Sample records for sustained growth cone

  1. Mechanochemical regulation of growth cone motility

    Directory of Open Access Journals (Sweden)

    Patrick C Kerstein


    Full Text Available Neuronal growth cones are exquisite sensory-motor machines capable of transducing features contacted in their local extracellular environment into guided process extension during development. Extensive research has shown that chemical ligands activate cell surface receptors on growth cones leading to intracellular signals that direct cytoskeletal changes. However, the environment also provides mechanical support for growth cone adhesion and traction forces that stabilize leading edge protrusions. Interestingly, recent work suggests that both the mechanical properties of the environment and mechanical forces generated within growth cones influence axon guidance. In this review we discuss novel molecular mechanisms involved in growth cone force production and detection, and speculate how these processes may be necessary for the development of proper neuronal morphogenesis.

  2. The Sustainability Cone - A holistic framework to integrate sustainability thinking into manufacturing

    DEFF Research Database (Denmark)

    Rödger, Jan-Markus; Bey, Niki; Alting, Leo


    Integrating sustainability into manufacturing is a multifaceted endeavour. Global sustainability aspects and specific manufacturing success factors have to be combined with life cycle thinking in order to get the holistic view on manufacturing which is needed to make truly sustainability-oriented...... thinking, as essential part of the Sustainability Cone, derived from customer-demanded functionality down to a production system.......Integrating sustainability into manufacturing is a multifaceted endeavour. Global sustainability aspects and specific manufacturing success factors have to be combined with life cycle thinking in order to get the holistic view on manufacturing which is needed to make truly sustainability...

  3. Syndecan Promotes Axon Regeneration by Stabilizing Growth Cone Migration

    Directory of Open Access Journals (Sweden)

    Tyson J. Edwards


    Full Text Available Growth cones facilitate the repair of nervous system damage by providing the driving force for axon regeneration. Using single-neuron laser axotomy and in vivo time-lapse imaging, we show that syndecan, a heparan sulfate (HS proteoglycan, is required for growth cone function during axon regeneration in C. elegans. In the absence of syndecan, regenerating growth cones form but are unstable and collapse, decreasing the effective growth rate and impeding regrowth to target cells. We provide evidence that syndecan has two distinct functions during axon regeneration: (1 a canonical function in axon guidance that requires expression outside the nervous system and depends on HS chains and (2 an intrinsic function in growth cone stabilization that is mediated by the syndecan core protein, independently of HS. Thus, syndecan is a regulator of a critical choke point in nervous system repair.

  4. Modulation of growth cone filopodial length by carbon monoxide. (United States)

    Estes, Stephen; Artinian, Liana; Rehder, Vincent


    Carbon monoxide (CO) is physiologically produced via heme degradation by heme oxygenase enzymes. Whereas CO has been identified as an important physiological signaling molecule, the roles it plays in neuronal development and regeneration are poorly understood. During these events, growth cones guide axons through a rich cellular environment to locate target cells and establish synaptic connections. Previously, we have shown that another gaseous signaling molecule, nitric oxide (NO), has potent effects on growth cone motility. With NO and CO sharing similar cellular targets, we wanted to determine whether CO affected growth cone motility as well. We assessed how CO affected growth cone filopodial length and determined the signaling pathway by which this effect was mediated. Using two well-characterized neurons from the freshwater snail, Helisoma trivolvis, it was found that the CO donor, carbon monoxide releasing molecule-2 (CORM-2), increased filopodial length. CO utilized a signaling pathway that involved the activation of soluble guanylyl cyclase, protein kinase G, and ryanodine receptors. While increases in filopodial length often occur from robust increases in intracellular calcium levels, the timing in which CO increased filopodial length corresponded with low basal calcium levels in growth cones. Taken together with findings of a heme oxygenase-like protein in the Helisoma nervous system, these results provide evidence for CO as a modulator of growth cone motility and implicate CO as a neuromodulatory signal during neuronal development and/or regeneration. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 677-690, 2017. © 2016 Wiley Periodicals, Inc.

  5. Fast regulation of axonal growth cone motility by electrical activity. (United States)

    Ibarretxe, Gaskon; Perrais, David; Jaskolski, Frédéric; Vimeney, Alice; Mulle, Christophe


    Axonal growth cones are responsible for the correct guidance of developing axons and the establishment of functional neural networks. They are highly motile because of fast and continuous rearrangements of their actin-rich cytoskeleton. Here we have used live imaging of axonal growth cones of hippocampal neurons in culture and quantified their motility with a temporal resolution of 2 s. Using novel methods of analysis of growth cone dynamics, we show that transient activation of kainate receptors by bath-applied kainate induced a fast and reversible growth cone stalling. This effect depends on electrical activity and can be mimicked by the transient discharge of action potentials elicited in the neuron by intracellular current injections at the somatic level through a patch pipette. Growth cone stalling induced by electrical stimulation is mediated by calcium entry from the extracellular medium as well as by calcium release from intracellular stores that define spatially restricted microdomains directly affecting cytoskeletal dynamics. We propose that growth cone motility is dynamically controlled by transient bursts of spontaneous electrical activity, which constitutes a prominent feature of developing neural networks in vivo.

  6. Functional complexity of the axonal growth cone: a proteomic analysis.

    Directory of Open Access Journals (Sweden)

    Adriana Estrada-Bernal

    Full Text Available The growth cone, the tip of the emerging neurite, plays a crucial role in establishing the wiring of the developing nervous system. We performed an extensive proteomic analysis of axonal growth cones isolated from the brains of fetal Sprague-Dawley rats. Approximately 2000 proteins were identified at ≥ 99% confidence level. Using informatics, including functional annotation cluster and KEGG pathway analysis, we found great diversity of proteins involved in axonal pathfinding, cytoskeletal remodeling, vesicular traffic and carbohydrate metabolism, as expected. We also found a large and complex array of proteins involved in translation, protein folding, posttranslational processing, and proteasome/ubiquitination-dependent degradation. Immunofluorescence studies performed on hippocampal neurons in culture confirmed the presence in the axonal growth cone of proteins representative of these processes. These analyses also provide evidence for rough endoplasmic reticulum and reveal a reticular structure equipped with Golgi-like functions in the axonal growth cone. Furthermore, Western blot revealed the growth cone enrichment, relative to fetal brain homogenate, of some of the proteins involved in protein synthesis, folding and catabolism. Our study provides a resource for further research and amplifies the relatively recently developed concept that the axonal growth cone is equipped with proteins capable of performing a highly diverse range of functions.

  7. Axonal branching and growth cone structure depend on target cells. (United States)

    Berman, S A; Moss, D; Bursztajn, S


    Growth cones provide crucial guidance to neurons in response to appropriate targets and other environmental cues. We have cocultured ciliary neurons with myotubes and utilized antibodies to GAP-43 (a neuron-specific, growth-associated phosphoprotein) and MAP-2 (a cytoskeletal marker for dendrites) together with immunofluorescence microscopy to characterize the changes in patterns and polarity that ciliary nerve growth cones undergo when they contact a "proper" target. Our results show that ciliary neurons plated alone or cocultured with fibroblasts have one or two axons, but, when cocultured with myotubes, most cells have 4 or 5 axons showing GAP-43 immunoreactivity. The mean number of axons per cell soma was 1.9 +/- 0.9 micron2 (SEM) when ciliary neurons were plated alone and 3.4 +/- 0.1 when ciliary neurons were cocultured with myotubes. Differences in growth cone size were readily apparent in these two types of cultures. In coculture with myotubes the neuronal growth cone lamelopodia occupied 20-30 microns2 with an average area of 25.0 +/- 2.3 microns2 (SEM) whereas those neurons plated alone or in the presence of fibroblasts occupied an average area of 56.3 microns2 +/- 4.1 microns2 (SEM). The number of growth cone filopodia depended on culture condition. In nerve-muscle cocultures, the average number of filopodia per growth cone was 3.6 +/- 0.2 (SEM), whereas in ciliary cultures plated in the absence of myotubes the number of filopodia was 6.8 +/- 0.4 (SEM). These results indicate that muscle cells or the factors they release can regulate the growth and topography of axons and their growth cones.

  8. Homer regulates calcium signalling in growth cone turning

    Directory of Open Access Journals (Sweden)

    Thompson Michael JW


    Full Text Available Abstract Background Homer proteins are post-synaptic density proteins with known functions in receptor trafficking and calcium homeostasis. While they are key mediators of synaptic plasticity, they are also known to function in axon guidance, albeit by mechanisms that are yet to be elucidated. Homer proteins couple extracellular receptors – such as metabotropic glutamate receptors and the transient receptor potential canonical family of cation channels – to intracellular receptors such as inositol triphosphate and ryanodine receptors on intracellular calcium stores and, therefore, are well placed to regulate calcium dynamics within the neural growth cone. Here we used growth cones from dorsal root ganglia, a well established model in the field of axon guidance, and a growth cone turning assay to examine Homer1 function in axon guidance. Results Homer1 knockdown reversed growth cone turning from attraction to repulsion in response to the calcium-dependent guidance cues brain derived neurotrophic factor and netrin-1. Conversely, Homer1 knockdown had no effect on repulsion to the calcium-independent guidance cue Semaphorin-3A. This reversal of attractive turning suggested a requirement for Homer1 in a molecular switch. Pharmacological experiments confirmed that the operational state of a calcium-calmodulin dependent protein kinase II/calcineurin phosphatase molecular switch was dependent on Homer1 expression. Calcium imaging of motile growth cones revealed that Homer1 is required for guidance-cue-induced rise of cytosolic calcium and the attenuation of spontaneous cytosolic calcium transients. Homer1 knockdown-induced calcium transients and turning were inhibited by antagonists of store-operated channels. In addition, immunocytochemistry revealed the close association of Homer1 with the store-operated proteins TRPC1 and STIM1 within dorsal root ganglia growth cones. Conclusion These experiments provide evidence that Homer1 is an essential

  9. The Sustainability Cone - A holistic framework to integrate sustainability thinking into manufacturing

    DEFF Research Database (Denmark)

    Rödger, Jan-Markus; Bey, Niki; Alting, Leo


    -oriented decisions in manufacturing. Industry, at the same time, is always deterred by possible high cost and time constraints related to implementing new approaches. Using examples from car manufacturing, this paper introduces and explains a new sustainable manufacturing framework - the Sustainability Cone......Integrating sustainability into manufacturing is a multifaceted endeavour. Global sustainability aspects and specific manufacturing success factors have to be combined with life cycle thinking in order to get the holistic view on manufacturing which is needed to make truly sustainability...... - as the missing link which closes these gaps by providing necessary holistic and consistent overview while being aligned with established stage-gate project execution models, thus ensuring practical applicability as shown for a highly automated production cell. The paper shows how to apply life cycle target...

  10. Role of laminin and integrin interactions in growth cone guidance. (United States)

    McKerracher, L; Chamoux, M; Arregui, C O


    Laminin is well known to promote neuronal adhesion and axonal growth, but recent experiments suggest laminin has a wider role in guiding axons, both in development and regeneration. In vitro experiments demonstrate that laminin can alter the rate and direction of axonal growth, even when growth cone contact with laminin is transient. Investigations focused on a single neuronal type, such as retinal ganglion cells (RGCs), strongly implicate laminin as an important guidance molecule in development and suggest the involvement of integrins. Integrins are receptors for laminin, and neurons express multiple types of integrins that bind laminin. Morphologically, integrins cluster in point contacts, specialized regions of the growth cone that may coordinately regulate adhesion and motility. Recent evidence suggests that the structure and regulation of point contacts may differ from that of their nonneuronal counterpart, focal contacts. In part, this may be because the interaction of the cytoplasmic domain of integrin with the cytoskeleton is different in point contacts and focal contracts. Mutational studies where the cytoplasmic domain is truncated or altered are leading to a better understanding of the role of the alpha and beta subunit in regulating integrin clustering and binding to the cytoskeleton. In addition, whereas integrins may regulate motility through direct physical linkages to the growth cone cytoskeleton, an equally important role is their ability to elicit signaling, both through protein tyrosine phosphorylation and modulating calcium levels. Through such mechanisms integrins likely regulate the dynamic attachment and detachment of the growth cone as it moves on laminin substrates.

  11. Variability and Reliabiltiy in Axon Growth Cone Navigation Decision Making (United States)

    Garnelo, Marta; Ricoult, Sébastien G.; Juncker, David; Kennedy, Timothy E.; Faisal, Aldo A.


    The nervous system's wiring is a result of axon growth cones navigating through specific molecular environments during development. In order to reach their target, growth cones need to make decisions under uncertainty as they are faced with stochastic sensory information and probabilistic movements. The overall system therefore exhibits features of whole organisms (perception, decision making, action) in the subset of a single cell. We aim to characterise growth cone navigation in defined nano-dot guidance cue environments, by using the tools of computational neuroscience to conduct ``molecular psychophysics.'' We start with a generative model of growth cone behaviour and we 1. characterise sensory and internal sources of noise contributing to behavioural variables, by combining knowledge of the underlying stochastic dynamics in cue sensing and the growth of the cytoskeleton. This enables us to 2. produce bottom-up lower limit estimates of behavioural response reliability and visualise it as probability distributions over axon growth trajectories. Given this information we can match our in silico model's ``psychometric'' decision curves with empirical data. Finally we use a Monte-Carlo approach to predict response distributions of axon trajectories from our model.

  12. Adenosine induces growth-cone turning of sensory neurons. (United States)

    Grau, Benjamin; Eilert, John-Christian; Munck, Sebastian; Harz, Hartmann


    The formation of appropriate connections between neurons and their specific targets is an essential step during development and repair of the nervous system. Growth cones are located at the leading edges of the growing neurites and respond to environmental cues in order to be guided to their final targets. Directional information can be coded by concentration gradients of substrate-bound or diffusible-guidance molecules. Here we show that concentration gradients of adenosine stimulate growth cones of sensory neurons (dorsal root ganglia) from chicken embryos to turn towards the adenosine source. This response is mediated by adenosine receptors. The subsequent signal transduction process involves cAMP. It may be speculated that the in vivo function of this response is concerned with the formation or the repair and regeneration of the peripheral nervous system.

  13. Towards Sustainable Growth Business Models

    Energy Technology Data Exchange (ETDEWEB)

    Kamp-Roelands, N.; Balkenende, J.P.; Van Ommen, P.


    The Dutch Sustainable Growth Coalition (DSGC) has the following objectives: The DSGC aims to pro-actively drive sustainable growth business models along three lines: (1) Shape. DSGC member companies aim to connect economic profitability with environmental and social progress on the basis of integrated sustainable growth business models; (2) Share. DSGC member companies aim for joint advocacy of sustainable growth business models both internationally and nationally; and (3) Stimulate. DSGC member companies aim to stimulate and influence the policy debate on enabling sustainable growth - with a view to finding solutions to the environmental and social challenges we are facing. This is their first report. The vision, actions and mission of DSGC are documented in the Manifesto in Chapter 2 of this publication. Chapter 3 contains an overview of key features of an integrated sustainable growth business model and the roadmap towards such a model. In Chapter 4, project examples of DSGC members are presented, providing insight into the hands-on reality of implementing the good practices. Chapter 5 offers an overview of how the Netherlands provides an enabling environment for sustainable growth business models. Chapter 6 offers the key conclusions.

  14. Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1 (United States)

    Marsick, Bonnie M.; Flynn, Kevin C.; Santiago-Medina, Miguel; Bamburg, James R.; Letourneau, Paul C.


    Proper neural circuitry requires that growth cones, motile tips of extending axons, respond to molecular guidance cues expressed in the developing organism. However, it is unclear how guidance cues modify the cytoskeleton to guide growth cone pathfinding. Here we show acute treatment with two attractive guidance cues, nerve growth factor (NGF) and netrin-1, for embryonic dorsal root ganglion and temporal retinal neurons, respectively, results in increased growth cone membrane protrusion, actin polymerization, and filamentous actin (F-actin). ADF/cofilin (AC) family proteins facilitate F-actin dynamics, and we found the inactive phosphorylated form of AC is decreased in NGF- or netrin-1-treated growth cones. Directly increasing AC activity mimics addition of NGF or netrin-1 to increase growth cone protrusion and F-actin levels. Extracellular gradients of NGF, netrin-1, and a cell-permeable AC elicit attractive growth cone turning and increased F-actin barbed ends, F-actin accumulation, and active AC in growth cone regions proximal to the gradient source. Reducing AC activity blunts turning responses to NGF and netrin. Our results suggest that gradients of NGF and netrin-1 locally activate AC to promote actin polymerization and subsequent growth cone turning toward the side containing higher AC activity. PMID:20506164

  15. Sustainability, Smart Growth, and Landscape Architecture (United States)

    Sustainability, Smart Growth, and Landscape Architecture is an overview course for landscape architecture students interested in sustainability in landscape architecture and how it might apply to smart growth principles in urban, suburban, and rural areas

  16. Syntaxin 1B suppresses macropinocytosis and semaphorin 3A-induced growth cone collapse. (United States)

    Kabayama, Hiroyuki; Takeuchi, Makoto; Taniguchi, Masahiko; Tokushige, Naoko; Kozaki, Shunji; Mizutani, Akihiro; Nakamura, Takeshi; Mikoshiba, Katsuhiko


    Growth cone collapse is a crucial process for repulsive axon guidance and is accompanied by a reduction in growth cone surface area. This process of reduction may be regulated by endocytosis; however, its molecular mechanism is unclear. Macropinocytosis is a clathrin-independent form of endocytosis in which large areas of plasma membrane can be engulfed. We have reported previously that macropinocytosis is induced in growth cones of chick dorsal root ganglion neurons by semaphorin 3A (Sema3A), a repulsive axon guidance cue, and that Sema3A-induced reduction in growth cone surface area and macropinocytic vacuole area were correlated, suggesting a positive role for macropinocytosis in Sema3A-induced growth cone collapse. In the present study, we found that syntaxin 1B (Syx1B), a membrane trafficking protein, is a negative regulator of macropinocytosis, and its expression is downregulated by Sema3A signaling. Macropinocytosis inhibitor ethylisopropylamiloride or Syx1B overexpression suppressed Sema3A-induced macropinocytosis and growth cone collapse. These results indicate that Syx1B couples macropinocytosis-mediated massive internalization of the plasma membrane to Sema3A-induced growth cone collapse.

  17. Cone production, seed dispersal, germination in...old-growth redwood cut and uncut stands (United States)

    Kenneth N. Boe


    Records of 5 and 6 years' cone crops in old-growth redwood (Sequoia sempervirens [D. Don Endl.] stands in northern California were studied for silvical facts. They show that (a) the principal trees in both cut and uncut stands bore fair to good cone crops for 5 consecutive years, (b) maximum seed dispersal of both total and sound seed occurred in winter, (c)...

  18. Growth Cone Travel in Space and Time: the Cellular Ensemble of Cytoskeleton, Adhesion, and Membrane

    National Research Council Canada - National Science Library

    Vitriol, Eric A; Zheng, James Q


    Growth cones, found at the tip of axonal projections, are the sensory and motile organelles of developing neurons that enable axon pathfinding and target recognition for precise wiring of the neural circuitry...

  19. Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane. (United States)

    Vitriol, Eric A; Zheng, James Q


    Growth cones, found at the tip of axonal projections, are the sensory and motile organelles of developing neurons that enable axon pathfinding and target recognition for precise wiring of the neural circuitry. To date, many families of conserved guidance molecules and their corresponding receptors have been identified that work in space and time to ensure billions of axons to reach their targets. Research in the past two decades has also gained significant insight into the ways in which growth cones translate extracellular signals into directional migration. This review aims to examine new progress toward understanding the cellular mechanisms underlying directional motility of the growth cone and to discuss questions that remain to be addressed. Specifically, we will focus on the cellular ensemble of cytoskeleton, adhesion, and membrane and examine how the intricate interplay between these processes orchestrates the directed movement of growth cones. Copyright © 2012 Elsevier Inc. All rights reserved.

  20. Integrin-linked kinase regulates oligodendrocyte cytoskeleton, growth cone, and adhesion dynamics. (United States)

    Michalski, John-Paul; Cummings, Sarah E; O'Meara, Ryan W; Kothary, Rashmi


    Integrin-linked kinase (ILK), a focal adhesion protein, brokers the link between cytoskeleton, cell membrane, and extracellular environment. Here, we demonstrate a role for ILK in laminin-2-mediated adhesion in primary murine oligodendrocytes (OLs) - with ILK loss leading to severe defects in process branching and outgrowth. These defects were partially recovered when the ILK-depleted OLs were instead grown on the non-integrin-activating substrate poly-l-lysine. Intriguingly, ILK loss on the neutral poly-l-lysine substrate led to swelling at the tips of OL processes, which we identified as enlarged growth cones. Employing the bloated ILK-depleted growth cones as template, we demonstrate the appearance of distinct cytoskeletal domains within OL growth cones bearing classic neuronal growth cone architecture. Further, microtubule organization was severely perturbed following ILK loss, with centripetal microtubule looping and failure to bundle occurring in a laminin-2-independent manner. Together, our work highlights differences in specific aspects of OL biology as driven by laminin-2-dependent or independent ILK governed mechanisms. We also reinforce the idea of OLs as growth cone bearing cells and describe the neuronal-like cytoskeleton therein. Finally, we demonstrate a role for ILK in OL growth cone maturation through microtubule regulation, the loss of which translates to decreased process length and myelin production capacity. We describe herein how different substrates fundamentally alter the oligodendrocyte's response to loss of integrin-linked kinase (ILK). On laminin-2 (Ln-2), ILK-depleted oligodendrocytes appear stunted and malformed, while on the non-integrin-activating substrate PLL branching and membrane formation are restored. We also reinforce the idea of oligodendrocytes as growth cone-bearing cells, detailing the growth cone's cytoskeletal architecture. Strikingly, loss of ILK on poly-l-lysine leads to growth cone swelling, the structure's size and

  1. Nano-scale Topographical Studies on the Growth Cones of Nerve Cells using AFM (United States)

    Durkaya, Goksel; Zhong, Lei; Rehder, Vincent; Dietz, Nikolaus


    Nerve cells are the fundamental units which are responsible for intercommunication within the nervous system. The neurites, fibrous cable-like extensions for information delivery, of nerve cells are tipped by highly motile sensory structures known as the growth cones which execute important functions; neural construction, decision making and navigation during development and regeneration of the nervous system. The highly dynamic subcomponents of the growth cones are important in neural activity. Atomic Force Microscopy (AFM) is the most powerful microscopy technique which is capable of imaging without conductivity constraint and in liquid media. AFM providing nano-scale topographical information on biological structures is also informative on the physical properties such as: elasticity, adhesion, and softness. This contribution focuses on AFM analysis of the growth cones of the nerve cells removed from the buccal ganglion of Helisoma trivolvis. The results of nano-scale topography and softness analysis on growth cone central domain, filopodia and overlying lamellopodium (veil) are presented. The subcomponents of the growth cones of different nerve cells are compared to each other. The results of the analysis are linked to the mechanical properties and internal molecular density distribution of the growth cones.

  2. Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis. (United States)

    Tojima, Takuro; Itofusa, Rurika; Kamiguchi, Hiroyuki


    Extracellular molecular cues guide migrating growth cones along specific routes during development of axon tracts. Such processes rely on asymmetric elevation of cytosolic Ca(2+) concentrations across the growth cone that mediates its attractive or repulsive turning toward or away from the side with Ca(2+) elevation, respectively. Downstream of these Ca(2+) signals, localized activation of membrane trafficking steers the growth cone bidirectionally, with endocytosis driving repulsion and exocytosis causing attraction. However, it remains unclear how Ca(2+) can differentially regulate these opposite membrane-trafficking events. Here, we show that growth cone turning depends on localized imbalance between exocytosis and endocytosis and identify Ca(2+)-dependent signaling pathways mediating such imbalance. In embryonic chicken dorsal root ganglion neurons, repulsive Ca(2+) signals promote clathrin-mediated endocytosis through a 90 kDa splice variant of phosphatidylinositol-4-phosphate 5-kinase type-1γ (PIPKIγ90). In contrast, attractive Ca(2+) signals facilitate exocytosis but suppress endocytosis via Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (Cdk5) that can inactivate PIPKIγ90. Blocking CaMKII or Cdk5 leads to balanced activation of both exocytosis and endocytosis that causes straight growth cone migration even in the presence of guidance signals, whereas experimentally perturbing the balance restores the growth cone's turning response. Remarkably, the direction of this resumed turning depends on relative activities of exocytosis and endocytosis, but not on the type of guidance signals. Our results suggest that navigating growth cones can be redirected by shifting the imbalance between exocytosis and endocytosis, highlighting the importance of membrane-trafficking imbalance for axon guidance and, possibly, for polarized cell migration in general. Copyright © 2014 the authors 0270-6474/14/347165-14$15.00/0.

  3. Multi-phasic bi-directional chemotactic responses of the growth cone (United States)

    Naoki, Honda; Nishiyama, Makoto; Togashi, Kazunobu; Igarashi, Yasunobu; Hong, Kyonsoo; Ishii, Shin


    The nerve growth cone is bi-directionally attracted and repelled by the same cue molecules depending on the situations, while other non-neural chemotactic cells usually show uni-directional attraction or repulsion toward their specific cue molecules. However, how the growth cone differs from other non-neural cells remains unclear. Toward this question, we developed a theory for describing chemotactic response based on a mathematical model of intracellular signaling of activator and inhibitor. Our theory was first able to clarify the conditions of attraction and repulsion, which are determined by balance between activator and inhibitor, and the conditions of uni- and bi-directional responses, which are determined by dose-response profiles of activator and inhibitor to the guidance cue. With biologically realistic sigmoidal dose-responses, our model predicted tri-phasic turning response depending on intracellular Ca2+ level, which was then experimentally confirmed by growth cone turning assays and Ca2+ imaging. Furthermore, we took a reverse-engineering analysis to identify balanced regulation between CaMKII (activator) and PP1 (inhibitor) and then the model performance was validated by reproducing turning assays with inhibitions of CaMKII and PP1. Thus, our study implies that the balance between activator and inhibitor underlies the multi-phasic bi-directional turning response of the growth cone.

  4. Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones.


    Meiri, K F; Pfenninger, K H; Willard, M B


    Growth-associated protein, GAP-43, is a polypeptide that is induced in neurons when they grow axons. We show by means of subcellular fractionation and immunohistochemical localization that GAP-43 is a component of neuronal growth cones as well as growing neurites; it is similar to a major phosphoprotein, pp46, of a growth cone-enriched subcellular fraction. These conclusions are consistent with the possibility that the induction of GAP-43/pp46 is an important event in the establishment of a p...

  5. Suppression of Radixin and Moesin Alters Growth Cone Morphology, Motility, and Process Formation In Primary Cultured Neurons (United States)

    Paglini, Gabriela; Kunda, Patricia; Quiroga, Santiago; Kosik, Kenneth; Cáceres, Alfredo


    In this study we have examined the cellular functions of ERM proteins in developing neurons. The results obtained indicate that there is a high degree of spatial and temporal correlation between the expression and subcellular localization of radixin and moesin with the morphological development of neuritic growth cones. More importantly, we show that double suppression of radixin and moesin, but not of ezrin–radixin or ezrin–moesin, results in reduction of growth cone size, disappearance of radial striations, retraction of the growth cone lamellipodial veil, and disorganization of actin filaments that invade the central region of growth cones where they colocalize with microtubules. Neuritic tips from radixin–moesin suppressed neurons displayed high filopodial protrusive activity; however, its rate of advance is 8–10 times slower than the one of growth cones from control neurons. Radixin–moesin suppressed neurons have short neurites and failed to develop an axon-like neurite, a phenomenon that appears to be directly linked with the alterations in growth cone structure and motility. Taken collectively, our data suggest that by regulating key aspects of growth cone development and maintenance, radixin and moesin modulate neurite formation and the development of neuronal polarity. PMID:9786954

  6. Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones. (United States)

    He, Yingpei; Ren, Yuan; Wu, Bingbing; Decourt, Boris; Lee, Aih Cheun; Taylor, Aaron; Suter, Daniel M


    Src tyrosine kinases have been implicated in axonal growth and guidance; however, the underlying cellular mechanisms are not well understood. Specifically, it is unclear which aspects of actin organization and dynamics are regulated by Src in neuronal growth cones. Here, we investigated the function of Src2 and one of its substrates, cortactin, in lamellipodia and filopodia of Aplysia growth cones. We found that up-regulation of Src2 activation state or cortactin increased lamellipodial length, protrusion time, and actin network density, whereas down-regulation had opposite effects. Furthermore, Src2 or cortactin up-regulation increased filopodial density, length, and protrusion time, whereas down-regulation promoted lateral movements of filopodia. Fluorescent speckle microscopy revealed that rates of actin assembly and retrograde flow were not affected in either case. In summary, our results support a model in which Src and cortactin regulate growth cone motility by increasing actin network density and protrusion persistence of lamellipodia by controlling the state of actin-driven protrusion versus retraction. In addition, both proteins promote the formation and stability of actin bundles in filopodia. © 2015 He et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (

  7. beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones

    Directory of Open Access Journals (Sweden)

    Goh Eyleen LK


    Full Text Available Abstract Several myelin-associated factors that inhibit axon growth of mature neurons, including Nogo66, myelin-associated glycoprotein (MAG and oligodendrocyte myelin glycoprotein (OMgp, can associate with a common GPI-linked protein Nogo-66 receptor (NgR. Accumulating evidence suggests that myelin inhibitors also signal through unknown NgR-independent mechanisms. Here we show that MAG, a RGD tri-peptide containing protein, forms a complex with β1-integrin to mediate axonal growth cone turning responses of several neuronal types. Mutations that alter the RGD motif in MAG or inhibition of β1-integrin function, but not removal of NgRs, abolish these MAG-dependent events. In contrast, OMgp-induced repulsion is not affected by inhibition of b1-integrin function. We further show that MAG stimulates tyrosine phosphorylation of focal adhesion kinase (FAK, which in turn is required for MAG-induced growth cone turning. These studies identify β1-integrin as a specific mediator for MAG in growth cone turning responses, acting through FAK activation.

  8. Sustained growth but non-sustainable urbanisation in Penang, Malaysia

    DEFF Research Database (Denmark)

    Wangel, Arne; Fold, Niels


    of trade unions, which lack the strength to substantially improve wages or influence the institutions of the labour market. So a frenzied labour market tries to balance the upgrading of skills and the control of wages. The paper concludes that a focus on sustainable urbanisation will renew the debate......Foreign capital, particularly from the transnational electronics industries, has spurred urban growth in Penang, Malaysia. But the demand for labour-quantitative and qualitative-exceeds its supply from the northern states. Local and national labour policies are decided without the involvement...

  9. The discovery of the growth cone and its influence on the study of axon guidance

    Directory of Open Access Journals (Sweden)

    Elisa eTamariz


    Full Text Available For over a century, there has been a great deal of interest in understanding how neural connectivity is established during development and regeneration. Interest in the latter arises from the possibility that knowledge of this process can be used to reestablish lost connections after lesion or neurodegeneration. At the end of the XIX century, Santiago Ramón y Cajal discovered that the distal tip of growing axons contained a structure that he called the growth cone. He proposed that this structure enabled the axon’s oriented growth in response to attractants, now known as chemotropic molecules. He further proposed that the physical properties of the surrounding tissues could influence the growth cone and the direction of growth. This seminal discovery afforded a plausible explanation for directed axonal growth and has led to the discovery of axon guidance mechanisms that include diffusible attractants and repellants and guidance cues anchored to cell membranes or extracellular matrix. In this review the major events in the development of this field are discussed.

  10. Green economic growth premise for sustainable development


    Carmen Lenuţa TRICĂ; Marilena PAPUC


    Accelerating the global issues such as natural resource depletion, damage to the natural environment, economic and financial crises and consumption growth led to the shift of the development paradigm from consumption to sustainable development and recognition of the new path, namely green economy. At the European level a number of international organizations discussed issues of transition to green economy (EC, UNEP, OECD). In 2008, UNEP launched “Green Economy Initiative to Get the Global Mar...

  11. Economic Growth and Sustainable Housing: An Uneasy Relationship

    DEFF Research Database (Denmark)

    Buch-Hansen, Hubert


    Book review of: "Economic Growth and Sustainable Housing: An Uneasy Relationship" by Jin Xue (Routledge, 2014)......Book review of: "Economic Growth and Sustainable Housing: An Uneasy Relationship" by Jin Xue (Routledge, 2014)...

  12. Cdc42 participates in the regulation of ADF/cofilin and retinal growth cone filopodia by brain derived neurotrophic factor. (United States)

    Chen, Tsan-Ju; Gehler, Scott; Shaw, Alisa E; Bamburg, James R; Letourneau, Paul C


    Rho family GTPases have important roles in mediating the effects of guidance cues and growth factors on the motility of neuronal growth cones. We previously showed that the neurotrophin BDNF regulates filopodial dynamics on growth cones of retinal ganglion cell axons through activation of the actin regulatory proteins ADF and cofilin by inhibiting a RhoA-dependent pathway that phosphorylates (inactivates) ADF/cofilin. The GTPase Cdc42 has also been implicated in mediating the effects of positive guidance cues. In this article we investigated whether Cdc42 is involved in the effects of BDNF on filopodial dynamics. BDNF treatment increases Cdc42 activity in retinal neurons, and neuronal incorporation of constitutively active Cdc42 mimics the increases in filopodial number and length. Furthermore, constitutively active and dominant negative Cdc42 decreased and increased, respectively, the activity of RhoA in retinal growth cones, indicating crosstalk between these GTPases in retinal growth cones. Constitutively active Cdc42 mimicked the activation of ADF/cofilin that resulted from BDNF treatment, while dominant negative Cdc42 blocked the effects of BDNF on filopodia and ADF/cofilin. The inability of dominant negative Cdc42 to block ADF/cofilin activation and stimulation of filopodial dynamics by the ROCK inhibitor Y-27632 indicate interaction between Cdc42 and RhoA occurs upstream of ROCK. Our results demonstrate crosstalk occurs between GTPases in mediating the effects of BDNF on growth cone motility, and Cdc42 activity can promote actin dynamics via activation of ADF/cofilin.

  13. Prion protein promotes growth cone development through reggie/flotillin-dependent N-cadherin trafficking


    Bodrikov, Vsevolod; Solis Padilla, Gonzalo; Stürmer, Claudia


    The role of prion protein (PrP) is insufficiently understood partially because PrP-deficient (-/-) neurons from C57BL/6J mice seem to differentiate normally and are functionally mildly impaired. Here, we reassessed this notion and, unexpectedly, discovered that PrP(-/-) hippocampal growth cones were abnormally small and poor in filopodia and cargo-containing vesicles. Based on our findings that PrP-PrP trans-interaction recruits E-cadherin to cell contact sites and reggie microdomains, and th...


    Directory of Open Access Journals (Sweden)



    Full Text Available The current economic and social contexts have brought forth the issues regarding growth and sustainability. The concept of growth has always been linked to an increase in consumption levels, and this inevitably led to pressures on the environment and on the resources that support human activity. Given these circumstances, the question whether we can avoid an environmental disaster while maintaining economic growth, has become more stringent. We chose to approach this aspect by examining the concept of eco-efficiency, a concept that embodies aspects of both economic efficiency and environmental efficiency. Eco-efficiency can be regarded as the effectiveness with which resources are used in order to create products and services that satisfy human needs. Based on this idea, the last decade has produced an increasing number of studies on eco-efficiency and how it can be measured and implemented in the production of goods and services, but also in the field regarding demand patterns. An analysis regarding the aspects of eco-efficiency at the macro level of the Romanian economy is in line with the current environmental concerns, thus I have chosen to cover these questions, as well as the evolution of the locale economy towards a more sustainable development. The outcome of the examined aspects shows that, in spite of an increase in eco-efficiency levels, energy and material consumption and emissions have increased. This raises the question if measuring economic and environmental efficiency by reporting to the GDP value is becoming obsolete and if there is a need to revaluate eco-efficiency indicators in order to measure the transition to a greener and more sustainable development from different points of view.

  15. FLIM FRET Visualization of Cdc42 Activation by Netrin-1 in Embryonic Spinal Commissural Neuron Growth Cones.

    Directory of Open Access Journals (Sweden)

    Benjamin Rappaz

    Full Text Available Netrin-1 is an essential extracellular chemoattractant that signals through its receptor DCC to guide commissural axon extension in the embryonic spinal cord. DCC directs the organization of F-actin in growth cones by activating an intracellular protein complex that includes the Rho GTPase Cdc42, a critical regulator of cell polarity and directional migration. To address the spatial distribution of signaling events downstream of netrin-1, we expressed the FRET biosensor Raichu-Cdc42 in cultured embryonic rat spinal commissural neurons. Using FLIM-FRET imaging we detected rapid activation of Cdc42 in neuronal growth cones following application of netrin-1. Investigating the signaling mechanisms that control Cdc42 activation by netrin-1, we demonstrate that netrin-1 rapidly enriches DCC at the leading edge of commissural neuron growth cones and that netrin-1 induced activation of Cdc42 in the growth cone is blocked by inhibiting src family kinase signaling. These findings reveal the activation of Cdc42 in embryonic spinal commissural axon growth cones and support the conclusion that src family kinase activation downstream of DCC is required for Cdc42 activation by netrin-1.

  16. FLIM FRET Visualization of Cdc42 Activation by Netrin-1 in Embryonic Spinal Commissural Neuron Growth Cones. (United States)

    Rappaz, Benjamin; Lai Wing Sun, Karen; Correia, James P; Wiseman, Paul W; Kennedy, Timothy E


    Netrin-1 is an essential extracellular chemoattractant that signals through its receptor DCC to guide commissural axon extension in the embryonic spinal cord. DCC directs the organization of F-actin in growth cones by activating an intracellular protein complex that includes the Rho GTPase Cdc42, a critical regulator of cell polarity and directional migration. To address the spatial distribution of signaling events downstream of netrin-1, we expressed the FRET biosensor Raichu-Cdc42 in cultured embryonic rat spinal commissural neurons. Using FLIM-FRET imaging we detected rapid activation of Cdc42 in neuronal growth cones following application of netrin-1. Investigating the signaling mechanisms that control Cdc42 activation by netrin-1, we demonstrate that netrin-1 rapidly enriches DCC at the leading edge of commissural neuron growth cones and that netrin-1 induced activation of Cdc42 in the growth cone is blocked by inhibiting src family kinase signaling. These findings reveal the activation of Cdc42 in embryonic spinal commissural axon growth cones and support the conclusion that src family kinase activation downstream of DCC is required for Cdc42 activation by netrin-1.

  17. Semaphorin3A regulates axon growth independently of growth cone repulsion via modulation of TrkA signaling. (United States)

    Ben-Zvi, A; Ben-Gigi, L; Yagil, Z; Lerman, O; Behar, O


    Regulation of axon growth is a critical event in neuronal development. Nerve growth factor (NGF) is a strong inducer of axon growth and survival in the dorsal root ganglia (DRG). Paradoxically, high concentrations of NGF are present in the target region where axon growth must slow down for axons to accurately identify their correct targets. Semaphorin3A (Sema3A), a powerful axonal repellent molecule for DRG neurons, is also situated in their target regions. NGF is a modulator of Sema3A-induced repulsion and death. We show that Sema3A is a regulator of NGF-induced neurite outgrowth via the TrkA receptor, independent of its growth cone repulsion activity. First, neurite outgrowth of DRG neurons is more sensitive to Sema3A than repulsion. Second, at concentrations sufficient to significantly inhibit Sema3A-induced repulsion, NGF has no effect on Sema3A-induced axon growth inhibition. Third, Sema3A-induced outgrowth inhibition, but not repulsion activity, is dependent on NGF stimulation. Fourth, Sema3A attenuates TrkA-mediated growth signaling, but not survival signaling, and over-expression of constitutively active TrkA blocks Sema3A-induced axon growth inhibition, suggesting that Sema3A activity is mediated via regulation of NGF/TrkA-induced growth. Finally, quantitative analysis of axon growth in vivo supports the possibility that Sema3A affects axon growth, in addition to its well-documented role in axon guidance. We suggest a model whereby NGF at high concentrations in the target region is important for survival, attraction and inhibition of Sema3A-induced repulsion, while Sema3A inhibits its growth-promoting activity. The combined and cross-modulatory effects of these two signaling molecules ensure the accuracy of the final stages in axon targeting.

  18. Corneal Sulfated Glycosaminoglycans and Their Effects on Trigeminal Nerve Growth Cone Behavior In Vitro: Roles for ECM in Cornea Innervation (United States)

    Schwend, Tyler; Deaton, Ryan J.; Zhang, Yuntao; Caterson, Bruce; Conrad, Gary W.


    Purpose. Sensory trigeminal nerve growth cones innervate the cornea in a highly coordinated fashion. The purpose of this study was to determine if extracellular matrix glycosaminoglycans (ECM–GAGs), including keratan sulfate (KS), dermatan sulfate (DS), and chondroitin sulfate A (CSA) and C (CSC), polymerized in developing eyefronts, may provide guidance cues to nerves during cornea innervation. Methods. Immunostaining using antineuron-specific-β-tubulin and monoclonal antibodies for KS, DS, and CSA/C was performed on eyefronts from embryonic day (E) 9 to E14 and staining visualized by confocal microscopy. Effects of purified GAGs on trigeminal nerve growth cone behavior were tested using in vitro neuronal explant cultures. Results. At E9 to E10, nerves exiting the pericorneal nerve ring grew as tight fascicles, advancing straight toward the corneal stroma. In contrast, upon entering the stroma, nerves bifurcated repeatedly as they extended anteriorly toward the epithelium. KS was localized in the path of trigeminal nerves, whereas DS and CSA/C–rich areas were avoided by growth cones. When E10 trigeminal neurons were cultured on different substrates comprised of purified GAG molecules, their neurite growth cone behavior varied depending on GAG type, concentration, and mode of presentation (immobilized versus soluble). High concentrations of immobilized KS, DS, and CSA/C inhibited neurite growth to varying degrees. Neurites traversing lower, permissive concentrations of immobilized DS and CSA/C displayed increased fasciculation and decreased branching, whereas KS caused decreased fasciculation and increased branching. Enzymatic digestion of sulfated GAGs canceled their effects on trigeminal neurons. Conclusions. Data herein suggest that GAGs may direct the movement of trigeminal nerve growth cones innervating the cornea. PMID:23132805

  19. Western and Chinese Development Discourses: Education, Growth and Sustainability (United States)

    Nordtveit, Bjorn Harald


    This article examines Western and Chinese discourses of education, sustainable growth and development. Education is increasingly considered as a means to fuel economic growth, especially since the 1980s, when conservative economic values became predominant in Western development thought. Despite a discourse on sustainability favouring ecologically…

  20. Soil Degradation, Policy Intervention and Sustainable Agricultural Growth

    NARCIS (Netherlands)

    Sasmal, J.; Weikard, H.P.


    Sustainable agricultural growth in developing countries is jeopardized by soil degradation consequent upon intensive cultivation and use of increasing doses of chemical inputs. To pave the way to sustainable agricultural growth we develop a model that incorporates organic fertilizer into the

  1. Corruption and Challenges of Sustainable Inclusive Growth in Nigeria

    African Journals Online (AJOL)

    The paper examines Corruption and Challenges of Sustainable Inclusive Growth in Nigeria. The paper adopts the theory of two publics as its framework of analysis. The theory explains the prevalence of corruption between and among public servants in Nigeria, which affects the attainment of sustainable inclusive growth.

