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Sample records for sustained lung inflation

  1. Manual Ventilation and Sustained Lung Inflation in an Experimental Model: Influence of Equipment Type and Operator’s Training

    National Research Council Canada - National Science Library

    do Prado, Cristiane; Guinsburg, Ruth; de Almeida, Maria Fernanda Branco; Mascaretti, Renata Suman; Vale, Luciana Assis; Haddad, Luciana Branco; Rebello, Celso Moura

    2016-01-01

    .... Participants ventilated an intubated manikin. To evaluate respiratory mechanics and sustained lung inflation parameters, a direct comparison was made between the self-inflating bag and the T-shaped resuscitator (T-piece...

  2. Manual Ventilation and Sustained Lung Inflation in an Experimental Model: Influence of Equipment Type and Operator's Training.

    Science.gov (United States)

    do Prado, Cristiane; Guinsburg, Ruth; de Almeida, Maria Fernanda Branco; Mascaretti, Renata Suman; Vale, Luciana Assis; Haddad, Luciana Branco; Rebello, Celso Moura

    2016-01-01

    To compare the influence of devices for manual ventilation and individual experience on the applied respiratory mechanics and sustained lung inflation. A total of 114 instructors and non-instructors from the Neonatal Resuscitation Program of the Brazilian Society of Pediatrics participated in this study. Participants ventilated an intubated manikin. To evaluate respiratory mechanics and sustained lung inflation parameters, a direct comparison was made between the self-inflating bag and the T-shaped resuscitator (T-piece), followed by an analysis of the effectiveness of the equipment according to the participants' education and training. A difference between equipment types was observed for the tidal volume, with a median (interquartile range) of 28.5 mL (12.6) for the self-inflating bag and 20.1 mL (8.4) for the T-piece in the instructor group and 31.6 mL (14) for the self-inflating bag and 22.3 mL (8.8) for the T-piece in the non-instructor group. Higher inspiratory time values were observed with the T-piece in both groups of professionals, with no significant difference between them. The operator's ability to maintain the target pressure over the 10 seconds of sustained lung inflation was evaluated using the area under the pressure-time curve and was 1.7-fold higher with the use of the T-piece. Inspiratory pressure and mean airway pressure applied during sustained lung inflation were greater with the self-inflating bag, as evaluated between the beginning and the end of the procedure. The T-piece resulted in lower tidal volume and higher inspiratory time values, irrespective of the operator's experience, and increased the ease of performing the sustained lung inflation maneuver, as demonstrated by the maintenance of target pressure for the desired period and a higher mean airway pressure than that obtained using the self-inflating bag.

  3. Sustained versus intermittent lung inflation for resuscitation of preterm infants: a randomized controlled trial.

    Science.gov (United States)

    El-Chimi, Mohamed S; Awad, Hisham A; El-Gammasy, Tarek M; El-Farghali, Ola G; Sallam, Mohamed T; Shinkar, Dina M

    2017-06-01

    To evaluate efficacy and safety of delivery room (DR) sustained lung inflation (SLI) in resuscitation of preterm neonates. Randomized Controlled Trial including 112 preterm infants randomized to either SLI (n = 57) using T-piece resuscitator [maximum three inflations with maximum pressure of 30 cmH2O for 15 s followed by continuous positive airway pressure (CPAP) of 5-7 cmH2O] or conventional bag/mask inflation (CBMI) (n = 55) using traditional self-inflating bag (maximum pressure of 40 cmH2O at a rate of 40-60 per min). Failure was defined as the need for DR or first 72 h intubation. Cord and 2-h post-resuscitation blood samples were collected to measure interleukin (IL)-1β and tumor necrosis factor-α levels before and after intervention. SLI was associated with significantly higher success rate compared to CBMI [75.4 versus 54.5%; p = 0.017], lower need for DR intubation [5.3% versus 23.6%; (X(2 )=( )7.7; p = 0.005)], higher 5-min-Apgar score (median 8 versus 7; p = 0.018), shorter duration on nasal-CPAP (p = 0.017), and non-significantly different air leak (7% versus 11%; p = 0.3) and bronchopulmonary dysplasia rates among survivors (2% versus 11%; p = 0.09). Post-resuscitation IL-1β plasma levels increased significantly in CBMI (p = 0.009) and not in SLI group. Delivery room SLI is more effective than intermittent bag and mask inflation for improving short-term respiratory outcome in preterm infants, without significant adverse effects.

  4. Manual Ventilation and Sustained Lung Inflation in an Experimental Model: Influence of Equipment Type and Operator's Training.

    Directory of Open Access Journals (Sweden)

    Cristiane do Prado

    Full Text Available To compare the influence of devices for manual ventilation and individual experience on the applied respiratory mechanics and sustained lung inflation.A total of 114 instructors and non-instructors from the Neonatal Resuscitation Program of the Brazilian Society of Pediatrics participated in this study. Participants ventilated an intubated manikin. To evaluate respiratory mechanics and sustained lung inflation parameters, a direct comparison was made between the self-inflating bag and the T-shaped resuscitator (T-piece, followed by an analysis of the effectiveness of the equipment according to the participants' education and training.A difference between equipment types was observed for the tidal volume, with a median (interquartile range of 28.5 mL (12.6 for the self-inflating bag and 20.1 mL (8.4 for the T-piece in the instructor group and 31.6 mL (14 for the self-inflating bag and 22.3 mL (8.8 for the T-piece in the non-instructor group. Higher inspiratory time values were observed with the T-piece in both groups of professionals, with no significant difference between them. The operator's ability to maintain the target pressure over the 10 seconds of sustained lung inflation was evaluated using the area under the pressure-time curve and was 1.7-fold higher with the use of the T-piece. Inspiratory pressure and mean airway pressure applied during sustained lung inflation were greater with the self-inflating bag, as evaluated between the beginning and the end of the procedure.The T-piece resulted in lower tidal volume and higher inspiratory time values, irrespective of the operator's experience, and increased the ease of performing the sustained lung inflation maneuver, as demonstrated by the maintenance of target pressure for the desired period and a higher mean airway pressure than that obtained using the self-inflating bag.

  5. Manual Ventilation and Sustained Lung Inflation in an Experimental Model: Influence of Equipment Type and Operator’s Training

    Science.gov (United States)

    Mascaretti, Renata Suman; Vale, Luciana Assis; Haddad, Luciana Branco

    2016-01-01

    Aim To compare the influence of devices for manual ventilation and individual experience on the applied respiratory mechanics and sustained lung inflation. Methods A total of 114 instructors and non-instructors from the Neonatal Resuscitation Program of the Brazilian Society of Pediatrics participated in this study. Participants ventilated an intubated manikin. To evaluate respiratory mechanics and sustained lung inflation parameters, a direct comparison was made between the self-inflating bag and the T-shaped resuscitator (T-piece), followed by an analysis of the effectiveness of the equipment according to the participants’ education and training. Results A difference between equipment types was observed for the tidal volume, with a median (interquartile range) of 28.5 mL (12.6) for the self-inflating bag and 20.1 mL (8.4) for the T-piece in the instructor group and 31.6 mL (14) for the self-inflating bag and 22.3 mL (8.8) for the T-piece in the non-instructor group. Higher inspiratory time values were observed with the T-piece in both groups of professionals, with no significant difference between them. The operator’s ability to maintain the target pressure over the 10 seconds of sustained lung inflation was evaluated using the area under the pressure-time curve and was 1.7-fold higher with the use of the T-piece. Inspiratory pressure and mean airway pressure applied during sustained lung inflation were greater with the self-inflating bag, as evaluated between the beginning and the end of the procedure. Conclusion The T-piece resulted in lower tidal volume and higher inspiratory time values, irrespective of the operator’s experience, and increased the ease of performing the sustained lung inflation maneuver, as demonstrated by the maintenance of target pressure for the desired period and a higher mean airway pressure than that obtained using the self-inflating bag. PMID:26859896

  6. Sustained Inflation at Birth Did Not Alter Lung Injury from Mechanical Ventilation in Surfactant-Treated Fetal Lambs

    Science.gov (United States)

    Hillman, Noah H.; Kemp, Matthew W.; Miura, Yuichiro; Kallapur, Suhas G.; Jobe, Alan H.

    2014-01-01

    Background Sustained inflations (SI) are used with the initiation of ventilation at birth to rapidly recruit functional residual capacity and may decrease lung injury and the need for mechanical ventilation in preterm infants. However, a 20 second SI in surfactant-deficient preterm lambs caused an acute phase injury response without decreasing lung injury from subsequent mechanical ventilation. Hypothesis A 20 second SI at birth will decrease lung injury from mechanical ventilation in surfactant-treated preterm fetal lambs. Methods The head and chest of fetal sheep at 126±1 day GA were exteriorized, with tracheostomy and removal of fetal lung fluid prior to treatment with surfactant (300 mg in 15 ml saline). Fetal lambs were randomized to one of four 15 minute interventions: 1) PEEP 8 cmH2O; 2) 20 sec SI at 40 cmH2O, then PEEP 8 cmH2O; 3) mechanical ventilation with 7 ml/kg tidal volume; or 4) 20 sec SI then mechanical ventilation at 7 ml/kg. Fetal lambs remained on placental support for the intervention and for 30 min after the intervention. Results SI recruited a mean volume of 6.8±0.8 mL/kg. SI did not alter respiratory physiology during mechanical ventilation. Heat shock protein (HSP) 70, HSP60, and total protein in lung fluid similarly increased in both ventilation groups. Modest pro-inflammatory cytokine and acute phase responses, with or without SI, were similar with ventilation. SI alone did not increase markers of injury. Conclusion In surfactant treated fetal lambs, a 20 sec SI did not alter ventilation physiology or markers of lung injury from mechanical ventilation. PMID:25419969

  7. Sustained inflations: comparing three neonatal resuscitation devices.

    Science.gov (United States)

    Klingenberg, Claus; Dawson, Jennifer A; Gerber, Angela; Kamlin, C Omar F; Davis, Peter G; Morley, Colin J

    2011-01-01

    Some national resuscitation guidelines advocate using sustained initial inflations (2-3 s) for babies requiring resuscitation. Inflation times ≥10 s have been used for preterm infants. This study examines the ability of operators of varying experience to provide a sustained inflation using three different manual ventilation devices. We compared a self-inflating bag, a flow-inflating bag and a pressure-limited T-piece device. Fifty clinical staff members from five professional groups gave a sustained inflation with a target peak pressure of 30 cm H2O and target duration of 10 s to an internal leak-free manikin. We measured peak inflating pressure (PIP) and mean inflating pressure (MIP) during the sustained inflation, and the duration of inflating pressure (IP) >20 and 25 cm H2O. Median (IQR) duration of IP >25 cm H2O was: self-inflating bag 2.5 s (0.8-5.7), flow-inflating bag 10.6 s (8.4-12.9) and the T-piece 10.7 s (8.9-11.9). There was a weak correlation between experience using a self-inflating bag and longer inflation times (R = 0.290, p = 0.041). When compared with the T-piece, the flow-inflating bag had lower mean MIP (27.0 ± 1.8 vs. 28.8 ± 2.0 cm H2O) and higher mean PIP (32.3 ± 3.7 vs. 29.8 ± 1.8 cm H2O). There were no differences in performance between operator groups. The T-piece provided consistent PIP during a single 10 s sustained inflation with less variation in pressure compared with the flow-inflating bag. Sustained inflations >3 s were difficult to achieve with a self-inflating bag. Copyright © 2011 S. Karger AG, Basel.

  8. Lung Density Changes With Growth and Inflation

    Science.gov (United States)

    Kirk, Gregory; Drummond, M. Bradley; Mitzner, Wayne

    2015-01-01

    BACKGROUND: With body growth from childhood, the lungs can enlarge by either increasing the volume of air in the periphery (as would occur with inspiration) or by increasing the number of peripheral acinar units. In the former case, the lung tissue density would decrease with inflation, whereas in the latter case, the lung density would be relatively constant as the lung grows. To address this fundamental structural issue, we measured the CT scan density in human subjects of widely varying size at two different lung volumes. METHODS: Five hundred one subjects were enrolled in the study. They underwent a chest CT scan at full inspiration and another scan at end expiration. Spirometry, body plethysmography, and diffusing capacity of the lung for carbon monoxide were also measured. RESULTS: There was a strong correlation between the size of the lungs measured at full inspiration on CT scan and the mean lung density (r = −0.72, P = .001). People with larger lungs had significantly lower mean lung density. These density changes among different subjects overlapped the density changes within subjects at different lung volumes. CONCLUSIONS: Lung structure in subjects with larger lungs is different from that in subjects with smaller lungs. Tissue volume does not increase in proportion to lung size, as would be required if larger lungs just had more alveoli. These observations suggest that the growth of the lung into adulthood is not accompanied by new alveoli, but rather by enlargement of existing structures. The presence of greater air spaces in larger lungs could impact the occurrence and pathogenesis of spontaneous pneumothorax or COPD. PMID:25996948

  9. Avalanches and power-law behaviour in lung inflation

    Science.gov (United States)

    Suki, Béla; Barabási, Albert-László; Hantos, Zoltán; Peták, Ferenc; Stanley, H. Eugene

    1994-04-01

    WHEN lungs are emptied during exhalation, peripheral airways close up1. For people with lung disease, they may not reopen for a significant portion of inhalation, impairing gas exchange2,3. A knowledge of the mechanisms that govern reinflation of collapsed regions of lungs is therefore central to the development of ventilation strategies for combating respiratory problems. Here we report measurements of the terminal airway resistance, Rt , during the opening of isolated dog lungs. When inflated by a constant flow, Rt decreases in discrete jumps. We find that the probability distribution of the sizes of the jumps and of the time intervals between them exhibit power-law behaviour over two decades. We develop a model of the inflation process in which 'avalanches' of airway openings are seen-with power-law distributions of both the size of avalanches and the time intervals between them-which agree quantitatively with those seen experimentally, and are reminiscent of the power-law behaviour observed for self-organized critical systems4. Thus power-law distributions, arising from avalanches associated with threshold phenomena propagating down a branching tree structure, appear to govern the recruitment of terminal airspaces.

  10. Airway distensibility and volume recruitment with lung inflation in COPD.

    Science.gov (United States)

    Baldi, Simonetta; Dellacà, Raffaele; Govoni, Leonardo; Torchio, Roberto; Aliverti, Andrea; Pompilio, Pasquale; Corda, Luciano; Tantucci, Claudio; Gulotta, Carlo; Brusasco, Vito; Pellegrino, Riccardo

    2010-10-01

    The effects of full lung inflation on respiratory conductance (Grs) and reactance (Xrs) were measured in 15 subjects with moderate to severe chronic obstructive pulmonary disease (COPD) and 11 matched healthy control subjects. Airway distensibility was estimated from the ratio of the difference of Grs between functional residual capacity and total lung capacity to the relevant changes in lung volume (ΔGrs/ΔVl) or transpulmonary pressure (ΔGrs/ΔPtp). Similar analysis was applied to Xrs to estimate lung volume recruitment (ΔXrs/ΔVl or ΔXrs/ΔPtp). The extent of emphysema in COPD subjects was estimated from the percentage of low attenuation area (LAA) at high-resolution computed tomography. At baseline, ΔGrs/ΔVl and ΔXrs/ΔVl were significantly less in COPD than control subjects, indicating less distensibility and volume recruitment in the former. In COPD, ΔGrs/ΔPtp and ΔXrs/ΔPtp were uncorrelated with LAA but correlated with 1-s forced expiratory volume and with each other. After albuterol, both ΔGrs/ΔPtp and ΔGrs/ΔVl became significantly and negatively correlated with LAA, while ΔXrs/ΔPtp and ΔXrs/ΔVl decreased significantly independently of LAA. Moreover, ΔGrs/ΔPtp and ΔXrs/ΔPtp with lung inflation were no longer correlated with each other, suggesting that airway distensibility and volume recruitment were affected differently by airway smooth muscle tone. Assuming that Grs mainly reflects airway caliber and Xrs the number of ventilated lung units, we conclude that airway smooth muscle contributes to airway stiffness and ventilation inhomogeneities in COPD subjects with prevailing bronchitis but only to the latter in those with more emphysema. We suggest that changes of airway distensibility and volume recruitment with a bronchodilator may be useful for disease phenotyping.

  11. Self-inflating bags versus T-piece resuscitator to deliver sustained inflations in a preterm lamb model.

    Science.gov (United States)

    Thio, M; Dawson, J A; Moss, T J; Galinsky, R; Rafferty, A; Hooper, S B; Davis, P G

    2014-07-01

    In neonatal resuscitation, the use of a sustained inflation (SI) may facilitate lung aeration. Previous studies comparing different resuscitation devices have shown that one model of self-inflating bag (SIB) could not deliver an SI. We aimed to compare the delivery of an SI using four SIBs with that of a T-piece. In intubated preterm lambs, we compared four models of SIB fitted with a positive end expiratory pressure (PEEP) valve to a T-piece using a gas flow of 8 L/min. Four operators aimed to deliver three SIs of 20 cm H₂O for 30 s. The study was repeated with the PEEP valve removed and again with no flow. We measured duration of SI, average inflation pressure (IP) and analysed the shape of the pressure curves. 204 combinations were analysed. Mean (SD) duration of SI was Ambu 6(2)s, Laerdal 14(8)s, Parker Healthcare 5(1)s, Mayo Healthcare 33(2)s and T-piece 33(1)s. Mean (SD) average IP was Ambu 17(3)cm H₂O, Laerdal 17(3)cm H₂O, Parker Healthcare 12(5)cm H₂O, Mayo Healthcare 21(2)cm H₂O and T-piece 20(0)cm H₂O. Duration of SI and average IP was significantly different between SIBs (all p0.05). Only the Mayo system delivered SIs with duration and average IP not significantly different from the T-piece (p>0.05). The performance of the four SIBs tested varied considerably. Some are able to deliver an SI even in the absence of gas flow. This may be useful in a resource-limited setting with no gas supply.

  12. Static inflation attenuates ischemia/reperfusion injury in an isolated rat lung in situ.

    Science.gov (United States)

    Kao, Shang Jyh; Wang, David; Yeh, Diana Yu-Wung; Hsu, Kang; Hsu, Yung Hsiang; Chen, Hsing I

    2004-08-01

    Ischemia (I)/reperfusion (R) lung injury is an important clinical issue in lung transplantation. In the present study, we observed the effects of lung static inflation, different perfusates, and ventilatory gas with nitrogen or oxygen on the I/R-induced pulmonary damage. A total of 96 male Sprague-Dawley rats were used. The lung was isolated in situ. In an isolated lung, the capillary filtration coefficient (Kfc), lung weight gain (LWG), lung weight (LW)/body weight (BW) ratio, and protein concentration in BAL fluid (PCBAL) were measured or calculated to evaluate the degree of lung injury. Histologic examinations with hematoxylin-eosin staining were performed. I/R caused lung injury, as reflected by increases in Kfc, LWG, LW/BW, and PCBAL. The histopathologic picture revealed the presence of hyaline membrane formation and the infiltration of inflammatory cells. These values were significantly attenuated by static lung inflation. The I/R lung damage appeared to be less in the lung perfused with whole blood than in the lung perfused with an isotonic solution. Therapy with ventilatory air (ie, nitrogen or oxygen) did not alter the I/R lung damage. The data suggest that lung inflation is protective to I/R injury, irrespective of the type of ventilatory air used for treatment. The preservation of the lung for transplantation is better kept at a static inflation state and perfused with whole blood instead of an isotonic physiologic solution.

  13. Acute lung injury: effects of prone positioning on cephalocaudal distribution of lung inflation--CT assessment in dogs.

    Science.gov (United States)

    Lee, Hyun Ju; Im, Jung-Gi; Goo, Jin Mo; Kim, Young Il; Lee, Min Woo; Ryu, Ho-Geol; Bahk, Jae-Hyon; Yoo, Chul-Gyu

    2005-01-01

    To quantify cephalocaudal gradient of lung inflation in acute lung injury in a dog model in prone versus supine position. Experiments were performed in accordance with Guide for the Care and Use of Laboratory Animals, as approved by National Research Council (National Institutes of Health), and were approved by committee on care and use of animals in research at Seoul National University Hospital. After induction of acute lung injury with intravenous injection of oleic acid, dogs were randomized to be ventilated in either prone (n = 6) or supine (n = 6) position. Spiral computed tomography (CT) and hemodynamic measurement were performed sequentially on an hourly basis. Volume and mean attenuation of lung were measured quantitatively by using software to evaluate each CT section. Cephalocaudal gradient of mean lung attenuation, distribution of gas and tissue, and alveolar expansion were assessed. Functional residual capacity and net alveolar expansion of entire lung were measured. Statistical analysis was performed with Friedman, sign, and Mann-Whitney tests. Mean lung attenuation increased gradually from apex to base of lung in supine position. Thus, inflation gradient along cephalocaudal axis was found. Gas was located predominantly in upper lung, whereas tissue was dominant in lower lung in supine position. In supine group, cephalocaudal inflation gradient showed no significant change from baseline up to 4 hours. After prone positioning, cephalocaudal inflation gradient was reduced, and gas and tissue proportions became more uniform along cephalocaudal axis. In prone group, absolute values of cephalocaudal inflation gradient at time points of prone positioning for 1, 2, and 3 hours were significantly lower than baseline values (P lung was not altered significantly. Functional residual capacity was unchanged by prone positioning. In acute lung injury, prone positioning induced more uniform distribution of gas and tissue along cephalocaudal axis by reducing

  14. Inflation

    Science.gov (United States)

    Baumann, Daniel

    2011-03-01

    In a series of five lectures I review inflationary cosmology. I begin with a description of the initial conditions problems of the Friedmann-Robertson-Walker (FRW) cosmology and then explain how inflation, an early period of accelerated expansion, solves these problems. Next, I describe how inflation transforms microscopic quantum fluctuations into macroscopic seeds for cosmological structure formation. I present in full detail the famous calculation for the primordial spectra of scalar and tensor fluctuations. I then define the inverse problem of extracting information on the inflationary era from observations of cosmic microwave background fluctuations. The current observational evidence for inflation and opportunities for future tests of inflation are discussed. Finally, I review the challenge of relating inflation to fundamental physics by giving an account of inflation in string theory.

  15. Surfactant before the first inflation at birth improves spatial distribution of ventilation and reduces lung injury in preterm lambs.

    Science.gov (United States)

    Tingay, David G; Wallace, Megan J; Bhatia, Risha; Schmölzer, Georg M; Zahra, Valerie A; Dolan, Melinda J; Hooper, Stuart B; Davis, Peter G

    2014-02-01

    The interrelationship between the role of surfactant and a sustained inflation (SI) to aid ex utero transition of the preterm lung is unknown. We compared the effect of surfactant administered before and after an initial SI on gas exchange, lung mechanics, spatial distribution of ventilation, and lung injury in preterm lambs. Gestational-age lambs (127 days; 9 per group) received 100 mg/kg of a surfactant (Curosurf) either prior (Surf+SI) or 10 min after birth (SI+Surf). At birth, a 20-s, 35 cmH2O SI was applied, followed by 70 min of positive pressure ventilation. Oxygenation, carbon dioxide removal, respiratory system compliance, end-expiratory thoracic volume (via respiratory inductive plethysmography), and distribution of end-expiratory volume and ventilation (via electrical impedance tomography) were measured throughout. Early markers of lung injury were analyzed using quantitative RT-PCR. During the first 15 min, oxygenation, carbon dioxide removal, and compliance were better in the Surf+SI group (all P ventilation was more uniform in the Surf+SI group throughout; 50.1 ± 10.9% of total ventilation in the left hemithorax at 70 min vs. 42.6 ± 11.1% in the SI+Surf group. Surf+SI resulted in lower mRNA levels of CYR61 and EGR1 compared with SI+Surf (P mechanical and injury response to a sustained inflation and ventilation by changing surface tension of the air/fluid interface.

  16. Mechanism of the lung-deflating action of the canine diaphragm at extreme lung inflation.

    Science.gov (United States)

    Leduc, Dimitri; Cappello, Matteo; Gevenois, Pierre Alain; De Troyer, André

    2012-04-01

    When lung volume in animals is passively increased beyond total lung capacity (TLC; transrespiratory pressure = +30 cmH(2)O), stimulation of the phrenic nerves causes a rise, rather than a fall, in pleural pressure. It has been suggested that this was the result of inward displacement of the lower ribs, but the mechanism is uncertain. In the present study, radiopaque markers were attached to muscle bundles in the midcostal region of the diaphragm and to the tenth rib pair in five dogs, and computed tomography was used to measure the displacement, length, and configuration of the muscle and the displacement of the lower ribs during relaxation at seven different lung volumes up to +60 cmH(2)O transrespiratory pressure and during phrenic nerve stimulation at the same lung volumes. The data showed that 1) during phrenic nerve stimulation at 60 cmH(2)O, airway opening pressure increased by 1.5 ± 0.7 cmH(2)O; 2) the dome of the diaphragm and the lower ribs were essentially stationary during such stimulation, but the muscle fibers still shortened significantly; 3) with passive inflation beyond TLC, an area with a cranial concavity appeared at the periphery of the costal portion of the diaphragm, forming a groove along the ventral third of the rib cage; and 4) this area decreased markedly in size or disappeared during phrenic stimulation. It is concluded that the lung-deflating action of the isolated diaphragm beyond TLC is primarily related to the invaginations in the muscle caused by the acute margins of the lower lung lobes. These findings also suggest that the inspiratory inward displacement of the lower ribs commonly observed in patients with emphysema (Hoover's sign) requires not only a marked hyperinflation but also a large fall in pleural pressure.

  17. A model of the recruitment-derecruitment and volume of lung units in an excised lung as it is inflated-deflated between minimum and maximum lung volume.

    Science.gov (United States)

    Frazer, D G; Lindsley, W G; McKinney, W; Reynolds, J S; Franz, G N; Jackson, M; Goldsmith, W T

    2013-03-01

    The role of the recruitment-derecruitment of small structures in the lung (lung units) as the lung increases and decreases in volume has been debated. The objective of this study was to develop a model to estimate the change in the number and volume of open lung units as an excised lung is inflated-deflated between minimum and maximum lung volume. The model was formulated based on the observation that the compliance of the slowly changing quasi-static pressure-volume (P-V) curve of an excised rat lung can differ from the compliance of a faster changing small sinusoidal pressure volume perturbations superimposed on the curve. In those regions of the curve where differences in compliance occur, the lung tissue properties exhibit nonlinear characteristics, which cannot be linearized using "incremental" or "small signal" analysis. The model attributes the differences between the perturbation and quasi-static compliance to an additional nonlinear compliance term that results from the sequential opening and closing of lung units. Using this approach, it was possible to calculate the normalized average volume and the normalized number of open units as the lung is slowly inflated-deflated. Results indicate that the normalized average volume and the normalized number of open units are not linearly related to normalized lung volume, and at equal lung volumes the normalized number of open units is greater and the normalized average lung unit volume is smaller during lung deflation when compared to lung inflation. In summary, a model was developed to describe the recruitment-derecruitment process in excised lungs based on the differences between small signal perturbation compliance and quasi-static compliance. Values of normalized lung unit volume and the normalized number of open lung units were shown to be nonlinear functions of both transpulmonary pressure and normalized lung volume.

  18. Inflation Pressures for Ex Vivo Lung Biopsies After Application of Graduated Compression Staples.

    Science.gov (United States)

    Imhoff, Darren J; Monnet, Eric

    2016-01-01

    To compare 2 graduated compression staples (Tri-Staple™, Covidien, Norwalk, CT) and standard staples (Endo GIA™, Covidien) for lung biopsy in dogs. Ex vivo experimental study, randomized, unblocked. Lung lobes (n = 18) from 4 canine cadavers. Eighteen lung lobes were harvested from 4 dogs immediately after euthanasia and randomized to 1 of 3 staples (n = 6 per stapler type). Each lung lobe was intubated and maintained inflated at 10 cmH2O. A biopsy of the periphery of each lung lobe was taken approximately 3 cm from the edge with a stapling device; the Tri-Staple™ medium/thick (TST), Tri-Staple™ vascular/medium (TSV), and Endo GIA™ 45-2.5 (EG). Each lobe was inflated to a maximum of 45 cmH2O of water to determine the pressure at which air leakage occurred (leak pressure). The mean (95% confidence interval) leak pressure was 38.0 cmH2O (33.1-42.9) for EG, 29.2 (24.3-34.0) for TSV, and 26.0 (21.1-30.9) for TST. The mean leak pressure was significantly higher for EG than TSV (P = .016) and for EG than TST (P = .002), but was not different between TSV and TST (P = .344). One TSV leaked at 20 cmH2O and 1 TST leaked at 17 cmH2O. The surface area of the biopsy samples was not significantly different for staple types (P = .183). Both TST and TSV leaked at significantly lower airway pressures than EG and may not be suitable for canine lung biopsy as some specimens leaked at pressures of 20 cmH2O or less. © Copyright 2015 by The American College of Veterinary Surgeons.

  19. Sustained inflation and incremental mean airway pressure trial during conventional and high-frequency oscillatory ventilation in a large porcine model of acute respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Wunder Christian

    2006-06-01

    Full Text Available Abstract Background To compare the effect of a sustained inflation followed by an incremental mean airway pressure trial during conventional and high-frequency oscillatory ventilation on oxygenation and hemodynamics in a large porcine model of early acute respiratory distress syndrome. Methods Severe lung injury (Ali was induced in 18 healthy pigs (55.3 ± 3.9 kg, mean ± SD by repeated saline lung lavage until PaO2 decreased to less than 60 mmHg. After a stabilisation period of 60 minutes, the animals were randomly assigned to two groups: Group 1 (Pressure controlled ventilation; PCV: FIO2 = 1.0, PEEP = 5 cmH2O, VT = 6 ml/kg, respiratory rate = 30/min, I:E = 1:1; group 2 (High-frequency oscillatory ventilation; HFOV: FIO2 = 1.0, Bias flow = 30 l/min, Amplitude = 60 cmH2O, Frequency = 6 Hz, I:E = 1:1. A sustained inflation (SI; 50 cmH2O for 60s followed by an incremental mean airway pressure (mPaw trial (steps of 3 cmH2O every 15 minutes were performed in both groups until PaO2 no longer increased. This was regarded as full lung inflation. The mPaw was decreased by 3 cmH2O and the animals reached the end of the study protocol. Gas exchange and hemodynamic data were collected at each step. Results The SI led to a significant improvement of the PaO2/FiO2-Index (HFOV: 200 ± 100 vs. PCV: 58 ± 15 and TAli: 57 ± 12; p 2-reduction (HFOV: 42 ± 5 vs. PCV: 62 ± 13 and TAli: 55 ± 9; p Ali: 6.1 ± 1 vs. T75: 3.4 ± 0.4; PCV: TAli: 6.7 ± 2.4 vs. T75: 4 ± 0.5; p Conclusion A sustained inflation followed by an incremental mean airway pressure trial in HFOV improved oxygenation at a lower mPaw than during conventional lung protective ventilation. HFOV but not PCV resulted in normocapnia, suggesting that during HFOV there are alternatives to tidal ventilation to achieve CO2-elimination in an "open lung" approach.

  20. Effect of Lung Inflation Level on Hyperpolarized 3He Apparent Diffusion Coefficient Measurements in Never-Smokers

    Science.gov (United States)

    Halaweish, Ahmed F.; Thedens, Daniel R.; Fuld, Matthew K.; Sieren, Jered P.; van Beek, Edwin J. R.

    2013-01-01

    Purpose: To evaluate the effects of lung volume differences on apparent diffusion coefficient (ADC) measurements on a regional basis, with breath holds at volumes adjusted for differences in lung size across individuals according to the subject’s vital capacity (VC). Materials and Methods: This study was approved by the local institutional review board and was compliant with HIPAA. Informed consent was obtained from all subjects. Imaging was performed under a physician’s Investigational New Drug application from the Food and Drug Administration. ADC changes as a function of inflation levels were evaluated in 24 healthy never-smokers across three lung volumes (20%, 60%, and 100% VC) on the basis of the spirometric data collected from each subject. Response variables based on lung volume and anatomic position were assessed with multifactorial analysis of variance followed by posthoc pair-wise testing. Imaging was performed with a 1.5-T magnetic resonance (MR) unit with use of a two-dimensional gradient-echo fast low-angle shot sequence. Results: Significant differences in ADCs between lung volumes were observed for all inflation levels (20%, 60%, and 100% VC; P lung only). In addition, significant differences between mean values in the left and right lungs with respect to those in the whole lung were observed at the lower lung inflation levels (20% and 60% VC, P lung volume changes, emphasizing the need for tight control over lung volume when performing hyperpolarized helium 3 (3He) lung studies if 3He MR imaging is to be used to follow up small longitudinal changes in lung abnormalities. © RSNA, 2013 PMID:23592768

  1. Sustained inflation versus positive pressure ventilation at birth: a systematic review and meta-analysis.

    Science.gov (United States)

    Schmölzer, Georg M; Kumar, Manoj; Aziz, Khalid; Pichler, Gerhard; O'Reilly, Megan; Lista, Gianluca; Cheung, Po-Yin

    2015-07-01

    Sustained inflation (SI) has been advocated as an alternative to intermittent positive pressure ventilation (IPPV) during the resuscitation of neonates at birth, to facilitate the early development of an effective functional residual capacity, reduce atelectotrauma and improve oxygenation after the birth of preterm infants. The primary aim was to review the available literature on the use of SI compared with IPPV at birth in preterm infants for major neonatal outcomes, including bronchopulmonary dysplasia (BPD) and death. MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials, until 6 October 2014. Randomised clinical trials comparing the effects of SI with IPPV at birth in preterm infants for neonatal outcomes. Descriptive and quantitative information was extracted; data were pooled using a random effects model. Heterogeneity was assessed using the Q statistic and I(2). Pooled analysis showed significant reduction in the need for mechanical ventilation within 72 h after birth (relative risk (RR) 0.87 (0.77 to 0.97), absolute risk reduction (ARR) -0.10 (-0.17 to -0.03), number needed to treat 10) in preterm infants treated with an initial SI compared with IPPV. However, significantly more infants treated with SI received treatment for patent ductus arteriosus (RR 1.27 (1.05 to 1.54), ARR 0.10 (0.03 to 0.16), number needed to harm 10). There were no differences in BPD, death at the latest follow-up and the combined outcome of death or BPD among survivors between the groups. Compared with IPPV, preterm infants initially treated with SI at birth required less mechanical ventilation with no improvement in the rate of BPD and/or death. The use of SI should be restricted to randomised trials until future studies demonstrate the efficacy and safety of this lung aeration manoeuvre. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  2. Static inflation and deflation pressure–volume curves from excised lungs of marine mammals

    Science.gov (United States)

    Fahlman, Andreas; Loring, Stephen H.; Ferrigno, Massimo; Moore, Colby; Early, Greg; Niemeyer, Misty; Lentell, Betty; Wenzel, Frederic; Joy, Ruth; Moore, Michael J.

    2011-01-01

    SUMMARY Excised lungs from eight marine mammal species [harp seal (Pagophilus groenlandicus), harbor seal (Phoca vitulina), gray seal (Halichoerus grypush), Atlantic white-sided dolphin (Lagenorhynchus acutus), common dolphin (Delphinus delphis), Risso's dolphin (Grampus griseus), long-finned pilot whale (Globicephala melas) and harbor porpoise (Phocoena phocoena)] were used to determine the minimum air volume of the relaxed lung (MAV, N=15), the elastic properties (pressure–volume curves, N=24) of the respiratory system and the total lung capacity (TLC). Our data indicate that mass-specific TLC (sTLC, l kg–1) does not differ between species or groups (odontocete vs phocid) and agree with that estimated (TLCest) from body mass (Mb) by applying the equation: TLCest=0.135 Mb0.92. Measured MAV was on average 7% of TLC, with a range from 0 to 16%. The pressure–volume curves were similar among species on inflation but diverged during deflation in phocids in comparison with odontocetes. These differences provide a structural basis for observed species differences in the depth at which lungs collapse and gas exchange ceases. PMID:22031747

  3. Static inflation and deflation pressure-volume curves from excised lungs of marine mammals.

    Science.gov (United States)

    Fahlman, Andreas; Loring, Stephen H; Ferrigno, Massimo; Moore, Colby; Early, Greg; Niemeyer, Misty; Lentell, Betty; Wenzel, Frederic; Joy, Ruth; Moore, Michael J

    2011-11-15

    Excised lungs from eight marine mammal species [harp seal (Pagophilus groenlandicus), harbor seal (Phoca vitulina), gray seal (Halichoerus grypush), Atlantic white-sided dolphin (Lagenorhynchus acutus), common dolphin (Delphinus delphis), Risso's dolphin (Grampus griseus), long-finned pilot whale (Globicephala melas) and harbor porpoise (Phocoena phocoena)] were used to determine the minimum air volume of the relaxed lung (MAV, N=15), the elastic properties (pressure-volume curves, N=24) of the respiratory system and the total lung capacity (TLC). Our data indicate that mass-specific TLC (sTLC, l kg(-1)) does not differ between species or groups (odontocete vs phocid) and agree with that estimated (TLC(est)) from body mass (M(b)) by applying the equation: TLC(est)=0.135 M(b)(0.92). Measured MAV was on average 7% of TLC, with a range from 0 to 16%. The pressure-volume curves were similar among species on inflation but diverged during deflation in phocids in comparison with odontocetes. These differences provide a structural basis for observed species differences in the depth at which lungs collapse and gas exchange ceases.

  4. Effect of parenchymal stiffness on canine airway size with lung inflation.

    Directory of Open Access Journals (Sweden)

    Robert H Brown

    2010-04-01

    Full Text Available Although airway patency is partially maintained by parenchymal tethering, this structural support is often ignored in many discussions of asthma. However, agonists that induce smooth muscle contraction also stiffen the parenchyma, so such parenchymal stiffening may serve as a defense mechanism to prevent airway narrowing or closure. To quantify this effect, specifically how changes in parenchymal stiffness alter airway size at different levels of lung inflation, in the present study, we devised a method to separate the effect of parenchymal stiffening from that of direct airway narrowing. Six anesthetized dogs were studied under four conditions: baseline, after whole lung aerosol histamine challenge, after local airway histamine challenge, and after complete relaxation of the airways. In each of these conditions, we used High resolution Computed Tomography to measure airway size and lung volume at five different airway pressures (0, 12, 25, 32, and 45 cm H(2O. Parenchymal stiffening had a protective effect on airway narrowing, a fact that may be important in the airway response to deep inspiration in asthma. When the parenchyma was stiffened by whole lung aerosol histamine challenge, at every lung volume above FRC, the airways were larger than when they were directly challenged with histamine to the same initial constriction. These results show for the first time that a stiff parenchyma per se minimizes the airway narrowing that occurs with histamine challenge at any lung volume. Thus in clinical asthma, it is not simply increased airway smooth muscle contraction, but perhaps a lack of homogeneous parenchymal stiffening that contributes to the symptomatic airway hyperresponsiveness.

  5. Electrical impedance tomography compared with thoracic computed tomography during a slow inflation maneuver in experimental models of lung injury.

    Science.gov (United States)

    Wrigge, Hermann; Zinserling, Jörg; Muders, Thomas; Varelmann, Dirk; Günther, Ulf; von der Groeben, Cornelius; Magnusson, Anders; Hedenstierna, Göran; Putensen, Christian

    2008-03-01

    To determine the validity of functional electric impedance tomography to monitor regional ventilation distribution in experimental acute lung injury, and to develop a simple electric impedance tomography index detecting alveolar recruitment. Randomized prospective experimental study. Academic research laboratory. Sixteen anesthetized, tracheotomized, and mechanically ventilated pigs. Acute lung injury was induced either by acid aspiration (direct acute lung injury) or by abdominal hypertension plus oleic acid injection (indirect acute lung injury) in ten pigs. Six pigs with normal lungs were studied as a control group and with endotracheal suction-related atelectasis. After 4 hrs of mechanical ventilation, a slow inflation was performed. During slow inflation, simultaneous measurements of regional ventilation by electric impedance tomography and dynamic computed tomography were highly correlated in quadrants of a transversal thoracic plane (r2 = .63-.88, p Electric impedance tomography indexes to detect alveolar recruitment were determined by mathematical curve analysis of regional impedance time curves. Empirical tests of different methods revealed that regional ventilation delay, that is, time delay of regional impedance time curve to reach a threshold, correlated well with recruited volume as measured by CT (r2 = .63). Correlation coefficients in subgroups were r2 = .71 and r2 = .48 in pigs with normal lungs with and without closed suction related atelectasis and r2 = .79 in pigs subject to indirect acute lung injury, respectively, whereas no significant correlation was found in pigs undergoing direct acute lung injury. Electric impedance tomography allows assessment of regional ventilation distribution and recruitment in experimental models of direct and indirect acute lung injury as well as normal lungs. Except for pigs with direct acute lung injury, regional ventilation delay determined during a slow inflation from impedance time curves appears to be a simple

  6. The role of lung inflation and sodium transport in airway liquid clearance during lung aeration in newborn rabbits.

    Science.gov (United States)

    Siew, Melissa L; Wallace, Megan J; Allison, Beth J; Kitchen, Marcus J; te Pas, Arjan B; Islam, M Sirajul; Lewis, Robert A; Fouras, Andreas; Yagi, Naoto; Uesugi, Kentaro; Hooper, Stuart B

    2013-04-01

    Recent phase-contrast X-ray imaging studies suggest that inspiration primarily drives lung aeration and airway liquid clearance at birth, which questions the role of adrenaline-induced activation of epithelial sodium channels (ENaCs). We hypothesized that pressures generated by inspiration have a greater role in airway liquid clearance than do ENaCs after birth. Rabbit pups (30 d of gestation) were delivered and sedated, and 0.1 ml of saline (S) or amiloride (Am; an ENaC inhibitor) was instilled into the lungs before mechanical ventilation. Two other groups (30 d of gestation) were treated similarly but were also given adrenaline (S/Ad and Am/Ad) before mechanical ventilation. Amiloride and adrenaline did not affect functional residual capacity (FRC) recruitment (P > 0.05). Amiloride increased the rate of FRC loss between inflations (Am: -5.2 ± 0.6 ml/kg/s), whereas adrenaline reduced the rate of FRC loss (S/Ad: -1.9 ± 0.3 ml/kg/s) as compared with saline-treated controls (S: -3.5 ± -0.6 ml/kg/s; P < 0.05). These data indicate that inspiration is a major determinant of airway liquid clearance and FRC development during positive pressure ventilation. Although ENaC inhibition and adrenaline administration had no detectable effect on FRC development, ENaC may help to prevent liquid from re-entering the airways during expiration.

  7. Demonstration of pulmonary perfusion heterogeneity induced by gravity and lung inflation using arterial spin labeling.

    Science.gov (United States)

    Fan, Li; Liu, Shi-Yuan; Xiao, Xiang-Sheng; Sun, Fei

    2010-02-01

    To evaluate the effect of gravity and lung inflation on pulmonary perfusion heterogeneity in human lung using an arterial spin labeling (ASL) sequence called flow sensitive alternating inversion recovery (FAIR). Magnetic resonance imaging of lung perfusion using arterial spin labeling sequence was performed in supine position in ten healthy volunteers on a 1.5T whole body scanner (GE Healthcare). Five coronal slices at an interval of 3cm from dorsal to ventral (labeled as P3, P6, P9, P12, P15, sequently) were obtained when the volunteers performed breath holding on end expiration and the relative pulmonary blood flow (rPBF) was measured. Then, another coronal perfusion-weighted image of P3 slice was obtained on end inspiration. Tagging efficiency of pulmonary parenchyma with IR (DeltaSI), rPBF and area of the P3 slice were analyzed. (1) Along the direction of gravity, a gradient was visually perceived as a vertical increase in rPBF. There were significant statistic differences in rPBF between any two coronal planes except that between P12 and P15. In supine position, regression coefficients of right and left lung were -4.98 and -5.16, respectively. This means that rPBF decreased 4.98 (right) and 5.16 (left) for each centimeter above the dorsal. No statistical difference was seen between ROIs placed along iso-gravitational plane. (2) For a same slice, there were significant statistic differences in DeltaSI, rPBF and area at different respiratory phases (P<0.05). Greater DeltaSI and more perfusion were observed on end expiration than on end inspiration. The area was larger on end inspiration than on end expiration. Both gravity and respiratory phase are important determinants of pulmonary perfusion heterogeneity. FAIR is sensitive to demonstrate gravity- and respiratory phase-dependent differences in lung perfusion. Positioning the patient so that the area of interest is down-gravity and asking patient to hold breath on end expiration may help in detection of

  8. Multiphoton microscopy based cryo-imaging of inflated frozen human lung sections at -60°C in healthy and COPD lungs

    Science.gov (United States)

    Abraham, Thomas; Kayra, Damian; Zhang, Angela; Suzuki, Masaru; McDonough, John; Elliott, W. M.; Cooper, Joel D.; Hogg, James C.

    2013-02-01

    Lung is a complex gas exchanger with interfacial area (where the gas exchange takes place) is about the size of a tennis court. Respiratory function is linked to the biomechanical stability of the gas exchange or alveolar regions which directly depends on the spatial distributions of the extracellular matrix fibers such fibrillar collagens and elastin fibers. It is very important to visualize and quantify these fibers at their native and inflated conditions to have correct morphometric information on differences between control and diseased states. This can be only achieved in the ex vivo states by imaging directly frozen lung specimens inflated to total lung capacity. Multiphoton microscopy, which uses ultra-short infrared laser pulses as the excitation source, produces multiphoton excitation fluorescence (MPEF) signals from endogenously fluorescent proteins (e.g. elastin) and induces specific second harmonic generation (SHG) signals from non-centrosymmetric proteins such as fibrillar collagens in fresh human lung tissues [J. Struct. Biol. (2010)171,189-196]. Here we report for the first time 3D image data obtained directly from thick frozen inflated lung specimens (~0.7- 1.0 millimeter thick) visualized at -60°C without prior fixation or staining in healthy and diseased states. Lung specimens donated for transplantation and released for research when no appropriate recipient was identified served as controls, and diseased lung specimens donated for research by patients receiving lung transplantation for very severe COPD (n=4) were prepared as previously described [N. Engl. J. Med. (2011) 201, 1567]. Lung slices evenly spaced between apex and base were examined using multiphoton microscopy while maintained at -60°C using a temperature controlled cold stage with a temperature resolution of 0.1°C. Infrared femto-second laser pulses tuned to 880nm, dry microscopic objectives, and non-de-scanned detectors/spectrophotometer located in the reflection geometry were

  9. Global and regional assessment of sustained inflation pressure-volume curves in patients with acute respiratory distress syndrome.

    Science.gov (United States)

    Becher, T; Rostalski, P; Kott, M; Adler, A; Schädler, D; Weiler, N; Frerichs, I

    2017-06-01

    Static or quasi-static pressure-volume (P-V ) curves can be used to determine the lung mechanical properties of patients suffering from acute respiratory distress syndrome (ARDS). According to the traditional interpretation, lung recruitment occurs mainly below the lower point of maximum curvature (LPMC) of the inflation P-V curve. Although some studies have questioned this assumption, setting of positive end-expiratory pressure 2 cmH2O above the LPMC was part of a 'lung-protective' ventilation strategy successfully applied in several clinical trials. The aim of our study was to quantify the amount of unrecruited lung at different clinically relevant points of the P-V curve. P-V curves and electrical impedance tomography (EIT) data from 30 ARDS patients were analysed. We determined the regional opening pressures for every EIT image pixel and fitted the global P-V curves to five sigmoid model equations to determine the LPMC, inflection point (IP) and upper point of maximal curvature (UPMC). Points of maximal curvature and IP were compared between the models by one-way analysis of variance (ANOVA). The percentages of lung pixels remaining closed ('unrecruited lung') at LPMC, IP and UPMC were calculated from the number of lung pixels exhibiting regional opening pressures higher than LPMC, IP and UPMC and were also compared by one-way ANOVA. As results, we found a high variability of LPMC values among the models, a smaller variability of IP and UPMC values. We found a high percentage of unrecruited lung at LPMC, a small percentage of unrecruited lung at IP and no unrecruited lung at UPMC. Our results confirm the notion of ongoing lung recruitment at pressure levels above LPMC for all investigated model equations and highlight the importance of a regional assessment of lung recruitment in patients with ARDS.

  10. Association Between Airway Caliber Changes With Lung Inflation and Emphysema Assessed by Volumetric CT Scan in Subjects With COPD

    Science.gov (United States)

    Come, Carolyn E.; Ross, James C.; San José Estépar, Raúl; Han, MeiLan K.; Loring, Stephen H.; Silverman, Edwin K.; Washko, George R.

    2012-01-01

    Background: An increase in airway caliber (airway distensibility) with lung inflation is attenuated in COPD. Furthermore, some subjects have a decrease in airway caliber with lung inflation. We aimed to test the hypothesis that airway caliber increases are lower in subjects with emphysema-predominant (EP) compared with airway-predominant (AP) CT scan subtypes. Additionally, we compared clinical and CT scan features of subjects with (airway constrictors) and without a decrease in airway caliber. Methods: Based on GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages and CT scan subtypes, we created a control group (n = 46) and the following matched COPD groups (n = 23 each): GOLD-2-AP, GOLD-2-EP, GOLD-4-AP, and GOLD-4-EP. From the CT scans of all 138 subjects, we measured emphysema, lung volumes, and caliber changes in the third and fourth airway generations of two bronchi. We expressed airway distensibility (ratio of airway lumen diameter change to lung volume change from end tidal breathing to full inspiration) as a global or lobar measure based on normalization by whole-lung or lobar volume changes. Results: Global distensibility in the third and fourth airway generations was significantly lower in the GOLD-2-EP and GOLD-4-EP groups than in control subjects. In GOLD-2 subjects, lobar distensibility of the right-upper-lobe fourth airway generation was significantly lower in those with EP than in those with AP. In multivariate analysis, emphysema was an independent determinant of global and lobar airway distensibility. Compared with nonconstrictors, airway constrictors experienced more dyspnea, were more hyperinflated, and had a higher percentage of emphysema. Conclusions: Distensibility of large- to medium-sized airways is reduced in subjects with an EP CT scan subtype. Emphysema seems to alter airway-parenchyma interdependence. Trial registry: ClinicalTrials.gov; No.: NCT00608764; URL: www.clinicaltrials.gov PMID:21940776

  11. Inflation targeting and core inflation

    OpenAIRE

    Julie Smith

    2005-01-01

    This paper examines the interaction of core inflation and inflation targeting as a monetary policy regime. Interest in core inflation has grown because of inflation targeting. Core inflation is defined in numerous ways giving rise to many potential measures; this paper defines core inflation as the best forecaster of inflation. A cross-country study finds before the start of inflation targeting, but not after, core inflation differs between non-inflation targeters and inflation targeters. Thr...

  12. Sustained CD8+ T cell memory inflation after infection with a single-cycle cytomegalovirus.

    Directory of Open Access Journals (Sweden)

    Christopher M Snyder

    2011-10-01

    Full Text Available Cytomegalovirus (CMV is a β-herpesvirus that establishes a lifelong latent or persistent infection. A hallmark of chronic CMV infection is the lifelong persistence of large numbers of virus-specific CD8+ effector/effector memory T cells, a phenomenon called "memory inflation". How the virus continuously stimulates these T cells without being eradicated remains an enigma. The prevailing view is that CMV establishes a low grade "smoldering" infection characterized by tiny bursts of productive infection which are rapidly extinguished, leaving no detectable virus but replenishing the latent pool and leaving the immune system in a highly charged state. However, since abortive reactivation with limited viral gene expression is known to occur commonly, we investigated the necessity for virus reproduction in maintaining the inflationary T cell pool. We inhibited viral replication or spread in vivo using two different mutants of murine CMV (MCMV. First, famcyclovir blocked the replication of MCMV encoding the HSV Thymidine Kinase gene, but had no impact on the CD8+ T cell memory inflation once the infection was established. Second, MCMV that lacks the essential glycoprotein L, and thus is completely unable to spread from cell to cell, also drove memory inflation if the virus was administered systemically. Our data suggest that CMV which cannot spread from the cells it initially infects can repeatedly generate viral antigens to drive memory inflation without suffering eradication of the latent genome pool.

  13. Inflation and deflation pressure-volume loops in anesthetized pinnipeds confirms compliant chest and lungs

    Directory of Open Access Journals (Sweden)

    Andreas eFahlman

    2014-11-01

    Full Text Available We examined structural properties of the marine mammal respiratory system, and tested Scholander’s hypothesis that the chest is highly compliant by measuring the mechanical properties of the respiratory system in five species of pinniped under anesthesia (Pacific harbor seal, Phoca vitulina; northern elephant seal, Mirounga angustirostris; northern fur seal Callorhinus ursinus; California sea lion, Zalophus californianus; and Steller sea lion, Eumetopias jubatus. We found that the chest wall compliance (CCW of all five species was greater than lung compliance (airways and alveoli, CL as predicted by Scholander, which suggests that the chest provides little protection against alveolar collapse or lung squeeze. We also found that specific respiratory compliance was significantly greater in wild animals than in animals raised under human care. While differences in ages between the two groups may affect this incidental finding, it is also possible that lung conditioning in free-living animals may increase pulmonary compliance and reduce the risk of lung squeeze during diving. Overall, our data indicate that compliance of excised pinniped lungs provide a good estimate of total respiratory compliance.

  14. The course of lung inflation alters the central pattern of tracheobronchial cough in cat-The evidence for volume feedback during cough.

    Science.gov (United States)

    Poliacek, Ivan; Simera, Michal; Veternik, Marcel; Kotmanova, Zuzana; Pitts, Teresa; Hanacek, Jan; Plevkova, Jana; Machac, Peter; Visnovcova, Nadezda; Misek, Jakub; Jakus, Jan

    2016-07-15

    The effect of volume-related feedback and output airflow resistance on the cough motor pattern was studied in 17 pentobarbital anesthetized spontaneously-breathing cats. Lung inflation during tracheobronchial cough was ventilator controlled and triggered by the diaphragm electromyographic (EMG) signal. Altered lung inflations during cough resulted in modified cough motor drive and temporal features of coughing. When tidal volume was delivered (via the ventilator) there was a significant increase in the inspiratory and expiratory cough drive (esophageal pressures and EMG amplitudes), inspiratory phase duration (CTI), total cough cycle duration, and the duration of all cough related EMGs (Tactive). When the cough volume was delivered (via the ventilator) during the first half of inspiratory period (at CTI/2-early over inflation), there was a significant reduction in the inspiratory and expiratory EMG amplitude, peak inspiratory esophageal pressure, CTI, and the overlap between inspiratory and expiratory EMG activity. Additionally, there was significant increase in the interval between the maximum inspiratory and expiratory EMG activity and the active portion of the expiratory phase (CTE1). Control inflations coughs and control coughs with additional expiratory resistance had increased maximum expiratory esophageal pressure and prolonged CTE1, the duration of cough abdominal activity, and Tactive. There was no significant difference in control coughing and/or control coughing when sham ventilation was employed. In conclusion, modified lung inflations during coughing and/or additional expiratory airflow resistance altered the spatio-temporal features of cough motor pattern via the volume related feedback mechanism similar to that in breathing. Copyright © 2016. Published by Elsevier B.V.

