tidal turbine, where the power is the product of the fluid velocity through the turbine, and the force on it. As a first approximation, the cost of a structure is controlled by the force it has to carry, which governs its strength, and the distance it has to be carried, which governs its size. Thus, WECs are at a disadvantage compared with wind and tidal turbines because the fluid velocities are lower, and hence the forces are higher. On the other hand, the distances involved are lower. As with turbines, the implication is also that a WEC must make the most of its force-carrying ability-ideally, to carry its maximum force all the time, the '100% sweating WEC'. It must be able to limit the wave force on it in larger waves, ultimately becoming near-transparent to them in the survival condition-just like a turbine in extreme conditions, which can stop and feather its blades. A turbine of any force rating can achieve its maximum force in low wind speeds, if its diameter is sufficiently large. This is not possible with a simple monopole or dipole WEC, however, because of the 'nλ/2π' capture width limits. To achieve reasonable 'sweating' in typical wave climates, the force is limited to about 1 MN for a monopole device, or 2 MN for a dipole. The conclusion is that the future of wave energy is in devices that are not simple monopoles or dipoles, but multi-body devices or other shapes equivalent to arrays.

  14. Laboratory study of peculiarities of the freak-wave generation

    Science.gov (United States)

    Rodin, Artem; Tyugin, Dmitry; Kurkin, Andrey; Kurkina, Oxana; Didenkulova, Ira

    2017-04-01

    A new wave tank for wave measurements in experimental conditions is installed in the year of 2015 in the Nizhny Novgorod State Technical University n.a. R.E. Alekseev, which is now beginning to run. In recent study series of experiments were conducted in order to reproduce analytic solutions of approximate theories in the case of strong nonlinearity. In particular experimental work is aiming to test methods of extreme wave forecasting on the background of the irregular wave field. The statistics of rogue wave heights is studied together with the statistics of rogue wave crests and rogue wave troughs. The full length of the wave tank is 7 meters, which includes the size of the working area of 6.5 m and the rest occupies the hinged-type wavemaker. Width of the wave tank is 0.5 m and height is 1 m. The wavemaker has the amplitude in the range of 0-15 degrees and frequency in the range of 0.1 - 10 Hz. The wave tank set up contains also the basic instrumentation and video fixation system including a high-speed camera. The height of waves generated during strongly nonlinear regimes is comparable to the unperturbed depth of the water in the wave tank. In order to prevent the wave reflection from the walls laboratory facility is equipped with an effective removable louvered wave absorber, mounted on opposite end of the wave tank. Construction of wave absorber has adjustable height and tilt in order to select the most effective way of wave absorption. With this equipment conditions for different wave modes can be arranged: breaking waves, full absorbtion, as well as partial reflection that corresponds to different modes of wave field in the coastal zone. The research was supported within the framework of the Russian Science Foundation grant Nr 16-17-00041.

  15. Wind Speed and Sea State Dependencies of Air-Sea Gas Transfer: Results From the High Wind Speed Gas Exchange Study (HiWinGS)

    Science.gov (United States)

    Blomquist, B. W.; Brumer, S. E.; Fairall, C. W.; Huebert, B. J.; Zappa, C. J.; Brooks, I. M.; Yang, M.; Bariteau, L.; Prytherch, J.; Hare, J. E.; Czerski, H.; Matei, A.; Pascal, R. W.

    2017-10-01

    A variety of physical mechanisms are jointly responsible for facilitating air-sea gas transfer through turbulent processes at the atmosphere-ocean interface. The nature and relative importance of these mechanisms evolves with increasing wind speed. Theoretical and modeling approaches are advancing, but the limited quantity of observational data at high wind speeds hinders the assessment of these efforts. The HiWinGS project successfully measured gas transfer coefficients (k660) with coincident wave statistics under conditions with hourly mean wind speeds up to 24 m s-1 and significant wave heights to 8 m. Measurements of k660 for carbon dioxide (CO2) and dimethylsulfide (DMS) show an increasing trend with respect to 10 m neutral wind speed (U10N), following a power law relationship of the form: k660 CO2˜U10N1.68 and k660 dms˜U10N1.33. Among seven high wind speed events, CO2 transfer responded to the intensity of wave breaking, which depended on both wind speed and sea state in a complex manner, with k660 CO2 increasing as the wind sea approaches full development. A similar response is not observed for DMS. These results confirm the importance of breaking waves and bubble injection mechanisms in facilitating CO2 transfer. A modified version of the Coupled Ocean-Atmosphere Response Experiment Gas transfer algorithm (COAREG ver. 3.5), incorporating a sea state-dependent calculation of bubble-mediated transfer, successfully reproduces the mean trend in observed k660 with wind speed for both gases. Significant suppression of gas transfer by large waves was not observed during HiWinGS, in contrast to results from two prior field programs.

  16. Nonlinear Waves in the Terrestrial Quasiparallel Foreshock

    Science.gov (United States)

    Hnat, B.; Kolotkov, D. Y.; O'Connell, D.; Nakariakov, V. M.; Rowlands, G.

    2016-12-01

    We provide strongly conclusive evidence that the cubic nonlinearity plays an important part in the evolution of the large amplitude magnetic structures in the terrestrial foreshock. Large amplitude nonlinear wave trains at frequencies above the proton cyclotron frequency are identified after nonharmonic slow variations are filtered out by applying the empirical mode decomposition. Numerical solutions of the derivative nonlinear Schrödinger equation, predicted analytically by the use of a pseudopotential approach, are found to be consistent with the observed wave forms. The approximate phase speed of these nonlinear waves, indicated by the parameters of numerical solutions, is of the order of the local Alfvén speed. We suggest that the feedback of the large amplitude fluctuations on background plasma is reflected in the evolution of the pseudopotential.

  17. Underwater expansion wave focusing by reflecting at the air interface

    Science.gov (United States)

    Ohtani, K.; Ogawa, T.

    2017-02-01

    This paper reports a preliminarily experimental result of high-speed shadowgraph optical visualization of underwater expansion wave focusing by using a simple two-dimensional wedge model for understanding of shock wave interaction phenomena in simulated biomedical materials. Underwater shock wave generated by detonating a micro-explosive (10 mg silver azide pellet) in a small chamber. The generated underwater shock wave was interacted with a wedge shaped interface between water and air divided by a thin film, and an expansion wave was generated by reflection at the interface. The process of underwater expansion wave generation and focusing phenomena was visualized by shadowgraph method and recorded by ultra-high-speed framing camera. Underwater shock wave was reflected as an expansion wave from the interface between water and air at the both side and focused and then cavitation bubble was created by pressure decreasing at the expansion wave focusing area. The pressure histories were measured simultaneously with high-speed optical visualization by a needle type pressure sensor. At the focusing area, the pressure was decreased rapidly, the negative peak pressure was the lowest.

  18. Investigation on the propagation process of rotating detonation wave

    Science.gov (United States)

    Deng, Li; Ma, Hu; Xu, Can; Zhou, Changsheng; Liu, Xiao

    2017-10-01

    Effects of mass flow rate and equivalence ratio on the wave speed performance and instantaneous pressure characteristics of rotating detonation wave are investigated using hydrogen and air mixtures. The interaction between air and fuel manifolds and combustion chamber is also identified. The results show that the rotating detonation waves are able to adapt themselves to the changes of equivalence ratio during the run, the rotating detonation waves decayed gradually and then quenched after the shutdown of reactants supply. The wave speed performance is closely related to the mass flow rate and the pressure ratio of the fuel to air manifolds at different equivalence ratios. The blockage ratio of the air manifold increases with the increasing of the wave speed due to high-pressure detonation products, while increasing of the equivalence ratios will reduce the blockage ratio of the hydrogen manifold. Higher equivalence ratio can enhance the stabilization of the rotating detonation wave and lower equivalence ratio will lead to the large fluctuations of the lap time and instantaneous pressure magnitude. The overpressure of rotating detonation wave is determined by the combination of mass flow rate and equivalence ratio, which increases with the increasing of mass flow rate in the equivalence ratio ranges that the rotating detonation wave propagates stably. The secondary spike in the instantaneous pressure and ionization signals indicates that a shocked mixing zone exists near the fuel injection holes and the reflection of shock in the mixing zone induces the reaction.

  19. High Speed Viterbi Decoder Architecture

    DEFF Research Database (Denmark)

    Paaske, Erik; Andersen, Jakob Dahl

    1998-01-01

    The fastest commercially available Viterbi decoders for the (171,133) standard rate 1/2 code operate with a decoding speed of 40-50 Mbit/s (net data rate). In this paper we present a suitable architecture for decoders operating with decoding speeds of 150-300 Mbit/s....