  2. Green economic growth premise for sustainable development

    Directory of Open Access Journals (Sweden)

    Carmen Lenuţa TRICĂ


    Full Text Available Accelerating the global issues such as natural resource depletion, damage to the natural environment, economic and financial crises and consumption growth led to the shift of the development paradigm from consumption to sustainable development and recognition of the new path, namely green economy.At the European level a number of international organizations discussed issues of transition to green economy (EC, UNEP, OECD. In 2008, UNEP launched “Green Economy Initiative to Get the Global Markets Back to Work”, aiming to mobilize and re-focuse the global economy towards.This is the twin challenge of moving towards a green economy: radically reducing the footprint of developed countries, while simultaneously raising levels of social and material well being in developing countries.Without public intervention, the related market failures (i.e. market prices that do not fully reflect the environmental degradation generated by economic activity may delay or even prevent the development of environmentally-friendly technologies.Furthermore, in sectors such as electricity, network effects arising from existing infrastructures create additional barriers to the adoption of alternative sources of power, further hampering incentives to invest in new technologies.Given that the transition to a green economy requires increasing of investment in economic sectors that contribute to enhancing of natural capital and reduce environmental risks, we intend to analyze the main measures taken by Romania to ensure transition to green economy.

  3. Nerve growth factor stimulates axon outgrowth through negative regulation of growth cone actomyosin restraint of microtubule advance (United States)

    Turney, Stephen G.; Ahmed, Mostafa; Chandrasekar, Indra; Wysolmerski, Robert B.; Goeckeler, Zoe M.; Rioux, Robert M.; Whitesides, George M.; Bridgman, Paul C.


    Nerve growth factor (NGF) promotes growth, differentiation, and survival of sensory neurons in the mammalian nervous system. Little is known about how NGF elicits faster axon outgrowth or how growth cones integrate and transform signal input to motor output. Using cultured mouse dorsal root ganglion neurons, we found that myosin II (MII) is required for NGF to stimulate faster axon outgrowth. From experiments inducing loss or gain of function of MII, specific MII isoforms, and vinculin-dependent adhesion-cytoskeletal coupling, we determined that NGF causes decreased vinculin-dependent actomyosin restraint of microtubule advance. Inhibition of MII blocked NGF stimulation, indicating the central role of restraint in directed outgrowth. The restraint consists of myosin IIB- and IIA-dependent processes: retrograde actin network flow and transverse actin bundling, respectively. The processes differentially contribute on laminin-1 and fibronectin due to selective actin tethering to adhesions. On laminin-1, NGF induced greater vinculin-dependent adhesion–cytoskeletal coupling, which slowed retrograde actin network flow (i.e., it regulated the molecular clutch). On fibronectin, NGF caused inactivation of myosin IIA, which negatively regulated actin bundling. On both substrates, the result was the same: NGF-induced weakening of MII-dependent restraint led to dynamic microtubules entering the actin-rich periphery more frequently, giving rise to faster elongation. PMID:26631553

  4. Managed Sustainable Development Classification Of Resources And Goods amp Services Calculating Sustainable Growth Rate And The Sustainable Development Index

    Directory of Open Access Journals (Sweden)

    Shubham Saxena


    Full Text Available Macro-level manmade problems can often be best solved by understanding and manipulating the economics behind it. The world today is facing genuine problems of scarcity of resources and environmental amp ecological issues in view of intergenerational equity. The paper proposes a new approach of identification and classification of i Resources and ii Goods and services in the context of sustainable development. Every economy has ambitious economic growth aspirations which are often found conflicting with the commitments on natural resource conservation and climate change obligations. The proposed methodology is a reconciliation of the aspired economic growth of a region and the conservation of the resources and nature. The paper employs contribution of different types of goods and services in the gross domestic product GDP of a region to analyze sustainability of development. The important parameters that the paper establishes are Sustainability Ratio R Sustainable Growth Rate SG and the Sustainable Development Index SI. These parameters can be used to compare the sustainable development level of different regions. Ensuring natural resource and environmental sustainability will eventually ensure economic sustainability. The paper considers resource depletion concerns as well as the environmental pollutants biological risks carbon footprint warhead proliferation et cetera thereby ensuring all round sustainability from survival to economic end. The sustainability analysis is done for long periods such as 50 years 100 years et cetera. The index shows how sustainable the development of an economy is and how sustainability it is growing. The presently much revered GDP growth numbers are directionless it does not tell the type of growth an economy essentially has. The direction should be sustainability which the paper stresses upon. An illustration of sustainability analysis of India is also done. Such indices can help identifying sustainably developing

  5. Optimum design of sustainable sealed low volume roads using the Dynamic Cone Penetrometer (DCP)

    CSIR Research Space (South Africa)

    Paige-Green, P


    Full Text Available Sustainable upgrading of unsealed roads to a low volume sealed standard is best accomplished by maximising the use of the in situ materials within the prevailing road environment. Over the years and under traffic loading, unsealed roads achieve a...

  6. Sustainable Development and Sustainable Growth: Conceptual Plane or Points on a Conceptual Plain?

    DEFF Research Database (Denmark)

    Ulhøi, John Parm; Madsen, Henning

    ) becoming an empty catch-phrase of contemporary environmentalism, a thorough analysis and discussion of the concept is therefore required. A distinction is made between sustainable growth and sustainable development. In the general debate sustainable growth is often used by politicians and developers...... as synonym for sustainable development. It is argued, however, that this is either a misunderstanding based on a superficial knowledge about the meaning of the sustainability concept or simply that it is cynically used to make the traditional growth philosophy more 'digestible' in an age of increasing...... environmental concern. Except from the concept of industrial ecology, present environmental responses from industry bear little resemblance with a basic systems approach to the concept of sustainability. A systems approach, as in constrast to a reductionist approach, holds promises for paving the way...

  7. An Automated Strategy for Unbiased Morphometric Analyses and Classifications of Growth Cones In Vitro.

    Directory of Open Access Journals (Sweden)

    Daryan Chitsaz

    Full Text Available During neural circuit development, attractive or repulsive guidance cue molecules direct growth cones (GCs to their targets by eliciting cytoskeletal remodeling, which is reflected in their morphology. The experimental power of in vitro neuronal cultures to assay this process and its molecular mechanisms is well established, however, a method to rapidly find and quantify multiple morphological aspects of GCs is lacking. To this end, we have developed a free, easy to use, and fully automated Fiji macro, Conographer, which accurately identifies and measures many morphological parameters of GCs in 2D explant culture images. These measurements are then subjected to principle component analysis and k-means clustering to mathematically classify the GCs as "collapsed" or "extended". The morphological parameters measured for each GC are found to be significantly different between collapsed and extended GCs, and are sufficient to classify GCs as such with the same level of accuracy as human observers. Application of a known collapse-inducing ligand results in significant changes in all parameters, resulting in an increase in 'collapsed' GCs determined by k-means clustering, as expected. Our strategy provides a powerful tool for exploring the relationship between GC morphology and guidance cue signaling, which in particular will greatly facilitate high-throughput studies of the effects of drugs, gene silencing or overexpression, or any other experimental manipulation in the context of an in vitro axon guidance assay.

  8. Population growth: Implications for environmental sustainability ...

    African Journals Online (AJOL)

    The impact of population growth on environment and its implication for survival is an important issue. Although considerable attention has been paid to this problem but systematic studies have been inadequate. Rapid population growth and economic development and daily demand for natural resources for domestic and ...

  9. Nanotechnology policy in Korea for sustainable growth (United States)

    So, Dae Sup; Kim, Chang Woo; Chung, Pil Seung; Jhon, Myung S.


    Korea has become one of the leading countries in nanotechnology along with the U.S., Japan, and Germany. Since 2001, the Korean Government established the "Nanotechnology Development Plan." Since then, the trend in nanotechnology is steadily changing from fundamental research to application-driven technologies. In this paper, we examine the nanotechnology development and policy during the past decade, which includes the investments in R&D, infrastructure, and education. The Third Phase (2011-2020) on clean nanotechnology convergence and integration in information, energy, and the environmental sector is also given. Furthermore, the program on long-term strategy dealing with sustainability in resolving future societal demand and plans for sustainable energy and environmental activities will be discussed in depth. The outcomes and national evaluations of research and education are also given.

  10. Rooting, growth and sustainability of yellow Ficus ( Ficus retusa ...

    African Journals Online (AJOL)

    Rooting, growth and sustainability of yellow Ficus ( Ficus retusa 'Nitida') as affected by growth media under nursery conditions. ... Significantly (P<0.05) highest vegetative and root length was produced by plants grown on a mixture of sawdust, cow dung and topsoil (1:1:3). Root length of Ficus retusa 'Nitida' was best ...

  11. Public Debt, Corruption and Sustainable Economic Growth

    Directory of Open Access Journals (Sweden)

    Eunji Kim


    Full Text Available There are many studies that look into the relationship between public debt and economic growth. It is hard to find, however, research addressing the role of corruption between these two variables. Noticing this vacancy in current literature, we strive to investigate the effect of corruption on the relationship between public debt and economic growth. For this purpose, the pooled ordinary least squares (OLS, fixed effects models and the dynamic panel generalized method of moments (GMM models (Arellano-Bond, 1991 are estimated with data of 77 countries from 1990 to 2014. The empirical results show that the interaction term between public debt and corruption is statistically significant. This confirms the hypothesis that the effect of public debt on economic growth is a function of corruption. The sign of the marginal effect is negative in corrupt countries, but public debt enhances economic growth within countries that are not corrupt, i.e., highly transparent.

  12. Financial Markets and the Challenges of Sustainable Growth

    Directory of Open Access Journals (Sweden)

    Janicka Małgorzata


    Full Text Available Sustainable growth and responsibility for the economy and the environment are postulates rarely associated with the term “financial market”. Financial markets are identified with the ruthless maximisation of profit at acceptable risk, rather than with socially responsible conduct. However, in the global economy businesses modify their priorities and become aware of not just the need to grow in financial terms but also to improve their quality performance. International financial markets have become part of this trend and are increasingly often adopting environmentally friendly attitudes and embracing the challenges posed by the concept of sustainable growth. Ideas such as CSR – Corporate Social Responsibility – and SRI – Socially Responsible Investment are gaining in importance. While sustainable growth of the economy as perceived from the point of view of the manufacturing or service sectors is widely discussed, the sustainable growth of financial markets is a relatively new concept and the available literature on “green” financial markets is quite scarce. This paper is intended to fill in this gap and examine the changes that have taken place on financial markets in the context of the idea of sustainable growth, with particular attention paid to the European Union markets.

  13. Sustaining an Acquisition-based Growth Strategy

    DEFF Research Database (Denmark)

    Henningsson, Stefan; Toppenberg, Gustav; Shanks, Graeme

    Value creating acquisitions are a major challenge for many firms. Our case study of Cisco Systems shows that an advanced Enterprise Architecture (EA) capability can contribute to the acquisition process through a) preparing the acquirer to become ‘acquisition ready’, b) identifying resource......-based growth strategy over time....

  14. Natural blends, sustainable innovations and income growth

    NARCIS (Netherlands)

    Krozer, Y.; Brezet, J.C.


    The paper discusses innovations for both income growth and the generation of better environmental qualities. This is possible in theory but progress in practices is slow. We argue that social pressures to contain pollution were effective insofar they invoked environmental policies all over the

  15. Tourism in Austria: biodiversity, environmental sustainability, and growth issues. (United States)

    Malik, Muhammad Asad Saleem; Shah, Syed Asim; Zaman, Khalid


    This study examined the long-run and causal relationships between international tourism, biodiversity loss, environmental sustainability, and specific growth factors under the premises of sustainable tourism in Austria, by using a consistent time series data from 1975 to 2015. The results reveal that inbound tourism, per capita income, and population density affected the potential habitat area while population density largely affected the food production in a country. Inbound tourism and population density both deteriorate the environmental quality in a form of increasing carbon dioxide (CO2) emissions and fossil fuel energy consumption while per capita income reduces the fossil fuel energy consumption. Food exports increase per capita income, while food imports and population density both decrease economic growth. Inbound tourism and economic growth advance population density while forest area and food exports decrease the population density. The study supports growth-led tourism and growth-led food production in a country.

  16. Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. (United States)

    Kolpak, Adrianne L; Jiang, Jun; Guo, Daorong; Standley, Clive; Bellve, Karl; Fogarty, Kevin; Bao, Zheng-Zheng


    Macropinocytosis is a type of poorly characterized fluid-phase endocytosis that results in formation of relatively large vesicles. We report that Sonic hedgehog (Shh) protein induces macropinocytosis in the axons through activation of a noncanonical signaling pathway, including Rho GTPase and nonmuscle myosin II. Macropinocytosis induced by Shh is independent of clathrin-mediated endocytosis but dependent on dynamin, myosin II, and Rho GTPase activities. Inhibitors of macropinocytosis also abolished the negative effects of Shh on axonal growth, including growth cone collapse and chemorepulsive axon turning but not turning per se. Conversely, activation of myosin II or treatment of phorbol ester induces macropinocytosis in the axons and elicits growth cone collapse and repulsive axon turning. Furthermore, macropinocytosis is also induced by ephrin-A2, and inhibition of dynamin abolished repulsive axon turning induced by ephrin-A2. Macropinocytosis can be induced ex vivo by high Shh, correlating with axon retraction. These results demonstrate that macropinocytosis-mediated membrane trafficking is an important cellular mechanism involved in axon chemorepulsion induced by negative guidance factors.

  17. The Impact of Subsidies on Production Innovation and Sustainable Growth

    Directory of Open Access Journals (Sweden)

    Žampa Sabina


    Full Text Available This paper investigates correlation between subsidies to invest in development projects, innovation, financial performance and sustainable growth. The focus of the study is on subsidies for co-financing purchases of new technological equipment aimed at promoting innovation and production of new products. Subsidies are distributed based on the prepared European Union (EU and national programs for the purposes of faster economic growth in accordance with the policies and guidelines of the EU. The paper employs a combination of enterprises’ accounting data, data on subsidies and unique in-depth data obtained through a survey at the enterprise level. The results revealed a positive impact of subsidies on financial indicators, and only limited effect on innovation. While analyzing sustainable growth, we have established that the enterprises that received subsidies had a higher growth of financial indicators.

  18. Networks: Innovation, Growth and Sustainable Development

    Directory of Open Access Journals (Sweden)

    Peter Johnston


    Full Text Available The emergence of the Internet as a measureable manifestation of our social and economic relationships changed the domination of networks in our lives. From about 2000, the internet has allowed us to study and understand the type of networks in which we live, and to model their behaviour. The Internet has fundamentally changed the distribution of wealth. The rich became richer simply because of the larger scale of the trading network and stretched national wealth distributions. Network effects are therefore likely to be responsible for much of the perceived increases in inequalities in the last 20-30 years, and policies to tackle poverty must therefore address the extent to which the poor can engage with society's networks of wealth creation. The greatest challenge to continued growth and prosperity, and therefore to peace and justice, is climate change. The potential cost of inaction on climate change could be as high. Our self-organising social networks have structured our societies and economies, and are now reflected in our technology networks. We can now replicate their evolution in computer simulations and can therefore better assess how to deal with the greatest challenges facing us in the next few decades.

  19. Tackling the dual challenge of sustainable consumption and economic growth

    DEFF Research Database (Denmark)

    Sedlacko, Michal; Antunes, Paula; Asara, Viviana

    to ecosystem services have spurred parts of the academic and policy communities into identification of problems and solutions. Some of the most fundamental debates, led by researchers from various disciplines, centre around economic growth and sustainable consumption. However, there is often a lack...... research questions that link the challenges of sustainable consumption with economic growth debates and critiques. The research questions have been identified through an extensive participatory process involving leading researchers and policy makers responsible for sustainability policies throughout...... the whole EU and cover five areas (food, housing, mobility, information and communication technology, finance). The aim of the research questions is to orient researchers towards important research priorities as well as guide policy makers and public authorities in funding of research and use of sound...

  20. Plant Growth-Promoting Microorganisms for Environmental Sustainability. (United States)

    Abhilash, P C; Dubey, Rama Kant; Tripathi, Vishal; Gupta, Vijai K; Singh, Harikesh B


    Agrochemicals used to meet the needs of a rapidly growing human population can deteriorate the quality of ecosystems and are not affordable to farmers in low-resource environments. Here, we propose the use of plant growth-promoting microorganisms (PGPMs) as a tool for sustainable food production without compromising ecosystems services. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Protein interacting with NIMA (never in mitosis A)-1 regulates axonal growth cone adhesion and spreading through myristoylated alanine-rich C kinase substrate isomerization. (United States)

    Sosa, Lucas J; Malter, James S; Hu, Jie; Bustos Plonka, Florentyna; Oksdath, Mariana; Nieto Guil, Alvaro F; Quiroga, Santiago; Pfenninger, Karl H


    Axonal growth cone motility requires precise regulation of adhesion to navigate the complex environment of the nervous system and reach its target. Myristoylated alanine-rich C kinase substrate (MARCKS) protein is enriched in the developing brain and plays an important, phosphorylation-dependent role in the modulation of axonal growth cone adhesion. The ratio of phospho-MARCKS (MARCKS-P) to total MARCKS controls adhesion modulation and spreading of the axonal growth cone. Pin1, a peptidyl-prolyl cis/trans isomerase (PPIase) that recognizes and binds to phosphorylated serine/threonine residues preceded by a proline (pSer/Thr-Pro) is also expressed in the developing brain. Here, we show that Pin1 is present in the growth cone, interacts with MARCKS-P, and regulates its dephosphorylation. We also described morphological alterations in the corpus callosum and cerebral cortex fibers of the Pin1 knockout mouse brain that may be caused by the misregulation of MARCKS-P and alterations of neuronal adhesion. We have shown that MARCKS, a critical protein in the movement of neuronal growth cones, is in turn regulated by both phosphorylation and cis-trans peptidyl isomerization mediated by Pin1. In the absence of Pin1, MARCKS is hyperphosphorylated, leading to loss of adhesions, and collapse of the growth cone. The Pin1 KO mice exhibited disturbed neuronal projections from the cerebral cortex and reduced white matter tracks such as the corpus callosum. This study highlights a novel function of Pin1 in neurodevelopment. © 2016 International Society for Neurochemistry.

  2. Cold knife cone biopsy (United States)

    ... biopsy; Pap smear - cone biopsy; HPV - cone biopsy; Human papilloma virus - cone biopsy; Cervix - cone biopsy; Colposcopy - cone biopsy Images Female reproductive anatomy Cold cone biopsy Cold cone removal References American ...

  3. CRESCIMENTO ECONÔMICO E SUSTENTABILIDADE / Economic Growth and Sustainability

    Directory of Open Access Journals (Sweden)

    Gilberto Montibeller-Filho


    Full Text Available The subject “economic growth and sustainability” refers to the relationship between economicgrowth and its positive impact on the wellbeing of the population and on the environment. It is,therefore, about economic, as well as social and environmental, sustainability, i.e. the root ofthe sustainable development paradigm. A historical review is needed for understanding theroots of the emergence of this new socio-political and scientific paradigm. It starts from themoment when the economy was mainly viewed as an evil against the environment, to the pointwhen the new sustainable development, or eco-development, is developed. Then the paperpresents the present, and most important, ways that several public and private actions attemptto develop their economic activities guided by this paradigm, emphasising the Brazilian context.


    Directory of Open Access Journals (Sweden)

    Aida CATANA


    Full Text Available The demographic dynamics analysed in the context of the relationship between economic development and social inclusion presents an image of the sustainable development of a community as well as the manner how the financial resources have been used. With an allocation of 74.3 million euro in the programming period 2007-2013, the Brasov Growth Pole has pursued the contribution to the achievement of sustainable development since 2005 by the participation in the Agenda 21. The implementation of projects with European financing in areas such as transport, social and educational infrastructure or tourism have generated changes/demographic movements, which this paper proposes to present. The evolution of the stable population, its dynamics at the level of each locality that is part of the Brasov growth pole as well as the dynamics of the number of employees or the development of the unemployment rate are presented by the cluster analysis. The effects of the European financing obtained from Regional Operational Programme 2007-2013 are thus reflected in the sustainable development of the Brasov growth pole from the point of view of the dynamics of the population

  5. A mechanism for the polarity formation of chemoreceptors at the growth cone membrane for gradient amplification during directional sensing.

    Directory of Open Access Journals (Sweden)

    Cedric Bouzigues

    Full Text Available Accurate response to external directional signals is essential for many physiological functions such as chemotaxis or axonal guidance. It relies on the detection and amplification of gradients of chemical cues, which, in eukaryotic cells, involves the asymmetric relocalization of signaling molecules. How molecular events coordinate to induce a polarity at the cell level remains however poorly understood, particularly for nerve chemotaxis. Here, we propose a model, inspired by single-molecule experiments, for the membrane dynamics of GABA chemoreceptors in nerve growth cones (GCs during directional sensing. In our model, transient interactions between the receptors and the microtubules, coupled to GABA-induced signaling, provide a positive-feedback loop that leads to redistribution of the receptors towards the gradient source. Using numerical simulations with parameters derived from experiments, we find that the kinetics of polarization and the steady-state polarized distribution of GABA receptors are in remarkable agreement with experimental observations. Furthermore, we make predictions on the properties of the GC seen as a sensing, amplification and filtering module. In particular, the growth cone acts as a low-pass filter with a time constant approximately 10 minutes determined by the Brownian diffusion of chemoreceptors in the membrane. This filtering makes the gradient amplification resistant to rapid fluctuations of the external signals, a beneficial feature to enhance the accuracy of neuronal wiring. Since the model is based on minimal assumptions on the receptor/cytoskeleton interactions, its validity extends to polarity formation beyond the case of GABA gradient sensing. Altogether, it constitutes an original positive-feedback mechanism by which cells can dynamically adapt their internal organization to external signals.

  6. Three-dimensional longitudinal changes in craniofacial growth in untreated hemifacial microsomia patients with cone-beam computed tomography. (United States)

    Shibazaki-Yorozuya, Reiko; Yamada, Akira; Nagata, Satoru; Ueda, Kouichi; Miller, Arthur J; Maki, Koutaro


    The purpose of this study was to evaluate the concept that the affected and contralateral sides do not grow at the same rate in patients with hemifacial microsomia. Changes in the cranial base, maxilla, mandible, and occlusal plane were evaluated on 3-dimensional images from cone-beam computed tomography data in untreated patients. Six patients were classified as having mandibular Pruzansky/Kaban type I, IIA, or IIB hemifacial microsomia. Cone-beam computed tomography (MercuRay; Hitachi, Tokyo, Japan) scans were taken before orthodontic treatment during both growth and postpuberty periods. The cranial base as defined by the position of the mastoid process was in a different position between the affected and contralateral control sides. The nasomaxillary length or height was shorter on the affected side for all 6 patients with hemifacial microsomia regardless of its severity, and it grew less than on the contralateral control side in 5 of the 6 patients. The occlusal plane angle became more inclined in 4 of the 6 patients. The mandibular ramus was shorter on the affected side in all patients and grew less on the affected side in 5 of the 6 patients. The mandibular body grew slower, the same, or faster than on the control side. The cranial base, position of the condyle, lengths of the condyle and ramus, and positions of the gonial angle and condyle can vary between the affected and contralateral control sides of patients with hemifacial microsomia, with the ramus and nasomaxillary length usually growing slower than they grow on the control side. These results suggest that many factors affect the growth rate of the craniofacial region and, specifically, the mandible in patients with hemifacial microsomia. Copyright © 2014 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

  7. Factors affecting cone production in Pinus pinaster Ait.: lack of growth-reproduction trade-offs but significant effects of climate and tree and stand characteristics

    Energy Technology Data Exchange (ETDEWEB)

    Bravo, F.; Maguire, D.A.; González-Martínez, S.G.


    Aim of study: Our main goal is to determine the relationship between cone production and radial growth in Pinus pinaster Ait. under different climatic conditions across the Iberian Peninsula. Area of study: Coca Intensive Sampling Plateau, Northern Plateau (Spain). Material and methods: Cone counts were conducted on an intensive monitoring plot in Coca (North-Central Spain) during the years 2000, 2006 and 2007. A ZIP (zero-inflated Poisson) model was adjusted for simultaneously estimating the probability of obtaining crop cones and its amount. The Northern Atlantic Oscillation (NAO) index was used as explanatory variable, together with a wide variety of tree and local stand variables. Climate (as evaluated by NAO), local stand density (here estimated from the six nearest trees), tree size and vigor, competition and growth efficiency significantly influenced both occurrence and intensity of cone production. Main results: ZIP models for predicting reproductive effort seems an adequate tool to predict reproductive responses to climatic fluctuations and the resulting future species distribution in the face of climate change, as well as to identify silviculture actions that would promote reproductive success in naturally-regenerated stands, list and discuss relevant results (including numeric values of experimental results). Research highlights: Climate, stand density and tree conditions (size and vigor, competition and growth efficiency) influence significantly both cone occurrence and intensity of fruiting as shown by a ZIP model. As the climate variables included in the model (based on Northern Atlantic Oscillation, NAO) are general and easily obtained, the proposed model has practical applicability to predicting Pinus pinaster cone production in the Iberian Peninsula.

  8. Factors affecting cone production in Pinus pinaster Ait.: lack of growth-reproduction trade-offs but significant effects of climate and tree and stand characteristics

    Directory of Open Access Journals (Sweden)

    Felipe Bravo


    Full Text Available Aim of study: Our main goal is to determine the relationship between cone production and radial growth in Pinus pinaster Ait. under different climatic conditions across the Iberian Peninsula. Area of study: Coca Intensive Sampling Plateau, Northern Plateau (Spain. Material and methods: Cone counts were conducted on an intensive monitoring plot in Coca (North-Central Spain during the years 2000, 2006 and 2007. A ZIP (zero-inflated Poisson model was adjusted for simultaneously estimating the probability of obtaining crop cones and its amount. The Northern Atlantic Oscillation (NAO index was used as explanatory variable, together with a wide variety of tree and local stand variables. Climate (as evaluated by NAO, local stand density (here estimated from the six nearest trees, tree size and vigor, competition and growth efficiency significantly influenced both occurrence and intensity of cone production. Main results: ZIP models for predicting reproductive effort seems an adequate tool to predict reproductive responses to climatic fluctuations and the resulting future species distribution in the face of climate change, as well as to identify silviculture actions that would promote reproductive success in naturally-regenerated stands, list and discuss relevant results (including numeric values of experimental results. Research highlights: Climate, stand density and tree conditions (size and vigor, competition and growth efficiency influence significantly both cone occurrence and intensity of fruiting as shown by a ZIP model. As the climate variables included in the model (based on Northern Atlantic Oscillation, NAO are general and easily obtained, the proposed model has practical applicability to predicting Pinus pinaster cone production in the Iberian Peninsula.

  9. Cell longevity and sustained primary growth in palm stems. (United States)

    Tomlinson, P Barry; Huggett, Brett A


    Longevity, or organismal life span, is determined largely by the period over which constituent cells can function metabolically. Plants, with modular organization (the ability continually to develop new organs and tissues) differ from animals, with unitary organization (a fixed body plan), and this difference is reflected in their respective life spans, potentially much longer in plants than animals. We draw attention to the observation that palm trees, as a group of monocotyledons without secondary growth comparable to that of lignophytes (plants with secondary growth from a bifacial cambium), retain by means of sustained primary growth living cells in their trunks throughout their organismal life span. Does this make palms the longest-lived trees because they can grow as individuals for several centuries? No conventional lignophyte retains living metabolically active differentiated cell types in its trunk for this length of time, even though the tree as a whole can exist for millennia. Does this contrast also imply that the long-lived cells in a palm trunk have exceptional properties, which allows this seeming immortality? We document the long-life of many tall palm species and their inherent long-lived stem cell properties, comparing such plants to conventional trees. We provide a summary of aspects of cell age and life span in animals and plants. Cell replacement is a feature of animal function, whereas conventional trees rely on active growth centers (meristems) to sustain organismal development. However, the long persistence of living cells in palm trunks is seen not as evidence for unique metabolic processes that sustain longevity, but is a consequence of unique constructional features. This conclusion suggests that the life span of plant cells is not necessarily genetically determined.

  10. Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. (United States)

    Purohit, Anish A; Li, Weiquan; Qu, Chao; Dwyer, Trisha; Shao, Qiangqiang; Guan, Kun-Liang; Liu, Guofa


    In the developing nervous system, neuronal growth cones explore the extracellular environment for guidance cues, which can guide them along specific trajectories toward their targets. Netrin-1, a bifunctional guidance cue, binds to deleted in colorectal cancer (DCC) and DSCAM mediating axon attraction, and UNC5 mediating axon repulsion. Here, we show that DSCAM interacts with UNC5C and this interaction is stimulated by netrin-1 in primary cortical neurons and postnatal cerebellar granule cells. DSCAM partially co-localized with UNC5C in primary neurons and brain tissues. Netrin-1 induces axon growth cone collapse of mouse cerebellum external granule layer (EGL) cells, and the knockdown of DSCAM or UNC5C by specific shRNAs or blocking their signaling by overexpressing dominant negative mutants suppresses netrin-1-induced growth cone collapse. Similarly, the simultaneous knockdown of DSCAM and UNC5C also blocks netrin-1-induced growth cone collapse in EGL cells. Netrin-1 increases tyrosine phosphorylation of endogenous DSCAM, UNC5C, FAK, Fyn, and PAK1, and promotes complex formation of DSCAM with these signaling molecules in primary postnatal cerebellar neurons. Inhibition of Src family kinases efficiently reduces the interaction of DSCAM with UNC5C, FAK, Fyn, and PAK1 and tyrosine phosphorylation of these proteins as well as growth cone collapse of mouse EGL cells induced by netrin-1. The knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1. Our study reveals the first evidence that DSCAM coordinates with UNC5C in netrin-1 repulsion.

  11. Resource Demand Growth and Sustainability Due to Increased World Consumption

    Directory of Open Access Journals (Sweden)

    Alexander V. Balatsky


    Full Text Available The paper aims at continuing the discussion on sustainability and attempts to forecast the impossibility of the expanding consumption worldwide due to the planet’s limited resources. As the population of China, India and other developing countries continue to increase, they would also require more natural and financial resources to sustain their growth. We coarsely estimate the volumes of these resources (energy, food, freshwater and the gross domestic product (GDP that would need to be achieved to bring the population of India and China to the current levels of consumption in the United States. We also provide estimations for potentially needed immediate growth of the world resource consumption to meet this equality requirement. Given the tight historical correlation between GDP and energy consumption, the needed increase of GDP per capita in the developing world to the levels of the U.S. would deplete explored fossil fuel reserves in less than two decades. These estimates predict that the world economy would need to find a development model where growth would be achieved without heavy dependence on fossil fuels.

  12. Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice. (United States)

    Williams, Scott E; Garcia, Idoia; Crowther, Andrew J; Li, Shiyi; Stewart, Alyssa; Liu, Hedi; Lough, Kendall J; O'Neill, Sean; Veleta, Katherine; Oyarzabal, Esteban A; Merrill, Joseph R; Shih, Yen-Yu Ian; Gershon, Timothy R


    Alterations in genes that regulate brain size may contribute to both microcephaly and brain tumor formation. Here, we report that Aspm, a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports the growth of medulloblastoma, the most common malignant pediatric brain tumor. Cerebellar granule neuron progenitors (CGNPs) express Aspm when maintained in a proliferative state by sonic hedgehog (Shh) signaling, and Aspm is expressed in Shh-driven medulloblastoma in mice. Genetic deletion of Aspm reduces cerebellar growth, while paradoxically increasing the mitotic rate of CGNPs. Aspm-deficient CGNPs show impaired mitotic progression, altered patterns of division orientation and differentiation, and increased DNA damage, which causes progenitor attrition through apoptosis. Deletion of Aspm in mice with Smo-induced medulloblastoma reduces tumor growth and increases DNA damage. Co-deletion of Aspm and either of the apoptosis regulators Bax or Trp53 (also known as p53) rescues the survival of neural progenitors and reduces the growth restriction imposed by Aspm deletion. Our data show that Aspm functions to regulate mitosis and to mitigate DNA damage during CGNP cell division, causes microcephaly through progenitor apoptosis when mutated, and sustains tumor growth in medulloblastoma. © 2015. Published by The Company of Biologists Ltd.

  13. Comparing emergy accounting with well-known sustainability metrics. The case of Southern Cone Common Market, Mercosur

    Energy Technology Data Exchange (ETDEWEB)

    Giannetti, B.F.; Almeida, C.M.V.B.; Bonilla, S.H. [Programa de Pos-Graduacao em Engenharia de Producao, Universidade Paulista, R. Dr. Bacelar 1212, Cep 04026-002, Sao Paulo (Brazil)


    The quality and the power of human activities affect the external environment in different ways that can be measured and evaluated by means of several approaches and indicators. While the scientific community has been publishing several proposals for sustainable development indicators, there is still no consensus regarding the best approach to the use of these indicators and their reliability to measure sustainability. It is important, therefore, to question the effectiveness of sustainable development indicators in an effort to continue in the search for sustainability. This paper compares the results obtained with emergy accounting with five global Sustainability Metrics (SMs) proposed in the literature to verify if metrics are communicating coherent and similar information to guide decision makers towards sustainable development. Results obtained using emergy indices are discussed with the aid of emergy ternary diagrams. Metrics are confronted with emergy results, and the degree of variability among them is analyzed using a correlation matrix created for the Mercosur nations. The contrast of results clearly shows that metrics arrive at different interpretations about the sustainability of the nations studied, but also that some metrics may be grouped and used more prudently. Mercosur is presented as a case study to highlight and explain the discrepancies and similarities among Sustainability Metrics, and to expose the extent of emergy accounting. (author)

  14. Comparing emergy accounting with well-known sustainability metrics: The case of Southern Cone Common Market, Mercosur

    Energy Technology Data Exchange (ETDEWEB)

    Giannetti, B.F. [Programa de Pos-Graduacao em Engenharia de Producao, Universidade Paulista, R. Dr. Bacelar 1212, Cep 04026-002, Sao Paulo (Brazil); Almeida, C.M.V.B., E-mail: cmvbag@unip.b [Programa de Pos-Graduacao em Engenharia de Producao, Universidade Paulista, R. Dr. Bacelar 1212, Cep 04026-002, Sao Paulo (Brazil); Bonilla, S.H. [Programa de Pos-Graduacao em Engenharia de Producao, Universidade Paulista, R. Dr. Bacelar 1212, Cep 04026-002, Sao Paulo (Brazil)


    The quality and the power of human activities affect the external environment in different ways that can be measured and evaluated by means of several approaches and indicators. While the scientific community has been publishing several proposals for sustainable development indicators, there is still no consensus regarding the best approach to the use of these indicators and their reliability to measure sustainability. It is important, therefore, to question the effectiveness of sustainable development indicators in an effort to continue in the search for sustainability. This paper compares the results obtained with emergy accounting with five global Sustainability Metrics (SMs) proposed in the literature to verify if metrics are communicating coherent and similar information to guide decision makers towards sustainable development. Results obtained using emergy indices are discussed with the aid of emergy ternary diagrams. Metrics are confronted with emergy results, and the degree of variability among them is analyzed using a correlation matrix created for the Mercosur nations. The contrast of results clearly shows that metrics arrive at different interpretations about the sustainability of the nations studied, but also that some metrics may be grouped and used more prudently. Mercosur is presented as a case study to highlight and explain the discrepancies and similarities among Sustainability Metrics, and to expose the extent of emergy accounting.

  15. The Use of Biofuel for Sustainable Growth in Developing Countries (United States)

    Tsang, J.


    The biofuel industry is divided into four categories comprising of feedstocks used in 1st and 2nd generation bioethanol and biodiesel. In order to identify and quantify each biofuel feedstock's potential for sustainable growth, each were evaluated according to self-developed social, financial, and environmental criteria. From the investigation and analysis carried out, 1st generation biodiesel and bioethanol were determined to be feedstocks not capable of facilitating sustainable growth. Results showed low earnings before interest, taxes, depreciation and amortization (EBITDA) of -0.5 to 1 USD per gallon for biodiesel and 0.25 to 0.5 USD per gallon for bioethanol. Results also showed a poor return on asset (ROA). The energy required to produce one MJ of 1st generation biofuel fuel was at least 0.4 MJ, showing poor energy balance. Furthermore, high land, water, pesticide, and fertilizer requirements strained surrounding ecosystems by affecting the food web, thus reducing biodiversity. Over 55% of land used by the biodiesel industry in Indonesia and Malaysia involved the deforestation of local rainforests. This not only displaced indigenous organisms from their habitat and decreased their scope of nutrition, but also contributed to soil erosion and increased the probability of flooding. If left unregulated, imbalances in the ecosystem due to unsustainable growth will result in a permanent reshaping of tropical rainforest ecosystems in Southeast Asia. Algae, an example of 2nd generation biodiesel feedstock, was concluded to be the biofuel feedstock most capable of supporting sustainable growth. This is due to its low production costs of $1-1.5/gal, high biological productivity of 5000 gallons of biodiesel per acre per year, and high ROA of 25-35%. Additionally, algae's adaptability to varying environmental conditions also makes it an appealing candidate for businesses in developing countries, where access to resource supplies is unstable. Additionally, its reduced net

  16. Quantitative evaluation of masseter muscle volume in different growth patterns and its correlation with facial morphology: Cone beam computed tomography study


    Mukesh Gupta; P G Makhija


    Objective: This investigation was designed to evaluate the masseter muscle volume in different growth patterns and its correlation with facial morphology using three-dimensional cone beam computed tomography (CBCT), Materials and Methods: Study was conducted using CBCT scans of nonorthodontically treated individuals (n = 32, 19 males and 13 females) between the ages of 18–25 years. The masseter muscle volume was calculated using Dolphin 3D software 11.5 version (Essential Dental Products, New...


    Directory of Open Access Journals (Sweden)

    Bogdan Ion Boldea


    correlation between the explanatory variables and the country-specific effects. For a robustness assessment, we also apply the so-called GMM-System estimation. According to our results, an increase in the volatility of the social output (a decrease in the sustainability of the growth processes leads to a greater inequality in incomes distribution. Such outcome appears to be robust to the changes in estimation methodology


    Directory of Open Access Journals (Sweden)

    Ana-Maria Popescu (Stîngaciu


    Full Text Available Starting with general information about the EU multiannual financial framework and the European Union’s budget, the research paper attempts to respond to some questions of general interest regarding the activities financed through EU budget, the potential causes for a low absorption rate of funding in the current financing period and concludes with some measures needed to be taken to strengthen the absorption of funding for the next financing period, 2014-2020. Based on the main theme of the Europe 2020 strategy, smart, sustainable and inclusive growth, the article attempts to outline the important role of EU allocations for the period 2014-2020 for funding the growing number of policy in which EU can be more effective in the current context, after the economic and financial crisis. The paper presents the objectives of the Europe 2020 strategy and the targets for 2014-2020.

  19. Transient axonal glycoprotein-1 (TAG-1 and laminin-α1 regulate dynamic growth cone behaviors and initial axon direction in vivo

    Directory of Open Access Journals (Sweden)

    Yost H Joseph


    Full Text Available Abstract Background How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood. We have taken advantage of the unique features of the zebrafish embryo to visualize dynamic growth cone behaviors and analyze guidance mechanisms of axons emerging from a central brain nucleus in vivo. Results We investigated axons of the nucleus of the medial longitudinal fascicle (nucMLF, which are the first axons to extend in the zebrafish midbrain. Using in vivo time-lapse imaging, we show that both positive axon-axon interactions and guidance by surrounding tissue control initial nucMLF axon guidance. We further show that two guidance molecules, transient axonal glycoprotein-1 (TAG-1 and laminin-α1, are essential for the initial directional extension of nucMLF axons and their subsequent convergence into a tight fascicle. Fixed tissue analysis shows that TAG-1 knockdown causes errors in nucMLF axon pathfinding similar to those seen in a laminin-α1 mutant. However, in vivo time-lapse imaging reveals that while some defects in dynamic growth cone behavior are similar, there are also defects unique to the loss of each gene. Loss of either TAG-1 or laminin-α1 causes nucMLF axons to extend into surrounding tissue in incorrect directions and reduces axonal growth rate, resulting in stunted nucMLF axons that fail to extend beyond the hindbrain. However, defects in axon-axon interactions were found only after TAG-1 knockdown, while defects in initial nucMLF axon polarity and excessive branching of nucMLF axons occurred only in laminin-α1 mutants. Conclusion These results demonstrate how two guidance cues, TAG-1 and laminin-α1, influence the behavior of growth cones during axon pathfinding in vivo. Our data suggest that TAG-1 functions to allow growth cones to sense environmental cues and mediates positive axon-axon interactions. Laminin-α1 does not regulate

  20. Examining the contradiction in 'sustainable urban growth': an example of groundwater sustainability (United States)

    Zellner, Moira L.; Reeves, Howard W.


    The environmental planning literature proposes a set of 'best management practices' for urban development that assumes improvement in environmental quality as a result of specific urban patterns. These best management practices, however, often do not recognise finite biophysical limits and social impacts that urban patterns alone cannot overcome. To shed light on this debate, we explore the effects of different degrees of urban clustering on groundwater levels using a coupled land-use change and groundwater-flow model. Our simulations show that specific urban forms only slow down the impact on groundwater. As population increases, the pattern in which it is accommodated ceases to matter, and widespread depletion ensues. These results are predictable, yet current planning practice tends to take growth for granted and is reluctant to envision either no-growth scenarios or the prospect of depletion. We propose to use simulations such as those presented here to aid in policy discussions that allow decision makers to question the assumption of sustainable growth and suggest alternative forms of development.

  1. Sustainable Mineral-Intensive Growth in Odisha, India (United States)

    Nayak, S.


    The focus of the work is to highlight the present environmental and social impacts of extensive mining on the health of the common people of Odisha. The mining activities have created havoc impact to the environment and social life of the state. Odisha has huge deposits of ores and minerals of chromite, nickel, bauxite, iron, coal, copper, manganese, graphite, vanadium etc. The mining activities have encouraged rapid urbanization and at the same time have altered the topography of these areas and extensively degraded the forest land. For long term sustainable development of the society, it is necessary to take a balanced and integrated approach towards environmental protection and economic advancement. Industries should aim at achieving their goals, through a system of permits based on best available techniques, which gives emphasis on integrated prevention and control of consumption of energy and water as well as pollution of water, air and soil. The rapid industrial growth has brought promising opportunities for economic development and poverty reduction in Odisha but at the same time has caused extensive environmental degradation. The best management practices to deal with environmental and social impacts on mineral-intensive growth are suggested in this work. In addition to lean technology, economic implications of the introduction of environmental technologies for mining activities are also discussed.

  2. Sustainable de-growth: Mapping the context, criticisms and future prospects of an emergent paradigm

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Alier, Joan [Department of Economics and Economic History, Universidad Autonoma de Barcelona (Spain); Pascual, Unai [Department of Land Economy, University of Cambridge (United Kingdom); Vivien, Franck-Dominique [Department of Economics, Universite de Reims Champagne Ardenne (France); Zaccai, Edwin [Institute for Environmental Management and Land Planning, Universite Libre de Bruxelles (Belgium)


    'Sustainable de-growth' is both a concept and a social-grassroots (Northern) movement with its origins in the fields of ecological economics, social ecology, economic anthropology and environmental and social activist groups. This paper introduces the concept of sustainable de-growth by mapping some of the main intellectual influences from these fields, with special focus on the Francophone and Anglophone thinking about this emergent notion. We propose hypotheses pertaining to the appeal of sustainable de-growth, and compare it to the messages enclosed within the dominant sustainable development idea. We scrutinize the theses, contradictions, and consequences of sustainable de-growth thinking as it is currently being shaped by a heterogeneous body of literature and as it interacts with an ample and growing corpus of social movements. We also discuss possible future paths for the de-growth movement compared to the apparent weakening of the sustainable development paradigm. (author)

  3. The impact of the quality of coal mine stockpile soils on sustainable vegetation growth and productivity

    CSIR Research Space (South Africa)

    Mushia, NM


    Full Text Available , chemical, and biological properties, limiting their capability for sustainable vegetation growth. The aim of the study was to evaluate the impact of stockpile soils of differing depth and quality on vegetation growth and productivity. Soils were collected...