  15. Estimating Venezuelas Latent Inflation

    OpenAIRE

    Juan Carlos Bencomo; Hugo J. Montesinos; Hugo M. Montesinos; Jose Roberto Rondo

    2011-01-01

    Percent variation of the consumer price index (CPI) is the inflation indicator most widely used. This indicator, however, has some drawbacks. In addition to measurement errors of the CPI, there is a problem of incongruence between the definition of inflation as a sustained and generalized increase of prices and the traditional measure associated with the CPI. We use data from 1991 to 2005 to estimate a complementary indicator for Venezuela, the highest inflation country in Latin America. Late...

  16. Lung volumes during sustained microgravity on Spacelab SLS-1

    Science.gov (United States)

    Elliott, Ann R.; Prisk, G. Kim; Guy, Harold J. B.; West, John B.

    1994-01-01

    Gravity is known to influence the mechanical behavior of the lung and chest wall. However, the effect of sustained microgravity (microgravity) on lung volumes has not been reported. Pulmonary function tests were performed by four subjects before, during, and after 9 days of microgravity exposure. Ground measurements were made in standing and supine postures. Tests were performed using a bag-in-box-and-flowmeter system and a respiratory mass spectrometer. Measurements included functional residual capacity (FRC), expiratory reserve volume (ERV), residual volume (RV), inspiratory and expiratory vital capacities (IVC and EVC), and tidal volume (V9sub T)). Total lung capacity (TLC) was derived from the measured EVC and RV values. With preflight standing values as a comparison, FRC was significantly reduced by 15% (approximately 500 ml) in microgravity and 32% in the supine posture. ERV was reduced by 10 - 20% in microgravity and decreased by 64% in the supine posture. RV was significantly reduced by 18% (310 ml) in microgravity but did not significantly change in the supine posture compared with standing. IVC and EVC were slightly reduced during the first 24 h of microgravity but returned to 1-G standing values within 72 h of microgravity exposure. IVC and EVC in the supine posture were significantly reduced by 12% compared with standing. During microgravity, V(sub T) decreased by 15% (approximately 90 ml), but supine V(sub T) was unchanged compared with preflight standing values. TLC decreased by approximately 8% during microgravity and in the supine posture compared with preflight standing. The reductions in FRC, ERV, and RV during microgravity are probably due to the cranial shift of the diaphragm, an increase in intrathoracic blood volume, and more uniform alveolar expansion.

  17. Primary Inflation

    OpenAIRE

    Izawa, K. -I.

    1997-01-01

    We consider an inflationary universe scenario with multiple stages of inflation. The primary inflation, which may start at the Planck epoch, is followed by secondary inflations, which include the cosmological inflation that causes the primordial density fluctuations of our universe. We point out that an initial condition for a secondary inflation is naturally realized if the e-fold number of the primary inflation is sufficiently large.

  18. Sustained Adenosine Exposure Causes Lung Endothelial Barrier Dysfunction via Nucleoside Transporter–Mediated Signaling

    Science.gov (United States)

    Newton, Julie; Hsiao, Vivian; Shamirian, Paul; Blackburn, Michael R.; Pedroza, Mesias

    2012-01-01

    Previous studies by our group as well as others have shown that acute adenosine exposure enhances lung vascular endothelial barrier integrity and protects against increased permeability lung edema. In contrast, there is growing evidence that sustained adenosine exposure has detrimental effects on the lungs, including lung edema. It is well established that adenosine modulates lung inflammation. However, little is known concerning the effect of sustained adenosine exposure on lung endothelial cells (ECs), which are critical to the maintenance of the alveolar–capillary barrier. We show that exogenous adenosine plus adenosine deaminase inhibitor caused sustained elevation of adenosine in lung ECs. This sustained adenosine exposure decreased EC barrier function, elevated cellular reactive oxygen species levels, and activated p38, JNK, and RhoA. Inhibition of equilibrative nucleoside transporters (ENTs) prevented sustained adenosine-induced p38 and JNK activation and EC barrier dysfunction. Inhibition of p38, JNK, or RhoA also partially attenuated sustained adenosine-induced EC barrier dysfunction. These data indicate that sustained adenosine exposure causes lung EC barrier dysfunction via ENT-dependent intracellular adenosine uptake and subsequent activation of p38, JNK, and RhoA. The antioxidant N-acetylcysteine and the NADPH inhibitor partially blunted sustained adenosine-induced JNK activation but were ineffective in attenuation of p38 activation or barrier dysfunction. p38 was activated exclusively in mitochondria, whereas JNK was activated in mitochondria and cytoplasm by sustained adenosine exposure. Our data further suggest that sustained adenosine exposure may cause mitochondrial oxidative stress, leading to activation of p38, JNK, and RhoA in mitochondria and resulting in EC barrier dysfunction. PMID:22744860

  19. Lung volume reproducibility under ABC control and self-sustained breath-holding.

    Science.gov (United States)

    Kaza, Evangelia; Dunlop, Alex; Panek, Rafal; Collins, David J; Orton, Matthew; Symonds-Tayler, Richard; McQuaid, Dualta; Scurr, Erica; Hansen, Vibeke; Leach, Martin O

    2017-03-01

    An Active Breathing Coordinator (ABC) can be employed to induce breath-holds during CT imaging and radiotherapy of lung, breast and liver cancer, and recently during lung cancer MRI. The apparatus measures and controls respiratory volume, hence subject lung volume reproducibility is its principal measure of effectiveness. To assess ABC control quality, the intra-session reproducibility of ABC-induced lung volumes was evaluated and compared with that reached by applying the clinical standard of operator-guided self-sustained breath-holds on healthy volunteers during MRI. Inter-session reproducibility was investigated by repeating ABC-controlled breath-holds on a second visit. Additionally, lung volume agreement with ABC devices used with different imaging modalities in the same institution (MR, CT), or for a breast trial treatment, was assessed. Lung volumes were derived from three-dimensional (3D) T1-weighted MRI datasets by three observers employing semiautomatic lung delineation on a radiotherapy treatment planning system. Inter-observer variability was less than 6% of the delineated lung volumes. Lung volume agreement between the different conditions over all subjects was investigated using descriptive statistics. The ABC equipment dedicated for MR application exhibited good intra-session and inter-session lung volume reproducibility (1.8% and 3% lung volume variability on average, respectively). MR-assessed lung volumes were similar using different ABC equipment dedicated to MR, CT, or breast radiotherapy. Overall, lung volumes controlled by the same or different ABC devices agreed better than with self-controlled breath-holds, as suggested by the average ABC variation of 1.8% of the measured lung volumes (99 mL), compared to the 4.1% (226 mL) variability observed on average with self-sustained breath-holding. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in

  20. Grade Inflation.

    Science.gov (United States)

    Taylor, Hugh

    Grade inflation is discussed, and some solutions are offered for the grade inflation problem which exists in the Faculty of Education at the University of Victoria, British Columbia. Examples illustrate the existence of grade inflation at several colleges and universities, as well as at the high school level. Various reactions--involving college…

  1. Deformable registration of the inflated and deflated lung in cone-beam CT-guided thoracic surgery: initial investigation of a combined model- and image-driven approach.

    Science.gov (United States)

    Uneri, Ali; Nithiananthan, Sajendra; Schafer, Sebastian; Otake, Yoshito; Stayman, J Webster; Kleinszig, Gerhard; Sussman, Marc S; Prince, Jerry L; Siewerdsen, Jeffrey H

    2013-01-01

    Surgical resection is the preferred modality for curative treatment of early stage lung cancer, but localization of small tumors (image registration to guide targeting of small tumors in video-assisted thoracic surgery (VATS). A novel algorithm is reported for registration of the lung from its inflated state (prior to pleural breach) to the deflated state (during resection) to localize surgical targets and adjacent critical anatomy. The registration approach geometrically resolves images of the inflated and deflated lung using a coarse model-driven stage followed by a finer image-driven stage. The model-driven stage uses image features derived from the lung surfaces and airways: triangular surface meshes are morphed to capture bulk motion; concurrently, the airways generate graph structures from which corresponding nodes are identified. Interpolation of the sparse motion fields computed from the bounding surface and interior airways provides a 3D motion field that coarsely registers the lung and initializes the subsequent image-driven stage. The image-driven stage employs an intensity-corrected, symmetric form of the Demons method. The algorithm was validated over 12 datasets, obtained from porcine specimen experiments emulating CBCT-guided VATS. Geometric accuracy was quantified in terms of target registration error (TRE) in anatomical targets throughout the lung, and normalized cross-correlation. Variations of the algorithm were investigated to study the behavior of the model- and image-driven stages by modifying individual algorithmic steps and examining the effect in comparison to the nominal process. The combined model- and image-driven registration process demonstrated accuracy consistent with the requirements of minimally invasive VATS in both target localization (∼3-5 mm within the target wedge) and critical structure avoidance (∼1-2 mm). The model-driven stage initialized the registration to within a median TRE of 1.9 mm (95% confidence interval (CI

  2. Lipoxygenase pathway mediates increases of airway resistance and lung inflation induced by exposure to nanotitanium dioxide in rats.

    Science.gov (United States)

    Lee, Jyu-Feng; Tung, Shu-Ping; Wang, David; Yeh, Diana Yuwung; Fong, Yao; Young, Yu-Chung; Leu, Fur-Jiang

    2014-01-01

    Nanotitanium dioxide particle (nTiO2) inhalation has been reported to induce lung parenchymal injury. After inhalation of nTiO2, we monitored changes in 5-lipoxygenase, endothelial nitric oxide synthase (eNOS), and inducible nitric oxide synthase (iNOS) mRNA in rat lung tissue. Lung function parameters include specific airway resistance (SRaw), peak expiratory flow rate (PEF), functional residual capacity (FRC), and lung compliance (Cchord); blood white blood cell count (WBC), nitric oxide (NO), hydrogen peroxide, and lactic dehydrogenase (LDH); and lung lavage leukotriene C4, interleukin 6 (IL6), tumor necrotic factor α (TNFα), hydroxyl radicals, and NO. Leukotriene receptor antagonist MK571 and 5-lipoxygenase inhibitor MK886 were used for pharmacologic intervention. Compared to control, nTiO2 exposure induced near 5-fold increase in 5-lipoxygenase mRNA expression in lung tissue. iNOS mRNA increased while eNOS mRNA decreased. Lavage leukotriene C4; IL6; TNFα; NO; hydroxyl radicals; and blood WBC, NO, hydrogen peroxide, and LDH levels rose. Obstructive ventilatory insufficiency was observed. MK571 and MK886 both attenuated the systemic inflammation and lung function changes. We conclude that inhaled nTiO2 induces systemic inflammation, cytokine release, and oxidative and nitrosative stress in the lung. The lipoxygenase pathway products, mediated by oxygen radicals and WBC, play a critical role in the obstructive ventilatory insufficiency induced by nTiO2.

  3. Inflation and Inflation Uncertainty in Turkey

    OpenAIRE

    dogru, bulent

    2014-01-01

    Abstract: In this study, the relationship between inflation and inflation uncertainty is analyzed using Granger causality tests with annual inflation series covering the time period 1923 to 2012 for Turkish Economy. Inflation uncertainty is measured by Exponential Generalized Autoregressive Conditional Heteroskedastic model. Econometric findings suggest that although in long run the Friedman's hypothesis that high inflation increases inflation ...

  4. Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation.

    Science.gov (United States)

    Baluk, Peter; Adams, Alicia; Phillips, Keeley; Feng, Jennifer; Hong, Young-Kwon; Brown, Mary B; McDonald, Donald M

    2014-05-01

    Lymphatics proliferate, become enlarged, or regress in multiple inflammatory lung diseases in humans. Lymphatic growth and remodeling is known to occur in the mouse trachea in sustained inflammation, but whether intrapulmonary lymphatics exhibit similar plasticity is unknown. We examined the time course, distribution, and dependence on vascular endothelial growth factor receptor (VEGFR)-2/VEGFR-3 signaling of lung lymphatics in sustained inflammation. Lymphatics in mouse lungs were examined under baseline conditions and 3 to 28 days after Mycoplasma pulmonis infection, using prospero heomeobox 1-enhanced green fluorescence protein and VEGFR-3 as markers. Sprouting lymphangiogenesis was evident at 7 days. Lymphatic growth was restricted to regions of bronchus-associated lymphoid tissue (BALT), where VEGF-C-producing cells were scattered in T-cell zones. Expansion of lung lymphatics after infection was reduced 68% by blocking VEGFR-2, 83% by blocking VEGFR-3, and 99% by blocking both receptors. Inhibition of VEGFR-2/VEGFR-3 did not prevent the formation of BALT. Treatment of established infection with oxytetracycline caused BALT, but not the lymphatics, to regress. We conclude that robust lymphangiogenesis occurs in mouse lungs after M. pulmonis infection through a mechanism involving signaling of both VEGFR-2 and VEGFR-3. Expansion of the lymphatic network is restricted to regions of BALT, but lymphatics do not regress when BALT regresses after antibiotic treatment. The lung lymphatic network can thus expand in sustained inflammation, but the expansion is not as reversible as the accompanying inflammation. Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  5. Inflation lung mechanics deteriorates markedly after saline instillation and open endotracheal suctioning in mechanically ventilated healthy piglets.

    Science.gov (United States)

    Cunha-Goncalves, Doris; Perez-de-Sá, Valéria; Ingimarsson, Jónas; Werner, Olof; Larsson, Anders

    2007-01-01

    Non-bronchoscopic bronchoalveolar lavage is an alternative to diagnostic bronchoscopy in pediatric patients, as fiberoptic bronchoscopes with aspiration channels are too large for small infants. There are many variations of the method in clinical practice, and saline instillation followed by open endotracheal suctioning is still commonly used. Lung function can deteriorate with these procedures, and we have investigated the effects on lung mechanics and oxygenation in healthy piglets. The lungs of anesthetized and mechanically ventilated piglets were recruited with CPAP 35 cmH2O. Thereafter we instilled 5 ml of saline into the endotracheal tube, followed by three breaths from the ventilator. Saline was retrieved through a suction catheter wedged far distally in the airway. The procedure was followed by a new recruitment maneuver. Complete inspiratory/expiratory pressure - volume loops (PV-loops) were obtained just before and 5 min after saline instillation. Arterial blood gases were collected at equivalent times in 14 similar piglets submitted to exactly the same procedure. The inspiratory limb of the PV-loops changed markedly, as the lower inflection point was displaced towards higher pressures (P=0.004), and hysteresis measured at 15 and 30 cmH2O increased (P=0.004 and P=0.012, respectively). Although PaO2 decreased significantly (P=0.001), values after saline instillation/suctioning were still in the high normal range, that is, 22.2 +/- 2.6 kPa. Opening pressures of the lungs increase markedly after saline instillation/suctioning in healthy piglets. In this situation, adequate recruitment maneuvers and PEEP might prevent lung collapse and deteriorations in arterial oxygenation. (c) 2006 Wiley-Liss, Inc.

  6. Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression.

    Directory of Open Access Journals (Sweden)

    Paul T King

    Full Text Available Nontypeable Haemophilus influenzae (NTHi is a prevalent bacterium found in a variety of chronic respiratory diseases. The role of this bacterium in the pathogenesis of lung inflammation is not well defined. In this study we examined the effect of NTHi on two important lung inflammatory processes 1, oxidative stress and 2, protease expression. Bronchoalveolar macrophages were obtained from 121 human subjects, blood neutrophils from 15 subjects, and human-lung fibroblast and epithelial cell lines from 16 subjects. Cells were stimulated with NTHi to measure the effect on reactive oxygen species (ROS production and extracellular trap formation. We also measured the production of the oxidant, 3-nitrotyrosine (3-NT in the lungs of mice infected with this bacterium. NTHi induced widespread production of 3-NT in mouse lungs. This bacterium induced significantly increased ROS production in human fibroblasts, epithelial cells, macrophages and neutrophils; with the highest levels in the phagocytic cells. In human macrophages NTHi caused a sustained, extracellular production of ROS that increased over time. The production of ROS was associated with the formation of macrophage extracellular trap-like structures which co-expressed the protease metalloproteinase-12. The formation of the macrophage extracellular trap-like structures was markedly inhibited by the addition of DNase. In this study we have demonstrated that NTHi induces lung oxidative stress with macrophage extracellular trap formation and associated protease expression. DNase inhibited the formation of extracellular traps.

  7. Spiral inflation

    Directory of Open Access Journals (Sweden)

    Gabriela Barenboim

    2015-02-01

    Full Text Available We propose a novel scenario of primordial inflation in which the inflaton goes through a spiral motion starting from around the top of a symmetry breaking potential. We show that, even though inflation takes place for a field value much smaller than Planck scale, it is possible to obtain relatively large tensor-to-scalar ratio (r∼0.1 without fine tuning. The inflationary observables perfectly match Planck data.

  8. Double inflation

    Energy Technology Data Exchange (ETDEWEB)

    Silk, J.; Turner, M.S.

    1986-04-01

    The Zel'dovich spectrum of adiabatic density perturbations is a generic prediction of inflation. There is increasing evidence that when the spectrum is normalized by observational data on small scales, there is not enough power on large scales to account for the observed large-scale structure in the Universe. Decoupling the spectrum on large and small scales could solve this problem. As a means of decoupling the large and small scales we propose double inflation (i.e., two episodes of inflation). In this scenario the spectrum on large scales is determined by the first episode of inflation and those on small scales by a second episode of inflation. We present three models for such a scenario. By nearly saturating the large angular-scale cosmic microwave anisotropy bound, we can easily account for the observed large-scale structure. We take the perturbations on small scales to be very large, deltarho/rho approx. = 0.1 to 0.01, which results in the production of primordial black holes (PBHs), early formation of structure, reionization of the Universe, and a rich array of astrophysical events. The ..cap omega..-problem is also addressed by our scenario. Allowing the density perturbations produced by the second episode of inflation to be large also lessens the fine-tuning required in the scalar potential and makes reheating much easier. We briefly speculate on the possibility that the second episode of inflation proceeds through the nucleation of bubbles, which today manifest themselves as empty bubbles whose surfaces are covered with galaxies. 37 refs., 1 fig.

  9. Symmetron inflation

    Science.gov (United States)

    Dong, Ruifeng; Kinney, William H.; Stojkovic, Dejan

    2014-01-01

    We define a new inflationary scenario in which inflation starts naturally after the Big Bang when the energy density drops below some critical value. As a model, we use recently proposed symmetron field whose effective potential depends on the energy density of the environment. At high densities, right after the Big Bang, the potential for the symmetron is trivial, and the field sits in equilibrium at the bottom of the potential. When the density drops below some critical value, the potential changes its shape into a symmetry breaking potential, and the field starts rolling down. This scenario does not require any special initial conditions for inflation to start. We also construct a concrete model with two fields, i.e. with symmetron as an inflaton and an additional scalar field which describes the matter content in the early universe. For the simplest coupling, the amplitude and shape of the power spectrum are the same as in the single field slow-roll inflation.

  10. Eternal inflation

    CERN Document Server

    Winitzki, Sergei

    2009-01-01

    This volume is the only monograph covering the exciting and dazzling recent developments in quantum cosmology, including the theory of the "multiverse" and eternal inflation pioneered by A Vilenkin, A Linde, S W Hawking, and others. Written by a leading expert in the field known for his depth and clarity of presentation, the volume presents an overview of 20 years of development of the theory of eternal inflation as well as a comprehensive, research-level introduction into the current methods and problems. This volume is invaluable for researchers as a definitive reference in the rapidly devel

  11. Trapped Inflation

    Energy Technology Data Exchange (ETDEWEB)

    Green, Daniel; Horn, Bart; /SLAC /Stanford U., Phys. Dept.; Senatore, Leonardo; /Princeton, Inst. Advanced Study /Harvard U., Phys. Dept. /Harvard-Smithsonian Ctr. Astrophys.; Silverstein, Eva; /SLAC /Stanford U., Phys. Dept.

    2009-06-19

    We analyze a distinctive mechanism for inflation in which particle production slows down a scalar field on a steep potential, and show how it descends from angular moduli in string compactifications. The analysis of density perturbations - taking into account the integrated effect of the produced particles and their quantum fluctuations - requires somewhat new techniques that we develop. We then determine the conditions for this effect to produce sixty e-foldings of inflation with the correct amplitude of density perturbations at the Gaussian level, and show that these requirements can be straightforwardly satisfied. Finally, we estimate the amplitude of the non-Gaussianity in the power spectrum and find a significant equilateral contribution.

  12. Natural inflation

    Energy Technology Data Exchange (ETDEWEB)

    Frieman, J.A.

    1991-02-01

    A pseduo-Nambu-Goldstone boson, with a potential of the form V({phi}) = {Lambda}{sup 4}(1 {plus minus} cos({phi}/f)), can naturally give rise to an epoch of inflation in the early universe. Successful inflation can be achieved if f {approximately} m{sub pl} and {Lambda} {approximately} m{sub GUT}. Such mass scales arise in particle physics models with a gauge group that becomes strongly interacting a the GUT scale, e.g., as is expected to happen in the hidden sector of superstring theories. The density fluctuation spectrum is a non-scale-invariant power law, with extra power on large scales. 12 refs., 3 figs.

  13. Clockwork Inflation

    CERN Document Server

    Kehagias, Alex

    2017-01-01

    We investigate the recently proposed clockwork mechanism delivering light degrees of freedom with suppressed interactions and show, with various examples, that it can be efficiently implemented in inflationary scenarios to generate flat inflaton potentials and small density perturbations without fine-tunings. We also study the clockwork graviton in de Sitter and, interestingly, we find that the corresponding clockwork charge is site-dependent. As a consequence, the amount of tensor modes is generically suppressed with respect to the standard cases where the clockwork set-up is not adopted. This point can be made a virtue in resurrecting models of inflation which were supposed to be ruled out because of the excessive amount of tensor modes from inflation.

  14. Clockwork inflation

    Energy Technology Data Exchange (ETDEWEB)

    Kehagias, Alex, E-mail: kehagias@central.ntua.gr [Physics Division, National Technical University of Athens, 15780 Zografou Campus, Athens (Greece); Theoretical Physics Department, CERN, CH-1211 Geneva 23 (Switzerland); Riotto, Antonio [Department of Theoretical Physics and Center for Astroparticle Physics (CAP), 24 quai E. Ansermet, CH-1211 Geneva 4 (Switzerland)

    2017-04-10

    We investigate the recently proposed clockwork mechanism delivering light degrees of freedom with suppressed interactions and show, with various examples, that it can be efficiently implemented in inflationary scenarios to generate flat inflaton potentials and small density perturbations without fine-tunings. We also study the clockwork graviton in de Sitter and, interestingly, we find that the corresponding clockwork charge is site-dependent. As a consequence, the amount of tensor modes is generically suppressed with respect to the standard cases where the clockwork set-up is not adopted. This point can be made a virtue in resurrecting models of inflation which were supposed to be ruled out because of the excessive amount of tensor modes from inflation.

  15. Khronon inflation

    Energy Technology Data Exchange (ETDEWEB)

    Creminelli, Paolo [Abdus Salam International Centre for Theoretical Physics, Strada Costiera 11, 34151, Trieste (Italy); Noreña, Jorge [ICC, University of Barcelona (IEEC-UB), Marti i Franques 1, Barcelona 08028 (Spain); Peña, Manuel [Depto. de Física Teórica and IFIC, Universdad de Valencia-CSIC, Edificio de Institutos de Paterna, E-46980, Paterna (Valencia) (Spain); Simonović, Marko, E-mail: creminel@ictp.it, E-mail: jorge.norena@icc.ub.edu, E-mail: mapeji@ific.uv.es, E-mail: marko.simonovic@sissa.it [SISSA, via Bonomea 265, 34136, Trieste (Italy)

    2012-11-01

    We study the possibility that the approximate time shift symmetry during inflation is promoted to the full invariance under time reparametrization t → t-tilde (t), or equivalently under field redefinition of the inflaton φ → φ-tilde (φ). The symmetry allows only two operators at leading order in derivatives, so that all n-point functions of scalar perturbations are fixed in terms of the power spectrum normalization and the speed of sound. During inflation the decaying mode only decays as 1/a and this opens up the possibility to violate some of the consistency relations in the squeezed limit, although this violation is suppressed by the (small) breaking of the field reparametrization symmetry. In particular one can get terms in the 3-point function that are only suppressed by 1/k{sub L} in the squeezed limit k{sub L}→0 compared to the local shape.

  16. Clockwork inflation

    Directory of Open Access Journals (Sweden)

    Alex Kehagias

    2017-04-01

    Full Text Available We investigate the recently proposed clockwork mechanism delivering light degrees of freedom with suppressed interactions and show, with various examples, that it can be efficiently implemented in inflationary scenarios to generate flat inflaton potentials and small density perturbations without fine-tunings. We also study the clockwork graviton in de Sitter and, interestingly, we find that the corresponding clockwork charge is site-dependent. As a consequence, the amount of tensor modes is generically suppressed with respect to the standard cases where the clockwork set-up is not adopted. This point can be made a virtue in resurrecting models of inflation which were supposed to be ruled out because of the excessive amount of tensor modes from inflation.

  17. Single Sustained Inflation followed by Ventilation Leads to Rapid Cardiorespiratory Recovery but Causes Cerebral Vascular Leakage in Asphyxiated Near-Term Lambs.

    Directory of Open Access Journals (Sweden)

    Kristina S Sobotka

    Full Text Available A sustained inflation (SI rapidly restores cardiac function in asphyxic, bradycardic newborns but its effects on cerebral haemodynamics and brain injury are unknown. We determined the effect of different SI strategies on carotid blood flow (CaBF and cerebral vascular integrity in asphyxiated near-term lambs.Lambs were instrumented and delivered at 139 ± 2 d gestation and asphyxia was induced by delaying ventilation onset. Lambs were randomised to receive 5 consecutive 3 s SI (multiple SI; n = 6, a single 30 s SI (single SI; n = 6 or conventional ventilation (no SI; n = 6. Ventilation continued for 30 min in all lambs while CaBF and respiratory function parameters were recorded. Brains were assessed for gross histopathology and vascular leakage.CaBF increased more rapidly and to a greater extent during a single SI (p = 0.01, which then decreased below both other groups by 10 min, due to a higher cerebral oxygen delivery (p = 0.01. Blood brain barrier disruption was increased in single SI lambs as indicated by increased numbers of blood vessel profiles with plasma protein extravasation (p = 0.001 in the cerebral cortex. There were no differences in CaBF or cerebral oxygen delivery between the multiple SI and no SI lambs.Ventilation with an initial single 30 s SI improves circulatory recovery, but is associated with greater disruption of blood brain barrier function, which may exacerbate brain injury suffered by asphyxiated newborns. This injury may occur as a direct result of the initial SI or to the higher tidal volumes delivered during subsequent ventilation.

  18. Inflation Protected Investment Strategies

    National Research Council Canada - National Science Library

    Mirco Mahlstedt; Rudi Zagst

    2016-01-01

    .... Different stock market, as well as inflation regimes are identified, and within those regimes, the inflation hedging potential of stocks, bonds, real estate, commodities and gold are investigated...

  19. Composite Inflation Setup and Glueball Inflation

    DEFF Research Database (Denmark)

    Bezrukov, Fedor; Channuie, Phongpichit; Jark Joergensen, Jakob

    2012-01-01

    We explore the paradigm according to which inflation is driven by a four-dimensional strongly coupled dynamics coupled non-minimally to gravity. We start by introducing the general setup, both in the metric and Palatini formulation, for generic models of composite inflation. We then analyze......-minimally to gravity. We demonstrate that it is possible to achieve successful inflation with the confining scale of the underlying Yang-Mills theory naturally of the order of the grand unified energy scale. We also argue that within the metric formulation models of composite inflation lead to a more consistent...

  20. Inflation persistence in African countries: Does inflation targeting matter?

    OpenAIRE

    Phiri, Andrew

    2016-01-01

    This study investigates inflation persistence in annual CPI inflation collected between 1994 and 2014 for 46 African countries. We group these countries into panels according to whether they are inflation targeters or not and conduct estimations for pre and post inflation targeting periods. Interestingly enough, we find that inflation persistence was much higher for inflation targeters in periods before adopting their inflation targeting regimes and inflation persistence dropped by 40 percent...

  1. Inflation Basics

    Energy Technology Data Exchange (ETDEWEB)

    Green, Dan [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2014-03-01

    inflation since metrical fluctuations, both scalar and tensor, are also produced in inflationary models. Thus, the time appears to be appropriate for a very basic and simple exposition of the inflationary model written from a particle physics perspective. Only the simplest scalar model will be explored because it is easy to understand and contains all the basic elements of the inflationary model.

  2. Use of self-inflating bags for neonatal resuscitation.

    Science.gov (United States)

    Oddie, Sam; Wyllie, Jonathan; Scally, Andrew

    2005-10-01

    Lung inflation is the most important, and most difficult step in newborn resuscitation. A wide variety of devices are used to achieve lung inflation, but there are relatively few data to guide clinicians in their choice of device. We tested the ability of instructors and trained candidates on a newborn life support course to deliver initial inflation breaths to a test lung, using a pressure limited blow-off valve, a 240-ml self-inflating bag and a 500-ml self-inflating bag in sequence. Use of a 240-ml self-inflating bag was associated with shorter initial inflations of 1.8 s mean (95% CI 1.60-1.99 s), compared with 2.42 s (2.24-2.61 s), 2.40 s (2.08-2.71 s) for 500-ml self-inflating bags and "Tom Thumb" T piece, respectively. Delivery of breaths within a target pressure range of 30+/-5 cm H2O was significantly better using a T piece than either self-inflating bag (proportion within target range 0.05 (95% CI 0-0.11), 0.17 (95% CI 0.12-0.23), 0.89 (95% CI 0.83-0.94) for 240-ml and 500-ml self-inflating bags and "Tom Thumb" T piece, respectively. Excessive pressure delivery with both sizes of self-inflating bag was frequent. These data do not support use of 240-ml or 500-ml self-inflating bags for resuscitation of newborn term infants. A variable pressure T piece blow-off system may be the easiest device to use for newborn resuscitation and the most reliable at delivering desired pressures for set times.

  3. First-order inflation

    Energy Technology Data Exchange (ETDEWEB)

    Kolb, E.W. (Fermi National Accelerator Lab., Batavia, IL (USA) Chicago Univ., IL (USA). Enrico Fermi Inst.)

    1990-09-01

    In the original proposal, inflation occurred in the process of a strongly first-order phase transition. This model was soon demonstrated to be fatally flawed. Subsequent models for inflation involved phase transitions that were second-order, or perhaps weakly first-order; some even involved no phase transition at all. Recently the possibility of inflation during a strongly first-order phase transition has been revived. In this talk I will discuss some models for first-order inflation, and emphasize unique signatures that result in inflation is realized in a first-order transition. Before discussing first-order inflation, I will briefly review some of the history of inflation to demonstrate how first-order inflation differs from other models. 58 refs., 3 figs.

  4. Inflation Protected Investment Strategies

    Directory of Open Access Journals (Sweden)

    Mirco Mahlstedt

    2016-03-01

    Full Text Available In this paper, a dynamic inflation-protected investment strategy is presented, which is based on traditional asset classes and Markov-switching models. Different stock market, as well as inflation regimes are identified, and within those regimes, the inflation hedging potential of stocks, bonds, real estate, commodities and gold are investigated. Within each regime, we determine optimal investment portfolios driven by the investment idea of protection from losses due to changing inflation if inflation is rising or high, but decoupling the performance from inflation if inflation is low. The results clearly indicate that these asset classes behave differently in different stock market and inflation regimes. Whereas in the long-run, we agree with the general opinion in the literature that stocks and bonds are a suitable hedge against inflation, we observe for short time horizons that the hedging potential of each asset class, especially of real estate and commodities, depend strongly on the state of the current market environment. Thus, our approach provides a possible explanation for different statements in the literature regarding the inflation hedging properties of these asset classes. A dynamic inflation-protected investment strategy is developed, which combines inflation protection and upside potential. This strategy outperforms standard buy-and-hold strategies, as well as the well-known 1 N -portfolio.

  5. Hillclimbing Higgs inflation

    OpenAIRE

    Jinno, Ryusuke; Kaneta, Kunio; Oda, Kin-ya

    2017-01-01

    We propose a realization of cosmic inflation with the Higgs field when the Higgs potential has degenerate vacua by employing the recently proposed idea of hill-climbing inflation. The resultant inflationary predictions exhibit a sizable deviation from those of the ordinary Higgs inflation.

  6. Inflation and asset prices

    OpenAIRE

    Tatom, John

    2011-01-01

    Changes in the general level of prices and inflation have profound effects on asset prices. There are several reasons for these effects and the influence differs depending on the source of the inflation and whether it is expected or not. To understand these effects it is important to clarify what is meant by inflation, the pure theory of the sources of inflation, how inflation affects goods and services prices and how it affects the assets that are used to finance production, both equity pr...

  7. k-Inflation

    Science.gov (United States)

    Armendáriz-Picón, C.; Damour, T.; Mukhanov, V.

    1999-07-01

    It is shown that a large class of higher-order (i.e. non-quadratic) scalar kinetic terms can, without the help of potential terms, drive an inflationary evolution starting from rather generic initial conditions. In many models, this kinetically driven inflation (or ``k-inflation'' for short) rolls slowly from a high-curvature initial phase, down to a low-curvature phase and can exit inflation to end up being radiation-dominated, in a naturally graceful manner. We hope that this novel inflation mechanism might be useful in suggesting new ways of reconciling the string dilaton with inflation.

  8. Tomography assessment of lung hyper inflation areas within cats in a pressure controlled ventilation staggered; Avaliacao tomografica das areas de de hiperinsuflacao pulmonar em gatos submetidos a ventilacao controlada a pressao escalonada

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Alessandro Rodrigues de Carvalho, E-mail: doutorevet@hotmail.com [Universidade de Sao Paulo (FM/USP), SP (Brazil). Faculdade de Medicina. Programa de Anestesiologia; Fantoni, Denise Tabacchi; Ambrosio, Aline Magalhaes [Universidade de Sao Paulo (FMVZ/USP), SP (Brazil). Faculdade de Medicina Veterinaria e Zootecnia; Santos, Jaqueline Franca dos; Villamizar, Lenin Arturo [Universidade de Sao Paulo (FMVZ/USP), SP (Brazil). Faculdade de Medicina Veterinaria e Zootecnia. Programa de Cirurgia; Pinto, Ana Carolina Brandao de Campos Fonseca [Universidade de Sao Paulo (USP), SP (Brazil). Faculdade de Medicina Veterinaria e Zootecnia. Disciplina de Diagnostico por Imagem; Martins, Thiago do Amaral [UFAPE Vet Intenziv, Itapecerica da Serra, SP (Brazil); Malbouisson, Luis Marcelo Sa [Universidade de Sao Paulo (HC/USP), SP (Brazil). Faculdade de Medicina. UTI Anestesiologica

    2012-07-01

    Mechanical ventilation is essential for oxygen supply during anesthesia. Some strategies are related to lung injury associated with mechanical ventilation. 10 cats, 4±1 kg, 1-6 years old, induced and maintained with propofol (6mg/kg, 0,5mg/kg/min) placed in supine position, subjected to pressure controlled ventilation (PCV) in oxygen at 40% with 5cmH{sub 2}O peak pressure in 'ZEEP' for 20 minutes, rising in 2cmH{sub 2}O installments peak pressure every five minutes until it reached 15cmH{sub 2}O. Moments P5, P7, P9, P11, P13, P15. Respiratory rate and inspiratory time were held on 15 movements per minute and 1 second regardless their EtCO{sub 2}. Muscle relaxation achieved by rocuronium bollus (1mg/kg/IV). Immediately, at each increase on pressure was performed a 4 seconds' inspiratory pause to allow the five millimeters CT slice of diaphragmatic region followed by hemogasometric and cardiorespiratory variables collected. P5 had the smallest hyperinflated area (3,24±4,02) Compared to other moments. P5 blood gases showed acidaemia (7,257±0,08) for mild respiratory acidosis (45±9.2) with good oxygenation (178±40.8mmHg) compared to other times which obtained reduction of CO{sub 2} and an increased pH. As the increase in peak pressure was observed increased distension of the lung parenchyma, a fact related to possible risk of lung injury in prolonged periods. 5cmH{sub 2}O pressure was demonstrated to be less harmful due to its lower hyper inflated areas that other moments, even with a low pH and high CO{sub 2}, being corrected by increasing respiratory rate.

  9. Towards a formal link between inflation perceptions and inflation ...

    African Journals Online (AJOL)

    This paper reports the finding of a survey of inflation perceptions and inflation expectations in South Africa undertaken in 2014. This survey posed questions on perceptions of past inflation (historic inflation) and expectations of future inflation to the same respondents and determined linkages between historic views and ...

  10. Sustained function of genetically modified porcine lungs in an ex vivo model of pulmonary xenotransplantation.

    Science.gov (United States)

    Westall, Glen P; Levvey, Browyn J; Salvaris, Evelyn; Gooi, Julian; Marasco, Sylvana; Rosenfeldt, Frank; Egan, Chris; McEgan Ccp, Robin; Mennen, Mark; Russell, Prue; Robson, Simon C; Nottle, Mark B; Dwyer, Karen M; Snell, Greg I; Cowan, Peter J

    2013-11-01

    Xenotransplantation could provide a solution to the donor shortage that is currently the major barrier to solid-organ transplantation. The ability to breed pigs with multiple genetic modifications provides a unique opportunity to explore the immunologic challenges of pulmonary xenotransplantation. Explanted lungs from wild-type and 3 groups of genetically modified pigs were studied: (i) α1,3-galactosyltransferase gene knockout (GTKO); (ii) GTKO pigs expressing the human complementary regulatory proteins CD55 and CD59 (GTKO/CD55-59); and (iii) GTKO pigs expressing both CD55-59 and CD39 (GTKO/CD55-59/CD39). The physiologic, immunologic and histologic properties of porcine lungs were evaluated on an ex vivo rig after perfusion with human blood. Lungs from genetically modified pigs demonstrated stable pulmonary vascular resistance and better oxygenation of the perfusate, and survived longer than wild-type lungs. Physiologic function was inversely correlated with the degree of platelet sequestration into the xenograft. Despite superior physiologic profiles, lungs from genetically modified pigs still showed evidence of intravascular thrombosis and coagulopathy after perfusion with human blood. The ability to breed pigs with multiple genetic modifications, and to evaluate lung physiology and histology in real-time on an ex vivo rig, represent significant advances toward better understanding the challenges inherent to pulmonary xenotransplantation. © 2013 International Society for Heart and Lung Transplantation. All rights reserved.

  11. Population Pharmacokinetics of Colistin Methanesulfonate in Rats: Achieving Sustained Lung Concentrations of Colistin for Targeting Respiratory Infections

    Science.gov (United States)

    W. S. Yapa, Shalini; Li, Jian; Porter, Christopher J. H.; Nation, Roger L.

    2013-01-01

    Colistin methanesulfonate (CMS), the inactive prodrug of colistin, is administered by inhalation for the management of respiratory infections. However, limited pharmacokinetic data are available for CMS and colistin following pulmonary delivery. This study investigates the pharmacokinetics of CMS and colistin following intravenous (i.v.) and intratracheal (i.t.) administration in rats and determines the targeting advantage after direct delivery into the lungs. In addition to plasma, bronchoalveolar lavage (BAL) fluid was collected to quantify drug concentrations in lung epithelial lining fluid (ELF). The resulting data were analyzed using a population modeling approach in S-ADAPT. A three-compartment model described the disposition of both compounds in plasma following i.v. administration. The estimated mean clearance from the central compartment was 0.122 liters/h for CMS and 0.0657 liters/h for colistin. Conversion of CMS to colistin from all three compartments was required to fit the plasma data. The fraction of the i.v. dose converted to colistin in the systemic circulation was 0.0255. Two BAL fluid compartments were required to reflect drug kinetics in the ELF after i.t. dosing. A slow conversion of CMS (mean conversion time [MCTCMS] = 3.48 h) in the lungs contributed to high and sustained concentrations of colistin in ELF. The fraction of the CMS dose converted to colistin in ELF (fm,ELF = 0.226) was higher than the corresponding fractional conversion in plasma after i.v. administration. In conclusion, pulmonary administration of CMS achieves high and sustained exposures of colistin in lungs for targeting respiratory infections. PMID:23917323

  12. Is Inflation Persistence Over?

    Directory of Open Access Journals (Sweden)

    Fernando N. de Oliveira

    2014-09-01

    Full Text Available We analyze inflation persistence in several industrial and emerging countries in the recent past by implementing unit root tests in the presence of unknown structural breaks and by estimating reduced-form models of inflation dynamics. We select a very representative group of 23 industrial and 17 emerging economies. Our sample period is comprised of quarterly data and differs for each country. Our results indicate that inflation persistence is decreasing over time for the great majority of industrial economies. Many emerging economies, however, show increasing persistence and even a few have highly persistent inflationary processes. We also observe structural breaks in all inflation processes we study with the exception of the inflation processes of Germany and Austria. Our results are robust to different reduced forms of the inflation processes and different econometric techniques.

  13. INFLATION AND TAXATION

    OpenAIRE

    Glenn Jenkins; HEDI LAHOUEL

    1981-01-01

    Inflation induces distortions in the economy, some of which are related to taxation while others would persist even if tax systems were made fully neutral with respect to rate of inflation. It is well known for instance that inflation induces individuals to hold less real cash balances and to invest relatively more in assets that maintain their purchasing power than they would in a non- inflationary world. This paper does not deal with this kind of distortion. It focuses on effects of inflati...

  14. Radiative plateau inflation

    CERN Document Server

    Ballesteros, Guillermo

    2016-01-01

    We describe how monomial chaotic inflation becomes compatible with the latest CMB data thanks to radiative corrections producing a plateau. The interactions of the inflation with other fields, required for reheating, can flatten the potential and moderate the production of primordial gravitational waves, keeping these below the current upper bound. We show that the appearance of a plateau requires that the inflaton couples to fermions and to another scalar or a gauge group. We give concrete examples of minimal particle physics models leading to plateaus for quadratic and quartic chaotic inflation. We also provide a three-parameter model-independent description of radiatively corrected inflation that is amenable to CMB analyses.

  15. Natural chaotic inflation

    Energy Technology Data Exchange (ETDEWEB)

    Papantonopoulos, E.; Uematsu, T.; Yanagida, T.

    1987-01-15

    We present a chaotic inflationary model, in which nonlinear interactions of dilaton and axion fields in the context of the superconformal theory can dynamically give rise to initial conditions for the inflation of the universe and a flat potential that can produce enough inflation. Our model is free from dangerous thermal effects and large energy density fluctuations.

  16. The inflation sector of extended inflation

    Science.gov (United States)

    Kolb, Edward W.

    1991-01-01

    In extended inflation, the inflationary era is brought to a close by the process of percolation of true vacuum bubbles produced in a first-order phase transition. This paper discusses several effects that might obtain if the universe undergoes an inflationary first-order phase transition.

  17. The Role of Anion Exchanger on Pulmonary Vascular Response to Sustained Alveolar Hypoxia in the Isolated Perfused Rabbit Lung

    Directory of Open Access Journals (Sweden)

    Farzaneh Ketabchi

    2015-05-01

    Full Text Available Background: Some respiratory diseases may induce alveolar hypoxia thereby hypoxic pulmonary vasoconstriction (HPV. However, the mechanisms of this physiologic phenomenon are not fully understood. This study was the first to investigate the role of anion exchanger in sustained HPV. Methods: Experiments were performed in the isolated perfused rabbit lung. After preparation, the lungs were divided into six groups: two DIDS (4,4-diisothiocyanostilbene 2,2-disulfonic acid, anion exchanger inhibitor-treated [200 µM (n=5 or 400 µM (n=3] hypoxic groups, two HCO3- free hypoxic groups, one control hypoxic group (n=7 and one control normoxic group (n=4. DIDS were added to the perfusate at 10 minutes before starting the experiments. In the HCO3- free groups, HEPES (4-(2-Hydroxyethylpiperazine-1-ethanesulfonic acid were added to the perfusate instead of bicarbonate. Furthermore, in the HEPES1 (n=4 and HEPES2 (n=4 groups, the lungs were ventilated with hypoxic gas with or without CO2, respectively. Results: Ventilation of the lungs with hypoxic gas resulted in biphasic HPV, the acute (0-20 minutes and sustained (20-60 minutes phases. No alteration in both phases of HPV was detected by DIDS (200 µM. However, DIDS (400 µM, extended the ascending part of acute HPV until min 24. Both phases of HPV were decreased in the HEPES1 group. However, in the HEPES 2 group, HPV tended to increase during the rising part of the acute phase of HPV. Conclusions: Since DIDS (400 µM extended acute phase of HPV, and HCO3- free perfusate buffer enhanced rising phase of it, therefore it can be suggested that anion exchanger may modulate HPV especially during the acute phase. The abstract of this article was presented as a poster in the congress of European Respiratory Society (ERS on Monday, 08 September 2014, Munich, Germany and was published in the ERJ September 1, 2014 vol. 44 no. Suppl 58 P2343.

  18. Inflation perceptions and inflation expectation in South Africa: trends ...

    African Journals Online (AJOL)

    This paper reports the results of a multinomial analysis of inflation perceptions and inflation expectations in South Africa. Inflation perceptions surveys among South African individuals have been undertaken since 2006. The introduction of these surveys followed on domestic inflation expectation surveys conducted in 2000, ...

  19. Inflation, inflation uncertainty and output growth in the USA

    Science.gov (United States)

    Bhar, Ramprasad; Mallik, Girijasankar

    2010-12-01

    Employing a multivariate EGARCH-M model, this study investigates the effects of inflation uncertainty and growth uncertainty on inflation and output growth in the United States. Our results show that inflation uncertainty has a positive and significant effect on the level of inflation and a negative and significant effect on the output growth. However, output uncertainty has no significant effect on output growth or inflation. The oil price also has a positive and significant effect on inflation. These findings are robust and have been corroborated by use of an impulse response function. These results have important implications for inflation-targeting monetary policy, and the aim of stabilization policy in general.

  20. Inflation and Brane Gases

    OpenAIRE

    Brandenberger, Robert; Easson, Damien A.; Mazumdar, Anupam

    2003-01-01

    We investigate a new way of realizing a period of cosmological inflation in the context of brane gas cosmology. It is argued that a gas of co-dimension one branes, out of thermal equilibrium with the rest of the matter, has an equation of state which can - after stabilization of the dilaton - lead to power-law inflation of the bulk. The most promising implementation of this mechanism might be in Type IIB superstring theory, with inflation of the three large spatial dimensions triggered by ``s...

  1. Euro area Inflation as a Predictor of National Inflation Rates

    OpenAIRE

    Cavallo, Antonella; Ribba, Antonio

    2013-01-01

    The stability of inflation differentials is an important condition for the smooth working of a currency area, such as the European Economic and Monetary Union. In the presence of stability, changes in national inflation rates, while holding Euro-area inflation fixed contemporaneously, should be only transitory. If this is the case, the rate of inflation of the whole area can also be interpreted as a predictor, at least in the long run, of the different national inflation rates. However, in th...

  2. Chaotic inflation in supergravity

    CERN Document Server

    Kawasaki, M

    2001-01-01

    It is shown that chaotic inflation naturally takes place in the framework of supergravity if we assume hat the Kahler potential has a shift symmetry of the inflaton chiral multiplet and introduce a small breaking parameter.

  3. Inflatable traversing probe seal

    Science.gov (United States)

    Trimarchi, Paul A.

    1991-01-01

    An inflatable seal acts as a pressure-tight zipper to provide traversing capability for instrumentation rakes and probes. A specially designed probe segment with a teardrop cross-section in the vicinity of the inflatable seal minimizes leakage at the interface. The probe is able to travel through a lengthwise slot in a pressure vessel or wind tunnel section, while still maintaining pressure integrity. The design uses two commercially available inflatable seals, opposing each other, to cover the probe slot in a wind tunnel wall. Proof-of-concept tests were conducted at vessel pressures up to 30 psig, with seals inflated to 50 psig, showing no measurable leakage along the seal's length or around the probe teardrop cross-section. This seal concept can replace the existing technology of sliding face plate/O-ring systems in applications where lengthwise space is limited.

  4. No-Scale Inflation

    CERN Document Server

    Ellis, John; Nanopoulos, Dimitri V.; Olive, Keith A.

    2016-01-01

    Supersymmetry is the most natural framework for physics above the TeV scale, and the corresponding framework for early-Universe cosmology, including inflation, is supergravity. No-scale supergravity emerges from generic string compactifications and yields a non-negative potential, and is therefore a plausible framework for constructing models of inflation. No-scale inflation yields naturally predictions similar to those of the Starobinsky model based on $R + R^2$ gravity, with a tilted spectrum of scalar perturbations: $n_s \\sim 0.96$, and small values of the tensor-to-scalar perturbation ratio $r < 0.1$, as favoured by Planck and other data on the cosmic microwave background (CMB). Detailed measurements of the CMB may provide insights into the embedding of inflation within string theory as well as its links to collider physics.

  5. Inflation, its causes and consequences

    OpenAIRE

    Berezan, Elena

    2016-01-01

    The economic crisis has various negative consequences, among which there is a considerable growth of inflation. As a result the prices increase for different categories of goods and devalue the savings of the population in national currency. Managing inflation is a major problem for economic policy. To reduce the rate of inflation it is necessary to take measures for carrying out a wide complex of anti-inflation measures. The article describes the main reasons of inflation, highlights the soc...

  6. Natural double inflation

    Science.gov (United States)

    Occhionero, F.; Litterio, M.; Capozziello, S.; Amendola, L.

    The astronomical interest of double inflation stems from the possibility it gives of inserting a feature in an otherwise featureless (or scale invariant) perturbation spectrum, precisely at the scale (100 Mpc, say) that goes through the horizon at the (sharp) separations between the two successive inflations. Double inflation occurs when two scalar fields (or inflatons) dominate sequentially the cosmic expansion or when vacuum polarization — Ricci scalar R squared added to the Lagrangian — is taken into account and only one inflaton ψ is present. (This perhaps is more natural as it exploits quantum effects to reduce to one the number of the ad hoc ingredients.) In that case we know from Starobinsky's pioneering work that the first inflation is driven by R — rightly called then scalaron — under the rules of Fourth Order Gravity, (FOG), while the second is driven by ψ under the rules of ordinary General Relativity, (GR). Unfortunately most of the appeal of the scalaron-inflaton scenario in relation to the feature in the perturbation spectrum, is lost because a delicate fine tuning of the value of the (second) inflaton at the beginning of the second inflation is required, in the absence of which the two inflations merge in one and no scale is singled out. In order to overcome this difficulty, we introduce in the Lagrangian density a new scalar coupling between ψ and R2, analogous to the well known non minimal coupling between ψ and R of canonical GR. We show that in this way the two inflationary episodes of FOG and GR may be neatly distinguished from each other, regardless of the initial value of ψ. This is due to the influence of the coupling on the shape of the conformal potential, in which one can easily carve a channel of evolution, consisting in fact of two orthogonal valleys. Then, for most of phase space the attractor is this doubly inflationary trajectory that lies at the bottom of the two valleys (Fig. 1). In fact, in this case the Universe first

  7. Inflation and Wealth Distribution

    OpenAIRE

    Heer, Burkhard; Süssmuth, Bernd

    2003-01-01

    The effect of a permanent change of inflation on the distribution of wealth is analyzed in a general equilibrium OLG model that is calibrated with regard to the characteristics of the US economy. Poor agents accumulate savings predominantly in the form of money, while rich agents participate in the stock market and accumulate equity. Surprisingly, an increase of inflation results in a lower stock market participation rate; in addition, the distribution of wealth becomes more unequal, even tho...

  8. Initial conditions for inflation

    Science.gov (United States)

    Dimopoulos, Konstantinos; Artymowski, Michał

    2017-09-01

    Within the α-attractors framework we investigate scalar potentials with the same pole as the one featured in the kinetic term. We show that, in field space, this leads to directions without a plateau. Using this, we present a proposal, which manages to overcome the initial conditions problem of inflation with a plateau. An earlier period of proto-inflation, beginning at Planck scale, accounts for the Universe expansion and arranges the required initial conditions for inflation on the plateau to commence. We show that, if proto-inflation is power-law, it does not suffer from a sub-Planckian eternal inflationary stage, which would otherwise be a problem. A simple model realisation is constructed in the context of α-attractors, which can both generate the inflationary plateau and the exponential slopes around it, necessary for the two inflation stages. Our mechanism allows to assume chaotic initial conditions at the Planck scale for proto-inflation, it is generic and it is shown to work without fine-tuning.

  9. Technical Note: Does Core Inflation Help Forecast Total Inflation? Evidence from Colombia

    OpenAIRE

    John Thornton

    1998-01-01

    In Colombia core and total inflation are both (1) series, and core inflation is cointegrated with total inflation. Granger causality tests using error correction methodology indicate that divergence of total inflation from core inflation is quickly revers

  10. Perturbations in warm inflation

    Energy Technology Data Exchange (ETDEWEB)

    de Oliveira, H. P.; Joras, S. E.

    2001-09-15

    Warm inflation is an interesting possibility to describe the early universe, whose basic feature is the absence, at least in principle, of a preheating or reheating phase. Here we analyze the dynamics of warm inflation generalizing the usual slow-roll parameters that are useful for characterizing the inflationary phase. We study the evolution of entropy and adiabatic perturbations, where the main result is that for a very small amount of dissipation the entropy perturbations can be neglected and the purely adiabatic perturbations will be responsible for the primordial spectrum of inhomogeneities. Taking into account the Cosmic Background Explorer Differential Microwave Radiometer data of the cosmic microwave background anisotropy as well as the fact that the interval of inflation for which the scales of astrophysical interest cross outside the Hubble radius is about 50 e-folds before the end of inflation, we could estimate the magnitude of the dissipation term. It is also possible to show that at the end of inflation the universe is hot enough to provide a smooth transition to the radiation era.