  20. Optimal Speed Control for Cruising

    DEFF Research Database (Denmark)

    Blanke, M.

    1994-01-01

    With small profit margins in merchant shipping and more than eighty percent of sailing time being cross ocean voyages, speed control is crucial for vessel profitability......With small profit margins in merchant shipping and more than eighty percent of sailing time being cross ocean voyages, speed control is crucial for vessel profitability...

  1. Propagation and dispersion of shock waves in magnetoelastic materials

    Science.gov (United States)

    Crum, R. S.; Domann, J. P.; Carman, G. P.; Gupta, V.

    2017-12-01

    Previous studies examining the response of magnetoelastic materials to shock waves have predominantly focused on applications involving pulsed power generation, with limited attention given to the actual wave propagation characteristics. This study provides detailed magnetic and mechanical measurements of magnetoelastic shock wave propagation and dispersion. Laser generated rarefacted shock waves exceeding 3 GPa with rise times of 10 ns were introduced to samples of the magnetoelastic material Galfenol. The resulting mechanical measurements reveal the evolution of the shock into a compressive acoustic front with lateral release waves. Importantly, the wave continues to disperse even after it has decayed into an acoustic wave, due in large part to magnetoelastic coupling. The magnetic data reveal predominantly shear wave mediated magnetoelastic coupling, and were also used to noninvasively measure the wave speed. The external magnetic field controlled a 30% increase in wave propagation speed, attributed to a 70% increase in average stiffness. Finally, magnetic signals propagating along the sample over 20× faster than the mechanical wave were measured, indicating these materials can act as passive antennas that transmit information in response to mechanical stimuli.

  2. REFLECTION OF ELECTROMAGNETIC WAVES FROM SOUND WAVES

    Science.gov (United States)

    The reflection of electromagnetic waves normally incident on the wavefronts of a semi-infinite standing sound wave is discussed. By analogy with the...with the sound frequency. An experiment is described in which the Bragg reflection of 3 cm electromagnetic waves from a standing sound wave beneath a water surface is observed.

  3. Impact of Wave Dragon on Wave Climate

    DEFF Research Database (Denmark)

    Andersen, Thomas Lykke; Tedd, James; Kramer, Morten

    This report is an advisory paper for use in determining the wave dragon effects on hydrography, by considering the effect on the wave climate in the region of a wave dragon. This is to be used in the impact assessment for the Wave Dragon pre-commercial demonstrator....

  4. Deconvolution of teleseismicp-waves using the SVA and autoregressive techniques

    Science.gov (United States)

    Dasgupta, Saptarshi

    In this study, the deconvolution of three-component teleseismic P-waves is investigated using the autocorrelation of the P to SV scattered waves. By assuming that the P to SV scattering coefficients are random and white, the autocorrelation of the SV component (SVA) provides an estimate of the autocorrelation of the source and distant earth signature. This is similar to using the autocorrelation of a reflection seismogram for deconvolution in exploration seismology where the P to P scattering coefficients are assumed to be random and white. For earthquake data the source signature is generally not minimum phase. However a minimum phase wavelet obtained from the SV autocorrelation can be used to deconvolve the original data that have been processed to be minimum phase. The SVA approach has been tested using synthetic data and then applied to observed teleseismic data from the 1993 Cascadia experiment. Since deconvolution results are often restricted in frequency range, an extrapolation of the deconvolved frequency spectra is next investigated using an autoregressive (AR) approach and an extended time-domain deconvolution approach to obtain better temporal resolution. A prediction error filter is used to perform the autoregressive extrapolation to estimate the unknown spectral values of the deconvolution results. An extended time-domain deconvolution approach is also developed where the deconvolved spectra are enhanced using increased high-cut filters for the time-domain deconvolution. The AR and extended time-domain deconvolution approaches are compared using synthetic data and observed data from the GBA seismic array in India. The deconvolution of vertical component seismic data using the SVA technique is finally applied to selected INDEPTH II and CDSN seismic stations to investigate the P-wave velocity structure in southern Tibet. The deconvolved vertical component seismic data are inverted for P-velocity crustal structure and the resulting Moho depths at each

  5. Longitudinal and transverse modes of slosh wave excitation in rotating dewar associated with gravity jitters

    Science.gov (United States)

    Hung, R. J.; Lee, C. C.; Leslie, F. W.

    1991-01-01

    Characteristics of slosh waves based on the dynamical behavior of oscillations at the liquid-vapor interface have been investigated. Twelve case studies of slosh wave excitation due to various frequencies of gravity jitters under different rotating speeds of the propellant tank and different levels of background gravity environment have been simulated. The study shows that slosh waves excited inside the spacecraft propellant tank are characterized by the lowest frequency of the waves initiated, frequencies of the gravity jitters imposed on the propellant system, the levels of background gravity environment, and dewar rotating speeds. Conditions for suppression and amplification of the slosh waves are discussed.

  6. The deep structure of the Australian continent inferred from surface wave tomography

    NARCIS (Netherlands)

    Simons, Frederik J.; Zielhuis, A.; Hilst, R.D. van der

    1999-01-01

    We present a new model of 3-D variations of shear wave speed in the Australian upper mantle, obtained from the dispersion of fundamental and higher-mode surface waves. We used nearly 1600 Rayleigh wave data from the portable arrays of the SKIPPY project and from permanent stations (from AGSO, IRIS

  7. How to test gravitation theories by means of gravitational-wave measurements

    Science.gov (United States)

    Thorne, K. S.

    1974-01-01

    Gravitational-wave experiments are a potentially powerful tool for testing gravitation theories. Most theories in the literature predict rather different polarization properties for gravitational waves than are predicted by general relativity; and many theories predict anomalies in the propagation speeds of gravitational waves.

  8. Ultra-high-speed optical and electronic distributed devices

    Energy Technology Data Exchange (ETDEWEB)

    Hietala, V.M.; Plut, T.A.; Kravitz, S.H.; Vawter, G.A.; Wendt, J.R.; Armendariz, M.G.

    1995-08-01

    This report summarizes work on the development of ultra-high-speed semiconductor optical and electronic devices. High-speed operation is achieved by velocity matching the input stimulus to the output signal along the device`s length. Electronic devices such as field-effect transistors (FET`s), should experience significant speed increases by velocity matching the electrical input and output signals along the device. Likewise, optical devices, which are typically large, can obtain significant bandwidths by velocity matching the light being generated, detected or modulated with the electrical signal on the device`s electrodes. The devices discussed in this report utilize truly distributed electrical design based on slow-wave propagation to achieve velocity matching.

  9. Exploration of Wave Development during Yarn Transverse Impact

    Directory of Open Access Journals (Sweden)

    Matthew Hudspeth

    2017-05-01

    Full Text Available Single yarns have been impacted in a transverse fashion so as to probe the characteristics of resulting wave development. Longitudinal wave speeds were tracked in efforts to directly measure the yarn tensile stiffness, resulting in a slight increase in the modulus of Kevlar® KM2 and Dyneema® SK76. Additionally, the load developed in AuTx® and Kevlar® KM2 yarns behind the longitudinal wave front has been recorded, providing additional verification for the Smith relations. Further effort to bolster the Smith equations has been successfully performed via tracking transverse wave speeds in AuTx® yarns over a range of impacting velocities. Additional emphasis has been placed at understanding the transverse wave development around the yarn critical velocity, demonstrating that there is a velocity zone where partial yarn failure is detected. Above the critical velocity, measurement of early time transverse wave speeds also agrees with the Smith solution, though the wave speed quickly reduces in value due to the drop in tensile stresses resulting from filament rupture. Finally, the Smith equations have been simplified and are compared to the Cunniff equation, which bear a striking resemblance. Due to such a resemblance, it is suggested that yarn critical velocity experiments can be performed on trial yarn material, and the effect of modifying yarn mechanical properties is discussed.

  10. STX140, but not paclitaxel, inhibits mammary tumour initiation and progression in C3(1/SV40 T/t-antigen transgenic mice.