  4. Real effects of government debt on sustainable economic growth in Malaysia

    Directory of Open Access Journals (Sweden)

    Muhammad Danial Ariff Burhanudin


    Full Text Available The persistent increase of government debt in Malaysia in the recent years has raised con-cerns as to whether the borrowings have spurred the economy or became a drag on econom-ic growth. The present paper investigates the real effect of government debt on sustainable economic growth in Malaysia using the Autoregressive Distributed Lag approach for the period of 1970-2015. The results show there are positive significant long- and short-run relationships between government debt and sustainable economic growth. There is also a unidirectional causality running from government debt to sustainable economic growth. The findings indicate that Malaysia’s government debt is an important macroeconomic element for sustainability of economic growth in Malaysia. There is no evidence, however, to con-clude that the level of government debt had any adverse impacts on sustainable economic growth.

  5. Surface Orientation Affects the Direction of Cone Growth by Leptolyngbya sp. Strain C1, a Likely Architect of Coniform Structures Octopus Spring (Yellowstone National Park) (United States)

    Reyes, Kristina; Gonzalez, Nicolas I.; Stewart, Joshua; Ospino, Frank; Nguyen, Dickie; Cho, David T.; Ghahremani, Nahal; Spear, John R.


    Laminated, microbially produced stromatolites within the rock record provide some of the earliest evidence for life on Earth. The chemical, physical, and biological factors that lead to the initiation of these organosedimentary structures and shape their morphology are unclear. Modern coniform structures with morphological features similar to stromatolites are found on the surface of cyanobacterial/microbial mats. They display a vertical element of growth, can have lamination, can be lithified, and observably grow with time. To begin to understand the microbial processes and interactions required for cone formation, we determined the phylogenetic composition of the microbial community of a coniform structure from a cyanobacterial mat at Octopus Spring, Yellowstone National Park, and reconstituted coniform structures in vitro. The 16S rRNA clone library from the coniform structure was dominated by Leptolyngbya sp. Other cyanobacteria and heterotrophic bacteria were present in much lower abundance. The same Leptolyngbya sp. identified in the clone library was also enriched in the laboratory and could produce cones in vitro. When coniform structures were cultivated in the laboratory, the initial incubation conditions were found to influence coniform morphology. In addition, both the angle of illumination and the orientation of the surface affected the angle of cone formation demonstrating how external factors can influence coniform, and likely, stromatolite morphology. PMID:23241986

  6. Surface orientation affects the direction of cone growth by Leptolyngbya sp. strain C1, a likely architect of coniform structures Octopus Spring (Yellowstone National Park). (United States)

    Reyes, Kristina; Gonzalez, Nicolas I; Stewart, Joshua; Ospino, Frank; Nguyen, Dickie; Cho, David T; Ghahremani, Nahal; Spear, John R; Johnson, Hope A


    Laminated, microbially produced stromatolites within the rock record provide some of the earliest evidence for life on Earth. The chemical, physical, and biological factors that lead to the initiation of these organosedimentary structures and shape their morphology are unclear. Modern coniform structures with morphological features similar to stromatolites are found on the surface of cyanobacterial/microbial mats. They display a vertical element of growth, can have lamination, can be lithified, and observably grow with time. To begin to understand the microbial processes and interactions required for cone formation, we determined the phylogenetic composition of the microbial community of a coniform structure from a cyanobacterial mat at Octopus Spring, Yellowstone National Park, and reconstituted coniform structures in vitro. The 16S rRNA clone library from the coniform structure was dominated by Leptolyngbya sp. Other cyanobacteria and heterotrophic bacteria were present in much lower abundance. The same Leptolyngbya sp. identified in the clone library was also enriched in the laboratory and could produce cones in vitro. When coniform structures were cultivated in the laboratory, the initial incubation conditions were found to influence coniform morphology. In addition, both the angle of illumination and the orientation of the surface affected the angle of cone formation demonstrating how external factors can influence coniform, and likely, stromatolite morphology.


    Directory of Open Access Journals (Sweden)

    Alina MĂRCUTĂ


    Full Text Available This paper intends to analyse the correlation between the level of economic growth of a country and its rural development. The phrase sustainable development combines the economic growth and the preservation and improvement of environmental and human health, preservation of social justice and assurance of democratic environment in social life. Therefore, the sustainable economic growth provides for the meeting of current consumption requirements without compromising or prejudicing those of the future generations. By adding the requirements regarding environmental protection and preservation of natural resources to economic growth we may speak of a proper sustainable development.

  8. Making long-term economic growth more sustainable. Evaluating the costs and benefits

    Energy Technology Data Exchange (ETDEWEB)

    Islam, Sardar M.N.; Clarke, Matthew [Sustainable Economic Growth Program, Centre for Strategic Economic Studies, City Campus, Victoria University, PO Box 14428, Melbourne, Vic. (Australia); Munasinghe, Mohan [Munasinghe Institute for Development (MIND), Colombo (Sri Lanka)


    Currently, traditional development issues such as economic stagnation, poverty, hunger, and illness as well as newer challenges like environmental degradation and globalisation demand attention. Sustainable development, including its economic, environmental and social elements, is a key goal of decisionmakers. Optimal economic growth has also been a crucial goal of both development theorists and practitioners. This paper examines the conditions under which optimal growth might be sustainable, by assessing the costs and benefits of growth. Key environmental and social aspects are considered. The Ecol-Opt-Growth-1 model analyses economic-ecological interactions, including resource depletion, pollution, irreversibility, other environmental effects, and uncertainty. It addresses some important issues, including savings, investment, technical progress, substitutability of productive factors, intergenerational efficiency, equity, and policies to make economic growth more sustainable-a basic element of the sustainomics framework. The empirical results support growing concerns that costs of growth may outweigh its benefits, resulting in unsustainability. Basically, in a wide range of circumstances, long term economic growth is unsustainable due to increasing environmental damage. Nevertheless, the model has many options that can be explored by policy makers, to make the development path more sustainable, as advocated by sustainomics. One example suggests that government supported abatement programs are needed to move towards sustainable development, since the model runs without abatement were infeasible. The optimal rate of abatement increases over time. Abatement of pollution is necessary to improve ecosystem viability and increase sustainability. Further research is necessary to seek conditions under which alternative economic growth paths are likely to become sustainable.

  9. EMODnet MedSea Checkpoint for sustainable Blue Growth (United States)

    Moussat, Eric; Pinardi, Nadia; Manzella, Giuseppe; Blanc, Frederique


    The EMODNET checkpoint is a wide monitoring system assessment activity aiming to support the sustainable Blue Growth at the scale of the European Sea Basins by: 1) Clarifying the observation landscape of all compartments of the marine environment including Air, Water, Seabed, Biota and Human activities, pointing out to the existing programs, national, European and international 2) Evaluating fitness for use indicators that will show the accessibility and usability of observation and modeling data sets and their roles and synergies based upon selected applications by the European Marine Environment Strategy 3) Prioritizing the needs to optimize the overall monitoring Infrastructure (in situ and satellite data collection and assembling, data management and networking, modeling and forecasting, geo-infrastructure) and release recommendations for evolutions to better meet the application requirements in view of sustainable Blue Growth The assessment is designed for : - Institutional stakeholders for decision making on observation and monitoring systems - Data providers and producers to know how their data collected once for a given purpose could fit other user needs - End-users interested in a regional status and possible uses of existing monitoring data Selected end-user applications are of paramount importance for: (i) the blue economy sector (offshore industries, fisheries); (ii) marine environment variability and change (eutrophication, river inputs and ocean climate change impacts); (iii) emergency management (oil spills); and (iv) preservation of natural resources and biodiversity (Marine Protected Areas). End-user applications generate innovative products based on the existing observation landscape. The fitness for use assessment is made thanks to the comparison of the expected product specifications with the quality of the product derived from the selected data. This involves the development of checkpoint information and indicators based on Data quality and

  10. Repulsive axon guidance cues ephrin-A2 and slit3 stop protrusion of the growth cone leading margin concurrently with inhibition of ADF/cofilin and ERM proteins. (United States)

    Marsick, Bonnie M; Roche, Florence K; Letourneau, Paul C


    Axonal growth cones turn away from repulsive guidance cues. This may start with reduced protrusive motility in the region the growth cone leading margin that is closer to the source of repulsive cue. Using explants of E7 chick temporal retina, we examine the effects of two repulsive guidance cues, ephrin-A2 and slit3, on retinal ganglion cell growth cone protrusive activity, total F-actin, free F-actin barbed ends, and the activities (phosphorylation states) of actin regulatory proteins, ADF/cofilin and ezrin, radixin, moesin (ERM) proteins. Ephrin-A2 rapidly stops protrusive activity simultaneously with reducing F-actin, free barbed ends and the activities of ADF/cofilin and ERM proteins. Slit3 also stops protrusion and reduces the activities of ADF/cofilin and ERM proteins. We interpret these results as indicating that repulsive guidance cues inhibit actin polymerization and actin-membrane linkage to stop protrusive activity. Retrograde F-actin flow withdraws actin to the C-domain, where F-actin bundles interact with myosin II to generate contractile forces that can collapse and retract the growth cone. Our results suggest that common mechanisms are used by repulsive guidance cue to disable growth cone motility and remodel growing axon terminals. Copyright © 2012 Wiley Periodicals, Inc.

  11. Between green growth and degrowth: Decoupling, rebound effects and the politics for long-term sustainability

    DEFF Research Database (Denmark)

    Nørgaard, Jørgen; Xue, Jin


    that the rebound effect is both a natural consequence of the growth dedicated society and a driver of further economic growth. Through rebound effects, labour productivity and eco-efficiency technologies in the growth society tend to contradict the goal of achieving environmental sustainability. To address...

  12. Export growth, energy costs, and sustainable supply chains (United States)


    The report examines sustainable supply chains in North America and the role played by rail intermodal : operations in lowering ten-mile fuel and emission costs. It examines whether current systems favor imports : over exports a current complaint ...

  13. Effects of artemisinin sustained-release granules on mixed alga growth and microcystins production and release. (United States)

    Ni, Lixiao; Li, Danye; Hu, Shuzhen; Wang, Peifang; Li, Shiyin; Li, Yiping; Li, Yong; Acharya, Kumud


    To safely and effectively apply artemisinin sustained-release granules to control and prevent algal water-blooms, the effects of artemisinin and its sustained-release granules on freshwater alga (Scenedesmus obliquus (S. obliquus) and Microcystis aeruginosa (M. aeruginosa)), as well as the production and release of microcystins (MCs) were studied. The results showed that artemisinin sustained-release granules inhibited the growth of M. aeruginosa (above 95% IR) and S. obliquus (about 90% IR), with M. aeruginosa more sensitive. The artemisinin sustained-release granules had a longer inhibition effect on growth of pure algae and algal coexistence than direct artemisinin dosing. The artemisinin sustained-release granules could decrease the production and release of algal toxins due to the continued stress of artemisinin released from artemisinin sustained-release granules. There was no increase in the total amount of MC-LR in the algal cell culture medium.

  14. A Systems Model to Make, Market, and Lead Your Way towards Sustained Growth

    National Research Council Canada - National Science Library

    Raman Kumar Agrawalla


    .... Marketing is a key business function to market and lead a business towards sustained profitable growth but the problem is it lacks a systems perspective in its operations, strategy, and practice...

  15. An Integrated Diagnostic Framework to Manage Organization Sustainable Growth: An Empirical Case

    National Research Council Canada - National Science Library

    Jingxiao Zhang; Klaus Schmidt; Hui Li


      This research aims to develop a quantitative diagnostic framework by combining the Weisbord six-box model with the growth management model to focus on an organization's internally driven sustainable management system...

  16. Pro-Poor Growth and Social Policy Approaches to Sustainable ...

    African Journals Online (AJOL)

    One of the intriquing paradoxes for most developing countries including Nigeria is the rising rate of low human development indices. This study is a critical examination of human welfare issues and human development indices as a parameter for sustainable development in Nigeria. The paper contends that one major issue ...

  17. A volume change index for forest growth and sustainability (United States)

    Paul Van Deusen; Francis Roesch


    A volume change index is suggested that is derived from growth components that can be estimated from remeasured plots. The new index incorporates more information than the traditional growth over removals, ratio. The new index directly indicates whether the standing volume will be increasing or decreasing if current conditions persist, whereas the ratio of...

  18. Economics of Sustainable Development. Competitiveness and Economic Growth

    Directory of Open Access Journals (Sweden)

    Dorel AILENEI


    Full Text Available Economic growth is one of the most important issues of humanity. Both in national economies and world economy, recession and prosperity periods are regularly succeeding with different amplitudes. But beyond these fluctuations and their effects, the results are important: performance and economic growth. Because of the problematical issue of economic growth, the authors are trying to critically reflect on the economic growth concept and on its implications on the praxis area. Although there is a large literature about economic growth modeling, it is intriguing that there still are some serious obstacles for conceptualization and praxis. Only the simple fact that the economic growth process needs serious thinking on the time dimension is sufficient for understanding the real difficulties of this problematical issue. As for the economic growth praxis, a clear analysis of the interests system within an economy is needed. Without trying to find miraculous solutions for the economic growth issue, the authors suggest a clear and correct analysis of this important subject.

  19. Quantitative evaluation of masseter muscle volume in different growth patterns and its correlation with facial morphology: Cone beam computed tomography study

    Directory of Open Access Journals (Sweden)

    Mukesh Gupta


    Full Text Available Objective: This investigation was designed to evaluate the masseter muscle volume in different growth patterns and its correlation with facial morphology using three-dimensional cone beam computed tomography (CBCT, Materials and Methods: Study was conducted using CBCT scans of nonorthodontically treated individuals (n = 32, 19 males and 13 females between the ages of 18–25 years. The masseter muscle volume was calculated using Dolphin 3D software 11.5 version (Essential Dental Products, New Delhi, India. The subjects were grouped according to growth pattern and facial form. Conclusion: CBCT predicts actual muscle volume by calculating number of voxels of scan data and exact geometry of the muscle. The mean masseter muscle volume was 28.73 ± 5.51 cm3 for horizontal growth patterns, 27.30 ± 6.49 cm3 for average growth pattern, and 22.14 ± 3.25 cm3 for vertical growth pattern. The individuals with thin masseter morphology had a longer face in proportion/relation to their facial width with an increase in masseter muscle volume, the facial index decreased, and face appeared to be more rectangular. Euryprosopic facial form showed maximum/highest masseter muscle volume, whereas leptoprosopic facial form showed least muscle volume.

  20. Microfoundations for Sustainable Growth with Eco-Intelligent Product Service-Arrangements

    Directory of Open Access Journals (Sweden)

    Najine Ameli


    Full Text Available This paper argues that the contemporary growth paradigm needs to be reconsidered on a micro level of consumption and product service-systems. This becomes necessary since a dynamic link between macro strategies and micro implementation of sustainable growth is missing up to date. Therefore, mainstream sustainability strategies of efficiency and consistency are extended by sufficiency in order to integrate strategies for individual welfare within their social environment. Limits to and drivers for growth are revised and updated socially in terms of qualitative values, diminishing marginal utility or symbolic social distinction. We elaborate a definition of sustainable growth that fosters individual welfare by enhancing social enactment within the boundaries of environmental space. Shifting focus on social aspects in design fosters more sustainable production and consumption patterns while sustaining individual welfare. We derive latent indications for eco-intelligent product service-arrangements and evaluate to concepts by referring to introduced definitions and according indications. With doing so, we illustrate new pathways for the translation of sustainable growth and strategies into product service-systems.


    Directory of Open Access Journals (Sweden)

    Victor N. ITUMO


    Full Text Available Nigeria is currently facing economic growth and development challenge. The economic challenge is occasioned by mono-cultural economic reliance on the single resource of crude oil export revenue as well as other internal and international effects that affect her economic drive for heightened growth and development. The Nigerian government had over the years searched for ways of diversifying its economy for greater growth and development especially given the various challenges in the economy, mainly the steep reduction in crude oil revenue arising from volatility of global oil price. This paper therefore uses the research methodology of case study to do a holistic assessment of the possibility of Nigeria diversifying into her tourism potentials for economic growth and development. This would be done equally by drawing relevant comparative analysis of other countries bringing economic benefits in Africa and across the globe.

  2. Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice

    National Research Council Canada - National Science Library

    Williams, Scott E; Garcia, Idoia; Crowther, Andrew J; Li, Shiyi; Stewart, Alyssa; Liu, Hedi; Lough, Kendall J; O'Neill, Sean; Veleta, Katherine; Oyarzabal, Esteban A; Merrill, Joseph R; Shih, Yen-Yu Ian; Gershon, Timothy R


    .... Here, we report that Aspm, a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports the growth of medulloblastoma, the most common malignant pediatric brain tumor...

  3. The Potential Role of Innovative Indian SMEs in Sustainable Growth


    Ionica Oncioiu; Florentina Raluca Bîlcan; Anca Gabriela Petrescu


    India has experienced a robust economic growth in the recent years, but with a trajectory which offers both positive and negative lessons on the business innovation faced by many countries in Asia and elsewhere in the developing world. This study sought to test the relationship between innovation, financial performance and economic growth. Data were analyzed using descriptive and inferential statistics on the factors that contribute to assuring the innovation of the processes invo...

  4. A Systems Model to Make, Market, and Lead Your Way towards Sustained Growth

    Directory of Open Access Journals (Sweden)

    Raman Kumar Agrawalla


    Full Text Available Business enterprises exist in a world that is fiercely competitive, tied with huge global uncertainties. They always encounter increasing pressure on prices and margins. Hence, irrespective of their domain of operations and industry, businesses are naturally concerned about their growth, specifically sustained profitable growth, in today’s world. Marketing is a key business function to market and lead a business towards sustained profitable growth but the problem is it lacks a systems perspective in its operations, strategy, and practice. Further, given the confluence and systemic interactions of various economic, digital, and competitive forces; the challenge for different business functions—including marketing—increases tremendously. In this context, it is important for business enterprises to have a systems perspective to find their ways to growth that will be sustained. This calls for a holistic approach to assimilate and steer the business functions in any enterprise. The present conceptual paper focuses on an important business function for sustained growth in a holistic way and presents a systems model, called ‘Value Based Business Approach (VBBA-marketing’, which has potential to guide and steer companies and business enterprises to create a path for their sustained profitable growth.


    Directory of Open Access Journals (Sweden)

    Mihut Ioana


    Full Text Available What is economic growth? Although the answer to this question may seems of real simplicity, developing an accurate definition of this concept may constitute a real challenge both from a theoretical but also empirical point of view. This constant debate upon the concept of economic growth as well as indentifying the optimum set of instruments for quantifying it, constituted the starting point of the current article. The concept of economic growth is used nowadays complementary to terms like economic development, economic welfare or economic progress with reference to this complex process that implies macro-scale structures. Moreover indentifying the main factors that generate a significant impact upon the dynamics of the economic growth process, constitute a useful approach taking into consideration the high degree of heterogeneity that characterize the architecture of the economies around the world. If we develop this analysis across the European Union member states this debate became even more challenging due to the high degree of diversity that characterize these economies. Moreover, the Central and Eastern European countries and especially the ones that joined EU in 2004 and 2007 embody a set of particularities that make them extremely different from the rest of the European Union member states, features related to the historical background, economic policies and common efforts to intensify the convergence process with the more developed EU members. This paper studies the impact of two main factors upon the economic growth process namely an endogenous-exogenous factor like the degree of openness and an endogenous factor like the human capital using a complex dynamic panel method. The arguments that were in favour of choosing this two factors are on one hand the multitude of theoretical studies that argued the importance of them in modelling the economic growth process and on the other hand the small number of studies that use panel methods in

  6. An Approach to Assess the Effectiveness of Smart Growth in Achieving Sustainable Development

    Directory of Open Access Journals (Sweden)

    Ishak Mohammed


    Full Text Available Smart Growth has become an evident concept in public policy debates and provides answers to the enduring problems of sprawling development and its many adverse consequences. While the concept has widely been touted to promote an urban development pattern characterized by compact and mixed-use development, walkable and bikeable neighborhoods, preserved green spaces, and the availability of mass transit, not much has been written about its contribution to sustainable development. This paper is an attempt to explore the concepts of smart growth and sustainable development and the extent to which the former contributes to the achievement of the latter. The various debates surrounding the smart growth movement have also been explored. The 2003 general plan guideline by the US State of California is used as the basis for determining the sustainable development role of smart growth policies in Portland (Oregon, Arlington (Virginia, Boulder (Colorado and Lancaster County (Pennsylvania. The paper concludes that it would be inappropriate to equate smart growth to sustainable development as the latter is a much broader concept and cuts across myriad disciplines. Notwithstanding, the implementation of smart growth policies in the cases studied have been observed to promote compact, infill and transit-oriented development and to conserve and protect open spaces and natural areas. All these are pro-sustainable development. While this paper has observed that smart growth serves as one of the approaches for achieving sustainable development goals, it calls for a more quantitative study to be able to measure the magnitude of the contribution associated with the smart growth policies.

  7. Promoting Sustainable Economic Growth in Mexico (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    Watson, A.; Butheau, M.; Sandor, D.


    Mexico is the second largest economy in Latin America, with rapid growth occurring in the industrial and services sectors. A forward-thinking country on climate change, the nation recognizes that the threat of higher temperatures, changes in precipitation patterns, and more frequent weather-related disasters could pose a substantial risk to its expanding economy.

  8. Urban growth management and ecological sustainability: confronting the "smart growth" fallacy (United States)

    Gabor Zovanyi


    Growth management and Smart Growth initiatives in the United States represent an ongoing process of growth accommodation. Because growth by definition constitutes unsustainable behavior in that it is incapable of being continued or maintained indefinitely, ongoing growth accommodation must be recognized as activity incongruous with advancing the goal of ecological...

  9. Is the growth stimulation by low doses of glyphosate sustained over time?

    Energy Technology Data Exchange (ETDEWEB)

    Cedergreen, Nina [Department of Agricultural Sciences, Faculty of Life Science, University of Copenhagen, Hojbakkegard Alle 13, 2630 Tastrup (Denmark)], E-mail:


    The herbicide, glyphosate, has been shown to stimulate growth in a range of species when applied at doses of 5-60 g a.e. ha{sup -1}, corresponding to realistic spray drift events. This study investigates growth of shoot parameters over time to detect whether the glyphosate induced growth increase was sustained and had a final effect on reproduction. The results showed that an actual biomass growth rate increase took place within the first week after spraying with glyphosate doses <60 g a.e. ha{sup -1}. This initial growth boost kept treated plants larger than untreated plants for up to six weeks, but at harvest there was no significant difference between control plants and treated plants. Possible effects of glyphosate hormesis on the competitive ability of spray drift affected plants are discussed. - Glyphosate induced hormesis in barley is not sustained over time.

  10. The Potential Role of Innovative Indian SMEs in Sustainable Growth

    Directory of Open Access Journals (Sweden)

    Ionica Oncioiu


    Full Text Available India has experienced a robust economic growth in the recent years, but with a trajectory which offers both positive and negative lessons on the business innovation faced by many countries in Asia and elsewhere in the developing world. This study sought to test the relationship between innovation, financial performance and economic growth. Data were analyzed using descriptive and inferential statistics on the factors that contribute to assuring the innovation of the processes involved in the financial performance and economic development in the rubber and plastic product sector in India. The results revealed that there is a positive relationship between innovation and economic growth, as well as between innovation and the financial performance of the company. Finally, the conclusion presents implications, limitations and directions for future research regarding the importance of innovation to the firm’s performance. A clear lesson from this study is that the future must include promoting Innovative Indian SMEs; in other words, business competitiveness depends on the creativity and innovativeness of its entrepreneurship.

  11. Genetically Modified Crops: Towards Agricultural Growth, Agricultural Development, or Agricultural Sustainability?


    Azadi, Hossein; Ghanian, Mansour; Ghuchani, Omid M.; Rafiaani, Parisa; Taning, Clauvis N. T.; Hajivand, Roghaye Y.; Dogot, Thomas


    The present debate on how to increase global food production in a sustainable way has focused on arguments over the pros and cons of genetically modified (GM) crops. Scientists in both public and private sectors clearly regard GM technology as a major new set of tools, whereas industry sees it as an opportunity for increased profits. However, it remains questionable whether GM crops can contribute to agricultural growth, agricultural development, and agricultural sustainability. This review p...

  12. Critical Sustainability: Setting the Limits to Growth and Responsibility in Tourism

    Directory of Open Access Journals (Sweden)

    Jarkko Saarinen


    Full Text Available The idea of sustainable development has been discussed in tourism research for almost a quarter of a century. During that time, sustainability has become an important policy framework for tourism and regional developers guiding their planning and development thinking. Sustainability has also emerged academically as an important field of research with an emphasis on defining the limits to growth and responsibilities in tourism. However, while there are urgent needs to incorporate sustainability into tourism, there is also a growing amount of frustration among scholars on the conceptual nature of sustainability and how tourism as a private-driven economic activity relates to the ideals of sustainable development. This has created an increasing need to understand and potentially reframe the concept. The purpose of this paper is to overview the conceptual dimensions of sustainable tourism and discuss some of the main sources of frustration. Based on this, it is concluded that while a conceptual plurality seems to be unavoidable, there is a need to re-frame i.e., rescale and decentralize tourism in policy frameworks and practices aiming towards sustainability.

  13. Parasitic chytrids sustain zooplankton growth during inedible algal bloom. (United States)

    Rasconi, Serena; Grami, Boutheina; Niquil, Nathalie; Jobard, Marlène; Sime-Ngando, Télesphore


    This study assesses the quantitative impact of parasitic chytrids on the planktonic food web of two contrasting freshwater lakes during different algal bloom situations. Carbon-based food web models were used to investigate the effects of chytrids during the spring diatom bloom in Lake Pavin (oligo-mesotrophic) and the autumn cyanobacteria bloom in Lake Aydat (eutrophic). Linear inverse modeling was employed to estimate undetermined flows in both lakes. The Monte Carlo Markov chain linear inverse modeling procedure provided estimates of the ranges of model-derived fluxes. Model results confirm recent theories on the impact of parasites on food web function through grazers and recyclers. During blooms of "inedible" algae (unexploited by planktonic herbivores), the epidemic growth of chytrids channeled 19-20% of the primary production in both lakes through the production of grazer exploitable zoospores. The parasitic throughput represented 50% and 57% of the zooplankton diet, respectively, in the oligo-mesotrophic and in the eutrophic lakes. Parasites also affected ecological network properties such as longer carbon path lengths and loop strength, and contributed to increase the stability of the aquatic food web, notably in the oligo-mesotrophic Lake Pavin.


    Directory of Open Access Journals (Sweden)

    B. S. TAN


    Full Text Available The environmental impact of the commercial aviation industry for an emerging economy like Malaysia is under-studied. The focus on the subject has thus far concentrated either on non geographical performance of the aviation industry or technical performance of aircrafts and that leaves the sustainability of the commercial aviation industry for an economy, or more specifically, an emerging economy least understood. Hence, this paper aims to investigate the sustainability of the growth of the commercial aviation industry in Malaysia and its impact upon the environment using a system dynamics approach. VENSIM is employed to model the commercial aviation industry in Malaysia as a dynamic system to evaluate the CO2 emitted from each component within the industry in order to forecast its overall CO2 emission. Results from the analysis show that sustainable growth can be affected by adopting short and long term strategies identified in this study.

  15. In Tourism Industry We Talk About Sustainable Development, But We Evaluate Profits and Growth

    Directory of Open Access Journals (Sweden)

    Sirk Tanja


    Full Text Available Tourism is one of the biggest economic sectors, it has a significant impact on the environment. At the same time, the long-term development of tourism also greatly depends on the environment it affects. Experts are unanimous that it is necessary for the longterm existence and development of tourism that it becomes sustainable. Nevertheless, in tourism businesses, sustainable development strategies are not sufficiently present and put into practice. The author of the article presents the argument as a possible reason for this: the management of tourism enterprises as well as management of all the companies is focused on doing business successfully; and because the performance of management is assessed in terms of growth and security of its operations, and not in relation to the measures taken in the field of sustainable development, management gives priority to ensuring relatively short-term growth and security of operations.

  16. Characterizing Stand Structure and Growth of Natural Beech Forests for the Development of Sustainable Forest Practices

    DEFF Research Database (Denmark)

    Ghalandarayeshi, Shaaban

    forests in northern Iran lack such scientific foundation. The objective of the present study is to assist in this process by characterizing growth and stand structure of oriental beech for a range of growing conditions in northern Iran and to provide useful insight for application in sustainable...

  17. Sales Forecasting in the Context of Seasonal Activities and Company Sustainable Growth

    Directory of Open Access Journals (Sweden)

    Ion Stancu


    Full Text Available The paper presents the use of the “time series model” to forecast the quarterly and yearly sales for a company with business seasonality. These sales forecasts will represent the fundamental basis for estimating the external financing, using the percentage to sales method. Sales growth rates are afterwards analysed in the context of ensuring a sustainable and self-financed growth. We focus on establishing the forecasted financial structure of the external financial requirements both in the context of using the reinvested profit complemented with credit, maintaining the debt rate constant, and in the context of total internal funding of the company economic growth, from reinvested profit.

  18. Ecological network analysis for economic systems: growth and development and implications for sustainable development. (United States)

    Huang, Jiali; Ulanowicz, Robert E


    The quantification of growth and development is an important issue in economics, because these phenomena are closely related to sustainability. We address growth and development from a network perspective in which economic systems are represented as flow networks and analyzed using ecological network analysis (ENA). The Beijing economic system is used as a case study and 11 input-output (I-O) tables for 1985-2010 are converted into currency networks. ENA is used to calculate system-level indices to quantify the growth and development of Beijing. The contributions of each direct flow toward growth and development in 2010 are calculated and their implications for sustainable development are discussed. The results show that during 1985-2010, growth was the main attribute of the Beijing economic system. Although the system grew exponentially, its development fluctuated within only a small range. The results suggest that system ascendency should be increased in order to favor more sustainable development. Ascendency can be augmented in two ways: (1) strengthen those pathways with positive contributions to increasing ascendency and (2) weaken those with negative effects.

  19. Tragedy of the Commons, Business Growth and the Fundamental Sustainability Problem

    Directory of Open Access Journals (Sweden)

    Edward J. Garrity


    Full Text Available This paper reviews the major issues involved in Hardin’s [1] tragedy of the commons, written over 44 years ago, and examines whether these issues are still relevant today. We assert that this model still provides important insight to aid in the solution to our global problems. In particular, we maintain that the underlying issues of growth against limits and bounded rationality are still not adequately recognized and addressed; this underlies many of the reasons for our unsustainable world. Examples from fisheries management are used to examine potential solutions and reveal weaknesses in current approaches. We show how our current, restricted mental models promote social injustice and blind us to developing sustainable solutions. Both the neo-liberal economic view of business that directly seeks growth and the new sustainable development view that indirectly supports growth are leading our global economy in the wrong direction and away from prosperity and sustainability. Current thinking has not realized Hardin’s message that sustainability is of the class of no technology solution problems. We conclude with recommendations to radically advance a new world view and business paradigm.

  20. Avoiding the Limits to Growth: Gross National Happiness in Bhutan as a Model for Sustainable Development

    Directory of Open Access Journals (Sweden)

    Jeremy S. Brooks


    Full Text Available In their 30-year update to Limits to Growth, Meadows et al. call for a vision of sustainable development that includes systemic change brought on by new perspectives on the purpose of development, new ways of measuring progress, and changes in social norms. Here, I discuss Meadows et al.’s work in the context of the literature on sustainable development and well-being as well as the development trajectory of Bhutan. I suggest that Bhutan’s development approach mirrors Meadows et al.’s recommendations and provides one model for sustainable development. The ideal of maximizing Gross National Happiness (GNH exemplifies Bhutan’s commitment to holistic development and dovetails with arguments about the shortcomings of approaches that emphasize economic growth. I provide examples of how GNH has been put into practice, describe how happiness is being measured, and discuss the emergence of social norms and a shared Bhutanese identity that may contribute to sustainable development. Bhutan’s development success suggests that an alternative to growth-centric development is viable. However, while Bhutan’s standard of living has increased, the country faces challenges, the most important of which may be their ability to manage rising consumption levels. Importantly, other nations have begun measuring well-being and considering similar development approaches.

  1. Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome. (United States)

    Mauriac, Stephanie A; Hien, Yeri E; Bird, Jonathan E; Carvalho, Steve Dos-Santos; Peyroutou, Ronan; Lee, Sze Chim; Moreau, Maite M; Blanc, Jean-Michel; Geyser, Aysegul; Medina, Chantal; Thoumine, Olivier; Beer-Hammer, Sandra; Friedman, Thomas B; Rüttiger, Lukas; Forge, Andrew; Nürnberg, Bernd; Sans, Nathalie; Montcouquiol, Mireille


    Mutations in GPSM2 cause Chudley-McCullough syndrome (CMCS), an autosomal recessive neurological disorder characterized by early-onset sensorineural deafness and brain anomalies. Here, we show that mutation of the mouse orthologue of GPSM2 affects actin-rich stereocilia elongation in auditory and vestibular hair cells, causing deafness and balance defects. The G-protein subunit Gαi3, a well-documented partner of Gpsm2, participates in the elongation process, and its absence also causes hearing deficits. We show that Gpsm2 defines an ∼200 nm nanodomain at the tips of stereocilia and this localization requires the presence of Gαi3, myosin 15 and whirlin. Using single-molecule tracking, we report that loss of Gpsm2 leads to decreased outgrowth and a disruption of actin dynamics in neuronal growth cones. Our results elucidate the aetiology of CMCS and highlight a new molecular role for Gpsm2/Gαi3 in the regulation of actin dynamics in epithelial and neuronal tissues.

  2. Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome (United States)

    Mauriac, Stephanie A.; Hien, Yeri E.; Bird, Jonathan E.; Carvalho, Steve Dos-Santos; Peyroutou, Ronan; Lee, Sze Chim; Moreau, Maite M.; Blanc, Jean-Michel; Geyser, Aysegul; Medina, Chantal; Thoumine, Olivier; Beer-Hammer, Sandra; Friedman, Thomas B.; Rüttiger, Lukas; Forge, Andrew; Nürnberg, Bernd; Sans, Nathalie; Montcouquiol, Mireille


    Mutations in GPSM2 cause Chudley-McCullough syndrome (CMCS), an autosomal recessive neurological disorder characterized by early-onset sensorineural deafness and brain anomalies. Here, we show that mutation of the mouse orthologue of GPSM2 affects actin-rich stereocilia elongation in auditory and vestibular hair cells, causing deafness and balance defects. The G-protein subunit Gαi3, a well-documented partner of Gpsm2, participates in the elongation process, and its absence also causes hearing deficits. We show that Gpsm2 defines an ~200 nm nanodomain at the tips of stereocilia and this localization requires the presence of Gαi3, myosin 15 and whirlin. Using single-molecule tracking, we report that loss of Gpsm2 leads to decreased outgrowth and a disruption of actin dynamics in neuronal growth cones. Our results elucidate the aetiology of CMCS and highlight a new molecular role for Gpsm2/Gαi3 in the regulation of actin dynamics in epithelial and neuronal tissues.

  3. Computational modeling of the mechanical modulation of the growth plate by sustained loading

    Directory of Open Access Journals (Sweden)

    Narváez-Tovar Carlos A


    Full Text Available Abstract This paper presents a computational model that describes the growth of the bone as a function of the proliferation and hypertrophy of chondrocytes in the growth plate. We have included the effects of the mechanical loads on the sizes of the proliferative and hypertrophic areas, the number of proliferative chondrocytes and the final size of the hypertrophic chondrocytes. The validation of the model was performed with experimental data published on other investigations about proximal tibia of rats, subjected to sustained axial stresses of 0.1 MPa, 0.0 MPa, -0.1 MPa and −0.2 MPa. Growth was simulated during 23 days, obtaining numerical errors between 2.77% and 3.73% with respect to experimental growth rates. The results obtained show that the model adequately simulates the behavior of the growth plate and the effect of mechanical loads over its cellular activity.

  4. Developing Policy Scenarios for Sustainable Urban Growth Management: A Delphi Approach

    Directory of Open Access Journals (Sweden)

    Sajida Perveen


    Full Text Available In many parts of the world, a rapid urbanization process is taking place at an unprecedented scale, and its drastic impacts on societies and the environment are evident. To combat the externalities of such rapid, and to a degree uncontrolled, development, many cities around the globe introduced various urban growth management policies. However, policy making—to provide sustainable outcomes, while generating growth opportunities—has been a daunting task for urban administrators. To ease the task, scenario-based planning methods are introduced to produce alternative visions for managing urban growth in sustainable ways by incorporating various socio-environmental issues. However, even though modelling urban growth and associated impacts based on these scenarios have emerged to strengthen and quantify the future of urban policies and related planning actions, this process has a number of glitches. Major issues include the uncertainties associated with the selection of suitable methods to generate scenarios, identify indicators to be used to assess scenarios, evaluate scenarios to prioritize for policy formulation, and assess the impacts of policy scenarios. This paper aims to address the challenge of developing suitable policy scenarios for sustainable urban growth. As for the methodological approach, the study undertakes a thorough review of the literature and current practices, and conducts a two-round Delphi survey—involving experts from public, private and academic sectors specialized in the fields of urban planning, environmental planning, social planning, transportation modelling, and economic development. The expert driven policy scenarios are validated in a local context by comparing findings against the policy options as proposed in the South East Queensland Regional Plan 2017 (Australia. The findings offer valuable guidelines for planners, modellers, and policy makers in adopting suitable methods, indicators, and policy priorities

  5. Effects of Population Growth and Climate Variability on Sustainable Groundwater in Mali, West Africa

    Directory of Open Access Journals (Sweden)

    Alexandra Lutz


    Full Text Available Groundwater is increasingly relied on as a source of potable water in developing countries, but factors such as population growth, development, and climate variability, pose potential challenges for ongoing sustainable supply. The effect of these factors on the groundwater system was considered in four scenarios using a numerical model to represent the Bani area of Mali, West Africa. By 2040, population growth, climate variability, and development as urbanization, agriculture, and industry creates scenarios in which groundwater extraction is an increasingly larger percentage of the groundwater system. Consumption from agriculture and industry increases extraction rates from less than 1 to 3.8% of mean annual precipitation, which will likely affect the groundwater system. For instance, concentrated pumping in local areas may result in water level declines. The results of this study contribute to an ongoing evaluation of sustainable groundwater resources in West Africa.

  6. Sharing Economy as a Contributor to Sustainable Growth. An EU Perspective

    Directory of Open Access Journals (Sweden)

    Florin Bonciu


    Full Text Available The paper bases its analytical approach on two assumptions: the first refers to a significant change taking place in the contemporary world economy – the phenomenon of multipolarity – and proposes a new concept, that of multi-level manifestation of multipolarity; the second has in view the need of a new model of sustainable economic growth. In the context of these two points of view, the paper analyses the sharing economy as a potential significant contributor to sustainable economic growth. The conclusion of this research is that sharing economy has a huge potential of involving millions or even billions of participants and of capitalizing the existing assets while providing spill over effects in the economy. The authors expect sharing economy to become a form of economic activity that will complement traditional forms of business while generating positive economic, social and environmental effects.

  7. Quotient normed cones

    Indian Academy of Sciences (India)

    general setting of the space CL(X, Y ) of all continuous linear mappings from a normed cone (X, p) to a normed cone (Y, q), extending several well-known results related to open continuous linear mappings between normed linear spaces. Keywords. Normed cone; extended quasi-metric; continuous linear mapping; bicom-.

  8. A Study on International Trade and Endogenous/Sustainable Growth Model considering Environment

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sang In; Kim, Tae Wan; Han, Hwa Jin; Kang, Kwang Gyu; Choi, Dae Seung [Korea Environment Institute, Seoul (Korea)


    The worldwide industrialization, which has spread from advanced industrial nations to developing nations via newly industrialized nations, and the expanded international trade have been triggering all kinds of environmental pollution, so the environmental pollution has become an environmental problem of pan-global line. The spread of modern industrial society, which is characterized by mass production and mass consumption, has been polluting an entire earth as well as a relevant area and draining usable natural resources. It has caused discord between evironmentalists - regarding environment - and developmentalists - stressing growth through industralization - to deepen. Joint Working Party on Trade and Environment 0f OECD and Committee on Trade and Environment of WTO, which was established with joint efforts of international community in order to resolve such problems, has suggested new improved methodologies to promote the protection of environment, trade liberalization, and sustainable development, besides the discussion for the establishment of reciprocal supporting relation at the same time. The concept of sustainable development, whose main objects are the protection of environment, economic growth, and social development, is recognized as an alternative program that can settle the deepened discord between developed and developing countries on the surrounding issue of the protection of environment and economic development. Because the past discussion connecting environment and trade was developed around a static analysis, it was not available to consider thoroughly the dynamic environmental effects of trade liberalization. This study started from such a critical mind has developed the theoretical analysis model on endogenous growth in order to study on the reciprocal relation among environment, trade, and growth at the first time. This report examined the reciprocal relation between environment and trade, trade and growth, and growth and environment within

  9. Graduate Programs in Green Growth and Sustainable Development: A Comparative Approach


    Fairlie Reinoso, Alan


    Since the concern about the negative impacts of the current economic modelin the scarcity of natural resources and their conservation, it comes the need toconfront them and create, from academia, some research areas that include thesenew features and development trends. In this paper, an overview of the conceptualaspects of the main proposals for the transition to sustainable development isperformed, such as the Green Growth, Bio-Commerce, Bio-Economy, amongothers. Then, it is identified and ...

  10. Role of Plant Growth Promoting Rhizobacteria in Agricultural Sustainability-A Review. (United States)

    Vejan, Pravin; Abdullah, Rosazlin; Khadiran, Tumirah; Ismail, Salmah; Nasrulhaq Boyce, Amru


    Plant growth promoting rhizobacteria (PGPR) shows an important role in the sustainable agriculture industry. The increasing demand for crop production with a significant reduction of synthetic chemical fertilizers and pesticides use is a big challenge nowadays. The use of PGPR has been proven to be an environmentally sound way of increasing crop yields by facilitating plant growth through either a direct or indirect mechanism. The mechanisms of PGPR include regulating hormonal and nutritional balance, inducing resistance against plant pathogens, and solubilizing nutrients for easy uptake by plants. In addition, PGPR show synergistic and antagonistic interactions with microorganisms within the rhizosphere and beyond in bulk soil, which indirectly boosts plant growth rate. There are many bacteria species that act as PGPR, described in the literature as successful for improving plant growth. However, there is a gap between the mode of action (mechanism) of the PGPR for plant growth and the role of the PGPR as biofertilizer-thus the importance of nano-encapsulation technology in improving the efficacy of PGPR. Hence, this review bridges the gap mentioned and summarizes the mechanism of PGPR as a biofertilizer for agricultural sustainability.