  11. Quasi-open inflation

    CERN Document Server

    García-Bellido, J; Montes, X; Garcia-Bellido, Juan; Garriga, Jaume; Montes, Xavier

    1998-01-01

    We show that a large class of two-field models of single-bubble open inflation do not lead to infinite open universes, as it was previously thought, but to an ensemble of very large but finite inflating `islands'. The reason is that the quantum tunneling responsible for the nucleation of the bubble does not occur simultaneously along both field directions and equal-time hypersurfaces in the open universe are not synchronized with equal-density or fixed-field hypersurfaces. The most probable tunneling trajectory corresponds to a zero value of the inflaton field; large values, necessary for the second period of inflation inside the bubble, only arise as localized fluctuations. The interior of each nucleated bubble will contain an infinite number of such inflating regions of comoving size of order $\\gamma^{-1}$, where $\\gamma$ depends on the parameters of the model. Each one of these islands will be a quasi-open universe. Since the volume of the hyperboloid is infinite, inflating islands with all possible values...

  12. Inflation And Gravity Models

    CERN Document Server

    Solganik, S

    2005-01-01

    The thesis is devoted to a number of fundamental issues at the intersection of particle physics and cosmology. In particular, we invent one of the first models of the brane inflationary scenario in string theory, the so- called D-brane inflation. In this picture, the role of the inflation field is played by the brane-anti-brane separation. Branes are slowly attracted toward each other. During this slow motion, the potential energy of their tension causes the four-dimensional space to inflate. Inflation ends by the brane collision and annihilation, which reheats the Universe. Thus, in our picture inflation acquires a novel geometric meaning as seen from high-dimensional string theory. Another subject investigated in the thesis is the large distance modification of gravity, which is motivated by the observed mysterious accelerated expansion of the Universe. We study different aspects of the two possible approaches leading to modified gravity. One is Dvali- Gabadadze-Porrati (DGP) model, in which gravity gets mo...

  13. Minimal Composite Inflation

    DEFF Research Database (Denmark)

    Channuie, Phongpichit; Jark Joergensen, Jakob; Sannino, Francesco

    2011-01-01

    We investigate models in which the inflaton emerges as a composite field of a four dimensional, strongly interacting and nonsupersymmetric gauge theory featuring purely fermionic matter. We show that it is possible to obtain successful inflation via non-minimal coupling to gravity, and that the u......We investigate models in which the inflaton emerges as a composite field of a four dimensional, strongly interacting and nonsupersymmetric gauge theory featuring purely fermionic matter. We show that it is possible to obtain successful inflation via non-minimal coupling to gravity......, and that the underlying dynamics is preferred to be near conformal. We discover that the compositeness scale of inflation is of the order of the grand unified energy scale....

  14. Supersymmetry and Inflation

    CERN Document Server

    Sagnotti, A.

    2015-01-01

    Theories with elementary scalar degrees of freedom seem nowadays required for simple descriptions of the Standard Model and of the Early Universe. It is then natural to embed theories of inflation in supergravity, also in view of their possible ultraviolet completion in String Theory. After some general remarks on inflation in supergravity, we describe examples of minimal inflaton dynamics which are compatible with recent observations, including higher-curvature ones inspired by the Starobinsky model. We also discuss different scenarios for supersymmetry breaking during and after inflation, which include a revived role for non-linear realizations. In this spirit, we conclude with a discussion of the link, in four dimensions, between "brane supersymmetry breaking" and the super--Higgs effect in supergravity.

  15. Inflation Targeting: Provisional Results

    Directory of Open Access Journals (Sweden)

    Cerna, Silviu

    2010-06-01

    Full Text Available Inflation targeting monetary policy framework that requires the central bank to achieve a low inflation has contributed to price stability in industrialized countries. As well as the other developing countries, ex communist countries have also tried to apply this strategy, which was susceptible to increase monetary policy transparency and to determine authorities to make necessary reforms in order to pass from a planned to a market economy. In Romania, inflation targeting has contributed, to a large extent, to price increase smoothening, without affecting economic growth. Knowing the factors that have determined this unquestionable success allows for not only understanding the Romanian transition process, but also draw some useful conclusions in view of the necessary actions for adopting the euro.

  16. Inflatable Wing Deployment Sequence

    Science.gov (United States)

    2001-01-01

    The deployable, inflatable wing technology demonstrator aircraft's wings begin deploying following separation from its carrier aircraft during a flight experiment conducted by the NASA Dryden Flight Research Center, Edwards, California. Wing deployment time is typically on the order of a third of a second, almost faster than the human eye can see. Three successful flights of the I2000 inflatable wing aircraft occurred. During the flights, the team air-launched the radio-controlled (R/C) I2000 from an R/C utility airplane at an altitude of 800-1000 feet. As the I2000 separated from the carrier aircraft, its inflatable wings 'popped-out,' deploying rapidly via an on-board nitrogen bottle. The aircraft remained stable as it transitioned from wingless to winged flight. The unpowered I2000 glided down to a smooth landing under complete control.

  17. Flipped GUT inflation

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, John [Theoretical Particle Physics and Cosmology Group, Department of Physics, King' s College London, Strand, London WC2R 2LS (United Kingdom); Gonzalo, Tomás E.; Harz, Julia; Huang, Wei-Chih, E-mail: john.ellis@cern.ch, E-mail: tomas.gonzalo.11@ucl.ac.uk, E-mail: j.harz@ucl.ac.uk, E-mail: wei-chih.huang@ucl.ac.uk [Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT (United Kingdom)

    2015-03-01

    We analyse the prospects for constructing hybrid models of inflation that provide a dynamical realisation of the apparent closeness between the supersymmetric GUT scale and the possible scale of cosmological inflation. In the first place, we consider models based on the flipped SU(5)×U(1) gauge group, which has no magnetic monopoles. In one model, the inflaton is identified with a sneutrino field, and in the other model it is a gauge singlet. In both cases we find regions of the model parameter spaces that are compatible with the experimental magnitudes of the scalar perturbations, A{sub s}, and the tilt in the scalar perturbation spectrum, n{sub s}, as well as with an indicative upper limit on the tensor-to-scalar perturbation ratio, r. We also discuss embeddings of these models into SO(10), which is broken at a higher scale so that its monopoles are inflated away.

  18. Flipped GUT Inflation

    CERN Document Server

    Ellis, John; Harz, Julia; Huang, Wei-Chih

    2015-01-01

    We analyse the prospects for constructing hybrid models of inflation that provide a dynamical realisation of the apparent closeness between the supersymmetric GUT scale and the possible scale of cosmological inflation. In the first place, we consider models based on the flipped SU(5)$\\times$U(1) gauge group, which has no magnetic monopoles. In one model, the inflaton is identified with a sneutrino field, and in the other model it is a gauge singlet. In both cases we find regions of the model parameter spaces that are compatible with the experimental magnitudes of the scalar perturbations, $A_s$, and the tilt in the scalar perturbation spectrum, $n_s$, as well as with an indicative upper limit on the tensor-to-scalar perturbation ratio, $r$. We also discuss embeddings of these models into SO(10), which is broken at a higher scale so that its monopoles are inflated away.

  19. Flipped GUT inflation

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, John [Theoretical Particle Physics and Cosmology Group, Department of Physics, King’s College London, Strand, London WC2R 2LS (United Kingdom); Theory Division, CERN, Route de Meyrin 385, 1217 Meyrin (Switzerland); Gonzalo, Tomás E.; Harz, Julia; Huang, Wei-Chih [Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT (United Kingdom)

    2015-03-23

    We analyse the prospects for constructing hybrid models of inflation that provide a dynamical realisation of the apparent closeness between the supersymmetric GUT scale and the possible scale of cosmological inflation. In the first place, we consider models based on the flipped SU(5)×U(1) gauge group, which has no magnetic monopoles. In one model, the inflaton is identified with a sneutrino field, and in the other model it is a gauge singlet. In both cases we find regions of the model parameter spaces that are compatible with the experimental magnitudes of the scalar perturbations, A{sub s}, and the tilt in the scalar perturbation spectrum, n{sub s}, as well as with an indicative upper limit on the tensor-to-scalar perturbation ratio, r. We also discuss embeddings of these models into SO(10), which is broken at a higher scale so that its monopoles are inflated away.

  20. Supersymmetry and Inflation

    CERN Document Server

    Ferrara, Sergio

    2017-01-01

    Theories with elementary scalar degrees of freedom seem nowadays required for simple descriptions of the Standard Model and of the Early Universe. It is then natural to embed theories of inflation in supergravity, also in view of their possible ultraviolet completion in String Theory. After some general remarks on inflation in supergravity, we describe examples of minimal inflaton dynamics which are compatible with recent observations, including higher-curvature ones inspired by the Starobinsky model. We also discuss different scenarios for supersymmetry breaking during and after inflation, which include a revived role for non-linear realizations. In this spirit, we conclude with a discussion of the link, in four dimensions, between "brane supersymmetry breaking" and the super--Higgs effect in supergravity.

  1. Inflatable Dark Matter.

    Science.gov (United States)

    Davoudiasl, Hooman; Hooper, Dan; McDermott, Samuel D

    2016-01-22

    We describe a general scenario, dubbed "inflatable dark matter," in which the density of dark matter particles can be reduced through a short period of late-time inflation in the early Universe. The overproduction of dark matter that is predicted within many, otherwise, well-motivated models of new physics can be elegantly remedied within this context. Thermal relics that would, otherwise, be disfavored can easily be accommodated within this class of scenarios, including dark matter candidates that are very heavy or very light. Furthermore, the nonthermal abundance of grand unified theory or Planck scale axions can be brought to acceptable levels without invoking anthropic tuning of initial conditions. A period of late-time inflation could have occurred over a wide range of scales from ∼MeV to the weak scale or above, and could have been triggered by physics within a hidden sector, with small but not necessarily negligible couplings to the standard model.

  2. Exploring polyvinylpyrrolidone in the engineering of large porous PLGA microparticles via single emulsion method with tunable sustained release in the lung: In vitro and in vivo characterization.

    Science.gov (United States)

    Ni, Rui; Muenster, Uwe; Zhao, Jing; Zhang, Lan; Becker-Pelster, Eva-Maria; Rosenbruch, Martin; Mao, Shirui

    2017-03-10

    Sustained pulmonary drug delivery is regarded as an effective strategy for local treatment of chronic lung diseases. Despite of the progress made so far, there remains a need for respirable drug loaded porous microparticles, where porosity of the microparticles can be readily engineered during the preparation process, with tunable sustained drug release upon lung deposition. In this work, polyvinyl pyrrolidone (PVP) was used as a novel porogen to engineer PLGA-based large porous particles (LPPs) using single emulsion method, with fine tuning of the porosity, sustained drug release both in vitro and in vivo. Using cinaciguat as the model drug, influence of PVP content and PLGA type on the properties of the LPPs was characterized, including geometric particle size, drug encapsulation efficiency, tap density, theoretical and experimental aerodynamic particle size, specific surface area, morphology, and in vitro drug release. Solid state of cinaciguat in the LPPs was studied based on DSC and X-ray analysis. LPPs retention in the rat lung was carried out using bronchoalveolar lavage fluid method. Raw 264.7 macrophage cells were used for LPPs uptake study. Pharmacodynamic study was performed in mini-pigs in a well-established model of pulmonary arterial hypertension (thromboxane challenge). It was demonstrated that porosity of the LPPs is tunable via porogen content variation. Cinaciguat can be released from the LPP in a controlled manner for over 168h. Significant reduction of macrophage phagocytosis was presented for LPPs. Furthermore, LPPs was found to have extended retention time (~36h) in the rat lung and accordingly, sustained pharmacodynamics effect was achieved in mini-pig model. Taken together, our results demonstrated that this simple PLGA based LPPs engineering using single emulsion method with PVP as porogen may find extensive application for the pulmonary delivery of hydrophobic drugs to realize tunable sustained effect with good safety profile. Copyright

  3. Quintessential inflation: A unified scenario of inflation and dark energy

    Science.gov (United States)

    Hossain, Wali

    2018-01-01

    Quintessential inflation unifies inflation and late time acceleration by a single scalar field. Such a scenario, with canonical and non-canonical scalar fields, has been discussed. The scalar field behaves as an inflaton field during inflation and as a quintessence field during late time. Also the predictions of the models has been compared with the recent Planck data.

  4. Quintessential inflation: A unified scenario of inflation and dark energy

    Directory of Open Access Journals (Sweden)

    Hossain Wali

    2018-01-01

    Full Text Available Quintessential inflation unifies inflation and late time acceleration by a single scalar field. Such a scenario, with canonical and non-canonical scalar fields, has been discussed. The scalar field behaves as an inflaton field during inflation and as a quintessence field during late time. Also the predictions of the models has been compared with the recent Planck data.

  5. Inflation of a Polymeric Menbrane

    DEFF Research Database (Denmark)

    Kristensen, Susanne B.; Larsen, Johannes R.; Hassager, Ole

    1998-01-01

    We consider an axisymmetric polymeric membrane inflated by a uniform pressure difference acting across the membrane.......We consider an axisymmetric polymeric membrane inflated by a uniform pressure difference acting across the membrane....

  6. Administration of bleomycin via the oropharyngeal aspiration route leads to sustained lung fibrosis in mice and rats as quantified by UTE-MRI and histology.

    Directory of Open Access Journals (Sweden)

    Christine Egger

    Full Text Available Pulmonary fibrosis can be experimentally induced in small rodents by bleomycin. The antibiotic is usually administered via the intratracheal or intranasal routes. In the present study, we investigated the oropharyngeal aspiration of bleomycin as an alternative route for the induction of lung fibrosis in rats and mice. The development of lung injury was followed in vivo by ultrashort echo time magnetic resonance imaging (UTE-MRI and by post-mortem analyses (histology of collagen, hydroxyproline determination, and qRT-PCR. In C57BL/6 mice, oropharyngeal aspiration of bleomycin led to more prominent lung fibrosis as compared to intranasal administration. Consequently, the oropharyngeal aspiration route allowed a dose reduction of bleomycin and, therewith, a model refinement. Moreover, the distribution of collagen after oropharyngeal aspiration of bleomycin was more homogenous than after intranasal administration: for the oropharyngeal aspiration route, fibrotic areas appeared all over the lung lobes, while for the intranasal route fibrotic lesions appeared mainly around the largest superior airways. Thus, oropharyngeal aspiration of bleomycin induced morphological changes that were more comparable to the human disease than the intranasal administration route did. Oropharyngeal aspiration of bleomycin led to a homogeneous fibrotic injury also in rat lungs. The present data suggest oropharyngeal aspiration of bleomycin as a less invasive means to induce homogeneous and sustained fibrosis in the lungs of mice and rats.

  7. Administration of Bleomycin via the Oropharyngeal Aspiration Route Leads to Sustained Lung Fibrosis in Mice and Rats as Quantified by UTE-MRI and Histology

    Science.gov (United States)

    Egger, Christine; Cannet, Catherine; Gérard, Christelle; Jarman, Elizabeth; Jarai, Gabor; Feige, Agnès; Suply, Thomas; Micard, Arthur; Dunbar, Andrew; Tigani, Bruno; Beckmann, Nicolau

    2013-01-01

    Pulmonary fibrosis can be experimentally induced in small rodents by bleomycin. The antibiotic is usually administered via the intratracheal or intranasal routes. In the present study, we investigated the oropharyngeal aspiration of bleomycin as an alternative route for the induction of lung fibrosis in rats and mice. The development of lung injury was followed in vivo by ultrashort echo time magnetic resonance imaging (UTE-MRI) and by post-mortem analyses (histology of collagen, hydroxyproline determination, and qRT-PCR). In C57BL/6 mice, oropharyngeal aspiration of bleomycin led to more prominent lung fibrosis as compared to intranasal administration. Consequently, the oropharyngeal aspiration route allowed a dose reduction of bleomycin and, therewith, a model refinement. Moreover, the distribution of collagen after oropharyngeal aspiration of bleomycin was more homogenous than after intranasal administration: for the oropharyngeal aspiration route, fibrotic areas appeared all over the lung lobes, while for the intranasal route fibrotic lesions appeared mainly around the largest superior airways. Thus, oropharyngeal aspiration of bleomycin induced morphological changes that were more comparable to the human disease than the intranasal administration route did. Oropharyngeal aspiration of bleomycin led to a homogeneous fibrotic injury also in rat lungs. The present data suggest oropharyngeal aspiration of bleomycin as a less invasive means to induce homogeneous and sustained fibrosis in the lungs of mice and rats. PMID:23667616

  8. Topological defects in extended inflation

    Energy Technology Data Exchange (ETDEWEB)

    Copeland, E.J. (Department of Physics, University of Sussex, Brighton BN1 9QH (United Kingdom)); Kolb, E.W. (NASA/Fermilab Astrophysics Center, Fermi National Accelerator Laboratory, Batavia, IL (USA) Department of Astronomy and Astrophysics, Enrico Fermi Institute, The University of Chicago, Chicago, IL (USA)); Liddle, A.R. (Astronomy Centre, Department of Physics, University of Sussex, Brighton (United Kingdom))

    1990-10-15

    We consider the production of topological defects, especially cosmic strings, in extended-inflation models. In extended inflation, the Universe passes through a first-order phase transition via bubble percolation, which naturally allows defects to form at the end of inflation. The correlation length, which determines the number density of the defects, is related to the mean size of the bubbles when they collide. This mechanism allows a natural combination of inflation and large-scale structure via cosmic strings.

  9. Topological defects in extended inflation

    Energy Technology Data Exchange (ETDEWEB)

    Copeland, E.J. (Sussex Univ., Brighton (UK). Dept. of Physics); Kolb, E.W. (Fermi National Accelerator Lab., Batavia, IL (USA) Chicago Univ., IL (USA). Enrico Fermi Inst.); Liddle, A.R. (Sussex Univ., Brighton (UK). Astronomy Centre)

    1990-04-01

    We consider the production of topological defects, especially cosmic strings, in extended inflation models. In extended inflation, the Universe passes through a first-order phase transition via bubble percolation, which naturally allows defects to form at the end of inflation. The correlation length, which determines the number density of the defects, is related to the mean size of bubbles when they collide. This mechanism allows a natural combination of inflation and large-scale structure via cosmic strings. 18 refs.

  10. Hill-climbing Higgs inflation

    Science.gov (United States)

    Jinno, Ryusuke; Kaneta, Kunio; Oda, Kin-ya

    2018-01-01

    We propose a realization of cosmic inflation with the Higgs field when the Higgs potential has degenerate vacua by employing the recently proposed idea of hill-climbing inflation. The resultant inflationary predictions exhibit a sizable deviation from those of the ordinary Higgs inflation.

  11. Inflatable Column Structure

    Science.gov (United States)

    Hedgepeth, J. M.

    1985-01-01

    Lightweight structural member easy to store. Billowing between circumferential loops of fiber inflated column becomes series of cells. Each fiber subjected to same tension along entire length (though tension is different in different fibers). Member is called "isotensoid" column. Serves as jack for automobiles or structures during repairs. Also used as support for temporary bleachers or swimming pools.

  12. Testing Cosmic Inflation

    Science.gov (United States)

    Chuss, David

    2010-01-01

    The Cosmic Microwave Background (CMB) has provided a wealth of information about the history and physics of the early Universe. Much progress has been made on uncovering the emerging Standard Model of Cosmology by such experiments as COBE and WMAP, and ESA's Planck Surveyor will likely increase our knowledge even more. Despite the success of this model, mysteries remain. Currently understood physics does not offer a compelling explanation for the homogeneity, flatness, and the origin of structure in the Universe. Cosmic Inflation, a brief epoch of exponential expansion, has been posted to explain these observations. If inflation is a reality, it is expected to produce a background spectrum of gravitational waves that will leave a small polarized imprint on the CMB. Discovery of this signal would give the first direct evidence for inflation and provide a window into physics at scales beyond those accessible to terrestrial particle accelerators. I will briefly review aspects of the Standard Model of Cosmology and discuss our current efforts to design and deploy experiments to measure the polarization of the CMB with the precision required to test inflation.

  13. Hillclimbing saddle point inflation

    Science.gov (United States)

    Kawana, Kiyoharu; Sakai, Katsuta

    2018-03-01

    Recently a new inflationary scenario was proposed in [1] which can be applicable to an inflaton having multiple vacua. In this letter, we consider a more general situation where the inflaton potential has a (UV) saddle point around the Planck scale. This class of models can be regarded as a natural generalization of the hillclimbing Higgs inflation [2].

  14. Before primordial inflation

    Science.gov (United States)

    Nanopoulos, D. V.; Srednicki, M.

    1983-12-01

    We show that, before the onset of primordial inflation, there is plenty of time for fields with very flat potentials and very weak couplings (such as the local supersymmetry breaking field and the axion field) to roll to the global minima of their potentials. Thus there is no energy stored in these fields today and hence no constraint (such as faxion USA.

  15. Hilltop Supernatural Inflation

    Science.gov (United States)

    Lin, C.

    In this talk, I will explain how to reduce the spectral index to be n_s = 0.96 for supernatural inflation. I will also show the constraint to the reheating temperature from Big Bang Nucleosynthesis of both thermal and non-thermal gravitino production.

  16. Bispectrum from open inflation

    Science.gov (United States)

    Sugimura, Kazuyuki; Komatsu, Eiichiro

    2013-11-01

    We calculate the bispectrum of primordial curvature perturbations, ζ, generated during ``open inflation.'' Inflation occurs inside a bubble nucleated via quantum tunneling from the background false vacuum state. Our universe lives inside the bubble, which can be described as a Friedmann-Lemaȋtre-Robertson-Walker (FLRW) universe with negative spatial curvature, undergoing slow-roll inflation. We pay special attention to the issue of an initial state for quantum fluctuations. A ``vacuum state'' defined by a positive-frequency mode in de Sitter space charted by open coordinates is different from the Euclidean vacuum (which is equivalent to the so-called ``Bunch-Davies vacuum'' defined by a positive-frequency mode in de Sitter space charted by flat coordinates). Quantum tunneling (bubble nucleation) then modifies the initial state away from the original Euclidean vacuum. While most of the previous study on modifications of the initial quantum state introduces, by hand, an initial time at which the quantum state is modified as well as the form of the modification, an effective initial time naturally emerges and the form is fixed by quantum tunneling in open inflation models. Therefore, open inflation enables a self-consistent computation of the effect of a modified initial state on the bispectrum. We find a term which goes as langleζk1ζk2ζk3ranglepropto1/k12k34 in the so-called squeezed configurations, k3 << k1 ≈ k2, in agreement with the previous study on modifications of the initial state. The bispectrum in the exact folded limit, e.g., k1 = k2+k3, is also enhanced and remains finite. However, these terms are exponentially suppressed when the wavelength of ζ is smaller than the curvature radius of the universe. The leading-order bispectrum is equal to the usual one from single-field slow-roll inflation; the terms specific for open inflation arise only in the sub-leading order when the wavelength of ζ is smaller than the curvature radius.

  17. Inflation and Inflation Uncertainty Revisited: Evidence from Egypt

    Directory of Open Access Journals (Sweden)

    Mesbah Fathy Sharaf

    2015-07-01

    Full Text Available The welfare costs of inflation and inflation uncertainty are well documented in the literature and empirical evidence on the link between the two is sparse in the case of Egypt. This paper investigates the causal relationship between inflation and inflation uncertainty in Egypt using monthly time series data during the period January 1974–April 2015. To endogenously control for any potential structural breaks in the inflation time series, Zivot and Andrews (2002 and Clemente–Montanes–Reyes (1998 unit root tests are used. The inflation–inflation uncertainty relation is modeled by the standard two-step approach as well as simultaneously using various versions of the GARCH-M model to control for any potential feedback effects. The analyses explicitly control for the effect of the Economic Reform and Structural Adjustment Program (ERSAP undertaken by the Egyptian government in the early 1990s, which affected inflation rate and its associated volatility. Results show a high degree of inflation–volatility persistence in the response to inflationary shocks. Granger-causality test along with symmetric and asymmetric GARCH-M models indicate a statistically significant bi-directional positive relationship between inflation and inflation uncertainty, supporting both the Friedman–Ball and the Cukierman–Meltzer hypotheses. The findings are robust to the various estimation methods and model specifications. The findings of this paper support the view of adopting inflation-targeting policy in Egypt, after fulfilling its preconditions, to reduce the welfare cost of inflation and its related uncertainties. Monetary authorities in Egypt should enhance the credibility of monetary policy and attempt to reduce inflation uncertainty, which will help lower inflation rates.

  18. Measures in Mutlifield Inflation

    CERN Document Server

    Grumitt, Richard

    2016-01-01

    We examine the classical dynamics of multifield inflation models with quadratic potentials. Such models are shown to have inflationary attractors in phase space, consistent with the stretching of phase space trajectories along the volume factor of the universe during inflation. Using the symplectic structure associated with Hamiltonian systems we form a measure on the phase space, as initially proposed by Gibbons, Hawking and Stewart. This is used to calculate lower bounds on the probabilities of observational agreement (i.e. the probability the model gives a value for the spectral index within the region $n_{s}=0.968\\pm{0.006}$) for equal mass two and three field models with quadratic potentials, giving values of 0.982 and 0.997 respectively. We derive the measure for a general $N$-field model and argue that as the number of fields approaches infinity, the probability of observational agreement approaches one.

  19. The Primordial Inflation Explorer

    Science.gov (United States)

    Kogut, Alan J.

    2012-01-01

    The Primordial Inflation Explorer is an Explorer-class mission to measure the gravity-wave signature of primordial inflation through its distinctive imprint on the linear polarization of the cosmic microwave background. PIXIE uses an innovative optical design to achieve background-limited sensitivity in 400 spectral channels spanning 2.5 decades in frequency from 30 GHz to 6 THz (1 cm to 50 micron wavelength). The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r < 10(exp -3) at 5 standard deviations. The rich PIXIE data set will also constrain physical processes ranging from Big Bang cosmology to the nature of the first stars to physical conditions within the interstellar medium of the Galaxy. I describe the PIXIE instrument and mission architecture needed to detect the inflationary signature using only 4 semiconductor bolometers.

  20. Inflation After Preheating

    CERN Document Server

    Felder, G; Linde, Andrei D; Tkachev, Igor I; Felder, Gary; Kofman, Lev; Linde, Andrei; Tkachev, Igor

    2000-01-01

    Preheating after inflation may lead to nonthermal phase transitions with symmetry restoration. These phase transitions may occur even if the total energy density of fluctuations produced during reheating is relatively small as compared with the vacuum energy in the state with restored symmetry. As a result, in some inflationary models one encounters a secondary, nonthermal stage of inflation due to symmetry restoration after preheating. We review the theory of nonthermal phase transitions and make a prediction about the expansion factor during the secondary inflationary stage. We then present the results of lattice simulations which verify these predictions, and discuss possible implications of our results for the theory of formation of topological defects during nonthermal phase transitions.

  1. Higgs scalaron mixed inflation

    Directory of Open Access Journals (Sweden)

    Yohei Ema

    2017-07-01

    Full Text Available We discuss the inflationary dynamics of a system with a non-minimal coupling between the Higgs and the Ricci scalar as well as a Ricci scalar squared term. There are two scalar modes in this system, i.e. the Higgs and the spin-zero mode of the graviton, or the scalaron. We study the two-field dynamics of the Higgs and the scalaron during inflation, and clarify the condition where inflation is dominated by the Higgs/scalaron. We also find that the cut-off scale at around the vacuum is as large as the Planck scale, and hence there is no unitarity issue, although there is a constraint on the couplings from the perturbativity of the theory at around the vacuum.

  2. Sneutrino inflation in GUTs

    Energy Technology Data Exchange (ETDEWEB)

    Antusch, Stefan; Baumann, Jochen P.; Dutta, Koushik; Kostka, Philipp M. [Max-Planck-Institut fuer Physik (Werner-Heisenberg-Institut), Muenchen (Germany); Bastero-Gil, Mar [Departamento de Fisica Teorica y del Cosmos, Centro Andaluz de Fisica de Particulas Elementales, Universidad de Granada, Granada (Spain); King, Steve F. [School of Physics and Astronomy, University of Southampton, Southampton (United Kingdom)

    2010-07-01

    We discuss sneutrino inflation in SUSY GUTs, in particular in Pati-Salam and SO(10). Since under these gauge groups the right-handed sneutrino is no longer a singlet, several problems arise. Not being a singlet, the scalar potential of the sneutrino in general receives large D-term contributions, which would violate the slow-roll conditions. Furthermore, with a charged inflaton problematic effects at the one- and two-loop level might arise, which again threaten the flatness of the potential. Additionally the problem of the production of stable topologic defects has to be addressed. We present a simple model of sneutrino inflation in Pati-Salam and discuss the aforementioned problems in this framework. Furthermore, we discuss the prospects of embedding such a model into SO(10).

  3. Inflation in the universe

    Energy Technology Data Exchange (ETDEWEB)

    Turner, M.S.

    1987-05-01

    The hot big bang cosmology, or the standard cosmology as it is appropriately known, is a highly successful model, providing a reliable and tested accounting of the Universe from 0.01 sec after the bang until today, some 15 Gyr later. However, very special initial data seem to be required in order to account for the observed smoothness and flatness of our Hubble volume and for the existence of the small primeval density inhomogeneities required for the formation of structure in the Universe. Inflation offers a means of accounting for these special initial data, which is based upon physics at sub-planck energy scales (<< m/sub pl/ approx. = 10/sup 19/ GeV) and is motivated by contemporary ideas in particle theory. Here I review the status of the 'Inflationary Paradigm'. At present essentially all inflationary models involve a very weakly-coupled (quantified by the presence of a dimensionless parameter of order 10/sup -12/ or so) scalar field which is displaced from the minimum of its potential. Regions of the Universe where the scalar field is initially displaced from its minimum undergo inflation as the scalar field relaxes, resulting in a Universe today which resembles ours in regions much larger than our present Hubble volume (approx. = 10/sup 28/ cm), but which on very large scales (>> 10/sup 28/ cm) may be highly irregular. The most conspicuous blemish on the paradigm is the lack of a compelling particle physics model to implement it. I also review some other unresolved issues, and discuss in detail the all important confrontation between inflation and observational data. Finally, I discuss the possibility that inflation leads to large-scale, primeval magnetic fields of sufficient strength to be of astrophysical interest. 123 refs., 4 figs.

  4. Is inflation natural

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, L.G.; Stein-Schabes, J.A.

    1987-02-15

    We show that under very general conditions any inhomogeneous cosmological model with a positive cosmological constant that can be described in a synchronous reference system will tend asymptotically in time towards the de Sitter solution, so making the problem of initial conditions less severe. The implications for inflationary scenarios are examined, and it is found that after inflation the Universe stays isotropic and homogeneous for a very long time.

  5. Gravitational waves from inflation

    Science.gov (United States)

    Guzzetti, M. C.; Bartolo, N.; Liguori, M.; Matarrese, S.

    2016-09-01

    The production of a stochastic background of gravitational waves is a fundamental prediction of any cosmological inflationary model. The features of such a signal encode unique information about the physics of the Early Universe and beyond, thus representing an exciting, powerful window on the origin and evolution of the Universe. We review the main mechanisms of gravitational-wave production, ranging from quantum fluctuations of the gravitational field to other mechanisms that can take place during or after inflation. These include e.g. gravitational waves generated as a consequence of extra particle production during inflation, or during the (p)reheating phase. Gravitational waves produced in inflation scenarios based on modified gravity theories and second-order gravitational waves are also considered. For each analyzed case, the expected power spectrum is given. We discuss the discriminating power among different models, associated with the validity/violation of the standard consistency relation between tensor-to-scalar ratio r and tensor spectral index nT. In light of the prospects for (directly/indirectly) detecting primordial gravitational waves, we give the expected present-day gravitational radiation spectral energy-density, highlighting the main characteristics imprinted by the cosmic thermal history, and we outline the signatures left by gravitational waves on the Cosmic Microwave Background and some imprints in the Large-Scale Structure of the Universe. Finally, current bounds and prospects of detection for inflationary gravitational waves are summarized.

  6. New Old Inflation

    Energy Technology Data Exchange (ETDEWEB)

    Dvali, Gia

    2003-10-03

    We propose a new class of inflationary solutions to the standard cosmological problems (horizon, flatness, monopole,...), based on a modification of old inflation. These models do not require a potential which satisfies the normal inflationary slow-roll conditions. Our universe arises from a single tunneling event as the inflaton leaves the false vacuum. Subsequent dynamics (arising from either the oscillations of the inflaton field or thermal effects) keep a second field trapped in a false minimum, resulting in an evanescent period of inflation (with roughly 50 e-foldings) inside the bubble. This easily allows the bubble to grow sufficiently large to contain our present horizon volume. Reheating is accomplished when the inflaton driving the last stage of inflation rolls down to the true vacuum, and adiabatic density perturbations arise from moduli-dependent Yukawa couplings of the inflaton to matter fields. Our scenario has several robust predictions, including virtual absence of gravity waves, a possible absence of tilt in scalar perturbations, and a higher degree of non-Gaussianity than other models. It also naturally incorporates a solution to the cosmological moduli problem.

  7. Inflation and the Higgs Scalar

    Energy Technology Data Exchange (ETDEWEB)

    Green, Dan [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2014-12-05

    This note makes a self-contained exposition of the basic facts of big bang cosmology as they relate to inflation. The fundamental problems with that model are then explored. A simple scalar model of inflation is evaluated which provides the solution of those problems and makes predictions which will soon be definitively tested. The possibility that the recently discovered fundamental Higgs scalar field drives inflation is explored.

  8. Stability of compactification during inflation

    Energy Technology Data Exchange (ETDEWEB)

    Amendola, L.; Litterio, M.; Occhionero, F. (Osservatorio Astronomico, Rome (Italy)); Kolb, E.W. (Osservatorio Astronomico, Rome (Italy) Fermi National Accelerator Lab., Batavia, IL (USA) Chicago Univ., IL (USA))

    1990-03-01

    The possibility that inflation may trigger an instability in compactification of extra spatial dimensions is considered. In old, new, or extended inflation, the false vacuum energy results in a semiclassical instability in which the scalar field representing the radius of the extra dimensions may tunnel through a potential barrier leading to an expansion of the internal space. In chaotic inflation, if the initial value of the scalar field responsible for inflation is large enough, the internal space becomes classically unstable to ever increasing expansion. Restrictions on inflationary models necessary to keep the extra dimensions small are discussed. 15 refs., 5 figs.

  9. A critical review of inflation

    CERN Document Server

    Turok, N G

    2002-01-01

    The theory of cosmic inflation offers an attractive resolution of some of the great paradoxes in cosmology: why the universe is so large, flat and uniform on large scales, and how density variations arose. Inflation has rightly dominated cosmological thinking for the past two decades, helping stimulate the development of high-precision observational programmes. The survival of simple inflationary models in the face of an impressive observational onslaught has been interpreted as convincing evidence of the correctness of the basic idea. In this paper, I review inflation, but highlight its weaknesses, explaining my reasons for believing that a more complete theory may supersede inflation without necessarily incorporating it.

  10. Assessing inflation persistence: micro evidence on an inflation targeting economy

    Czech Academy of Sciences Publication Activity Database

    Babecký, Jan; Coricelli, F.; Horváth, R.

    -, č. 353 (2008), s. 1-37 ISSN 1211-3298 Institutional research plan: CEZ:AV0Z70850503 Keywords : inflation dynamics * persistence * inflation targeting Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp353.pdf

  11. News on inflation and the epidemiology of inflation expectations

    NARCIS (Netherlands)

    Pfajfar, D.; Santoro, E.

    2013-01-01

    This paper examines the nexus between news coverage on inflation and households’ inflation expectations. In doing so, we test the epidemiological foundations of the sticky information model (Carroll 2003, 2006). We use both aggregate and household-level data from the Survey Research Center at the

  12. Inflation targeting and inflation performance : a comparative analysis

    NARCIS (Netherlands)

    Samarina, Anna; De Haan, Jakob; Terpstra, M.

    2014-01-01

    This article examines how the impact of inflation targeting on inflation performance depends on the choice of country samples, adoption dates, time periods and methodological approaches. We apply two different estimation methods - difference-in-differences and propensity score matching - for our

  13. News on Inflation and the Epidemiology of Inflation Expectations

    NARCIS (Netherlands)

    Pfajfar, D.; Santoro, E.

    2012-01-01

    Abstract: This paper examines the nexus between news coverage on inflation and households' inflation expectations. In doing so, we test the epidemiological foundations of the sticky information model (Carroll, 2003, 2006). We use both aggregate and household-level data from the Survey Research

  14. Volume-controlled Ventilation Does Not Prevent Injurious Inflation during Spontaneous Effort.

    Science.gov (United States)

    Yoshida, Takeshi; Nakahashi, Susumu; Nakamura, Maria Aparecida Miyuki; Koyama, Yukiko; Roldan, Rollin; Torsani, Vinicius; De Santis, Roberta R; Gomes, Susimeire; Uchiyama, Akinori; Amato, Marcelo B P; Kavanagh, Brian P; Fujino, Yuji

    2017-09-01

    Spontaneous breathing during mechanical ventilation increases transpulmonary pressure and Vt, and worsens lung injury. Intuitively, controlling Vt and transpulmonary pressure might limit injury caused by added spontaneous effort. To test the hypothesis that, during spontaneous effort in injured lungs, limitation of Vt and transpulmonary pressure by volume-controlled ventilation results in less injurious patterns of inflation. Dynamic computed tomography was used to determine patterns of regional inflation in rabbits with injured lungs during volume-controlled or pressure-controlled ventilation. Transpulmonary pressure was estimated by using esophageal balloon manometry [Pl(es)] with and without spontaneous effort. Local dependent lung stress was estimated as the swing (inspiratory change) in transpulmonary pressure measured by intrapleural manometry in dependent lung and was compared with the swing in Pl(es). Electrical impedance tomography was performed to evaluate the inflation pattern in a larger animal (pig) and in a patient with acute respiratory distress syndrome. Spontaneous breathing in injured lungs increased Pl(es) during pressure-controlled (but not volume-controlled) ventilation, but the pattern of dependent lung inflation was the same in both modes. In volume-controlled ventilation, spontaneous effort caused greater inflation and tidal recruitment of dorsal regions (greater than twofold) compared with during muscle paralysis, despite the same Vt and Pl(es). This was caused by higher local dependent lung stress (measured by intrapleural manometry). In injured lungs, esophageal manometry underestimated local dependent pleural pressure changes during spontaneous effort. Limitation of Vt and Pl(es) by volume-controlled ventilation could not eliminate harm caused by spontaneous breathing unless the level of spontaneous effort was lowered and local dependent lung stress was reduced.

  15. Dissipative Axial Inflation

    CERN Document Server

    Notari, Alessio

    2016-12-22

    We analyze in detail the background cosmological evolution of a scalar field coupled to a massless abelian gauge field through an axial term $\\frac{\\phi}{f_\\gamma} F \\tilde{F}$, such as in the case of an axion. Gauge fields in this case are known to experience tachyonic growth and therefore can backreact on the background as an effective dissipation into radiation energy density $\\rho_R$, which which can lead to inflation without the need of a flat potential. We analyze the system, for momenta $k$ smaller than the cutoff $f_\\gamma$, including numerically the backreaction. We consider the evolution from a given static initial condition and explicitly show that, if $f_\\gamma$ is smaller than the field excursion $\\phi_0$ by about a factor of at least ${\\cal O} (20)$, there is a friction effect which turns on before that the field can fall down and which can then lead to a very long stage of inflation with a generic potential. In addition we find superimposed oscillations, which would get imprinted on any kind of...

  16. Minimal Higgs inflation

    Directory of Open Access Journals (Sweden)

    Debaprasad Maity

    2017-06-01

    Full Text Available In this paper we propose minimal Higgs inflation scenarios by non-polynomial modification of the Higgs potential. The modification is done in such a way that it creates a flat plateau for a huge range of field values at the inflationary energy scale μ≃(λ1/4α. Assuming the perturbative Higgs quartic coupling, λ≃O(1, our model prediction for all the cosmologically relevant quantities, (ns,r,dnsk, fit extremely well with observations made by PLANCK. For both the models the inflation energy scale turned out to be μ≃(1014,1015 GeV. Considering observed central value of the scalar spectral index, ns=0.968, models predict efolding number, N=(52,47. Within a wide range of viable parameter space, we found that the prediction of tensor to scalar ratio r(≤10−5 is far below the current experimental limit. The prediction for the running of scalar spectral index, dnsk, remains very small. We also computed the background field dependent unitarity scale Λ(h, which turned out to be much larger than the aforementioned inflationary energy scale.

  17. Holography of Little Inflation

    Directory of Open Access Journals (Sweden)

    Brett McInnes

    2015-05-01

    Full Text Available For several crucial microseconds of its early history, the Universe consisted of a Quark–Gluon Plasma. As it cooled during this era, it traced out a trajectory in the quark matter phase diagram. The form taken by this trajectory is not known with certainty, but is of great importance: it determines, for example, whether the cosmic plasma passed through a first-order phase change during the transition to the hadron era, as has recently been suggested by advocates of the “Little Inflation” model. Just before this transition, the plasma was strongly coupled and therefore can be studied by holographic techniques. We show that holography imposes a strong constraint (taking the form of a bound on the baryonic chemical potential relative to the temperature on the domain through which the cosmic plasma could pass as it cooled, with important consequences for Little Inflation. In fact, we find that holography applied to Little Inflation implies that the cosmic plasma must have passed quite close to the quark matter critical point, and might therefore have been affected by the associated fluctuation phenomena.

  18. Forecasting Interest Rates and Inflation

    DEFF Research Database (Denmark)

    Chun, Albert Lee

    the best overall for short horizon forecasts of short to medium term yields and inflation. Econometric models with shrinkage perform the best over longer horizons and maturities. Aggregating over a larger set of analysts improves inflation surveys while generally degrading interest rates surveys. We...

  19. Regional Inflation and Financial Dollarization

    NARCIS (Netherlands)

    Brown, M.; de Haas, R.; Sokolov, V.

    2013-01-01

    Abstract: We exploit variation in consumer price inflation across 71 Russian regions to examine the relationship between the perceived stability of the local currency and financial dollarization. Our results show that regions with higher inflation experience an increase in the dollarization of

  20. Inflation differentials among Czech households

    Czech Academy of Sciences Publication Activity Database

    Janský, Petr; Hait, Pavel

    2016-01-01

    Roč. 25, č. 1 (2016), s. 71-84 ISSN 1210-0455 R&D Projects: GA TA ČR(CZ) TD020188 Institutional support: RVO:67985998 Keywords : households * inflation * inflation differentials Subject RIV: AH - Economics Impact factor: 0.710, year: 2016

  1. Testing inflation: a bootstrap approach.

    Science.gov (United States)

    Boyle, Latham; Steinhardt, Paul J

    2010-12-10

    We note that the essential idea of inflation, that the Universe underwent a brief period of accelerated expansion followed by a long period of decelerated expansion, can be encapsulated in a "closure condition" which relates the amount of accelerated expansion during inflation to the amount of decelerated expansion afterward. We present a protocol for systematically testing the validity of this condition observationally.

  2. Inflation accounting at international level

    Directory of Open Access Journals (Sweden)

    Suciu, G.

    2011-01-01

    Full Text Available The inflation’s influence on monetary and non-monetary elements, on the capital and on the account of profit and damage, leads to the adoption of norms, both at a national and international level, which would attenuate the effects of inflation. The economic, political and social particularities determine the implementation of some procedures for adapting of inflation accounting.

  3. Hypersonic Inflatable Aerodynamic Decelerator (HIAD) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Hypersonic Inflatable Aerodynamic Decelerator (HIAD) project will focus on the development and demonstration of hypersonic inflatable aeroshell technologies...

  4. Towards Inflation in String Theory

    Energy Technology Data Exchange (ETDEWEB)

    Kachru, Shamit

    2003-08-25

    We investigate the embedding of brane inflation into stable compactifications of string theory. At first sight a warped compactification geometry seems to produce a naturally flat inflation potential, evading one well-known difficulty of brane-antibrane scenarios. Careful consideration of the closed string moduli reveals a further obstacle: superpotential stabilization of the compactification volume typically modifies the inflation potential and renders it too steep for inflation. We discuss the non-generic conditions under which this problem does not arise. We conclude that brane inflation models can only work if restrictive assumptions about the method of volume stabilization, the warping of the internal space, and the source of inflationary energy are satisfied. We argue that this may not be a real problem, given the large range of available fluxes and background geometries in string theory.

  5. Inflation from field theory and string theory perspectives. Matter inflation and slow-walking inflation

    Energy Technology Data Exchange (ETDEWEB)

    Halter, Sebastian

    2012-07-09

    This thesis is concerned with aspects of inflation both from a field theory and a string theory perspective. It aims at exploring new approaches to address the problem of moduli destabilization and the η-problem and to realize inflation in the matter sector. The first part is devoted to studying models of inflation in the framework of four-dimensional N=1 supergravity. We begin with investigating a new proposal to solve the problem of moduli destabilization, which seems to force us to choose between low-energy supersymmetry and high-scale inflation. This new approach is based on a particular way to couple the modulus to the F-term driving inflation. Using chaotic inflation with a shift symmetry as an example, we show that we can successfully combine low-energy supersymmetry and high-scale inflation. We construct a class of inflation models in N=1 supergravity where the inflaton resides in gauge non-singlet matter fields. These are extensions of a special class of hybrid inflation models, so-called tribrid inflation, where the η-problem can be solved by a Heisenberg symmetry. Compared to previously studied models, we have generalized our models with some inspiration from string theory. We investigate moduli stabilization during inflation and identify situations in which the inflaton slope is dominated by radiative corrections. We outline under which conditions this class of matter inflation models could be embedded into heterotic orbifold compactifications. In doing so, we suggest a new mechanism to stabilize some Kaehler moduli by F-terms for matter fields. In the second part, we consider models of warped D-brane inflation on a family of ten-dimensional supergravity backgrounds. We consider inflation along the radial direction near the tip of the warped throat and show that generically an inflection point arises for the inflaton potential, which is related to an inflection point of the dilaton profile. A universal scaling behaviour with the parameters of the

  6. News on Inflation and the Epidemiology of Inflation Expectations

    DEFF Research Database (Denmark)

    Pfajfar, Damjan; Santoro, Emiliano

    2013-01-01

    This paper examines the nexus between news coverage on inflation and households’ inflation expectations. In doing so, we test the epidemiological foundations of the sticky information model (Carroll ). We use both aggregate and household-level data from the Survey Research Center at the University...... of Michigan. We highlight a fundamental disconnection among news on inflation, consumers’ frequency of expectation updating, and the accuracy of their expectations. Our evidence provides at best weak support to the epidemiological framework, as most of the consumers who update their expectations do not revise...

  7. Inflation from Minkowski space

    Energy Technology Data Exchange (ETDEWEB)

    Pirtskhalava, David; Santoni, Luca [Scuola Normale Superiore,Piazza dei Cavalieri 7, 56126, Pisa (Italy); Trincherini, Enrico [Scuola Normale Superiore,Piazza dei Cavalieri 7, 56126, Pisa (Italy); INFN - Sezione di Pisa,56100 Pisa (Italy); Uttayarat, Patipan [Department of Physics, University of Cincinnati,Cincinnati, OH 45220 (United States); Department of Physics, Srinakharinwirot University,Wattana, Bangkok 10110 (Thailand)

    2014-12-23

    We propose a class of scalar models that, once coupled to gravity, lead to cosmologies that smoothly and stably connect an inflationary quasi-de Sitter universe to a low, or even zero-curvature, maximally symmetric spacetime in the asymptotic past, strongly violating the null energy condition ( H-dot ≫H{sup 2}) at intermediate times. The models are deformations of the conformal galileon lagrangian and are therefore based on symmetries, both exact and approximate, that ensure the quantum robustness of the whole picture. The resulting cosmological backgrounds can be viewed as regularized extensions of the galilean genesis scenario, or, equivalently, as ‘early-time-complete’ realizations of inflation. The late-time inflationary dynamics possesses phenomenologically interesting properties: it can produce a large tensor-to-scalar ratio within the regime of validity of the effective field theory and can lead to sizeable equilateral nongaussianities.

  8. Quantum quenches during inflation

    Science.gov (United States)

    Carrilho, Pedro; Ribeiro, Raquel H.

    2017-02-01

    We propose a new technique to study fast transitions during inflation, by studying the dynamics of quantum quenches in an O (N ) scalar field theory in de Sitter spacetime. We compute the time evolution of the system using a nonperturbative large-N limit approach. We derive the self-consistent mass equation for several physically relevant transitions of the parameters of the theory, in a slow motion approximation. Our computations reveal that the effective mass after the quench evolves in the direction of recovering its value before the quench, but stopping at a different asymptotic value, in which the mass squared is strictly positive. Furthermore, we tentatively find situations in which the effective mass squared can be temporarily negative, thus breaking the O (N ) symmetry of the system for a certain time, only to then come back to a positive value, restoring the symmetry. We argue the relevance of our new method in a cosmological scenario.

  9. Manyfield inflation in random potentials

    Science.gov (United States)

    Bjorkmo, Theodor; Marsh, M. C. David

    2018-02-01

    We construct models of inflation with many randomly interacting fields and use these to study the generation of cosmological observables. We model the potentials as multi-dimensional Gaussian random fields (GRFs) and identify powerful algebraic simplifications that, for the first time, make it possible to access the manyfield limit of inflation in GRF potentials. Focussing on small-field, slow-roll, approximate saddle-point inflation in potentials with structure on sub-Planckian scales, we construct explicit examples involving up to 100 fields and generate statistical ensembles comprising of 164,000 models involving 5 to 50 fields. For the subset of these that support at least sixty e-folds of inflation, we use the 'transport method' and δ N formalism to determine the predictions for cosmological observables at the end of inflation, including the power spectrum and the local non-Gaussianities of the primordial perturbations. We find three key results: i) Planck compatibility is not rare, but future experiments may rule out this class of models; ii) In the manyfield limit, the predictions from these models agree well with, but are sharper than, previous results derived using potentials constructed through non-equilibrium Random Matrix Theory; iii) Despite substantial multifield effects, non-Gaussianities are typically very small: fNLloc ll 1. We conclude that many of the 'generic predictions' of single-field inflation can be emergent features of complex inflation models.

  10. Inflatable Personal Flotation Device Study.

    Science.gov (United States)

    1981-02-01

    late. t, h Iw . No cood (1) - CVider would not Ipu, tore 1t) - ( I\\ inder d idn ’t punk t n- t . Tried several times. Lost belt in lake, Lr ic - caIIt...dii not respond as expected (1) 6. (C) - When C02 cylinder is used to inflate, all the snaps do not pop open (1) - No event (1) - When inflated it is...Upon inflation, the snap closest to my face popped , striking my hand and face (1) - Device rode up over back of head in rough water (1) - None (1

  11. Higgs Inflation as a Mirage

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    After reviewing the nice properties of Higgs inflation and some of its problems, I will discuss a simple unitarization of the scenario that is genuinely weakly coupled up to Planckian energies. A large non-minimal coupling between the Higgs and the Ricci curvature is induced dynamically at intermediate energies, as a simple ratio of mass scales. Inflationary dynamics is not dominated by the Higgs field, but 'Higgs inflation' arises as an approximate 'mirage' picture of the true dynamics. I will speculate on the generality of this phenomenon and show that, if Higgs-inflation arises as an effective description, the details of the UV completion are necessary to extract robust quantitative predictions.

  12. Supernatural A-term Inflation

    OpenAIRE

    Lin, Chia-Min; Cheung, Kingman

    2009-01-01

    Following \\cite{Lin:2009yt}, we explore the parameter space of the case when the supersymmetry (SUSY) breaking scale is lower, for example, in gauge mediated SUSY breaking model. During inflation, the form of the potential is $V_0$ plus MSSM (MSSM stands for Minimal Supersymmetric Standard Model) (or A term (It is called A-term inflation when the inflaton field is any direction (gauge or singlet) that generates an A-term.)) inflation. We show that the model works for a wide range of the poten...

  13. 12 CFR 19.240 - Inflation adjustments.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount... Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note) as follows: ER10NO08.001 (b) The...

  14. Assessing inflation persistence: micro evidence on an inflation targeting economy

    Czech Academy of Sciences Publication Activity Database

    Babecký, Jan; Coricelli, F.; Horváth, R.

    2009-01-01

    Roč. 59, č. 2 (2009), s. 102-127 ISSN 0015-1920 Grant - others:Česká národní banka(CZ) E5/05 Institutional research plan: CEZ:AV0Z70850503 Keywords : inflation dynamics * persistence * inflation targeting Subject RIV: AH - Economics Impact factor: 0.264, year: 2009 http://journal.fsv.cuni.cz/storage/1153_babeck%C3%BD_horv%C3%A1th_coricelli.pdf

  15. Relevance of Low Inflation in the Southeastern European Countries

    Directory of Open Access Journals (Sweden)

    Lakić Slobodan

    2016-05-01

    Full Text Available The paper starts from the assumption that the significant reduction of the inflation problem is a result of the long-term dynamics of economic growth in countries with developing markets and, as a result, operational inability of multinational companies to increase accumulation through the policy of raising prices by creating space for their full expansion. We believe that in such circumstances civil theories on the causes of inflation are dominantly of class character. We check negative repercussions of low inflation on the examples of the countries of South-East Europe, in the regimes with fixed and flexible exchange rates, and with different strategies of monetary policy. We conclude that destructive implications of the financial crisis and psychological factors have a negative impact on a sustainable low-inflation environment, regardless of the monetary-exchange regime. We propose that low and stable inflation rates can be followed by a series of negative implications for the overall economic system, which our analysis of the observed countries proves.

  16. Consumer's inflation expectations in Brazil

    Directory of Open Access Journals (Sweden)

    Fernando Ormonde Teixeira

    Full Text Available Abstract This paper investigates what are the main components of consumer's inflation expectations. We combine the FGV's Consumer Survey with the indices of inflation (IPCA and government regulated prices, professional forecasts disclosed in the Focus report, and media data which we crawl from one of the biggest and most important Brazilian newspapers, Folha de São Paulo, to determine what factors are responsible for and improve consumer's forecast accuracy. We found gender, age and city of residence as major elements when analyzing micro-data. Aggregate data shows the past inflation as an important trigger in the formation of consumers' expectations and professional forecasts as negligible. Moreover, the media plays a significant role, accounting not only for the expectations' formation but for a better understanding of actual inflation as well.