    Directory of Open Access Journals (Sweden)

    Florence Meyer-Losic

    Full Text Available Despite paclitxael's clinical success, treating hormone-refractory breast cancer remains challenging. Paclitaxel has a poor pharmacological profile, characterized by a low therapeutic index (TIX caused by severe dose limiting toxicities, such as neutropenia and peripheral neuropathy. Consequently, new drugs are urgently required. STX140, a compound previously shown to have excellent efficacy against many tumors, is here compared to paclitaxel in three translational in vivo breast cancer models, a rat model of peripheral neuropathy, and through pharmacological testing. Three different in vivo mouse models of breast cancer were used; the metastatic 4T1 orthotopic model, the C3(1/SV40 T-Ag model, and the MDA-MB-231 xenograft model. To determine TIX and pharmacological profile of STX140, a comprehensive dosing regime was performed in mice bearing MDA-MD-231 xenografts. Finally, peripheral neuropathy was examined using a rat plantar thermal hyperalgesia model. In the 4T1 metastatic model, STX140 and paclitaxel significantly inhibited primary tumor growth and lung metastases. All C3(1/SV40 T-Ag mice in the control and paclitaxel treated groups developed palpable mammary cancer. STX140 blocked 47% of tumors developing and significantly inhibited growth of tumors that did develop. STX140 treatment caused a significant (P<0.001 survival advantage for animals in early and late intervention groups. Conversely, in C3(1/SV40 T-Ag mice, paclitaxel failed to inhibit tumor growth and did not increase survival time. Furthermore, paclitaxel, but not STX140, induced significant peripheral neuropathy and neutropenia. These results show that STX140 has a greater anti-cancer efficacy, TIX, and reduced neurotoxicity compared to paclitaxel in C3(1/SV40 T-Ag mice and therefore may be of significant benefit to patients with breast cancer.

  11. Peculiarities of sea wave propagation in the Klaipėda Strait, Lithuania

    OpenAIRE

    Kriaučiūnienė, Jūratė; Gailiušis, Brunonas; Kovalenkovienė, Milda

    2006-01-01

    During rough weather, navigation in Klaipėda port is risky because of the high wave penetration into the Klaipėda Strait from the Baltic Sea. Objectives of the present paper are to study wind and wave regimes in Klaipėda port water area and to develop the short wave propagation model at wind speeds of 15, 20 and 25 m/s and varying directions. The modelled wave parameters are significant wave height and wave disturbance coefficient. The software MIKE 21 BW (Boussinesq Wave Module) is used for ...

  12. A scalable method for computing quadruplet wave-wave interactions

    Science.gov (United States)

    Van Vledder, Gerbrant

    2017-04-01

    Non-linear four-wave interactions are a key physical process in the evolution of wind generated ocean waves. The present generation operational wave models use the Discrete Interaction Approximation (DIA), but it accuracy is poor. It is now generally acknowledged that the DIA should be replaced with a more accurate method to improve predicted spectral shapes and derived parameters. The search for such a method is challenging as one should find a balance between accuracy and computational requirements. Such a method is presented here in the form of a scalable and adaptive method that can mimic both the time consuming exact Snl4 approach and the fast but inaccurate DIA, and everything in between. The method provides an elegant approach to improve the DIA, not by including more arbitrarily shaped wave number configurations, but by a mathematically consistent reduction of an exact method, viz. the WRT method. The adaptiveness is to adapt the abscissa of the locus integrand in relation to the magnitude of the known terms. The adaptiveness is extended to the highest level of the WRT method to select interacting wavenumber configurations in a hierarchical way in relation to their importance. This adaptiveness results in a speed-up of one to three orders of magnitude depending on the measure of accuracy. This definition of accuracy should not be expressed in terms of the quality of the transfer integral for academic spectra but rather in terms of wave model performance in a dynamic run. This has consequences for the balance between the required accuracy and the computational workload for evaluating these interactions. The performance of the scalable method on different scales is illustrated with results from academic spectra, simple growth curves to more complicated field cases using a 3G-wave model.

  13. Upper-mantle structure in southern Norway from beamforming of Rayleigh wave data presenting multipathing

    Science.gov (United States)

    Maupin, Valérie

    2011-05-01

    A model for the upper mantle SV-wave velocity under southern Norway is obtained by depth inversion of the average phase velocity of the Rayleigh wave fundamental mode in the area. The average dispersion curve is obtained in the period range 22-200 s by beamforming of 190 Rayleigh waves recorded by the MAGNUS network, a temporary regional network of 41 broad-band stations. Resolution of the beamforming procedure is increased by deconvolving the original beams from the array response function using the Lucy-Richardson algorithm. In addition to an average phase velocity, beamforming gives us some information concerning the nature of the incoming wavefield. We detect deviations of the wave propagation direction from the great-circle paths which commonly reach 10° at a period of 25 s for the teleseismic events. The amplitude of the deviations decreases with increasing period and with decreasing epicentral distance, as expected. The phase velocity measured by beamforming does not show any correlation with the deviation from great circle path, suggesting that deviation does not bias phase velocity measurements. We detect also significant multipathing with characteristics that vary rapidly with frequency. The obtained SV-wave velocity profile clearly shows that southern Norway is underlain by a low-velocity zone in the upper mantle and does not have shield-like characteristics, despite its location in the Baltic shield. These findings support the hypothesis that the high topography of southern Norway is sustained by anomalous upper-mantle material.

  14. Piecu svēto kalnu nozīme Ķīnas tradicionālajā pasaules skatījumā

    OpenAIRE

    Līviņš, Rolands

    2017-01-01

    Bakalaura darba „Piecu svēto kalnu nozīme Ķīnas tradicionālajā pasaules skatījumā” mērķis ir apskatīt Ķīnas Piecus svēto kalnus – vujue, to izcelsmi un nozīmi ķīniešu pasaules skatījumā. Darba gaitā ir apskatīta vujue kalnu sistēmas izveide, kas balstās uz piecu elementu teoriju. Kā arī tiek aplūkoti ar šiem kalniem un piecu elementu teoriju sasaistītie aspekti – daoistu meditāciju alas un nemirstības ideja. Darba izstrādes gaitā noskaidrots kādu lomu ieņem Pieci svētie kalni un kad tāda kaln...

  15. Development, pilot testing and psychometric validation of a short version of the coronary artery disease education questionnaire: The CADE-Q SV.

    Science.gov (United States)

    Ghisi, Gabriela Lima de Melo; Sandison, Nicole; Oh, Paul

    2016-03-01

    To develop, pilot test and psychometrically validate a shorter version of the coronary artery disease education questionnaire (CADE-Q), called CADE-Q SV. Based on previous versions of the CADE-Q, cardiac rehabilitation (CR) experts developed 20 items divided into 5 knowledge domains to comprise the first version of the CADE-Q SV. To establish content validity, they were reviewed by an expert panel (N=12). Refined items were pilot-tested in 20 patients, in which clarity was provided. A final version was generated and psychometrically-tested in 132CR patients. Test-retest reliability was assessed via the intraclass correlation coefficient (ICC), the internal consistency using Cronbach's alpha, and criterion validity with regard to patients' education and duration in CR. All ICC coefficients meet the minimum recommended standard. All domains were considered internally consistent (α>0.7). Criterion validity was supported by significant differences in mean scores by educational level (pCADE-Q SV was demonstrated to have good reliability and validity. This is a short, quick and appropriate tool for application in clinical and research settings, assessing patients' knowledge during CR and as part of education programming. Copyright © 2015. Published by Elsevier Ireland Ltd.

  16. Arginine-rich cross-linking peptides with different SV40 nuclear localization signal content as vectors for intranuclear DNA delivery.

    Science.gov (United States)

    Bogacheva, Mariia; Egorova, Anna; Slita, Anna; Maretina, Marianna; Baranov, Vladislav; Kiselev, Anton

    2017-11-01

    The major barriers for intracellular DNA transportation by cationic polymers are their toxicity, poor endosomal escape and inefficient nuclear uptake. Therefore, we designed novel modular peptide-based carriers modified with SV40 nuclear localization signal (NLS). Core peptide consists of arginine, histidine and cysteine residues for DNA condensation, endosomal escape promotion and interpeptide cross-linking, respectively. We investigated three polyplexes with different NLS content (10 mol%, 50 mol% and 90 mol% of SV40 NLS) as vectors for intranuclear DNA delivery. All carriers tested were able to condense DNA, to protect it from DNAase I and were not toxic to the cells. We observed that cell cycle arrest by hydroxyurea did not affect transfection efficacy of NLS-modified carriers which we confirmed using quantitative confocal microscopy analysis. Overall, peptide carrier modified with 90 mol% of SV40 NLS provided efficient transfection and nuclear uptake in non-dividing cells. Thus, incorporation of NLS into arginine-rich cross-linking peptides is an adequate approach to the development of efficient intranuclear gene delivery vehicles. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Intraspecific Scaling Relationships Between Crawling Speed and Body Size in a Gastropod.