  11. Fiscal Deficit, National Saving and Sustainability of Economic Growth in Emerging Economies: A Dynamic GMM Panel Data Approach

    Directory of Open Access Journals (Sweden)

    Buscemi Antonino


    Full Text Available The neoclassical growth models argued that the movement to steady states; technology, exogenous rate of savings, population growth and technical progress stimulate higher growth levels (Solow 1956. Contrary to the neoclassical argument, endogenous growth model argues that, in the theory of endogenous growth, government play a significant role in promoting accumulation of knowledge, research and development, public investment, human capital development, law and order can generate growth both in the short and long run. Moreover, they assumed technical progress as endogenous variable for growth (Barro 1995. This study analyze the effects of fiscal deficit on sustainability of economic growth and provided new empirical evidence on the effects of fiscal deficit on saving and sustainability of economic growth based on the assumption of endogenous growth model. We estimated using the reduced form of GMM method for dynamic panels covers 1990-2009 for three emerging countries that includes China, India and South Africa.

  12. Does Renewable Energy Drive Sustainable Economic Growth? Multivariate Panel Data Evidence for EU-28 Countries

    Directory of Open Access Journals (Sweden)

    Daniel Ştefan Armeanu


    Full Text Available Energy is crucial to economic progress, but the contemporary worldwide population increase that demands greater energy generated from conventional exhaustible resources, an energy price upsurge, and environmental concerns, imperils sustainable economic growth. Nevertheless, switching to renewable energy produced from naturally replenished resources promotes energy security, likewise addressing issues such as global warming and climate change. This paper aims at exploring the influence and causal relation between renewable energy, both overall and by type, and sustainable economic growth of European Union (EU-28 countries for the period of 2003–2014. We notice that the mean share of renewable energy in the gross final energy consumption is 15%, while the mean share of renewable energy in transport fuel consumption is 3%, which are below the thresholds of 20% and 10%, respectively, as set by the EU Directive 2009/28/EC. By estimating panel data fixed-effects regression models, the results provide support for a positive influence of renewable energy overall, as well as by type, namely biomass, hydropower, geothermal energy, wind power, and solar energy on gross domestic product per capita. However, biomass energy shows the highest influence on economic growth among the rest of renewable energy types. In fact, a 1% increase of the primary production of solid biofuels increases GDP per capita by 0.16%. Besides, cointegrating regressions set on panel fully modified and dynamic ordinary least squares regressions confirm the positive influence related to the primary production of renewable energies on economic growth. A 1% increase in primary production of renewable energies increases GDP per capita by 0.05%–0.06%. However, the results of Granger causality based on panel vector error correction model indicate both in short-run and long-run a unidirectional causal relationship running from sustainable economic growth to the primary production of

  13. Efficacy and safety of sustained-release recombinant human growth hormone in Korean adults with growth hormone deficiency. (United States)

    Kim, Youngsook; Hong, Jae Won; Chung, Yoon-Sok; Kim, Sung-Woon; Cho, Yong-Wook; Kim, Jin Hwa; Kim, Byung-Joon; Lee, Eun Jig


    The administration of recombinant human growth hormone in adults with growth hormone deficiency has been known to improve metabolic impairment and quality of life. Patients, however, have to tolerate daily injections of growth hormone. The efficacy, safety, and compliance of weekly administered sustained-release recombinant human growth hormone (SR-rhGH, Declage™) supplement in patients with growth hormone deficiency were evaluated. This trial is 12-week prospective, single-arm, open-label trial. Men and women aged ≥20 years with diagnosed growth hormone deficiency (caused by pituitary tumor, trauma and other pituitary diseases) were eligible for this study. Each subject was given 2 mg (6 IU) of SR-rhGH once a week, subcutaneously for 12 weeks. Efficacy and safety at baseline and within 30 days after the 12th injection were assessed and compared. Score of Assessment of Growth Hormone Deficiency in Adults (AGHDA score) for quality of life and serum IGF-1 level. The IGF-1 level of 108.67±74.03 ng/mL was increased to 129.01±68.37 ng/mL (p=0.0111) and the AGHDA QoL score was decreased from 9.80±6.51 to 7.55±5.76 (p<0.0001) at week 12 compared with those at baseline. Adverse events included pain, swelling, erythema, and warmth sensation at the administration site, but many adverse events gradually disappeared during the investigation. Weekly administered SR-rhGH for 12 weeks effectively increased IGF-1 level and improved the quality of life in patients with GH deficiency without serious adverse events.

  14. Sustainable treatment potential of mixed algal consortia for domestic waste water: Growth and mixotrophy

    Directory of Open Access Journals (Sweden)

    Priyanka Murthy


    Full Text Available The increasing levels of generation of nutrient-rich waste water pose serious challenge. Conventional biological and chemical methods of waste water treatment have failed in meeting sustainability challenges. Naturally occurring mixed algal species reared in mixotrophic growth modes have been deployed to recover nutrients (N and P from domestic wastewater after anaerobic digestion. In this paper, we present the results pertaining to growth and mixotrophy. Pilot-scale operation shows that the cultivation methods adopted and the use of naturally selected species lead to a tendency among these species to clump at certain stages of growth that in turn float or settle rapidly making algal harvest and thereby the nutrient recovery processes energy efficient. The highest settling rate was found to be 6.37 ± 1.6 g/m2/d. Mixotrophy was seen to contribute 15 – 24 % across the various algal consortia in wastewater (polyculture.

  15. Sustainability of population growth: a case study of urban settlements in Israel. (United States)

    Portnov, B A; Pearlmutter, D


    "One of the most sensitive criteria for gauging the degree of socio-economic prosperity of an urban settlement is the ability to sustain stable rates of population growth by attracting newcomers and retaining existing population. The present paper argues that after reaching a particular size (on the average, 20-30,000 residents), urban localities in Israel tend to experience substantial changes in components of their annual population growth. Starting with this inflection point, the growth of settlements gradually becomes less dependent on natural causes (birth and death rates) than on the ability to attract newcomers and retain current residents. On the basis of this conclusion, a strategy of ¿redirecting priorities' to developing the peripheral regions of the country is suggested." excerpt

  16. Sustainability of the Chinese economic growth: a review from the institutional theory

    Directory of Open Access Journals (Sweden)

    Andrés Felipe Galindo Farfán


    Full Text Available The evolution of Chinese economic growth correlates with more or less inclusive politic and economic institutions at different points of history. At 13 century, China stood as the most technologically advanced nation in the world, where economic institutions motivates innovation and trade. In 20th century China experienced some industrialization policy by the regime, the Great Leap Forward, while in the last three decades economic growth has been pushed by an abundant workforce, implementation of economic reforms aimed at the market and promotion of domestic consumption. However, China has driven its economic activity into an authoritarian context, political and economic constraints where we could assume that sustainability of Chinese economic model with high growth rates tends to stagnate in the coming years, if political reforms are not carried out.

  17. Publication Growth in Biological Sub-Fields: Patterns, Predictability and Sustainability

    Directory of Open Access Journals (Sweden)

    Marco Pautasso


    Full Text Available Biologists are producing ever-increasing quantities of papers. The question arises of whether current rates of increase in scientific outputs are sustainable in the long term. I studied this issue using publication data from the Web of Science (1991–2010 for 18 biological sub-fields. In the majority of cases, an exponential regression explains more variation than a linear one in the number of papers published each year as a function of publication year. Exponential growth in publication numbers is clearly not sustainable. About 75% of the variation in publication growth among biological sub-fields over the two studied decades can be predicted by publication data from the first six years. Currently trendy fields such as structural biology, neuroscience and biomaterials cannot be expected to carry on growing at the current pace, because in a few decades they would produce more papers than the whole of biology combined. Synthetic and systems biology are problematic from the point of view of knowledge dissemination, because in these fields more than 80% of existing papers have been published over the last five years. The evidence presented here casts a shadow on how sustainable the recent increase in scientific publications can be in the long term.

  18. An expanded accounting framework for sustainable growth: Focus on the relationship between a focal firm and its stakeholders

    National Research Council Canada - National Science Library

    Taeyoung Yoo; Giseok Nam


    ... about relationships between a focal firm and its stakeholders. That is, we could more accurately assess the sustainability of a firm's profit and growth by considering both its financial outcomes and business relationships...

  19. Identification of microprocessor-dependent cancer cells allows screening for growth-sustaining micro-RNAs. (United States)

    Peric, D; Chvalova, K; Rousselet, G


    Micro-RNAs are deregulated in cancer cells, and some are either tumor suppressive or oncogenic. In addition, a link has been established between decreased expression of micro-RNAs and transformation, and several proteins of the RNA interference pathway have been shown to be haploinsufficient tumor suppressors. Oncogenic micro-RNAs (oncomiRs) could represent new therapeutic targets, and their identification is therefore crucial. However, structural and functional redundancy between micro-RNAs hampers approaches relying on individual micro-RNA inhibition. We reasoned that in cancer cells that depend on oncomiRs, impairing the micro-RNA pathway could lead to growth perturbation rather than increased tumorigenesis. Identifying such cells could allow functional analyses of individual micro-RNAs by complementation of the phenotypes observed upon global micro-RNA inhibition. Therefore, we developed episomal vectors coding for small hairpin RNAs targeting either Drosha or DGCR8, the two components of the microprocessor, the nuclear micro-RNA maturation complex. We identified cancer cell lines in which both vectors induced colony growth arrest. We then screened for individual micro-RNAs complementing this growth arrest, and identified miR-19a, miR-19b, miR-20a and miR-27b as major growth-sustaining micro-RNAs. However, the effect of miR-19a and miR-19b was only transient. In addition, embryonic stem cell-derived micro-RNAs with miR-20a seeds were much less efficient than miR-20a in sustaining cancer cell growth, a finding that contrasted with results obtained in stem cells. Finally, we showed that the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10, a shared target of miR-19 and miR-20, was functionally involved in the growth arrest induced by microprocessor inhibition. We conclude that our approach allowed to identify microprocessor-dependent cancer cells, which could be used to screen for growth-sustaining micro-RNAs. This complementation screen

  20. Growth-promoting effects of sustained swimming in fingerlings of gilthead sea bream (Sparus aurata L.). (United States)

    Blasco, Josefina; Moya, A; Millán-Cubillo, A; Vélez, E J; Capilla, E; Pérez-Sánchez, J; Gutiérrez, J; Fernández-Borrás, J


    Fish growth is strongly influenced by environmental and nutritional factors and changing culture conditions can help optimize it. The importance of early-life experience on the muscle phenotype later in life is well known. Here, we study the effects of 5 weeks of moderate and sustained swimming activity (5 BL s(-1)) in gilthead sea bream during early development. We analysed growth and body indexes, plasma IGF-I and GH levels, feed conversion, composition [proximate and isotopic ((15)N/(13)C)] and metabolic key enzymes (COX, CS, LDH, HOAD, HK, ALAT, ASAT) of white muscle. Moderate and continuous exercise in fingerlings of gilthead sea bream increased plasma IGF-I, whereas it reduced plasma GH. Under these conditions, growth rate improved without any modification to feed intake through an increase in muscle mass and a reduction in mesenteric fat deposits. There were no changes in the content and turnover of muscle proteins and lipid reserves. Glycogen stores were maintained, but glycogen turnover was higher in white muscle of exercised fish. A lower LDH/CS ratio demonstrated an improvement in the aerobic capacity of white muscle, while a reduction in the COX/CS ratio possibly indicated a functional adaptation of mitochondria to adjust to the tissue-specific energy demand and metabolic fuel availability in exercised fish. We discuss the synergistic effects of dietary nutrients and sustained exercise on the different mitochondrial responses.

  1. The United States after the great recession: the challenge of sustainable growth

    Energy Technology Data Exchange (ETDEWEB)

    Meltzer, Joshua [The Johns Hopkins University’s School of Advanced International Studies (United States); Steven, David (The Brookings Institution Center and the Center on International Cooperation at New York University (United States)); Langley, Claire (The Brookings Institution, Washington, DC (United States)


    The paper outlines the strengths and weaknesses of the U.S. economic growth model, assesses its’ ability to respond to the key economic, environmental and social challenges currently facing the U.S. and proposes policies that if adopted would move the U.S. onto a more sustainable growth path. The paper provides scenarios of projected future growth trajectories, as well as recommendations for specific policies in key areas: employment, infrastructure, energy and fiscal rebalancing. To reach this goal this paper focuses on four areas for action: Increasing employment, which is the most urgent priority to accelerate recovery from the Great Recession, while addressing underlying structural issues that have led to a decade of poor economic outcomes for most citizens; Investing in the future, as the key marker of whether the United States is prepared to make farsighted decisions to improve education, build new infrastructure and increase innovation; Maximizing an increased energy endowment in a way that grows the economy, while reinforcing the trend towards reducing resource demand and reducing greenhouse gas emissions; and, Fiscal rebalancing, where the United States must insulate economic recovery from the process of fiscal reform while reducing and stabilizing debt over the long term. Finally, we argue that President Obama can re-energize America’s global leadership if he builds on a platform of domestic actions that enhance the sustainability of America’s society and economy.

  2. Does Firms’ Innovation Promote Export Growth Sustainably?—Evidence from Chinese Manufacturing Firms

    Directory of Open Access Journals (Sweden)

    Liangfeng Hao


    Full Text Available Recent theoretical analysis and empirical studies have emphasized that firms’ innovation could significantly improve export growth. However, the positive effect of innovation on exports is likely to change due to unstable domestic offsetting for innovation and increasing worldwide competition for trade. This study aims to explore the dynamic link between them. We first develop a theoretical model between innovation and export growth based on the theory of heterogeneity. Export growth is measured through the dimensions of extensive margin and intensive margin so as to better investigate the effect of innovation on export performance. The propositions of mechanism analysis reveal that the effect of innovation on exports is non-linear rather than sustainable. An empirical study is followed to test the propositions by using data from a representative panel of Chinese manufacturing firms. Consistent with the theoretical predictions, the results show an inverted U-shaped relationship between innovation and extensive margin and a U-shaped relationship between innovation and intensive margin. The non-linear relations are verified by a threshold effect test. Further study shows less innovation and more firms on the left side of the relation curves. The distribution suggests irregular innovation ability among the exporters. Moreover, the role of innovation is more important for export growth and the corresponding threshold is higher in terms of high technological sectors. The contribution of this study is to introduce a comprehensive framework to investigate the dynamic effect of innovation on export growth, serving as a modest spur to induce the following studies to explore the sustainability of innovation effect.

  3. Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation. (United States)

    Baluk, Peter; Adams, Alicia; Phillips, Keeley; Feng, Jennifer; Hong, Young-Kwon; Brown, Mary B; McDonald, Donald M


    Lymphatics proliferate, become enlarged, or regress in multiple inflammatory lung diseases in humans. Lymphatic growth and remodeling is known to occur in the mouse trachea in sustained inflammation, but whether intrapulmonary lymphatics exhibit similar plasticity is unknown. We examined the time course, distribution, and dependence on vascular endothelial growth factor receptor (VEGFR)-2/VEGFR-3 signaling of lung lymphatics in sustained inflammation. Lymphatics in mouse lungs were examined under baseline conditions and 3 to 28 days after Mycoplasma pulmonis infection, using prospero heomeobox 1-enhanced green fluorescence protein and VEGFR-3 as markers. Sprouting lymphangiogenesis was evident at 7 days. Lymphatic growth was restricted to regions of bronchus-associated lymphoid tissue (BALT), where VEGF-C-producing cells were scattered in T-cell zones. Expansion of lung lymphatics after infection was reduced 68% by blocking VEGFR-2, 83% by blocking VEGFR-3, and 99% by blocking both receptors. Inhibition of VEGFR-2/VEGFR-3 did not prevent the formation of BALT. Treatment of established infection with oxytetracycline caused BALT, but not the lymphatics, to regress. We conclude that robust lymphangiogenesis occurs in mouse lungs after M. pulmonis infection through a mechanism involving signaling of both VEGFR-2 and VEGFR-3. Expansion of the lymphatic network is restricted to regions of BALT, but lymphatics do not regress when BALT regresses after antibiotic treatment. The lung lymphatic network can thus expand in sustained inflammation, but the expansion is not as reversible as the accompanying inflammation. Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  4. The importance of training for sustainable growth: Example of Six Sigma implementation

    Directory of Open Access Journals (Sweden)

    Nastasić Aleksandra P.


    Full Text Available Improvement of the business environment, education and training are the basis for sustainable growth. Implementation of Six Sigma (6σ concept and appropriate techniques and tools for quality management contribute to the efficiency and effectiveness of the business as a whole, in a manner that organization achieves and maintains competitive advantage by reducing process variability, costs of scraps, price and need for control, shortening production cycle and increasing product quality, customer satisfaction and profit. Successful implementation of Six Sigma (6σ concept requires involvement of all employees and appropriate level of training.

  5. How can maritime spatial planning contribute to sustainable Blue Growth in the Baltic Sea?


    Tarvainen, Hanna; Tolvanen, Harri; Repka, Sari


    The sea and the coasts are drivers of Europe’s economy as many of the economic activities as well as large part of trade depend on the sea. At the European level there is strong political pressure to enhance the growth of maritime economy sectors. The European Union has developed the Integrated Maritime Policy to support the sustainable development of the seas and oceans. The aim is to reach a good environmental status of European seas by 2020. The value of this study is to provi...

  6. Cones in Supersonic Flow (United States)

    Hantzsche, W.; Wendt, H.


    In the case of cones in axially symmetric flow of supersonic velocity, adiabatic compression takes place between shock wave and surface of the cone. Interpolation curves betwen shock polars and the surface are therefore necessary for the complete understanding of this type of flow. They are given in the present report by graphical-numerical integration of the differential equation for all cone angles and airspeeds.

  7. Orientation-specific responses to sustained uniaxial stretching in focal adhesion growth and turnover (United States)

    Chen, Yun; Pasapera, Ana M.; Koretsky, Alan P.; Waterman, Clare M.


    Cells are mechanosensitive to extracellular matrix (ECM) deformation, which can be caused by muscle contraction or changes in hydrostatic pressure. Focal adhesions (FAs) mediate the linkage between the cell and the ECM and initiate mechanically stimulated signaling events. We developed a stretching apparatus in which cells grown on fibronectin-coated elastic substrates can be stretched and imaged live to study how FAs dynamically respond to ECM deformation. Human bone osteosarcoma epithelial cell line U2OS was transfected with GFP-paxillin as an FA marker and subjected to sustained uniaxial stretching. Two responses at different timescales were observed: rapid FA growth within seconds after stretching, and delayed FA disassembly and loss of cell polarity that occurred over tens of minutes. Rapid FA growth occurred in all cells; however, delayed responses to stretch occurred in an orientation-specific manner, specifically in cells with their long axes perpendicular to the stretching direction, but not in cells with their long axes parallel to stretch. Pharmacological treatments demonstrated that FA kinase (FAK) promotes but Src inhibits rapid FA growth, whereas FAK, Src, and calpain 2 all contribute to delayed FA disassembly and loss of polarity in cells perpendicular to stretching. Immunostaining for phospho-FAK after stretching revealed that FAK activation was maximal at 5 s after stretching, specifically in FAs oriented perpendicular to stretch. We hypothesize that orientation-specific activation of strain/stress-sensitive proteins in FAs upstream to FAK and Src promote orientation-specific responses in FA growth and disassembly that mediate polarity rearrangement in response to sustained stretch. PMID:23754369

  8. Furthering knowledge of seaweed growth and development to facilitate sustainable aquaculture. (United States)

    Charrier, Bénédicte; Abreu, Maria Helena; Araujo, Rita; Bruhn, Annette; Coates, Juliet C; De Clerck, Olivier; Katsaros, Christos; Robaina, Rafael R; Wichard, Thomas


    Macroalgae (seaweeds) are the subject of increasing interest for their potential as a source of valuable, sustainable biomass in the food, feed, chemical and pharmaceutical industries. Compared with microalgae, the pace of knowledge acquisition in seaweeds is slower despite the availability of whole-genome sequences and model organisms for the major seaweed groups. This is partly a consequence of specific hurdles related to the large size of these organisms and their slow growth. As a result, this basic scientific field is falling behind, despite the societal and economic importance of these organisms. Here, we argue that sustainable management of seaweed aquaculture requires fundamental understanding of the underlying biological mechanisms controlling macroalgal life cycles - from the production of germ cells to the growth and fertility of the adult organisms - using diverse approaches requiring a broad range of technological tools. This Viewpoint highlights several examples of basic research on macroalgal developmental biology that could enable the step-changes which are required to adequately meet the demands of the aquaculture sector. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  9. Four Sustainability Goals in a Swedish Low-Growth/Degrowth Context

    Directory of Open Access Journals (Sweden)

    Eléonore Fauré


    Full Text Available Continual environmental degradation and an unfair distribution of environmental burdens and benefits are two great challenges for humanity. Economic growth is often taken for granted when planning for the future. However, it is often argued that maintaining economic growth conflicts with keeping human activities adjusted to ecological boundaries and finite resources, at least for the more-developed countries. With this paper, we present sustainability goals for building and planning in Sweden to be achieved by 2050 in a context of limited or even negative economic growth. These goals should ensure that all groups in society have sufficient resources and a good life within planetary boundaries. We select four goals in a participatory process: two environmental goals related to climate change and land use and two social goals related to welfare and participation. Our results show that achieving the environmental goals will require significant reductions of Sweden’s greenhouse gas (GHG emissions and land use compared to today’s levels. Regarding the social goals, these are, in many aspects, reasonably well fulfilled in Sweden today, although disparities remain between groups of citizens. The main challenge, however, is to ensure that these goals are fulfilled even within environmental limits and if economic growth should halt.

  10. The Impact of the Quality of Coal Mine Stockpile Soils on Sustainable Vegetation Growth and Productivity

    Directory of Open Access Journals (Sweden)

    Nicky M Mushia


    Full Text Available Stockpiled soils are excavated from the ground during mining activities, and piled on the surface of the soil for rehabilitation purposes. These soils are often characterized by low organic matter (SOM content, low fertility, and poor physical, chemical, and biological properties, limiting their capability for sustainable vegetation growth. The aim of the study was to evaluate the impact of stockpile soils of differing depth and quality on vegetation growth and productivity. Soils were collected at three different depths (surface, mid, and deep as well as mixed (equal proportion of surface, mid and deep from two stockpiles (named Stockpile 1: aged 10 and Stockpile 2: 20 years at the coal mine near Witbank in the Mpumalanga province of South Africa. Soils were amended with different organic and inorganic fertilizer. A 2 × 4 × 5 factorial experiment in a completely randomized blocked design with four replications was established under greenhouse conditions. A grass species (Digiteria eriantha was planted in the pots with unamended and amended soils under greenhouse conditions at 26–28 °C during the day and 16.5–18.5 °C at night. Mean values of plant height, plant cover, total fresh biomass (roots, stems and leaves, and total dry biomass were found to be higher in Stockpile 1 than in Stockpile 2 soils. Plants grown on soils with no amendments had lower mean values for major plant parameters studied. Soil amended with poultry manure and lime was found to have higher growth rate compared with soils with other soil amendments. Mixed soils had better vegetation growth than soil from other depths. Stockpiled soils in the study area cannot support vegetation growth without being amended, as evidenced by low grass growth and productivity in this study.

  11. S-cone psychophysics. (United States)

    Smithson, Hannah E


    We review the features of the S-cone system that appeal to the psychophysicist and summarize the celebrated characteristics of S-cone mediated vision. Two factors are emphasized: First, the fine stimulus control that is required to isolate putative visual mechanisms and second, the relationship between physiological data and psychophysical approaches. We review convergent findings from physiology and psychophysics with respect to asymmetries in the retinal wiring of S-ON and S-OFF visual pathways, and the associated treatment of increments and decrements in the S-cone system. Beyond the retina, we consider the lack of S-cone projections to superior colliculus and the use of S-cone stimuli in experimental psychology, for example to address questions about the mechanisms of visually driven attention. Careful selection of stimulus parameters enables psychophysicists to produce entirely reversible, temporary, "lesions," and to assess behavior in the absence of specific neural subsystems.

  12. Forced sustained swimming exercise at optimal speed enhances growth of juvenile yellowtail kingfish (Seriola lalandi). (United States)

    Palstra, Arjan P; Mes, Daan; Kusters, Kasper; Roques, Jonathan A C; Flik, Gert; Kloet, Kees; Blonk, Robbert J W


    Swimming exercise at optimal speed may optimize growth performance of yellowtail kingfish in a recirculating aquaculture system. Therefore, optimal swimming speeds (U opt in m s(-1) or body lengths s(-1), BL s(-1)) were assessed and then applied to determine the effects of long-term forced and sustained swimming at U opt on growth performance of juvenile yellowtail kingfish. U opt was quantified in Blazka-type swim-tunnels for 145, 206, and 311 mm juveniles resulting in values of: (1) 0.70 m s(-1) or 4.83 BL s(-1), (2) 0.82 m s(-1) or 3.25 BL s(-1), and (3) 0.85 m s(-1) or 2.73 BL s(-1). Combined with literature data from larger fish, a relation of U opt (BL s(-1)) = 234.07(BL)(-0.779) (R (2) = 0.9909) was established for this species. Yellowtail kingfish, either forced to perform sustained swimming exercise at an optimal speed of 2.46 BL s(-1) ("swimmers") or allowed to perform spontaneous activity at low water flow ("resters") in a newly designed 3600 L oval flume (with flow created by an impeller driven by an electric motor), were then compared. At the start of the experiment, ten fish were sampled representing the initial condition. After 18 days, swimmers (n = 23) showed a 92% greater increase in BL and 46% greater increase in BW as compared to resters (n = 23). As both groups were fed equal rations, feed conversion ratio (FCR) for swimmers was 1.21 vs. 1.74 for resters. Doppler ultrasound imaging showed a statistically significant higher blood flow (31%) in the ventral aorta of swimmers vs. resters (44 ± 3 vs. 34 ± 3 mL min(-1), respectively, under anesthesia). Thus, growth performance can be rapidly improved by optimal swimming, without larger feed investments.

  13. Sustained delivery of vincristine inside an orthotopic mouse sarcoma model decreases tumor growth. (United States)

    Harris, Jamie C; Coburn, Jeannine M; Kajdacsy-Balla, Andre; Kaplan, David L; Chiu, Bill


    Sarcoma accounts for 20% of solid tumors in children. Surgery has significant morbidity. We hypothesized that delivering chemotherapy directly into tumors through sustained release silk systems could slow tumor growth. Human Ewing sarcoma cells A673 were cultured with vincristine and doxorubicin to determine half maximal inhibitory concentration (IC50). Cells were injected into mouse hind leg to create orthotopic tumors. Tumor volumes were measured using ultrasound. When volume reached >250mm(3,) interventions included: implantation of drug-free silk foam (Control-F), doxorubicin 400μg foam (Dox400-F), vincristine 50μg foam (Vin50-F), drug-free silk gel (Control-G), vincristine 50μg gel (Vin50-G), or single dose intravenous vincristine 50μg (Vin50-IV). End-point was volume>1000mm(3). Kaplan Meier and ANOVA were used. IC50 for vincristine and doxorubicin was 0.5ng/mL and 200ng/mL, respectively. There was no difference between Dox400-F [6±1days to end point (DTEP)] and Control-F (5±1.3 DTEP). Vin50-F (12.4±3.5 DTEP) had slower growth compared to Control-F (pinside the sarcoma tumor with silk gel decreased tumor growth. Applying this intratumoral treatment strategy may potentially decrease the extent of surgical excision. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Transcription controls growth, cell kinetics and cholesterol supply to sustain ACTH responses. (United States)

    Menzies, Robert I; Zhao, Xin; Mullins, Linda J; Mullins, John J; Cairns, Carolynn; Wrobel, Nicola; Dunbar, Donald R; Bailey, Matthew A; Kenyon, Christopher J


    Chronic ACTH exposure is associated with adrenal hypertrophy and steroidogenesis. The underlying molecular processes in mice have been analysed by microarray, histological and immunohistochemical techniques. Synacthen infused for 2 weeks markedly increased adrenal mass and plasma corticosterone levels. Microarray analysis found greater than 2-fold changes in expression of 928 genes (P change in cell proliferation. Growth arrest genes, Cdkn1a and Cdkn1c, which are known to be active in hypertrophied cells, were increased >4-fold and cross-sectional area of fasciculata cells was 2-fold greater. In contrast, genes associated with apoptosis (eg Casp12, Clu,) were downregulated and apoptotic cells (Tunel staining) were fewer (P sustained by genes controlling cholesterol supply and adrenal mass. ACTH effects on adrenal morphology and genes controlling cell hypertrophy, proliferation and apoptosis suggest the involvement of different cell types and separate molecular pathways. © 2017 The authors.

  15. Synthesis of multilayered alginate microcapsules for the sustained release of fibroblast growth factor-1 (United States)

    Khanna, Omaditya; Moya, Monica L; Opara, Emmanuel C; Brey, Eric M


    Alginate microcapsules coated with a permselective poly-L-ornithine (PLO) membrane have been investigated for the encapsulation and transplantation of islets as a treatment for type 1 diabetes. The therapeutic potential of this approach could be improved through local stimulation of microvascular networks in order to meet mass transport demands of the encapsulated cells. Fibroblast growth factor-1 (FGF-1) is a potent angiogenic factor with optimal effect occurring when it is delivered in a sustained manner. In this paper, a technique is described for the generation of multilayered alginate microcapsules with an outer alginate layer that can be used for the delivery of FGF-1. The influence of alginate concentration and composition (high mannuronic acid (M) or guluronic acid (G) content) on outer layer size and stability, protein encapsulation efficiency, and release kinetics was investigated. The technique results in a stable outer layer of alginate with a mean thickness between 113–164 µm, increasing with alginate concentration and G-content. The outer layer was able to encapsulate and release FGF-1 for up to thirty days, with 1.25% of high G alginate displaying the most sustained release. The released FGF-1 retained its biologic activity in the presence of heparin, and the addition of the outer layer did not alter the permselectivity of the PLO coat. This technique could be used to generate encapsulation systems that deliver proteins to stimulate local neovascularization around encapsulated islets. PMID:20725969

  16. Calcium-Alginate Hydrogel-Encapsulated Fibroblasts Provide Sustained Release of Vascular Endothelial Growth Factor (United States)

    Hunt, Nicola C.; Shelton, Richard M.; Henderson, Deborah J.


    Vascularization of engineered or damaged tissues is essential to maintain cell viability and proper tissue function. Revascularization of the left ventricle (LV) of the heart after myocardial infarction is particularly important, since hypoxia can give rise to chronic heart failure due to inappropriate remodeling of the LV after death of cardiomyocytes (CMs). Fibroblasts can express vascular endothelial growth factor (VEGF), which plays a major role in angiogenesis and also acts as a chemoattractant and survival factor for CMs and cardiac progenitors. In this in vitro model study, mouse NIH 3T3 fibroblasts encapsulated in 2% w/v Ca-alginate were shown to remain viable for 150 days. Semiquantitative reverse transcription–polymerase chain reaction and immunohistochemistry demonstrated that over 21 days of encapsulation, fibroblasts continued to express VEGF, while enzyme-linked immunosorbent assay showed that there was sustained release of VEGF from the Ca-alginate during this period. The scaffold degraded gradually over the 21 days, without reduction in volume. Cells released from the Ca-alginate at 7 and 21 days as a result of scaffold degradation were shown to retain viability, to adhere to fibronectin in a normal manner, and continue to express VEGF, demonstrating their potential to further contribute to maintenance of cardiac function after scaffold degradation. This model in vitro study therefore demonstrates that fibroblasts encapsulated in Ca-alginate provide sustained release of VEGF. PMID:23082964

  17. Open Innovation Projects in SMEs as an Engine for Sustainable Growth

    Directory of Open Access Journals (Sweden)

    Byungun Yoon


    Full Text Available Most innovation activities that are inevitable for sustainable growth are coordinated via research and development (R&D projects, which can differ widely in terms of both project and open innovation characteristics, even when conducted within the same firm. Therefore, it is important to consider the peculiarities of R&D projects when evaluating the performance of open innovation strategies, as well as to explore how the benefits and costs of open innovation are shaped by cross-level interactions. This study identifies the differences between successful and unsuccessful open innovation projects, in both firm-level and project-level terms. We focus on small and medium enterprises (SMEs, which usually lack the full set of internal resources and competences required to effectively develop, produce, and commercialize their innovations, and thus must adopt open innovation approaches more actively for sustainability. Adopting an empirical approach, we conducted a survey of 517 Korean SMEs and analyzed 241 successful and unsuccessful open innovation projects in depth. By combining measurements at the firm and project levels, this study provides new insight into the intra-organizational challenges of implementing open innovation projects, which are not only helpful to strategic decision-makers in SMEs, but also to those who make policies for them.

  18. Revitalization of plant growth promoting rhizobacteria for sustainable development in agriculture. (United States)

    Gouda, Sushanto; Kerry, Rout George; Das, Gitishree; Paramithiotis, Spiros; Shin, Han-Seung; Patra, Jayanta Kumar


    The progression of life in all forms is not only dependent on agricultural and food security but also on the soil characteristics. The dynamic nature of soil is a direct manifestation of soil microbes, bio-mineralization, and synergistic co-evolution with plants. With the increase in world's population the demand for agriculture yield has increased tremendously and thereby leading to large scale production of chemical fertilizers. Since the use of fertilizers and pesticides in the agricultural fields have caused degradation of soil quality and fertility, thus the expansion of agricultural land with fertile soil is near impossible, hence researchers and scientists have sifted their attention for a safer and productive means of agricultural practices. Plant growth promoting rhizobacteria (PGPR) has been functioning as a co-evolution between plants and microbes showing antagonistic and synergistic interactions with microorganisms and the soil. Microbial revitalization using plant growth promoters had been achieved through direct and indirect approaches like bio-fertilization, invigorating root growth, rhizoremediation, disease resistance etc. Although, there are a wide variety of PGPR and its allies, their role and usages for sustainable agriculture remains controversial and restricted. There is also variability in the performance of PGPR that may be due to various environmental factors that might affect their growth and proliferation in the plants. These gaps and limitations can be addressed through use of modern approaches and techniques such as nano-encapsulation and micro-encapsulation along with exploring multidisciplinary research that combines applications in biotechnology, nanotechnology, agro biotechnology, chemical engineering and material science and bringing together different ecological and functional biological approaches to provide new formulations and opportunities with immense potential. Copyright © 2017 Elsevier GmbH. All rights reserved.

  19. Meeting the Sustainable Development Goals leads to lower world population growth. (United States)

    Abel, Guy J; Barakat, Bilal; Kc, Samir; Lutz, Wolfgang


    Here we show the extent to which the expected world population growth could be lowered by successfully implementing the recently agreed-upon Sustainable Development Goals (SDGs). The SDGs include specific quantitative targets on mortality, reproductive health, and education for all girls by 2030, measures that will directly and indirectly affect future demographic trends. Based on a multidimensional model of population dynamics that stratifies national populations by age, sex, and level of education with educational fertility and mortality differentials, we translate these goals into SDG population scenarios, resulting in population sizes between 8.2 and 8.7 billion in 2100. Because these results lie outside the 95% prediction range given by the 2015 United Nations probabilistic population projections, we complement the study with sensitivity analyses of these projections that suggest that those prediction intervals are too narrow because of uncertainty in baseline data, conservative assumptions on correlations, and the possibility of new policies influencing these trends. Although the analysis presented here rests on several assumptions about the implementation of the SDGs and the persistence of educational, fertility, and mortality differentials, it quantitatively illustrates the view that demography is not destiny and that policies can make a decisive difference. In particular, advances in female education and reproductive health can contribute greatly to reducing world population growth.

  20. Sustaining intrinsic growth capacity of adult neurons promotes spinal cord regeneration (United States)

    Neumann, Simona; Skinner, Kate; Basbaum, Allan I.


    The peripheral axonal branch of primary sensory neurons readily regenerates after peripheral nerve injury, but the central branch, which courses in the dorsal columns of the spinal cord, does not. However, if a peripheral nerve is transected before a spinal cord injury, sensory neurons that course in the dorsal columns will regenerate, presumably because their intrinsic growth capacity is enhanced by the priming peripheral nerve lesion. As the effective priming lesion is made before the spinal cord injury it would clearly have no clinical utility, and unfortunately, a priming lesion made after a spinal cord injury results in an abortive regenerative response. Here, we show that two priming lesions, one made at the time of a spinal cord injury and a second 1 week after a spinal cord injury, in fact, promote dramatic regeneration, within and beyond the lesion. The first lesion, we hypothesize, enhances intrinsic growth capacity, and the second one sustains it, providing a paradigm for promoting CNS regeneration after injury. primary afferents | dorsal columns | neurite outgrowth | sprouting | priming

  1. Urban Growth Dynamics in Perth, Western Australia: Using Applied Remote Sensing for Sustainable Future Planning

    Directory of Open Access Journals (Sweden)

    Andrew MacLachlan


    Full Text Available Earth observation data can provide valuable assessments for monitoring the spatial extent of (unsustainable urban growth of the world’s cities to better inform planning policy in reducing associated economic, social and environmental costs. Western Australia has witnessed rapid economic expansion since the turn of the century founded upon extensive natural resource extraction. Thus, Perth, the state capital of Western Australia, has encountered significant population and urban growth in response to the booming state economy. However, the recent economic slowdown resulted in the largest decrease in natural resource values that Western Australia has ever experienced. Here, we present multi-temporal urban expansion statistics from 1990 to 2015 for Perth, derived from Landsat imagery. Current urban estimates used for future development plans and progress monitoring of infill and density targets are based upon aggregated census data and metrics unrepresentative of actual land cover change, underestimating overall urban area. Earth observation provides a temporally consistent methodology, identifying areal urban area at higher spatial and temporal resolution than current estimates. Our results indicate that the spatial extent of the Perth Metropolitan Region has increased 45% between 1990 and 2015, over 320 km2. We highlight the applicability of earth observation data in accurately quantifying urban area for sustainable targeted planning practices.

  2. How to stop the snowball growth? A way for sustaining public debt over generations

    Directory of Open Access Journals (Sweden)

    Catrina Ion-Lucian


    Full Text Available Why public debts are growing so fast in most developing countries, like a dangerous snowball which is growing and growing and no one can stop it? It is only a negative relation between high debt and real growth of economy? How can we definitively remove the Ricardian anxiety which called debt a “terrible scourge”? These are only few questions asked in the last century in relation with debt “overhang” not only by scholars, but by governments as well. This paper aims to answer to other questions like: Why debt’s rate grows faster than GDP? Why governments borrow? For current spending or for public investments? Who should benefits current loans? Who should pay for them and when? How should be the taxation along the economic cycle: neutral or countercyclical? Need we a model to sustain the public debt over generations, or it is good enough to maintain a good ration between real GDP growth and debt and that’s it?

  3. Predicting the Performance and Survival of Islamic Banks in Malaysia to Achieve Growth Sustainability

    Directory of Open Access Journals (Sweden)

    Mazuin Sapuan Noraina


    Full Text Available In Malaysia, the growth of the Islamic financial industry has increased tremendously in line with the Government’s ambition to make Malaysia as an international hub for Islamic finance since 2010. With the increasing number of foreign players in this industry plus with the increasing demand from domestic and foreign customers would further enhance the possibility for Malaysia to achieve this ambition. Currently, according to the Economic Transformation Programme, 2012 Malaysia is the world’s third largest market for Shariah assets that cover Islamic banks, Takaful, and sukuk. Malaysia as one of the main contributors to the global Islamic financial assets with Islamic assets in Malaysia grew by 23.8% in 2011 from RM350.8bil to RM434.6bil. The issues of predicting the performance and the survival of Islamic Banks in Malaysia become amongst crucial issues in academic research. By employing multi – layer perceptron neural network and pooled regression, we found that total assets/ size of the Islamic banks (GROWTH have high weightage and significantly influence in predicting the performance and the survival of Islamic banks in Malaysia. With the increasing number of Islamic banking institutions in Malaysia, this study can give insight on the sustainability of the Islamic banking system in Malaysia for the benefit of the investors, shareholder and depositors.

  4. Energy efficiency, human behavior, and economic growth: Challenges to cutting energy demand to sustainable levels (United States)

    Santarius, Tilman


    Increasing energy efficiency in households, transportation, industries, and services is an important strategy to reduce energy service demand to levels that allow the steep reduction of greenhouse gases, and a full fledged switch of energy systems to a renewable basis. Yet, technological efficiency improvements may generate so-called rebound effects, which may `eat up' parts of the technical savings potential. This article provides a comprehensive review of existing research on these effects, raises critiques, and points out open questions. It introduces micro-economic rebound effect and suggests extending consumer-side analysis to incorporate potential `psychological rebound effects.' It then discusses meso-economic rebound effects, i.e. producer-side and market-level rebounds, which so far have achieved little attention in the literature. Finally, the article critically reviews evidence for macro-economic rebound effects as energy efficiency-induced economic growth impacts. For all three categories, the article summarizes assessments of their potential quantitative scope, while pointing out remaining methodological weaknesses and open questions. As a rough "rule of thumb", in the long term and on gross average, only half the technical savings potential of across-the-board efficiency improvements may actually be achieved in the real world. Policies that aim at cutting energy service demand to sustainable levels are well advised to take due note of detrimental behavioral and economic growth impacts, and should foster policies and measures that can contain them.

  5. Forced sustained swimming exercise at optimal speed enhances growth of juvenile yellowtail kingfish (Seriola lalandi

    Directory of Open Access Journals (Sweden)

    Arjan P. Palstra


    Full Text Available Swimming exercise at optimal speed may optimize growth performance of yellowtail kingfish in a recirculating aquaculture system. Therefore, optimal swimming speeds (Uopt in m s-1 or body lengths s-1, BL s-1 were assessed and then applied to determine the effects of long-term forced and sustained swimming at Uopt on growth performance of juvenile yellowtail kingfish. Uopt was quantified in Blazka-type swim-tunnels for 145 mm, 206 mm and 311 mm juveniles resulting in values of: 1 0.70 m s-1 or 4.83 BL s-1, 2 0.82 m s-1 or 3.25 BL s-1 and 3 0.85 m s-1 or 2.73 BL s-1. Combined with literature data from larger fish, a relation of Uopt (BL s-1 = 234.07(BL-0.779 (R2= 0.9909 was established for this species. Yellowtail kingfish, either forced to perform sustained swimming exercise at an optimal speed of 2.46 BL s-1 (‘swimmers’ or allowed to perform spontaneous activity at low water flow (‘resters’ in a newly designed 3,600 L oval flume (with flow created by an impeller driven by an electric motor, were then compared. At the start of the experiment, ten fish were sampled representing the initial condition. After 18 days, swimmers (n= 23 showed a 92% greater increase in BL and 46% greater increase in BW as compared to resters (n= 23. As both groups were fed equal rations, feed conversion ratio (FCR for swimmers was 1.21 vs. 1.74 for resters. Doppler ultrasound imaging showed a statistically significant higher blood flow (31% in the ventral aorta of swimmers vs. resters (44 ± 3 mL min-1 vs. 34 ± 3 mL min-1, respectively, under anesthesia. Thus growth performance can be rapidly improved by optimal swimming, without larger feed investments.

  6. Sustainable Growth in Urbanised Delta Areas : The Opportunities of a Geographical Approach to the Pearl River Delta

    NARCIS (Netherlands)

    Van Rens, G.; Nillisen, A.L.; Schamhart, C.; Lugt, N.