  17. Lightweight Inflatable Cryogenic Tank Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal describes the development of an inflatable and lightweight polymer-fabric structured pressure vessel designed for the containment of cryogenic fluids....

  18. Inflatable artificial sphincter - series (image)

    Science.gov (United States)

    ... that surrounds the urethra as it exits the bladder. ... An artificial sphincter consists of three parts: a cuff that fits around the bladder neck a pressure regulating balloon a pump that inflates the cuff. To treat urinary incontinence, the cuff ...

  19. Inflation and unemployment revisited: Grease vs. sand

    OpenAIRE

    Erica L. Groshen; Schweitzer, Mark E

    1998-01-01

    As inflation rates in the United States decline, analysts are asking if there are economic reasons to hold the rates at levels above zero. Previous studies of whether inflation "greases the wheels" of the labor market ignore inflation's potential for disrupting wage patterns in the same market. This paper outlines an institutionally-based model of wage-setting that allows the benefits of inflation (downward wage flexibility) to be separated from disruptive uncertainty about inflation rate (un...

  20. Theoretical aspects of inflation targeting

    Directory of Open Access Journals (Sweden)

    Obradović Jelena

    2014-01-01

    Full Text Available Inflation targeting is one of the possible strategies used by central banks during conducting monetary policy. The basic characteristics, advantages and disadvantages of inflation targeting will be presented in this paper. The focus is on the the presentation and interpretation of the understanding of this strategy from the perspective of monetarist and Keynesian theory, the theory of rational expectations, and methodological analysis of the strategy in light of the game theory using payoff matrix.

  1. Fair Behavior and Inflation Persistence

    OpenAIRE

    Seidel, Gerald

    2005-01-01

    In their seminal paper Fuhrer and Moore (1995) provide an explanation for the existence of inflation inertia. Driscoll and Holden (2003) argue that under more plausible assumptions the model of Fuhrer and Moore (1995) will coincide with the model of Taylor (1979) which can only explain sticky prices but not sticky inflation. Following the suggestions by Driscoll and Holden (2003) we extend their setting allowing for other-regarding preferences. It turns out that this new extended model is con...

  2. Inflation Persistence and Relative Contracting

    OpenAIRE

    John C. Driscoll; Steinar Holden

    2003-01-01

    Macroeconomists have for some time been aware that the New Keynesian Phillips curve, though highly popular in the literature, cannot explain the persistence observed in actual inflation. We argue that one of the more prominent alternative formulations, the Fuhrer and Moore (1995) relative contracting model, is highly problematic. Fuhrer and Moore's 1995 formulation generates inflation persistence, but this is a consequence of their assuming that workers care about the past real wages of other...

  3. The Euro and world inflation

    OpenAIRE

    George Selgin; David VanHoose

    2007-01-01

    This paper uses a three-region framework to examine the effects of European currency unification on EMU and US inflation rates. It considers ways in which increased participation in the EMU might influence inflation choices in Europe and the United States. It also considers how alternative monetary policies and parameter values might influence the extent of participation in the EMU. Copyright 2007 , Oxford University Press.

  4. Accidental inflation from Kaehler uplifting

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Dayan, Ido; Westphal, Alexander; Wieck, Clemens [Deutsches Elektronen-Synchrotron DESY, Hamburg (Germany). Theory Group; Jing, Shenglin [Toronto Univ., ON (Canada). Canadian Inst. for Theoretical Astrophysics; Toronto Univ., ON (Canada). Dept. of Astronomy and Astrophysics

    2013-09-15

    We analyze the possibility of realizing inflation with a subsequent dS vacuum in the Kaehler uplifting scenario. The inclusion of several quantum corrections to the 4d effective action evades previous no-go theorems and allows for construction of simple and successful models of string inflation. The predictions of several benchmark models are in accord with current observations, i.e., a red spectral index, negligible non-gaussianity, and spectral distortions similar to the simplest models of inflation. A particularly interesting subclass of models are ''left-rolling'' ones, where the overall volume of the compactified dimensions shrinks during inflation. We call this phenomenon ''inflation by deflation'' (IBD), where deflation refers to the internal manifold. This subclass has the appealing features of being insensitive to initial conditions, avoiding the overshooting problem, and allowing for observable running {alpha}<{proportional_to}0.012 and enhanced tensor-to-scalar ratio r{proportional_to}10{sup -5}. The latter results differ significantly from many string inflation models.

  5. Axion landscape and natural inflation

    Energy Technology Data Exchange (ETDEWEB)

    Higaki, Tetsutaro, E-mail: thigaki@post.kek.jp [Theory Center, KEK, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Takahashi, Fuminobu, E-mail: fumi@tuhep.phys.tohoku.ac.jp [Department of Physics, Tohoku University, Sendai 980-8578 (Japan); Kavli Institute for the Physics and Mathematics of the Universe (WPI), Todai Institutes for Advanced Study, University of Tokyo, Kashiwa 277-8583 (Japan)

    2015-05-11

    Multiple axions form a landscape in the presence of various shift symmetry breaking terms. Eternal inflation populates the axion landscape, continuously creating new universes by bubble nucleation. Slow-roll inflation takes place after the tunneling event, if a very flat direction with a super-Planckian decay constant arises due to the alignment mechanism. We study the vacuum structure as well as possible inflationary dynamics in the axion landscape scenario, and find that the inflaton dynamics is given by either natural or multi-natural inflation. In the limit of large decay constant, it is approximated by the quadratic chaotic inflation, which however is disfavored if there is a pressure toward shorter duration of inflation. Therefore, if the spectral index and the tensor-to-scalar ratio turn out to be different from the quadratic chaotic inflation, there might be observable traces of the bubble nucleation. Also, the existence of small modulations to the inflaton potential is a common feature in the axion landscape, which generates a sizable and almost constant running of the scalar spectral index over CMB scales. Non-Gaussianity of equilateral type can also be generated if some of the axions are coupled to massless gauge fields.

  6. Inflation in Flatland

    Science.gov (United States)

    Hinterbichler, Kurt; Joyce, Austin; Khoury, Justin

    2017-01-01

    We investigate the symmetry structure of inflation in 2+1 dimensions. In particular, we show that the asymptotic symmetries of three-dimensional de Sitter space are in one-to-one correspondence with cosmological adiabatic modes for the curvature perturbation. In 2+1 dimensions, the asymptotic symmetry algebra is infinite-dimensional, given by two copies of the Virasoro algebra, and can be traced to the conformal symmetries of the two-dimensional spatial slices of de Sitter. We study the consequences of this infinite-dimensional symmetry for inflationary correlation functions, finding new soft theorems that hold only in 2+1 dimensions. Expanding the correlation functions as a power series in the soft momentum q, these relations constrain the traceless part of the tensorial coefficient at each order in q in terms of a lower-point function. As a check, we verify that the Script O(q2) identity is satisfied by inflationary correlation functions in the limit of small sound speed.

  7. Core inflation indicators for Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Alkhareif Ryadh M.

    2015-01-01

    Full Text Available This paper constructs and analyzes core inflation indicators for Saudi Arabia for the period of March 2012 to May 2014 using two alternative approaches: the exclusion method (ex food and housing/rent and the statistical method. The findings of the analysis suggest that the ex food and housing/ rent inflation is more volatile than the overall CPI inflation over the sample period. In contrast, the statistical core inflation is relatively more stable and less volatile. Moreover, the ex food and housing/rent inflation is only weakly correlated with headline inflation, whereas the statistical core inflation exhibits a stronger correlation. This combination of lower volatility and higher correlation with headline inflation makes the statistical method a much better choice for policymakers. From a monetary policy standpoint, using a bundle of core inflation measures, including both properly constructed exclusion and statistical methods, is more desirable, especially when variation across measures is widespread, as is the case in Saudi Arabia.

  8. Thermalized axion inflation

    Science.gov (United States)

    Ferreira, Ricardo Z.; Notari, Alessio

    2017-09-01

    We analyze the dynamics of inflationary models with a coupling of the inflaton phi to gauge fields of the form phi F tilde F/f, as in the case of axions. It is known that this leads to an instability, with exponential amplification of gauge fields, controlled by the parameter ξ= dot phi/(2fH), which can strongly affect the generation of cosmological perturbations and even the background. We show that scattering rates involving gauge fields can become larger than the expansion rate H, due to the very large occupation numbers, and create a thermal bath of particles of temperature T during inflation. In the thermal regime, energy is transferred to smaller scales, radically modifying the predictions of this scenario. We thus argue that previous constraints on ξ are alleviated. If the gauge fields have Standard Model interactions, which naturally provides reheating, they thermalize already at ξgtrsim2.9, before perturbativity constraints and also before backreaction takes place. In absence of SM interactions (i.e. for a dark photon), we find that gauge fields and inflaton perturbations thermalize if ξgtrsim3.4 however, observations require ξgtrsim6, which is above the perturbativity and backreaction bounds and so a dedicated study is required. After thermalization, though, the system should evolve non-trivially due to the competition between the instability and the gauge field thermal mass. If the thermal mass and the instabilities equilibrate, we expect an equilibrium temperature of Teq simeq ξ H/bar g where bar g is the effective gauge coupling. Finally, we estimate the spectrum of perturbations if phi is thermal and find that the tensor to scalar ratio is suppressed by H/(2T), if tensors do not thermalize.

  9. Accounting for inflation: arguments of recognition in Islamic accounting standards

    OpenAIRE

    Bello Ahmad

    2017-01-01

    The current Islamic Accounting Standards gives little prominence to changes in prices, instead of developing a full blunt standard to address the menace of changes in prices fair value accounting was used. Changes in prices otherwise referred to Inflation may affect and substantially injures sustainability of Islamic financial institutions. An economy that is characterized also as Inflationary may have its financial statements produced under AAOIFI derailing in quality. From transactionary an...

  10. Inflation in a closed universe

    Science.gov (United States)

    Ratra, Bharat

    2017-11-01

    To derive a power spectrum for energy density inhomogeneities in a closed universe, we study a spatially-closed inflation-modified hot big bang model whose evolutionary history is divided into three epochs: an early slowly-rolling scalar field inflation epoch and the usual radiation and nonrelativistic matter epochs. (For our purposes it is not necessary to consider a final dark energy dominated epoch.) We derive general solutions of the relativistic linear perturbation equations in each epoch. The constants of integration in the inflation epoch solutions are determined from de Sitter invariant quantum-mechanical initial conditions in the Lorentzian section of the inflating closed de Sitter space derived from Hawking's prescription that the quantum state of the universe only include field configurations that are regular on the Euclidean (de Sitter) sphere section. The constants of integration in the radiation and matter epoch solutions are determined from joining conditions derived by requiring that the linear perturbation equations remain nonsingular at the transitions between epochs. The matter epoch power spectrum of gauge-invariant energy density inhomogeneities is not a power law, and depends on spatial wave number in the way expected for a generalization to the closed model of the standard flat-space scale-invariant power spectrum. The power spectrum we derive appears to differ from a number of other closed inflation model power spectra derived assuming different (presumably non de Sitter invariant) initial conditions.

  11. Inflation from Asymptotically Safe Theories

    DEFF Research Database (Denmark)

    Nielsen, Niklas Grønlund; Sannino, Francesco; Svendsen, Ole

    2015-01-01

    We investigate models in which inflation is driven by an ultraviolet safe and interacting scalar sector stemming from a new class of nonsupersymmetric gauge field theories. These new theories, differently from generic scalar models, are well defined to arbitrary short distances because of the exi......We investigate models in which inflation is driven by an ultraviolet safe and interacting scalar sector stemming from a new class of nonsupersymmetric gauge field theories. These new theories, differently from generic scalar models, are well defined to arbitrary short distances because...... for inflation. In the minimal coupling case the theory requires large non-perturbative quantum corrections to the quantum potential for the theory to agree with data, while in the non- minimal coupling case the perturbative regime in the couplings of the theory is preferred. Requiring the theory to reproduce...

  12. London equation for monodromy inflation

    Science.gov (United States)

    Kaloper, Nemanja; Lawrence, Albion

    2017-03-01

    We focus on the massive gauge theory formulation of axion monodromy inflation. We argue that a gauge symmetry hidden in these models is the key mechanism protecting inflation from dangerous field theory and quantum gravity corrections. The effective theory of large-field inflation is dual to a massive U (1 ) 4-form gauge theory, which is similar to a massive gauge theory description of superconductivity. The gauge theory explicitly realizes the old Julia-Toulouse proposal for a low-energy description of a gauge theory in a defect condensate. While we work mostly with the example of quadratic axion potential induced by flux monodromy, we discuss how other types of potentials can arise from the inclusion of gauge-invariant corrections to the theory.

  13. INFLATION TARGETING IN EASTERN EUROPE

    Directory of Open Access Journals (Sweden)

    Laurian Lungu

    2006-05-01

    Full Text Available This paper addresses the inflation targeting approach in three transition economies, namely Hungary, Poland and the Czech Republic with the use of Taylor rules as benchmarks. The three economies considered have been successful at achieving disinflation, but deviations of inflation from its target have been persistent in all cases. Except for the Czech Republic, deviations from the Taylor rule are large and persistent, with Hungary displaying the largest fluctuations. Polish interest rates have consistently exceeded those suggested by the Taylor rule and given the prevalence of high unemployment, these undershootings do not augur well for the stability of monetary policy. Finally, the behaviour of Czech interest rates can be remarkably captured by the simple Taylor rule proposed in this paper, suggesting that the Czech National Bank has been the most successful at stabilising inflation and output around their target levels.

  14. Supernatural A-Term Inflation

    Science.gov (United States)

    Lin, Chia-Min; Cheung, Kingman

    Following Ref. 10, we explore the parameter space of the case when the supersymmetry (SUSY) breaking scale is lower, for example, in gauge mediated SUSY breaking model. During inflation, the form of the potential is V0 plus MSSM (or A-term) inflation. We show that the model works for a wide range of the potential V0 with the soft SUSY breaking mass m O(1) TeV. The implication to MSSM (or A-term) inflation is that the flat directions which is lifted by the non-renormalizable terms described by the superpotential W=λ p φ p-1/Mp-3 P with p = 4 and p = 5 are also suitable to be an inflaton field for λp = O(1) provided there is an additional false vacuum term V0 with appropriate magnitude. The flat directions correspond to p = 6 also works for 0 < ˜ V0/M_ P4 < ˜ 10-40.

  15. Dynamics of gauge field inflation

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, Stephon; Jyoti, Dhrubo [Center for Cosmic Origins and Department of Physics and Astronomy, 6127 Wilder Laboratory, Dartmouth College, Hanover, NH 03755 (United States); Kosowsky, Arthur [Department of Physics and Astronomy, University of Pittsburgh, 3941 O' Hara Street, Pittsburgh, PA 15260 (United States); Marcianò, Antonino, E-mail: stephon.alexander@dartmouth.edu, E-mail: dhrubo.jyoti@dartmouth.edu, E-mail: kosowsky@pitt.edu, E-mail: marciano@fudan.edu.cn [Center for Field Theory and Particle Physics and Department of Physics, Fudan University, 220 Handan Road, Shanghai (China)

    2015-05-01

    We analyze the existence and stability of dynamical attractor solutions for cosmological inflation driven by the coupling between fermions and a gauge field. Assuming a spatially homogeneous and isotropic gauge field and fermion current, the interacting fermion equation of motion reduces to that of a free fermion up to a phase shift. Consistency of the model is ensured via the Stückelberg mechanism. We prove the existence of exactly one stable solution, and demonstrate the stability numerically. Inflation arises without fine tuning, and does not require postulating any effective potential or non-standard coupling.

  16. Dynamics of gauge field inflation

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, Stephon; Jyoti, Dhrubo [Center for Cosmic Origins and Department of Physics and Astronomy, 6127 Wilder Laboratory, Dartmouth College, Hanover, NH 03755 (United States); Kosowsky, Arthur [Department of Physics and Astronomy, University of Pittsburgh, 3941 O’Hara Street, Pittsburgh, PA 15260 (United States); Pittsburgh Particle Physics, Astrophysics, and Cosmology Center (Pitt-PACC), 420 Allen Hall, 3941 O’Hara Street, Pittsburgh, PA 15260 (United States); Marcianò, Antonino [Center for Field Theory and Particle Physics & Department of Physics, Fudan University, 220 Handan Road, Shanghai (China)

    2015-05-05

    We analyze the existence and stability of dynamical attractor solutions for cosmological inflation driven by the coupling between fermions and a gauge field. Assuming a spatially homogeneous and isotropic gauge field and fermion current, the interacting fermion equation of motion reduces to that of a free fermion up to a phase shift. Consistency of the model is ensured via the Stückelberg mechanism. We prove the existence of exactly one stable solution, and demonstrate the stability numerically. Inflation arises without fine tuning, and does not require postulating any effective potential or non-standard coupling.

  17. Inflation with light Weyl ghost

    Directory of Open Access Journals (Sweden)

    Tokareva Anna

    2016-01-01

    Full Text Available Inflationary perturbations are considered in a renormalizable but non-unitary theory of gravity with the additional Weyl term. We obtained that ghost degrees of freedom do not spoil the inflation and the scalar perturbation amplitude at the linear level even in a case of the ghost with mass smaller than Hubble parameter at inflation. The ghost impact to the observables is also estimated to be negligible for the range of masses allowed by the experiment. The non-linear level of the theory and its possible application are also discussed.

  18. Large inflated-antenna system

    Science.gov (United States)

    Hinson, W. F.; Keafer, L. S.

    1984-01-01

    It is proposed that for inflatable antenna systems, technology feasibility can be demonstrated and parametric design and scalability (scale factor 10 to 20) can be validated with an experiment using a 16-m-diameter antenna attached to the Shuttle. The antenna configuration consists of a thin film cone and paraboloid held to proper shape by internal pressure and a self-rigidizing torus. The cone and paraboloid would be made using pie-shaped gores with the paraboloid being coated with aluminum to provide reflectivity. The torus would be constructed using an aluminum polyester composite that when inflated would erect to a smooth shell that can withstand loads without internal pressure.

  19. 76 FR 56294 - Inflatable Personal Flotation Devices

    Science.gov (United States)

    2011-09-13

    ... using existing inflatable PFDs, and would enable the marketing of existing inflatable PFDs to youth. The... be done to evaluate sizing requirements for infant or child PFDs. Because the Coast Guard considers...

  20. Inflation perceptions and inflation expectation in South Africa: trends ...

    African Journals Online (AJOL)

    Cape provinces were grouped together, as well as those from Mpumalanga and. Limpopo, as the original 2006 survey data were grouped in this way. The Western. Cape was set as the benchmark category. For the inflation perceptions surveys, the provinces were not grouped together but coded 1 to 8, and the benchmark.

  1. Non-Abelian S-term dark energy and inflation

    Science.gov (United States)

    Rodríguez, Yeinzon; Navarro, Andrés A.

    2018-03-01

    We study the role that a cosmic triad in the generalized SU(2) Proca theory, specifically in one of the pieces of the Lagrangian that involves the symmetric version Sμν of the gauge field strength tensor Fμν, has on dark energy and primordial inflation. Regarding dark energy, the triad behaves asymptotically as a couple of radiation perfect fluids whose energy densities are negative for the S term but positive for the Yang-Mills term. This leads to an interesting dynamical fine-tuning mechanism that gives rise to a combined equation of state parameter ω ≃ - 1 and, therefore, to an eternal period of accelerated isotropic expansion for an ample spectrum of initial conditions. Regarding primordial inflation, one of the critical points of the associated dynamical system can describe a prolonged period of isotropic slow-roll inflation sustained by the S term. This period ends up when the Yang-Mills term dominates the energy density leading to the radiation dominated epoch. Unfortunately, in contrast to the dark energy case, the primordial inflation scenario is strongly sensitive to the coupling constants and initial conditions. The whole model, including the other pieces of the Lagrangian that involve Sμν, might evade the recent strong constraints coming from the gravitational wave signal GW170817 and its electromagnetic counterpart GRB 170817A.

  2. Grade Inflation from a Career Counselor's Perspective.

    Science.gov (United States)

    Kwon, Ik-Whan G.; Kendig, Nancy L.; Bae, Mueun

    1997-01-01

    Explores possible reasons for grade inflation by examining two sets of business graduates (N=300) from McKendree College. Results indicate that grade inflation apparently continued throughout the 1980s and early 1990s. However, if other statistically significant variables, such as age and ACT scores, were considered, then grade inflation seemed…

  3. Inflation Targeting and Business Cycle Synchronization

    OpenAIRE

    Flood, Robert P; Rose, Andrew K

    2009-01-01

    Inflation targeting seems to have a small but positive effect on the synchronization of business cycles; countries that target inflation seem to have cycles that move slightly more closely with foreign cycles. Thus the advent of inflation targeting does not explain the decoupling of global business cycles, for two reasons. Indeed business cycles have not in fact become less synchronized across countries.

  4. 12 CFR 1780.80 - Inflation adjustments.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Inflation adjustments. 1780.80 Section 1780.80... DEVELOPMENT RULES OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Civil Money Penalty Inflation Adjustments § 1780.80 Inflation adjustments. The maximum amount of each civil money penalty within OFHEO's...

  5. No-scale SUGRA SO (10) Inflation

    Indian Academy of Sciences (India)

    2017-10-09

    Oct 9, 2017 ... We show that a renormalizable theory based on gauge group S O ( 10 ) and Higgs system 10 ⊕ 210 ⊕ 126 ⊕ 126 ¯ with no scale supergravity can lead to a Starobinsky kind of potential for inflation. Successful inflation is possible in cases where the potential during inflation corresponds to S U ( 3 ) C × S U ...

  6. Does Education Corrupt? Theories of Grade Inflation

    Science.gov (United States)

    Oleinik, Anton

    2009-01-01

    Several theories of grade inflation are discussed in this review article. It is argued that grade inflation results from the substitution of criteria specific to the search for truth by criteria of quality control generated outside of academia. Particular mechanisms of the grade inflation that occurs when a university is transformed into a…

  7. Inflation,Inflation Variability, and Output Performance. Venezuela 1951-2002

    OpenAIRE

    Olivo, Victor

    2014-01-01

    This paper explores the relationship between the level of inflation, inflation variability, and output performance in the Venezuelan economy for the period 1951-2002. The paper examines the mechanism through which higher inflation translates into lower non-oil real GDP growth. We find empirical evidence that supports Friedman's (1977) contention that higher inflation produces more inflation volatility /uncertainty that leads to relative price variability that in turn, is harmful for the prope...

  8. Non-metric chaotic inflation

    Energy Technology Data Exchange (ETDEWEB)

    Enqvist, Kari [Physics Department, University of Helsinki, and Helsinki Institute of Physics, FIN-00014 Helsinki (Finland); Koivisto, Tomi [Institute for Theoretical Physics and Spinoza Institute, Leuvenlaan 4, 3584 CE Utrecht (Netherlands); Rigopoulos, Gerasimos, E-mail: kari.enqvist@helsinki.fi, E-mail: T.S.Koivisto@astro.uio.no, E-mail: rigopoulos@physik.rwth-aachen.de [Institut für Theoretische Teilchenphysik und Kosmologie, RWTH Aachen University, D-52056 Aachen (Germany)

    2012-05-01

    We consider inflation within the context of what is arguably the simplest non-metric extension of Einstein gravity. There non-metricity is described by a single graviscalar field with a non-minimal kinetic coupling to the inflaton field Ψ, parameterized by a single parameter γ. There is a simple equivalent description in terms of a massless field and an inflaton with a modified potential. We discuss the implications of non-metricity for chaotic inflation and find that it significantly alters the inflaton dynamics for field values Ψ∼>M{sub P}/γ, dramatically changing the qualitative behaviour in this regime. In the equivalent single-field description this is described as a cuspy potential that forms of barrier beyond which the inflation becomes a ghost field. This imposes an upper bound on the possible number of e-folds. For the simplest chaotic inflation models, the spectral index and the tensor-to-scalar ratio receive small corrections dependent on the non-metricity parameter. We also argue that significant post-inflationary non-metricity may be generated.

  9. The Implications of Grade Inflation

    DEFF Research Database (Denmark)

    Smith, David E.; Fleisher, Steven

    2011-01-01

    The authors review current and past practices of the grade inflation controversy and present ways to return to each institution’s established grading guidelines. Students are graded based on knowledge gathered. Certain faculty members use thorough evaluative methods, such as written and oral...

  10. How are inflation targets set?

    Czech Academy of Sciences Publication Activity Database

    Horváth, R.; Matějů, Jakub

    -, č. 426 (2010), s. 1-35 ISSN 1211-3298 Grant - others:MŠk(CZ) SVV-2010-261801 Institutional research plan: CEZ:MSM0021620846 Keywords : inflation targeting * central bank * credibility Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp426.pdf

  11. Davis Meeting on Cosmic Inflation

    CERN Document Server

    Kaloper, N; Knox, L; Cosmic Inflation

    2003-01-01

    The Davis Meeting on Cosmic Inflation marked an exciting milestone on the road to precision cosmology. This is the index page for the proceedings of the conference. Individual proceedings contributions, when they appear on this archive, are linked from this page.

  12. Wage inflation and worker uncertainty

    OpenAIRE

    Mark E. Schweitzer

    1997-01-01

    Compares two possible explanations of why pay increases continue to be moderate in a vigorous labor market--workers' uncertainty about their jobs and human resource managers' wage-setting behavior--and looks at how each explanation matches the evidence on the timing of inflation and wage changes.

  13. Eternal inflation with Liouville cosmology

    National Research Council Canada - National Science Library

    Nakayama, Yu

    2011-01-01

    ... cosmology, in particular eternal inflation, the effects of the quantum gravity might be important. These effects on the vacuum decay of the universe has been largely unknown partly due to the lack of well-defined off-shell formulation of the quantum gravity. At the level of the semiclassical Einstein gravity, the Coleman–De Luccia (CDL) in...

  14. Inflation as de Sitter instability

    Energy Technology Data Exchange (ETDEWEB)

    Cadoni, Mariano; Franzin, Edgardo [Universita di Cagliari, Cittadella Universitaria, Dipartimento di Fisica, Monserrato (Italy); INFN, Sezione di Cagliari, Monserrato (Italy); Mignemi, Salvatore [INFN, Sezione di Cagliari, Monserrato (Italy); Universita di Cagliari, Dipartimento di Matematica e Informatica, Cagliari (Italy)

    2016-09-15

    We consider cosmological inflation generated by a scalar field slowly rolling off from a de Sitter maximum of its potential. The models belong to the class of hilltop models and represent the most general model of this kind in which the scalar potential can be written as the sum of two exponentials. The minimally coupled Einstein-scalar gravity theory obtained in this way is the cosmological version of a two-scale generalization of known holographic models, allowing for solitonic solutions interpolating between an AdS spacetime in the infrared and scaling solutions in the ultraviolet. We then investigate cosmological inflation in the slow-roll approximation. Our model reproduces correctly, for a wide range of its parameters, the most recent experimental data for the power spectrum of primordial perturbations. Moreover, it predicts inflation at energy scales of four to five orders of magnitude below the Planck scale. At the onset of inflation, the mass of the tachyonic excitation, i.e. of the inflaton, turns out to be seven to eight orders of magnitude smaller than the Planck mass. (orig.)

  15. Hering-Breuer inflation reflex in young and adult mammals.

    Science.gov (United States)

    Gaultier, C; Mortola, J P

    1981-09-01

    The apnea following lung inflation (Hering-Breuer expiratory promoting reflex) is a vagally mediated reflex which is initiated by the activation of pulmonary stretch receptors (PSR) and terminated by the interaction of several factors, which include adaptation of PSR, chemical stimuli, level of anaesthesia, and body temperature. Since PSR activity is determined by the changes in airway tension, the interpretation of the strength of vagal reflexes on the basis of changes in lung volume rather than transpulmonary pressure can be misleading when the mechanical properties of the respiratory system are not constant. In this study we compared the reflex apnea resulting from lung inflation of young and adult mammals, the respiratory system it can be considered weaker or stronger in the young depending upon the normalizing parameter used. However, when considered on the basis of the relative changes in transpulmonary pressure, which better reflects the activation of PSR, the reflex is weaker in young rats and rabbits than in their adult counterparts an similar in dogs. The analysis of the underlying mechanisms suggests a weaker vagal contribution in the young animal, but a satisfactory conclusion requires a better knowledge of the factors which, in the younger animals, result in the termination of the apnea.

  16. Testing Multi-Field Inflation

    Science.gov (United States)

    Peterson, Courtney Marie

    Cosmic inflation is currently the leading theory for producing the initial density fluctuations that led to the formation of structure in our Universe. This thesis examines multi-field models of inflation and how such models can be constrained using cosmic data. We first explore the power spectra from general two-field inflation. Using a covariant formalism, we derive evolution equations for the unperturbed and perturbed fields. We use these equations to derive semi-analytic formulas for the power spectra. In tandem, we discuss how the features of the inflaton roll path and the geometry of field space translate into distinct features in the spectra. We then apply our formalism to confront four classes of models with WMAP data, showing that the viability of a model depends not only on the inflationary Lagrangian but also on the initial conditions. Ultimately, for a two-field model to be consistent with observations, it must possess the right balance of kinematical and dynamical behaviors, which we reduce to a set of functions that represent the main characteristics of any two-field model of inflation. Next, we tackle non-Gaussianity from general two-field inflation. We derive semi-analytic formulas for the local bispectrum and trispectrum in terms of spectral observables and the transfer functions. We also provide a new consistency relation involving two of the non-Gaussianity parameters. We show that in order to generate observably large non-Gaussianity during inflation, the sourcing of curvature modes by isocurvature modes must be extremely sensitive to a change in the initial conditions orthogonal to the inflaton trajectory. Under some minimal assumptions, this is satisfied only when the inflaton rolls along a ridge in the potential for some time and turns somewhat. Finally, we extend the above results to general multi-field inflation. We examine the series of mode sourcing equations in multi-field models, focusing on the implications for the effective number of

  17. Inflazione mondiale e politica nazionale di stabilità monetaria. (World inflation and domestic monetary stability

    Directory of Open Access Journals (Sweden)

    F.A. LUTZ

    2014-07-01

    Full Text Available Since the end of the Second World War the world economy has, apart from brief interludes of price stability, been in the grip of continuous inflation. No country seems to have managed to escape this world inflation entirely, although a few have made the very greatest efforts to do so. The present article considers why these efforts were in vain and if there really is no defence against “imported” world inflation. The author analyses the four types of policy for avoiding inflation - restrictive monetary and fiscal policy, export of capital, periodic changes in exchange parities and flexible exchange rates. The analysis suggests that the first two are least recommendable in the face of chronic balance of payments surpluses because they do not eradicate the surplus itself and can be sustained for only a relatively short period of time. The latter two do eliminate the external surplus, however, in the face of continuous world inflation, periodic  revaluation does so only temporarily while flexible rates represent a permanent solution. The author concludes that world inflation can be checked only if there is an international monetary order which keeps reserves so scarce that no country feels able to allow inflation to proceed.JEL: E31, E42, E52, E62

  18. Targeting nominal income growth or inflation?

    DEFF Research Database (Denmark)

    Jensen, Henrik

    2002-01-01

    Within a simple New Keynesian model emphasizing forward-looking behavior of private agents, I evaluate optimal nominal income growth targeting versus optimal inflation targeting. When the economy is mainly subject to shocks that do not involve monetary policy trade-offs for society, inflation...... targeting is preferable. Otherwise, nominal income growth targeting may be superior because it induces inertial policy making, which improves the inflation-output-gap trade-off. Somewhat paradoxically, inflation targeting may be relatively less favorable the more society dislikes inflation, and the more...

  19. Inflation, Reionization, and All That: The Primordial Inflation Explorer

    Science.gov (United States)

    Kogut, Alan J.

    2012-01-01

    The Primordial Inflation Explorer is an Explorer-class mission to measure the gravity-wave signature of primordial inflation through its distinctive imprint on the linear polarization of the cosmic microwave background. PIXIE uses an innovative optical design to achieve background-limited sensitivity in 400 spectral channels spanning 2.5 decades in frequency from 30 GHz to 6 THz (1 cm to 50 micron wavelength). The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r < 10(exp -3) at 5 standard deviations. The rich PIXIE data set will also constrain physical processes ranging from Big Bang cosmology to the nature of the first stars to physical conditions within the interstellar medium of the Galaxy. I describe the PIXIE instrument and mission architecture needed to detect the inflationary signature using only 4 semiconductor bolometers.

  20. Accounting for inflation: arguments of recognition in Islamic accounting standards

    Directory of Open Access Journals (Sweden)

    Bello Ahmad

    2017-01-01

    Full Text Available The current Islamic Accounting Standards gives little prominence to changes in prices, instead of developing a full blunt standard to address the menace of changes in prices fair value accounting was used. Changes in prices otherwise referred to Inflation may affect and substantially injures sustainability of Islamic financial institutions. An economy that is characterized also as Inflationary may have its financial statements produced under AAOIFI derailing in quality. From transactionary angle, creditors are going to be shortchanged and Debtors benefits; debtor- creditor Hypotheses. In this paper effort was made to explore the fundamental reasons for non- recognition of inflation in Islamic Accounting Standards and fundamental Islamic framework that may permit that.

  1. Inflation from nilpotent Kaehler corrections

    Energy Technology Data Exchange (ETDEWEB)

    McDonough, Evan [McGill Univ. Montreal, QC (Canada); Scalisi, Marco [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2016-09-15

    We develop a new class of supergravity cosmological models where inflation is induced by terms in the Kaehler potential which mix a nilpotent superfield S with a chiral sector Φ. As the new terms are non-(anti)holomorphic, and hence cannot be removed by a Kaehler transformation, these models are intrinsically Kaehler potential driven. Such terms could arise for example due to a backreaction of an anti-D3 brane on the string theory bulk geometry. We show that this mechanism is very general and allows for a unified description of inflation and dark energy, with controllable SUSY breaking at the vacuum. When the internal geometry of the bulk field is hyperbolic, we prove that small perturbative Kaehler corrections naturally lead to α-attractor behaviour, with inflationary predictions in excellent agreement with the latest Planck data.

  2. Higgsed Chromo-Natural Inflation

    Energy Technology Data Exchange (ETDEWEB)

    Adshead, Peter [Department of Physics, University of Illinois at Urbana-Champaign,1110 West Green Street, Urbana, IL 61801 (United States); Martinec, Emil [Enrico Fermi Institute, University of Chicago,5640 S. Ellis Ave., Chicago, IL 60637-1433 (United States); Department of Physics, University of Chicago,5640 S. Ellis Ave., Chicago, IL 60637-1433 (United States); Sfakianakis, Evangelos I. [Department of Physics, University of Illinois at Urbana-Champaign,1110 West Green Street, Urbana, IL 61801 (United States); Wyman, Mark [PDT Partners,1745 Broadway, 25th Floor, New York, NY 10019 (United States)

    2016-12-27

    We demonstrate that Chromo-Natural Inflation can be made consistent with observational data if the SU(2) gauge symmetry is spontaneously broken. Working in the Stueckelberg limit, we show that isocurvature is negligible, and the resulting adiabatic fluctuations can match current observational constraints. Observable levels of chirally-polarized gravitational radiation (r∼10{sup −3}) can be produced while the evolution of all background fields is sub-Planckian. The gravitational wave spectrum is amplified via linear mixing with the gauge field fluctuations, and its amplitude is not simply set by the Hubble rate during inflation. This allows observable gravitational waves to be produced for an inflationary energy scale below the GUT scale. The tilt of the resulting gravitational wave spectrum can be either blue or red.

  3. Natural inflation from polymer quantization

    Science.gov (United States)

    Ali, Masooma; Seahra, Sanjeev S.

    2017-11-01

    We study the polymer quantization of a homogeneous massive scalar field in the early Universe using a prescription inequivalent to those previously appearing in the literature. Specifically, we assume a Hilbert space for which the scalar field momentum is well defined but its amplitude is not. This is closer in spirit to the quantization scheme of loop quantum gravity, in which no unique configuration operator exists. We show that in the semiclassical approximation, the main effect of this polymer quantization scheme is to compactify the phase space of chaotic inflation in the field amplitude direction. This gives rise to an effective scalar potential closely resembling that of hybrid natural inflation. Unlike polymer schemes in which the scalar field amplitude is well defined, the semiclassical dynamics involves a past cosmological singularity; i.e., this approach does not mitigate the big bang.

  4. Resonant magnetic fields from inflation

    CERN Document Server

    Byrnes, Christian T; Jain, Rajeev Kumar; Urban, Federico R

    2012-01-01

    We propose a novel scenario to generate primordial magnetic fields during inflation induced by an oscillating coupling of the electromagnetic field to the inflaton. This resonant mechanism has two key advantages over previous proposals. First of all, it generates a narrow band of magnetic fields at any required wavelength, thereby allaying the usual problem of a strongly blue spectrum and its associated backreaction. Secondly, it avoids the need for a strong coupling as the coupling is oscillating rather than growing or decaying exponentially. Despite these major advantages, we find that the backreaction is still far too large during inflation if the generated magnetic fields are required to have a strength of ${\\cal O}(10^{-15}\\, \\Gauss)$ today on observationally interesting scales. We provide a more general no-go argument, proving that this problem will apply to any model in which the magnetic fields are generated on subhorizon scales and freeze after horizon crossing.

  5. Cybersecurity Risks: Are They Inflated?

    Directory of Open Access Journals (Sweden)

    Petr Chrapavy

    2016-05-01

    Full Text Available With various views being posed on cybersecurity, this paper examines the proposition that cybersecurity risks are inflated. Due to the complexity of the cybersecurity environment, the risks will be dichotomised into two distinct categories—those posed by cybercrime, and those classified as cyber-warfare. In relation to cyber-crime, the paper examines the rise of cyber-crime, its costs, and the views of these factors by “alarmists” and “sceptics.” In relation to cyber-war, the paper sets aside the emotive issue of the consequences and focuses on the likelihood of a catastrophic attack. The paper concludes that the risk of cyber-crime is real, but the sometimes mooted existential threat poses by cyber-war is inflated. The paper argues that it is important for cyber defences to improve in line with the risks, and to do this, researchers need to work across both categories of cybersecurity.

  6. Macroeconomic variables and food price inflation, nonfood price inflation and overall inflation: A case of an emerging market

    Directory of Open Access Journals (Sweden)

    Raphael T Mpofu

    2017-03-01

    Full Text Available The paper analyses the association between certain macroeconomic variables and food price inflation, non-food price inflation and overall inflation in Zimbabwe, and also seeks to determine the level of association between these variables, given food security implications and overall well-being of its citizens. The study reveals that during the 2010 to 2016 period, Zimbabwe experienced stable food prices—annual food price inflation for food and non-alcoholic beverages averaged a relatively low growth rate of 0.12% monthly, while non-food inflation monthly growth rate was 0.09% and overall inflation growth rate was 0.11%. Although inflation from 2010 had been declining, of late, the increase in annual inflation has been underpinned by a rise in non-food inflation. Zimbabwe’s annual inflation remains lower than inflation rates in other countries in the region. Despite the increases lately in overall inflation, it remained below zero in January 2016, mostly driven by the depreciation of the South African rand and declining international oil prices. It should also be noted that domestic demand continued to decline in 2015, leading to the observed decline in both food and non-food prices. While food inflation has remained relatively low, it should be noted that non-food expenditures is significant component of the household budget and the rising prices result often lead to declining purchasing power and force households to make difficult choices in terms of their purchases. The findings of the study are food inflation has a low association with the independent variables under study; Zimbabwe broad money supply, rand-dollar exchange rates and the South Africa food inflation. There is, however, a very strong association between non-food inflation and these independent variables, as well as between overall inflation and the independent variables. Given the mostly rural population and the high level of unemployment in Zimbabwe, it can be surmised that

  7. Frame covariant nonminimal multifield inflation

    Science.gov (United States)

    Karamitsos, Sotirios; Pilaftsis, Apostolos

    2018-02-01

    We introduce a frame-covariant formalism for inflation of scalar-curvature theories by adopting a differential geometric approach which treats the scalar fields as coordinates living on a field-space manifold. This ensures that our description of inflation is both conformally and reparameterization covariant. Our formulation gives rise to extensions of the usual Hubble and potential slow-roll parameters to generalized fully frame-covariant forms, which allow us to provide manifestly frame-invariant predictions for cosmological observables, such as the tensor-to-scalar ratio r, the spectral indices nR and nT, their runnings αR and αT, the non-Gaussianity parameter fNL, and the isocurvature fraction βiso. We examine the role of the field space curvature in the generation and transfer of isocurvature modes, and we investigate the effect of boundary conditions for the scalar fields at the end of inflation on the observable inflationary quantities. We explore the stability of the trajectories with respect to the boundary conditions by using a suitable sensitivity parameter. To illustrate our approach, we first analyze a simple minimal two-field scenario before studying a more realistic nonminimal model inspired by Higgs inflation. We find that isocurvature effects are greatly enhanced in the latter scenario and must be taken into account for certain values in the parameter space such that the model is properly normalized to the observed scalar power spectrum PR. Finally, we outline how our frame-covariant approach may be extended beyond the tree-level approximation through the Vilkovisky-De Witt formalism, which we generalize to take into account conformal transformations, thereby leading to a fully frame-invariant effective action at the one-loop level.

  8. General sGoldstino Inflation

    CERN Document Server

    Ferrara, Sergio

    2016-10-24

    We prove that all inflationary models, including those with dark energy after the end of inflation, can be embedded in minimal supergravity with a single chiral superfield. Moreover, the amount of supersymmetry breaking is independently tunable due to a degeneracy in the choice for the superpotential. The inflaton is a scalar partner of the Goldstino in this set-up. We illustrate our general procedure with two examples that are favoured by the Planck data.

  9. Sneutrino chaotic inflation and landscape

    Directory of Open Access Journals (Sweden)

    Hitoshi Murayama

    2014-11-01

    Full Text Available The most naive interpretation of the BICEP2 data is the chaotic inflation by an inflaton with a quadratic potential. When combined with supersymmetry, we argue that the inflaton plays the role of right-handed scalar neutrino based on rather general considerations. The framework suggests that the right-handed sneutrino tunneled from a false vacuum in a landscape to our vacuum with a small negative curvature and suppressed scalar perturbations at large scales.

  10. Reheating for closed string inflation

    Energy Technology Data Exchange (ETDEWEB)

    Cicoli, Michele [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Mazumdar, Anupam [Lancaster Univ. (United Kingdom). Physics Dept.; Copenhagen Univ. (Denmark). Niels Bohr Institute

    2010-05-15

    We point out some of the outstanding challenges for embedding inflationary cosmology within string theory studying the process of reheating for models where the inflaton is a closed string mode parameterising the size of an internal cycle of the compactification manifold. A realistic model of inflation must explain the tiny perturbations in the cosmic microwave background radiation and also how to excite the ordinary matter degrees of freedom after inflation, required for the success of Big Bang Nucleosynthesis. We study these issues focusing on two promising inflationary models embedded in LARGE volume type IIB flux compactifications. We show that phenomenological requirements and consistency of the effective field theory treatment imply the presence at low energies of a hidden sector together with a visible sector, where the Minimal Supersymmetric Standard Model fields are residing. A detailed calculation of the inflaton coupling to the fields of the hidden sector, visible sector, and moduli sector, reveals that the inflaton fails to excite primarily the visible sector fields, instead hidden sector fields are excited copiously after the end of inflation. This sets severe constraints on hidden sector model building where the most promising scenario emerges as a pure N=1 SYM theory, forbidding the kinematical decay of the inflaton to the hidden sector. In this case it is possible to reheat the Universe with the visible degrees of freedom even though in some cases we discover a new tension between TeV scale SUSY and reheating on top of the well-known tension between TeV scale SUSY and inflation. (orig.)

  11. Frame covariant nonminimal multifield inflation

    Directory of Open Access Journals (Sweden)

    Sotirios Karamitsos

    2018-02-01

    Full Text Available We introduce a frame-covariant formalism for inflation of scalar-curvature theories by adopting a differential geometric approach which treats the scalar fields as coordinates living on a field-space manifold. This ensures that our description of inflation is both conformally and reparameterization covariant. Our formulation gives rise to extensions of the usual Hubble and potential slow-roll parameters to generalized fully frame-covariant forms, which allow us to provide manifestly frame-invariant predictions for cosmological observables, such as the tensor-to-scalar ratio r, the spectral indices nR and nT, their runnings αR and αT, the non-Gaussianity parameter fNL, and the isocurvature fraction βiso. We examine the role of the field space curvature in the generation and transfer of isocurvature modes, and we investigate the effect of boundary conditions for the scalar fields at the end of inflation on the observable inflationary quantities. We explore the stability of the trajectories with respect to the boundary conditions by using a suitable sensitivity parameter. To illustrate our approach, we first analyze a simple minimal two-field scenario before studying a more realistic nonminimal model inspired by Higgs inflation. We find that isocurvature effects are greatly enhanced in the latter scenario and must be taken into account for certain values in the parameter space such that the model is properly normalized to the observed scalar power spectrum PR. Finally, we outline how our frame-covariant approach may be extended beyond the tree-level approximation through the Vilkovisky–De Witt formalism, which we generalize to take into account conformal transformations, thereby leading to a fully frame-invariant effective action at the one-loop level.

  12. The Primordial Inflation Explorer (PIXIE)

    Science.gov (United States)

    Kogut, Alan; Chluba, Jens; Fixsen, Dale J.; Meyer, Stephan; Spergel, David

    2016-01-01

    The Primordial Inflation Explorer is an Explorer-class mission to open new windows on the early universe through measurements of the polarization and absolute frequency spectrum of the cosmic microwave background. PIXIE will measure the gravitational-wave signature of primordial inflation through its distinctive imprint in linear polarization, and characterize the thermal history of the universe through precision measurements of distortions in the blackbody spectrum. PIXIE uses an innovative optical design to achieve background-limited sensitivity in 400 spectral channels spanning over 7 octaves in frequency from 30 GHz to 6 THz (1 cm to 50 micron wavelength). Multi-moded non-imaging optics feed a polarizing Fourier Transform Spectrometer to produce a set of interference fringes, proportional to the difference spectrum between orthogonal linear polarizations from the two input beams. Multiple levels of symmetry and signal modulation combine to reduce systematic errors to negligible levels. PIXIE will map the full sky in Stokes I, Q, and U parameters with angular resolution 2.6 degrees and sensitivity 70 nK per 1degree square pixel. The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r inflation to the nature of the first stars and the physical conditions within the interstellar medium of the Galaxy. We describe the PIXIE instrument and mission architecture required to measure the CMB to the limits imposed by astrophysical foregrounds.

  13. Achieving and maintaining lung volume in the preterm infant: from the first breath to the NICU.

    Science.gov (United States)

    Lista, Gianluca; Maturana, Andrés; Moya, Fernando R

    2017-10-01

    The main goal for the neonatologist is to facilitate the adaptation to extra-uterine life during initial transition, while minimizing lung injury opening and protecting the premature lung from the first breath onwards. An appropriate management from birth should lead to the achievement of an early functional residual capacity (FRC), and the following steps should aim at maintaining an adequate lung volume. To date, different strategies are available to optimize fetal-neonatal transition and promote lung recruitment. New ventilation approaches, such as sustained lung inflation (SLI) and "open lung strategy", well-established ventilation techniques with a more tailored application and less invasive modalities to administer surfactant have been recently introduced in clinical practice with promising results. given the current status of neonatal care, it seems that lung injury and BPD could be reduced with multiple strategies starting early in the delivery room. Literature underlines the importance of a respiratory tailored management of preterm infants from birth and during the whole NICU stay. What is Known: • Experimental and clinical studies have shown that the transition from fetal to adult type cardiorespiratory circulation needs an adequate lung ventilation. An appropriate management in the delivery room should lead to the achievement of an early FRC, and through the following steps, the neonatologist should aim at maintaining an adequate lung volume. • Literature underlines the importance of a respiratory tailored management of preterm infants during the whole NICU stay to maintain the benefits of a successful postnatal adaption. What is New: • Herewith, we describe the most relevant and recent interventions which can be performed from the delivery room to the NICU stay to guarantee an adequate tradition to postnatal life and an effective cardiorespiratory stability.

  14. Vacuum transitions and eternal inflation

    Science.gov (United States)

    Johnson, Matthew C.

    In this thesis, we focus on aspects of inflation and eternal inflation arising in scalar field theories coupled to gravity which possess a number of metastable states. Such theories contain instantons that interpolate between the metastable potential minima, corresponding to the nucleation of bubbles containing a new phase in a background of the old phase. In the first part of this thesis, we describe the classical dynamics and quantum nucleation of vacuum bubbles. We classify all possible spherically symmetric, thin-wall solutions with arbitrary interior and exterior cosmological constant, and find that bubbles possessing a turning point are unstable to aspherical perturbations. Next, we turn to the quantum nucleation of bubbles with zero mass. Focusing on instantons interpolating between positive and negative energy minima, we find that there exists a "Great Divide" in the space of potentials, across which the lifetime of metastable states differs drastically. Generalizing a semi-classical Hamiltonian formalism to treat the nucleation of bubbles with nonzero mass, we show that a number of tunneling mechanisms can be unified in the thin-wall limit, and directly compare their probabilities. In the second part of this thesis, we discuss the measure problem in eternal inflation. We give a detailed analysis of the prospects for making predictions in eternal inflation, and describe the existing probability measures and the connections between them. We then show that all existing measures exhibit a number of rather generic phenomena, for example strongly weighting vacua that can undergo rapid transitions between each other. It is argued that making predictions will require a measure that weights histories as opposed to vacua, and we develop a formalism to addresses this. Finally, we assess the prospects for observing collisions between vacuum bubbles in an eternally inflating universe. Contrary to conventional wisdom, we find that under certain assumptions most

  15. The scale of inflation in the landscape

    Directory of Open Access Journals (Sweden)

    F.G. Pedro

    2014-12-01

    Full Text Available We determine the frequency of regions of small-field inflation in the Wigner landscape as an approximation to random supergravities/type IIB flux compactifications. We show that small-field inflation occurs exponentially more often than large-field inflation. The power of primordial gravitational waves from inflation is generically tied to the scale of inflation. As for small-field models this is below observational reach, their exponential enhancement seems to indicate a tendency towards small tensor-to-scalar ratio r. However, cosmologically viable inflationary regions must provide for a successful exit from inflation into a meta-stable dS minimum. Hence future work will need to determine the ‘graceful exit likelihood’ before any statement about the statistically expected level of tensor modes r is possible.

  16. The scale of inflation in the landscape

    Energy Technology Data Exchange (ETDEWEB)

    Pedro, F.G.; Westphal, A. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany). Theory Group

    2013-03-15

    We determine the frequency of regions of small-field inflation in the Wigner landscape as an approximation to random supergravities/type IIB flux compactifications. We show that small-field inflation occurs exponentially more often than large-field inflation The power of primordial gravitational waves from inflation is generically tied to the scale of inflation. For small-field models this is below observational reach. However, we find small-field inflation to be dominated by the highest inflationary energy scales compatible with a sub-Planckian field range. Hence, we expect a typical tensor-to-scalar ratio r{proportional_to}O(10{sup -3}) currently undetectable in upcoming CMB measurements.

  17. Inflation of Unreefed and Reefed Extraction Parachutes

    Science.gov (United States)

    Ray, Eric S.; Varela, Jose G.

    2015-01-01

    Data from the Orion and several other test programs have been used to reconstruct inflation parameters for 28 ft Do extraction parachutes as well as the parent aircraft pitch response during extraction. The inflation force generated by extraction parachutes is recorded directly during tow tests but is usually inferred from the payload accelerometer during Low Velocity Airdrop Delivery (LVAD) flight test extractions. Inflation parameters are dependent on the type of parent aircraft, number of canopies, and standard vs. high altitude extraction conditions. For standard altitudes, single canopy inflations are modeled as infinite mass, but the non-symmetric inflations in a cluster are modeled as finite mass. High altitude extractions have necessitated reefing the extraction parachutes, which are best modeled as infinite mass for those conditions. Distributions of aircraft pitch profiles and inflation parameters have been generated for use in Monte Carlo simulations of payload extractions.

  18. Cointegration Approach to Analysing Inflation in Croatia

    Directory of Open Access Journals (Sweden)

    Lena Malešević-Perović

    2009-06-01

    Full Text Available The aim of this paper is to analyse the determinants of inflation in Croatia in the period 1994:6-2006:6. We use a cointegration approach and find that increases in wages positively influence inflation in the long-run. Furthermore, in the period from June 1994 onward, the depreciation of the currency also contributed to inflation. Money does not explain Croatian inflation. This irrelevance of the money supply is consistent with its endogeneity to exchange rate targeting, whereby the money supply is determined by developments in the foreign exchange market. The value of inflation in the previous period is also found to be significant, thus indicating some inflation inertia.

  19. A comparison of inflation expectations and inflation credibility in South Africa: results from survey data

    Directory of Open Access Journals (Sweden)

    Jannie Rossouw

    2011-08-01

    Full Text Available This paper reports a comparison of South African household inflation expectations and inflation credibility surveys undertaken in 2006 and 2008. It tests for possible feed-through between inflation credibility and inflation expectations. It supplements earlier research that focused only on the 2006 survey results. The comparison shows that inflation expectations differed between different income groups in both 2006 and 2008. Inflation credibility differed between male and female respondents, but this difference did not feed through to inflation expectations. More periodic survey data will be required for developing final conclusions on the possibility of feed-through effects. To this end the structure of credibility surveys should be reconsidered, as a large percentage of respondents indicated that they ‘don’t know’ whether the historic rate of inflation is an accurate indication of price increases.

  20. Multifield DBI Inflation and Non-Gaussianities

    CERN Document Server

    Huang, Min-xin; Underwood, Bret

    2008-01-01

    We analyze the trajectories for multifield DBI inflation, which can arise in brane inflation models, and show that the trajectories are the same as in typical slow roll inflation. We calculate the power spectrum and find that the higher derivative terms of the DBI action lead to a suppression of the contribution from the isocurvature perturbations. We also calculate the bispectrum generated by the isocurvature perturbation, and find that it leads to distinctive features.

  1. New Sources of Gravitational Waves During Inflation

    Energy Technology Data Exchange (ETDEWEB)

    Senatore, Leonardo; Silverstein, Eva; /Stanford U., Phys. Dept. /SLAC; Zaldarriaga, Matias; /Princeton, Inst. Advanced Study

    2012-02-15

    We point out that detectable inflationary tensor modes can be generated by particle or string sources produced during inflation, consistently with the requirements for inflation and constraints from scalar fluctuations. We show via examples that this effect can dominate over the contribution from quantum fluctuations of the metric, occurring even when the inflationary potential energy is too low to produce a comparable signal. Thus a detection of tensor modes from inflation does not automatically constitute a determination of the inflationary Hubble scale.