    Science.gov (United States)

    Hemmert, Heather M; Baltzley, Michael J

    2016-02-01

    Across various modes of locomotion, body size and speed are often correlated both between and within species. Among the gastropods, however, current data are minimal for interspecific and intraspecific scaling relationships. In this study, we tested the relationships between various measurements of body size and crawling speed in the terrestrial snail Cornu aspersum. We also investigated the relationships between crawling speed, muscular wave frequency, and muscular wavelength, because--while these relationships within individuals are well studied--the relationships among individuals are unknown. We recorded snails crawling on both a horizontal and a vertical surface. We found that when they crawled on a horizontal surface, foot length was positively correlated with pedal wavelength and crawling speed, but was not correlated with wave frequency. In comparison, when they crawled on a vertical surface, foot length was positively correlated with wavelength, negatively correlated with wave frequency, and not correlated with crawling speed. Body mass had no correlation with crawling speed when snails were crawling on a horizontal surface, but was negatively correlated with speed when snails crawled on a vertical surface. © 2016 Marine Biological Laboratory.

  18. SUPERLUMINAL WAVES IN PULSAR WINDS

    Energy Technology Data Exchange (ETDEWEB)

    Arka, Ioanna [Current address: Institut de Planetologie et d' Astrophysique de Grenoble, UMR 5274, BP 53 F-38041 Grenoble, France. (France); Kirk, John G., E-mail: ioanna.arka@mpi-hd.mpg.de, E-mail: john.kirk@mpi-hd.mpg.de [Max-Planck-Institut fuer Kernphysik, Postfach 10 39 80, 69029 Heidelberg (Germany)

    2012-02-01

    The energy lost by a rotation-powered pulsar is carried by a relativistic flow containing a mixture of electromagnetic fields and particles. In the inner regions, this is thought to be a magnetically dominated, cold, electron-positron wind that is well described by the MHD equations. However, beyond a critical radius r{sub cr}, the same particle, energy, and momentum fluxes can be transported by a strong, transverse electromagnetic wave with superluminal phase speed. We analyze the nonlinear dispersion relation of these waves for linear and circular polarization, and find the dependence of r{sub cr} on the mass-loading, magnetization, and luminosity of the flow, as well as on the net magnetic flux. We show that, for most isolated pulsars, the wind lies well outside r{sub cr} and speculate that superluminal modes play an important role in the dissipation of electromagnetic energy into nonthermal particles at the termination shock.

  19. Speed, Acceleration, and Velocity: Level II, Unit 9, Lesson 1; Force, Mass, and Distance: Lesson 2; Types of Motion and Rest: Lesson 3; Electricity and Magnetism: Lesson 4; Electrical, Magnetic, and Gravitational Fields: Lesson 5; The Conservation and Conversion of Matter and Energy: Lesson 6; Simple Machines and Work: Lesson 7; Gas Laws: Lesson 8; Principles of Heat Engines: Lesson 9; Sound and Sound Waves: Lesson 10; Light Waves and Particles: Lesson 11; Program. A High.....

    Science.gov (United States)

    Manpower Administration (DOL), Washington, DC. Job Corps.

    This self-study program for high-school level contains lessons on: Speed, Acceleration, and Velocity; Force, Mass, and Distance; Types of Motion and Rest; Electricity and Magnetism; Electrical, Magnetic, and Gravitational Fields; The Conservation and Conversion of Matter and Energy; Simple Machines and Work; Gas Laws; Principles of Heat Engines;…

  20. Efficient Wave Energy Amplification with Wave Reflectors

    DEFF Research Database (Denmark)

    Kramer, Morten Mejlhede; Frigaard, Peter Bak

    2002-01-01

    Wave Energy Converters (WEC's) extract wave energy from a limited area, often a single point or line even though the wave energy is generally spread out along the wave crest. By the use of wave reflectors (reflecting walls) the wave energy is effectively focused and increased to approximately 130......-140%. In the paper a procedure for calculating the efficiency and optimizing the geometry of wave reflectors are described, this by use of a 3D boundary element method. The calculations are verified by laboratory experiments and a very good agreement is found. The paper gives estimates of possible power benifit...... for different geometries of the wave reflectors and optimal geometrical design parameters are specified. On this basis inventors of WEC's can evaluate whether a specific WEC possible could benefit from wave reflectors....

  1. Nonlinear waves in electromigration dispersion in a capillary

    CERN Document Server

    Christov, Ivan C

    2016-01-01

    We construct exact solutions to an unusual nonlinear advection--diffusion equation arising in the study of Taylor--Aris (also known as shear) dispersion due to electroosmotic flow during electromigration in a capillary. An exact reduction to a Darboux equation is found under a traveling-wave anzats. The equilibria of this ordinary differential equation are analyzed, showing that their stability is determined solely by the (dimensionless) wave speed without regard to any (dimensionless) physical parameters. Integral curves, connecting the appropriate equilibria of the Darboux equation that governs traveling waves, are constructed, which in turn are shown to be asymmetric kink solutions ({\\it i.e.}, non-Taylor shocks). Furthermore, it is shown that the governing Darboux equation exhibits bistability, which leads to two coexisting non-negative kink solutions for (dimensionless) wave speeds greater than unity. Finally, we give some remarks on other types of traveling-wave solutions and a discussion of some approx...

  2. Shear wave elastography with a new reliability indicator

    Directory of Open Access Journals (Sweden)

    Christoph F. Dietrich

    2016-09-01

    Full Text Available Non-invasive methods for liver stiffness assessment have been introduced over recent years. Of these, two main methods for estimating liver fibrosis using ultrasound elastography have become established in clinical practice: shear wave elastography and quasi-static or strain elastography. Shear waves are waves with a motion perpendicular (lateral to the direction of the generating force. Shear waves travel relatively slowly (between 1 and 10 m/s. The stiffness of the liver tissue can be assessed based on shear wave velocity (the stiffness increases with the speed. The European Federation of Societies for Ultrasound in Medicine and Biology has published Guidelines and Recommendations that describe these technologies and provide recommendations for their clinical use. Most of the data available to date has been published using the Fibroscan (Echosens, France, point shear wave speed measurement using an acoustic radiation force impulse (Siemens, Germany and 2D shear wave elastography using the Aixplorer (SuperSonic Imagine, France. More recently, also other manufacturers have introduced shear wave elastography technology into the market. A comparison of data obtained using different techniques for shear wave propagation and velocity measurement is of key interest for future studies, recommendations and guidelines. Here, we present a recently introduced shear wave elastography technology from Hitachi and discuss its reproducibility and comparability to the already established technologies.

  3. Speed of invasion of an expanding population by a horizontally transmitted trait.

    Science.gov (United States)

    Venegas-Ortiz, Juan; Allen, Rosalind J; Evans, Martin R

    2014-02-01

    Range expansions are a ubiquitous phenomenon, leading to the spatial spread of genetic, ecological, and cultural traits. While some of these traits are advantageous (and hence selected), other, nonselected traits can also spread by hitchhiking on the wave of population expansion. This requires us to understand how the spread of a hitchhiking trait is coupled to the wave of advance of its host population. Here, we use a system of coupled Fisher-Kolmogorov-Petrovsky-Piskunov (F-KPP) equations to describe the spread of a horizontally transmitted hitchhiking trait within a population as it expands. We extend F-KPP wave theory to the system of coupled equations to predict how the hitchhiking trait spreads as a wave within the expanding population. We show that the speed of this trait wave is controlled by an intricate coupling between the tip of the population and trait waves. Our analysis yields a new speed selection mechanism for coupled waves of advance and reveals the existence of previously unexpected speed transitions.

  4. Estimation of beat-to-beat changes in stroke volume from arterial pressure: a comparison of two pressure wave analysis techniques during head-up tilt testing in young, healthy men

    NARCIS (Netherlands)

    Jellema, W. T.; Imholz, B. P.; Oosting, H.; Wesseling, K. H.; van Lieshout, J. J.

    1999-01-01

    OBJECTIVE: The aim of this study was to compare beat-to-beat changes in stroke volume (SV) estimated by two different pressure wave analysis techniques during orthostatic stress testing: pulse contour analysis and Modelflow, i.e., simulation of a three-element model of aortic input impedance.

  5. Estimation of beat-to-beat changes in stroke volume from arterial pressure: A comparison of two pressure wave analysis techniques during head- up tilt testing in young, healthy men

    NARCIS (Netherlands)

    Jellema, W.T.; Imholz, B.P.M.; Oosting, H.; Wesseling, K.H.; Lieshout, J.J. van

    1999-01-01

    Objective: The aim of this study was to compare beat-to-beat changes in stroke volume (SV) estimated by two different pressure wave analysis techniques during orthostatic stress testing: pulse contour analysis and Modelflow, ie, simulation of a three-element model of aortic input impedance. Methods:

  6. What controls the speed of rip currents? Comparing field observations, numerical simulations, and a parameterization

    Science.gov (United States)

    Moulton, M.; Elgar, S.; Raubenheimer, B.; Warner, J. C.