    The attractions of delta areas have boomed economies and founded major cities, but the threats of the adjacent water have persisted and natural resources have declined. The objective to facilitate sustainable urban growth in delta areas can only be met by a simultaneous approach of all the

  7. Towards the Development of an Integrated Sustainability and Resilience Benefits Assessment Framework of Urban Green Growth Interventions

    Directory of Open Access Journals (Sweden)

    Stelios Grafakos


    Full Text Available Considering the current emerging demographic, urbanization and climatic trends, integrating sustainability and resilience principles into urban development becomes a key priority for decision-makers worldwide. Local and national governments, project developers and other urban stakeholders dealing with the complexities of urban development need projects with clear structure and outcomes in order to inform decision-making and ensure sources of financing. The need for developing an integrated assessment methodology that would capture and quantify multiple urban sustainability and resilience benefits of projects in one common framework and eventually lead to verifiable sustainability and resilience outcomes is immense and challenging at the same time. The main objective of this paper is to present the development of a methodological approach that aims to integrate sustainability and resilience benefits, derived from the implementation of green growth urban projects, into a unified framework of criteria addressing environmental, social, economic and institutional perspectives. The proposed sustainability and resilience benefits assessment (SRBA methodology is a combination of top down and bottom up approaches, including GIS-based scenario building. The different types of sustainability and resilience benefits of urban green growth projects are also identified at different levels (i.e., individual, neighborhood, city and global. Moreover, the proposed methodology creates scenarios that can be illustrated by a map-based approach to enable a better illustration and visualization of benefits. It demonstrates how a map-based approach can assess not only the extent of sustainability and resilience benefits accrued (how much is benefitted, but also their spatial distribution (who is benefitted. The main methodological challenges and issues on developing an integrated sustainability and resilience benefits assessment are identified and discussed.

  8. Sustained-release genistein from nanostructured lipid carrier suppresses human lens epithelial cell growth

    Directory of Open Access Journals (Sweden)

    Jin-Lu Liu


    Full Text Available AIM: To design and investigate the efficacy of a modified nanostructured lipid carrier loaded with genistein (Gen-NLC to inhibit human lens epithelial cells (HLECs proliferation. METHODS: Gen-NLC was made by melt emulsification method. The morphology, particle size (PS, zeta potentials (ZP, encapsulation efficiency (EE and in vitro release were characterized. The inhibition effect of nanostructured lipid carrier (NLC, genistein (Gen and Gen-NLC on HLECs proliferation was evaluated by cell counting kit-8 (CCK-8 assay, gene and protein expression of the proliferation marker Ki67 were evaluated with real-time quantitative polymerase chain reaction (RT-qPCR and immunofluorescence analyses. RESULTS: The mean PS of Gen-NLC was 80.12±1.55 nm with a mean polydispersity index of 0.11±0.02. The mean ZP was -7.14±0.38 mV and the EE of Gen in the nanoparticles was 92.3%±0.73%. Transmission electron microscopy showed that Gen-NLC displayed spherical-shaped particles covered by an outer-layer structure. In vitro release experiments demonstrated a prolonged drug release for 72h. The CCK-8 assay results showed the NLC had no inhibitory effect on HLECs and Gen-NLC displayed a much more prominent inhibitory effect on cellular growth compared to Gen of the same concentration. The mRNA and protein expression of Ki67 in LECs decreased significantly in Gen-NLC group. CONCLUSION: Sustained drug release by Gen-NLCs may impede HLEC growth.


    Directory of Open Access Journals (Sweden)



    Full Text Available The educational system will need to direct its actions and programs towards the identification of the current and future values of the labour market, starting from the existing and potential labour resources, anticipating first and foremost the adjusting of the economy to fast-developing fields and domains, put forward by the State via the Fast-developing Field Strategies or even via the Fast-developing National Strategy. It will accordingly generate a binder between the demands of the labour market as a response to the developing necessities of the economy, and the training/specialization of the labour force as offered by the national syllabus. By these means the educational system would create a labour force compatible with the labour market, which is both a premiss for the increasing level of employment and for the sustainable economic growth. Our task is therefore to provide a concept of education related to technological progress, based on the model of Nelson and Phelps, and a suggestion for investments and education policies.

  10. Typology and Success Factors of Collaboration for Sustainable Growth in the IT Service Industry

    Directory of Open Access Journals (Sweden)

    Changbyung Yoon


    Full Text Available Recently, innovative changes in information technology (IT trends, such as cloud computing and deep learning, have led IT companies to focus on collaboration for sustainable growth. This paper investigates collaboration strategies and success factors for IT service companies via a survey-based empirical study of Korean leading IT firms. Four types of collaboration were identified by considering the types of customer relationship and the target market: offshore, joint venture, collaboration with small and medium-sized enterprises (SMEs, and partnership with major local firms. Then, based on a Plan-Do-See management activity process, this paper considers success factors in the planning process and collaboration process, and analyzes an impact of these factors on collaboration performance such as financial performance, process innovation, improving competitiveness, and technology acquisition. As a result, the success factors differ according to the types of performance measures as well as the collaboration types. In particular, the characteristics of partners positively influence competitiveness in captive and global markets, while they improve process innovation in open and domestic markets. This study attempts to provide insight for companies in the IT service industry about how collaboration activities could enhance performance, depending on the alliance types.

  11. A Theoretical Essay on Sustainability and Environmentally Balanced Output Growth: Natural Capital, Constrained Depletion of Resources and Pollution Generation

    Directory of Open Access Journals (Sweden)

    Augusto Marcos Carvalho de Sena


    Full Text Available The fact that today’s activities are imposing a heavy burden on the earth's capacity has led to an increasing interest in environmental issues. It is emphasized that rapid production growth has exhausted natural resources and polluted the environment. The objective of this essay is to offer a clear definition of natural capital, connect it to a qualitative concept of sustainability and, supported by two analytical models and a set of studies on related environmental literature, to show that sustainability can be attained via imposition of controls over production processes that use depletable natural resources and generate pollution. The methodology used contemplates an integrative approach combining a qualitative (seeking definitions-analytical (appraising models apparatus to reach a new conceptual perspective to conceive sustainability. As the main essay’s contribution, it is showed that sustainability can be reached if compensation is allowed for, i.e., stocks of renewable being augmented as production depletes the stocks of nonrenewable natural resources. Moreover, that result is possible even considering nondecreasing output production, an important finding to contrast with the current environmentally based output growth literature, which asserts that slowing down output production is the only way to obtain sustainability.

  12. Divergent Developmental Trajectories and Strategic Coupling in the Pearl River Delta: Where Is a Sustainable Way of Regional Economic Growth?

    Directory of Open Access Journals (Sweden)

    Yi Liu


    Full Text Available This paper interprets regional economic sustainability in the context of the globalization of late-coming regions. Drawing upon the concept of strategic coupling from economic geography, this paper proposes two types of strategic coupling, captive and proactive coupling, for better understanding regional sustainability and resilience through the experiences of the Pearl River Delta in China. It finds that sub-regional economies under captive coupling become highly dependent on exogenous growth and are vulnerable to external shocks. This trajectory looks less sustainable according to the general understanding, but it interestingly shows better resilience during and after the 2008 global financial crisis. In contrast, the ones under proactive coupling are less volatile, but growing much slower and are less resilient. By reporting these regional economic dynamics, this paper argues that sustainability in late-coming regions cannot be explained by either intra-regional forces or the means of global integration alone. In contrast, it has to be explained by the combination of both; the alleged strategic coupling in which economic growth and learning happens. This paper thus calls for greater attention to strategic coupling, the trade-off of globalization and resilience for understanding regional sustainability, rather than purely focusing on resource utilization and ecological balance.

  13. Sustainable Growth and Ethics: A Study of Business Ethics in Vietnam between Business Students and Working Adults

    Directory of Open Access Journals (Sweden)

    Lam D. Nguyen


    Full Text Available Sustainable growth is not only the ultimate goal of business corporations but also the primary target of local governments as well as regional and global economies. One of the cornerstones of sustainable growth is ethics. An ethical organizational culture provides support to achieve sustain- able growth. Ethical leaders and employees have great potential for positive influence on decisions and behaviors that lead to sustainability. Ethical behavior, therefore, is expected of everyone in the modern workplace. As a result, companies devote many resources and training programs to make sure their employees live according to the high ethical standards. This study provides an analysis of Vietnamese business students’ level of ethical maturity based on gender, education, work ex- perience, and ethics training. The results of data from 260 business students compared with 704 working adults in Vietnam demonstrate that students have a significantly higher level of ethical maturity. Furthermore, gender and work experience are significant factors in ethical maturity. While more educated respondents and those who had completed an ethics course did have a higher level of ethical maturity, the results were not statistically significant. Analysis of the results along with suggestions and implications are provided.

  14. different outer cone angle

    Directory of Open Access Journals (Sweden)

    Smyk Emil


    Full Text Available One of the method of flow separation control is application of axisymmetric valve. It is composed of nozzle with core. Normally the main flow is attached to inner cone and flow by preferential collector to primary flow pipe. If through control nozzle starts flow jet (control jet the main flow is switched to annular secondary collector. In both situation the main flow is deflected to inner or outer cone (placed at the outlet of the valve’s nozzle by Coanda effect. The paper deals with the numerical simulation of this axisymetric annular nozzle with integrated synthetic jet actuator. The aim of the work is influence examination of outer cone angle on deflection on main stream.

  15. Insulin receptor signaling in cones

    National Research Council Canada - National Science Library

    Rajala, Ammaji; Dighe, Radhika; Agbaga, Martin-Paul; Anderson, Robert E; Rajala, Raju V S


    .... To date there are no studies on the insulin receptor signaling in cones; however, mRNA levels of IR signaling proteins are significantly higher in cone-dominant neural retina leucine zipper (Nrl...

  16. Finite Coverings by Cones

    NARCIS (Netherlands)

    Tijs, S.H.; Reijnierse, J.H.


    This paper considers analogues of statements concerning compactness and finite coverings, in which the roles of spheres are replaced by cones. Furthermore, one of the finite covering results provides an application in Multi-Objective Programming; infinite sets of alternatives are reduced to finite

  17. Implications of Present Land Use Plan on Urban Growth and Environmental Sustainability in a Sub Saharan Africa City

    Directory of Open Access Journals (Sweden)

    Zakka Solomon Dyachia


    Full Text Available Land use, urban development and environmental sustainability have become an interesting research arena as urban development would change the city landscape as well as generate environmental degradation. This paper looks at the missing link between land use planning and urban growth, and it implications for environmental sustainability in a selected sub Saharan Africa city of Kaduna, Nigeria. We assessed urban growth from historical GIS data of the city to evaluate the urban expansion. At the same time, regression analysis was used to established relationship between carbon emission and traffic volume in the city. A city characterized by weak land use planning has created a gap leading to uncoordinated land use planning and uncontrolled physical growth. A steady increase of built up area of 8,400.31 hectares in 1982 to an area of 17,120.5 hectares in 2015 can be a reflection of the presence of uncontrolled urban expansion. The lack of coordination between land use planning and urban growth has resulted to environmental ills within the city. One among the ills, is ubiquitous traffic congestion within the city leading to high carbon (CO2 emission. Findings shows a strong connection between emission and volume of traffic. In addition to findings, is the decline of green areas in the city. By this findings, it is suggested that the modern concept of land use planning which embraces flexibility, public participation and integration of environmental issues should be entrenched and allow to take the lead in the process of urban growth.

  18. Estimating Potential GDP for the Romanian Economy and Assessing the Sustainability of Economic Growth: A Multivariate Filter Approach

    Directory of Open Access Journals (Sweden)

    Dan Armeanu


    Full Text Available In the current context of economic recovery and rebalancing, the necessity of modelling and estimating the potential output and output gap emerges in order to assess the quality and sustainability of economic growth, the monetary and fiscal policies, as well as the impact of business cycles. Despite the importance of potential GDP and the output gap, there are difficulties in reliably estimating them, as many of the models proposed in the economic literature are calibrated for developed economies and are based on complex macroeconomic relationships and a long history of robust data, while emerging economies exhibit high volatility. The object of this study is to develop a model in order to estimate the potential GDP and output gap and to assess the sustainability of projected growth using a multivariate filter approach. This trend estimation technique is the newest approach proposed by the economic literature and has gained wide acceptance with researchers and practitioners alike, while also being used by the IMF for Romania. The paper will be structured as follows. We first discuss the theoretical background of the model. The second section focuses on an analysis of the Romanian economy for the 1995–2013 time frame, while also providing a forecast for 2014–2017 and an assessment of the sustainability of Romania’s economic growth. The third section sums up the results and concludes.

  19. Ejecta evolution during cone impact

    KAUST Repository

    Marston, Jeremy


    We present findings from an experimental investigation into the impact of solid cone-shaped bodies onto liquid pools. Using a variety of cone angles and liquid physical properties, we show that the ejecta formed during the impact exhibits self-similarity for all impact speeds for very low surface tension liquids, whilst for high-surface tension liquids similarity is only achieved at high impact speeds. We find that the ejecta tip can detach from the cone and that this phenomenon can be attributed to the air entrainment phenomenon. We analyse of a range of cone angles, including some ogive cones, and impact speeds in terms of the spatiotemporal evolution of the ejecta tip. Using superhydrophobic cones, we also examine the entry of cones which entrain an air layer.

  20. Does E-Commerce Provide a Sustained Competitive Advantage? An Investigation of Survival and Sustainability in Growth-Oriented Enterprises

    Directory of Open Access Journals (Sweden)

    Qingyi Chen


    Full Text Available Enterprises should find a new business model for their development, so as to make better use of their own advantages. At the same time, with rapid development of the economy and of science technology, the competition between small and medium-sized enterprises (SMEs and large enterprises is inevitable, so it is very important for small and medium-sized enterprises to find better ways to improve their ability to compete. E-commerce is a new medium of commerce in this 21st century, so as to promote the quantity development of SMEs and enhance the risk management ability of enterprises. However, at present, many of China’s small and medium enterprises face many challenges in the process of electronic commerce’s development, such as, which factors hinder the performance of electronic commerce, and what aspect of enterprises should be improved? This paper is based on the above problems, using theoretical analysis and empirical research methods to explore the root of these problems and find the solutions. In the empirical section, we explore how e-commerce influences sales growth in the short- and long-term. Through analysis of e-commerce performance, we further explore the causality relationship and influence degree. The results show that: first, IT Investment is the most important factor to achieve success, what competitive advantage can be achieved largely depends on whether enterprises will effectively use the network technology; second, the expansion of the enterprise size can promote transaction volume increase of SMEs in the short term; third, internet availability has a positive effect on the trade volume of e-commerce, but the intensity is not obvious, and the effect is relatively stable.

  1. Cone Algorithm of Spinning Vehicles under Dynamic Coning Environment

    Directory of Open Access Journals (Sweden)

    Shuang-biao Zhang


    Full Text Available Due to the fact that attitude error of vehicles has an intense trend of divergence when vehicles undergo worsening coning environment, in this paper, the model of dynamic coning environment is derived firstly. Then, through investigation of the effect on Euler attitude algorithm for the equivalency of traditional attitude algorithm, it is found that attitude error is actually the roll angle error including drifting error and oscillating error, which is induced directly by dynamic coning environment and further affects the pitch angle and yaw angle through transferring. Based on definition of the cone frame and cone attitude, a cone algorithm is proposed by rotation relationship to calculate cone attitude, and the relationship between cone attitude and Euler attitude of spinning vehicle is established. Through numerical simulations with different conditions of dynamic coning environment, it is shown that the induced error of Euler attitude fluctuates by the variation of precession and nutation, especially by that of nutation, and the oscillating frequency of roll angle error is twice that of pitch angle error and yaw angle error. In addition, the rotation angle is more competent to describe the spinning process of vehicles under coning environment than Euler angle gamma, and the real pitch angle and yaw angle are calculated finally.

  2. Effectiveness of different antimicrobial agents in disinfection of guttapercha cones


    Ramos-Meléndez, Alexander; Escuela de Pregrado de la Facultad de Odontología de la Universidad Nacional Mayor de San Marcos; Ramos-Perfecto, Donald; Departamento Académico de Ciencias Básicas de la Facultad de Odontología de la Universidad Nacional Mayor de San Marcos, Perú.


    Objective: To determine the effectiveness of various antimicrobial agents in disinfection of gutta-percha, was the aim of the study. Methodology: 40 cones were cultivated in Brain Heart Infusion (BHI) culture medium at 37 ° C for 24 hours to see if there was bacterial growth. These same cones were divided into five groups to be introduced in the antimicrobial solutions: 2% chlorhexidine, hydrogen peroxide 3% sodium hypochlorite 2.5% ethyl alcohol 70% and 10% povidone iodine for a time immersi...

  3. Partnership for Sustainable Communities: Three Years of Helping Communities Achieve Their Visions for Growth and Prosperity (United States)

    This report from the Partnership for Sustainable Communities reports on the three years of progress since the Partnership started in 2009. It includes case studies of Partnership projects in communities around the country.

  4. Approaches for Planning and Implementing Sustainable Energy Growth in a Complex World: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Snyder, N.; Schwab, A.


    The subject of sustainable energy development has been widely discussed and debated in recent years. However, despite widespread interest, progress toward this goal has been limited. This paper will build on current thinking related to sustainable development, energy forecasting, and complexity theory and show how past roadmapping methodologies fall short. While proposing ways of thinking about our responses to global changes, we consider how we can create and discover the pathways through those unpredictable changes toward high global renewables penetration.

  5. Light cone matrix product

    Energy Technology Data Exchange (ETDEWEB)

    Hastings, Matthew B [Los Alamos National Laboratory


    We show how to combine the light-cone and matrix product algorithms to simulate quantum systems far from equilibrium for long times. For the case of the XXZ spin chain at {Delta} = 0.5, we simulate to a time of {approx} 22.5. While part of the long simulation time is due to the use of the light-cone method, we also describe a modification of the infinite time-evolving bond decimation algorithm with improved numerical stability, and we describe how to incorporate symmetry into this algorithm. While statistical sampling error means that we are not yet able to make a definite statement, the behavior of the simulation at long times indicates the appearance of either 'revivals' in the order parameter as predicted by Hastings and Levitov (e-print arXiv:0806.4283) or of a distinct shoulder in the decay of the order parameter.

  6. Cone rod dystrophies

    Directory of Open Access Journals (Sweden)

    Hamel Christian P


    Full Text Available Abstract Cone rod dystrophies (CRDs (prevalence 1/40,000 are inherited retinal dystrophies that belong to the group of pigmentary retinopathies. CRDs are characterized by retinal pigment deposits visible on fundus examination, predominantly localized to the macular region. In contrast to typical retinitis pigmentosa (RP, also called the rod cone dystrophies (RCDs resulting from the primary loss in rod photoreceptors and later followed by the secondary loss in cone photoreceptors, CRDs reflect the opposite sequence of events. CRD is characterized by primary cone involvement, or, sometimes, by concomitant loss of both cones and rods that explains the predominant symptoms of CRDs: decreased visual acuity, color vision defects, photoaversion and decreased sensitivity in the central visual field, later followed by progressive loss in peripheral vision and night blindness. The clinical course of CRDs is generally more severe and rapid than that of RCDs, leading to earlier legal blindness and disability. At end stage, however, CRDs do not differ from RCDs. CRDs are most frequently non syndromic, but they may also be part of several syndromes, such as Bardet Biedl syndrome and Spinocerebellar Ataxia Type 7 (SCA7. Non syndromic CRDs are genetically heterogeneous (ten cloned genes and three loci have been identified so far. The four major causative genes involved in the pathogenesis of CRDs are ABCA4 (which causes Stargardt disease and also 30 to 60% of autosomal recessive CRDs, CRX and GUCY2D (which are responsible for many reported cases of autosomal dominant CRDs, and RPGR (which causes about 2/3 of X-linked RP and also an undetermined percentage of X-linked CRDs. It is likely that highly deleterious mutations in genes that otherwise cause RP or macular dystrophy may also lead to CRDs. The diagnosis of CRDs is based on clinical history, fundus examination and electroretinogram. Molecular diagnosis can be made for some genes, genetic counseling is

  7. An Incentive-Based Solution of Sustainable Mobility for Economic Growth and CO2 Emissions Reduction

    Directory of Open Access Journals (Sweden)

    Manuel Herrador


    Full Text Available “Incentivized Sustainable Mobility” is a conceptual business model which involves four stakeholders: citizens, municipalities, commerce and mobility services. A platform named “ISUMO” (Incentivized Sustainable Mobility provides technological support to this business model, integrating a set of metaservices that unifies the existing ICTs of transportation plus a unique patented QR-based (Quick Response low-cost charging device for electric vehicles. Essentially, the system tracks and registers citizens’ transportation activities (anonymously and voluntarily and evaluates each through a scoring system while their ecological footprint is calculated. Afterwards, citizens are able to exchange their accumulated points for discount QR coupons, to be redeemed in the associated commerce in order to purchase their products or services. The breakthrough of this business model is that it enhances awareness of sustainable mobility practices, increasing their attractiveness as perceived by the stakeholders with diverse benefits; citizens (and indirectly, the municipalities initiate a new consumption pattern of “coupons culture” linked to sustainable mobility, the urban economy is stimulated, and the use of mobility services grows, providing a new business opportunity regarding electric vehicles. It is expected that continuous exploration of the model and implementation will contribute to sustainable social and economic development aiming at CO2 emissions reduction, headline targets of the Europe 2020 strategy.

  8. Toward Sustainable Economic Growth: A Spatial Panel Data Analysis of Regional Income Convergence in US BEA Economic Areas

    Directory of Open Access Journals (Sweden)

    Up Lim


    Full Text Available A question fundamental to sustainable economic growth is whether a poor region tends to grow faster than a rich one, such that the poor region catches up with the rich region in terms of the level of per capita income. In this article, we apply the spatial panel data approach to the analysis of regional income convergence across 177 economic areas in the contiguous US states over the period from 1969 to 2009. Using data on per capita incomes in the functionally defined economic areas, we find that the absolute value of the estimated coefficient of the initial per capita income decreases in the spatial and time-period fixed effects spatial lag model and increases in the spatial and time-period fixed effects spatial error model. This result implies that the growth rate in a specific economic area will be not only directly affected by an exogenous shock introduced into that economic area but also be impacted more by both the indirect effects of the first-order neighboring economic areas and the induced effects of the higher-order neighboring economic areas. This gives helpful hints on the issue of spatial interaction and regional policy coordination to start a virtuous circle of sustainable economic growth.


    Directory of Open Access Journals (Sweden)

    Arim Nasim


    Full Text Available This study aims to determine the effect of Profit Margin, Assets Turnover and Leverage on Sustainable Growth Rate. The variables used are profit margin, asset turnover and leverage as independent variable and sustainable growth rate as dependent variable. This study also aims to describe the state of profit margin projected by Net Profit Margin (NPM, asset turnover proxied by Total Assets Turnover (TATO, leverage which is proxied by Debt to Equity Ratio (DER and Sustainable Growth Rate (SGR Service sector. This research was conducted on service sector companies listed in Indonesia Stock Exchange 2010-2012.Data obtained from website Bursa Efek Indonesia.Teknik data analysis used is multiple linear regression and use t-statistics to test the influence of each independent variable to variable Dependent partially.Previously done classical assumption test that includes data normality test, multicolinierity test, heteroskedastisitas test and autocorrelation test.Based on data normality test, multicolinierity test, heteroscedasticity test and autocorrelation test did not found any variables that deviate from the classical assumption.From the results of research Shows that profit margin positively affect sustainable growth rate, asset turnover have positive effect to sustainable growth rate, and leverage have positive effect to sustainable growth rate.

  10. The sustainability debate: idealism versus conformism - the controversy over economic growth

    NARCIS (Netherlands)

    Verstegen, S.W.; Hanekamp, J.C.


    Since the publication of Our Common Future in 1987, scientists have struggled with the concept of sustainability and many definitions are now in existence. However, one can differentiate between a much smaller series of themes. Working from these definitions, we focus on six such themes. We will

  11. Developing robust crop plants for sustaining growth and yield under adverse climatic changes (United States)

    Agricultural production and quality are expected to suffer from adverse changes in climatic conditions, including global warming, and this will affect worldwide human and animal food security. Global warming has been shown to negatively impact crop yield and therefore will affect sustainability of a...

  12. CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration.

    Directory of Open Access Journals (Sweden)

    Yiwen Li


    Full Text Available Cone photoreceptors are responsible for color and central vision. In the late stage of retinitis pigmentosa and in geographic atrophy associated with age-related macular degeneration, cone degeneration eventually causes loss of central vision. In the present work, we investigated cone degeneration secondary to rod loss in the S334ter-3 transgenic rats carrying the rhodopsin mutation S334ter.Recombinant human ciliary neurotrophic factor (CNTF was delivered by intravitreal injection to the left eye of an animal, and vehicle to the right eye. Eyes were harvested 10 days after injection. Cone outer segments (COS, and cell bodies were identified by staining with peanut agglutinin and cone arrestin antibodies in whole-mount retinas. For long-term treatment with CNTF, CNTF secreting microdevices were implanted into the left eyes at postnatal day (PD 20 and control devices into the right eyes. Cone ERG was recorded at PD 160 from implanted animals. Our results demonstrate that an early sign of cone degeneration is the loss of COS, which concentrated in many small areas throughout the retina and is progressive with age. Treatment with CNTF induces regeneration of COS and thus reverses the degeneration process in early stages of cone degeneration. Sustained delivery of CNTF prevents cones from degeneration and helps them to maintain COS and light-sensing function.Loss of COS is an early sign of secondary cone degeneration whereas cell death occurs much later. At early stages, degenerating cones are capable of regenerating outer segments, indicating the reversal of the degenerative process. Sustained delivery of CNTF preserves cone cells and their function. Long-term treatment with CNTF starting at early stages of degeneration could be a viable strategy for preservation of central vision for patients with retinal degenerations.

  13. Gazing into the crystal ball: future considerations for ensuring sustained growth of the functional food and nutraceutical marketplace. (United States)

    Marinangeli, Christopher P F; Jones, Peter J H


    Over the last decade the concept of functional foods and nutraceuticals (FFN) has gained support from various stakeholders including the food industry, scientific and academic community, government institutions or regulators, producers and consumers. However, as one begins to evaluate the global FFN industry, several issues emerge including (i) a lack of consensus across jurisdictions for acknowledging safe and efficacious FFN, (ii) challenges regarding the classification of novel food-derived bioactives as FFN or drugs, and (iii) a disconnect between nutrient requirements and dosages of FFN required to facilitate health benefits. The objectives of the present review are to discuss the role of existing stakeholders within the FFN marketplace and identify performance indicators for growth within the FFN sector. In addition, the following report provides feasible resolutions to present and future challenges facing the global FFN industry to ensure sustained long-term growth.

  14. Landscape urbanization and economic growth in China: positive feedbacks and sustainability dilemmas. (United States)

    Bai, Xuemei; Chen, Jing; Shi, Peijun


    Accelerating urbanization has been viewed as an important instrument for economic development and reducing regional income disparity in some developing countries, including China. Recent studies (Bloom et al. 2008) indicate that demographic urbanization level has no causal effect on economic growth. However, due to the varying and changing definition of urban population, the use of demographic indicators as a sole representing indicator for urbanization might be misleading. Here, we re-examine the causal relationship between urbanization and economic growth in Chinese cities and provinces in recent decades, using built-up areas as a landscape urbanization indicator. Our analysis shows that (1) larger cities, both in terms of population size and built-up area, and richer cities tend to gain more income, have larger built-up area expansion, and attract more population, than poorer cities or smaller cities; and (2) that there is a long-term bidirectional causality between urban built-up area expansion and GDP per capita at both city and provincial level, and a short-term bidirectional causality at provincial level, revealing a positive feedback between landscape urbanization and urban and regional economic growth in China. Our results suggest that urbanization, if measured by a landscape indicator, does have causal effect on economic growth in China, both within the city and with spillover effect to the region, and that urban land expansion is not only the consequences of economic growth in cities, but also drivers of such growth. The results also suggest that under its current economic growth model, it might be difficult for China to control urban expansion without sacrificing economic growth, and China's policy to stop the loss of agricultural land, for food security, might be challenged by its policy to promote economic growth through urbanization.

  15. Innovative paths for providing green energy for sustainable global economic growth (United States)

    Singh, Rajendra; Alapatt, G. F.


    According to United Nation, world population may reach 10.1 billion by the year 2100. The fossil fuel based global economy is not sustainable. For sustainable global green energy scenario we must consider free fuel based energy conversion, environmental concerns and conservation of water. Photovoltaics (PV) offers a unique opportunity to solve the 21st century's electricity generation because solar energy is essentially unlimited and PV systems provide electricity without any undesirable impact on the environment. Innovative paths for green energy conversion and storage are proposed in areas of R and D, manufacturing and system integration, energy policy and financing. With existing silicon PV system manufacturing, the implementation of new innovative energy policies and new innovative business model can provide immediately large capacity of electricity generation to developed, emerging and underdeveloped economies.

  16. Effects of light environment during growth on the expression of cone opsin genes and behavioral spectral sensitivities in guppies (Poecilia reticulata). (United States)

    Sakai, Yusuke; Ohtsuki, Hajime; Kasagi, Satoshi; Kawamura, Shoji; Kawata, Masakado


    The visual system is important for animals for mate choice, food acquisition, and predator avoidance. Animals possessing a visual system can sense particular wavelengths of light emanating from objects and their surroundings and perceive their environments by processing information contained in these visual perceptions of light. Visual perception in individuals varies with the absorption spectra of visual pigments and the expression levels of opsin genes, which may be altered according to the light environments. However, which light environments and the mechanism by which they change opsin expression profiles and whether these changes in opsin gene expression can affect light sensitivities are largely unknown. This study determined whether the light environment during growth induced plastic changes in opsin gene expression and behavioral sensitivity to particular wavelengths of light in guppies (Poecilia reticulata). Individuals grown under orange light exhibited a higher expression of long wavelength-sensitive (LWS) opsin genes and a higher sensitivity to 600-nm light than those grown under green light. In addition, we confirmed that variations in the expression levels of LWS opsin genes were related to the behavioral sensitivities to long wavelengths of light. The light environment during the growth stage alters the expression levels of LWS opsin genes and behavioral sensitivities to long wavelengths of light in guppies. The plastically enhanced sensitivity to background light due to changes in opsin gene expression can enhance the detection and visibility of predators and foods, thereby affecting survival. Moreover, changes in sensitivities to orange light may lead to changes in the discrimination of orange/red colors of male guppies and might alter female preferences for male color patterns.

  17. Dynamics of turtle cones. (United States)

    Naka, K I; Itoh, M A; Chappell, R L


    The response dynamics of turtle photoreceptors (cones) were studied by the cross-correlation method using a white-noise-modulated light stimulus. Incremental responses were characterized by the kernels. White-noise-evoked responses with a peak-to-peak excursion of greater than 5 mV were linear, with mean square errors of approximately 8%, a degree of linearity comparable to the horizontal cell responses. Both a spot (0.17 mm diam) and a large field of light produced almost identical kernels. The amplitudes of receptor kernels obtained at various mean irradiances fitted approximately the Weber-Fechner relationship and the mean levels controlled both the amplitude and the response dynamics; kernels were slow and monophasic at low mean irradiance and were fast and biphasic at high mean irradiance. This is a parametric change and is a piecewise linearization. Horizontal cell kernels evoked by the small spot of light were monophasic and slower than the receptor kernels produced by the same stimulus. Larger spots of light or a steady annular illumination transformed the slow horizontal cell kernel into a fast kernel similar to those of the receptors. The slowing down of the kernel waveform was modeled by a simple low-pass circuit and the presumed feedback from horizontal cells onto cones did not appear to play a major role.

  18. An exploratory Study on development of Maestro Leadership capacities for inclusive growth and sustainable future


    Dr. Renita Dubey


    Globalization is a complex phenomenon that has far reaching effects. Nowadays, managers need to understand social, economic, political and legal ramifications of global markets. This paper is devoted to advocating sustainable development and competitive advantage through showcase of right leadership talent in organizations. It is very important that leaders must feel like citizens of the world who have an expanded and well- defined vision. I strongly feel that this study on leadership excelle...

  19. Tourism for pro-poor and sustainable growth: economic analysis of tourism projects


    Lin, Tun; De Guzman, Franklin


    Despite the increasing importance of tourism in economic development and the rise of “pro-poor” tourism development strategies, properly designing and implementing tourism projects remain generally a difficult process. There are both theoretical and practical challenges in justifying public sector investments in tourism and properly measuring the projects’ benefits and sustainability. There is a need to come up with an analytical framework that would address these challenges and help evaluate...

  20. From unlimited growth to sustainable energy. The origin of operational patterns by means of social selection

    Energy Technology Data Exchange (ETDEWEB)

    Peura, P.


    This doctoral thesis is based on four peer reviewed articles, which together make a coherent longitudinal research and knowledge creating process, with conceptual integration and dialectical reasoning as its corner stones. The thesis is based on zooming in from large scale thinking - philosophy and worldview - towards smaller scale issues, first in order to understand, then to deepen knowledge through research, then to search for solutions for clearly explicated problems, and finally to implement the findings in practice. The logical framework is as follows: The state of the global environment is approaching a point where the whole of humankind is in danger. These issues are widely discussed and analysed. The change towards more sustainable development will be a long societal process, and it will be essential to understand the characteristics and dialectics of the process. The author presents and analyses his three layer model of societal evolution. The change of making humankind more sustainable creates practical needs - real actions will be necessary - but above all, it creates a need to develop scientific understanding, which is briefly discussed. The production of energy has traditionally been one of the core issues concerning the effect humankind has on the environment, and in the process of change, the potential reform of the energy sector will be in a key position. The main part of the thesis' empirical material concerns the energy sector and its potential shift towards the principle of sustainable energy. (orig.)

  1. Does infill outperform climate-adaptive growth policies in meeting sustainable urbanization goals? : A scenario-based study in California, USA

    NARCIS (Netherlands)

    Thorne, James; Ferreira Dos Santos, M.J.; Bjorkman, Jacquelyn H.; Soong, O; Ikegami, M; Seo, C; Hannah, Lee

    Land allocation for urban growth is central to sustainable development strategy because urban growth can impact space available for food production, ecosystem services and biodiversity conservation. Urbanization is a growing stressor due the 2.5 billion additional people projected to live in urban

  2. Assessing the Sustainability of Credit Growth: The case of Central and Eastern European Countries

    Directory of Open Access Journals (Sweden)

    Coudert, Virginie


    Full Text Available Credit growth rates as high as 30% or 50% a year were observed in some Central Eastern European countries (CEECs in 2006-2007, such as the Baltic States, Bulgaria or Romania. This strong credit growth could have been due to the catching-up process but could also have been excessive, paving the way to the credit crunch that followed the crisis in 2008-2009. We try to assess the excessiveness of credit by applying a number of methods. First, we consider the gap between current credit and its long-term trend and we find some signs of credit booms, in several CEECs in 2005-2007. Second, we assess the "normal" growth of credit with regard to fundamentals through econometric estimations. Credit growth is also shown to have been excessive in several countries just before the 2008-2009 financial crisis.

  3. A Cycle-Adjusted Fiscal Rule for Sustainable and More Equitable Growth in Argentina


    Zúñiga, Jimena; Capello, Marcelo; Butler, Inés; Grión, Néstor


    This paper seeks to identify the most promising fiscal strategy to boost long-term economic growth in Argentina and quantify its effects. To this end, the authors updated a growth-diagnostics study for Argentina and corroborated that low appropriability of social returns and insufficient public infrastructure are key constraints to private investment. Further, low appropriability stands out among the key constraints to productivity-enhancing activities. Because low appropriability is largely ...

  4. Efficacy of different concentrations of sodium hypochlorite and chlorhexidine in disinfection of contaminated Resilon cones. (United States)

    Zand, V; Salem-Milani, A; Shahi, S; Akhi, M-T; Vazifekhah, S


    The aim of this study was to evaluate the effectiveness of different concentrations of Chlorhexidine (CHX) and sodium hypochlorite (NaOCl) in disinfecting contaminated Resilon cones within one minute. Fifty Resilon cones were divided into seven experimental groups and three control groups of 5 cones each. The cones of experimental groups were contaminated with E. faecalis and subsequently disinfected with different concentrations of NaOCl or CHX. The cones were then transferred into glass tubes containing thioglycollate media and incubated for 7 days. The tubes were examined for turbidity every 24 hours, and if bacterial growth occurred, samples were plated, incubated, gram stained and observed under microscope to confirm E. faecalis growth. Negative, positive, and washing control groups were also used. All the positive and washing control showed profound E.faecalis growth. All the cones disinfected with CHX showed bacterial growth; however, no E. faecalis growth occurred in any samples disinfected with NaOCl. Sodium hypochlorite, at concentrations of 0.5 to 5.25%, is an effective agent for disinfection of contaminated Resilon cones within one minute; however, chlorhexidine is unable to disinfect Resilon cones during one-minute exposure.

  5. Aerodynamic Rear Cone for Trucks (United States)

    Bullman, J.


    Wind-inflated cone reduces turbulence that ordinarily occurs in air just behind square-back truck traveling at high speed. Wind around truck would enter slits in folded cone and automatically deploy it. Energy lost to air turbulence greatly reduced, and fuel consumed by truck reduced accordingly. In addition, less air turbulence means less disturbance to nearby vehicles on highway.

  6. Does Rapid and Sustained Economic Growth Lead to Convergence in Health Resources: The Case of China From 1980 to 2010. (United States)

    Liang, Di; Zhang, Donglan; Huang, Jiayan; Schweitzer, Stuart


    China's rapid and sustained economic growth offers an opportunity to ask whether the advantages of growth diffuse throughout an economy, or remain localized in areas where the growth has been the greatest. A critical policy area in China has been the health system, and health inequality has become an issue that has led the government to broaden national health insurance programs. This study investigates whether health system resources and performance have converged over the past 30 years across China's 31 provinces. To examine geographic variation of health system resources and performance at the provincial level, we measure the degree of sigma convergence and beta convergence in indicators of health system resources (structure), health services utilization (process), and outcome. All data are from officially published sources: the China Health Statistics Year Book and the China Statistics Year Book. Sigma convergence is found for resource indicators, whereas it is not observed for either process or outcome indicators, indicating that disparities only narrowed in health system resources. Beta convergence is found in most indicators, except for 2 procedure indicators, reflecting that provinces with poorer resources were catching up. Convergence found in this study probably reflects the mixed outcome of government input, and market forces. Thus, left alone, the equitable distribution of health care resources may not occur naturally during a period of economic growth. Governmental and societal efforts are needed to reduce geographic health variation and promote health equity. © The Author(s) 2016.

  7. Is rapid growth in Internet usage environmentally sustainable for Australia? An empirical investigation. (United States)

    Salahuddin, Mohammad; Alam, Khorshed; Ozturk, Ilhan


    This study estimates the short- and long-run effects of Internet usage and economic growth on carbon dioxide (CO2) emissions using annual time series macro data for Australia for the period 1985-2012. Autoregressive distributive lag (ARDL) bounds and Gregory-Hansen structural break cointegration tests are applied. ARDL estimates indicate no significant long-run relationship between Internet usage and CO2 emissions, which implies that the rapid growth in Internet usage is still not an environmental threat for Australia. The study further indicates that higher level of economic growth is associated with lower level of CO2 emissions; however, Internet usage and economic growth have no significant short-run relationship with CO2 emissions. Financial development has both short-run and long-run significant positive association with CO2 emissions. The findings offer support in favor of energy efficiency gains and a reduction in energy intensity in Australia. However, impulse response and variance decomposition analysis suggest that Internet usage, economic growth and financial development will continue to impact CO2 emissions in the future, and as such, this study recommends that in addition to the existing measures to combat CO2 emissions, Australia needs to exploit the potential of the Internet not only to reduce its own carbon footprint but also to utilize information and communication technology (ICT)-enabled emissions abatement potential to reduce emissions in various other sectors across the economy, such as, power, renewable energy especially in solar and wind energy, agriculture, transport and service.

  8. Catalyst-Free Plasma Enhanced Growth of Graphene from Sustainable Sources. (United States)

    Jacob, Mohan V; Rawat, Rajdeep S; Ouyang, Bo; Bazaka, Kateryna; Kumar, D Sakthi; Taguchi, Dai; Iwamoto, Mitsumasa; Neupane, Ram; Varghese, Oomman K


    Details of a fast and sustainable bottom-up process to grow large area high quality graphene films without the aid of any catalyst are reported in this paper. We used Melaleuca alternifolia, a volatile natural extract from tea tree plant as the precursor. The as-fabricated graphene films yielded a stable contact angle of 135°, indicating their potential application in very high hydrophobic coatings. The electronic devices formed by sandwiching pentacene between graphene and aluminum films demonstrated memristive behavior, and hence, these graphene films could find use in nonvolatile memory devices also.

  9. Convergent innovation for sustainable economic growth and affordable universal health care: innovating the way we innovate. (United States)

    Dubé, Laurette; Jha, Srivardhini; Faber, Aida; Struben, Jeroen; London, Ted; Mohapatra, Archisman; Drager, Nick; Lannon, Chris; Joshi, P K; McDermott, John


    This paper introduces convergent innovation (CI) as a form of meta-innovation-an innovation in the way we innovate. CI integrates human and economic development outcomes, through behavioral and ecosystem transformation at scale, for sustainable prosperity and affordable universal health care within a whole-of-society paradigm. To this end, CI combines technological and social innovation (including organizational, social process, financial, and institutional), with a special focus on the most underserved populations. CI takes a modular approach that convenes around roadmaps for real world change-a portfolio of loosely coupled complementary partners from the business community, civil society, and the public sector. Roadmaps serve as collaborative platforms for focused, achievable, and time-bound projects to provide scalable, sustainable, and resilient solutions to complex challenges, with benefits both to participating partners and to society. In this paper, we first briefly review the literature on technological innovation that sets the foundations of CI and motivates its feasibility. We then describe CI, its building blocks, and enabling conditions for deployment and scaling up, illustrating its operational forms through examples of existing CI-sensitive innovation. © 2014 The New York Academy of Sciences.

  10. Forced sustained swimming exercise at optimal speed enhances growth of juvenile yellowtail kingfish (Seriola lalandi)

    NARCIS (Netherlands)

    Palstra, A.P.; Mes, D.; Kusters, K.; Roques, J.A.C.; Flik, G.; Kloet, K.; Blonk, R.J.W.


    Swimming exercise at optimal speed may optimize growth performance of yellowtail kingfish in a recirculating aquaculture system. Therefore, optimal swimming speeds (U-opt in m s(-1) or body lengths s(-1), BL s(-1)) were assessed and then applied to determine the effects of long-term forced and

  11. Balancing growth, harvest, and consumption: a regional response to the national issue of forest sustainability (United States)

    Stephen R. Shifley; Neal H. Sullivan


    The 46 million people who live in the North Central Region of the United States account for about 17 percent of the wood annually consumed in the United States. The region contains 14 percent of the nation's timberland, but annual timber growth is equivalent to only 10 percent of nation's total. Annual timber harvest is equivalent to only 7 percent of the...

  12. Effects of stocking density and sustained aerobic exercise on growth, energetics and welfare of rainbow trout

    DEFF Research Database (Denmark)

    McKenzie, David J.; Höglund, Erik; Dupont-Prinet, A.


    Two stocking densities, “low” (L, between ~19 and ~25 kgm−3) and “high” (H, between ~75 and ~100 kgm−3) were compared for effects on specific growth rate (SGR), feed conversion, energetics and welfare of rainbow trout reared at 14 °C either in static water (S) or swimming in a gentle current of ~...