  2. OPENNESS AND INFLATION: EMPIRICAL EVIDENCE FROM INDIA

    OpenAIRE

    Kumar, Neeraj; Kapoor, Vaishali; Poddar, Sugandha

    2014-01-01

    The paper examines the effects of openness on inflation in India. Monthly data from April2004 to December2013 have been used for this purpose. Johansens cointegration approach has been employed to establish the long run (equilibrium) relationship between inflation and openness considering key macroeconomic variables. Empirical results show that a cointegrating relationship among inflation, openness, money supply, interest rate, crude oil price and exchange rate exists. Generalized Forecast Er...

  3. Inflation and Instability of a Polymeric Membrane

    DEFF Research Database (Denmark)

    Neergaard, Jesper; Hassager, Ole

    1999-01-01

    We consider the inflation of an axisymmetric polymeric membrane. Some membranes composed of viscoelastic materials described by a Mooney-Rivlin model show a monotone increasingpressure during inflation. These materialsdevelop a homogeneous membrane thickness in agreement with the Considere......-Pearson condition.Molecularly based models such as the neo-Hookean, Doi-Edwards or Tom-Pom model exhibit a pressure maximum when inflated. Membranes described by these models develop local thinning which may lead to bursting in finite time. Chain branching is found to be a stabilizing factor for a polymer membrane...... undergoing inflation....

  4. Inflation and Failure of Polymeric Membranes

    DEFF Research Database (Denmark)

    Hassager, Ole; Neergaard, Jesper

    2000-01-01

    We consider the inflation of an axisymmetric polymeric membrane.Some membranes composed of viscoelastic materialsdescribed by a Mooney-Rivlin model show a monotone increasingpressure during inflation. These materialsdevelop a homogeneous membrane thickness in agreement with the Considere......-Pearson condition.Molecularly based models such as the neo-Hookean, Doi-Edwardsor Pom-Pom models, as well as the network model recently proposed byMarrucci, exhibit a pressure maximum when inflated. Membranesdescribed by these models develop local thinningwhich may lead to bursting in finite time.Chain branching...... is found to stabilize the inflated polymer membrane....

  5. Chaotic inflation with curvaton induced running

    DEFF Research Database (Denmark)

    Sloth, Martin Snoager

    2014-01-01

    of the apparent tension, but which would be in conflict with prediction of the simplest model of chaotic inflation. The large field chaotic model is sensitive to UV physics, and the nontrivial running of the spectral index suggested by the BICEP2 collaboration could therefore, if true, be telling us some...... additional new information about the UV completion of inflation. However, before we would be able to draw such strong conclusions with confidence, we would first have to also carefully exclude all the alternatives. Assuming monomial chaotic inflation is the right theory of inflation, we therefore explore...

  6. Chaotic inflation in supergravity with Heisenberg symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Antusch, Stefan [Max-Planck-Institut fuer Physik (Werner-Heisenberg-Institut), Foehringer Ring 6, 80805 Muenchen (Germany); Bastero-Gil, Mar [Departamento de Fisica Teorica y del Cosmos and Centro Andaluz de Fisica de Particulas Elementales, Universidad de Granada, 19071 Granada (Spain); Dutta, Koushik [Max-Planck-Institut fuer Physik (Werner-Heisenberg-Institut), Foehringer Ring 6, 80805 Muenchen (Germany)], E-mail: koushik@mppmu.mpg.de; King, Steve F. [School of Physics and Astronomy, University of Southampton, Southampton, SO17 1BJ (United Kingdom); Kostka, Philipp M. [Max-Planck-Institut fuer Physik (Werner-Heisenberg-Institut), Foehringer Ring 6, 80805 Muenchen (Germany)

    2009-09-07

    We propose the introduction of a Heisenberg symmetry of the Kaehler potential to solve the problems with chaotic inflation in supergravity, as a viable alternative to the use of shift symmetry. The slope of the inflaton potential emerges from a small Heisenberg symmetry breaking term in the superpotential. The modulus field of the Heisenberg symmetry is stabilized and made heavy with the help of the large vacuum energy density during inflation. The observable predictions are indistinguishable from those of typical chaotic inflation models, however the form of the inflationary superpotential considered here may be interpreted in terms of sneutrino inflation arising from certain classes of string theory.

  7. Chaotic inflation in supergravity with Heisenberg symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Antusch, Stefan; Dutta, Koushik; Kostka, Philipp M. [Max-Planck-Institut fuer Physik (Werner-Heisenberg-Institut), Foehringer Ring 6, 80805 Muenchen (Germany); Bastero-Gil, Mar [Departamento de Fisica Teorica y del Cosmos, Centro Andaluz de Fisica de Particulas Elementales, Universidad de Granada, 19071 Granada (Spain); King, Steve F. [School of Physics and Astronomy, University of Southampton, Southampton, SO17 1BJ (United Kingdom)

    2010-07-01

    We propose the introduction of a Heisenberg symmetry of the Kaehler potential to solve the problems with chaotic inflation in supergravity, as a viable alternative to the use of shift symmetry. The slope of the inflaton potential emerges from a small Heisenberg symmetry breaking term in the superpotential. The modulus field of the Heisenberg symmetry is stabilized and made heavy with the help of the large vacuum energy density during inflation. The observable predictions are indistinguishable from those of typical chaotic inflation models, however the form of the inflationary superpotential considered here may be interpreted in terms of sneutrino inflation.

  8. Inflation expectations and inflation uncertainty in the Eurozone : Evidence from survey data

    NARCIS (Netherlands)

    Arnold, I.J.M.; Lemmen, J.J.G.

    2006-01-01

    This paper uses the European Commission's Consumer Survey to assess whether inflation expectations have converged and whether inflation uncertainty has diminished following the introduction of the Euro in Europe. Consumers' responses to the survey suggest that inflation expectations depend more on

  9. Inflation expectations and inflation uncertainty in the eurozone : Evidence from survey data

    NARCIS (Netherlands)

    Arnold, I.J.M.; Lemmen, J.J.G.

    2008-01-01

    This paper uses the European Commission’s Consumer Survey to assess whether inflation expectations have converged and whether inflation uncertainty has diminished following the introduction of the euro in Europe. Consumers’ responses to the survey suggest that inflation expectations depend more on

  10. Corpuscular slow-roll inflation

    Science.gov (United States)

    Casadio, Roberto; Giugno, Andrea; Giusti, Andrea

    2018-01-01

    We show that a corpuscular description of gravity can lead to an inflationary scenario similar to Starobinsky's model without requiring the introduction of the inflaton field. All relevant properties are determined by the number of gravitons in the cosmological condensate or, equivalently, by their Compton length. In particular, the relation between the Hubble parameter H and its time derivative H ˙ required by cosmic microwave background observations at the end of inflation, as well as the (minimum) initial value of the slow-roll parameter, are naturally obtained from the Compton size of the condensate.

  11. Foam rigidized inflatable structural assemblies

    Science.gov (United States)

    Tinker, Michael L. (Inventor); Schnell, Andrew R. (Inventor)

    2010-01-01

    An inflatable and rigidizable structure for use as a habitat or a load bearing structure is disclosed. The structure consists of an outer wall and an inner wall defining a containment member and a bladder. The bladder is pressurized to erect the structure from an initially collapsed state. The containment member is subsequently injected with rigidizable fluid through an arrangement of injection ports. Exhaust gases from the curing rigidizable fluid are vented through an arrangement of exhaust ports. The rate of erection can be controlled by frictional engagement with a container or by using a tether. A method for fabricating a tubular structure is disclosed.

  12. Oleic acid vs saline solution lung lavage-induced acute lung injury: effects on lung morphology, pressure-volume relationships, and response to positive end-expiratory pressure.

    Science.gov (United States)

    Luecke, Thomas; Meinhardt, Juergen P; Herrmann, Peter; Weiss, Andreas; Quintel, Michael; Pelosi, Paolo

    2006-08-01

    To compare two lung injury models (oleic acid [OA] and saline solution washout [SW]) regarding lung morphology, regional inflation, and recruitment during static pressure-volume (PV) curves, and the effects of positive end-expiratory pressure (PEEP) below and above the lower inflection point (Pflex). Fourteen adult pigs underwent OA or SW lung injury. Lung volumes were measured using CT. PV curves were obtained with simultaneous CT scanning at lung apex and base. Fractional inflation and recruitment were compared to data on PEEP above and below Pflex. Severity of lung injury was comparable. At zero PEEP, SW showed an increased amount of edema and poorly aerated lung volume, recruitment during inspiration, and a better oxygenation response with PEEP. Whole-lung PV curves were similar in both models, reflecting changes in alveolar inflation or deflation. On the inspiratory PV limb, recruitment and inflation were on the same line, while there was a substantial difference between deflation and derecruitment on the expiratory limb. PEEP-induced recruitment at lung apex and base was at or above the derecruitment line on the expiratory limb and showed no relationship to the whole-lung expiratory PV curve. The following conclusions were made: (1) OA and SW models are comparable in mechanics but not in lung injury characteristics; (2) neither inspiratory nor expiratory whole-lung PV curves are useful to select PEEP in order to optimize recruitment; and (3) after recruitment, there is no difference in derecruitment between the models at high PEEP, while more collapse occurs at lower PEEP in the basal sections of SW lungs.

  13. The Inflation-Hedging Effectiveness of Real Estate

    OpenAIRE

    Jack H. Rubens; Michael T. Bond; James R. Webb

    1989-01-01

    Inflation has become one of the predominant financial concerns of the late twentieth century. In the late 1970s, public opinion polls ranked inflation as the number one problem in the United States. While the rate of inflation has slowed since the late 1970s, inflation is still present and many investors expect a resurgence of inflation to higher levels in the near to immediate future. This continued concern about inflation has led to an increased search and evaluation of investments that wil...

  14. Constrained superfields from inflation to reheating

    Directory of Open Access Journals (Sweden)

    Ioannis Dalianis

    2017-10-01

    Full Text Available We construct effective supergravity theories from customized constrained superfields which provide a setup consistent both for the description of inflation and the subsequent reheating processes. These theories contain the minimum degrees of freedom in the bosonic sector required for single-field inflation.

  15. No-scale SUGRA SO(10) Inflation

    Indian Academy of Sciences (India)

    Ila Garg

    2017-10-09

    Oct 9, 2017 ... Higgs fields for the inflaton. A no-scale SUGRA model of inflation based on the SU(5) GUT using the 24, 5 and. 5 Higgs in the superpotential has been constructed [14]. In the present work, we study inflation in a renormal- izable grand unified theory based on the SO(10) gauge group with no-scale SUGRA.

  16. Inflation Metaphor in Contemporary American English

    Science.gov (United States)

    Hu, Chunyu; Chen, Zhi

    2015-01-01

    Inflation is often regarded as a dangerous phenomenon which poses a potential threat to economies in the world. It is thus an entity that demands the constant attention of economists, policymakers and the general public. In order to make this abstract entry more concrete and vivid, a number of metaphorical expressions are used to depict inflation.…

  17. Demystify Learning Expectations to Address Grade Inflation

    Science.gov (United States)

    Hodges, Linda C.

    2014-01-01

    This article describes the subject of "grade inflation," a reference to educators giving higher grades to student work than their expectations for student achievement warrant. Of the many reasons why this practice happens, Hodges specifically discusses inflating grades as "a natural consequence" when the faculty really…

  18. Inflation Metaphor in the TIME Magazine Corpus

    Science.gov (United States)

    Hu, Chunyu; Liu, Huijie

    2016-01-01

    A historical perspective on economy metaphor can shed new lights on economic thoughts. Based on the TIME Magazine Corpus (TMC), this paper investigates inflation metaphor over 83 years and compares findings against the economic data over the relatively corresponding period. The results show how inflation, an abstract concept and a normal economic…

  19. Grade Inflation: An Issue for Higher Education?

    Science.gov (United States)

    Caruth, Donald L.; Caruth, Gail D.

    2013-01-01

    Grade inflation impacts university credibility, student courses of study, choices of institution, and other areas. There has been an upward shift in grades without a corresponding upward shift in knowledge gained. Some of the most frequently mentioned causes of grade inflation are: (1) student evaluations of professors; (2) student teacher…

  20. Inflation adjustment in the open economy

    DEFF Research Database (Denmark)

    Nielsen, Heino Bohn; Bowdler, Christopher

    2006-01-01

    of these processes cointegrate to I(1). This supports an analysis in which I(1) and I(2) restrictions are imposed. A key finding is that an increase in real import prices reduces productivity adjusted real wages, such that the change in domestic inflation is moderated. This may explain why the depreciation...... of sterling in 1992 left inflation unchanged...

  1. Inflation, large scale structure and particle physics

    Indian Academy of Sciences (India)

    We review experimental and theoretical developments in inflation and its application to structure formation, including the curvation idea. We then discuss a particle physics model of supersymmetric hybrid inflation at the intermediate scale in which the Higgs scalar field is responsible for large scale structure, show how such ...

  2. Brane-world cosmology and inflation

    Indian Academy of Sciences (India)

    will appear an effective non-zero cosmological constant on the brane and the brane may undergo inflation solely due to the dynamics in the bulk [11]. It is therefore interesting to investigate the possibility of inflation on the brane without introducing an inflaton on the brane. For this purpose, let us for simplicity consider a ...

  3. Inflation targeting and interest rate policy

    NARCIS (Netherlands)

    Verhagen, W.H.

    2001-01-01

    The thesis contains a collection of papers on issues in inflation targeting and its implications for the way interest rates are set. In this respect, the first part deals with two largely positive issues: the effect of inflation forecast targeting on the term structure of interest rates and the

  4. Robustness of inflation to inhomogeneous initial conditions

    Science.gov (United States)

    Clough, Katy; Lim, Eugene A.; DiNunno, Brandon S.; Fischler, Willy; Flauger, Raphael; Paban, Sonia

    2017-09-01

    We consider the effects of inhomogeneous initial conditions in both the scalar field profile and the extrinsic curvature on different inflationary models. In particular, we compare the robustness of small field inflation to that of large field inflation, using numerical simulations with Einstein gravity in 3+1 dimensions. We find that small field inflation can fail in the presence of subdominant gradient energies, suggesting that it is much less robust to inhomogeneities than large field inflation, which withstands dominant gradient energies. However, we also show that small field inflation can be successful even if some regions of spacetime start out in the region of the potential that does not support inflation. In the large field case, we confirm previous results that inflation is robust if the inflaton occupies the inflationary part of the potential. Furthermore, we show that increasing initial scalar gradients will not form sufficiently massive inflation-ending black holes if the initial hypersurface is approximately flat. Finally, we consider the large field case with a varying extrinsic curvature K, such that some regions are initially collapsing. We find that this may again lead to local black holes, but overall the spacetime remains inflationary if the spacetime is open, which confirms previous theoretical studies.

  5. 77 FR 19937 - Inflatable Personal Flotation Devices

    Science.gov (United States)

    2012-04-03

    ... Transportation, West Building Ground Floor, Room W12-140, 1200 New Jersey Avenue SE., Washington, DC 20590... using existing inflatable PFDs, and would enable marketing of existing inflatable PFDs to youth. The... approved, and thus does not affect the availability, use, or marketing of existing PFDs to or by the youth...

  6. Inflation Fossils in Cosmic Structure

    Science.gov (United States)

    Kamionkowski, Marc

    The agreement of the predictions of inflation with increasingly precise cosmic microwave background (CMB) and large-scale-structure (LSS) data is remarkable. The notion that such a simple early-Universe scenario, based on still-mysterious ultra-high-energy physics, can explain such a wealth of precise data is simply amazing. An active ongoing program of research is afoot to seek the CMB polarization signatures of inflationary gravitational waves and measure the primordial bispectrum in order to learn about inflation. Still, there is far more that can be done to probe inflationary physics, and no stone should be left unturned in this quest. Here we propose a multi-component program of theoretical research that includes model building, new CMB/LSS tests, a potentially powerful new survey strategy, and the investigation of a new observational avenue for large-scale structure. We propose to broaden the circle of ideas to empirically probe inflation. To begin, the hemispherical power asymmetry seen in WMAP and Planck is truly striking. While it may simply be an unusual statistical fluke, a more tantalizing possibility is that it is a remnant of the pre-inflationary Universe. We propose to develop and study several physical models for this asymmetry and work out other testable predictions of these models. Only by pursuing other signatures of whatever new physics may be responsible for this asymmetry will we be able to infer if it is truly a window to new physics. We also plan to develop departures from statistical isotropy (SI) as a test of inflationary models. We have recently shown that single-field slow-roll inflation generically predicts a quadrupolar departure from SI in primordial perturbations, albeit a very small one. The power quadrupole is expected, however, to be significantly larger in more general inflationary models. We propose to calculate these power quadrupoles so that new constraints to the power quadrupole from CMB and LSS data can be applied to test

  7. Inflation targeting and economic performance: The case of Mexico

    Directory of Open Access Journals (Sweden)

    Carrasco Carlos A.

    2011-01-01

    Full Text Available In the paper we analyze the impact of Inflation Targeting (IT in Mexico. The objective is to evaluate the impact of the implementation of inflation targeting and full-fledged inflation targeting (FFIT on the level and the variability of the inflation and the output in the Mexican economy. We conclude that inflation rates had been reduced in Mexico before the introduction of IT and FFIT. In our opinion, the structural reforms, including the Banxico reforms, are the main determinants of the decrease in inflation and its variability. The main impact of IT would have been the lock-in of inflation expectations around a low rate of inflation.

  8. Vacuum polarization and photon mass in inflation

    CERN Document Server

    Prokopec, T; Prokopec, Tomislav; Woodard, Richard P.

    2004-01-01

    We give a pedagogical review of a mechanism through which long wave length photons can become massive during inflation. Our account begins with a discussion of the period of exponentially rapid expansion known as inflation. We next describe how, when the universe is not expanding, quantum fluctuations in charged particle fields cause even empty space to behave as a polarizable medium. This is the routinely observed phenomenon of vacuum polarization. We show that the quantum fluctuations of low mass, scalar fields are enormously amplified during inflation. If one of these fields is charged, the vacuum polarization effect of flat space is strengthened to the point that long wave length photons acquire mass. Our result for this mass is shown to agree with a simple model in which the massive photon electrodynamics of Proca emerges from applying the Hartree approximation to scalar quantum electrodynamics during inflation. One does not measure a huge photon mass today because the original phase of inflation ended w...

  9. Does string theory lead to extended inflation?

    Science.gov (United States)

    Campbell, Bruce A.; Linde, Andrei; Olive, Keith A.

    1991-05-01

    We consider the relationship between string theory and currently proposed models of extended inflation. In doing so, we discuss the conformal actions in string theory and in Jordan-Brans-Dicke gravity. We show explicitly the equivalence of pictures in which either gauge or gravitational couplings are changing with time. We demonstrate that the existence of the dilation in string theory does not naturally lead to extended inflation as currently discussed. We also discuss the resolution of the graceful exit problem of old inflation in Einstein gravity using either power-law inflation, or exponential inflation with a changing bubble formation rate. On leave of absence from School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA.

  10. Inflation and growth: the international evidence

    Directory of Open Access Journals (Sweden)

    Anthony Philip Thirlwall

    1971-09-01

    Full Text Available Although in the current climate of inflation most are concerned with its negative repercussions, its virtues as a means of growth were once extolled by the likes of Robertson, Kaldor and Rostow. Moreover, the notion of growth via inflation was an attractive proposition to less developed countries in the 1950s as they sought to accelerate the growth of output in the face of inadequate voluntary saving and inelastic tax revenue. Although there are many reasons why in theory mild inflation may be conducive to growth, this hypothesis has yet to be empirically tested. The author analyses a broad cross-section of countries with growth as an independent variable. For both developed and developing countries the hypothesis is supported by the evidence. However, for the latter there is a negative relation between inflation and growth when annual rates of inflation exceed 10 percent.

  11. Towards matter inflation in heterotic string theory

    Energy Technology Data Exchange (ETDEWEB)

    Antusch, Stefan; Erdmenger, Johanna; Halter, Sebastian [Max-Planck-Institut fuer Physik (Werner-Heisenberg-Institut), Muenchen (Germany); Dutta, Koushik [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2011-02-15

    Recently, a class of inflation models in supergravity with gauge non-singlet matter fields as the inflaton has been proposed. It is based on a 'tribrid' structure in the superpotential and on a 'Heisenberg symmetry' for solving the {eta}-problem. We suggest that a generalization of this model class may be suitable for realising inflation in heterotic orbifold compactifications, where the Heisenberg symmetry is a property of the tree-level Kaehler potential of untwisted matter fields. We discuss moduli stabilization in this setup and propose a mechanism to stabilize the modulus associated to the inflaton, which respects the symmetry in the large radius limit. Inflation ends via a waterfall phase transition, as in hybrid inflation. We give conditions which have to be satisfied for realising inflation along these lines in the matter sector of heterotic orbifolds. (orig.)

  12. A two-states Markov-switching model of inflation in France and the USA: credible target VS inflation spiral

    OpenAIRE

    B. HEITZ

    2005-01-01

    This paper seeks to apply the general framework of Markov-switching models to inflation in France and in the USA. We propose a model where inflation can, alternatively, follow two regimes: the first one, where inflation is stationary, is interpreted as a situation where there exists a credible inflation target, even if it is not explicit; the second one where inflation is integrated. Moreover, observing that the two oil shocks were followed by accelerating inflation periods, we allow dependen...

  13. Lung management during cardiopulmonary bypass: influence on extravascular lung water.

    Science.gov (United States)

    Boldt, J; King, D; Scheld, H H; Hempelmann, G

    1990-02-01

    Progressive respiratory insufficiency secondary to cardiopulmonary bypass (CPB) is still a hazard after cardiac surgery. Pathophysiologically, impaired capillary endothelial integrity seems to be the fundamental lesion, followed by increased interstitial fluid accumulation. The reasons for this pulmonary damage are controversial; however, management of the nonperfused lungs during CPB has been widely neglected and may be partly responsible. In this study, 90 patients undergoing coronary artery bypass grafting were randomly divided into six groups (15 patients each) with different management of the lungs during CPB: group 1, lungs collapsed (0/0); group 2, static inflation with +5 cm H2O and F1O2 1.0 (+5/1.0); group 3, static inflation with +5 cm H2O and F1O2 0.21 (+5/0.21); group 4, static inflation with +15 cm H2O and F1O2 1.0 (+15/1.0); group 5, static inflation with +15 cm H2O and F1O2 0.21 (+15/0.21); and group 6, controlled mechanical ventilation as before start of CPB (positive end-expiratory pressure [PEEP] +5 cm H2O; F1O2 1.0) (ventilation). In addition to hemodynamic monitoring, extravascular lung water (EVLW) was measured by means of a double-indicator dilution technique with heat and indocyanine green. Measurements were performed after induction of anesthesia, before onset of CPB, and immediately after weaning from bypass, as well as 60 minutes and 5 hours after termination of CPB. Pulmonary gas exchange (PaO2) and intrapulmonary shunting (Qs/Qt) were also measured. Starting from comparable, normal baseline values, EVLW was increased in all groups after weaning from CPB, with the most pronounced increase in group 4 (maximum, +35%) and group 5 (+40%).(ABSTRACT TRUNCATED AT 250 WORDS)

  14. Inflation in AdS/CFT

    Energy Technology Data Exchange (ETDEWEB)

    Freivogel, Ben; /Stanford U., Phys. Dept. /LBL, Berkeley; Hubeny, Veronika E.; /LBL, Berkeley /Durham U., Dept. of Math.; Maloney, Alexander; /Stanford U., Phys. Dept.; Myers, Rob; /Perimeter Inst. Theor. Phys. /Waterloo U.; Rangamani, Mukund; /LBL, Berkeley /Durham U., Dept. of Math.; Shenker, Stephen; /Stanford U., Phys. Dept.

    2005-10-07

    We study the realization of inflation within the AdS/CFT correspondence. We assume the existence of a string landscape containing at least one stable AdS vacuum and a (nearby) metastable de Sitter state. Standard arguments imply that the bulk physics in the vicinity of the AdS minimum is described by a boundary CFT. We argue that large enough bubbles of the dS phase, including those able to inflate, are described by mixed states in the CFT. Inflating degrees of freedom are traced over and do not appear explicitly in the boundary description. They nevertheless leave a distinct imprint on the mixed state. Analytic continuation allows us, in principle, to recover a large amount of nonperturbatively defined information about the inflating regime. Our work also shows that no scattering process can create an inflating region, even by quantum tunneling, since a pure state can never evolve into a mixed state under unitary evolution.We study the realization of inflation within the AdS/CFT correspondence. We assume the existence of a string landscape containing at least one stable AdS vacuum and a (nearby) metastable de Sitter state. Standard arguments imply that the bulk physics in the vicinity of the AdS minimum is described by a boundary CFT. We argue that large enough bubbles of the dS phase, including those able to inflate, are described by mixed states in the CFT. Inflating degrees of freedom are traced over and do not appear explicitly in the boundary description. They nevertheless leave a distinct imprint on the mixed state. Analytic continuation allows us, in principle, to recover a large amount of nonperturbatively defined information about the inflating regime. Our work also shows that no scattering process can create an inflating region, even by quantum tunneling, since a pure state can never evolve into a mixed state under unitary evolution.

  15. Ultrasound-induced lung hemorrhage: Role of acoustic boundary conditions at the pleural surface

    Science.gov (United States)

    O'Brien, William D.; Kramer, Jeffrey M.; Waldrop, Tony G.; Frizzell, Leon A.; Miller, Rita J.; Blue, James P.; Zachary, James F.

    2002-02-01

    In a previous study [J. Acoust. Soc. Am. 108, 1290 (2000)] the acoustic impedance difference between intercostal tissue and lung was evaluated as a possible explanation for the enhanced lung damage with increased hydrostatic pressure, but the hydrostatic-pressure-dependent impedance difference alone could not explain the enhanced occurrence of hemorrhage. In that study, it was hypothesized that the animal's breathing pattern might be altered as a function of hydrostatic pressure, which in turn might affect the volume of air inspired and expired. The acoustic impedance difference between intercostal tissue and lung would be affected with altered lung inflation, thus altering the acoustic boundary conditions. In this study, 12 rats were exposed to 3 volumes of lung inflation (inflated: approximately tidal volume; half-deflated: half-tidal volume; deflated: lung volume at functional residual capacity), 6 rats at 8.6-MPa in situ peak rarefactional pressure (MI of 3.1) and 6 rats at 16-MPa in situ peak rarefactional pressure (MI of 5.8). Respiration was chemically inhibited and a ventilator was used to control lung volume and respiratory frequency. Superthreshold ultrasound exposures of the lungs were used (3.1-MHz, 1000-Hz PRF, 1.3-μs pulse duration, 10-s exposure duration) to produce lesions. Deflated lungs were more easily damaged than half-deflated lungs, and half-deflated lungs were more easily damaged than inflated lungs. In fact, there were no lesions observed in inflated lungs in any of the rats. The acoustic impedance difference between intercostal tissue and lung is much less for the deflated lung condition, suggesting that the extent of lung damage is related to the amount of acoustic energy that is propagated across the pleural surface boundary.

  16. Mechanical ventilation after lung transplantation.

    Science.gov (United States)

    Thakuria, Louit; Davey, Rosada; Romano, Rosalba; Carby, Martin R; Kaul, Sundeep; Griffiths, Mark J; Simon, André R; Reed, Anna K; Marczin, Nandor

    2016-02-01

    To explore the hypothesis that early ventilation strategies influence clinical outcomes in lung transplantation, we have examined our routine ventilation practices in terms of tidal volumes (Vt) and inflation pressures. A total of 124 bilateral lung transplants between 2010 and 2013 were retrospectively assigned to low (8 mL/kg) Vt groups based on ventilation characteristics during the first 6 hours after surgery. Those same 124 patients were also stratified to low-pressure (<25 cm H2O) and high-pressure (≥25 cm H2O) groups. Eighty percent of patients were ventilated using pressure control mode. Low, medium, and high Vt were applied to 10%, 43%, and 47% of patients, respectively. After correcting for patients requiring extracorporeal support, there was no difference in short-term to midterm outcomes among the different Vt groups. Low inflation pressures were applied to 61% of patients, who had a shorter length of intensive care unit stay (5 vs 12 days; P = .012), higher forced expiratory volume in 1 second at 3 months (77.8% vs 60.3%; P < .001), and increased 6-month survival rate (95% vs 77%; P = .008). Low Vt ventilation has not been fully adopted in our practice. Ventilation with higher inflation pressures, but not Vt, was significantly associated with poorer outcomes after lung transplantation. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Systematics of constant roll inflation

    Science.gov (United States)

    Anguelova, Lilia; Suranyi, Peter; Wijewardhana, L. C. R.

    2018-02-01

    We study constant roll inflation systematically. This is a regime, in which the slow roll approximation can be violated. It has long been thought that this approximation is necessary for agreement with observations. However, recently it was understood that there can be inflationary models with a constant, and not necessarily small, rate of roll that are both stable and compatible with the observational constraint ns ≈ 1. We investigate systematically the condition for such a constant-roll regime. In the process, we find a whole new class of inflationary models, in addition to the known solutions. We show that the new models are stable under scalar perturbations. Finally, we find a part of their parameter space, in which they produce a nearly scale-invariant scalar power spectrum, as needed for observational viability.

  18. Cosmological Inflation: A Personal Perspective

    Science.gov (United States)

    Kazanas, Demos

    2008-01-01

    We present a brief review of Cosmological Inflation from the personal perspective of the speaker who almost 30 years ago proposed a way of resolving the problem of Cosmological Horizon by employing certain notions and developments from the field of High Energy Physics. Along with a brief introduction of the Horizon and Flatness problems of standard cosmology, this lecture concentrates on personal reminiscing of the notions and ideas that prevailed and influenced the author's thinking at the time. The lecture then touches upon some more recent developments related to the subject including exact solutions to conformal gravity that provide a first principles emergence of a characteristic acceleration in the universe and concludes with some personal views concerning the direction that the cosmology field has taken in the past couple of decades and certain speculations some notions that may indicate future directions of research.

  19. MSSM-inspired multifield inflation

    Science.gov (United States)

    Dubinin, M. N.; Petrova, E. Yu.; Pozdeeva, E. O.; Sumin, M. V.; Vernov, S. Yu.

    2017-12-01

    Despite the fact that experimentally with a high degree of statistical significance only a single Standard Model-like Higgs boson is discovered at the LHC, extended Higgs sectors with multiple scalar fields not excluded by combined fits of the data are more preferable theoretically for internally consistent realistic models of particle physics. We analyze the inflationary scenarios which could be induced by the two-Higgs-doublet potential of the Minimal Supersymmetric Standard Model (MSSM) where five scalar fields have non-minimal couplings to gravity. Observables following from such MSSM-inspired multifield inflation are calculated and a number of consistent inflationary scenarios are constructed. Cosmological evolution with different initial conditions for the multifield system leads to consequences fully compatible with observational data on the spectral index and the tensor-to-scalar ratio. It is demonstrated that the strong coupling approximation is precise enough to describe such inflationary scenarios.

  20. String moduli inflation. An overview

    Energy Technology Data Exchange (ETDEWEB)

    Cicoli, Michele [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Quevedo, Fernando [Cambridge Univ. (United Kingdom). DAMTP/CMS; Abdus Salam International Centre for Theoretical Physics, Trieste (Italy)

    2011-06-15

    We present an overview of inflationary models derived from string theory focusing mostly on closed string moduli as inflatons. After a detailed discussion of the {eta}-problem and different approaches to address it, we describe possible ways to obtain a de Sitter vacuum with all closed string moduli stabilised. We then look for inflationary directions and present some of the most promising scenarios where the inflatons are either the real or the imaginary part of Kaehler moduli. We pay particular attention on extracting potential observable implications, showing how most of the scenarios predict negligible gravitational waves and could therefore be ruled out by the Planck satellite. We conclude by briefly mentioning some open challenges in string cosmology beyond deriving just inflation. (orig.)

  1. Clustering fossils in solid inflation

    Energy Technology Data Exchange (ETDEWEB)

    Akhshik, Mohammad, E-mail: m.akhshik@ipm.ir [Department of Physics, Sharif University of Technology, Tehran (Iran, Islamic Republic of)

    2015-05-01

    In solid inflation the single field non-Gaussianity consistency condition is violated. As a result, the long tenor perturbation induces observable clustering fossils in the form of quadrupole anisotropy in large scale structure power spectrum. In this work we revisit the bispectrum analysis for the scalar-scalar-scalar and tensor-scalar-scalar bispectrum for the general parameter space of solid. We consider the parameter space of the model in which the level of non-Gaussianity generated is consistent with the Planck constraints. Specializing to this allowed range of model parameter we calculate the quadrupole anisotropy induced from the long tensor perturbations on the power spectrum of the scalar perturbations. We argue that the imprints of clustering fossil from primordial gravitational waves on large scale structures can be detected from the future galaxy surveys.

  2. Why most discovered true associations are inflated.

    Science.gov (United States)

    Ioannidis, John P A

    2008-09-01

    Newly discovered true (non-null) associations often have inflated effects compared with the true effect sizes. I discuss here the main reasons for this inflation. First, theoretical considerations prove that when true discovery is claimed based on crossing a threshold of statistical significance and the discovery study is underpowered, the observed effects are expected to be inflated. This has been demonstrated in various fields ranging from early stopped clinical trials to genome-wide associations. Second, flexible analyses coupled with selective reporting may inflate the published discovered effects. The vibration ratio (the ratio of the largest vs. smallest effect on the same association approached with different analytic choices) can be very large. Third, effects may be inflated at the stage of interpretation due to diverse conflicts of interest. Discovered effects are not always inflated, and under some circumstances may be deflated-for example, in the setting of late discovery of associations in sequentially accumulated overpowered evidence, in some types of misclassification from measurement error, and in conflicts causing reverse biases. Finally, I discuss potential approaches to this problem. These include being cautious about newly discovered effect sizes, considering some rational down-adjustment, using analytical methods that correct for the anticipated inflation, ignoring the magnitude of the effect (if not necessary), conducting large studies in the discovery phase, using strict protocols for analyses, pursuing complete and transparent reporting of all results, placing emphasis on replication, and being fair with interpretation of results.

  3. Taxation, Fiscal Deficit and Inflation in Pakistan

    Directory of Open Access Journals (Sweden)

    Ghulam Rasool Madni

    2014-09-01

    Full Text Available Fiscal policy has more controversial debate regarding its effectiveness on different macroeconomic activities of an economy. Taxation and government expenditure are two main instruments of fiscal policy. This paper is aimed to analyze and update the effects of different instruments of fiscal policy on inflation in Pakistan economy. The data time span for this study is 1979-2013. The impact of fiscal policy on inflation is analyzed by utilizing the Bounds testing procedure and ARDL approach of co-integration which is a better estimation technique for small sample size. It is found that investment negatively and significantly affect the inflation rate. The outcomes of the study show that both types of taxes (direct and indirect are causing to increase the inflation level while fiscal deficit is also one of the reasons to increase the inflation in the country. The study proposed that government should decrease the level of expenditure to reduce the level of fiscal deficit and investment have to be promoted to decrease the inflation in the country. Furthermore, it is also suggested to decrease the level of taxation for controlling inflation.

  4. An evaluation of inflation expectations in Turkey

    Directory of Open Access Journals (Sweden)

    Barış Soybilgen

    2017-03-01

    Full Text Available Expectations of inflation play a critical role in the process of price setting in the market. Central banks closely follow developments in inflation expectations to implement a successful monetary policy. The Central Bank of the Republic of Turkey (CBRT conducts a survey of experts and decision makers in the financial and real sectors to reveal market expectations and predictions of current and future inflation. The survey is conducted every month. This paper examines the accuracy of these survey predictions using forecast evaluation techniques. We focus on both point and sign accuracy of the predictions. Although point predictions from CBRT surveys are compared with those of autoregressive models, sign predictions are evaluated on their value to a user. We also test the predictions for bias. Unlike the empirical evidence from other economies, our results show that autoregressive models outperform most of inflation expectations in forecasting inflation. This indicates that inflation expectations have poor point forecast accuracies. However, we show that sign predictions for all inflation expectations have value to a user.

  5. The expected anisotropy in solid inflation

    Energy Technology Data Exchange (ETDEWEB)

    Bartolo, Nicola; Ricciardone, Angelo [Dipartimento di Fisica e Astronomia ' ' G. Galilei' ' , Università degli Studi di Padova, via Marzolo 8, I-35131, Padova (Italy); Peloso, Marco; Unal, Caner, E-mail: nicola.bartolo@pd.infn.it, E-mail: peloso@physics.umn.edu, E-mail: angelo.ricciardone@pd.infn.it, E-mail: unal@physics.umn.edu [School of Physics and Astronomy, University of Minnesota, 116 Church Street S.E., Minneapolis 55455 (United States)

    2014-11-01

    Solid inflation is an effective field theory of inflation in which isotropy and homogeneity are accomplished via a specific combination of anisotropic sources (three scalar fields that individually break isotropy). This results in specific observational signatures that are not found in standard models of inflation: a non-trivial angular dependence for the squeezed bispectrum, and a possibly long period of anisotropic inflation (to drive inflation, the ''solid'' must be very insensitive to any deformation, and thus background anisotropies are very slowly erased). In this paper we compute the expected level of statistical anisotropy in the power spectrum of the curvature perturbations of this model. To do so, we account for the classical background values of the three scalar fields that are generated on large (superhorizon) scales during inflation via a random walk sum, as the perturbation modes leave the horizon. Such an anisotropy is unavoidably generated, even starting from perfectly isotropic classical initial conditions. The expected level of anisotropy is related to the duration of inflation and to the amplitude of the squeezed bispectrum. If this amplitude is close to its current observational limit (so that one of the most interesting predictions of the model can be observed in the near future), we find that a level of statistical anisotropy F{sup 2} gives frozen and scale invariant vector perturbations on superhorizon scales.

  6. Rand volatility and inflation in South Africa

    Directory of Open Access Journals (Sweden)

    Azwifaneli Innocentia (Mulaudzi Nemushu

    2017-01-01

    Full Text Available The floating exchange rate regime, coupled with a more open trade policy and the growth in imports, leaves South Africa vulnerable to the effects of exchange rate behaviour on import, producer and consumer prices, which all contribute to inflation. Given the central role that inflation targeting occupies in South Africa’s monetary policy, this paper examines the effect of exchange rate shocks on consumer prices using monthly data covering the period January 1994 to December 2013. Consistent with developing countries story, results show a modest exchange rate pass-through to inflation, although inflation is mainly driven by own shocks. The variance decompositions also reveal that foreign exchange rate shocks (REER contribute relatively more to inflation than money supply shocks (M3. This suggests that South African inflation process is not basically influenced by money supply changes. The practical implication is that that the volatility of the rand is not a serious threat to inflation. The SARB should therefore focus on price stability and not be unduly worried about the volatility of the rand.

  7. Macroeconomic susceptibility, inflation, and aggregate supply

    Science.gov (United States)

    Hawkins, Raymond J.

    2017-03-01

    We unify aggregate-supply dynamics as a time-dependent susceptibility-mediated relationship between inflation and aggregate economic output. In addition to representing well various observations of inflation-output dynamics this parsimonious formalism provides a straightforward derivation of popular representations of aggregate-supply dynamics and a natural basis for economic-agent expectations as an element of inflation formation. Our formalism also illuminates questions of causality and time-correlation that challenge central banks for whom aggregate-supply dynamics is a key constraint in their goal of achieving macroeconomic stability.

  8. Chaotic inflation of the Universe in supergravity

    Energy Technology Data Exchange (ETDEWEB)

    Goncharov, A.S.; Linde, A.D.

    1984-05-01

    A new realization of the chaotic inflation scenario of the Universe is suggested in the context of the models based on N=1 supergravity. In this scenario one can obtain sufficiently large inflation of the Universe and the necessary magnitude of density inhomogeneities, which appear after inflation and give rise to the galaxy formation. In the models under consideration the superpotential of matter fields can be made negligibly small in the absolute minimum of the effective potential, which is necessary in order to solve the interaction hierarchy problem in these models.

  9. Stability of inflation processes with polymer melts

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz; Eriksson, Torbjörn Gerhard; Hassager, Ole

    2002-01-01

    The production process Blow-moulding is used to produce different kinds of bottles in plastic. The final stage in this process is the inflation of some kind of (extruded or injection moulded) cylinder outward against the wall of the mould. This creates the final shape of the product. The inflation...... is performed applying a gas pressure into the core of the cylinder, which press the molten plastic cylinder outward. During the inflation the plastic may burst. The occurrence of this burst, or break, puts a limit on the possibility to produce a specified product at some, or all, processing conditions. Here...

  10. Planck 2015 results: XX. Constraints on inflation

    DEFF Research Database (Denmark)

    Ade, P. A R; Aghanim, N.; Arnaud, M.

    2016-01-01

    We present the implications for cosmic inflation of the Planck measurements of the cosmic microwave background (CMB) anisotropies in both temperature and polarization based on the full Planck survey, which includes more than twice the integration time of the nominal survey used for the 2013 release...... a joint analysis of the BICEP2/Keck Array and Planck data. These results imply that V(φ) â φ2 and natural inflation are now disfavoured compared to models predicting a smaller tensor-to-scalar ratio, such as R2 inflation. We search for several physically motivated deviations from a simple power...

  11. Non-Gaussianity from Axion Monodromy Inflation

    DEFF Research Database (Denmark)

    Hannestad, Steen; Haugboelle, Troels; R. Jarnhus, Philip

    2010-01-01

    We study the primordial non-Gaussinity predicted from simple models of inflation with a linear potential and superimposed oscillations. This generic form of the potential is predicted by the axion monodromy inflation model, that has recently been proposed as a possible realization of chaotic...... inflation in string theory, where the monodromy from wrapped branes extends the range of the closed string axions to beyond the Planck scale. The superimposed oscillations in the potential can lead to new signatures in the CMB spectrum and bispectrum. In particular the bispectrum will have a new distinct...

  12. Inflation and Instability of a Polymeric Membrane

    DEFF Research Database (Denmark)

    Neergaard, Jesper; Hassager, Ole

    1999-01-01

    We consider an axisymmetric polymeric membrane inflated by a uniform pressure difference acting across the membrane. The polymeric materialis described by an arbitrary combination of a viscoelastic and a purely viscous component to the stress. Some viscoelastic materials described by a Mooney......-Rivlin model show a monotone increasingpressure during inflation of a spherical membrane. These materials develop a homogeneous membrane thickness in agreement with the Considere-Pearson condition. Molecularly based models such as the neo-Hookean, Doi-Edwards or Tom-Pom model show a pressure maximum when...... inflated. Membranesdescribed by these models develop a local thinning of the membrane which may lead to bursting in finite time....

  13. Reconstruction of constant slow-roll inflation

    Science.gov (United States)

    Gao, Qing

    2017-09-01

    Using the relations between the slow-roll parameters and the power spectra for the single field slow-roll inflation, we derive the scalar spectral tilt n s and the tensor to scalar ratio r for the constant slow-roll inflation, and obtain the constraint on the slow-roll parameter η from the Planck 2015 results. The inflationary potential for the constant slow-roll inflation is then reconstructed in the framework of both general relativity and the scalar-tensor theory of gravity, and compared with the recently reconstructed E model potential. In the strong coupling limit, we show that the η attractor is reached.

  14. 21 CFR 876.3350 - Penile inflatable implant.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Penile inflatable implant. 876.3350 Section 876...) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Prosthetic Devices § 876.3350 Penile inflatable implant. (a) Identification. A penile inflatable implant is a device that consists of two inflatable cylinders...

  15. On the burst of branched polymer melts during inflation

    DEFF Research Database (Denmark)

    Rasmussen, Henrik K.; Yu, Kaijia

    2008-01-01

    Two molten low-density polyethylene melts, shaped as plates, have been inflated into a circular cylinder during isothermal conditions. Lowering the inflation rates allow the plates to be inflated into a larger volume of the cylinder before bursting. Numerical simulations of the inflations have been...

  16. 78 FR 5760 - Civil Monetary Penalty Inflation Adjustment

    Science.gov (United States)

    2013-01-28

    ... Department of the Army, Corps of Engineers 33 CFR Part 326 RIN 0710-AA66 Civil Monetary Penalty Inflation... Clean Water Act and the National Fishing Enhancement Act to account for inflation. The adjustment of civil penalties to account for inflation is required by the Federal Civil Penalties Inflation Adjustment...

  17. Introduction of Inflation Linked Bond in Nigeria: Prospects and ...

    African Journals Online (AJOL)

    Protection against inflation is an essential part of contemporary financial markets, particularly in high-inflation economies like Nigeria. Nowadays, inflation linked instruments are becoming popular in the world financial markets. The objective of this paper is to examine the issues that may arise if inflation linked bond are ...

  18. 77 FR 65100 - Adjustment of Civil Monetary Penalties for Inflation

    Science.gov (United States)

    2012-10-25

    ... COMMISSION 17 CFR Part 143 RIN 3038-AD76 Adjustment of Civil Monetary Penalties for Inflation AGENCY... inflation. This rule sets forth the maximum, inflation-adjusted dollar amount for civil monetary penalties... and orders thereunder. The rule, as amended, implements the Federal Civil Penalties Inflation...

  19. 46 CFR 506.3 - Civil monetary penalty inflation adjustment.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Civil monetary penalty inflation adjustment. 506.3... PENALTY INFLATION ADJUSTMENT § 506.3 Civil monetary penalty inflation adjustment. The Commission shall... each civil monetary penalty provided by law within the jurisdiction of the Commission by the inflation...

  20. 78 FR 49370 - Inflation Adjustment of Maximum Forfeiture Penalties

    Science.gov (United States)

    2013-08-14

    ... COMMISSION 47 CFR Part 1 Inflation Adjustment of Maximum Forfeiture Penalties AGENCY: Federal Communications... for inflation. The inflation adjustment is necessary to implement the Debt Collection Improvement Act... established in that section to account for inflation since the last adjustment to these penalties. The...

  1. Monetary policy and heterogeneous inflation expectations in South Africa

    NARCIS (Netherlands)

    Kabundi, A.; Schaling, E.; Some, M.

    2015-01-01

    This paper examines the relationship between inflation and inflation expectations of analysts, business, and trade unions in South Africa during the inflation targeting (IT) regime. We consider inflation expectations based on the Bureau of Economic Research (BER) quarterly survey observed from

  2. 78 FR 5722 - Civil Monetary Penalty Inflation Adjustment

    Science.gov (United States)

    2013-01-28

    ... Department of the Army, Corps of Engineers 33 CFR Part 326 RIN 0710-AA66 Civil Monetary Penalty Inflation... Clean Water Act and the National Fishing Enhancement Act to account for inflation. The adjustment of civil penalties to account for inflation is required by the Federal Civil Penalties Inflation Adjustment...

  3. 12 CFR 263.65 - Civil penalty inflation adjustments.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Civil penalty inflation adjustments. 263.65... Money Penalties § 263.65 Civil penalty inflation adjustments. (a) Inflation adjustments. In accordance with the Federal Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note), the Board has...

  4. Eternal extended inflation and graceful exit from old inflation without Jordan-Brans-Dicke

    Science.gov (United States)

    Linde, Andrei

    1990-10-01

    Recently a possible solution to the graceful exit problem of the old inflation was proposed in the context of the Jordan-Brans-Dicke theory (extended inflation). In this paper we will argue that inflation in this theory occurs in a most natural way if it starts near the Planck density, as in the standard version of chaotic inflation. With most natural initial conditions, the inflationary universe in the JBD theory enters the stage of permanent reproduction of new inflationary domains (eternal extended inflation). In order to realize the extended inflation scenario at least two classical scalar fields driving inflation are necessary, as distinct from the simplest versions of new and chaotic inflation. It is shown that in the theory of two scalar fields one can solve the graceful exit problem even without modifying the Einstein gravity theory, due to the possibility that the decay rate of the false rate vacuum in old inflation depends on the value of the second scalar field and hence on time. Address after 1 September 1990: Physics Department, Stanford University, Varian Building, Stanford, CA 94305, USA.

  5. IAS15 inflation adjustments and EVA: empirical evidence from a highly variable inflation regime

    Directory of Open Access Journals (Sweden)

    Pierre Erasmus

    2011-08-01

    Full Text Available Inflation can have a pronounced effect on the financial performance of a firm. This study makes inflation adjustments to a firm’s cost of sales, depreciation, level of gearing and assets in line with International Accounting Standard 15 (IAS15 in order to calculate an inflation-adjusted version of the economic value added (EVA measure. The study was conducted using data from South African industrial firms during a period characterised by highly variable inflation levels (1991-2005. The results indicate that during this period there were significant differences between the nominal and real values of the firms’ EVAs

  6. The accuracy of delivery of target pressures using self-inflating bag manometers in a benchtop study.

    Science.gov (United States)

    Rafferty, Anthony R; Johnson, Lucy; Maxfield, Dominic; Dawson, Jennifer A; Davis, Peter G; Thio, Marta

    2016-06-01

    We tested whether operators using manometers attached to self-inflating bags could accurately deliver set targeted peak inspiratory pressures (PIPs) compared to the Neopuff(™) T-piece resuscitator (TPR). Participants provided positive pressure ventilation to a leak-free neonatal test lung at a rate of 60 inflations/min and a flow of 8 L/min. Participants used three manometers attached to self-inflating bags and a Neopuff(™) TPR to target PIPs of 20, 30 and 40 cmH2 O on each device. Mean PIPs delivered with each manometer were compared to the 'gold standard' Neopuff(™) TPR. In total, 13 991 inflations delivered by 20 participants were analysed. At all target PIPs, the mean PIP delivered using the Mercury Medical manometer attached to a Laerdal self-inflating bag was significantly higher by 5 cmH2 O (p inflating bag is used during manual ventilation. This may be useful in settings where access to a Neopuff(™) TPR or a gas flow source is limited. ©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  7. 76 FR 60405 - Inflatable Personal Flotation Devices

    Science.gov (United States)

    2011-09-29

    ... Plastic Film and Sheeting), because those standards, or equivalent test methods, are referenced in UL 1191... use by adults only'' would create a perception that inflatable PFDs for youth would be available on...

  8. Revisiting the minimal chaotic inflation model

    Energy Technology Data Exchange (ETDEWEB)

    Harigaya, Keisuke, E-mail: keisukeharigaya@berkeley.edu [ICRR, University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Ibe, Masahiro; Kawasaki, Masahiro [ICRR, University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Kavli IPMU (WPI), UTIAS, University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Yanagida, Tsutomu T. [Kavli IPMU (WPI), UTIAS, University of Tokyo, Kashiwa, Chiba 277-8583 (Japan)

    2016-05-10

    We point out that the prediction of the minimal chaotic inflation model is altered if a scalar field takes a large field value close to the Planck scale during inflation due to a negative Hubble induced mass. In particular, we show that the inflaton potential is effectively flattened at a large inflaton field value in the presence of such a scalar field. The scalar field may be identified with the standard model Higgs field or super partners of standard model fermions. With such Hubble-induced flattening, we find that the minimal chaotic inflation model, especially the model with a quadratic potential, is consistent with recent observations of the cosmic microwave background fluctuation without modifying the inflation model itself.

  9. Inflation in DoD Medical Care

    National Research Council Canada - National Science Library

    Goldberg, Matthew

    1997-01-01

    .... A variety of inflation indices are used in updating the DHP budget requirement. This paper evaluates the appropriateness of those indices, and identifies alternative indices that are theoretically superior to those currently in use...

  10. Integrated Inflatable Ballute for Planetary Entry Project

    Data.gov (United States)

    National Aeronautics and Space Administration — CFDRC and TRLA are proposing to develop, design and test a highly scalable, mass-optimized inflatable structure that makes maximum utilization of materials in...

  11. Integrated Inflatable Ballute for Planetary Entry Project

    Data.gov (United States)

    National Aeronautics and Space Administration — CFDRC and TRLA are proposing to develop, design, and test a mass-optimized isotensoid inflatable structure that makes maximum utilization of materials in providing...

  12. Higher Curvature Supergravity, Supersymmetry Breaking and Inflation

    CERN Document Server

    Ferrara, Sergio

    2017-01-01

    In these lectures, after a short introduction to cosmology, we discuss the supergravity embedding of higher curvature models of inflation. The supergravity description of such models is presented for the two different formulations of minimal supergravity.

  13. Rotating mandrel speeds assembly of plastic inflatables

    Science.gov (United States)

    Mac Fadden, J. A.; Stenlund, S. J.; Wendt, A. J.

    1966-01-01

    Rotating mandrel permits the accurate cutting, forming, and sealing of plastic gores for assembly of an inflatable surface of revolution. The gores remain on the mandrel until the final seam is reached. Tolerances are tightly controlled by the mandrel configuration.

  14. Cosmological perturbations in transient phantom inflation scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Richarte, Martin G. [Universidade Federal do Parana, Departamento de Fisica, Caixa Postal 19044, Curitiba (Brazil); Universidad de Buenos Aires, Ciudad Universitaria 1428, Departamento de Fisica, Facultad de Ciencias Exactas y Naturales, Buenos Aires (Argentina); Kremer, Gilberto M. [Universidade Federal do Parana, Departamento de Fisica, Caixa Postal 19044, Curitiba (Brazil)

    2017-01-15

    We present a model of inflation where the inflaton is accommodated as a phantom field which exhibits an initial transient pole behavior and then decays into a quintessence field which is responsible for a radiation era. We must stress that the present unified model only deals with a single field and that the transition between the two eras is achieved in a smooth way, so the model does not suffer from the eternal inflation issue. We explore the conditions for the crossing of the phantom divide line within the inflationary era along with the structural stability of several critical points. We study the behavior of the phantom field within the slow-climb approximation along with the necessary conditions to have sufficient inflation. We also examine the model at the level of classical perturbations within the Newtonian gauge and determine the behavior of the gravitational potential, contrast density and perturbed field near the inflation stage and the subsequent radiation era. (orig.)

  15. Democracy: A Determinant Factor in Reducing Inflation

    National Research Council Canada - National Science Library

    Mohamed Fenira

    2014-01-01

    .... The purpose of this paper is to extend the range of explanatory factors in explaining macroeconomic pathologies and to demonstrate that democracy is an important instrument in reducing inflation...

  16. Higher Curvature Supergravity, Supersymmetry Breaking and Inflation

    Science.gov (United States)

    Ferrara, Sergio; Kehagias, Alex

    In these lectures, after a short introduction to cosmology, we discuss the supergravity embedding of higher curvature models of inflation. The supergravity description of such models is presented for the two different formulations of minimal supcrgravity.