    2016-02-01

    Wave breaking on alongshore non-uniform beaches can drive rip currents near bathymetric depressions. Understanding the controls on the speed of these offshore-directed flows is important for improving predictions of beach hazards, the transport of pollutants and larvae, and morphological evolution. To investigate the response of nearshore flows to non-uniform bathymetry, five channels (on average 30-m wide and 2-m deep) were dredged across the surf zone on the Outer Banks of NC at different times using the propellers of a landing craft, and the subsequent evolution of waves, currents, and morphology was observed for a range of incident wave conditions. In addition, flows are simulated with the COAWST modeling system for the observed incident waves and rip channel bathymetry, and for an extended range of wave conditions and rip channel geometries. A parameter for the maximum offshore-directed flow speed in the surf zone is derived using depth-averaged momentum balances and continuity. The most important terms controlling the offshore-directed flow (rip current) speed are the incident wave height and angle, the water depths in the channel and on the sandbar crest or the terrace through which the channel is incised, and the ratio of wave height to water depth at breaking. The parameter accounts for several wave-breaking regimes, and includes the effect of the suppression of cross-shore flows by the inertia of breaking-wave driven alongshore currents. The parameter has skill predicting the observed and simulated offshore-directed flow speed. Supported by ASDR&E, NDSEG, ONR, and NSF.

  7. High speed rail distribution study.

    Science.gov (United States)

    2016-08-01

    The Texas Central Partners are in the process of developing a high speed rail line connecting : Houston and Dallas, Texas. Ultimately, plans are for 8 car trains that accommodate 200 people per : vehicle scheduled every 30 minutes. In addition, Texas...

  8. Predictors of Social Mobilization Speed

    CERN Document Server

    Alstott, Jeff; Velu, Chander

    2013-01-01

    Mobilization across social networks is becoming increasingly influential, but little is known about what traits of individuals and their relationships affect their speed of mobilization between them. We ran a global social mobilization contest and recorded personal traits of the participants and those they mobilized. We examined how those traits influenced the speed of mobilization. Individuals mobilized faster when they heard about the contest directly from the contest organization, and decreased in speed when hearing from less personal source types (e.g. family vs. media). Mobilization was faster when the mobilizer and the mobilized heard about the contest through the same source type, and slower when both individuals were in different countries. Females mobilized other females faster than males mobilized other males. Mobilization was faster with young recruiters and old recruits, and slower with old recruiters and young recruits. These findings suggest ways to optimize the speed of social mobilization.

  9. Dynamic Dazzle Distorts Speed Perception.

    Directory of Open Access Journals (Sweden)

    Joanna R Hall

    Full Text Available Static high contrast ('dazzle' patterns, such as zigzags, have been shown to reduce the perceived speed of an object. It has not escaped our notice that this effect has possible military applications and here we report a series of experiments on humans, designed to establish whether dynamic dazzle patterns can cause distortions of perceived speed sufficient to provide effective defence in the field, and the extent to which these effects are robust to a battery of manipulations. Dynamic stripe patterns moving in the same direction as the target are found to increase the perceived speed of that target, whilst dynamic stripes moving in the opposite direction to the target reduce the perceived speed. We establish the optimum position for such dazzle patches; confirm that reduced contrast and the addition of colour do not affect the performance of the dynamic dazzle, and finally, using the CO2 challenge, show that the effect is robust to stressful conditions.

  10. High-Speed Electrochemical Imaging.

    Science.gov (United States)

    Momotenko, Dmitry; Byers, Joshua C; McKelvey, Kim; Kang, Minkyung; Unwin, Patrick R

    2015-09-22

    The design, development, and application of high-speed scanning electrochemical probe microscopy is reported. The approach allows the acquisition of a series of high-resolution images (typically 1000 pixels μm(-2)) at rates approaching 4 seconds per frame, while collecting up to 8000 image pixels per second, about 1000 times faster than typical imaging speeds used up to now. The focus is on scanning electrochemical cell microscopy (SECCM), but the principles and practicalities are applicable to many electrochemical imaging methods. The versatility of the high-speed scan concept is demonstrated at a variety of substrates, including imaging the electroactivity of a patterned self-assembled monolayer on gold, visualization of chemical reactions occurring at single wall carbon nanotubes, and probing nanoscale electrocatalysts for water splitting. These studies provide movies of spatial variations of electrochemical fluxes as a function of potential and a platform for the further development of high speed scanning with other electrochemical imaging techniques.

  11. Properties of Longitudinal Flux Tube Waves. III; Wave Propagation in Solar and Stellar Wind FLows

    Science.gov (United States)

    Cuntz, M.; Suess, S. T.

    2004-01-01

    We discuss the analytic properties of longitudinal tube waves taking into account ambient wind flows. This is an extension of the studies of Papers I and II, which assumed a mean flow speed of zero and also dealt with a simplified horizontal pressure balance. Applications include the study of longitudinal flux tube waves in stars with significant mass loss and the heating and dynamics of plumes in the solar wind. Slow magnetosonic waves, also called longitudinal waves, have been observed in solar plumes and are likely an important source of heating. We show that the inclusion of ambient wind flows considerably alters the limiting shock strength as well as the energy damping length of the waves.

  12. Speed management : enforcement and new technologies.

    NARCIS (Netherlands)

    Wegman, F.C.M. & Goldenbeld, C.

    2006-01-01

    Due to the massive character of speeding and inappropriate travel speeds, speed management continues to be an important and challenging policy area. Estimates are that in about a quarter to one third of fatal crashes excessive speeds are involved, making speed one of the crucial factors in road

  13. Gravity wave reflection: Case study based on rocket data

    Science.gov (United States)

    Wüst, Sabine; Bittner, Michael

    2008-03-01

    Since gravity waves significantly influence the atmosphere by transporting energy and momentum, it is important to study their wave spectrum and their energy dissipation rates. Besides that, knowledge about gravity wave sources and the propagation of the generated waves is essential. Originating in the lower atmosphere, gravity waves can move upwards; when the background wind field is equal to their phase speed a so-called critical layer is reached. Their breakdown and deposition of energy and momentum is possible. Another mechanism which can take place at critical layers is gravity wave reflection. In this paper, gravity waves which were observed by foil chaff measurements during the DYANA (DYnamics Adapted Network for the Atmosphere) campaign in 1990 in Biscarrosse (44°N, 1°W)--as reported by Wüst and Bittner [2006. Non-linear wave-wave interaction: case studies based on rocket data and first application to satellite data. Journal of Atmospheric and Solar-Terrestrial Physics 68, 959-976]--are investigated to look for gravity wave reflection processes. Following nonlinear theory, energy dissipation rates according to Weinstock [1980. Energy dissipation rates of turbulence in the stable free atmosphere. Journal of the Atmospheric Sciences 38, 880-883] are calculated from foil chaff cloud and falling sphere data and compared with the critical layer heights. Enhanced energy dissipation rates are found at those altitudes where the waves' phase speed matches the zonal background wind speeds. Indication of gravity wave trapping is found between two altitudes of around 95 and 86 km.

  14. Wave-climate assessment by satellite remote sensing

    Energy Technology Data Exchange (ETDEWEB)

    Barstow, S.; Krogstad, H.E. [SINTEF, Trodheim (Norway)

    1995-10-01

    Satellite remote sensing based on radar altimetry and the synthetic aperture radar (SAR) can be used for accurate ocean-wave climatology globally. The altimeter provides significant wave height and wind speed whereas SAR in principle gives the full wave spectrum. Over the next few years, altimeter-derived wave heights will become the basic data sources for open-ocean statistics and SAR, in combination with results from global wave models, will provide the corresponding directional statistics. In addition, SAR may be used for studying wave conditions in near coastal areas. In the Norwegian Sea and elsewhere, real-time SAT and altimeter data are now being used operationally for forecasting and assimilation into numerical wave models.

  15. Travelling waves in hybrid chemotaxis models

    CERN Document Server

    Franz, Benjamin; Painter, Kevin J; Erban, Radek

    2013-01-01

    Hybrid models of chemotaxis combine agent-based models of cells with partial differential equation models of extracellular chemical signals. In this paper, travelling wave properties of hybrid models of bacterial chemotaxis are investigated. Bacteria are modelled using an agent-based (individual-based) approach with internal dynamics describing signal transduction. In addition to the chemotactic behaviour of the bacteria, the individual-based model also includes cell proliferation and death. Cells consume the extracellular nutrient field (chemoattractant) which is modelled using a partial differential equation. Mesoscopic and macroscopic equations representing the behaviour of the hybrid model are derived and the existence of travelling wave solutions for these models is established. It is shown that cell proliferation is necessary for the existence of non-transient (stationary) travelling waves in hybrid models. Additionally, a numerical comparison between the wave speeds of the continuum models and the hybr...