  13. Capromorelin increases food consumption, body weight, growth hormone, and sustained insulin-like growth factor 1 concentrations when administered to healthy adult Beagle dogs. (United States)

    Zollers, B; Rhodes, L; Smith, R G


    This study's objective was to determine the effects in dogs of oral capromorelin, a ghrelin agonist, at different doses for 7 days on food consumption, body weight and serum concentrations of growth hormone (GH), insulin-like growth factor 1 (IGF-1), and cortisol. Adult Beagles (n = 6) were dosed with placebo BID, capromorelin at 3.0 mg/kg SID, 4.5 mg/kg SID, or 3.0 mg/kg BID. Food consumption, body weight, serum capromorelin, GH, IGF-1, and cortisol were measured at intervals on days 1, 4, 7, and 9. Capromorelin increased food consumption and body weight compared to placebo and caused increased serum GH, which returned to the baseline by 8 h postdose. The magnitude of the GH increase was less on days 4 and 7 compared to Day 1. IGF-1 concentrations increased on Day 1 in capromorelin-treated dogs and this increase was sustained through Day 7. Serum cortisol increased postdosing and returned to the baseline concentrations by 8 h. The magnitude of the increase was less on days 4 and 7 compared to Day 1. A dose of 3 mg/kg was chosen for further study in dogs based on this dose causing increased food consumption and sustained IGF-1 serum concentrations that may increase lean muscle mass when administered over extended periods. © 2016 The Authors. Journal of Veterinary Pharmacology and Therapeutics Published by John Wiley & Sons Ltd.

  14. Incorporating Role of Stakeholders into Corporate CSR Strategy For Sustainable Growth: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    Tanggamani Vani


    Full Text Available In today’s modern day context, Corporate Social Responsibility (CSR become the mantra for businesses as it can be seen as a strategic approach for firms to be succeed in their business endeavours. Hence, it remains the most widely used concept to refer to organizational- stakeholder relationships. An understanding about a stakeholder approach to CSR is an important means for a firm to enhance their commitment to operate in an economically, socially and environmentally sustainable manner. In support with above arguments, this article presents a theoretical proposition based on stakeholder theory for better CSR and firm performance. By drawing upon classic work in the field, the paper offers conceptual discussion and then systematically develops a means of stakeholder approach into corporate CSR strategy. The aim of this paper is to demonstrates the need for a firm to enhance further understanding about the role of stakeholders in the context of corporate CSR strategy, which is increasingly necessary in view of the fact that business entities are absolutely essential for economic development, but at the same time, their business activities pose a huge impact to society and the environment. Thus, firm's CSR disclosure is a pivotal tool to establish a relationship of working together with the stakeholders that ensures mutual benefit and continue to be a firm that is needed by society. This article contributes to the literature by providing a fundamental explanation of how a business should embrace responsibility for the impact of its activities on the stakeholders across various levels of the value chain. By doing so, firms are offered a means to take a much more proactive approach to CSR through the stakeholder approach which is precisely helpful in measuring the effectiveness of any CSR initiative on the society to foster business sustainability.


    Directory of Open Access Journals (Sweden)



    Full Text Available This paper intends to render several important factors of impact on economic growth and to describe the particular types of relationships of the latter with each one of its influencing elements. In order to correctly determine such issue, we have resorted to three carefully selected models that have been estimated and compared so as to identify the most adequate and representative regression. For this purpose we have performed an analysis based on cross-section annual data for 105 countries spread all over the world. After having tested and rejected certain exogenous variables initially considered, such as imports or exports, we have finally retained the external debt and foreign direct investments as explanatory items of the dependent variable. The results revealed that both of them positively affect the gross domestic product of the analysed countries, this one being inelastic in relation to the exogenous variables considered. Even if the relationship between the economic growth and the external debt of a country is usually negative, as the money exit out of the country due to the debt service causes non-achieved potential investments, yet, there is an inflexion point up to which the external debt has a positive influence on economic growth by the increase of the investments funds acquired as result of the external credit contracting, this being the case reflected by our study. As for the relationship existing between foreign direct investments and GDP, the economic theory confirms that FDI and economic growth are directly correlated, the former contributing to technical progress, production increase and, finally, to the improvement of the living standard.

  16. Eruptive and Geomorphic Processes at the Lathrop Wells Scoria Cone

    Energy Technology Data Exchange (ETDEWEB)

    G. Valentine; D.J. Krier; F.V. Perry; G. Heiken


    The {approx}80 ka Lathrop Wells volcano (southern Nevada, U.S.A.) preserves evidence for a range of explosive processes and emplacement mechanisms of pyroclastic deposits and lava fields in a small-volume basaltic center. Early cone building by Strombolian bursts was accompanied by development of a fan-like lava field reaching {approx}800 m distance from the cone, built upon a gently sloping surface. Lava flows carried rafts of cone deposits, which provide indirect evidence for cone facies in lieu of direct exposures in the active quarry. Subsequent activity was of a violent Strombolian nature, with many episodes of sustained eruption columns up to a few km in height. These deposited layers of scoria lapilli and ash in different directions depending upon wind direction at the time of a given episode, reaching up to {approx}20 km from the vent, and also produced the bulk of the scoria cone. Lava effusion migrated from south to north around the eastern base of the cone as accumulation of lavas successively reversed the topography at the base of the cone. Late lavas were emplaced during violent Strombolian activity and continued for some time after explosive eruptions had waned. Volumes of the eruptive products are: fallout--0.07 km{sup 3}, scoria cone--0.02 km{sup 3}, and lavas--0.03 km{sup 3}. Shallow-derived xenolith concentrations suggest an upper bound on average conduit diameter of {approx}21 m in the uppermost 335 m beneath the volcano. The volcano was constructed over a period of at least seven months with cone building occurring only during part of that time, based upon analogy with historical eruptions. Post-eruptive geomorphic evolution varied for the three main surface types that were produced by volcanic activity: (1) scoria cone, (2) low relief surfaces (including lavas) with abundant pyroclastic material, and (3) lavas with little pyroclastic material. The role of these different initial textures must be accounted for in estimating relative ages of

  17. Green Growth, Resources and Resilience. Environmental Sustainability in Asia and the Pacific

    Energy Technology Data Exchange (ETDEWEB)



    While regional countries are driving the global 'green growth' agenda, policymakers are facing a new economic reality and heightened uncertainty. The challenge of eco-efficient economic growth and inclusive resource use is critical and growing in several countries. Fundamental, rather than incremental changes are needed. Governments must therefore take the lead in re-orienting both the 'visible' and the 'invisible' economic infrastructure. At the same time the implications of heightened uncertainty and risk for policymaking requires more attention. This report highlights changes in the policy landscape that have taken place since 2005, focuses on the emerging challenges of resources and resilience, presents new regional and country data produced by the Commonwealth Scientific and Industrial Research Organisation of Australia (CSIRO) and UNEP, and provides insights to key policy arenas for greening of growth. The report is the sixth in a series of reports produced every five years by ESCAP for the Ministerial Conference on Environment and Development. It is also the third in the ADB's Asian Environment Outlook series. This year, it complements a UNEP report: Resource Efficiency: Economics and Outlook for Asia and the Pacific (Canberra, CSIRO Publishing), providing new insights into regional use of key resources, and what that means for economies in the Asia-Pacific Region. The report is also intended to support stakeholders preparing for Rio+20.

  18. Hype, harmony and human factors: applying user-centered design to achieve sustainable telehealth program adoption and growth. (United States)

    Rossos, P G; St-Cyr, O; Purdy, B; Toenjes, C; Masino, C; Chmelnitsky, D


    Despite decades of international experience with the use of information and communication technologies in healthcare delivery, widespread telehealth adoption remains limited and progress slow. Escalating health system challenges related to access, cost and quality currently coincide with rapid advancement of affordable and reliable internet based communication technologies creating unprecedented opportunities and incentives for telehealth. In this paper, we will describe how Human Factors Engineering (HFE) and user-centric elements have been incorporated into the establishment of telehealth within a large academic medical center to increase acceptance and sustainability. Through examples and lessons learned we wish to increase awareness of HFE and its importance in the successful implementation, innovation and growth of telehealth programs.

  19. Cone and Seed Maturation of Southern Pines (United States)

    James P. Barnett


    If slightly reduced yields and viability are acceptable, loblolly and slash cone collections can begin 2 to 3 weeks before maturity if the cones are stored before processing. Longleaf(P. palestris Mill.) pine cones should be collected only when mature, as storage decreased germination of seeds from immature cones. Biochemical analyses to determine reducing sugar...

  20. Plant growth-promoting actinobacteria: a new strategy for enhancing sustainable production and protection of grain legumes. (United States)

    Sathya, Arumugam; Vijayabharathi, Rajendran; Gopalakrishnan, Subramaniam


    Grain legumes are a cost-effective alternative for the animal protein in improving the diets of the poor in South-East Asia and Africa. Legumes, through symbiotic nitrogen fixation, meet a major part of their own N demand and partially benefit the following crops of the system by enriching soil. In realization of this sustainability advantage and to promote pulse production, United Nations had declared 2016 as the "International Year of pulses". Grain legumes are frequently subjected to both abiotic and biotic stresses resulting in severe yield losses. Global yields of legumes have been stagnant for the past five decades in spite of adopting various conventional and molecular breeding approaches. Furthermore, the increasing costs and negative effects of pesticides and fertilizers for crop production necessitate the use of biological options of crop production and protection. The use of plant growth-promoting (PGP) bacteria for improving soil and plant health has become one of the attractive strategies for developing sustainable agricultural systems due to their eco-friendliness, low production cost and minimizing consumption of non-renewable resources. This review emphasizes on how the PGP actinobacteria and their metabolites can be used effectively in enhancing the yield and controlling the pests and pathogens of grain legumes.

  1. Global health and development: conceptualizing health between economic growth and environmental sustainability. (United States)

    Borowy, Iris


    After World War II, health was firmly integrated into the discourse about national development. Transition theories portrayed health improvements as part of an overall development pattern based on economic growth as modeled by the recent history of industrialization in high-income countries. In the 1970s, an increasing awareness of the environmental degradation caused by industrialization challenged the conventional model of development. Gradually, it became clear that health improvements depended on poverty-reduction strategies including industrialization. Industrialization, in turn, risked aggravating environmental degradation with its negative effects on public health. Thus, public health in low-income countries threatened to suffer from lack of economic development as well as from the results of global economic development. Similarly, demands of developing countries risked being trapped between calls for global wealth redistribution, a political impossibility, and calls for unrestricted material development, which, in a world of finite land, water, air, energy, and resources, increasingly looked like a physical impossibility, too. Various international bodies, including the WHO, the Brundtland Commission, and the World Bank, tried to capture the problem and solution strategies in development theories. Broadly conceived, two models have emerged: a "localist model," which analyzes national health data and advocates growth policies with a strong focus on poverty reduction, and a "globalist" model, based on global health data, which calls for growth optimization, rather than maximization. Both models have focused on different types of health burdens and have received support from different institutions. In a nutshell, the health discourse epitomized a larger controversy regarding competing visions of development.

  2. Fair Trade in Sustainable Development. The Potential for Fair Trade Market Growth in Poland

    Directory of Open Access Journals (Sweden)

    Grażyna Śmigielska


    Full Text Available The paper presents the concept of Fair Trade, which is considered an alternative to conventional trade, and becomes increasingly popular in the Western countries. In addition, some results of empirical research, conveyed in Poland and aimed at diagnosis and assessment of Fairtrade products market, are provided. Fair trade is analysed not only in the broad theoretical context which shows its contribution to sustainable development and relation to corporate social responsibility, but also in the framework of supply chains management. The benefits from the Fairtrade label, including transaction costs reduction are indicated. The assumption is that to achieve them, consumer acceptance of the idea and willingness to buy Fairtrade products are necessary. The empirical research was focused on answering the question whether a market niche for Fairtrade goods exists in Poland and how to develop it by the means of communication tools. The market niche, although very small, has been identified and described. It is apparent that, in order to develop it, a public policy, aimed at raising the awareness of Fair Trade idea, is necessary as well as marketing activities like social marketing Internet campaigns and better and more prominently products display.

  3. Intratumoral chemotherapy with a sustained-release drug delivery system inhibits growth of human pancreatic cancer xenografts. (United States)

    Smith, J P; Stock, E; Orenberg, E K; Yu, N Y; Kanekal, S; Brown, D M


    This study provides the first evidence that treatment of human pancreatic adenocarcinoma is markedly improved by the intratumoral administration of chemotherapeutic agents in a novel drug delivery system. The effect of chemotherapeutic agents delivered in a sustained-release, protein-based, injectable gel was evaluated on the growth of human pancreatic adenocarcinoma cell line, BxPC-3. In vitro chemosensitivity of BxPC-3 cells exposed for 24 or 72 h to fluorouracil (0.01-5 mM), cisplatin or doxorubicin (0.1-50 microM) and floxuridine, vinblastine, mitomycin or paclitaxel (1.0-100 microM) was compared with that of untreated cells. In vitro chemosensitivity was also studied with fluorouracil and mitomycin in the poorly differentiated PANC-1, human pancreatic cancer cell line. Survival was determined after 7-10 days. All drugs decreased cell growth in a dose-dependent fashion. The efficacy of fluorouracil, cisplatin and doxorubicin increased with prolonged exposure, rendering these drugs most appropriate for a sustained-release preparation. For in vivo studies, athymic nude mice bearing BxPC-3 xenografts were treated either with fluorouracil, cisplatin or doxorubicin in the therapeutic injectable gel containing epinephrine or with vehicle alone administered intratumorally on days 1 and 4. After 28 days, the mice were sacrificed and tumors dissected and weighed. Tumors in mice treated with the injectable gel decreased in size by 72-79% compared with tumors in untreated controls and tumors treated with vehicle alone. Intratumoral injection of drug solution and intraperitoneal injection of drug in the injectable gel did not change tumor size compared with controls. In a drug-retention study, mice were injected intratumorally with [3H]fluorouracil either in the injectable gel or in solution. Sustained radioactivity was observed in tumors injected with the gel, and, conversely, greater radioactivity was detected in the liver and kidneys in mice receiving the radiolabeled

  4. Dirac fermions on graphite cones

    CERN Document Server

    Osipov, V A


    The electronic structure of graphitic cones is investigated within the self-consistent field-theory model. The local and total density of states near the apex is found for cones of different opening angles. For extended electronic states, total density of states is found to vanish at the Fermi level at any opening angles more than 60 deg. In turn, for power-law localized states, normalized zero-energy modes are shown to emerge

  5. Assessing the Impacts of Chinese Sustainable Ground Transportation on the Dynamics of Urban Growth: A Case Study of the Hangzhou Bay Bridge

    Directory of Open Access Journals (Sweden)

    Qing Zheng


    Full Text Available Although China has promoted the construction of Chinese Sustainable Ground Transportation (CSGT to guide sustainable development, it may create substantial challenges, such as rapid urban growth and land limitations. This research assessed the effects of the Hangzhou Bay Bridge on impervious surface growth in Cixi County, Ningbo, Zhejiang Province, China. Changes in impervious surfaces were mapped based on Landsat images from 1995, 2002, and 2009 using a combination of multiple endmember spectral mixture analysis (MESMA and landscape metrics. The results indicated that the area and density of impervious surfaces increased significantly during construction of the Hangzhou Bay Bridge (2002–2009. Additionally, the bridge and connected road networks promoted urban development along major roads, resulting in compact growth patterns of impervious surfaces in urbanized regions. Moreover, the Hangzhou Bay Bridge promoted the expansion and densification of impervious surfaces in Hangzhou Bay District, which surrounds the bridge. The bridge also accelerated socioeconomic growth in the area, promoting rapid urban growth in Cixi County between 2002 and 2009. Overall, the Hangzhou Bay Bridge is an important driver of urban growth in Cixi County, and policy suggestions for sustainable urban growth should be adopted in the future.

  6. Modeling of Diversification of Market as a Basis for Sustainable Economic Growth

    Directory of Open Access Journals (Sweden)

    Derunova Elena Anatol’evna


    Full Text Available The article considers the issue of dependence of key macroeconomic indicators on the energy supply price dynamics, especially oil price, relevant to the modern Russian economy. In order to overcome the negative trends related to oil price dynamics, the authors propose to consider the measures on the gradual diversification of the Russian economy as an effective tool of state regulation. To test the hypothesis that diversification contributes to the increase in sustainability of the national economic system, the authors review the simultaneous equations model, the endogenous variables of which include structural values which reflect the structure of national production system. The share of gross value added (hereinafter, GVA generated in the i-th sector in the total GVA and the base GVA index generated in the i-th sector similar to the industry output index sequentially serve as endogenous variables in this study. The test of the hypothesis was carried out in two stages: at the first stage, according to the results of econometric modeling, the indicator of the real effective ruble exchange rate to foreign currencies was chosen as the main exogenous variable; at the second stage, the basic system of equations was evaluated. Econometric calculations have been made for the following types of economic activity (according to the classification of the\tRussian National Classifier of Economic Activities: agriculture, hunting and forestry; mineral extraction; manufacturing; wholesale and retail trade; repairs of motor vehicles, motorcycles, household goods and personal appliances. During the econometric modeling, co-integrated equations for the pairs of indicators under study have been obtained; it has also been concluded that there are significant disparities in the selected economic sectors. The analysis of the obtained data has helped develop a set of measures of state regulation aimed at overcoming the existing disparities

  7. Physiological Functions of Cyclic Electron Transport Around Photosystem I in Sustaining Photosynthesis and Plant Growth. (United States)

    Yamori, Wataru; Shikanai, Toshiharu


    The light reactions in photosynthesis drive both linear and cyclic electron transport around photosystem I (PSI). Linear electron transport generates both ATP and NADPH, whereas PSI cyclic electron transport produces ATP without producing NADPH. PSI cyclic electron transport is thought to be essential for balancing the ATP/NADPH production ratio and for protecting both photosystems from damage caused by stromal overreduction. Two distinct pathways of cyclic electron transport have been proposed in angiosperms: a major pathway that depends on the PROTON GRADIENT REGULATION 5 (PGR5) and PGR5-LIKE PHOTOSYNTHETIC PHENOTYPE 1 (PGRL1) proteins, which are the target site of antimycin A, and a minor pathway mediated by the chloroplast NADH dehydrogenase-like (NDH) complex. Recently, the regulation of PSI cyclic electron transport has been recognized as essential for photosynthesis and plant growth. In this review, we summarize the possible functions and importance of the two pathways of PSI cyclic electron transport.

  8. Sustained Partial Sleep Deprivation: Effects on Immune Modulation and Growth Factors (United States)

    Mullington, Janet M.


    The vulnerability to medical emergencies is greatest in space where there are real limits to the availability or effectiveness of ground based assistance. Moreover, astronaut safety and health maintenance will be of increasing importance as we venture out into space for extended periods of time. It is therefore critical to understand the mechanisms of the regulatory physiology of homeostatic systems (sleep, circadian, neuroendocrine, fluid and nutritional balance) and the key roles played in adaptation. This synergy project has combined aims of the "Human Performance Factors, Sleep and Chronobiology Team"; the "Immunology, Infection and Hematology Team"; and the "Muscle Alterations and Atrophy Team", to broadly address the effects of long term sleep reduction, as is frequently encountered in space exploration, on neuroendocrine, neuroimmune and circulating growth factors. Astronaut sleep is frequently curtailed to averages of between 4- 6.5 hours per night. There is evidence that this amount of sleep is inadequate for maintaining optimal daytime functioning. However, there is a lack of information concerning the effects of chronic sleep restriction, or reduction, on regulatory physiology in general, and there have been no controlled studies of the cumulative effects of chronic sleep reduction on neuroendocrine and neuroimmune parameters. This synergy project represents a pilot study designed to characterize the effects of chronic partial sleep deprivation (PSD) on neuroendocrine, neuroimmune and growth factors. This project draws its subjects from two (of 18) conditions of the larger NSBRI project, "Countermeasures to Neurobehavioral Deficits from Cumulative Partial Sleep Deprivation During Space Flight", one of the projects on the "Human Performance Factors, Sleep and Chronobiology Team ". For the purposes of this study, to investigate the effects of chronic sleep loss on neuroendocrine and neuroimmune function, we have focused on the two extreme sleep conditions

  9. Spastic paraplegia, dysarthria, brachydactyly, and cone shaped epiphyses: confirmation of the Fitzsimmons syndrome

    NARCIS (Netherlands)

    Hennekam, R. C.


    A girl with slowly progressive difficulty in walking, dysarthria, growth retardation, brachydactyly, and cone shaped epiphyses is described. This constellation of symptoms was described in 1987 by Fitzsimmons and Guilbert. It probably represents a rare mendelian disorder of unknown cause

  10. The gompertz function can coherently describe microbial mineralization of growth-sustaining pesticides. (United States)

    Johnsen, Anders R; Binning, Philip J; Aamand, Jens; Badawi, Nora; Rosenbom, Annette E


    Mineralization of (14)C-labeled tracers is a common way of studying the environmental fate of xenobiotics, but it can be difficult to extract relevant kinetic parameters from such experiments since complex kinetic functions or several kinetic functions may be needed to adequately describe large data sets. In this study, we suggest using a two-parameter, sigmoid Gompertz function for parametrizing mineralization curves. The function was applied to a data set of 252 normalized mineralization curves that represented the potential for degradation of the herbicide MCPA in three horizons of an agricultural soil. The Gompertz function fitted most of the normalized curves, and trends in the data set could be visualized by a scatter plot of the two Gompertz parameters (rate constant and time delay). For agricultural topsoil, we also tested the effect of the MCPA concentration on the mineralization kinetics. Reduced initial concentrations lead to shortened lag-phases, probably due to reduced need for bacterial growth. The effect of substrate concentration could be predicted by simply changing the time delay of the Gompertz curves. This delay could to some extent also simulate concentration effects for 2,4-D mineralization in agricultural soil and aquifer sediment and 2,6-dichlorobenzamide mineralization in single-species, mineral medium.

  11. Ecophysiological traits sustaining tree growth and survival under drying climate in the Mediterranean (United States)

    Yakir, D.; Klein, T.; Cohen, S.


    The rate of evolutionary adaptation in long-lived organisms such as forest trees cannot compete with the current and predicted rate of climate change. Tree growth and survival under warming and drying climate, such as predicted for the Mediterranean and other regions, will depend therefore on the existing plasticity of physiological and phenological traits. We examined seven physiological and phenological parameters in Pinus halepensis, a drought resistant Mediterranean tree species, using five ecotypes growing under meso-Mediterranean (MM), thermo-Mediterranean (TM), and semi-arid (SA) climates. The results revealed that both phenotypic plasticity and locally adapted ecotypes contributed, differentially, to the success of this species across a wide range of climatic conditions. While some ecotypes had an inherent xylem resistance to embolism (percent loss of conductivity halepensis performs well under drought conditions it has a sensitive hydraulic system. This was reflected in 50% loss of hydraulic conductivity at relatively high leaf water potential of -3.1 MPa. This, however, was compensated for by a narrow safety margin allowing leaf gas exchange up to leaf water potential of -2.8 MPa. The hydraulic sensitivity also requires fast cavitation reversal, which was indeed observed in the dry season on hourly time-scale: Two cycles of cavitation and reversal observed during morning and afternoon, which were also reflected in a decoupling between sap flow and leaf transpiration. The results indicate newly observed hydraulic capabilities of trees that together with plasticity of other traits facilitate the adjustment to increasingly dry conditions, and the potential of P. halepensis to maintain its current geographical distribution even in face of predicted warming and drying trends.

  12. Engineered cost-effective growth of Co-based nanoflakes as a sustainable water oxidation electrocatalyst (United States)

    Pourreza, M.; Naseri, N.


    Developing low-cost, scalable and reproducible synthesis methods for water oxidation reaction (WOR) catalysts is highly desirable and also challenging in energy, environmental and industrial applications. In this context, electrochemical deposition is known as an easy and cost-effective technique in nanomaterial growth. Herein, cobalt-based nanoflakes were grown on a flexible and commercially available steel mesh substrate by electrodeposition approach with a crystalline structure as a mixture of oxide, hydroxide and oxyhydroxide phases. For the first time, the correlation between electrodeposition parameters, time and current density, and morphological characteristics of the grown nanoflakes (density and aspect ratio based on SEM results) has been derived. According to a comprehensive study of the flakes’ electrocatalytic performance in WOR, the optimized sample fabricated with a moderate electrodeposition current density (7 mA cm‑2) and duration time (2000 s) revealed the highest density (7.6  ×  108 cm‑2) and aspect ratio (7.1) as well as the lowest values for overpotential (OP  =  324 mV) and charge transfer resistance (14 Ω). This designed array of Co-based nanoflakes also showed the lowest value of overpotential for bare cobalt-based WOR electrocatalysts reported yet. High and low values for deposition current density and/or deposition time had a negative effect on the sample surface, leaving some areas without any flakes or with incomplete and inefficient formation of nanoflakes with low densities and aspect ratios. A similar effect was observed for annealed samples in the range of 200–400 °C. Based on recorded overpotentials and extracted surface morphological parameters, a linear and logarithmic behavior in overpotential–flake density dependency was proposed for current density and time controlled systems, respectively.

  13. Dormancy of growth-stunted malignant melanoma: sustainable and smoldering patterns

    Directory of Open Access Journals (Sweden)

    Claudine Piérard-Franchimont


    Full Text Available The presentations of primary and metastatic cutaneous malignant melanoma (CMM are very diverse. Evidence increasingly indicates that single CMM cells spread to distant sites quite early during cancer progression and are soon eliminated before they become clinically detectable. However bulky metastases which appear at a later stage might derive from some of these early neoplastic cells. It seems that local CMM single cell micro-metastases commonly predict sentinel lymph node involvement without overtly reflecting CMM progression to bulky visceral metastases. This study is intended to review the current understanding of the mechanisms underlying two CMM presentations. The first is the long interval, apparently disease-free, with persistent CMM dormancy, which may precede overt metastatic growth. Immunosurveillance may induce dormancy in single CMM cells disseminated in the body by blocking their proliferation cycle. The second is the socalled CMM smoldering phenomenon, which is marked by an alternate progression and regression of CMM locally with metastases that wax and wane for long periods of time over restricted skin areas. These very diverse patterns of CMM progression are likely to be ascribable to a number of biological factors, including the activation of CMM stem cells, and the combined phenotypic heterogeneity and variability in proliferative amplification in CMM cell clusters. Furthermore an adequate stimulation of CMM immune-surveillance and the induction of a specific stromal structure and vascular response are required. In this context, most early CMM tumors are in part controlled by lymphocytemediated responses before they become clinically detectable. However both the role of immune-surveillance and the mechanisms underlying both persistent and smoldering CMM dormancy remain unclear.

  14. Dormancy of growth-stunted malignant melanoma: sustainable and smoldering patterns. (United States)

    Piérard-Franchimont, Claudine; Hermanns-Lê, Trinh; Delvenne, Philippe; Piérard, Gerald E


    The presentations of primary and metastatic cutaneous malignant melanoma (CMM) are very diverse. Evidence increasingly indicates that single CMM cells spread to distant sites quite early during cancer progression and are soon eliminated before they become clinically detectable. However bulky metastases which appear at a later stage might derive from some of these early neoplastic cells. It seems that local CMM single cell micro-metastases commonly predict sentinel lymph node involvement without overtly reflecting CMM progression to bulky visceral metastases. This study is intended to review the current understanding of the mechanisms underlying two CMM presentations. The first is the long interval, apparently disease-free, with persistent CMM dormancy, which may precede overt metastatic growth. Immunosurveillance may induce dormancy in single CMM cells disseminated in the body by blocking their proliferation cycle. The second is the so-called CMM smoldering phenomenon, which is marked by an alternate progression and regression of CMM locally with metastases that wax and wane for long periods of time over restricted skin areas. These very diverse patterns of CMM progression are likely to be ascribable to a number of biological factors, including the activation of CMM stem cells, and the combined phenotypic heterogeneity and variability in proliferative amplification in CMM cell clusters. Furthermore an adequate stimulation of CMM immune-surveillance and the induction of a specific stromal structure and vascular response are required. In this context, most early CMM tumors are in part controlled by lymphocyte-mediated responses before they become clinically detectable. However both the role of immune-surveillance and the mechanisms underlying both persistent and smoldering CMM dormancy remain unclear.

  15. Technological upgrading in global value chains and clusters and their contribution to sustaining economic growth in low and middle income economies

    NARCIS (Netherlands)

    Kaplinsky, R.


    This paper begins with a discussion of the role played by upgrading in the promotion of sustainable growth. Upgrading is discussed in two different contexts, that of industrial clusters and that of global value chains (GVCs). Drawing on global and African experiences, the paper addresses the

  16. Stabilizing Sustainability

    DEFF Research Database (Denmark)

    Reitan Andersen, Kirsti

    The publication of the Brundtland Report in 1987 put the topic of sustainable development on the political and corporate agenda. Defining sustainable development as “a development that meets the needs of the future without compromising the ability of future generations to meet their own needs......” (WCED, 1987, p. 43), the Report also put a positive spin on the issue of sustainability by upholding capitalist beliefs in the possibility of infinite growth in a world of finite resources. While growth has delivered benefits, however, it has done so unequally and unsustainably. This thesis focuses...... on the textile and fashion industry, one of the world’s most polluting industries and an industry to some degree notorious for leading the ‘race to the bottom’ in global labour standards. Despite being faced with increasing demands to practise sustainability, most textile and fashion companies continue to fail...

  17. Long-Term Urban Growth and Land Use Efficiency in Southern Europe: Implications for Sustainable Land Management

    Directory of Open Access Journals (Sweden)

    Marco Zitti


    Full Text Available The present study illustrates a multidimensional analysis of an indicator of urban land use efficiency (per-capita built-up area, LUE in mainland Attica, a Mediterranean urban region, along different expansion waves (1960–2010: compaction and densification in the 1960s, dispersed growth along the coasts and on Athens’ fringe in the 1970s, fringe consolidation in the 1980s, moderate re-polarization and discontinuous expansion in the 1990s and sprawl in remote areas in the 2000s. The non-linear trend in LUE (a continuous increase up to the 1980s and a moderate decrease in 1990 and 2000 preceding the rise observed over the last decade reflects Athens’ expansion waves. A total of 23 indicators were collected by decade for each municipality of the study area with the aim of identifying the drivers of land use efficiency. In 1960, municipalities with low efficiency in the use of land were concentrated on both coastal areas and Athens’ fringe, while in 2010, the lowest efficiency rate was observed in the most remote, rural areas. Typical urban functions (e.g., mixed land uses, multiple-use buildings, vertical profile are the variables most associated with high efficiency in the use of land. Policies for sustainable land management should consider local and regional factors shaping land use efficiency promoting self-contained expansion and more tightly protecting rural and remote land from dispersed urbanization. LUE is a promising indicator reflecting the increased complexity of growth patterns and may anticipate future urban trends.

  18. Flower vs. leaf feeding by Pieris brassicae: glucosinolate-rich flower tissues are preferred and sustain higher growth rate. (United States)

    Smallegange, R C; van Loon, J J A; Blatt, S E; Harvey, J A; Agerbirk, N; Dicke, M


    Interactions between butterflies and caterpillars in the genus Pieris and plants in the family Brassicaceae are among the best explored in the field of insect-plant biology. However, we report here for the first time that Pieris brassicae, commonly assumed to be a typical folivore, actually prefers to feed on flowers of three Brassica nigra genotypes rather than on their leaves. First- and second-instar caterpillars were observed to feed primarily on leaves, whereas late second and early third instars migrated via the small leaves of the flower branches to the flower buds and flowers. Once flower feeding began, no further leaf feeding was observed. We investigated growth rates of caterpillars having access exclusively to either leaves of flowering plants or flowers. In addition, we analyzed glucosinolate concentrations in leaves and flowers. Late-second- and early-third-instar P. brassicae caterpillars moved upward into the inflorescences of B. nigra and fed on buds and flowers until the end of the final (fifth) instar, after which they entered into the wandering stage, leaving the plant in search of a pupation site. Flower feeding sustained a significantly higher growth rate than leaf feeding. Flowers contained levels of glucosinolates up to five times higher than those of leaves. Five glucosinolates were identified: the aliphatic sinigrin, the aromatic phenylethylglucosinolate, and three indole glucosinolates: glucobrassicin, 4-methoxyglucobrassicin, and 4-hydroxyglucobrassicin. Tissue type and genotype were the most important factors affecting levels of identified glucosinolates. Sinigrin was by far the most abundant compound in all three genotypes. Sinigrin, 4-hydroxyglucobrassicin, and phenylethylglucosinolate were present at significantly higher levels in flowers than in leaves. In response to caterpillar feeding, sinigrin levels in both leaves and flowers were significantly higher than in undamaged plants, whereas 4-hydroxyglucobrassicin leaf levels were

  19. Nucleation and condensational growth to CCN sizes during a sustained pristine biogenic SOA event in a forested mountain valley

    Directory of Open Access Journals (Sweden)

    J. R. Pierce


    Full Text Available The Whistler Aerosol and Cloud Study (WACS 2010, included intensive measurements of trace gases and particles at two sites on Whistler Mountain. Between 6–11 July 2010 there was a sustained high-pressure system over the region with cloud-free conditions and the highest temperatures of the study. During this period, the organic aerosol concentrations rose from <1 μg m−3 to ∼6 μg m−3. Precursor gas and aerosol composition measurements show that these organics were almost entirely of secondary biogenic nature. Throughout 6–11 July, the anthropogenic influence was minimal with sulfate concentrations <0.2 μg m−3 and SO2 mixing ratios ≈ 0.05–0.1 ppbv. Thus, this case provides excellent conditions to probe the role of biogenic secondary organic aerosol in aerosol microphysics. Although SO2 mixing ratios were relatively low, box-model simulations show that nucleation and growth may be modeled accurately if Jnuc = 3 × 10−7[H2SO4] and the organics are treated as effectively non-volatile. Due to the low condensation sink and the fast condensation rate of organics, the nucleated particles grew rapidly (2–5 nm h−1 with a 10–25% probability of growing to CCN sizes (100 nm in the first two days as opposed to being scavenged by coagulation with larger particles. The nucleated particles were observed to grow to ∼200 nm after three days. Comparisons of size-distribution with CCN data show that particle hygroscopicity (κ was ∼0.1 for particles larger 150 nm, but for smaller particles near 100 nm the κ value decreased near midway through the period from 0.17 to less than 0.06. In this environment of little anthropogenic influence and low SO2, the rapid growth rates of the regionally nucleated particles – due to condensation of biogenic SOA – results in an unusually high efficiency of conversion of

  20. Technology and sustainability

    NARCIS (Netherlands)

    Kroeze, C.; Boersema, J.J.; Tellegen, E.; Cremers, A.


    In ten essays, this book addresses a broad range of issues related to the interplay of sustainability and technology. How do population growth and technology relate to sustainable development? Can globalization be reconciled with sustainable development? Is sustainability a subjective or an

  1. On the Dual of the Solvency Cone


    Löhne, Andreas; Rudloff, Birgit


    A solvency cone is a polyhedral convex cone which is used in Mathematical Finance to model proportional transaction costs. It consists of those portfolios which can be traded into nonnegative positions. In this note, we provide a characterization of its dual cone in terms of extreme directions and discuss some consequences, among them: (i) an algorithm to construct extreme directions of the dual cone when a corresponding "contribution scheme" is given; (ii) estimates for the number of extreme...

  2. Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia. (United States)

    Kumagai, Motoyuki; Marui, Akira; Tabata, Yasuhiko; Takeda, Takahide; Yamamoto, Masaya; Yonezawa, Atsushi; Tanaka, Shiro; Yanagi, Shigeki; Ito-Ihara, Toshiko; Ikeda, Takafumi; Murayama, Toshinori; Teramukai, Satoshi; Katsura, Toshiya; Matsubara, Kazuo; Kawakami, Koji; Yokode, Masayuki; Shimizu, Akira; Sakata, Ryuzo


    As a form of therapeutic angiogenesis, we sought to investigate the safety and efficacy of a sustained-release system of basic fibroblast growth factor (bFGF) using biodegradable gelatin hydrogel in patients with critical limb ischemia (CLI). We conducted a phase I-IIa study that analyzed 10 CLI patients following a 200-μg intramuscular injection of bFGF-incorporated gelatin hydrogel microspheres into the ischemic limb. Primary endpoints were safety and transcutaneous oxygen pressure (TcO2) at 4 and 24 weeks after treatment. During the follow-up, there was no death or serious procedure-related adverse event. After 24 weeks, TcO2 (28.4 ± 8.4 vs. 46.2 ± 13.0 mmHg for pretreatment vs after 24 weeks, p < 0.01) showed significant improvement. Regarding secondary endpoints, the distance walked in 6 min (255 ± 105 vs. 318 ± 127 m, p = 0.02), the Rutherford classification (4.4 ± 0.5 vs. 3.1 ± 1.4, p = 0.02), the rest pain scale (1.7 ± 1.0 vs. 1.2 ± 1.3, p = 0.03), and the cyanotic scale (2.0 ± 1.1 vs. 0.9 ± 0.9, p < 0.01) also showed improvement. The blood levels of bFGF were within the normal range in all patients. A subanalysis of patients with arteriosclerosis obliterans (n = 7) or thromboangiitis obliterans (Buerger's disease) (n = 3) revealed that TcO2 had significantly improved in both subgroups. TcO2 did not differ between patients with or without chronic kidney disease. The sustained release of bFGF from biodegradable gelatin hydrogel may offer a safe and effective form of angiogenesis for patients with CLI.

  3. Seawave Slot-Cone Generator

    DEFF Research Database (Denmark)

    Vicinanza, Diego; Margheritini, Lucia; Contestabile, Pasquale


    This paper discusses a new type of Wave Energy Converter (WEC) named Seawave Slot-Cone Generator (SSG). The SSG is a WEC of the overtopping type. The structure consists of a number of reservoirs one on the top of each others above the mean water level in which the water of incoming waves is store...

  4. Intrinsic volumes of symmetric cones


    Amelunxen, Dennis; Bürgisser, Peter


    We compute the intrinsic volumes of the cone of positive semidefinite matrices over the real numbers, over the complex numbers, and over the quaternions, in terms of integrals related to Mehta's integral. Several applications for the probabilistic analysis of semidefinite programming are given.

  5. Technologies for sustainable growth

    Energy Technology Data Exchange (ETDEWEB)


    Climate change is real. And it's happening much faster than was predicted just a few years ago. The good news is that there is a good chance that we really can do something about the problem. And this is in a way where we don't need to compromise the well-being of our global economy. All it takes is to follow a Bright Green strategy where we get the most out of the energy we produce and where we deploy the clean energy technologies we already know can work. Doing so would deliver the affordability, stability and confidence our economies need, as well as help solve the climate crisis. Although our reliance on fossil fuels has created global warming, we now have the opportunity and obligation to begin a transformation towards a robust clean energy economy. This is the opportunity of our generation. To begin a transformation to an economy that is robust without causing environmental harm. But there won't be a single, 'silver bullet' solution. We will need to address energy production, carbon mitigation and efficient consumption of energy. A new approach is needed that both avoids dangerous climate change and is advantageous for the economy - a Bright Green strategy with a strong focus on deploying and investing in climate friendly technologies. Denmark has done this for several decades and we are a clear example that it is possible to both grow our economy and at the same time take care of the environment and especially the global environment. This book tells the Bright Green story of Denmark, and presents a wide range of technologies and solutions that can help pave the way towards a more climate friendly future. (au)

  6. Livestock biodiversity and sustainability

    NARCIS (Netherlands)

    Hoffmann, I.


    Sustainable development equally includes environmental protection including biodiversity, economic growth and social equity, both within and between generations. The paper first reviews different aspects related to the sustainable use of livestock biodiversity and property regimes that influence

  7. Sustainable syntrophic growth of Dehalococcoides ethenogenes strain 195 with Desulfovibrio vulgaris Hildenborough and Methanobacterium congolense: Global transcriptomic and proteomic analyses

    Energy Technology Data Exchange (ETDEWEB)

    Men, Y.; Feil, H.; VerBerkmoes, N.C.; Shah, M.B.; Johnson, D.R.; Lee, P.K.H; West, K.A.; Zinder, S.H.; Andersen, G.L.; Alvarez-Cohen, L.


    Dehalococcoides ethenogenes strain 195 (DE195) was grown in a sustainable syntrophic association with Desulfovibrio vulgaris Hildenborough (DVH) as a co-culture, as well as with DVH and the hydrogenotrophic methanogen Methanobacterium congolense (MC) as a tri-culture using lactate as the sole energy and carbon source. In the co- and tri-cultures, maximum dechlorination rates of DE195 were enhanced by approximately three times (11.0±0.01 lmol per day for the co-culture and 10.1±0.3 lmol per day for the tri-culture) compared with DE195 grown alone (3.8±0.1 lmol per day). Cell yield of DE195 was enhanced in the co-culture (9.0±0.5 x 107 cells per lmol Cl{sup -} released, compared with 6.8±0.9x 107 cells per lmol Cl{sup -} released for the pure culture), whereas no further enhancement was observed in the tri-culture (7.3±1.8x 107 cells per lmol Cl{sup -} released). The transcriptome of DE195 grown in the co-culture was analyzed using a whole-genome microarray targeting DE195, which detected 102 significantly up- or down-regulated genes compared with DE195 grown in isolation, whereas no significant transcriptomic difference was observed between co- and tri-cultures. Proteomic analysis showed that 120 proteins were differentially expressed in the co-culture compared with DE195 grown in isolation. Physiological, transcriptomic and proteomic results indicate that the robust growth of DE195 in co- and tri-cultures is because of the advantages associated with the capabilities of DVH to ferment lactate to provide H2 and acetate for growth, along with potential benefits from proton translocation, cobalamin-salvaging and amino acid biosynthesis, whereas MC in the tri-culture provided no significant additional benefits beyond those of DVH.


    Directory of Open Access Journals (Sweden)

    N. Ya. Kazhuro


    Full Text Available When the global community entered in the XXI century world emerging economy is more clearly considered as post-industrial, where a leading sector of the economy in the GDP production is not agriculture and not even industry but services. The main productive resource in such circumstances is not natural and productive capital but human capital, which is represented by storage of knowledge and skills accumulated by a person in the process of training and previous employment. Value of this capital is directly dependent on the level of education both general and professional. Human intellect becomes a main factor of production and professional. If the level is higher it means that such person can perform more valuable types of work for expand wealth of the country and it is transformed into intellectual capital. Consequently, a special market is formed that is a market of intellectual capital. An offer in this market is represented by labor with a high level of intellectuality and innovativeness and it has, in its turn, high market value. Well-handled components of human capital contribute to scientific-technical and social progress of the society, its sustainable economic development as the main types of final products unlike with previous stages of development are information and knowledge and the main factor of economic growth is productivity of mental labor workers. It is human capital that is one of the main factors ensuring transition to V and VI technological paradigms under current conditions. These paradigms are underlying a solid foundation for formation of new intellectual and information society. New knowledge and information technologies are making a breakthrough not only in the direct production of commodities but in the non-manufacturing sector as well (education, health, trade, finance etc..

  9. Ethnography of a Sustainable Agriculture Program: A Case Study of a Social Movement's Inception and Growth on a University Campus (United States)

    Triana, Benjamin


    This ethnography documents how the message of sustainability was interpreted and communicated through a sustainable agricultural (SAG) program at an American higher education institution. The ethnography documents the evolution of the program as the program tackled obstacles and accomplished its goals during the initial phases of the program's…

  10. Diameter growth rates in tropical dry forests: contributions to the sustainable management of forests in the Bolivian Cerrado biogeographical province

    NARCIS (Netherlands)

    Lopez, L.; Villalba, R.; Peña-Claros, M.


    Growth ring variations were used to provide the rates in diameter growth for seven tree species in the Bolivian Cerrado biogeographical province. Ten to 50 trees were measured per species. Ring width measurements provided accurate data on the rates of tree growth. Variations in growth rates were

  11. Growth - Sustainable aquafeeds for marine finfish: Effects of vegetable oil replacement feeds containing novel microalgal and fungal oils on growth performance of juvenile sablefish (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The concomitant replacement of fish meal and fish oil in carnivorous marine fish feeds by more sustainable terrestrial alternatives is problematic due to the limited...