  17. Revisiting the minimal chaotic inflation model

    Directory of Open Access Journals (Sweden)

    Keisuke Harigaya

    2016-05-01

    Full Text Available We point out that the prediction of the minimal chaotic inflation model is altered if a scalar field takes a large field value close to the Planck scale during inflation due to a negative Hubble induced mass. In particular, we show that the inflaton potential is effectively flattened at a large inflaton field value in the presence of such a scalar field. The scalar field may be identified with the standard model Higgs field or super partners of standard model fermions. With such Hubble-induced flattening, we find that the minimal chaotic inflation model, especially the model with a quadratic potential, is consistent with recent observations of the cosmic microwave background fluctuation without modifying the inflation model itself.

  18. Sustainable one-step synthesis of hierarchical microspheres of PEGylated MoS2 nanosheets and MoO3 nanorods: Their cytotoxicity towards lung and breast cancer cells

    Science.gov (United States)

    Kumar, Neeraj; George, Blassan Plackal Adimuriyil; Abrahamse, Heidi; Parashar, Vyom; Ngila, Jane Catherine

    2017-02-01

    Nanotechnology provides an emerging potent alternate mode of cancer therapy. Nanomaterials dispersion or solubility is of particular concern in utilising their full potential applications in biomedical fields. PEGylation of nanomaterials is considered to provide products with stealth properties, and physiological environment with no obvious adverse effects. The purpose of this work was to develop a sustainable one-step method for fabrication of hierarchical microspheres of PEGylated MoS2 nanosheets using a stoichiometric ratio of Mo(VI) and thiourea. This study further investigated the cytotoxicity of the PEGylated MoS2 nanosheets towards lung (A549) and breast cancer (MCF-7) cell lines by analysing morphological changes and performing dose-dependent cell proliferation, and cytotoxicity analysis using adenosine 5‧-triphosphate (ATP), and lactate dehydrogenase (LDH) assay. For comparison, MoO3 nanorods were synthesised by simple chemical route and their cytotoxicity towards lung (A549) and breast cancer (MCF-7) cell lines were checked. The findings suggested that PEGylated MoS2 nanosheets have excellent cytotoxicity towards breast cancer (MCF-7) cell lines, and MoO3 have better cytotoxicity towards lung (A549) cancer cell lines. This work envisages an accessible foundation for engineering sophisticated biomolecule-MoS2 nanosheets conjugation due to the defect-rich biocompatible surface, to achieve great versatility, additional functions, and further advances in the biomedical field.

  19. The Properties of Survey-Based Inflation Expectations in Sweden

    OpenAIRE

    Jonsson, Thomas; Österholm, Pär

    2009-01-01

    This paper assesses the properties of survey-based inflation expectations in Sweden. The survey is conducted by Prospera once every quarter and consists of respondents from businesses and labour-market organisa-tions. The paper shows that inflation expectations measured in this sur-vey tend to be biased and inefficient forecasts of future inflation. Results also indicate that long-run inflation expectations are overly adaptive with respect to actual inflation. Finally, evaluations of forecast...

  20. Inflation of universe due to nonlinear electrodynamics

    Science.gov (United States)

    Kruglov, S. I.

    2017-05-01

    A model of nonlinear electrodynamics with a dimensional parameter β is considered. Electromagnetic fields are the source of the gravitation field and inflation of the universe. We imply that the universe is filled by stochastic magnetic fields. It is demonstrated that after the universe inflation the universe decelerates approaching the Minkowski space-time. We evaluate the spectral index, the tensor-to-scalar ratio, and the running of the spectral index which approximately agree with the Planck and WMAP data.

  1. Effect of inflation on anisotropic cosmologies

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, L.G.; Stein-Schabes, J.A.

    1986-03-01

    The effects of anisotropic cosmologies on inflation are studied. By properly formulating the field equations it is possible to show that any model that undergoes sufficient inflation will become isotropic on scales greater than the horizon today. Furthermore, we shall show that it takes a very long time for anisotropies to become visible in the observable part of the Universe. It is interesting to note that the time scale will be independent of the Bianchi Model and of the initial anisotropy. 6 refs.

  2. Statistical Methods for Base Inflation Calculation

    Directory of Open Access Journals (Sweden)

    Ion Partachi

    2007-02-01

    Full Text Available The purposes of the given research are the analysis of four alternative methods of measurement of base inflation and a choice of the parameter most precisely reflecting an actual inflationary trend in the Republic of Moldova. The estimation of the fact sheet on inflation in the Republic of Moldova is made with application of the approach based on methods of the statistical analysis, in particular: exclusion method, trimmed means method, standard deviation trimmed means method, percentile method.

  3. Inflation and pseudo-Goldstone Higgs boson

    DEFF Research Database (Denmark)

    Alanne, Tommi; Sannino, Francesco; Tenkanen, Tommi

    2017-01-01

    We consider inflation within a model framework where the Higgs boson arises as a pseudo-Goldstone boson associated with the breaking of a global symmetry at a scale significantly larger than the electroweak one. We show that in such a model the scalar self-couplings can be parametrically suppressed...... field. Our model therefore suggests that inflation and low energy particle phenomenology may be more entwined than assumed so far....

  4. Finite temperature effects in primordial inflation

    Science.gov (United States)

    Gelmini, G. B.; Nanopoulos, D. V.; Olive, K. A.

    1983-11-01

    We present a detailed study of a recently proposed model for primordial inflation based on an N=1 locally supersymmetric potential. For a large class of parameters with which all cosmological constraints are satisfied, the temperature corrections can be neglected during the inflation period. At higher temperatures, the minimum is not at the origin, but very close to it. Address after July 1, 1983: Theory Group, Fermilab, PO Box 500, Batavia, IL 60510, USA.

  5. Gravitino problem in minimal supergravity inflation

    Directory of Open Access Journals (Sweden)

    Fuminori Hasegawa

    2017-04-01

    Full Text Available We study non-thermal gravitino production in the minimal supergravity inflation. In this minimal model utilizing orthogonal nilpotent superfields, the particle spectrum includes only graviton, gravitino, inflaton, and goldstino. We find that a substantial fraction of the cosmic energy density can be transferred to the longitudinal gravitino due to non-trivial change of its sound speed. This implies either a breakdown of the effective theory after inflation or a serious gravitino problem.

  6. Gravitino problem in minimal supergravity inflation

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Fuminori [Institute for Cosmic Ray Research, The University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Mukaida, Kyohei [Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Nakayama, Kazunori [Department of Physics, Faculty of Science, The University of Tokyo, Bunkyo-ku, Tokyo 133-0033 (Japan); Terada, Takahiro, E-mail: terada@kias.re.kr [School of Physics, Korea Institute for Advanced Study (KIAS), Seoul 02455 (Korea, Republic of); Yamada, Yusuke [Stanford Institute for Theoretical Physics and Department of Physics, Stanford University, Stanford, CA 94305 (United States)

    2017-04-10

    We study non-thermal gravitino production in the minimal supergravity inflation. In this minimal model utilizing orthogonal nilpotent superfields, the particle spectrum includes only graviton, gravitino, inflaton, and goldstino. We find that a substantial fraction of the cosmic energy density can be transferred to the longitudinal gravitino due to non-trivial change of its sound speed. This implies either a breakdown of the effective theory after inflation or a serious gravitino problem.

  7. Social Security's Five OASI Inflation Indexing Problems

    OpenAIRE

    Michael C. Lovell

    2009-01-01

    This paper examines five problems with the inflation indexing procedures used by the Social Security Administration of the United States in taking inflation into account when calculating Old Age and Survivors Insurance (OASI) Benefits. Because of Problem #1, the commingling of unindexed with indexed earnings, a retiree born in 1930 who continued in a high earning career until age 75 receives an annual benefit more than $1,800 larger than would have been generated with full indexing. As a resu...

  8. On stability of electroweak vacuum during inflation

    Directory of Open Access Journals (Sweden)

    A. Shkerin

    2015-06-01

    Full Text Available We study Coleman–De Luccia tunneling of the Standard Model Higgs field during inflation in the case when the electroweak vacuum is metastable. We verify that the tunneling rate is exponentially suppressed. The main contribution to the suppression is the same as in flat space–time. We analytically estimate the corrections due to the expansion of the universe and an effective mass term in the Higgs potential that can be present at inflation.

  9. Instrumentation for the Characterization of Inflatable Structures

    Science.gov (United States)

    Swanson, Gregory T.; Cassell, Alan M.; Johnson, R. Keith

    2012-01-01

    Current entry, descent, and landing technologies are not practical for heavy payloads due to mass and volume constraints dictated by limitations imposed by launch vehicle fairings. Therefore, new technologies are now being explored to provide a mass- and volume-efficient solution for heavy payload capabilities, including Inflatable Aerodynamic Decelerators (IAD) [1]. Consideration of IADs for space applications has prompted the development of instrumentation systems for integration with flexible structures to characterize system response to flight-like environment testing. This development opportunity faces many challenges specific to inflatable structures in extreme environments, including but not limited to physical flexibility, packaging, temperature, structural integration and data acquisition [2]. In the spring of 2012, two large scale Hypersonic Inflatable Aerodynamic Decelerators (HIAD) will be tested in the National Full-Scale Aerodynamics Complex s 40 by 80 wind tunnel at NASA Ames Research Center. The test series will characterize the performance of a 3.0 m and 6.0 m HIAD at various angles of attack and levels of inflation during flight-like loading. To analyze the performance of these inflatable test articles as they undergo aerodynamic loading, many instrumentation systems have been researched and developed. These systems will utilize new experimental sensing systems developed by the HIAD ground test campaign instrumentation team, in addition to traditional wind tunnel sensing techniques in an effort to improve test article characterization and model validation. During the 2012 test series the instrumentation systems will target inflatable aeroshell static and dynamic deformation, structural strap loading, surface pressure distribution, localized skin deflection, and torus inflation pressure. This paper will offer an overview of inflatable structure instrumentation, and provide detail into the design and implementation of the sensors systems that will

  10. Inflation in the standard cosmological model

    Science.gov (United States)

    Uzan, Jean-Philippe

    2015-12-01

    The inflationary paradigm is now part of the standard cosmological model as a description of its primordial phase. While its original motivation was to solve the standard problems of the hot big bang model, it was soon understood that it offers a natural theory for the origin of the large-scale structure of the universe. Most models rely on a slow-rolling scalar field and enjoy very generic predictions. Besides, all the matter of the universe is produced by the decay of the inflaton field at the end of inflation during a phase of reheating. These predictions can be (and are) tested from their imprint of the large-scale structure and in particular the cosmic microwave background. Inflation stands as a window in physics where both general relativity and quantum field theory are at work and which can be observationally studied. It connects cosmology with high-energy physics. Today most models are constructed within extensions of the standard model, such as supersymmetry or string theory. Inflation also disrupts our vision of the universe, in particular with the ideas of chaotic inflation and eternal inflation that tend to promote the image of a very inhomogeneous universe with fractal structure on a large scale. This idea is also at the heart of further speculations, such as the multiverse. This introduction summarizes the connections between inflation and the hot big bang model and details the basics of its dynamics and predictions. xml:lang="fr"

  11. Inflation and Growth: Positive or Negative Relationship?

    Science.gov (United States)

    Berument, Hakan; Inamlik, Ali; Olgun, Hasan

    This study has been motivated by two developments. Firstly, by the vast literature on the relationship between inflation and growth which is abundantly endowed with diverse theoretical explanations and contradictory evidence and by the unique experience of the Turkish economy with inflation and growth. A preliminary examination of the Turkish data pointed to a negative relation between inflation and growth. Moreover, there is a unanimous agreement among the students of the Turkish economy that many factors have contributed to inflation in this country. In view of these facts this paper employs a VAR model which will enable us to identify the sources of the shocks and control for external factors. In addition VAR models have a high predictive power and enable the researcher to observe the impulse response functions. The study employs Generalised Impulse Response analysis. In the empirical experiments oil prices, money supply, government spending and taxes have been taken as the most likely determinants of inflation. The study shows that there is a negative relationship between inflation and output growth in Turkey and that the underlying explanatory factor is the real exchange rate. This result is robust.

  12. On corpuscular theory of inflation

    Energy Technology Data Exchange (ETDEWEB)

    Berezhiani, Lasha [Princeton University, Department of Physics, Princeton, NJ (United States)

    2017-02-15

    In order to go beyond the mean-field approximation, commonly used in the inflationary computations, an identification of the quantum constituents of the inflationary background is made. In particular, the homogeneous scalar field configuration is represented as a Bose-Einstein condensate of the off-shell inflaton degrees of freedom, with mass significantly screened by the gravitational binding energy. The gravitational counterpart of the classical background is considered to be a degenerate state of the off-shell longitudinal gravitons with the frequency of the order of the Hubble scale. As a result, the origin of the density perturbations in the slow-roll regime is identified as an uncertainty in the position of the constituent inflatons. While in the regime of eternal inflation, the scattering of the constituent gravitons becomes the relevant source of the density perturbations. The gravitational waves, on the other hand, originate from the annihilation of the constituent longitudinal gravitons at all energy scales. This results in the quantum depletion of the classical background, leading to the upper bound on the number of e-folds, after which the semi-classical description is expected to break down; this is estimated to be of the order of the entropy of the initial Hubble patch. (orig.)

  13. Holographic framework for eternal inflation

    Science.gov (United States)

    Freivogel, Ben; Sekino, Yasuhiro; Susskind, Leonard; Yeh, Chen-Pin

    2006-10-01

    In this paper we provide some circumstantial evidence for a holographic duality between bubble nucleation in an eternally inflating universe and a Euclidean conformal field theory (CFT). The holographic correspondence (which is different than Strominger’s de Sitter (dS)/CFT duality) relates the decay of (3+1)-dimensional de Sitter space to a two-dimensional CFT. It is not associated with pure de Sitter space, but rather with Coleman-De Luccia bubble nucleation. Alternatively, it can be thought of as a holographic description of the open, infinite, Friedmann-Robertson-Walker (FRW) cosmology that results from such a bubble. The conjectured holographic representation is of a new type that combines holography with the Wheeler-DeWitt formalism to produce a Wheeler-DeWitt theory that lives on the spatial boundary of a k=-1 FRW cosmology. We also argue for a more ambitious interpretation of the Wheeler-DeWitt CFT as a holographic dual of the entire Landscape.

  14. Eternal inflation with Liouville cosmology

    Science.gov (United States)

    Nakayama, Yu

    2011-05-01

    We present a concrete holographic realization of the eternal inflation in (1+1)-dimensional Liouville gravity by applying the philosophy of the FRW/CFT correspondence proposed by Freivogel, Sekino, Susskind and Yeh (FSSY). The dual boundary theory is nothing but the old matrix model describing the two-dimensional Liouville gravity coupled with minimal model matter fields. In Liouville gravity, the flat Minkowski space or even the AdS space will decay into the dS space, which is in stark contrast with higher-dimensional theories, but the spirit of the FSSY conjecture applies with only minimal modification. We investigate the classical geometry as well as some correlation functions to support our claim. We also study an analytic continuation to the time-like Liouville theory to discuss possible applications in (1+3)-dimensional cosmology along with the original FSSY conjecture, where the boundary theory involves the time-like Liouville theory. We show that the decay rate in the (1+3) dimension is more suppressed due to the quantum gravity correction of the boundary theory.

  15. Inflating with Large Effective Fields

    CERN Document Server

    Burgess, C P; Quevedo, F; Williams, M

    2014-01-01

    We re-examine large scalar fields within effective field theory, in particular focussing on the issues raised by their use in inflationary models (as suggested by BICEP2 to obtain primordial tensor modes). We argue that when the large-field and low-energy regimes coincide the scalar dynamics is most effectively described in terms of an asymptotic large-field expansion whose form can be dictated by approximate symmetries, which also help control the size of quantum corrections. We discuss several possible symmetries that can achieve this, including pseudo-Goldstone inflatons characterized by a coset $G/H$ (based on abelian and non-abelian, compact and non-compact symmetries), as well as symmetries that are intrinsically higher dimensional. Besides the usual trigonometric potentials of Natural Inflation we also find in this way simple {\\em large-field} power laws (like $V \\propto \\phi^2$) and exponential potentials, $V(\\phi) = \\sum_{k} V_k \\; e^{-k \\phi/M}$. Both of these can describe the data well and give slo...

  16. Brane Bremsstrahlung in DBI Inflation

    CERN Document Server

    Brax, Philippe

    2010-01-01

    We consider the effect of trapped branes on the evolution of a test brane whose motion generates DBI inflation along a warped throat. The coupling between the inflationary brane and a trapped brane leads to the radiation of non-thermal particles on the trapped brane. We calculate the Gaussian spectrum of the radiated particles and their backreaction on the DBI motion of the inflationary brane. Radiation occurs for momenta lower than the speed of the test brane when crossing the trapped brane. The slowing down effect is either due to a parametric resonance when the interaction time is small compared to the Hubble time or a tachyonic resonance when the interaction time is large. In both cases the motion of the inflationary brane after the interaction is governed by a chameleonic potential,which tends to slow it down. We find that a single trapped brane can hardly slow down a DBI inflaton whose fluctuations lead to the Cosmic Microwave Background spectrum. A more drastic effect is obtained when the DBI brane enc...

  17. Authorship Inflation in Medical Publications

    Directory of Open Access Journals (Sweden)

    Gaurie Tilak BA

    2015-07-01

    Full Text Available The number of authors per manuscript in peer-reviewed medical journals has increased substantially in the last several decades. Several reasons have been offered to explain this authorship growth, including increased researcher collaboration, honorary authorship driven by increased pressures for funding and promotion, the belief that including senior authors will facilitate publication, and the growing complexity of medical research. It is unknown, however, whether authorship has grown over time due to growing complexity of published academic articles, in which case growth could be warranted, or whether it has grown due to pressures of funding and academic promotion, which have created “authorship inflation.” To answer this question, we analyzed data on authorship count, study type, and size of study population for the first 50 original articles published in each decade during 1960-2010 in 3 major medical journals. Within each type of study we considered (eg, randomized trials, observational studies, etc, average authorship rose more than 3-fold during this period. Similar growth persisted after adjustment for changes in study population sizes over time. Our findings suggest that increasing research complexity is an inadequate explanation for authorship growth. Instead, growth in authorship appears inflationary.

  18. Inflation and cosmological parameter estimation

    Energy Technology Data Exchange (ETDEWEB)

    Hamann, J.

    2007-05-15

    In this work, we focus on two aspects of cosmological data analysis: inference of parameter values and the search for new effects in the inflationary sector. Constraints on cosmological parameters are commonly derived under the assumption of a minimal model. We point out that this procedure systematically underestimates errors and possibly biases estimates, due to overly restrictive assumptions. In a more conservative approach, we analyse cosmological data using a more general eleven-parameter model. We find that regions of the parameter space that were previously thought ruled out are still compatible with the data; the bounds on individual parameters are relaxed by up to a factor of two, compared to the results for the minimal six-parameter model. Moreover, we analyse a class of inflation models, in which the slow roll conditions are briefly violated, due to a step in the potential. We show that the presence of a step generically leads to an oscillating spectrum and perform a fit to CMB and galaxy clustering data. We do not find conclusive evidence for a step in the potential and derive strong bounds on quantities that parameterise the step. (orig.)

  19. Geometric Tachyon and Warm Inflation

    Science.gov (United States)

    Bhattacharjee, Anindita; Deshamukhya, Atri

    2013-03-01

    The inflationary models developed in presence of a background radiation can be a solution to the reheating problem faced by common cold (isentropic) inflationary scenario. A D-brane system comprising of k Neuvo-Schwarz (NS) 5-branes with a transverse circle and BPS D3-branes with world volume parallel to the NS 5-branes, placed at a point on the transverse circle diametrically to NS 5-brane has a point of unstable equilibrium and the D3-brane has a geometric tachyonic mode associated with displacement of the brane along the circle. Cold inflationary scenario has been studied in connection with this geometric tachyon [S. Panda, M. Sami and S. Tsujikawa, Phys. Rev. D73, 023515 (2006)] where it was found that one needs a background of minimum 104 branes to realize a viable inflationary model. In this piece of work, we have tried to study a model of inflation driven by this geometric tachyon in presence of radiation. We have found that compared to the isentropic scenario, to satisfy the observational bounds, the number of background branes required in this case reduces drastically and a viable model can be obtained with even six to seven NS 5-branes in the background. In this context, we have also analyzed the non-gaussianity associated with the model and observed that the concerned parameter lies well within the observation limit.

  20. Plasticity of lung development in the amphibian, Xenopus laevis

    Directory of Open Access Journals (Sweden)

    Christopher S. Rose

    2013-10-01

    Contrary to previous studies, we found that Xenopus laevis tadpoles raised in normoxic water without access to air can routinely complete metamorphosis with lungs that are either severely stunted and uninflated or absent altogether. This is the first demonstration that lung development in a tetrapod can be inhibited by environmental factors and that a tetrapod that relies significantly on lung respiration under unstressed conditions can be raised to forego this function without adverse effects. This study compared lung development in untreated, air-deprived (AD and air-restored (AR tadpoles and frogs using whole mounts, histology, BrdU labeling of cell division and antibody staining of smooth muscle actin. We also examined the relationship of swimming and breathing behaviors to lung recovery in AR animals. Inhibition and recovery of lung development occurred at the stage of lung inflation. Lung recovery in AR tadpoles occurred at a predictable and rapid rate and correlated with changes in swimming and breathing behavior. It thus presents a new experimental model for investigating the role of mechanical forces in lung development. Lung recovery in AR frogs was unpredictable and did not correlate with behavioral changes. Its low frequency of occurrence could be attributed to developmental, physical and behavioral changes, the effects of which increase with size and age. Plasticity of lung inflation at tadpole stages and loss of plasticity at postmetamorphic stages offer new insights into the role of developmental plasticity in amphibian lung loss and life history evolution.

  1. Sustainable one-step synthesis of hierarchical microspheres of PEGylated MoS{sub 2} nanosheets and MoO{sub 3} nanorods: Their cytotoxicity towards lung and breast cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Neeraj [Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028, South Africa, (South Africa); George, Blassan Plackal Adimuriyil; Abrahamse, Heidi [Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein 2028 (South Africa); Parashar, Vyom, E-mail: vyomparashar@gmail.com [Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028, South Africa, (South Africa); Ngila, Jane Catherine, E-mail: jcngila@uj.ac.za [Department of Applied Chemistry, University of Johannesburg, Doornfontein 2028, South Africa, (South Africa)

    2017-02-28

    Highlights: • Microspheres of PEGylated MoS{sub 2} nanosheets were synthesised by hydrothermal route. • PEGylated MoS{sub 2} have shown good cytotoxicity towards breast cancer (MCF-7) cells. • For comparison, h-MoO{sub 3} nanorods were prepared by simple chemical route. • h-MoO{sub 3} have exhibited excellent cytotoxicity towards lung (A549) cancer cells. - Abstract: Nanotechnology provides an emerging potent alternate mode of cancer therapy. Nanomaterials dispersion or solubility is of particular concern in utilising their full potential applications in biomedical fields. PEGylation of nanomaterials is considered to provide products with stealth properties, and physiological environment with no obvious adverse effects. The purpose of this work was to develop a sustainable one-step method for fabrication of hierarchical microspheres of PEGylated MoS{sub 2} nanosheets using a stoichiometric ratio of Mo(VI) and thiourea. This study further investigated the cytotoxicity of the PEGylated MoS{sub 2} nanosheets towards lung (A549) and breast cancer (MCF-7) cell lines by analysing morphological changes and performing dose-dependent cell proliferation, and cytotoxicity analysis using adenosine 5′-triphosphate (ATP), and lactate dehydrogenase (LDH) assay. For comparison, MoO{sub 3} nanorods were synthesised by simple chemical route and their cytotoxicity towards lung (A549) and breast cancer (MCF-7) cell lines were checked. The findings suggested that PEGylated MoS{sub 2} nanosheets have excellent cytotoxicity towards breast cancer (MCF-7) cell lines, and MoO{sub 3} have better cytotoxicity towards lung (A549) cancer cell lines. This work envisages an accessible foundation for engineering sophisticated biomolecule–MoS{sub 2} nanosheets conjugation due to the defect-rich biocompatible surface, to achieve great versatility, additional functions, and further advances in the biomedical field.

  2. Changes in Inflation Dynamics under Inflation Targeting? Evidence from Central European Countries

    Czech Academy of Sciences Publication Activity Database

    Baxa, Jaromír; Plašil, M.; Vašíček, B.

    2013-01-01

    Roč. 11, č. 1 (2013), s. 2-5 ISSN 1803-7089 Institutional support: RVO:67985556 Keywords : Inflation Dynamics * Inflation Targeting? Subject RIV: AH - Economics http://library.utia.cas.cz/separaty/2013/E/baxa-0395372.pdf

  3. Estimation of Inflationary Expectations and the Effectiveness of Inflation Targeting Strategy

    Directory of Open Access Journals (Sweden)

    Amalia CRISTESCU

    2011-02-01

    Full Text Available The credibility and accountability of a central bank, acting in an inflation targeting regime, are essential because they allow a sustainable anchoring of the inflationary anticipation of economic agents. Their decisions and behavior will increasingly be grounded on information provided by the central bank, especially if it shows transparency in the process of communicating with the public. Thus, inflationary anticipations are one of the most important channels through which the monetary policy affects the economic activity. They are crucial in the formation of the consumer prices among producers and traders, especially since it is relatively expensive for the economic agents to adjust their prices at short intervals. That is why many central banks use response functions containing inflationary anticipations, in their inflation targeting models. The most frequently problem in relation to these anticipations is that they are based on the assumption of optimal forecasts of future inflation, which are, implicitly, rational anticipations. In fact, the economic agents’ inflationary anticipations are most often adaptive or even irrational. Thus, rational anticipations cannot be used to estimate equations for the Romanian economy because the agents who form their expectations do not have sufficient information and an inflationary environment stable enough to fully anticipate the inflation evolution. The inflation evolution in the Romanian economy helps to calculate adaptive forecasts for which the weight of the "forward looking" component has to be rather important. The economic agents form their inflation expectations for periods of time that, usually, coincide with a production cycle (one year and consider the official and unofficial inflation forecasts present on the market in order to make strategic decisions. Thus, in recent research on inflation modeling, actual inflationary anticipations of economic agents which are revealed based on national

  4. CATCHING INFLATION BY THE TAIL – Animal metaphoric imagery in the conceptualisation of INFLATION in English

    Directory of Open Access Journals (Sweden)

    Nadežda Silaški

    2010-10-01

    Full Text Available ANIMAL metaphors are conventional in many languages and their metaphorical use is not limited only to human beings, non-physical domains may also be understood in terms of the assumed properties of animals. Set within the wider theoretical framework of Cognitive Theory of Metaphor, this paper deals with the conceptualisation of INFLATION as an ANIMAL in English. We focus on the INFLATION IS A FEROCIOUS ANIMAL metaphor, in which the most salient properties of wild animals as a source domain are mapped onto the abstract and complex target domain, INFLATION, producing various conceptual mappings, which refer to the ways wild animals move, look, sound, eat/are fed, attack and are controlled. We show how the INFLATION IS A FEROCIOUS ANIMAL metaphor functions within popular economic discourse, as well as how it structures our thinking about inflation, a dangerous phenomenon which poses a potential threat to every economy in the world.

  5. Inflatable Wing project personnel prepare a deployable, inflatable wing technology demonstrator expe

    Science.gov (United States)

    2001-01-01

    Inflatable Wing project personnel prepare a deployable, inflatable wing technology demonstrator experiment flown by the NASA Dryden Flight Research Center, Edwards, California. The inflatable wing project represented a basic flight research effort by Dryden personnel. Three successful flights of the I2000 inflatable wing aircraft occurred. During the flights, the team air-launched the radio-controlled (R/C) I2000 from an R/C utility airplane at an altitude of 800-1000 feet. As the I2000 separated from the carrier aircraft, its inflatable wings 'popped-out,' deploying rapidly via an on-board nitrogen bottle. The aircraft remained stable as it transitioned from wingless to winged flight. The unpowered I2000 glided down to a smooth landing under complete control.

  6. Dual-Compartment Inflatable Suitlock

    Science.gov (United States)

    Kennedy, Kriss J.; Guirgis, Peggy L.; Boyle, Robert M.

    2013-01-01

    There is a need for an improvement over current NASA Extravehicular Activity (EVA) technology. The technology must allow the capacity for quicker, more efficient egress/ingress, allow for shirtsleeve suit maintenance, be compact in transport, and be applicable to environments ranging from planetary surface (partial-g) to orbital or deep space zero-g environments. The technology must also be resistant to dust and other foreign contaminants that may be present on or around a planetary surface. The technology should be portable, and be capable of docking with a variety of habitats, ports, stations, vehicles, and other pressurized modules. The Dual-Compartment Inflatable Suitlock (DCIS) consists of three hard inline bulkheads, separating two cylindrical membrane-walled compartments. The Inner Bulkhead can be fitted with a variety of hatch types, docking flanges, and mating hardware, such as the Common Berthing Mechanism (CBM), for the purpose of mating with vehicles, habitats, and other pressurized modules. The Inner Bulkhead and Center Bulkhead function as the end walls of the Inner Compartment, which during operations, would stay pressurized, either matching the pressure of the habitat or acting as a lower-pressure transitional volume. The Inner Compartment contains donning/doffing fixtures and inner suit-port hatches. The Center Bulkhead has two integrated suit-ports along with a maintenance hatch. The Center Bulkhead and Outer Bulkhead function as the end walls of the Outer Compartment, which stays at vacuum during normal operations. This allows the crewmember to quickly don a suit, and egress the suitlock without waiting for the Outer Compartment to depressurize. The Outer Compartment can be pressurized infrequently for both nominal and off-nominal suit maintenance tasks, allowing shirtsleeve inspections and maintenance/repair of the environmental suits. The Outer Bulkhead has a pressure-assisted hatch door that stays open and stowed during EVA operations, but can

  7. On the bursting of linear polymer melts in inflation processes

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz; Bach, Anders

    2005-01-01

    Molten LLDPE and HDPE plates (thickness 2 mm) have been inflated into a circular cylinder (inner radius 31 mm) under isothermal conditions. Low deformation rates allow the plates to be inflated considerably into the cylinder, and at high inflation rates an early burst is observed. Axis-symmetric ......Molten LLDPE and HDPE plates (thickness 2 mm) have been inflated into a circular cylinder (inner radius 31 mm) under isothermal conditions. Low deformation rates allow the plates to be inflated considerably into the cylinder, and at high inflation rates an early burst is observed. Axis...

  8. Inflation Responses to Commodity Price Shocks; How and Why Do Countries Differ?

    OpenAIRE

    R. G Gelos; Yulia Ustyugova

    2012-01-01

    This paper relates the inflationary impact of commodity price shocks across countries to a broad range of structural characteristics and policy frameworks over the period 2001-2010, using several approaches. The analysis suggests that economies with higher food shares in CPI baskets, fuel intensities, and pre-existing inflation levels were more prone to experience sustained inflationary effects from commodity price shocks. Countries with more independent central banks and higher governance sc...

  9. Rheological properties of excised rabbit lung stiffened by repeated hyperinflation.

    Science.gov (United States)

    Nagao, K; Ardila, R; Hildebrandt, J

    1979-08-01

    Two rheological properties, stress adpatation (S) and hysteresis loop area (H), were studied in normal fresh rabbit lungs and in lungs stiffened by 3 hr repeated inflation at zero end-expiratory pressure. S was measured on the deflation limb at various volume levels ranging from 100 to 25% total lung capacity (TLC). H was obtained in another group of lungs before and after stiffening, for tidal volumes ranging from 5 to 30% TLC, at end-expiratory levels from 25 to 70% TLC. In stiff lung, S after deflation from TLC was biphasic (initial pressure rise, then a fall) whenever the starting pressure exceeded approximately 10 cmH2O. At low lung volumes (25% TLC) stress rose monotonically toward 10 cmH2O. Only monontonic adaptation has previously been reported for normal lung. Tidal H in stiff lungs was increased at all volume levels, occupying roughly 20% of a bounding pressure-volume rectangle, resembling that of normal lungs near TLC but twice that of normal loops at lower volumes. The results suggest that above an equilibrium or transition pressure around 10 cmH2O the alveolar lining in stiff lung may have film properties more resembling those of a viscous liquid, becoming solidlike below this pressure. Similar viscous liquid properties appear to exist on the inflation limb of normal lungs, and near TLC on their deflation limb.

  10. Relic gravitational waves from quintessential inflation

    Science.gov (United States)

    Ahmad, Safia; Myrzakulov, R.; Sami, M.

    2017-09-01

    We study relic gravitational waves in the paradigm of quintessential inflation. In this framework, irrespective of the underlying model, inflation is followed by the kinetic regime. Thereafter, the field energy density remains subdominant before the onset of acceleration. We carry out model-independent analysis to obtain the temperature at the end of inflation and the estimate for the upper bound on the Hubble parameter to circumvent the problem due to relic gravitational waves. In this process, we use Planck 2015 data to constrain the inflationary phase. We demonstrate that the required temperature can be produced by the mechanism of instant preheating. The generic feature of the scenario includes the presence of the kinetic regime after inflation, which results in the blue spectrum of gravitational wave background at high frequencies. We discuss the prospects of detection of relic gravitational wave background in the advanced LIGO and LISA space-born gravitational wave missions. Finally, we consider a concrete model to realize the paradigm of quintessential inflation and show that inflationary as well as postinflationary evolution can be successfully described by the inflaton potential, V (ϕ )∝Exp (-λ ϕn/MPln)(n >1 ) , by suitably constraining the parameters of the model.

  11. Interest and Inflation Risk: Investor Behavior.

    Science.gov (United States)

    González, María de la O; Jareño, Francisco; Skinner, Frank S

    2016-01-01

    We examine investor behavior under interest and inflation risk in different scenarios. To that end, we analyze the relation between stock returns and unexpected changes in nominal and real interest rates and inflation for the US stock market. This relation is examined in detail by breaking the results down from the US stock market level to sector, sub-sector, and to individual industries as the ability of different industries to absorb unexpected changes in interest rates and inflation can vary by industry and by contraction and expansion sub-periods. While most significant relations are conventionally negative, some are consistently positive. This suggests some relevant implications on investor behavior. Thus, investments in industries with this positive relation can form a safe haven from unexpected changes in real and nominal interest rates. Gold has an insignificant beta during recessionary conditions hinting that Gold can be a safe haven during recessions. However, Gold also has a consistent negative relation to unexpected changes in inflation thereby damaging the claim that Gold is a hedge against inflation.

  12. New type of hill-top inflation

    Energy Technology Data Exchange (ETDEWEB)

    Barvinsky, A.O. [Theory Department, Lebedev Physics Institute,Leninsky Prospect 53, Moscow 119991 (Russian Federation); Department of Physics, Tomsk State University,Lenin Ave. 36, Tomsk 634050 (Russian Federation); Department of Physics and Astronomy, Pacific Institue for Theoretical Physics,University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); Kamenshchik, A.Yu. [Dipartimento di Fisica and INFN,via Irnerio 46, 40126 Bologna (Italy); L.D. Landau Institute for Theoretical Physcis,Kosygin str. 2, 119334 Moscow (Russian Federation); Nesterov, D.V. [Theory Department, Lebedev Physics Institute,Leninsky Prospect 53, Moscow 119991 (Russian Federation)

    2016-01-20

    We suggest a new type of hill-top inflation originating from the initial conditions in the form of the microcanonical density matrix for the cosmological model with a large number of quantum fields conformally coupled to gravity. Initial conditions for inflation are set up by cosmological instantons describing underbarrier oscillations in the vicinity of the inflaton potential maximum. These periodic oscillations of the inflaton field and cosmological scale factor are obtained within the approximation of two coupled oscillators subject to the slow roll regime in the Euclidean time. This regime is characterized by rapid oscillations of the scale factor on the background of a slowly varying inflaton, which guarantees smallness of slow roll parameters ϵ and η of the following inflation stage. A hill-like shape of the inflaton potential is shown to be generated by logarithmic loop corrections to the tree-level asymptotically shift-invariant potential in the non-minimal Higgs inflation model and R{sup 2}-gravity. The solution to the problem of hierarchy between the Planckian scale and the inflation scale is discussed within the concept of conformal higher spin fields, which also suggests the mechanism bringing the model below the gravitational cutoff and, thus, protecting it from large graviton loop corrections.

  13. Observational constraints on Tachyon and DBI inflation

    Science.gov (United States)

    Li, Sheng; Liddle, Andrew R.

    2014-03-01

    We present a systematic method for evaluation of perturbation observables in non-canonical single-field inflation models within the slow-roll approximation, which allied with field redefinitions enables predictions to be established for a wide range of models. We use this to investigate various non-canonical inflation models, including Tachyon inflation and DBI inflation. The Lambert Script W function will be used extensively in our method for the evaluation of observables. In the Tachyon case, in the slow-roll approximation the model can be approximated by a canonical field with a redefined potential, which yields predictions in better agreement with observations than the canonical equivalents. For DBI inflation models we consider contributions from both the scalar potential and the warp geometry. In the case of a quartic potential, we find a formula for the observables under both non-relativistic (sound speed cs2 ~ 1) and relativistic behaviour (cs2 ll 1) of the scalar DBI inflaton. For a quadratic potential we find two branches in the non-relativistic cs2 ~ 1 case, determined by the competition of model parameters, while for the relativistic case cs2 → 0, we find consistency with results already in the literature. We present a comparison to the latest Planck satellite observations. Most of the non-canonical models we investigate, including the Tachyon, are better fits to data than canonical models with the same potential, but we find that DBI models in the slow-roll regime have difficulty in matching the data.

  14. Lung cancer

    Science.gov (United States)

    ... it is called metastatic cancer to the lung . Causes Lung cancer is the deadliest type of cancer for both ... under age 45. Cigarette smoking is the leading cause of lung cancer. The more cigarettes you smoke per day and ...

  15. Lung surgery

    Science.gov (United States)

    ... cavity, particularly after trauma Surgery to remove small balloon-like tissues (blebs) that cause lung collapse ( pneumothorax ) ... this surgery include: Failure of the lung to expand Injury to the lungs or blood vessels Need ...

  16. Primordial gravitational waves in supersolid inflation

    Science.gov (United States)

    Ricciardone, Angelo; Tasinato, Gianmassimo

    2017-07-01

    Supersolid inflation is a class of inflationary theories that simultaneously breaks time and space reparametrization invariance during inflation, with distinctive features for the dynamics of cosmological fluctuations. We investigate concrete realizations of such a scenario, including non-minimal couplings between gravity and the fields driving inflation. We focus in particular on the dynamics of primordial gravitational waves and discuss how their properties depend on the pattern of symmetry breaking that we consider. Tensor modes can have a blue spectrum, and for the first time we build models in which the squeezed limit of primordial tensor bispectra can be parametrically enhanced with respect to standard single-field scenarios. At leading order in a perturbative expansion, the tensor-to-scalar ratio depends only on the parameter controlling the breaking of space reparametrization. It is independent from the quantities controlling the breaking of time reparametrization, and this represents a difference with respect to standard single-field inflationary models.

  17. Inflation after COBE: Lectures on inflationary cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Turner, M.S. [Chicago Univ., IL (United States). Enrico Fermi Inst.]|[Fermi National Accelerator Lab., Batavia, IL (United States)

    1992-12-31

    In these lectures I review the standard hot big-bang cosmology, emphasizing its successes, its shortcomings, and its major challenge-a detailed understanding of the formation of structure in the Universe. I then discuss the motivations for and the fundamentals of inflationary cosmology, particularly emphasizing the quantum origin of metric (density and gravity-wave) perturbations. Inflation addresses the shortcomings of the standard cosmology and provides the ``initial data`` for structure formation. I conclude by addressing the implications of inflation for structure formation, evaluating the various cold dark matter models in the light of the recent detection of temperature anisotropies in the cosmic background radiation by COBE. In the near term, the study of structure formation offers a powerful probe of inflation, as well as specific inflationary models.

  18. Inflation after COBE: Lectures on inflationary cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Turner, M.S. (Chicago Univ., IL (United States). Enrico Fermi Inst. Fermi National Accelerator Lab., Batavia, IL (United States))

    1992-01-01

    In these lectures I review the standard hot big-bang cosmology, emphasizing its successes, its shortcomings, and its major challenge-a detailed understanding of the formation of structure in the Universe. I then discuss the motivations for and the fundamentals of inflationary cosmology, particularly emphasizing the quantum origin of metric (density and gravity-wave) perturbations. Inflation addresses the shortcomings of the standard cosmology and provides the initial data'' for structure formation. I conclude by addressing the implications of inflation for structure formation, evaluating the various cold dark matter models in the light of the recent detection of temperature anisotropies in the cosmic background radiation by COBE. In the near term, the study of structure formation offers a powerful probe of inflation, as well as specific inflationary models.

  19. Inflation and Instability of a Polymeric Membrane

    DEFF Research Database (Denmark)

    Hassager, Ole; Kristensen, Susanne Brogaard; Larsen, Johannes Ruben

    1999-01-01

    We consider an axisymmetric polymeric membrane inflated by a uniform pressure difference acting across the membrane. The polymeric material is described by an arbitrary combination of a viscoelastic and a purely viscous component to the stress. Some viscoelastic materials described by a Mooney......-Rivlin model show a monotone increasing pressure during inflation of a spherical membrane. These materials develop a homogeneous membrane thickness in agreement with the Considere-Pearson condition. Molecularly based models such as the neo-Hookean, Doi-Edwards or Tom-Pom model show a pressure maximum when...... inflated. Membranes described by these models develop a local thinning of the membrane which may lead to bursting in finite time. (C) 1999 Elsevier Science B.V. All rights reserved....

  20. Large Field Inflation and Gravitational Entropy

    DEFF Research Database (Denmark)

    Kaloper, Nemanja; Kleban, Matthew; Lawrence, Albion

    2016-01-01

    Large field inflation can be sensitive to perturbative and nonperturbative quantum corrections that spoil slow roll. A large number $N$ of light species in the theory, which occur in many string constructions, can amplify these problems. One might even worry that in a de Sitter background, light...... species will lead to a violation of the covariant entropy bound at large $N$. If so, requiring the validity of the covariant entropy bound could limit the number of light species and their couplings, which in turn could severely constrain axion-driven inflation. Here we show that there is no such problem...... in this light, and show that they are perfectly consistent with the covariant entropy bound. Thus, while quantum gravity might yet spoil large field inflation, holographic considerations in the semiclassical theory do not obstruct it....

  1. Cosmic Microwave Background Polarization and Inflation

    Science.gov (United States)

    Chuss, David T.

    2011-01-01

    Measurements of the cosmic microwave background (CMB) offer a means to explore the universe at a very early epoch. Specifically, if the universe went through a brief period of exponential expansion called inflation as current data suggest, gravitational waves from this period would polarize the CMB in a specific pattern. At GSFC, we are currently working towards two experiments that work in concert to measure this polarization pattern in search of evidence for inflation. The Cosmology Large Angular Scale Surveyor (CLASS) will measure the polarization at frequencies between 40 and 150 GHz from the Atacama Desert in Chile. The Primordial Inflation Polarization Explorer (PIPER) is a balloon-borne experiment that will make similar measurements at frequencies between 200 and 600 GHz.

  2. Primordial two-component maximally symmetric inflation

    Science.gov (United States)

    Enqvist, K.; Nanopoulos, D. V.; Quirós, M.; Kounnas, C.

    1985-12-01

    We propose a two-component inflation model, based on maximally symmetric supergravity, where the scales of reheating and the inflation potential at the origin are decoupled. This is possible because of the second-order phase transition from SU(5) to SU(3)×SU(2)×U(1) that takes place when φ≅φcinflation at the global minimum, and leads to a reheating temperature TR≅(1015-1016) GeV. This makes it possible to generate baryon asymmetry in the conventional way without any conflict with experimental data on proton lifetime. The mass of the gravitinos is m3/2≅1012 GeV, thus avoiding the gravitino problem. Monopoles are diluted by residual inflation in the broken phase below the cosmological bounds if φcUSA.

  3. EUROZONE AND THE LOW INFLATION RISK

    Directory of Open Access Journals (Sweden)

    Bianca Steliana PÎRA (BEȘA

    2015-06-01

    Full Text Available The very low inflation in the Eurozone is, probably, the greatest challenge the European Central Bank has been handling since overcoming the 2008 crisis. This study analyses the monetary policies conducted by the ECB and their struggle to lift the inflation rate just below 2%. The paper presents the main causes for the actual situation, the countries where this problem is more persistent and the measures taken in order to raise inflation. It is of great interest to analyze whether the same policies are proper for different member states facing the deflation issue. For this reason, the study shows to what extent the single monetary policy represents an advantage or, on the contrary, a drawback for the Euro Area member states who try to overcome this critical situation

  4. Mass Inflation in the Loop Black Hole

    CERN Document Server

    Brown, Eric G; Modesto, Leonardo

    2011-01-01

    In classical general relativity the Cauchy horizon within a two-horizon black hole is unstable via a phenomenon known as mass inflation, in which the mass parameter (and the spacetime curvature) of the black hole diverges at the Cauchy horizon. Here we study this effect for loop black holes -- quantum gravitationally corrected black holes from loop quantum gravity -- whose construction alleviates the $r=0$ singularity present in their classical counterparts. We use a simplified model of mass inflation, which makes use of the generalized DTR relation, to conclude that the Cauchy horizon of loop black holes indeed results in a curvature singularity similar to that found in classical black holes. The DTR relation is of particular utility in the loop black hole because it does not directly rely upon Einstein's field equations. We elucidate some of the interesting and counterintuitive properties of the loop black hole, and corroborate our results using an alternate model of mass inflation due to Ori.

  5. Is inflation from unwinding fluxes IIB?

    Energy Technology Data Exchange (ETDEWEB)

    Gautason, Fridrik Freyr [Instituut voor Theoretische Fysica, K.University Leuven,Celestijnenlaan 200D, B-3001 Leuven (Belgium); Institut de Physique Théorique, Université Paris Saclay, CEA, CNRS,Orme des Merisiers, F-91191 Gif-sur-Yvette (France); Schillo, Marjorie; Riet, Thomas Van [Instituut voor Theoretische Fysica, K.University Leuven,Celestijnenlaan 200D, B-3001 Leuven (Belgium)

    2017-03-07

    In this paper we argue that the mechanism of unwinding inflation is naturally present in warped compactifications of type IIB string theory with local throats. The unwinding of flux is caused by its annihilation against branes. The resulting inflaton potential is linear with periodic modulations. We initiate an analysis of the inflationary dynamics and cosmological observables, which are highly constrained by moduli stabilization. For the simplified model of single-Kähler Calabi-Yau spaces we find that many, though not all of the consistency constraints can be satisfied. Particularly, in this simple model geometric constraints are in tension with obtaining the observed amplitude of the scalar power spectrum. However, we do find 60 efolds of inflation with a trans-Planckian field excursion which offers the hope that slightly more complicated models can lead to a fully consistent explicit construction of large field inflation of this kind.

  6. Quantum cosmological consistency condition for inflation

    Energy Technology Data Exchange (ETDEWEB)

    Calcagni, Gianluca [Instituto de Estructura de la Materia, CSIC, calle Serrano 121, 28006 Madrid (Spain); Kiefer, Claus [Institut für Theoretische Physik, Universität zu Köln, Zülpicher Strasse 77, 50937 Köln (Germany); Steinwachs, Christian F., E-mail: calcagni@iem.cfmac.csic.es, E-mail: kiefer@thp.uni-koeln.de, E-mail: christian.steinwachs@physik.uni-freiburg.de [Physikalisches Institut, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 3, 79104 Freiburg (Germany)

    2014-10-01

    We investigate the quantum cosmological tunneling scenario for inflationary models. Within a path-integral approach, we derive the corresponding tunneling probability distribution. A sharp peak in this distribution can be interpreted as the initial condition for inflation and therefore as a quantum cosmological prediction for its energy scale. This energy scale is also a genuine prediction of any inflationary model by itself, as the primordial gravitons generated during inflation leave their imprint in the B-polarization of the cosmic microwave background. In this way, one can derive a consistency condition for inflationary models that guarantees compatibility with a tunneling origin and can lead to a testable quantum cosmological prediction. The general method is demonstrated explicitly for the model of natural inflation.

  7. A dynamical weak scale from inflation

    Science.gov (United States)

    You, Tevong

    2017-09-01

    Dynamical scanning of the Higgs mass by an axion-like particle during inflation may provide a cosmological component to explaining part of the hierarchy problem. We propose a novel interplay of this cosmological relaxation mechanism with inflation, whereby the backreaction of the Higgs vacuum expectation value near the weak scale causes inflation to end. As Hubble drops, the relaxion's dissipative friction increases relative to Hubble and slows it down enough to be trapped by the barriers of its periodic potential. Such a scenario raises the natural cut-off of the theory up to ~ 1010 GeV, while maintaining a minimal relaxion sector without having to introduce additional scanning scalars or new physics coincidentally close to the weak scale.

  8. No-scale SUGRA SO(10) Inflation

    Science.gov (United States)

    Garg, Ila

    2017-10-01

    We show that a renormalizable theory based on gauge group SO(10) and Higgs system 10 \\oplus 210 \\oplus 126 \\oplus {\\overline{126}} with no scale supergravity can lead to a Starobinsky kind of potential for inflation. Successful inflation is possible in cases where the potential during inflation corresponds to SU(3)_C × SU(2)_{L} × SU(2)_{R} × U(1)_{B-L}, SU(5)× U(1) and flipped SU(5)× U(1) symmetries with suitable choice of superpotential parameters. The reheating in such a scenario can occur via non-perturbative decay of inflaton, i.e. through `preheating'. After the end of reheating, when Universe cools down, the finite-temperature potential can have a minimum which corresponds to MSSM.

  9. Avaliação do pico de pressão e da freqüência respiratória durante o uso de balão auto-inflável em um modelo de pulmão neonatal Evaluation of peak inspiratory pressure and respiratory rate during ventilation of an infant lung model with a self-inflating bag

    Directory of Open Access Journals (Sweden)

    Jefferson G. Resende

    2006-10-01

    Full Text Available OBJETIVO: Avaliar o pico de pressão inspiratória e a freqüência ventilatória obtidos por médicos quando da utilização de balão auto-inflável neonatal em modelo de pulmão. MÉTODOS: Quinze médicos ventilaram simuladores de pulmão de recém-nascidos a termo e pré-termo, sendo os desfechos captados através de um monitor de ventilação. RESULTADOS: As medianas dos picos de pressão foram 23 (intervalo interquartil, 15-47 e 26 (intervalo interquartil, 14-51 cmH2O, sendo menor que 20 em 41,2 e 35,8% das vezes; maior que 40 em 29,7 e 33,6% das vezes e entre 27 e 33 cmH2O em 8,2 e 6,5% das vezes, para o pulmão de termo e de pré-termo, respectivamente. As medianas das freqüências ventilatórias foram de 45 (intervalo interquartil, 36-57 e 48 (intervalo interquartil, 39-55,5 ciclos por minuto, sendo menor que 30 em 9,3 e 6,7% das vezes e maior que 60 em 12 e 13,3% das vezes, respectivamente, para o pulmão de termo e de pré-termo. As diferenças nas medianas não foram estatisticamente significantes. CONCLUSÃO: A ventilação utilizando o balão auto-inflável promoveu adequação para a freqüência ventilatória em aproximadamente 80% das vezes, e os médicos não conseguiram promover ventilação com mínima variabilidade na pressão, alcançando níveis diferentes daqueles definidos no curso de reanimação neonatal em 70% das vezes. Essa situação independeu da ventilação do pulmão-teste análogo ao sistema respiratório de recém-nascidos a termo ou pré-termo.OBJECTIVE: To evaluate the peak inspiratory pressure and ventilation rate achieved by physicians when using a neonatal self-inflating bag on a lung model. METHODS: Fifteen physicians ventilated full term and preterm infant lung simulators while the outcomes were captured by a ventilation monitor. RESULTS: Median peak pressures in cmH2O for full term and preterm lungs were 23 (interquartile range: 15-47 and 26 (interquartile range: 14-51, being less than 20 in 41.2 and

  10. Higgs inflation and the cosmological constant

    Energy Technology Data Exchange (ETDEWEB)

    Jegerlehner, Fred [Humboldt-Universitaet, Berlin (Germany). Inst. fuer Physik; Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2014-02-15

    The Higgs not only induces the masses of all SM particles, the Higgs, given its special mass value, is the natural candidate for the inflaton and in fact is ruling the evolution of the early universe, by providing the necessary dark energy which remains the dominant energy density. SM running couplings not only allow us to extrapolate SM physics up to the Planck scale, but equally important they are triggering the Higgs mechanism. This is possible by the fact that the bare mass term in the Higgs potential changes sign at about μ{sub 0}≅1.40 x 10{sup 16} GeV and in the symmetric phase is enhanced by quadratic terms in the Planck mass. Such a huge Higgs mass term is able to play a key role in triggering inflation in the early universe. In this article we extend our previous investigation by working out the details of a Higgs inflation scenario. We show how different terms contributing to the Higgs Lagrangian are affecting inflation. Given the SM and its extrapolation to scales μ>μ{sub 0} we find a calculable cosmological constant V(0) which is weakly scale dependent and actually remains large during inflation. This is different to the Higgs fluctuation field dependent ΔV(φ), which decays exponentially during inflation, and actually would not provide a sufficient amount of inflation. The fluctuation field has a different effective mass which shifts the bare Higgs transition point to a lower value μ'{sub 0} ≅7.7 x 10{sup 14} GeV. The vacuum energy V(0) being proportional to M{sub Pl}{sup 4} has a coefficient which vanishes near the Higgs transition point, such that the bare and the renormalized cosmological constant match at this point. The role of the Higgs in reheating and baryogenesis is emphasized.

  11. Sequential unilateral lung volume reduction for emphysema - Stretching the benefit.

    Science.gov (United States)

    Khorramnia, Sadie; Holsworth, Lynda; Mestitz, Hugh; Westall, Glen P; Williams, Trevor J; Gooi, Julian H; Snell, Gregory I

    2017-01-01

    Bronchoscopic Lung Volume Reduction (BLVR) and Surgical Lung Volume Reduction (SLVR) and are two different approaches used to remodel severely emphysematous lungs to improve lung function and quality-of-life. We present a case initially referred for lung transplantation, where sequential left upper lobe BLVR and 7 years later right upper lobe SLVR, providing enduring physiological and functional improvement. The potential for sustained benefit via sequential unilateral lung volume reduction is under-appreciated.