  16. Individual external doses below the lowest reference level of 1 mSv per year five years after the 2011 Fukushima nuclear accident among all children in Soma City, Fukushima: A retrospective observational study.

    Science.gov (United States)

    Tsubokura, Masaharu; Murakami, Michio; Nomura, Shuhei; Morita, Tomohiro; Nishikawa, Yoshitaka; Leppold, Claire; Kato, Shigeaki; Kami, Masahiro

    2017-01-01

    After the 2011 Fukushima Daiichi nuclear power plant accident, little information has been available on individual doses from external exposure among residents living in radioactively contaminated areas near the nuclear plant; in the present study we evaluated yearly changes in the doses from external exposure after the accident and the effects of decontamination on external exposure. This study considered all children less than 16 years of age in Soma City, Fukushima who participated in annual voluntary external exposure screening programs during the five years after the accident (n = 5,363). In total, 14,405 screening results were collected. The median participant age was eight years. The geometric mean levels of annual additional doses from external exposure attributable to the Fukushima accident, decreased each year: 0.60 mSv (range: not detectable (ND)-4.29 mSv), 0.37 mSv (range: ND-3.61 mSv), 0.22 mSv (range: ND-1.44 mSv), 0.20 mSv (range: ND-1.87 mSv), and 0.17 mSv (range: ND-0.85 mSv) in 2011, 2012, 2013, 2014, and 2015, respectively. The proportion of residents with annual additional doses from external exposure of more than 1 mSv dropped from 15.6% in 2011 to zero in 2015. Doses from external exposure decreased more rapidly than those estimated from only physical decay, even in areas without decontamination (which were halved in 395 days from November 15, 2011), presumably due to the weathering effects. While the ratios of geometric mean doses immediately after decontamination to before were slightly lower than those during the same time in areas without decontamination, annual additional doses reduced by decontamination were small (0.04-0.24 mSv in the year of immediately after decontamination was completed). The results of this study showed that the levels of external exposure among Soma residents less than 16 years of age decreased during the five years after the Fukushima Daiichi nuclear power plant accident. Decontamination had only limited and

  17. Drifting waves in Saturn's C ring, evidence for changes in Saturn's interior

    Science.gov (United States)

    Hedman, Matthew M.; El Moutamid, Maryame; Nicholson, Philip D.

    2017-06-01

    Recent analyses of spiral density waves in Saturn's C ring have revealed that many of these waves are generated by either normal-mode oscillations or asymmetries in Saturn's interior. The waves generated by normal-mode oscillations exhibit remarkably stable pattern speeds, indicating that the oscillations inside the planet that generate these waves have frequencies that remain constant for years to decades. However, close inspection of the waves with pattern speeds close to Saturn's rotation rate reveals that several of these waves have been moving inwards over the course of the Cassini mission at rates of around 1 kilometer per year. These "drifting waves" suggest that the frequencies of the relevant driving forces are increasing over time. Hence some aspect of Saturn's internal structure must be slowly changing on decadal timescales. Furthermore, since these waves are generated by forces that are not strictly periodic, they provide new opportunities to examine how disturbances propagate within dense rings.

  18. Piezoelectric parametric effects on wave vibration and contact mechanics of traveling wave ultrasonic motor.

    Science.gov (United States)

    Zhang, Dongsheng; Wang, Shiyu; Xiu, Jie

    2017-11-01

    Elastic wave quality determines the operating performance of traveling wave ultrasonic motor (TWUM). The time-variant circumferential force from the shrink of piezoelectric ceramic is one of the factors that distort the elastic wave. The distorted waveshape deviates from the ideal standard sinusoidal fashion and affects the contact mechanics and driving performance. An analytical dynamic model of ring ultrasonic motor is developed. Based on this model, the piezoelectric parametric effects on the wave distortion and contact mechanics are examined. Multi-scale method is employed to obtain unstable regions and distorted wave response. The unstable region is verified by Floquét theory. Since the waveshape affects the contact mechanism, a contact model involving the distorted waveshape and normal stiffness of the contact layer is established. The contact model is solved by numerical calculation. The results verify that the deformation of the contact layer deviates from sinusoidal waveshape and the pressure distribution is changed, which influences the output characteristics directly. The surface speed within the contact region is averaged such that the rotor speed decreases for lower torque and increases for larger torque. The effects from different parametric strengths, excitation frequencies and pre-pressures on pressure distribution and torque-speed relation are compared. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. The physics of waves

    CERN Document Server

    Georgi, Howard

    1993-01-01

    The first complete introduction to waves and wave phenomena by a renowned theorist. Covers damping, forced oscillations and resonance; normal modes; symmetries; traveling waves; signals and Fourier analysis; polarization; diffraction.

  20. Hexapod Walking Robot Energy Consumption Dependence On Different Gaits And Speed While Moving On Even Terrain

    Directory of Open Access Journals (Sweden)

    Mindaugas Luneckas

    2014-05-01

    Full Text Available Evaluation of robotic energetics while moving on rough terrain becomes a difficult task without having the information about the movement on even terrain. The problem appears in selection of gaits depending on how much power robot consumes. In this paper, energy consumption of a hexapod walking robot dependence on different gaits and speed is observed. Three most common gaits were used in this experiment: tripod gait, bipod gait and wave gait. Results clearly show that while moving at slow speed, the least energy is consumed by wave gait. As the speed increases, bipod gait selection is required to lower energy consumption. Finally, tripod gait must be selected at even higher speed.

  1. A wave dynamical interpretation of Saturn's polar hexagon

    Science.gov (United States)

    Allison, M.; Godfrey, D. A.; Beebe, R. F.

    1990-01-01

    The hexagonal, pole-centered cloud feature in Saturn's northern atmosphere, as revealed in Voyager close-encounter imaging mosaics, may be interpreted as a stationary Rossby wave. The wave is embedded within a sharply peaked eastward jet (of 100 meters per second) and appears to be perturbed by at least one anticyclonic oval vortex immediately to the south. The effectively exact observational determination of the horizontal wave number and phase speed, applied to a simple model dispersion relation, suggests that the wave is vertically trapped and provides a diagnostic template for further modeling of the deep atmospheric stratification.

  2. Speed estimation for air quality analysis.

    Science.gov (United States)

    2005-05-01

    Average speed is an essential input to the air quality analysis model MOBILE6 for emission factor calculation. Traditionally, speed is obtained from travel demand models. However, such models are not usually calibrated to speeds. Furthermore, for rur...

  3. Snakes mimic earthworms: propulsion using rectilinear travelling waves

    Science.gov (United States)

    Marvi, Hamidreza; Bridges, Jacob; Hu, David L.

    2013-01-01

    In rectilinear locomotion, snakes propel themselves using unidirectional travelling waves of muscular contraction, in a style similar to earthworms. In this combined experimental and theoretical study, we film rectilinear locomotion of three species of snakes, including red-tailed boa constrictors, Dumeril's boas and Gaboon vipers. The kinematics of a snake's extension–contraction travelling wave are characterized by wave frequency, amplitude and speed. We find wave frequency increases with increasing body size, an opposite trend than that for legged animals. We predict body speed with 73–97% accuracy using a mathematical model of a one-dimensional n-linked crawler that uses friction as the dominant propulsive force. We apply our model to show snakes have optimal wave frequencies: higher values increase Froude number causing the snake to slip; smaller values decrease thrust and so body speed. Other choices of kinematic variables, such as wave amplitude, are suboptimal and appear to be limited by anatomical constraints. Our model also shows that local body lifting increases a snake's speed by 31 per cent, demonstrating that rectilinear locomotion benefits from vertical motion similar to walking. PMID:23635494

  4. Low speed phaselock speed control system. [for brushless dc motor

    Science.gov (United States)

    Fulcher, R. W.; Sudey, J. (Inventor)

    1975-01-01

    A motor speed control system for an electronically commutated brushless dc motor is provided which includes a phaselock loop with bidirectional torque control for locking the frequency output of a high density encoder, responsive to actual speed conditions, to a reference frequency signal, corresponding to the desired speed. The system includes a phase comparator, which produces an output in accordance with the difference in phase between the reference and encoder frequency signals, and an integrator-digital-to-analog converter unit, which converts the comparator output into an analog error signal voltage. Compensation circuitry, including a biasing means, is provided to convert the analog error signal voltage to a bidirectional error signal voltage which is utilized by an absolute value amplifier, rotational decoder, power amplifier-commutators, and an arrangement of commutation circuitry.

  5. Modification of wave propagation and wave travel-time by the presence of magnetic fields in the solar network atmosphere

    Science.gov (United States)

    Nutto, C.; Steiner, O.; Schaffenberger, W.; Roth, M.