  12. Light-cone quantization of quantum chromodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, S.J. (Stanford Linear Accelerator Center, Menlo Park, CA (USA)); Pauli, H.C. (Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany, F.R.))


    We discuss the light-cone quantization of gauge theories from two perspectives: as a calculational tool for representing hadrons as QCD bound-states of relativistic quarks and gluons, and also as a novel method for simulating quantum field theory on a computer. The light-cone Fock state expansion of wavefunctions at fixed light cone time provides a precise definition of the parton model and a general calculus for hadronic matrix elements. We present several new applications of light-cone Fock methods, including calculations of exclusive weak decays of heavy hadrons, and intrinsic heavy-quark contributions to structure functions. A general nonperturbative method for numerically solving quantum field theories, discretized light-cone quantization,'' is outlined and applied to several gauge theories, including QCD in one space and one time dimension, and quantum electrodynamics in physical space-time at large coupling strength. The DLCQ method is invariant under the large class of light-cone Lorentz transformations, and it can be formulated such at ultraviolet regularization is independent of the momentum space discretization. Both the bound-state spectrum and the corresponding relativistic light-cone wavefunctions can be obtained by matrix diagonalization and related techniques. We also discuss the construction of the light-cone Fock basis, the structure of the light-cone vacuum, and outline the renormalization techniques required for solving gauge theories within the light-cone Hamiltonian formalism.

  13. Towards the development of an integrated sustainability and resilience benefits assessment framework of urban green growth interventions

    NARCIS (Netherlands)

    S. Grafakos (Stelios); A. Gianoli (Alberto); Tsatsou, A. (Alexandra)


    textabstractConsidering the current emerging demographic, urbanization and climatic trends, integrating sustainability and resilience principles into urban development becomes a key priority for decision-makers worldwide. Local and national governments, project developers and other urban

  14. Do private sustainability standards contribute to income growth and poverty alleviation? A comparison of different coffee certification schemes in Ethiopia

    NARCIS (Netherlands)

    Mitiku, Fikadu; Mey, de Yann; Nyssen, Jan; Maertens, Miet


    Private sustainability standards are increasingly important in food trade with developing countries, but the implications for smallholder farmers are still poorly understood. We analyze the implications of different coffee certification schemes in Ethiopia using cross-sectional survey data, and

  15. Analysis of the Sustainable Growth Indicator in the Area of Climate Change from the Point of View of Europe 2020 Strategy Performance

    Directory of Open Access Journals (Sweden)

    Dagmar Blatná


    Full Text Available The objective of this paper is to present the results of an analysis of the indicator Greenhouse gas emissions (GGE. The GGE is one of the headline indicators tracked under the EU’s main socioeconomic strategy until the year 2020 – the EUROPE 2020 strategy for smart, sustainable and inclusive growth. In the area of sustainable growth, the Resource-efficient Europe initiative was established. For 2020, the EU has made a unilateral commitment to reduce overall greenhouse gas emissions from its 28 member states by 20 % compared to 1990 levels. The GGE indicator shows total man-made emissions of the so-called Kyoto basket of greenhouse gases. It presents annual total emissions in relation to those observed in 1990. The aggregate greenhouse gas emissions are expressed in units of CO2 equivalent. The development of the GGE indicator in the EU and in the Czech Republic from 2000 to 2014 from the point of view of the ability to achieve the Strategy objectives is analyzed. In terms of the level of the analyzed indicator, the set of the EU countries can be divided into two significantly different groups – the euro area and the non-euro area; or into groups by the year of their joining the EU. Analyses of the dependency between the growth of GGE and the GDP growth for both the set of the 28 EU countries and the Czech Republic are presented as well.

  16. Geomorphometric variability of "monogenetic" volcanic cones: Evidence from Mauna Kea, Lanzarote and experimental cones (United States)

    Kervyn, M.; Ernst, G. G. J.; Carracedo, J.-C.; Jacobs, P.


    Volcanic cones are the most common volcanic constructs on Earth. Their shape can be quantified using two morphometric ratios: the crater/cone base ratio (W cr/W co) and the cone height/width ratio (H co/W co). The average values for these ratios obtained over entire cone fields have been explained by the repose angle of loose granular material (i.e. scoria) controlling cone slopes. The observed variability in these ratios between individual cones has been attributed to the effect of erosional processes or contrasting eruptive conditions on cone morphometry. Using a GIS-based approach, high spatial resolution Digital Elevation Models and airphotos, two new geomorphometry datasets for cone fields at Mauna Kea (Hawaii, USA) and Lanzarote (Canary Islands, Spain) are extracted and analyzed here. The key observation in these datasets is the great variability in morphometric ratios, even for simple-shape and well-preserved cones. Simple analog experiments are presented to analyze factors influencing the morphometric ratios. The formation of a crater is simulated within an analog cone (i.e. a sand pile) by opening a drainage conduit at the cone base. Results from experiments show that variability in the morphometric ratios can be attributed to variations in the width, height and horizontal offset of the drainage point relative to the cone symmetry axis, to the dip of the underlying slope or to the influence of a small proportion of fine cohesive material. GIS analysis and analog experiments, together with specific examples of cones documented in the field, suggest that the morphometric ratios for well-preserved volcanic cones are controlled by a combination of 1) the intrinsic cone material properties, 2) time-dependent eruption conditions, 3) the local setting, and 4) the method used to estimate the cone height. Implications for interpreting cone morphometry solely as either an age or as an eruption condition indicator are highlighted.

  17. Disinfection of artificially contaminated Resilon cones with chlorhexidine and sodium hypochlorite at different time exposures. (United States)

    Dumani, Aysin; Yoldas, Oguz; Isci, A Sehnaz; Köksal, Fatih; Kayar, Begüm; Polat, Esra


    The aim of this study was to evaluate the efficiency of chlorhexidine (CHX) and sodium hypochlorite (NaOCl) solutions on Resilon cones that were artificially contaminated with microbial samples of Enterococcus faecalis or Candida albicans at various concentrations and time exposures. Resilon cones artificially contaminated with E faecalis or C albicans were left in contact with 1% NaOCl, 5% NaOCl, and 2% CHX disinfecting solutions for 1 and 5 minutes. The cones were then individually transferred to the test tubes, which contained 10 mL of thioglycollate media, and were incubated at 37 degrees C for 7 days. The antimicrobial activities of tested agents were determined by microbial growth. All of the Resilon cones contaminated with E faecalis or C albicans could be disinfected with 1% and 5% NaOCl for 1 and 5 minutes and with 2% CHX for 5 minutes. Three of 7 Resilon cones contaminated with E faecalis and 1 of 7 Resilon cones contaminated with C albicans could not be disinfected with 2% CHX at 1 minute of treatment. In conclusion, these results demonstrated that 1% and 5% NaOCl solutions are effective agents for disinfecting Resilon cones in 1- or 5-minute treatments. Two percent CHX was only effective after 5 minutes of treatment.

  18. Analysing Italian Regional Patterns in Green Economy and Climate Change. Can Italy Leverage on Europe 2020 Strategy to Face Sustainable Growth Challenges ?

    Directory of Open Access Journals (Sweden)

    Francesco BONSINETTO


    Full Text Available European cities and regions are facing the crucial challenge of greening their economy towards more sustainable patterns. Politicians and policy-makers should promote new policies for sustainable growth including renewables, greenhouse gas emissions, energy efficiency and biodiversity. All of these aspects can be considered as a boost for local and regional economy. In this regard, European countries and regions can benefit from the Europe 2020 Strategy which is defined as Europe’s blueprint for a smart, sustainable and inclusive future, providing a ten year roadmap for growth and jobs. EU2020S was designed as a European exit strategy from the global economic and financial crisis in view of new European economic governance. This study discusses the above issues regarding Italy and intends to provide some answers on the perspectives of the new EU2020S. It draws from a research project supported by ESPON, the S.I.E.S.T.A. Project, focused on the territorial dimension of the EU2020S. Therefore, this paper aims at analyzing Italian regional patterns on climate change, green economy and energy within the context of EU2020S and at providing policy recommendations for better achieving the goals of the Strategy.


    Directory of Open Access Journals (Sweden)

    Marius Eremia VLAICU POPA


    Full Text Available In the context of what is implemented through dualism "ecosystem-efficient", sustainable development involves the care of the human potential of the present situation and the future of its natural resources, energy, materials and information. As an effect of responsibility for future generations, the efficient use of resources requires, at the same time, the operation of a sustainable economy, by diversification and development of the labour market in order to meet present and future demands of human society. At local and regional level, through the closing of mines and large enterprises, with an effect in restructuring the economic sector and employment, development strategies and rehabilitation of the affected industrial areas as a common principle approach, analyzing the problems, defining the objectives and policies, identifying actions to attack problems and provide for mechanisms that will enable the progress control. In this paper it is presented the concept of sustainable development as imperative for economic growth, diversification and development of the labour market, being dealt the representative criteria and principles of sustainable development strategy of any company. Are defined the components and objectives of a strategy for local and regional development of industrial areas affected by the restructuring.

  20. Topology of soft cone metric spaces (United States)

    Altintas, Ismet; Simsek, Dagistan; Taskopru, Kemal


    In Simsek's paper it was introduced a concept of soft cone metric space via soft elements and some fixed point theorems in soft cone metric space were provided. In this work, we examine topological structures such as open ball, soft neighbourhood and soft open set in soft metric spaces and their some properties, and prove that every soft cone metric space under some condition is a soft topological space according to elementary operations on soft sets.

  1. Programming Retinal Stem Cells into Cone Photoreceptors (United States)


    to program human stem cells directly into cones. Using RNA -seq, we identified several genes that are upregulated in advance of the earliest...reverse vision loss. 15. SUBJECT TERMS Cone photoreceptor, retina, retinal stem cell, Otx2, Onecut1, Blimp1, RNA -seq., transcription factors, and...sequential activation of OTX2, BLIMP1, and ONECUT1 are sufficient to program hES cell-derived retinal stem cells into transplant- competent cones

  2. G-weak contraction in ordered cone rectangular metric spaces. (United States)

    Malhotra, S K; Sharma, J B; Shukla, Satish


    We prove some common fixed-point theorems for the ordered g-weak contractions in cone rectangular metric spaces without assuming the normality of cone. Our results generalize some recent results from cone metric and cone rectangular metric spaces into ordered cone rectangular metric spaces. Examples are provided which illustrate the results.

  3. g-Weak Contraction in Ordered Cone Rectangular Metric Spaces

    Directory of Open Access Journals (Sweden)

    S. K. Malhotra


    Full Text Available We prove some common fixed-point theorems for the ordered g-weak contractions in cone rectangular metric spaces without assuming the normality of cone. Our results generalize some recent results from cone metric and cone rectangular metric spaces into ordered cone rectangular metric spaces. Examples are provided which illustrate the results.

  4. Light-cones, almost light-cones and almost-complex light-cones (United States)

    Newman, Ezra T.


    We point out (and then apply to a general situation) an unusual relationship among a variety of null geodesic congruences; (a) the generators of ordinary light-cones and (b) certain (related) shear-free but twisting congruences in Minkowski space-time as well as (c) asymptotically shear-free null geodesic congruences that exist in the neighborhood of Penrose's I^{ +} in Einstein or Einstein-Maxwell asymptotically flat-space-times. We refer to these geodesic congruences respectively as: Lignt-Cones (LCs), as "Almost-Complex"-Light-Cones (ACLCs), [though they are real they resemble complex light-cones in complex Minkowski space] and finally to a family of congruences in asymptotically flat-spaces as ` Almost Light-Cones' (ALC). The two essential points of resemblance among the three families are: (1) they are all either shear-free or asymptotically shear-free and (2) in each family the individual members of the family can be labeled by the points in a real or complex four-dimensional manifold. As an example, the Minkowski space LCs are labeled by the (real) coordinate value of their apex. In the case of (ACLCs) (complex coordinate values), the congruences will have non-vanishing twist whose magnitude is determined by the imaginary part of the complex coordinate values. In studies of gravitational radiation, Bondi-type of null surfaces and their associated Bondi coordinates have been almost exclusively used for calculations. It turns out that some surprising relations arise if, instead of the Bondi coordinates, one uses ALCs and their associated coordinate systems in the analysis of the Einstein-Maxwell equations in the neighborhood of I+. More explicitly and surprisingly, the asymptotic Bianchi Identities (arising directly from the Einstein equations), expressed in the coordinates of the ALCs, turn directly into many of the standard definitions and equations and relations of classical mechanics coupled with Maxwell's equations. These results extend and generalize the

  5. Vacuum Compatible Percussive Dynamic Cone Penetrometer Project (United States)

    National Aeronautics and Space Administration — Honeybee Robotics proposes to develop a vacuum compatible percussive dynamic cone penetrometer (PDCP), for establishing soil bin characteristics, with the ultimate...

  6. Reducing dislocation density in GaN films using a cone-shaped patterned sapphire substrate (United States)

    Shin, Hui-Youn; Kwon, S. K.; Chang, Y. I.; Cho, M. J.; Park, K. H.


    The threading dislocation (TD) density in GaN films grown directly on flat sapphire substrates is typically >10 10/cm 2, which can deteriorate the properties of GaN-based LEDs significantly. This paper reports an approach to reducing the TD density in a GaN layer using a variety of patterned sapphire substrates (PSS). A cone-shaped PSS produced by metal organic chemical vapor deposition (MOVCD) was used for GaN deposition. Three types of GaN specimens were prepared at the initial nucleation stage, middle growth stage and final growth stage. The TDs generated on the cone-shaped PSS were analyzed by transmission electron microscopy (TEM) and a strain mapping simulation using HRTEM images, which evaluated the residual strain distribution. A large number of TDs were generated and the residual strain by the lattice distortions remained above the top of the cone-shaped regions. However, no TDs and residual strain were observed at the slope of the cone-shaped regions. This might be due to the formation of a GaN layer by lateral overgrowth at the slope of the cone-shaped regions, resulting in less lattice mismatch and incoherency between the GaN and sapphire. In conclusion, the TD density in the GaN layer could be reduced significantly, approximately 10 7/cm 2, using the cone-shaped PSS.

  7. Ionic emission from Taylor cones (United States)

    Castro Reina, Sergio

    Electrified Taylor cones have been seen as an efficient way to generate thrust for space propulsion. Especially the pure ionic regime (PIR) combines a very high specific impulse (thrust per unit mass) and efficiency, which is very important to reduce fuel transportation costs. The PIR has been primarily based on electrosprays of liquid metals [Swatik and Hendricks 1968, Swatik 1969]. However, emissions dominated by or containing exclusively ions have also been observed from nonmetallic purely ionic substances, initially sulfuric acid [Perel et al. 1969], and more recently room temperature molten salts referred to as ionic liquids (ILs) [Romero-Sanz et al. 2003]. The recent use of the liquid metal ion source (LMIS) with ILs, becoming this "new" source to be known as ionic liquid ion source (ILIS) [Lozano and Martinez-Sanchez 2005], has shown important differences on the emission from Taylor cones with the traditional hollow capillary. This new source seems to be more flexible than the capillary [Paulo, Sergio, carlos], although its low emission level (low thrust) is an important drawback from the space propulsion point of view. Throughout the thesis I have studied some aspects of the ionic emission from ionic liquid Taylor cones and the influence of the properties of the liquids and the characteristic of source on the emission. I have unraveled the reason why ILIS emits such low currents (˜200 nA) and found a way to solve this problem increasing the current up to capillary levels (˜1000 nA) [Castro and Fernandez de la Mora 2009]. I have also tried to reduce ion evaporation while reducing the emitted droplet size in order to increase the thrust generated while keeping the efficiency relatively high and I have measured the energy of evaporation of several cations composing ionic liquids, mandatory step to understand ionic evaporation.

  8. A nanomedicine approach to effectively inhibit contracture during bladder acellular matrix allograft-induced bladder regeneration by sustained delivery of vascular endothelial growth factor. (United States)

    Xiong, Qianwei; Lin, Houwei; Hua, Xiaolin; Liu, Li; Sun, Ping; Zhao, Zhen; Shen, Xiaowei; Cui, Daxiang; Xu, Maosheng; Chen, Fang; Geng, Hongquan


    Macroscopic evidence of contracture has been identified as a major issue during the regeneration process. We hypothesize that lack of angiogenesis is the primary cause of contracture and explore a nanomedicine approach to achieve sustained release of vascular endothelial growth factor (VEGF) to stimulate angiogenesis. We evaluate the efficacy of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) for long-term (3 months) sustained release of VEGF in bladder acellular matrix allografts (BAMA) in a swine model. We anticipate that the sustained release of VEGF could stimulate angiogenesis along the regeneration process and thereby inhibit contracture. Bladder was replaced with BAMA (5×5 cm), modified with PLGA NPs encapsulated with VEGF in a pig model. The time points chosen for sampling were 1, 2, 4, and 12 weeks. The regenerated areas were then measured to obtain the contracture rate, and the extent of revascularization was calculated using histological and morphological features. In the control group of animals, the bladder was replaced with only BAMA. The in vivo release of VEGF was evident for ∼3 months, achieving the goal of long-acting sustained release, and successfully promoted the regeneration of blood vessels and smooth muscle fibers. In addition, less collagen deposition was observed in the experimental group compared with control. Most importantly, the inhibition of contracture was highly significant, and the ultimate contracture rate decreased by ∼57% in the experimental group compared with control. In isolated strips analysis, there were no significant differences between BAMA-regenerated (either VEGF added or not) and autogenous bladder. BAMA modified with VEGF-loaded PLGA-NPs can sustainably release VEGF in vivo (>3 months) to stimulate angiogenesis leading to the inhibition of contracture. This is the first study to report a viable nanomedicine-based strategy to overcome contracture during bladder regeneration induced by BAMA. Furthermore

  9. Sustainability of the effects of medicinal iron and iron rich food supplementation on haemoglobin, intelligence quotient and growth of school aged girls

    Directory of Open Access Journals (Sweden)

    Monika Jain


    Full Text Available Anaemia in school aged girls is an important but neglected issue. Since iron supplementation programmes have had little reported success in reducing anaemia, interest is turning to food based approaches that have higher potential for achieving far reaching benefits. The purpose of the study was to observe sustainability of the effect of iron and food supplementation on haemoglobin (Hb, intelligence quotient (IQ and growth of the subjects. At baseline, estimation of haemoglobin (Hb, red cell indices, serum iron, total iron binding capacity, serum transferrin saturation and serum ferritin was done. IQ, weight and height were measured using standard procedures. Anaemic subjectswere divided into three groups, viz., (i twice weekly supplementation of iron folic acid syrup (53 mg iron/week; (ii daily supplementation of 4 niger seed and defatted soyaflour biscuits plus 2 lemons (45 mg iron/week and (iii control. Non anaemic group(NAC was not intervened. Endline data was collected after 120 days. Follow up for Hb, IQ, weight and height was done 4 months after cessation of supplementation. The prevalence of anaemia was 77% in the study population; 46% subjects had mild anaemia and 32% had moderate anaemia. Iron status was lower in anaemic subjects (p<0.001.Iron supplementation was more effective in raising Hb and building iron stores than iron rich food supplementation. Iron supplementation improved IQ but did not bring about catch up of anaemics to non anaemics. Iron rich food supplementation was better than medicinal iron in promoting growth in anaemic girls. The impact of iron rich food supplementation on Hb, IQ and growth sustained for 4 months while that of medicinal iron did not. Effects of food supplementation are sustainable for 4 months, therefore, this strategy holds more potential to control anaemia, in school aged girls.

  10. Projecting Future Urbanization with Prescott College's Spatial Growth Model to Promote Environmental Sustainability and Smart Growth, A Case Study in Atlanta, Georgia (United States)

    Estes, Maurice G., Jr.; Crosson, William; Limaye, Ashutosh; Johnson, Hoyt; Quattrochi, Dale; Lapenta, William; Khan, Maudood


    Planning is an integral element of good management and necessary to anticipate events not merely respond to them. Projecting the quantity and spatial distribution of urban growth is essential to effectively plan for the delivery of city services and to evaluate potential environmental impacts. The major drivers of growth in large urban areas are increasing population, employment opportunities, and quality of life attractors such as a favorable climate and recreation opportunities. The spatial distribution of urban growth is dictated by the amount and location of developable land, topography, energy and water resources, transportation network, climate change, and the existing land use configuration. The Atlanta region is growing very rapidly both in population and the consumption of forestland or low-density residential development. Air pollution and water availability are significant ongoing environmental issues. The Prescott Spatial Growth Model (SGM) was used to make growth projections for the metropolitan Atlanta region to 2010,2020 and 2030 and results used for environmental assessment in both business as usual and smart growth scenarios. The Prescott SGM is a tool that uses an ESRI ArcView extension and can be applied at the parcel level or more coarse spatial scales and can accommodate a wide range of user inputs to develop any number of growth rules each of which can be weighted depending on growth assumptions. These projections were used in conjunction with meteorological and air quality models to evaluate future environmental impacts. This presentation will focus on the application of the SGM to the 13-County Atlanta Regional Commission planning jurisdiction as a case study. The SGM will be described, including how rule sets are developed and the decision process for allocation of future development to available land use categories. Data inputs required to effectively run the model will be discussed. Spatial growth projections for ten, twenty, and thirty

  11. G20 Priorities and Decisions under Turkey’s 2015 Presidency: Implementation, Inclusiveness and Investment for Strong, Sustainable and Balanced Growth

    Directory of Open Access Journals (Sweden)

    Marina Larionova


    Full Text Available Turkey held the presidency of the G20 (Group of 20 from December 2014 to November 2015. During this period geopolitical tensions started to spread beyond the borders of the regions involved. Turkey went through a challenging time, with a slowing economy, two elections in 2015, revived political confrontations, two million refugees and frustrations in securing its borders and handling terrorism. Turkey defined three priorities for its presidency: inclusiveness, implementation and investment for growth. To combat inequality and ensure inclusive growth, it aimed to address the issues of small and medium-sized enterprises, such as access to finance, skills and global value chains, employment for youth and women, and support to the development of low-income countries. Inclusiveness was also explicit in G20 engagement with social partners. Implementation was emphasized, particularly related to the imperative to deliver on the G20 members’ commitments regarding growth strategies made at the 2014 Brisbane Summit. This article assesses the G20’s performance under the Turkey presidency within a functional paradigm focusing on the three main objectives of plurilateral summitry institutions: strengthening capacity for political leadership to launch new ideas and overcome deadlocks, reconciling domestic and international pressures, and consolidating collective management. To attain those objectives, institutions are expected to demonstrate leadership, solidarity, sustainability, acceptability, consistency and continuity. Efficiency is perceived as G20 performance on a combination of the criteria. Given the G20’s ultimate mission to achieve strong, sustainable, balanced and inclusive growth, all the issues on Turkey’s G20 agenda were grouped according to these four growth pillars. G20 performance on each of the issue areas was assessed on six criteria using a three-point scale: high (1, medium (0 and low (−1 degree of performance. The overall

  12. Background information for the SER Energy Agreement for Sustainable Growth calculations. Sectors Industry, Agriculture and Horticulture; Achtergronddocument bij doorrekening Energieakkoord. Sectoren industrie en land- en tuinbouw

    Energy Technology Data Exchange (ETDEWEB)

    Wetzels, W. [ECN Beleidsstudies, Petten (Netherlands)


    On September 4, 2013, representatives of employers' associations, trade union federations, environmental organizations, the Dutch government and civil society have signed an Energy Agreement for Sustainable Growth. ECN and PBL have been asked to evaluate this agreement. This report gives background information on the evaluation of the measures aimed at improving energy efficiency in industry and agriculture [Dutch] Op 4 september 2013 is het 'Energieakkoord voor duurzame groei' getekend. ECN en PBL zijn gevraagd het akkoord te beoordelen en door te rekenen. Dit rapport dient als achtergronddocument bij de doorrekening van de maatregelen gericht op energiebesparing in de industrie en land- en tuinbouw.

  13. Implications of late-in-life density-dependent growth for fishery size-at-entry leading to maximum sustainable yield

    DEFF Research Database (Denmark)

    van Gemert, Rob; Andersen, Ken Haste


    Currently applied fisheries models and stock assessments rely on the assumption that density-dependent regulation only affects processes early in life, as described by stock–recruitment relationships. However, many fish stocks also experience density-dependent processes late in life......, such as density-dependent adult growth. Theoretical studies have found that, for stocks which experience strong late-in-life density dependence, maximum sustainable yield (MSY) is obtained with a small fishery size-at-entry that also targets juveniles. This goes against common fisheries advice, which dictates...... that primarily adults should be fished. This study aims to examine whether the strength of density-dependent growth in actual fish stocks is sufficiently strong to reduce optimal fishery size-at-entry to below size-at-maturity. A size-structured model is fitted to three stocks that have shown indications of late-in-life...

  14. Interior points of the completely positive cone.

    NARCIS (Netherlands)

    Dür, Mirjam; Still, Georg J.


    A matrix A is called completely positive if it can be decomposed as A = BB^T with an entrywise nonnegative matrix B. The set of all such matrices is a convex cone. We provide a characterization of the interior of this cone as well as of its dual.

  15. A Practical Seedless Infrared Safe Cone Algorithm


    Salam, Gavin P.


    This writeup highlights the infrared unsafety of the "midpoint" cone jet-algorithm and provides a brief overview of why this is a serious issue. It then shows how one can build a safe (seedless) cone algorithm and discusses the potential impact on measurements.

  16. Cone Penetrometer N Factor Determination Testing Results

    Energy Technology Data Exchange (ETDEWEB)

    Follett, Jordan R.


    This document contains the results of testing activities to determine the empirical 'N Factor' for the cone penetrometer in kaolin clay simulant. The N Factor is used to releate resistance measurements taken with the cone penetrometer to shear strength.

  17. Cone calorimeter tests of wood composites (United States)

    Robert H. White; Kuma Sumathipala


    The cone calorimeter is widely used for the determination of the heat release rate (HRR) of building products and other materials. As part of an effort to increase the availability of cone calorimeter data on wood products, the U.S. Forest Products Laboratory and the American Wood Council conducted this study on composite wood products in cooperation with the Composite...

  18. Double Dirac cones in phononic crystals

    KAUST Repository

    Li, Yan


    A double Dirac cone is realized at the center of the Brillouin zone of a two-dimensional phononic crystal (PC) consisting of a triangular array of core-shell-structure cylinders in water. The double Dirac cone is induced by the accidental degeneracy of two double-degenerate Bloch states. Using a perturbation method, we demonstrate that the double Dirac cone is composed of two identical and overlapping Dirac cones whose linear slopes can also be accurately predicted from the method. Because the double Dirac cone occurs at a relatively low frequency, a slab of the PC can be mapped onto a slab of zero refractive index material by using a standard retrieval method. Total transmission without phase change and energy tunneling at the double Dirac point frequency are unambiguously demonstrated by two examples. Potential applications can be expected in diverse fields such as acoustic wave manipulations and energy flow control.

  19. Comparison of the effectiveness of three different disinfectant solutions in disinfection of gutta-percha cones in one minute

    Directory of Open Access Journals (Sweden)

    Hasheminya SM


    Full Text Available Background and Aim: Care must be taken during root canal therapy to prevent contamination of filling materials and avoid root canal contamination. Gutta-percha cones are now widely used to fill root canals. However they are not resistant to conventional sterilization processes in moist or dry heat. To keep the aseptic chain, gutta-percha cones require rapid chair side decontamination before use. Considering different methods for rapid decontamination of gutta-percha cones, use of chemical agents is the best. The purpose of this study was to compare the effectiveness of three different disinfectant solutions in rapid decontamination of gutta-percha cones in one minute Materials and Methods: In this experimental study, 360 gutta-percha cones were placed in bacterial suspensions of Staphylococcus aurous, Escherichia coli and Bacillus subtilis spore for 30 minutes, and then immersed in disinfectant solutions (Micro-10, Deconex 53 Plus, 5.25% sodium hypocholorite for 1 minute. After that, the cones were aseptically transferred to the test tubes containing sterile saline. This solution was diluted 10-fold and then cultured on in brain-heart-infusion agar and the number of colonies was estimated after 24 h incubation at 37ْC. A series of 5 previously sterilized cones was used as negative control to check the sterility of gutta-percha cones directly from the manufacturer's box. Another series of gutta-percha cones were considered as positive control group. Results: No bacterial growth was seen in different test groups and negative control group. Conclusion: Analysis of disinfectant effects of sodium hypochlorite, Micro10 and Deconex 53 plus showed that all of these solutions have bactericidal and sporocidal effect and are very efficient in surface disinfection of gutta–percha cones in one minute. Because of irritative effects and unpleasant odor of sodium hypochlorite, Deconex 53 plus and Micro10 can be used for rapid decontamination of gutta

  20. Glucose metabolism in Lactococcus lactis MG1363 under different aeration conditions: Requirement of acetate to sustain growth under microaerobic conditions

    DEFF Research Database (Denmark)

    Nordkvist, Mikkel; Jensen, N.B.S.; Villadsen, John


    resulted in acetate, CO2, and acetoin replacing formate and ethanol as end products. Under microaerobic conditions, growth came to a gradual halt, although more than 60% of the glucose was still left. A decline in growth was not observed during microaerobic cultivation when acetate was added to the medium....... We hypothesize that the decline in growth was due to a lack of acetyl coenzyme A (acetyl-CoA) needed for fatty acid synthesis since acetyl-CoA can be synthesized from acetate by means of acetate kinase and phosphotransacetylase activities....... with air was used as the reference). The maximum specific growth rate was high (0.78 to 0.91 h(-1)) under all aeration conditions but decreased with increasing aeration, and more than 90% of the glucose was converted to lactate. However, a shift in by-product formation was observed. Increasing aeration...

  1. Smart Growth and Transportation (United States)

    Describes the relationship between smart growth and transportation, focusing smart and sustainable street design, transit-oriented development, parking management, sustainable transportation planning, and related resources.

  2. Sustained delivery of insulin-like growth factor-1/hepatocyte growth factor stimulates endogenous cardiac repair in the chronic infarcted pig heart. (United States)

    Koudstaal, Stefan; Bastings, Maartje M C; Feyen, Dries A M; Waring, Cheryl D; van Slochteren, Frebus J; Dankers, Patricia Y W; Torella, Daniele; Sluijter, Joost P G; Nadal-Ginard, Bernardo; Doevendans, Pieter A; Ellison, Georgina M; Chamuleau, Steven A J


    Activation of endogenous cardiac stem/progenitor cells (eCSCs) can improve cardiac repair after acute myocardial infarction. We studied whether the in situ activation of eCSCs by insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) could be increased using a newly developed hydrogel in chronic myocardial infarction (MI). One-month post-MI pigs underwent NOGA-guided intramyocardial injections of IGF-1/HGF (GF: both 0.5 μg/mL, n = 5) or IGF-1/HGF incorporated in UPy hydrogel (UPy-GF; both 0.5 μg/mL, n = 5). UPy hydrogel without added growth factors was administered to four control (CTRL) pigs. Left ventricular ejection fraction was increased in the UPy-GF and GF animals compared to CTRLs. UPy-GF delivery reduced pathological hypertrophy, led to the formation of new, small cardiomyocytes, and increased capillarization. The eCSC population was increased almost fourfold in the border zone of the UPy-GF-treated hearts compared to CTRL hearts. These results show that IGF-1/HGF therapy led to an improved cardiac function in chronic MI and that effect size could be further increased by using UPy hydrogel.

  3. Sustainable nitrogen fertilisation in sweet pepper: assessing growth and fruit quality and the potential nitrate pollution from different organic manures. (United States)

    Gómez-López, María D; del Amor, Francisco M


    The use of organic cultivation with manures does not avoid the risk of high nitrate concentrations if nutrient management is inefficient. So we studied the influence of three organic manures combined or not with additional chemical fertilisers on growth and yield of sweet pepper (Capsicum annuum L.), and on the soil and plant N concentrations. After 3 years of organic cultivation, poultry manure caused the highest soil pollution. The evolution of nitrate and organic matter in soil showed a pattern close to that of plant growth. The addition of mineral fertiliser increased vegetative growth and yield, and a cumulative season effect was observed. In treatments with no additional mineral fertiliser N translocation from leaves to fruits happened. A cumulative effect of seasons on fruit quality and a reduction near to 30% was observed in the first fruit quality category after 3 years. The fruit vitamin C content was reduced by increasing N fertilisation. The effects of organic fertiliser on soil and plant growth and yield depended on the type of manure used, its rate, and consecutive crop seasons. Horse manure gave the best combination of agricultural and environmental characteristics and could be used without additional fertigation. © 2012 Society of Chemical Industry.

  4. Discovery of 2D Anisotropic Dirac Cones. (United States)

    Feng, Baojie; Zhang, Jin; Ito, Suguru; Arita, Masashi; Cheng, Cai; Chen, Lan; Wu, Kehui; Komori, Fumio; Sugino, Osamu; Miyamoto, Koji; Okuda, Taichi; Meng, Sheng; Matsuda, Iwao


    2D anisotropic Dirac cones are observed in χ3 borophene, a monolayer boron sheet, using high-resolution angle-resolved photoemission spectroscopy. The Dirac cones are centered at the X and X' points. The data also reveal that the hybridization between borophene and Ag(111) is very weak, which explains the preservation of the Dirac cones. As χ3 borophene has been predicated to be a superconductor, the results may stimulate further research interest in the novel physics of borophene, such as the interplay between Cooper pairs and the massless Dirac fermions. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Contemporary statecraft for sustained and 'sustainable' growth ...

    African Journals Online (AJOL)

    Focusing on state structure and behaviour, the 'good governance' agenda, political settlement, and the current path, this article describes and elaborates – in a problematic manner – the hurdles we will encounter in simultaneously walking and making the road of state construction that is messy, complex and replete with ...

  6. Contemporary statecraft for sustained and 'sustainable' growth

    African Journals Online (AJOL)

    our world? In full recognition of the fact that contemporary statecraft and the construction ..... the operations of core state developmental agencies (Jayasuriya, 2001: 188). .... Embeddedness provides sources of intelligence and channels of ...

  7. Correlation Between Cone Penetration Rate And Measured Cone Penetration Parameters In Silty Soils

    DEFF Research Database (Denmark)

    Poulsen, Rikke; Nielsen, Benjaminn Nordahl; Ibsen, Lars Bo


    penetration tests with varying penetration rates conducted at a test site where the subsoil primary consists of sandy silt. It is shown how a reduced penetration rate influences the cone penetration measurements e.g. the cone resistance, pore pressure, and sleeve friction.......This paper shows, how a change in cone penetration rate affects the cone penetration measurements, hence the cone resistance, pore pressure, and sleeve friction in silty soil. The standard rate of penetration is 20 mm/s, and it is generally accepted that undrained penetration occurs in clay while...... drained penetration occurs in sand. When lowering the penetration rate, the soil pore water starts to dissipate and a change in the drainage condition is seen. In intermediate soils such as silty soils, the standard cone penetration rate may result in a drainage condition that could be undrained...

  8. Metrizability of Cone Metric Spaces Via Renorming the Banach Spaces

    Directory of Open Access Journals (Sweden)

    Hossein Soleimani


    Full Text Available In this paper we show that by renorming an ordered Banach space, every cone $P$ can be converted to a normal cone with constant $K=1$ and consequently due to this approach every cone metric space is really a metric one and every theorem in metric space is valid for cone metric space automatically.

  9. Soft Cone Metric Spaces and Some Fixed Point Theorems


    Altıntaş, İsmet; Taşköprü, Kemal


    This paper is an introduction to soft cone metric spaces. We define the concept of soft cone metric via soft element, investigate soft converges in soft cone metric spaces and prove some fixed point theorems for contractive mappings on soft cone metric spaces.

  10. Do Private Sustainability Standards Contribute to Income Growth and Poverty Alleviation? A Comparison of Different Coffee Certification Schemes in Ethiopia

    Directory of Open Access Journals (Sweden)

    Fikadu Mitiku


    Full Text Available Private sustainability standards are increasingly important in food trade with developing countries, but the implications for smallholder farmers are still poorly understood. We analyze the implications of different coffee certification schemes in Ethiopia using cross-sectional survey data, and regression and propensity-score-matching techniques. We find that: Rainforest Alliance (RA and double Fairtrade-Organic (FT-Org certifications are associated with higher incomes and reduced poverty, mainly because of higher prices; Fairtrade (FT certification hardly affects welfare; and Organic (Org certification reduces incomes, chiefly due to lower yields. Cooperative heterogeneity importantly shapes these results. Results imply that private standards may not always deliver what they promise to consumers.

  11. The effect of female labour force in economic growth and sustainability in transition economies - case study for SEE countries

    Directory of Open Access Journals (Sweden)

    Majlinda Mazalliu


    Full Text Available In this research paper, the main theoretical arguments for discussions are as following: female labour force participation in transition countries, female employment in economic sectors and their main barriers, and the contributions of female labour force in economic growth. In methodology, the secondary data are used, and they are calculated through STATA program. The main analysis include: descriptive statistic, regression analysis and correlation matrix. Based on empirical results, the regression analysis has found that economic growth and government effectiveness has a negative impact on female labour force. Financial market development, enterprises reforms, and innovation have a positive impact on female labour force in SEE (South Eastern European countries. In T-statistic analysis all independent variables have shown a negative significance (T <2 on female labour force. In correlation, economic growth and financial development market have negative correlation on female labour force, but other variables have shown positive correlation. SEE countries should develop the female labour force in their economies, so their role may be crucial toward different economic problems and challenges in the modern economy.

  12. Performance Analysis of Cone Detection Algorithms

    CERN Document Server

    Mariotti, Letizia


    Many algorithms have been proposed to help clinicians evaluate cone density and spacing, as these may be related to the onset of retinal diseases. However, there has been no rigorous comparison of the performance of these algorithms. In addition, the performance of such algorithms is typically determined by comparison with human observers. Here we propose a technique to simulate realistic images of the cone mosaic. We use the simulated images to test the performance of two popular cone detection algorithms and we introduce an algorithm which is used by astronomers to detect stars in astronomical images. We use Free Response Operating Characteristic (FROC) curves to evaluate and compare the performance of the three algorithms. This allows us to optimize the performance of each algorithm. We observe that performance is significantly enhanced by up-sampling the images. We investigate the effect of noise and image quality on cone mosaic parameters estimated using the different algorithms, finding that the estimat...

  13. Promoting sustainable economic growth in South Africa through the production and export of low-carbon environmental goods

    Directory of Open Access Journals (Sweden)

    Antoinette van Niekerk


    Full Text Available Many countries, particularly those in the developing world, are under increasing pressure to improve their growth rates in order to tackle pressing economic problems at the domestic level. Increasing export volumes can make a positive contribution to a country’s economic growth rate, but it can also endanger the environment. How to reconcile the often conflicting phenomena of increased export activity, stronger economic growth and a lower carbon footprint is the focus of this study. A core outcome of the study was the creation of a single list using a cross-section of international sources, of low-carbon environmental goods, and their ranking according to their inherent ability to reduce greenhouse gas emissions, South Africa’s capacity to produce them, and their economic benefits, as reflected in the export opportunities they present. These export opportunities were revealed through the application of the Decision Support Model (DSM, an export market selection tool that incorporates a systematic filtering and screening system. The results of the analysis should help guide policymakers in their strategic deliberations on which export sectors to incentivise and support with a view to encouraging more ‘green’ growth in South Africa in the years ahead. diffusion of such goods. If the production and export of environmental goods were to increase, it could have a potentially positive effect on economic and environmental objectives, such as raising economic growth rates and lowering greenhouse gas intensity, respectively. For the purpose of this study, an analysis of four existing lists of environmental goods led to the identification of 39 core environmental goods. These 39 goods were ranked according to three criteria: i the potential environmental benefits of each environmental good, using consensus among role players as a proxy; ii South Africa’s capacity to produce each environmental good, using the Revealed Comparative Advantage (RCA

  14. Promoting sustainable economic growth in South Africa through the production and export of low-carbon environmental goods

    Directory of Open Access Journals (Sweden)

    Antoinette van Niekerk


    Full Text Available Many countries, particularly those in the developing world, are under increasing pressure to improve their growth rates in order to tackle pressing economic problems at the domestic level.  Increasing export volumes can make a positive contribution to a country’s economic growth rate, but it can also endanger the environment.  How to reconcile the often conflicting phenomena of increased export activity, stronger economic growth and a lower carbon footprint is the focus of this study.A core outcome of the study was the creation of a single list using a cross-section of international sources, of low-carbon environmental goods, and their ranking according to their inherent ability to reduce greenhouse gas emissions, South Africa’s capacity to produce them, and their economic benefits, as reflected in the export opportunities they present. These export opportunities were revealed through the application of the Decision Support Model (DSM, an export market selection tool that incorporates a systematic filtering and screening system.The results of the analysis should help guide policymakers in their strategic deliberations on which export sectors to incentivise and support with a view to encouraging more ‘green’ growth in South Africa in the years ahead.diffusion of such goods.  If the production and export of environmental goods were to increase, it could have a potentially positive effect on economic and environmental objectives, such as raising economic growth rates and lowering greenhouse gas intensity, respectively.  For the purpose of this study, an analysis of four existing lists of environmental goods led to the identification of 39 core environmental goods.  These 39 goods were ranked according to three criteria: i the potential environmental benefits of each environmental good, using consensus among role players as a proxy; ii South Africa’s capacity to produce each environmental good, using the Revealed Comparative Advantage

  15. Effect of the ICT Ecosystem Structure on the Sustainable Growth of ICT Firms: A Metafrontier Analysis on China, South Korea, the United States, and Japan

    Directory of Open Access Journals (Sweden)

    Kyoungsun Lee


    Full Text Available We study how the information and communications technology (ICT ecosystem affects the sustainable growth of ICT firms. For our study, we analyze the efficiencies of ICT firms in China, South Korea, the United States, and Japan, which are the current leaders in the global ICT industry, each with different ICT ecosystem structures. We use metafrontier analysis (MFA to compare the efficiencies among countries with different structures, and then use Tobit regression to identify the causes of the efficiency gaps. Our results reveal that the US has the highest efficiency, followed by Japan, South Korea, and China, in that order, and the countries with more balanced ICT ecosystems across sub-industries—manufacturing, software and IT services, content, and telecommunications—have more efficient ICT industries. This suggests that a more balanced industrial development is important to enhancing the overall competitiveness of the ICT industry.

  16. Extracellular Matrix (ECM Multilayer Membrane as a Sustained Releasing Growth Factor Delivery System for rhTGF-β3 in Articular Cartilage Repair.

    Directory of Open Access Journals (Sweden)

    Soon Sim Yang

    Full Text Available Recombinant human transforming growth factor beta-3 (rhTGF-β3 is a key regulator of chondrogenesis in stem cells and cartilage formation. We have developed a novel drug delivery system that continuously releases rhTGF-β3 using a multilayered extracellular matrix (ECM membrane. We hypothesize that the sustained release of rhTGF-β3 could activate stem cells and result in enhanced repair of cartilage defects. The properties and efficacy of the ECM multilayer-based delivery system (EMLDS are investigated using rhTGF-β3 as a candidate drug. The bioactivity of the released rhTGF-ß3 was evaluated through chondrogenic differentiation of mesenchymal stem cells (MSCs using western blot and circular dichroism (CD analyses in vitro. The cartilage reparability was evaluated through implanting EMLDS with endogenous and exogenous MSC in both in vivo and ex vivo models, respectively. In the results, the sustained release of rhTGF-ß3 was clearly observed over a prolonged period of time in vitro and the released rhTGF-β3 maintained its structural stability and biological activity. Successful cartilage repair was also demonstrated when rabbit MSCs were treated with rhTGF-β3-loaded EMLDS ((+ rhTGF-β3 EMLDS in an in vivo model and when rabbit chondrocytes and MSCs were treated in ex vivo models. Therefore, the multilayer ECM membrane could be a useful drug delivery system for cartilage repair.