  12. Will quantum cosmology resurrect chaotic inflation model?

    CERN Document Server

    Kim, Sang Pyo

    2016-01-01

    The single field chaotic inflation model with a monomial power greater than one seems to be ruled out by the recent Planck and WMAP CMB data while Starobinsky model with a higher curvature term seems to be a viable model. Higher curvature terms being originated from quantum fluctuations, we revisit the quantum cosmology of the Wheeler-DeWitt equation for the chaotic inflation model. The semiclassical cosmology emerges from quantum cosmology with fluctuations of spacetimes and matter when the wave function is peaked around the semiclassical trajectory with quantum corrections a la the de Broglie-Bohm pilot theory.

  13. Constraints on Gauge Field Production during Inflation

    DEFF Research Database (Denmark)

    Nurmi, Sami; Sloth, Martin Snoager

    2014-01-01

    In order to gain new insights into the gauge field couplings in the early universe, we consider the constraints on gauge field production during inflation imposed by requiring that their effect on the CMB anisotropies are subdominant. In particular, we calculate systematically the bispectrum...... of the primordial curvature perturbation induced by the presence of vector gauge fields during inflation. Using a model independent parametrization in terms of magnetic non-linearity parameters, we calculate for the first time the contribution to the bispectrum from the cross correlation between the inflaton...

  14. Planck 2013 results. XXII. Constraints on inflation

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.

    2014-01-01

    We analyse the implications of the Planck data for cosmic inflation. The Planck nominal mission temperature anisotropy measurements, combined with the WMAP large-angle polarization, constrain the scalar spectral index to be ns = 0.9603 ± 0:0073, ruling out exact scale invariance at over 5 sigma...... power spectrum contains any features. We find that models with a parameterized oscillatory feature improve the fit by ΔΧ 2/eff ≈ 10; however, Bayesian evidence does not prefer these models. We constrain several single-field inflation models with generalized Lagrangians by combining power spectrum data...

  15. Inflation Dynamics and Real Marginal Costs

    DEFF Research Database (Denmark)

    Petrella, Ivan; Santoro, Emiliano

    2012-01-01

    This paper deals with the analysis of price-setting in U.S. manufacturing industries. Recent studies have heavily criticized the ability of the New Keynesian Phillips curve (NKPC) to fit aggregate inflation (see, e.g., Rudd and Whelan, 2006). We challenge this evidence, showing that forward......-looking behavior as implied by the New Keynesian model of price-setting is widely supported at the sectoral level. In fact, current and expected future values of the income share of intermediate goods emerge as an effective driver of inflation dynamics. Unlike alternative proxies for the forcing variable, the cost...

  16. Universal constraints on axions from inflation

    DEFF Research Database (Denmark)

    Ferreira, R. Z.; Sloth, M. S.

    2014-01-01

    through this mechanism, larger than the vacuum ones, without violating the observational constraints unless we combine this mechanism with a curvaton or if the sigma field becomes heavy and decays during inflation. Even in this last case there are non-trivial constraints coming from the slow......-roll evolution of the curvature perturbation on super horizon scales which should be taken into account. We also comment on implications for inflationary models where axions play an important role as, for example, models of natural inflation where more than one axion are included and models where the curvaton...

  17. Consistency relations in multi-field inflation

    Science.gov (United States)

    Gong, Jinn-Ouk; Seo, Min-Seok

    2018-02-01

    We study the consequences of spatial coordinate transformation in multi-field inflation. Among the spontaneously broken de Sitter isometries, only dilatation in the comoving gauge preserves the form of the metric and thus results in quantum-protected Slavnov-Taylor identities. We derive the corresponding consistency relations between correlation functions of cosmological perturbations in two different ways, by the connected and one-particle-irreducible Green's functions. The lowest-order consistency relations are explicitly given, and we find that even in multi-field inflation the consistency relations in the soft limit are independent of the detail of the matter sector.

  18. Path integral for multi-field inflation

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Jinn-Ouk [Asia Pacific Center for Theoretical Physics, Pohang 37673 (Korea, Republic of); Department of Physics, Postech, Pohang 37673 (Korea, Republic of); Seo, Min-Seok [Center for Theoretical Physics of the Universe, Institute for Basic Science, 34051 Daejeon (Korea, Republic of); Shiu, Gary [Department of Physics, University of Wisconsin-Madison, Madison, WI 53706 (United States); Department of Physics & Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay (Hong Kong)

    2016-07-20

    We develop the path integral formalism for studying cosmological perturbations in multi-field inflation, which is particularly well suited to study quantum theories with gauge symmetries such as diffeomorphism invariance. We formulate the gauge fixing conditions based on the Poisson brackets of the constraints, from which we derive two convenient gauges that are appropriate for multi-field inflation. We then adopt the in-in formalism to derive the most general expression for the power spectrum of the curvature perturbation including the corrections from the interactions of the curvature mode with other light degrees of freedom. We also discuss the contributions of the interactions to the bispectrum.

  19. Anisotropic inflation in Gauss-Bonnet gravity

    Energy Technology Data Exchange (ETDEWEB)

    Lahiri, Sayantani [ZARM, University of Bremen,Am Falltrum, 28359 Bremen (Germany)

    2016-09-19

    We study anisotropic inflation with Gauss-Bonnet correction in presence of a massless vector field. In this scenario, exact anisotropic power-law inflation is realized when the inflaton potential, gauge coupling function and the Gauss-Bonnet coupling are exponential functions. We show that anisotropy becomes proportional to two slow-roll parameters of the theory and hence gets enhanced in presence of quadratic curvature corrections. The stability analysis reveals that anisotropic power-law solutions remain stable over a substantially large parameter region.

  20. Reducing the spectral index in supernatural inflation

    Science.gov (United States)

    Lin, Chia-Min; Cheung, Kingman

    2009-04-01

    Supernatural inflation is an attractive model based on just a flat direction with soft supersymmetry breaking mass terms in the framework of supersymmetry. The beauty of the model is that it needs no fine-tuning. However, the prediction of the spectral index is ns≳1, in contrast to experimental data. In this paper, we discuss supernatural inflation with the spectral index reduced to ns=0.96 without any fine-tuning, considering the general feature that a flat direction is lifted by a nonrenormalizable term with an A-term.

  1. Money, Inflation and Growth Relationship: The Turkish Case

    National Research Council Canada - National Science Library

    Cuma Bozkurt

    2014-01-01

    .... While the course of the relationship between money supply and inflation is evident in general terms, an overall tendency related to the relationship between inflation and growth hasn't been clarified...

  2. Fiscal Deficits, Monetary Reform and Inflation Stabilization in Romania.

    NARCIS (Netherlands)

    van Wijnbergen, S.J.G.; Budina, N.

    2001-01-01

    Investigates the consistency between inflation, monetary reform and fiscal policy in Romania. Offers a framework for the assessment of the fiscal and monetary interactions of Romanian economy; Shows impact of inflation on fiscal inconsistency measure; Considers importance of consolidating public

  3. Verification and Validation of an Innovative Inflatable Structure Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An inflatable habitat is a pressure vessel with flexible shell. Notable features such as low weight, large inflated operational volume, and small pre-deployment...

  4. Lightweight Materials and Structures (LMS): Inflatable Structures Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Inflatable Structures (InSTAR) project goal is to demonstrate long term durability of inflatable habitat structures for potential utilization as either in-space...

  5. Verification and Validation of an Innovative Inflatable Structure Design Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An inflatable habitat is a pressure vessel with flexible shell. Notable features such as low weight, large inflated operational volume, and small pre-deployment...

  6. A perspective on the measurement of inflation credibility

    Directory of Open Access Journals (Sweden)

    J Rossouw

    2014-07-01

    Full Text Available Inflation targeting anchors inflation expectations, which are not within the sphere of control of the authorities, but can only be influenced over time by consistent policy.  As public distrust of inflation figures will feed through to inflation expectations, this paper highlights a comparison of the credibility of two different measures of inflation in terms of an inflation credibility barometer.  In a comparison of the barometer results to the analysis of inflation perceptions reported by other central banks, it is concluded that the barometer delivers superior results.  The main recommendation is that respondents should be requested in a follow-up study to indicate whether they attach a higher degree of credibility to the overall inflation rate or the rate used for targeting purposes.

  7. MEASURING INFLATION THROUGH STOCHASTIC APPROACH TO INDEX NUMBERS FOR PAKISTAN

    National Research Council Canada - National Science Library

    Zahid Asghar; Farhat Tahira

    2009-01-01

      This study attempts to estimate the rate of inflation in Pakistan through stochastic approach to index numbers which provides not only point estimate but also confidence interval for the rate of inflation...

  8. The role of unsteady effusion rates on inflation in long-lived lava flow fields

    Science.gov (United States)

    Rader, E.; Vanderkluysen, L.; Clarke, A.

    2017-11-01

    The emission of volcanic gases and particles can have global and lasting environmental effects, but their timing, tempo, and duration can be problematic to quantify for ancient eruptions where real-time measurements are absent. Lava flows, for example, may be long-lasting, and their impact is controlled by the rate, tempo, and vigor of effusion. These factors are currently difficult to derive from the geologic record but can have large implications for the atmospheric impact of an eruption. We conducted a set of analogue experiments on lava flow inflation aiming at connecting lava morphologies preserved in the rock record to eruption tempo and dynamics through pulsating effusion rates. Inflation, a process where molten material is injected beneath the crust of an active lava flow and lifts it upwards, is a common phenomenon in basaltic volcanic systems. This mechanism requires three components: a) a coherent, insulating crust; b) a wide-spread molten core; and c) pressure built up beneath the crust from a sustained supply of molten material. Inflation can result in a lava flow growing tens of meters thick, even in flow fields that expand hundreds of square kilometers. It has been documented that rapid effusion rates tend to create channels and tubes, isolating the active part of the flow from the stagnant part, while slow effusion rates may cause crust to form quickly and seize up, forcing lava to overtop the crust. However, the conditions that allow for inflation of large flow fields have not previously been evaluated in terms of effusion rate. By using PEG 600 wax and a programmable pump, we observe how, by pulsating effusion rate, inflation occurs even in very low viscosity basaltic eruptions. We show that observations from inflating Hawaiian lava flows correlate well with experimental data and indicate that instantaneous effusion rates may have been 3 times higher than average effusion rates during the emplacement of the 23 January 1988 flow at Kīlauea (Hawai

  9. Low Inflation, Deflation, and Policies for Future Price Stability

    OpenAIRE

    Taylor, John-B

    2001-01-01

    The effects of three different inflationary environments--high inflation, low inflation, and negative inflation--on real output stability are examined by looking at the experiences of Japan and the United States during the last 30 years. I begin by going back to see how things looked from the vantage point of the 1987 international conference at the Bank of Japan. Next I trace out how economic performance has evolved since then. Economic performance appears to have been better with low inflat...

  10. Inflation Experiences in Latin America, 2007-2008

    OpenAIRE

    Mark Weisbrot; David Rosnick

    2009-01-01

    This paper looks briefly at the recent inflation experiences of ten Latin American countries: Brazil, Mexico, Venezuela, Colombia, Chile, Peru, Ecuador, Guatemala, the Dominican Republic, and Bolivia. The authors construct a core inflation index (excluding food and energy), and look at three-month changes in both headline and core inflation. The paper focuses on the increase in inflation from April 2007 to July 2008, driven by a surge in food and energy prices worldwide. These prices have sin...

  11. Various Measures of Underlying Inflation in Poland 1995 - 98

    OpenAIRE

    Przemyslaw Wozniak

    1999-01-01

    As inflation targeting gains popularity policy makers, monetary authorities seek to design a measure of inflation that would be a good indicator of fundamental demand-driven price movements, i.e. the underlying or core rate of inflation. It is widely acknowledged that the Consumer Price Index (which is the simple weighted average of price changes of the set of goods and services comprising the consumers' expenditure basket) is a rather deficient indicator of the 'trend' inflation as it is hig...

  12. 77 FR 76406 - Criteria and Procedures for Proposed Assessment of Civil Penalties; Inflation Adjustment

    Science.gov (United States)

    2012-12-28

    ...; Inflation Adjustment AGENCY: Mine Safety and Health Administration, Labor. ACTION: Final rule. SUMMARY: The... for inflation. The Federal Civil Penalties Inflation Adjustment Act of 1990, (Inflation Adjustment Act... penalties for inflation at least once every four years according to the formula specified in the Inflation...

  13. 77 FR 64431 - Civil Monetary Penalty Inflation Adjustment Rule

    Science.gov (United States)

    2012-10-22

    ... Surface Transportation Board 49 CFR Part 1022 Civil Monetary Penalty Inflation Adjustment Rule AGENCY... issuing a final rule to adjust the Board's civil monetary penalties for inflation on a periodic basis pursuant to the Federal Civil Penalties Inflation Act of 1990, as amended by the Debt Collection...

  14. 78 FR 4057 - Inflation Adjustment of Civil Money Penalty Amounts

    Science.gov (United States)

    2013-01-18

    ... URBAN DEVELOPMENT 24 CFR Parts 28, 30, and 180 RIN 2501-AD59 Inflation Adjustment of Civil Money Penalty... civil money penalty and civil penalty regulations by making inflation adjustments that are required by the Federal Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note) (FCPIA Act). The...

  15. 78 FR 66643 - Civil Monetary Penalty Inflation Adjustment Rule

    Science.gov (United States)

    2013-11-06

    ... AGENCY 40 CFR Part 19 RIN 2020-AA49 Civil Monetary Penalty Inflation Adjustment Rule AGENCY... final rule that amends the Civil Monetary Penalty Inflation Adjustment Rule. This action is mandated by the Debt Collection Improvement Act of 1996 (DCIA) to adjust for inflation certain statutory civil...

  16. 77 FR 72915 - Civil Monetary Penalties; Adjustment for Inflation

    Science.gov (United States)

    2012-12-07

    ... Office of the Secretary 15 CFR Part 6 RIN 0605-AA31 Civil Monetary Penalties; Adjustment for Inflation... Commerce (the Department). The Federal Civil Penalties Inflation Adjustment Act of 1990, as amended by the... penalties (CMP) for inflation no later than October 23, 1996, and requires agencies to make adjustments at...

  17. 76 FR 74720 - Inflation Adjustment of Civil Monetary Penalties; Correction

    Science.gov (United States)

    2011-12-01

    ... 46 CFR Part 506 RIN 3072-AC36 Inflation Adjustment of Civil Monetary Penalties; Correction AGENCY..., 2009 (74 FR 38114). The rule adjusts for inflation the maximum amount of each statutory civil penalty... Civil Penalties Inflation Adjustment Act of 1990, as amended by the Debt Collection Improvement Act of...

  18. Inflation protection from home-ownership : Long-run evidence

    NARCIS (Netherlands)

    Brounen, Dirk; Eichholtz, P.; Staetmans, S.; Theebe, Marcel

    2014-01-01

    This article examines the inflation hedging capacity of the private home. We employ unique long-term data for inflation, house price dynamics and rents for Amsterdam dating back to 1814, allowing us to study total housing returns in different inflation regimes and for varying investment horizons.

  19. Effects of user experience and method in the inflation of ...

    African Journals Online (AJOL)

    Context: Endotracheal tube cuff pressure (ETCP) is recommended to be maintained between 20.30 cmH2O limits. While insufficient inflation of ETC may cause aspirations, over.inflation of it may lead to damage in tracheal epithelium. Aims: We planned to investigate the effects of user experience and cuff pressure inflation ...

  20. 78 FR 56868 - Adjustment of Indemnification for Inflation

    Science.gov (United States)

    2013-09-16

    ... Adjustment of Indemnification for Inflation AGENCY: Office of General Counsel, U.S Department of Energy... requires an inflation adjustment of the indemnification amount at least once during each 5- year period...) . This notice announces $12,697,798,000 as the second inflation-adjusted amount based on the aggregate...

  1. 32 CFR 269.3 - Civil monetary penalty inflation adjustment.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Civil monetary penalty inflation adjustment. 269... DEFENSE (CONTINUED) MISCELLANEOUS CIVIL MONETARY PENALTY INFLATION ADJUSTMENT § 269.3 Civil monetary penalty inflation adjustment. The Department shall, not later than 180 days after the enactment of the...

  2. What Is Wrong with Grade Inflation (If Anything)?

    Science.gov (United States)

    Finefter-Rosenbluh, Ilana; Levinson, Meira

    2015-01-01

    Grade inflation is a global phenomenon that has garnered widespread condemnation among educators, researchers, and the public. Yet, few have deliberated over the ethics of grading, let alone the ethics of grade inflation. The purpose of this paper is to map out and examine the ethics of grade inflation. By way of beginning, we clarify why grade…

  3. 76 FR 74625 - Civil Monetary Penalties Inflation Adjustment

    Science.gov (United States)

    2011-12-01

    ...-AA69 Civil Monetary Penalties Inflation Adjustment AGENCIES: U.S. Customs and Border Protection... for inflation certain civil monetary penalties assessed under the Immigration and Nationality Act (INA... assessed under the INA. The Federal Civil Penalties Inflation Adjustment Act of 1990 (Adjustment Act...

  4. 77 FR 60047 - Adjustment of Civil Monetary Penalties for Inflation

    Science.gov (United States)

    2012-10-02

    ... CFR Part 36 RIN 1801-AA12 Adjustment of Civil Monetary Penalties for Inflation AGENCY: Department of... regulations to adjust the Department's civil monetary penalties (CMPs) for inflation, as required by the Federal Civil Penalties Inflation Adjustment Act of 1990. DATES: These regulations are effective October 2...

  5. 8 CFR 280.53 - Civil monetary penalties inflation adjustment.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Civil monetary penalties inflation... REGULATIONS IMPOSITION AND COLLECTION OF FINES § 280.53 Civil monetary penalties inflation adjustment. (a) In general. In accordance with the requirements of the Federal Civil Penalties Inflation Adjustment Act of...

  6. 78 FR 44419 - Civil Monetary Penalties Inflation Adjustments

    Science.gov (United States)

    2013-07-24

    ... Monetary Penalties Inflation Adjustments AGENCY: Federal Election Commission. ACTION: Final rules. SUMMARY: In accordance with the Federal Civil Penalties Inflation Adjustment Act of 1990, as amended, the Federal Election Commission is adopting final rules to apply inflation adjustments to certain civil...

  7. 78 FR 63465 - Adjusting Civil Money Penalties for Inflation

    Science.gov (United States)

    2013-10-24

    ... CORPORATION Adjusting Civil Money Penalties for Inflation AGENCY: Farm Credit System Insurance Corporation... Act of 1971, as amended. The Federal Civil Penalties Inflation Adjustment Act of 1990, as amended by... impose CMPs to regularly evaluate those CMPs and to adjust them periodically for inflation, so they...

  8. Inflation of polymer melts into elliptic and circular cylinders

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz; Christensen, Jens Horslund; Gøttsche, Søren

    2000-01-01

    of the inflating membrane is detected by fibreoptic sensors positioned in the cylinder. The pressure difference across the inflating membrane is measured as well. Measurements were performed on a polyisobutylene melt. As the deformation in this device is highly non-uniform, the response of the material is modelled...... simulations and experimental measurements of the membrane inflation....

  9. 10 CFR 765.12 - Inflation index adjustment procedures.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Inflation index adjustment procedures. 765.12 Section 765... THORIUM PROCESSING SITES Reimbursement Criteria § 765.12 Inflation index adjustment procedures. (a) The... § 765.2(i) of this rule) shall be adjusted for inflation as provided by this section. (b) To make...

  10. 76 FR 47177 - Publication of Housing Price Inflation Adjustment

    Science.gov (United States)

    2011-08-04

    ... of the Secretary Publication of Housing Price Inflation Adjustment AGENCY: Office of the Under.... The law requires the Department of Defense to adjust this amount annually to reflect inflation and to publish the new amount in the Federal Register. We have applied the inflation index required by the...

  11. 8 CFR 1280.53 - Civil monetary penalties inflation adjustment.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Civil monetary penalties inflation... penalties inflation adjustment. (a) In general. In accordance with the requirements of the Federal Civil Penalties Inflation Adjustment Act of 1990, Pub. L. 101-410, 104 Stat. 890, as amended by the Debt...

  12. Inflation - Growth nexus in Ethiopia: Evidence from Threshold Auto ...

    African Journals Online (AJOL)

    Achieving high economic growth with stable and low inflation level has long been the macroeconomic policy objective of Ethiopia. The Ethiopian economy, however, has gone through different paths of inflation and growth relationship over the last four decades. Before 2003, Ethiopia was well-known as a low inflation ...

  13. Inflation and Economic Growth: An Estimate of the Threshold Level ...

    African Journals Online (AJOL)

    This study investigated the relationship between inflation and economic growth in Nigeria, from 1970 to 2009. It adapted the Khan and Sendhadji's (2001) threshold regression technique to examine the existence of optimal inflation. The Granger causality test was utilised to test the causal relationship between inflation and ...

  14. Portfolio Management with Stochastic Interest Rates and Inflation Ambiguity

    DEFF Research Database (Denmark)

    Munk, Claus; Rubtsov, Alexey Vladimirovich

    2014-01-01

    We solve, in closed form, a stock-bond-cash portfolio problem of a risk- and ambiguity-averse investor when interest rates and the inflation rate are stochastic. The expected inflation rate is unobservable, but the investor can learn about it from observing realized inflation and stock and bond...

  15. Venezuela's Economic Recovery: Is It Sustainable?

    OpenAIRE

    Jake Johnston; Mark Weisbrot

    2012-01-01

    Venezuela’s current growth is generally described as unsustainable, with various negative scenarios put forth, including spiraling debt, inflation, and balance of payments crises. However, these pessimistic forecasts have been far off the mark for most of the past decade. This paper looks at the available economic data to see if Venezuela’s economic recovery could be sustained, or even accelerated. It finds that Venezuela’s current economic growth is sustainable and could continue at the curr...

  16. Can Ambu self-inflating bag and Neopuff infant resuscitator provide adequate and safe manual inflations for infants up to 10 kg weight?

    Science.gov (United States)

    Tracy, Mark; Maheshwari, Rajesh; Shah, Dharmesh; Hinder, Murray

    2017-07-01

    Manual resuscitation devices for infants and newborns must be able to provide adequate ventilation in a safe and consistent manner across a wide range of patient sizes (0.5-10 kg) and differing clinical states. There are little comparative data assessing biomechanical performance of common infant manual resuscitation devices across the manufacturers' recommended operating weight ranges. We aimed to compare performance of the Ambu self-inflating bag (SIB) with the Neopuff T-piece resuscitator in three resuscitation models. Five experienced clinicians delivered targeted ventilation to three lung models differing in compliance, delivery pressures and inflation rates; Preterm (0.5 mL/cmH2O, 25/5 cmH2O, 60 per minute), Term (3 mL/cmH2O, 30/5 cmH2O, 40 per minute) and Infant (9 mL/cmH2O, 35/5 cmH2O, 30 per minute). The Neopuff was examined with three gas inflow rates (5 litres per minute (LPM), 10 LPM and 15 LPM) and the Ambu with no gas inflow. 3309 inflations were collected and analysed with analysis of variance for repeated measures. The Neopuff was unable to reach set peak inflation pressures and exhibited seriously elevated positive end expiratory pressure (PEEP) with all inflow gas rates (p<0.001) in this infant model. The Ambu SIB accurately delivered targeted pressures in all three models. The Ambu SIB was able to accurately deliver targeted pressures across all three models from preterm to infant. The Neopuff infant resuscitator was unable to deliver the targeted pressures in the infant model developing clinically significant levels of inadvertent PEEP which may pose risk during infant resuscitation. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  17. The relationship between inflation and inflation uncertainty. Empirical evidence for the newest EU countries.

    Science.gov (United States)

    Viorica, Daniela; Jemna, Danut; Pintilescu, Carmen; Asandului, Mircea

    2014-01-01

    The objective of this paper is to verify the hypotheses presented in the literature on the causal relationship between inflation and its uncertainty, for the newest EU countries. To ensure the robustness of the results, in the study four models for inflation uncertainty are estimated in parallel: ARCH (1), GARCH (1,1), EGARCH (1,1,1) and PARCH (1,1,1). The Granger method is used to test the causality between two variables. The working hypothesis is that groups of countries with a similar political and economic background in 1990 and are likely to be characterized by the same causal relationship between inflation and inflation uncertainty. Empirical results partially confirm this hypothesis. C22, E31, E37.

  18. Toward pole inflation and attractors in supergravity: Chiral matter field inflation

    Science.gov (United States)

    Kobayashi, T.; Seto, O.; Tatsuishi, T. H.

    2017-12-01

    In string-inspired supergravity theory, the Kähler metric of chiral matter fields often has a pole. Such a Kähler metric is interesting from the viewpoint of the framework of the pole inflation, where the scalar potential can be stretched out to be flat around the pole for a canonically normalized field and inflation can be realized. However, when the Kähler metric has a pole, the scalar potential can also have a pole at the same point in supergravity theory. We study such supergravity models with a pole, and provide numerical analysis of inflationary dynamics and resultant density perturbation. In contrast with the usual pole inflation models, inflation in this supergravity-based model occurs not on the pole but in a region apart from the pole. We show that the existence of the pole in the scalar potential is crucial nevertheless. We also examine attractor behavior of our model.

  19. Pension systems, intergenerational risk sharing and inflation

    NARCIS (Netherlands)

    Beetsma, R.M.W.J.; Bovenberg, A.L.

    2006-01-01

    We investigate intergenerational risk sharing in two-pillar pension systems with a pay-as-you-go pillar and a funded pillar. We consider shocks in productivity, depreciation of capital and inflation. The funded pension pillar can be either defined contribution or defined benefit, with benefits

  20. Inflation in a viscous fluid model

    Energy Technology Data Exchange (ETDEWEB)

    Bamba, Kazuharu [Fukushima University, Division of Human Support System, Faculty of Symbiotic Systems Science, Fukushima (Japan); Odintsov, Sergei D. [Campus UAB, Carrer de Can Magrans, Institut de Ciencies de lEspai (IEEC-CSIC), Barcelona (Spain); Passeig Lluis Companys, Institucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona (Spain)

    2016-01-15

    We explore a fluid description of the inflationary universe. In particular, we investigate a fluid model in which the equation of state (EoS) for a fluid includes bulk viscosity. We find that the three observables of inflationary cosmology, i.e., the spectral index of the curvature perturbations, the tensor-to-scalar ratio of the density perturbations, and the running of the spectral index, can be consistent with the recent Planck results. We also reconstruct the explicit EoS for a fluid from the spectral index of the curvature perturbations compatible with the Planck analysis. In the reconstructed models of a fluid, the tensor-to-scalar ratio of the density perturbations can satisfy the constraints obtained from the Planck satellite. The running of the spectral index can explain the Planck data. In addition, it is demonstrated that in the reconstructed models of a fluid, the graceful exit from inflation can be realized. Moreover, we show that the singular inflation can occur in a fluid model. Furthermore, we show that a fluid description of inflation can be equivalent to the description of inflation in terms of scalar field theories. (orig.)

  1. Central bank independence and inflation revisited

    NARCIS (Netherlands)

    Klomp, J.G.; Haan, de J.

    2010-01-01

    We re-examine the relationship between central bank independence (CBI), proxied by the central bank governor's turnover rate and an indicator based on central bank laws in place, and inflation using a random coefficient model with the Hildreth-Houck estimator for more than 100 countries in the

  2. Central bank independence and inflation revisited

    NARCIS (Netherlands)

    Klomp, Jeroen; de Haan, Jakob

    We re-examine the relationship between central bank independence (CBI), proxied by the central bank governor's turnover rate and an indicator based on central bank laws in place, and inflation using a random coefficient model with the Hildreth-Houck estimator for more than 100 countries in the

  3. Inflation Rates, Car Devaluation, and Chemical Kinetics.

    Science.gov (United States)

    Pogliani, Lionello; Berberan-Santos, Mario N.

    1996-01-01

    Describes the inflation rate problem and offers an interesting analogy with chemical kinetics. Presents and solves the car devaluation problem as a normal chemical kinetic problem where the order of the rate law and the value of the rate constant are derived. (JRH)

  4. Inflation - Adjusted Accounting and Corporate Value Redefinition ...

    African Journals Online (AJOL)

    In many countries, including Nigeria, the historical concept is adopted in the recording of financial transactions. Convenient as this approach suggests, in times of generally rising prices, the purchasing power eroding effect of inflation is over-looked. This ought not to be so, considering the tendency to speculate ...

  5. STOCHASTIC MODELING OF INFLATION IN NIGERIA

    African Journals Online (AJOL)

    2006-04-04

    Apr 4, 2006 ... In this paper, we adopt a time series approach in modeling inflation in Nig'eria using a four-decade data (1960- 1999) on consumer price index.. Logarithmic transformation was used to stabilize the variation in the data. On the whole four decades, a quadratic trend was obtained. This is also true with the ...

  6. Based Micro Business Organisations: A Strategic Inflation ...

    African Journals Online (AJOL)

    There are several perspectives of micro business management, which if strategically redefined and reinvented, could make a difference in the advancement of this crucial constituency of the Nigeria economy. One of such concerns is project analysis and management, particularly in periods of high inflation. This study was ...

  7. Revisiting CMB constraints on warm inflation

    Science.gov (United States)

    Arya, Richa; Dasgupta, Arnab; Goswami, Gaurav; Prasad, Jayanti; Rangarajan, Raghavan

    2018-02-01

    We revisit the constraints that Planck 2015 temperature, polarization and lensing data impose on the parameters of warm inflation. To this end, we study warm inflation driven by a single scalar field with a quartic self interaction potential in the weak dissipative regime. We analyse the effect of the parameters of warm inflation, namely, the inflaton self coupling λ and the inflaton dissipation parameter QP on the CMB angular power spectrum. We constrain λ and QP for 50 and 60 number of e-foldings with the full Planck 2015 data (TT, TE, EE + lowP and lensing) by performing a Markov-Chain Monte Carlo analysis using the publicly available code CosmoMC and obtain the joint as well as marginalized distributions of those parameters. We present our results in the form of mean and 68 % confidence limits on the parameters and also highlight the degeneracy between λ and QP in our analysis. From this analysis we show how warm inflation parameters can be well constrained using the Planck 2015 data.

  8. The Impact of Inflation on Endowment Assets

    Science.gov (United States)

    Birkeland, Kathryn; Carr, David L.; Lavin, Angeline M.

    2013-01-01

    Maintaining spending power in real terms (current) while preserving an endowment's value in real terms (future) is the crux of intergenerational equity. Tobin's (1974) model provides the conceptual basis on which simulations were developed to study the impact of various inflation (0%, TIPS, CPI, HECA, and HEPI) and new giving scenarios ($0, $4…

  9. Primordial tensor modes from quantum corrected inflation

    DEFF Research Database (Denmark)

    Joergensen, Jakob; Sannino, Francesco; Svendsen, Ole

    2014-01-01

    We analyze quantum corrections on the naive $\\phi^4$-Inflation. These typically lead to an inflaton potential which carries a non-integer power of the field. We consider both minimal and non-minimal couplings to gravity. For the latter case we also study unitarity of inflaton-inflaton scattering...

  10. Characterization of polymers by bubble inflation

    DEFF Research Database (Denmark)

    Christensen, Jens Horslund; Rasmussen, Henrik K.; Kjær, Erik Michael

    1999-01-01

    In order to characterise materials using a simple and relative inexpensive method, the bubble inflation technique was modified. A polymer plate is clamped between a Teflon coated heating plate and a heated cylinder. By applying air through the heating plate the polymer membrane deforms into the c......In order to characterise materials using a simple and relative inexpensive method, the bubble inflation technique was modified. A polymer plate is clamped between a Teflon coated heating plate and a heated cylinder. By applying air through the heating plate the polymer membrane deforms...... into the cylinder. The top position of the membrane is monitored by fibreoptic sensors positioned in the cylinder. The pressure difference across the membrane is measured as well. The deformation in this inflation device is nonuniform and is only equal biaxial in the top of the deformed membrane. Due to this......, the response is modelled using a finite element method in 3D Cartesian coordinates. The K-BKZ constitutive equation is used to model the nonlinear properties of the material. Using linear viscoelastic properties from oscillatory shear measurements and measurements of the bubble inflation, estimation...

  11. Stability of inflation processes with polymer melts

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz; Eriksson, Torbjörn Gerhard; Hassager, Ole

    2002-01-01

    is performed applying a gas pressure into the core of the cylinder, which press the molten plastic cylinder outward. During the inflation the plastic may burst. The occurrence of this burst, or break, puts a limit on the possibility to produce a specified product at some, or all, processing conditions. Here...

  12. Understanding Inflation and Revising National Price Data

    International Development Research Centre (IDRC) Digital Library (Canada)

    Pete

    Abstract: Lebanon is a small dependent economy with extreme vulnerability to external price shocks; yet no inflation targeting policy or good knowledge on price evolutions is available. The quality of statistics is hampered by severe technical problems as well as an acute shortage of human and material resources.

  13. Experimental evidence on inflation expectation formation

    NARCIS (Netherlands)

    Pfajfar, D.; Zakelj, B.

    Using laboratory experiments within a New Keynesian sticky price framework, we study the process of inflation expectation formation. We focus on adaptive learning and rational expectations contrary to the previous literature that mostly studied simple heuristics. Using a test for rational

  14. Interrelationships among unemployment, inflation and economic ...

    African Journals Online (AJOL)

    The recommendations of the paper include greater but cautious integration of Nigeria's economy with the global market; tight money policy to control broad money growth and hence, inflation; infrastructural development, improvement in security and favourable tax regimes to enhance the attractiveness of the economy to ...

  15. Inflatable habitation for the lunar base

    Science.gov (United States)

    Roberts, M.

    1992-01-01

    Inflatable structures have a number of advantages over rigid modules in providing habitation at a lunar base. Some of these advantages are packaging efficiency, convenience of expansion, flexibility, and psychological benefit to the inhabitants. The relatively small, rigid cylinders fitted to the payload compartment of a launch vehicle are not as efficient volumetrically as a collapsible structure that fits into the same space when packaged, but when deployed is much larger. Pressurized volume is a valuable resource. By providing that resource efficiently, in large units, labor intensive external expansion (such as adding additional modules to the existing base) can be minimized. The expansive interior in an inflatable would facilitate rearrangement of the interior to suite the evolving needs of the base. This large, continuous volume would also relieve claustrophobia, enhancing habitability and improving morale. The purpose of this paper is to explore some of the aspects of inflatable habitat design, including structural, architectural, and environmental considerations. As a specific case, the conceptual design of an inflatable lunar habitat, developed for the Lunar Base Systems Study at the Johnson Space Center, is described.

  16. Design and Analysis Methodologies for Inflated Beams

    NARCIS (Netherlands)

    Veldman, S.L.

    2005-01-01

    The central theme of the thesis is bending behaviour of inflated beams. Three different types of beams have been analysed for the bending load case: a straight cylindrical beam made of anisotropic foil material, a conical beam made of an isotropic foil material, and a carbon fibre braided beam. The

  17. The structural characteristics of inflatable beams

    Science.gov (United States)

    Wicker, William J.

    The use of pneumatic architecture has historically been limited because of its poor performance in the areas of strength and rigidity. Yet the advent of new high strength fibers such as Allied Signal's "Spectra 1000" composed of ultra-high molecular weight polyethylene offer hope for the expanded use of inflatable structures. This thesis involved the design, construction and stiffness testing of two inflatable beams fashioned from Spectra cloth. The test data and calculations indicated that the prototype tubes were neither as strong or stiff as rigid composite or metal alloy tubes. The tubes did, however, show an improvement over the capabilities of conventional inflatable tubes fashioned from nylon or dacron fabrics. The data from the deflection tests offered insight on the non-linear and anisotropic behavior of fabrics. The data interpretation process was quite educational for the author, for he learned that nearly every assumption he held and theory postulated concerning the behavior of fabric beams - based on his knowledge of isotropic materials - varied from somewhat to quite inaccurate. This project has increased the author's interest in inflatable structures and has highlighted the importance of understanding the behavior of textiles for effective design efforts.

  18. Higgs-otic inflation and moduli stabilization

    Energy Technology Data Exchange (ETDEWEB)

    Bielleman, Sjoerd; Ibáñez, Luis E.; Pedro, Francisco G. [Departamento de Física Teórica and Instituto de Física Teórica UAM/CSIC,Universidad Autónoma de Madrid,Cantoblanco, 28049 Madrid (Spain); Valenzuela, Irene [Max-Planck-Institut fur Physik,Föhringer Ring 6, 80805 Munich (Germany); Institute for Theoretical Physics and Center for Extreme Matter and Emergent Phenomena, Utrecht University,Leuvenlaan 4, 3584 CE Utrecht (Netherlands); Wieck, Clemens [Departamento de Física Teórica and Instituto de Física Teórica UAM/CSIC,Universidad Autónoma de Madrid,Cantoblanco, 28049 Madrid (Spain)

    2017-02-14

    We study closed-string moduli stabilization in Higgs-otic inflation in Type IIB orientifold backgrounds with fluxes. In this setup large-field inflation is driven by the vacuum energy of mobile D7-branes. Imaginary selfdual (ISD) three-form fluxes in the background source a μ-term and the necessary monodromy for large field excursions while imaginary anti-selfdual (IASD) three-form fluxes are sourced by non-perturbative contributions to the superpotential necessary for moduli stabilization. We analyze Kähler moduli stabilization and backreaction on the inflaton potential in detail. Confirming results in the recent literature, we find that integrating out heavy Kähler moduli leads to a controlled flattening of the inflaton potential. We quantify the flux tuning necessary for stability even during large-field inflation. Moreover, we study the backreaction of supersymmetrically stabilized complex structure moduli and the axio-dilaton in the Kähler metric of the inflaton. Contrary to previous findings, this backreaction can be pushed far out in field space if a similar flux tuning as in the Kähler sector is possible. This allows for a trans-Planckian field range large enough to support inflation.

  19. Grade Inflation in UK Higher Education

    Science.gov (United States)

    Bachan, Ray

    2017-01-01

    This paper examines the continual increase in the proportion of "good" honour degrees awarded by UK universities since the mid-2000s. This trend has brought with it the charge of "grade inflation" that may reflect falling standards in UK higher education. This issue has been raised in the national press and in government which…

  20. Brane-world cosmology and inflation

    Indian Academy of Sciences (India)

    This brane-world scenario is quite attractive because of the non-trivial geometry in the bulk and because it successfully gives four-dimensional general relativity in the low energy limit. After reviewing basic features of the RS2 scenario, we consider a brane-world inflation model driven by the dynamics of a scalar field living ...

  1. Forecasting Inflation through Econometrics Models: An Empirical ...

    African Journals Online (AJOL)

    This article aims at modeling and forecasting inflation in Pakistan. For this purpose a number of econometric approaches are implemented and their results are compared. In ARIMA models, adding additional lags for p and/or q necessarily reduced the sum of squares of the estimated residuals. When a model is estimated ...

  2. Inflazione da "Oil Push"? (Oil push inflation?

    Directory of Open Access Journals (Sweden)

    M. PARKIN

    2013-12-01

    Full Text Available Il presente lavoro indaga la visione " oilpush " dell'inflazione  , la linea ict di ragionamento e le sue conclusioni esaminando l'evoluzione dell'inflazione e variabili correlate in sei paesi , nel periodo 1968-1978 . L'articolo è principalmente  empirico , con proposte di standard di macroeconomia e teorie qui monetaria sono sullo sfondo . L'ipotesi di Oil push  viene prima esaminata e giudicata essere privo diefficacia  empirica . Le politiche monetarie degli ultimi dieci anni sono esaminate e riscontrate  per spiegare l' evoluzione dell'inflazione . Infine sono brevemente esaminati i costi della riduzione dei tassi di inflazione nel periodo post - 1973 .The present work investigates the “oilpush” view of inflation, its line of reasoning and its conclusions, by examining the evolution of inflation and related variables in six countries, over the period 1968-1978. The paper is mainly empirical, using standard propositions from macroeconomics and monetary theory which are in the background, however, rather than the forefront. The oil push hypothesis is first examined and found to be lacking in empirical content. The monetary policies of the last decade are then reviewed and found to account well for the evolution of inflation. Finally, the costs of the reduction of inflations in the post-1973 period are briefly examined. JEL: E31

  3. Grade Inflation and Law School Admissions

    Science.gov (United States)

    Wongsurawat, Winai

    2008-01-01

    Purpose: The purpose of this paper is to evaluate the evidence on whether grade inflation has led to an increasing emphasis on standardized test scores as a criterion for law school admissions. Design/methodology/approach: Fit probabilistic models to admissions data for American law schools during the mid to late 1990s, a period during which…

  4. Financial Results during Periods of Inflation.

    Science.gov (United States)

    Thompson, James W.; Anderson, Richard E.

    1983-01-01

    The effects of inflation on the operations of 10 northeastern colleges and universities and the effect of using current cost accounting are considered. The focus is on adjustments to assets in the plant fund by restating the surplus and deficit calculations of four state and six private institutions. The 10 institutions had plant assets with an…

  5. The Hubble Flow of Plateau Inflation

    NARCIS (Netherlands)

    Coone, Dries; Roest, Diederik; Vennin, Vincent

    2015-01-01

    In the absence of CMB precision measurements, a Taylor expansion has often been invoked to parametrize the Hubble flow function during inflation. The standard "horizon flow" procedure implicitly relies on this assumption. However, the recent Planck results indicate a strong preference for plateau

  6. Constraints on single-field inflation

    Energy Technology Data Exchange (ETDEWEB)

    Pirtskhalava, David [Institut de Théorie des Phénoménes Physiques,EPFL Lausanne (Switzerland); Santoni, Luca; Trincherini, Enrico [Scuola Normale Superiore,Piazza dei Cavalieri 7, 56126, Pisa (Italy); INFN - Sezione di Pisa,56200, Pisa (Italy)

    2016-06-28

    Many alternatives to canonical slow-roll inflation have been proposed over the years, one of the main motivations being to have a model, capable of generating observable values of non-Gaussianity. In this work, we (re-)explore the physical implications of a great majority of such models within a single, effective field theory framework (including novel models with large non-Gaussianity discussed for the first time below). The constraints we apply — both theoretical and experimental — are found to be rather robust, determined to a great extent by just three parameters: the coefficients of the quadratic EFT operators (δN){sup 2} and δNδE, and the slow-roll parameter ε. This allows to significantly limit the majority of single-field alternatives to canonical slow-roll inflation. While the existing data still leaves some room for most of the considered models, the situation would change dramatically if the current upper limit on the tensor-to-scalar ratio decreased down to r<10{sup −2}. Apart from inflationary models driven by plateau-like potentials, the single-field model that would have a chance of surviving this bound is the recently proposed slow-roll inflation with weakly-broken galileon symmetry. In contrast to canonical slow-roll inflation, the latter model can support r<10{sup −2} even if driven by a convex potential, as well as generate observable values for the amplitude of non-Gaussianity.

  7. Diagnostic Inflation Causes and a Suggested Cure

    NARCIS (Netherlands)

    Batstra, Laura; Frances, Allen

    There have been a striking diagnostic inflation and a corresponding increase in the use of psychotropic drugs during the past 30 years. DSM-5, scheduled to appear in May 2013, proposes another grand expansion of mental illness. In this article, we will review the causes of diagnostic exuberance and

  8. Optimization of stent implantation using a high pressure inflation protocol.

    Science.gov (United States)

    Vallurupalli, Srikanth; Bahia, Amit; Ruiz-Rodriguez, Ernesto; Ahmed, Zubair; Hakeem, Abdul; Uretsky, Barry F

    2016-01-01

    High-pressure inflation is the universal standard for stent deployment but a specific protocol for its use is lacking. We developed a standardized "pressure optimization protocol" (POP) using time to inflation pressure stability as an endpoint for determining the required duration of stent inflation. The primary study purpose was to determine the stent inflation time (IT) in a large patient cohort using the standardized inflation protocol, to correlate various patient and lesion characteristics with IT, and ascertain in an in vitro study the time for pressure accommodation within an inflation system. Six hundred fifteen stent implants in 435 patients were studied. Multivariate analysis was performed to determine predictors of longer ITs. In an in vitro study, various stents and balloons were inflated in air to determine the pressure accommodation time of the inflation system. The mean stent IT was 104 ± 41 sec (range 30-380 sec). Stent length was the only predictor of prolonged stent inflation. The "accommodation time" in vitro of the stent inflation system itself was 33 ± 24 sec. The protocol was safe requiring premature inflation termination in expand the stent and that the use of a pressure stability protocol will allow for safe, predictable, and more complete stent deployment. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  9. Inflation impact of food prices: Case of Serbia

    Directory of Open Access Journals (Sweden)

    Šoškić Dejan

    2015-01-01

    Full Text Available Food prices traditionally have an impact on inflation around the world. Movements in these prices are coming more from the supply side, then from the demand side. If treated as a supply shock, monetary policy should not react. However, food prices are part of headline inflation that is an official target for most central banks. Serbia conducts Inflation targeting and faces serious challenges with food price volatility. Food price volatility in Serbia hampers inflation forecasting, and may have a negative influence on inflationary expectations and public confidence in (i.e. credibility of the Central bank, all of crucial importance for success of Inflation targeting. There are several important possible improvements that may decrease volatility of food prices but also limit negative impact of food price volatility on Consumer Price Index (CPI as a measure of inflation. These improvements are very important for success of Inflation targeting in Serbia.

  10. Evoked corticospinal output to the human scalene muscles is altered by lung volume.

    Science.gov (United States)

    Hudson, Anna L; Taylor, Janet L; Anand, Ashima; Gandevia, Simon C; Butler, Jane E

    2012-03-15

    Increases in lung volume inhibit the inspiratory output from the medulla, but the effect of lung inflation on the voluntary control of breathing in humans is not known. We tested corticospinal excitability using transcranial magnetic stimulation (TMS) to evoke a response in the scalene muscles. TMS was delivered at rest at three different lung volumes between functional residual capacity (FRC) and total lung capacity (TLC) during incremental inspiratory and incremental expiratory manoeuvres. Motor evoked potentials (MEPs) in scalenes were ∼50% larger at a high lung volume (FRC+∼90% inspiratory capacity [IC]) compared to lower lung volumes (FRC and FRC+∼40% IC) in both inspiratory and expiratory manoeuvres (plung inflation on the automatic and voluntary control of breathing in humans. Copyright © 2011 Elsevier B.V. All rights reserved.

  11. Medical image of the week: lung entrapment

    Directory of Open Access Journals (Sweden)

    Natt B

    2016-07-01

    Full Text Available No abstract available. Article truncated at 150 words. A 74-year-old woman with a history of breast cancer 10 years ago treated with lumpectomy and radiation presented for evaluation of shortness of breath. She was diagnosed with left sided pleural effusion which was recurrent requiring multiple thoracenteses. There was increased pleural fludeoxyglucose (FDG uptake on PET-CT indicative of recurrent metastatic disease. She underwent a medical pleuroscopy since the pleural effusion analysis did not reveal malignant cells although the suspicion was high and tunneled pleural catheter placement as adjuvant chemotherapy was initiated. Figure 1 shows a pleurscopic view of the collapsed left lung and the effusion in the left hemi thorax. Figure 2 shows extensive involvement of the visceral pleura with metastatic disease preventing complete lung inflation. Figure 3 shows persistent pneumothorax-ex-vacuo despite pleural catheter placement confirming the diagnosis of entrapment. Incomplete lung inflation can be due to pleural disease, endobronchial lesions or chronic telecasts. Lung entrapment and trapped lung ...

  12. Regional differences in alveolar density in the human lung are related to lung height.

    Science.gov (United States)

    McDonough, John E; Knudsen, Lars; Wright, Alexander C; Elliott, W Mark; Ochs, Matthias; Hogg, James C

    2015-06-01

    The gravity-dependent pleural pressure gradient within the thorax produces regional differences in lung inflation that have a profound effect on the distribution of ventilation within the lung. This study examines the hypothesis that gravitationally induced differences in stress within the thorax also influence alveolar density in terms of the number of alveoli contained per unit volume of lung. To test this hypothesis, we measured the number of alveoli within known volumes of lung located at regular intervals between the apex and base of four normal adult human lungs that were rapidly frozen at a constant transpulmonary pressure, and used microcomputed tomographic imaging to measure alveolar density (number alveoli/mm3) at regular intervals between the lung apex and base. These results show that at total lung capacity, alveolar density in the lung apex is 31.6 ± 3.4 alveoli/mm3, with 15 ± 6% of parenchymal tissue consisting of alveolar duct. The base of the lung had an alveolar density of 21.2 ± 1.6 alveoli/mm3 and alveolar duct volume fraction of 29 ± 6%. The difference in alveolar density can be negated by factoring in the effects of alveolar compression due to the pleural pressure gradient at the base of the lung in vivo and at functional residual capacity.

  13. Observational implications of mattergenesis during inflation

    Science.gov (United States)

    Bastero-Gil, Mar; Berera, Arjun; Ramos, Rudnei O.; Rosa, João G.

    2014-10-01

    The observed baryon asymmetry, as well as potentially an asymmetry in the dark matter sector, can be produced through dissipative particle production during inflation. A distinctive feature of this mechanism is the generation of matter isocurvature perturbations that are fully (anti-)correlated with the dominant adiabatic curvature perturbations. We show that chaotic warm inflation models yield anti-correlated isocurvature modes that may partially or even completely screen the contribution of primordial gravity waves to the CMB temperature power spectrum. The tensor-to-scalar ratio inferred from the latter may thus be parametrically smaller than the one deduced from B-mode polarization maps, which is particularly relevant in the light of the recently announced results of the BICEP2 experiment.

  14. Quintessential inflation in a thawing realization

    Science.gov (United States)

    Agarwal, Abhineet; Myrzakulov, R.; Sami, M.; Singh, Naveen K.

    2017-07-01

    We study quintessential inflation with an inverse hyperbolic type potential V (ϕ) =V0 / cosh ⁡ (ϕn /λn) , where V0, λ and ;n; are parameters of the theory. We obtain a bound on λ for different values of the parameter n. The spectral index and the tensor-to-scalar-ratio fall in the 1σ bound given by the Planck 2015 data for n ≥ 5 for certain values of λ. However for 3 ≤ n fall only within the 2σ bound of the Planck data. Furthermore, we show that the scalar field with the given potential can also give rise to late time acceleration if we invoke the coupling to massive neutrino matter. We also consider the instant preheating mechanism with Yukawa interaction and put bounds on the coupling constants for our model using the nucleosynthesis constraint on relic gravity waves produced during inflation.

  15. Patient satisfaction with Mentor inflatable penile prosthesis.

    Science.gov (United States)

    Whalen, R K; Merrill, D C

    1991-06-01

    Patient satisfaction with the Mentor inflatable penile prosthesis was assessed by sending a thirty-six-item questionnaire to 251 patients who had undergone implantation of the device by the senior author (D.C.M.). A total of 152 (61%) of the patients responded. Recovery time, satisfaction, reasons for dissatisfaction, perceptions of erection quality, and psychosexual parameters were evaluated. Eight-eight percent of the patients were engaging in regular sexual activity. Depending on the definition of satisfaction, 81-89 percent of the respondents reported that they were satisfied with the prosthesis. Sixty-eight percent of the survey group were satisfied with the length, width, and firmness of their prosthetic-induced erection. The majority of patients reported improvement in psychosexual functioning after implantation. Reasons for dissatisfaction included inadequate penile length, insufficient firmness, and difficulty with inflation and deflation of the penile cylinders.

  16. Gravitational Waves from Oscillons after Inflation.

    Science.gov (United States)

    Antusch, Stefan; Cefalà, Francesco; Orani, Stefano

    2017-01-06

    We investigate the production of gravitational waves during preheating after inflation in the common case of field potentials that are asymmetric around the minimum. In particular, we study the impact of oscillons, comparatively long lived and spatially localized regions where a scalar field (e.g., the inflaton) oscillates with large amplitude. Contrary to a previous study, which considered a symmetric potential, we find that oscillons in asymmetric potentials associated with a phase transition can generate a pronounced peak in the spectrum of gravitational waves that largely exceeds the linear preheating spectrum. We discuss the possible implications of this enhanced amplitude of gravitational waves. For instance, for low scale inflation models, the contribution from the oscillons can strongly enhance the observation prospects at current and future gravitational wave detectors.

  17. Tachyacoustic cosmology: An alternative to inflation

    Science.gov (United States)

    Bessada, Dennis; Kinney, William H.; Stojkovic, Dejan; Wang, John

    2010-02-01

    We consider an alternative to inflation for the generation of superhorizon perturbations in the Universe in which the speed of sound is faster than the speed of light. We label such cosmologies, first proposed by Armendariz-Picon, tachyacoustic, and explicitly construct examples of noncanonical Lagrangians which have superluminal sound speed, but which are causally self-consistent. Such models possess two horizons, a Hubble horizon and an acoustic horizon, which have independent dynamics. Even in a decelerating (noninflationary) background, a nearly scale-invariant spectrum of perturbations can be generated by quantum perturbations redshifted outside of a shrinking acoustic horizon. The acoustic horizon can be large or even infinite at early times, solving the cosmological horizon problem without inflation. These models do not, however, dynamically solve the cosmological flatness problem, which must be imposed as a boundary condition. Gravitational wave modes, which are produced by quantum fluctuations exiting the Hubble horizon, are not produced.

  18. Sneutrino Inflation with $\\alpha$-attractors

    CERN Document Server

    Kallosh, Renata; Roest, Diederik; Wrase, Timm

    2016-11-22

    Sneutrino inflation employs the fermionic partners of the inflaton and stabilizer field as right-handed neutrinos to realize the seesaw mechanism for light neutrino masses. A crucial ingredient in existing constructions for sneutrino (multi-)natural inflation is an unbroken discrete shift symmetry. We demonstrate that a similar construction applies to $\\alpha$-attractor models. In this case the hyperbolic geometry protects the neutrino Yukawa couplings to the inflaton field, and the masses of leptons and Higgs fields, from blowing up when the inflaton is super-Planckian. We find that the predictions for $n_s$ and $r$ for $\\alpha$-attractor cosmological models, compatible with the current cosmological data, are preserved in the presence of the neutrino sector.