    2012-02-01

    Context. Observations of waves at frequencies above the acoustic cut-off frequency have revealed vanishing wave travel-times in the vicinity of strong magnetic fields. This detection of apparently evanescent waves, instead of the expected propagating waves, has remained a riddle. Aims: We investigate the influence of a strong magnetic field on the propagation of magneto-acoustic waves in the atmosphere of the solar network. We test whether mode conversion effects can account for the shortening in wave travel-times between different heights in the solar atmosphere. Methods: We carry out numerical simulations of the complex magneto-atmosphere representing the solar magnetic network. In the simulation domain, we artificially excite high frequency waves whose wave travel-times between different height levels we then analyze. Results: The simulations demonstrate that the wave travel-time in the solar magneto-atmosphere is strongly influenced by mode conversion. In a layer enclosing the surface sheet defined by the set of points where the Alfvén speed and the sound speed are equal, called the equipartition level, energy is partially transferred from the fast acoustic mode to the fast magnetic mode. Above the equipartition level, the fast magnetic mode is refracted due to the large gradient of the Alfvén speed. The refractive wave path and the increasing phase speed of the fast mode inside the magnetic canopy significantly reduce the wave travel-time, provided that both observing levels are above the equipartition level. Conclusions: Mode conversion and the resulting excitation and propagation of fast magneto-acoustic waves is responsible for the observation of vanishing wave travel-times in the vicinity of strong magnetic fields. In particular, the wave propagation behavior of the fast mode above the equipartition level may mimic evanescent behavior. The present wave propagation experiments provide an explanation of vanishing wave travel-times as observed with multi

  6. Numerical modeling of wind waves in the Black Sea generated by atmospheric cyclones

    Science.gov (United States)

    Fomin, V. V.

    2017-09-01

    The influence of the translation speed and intensity of atmospheric cyclones on surface wind waves in the Black Sea is investigated by using tightly-coupled model SWAN+ADCIRC. It is shown that the wave field has a spatial asymmetry, which depends on the velocity and intensity of the cyclone. The region of maximum waves is formed to the right of the direction of the cyclone motion. Speedier cyclones generate wind waves of lower height. The largest waves are generated at cyclonic translation speed of 7-9 m/s. This effect is due to the coincidence of the characteristic values of the group velocity of the dominant wind waves in the deep-water part of the Black Sea with the cyclone translation speed.

  7. Geosynchronous Relativistic Electron Events Associated with High-Speed Solar Wind Streams in 2006

    Directory of Open Access Journals (Sweden)

    Sungeun Lee

    2009-12-01

    Full Text Available Recurrent enhancements of relativistic electron events at geosynchronous orbit (GREEs were observed in 2006. These GREE enhancements were associated with high-speed solar wind streams coming from the same coronal hole. For the first six months of 2006, the occurrence of GREEs has 27 day periodicity and the GREEs were enhanced with various flux levels. Several factors have been studied to be related to GREEs: (1 High speed stream, (2 Pc5 ULF wave activity, (3 Southward IMF Bz, (4 substorm occurrence, (5 Whistler mode chorus wave, and (6 Dynamic pressure. In this paper, we have examined the effectiveness about those parameters in selected periods.

  8. Assessment of modern methods in numerical simulations of high speed flows

    Science.gov (United States)

    Pindera, M. Z.; Yang, H. Q.; Przekwas, A. J.; Tucker, K.

    1992-01-01

    Results of extensive studies on CFD algorithms for 2D inviscid flows in Cartesian and body fitted coordinates geometries are reviewed. These studies represent part of an ongoing investigation of combustion instabilities involving the interactions of high-speed nonlinear acoustic waves. Four numerical methods for the treatment of high speed flows are compared, namely, Roe-Sweby TVD, Yee symmetric TVD; Osher-Chakravarthy TVD; and the Colella's multi-dimensional Godunov method.

  9. Climate change impact on wave energy in the Persian Gulf

    Science.gov (United States)

    Kamranzad, Bahareh; Etemad-Shahidi, Amir; Chegini, Vahid; Yeganeh-Bakhtiary, Abbas

    2015-06-01

    Excessive usage of fossil fuels and high emission of greenhouse gases have increased the earth's temperature, and consequently have changed the patterns of natural phenomena such as wind speed, wave height, etc. Renewable energy resources are ideal alternatives to reduce the negative effects of increasing greenhouse gases emission and climate change. However, these energy sources are also sensitive to changing climate. In this study, the effect of climate change on wave energy in the Persian Gulf is investigated. For this purpose, future wind data obtained from CGCM3.1 model were downscaled using a hybrid approach and modification factors were computed based on local wind data (ECMWF) and applied to control and future CGCM3.1 wind data. Downscaled wind data was used to generate the wave characteristics in the future based on A2, B1, and A1B scenarios, while ECMWF wind field was used to generate the wave characteristics in the control period. The results of these two 30-yearly wave modelings using SWAN model showed that the average wave power changes slightly in the future. Assessment of wave power spatial distribution showed that the reduction of the average wave power is more in the middle parts of the Persian Gulf. Investigation of wave power distribution in two coastal stations (Boushehr and Assalouyeh ports) indicated that the annual wave energy will decrease in both stations while the wave power distribution for different intervals of significant wave height and peak period will also change in Assalouyeh according to all scenarios.

  10. A Continuum Model of Actin Waves in Dictyostelium discoideum

    Science.gov (United States)

    Khamviwath, Varunyu; Hu, Jifeng; Othmer, Hans G.

    2013-01-01

    Actin waves are complex dynamical patterns of the dendritic network of filamentous actin in eukaryotes. We developed a model of actin waves in PTEN-deficient Dictyostelium discoideum by deriving an approximation of the dynamics of discrete actin filaments and combining it with a signaling pathway that controls filament branching. This signaling pathway, together with the actin network, contains a positive feedback loop that drives the actin waves. Our model predicts the structure, composition, and dynamics of waves that are consistent with existing experimental evidence, as well as the biochemical dependence on various protein partners. Simulation suggests that actin waves are initiated when local actin network activity, caused by an independent process, exceeds a certain threshold. Moreover, diffusion of proteins that form a positive feedback loop with the actin network alone is sufficient for propagation of actin waves at the observed speed of . Decay of the wave back can be caused by scarcity of network components, and the shape of actin waves is highly dependent on the filament disassembly rate. The model allows retraction of actin waves and captures formation of new wave fronts in broken waves. Our results demonstrate that a delicate balance between a positive feedback, filament disassembly, and local availability of network components is essential for the complex dynamics of actin waves. PMID:23741312

  11. Brushless tachometer gives speed and direction

    Science.gov (United States)

    Nola, F. J.

    1977-01-01

    Brushless electronic tachometer measures rotational speed and rotational direction, maintaining accuracy at high or low speeds. Unit is particularly useful in vacuum environments requiring low friction.

  12. Dazzle camouflage affects speed perception.

    Directory of Open Access Journals (Sweden)

    Nicholas E Scott-Samuel

    Full Text Available Movement is the enemy of camouflage: most attempts at concealment are disrupted by motion of the target. Faced with this problem, navies in both World Wars in the twentieth century painted their warships with high contrast geometric patterns: so-called "dazzle camouflage". Rather than attempting to hide individual units, it was claimed that this patterning would disrupt the perception of their range, heading, size, shape and speed, and hence reduce losses from, in particular, torpedo attacks by submarines. Similar arguments had been advanced earlier for biological camouflage. Whilst there are good reasons to believe that most of these perceptual distortions may have occurred, there is no evidence for the last claim: changing perceived speed. Here we show that dazzle patterns can distort speed perception, and that this effect is greatest at high speeds. The effect should obtain in predators launching ballistic attacks against rapidly moving prey, or modern, low-tech battlefields where handheld weapons are fired from short ranges against moving vehicles. In the latter case, we demonstrate that in a typical situation involving an RPG7 attack on a Land Rover the reduction in perceived speed is sufficient to make the grenade miss where it was aimed by about a metre, which could be the difference between survival or not for the occupants of the vehicle.