  19. Modified dispersion relations, inflation, and scale invariance

    Science.gov (United States)

    Bianco, Stefano; Friedhoff, Victor Nicolai; Wilson-Ewing, Edward

    2018-02-01

    For a certain type of modified dispersion relations, the vacuum quantum state for very short wavelength cosmological perturbations is scale-invariant and it has been suggested that this may be the source of the scale-invariance observed in the temperature anisotropies in the cosmic microwave background. We point out that for this scenario to be possible, it is necessary to redshift these short wavelength modes to cosmological scales in such a way that the scale-invariance is not lost. This requires nontrivial background dynamics before the onset of standard radiation-dominated cosmology; we demonstrate that one possible solution is inflation with a sufficiently large Hubble rate, for this slow roll is not necessary. In addition, we also show that if the slow-roll condition is added to inflation with a large Hubble rate, then for any power law modified dispersion relation quantum vacuum fluctuations become nearly scale-invariant when they exit the Hubble radius.

  20. Inflation from nilpotent Kähler corrections

    Energy Technology Data Exchange (ETDEWEB)

    McDonough, Evan [Ernest Rutherford Physics Building, McGill University,3600 University Street, Montréal QC, H3A 2T8 (Canada); Scalisi, Marco [Deutsches Elektronen-Synchrotron, DESY,Notkestraße 85, 22607 Hamburg (Germany)

    2016-11-11

    We develop a new class of supergravity cosmological models where inflation is induced by terms in the Kähler potential which mix a nilpotent superfield S with a chiral sector Φ. As the new terms are non-(anti)holomorphic, and hence cannot be removed by a Kähler transformation, these models are intrinsically Kähler potential driven. Such terms could arise for example due to a backreaction of an anti-D3 brane on the string theory bulk geometry. We show that this mechanism is very general and allows for a unified description of inflation and dark energy, with controllable SUSY breaking at the vacuum. When the internal geometry of the bulk field is hyperbolic, we prove that small perturbative Kähler corrections naturally lead to α-attractor behaviour, with inflationary predictions in excellent agreement with the latest Planck data.

  1. Inflazione e prezzi relativi (Neutrality of inflation

    Directory of Open Access Journals (Sweden)

    F. PADOA-SCHIOPPA

    2014-03-01

    Full Text Available In the traditional Walrasian version of an economy with multi-sectoral exchange, the changes in relative prices and the general level of prices do not influence each other so that inflation is neutral. Various empirical studies in recent times, however, have invalidated this thesis. Unfortunately, they have not provided a well-defined alternative theoretical model, able to explain the formation of prices and rates of inflation in a context of multi-sectoral equilibrium (or disequilibrium. Therefore, some modern versions of neoclassical theory that seem to provide a multi-sectoral analytical foundation to the observed correlation between the dynamics of relative prices and the general level of prices are particularly worthy of interest. Their detailed examination, considered appropriate for both the novelty and complexity of the arguments, and their empirical data on the last two decades in Italy are the subject of the present work. JEL: E31

  2. The Probe of Inflation and Cosmic Origins

    Science.gov (United States)

    Hanany, Shaul; Inflation Probe Mission Study Team

    2018-01-01

    The Probe of Inflation and Cosmic Origins will map the polarization of the cosmic microwave background over the entire sky with unprecedented sensitivity. It will search for gravity wave signals from the inflationary epoch, thus probing quantum gravity and constraining the energy scale of inflation; it will test the standard model of particle physics by measuring the number of light particles in the Universe and the mass of the neutrino; it will elucidate the nature of dark matter and search for new forms of matter in the early Universe; it will constrain star formation history over cosmic time; and it will determine the mechanisms of structure formation from galaxy cluster to stellar scales. I will review the status of design of this probe-scale mission.

  3. Grade Inflation Rates among Different Ability Students

    Directory of Open Access Journals (Sweden)

    Stephanie Mc Spirit

    1999-09-01

    Full Text Available This study compares grade inflation rates among different ability students at a large, open admissions public University. Specifically, this study compares trends in graduating grade point average (GPA from 1983 to 1996 across low, typical and higher ability students. This study also tests other explanations for increases in graduating GPA. These other explanations are changes in 1 ACT score 2 gender 3 college major and 4 vocational programs. With these other explanations considered, regression results still report an inflationary trend in graduating GPA. Time, as measured by college entry year, is still a significant positive predictor of GPA. More directly, comparisons of regression coefficients reveal lower ability students as experiencing the highest rate of grade increase. Higher grade inflation rates among low aptitude students suggest that faculty might be using grades to encourage learning among marginal students.

  4. Inflating Kahler moduli and primordial magnetic fields

    Directory of Open Access Journals (Sweden)

    Luis Aparicio

    2017-05-01

    Full Text Available We study the production of primordial magnetic fields in inflationary models in type IIB string theory where the role of the inflaton is played by a Kahler modulus. We consider various possibilities to realise the Standard Model degrees of freedom in this setting and explicitly determine the time dependence of the inflaton coupling to the Maxwell term in the models. Using this we determine the strength and scale dependence of the magnetic fields generated during inflation. The usual “strong coupling problem” for primordial magnetogenesis manifests itself by cycle sizes approaching the string scale; this appears in a certain class of fibre inflation models where the standard model is realised by wrapping D7-branes on cycles in the geometric regime.

  5. Inflating Kahler moduli and primordial magnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Aparicio, Luis, E-mail: laparici@ictp.it [Abdus Salam ICTP, Strada Costiera 11, Trieste 34014 (Italy); Maharana, Anshuman, E-mail: anshumanmaharana@hri.res.in [Harish Chandra Research Institute, HBNI, Chattnag Road, Jhunsi, Allahabad 211019 (India)

    2017-05-10

    We study the production of primordial magnetic fields in inflationary models in type IIB string theory where the role of the inflaton is played by a Kahler modulus. We consider various possibilities to realise the Standard Model degrees of freedom in this setting and explicitly determine the time dependence of the inflaton coupling to the Maxwell term in the models. Using this we determine the strength and scale dependence of the magnetic fields generated during inflation. The usual “strong coupling problem” for primordial magnetogenesis manifests itself by cycle sizes approaching the string scale; this appears in a certain class of fibre inflation models where the standard model is realised by wrapping D7-branes on cycles in the geometric regime.

  6. Plateau inflation in SUGRA-MSSM

    Directory of Open Access Journals (Sweden)

    Girish Kumar Chakravarty

    2016-09-01

    Full Text Available We explored a Higgs inflationary scenario in the SUGRA embedding of the MSSM in Einstein frame where the inflaton is contained in the SU(2 Higgs doublet. We include all higher order non-renormalizable terms to the MSSM superpotential and an appropriate Kähler potential which can provide slow-roll inflaton potential in the D-flat direction. In this model, a plateau-like inflation potential can be obtained if the imaginary part of the neutral Higgs acts as the inflaton. The inflationary predictions of this model are consistent with the latest CMB observations. The model represents a successful Higgs inflation scenario in the context of Supergravity and it is compatible with Minimal Supersymmetric extension of the Standard Model.

  7. Logamediate Inflation in f ( T ) Teleparallel Gravity

    Energy Technology Data Exchange (ETDEWEB)

    Rezazadeh, Kazem; Karami, Kayoomars [Department of Physics, University of Kurdistan, Pasdaran Street, P.O. Box 66177-15175, Sanandaj (Iran, Islamic Republic of); Abdolmaleki, Asrin, E-mail: rezazadeh86@gmail.com [Research Institute for Astronomy and Astrophysics of Maragha (RIAAM), P.O. Box 55134-441, Maragha (Iran, Islamic Republic of)

    2017-02-20

    We study logamediate inflation in the context of f ( T ) teleparallel gravity. f ( T )-gravity is a generalization of the teleparallel gravity which is formulated on the Weitzenbock spacetime, characterized by the vanishing curvature tensor (absolute parallelism) and the non-vanishing torsion tensor. We consider an f ( T )-gravity model which is sourced by a canonical scalar field. Assuming a power-law f ( T ) function in the action, we investigate an inflationary universe with a logamediate scale factor. Our results show that, although logamediate inflation is completely ruled out by observational data in the standard inflationary scenario based on Einstein gravity, it can be compatible with the 68% confidence limit joint region of Planck 2015 TT,TE,EE+lowP data in the framework of f ( T )-gravity.

  8. Seeded hot dark matter models with inflation

    Science.gov (United States)

    Gratsias, John; Scherrer, Robert J.; Steigman, Gary; Villumsen, Jens V.

    1993-01-01

    We examine massive neutrino (hot dark matter) models for large-scale structure in which the density perturbations are produced by randomly distributed relic seeds and by inflation. Power spectra, streaming velocities, and the Sachs-Wolfe quadrupole fluctuation are derived for this model. We find that the pure seeded hot dark matter model without inflation produces Sachs-Wolfe fluctuations far smaller than those seen by COBE. With the addition of inflationary perturbations, fluctuations consistent with COBE can be produced. The COBE results set the normalization of the inflationary component, which determines the large-scale (about 50/h Mpc) streaming velocities. The normalization of the seed power spectrum is a free parameter, which can be adjusted to obtain the desired fluctuations on small scales. The power spectra produced are very similar to those seen in mixed hot and cold dark matter models.

  9. Injurious mechanical ventilation in the normal lung causes a progressive pathologic change in dynamic alveolar mechanics

    OpenAIRE

    Pavone, Lucio A.; Albert, Scott; Carney, David; Gatto, Louis A.; Halter, Jeffrey M; Nieman, Gary F.

    2007-01-01

    Introduction Acute respiratory distress syndrome causes a heterogeneous lung injury, and without protective mechanical ventilation a secondary ventilator-induced lung injury can occur. To ventilate noncompliant lung regions, high inflation pressures are required to 'pop open' the injured alveoli. The temporal impact, however, of these elevated pressures on normal alveolar mechanics (that is, the dynamic change in alveolar size and shape during ventilation) is unknown. In the present study we ...

  10. Physical Theories, Eternal Inflation, and Quantum Universe

    OpenAIRE

    Nomura, Yasunori

    2011-01-01

    We present a framework in which well-defined predictions are obtained in an eternally inflating multiverse, based on the principles of quantum mechanics. We show that the entire multiverse is described purely from the viewpoint of a single "observer," who describes the world as a quantum state defined on his/her past light cones bounded by the (stretched) apparent horizons. We find that quantum mechanics plays an essential role in regulating infinities. The framework is "gauge invariant," i.e...

  11. Static response of elastic inflated wrinkled membranes

    Science.gov (United States)

    Barsotti, Riccardo; Ligarò, Salvatore S.

    2014-05-01

    In this paper we present an effective numerical algorithm for determining the equilibrium shapes of inflated elastic membranes susceptible to wrinkling. The use of a two-state constitutive law and the introduction of a suitable criterion allow for accounting for wrinkling of the membrane, although in an approximated way. In the active state, the material is able to transmit only tensile stresses; vice versa, in the passive state it is stress-free and can contract freely. Equilibrium of the membrane in the current inflated configuration is enforced by recourse to the minimum total potential energy principle, whereas the Lagrange multipliers method is used to solve the minimum problem by accounting for the aforesaid nonlinear constitutive law. We use an expressly developed iterative-incremental numerical algorithm, consistent with the established governing set of equations, for accurately monitoring the evolution of the stress field in the membrane during the inflation process. Specifically, we suppose that the membrane reaches its final shape at the end of a four-stage loading process corresponding to the temporary enforcement and the subsequent removal of a fictitious antagonist plane traction acting uniformly along its entire boundary. By this way it is possible to solve with great accuracy the set of governing equilibrium equations by means of a numerical procedure in which the membrane's tangent stiffness is always kept different from zero. The soundness of the proposed algorithm is verified by comparing the results with well-known solutions available in the literature. In particular, for each specific value of pressure, the current configuration of the inflated membrane found by assuming that compressions are allowed is compared in details to the corresponding pseudo-deformed surface, obtained by assuming a tension-only response.

  12. Inflation in the universe, Circa 1986

    Energy Technology Data Exchange (ETDEWEB)

    Turner, M.S.

    1986-12-01

    The hot big bang cosmology, or the standard cosmology as it is appropriately known, is a highly successful model, providing a reliable and tested accounting of the Universe from 0.01 sec after the bang until today, some 15 Gyr later. However, very special initial data seem to be required in order to account for the observed smoothness and flatness of our Hubble volume and for the existence of the small primeval density inhomogeneities required for the formation of structure in the Universe. Inflation offers a means of accounting for these special initial data which is based upon physics at sub-planck energy scales (<inflation as the scalar field relaxes, resulting in a Universe today which resembles ours in regions much larger than our present Hubble volume (approx. =10/sup 28/ cm), but which on very large scales (>>10/sup 28/ cm) may be a highly irregular. At present, the most conspicuous blemish on the paradigm is the lack of a compelling particle physics model to implement it. Some other unresolved issues facing inflation, including the confrontation between inflation and observational data are also reviewed. 112 refs., 4 figs.

  13. Primordial Inflation Polarization Explorer: Status and Plans

    Science.gov (United States)

    Kogut, Alan

    2009-01-01

    The Primordial Inflation Polarization Explorer is a balloon-borne instrument to measure the polarization of the cosmic microwave background in order to detect the characteristic signature of gravity waves created during an inflationary epoch in the early universe. PIPER combines cold /I.G K\\ optics, 5120 bolometric detectors, and rapid polarization modulation using VPM grids to achieve both high sensitivity and excellent control of systematic errors. I will discuss the current status and plans for the PIPER instrument.

  14. Knotty inflation and the dimensionality of spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Berera, Arjun [University of Edinburgh, Tait Institute, School of Physics and Astronomy, Edinburgh (United Kingdom); Buniy, Roman V. [Chapman University, Schmid College of Science, Orange, CA (United States); Kephart, Thomas W. [Vanderbilt University, Department of Physics and Astronomy, Nashville, TN (United States); Paes, Heinrich [Technische Universitaet Dortmund, Fakultaet fuer Physik, Dortmund (Germany); Rosa, Joao G. [Departamento de Fisica da Universidade de Aveiro and CIDMA, Aveiro (Portugal)

    2017-10-15

    We suggest a structure for the vacuum comprised of a network of tightly knotted/linked flux tubes formed in a QCD-like cosmological phase transition and show that such a network can drive cosmological inflation. As the network can be topologically stable only in three space dimensions, this scenario provides a dynamical explanation for the existence of exactly three large spatial dimensions in our Universe. (orig.)

  15. Utility of inflation accounting data to investors

    OpenAIRE

    Byrne, Marann

    1992-01-01

    The objective of financial reporting is to provide information about an entity which is useful to a wide range of users in making economic decisions. This study empirically investigates the utility of inflation accounting data to investors, by examining the ability of this data to explain the share prices of UK listed companies. Previous research supports a relation between historical cost accounting data and share prices from a conceptual and empirical perspective. Prior evidence from studie...

  16. New Approaches to Defense Inflation and Discounting

    Science.gov (United States)

    2013-01-01

    market’s preference for current consumption and the percep- tion of the uncertainty in repayment due to risk of default. Inflation expectations also...the artisan loaf to the store brand, buying less bread and more rice , or even switching from the local grocery chain to a discount store. Notably, the...include food, beverages , apparel, insurance, transportation, recreation, and education, along with communica- tion, tobacco, personal services, and

  17. Self-Healing, Inflatable, Rigidizable Shelter

    Science.gov (United States)

    Haight, Andrea; Gosau, Jan-Michael; Dixit, Anshu; Gleeson, Dan

    2012-01-01

    An inflatable, rigidizable shelter system was developed based on Rigi dization on Command (ROC) technology incorporating not only the requ ired low-stowage volume and lightweight character achieved from an i nflatable/rigidizable system, but also a self-healing foam system inc orporated between the rigidizable layers of the final structure to m inimize the damage caused by any punctures to the structure.

  18. Fluctuations along supersymmetric flat directions during Inflation

    OpenAIRE

    Enqvist, Kari; Figueroa, Daniel G.; Rigopoulos, Gerasimos

    2011-01-01

    We consider a set of scalar fields, consisting of a single flat direction and one or several non-flat directions. We take our cue from the MSSM, considering separately D-flat and F-flat directions, but our results apply to any supersymmetric scenario containing flat directions. We study the field fluctuations during pure de Sitter Inflation, following the evolution of the infrared modes by numerically solving the appropriate Langevin equations. We demonstrate that for the Standard Model U(1),...

  19. A Jacobian elliptic single-field inflation

    Energy Technology Data Exchange (ETDEWEB)

    Villanueva, J.R. [Universidad de Valparaiso, Instituto de Fisica y Astronomia, Valparaiso (Chile); Centro de Astrofisica de Valparaiso, Valparaiso (Chile); Gallo, Emanuel [FaMAF, Universidad Nacional de Cordoba, Cordoba (Argentina); Instituto de Fisica Enrique Gaviola (IFEG), CONICET, Cordoba (Argentina)

    2015-06-15

    In the scenario of single-field inflation, this field is described in terms of Jacobian elliptic functions. This approach provides, when constrained to particular cases, analytic solutions already known in the past, generalizing them to a bigger family of analytical solutions. The emergent cosmology is analyzed using the Hamilton-Jacobi approach and then the main results are contrasted with the recent measurements obtained from the Planck 2015 data. (orig.)

  20. Finite Inflation, Holography, and Dark Matter Annihilation

    Science.gov (United States)

    Scacco, Andrew Joseph

    This thesis covers work on theoretical cosmology relating to inflation, de Sitter space, dark matter annihilation, and holography. A unifying feature of all these topics is that all of them occur in de Sitter space or focus on epochs of the Universe when the spacetime was close to de Sitter and that all of them have some connection to holography. Chapter 1 provides a pedagogical introduction to the fundamentals of cosmology, inflation, de Sitter space, dark matter annihilation and entanglement entropy. Chapter 2 covers the impact on the causal entropic principle of dark matter annihilation that we find to have the greatest relevance at late times in the future when the dark energy has driven the universe to be asymptotically de Sitter. In this chapter we estimate holographically preferred dark matter properties for a range of assumptions. Chapter 3 covers holographic bounds in models of finite inflation, specifically the Banks-Fischler bound and de Sitter equilibrium. The assumptions in each of these models are explored in detail and some interesting new connections are presented. Chapter 4 tests models of inflation with a fast-roll start that happen to satisfy the holographic bounds in Chapter 3 against cosmic microwave background data from Planck. We find a slight preference for a feature at the scale predicted by the Banks-Fischler bound though this preference is not found to be statistically significant. Chapter 5 contains a numerical computation of the holographic mutual information for an annular configuration of regions on a conformal field theory in de Sitter space using the AdS/CFT correspondence. This computation shows that the de Sitter space CFT entanglement entropy matches what would be expected from a Minkowski CFT and shows that the HRT conjecture works for this case.

  1. Hilltop supernatural inflation and gravitino problem

    Energy Technology Data Exchange (ETDEWEB)

    Kohri, Kazunori [Cosmophysics group, Theory Center, IPNS, KEK, Tsukuba 305-0801 (Japan); Lin, Chia-Min, E-mail: kohri@post.kek.jp, E-mail: cmlin@phys.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu, Taiwan 300 (China)

    2010-11-01

    In this paper, we explore the parameter space of hilltop supernatural inflation model and show the regime within which there is no gravitino problem even if we consider both thermal and nonthermal production mechanisms. We make plots for the allowed reheating temperature as a function of gravitino mass by constraints from big-bang nucleosynthesis. We also plot the constraint when gravitino is assumed to be stable and plays the role of dark matter.

  2. Non-Gaussianity from Axion Monodromy Inflation

    CERN Document Server

    Hannestad, Steen; Jarnhus, Philip R; Sloth, Martin S

    2010-01-01

    We study the primordial non-Gaussinity predicted from simple models of inflation with a linear potential and superimposed oscillations. This generic form of the potential is predicted by the axion monodromy inflation model, that has recently been proposed as a possible realization of chaotic inflation in string theory, where the monodromy from wrapped branes extends the range of the closed string axions to beyond the Planck scale. The superimposed oscillations in the potential can lead to new signatures in the CMB spectrum and bispectrum. In particular the bispectrum will have a new distinct shape. We calculate the power spectrum and bispectrum of curvature perturbations in the model, as well as make analytic estimates in various limiting cases. From the numerical analysis we find that for a wide range of allowed parameters the model produces a feature in the bispectrum with fnl ~ 50 or larger while the power spectrum is almost featureless. This model is therefore an example of a string-inspired inflationary ...

  3. Constraining warm inflation with CMB data

    Science.gov (United States)

    Bastero-Gil, Mar; Bhattacharya, Sukannya; Dutta, Koushik; Gangopadhyay, Mayukh Raj

    2018-02-01

    We confront the warm inflation observational predictions directly with the latest CMB data. We focus on a linear temperature (T) dissipative coefficient combined with the simplest model of inflation, a quartic chaotic potential. Although excluded in its standard cold inflation version, dissipation reduces the tensor-to-scalar ratio and brings the quartic chaotic model within the observable allowed range. We will use the CosmoMC package to derive constraints on the model parameters: the combination of coupling constants giving rise to dissipation, the effective number of relativistic degrees of freedom contributing to the thermal bath, and the quartic coupling in the inflaton potential. We do not assume a priori a power-law primordial spectrum, neither we fix the no. of e-folds at the horizon exit. The relation between the no. of e-folds and the comoving scale at horizon crossing is derived from the dynamics, depending on the parameters of the model, which allows us to obtain the k-dependent primordial power spectrum. We study the two possibilities considered in the literature for the spectrum, with the inflaton fluctuations having a thermal or a non-thermal origin, and discuss the ability of the data to constraint the model parameters.

  4. Magnon Inflation: Slow Roll with Steep Potentials

    CERN Document Server

    Adshead, Peter; Burgess, C P; Hayman, Peter; Patil, Subodh P

    2016-01-01

    We find multi-scalar effective field theories (EFTs) that can achieve a slow inflationary roll despite having a scalar potential that does not satisfy the usual slow-roll condition (d V)^2 << V^2/Mp^2. They evade the usual slow-roll conditions on $V$ because their kinetic energies are dominated by single-derivative terms rather than the usual two-derivative terms. Single derivatives dominate during slow roll and so do not require a breakdown of the usual derivative expansion that underpins calculational control in much of cosmology. The presence of such terms requires some sort of UV Lorentz-symmetry breaking during inflation (besides the usual cosmological breaking). Chromo-natural inflation provides an example of a UV theory that can generate the multi-field single-derivative terms we consider, and we argue that the EFT we find indeed captures the slow-roll conditions for the background evolution for Chromo-natural inflation. We also show that our EFT can be understood as a multi-field generalization ...

  5. The goldstone and goldstino of supersymmetric inflation

    Energy Technology Data Exchange (ETDEWEB)

    Kahn, Yonatan; Roberts, Daniel A.; Thaler, Jesse [Center for Theoretical Physics, Massachusetts Institute of Technology,77 Massachusetts Ave, Cambridge, MA 02139 (United States)

    2015-10-01

    We construct the minimal effective field theory (EFT) of supersymmetric inflation, whose field content is a real scalar, the goldstone for time-translation breaking, and a Weyl fermion, the goldstino for supersymmetry (SUSY) breaking. The inflating background can be viewed as a single SUSY-breaking sector, and the degrees of freedom can be efficiently parameterized using constrained superfields. Our EFT is comprised of a chiral superfield X{sub NL} containing the goldstino and satisfying X{sub NL}{sup 2}=0, and a real superfield B{sub NL} containing both the goldstino and the goldstone, satisfying X{sub NL}B{sub NL}=B{sub NL}{sup 3}=0. We match results from our EFT formalism to existing results for SUSY broken by a fluid background, showing that the goldstino propagates with subluminal velocities. The same effect can also be derived from the unitary gauge gravitino action after embedding our EFT in supergravity. If the gravitino mass is comparable to the Hubble scale during inflation, we identify a new parameter in the EFT related to a time-dependent phase of the gravitino mass parameter. We briefly comment on the leading contributions of goldstino loops to inflationary observables.

  6. Inflatable Emergency Atmospheric-Entry Vehicles

    Science.gov (United States)

    Jones, Jack; Hall, Jeffrey; Wu, Jiunn Jeng

    2004-01-01

    In response to the loss of seven astronauts in the Space Shuttle Columbia disaster, large, lightweight, inflatable atmospheric- entry vehicles have been proposed as means of emergency descent and landing for persons who must abandon a spacecraft that is about to reenter the atmosphere and has been determined to be unable to land safely. Such a vehicle would act as an atmospheric decelerator at supersonic speed in the upper atmosphere, and a smaller, central astronaut pod could then separate at lower altitudes and parachute separately to Earth. Astronaut-rescue systems that have been considered previously have been massive, and the cost of designing them has exceeded the cost of fabrication of a space shuttle. In contrast, an inflatable emergency-landing vehicle according to the proposal would have a mass between 100 and 200 kg, could be stored in a volume of approximately 0.2 to 0.4 cu m, and could likely be designed and built much less expensively. When fully inflated, the escape vehicle behaves as a large balloon parachute, or ballute. Due to very low mass-per-surface area, a large radius, and a large coefficient of drag, ballutes decelerate at much higher altitudes and with much lower heating rates than the space shuttle. Although the space shuttle atmospheric reentry results in surface temperatures of about 1,600 C, ballutes can be designed for maximum temperatures below 600 C. This allows ballutes to be fabricated with lightweight ZYLON(Registered TradeMark) or polybenzoxazole (PBO), or equivalent.

  7. Revision of mass inflation inside black holes

    CERN Document Server

    Dokuchaev, Vyacheslav I

    2013-01-01

    The mass inflation phenomenon implies that the black hole interiors are unstable due to a back-reaction divergence of the perturbed black hole mass function at the Cauchy horizon. The mass inflation was initially derived by using the generalized Dray-t'\\,Hooft-Redmount (DTR) relation in the linear approximation of the Einstein equations near the perturbed Cauchy horizon. However, this linear approximation for the DTR relation is improper for the highly nonlinear behavior of back reaction perturbations near horizons. An additional weak point in the standard mass inflation calculations is in a fallacious using of the global Cauchy horizon as a place for the maximally growing back reaction perturbations instead of the local inner apparent horizon. It is derived the new spherically symmetric back reaction solution by considering the back-reaction of two counter-streaming light-like fluxes near the inner apparent horizon of the charged black hole. In this solution the back reaction perturbations of the black hole ...

  8. Inflation and Reheating in Spontaneously Generated Gravity

    CERN Document Server

    Cerioni, A; Tronconi, A; Venturi, G

    2010-01-01

    Inflation is studied in the context of induced gravity (IG) $\\gamma \\sigma^2 R$, where $R$ is the Ricci scalar, $\\sigma$ a scalar field and $\\gamma$ a dimensionless constant, and diverse symmetry-breaking potentials $V(\\sigma)$ are considered. In particular we compared the predictions for Landau-Ginzburg (LG) and Coleman-Weinberg (CW) type potentials and their possible generalizations with the most recent data. We find that large field inflation generally leads to fewer constraints on the parameters and the shape of the potential whereas small field inflation is more problematic and, if viable, implies more constraints, in particular on the parameter $\\gamma$. We also examined the reheating phase and obtained an accurate analytical solution for the dynamics of inflaton and the Hubble parameter by using a multiple scale analysis (MSA). The solutions were then used to study the average expansion of the Universe, the average equation of state for the scalar field and both the perturbative and resonant decays of ...

  9. Does money matter in inflation forecasting?

    Science.gov (United States)

    Binner, J. M.; Tino, P.; Tepper, J.; Anderson, R.; Jones, B.; Kendall, G.

    2010-11-01

    This paper provides the most fully comprehensive evidence to date on whether or not monetary aggregates are valuable for forecasting US inflation in the early to mid 2000s. We explore a wide range of different definitions of money, including different methods of aggregation and different collections of included monetary assets. In our forecasting experiment we use two nonlinear techniques, namely, recurrent neural networks and kernel recursive least squares regression-techniques that are new to macroeconomics. Recurrent neural networks operate with potentially unbounded input memory, while the kernel regression technique is a finite memory predictor. The two methodologies compete to find the best fitting US inflation forecasting models and are then compared to forecasts from a naïve random walk model. The best models were nonlinear autoregressive models based on kernel methods. Our findings do not provide much support for the usefulness of monetary aggregates in forecasting inflation. Beyond its economic findings, our study is in the tradition of physicists’ long-standing interest in the interconnections among statistical mechanics, neural networks, and related nonparametric statistical methods, and suggests potential avenues of extension for such studies.

  10. Natural inflation with hidden scale invariance

    Directory of Open Access Journals (Sweden)

    Neil D. Barrie

    2016-05-01

    Full Text Available We propose a new class of natural inflation models based on a hidden scale invariance. In a very generic Wilsonian effective field theory with an arbitrary number of scalar fields, which exhibits scale invariance via the dilaton, the potential necessarily contains a flat direction in the classical limit. This flat direction is lifted by small quantum corrections and inflation is realised without need for an unnatural fine-tuning. In the conformal limit, the effective potential becomes linear in the inflaton field, yielding to specific predictions for the spectral index and the tensor-to-scalar ratio, being respectively: ns−1≈−0.025(N⋆60−1 and r≈0.0667(N⋆60−1, where N⋆≈30–65 is a number of efolds during observable inflation. This predictions are in reasonable agreement with cosmological measurements. Further improvement of the accuracy of these measurements may turn out to be critical in falsifying our scenario.

  11. Primordial Inflation Polarization Explorer (Phase 2)

    Science.gov (United States)

    Kogurt, Alan; Bennett, Charles

    This is the Lead Proposal for the proposed investigation "Primordial Inflation Polarization Explorer (Phase 2)" We propose to fly the Primordial Inflation Polarization Explorer (PIPER) to measure the polarization of the cosmic microwave background (CMB) and search for the imprint of gravitational waves produced during an inflationary epoch in the early universe. Such a signal is expected to exist: the simplest inflation models predict tensor-to-scalar ratio 0.01 architecture combines cryogenic optics with kilo-pixel detector arrays to provide unprecedented sensitivity to CMB polarization. The fast modulation between linear and circular polarization takes advantage of the lack of astrophysical circular polarization to eliminate common sources of systematic error. The sensitivity and control of systematic errors in turn enable measurements over most of the sky from mid-latitude launch sites; long-duration Antarctic flights are not required. With sensitivity r papers for the ground-breaking COBE-DMR, COBE-FIRAS, and WMAP instruments. The team has demonstrated expertise in data analysis including pipeline development, foreground modeling, and cosmological parameter fitting. PIPER began development in 2009 and is nearing completion. With first flight scheduled soon, the development schedule compares favorably to other suborbital CMB instruments of similar complexity. PIPER will probe the limits of sensitivity from a suborbital platform while developing instrumentation, observing techniques, and foreground models for an eventual space mission.

  12. Is cosmological constant needed in Higgs inflation?

    Directory of Open Access Journals (Sweden)

    Chao-Jun Feng

    2014-11-01

    Full Text Available The detection of B-mode shows a very powerful constraint to theoretical inflation models through the measurement of the tensor-to-scalar ratio r. Higgs boson is the most likely candidate of the inflaton field. But usually, Higgs inflation models predict a small value of r, which is not quite consistent with the recent results from BICEP2. In this paper, we explored whether a cosmological constant energy component is needed to improve the situation. And we found the answer is yes. For the so-called Higgs chaotic inflation model with a quadratic potential, it predicts r≈0.2, ns≈0.96 with e-folds number N≈56, which is large enough to overcome the problems such as the horizon problem in the Big Bang cosmology. The required energy scale of the cosmological constant is roughly Λ∼(1014 GeV2, which means a mechanism is still needed to solve the fine-tuning problem in the later time evolution of the universe, e.g. by introducing some dark energy component.

  13. Hypersonic Inflatable Aerodynamic Decelerator Ground Test Development

    Science.gov (United States)

    Del Corso, Jospeh A.; Hughes, Stephen; Cheatwood, Neil; Johnson, Keith; Calomino, Anthony

    2015-01-01

    Hypersonic Inflatable Aerodynamic Decelerator (HIAD) technology readiness levels have been incrementally matured by NASA over the last thirteen years, with most recent support from NASA's Space Technology Mission Directorate (STMD) Game Changing Development Program (GCDP). Recently STMD GCDP has authorized funding and support through fiscal year 2015 (FY15) for continued HIAD ground developments which support a Mars Entry, Descent, and Landing (EDL) study. The Mars study will assess the viability of various EDL architectures to enable a Mars human architecture pathfinder mission planned for mid-2020. At its conclusion in November 2014, NASA's first HIAD ground development effort had demonstrated success with fabricating a 50 W/cm2 modular thermal protection system, a 400 C capable inflatable structure, a 10-meter scale aeroshell manufacturing capability, together with calibrated thermal and structural models. Despite the unquestionable success of the first HIAD ground development effort, it was recognized that additional investment was needed in order to realize the full potential of the HIAD technology capability to enable future flight opportunities. The second HIAD ground development effort will focus on extending performance capability in key technology areas that include thermal protection system, lifting-body structures, inflation systems, flight control, stage transitions, and 15-meter aeroshell scalability. This paper presents an overview of the accomplishments under the baseline HIAD development effort and current plans for a follow-on development effort focused on extending those critical technologies needed to enable a Mars Pathfinder mission.

  14. Lung volume recruitment in multiple sclerosis.

    Science.gov (United States)

    Srour, Nadim; LeBlanc, Carole; King, Judy; McKim, Douglas A

    2013-01-01

    Pulmonary function abnormalities have been described in multiple sclerosis including reductions in forced vital capacity (FVC) and cough but the time course of this impairment is unknown. Peak cough flow (PCF) is an important parameter for patients with respiratory muscle weakness and a reduced PCF has a direct impact on airway clearance and may therefore increase the risk of respiratory tract infections. Lung volume recruitment is a technique that improves PCF by inflating the lungs to their maximal insufflation capacity. Our goals were to describe the rate of decline of pulmonary function and PCF in patients with multiple sclerosis and describe the use of lung volume recruitment in this population. We reviewed all patients with multiple sclerosis referred to a respiratory neuromuscular rehabilitation clinic from February 1999 until December 2010. Lung volume recruitment was attempted in patients with FVC lung volume recruitment was prescribed if it resulted in a significant improvement in the laboratory. There were 79 patients included, 35 of whom were seen more than once. A baseline FVC Lung volume recruitment was associated with a slower decline in FVC (plung volume recruitment is associated with a slower rate of decline in lung function and peak cough flow. Given design limitations, additional studies are needed to assess the role of lung volume recruitment in patients with multiple sclerosis.

  15. Lung Recruitment Assessed by Respiratory Mechanics and Computed Tomography in Patients with Acute Respiratory Distress Syndrome. What Is the Relationship?

    Science.gov (United States)

    Chiumello, Davide; Marino, Antonella; Brioni, Matteo; Cigada, Irene; Menga, Federica; Colombo, Andrea; Crimella, Francesco; Algieri, Ilaria; Cressoni, Massimo; Carlesso, Eleonora; Gattinoni, Luciano

    2016-06-01

    The assessment of lung recruitability in patients with acute respiratory distress syndrome (ARDS) may be important for planning recruitment maneuvers and setting positive end-expiratory pressure (PEEP). To determine whether lung recruitment measured by respiratory mechanics is comparable with lung recruitment measured by computed tomography (CT). In 22 patients with ARDS, lung recruitment was assessed at 5 and 15 cm H2O PEEP by using respiratory mechanics-based methods: (1) increase in gas volume between two pressure-volume curves (P-Vrs curve); (2) increase in gas volume measured and predicted on the basis of expected end-expiratory lung volume and static compliance of the respiratory system (EELV-Cst,rs); as well as by CT scan: (3) decrease in noninflated lung tissue (CT [not inflated]); and (4) decrease in noninflated and poorly inflated tissue (CT [not + poorly inflated]). The P-Vrs curve recruitment was significantly higher than EELV-Cst,rs recruitment (423 ± 223 ml vs. 315 ± 201 ml; P respiratory mechanics was 54 ± 28% (P-Vrs curve) and 39 ± 25% (EELV-Cst,rs) of the gas volume at 5 cm H2O PEEP. Recruitment measured by CT scan was 5 ± 5% (CT [not inflated]) and 6 ± 6% (CT [not + poorly inflated]) of lung tissue. Respiratory mechanics and CT measure-under the same term, "recruitment"-two different entities. The respiratory mechanics-based methods include gas entering in already open pulmonary units that improve their mechanical properties at higher PEEP. Consequently, they can be used to assess the overall improvement of inflation. The CT scan measures the amount of collapsed tissue that regains inflation. Clinical trial registered with www.clinicaltrials.gov (NCT00759590).

  16. Reconstruction of Orion Engineering Development Unit (EDU) Parachute Inflation Loads

    Science.gov (United States)

    Ray, Eric S.

    2013-01-01

    The process of reconstructing inflation loads of Capsule Parachute Assembly System (CPAS) has been updated as the program transitioned to testing Engineering Development Unit (EDU) hardware. The equations used to reduce the test data have been re-derived based on the same physical assumptions made by simulations. Due to instrumentation challenges, individual parachute loads are determined from complementary accelerometer and load cell measurements. Cluster inflations are now simulated by modeling each parachute individually to better represent different inflation times and non-synchronous disreefing. The reconstruction procedure is tailored to either infinite mass or finite mass events based on measurable characteristics from the test data. Inflation parameters are determined from an automated optimization routine to reduce subjectivity. Infinite mass inflation parameters have been re-defined to avoid unrealistic interactions in Monte Carlo simulations. Sample cases demonstrate how best-fit inflation parameters are used to generate simulated drag areas and loads which favorably agree with test data.

  17. Portfolio Management with Stochastic Interest Rates and Inflation Ambiguity

    DEFF Research Database (Denmark)

    Munk, Claus; Rubtsov, Alexey Vladimirovich

    We solve a stock-bond-cash portfolio choice problem for a risk- and ambiguity-averse investor in a setting where the inflation rate and interest rates are stochastic. The expected inflation rate is unobservable, but the investor may learn about it from realized inflation and observed stock and bond...... prices. The investor is aware that his model for the observed inflation is potentially misspecified, and he seeks an investment strategy that maximizes his expected utility from real terminal wealth and is also robust to inflation model misspecification. We solve the corresponding robust Hamilton......-Jacobi-Bellman equation in closed form and derive and illustrate a number of interesting properties of the solution. For example, ambiguity aversion affects the optimal portfolio through the correlation of price level with the stock index, a bond, and the expected inflation rate. Furthermore, unlike other settings...

  18. Forecasting inflation with gradual regime shifts and exogenous information

    DEFF Research Database (Denmark)

    González, Andrés; Hubrich, Kirstin; Teräsvirta, Timo

    In this work, we make use of the shifting-mean autoregressive model which is a flexible univariate nonstationary model. It is suitable for describing characteristic features in inflation series as well as for medium-term forecasting. With this model we decompose the inflation process into a slowly...... moving nonstationary component and dynamic short-run fluctuations around it. We fit the model to the monthly euro area, UK and US inflation series. An important feature of our model is that it provides a way of combining the information in the sample and the a priori information about the quantity...... to be forecast to form a single inflation forecast. We show, both theoretically and by simulations, how this is done by using the penalised likelihood in the estimation of model parameters. In forecasting inflation, the central bank inflation target, if it exists, is a natural example of such prior information...

  19. The Observational Status of Cosmic Inflation After Planck

    Science.gov (United States)

    Martin, Jérôme

    The observational status of inflation after the Planck 2013 and 2015 results and the BICEP2/Keck Array and Planck joint analysis is discussed. These pedagogical lecture notes are intended to serve as a technical guide filling the gap between the theoretical articles on inflation and the experimental works on astrophysical and cosmological data. After a short discussion of the central tenets at the basis of inflation (negative self-gravitating pressure) and its experimental verifications, it reviews how the most recent Cosmic Microwave Background (CMB) anisotropy measurements constrain cosmic inflation. The fact that vanilla inflationary models are, so far, preferred by the observations is discussed and the reason why plateau-like potential versions of inflation are favored within this subclass of scenarios is explained. Finally, how well the future measurements, in particular of B-Mode CMB polarization or primordial gravity waves, will help to improve our knowledge about inflation is also investigated.

  20. Pneumothorax as a complication of lung volume recruitment

    Directory of Open Access Journals (Sweden)

    Erik J.A. Westermann

    2013-06-01

    Full Text Available Lung volume recruitment involves deep inflation techniques to achieve maximum insufflation capacity in patients with respiratory muscle weakness, in order to increase peak cough flow, thus helping to maintain airway patency and improve ventilation. One of these techniques is air stacking, in which a manual resuscitator is used in order to inflate the lungs. Although intrathoracic pressures can rise considerably, there have been no reports of respiratory complications due to air stacking. However, reaching maximum insufflation capacity is not recommended in patients with known structural abnormalities of the lungs or chronic obstructive airway disease. We report the case of a 72-year-old woman who had poliomyelitis as a child, developed torsion scoliosis and post-polio syndrome, and had periodic but infrequent asthma attacks. After performing air stacking for 3 years, the patient suddenly developed a pneumothorax, indicating that this technique should be used with caution or not at all in patients with a known pulmonary pathology

  1. The Impact of Oil Price Changes on Inflation in Pakistan

    OpenAIRE

    Malik, Afia

    2016-01-01

    Oil prices have fluctuated enormously in recent years. Strong volatility in oil prices has serious implications for Pakistan’s economy given its substantial dependence on imported fuels. Energy prices have a crucial role behind inflation rates in Pakistan and it is proved in this study. We estimate the effects of oil price changes on inflation for Pakistan using an augmented Phillips curve framework. Our results suggest a strong oil price-inflation relationship, especially when oil prices are...

  2. Inflation in the Costs of Building Aircraft Carriers

    Science.gov (United States)

    2016-04-01

    amount the Navy could spend on the second and following ships in the Ford class. That amount could be adjusted to account for economic inflation and...other factors. (The legislation did not clearly define “economic inflation ,” but the Navy has interpreted it to mean increases in the prices of...Actual inflation in the prices of labor and materials was the most important contributor to the rise in the cost cap, accounting for $2.5 billion of the

  3. CIBLAGE D'INFLATION ET CONDUITE DE LA POLITIQUE ...

    African Journals Online (AJOL)

    Administrateur

    RÉSUMÉ. Le ciblage d'inflation constitue le développement le plus impor- tant en matière de politique monétaire durant les vingt-cinq dernières années. La stabilisation de l'inflation à des niveaux bas constitue le premier objectif ultime de la politique monétaire dans le cadre de cette stratégie du ciblage d'inflation.

  4. Inflation and Productivity in the United Kingdom: An Empirical Note

    OpenAIRE

    Peter J. Saunders; Biswas, Basudeb

    1987-01-01

    The escalating inflation in the second part of the 1970s and the early 1980s has revived interest in the theoretical relationship between inflation and the growth of productivity. The standard theoretical view maintains that the unidirectional flow of causality runs from productivity changes to inflation. It assumes that productivity growth is exogenous, and that positive productivity growth is anti-inflationary because it increases the economy's aggregate supply, which in turn offsets the in...

  5. Lung density

    DEFF Research Database (Denmark)

    Garnett, E S; Webber, C E; Coates, G

    1977-01-01

    The density of a defined volume of the human lung can be measured in vivo by a new noninvasive technique. A beam of gamma-rays is directed at the lung and, by measuring the scattered gamma-rays, lung density is calculated. The density in the lower lobe of the right lung in normal man during quiet...... breathing in the sitting position ranged from 0.25 to 0.37 g.cm-3. Subnormal values were found in patients with emphsema. In patients with pulmonary congestion and edema, lung density values ranged from 0.33 to 0.93 g.cm-3. The lung density measurement correlated well with the findings in chest radiographs...... but the lung density values were more sensitive indices. This was particularly evident in serial observations of individual patients....

  6. Portfolio Management with Stochastic Interest Rates and Inflation Ambiguity

    DEFF Research Database (Denmark)

    Munk, Claus; Rubtsov, Alexey Vladimirovich

    -Jacobi-Bellman equation in closed form and derive and illustrate a number of interesting properties of the solution. For example, ambiguity aversion affects the optimal portfolio through the correlation of price level with the stock index, a bond, and the expected inflation rate. Furthermore, unlike other settings......We solve a stock-bond-cash portfolio choice problem for a risk- and ambiguity-averse investor in a setting where the inflation rate and interest rates are stochastic. The expected inflation rate is unobservable, but the investor may learn about it from realized inflation and observed stock and bond...

  7. Phase transition and monopole production in supergravity inflation

    Energy Technology Data Exchange (ETDEWEB)

    Kamada, Kohei [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Nakayama, Kazunori [Tokyo Univ. (Japan). Dept. of Physics; Yokoyama, Jun' ichi [Tokyo Univ. (Japan). Research Center for the Early Universe; Tokyo Univ. (JP). Inst. for the Physics and Mathematics of the Universe (IPMU)

    2011-10-15

    In F-term supergravity inflation models, scalar fields other than the inflaton generically receive a Hubble induced mass, which may restore gauge symmetries during inflation and phase transitions may occur during or after inflation as the Hubble parameter decreases. We study monopole (and domain wall) production associated with such a phase transition in chaotic inflation in supergravity and obtain a severe constraint on the symmetry breaking scale which is related with the tensor-to-scalar ratio. Depending on model parameters, it is possible that monopoles are sufficiently diluted to be free from current constraints but still observable by planned experiments. (orig.)

  8. Heterogeneity, learning and information stickiness in inflation expectations

    DEFF Research Database (Denmark)

    Pfajfar, Damjan; Santoro, Emiliano

    2010-01-01

    In this paper we propose novel techniques for the empirical analysis of adaptive learning and sticky information in inflation expectations. These methodologies are applied to the distribution of households’ inflation expectations collected by the University of Michigan Survey Research Center....... To account for the evolution of the cross-section of inflation forecasts over time and measure the degree of heterogeneity in private agents’ forecasts, we explore time series of percentiles from the empirical distribution. Our results show that heterogeneity is pervasive in the process of inflation...

  9. Combining high-scale inflation with low-energy SUSY

    Energy Technology Data Exchange (ETDEWEB)

    Antusch, Stefan [Basel Univ. (Switzerland). Dept. of Physics; Max-Planck-Institut fuer Physik, Muenchen (Germany). Werner-Heisenberg-Institut; Dutta, Koushik [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Halter, Sebastian [Max-Planck-Institut fuer Physik, Muenchen (Germany). Werner-Heisenberg-Institut

    2011-12-15

    We propose a general scenario for moduli stabilization where low-energy supersymmetry can be accommodated with a high scale of inflation. The key ingredient is that the stabilization of the modulus field during and after inflation is not associated with a single, common scale, but relies on two different mechanisms. We illustrate this general scenario in a simple example, where during inflation the modulus is stabilized with a large mass by a Kaehler potential coupling to the field which provides the inflationary vacuum energy via its F-term. After inflation, the modulus is stabilized, for instance, by a KKLT superpotential. (orig.)

  10. Supersymmetric moduli stabilization and high-scale inflation

    Directory of Open Access Journals (Sweden)

    Wilfried Buchmuller

    2014-09-01

    Full Text Available We study the back-reaction of moduli fields on the inflaton potential in generic models of F-term inflation. We derive the moduli corrections as a power series in the ratio of Hubble scale and modulus mass. The general result is illustrated with two examples, hybrid inflation and chaotic inflation. We find that in both cases the decoupling of moduli dynamics and inflation requires moduli masses close to the scale of grand unification. For smaller moduli masses the CMB observables are strongly affected.

  11. Replenishment policy for an inventory model under inflation

    Science.gov (United States)

    Singh, Vikramjeet; Saxena, Seema; Singh, Pushpinder; Mishra, Nitin Kumar

    2017-07-01

    The purpose of replenishment is to keep the flow of inventory in the system. To determine an optimal replenishment policy is a great challenge in developing an inventory model. Inflation is defined as the rate at which the prices of goods and services are rising over a time period. The cost parameters are affected by the rate of inflation. High rate of inflation affects the organizations financial conditions. Based on the above backdrop the present paper proposes the retailers replenishment policy for deteriorating items with different cycle lengths under inflation. The shortages are partially backlogged. At last numerical examples validate the results.

  12. What Is Lung Cancer?

    Science.gov (United States)

    ... Shareable Graphics Infographics “African-American Men and Lung Cancer” “Lung Cancer Is the Biggest Cancer Killer in Both ... starts in the lungs, it is called lung cancer. Lung cancer begins in the lungs and may spread ...

  13. The Effects Of Asymmetric Transmission Of Exchange Rate On Inflation In Iran: Application Of Threshold Models

    Directory of Open Access Journals (Sweden)

    Naghdi Yazdan

    2015-08-01

    Full Text Available Given the recent fluctuation in the exchange rate and the presence of several factors such as the various economy-political sanctions (mainly embargos on oil and banking, extreme volatility in different economic fields, and consequently the devaluation of national and public procurement -A landmark that is emanating from exchange rate fluctuation - two points should be noted: First, it is essential to review the effect of exchange rate fluctuation on macro economic variables such as inflation and to provide appropriate policies. Second, the existence of this condition provides the chance to study the relation between exchange rate and inflation in a non-linear and asymmetric method. Hence, the present study seeks to use TAR model and, on the basis of monthly time series data over the period March 2002 to March 2014, to analyze the cross-asymmetric and non-linear exchange rate on consumer price index (CPI in Iran. The results also show the presence of an asymmetric long-term relationship between these variables (exchange rate and CPI. Also, in the Iranian economy, the effect of negative shocks of exchange rate on inflation is more sustainable than the one from positive shocks.

  14. Statistical evaluation of the degree of nominal convergence of the inflation rate in Romania

    Directory of Open Access Journals (Sweden)

    Mihai GHEORGHE

    2011-07-01

    Full Text Available Nominal convergence is a process that is characterised by the gradual harmonisation, to a relatively high degree, of the national institutions and policies of the Member States with those of the EU, in the monetary and financial fields.The birth of nominal convergence is marked by the Maastricht Treaty, by means of which the criteria required for adopting the euro were established. One of the criteria refers to price stability (inflation rate, which is measured by the Harmonised Index of Consumer Prices. A Member State meets this criterion if it has a price performance that is sustainable and an average rate of inflation, observed over a period of one year before the examination,that does not exceed by more than 1.5 percentage point that of, at most, the three best performing Member States in terms of price stability.The article proposes a model for the statistical evaluation of the degree to which the nominal convergence criterion related to price stability is met. The evaluation is based on the following pillars: a theoretical synthesis of the Harmonised Index of Consumer Prices, a statistical analysis concerning the evolution of inflation in Romania and the gap vis-à-vis the reference value for meeting the nominal convergence criterion.

  15. Unification of inflation and dark energy {\\it \\`a la} quintessential inflation

    CERN Document Server

    Hossain, Md Wali; Sami, M; Saridakis, Emmanuel N

    2014-01-01

    This pedagogical review is devoted to quintessential inflation, which refers to unification of inflation and dark energy using a single scalar field. We present a brief but concise description of the concepts needed to join the two ends, which include discussion on scalar field dynamic, conformal coupling, instant preheating and relic gravitational waves. Models of quintessential inflation broadly fall into two classes, depending upon the early and late time behavior of the field potential. In the first type we include models in which the field potential is steep for most of the history of the Universe but turn shallow at late times, whereas in the second type the potential is shallow at early times followed by a steep behavior thereafter. In models of the first category inflation can be realized by invoking high-energy brane-induced damping, which is needed to facilitate slow roll along a steep potential. In models of second type one may invoke a non-minimal coupling of the scalar field with massive neutrino...

  16. THE INFLATION IMPACT OF SELECTED EUROPEAN UNION MEMBERS ON POLISH INFLATION

    Directory of Open Access Journals (Sweden)

    Jarosław Czaja

    2012-06-01

    Full Text Available The article aims at determining the inflation influence between Poland and selected EU member states. Although for some time the general inflation level in those countries was definitely controllable, the problem seems to be returning. That is why in this article, using the model of Vector AutoRegression (VAR and Granger causality test, we are attempting to determine inflation influences on Poland. The study confirmed the impact of the selected countries on Polish inflation, expressed the general HICP index. However, in the case of Germany, the method has not proved the existence of such interactions. For this reason, it is made an attempt to clarify the reasons for non-compliance findings with data showing Germany as a Polish main trading partner for more than two decades. The authors try to show that lack of influence can be seen in the excessive generality of the main HICP index and predict that the chosen method confirm the effect of foreign trade indices in the HICP.

  17. Does inequality cause inflation? The political economy of inflation, taxation and government debt

    NARCIS (Netherlands)

    Beetsma, R.M.W.J.; van der Ploeg, F.

    1992-01-01

    A democratic society in which the distribution of wealth is unequal elects political parties which tend to represent the interests of the poor. The clientele of such governments favor unanticipated inflation taxes to erode the real value of debt service and redistribute income from the rich to the

  18. Inflation in the universe and time asymmetry

    Energy Technology Data Exchange (ETDEWEB)

    Davies, P.C.W. (Newcastle upon Tyne Univ. (UK). Dept. of Theoretical Physics)

    1984-12-06

    The author previously argued that the origin of time asymmetry is to be sought in the processes that characterized the very early cosmological epochs, and that the recent inflationary scenario provides a crucial element in our understanding of this origin. Here this theses is developed in the light of recent criticisms. The author argues in particular that any of the ''initial states'' appear to be permitted by quantum gravity, if succeeded by a period of inflation, would have wound up the universe to the state from which, as indicated by increasing entropy, it is now winding down.

  19. f( R) constant-roll inflation

    Science.gov (United States)

    Motohashi, Hayato; Starobinsky, Alexei A.

    2017-08-01

    The previously introduced class of two-parametric phenomenological inflationary models in general relativity in which the slow-roll assumption is replaced by the more general, constant-roll condition is generalized to the case of f( R) gravity. A simple constant-roll condition is defined in the original Jordan frame, and exact expressions for a scalaron potential in the Einstein frame, for a function f( R) (in the parametric form) and for inflationary dynamics are obtained. The region of the model parameters permitted by the latest observational constraints on the scalar spectral index and the tensor-to-scalar ratio of primordial metric perturbations generated during inflation is determined.

  20. Inflation and the quantum measurement problem

    Science.gov (United States)

    Alexander, Stephon; Jyoti, Dhrubo; Magueijo, João

    2016-08-01

    We propose a solution to the quantum measurement problem in inflation. Our model treats Fourier modes of cosmological perturbations as analogous to particles in a weakly interacting Bose gas. We generalize the idea of a macroscopic wave function to cosmological fields, and construct a self-interaction Hamiltonian that focuses that wave function. By appropriately setting the coupling between modes, we obtain the standard adiabatic, scale-invariant power spectrum. Because of central limit theorem, we recover a Gaussian random field, consistent with observations.