  13. Generalized Geometric Quantum Speed Limits

    Directory of Open Access Journals (Sweden)

    Diego Paiva Pires

    2016-06-01

    Full Text Available The attempt to gain a theoretical understanding of the concept of time in quantum mechanics has triggered significant progress towards the search for faster and more efficient quantum technologies. One of such advances consists in the interpretation of the time-energy uncertainty relations as lower bounds for the minimal evolution time between two distinguishable states of a quantum system, also known as quantum speed limits. We investigate how the nonuniqueness of a bona fide measure of distinguishability defined on the quantum-state space affects the quantum speed limits and can be exploited in order to derive improved bounds. Specifically, we establish an infinite family of quantum speed limits valid for unitary and nonunitary evolutions, based on an elegant information geometric formalism. Our work unifies and generalizes existing results on quantum speed limits and provides instances of novel bounds that are tighter than any established one based on the conventional quantum Fisher information. We illustrate our findings with relevant examples, demonstrating the importance of choosing different information metrics for open system dynamics, as well as clarifying the roles of classical populations versus quantum coherences, in the determination and saturation of the speed limits. Our results can find applications in the optimization and control of quantum technologies such as quantum computation and metrology, and might provide new insights in fundamental investigations of quantum thermodynamics.

  14. Spatial layout affects speed discrimination

    Science.gov (United States)

    Verghese, P.; Stone, L. S.

    1997-01-01

    We address a surprising result in a previous study of speed discrimination with multiple moving gratings: discrimination thresholds decreased when the number of stimuli was increased, but remained unchanged when the area of a single stimulus was increased [Verghese & Stone (1995). Vision Research, 35, 2811-2823]. In this study, we manipulated the spatial- and phase relationship between multiple grating patches to determine their effect on speed discrimination thresholds. In a fusion experiment, we merged multiple stimulus patches, in stages, into a single patch. Thresholds increased as the patches were brought closer and their phase relationship was adjusted to be consistent with a single patch. Thresholds increased further still as these patches were fused into a single patch. In a fission experiment, we divided a single large patch into multiple patches by superimposing a cross with luminance equal to that of the background. Thresholds decreased as the large patch was divided into quadrants and decreased further as the quadrants were maximally separated. However, when the cross luminance was darker than the background, it was perceived as an occluder and thresholds, on average, were unchanged from that for the single large patch. A control experiment shows that the observed trend in discrimination thresholds is not due to the differences in perceived speed of the stimuli. These results suggest that the parsing of the visual image into entities affects the combination of speed information across space, and that each discrete entity effectively provides a single independent estimate of speed.

  15. Mobile app reading speed test.

    Science.gov (United States)

    Kingsnorth, Alec; Wolffsohn, James S

    2015-04-01

    To validate the accuracy and repeatability of a mobile app reading speed test compared with the traditional paper version. Twenty-one subjects wearing their full refractive correction glasses read 14 sentences of decreasing print size between 1.0 and -0.1 logMAR, each consisting of 14 words (Radner reading speed test) at 40 cm with a paper-based chart and twice on iPad charts. Time duration was recorded with a stop watch for the paper chart and on the App itself for the mobile chart allowing critical print size (CPS) and optimal reading speed (ORS) to be derived objectively. The ORS was higher for the mobile app charts (194±29 wpm; 195±25 wpm) compared with the paper chart (166±20 wpm; F=57.000, preading speed test is as good (ORS) or better (CPS) than previous studies on the paper test. While the results are not interchangeable with paper-based charts, mobile app tablet-based tests of reading speed are reliable and rapid to perform, with the potential to capture functional visual ability in research studies and clinical practice. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. Experimental investigation of cylindrical detonation wave

    Science.gov (United States)

    Dudin, S. V.; Sosikov, V. A.; Torunov, S. I.

    2016-11-01

    One of the methods of experimental investigation of cylindrical detonation wave formed by the multipoint initiation method is presented in this work. The experimental setup was specially developed for this purpose. Two types of “Nanogate” high-speed cameras were used in the experiments. The phenomenological descriptions of initiation process, dynamic of formation of detonation wave and gas dynamic flow of detonation products are presented. This method in combination with the other modern methods will allow carrying out more profound investigations of such problems.

  17. Reconfigurable metamaterials for terahertz wave manipulation

    Science.gov (United States)

    Hashemi, Mohammed R.; Cakmakyapan, Semih; Jarrahi, Mona

    2017-09-01

    Reconfigurable metamaterials have emerged as promising platforms for manipulating the spectral and spatial properties of terahertz waves without being limited by the characteristics of naturally existing materials. Here, we present a comprehensive overview of various types of reconfigurable metamaterials that are utilized to manipulate the intensity, phase, polarization, and propagation direction of terahertz waves. We discuss various reconfiguration mechanisms based on optical, electrical, thermal, and mechanical stimuli while using semiconductors, superconductors, phase-change materials, graphene, and electromechanical structures. The advantages and disadvantages of different reconfigurable metamaterial designs in terms of modulation efficiency, modulation bandwidth, modulation speed, and system complexity are discussed in detail.

  18. Internal waves and temperature fronts on slopes

    Directory of Open Access Journals (Sweden)

    S. A. Thorpe

    Full Text Available Time series measurements from an array of temperature miniloggers in a line at constant depth along the sloping boundary of a lake are used to describe the `internal surf zone' where internal waves interact with the sloping boundary. More small positive temperature time derivatives are recorded than negative, but there are more large negative values than positive, giving the overall distribution of temperature time derivatives a small negative skewness. This is consistent with the internal wave dynamics; fronts form during the up-slope phase of the motion, bringing cold water up the slope, and the return flow may become unstable, leading to small advecting billows and weak warm fronts. The data are analysed to detect `events', periods in which the temperature derivatives exceed a set threshold. The speed and distance travelled by `events' are described. The motion along the slope may be a consequence of (a instabilities advected by the flow (b internal waves propagating along-slope or (c internal waves approaching the slope from oblique directions. The propagation of several of the observed 'events' can only be explained by (c, evidence that the internal surf zone has some, but possibly not all, the characteristics of the conventional 'surface wave' surf zone, with waves steepening as they approach the slope at oblique angles.

    Key words. Oceanography: general (benthic boundary layers; limnology, Oceanography: physical (internal and inertial waves

  19. Assessment of wave energy resources in Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    Stopa, Justin E.; Cheung, Kwok Fai [Department of Ocean and Resources Engineering, University of Hawaii at Manoa, Honolulu, HI 96822 (United States); Chen, Yi-Leng [Department of Meteorology, University of Hawaii at Manoa, Honolulu, HI 96822 (United States)

    2011-02-15

    Hawaii is subject to direct approach of swells from distant storms as well as seas generated by trade winds passing through the islands. The archipelago creates a localized weather system that modifies the wave energy resources from the far field. We implement a nested computational grid along the major Hawaiian Islands in the global WaveWatch3 (WW3) model and utilize the Weather Research and Forecast (WRF) model to provide high-resolution mesoscale wind forcing over the Hawaii region. Two hindcast case studies representative of the year-round conditions provide a quantitative assessment of the regional wind and wave patterns as well as the wave energy resources along the Hawaiian Island chain. These events of approximately two weeks each have a range of wind speeds, ground swells, and wind waves for validation of the model system with satellite and buoy measurements. The results demonstrate the wave energy potential in Hawaii waters. While the episodic swell events have enormous power reaching 60 kW/m, the wind waves, augmented by the local weather, provide a consistent energy resource of 15-25 kW/m throughout the year. (author)

  20. Experimental investigation of shock wave - bubble interaction

    Energy Technology Data Exchange (ETDEWEB)

    Alizadeh, Mohsen

    2010-04-09

    In this work, the dynamics of laser-generated single cavitation bubbles exposed to lithotripter shock waves has been investigated experimentally. The energy of the impinging shock wave is varied in several steps. High-speed photography and pressure field measurements simultaneously with image acquisition provide the possibility of capturing the fast bubble dynamics under the effect of the shock wave impact. The pressure measurement is performed using a fiber optic probe hydrophone (FOPH) which operates based on optical diagnostics of the shock wave propagating medium. After a short introduction in chapter 1 an overview of the previous studies in chapter 2 is presented. The reported literatures include theoretical and experimental investigations of several configurations of physical problems in the field of bubble dynamics. In chapter 3 a theoretical description of propagation of a shock wave in a liquid like water has been discussed. Different kinds of reflection of a shock wave at an interface are taken into account. Undisturbed bubble dynamics as well as interaction between a planar shock wave and an initially spherical bubble are explored theoretically. Some physical parameters which are important in this issue such as the velocity of the shock-induced liquid jet, Kelvin impulse and kinetic energy are explained. The shock waves are generated in a water filled container by a focusing piezoelectric generator. The shock wave profile has a positive part with pulse duration of ∼1 μs followed by a longer tension tail (i.e. ∼3 μs). In chapter 4 high-speed images depict the propagation of a shock wave in the water filled tank. The maximum pressure is also derived for different intensity levels of the shock wave generator. The measurement is performed in the free field (i.e. in the absence of laser-generated single bubbles). In chapter 5 the interaction between lithotripter shock waves and laserinduced single cavitation bubbles is investigated experimentally. An