  17. Cone-Parameter Convolution Semigroups and Their Subordination


    Pedersen, Jan; Sato, Ken-iti


    Convolution semigroups of probability measures with parameter in a cone in a Euclidean space generalize usual convolution semigroups with parameter in $[0,\\infty)$. A characterization of such semigroups is given and examples are studied. Subordination of cone-parameter convolution semigroups by cone-valued cone-parameter convolution semigroups is introduced. Its general description is given and inheritance properties are shown. In the study the distinction between cones with an...

  18. Microspectrophotometric evidence for cone monochromacy in sharks (United States)

    Hart, Nathan Scott; Theiss, Susan Michelle; Harahush, Blake Kristin; Collin, Shaun Patrick


    Sharks are apex predators, and their evolutionary success is in part due to an impressive array of sensory systems, including vision. The eyes of sharks are well developed and function over a wide range of light levels. However, whilst close relatives of the sharks—the rays and chimaeras—are known to have the potential for colour vision, an evolutionary trait thought to provide distinct survival advantages, evidence for colour vision in sharks remains equivocal. Using single-receptor microspectrophotometry, we measured the absorbance spectra of visual pigments located in the retinal photoreceptors of 17 species of shark. We show that, while the spectral tuning of the rod (wavelength of maximum absorbance, λmax 484-518 nm) and cone (λmax 532-561 nm) visual pigments varies between species, each shark has only a single long-wavelength-sensitive cone type. This suggests that sharks may be cone monochromats and, therefore, potentially colour blind. Whilst cone monochromacy on land is rare, it may be a common strategy in the marine environment: many aquatic mammals (whales, dolphins and seals) also possess only a single, green-sensitive cone type. It appears that both sharks and marine mammals may have arrived at the same visual design by convergent evolution. The spectral tuning of the rod and cone pigments of sharks is also discussed in relation to their visual ecology.

  19. Design of a trichromatic cone array.

    Directory of Open Access Journals (Sweden)

    Patrick Garrigan


    Full Text Available Cones with peak sensitivity to light at long (L, medium (M and short (S wavelengths are unequal in number on the human retina: S cones are rare (<10% while increasing in fraction from center to periphery, and the L/M cone proportions are highly variable between individuals. What optical properties of the eye, and statistical properties of natural scenes, might drive this organization? We found that the spatial-chromatic structure of natural scenes was largely symmetric between the L, M and S sensitivity bands. Given this symmetry, short wavelength attenuation by ocular media gave L/M cones a modest signal-to-noise advantage, which was amplified, especially in the denser central retina, by long-wavelength accommodation of the lens. Meanwhile, total information represented by the cone mosaic remained relatively insensitive to L/M proportions. Thus, the observed cone array design along with a long-wavelength accommodated lens provides a selective advantage: it is maximally informative.

  20. Sustainability and shared smart and mutual--green growth (SSaM-GG) in Korean medical waste management. (United States)

    Koo, Ja-Kong; Jeong, Seung-Ik


    Since medical insurance was introduced in the Republic of Korea, there have been several increases concerning medical waste. In order to solve these problems, we have applied life cycle assessment and life cycle cost. But these methods cannot be a perfect decision-making tool because they can only evaluate environmental and economic burdens. Thus, as one of many practical methods the shared smart and mutual - green growth considers economic growth, environmental protection, social justice, science technology and art, and mutual voluntarism when applied to medical waste management in the Republic of Korea. Four systems were considered: incineration, incineration with heat recovery, steam sterilisation, and microwave disinfection. This research study aimed to assess pollutant emissions from treatment, transport, and disposal. Global warming potential, photochemical oxidant creation potential, acidifications potential, and human toxicity are considered to be environmental impacts. Total investment cost, transport cost, operation, and maintenance cost for the medical waste are considered in the economy evaluations though life cycle cost. The social development, science technology and art, and mutual voluntarism are analysed through the Delphi-method conducted by expert groups related to medical waste. The result is that incineration with heat recovery is the best solution. However, when heat recovery is impossible, incineration without heat recovery becomes the next best choice. That is why 95% of medical waste is currently treated by both incineration and incineration with heat recovery within the Republic of Korea. © The Author(s) 2015.

  1. Orthopedic surgery and bone fracture pain are both significantly attenuated by sustained blockade of nerve growth factor. (United States)

    Majuta, Lisa A; Longo, Geraldine; Fealk, Michelle N; McCaffrey, Gwen; Mantyh, Patrick W


    The number of patients suffering from postoperative pain due to orthopedic surgery and bone fracture is projected to dramatically increase because the human life span, weight, and involvement in high-activity sports continue to rise worldwide. Joint replacement or bone fracture frequently results in skeletal pain that needs to be adequately controlled for the patient to fully participate in needed physical rehabilitation. Currently, the 2 major therapies used to control skeletal pain are nonsteroidal anti-inflammatory drugs and opiates, both of which have significant unwanted side effects. To assess the efficacy of novel therapies, mouse models of orthopedic and fracture pain were developed and evaluated here. These models, orthopedic surgery pain and bone fracture pain, resulted in skeletal pain-related behaviors that lasted 3 weeks and 8 to 10 weeks, respectively. These skeletal pain behaviors included spontaneous and palpation-induced nocifensive behaviors, dynamic weight bearing, limb use, and voluntary mechanical loading of the injured hind limb. Administration of anti-nerve growth factor before orthopedic surgery or after bone fracture attenuated skeletal pain behaviors by 40% to 70% depending on the end point being assessed. These data suggest that nerve growth factor is involved in driving pain due to orthopedic surgery or bone fracture. These animal models may be useful in developing an understanding of the mechanisms that drive postoperative orthopedic and bone fracture pain and the development of novel therapies to treat these skeletal pains.

  2. Sustainable Practices Innovation (United States)

    Better sustainability means more environmentally conscious and efficient businesses and communities. EPA helps modify the way we consume energy, deal with waste, and grow our economy through programs such as Energy Star, E3, Smart Growth, and WaterSense.

  3. Rapid synaptic vesicle endocytosis in cone photoreceptors of salamander retina (United States)

    Van Hook, Matthew J.; Thoreson, Wallace B.


    Following synaptic vesicle exocytosis, neurons retrieve the fused membrane by a process of endocytosis in order to provide a supply of vesicles for subsequent release and maintain the presynaptic active zone. Rod and cone photoreceptors use a specialized structure called the synaptic ribbon that enables them to sustain high rates of neurotransmitter release. They must also employ mechanisms of synaptic vesicle endocytosis capable of keeping up with release. While much is known about endocytosis at another retinal ribbon synapse, that of the goldfish Mb1 bipolar cell, less is known about endocytosis in photoreceptors. We used capacitance recording techniques to measure vesicle membrane fusion and retrieval in photoreceptors from salamander retinal slices. We found that application of brief depolarizing steps (endocytosis with a time constant ~250 ms. In some cases, the capacitance trace overshot the baseline, indicating excess endocytosis. Calcium had no effect on the time constant, but enhanced excess endocytosis resulting in a faster rate of membrane retrieval. Surprisingly, endocytosis was unaffected by blockers of dynamin, suggesting that cone endocytosis is dynamin-independent. This contrasts with synaptic vesicle endocytosis in rods, which was inhibited by the dynamin inhibitor dynasore and GTPγS introduced through the patch pipette, suggesting that the two photoreceptor types employ distinct pathways for vesicle retrieval. The fast kinetics of synaptic vesicle endocytosis in photoreceptors likely enables these cells to maintain a high rate of transmitter release, allowing them to faithfully signal changes in illumination to second-order neurons. PMID:23238726

  4. Sustainability of National Cohesion

    Directory of Open Access Journals (Sweden)

    Andrei Mihai Cristea


    Full Text Available In the European Union, cohesion policy is the third country after the domestic and social policy, as this policy is a tool for economic growth and also a balancing factor. Through its solidarity funds contribute to the other sectorial policies: the Common Agricultural Policy, social policy, environmental policy. This article aims to demonstrate the importance of cohesion policy in the national economy and how to improve its implementation by ensuring sustainable development and sustainable economic growth

  5. Efficient Encapsulation and Sustained Release of Basic Fibroblast Growth Factor in Nanofilm: Extension of the Feeding Cycle of Human Induced Pluripotent Stem Cell Culture. (United States)

    Han, Uiyoung; Park, Hee Ho; Kim, Yu Jin; Park, Tai Hyun; Park, Ju Hyun; Hong, Jinkee


    Basic fibroblast growth factor (bFGF) has an established pivotal function in biomedical engineering, especially for the human pluripotent stem cells (iPSCs). However, the limitation of bFGF is the ease of denaturation under normal physiological conditions, inducing loss of its activity. In this study, we designed multi-trilayered nanofilm composed of a repeating polycation/polyanion/bFGF structure, which has high loading efficiency and short buildup time. We also investigated that the loading and release of bFGF from the nanofilm with two parameters (counter-polyanion and film architectures). Then, we prepared the optimized nanofilm which maintains a sustained bFGF level in physiological condition to apply the nanofilm to human iPSCs culture. The amount of bFGF release from 12 trilayer nanofilm was 36.4 ng/cm(2), and activity of bFGF encapsulated into the nanofilm was maintained (60%) until 72 h during incubation at 37 °C. As a result, the iPSCs grown in the presence of the nanofilm with tridaily replacement of growth medium maintained undifferentiated morphology and expression levels of pluripotency marker proteins.

  6. Submicrometer Hollow Bioglass Cones Deposited by Radio Frequency Magnetron Sputtering: Formation Mechanism, Properties, and Prospective Biomedical Applications. (United States)

    Popa, A C; Stan, G E; Besleaga, C; Ion, L; Maraloiu, V A; Tulyaganov, D U; Ferreira, J M F


    This work reports on the unprecedented magnetron sputtering deposition of submicrometric hollow cones of bioactive glass at low temperature in the absence of any template or catalyst. The influence of sputtering conditions on the formation and development of bioglass cones was studied. It was shown that larger populations of well-developed cones could be achieved by increasing the argon sputtering pressure. A mechanism describing the growth of bioglass hollow cones is presented, offering the links for process control and reproducibility of the cone features. The composition, structure, and morphology of the as-synthesized hollow cones were investigated by energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), grazing incidence geometry X-ray diffraction (GIXRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM)-selected area electron diffraction (SAED). The in vitro biological performance, assessed by degradation tests (ISO 10993-14) and cytocompatibility assays (ISO 10993-5) in endothelial cell cultures, was excellent. This allied with resorbability and the unique morphological features make the submicrometer hollow cones interesting candidate material devices for focal transitory permeabilization of the blood-brain barrier in the treatment of carcinoma and neurodegenerative disorders.

  7. Calpain-Mediated Positional Information Directs Cell Wall Orientation to Sustain Plant Stem Cell Activity, Growth and Development. (United States)

    Liang, Zhe; Brown, Roy C; Fletcher, Jennifer C; Opsahl-Sorteberg, Hilde-Gunn


    Eukaryotic development and stem cell control depend on the integration of cell positional sensing with cell cycle control and cell wall positioning, yet few factors that directly link these events are known. The DEFECTIVE KERNEL1 (DEK1) gene encoding the unique plant calpain protein is fundamental for development and growth, being essential to confer and maintain epidermal cell identity that allows development beyond the globular embryo stage. We show that DEK1 expression is highest in the actively dividing cells of seeds, meristems and vasculature. We further show that eliminating Arabidopsis DEK1 function leads to changes in developmental cues from the first zygotic division onward, altered microtubule patterns and misshapen cells, resulting in early embryo abortion. Expression of the embryonic marker genes WOX2, ATML1, PIN4, WUS and STM, related to axis organization, cell identity and meristem functions, is also altered in dek1 embryos. By monitoring cell layer-specific DEK1 down-regulation, we show that L1- and 35S-induced down-regulation mainly affects stem cell functions, causing severe shoot apical meristem phenotypes. These results are consistent with a requirement for DEK1 to direct layer-specific cellular activities and set downstream developmental cues. Our data suggest that DEK1 may anchor cell wall positions and control cell division and differentiation, thereby balancing the plant's requirement to maintain totipotent stem cell reservoirs while simultaneously directing growth and organ formation. A role for DEK1 in regulating microtubule-orchestrated cell wall orientation during cell division can explain its effects on embryonic development, and suggests a more general function for calpains in microtubule organization in eukaryotic cells. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email:

  8. Clinical course, genetic etiology, and visual outcome in cone and cone-rod dystrophy

    NARCIS (Netherlands)

    Thiadens, A.A.; Phan, T.M.; Zekveld-Vroon, R.C.; Leroy, B.P.; Born, L.I. van den; Hoyng, C.B.; Klaver, C.C.; Writing Committee for the Cone Disorders Study Group, C.; Roosing, S.; Pott, J.W.; van Schooneveld, M.J.; van Moll-Ramirez, N.; van Genderen, M.M.; Boon, C.J.F.; Hollander, A.I. den; Bergen, A.A.; De Baere, E.; Cremers, F.P.; Lotery, A.J.


    OBJECTIVE: To evaluate the clinical course, genetic etiology, and visual prognosis in patients with cone dystrophy (CD) and cone-rod dystrophy (CRD). DESIGN: Clinic-based, longitudinal, multicenter study. PARTICIPANTS: Consecutive probands with CD (N = 98), CRD (N = 83), and affected relatives (N =

  9. Clinical Course, Genetic Etiology, and Visual Outcome in Cone and Cone-Rod Dystrophy

    NARCIS (Netherlands)

    Thiadens, Alberta A. H. J.; Phan, T. My Lan; Zekveld-Vroon, Renate C.; Leroy, Bart P.; van den Born, L. Ingeborgh; Hoyng, Carel B.; Klaver, Caroline C. W.; Roosing, Susanne; Pott, Jan-Willem R.; van Schooneveld, Mary J.; van Moll-Ramirez, Norka; van Genderen, Maria M.; Boon, Camiel J. F.; den Hollander, Anneke I.; Bergen, Arthur A. B.; De Baere, Elfride; Cremers, Frans P. M.; Lotery, Andrew J.

    Objective: To evaluate the clinical course, genetic etiology, and visual prognosis in patients with cone dystrophy (CD) and cone-rod dystrophy (CRD). Design: Clinic-based, longitudinal, multicenter study. Participants: Consecutive probands with CD (N = 98), CRD (N = 83), and affected relatives (N =

  10. Genome-wide association mapping for root cone angle in rice. (United States)

    Bettembourg, Mathilde; Dardou, Audrey; Audebert, Alain; Thomas, Emilie; Frouin, Julien; Guiderdoni, Emmanuel; Ahmadi, Nourollah; Perin, Christophe; Dievart, Anne; Courtois, Brigitte


    Plant root systems play a major role in anchoring and in water and nutrient uptake from the soil. The root cone angle is an important parameter of the root system architecture because, combined with root depth, it helps to determine the volume of soil explored by the plant. Two genes, DRO1 and SOR1, and several QTLs for root cone angle have been discovered in the last 5 years. To find other QTLs linked to root cone angle, a genome-wide association mapping study was conducted on two panels of 162 indica and 169 japonica rice accessions genotyped with two sets of SNP markers (genotyping-by-sequencing set with approximately 16,000 markers and high-density-rice-array set with approximately 300,000 markers). The root cone angle of all accessions was measured using a screen protractor on images taken after 1 month of plant growth in the Rhizoscope phenotyping system. The distribution of the root cone angle in the indica panel was Gaussian, but several accessions of the japonica panel (all the bulus from Indonesia and three temperate japonicas from Nepal or India) appeared as outliers with a very wide root cone angle. The data were submitted to association mapping using a mixed model with control of structure and kinship. A total of 15 QTLs for the indica panel and 40 QTLs for the japonica panel were detected. Genes underlying these QTLs (+/-50 kb from the significant markers) were analyzed. We focused our analysis on auxin-related genes, kinases, and genes involved in root developmental processes and identified 8 particularly interesting genes. The present study identifies new sources of wide root cone angle in rice, proposes ways to bypass some drawbacks of association mapping to further understand the genetics of the trait and identifies candidate genes deserving further investigation.

  11. Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosis.

    Directory of Open Access Journals (Sweden)

    Alexis-Pierre Bemelmans


    Full Text Available RPE65 is specifically expressed in the retinal pigment epithelium and is essential for the recycling of 11-cis-retinal, the chromophore of rod and cone opsins. In humans, mutations in RPE65 lead to Leber congenital amaurosis or early-onset retinal dystrophy, a severe form of retinitis pigmentosa. The proof of feasibility of gene therapy for RPE65 deficiency has already been established in a dog model of Leber congenital amaurosis, but rescue of the cone function, although crucial for human high-acuity vision, has never been strictly proven. In Rpe65 knockout mice, photoreceptors show a drastically reduced light sensitivity and are subject to degeneration, the cone photoreceptors being lost at early stages of the disease. In the present study, we address the question of whether application of a lentiviral vector expressing the Rpe65 mouse cDNA prevents cone degeneration and restores cone function in Rpe65 knockout mice.Subretinal injection of the vector in Rpe65-deficient mice led to sustained expression of Rpe65 in the retinal pigment epithelium. Electroretinogram recordings showed that Rpe65 gene transfer restored retinal function to a near-normal pattern. We performed histological analyses using cone-specific markers and demonstrated that Rpe65 gene transfer completely prevented cone degeneration until at least four months, an age at which almost all cones have degenerated in the untreated Rpe65-deficient mouse. We established an algorithm that allows prediction of the cone-rescue area as a function of transgene expression, which should be a useful tool for future clinical trials. Finally, in mice deficient for both RPE65 and rod transducin, Rpe65 gene transfer restored cone function when applied at an early stage of the disease.By demonstrating that lentivirus-mediated Rpe65 gene transfer protects and restores the function of cones in the Rpe65(-/- mouse, this study reinforces the therapeutic value of gene therapy for RPE65 deficiencies

  12. Turning cones off: the role of the 9-methyl group of retinal in red cones. (United States)

    Estevez, Maureen E; Ala-Laurila, Petri; Crouch, Rosalie K; Cornwall, M Carter


    Our ability to see in bright light depends critically on the rapid rate at which cone photoreceptors detect and adapt to changes in illumination. This is achieved, in part, by their rapid response termination. In this study, we investigate the hypothesis that this rapid termination of the response in red cones is dependent on interactions between the 9-methyl group of retinal and red cone opsin, which are required for timely metarhodopsin (Meta) II decay. We used single-cell electrical recordings of flash responses to assess the kinetics of response termination and to calculate guanylyl cyclase (GC) rates in salamander red cones containing native visual pigment as well as visual pigment regenerated with 11-cis 9-demethyl retinal, an analogue of retinal in which the 9-methyl group is missing. After exposure to bright light that photoactivated more than approximately 0.2% of the pigment, red cones containing the analogue pigment had a slower recovery of both flash response amplitudes and GC rates (up to 10 times slower at high bleaches) than red cones containing 11-cis retinal. This finding is consistent with previously published biochemical data demonstrating that red cone opsin regenerated in vitro with 11-cis 9-demethyl retinal exhibited prolonged activation as a result of slowed Meta II decay. Our results suggest that two different mechanisms regulate the recovery of responsiveness in red cones after exposure to light. We propose a model in which the response recovery in red cones can be regulated (particularly at high light intensities) by the Meta II decay rate if that rate has been inhibited. In red cones, the interaction of the 9-methyl group of retinal with opsin promotes efficient Meta II decay and, thus, the rapid rate of recovery.

  13. Nuclear Symbiosis - A Means to Achieve Sustainable Nuclear Growth while Limiting the Spread of Sensititive Nuclear Technology

    Energy Technology Data Exchange (ETDEWEB)

    David Shropshire


    Global growth of nuclear energy in the 21st century is creating new challenges to limit the spread of nuclear technology without hindering adoption in countries now considering nuclear power. Independent nuclear states desire autonomy over energy choices and seek energy independence. However, this independence comes with high costs for development of new indigenous fuel cycle capabilities. Nuclear supplier states and expert groups have proposed fuel supply assurance mechanisms such as fuel take-back services, international enrichment services and fuel banks in exchange for recipient state concessions on the development of sensitive technologies. Nuclear states are slow to accept any concessions to their rights under the Non-Proliferation Treaty. To date, decisions not to develop indigenous fuel cycle capabilities have been driven primarily by economics. However, additional incentives may be required to offset a nuclear state’s perceived loss of energy independence. This paper proposes alternative economic development incentives that could help countries decide to forgo development of sensitive nuclear technologies. The incentives are created through a nuclear-centered industrial complex with “symbiotic” links to indigenous economic opportunities. This paper also describes a practical tool called the “Nuclear Materials Exchange” for identifying these opportunities.

  14. Fully aligned academic health centers: a model for 21st-century job creation and sustainable economic growth. (United States)

    Reece, E Albert; Chrencik, Robert A; Miller, Edward D


    Alignment is the degree to which component parts of academic health centers (AHCs) work cohesively. Full alignment allows AHCs to act quickly and cohesively toward common goals and to take advantage of opportunities that present themselves, particularly where collaboration is essential. Maryland's two major AHCs-University of Maryland Medicine (UMM) and Johns Hopkins Medicine (JHM)-have experienced periods of significant misalignment during each of their histories. Their most recent periods of misalignment caused significant negative economic and academic impacts. However, the process of realigning their clinical and research missions has not only given them a renewed economic vigor but has also paid significant dividends for the state of Maryland, helping it weather the current recession much better than other regions of the country. The two AHCs' continued economic success during the recession has led Maryland lawmakers to increasingly seek out their expertise in attempts to stimulate economic development. Indeed, UMM, JHM, and other fully aligned AHCs have shown that they can be powerful economic engines and offer a model of job growth and economic development in the 21st century.

  15. Ecophysiological variables influencing Aleppo pine seed and cone production: a review. (United States)

    Ayari, Abdelaziz; Khouja, Mohamed Larbi


    The most interesting factors associated with seed and cone production of Aleppo pine were largely reviewed to identify broad patterns and potential effectiveness of reforestation efforts and planning. Aleppo pine cone production and seed yields are relatively variable, with differences between spatial and temporal influences. These differences are considered, mainly between (i) year, (ii) stand characteristics and (iii) individual tree measurements. Annual variability among populations was recorded for cone production per tree, based on influencing factors such as genetic characteristics, wetness, nutrient availability, insect pests and disease. In addition, some factors may affect Aleppo pine tree growth directly but may be affecting seed and cone production indirectly. Therefore, reduced stand density results in less competition among Aleppo pine trees and accompanying understory flora, which subsequently increases the stem diameter and other tree dimensions, including seed production. This review suggests that reforestation planning, particularly thinning, will result in improved tree morphology that will increase Aleppo pine seed and cone crops. Wildfire intensity and stand conditions such as light and soil nutrient status are also examined.

  16. Natural gas markets integration in the Southern Cone: analysis of interests and stakeholders; Perspectivas para a integracao gasifera no Cone Sul: uma analise dos principais interesses e interessados

    Energy Technology Data Exchange (ETDEWEB)

    Villas Boas, Marina Vieira [PETROBRAS, Rio de Janeiro, RJ (Brazil)


    Natural gas has been recently gaining importance in the world energy mix especially because of its economical and environmental advantages but also because of technological and geopolitical issues. In the Southern Cone, natural gas demand shall maintain its upward trend in the next years mainly due to its use in power generation. This region owns significant natural gas reserves and, at the same time, a growing and with high potential market. In this scenario, natural gas markets integration is seen simultaneously as an opportunity and a necessity as it can contribute to demand and production interconnection, price competitiveness and security of supply. Nevertheless, there are important barriers to the consolidation of natural gas market integration in the Southern Cone region that have to be overcome. For the natural gas markets integration to be a sustainable project it is necessary to identify the major stakeholders and their interests and pursue a balance between them. (author)

  17. Insulin, IGF-I, and muscle MAPK pathway responses after sustained exercise and their contribution to growth and lipid metabolism regulation in gilthead sea bream. (United States)

    Sánchez-Gurmaches, J; Cruz-Garcia, L; Ibarz, A; Fernández-Borrás, J; Blasco, J; Gutiérrez, J; Navarro, I


    Herein, we studied whether sustained exercise positively affects growth of gilthead sea bream by alterations in a) plasma concentrations of insulin and IGF-I, b) signaling pathways in muscle, or c) regulation of lipid metabolism. Specifically, we evaluated the effects of moderated swimming (1.5 body lengths per second; BL/s) on the circulating concentrations of insulin and IGF-I, morphometric parameters, and expression of genes related to lipid metabolism in gilthead sea bream (80-90 g BW). Exercise increased the specific growth rate (P growth and metabolic homeostasis during swimming. The observed decrease in plasma insulin concentrations (P = 0.016) could favor the mobilization of tissue reserves in exercised fish. In this sense, the increase in liver fatty acid content (P = 0.041) and the changes in expression of peroxisome proliferator-activated receptors PPARα (P = 0.017) and PPARγ (P = 0.033) indicated a hepatic lipid mobilization. Concentration of glycogen in both white and red muscles was decreased (P = 0.021 and P = 0.017, respectively) in exercised (n = 12) relative to control (n = 12) gilthead sea bream, whereas concentrations of glucose (P = 0.016) and lactate (P = 0.0007) were decreased only in red muscle, indicating the use of these substrates. No changes in the glucose transporter and in lipoprotein lipase mRNA expression were found in any of the tissues studied. Exercised sea bream had decreased content of PPARβ mRNA in white and red muscle relative to control sea bream expression (P = 0.001 and P = 0.049, respectively). Mitogen-activated protein kinase phosphorylation was significantly down-regulated in both white and red muscles of exercised sea bream (P = 0.0374 and P = 0.0371, respectively). Tumor necrosis factor-α expression of white muscle was down-regulated in exercised gilthead sea bream (P = 0.045). Collectively, these results contribute to the knowledge base about hormonal regulation of growth and lipid metabolism in exercised gilthead

  18. Interrelationships Between 3 Keratoconic Cone Parameters. (United States)

    Tu, Kyaw L; Tourkmani, Abdo K; Srinivas, Singaram


    To find out the interrelationships between 3 parameters of the keratoconic cone. A total of 101 keratoconic eyes of 58 patients were included in this retrospective case series study. A complete eye examination was performed. Kmax (K) and pachymetry at the thinnest point (T) were obtained from the Pentacam tomographer. The vertex to thinnest pachymetry distance (D for decentration) was calculated using trigonometry. Pearson correlation coefficients between T and D, between T and K, and between D and K were calculated. There is a statistically significant positive correlation between thinnest point pachymetry and decentration (R = 0.366, P = 0.0002) and also statistically significant negative correlation between thinnest point pachymetry and Kmax (R = -0.719, P < 0.00001) and decentration and Kmax (R = -0.281, P = 0.0044). The interrelationships between the 3 keratoconic cone parameters suggest that the thinner cones are largely central, that is, decenter less, but show greater steepening.

  19. Hygroscopic motions of fossil conifer cones. (United States)

    Poppinga, Simon; Nestle, Nikolaus; Šandor, Andrea; Reible, Bruno; Masselter, Tom; Bruchmann, Bernd; Speck, Thomas


    Conifer cones represent natural, woody compliant structures which move their scales as passive responses to changes in environmental humidity. Here we report on water-driven opening and closing motions in coalified conifer cones from the Eemian Interglacial (approx. 126,000-113,000 years BP) and from the Middle Miocene (approx. 16.5 to 11.5 million years BP). These cones represent by far the oldest documented evidence of plant parts showing full functionality of such passive hydraulically actuated motion. The functional resilience of these structures is far beyond the biological purpose of seed dispersal and protection and is because of a low level of mineralization of the fossils. Our analysis emphasizes the functional-morphological integrity of these biological compliant mechanisms which, in addition to their biological fascination, are potentially also role models for resilient and maintenance-free biomimetic applications (e.g., adaptive and autonomously moving structures including passive hydraulic actuators).

  20. Tantalum Cones in Revision Total Knee Arthroplasty. (United States)

    Kim, Eric G; Patel, Nirav K; Chughtai, Morad; Elmallah, Randa D K; Delanois, Ronald E; Harwin, Steven F; Mont, Michael A


    The best strategy to address large bony defects in revision total knee arthroplasty has yet to be determined. The relatively recent development of porous tantalum cones and their use to address massive bone loss in knee arthroplasty has shown promising short- and intermediate-term results. The purpose of this review is to present the current literature on: (1) basic science of porous tantalum, (2) classification and treatment for bone loss, (3) clinical results, and (4) evolution of newer generation cones. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  1. Sedimentary Biosignatures of Social Organization in Cone-Forming Filamentous Bacteria (United States)

    Tice, M. M.; Gong, J.; Zeng, Z.; Sneed, J.; Wehner, M.; Sparks, D. W.


    Conical mats consisting of centimeter-scale steep-sided cones growing above flat basal films form some of the most distinctive fossil microbial communities in the geologic record. Cones have been hypothesized to form by the initially random motion of filamentous bacteria into small tangled clumps followed by the phototactic motion of the same bacteria up resulting slopes. More recent models of cone development suggest that they form in response to growth in stagnant fluids where diffusion limits exchange of nutrients and wastes with the environment. Determining the biological and environmental factors that promote cone formation will be important for interpreting the geological record of fossil mats and stromatolites, on Earth and potentially on Mars. Here we report the results of new experiments demonstrating complex social organization of cone-forming communities and a novel biosignature of the growth of such communities on sandy sediments, as well as detection of that biosignature in 3.2 Ga fossil mats of the Moodies Group (Barberton greenstone belt, South Africa). In order to investigate the processes involved in cone formation, we grew cultures of a filamentous cyanobacterium originally isolated from tufted cones in Yellowstone National Park, Montana, U.S.A. (Leptolyngbya sp. Y-WT-2000 Cl 1). During early mat development, filaments coat sand grain surfaces and aggregate into ~100-μm-long tufts, or mutually aligned bundles of filaments. Tufts are highly motile, bridging sand grains and merging to form larger tufts. After 10-14 days of growth, tufts aggregate during the early morning into centers composed of many tufts that wave vertically and along the sand surface. Centers move across the sediment surface during the middle of the day and merge along bridging tufts. These bridges transmit force to the underlying sediment and are capable of rolling sand grains. At this stage, mats are composed of small mobile centers that disperse along streams of co

  2. Collisionless loss-cone refilling: there is no final parsec problem (United States)

    Gualandris, Alessia; Read, Justin I.; Dehnen, Walter; Bortolas, Elisa


    Coalescing massive black hole binaries, formed during galaxy mergers, are expected to be a primary source of low-frequency gravitational waves. Yet in isolated gas-free spherical stellar systems, the hardening of the binary stalls at parsec-scale separations owing to the inefficiency of relaxation-driven loss-cone refilling. Repopulation via collisionless orbit diffusion in triaxial systems is more efficient, but published simulation results are contradictory. While sustained hardening has been reported in simulations of galaxy mergers with N ˜ 106 stars and in early simulations of rotating models, in isolated non-rotating triaxial models the hardening rate continues to fall with increasing N, a signature of spurious two-body relaxation. We present a novel approach for studying loss-cone repopulation in galactic nuclei. Since loss-cone repopulation in triaxial systems owes to orbit diffusion, it is a purely collisionless phenomenon and can be studied with an approximated force calculation technique, provided the force errors are well behaved and sufficiently small. We achieve this using an accurate fast multipole method and define a proxy for the hardening rate that depends only on stellar angular momenta. We find that the loss cone is efficiently replenished even in very mildly triaxial models (with axis ratios 1:0.9:0.8). Such triaxiality is unavoidable following galactic mergers and can drive binaries into the gravitational wave regime. We conclude that there is no `final parsec problem'.

  3. Gene therapy rescues cone function in congenital achromatopsia

    National Research Council Canada - National Science Library

    Komáromy, András M; Alexander, John J; Rowlan, Jessica S; Garcia, Monique M; Chiodo, Vince A; Kaya, Asli; Tanaka, Jacqueline C; Acland, Gregory M; Hauswirth, William W; Aguirre, Gustavo D


    .... We demonstrate that rAAV-mediated gene replacement therapy with different forms of the human red cone opsin promoter led to the restoration of cone function and day vision in two canine models...

  4. Sustained-released mixture of vascular endothelial growth factor 165 and fibrin glue strengthens healing of ileal anastomoses in a rabbit model with intraperitoneal infection. (United States)

    Li, Zhanwu; Wang, Wenjun; Wang, Xiaozhou; Jiang, Lei; Wang, Fengyi; Liu, Qiang


    To investigate the effects of a sustained-released mixture of vascular endothelial growth factor 165 (VEGF165) and fibrin glue (FG) local administration on postoperative rabbit ileal anastomoses. One hundred twenty-eight male and female New Zealand white rabbits underwent intraperitoneal infection subsequent ileal anastomosis surgery were divided randomly into 4 groups, including 32 animals in each, applied with saline solution, FG, rhVEGF165 and a mixture of rhVEGF165 with FG (VEGF + FG) on the anastomoses, respectively. The incidences of anastomotic leakage were observed. Histopathological examination for inflammatory infiltration, fibroblast proliferation, and capillary vascular proliferation were performed. Then, bursting pressure and hydroxyproline concentrations were assessed in anastomoses sits on postoperative days 3, 5, 7, and 14. Rabbits in VEGF + FG group had the lowest incidence of leakage (P < 0.05). Histological evaluations revealed that granulation tissue was formed on days 5 after anastomosis; fibroblast proliferation and capillary vascular proliferation were significantly increased on days 7 and 14 in VEGF + FG group. Furthermore, there was a statistically significant difference in the mean bursting pressures between VEGF + FG group and other groups on days 7 and 14 (P < 0.05), and rabbits in VEGF + FG group exhibited a higher concentration than VEGF group (P < 0.05) and FG group (P < 0.05) on day 14. Administration of VEGF165 mixed with FG to ileal anastomosis accelerates wound healing and enhances the anastomosis by increased angiogenesis.

  5. Effects of scoria-cone eruptions upon nearby human communities (United States)

    Ort, M.H.; Elson, M.D.; Anderson, K.C.; Duffield, W.A.; Hooten, J.A.; Champion, D.E.; Waring, G.


    Scoria-cone eruptions are typically low in volume and explosivity compared with eruptions from stratovolcanoes, but they can affect local populations profoundly. Scoria-cone eruption effects vary dramatically due to eruption style, tephra blanket extent, climate, types of land use, the culture and complexity of the affected group, and resulting governmental action. A comparison of a historic eruption (Pari??cutin, Me??xico) with prehistoric eruptions (herein we primarily focus on Sunset Crater in northern Arizona, USA) elucidates the controls on and effects of these variables. Long-term effects of lava flows extend little beyond the flow edges. These flows, however, can be used for defensive purposes, providing refuges from invasion for those who know them well. In arid lands, tephra blankets serve as mulches, decreasing runoff and evaporation, increasing infiltration, and regulating soil temperature. Management and retention of these scoria mulches, which can open new areas for agriculture, become a priority for farming communities. In humid areas, though, the tephra blanket may impede plant growth and increase erosion. Cultural responses to eruptions vary, from cultural collapse, through fragmentation of society, dramatic changes, and development of new technologies, to little apparent change. Eruptions may also be viewed as retribution for poor behavior, and attempts are made to mollify angry gods. ?? 2008 Geological Society of America.

  6. Closed graph and open mapping theorems for normed cones

    Indian Academy of Sciences (India)

    A quasi-normed cone is a pair (, ) such that is a (not necessarily cancellative) cone and is a quasi-norm on . The aim of this paper is to prove a closed graph and an open mapping type theorem for quasi-normed cones. This is done with the help of appropriate notions of completeness, continuity and openness that ...

  7. Cones and craters on Mount Pavagadh, Deccan Traps: Rootless ...

    Indian Academy of Sciences (India)

    Rootless cones, also (erroneously) called pseudocraters, form due to explosions that ensue when a lava flow enters a surface water body, ice, or wet ground. They do not represent primary vents connected by vertical conduits to a subsurface magma source. Rootless cones in Iceland are well studied. Cones on Mars ...

  8. Comparative analysis between mandibular positions in centric relation and maximum intercuspation by cone beam computed tomography (CONE-BEAM)

    National Research Council Canada - National Science Library

    Ferreira, Amanda de Freitas; Henriques, João César Guimarães; Almeida, Guilherme Araújo; Machado, Asbel Rodrigues; Machado, Naila Aparecida de Godoi; Fernandes Neto, Alfredo Júlio


    ...) and maximum intercuspation (MI), using computed tomography volumetric cone beam (cone beam method). The sample of the study consisted of 10 asymptomatic young adult patients divided into two types of standard occlusion...

  9. Hyperkahler cones and orthogonal Wolf spaces

    NARCIS (Netherlands)

    Anguelova, L.K.; Rocek, M.; Vandoren, S.


    We construct the hyperk¨ahler cones corresponding to the quaternion-K¨ahler orthogonal Wolf spaces SO(n+4)/ SO(n)×SO(4) and their non-compact versions, which appear in hypermultiplet couplings to N = 2 supergravity. The geometry is completely encoded by a single function, the hyperk¨ahler

  10. Cone beam computed tomography in veterinary dentistry

    NARCIS (Netherlands)

    van Thielen, B.; Siguenza, F.; Hassan, B.


    The purpose of this study was to assess the feasibility of cone beam computed tomography (CBCT) in imaging dogs and cats for diagnostic dental veterinary applications. CBCT scans of heads of six dogs and two cats were made. Dental panoramic and multi-planar reformatted (MPR) para-sagittal

  11. Chloride equilibrium potential in salamander cones

    Directory of Open Access Journals (Sweden)

    Bryson Eric J


    Full Text Available Abstract Background GABAergic inhibition and effects of intracellular chloride ions on calcium channel activity have been proposed to regulate neurotransmission from photoreceptors. To assess the impact of these and other chloride-dependent mechanisms on release from cones, the chloride equilibrium potential (ECl was determined in red-sensitive, large single cones from the tiger salamander retinal slice. Results Whole cell recordings were done using gramicidin perforated patch techniques to maintain endogenous Cl- levels. Membrane potentials were corrected for liquid junction potentials. Cone resting potentials were found to average -46 mV. To measure ECl, we applied long depolarizing steps to activate the calcium-activated chloride current (ICl(Ca and then determined the reversal potential for the current component that was inhibited by the Cl- channel blocker, niflumic acid. With this method, ECl was found to average -46 mV. In a complementary approach, we used a Cl-sensitive dye, MEQ, to measure the Cl- flux produced by depolarization with elevated concentrations of K+. The membrane potentials produced by the various high K+ solutions were measured in separate current clamp experiments. Consistent with electrophysiological experiments, MEQ fluorescence measurements indicated that ECl was below -36 mV. Conclusions The results of this study indicate that ECl is close to the dark resting potential. This will minimize the impact of chloride-dependent presynaptic mechanisms in cone terminals involving GABAa receptors, glutamate transporters and ICl(Ca.

  12. Analog Experiment for rootless cone eruption (United States)

    Noguchi, R.; Hamada, A.; Suzuki, A.; Kurita, K.


    Rootless cone is a unique geomorphological landmark to specify igneous origin of investigated terrane, which is formed by magma-water interaction. To understand its formation mechanism we conducted analog experiment for heat-induced vesiculation by using hot syrup and sodium bicarbonate solution.

  13. Lagrangian duality and cone convexlike functions

    NARCIS (Netherlands)

    J.B.G. Frenk (Hans); G. Kassay


    textabstractIn this paper we will show that the closely K-convexlike vector-valued functions with K Rm a nonempty convex cone and related classes of vector-valued functions discussed in the literature arise naturally within the theory of biconjugate functions applied to the Lagrangian perturbation

  14. Sustainable Food & Sustainable Economics


    Alvarez, Mavis Dora


    Cuba today is immersed in a very intense process of perfecting its agricultural production structures with the goal of making them more efficient and sustainable in their economic administration and in their social and environmental management. Agricultural cooperatives in Cuba have the responsibility of producing on 73% of the country's farmland. Their contributions are decisive to developing agricultural production and to ensuring more and better food for the population, in addition to redu...

  15. Effects of the Cone and Edge on the Acoustic Characteristics of a Cone Loudspeaker

    Directory of Open Access Journals (Sweden)

    Yue Hu


    Full Text Available Loudspeakers are designed for reproducing the original sound field as faithfully as possible. In order to faithfully reproduce sound, it is important to understand the relationships among the physical characteristics of the loudspeaker. This paper focuses on the cone, the edge, and the behavior of air around the voice coil, which are important elements in the design of cone loudspeakers and evaluates their effects on the acoustic characteristics of the loudspeaker.

  16. Quantifying mechanical force in axonal growth and guidance

    National Research Council Canada - National Science Library

    Athamneh, Ahmad I M; Suter, Daniel M


    .... In particular, research has shown that force is involved in growth cone-mediated axonal growth and guidance as well as stretch-induced elongation when an organism increases in size after forming...

  17. Perturbation theory in light-cone quantization

    Energy Technology Data Exchange (ETDEWEB)

    Langnau, Alex [Stanford Univ., CA (United States)


    A thorough investigation of light-cone properties which are characteristic for higher dimensions is very important. The easiest way of addressing these issues is by analyzing the perturbative structure of light-cone field theories first. Perturbative studies cannot be substituted for an analysis of problems related to a nonperturbative approach. However, in order to lay down groundwork for upcoming nonperturbative studies, it is indispensable to validate the renormalization methods at the perturbative level, i.e., to gain control over the perturbative treatment first. A clear understanding of divergences in perturbation theory, as well as their numerical treatment, is a necessary first step towards formulating such a program. The first objective of this dissertation is to clarify this issue, at least in second and fourth-order in perturbation theory. The work in this dissertation can provide guidance for the choice of counterterms in Discrete Light-Cone Quantization or the Tamm-Dancoff approach. A second objective of this work is the study of light-cone perturbation theory as a competitive tool for conducting perturbative Feynman diagram calculations. Feynman perturbation theory has become the most practical tool for computing cross sections in high energy physics and other physical properties of field theory. Although this standard covariant method has been applied to a great range of problems, computations beyond one-loop corrections are very difficult. Because of the algebraic complexity of the Feynman calculations in higher-order perturbation theory, it is desirable to automatize Feynman diagram calculations so that algebraic manipulation programs can carry out almost the entire calculation. This thesis presents a step in this direction. The technique we are elaborating on here is known as light-cone perturbation theory.

  18. Genetic heterogeneity among blue-cone monochromats

    Energy Technology Data Exchange (ETDEWEB)

    Nathans, J.; Maumenee, I.H.; Zrenner, E.; Sadowski, B.; Sharpe, L.T.; Lewis, R.A.; Hansen, E.; Rosenberg, T.; Schwartz, M.; Heckenlively, J.R.; Traboulsi, E.; Klingaman, R.; Bech-Hansen, N.T.; LaRoche, G.R.; Pagon, R.A.; Murphey, W.H.; Weleber, R.G.


    Thirty-three unrelated subjects with blue-cone monochromacy or closely related variants of blue-cone monochromacy were examined for rearrangements in the tandem array of genes encoding the red- and green-cone pigments. In 24 subjects, eight genotypes were found that would be predicted to eliminate the function of all of the genes within the array. As observed in an earlier study, the rearrangements involve either deletion of a locus control region adjacent to the gene array or loss of function via homologous recombination and point mutation. One inactivating mutation, Cy[sup 203]-to-Arg, was found in 15 probands who carry single genes and in both visual pigment genes in one subject whose array has two genes. This mutation was also found in at least one of the visual pigment genes in one subject whose array has multiple genes and in 2 of 321 control subjects, suggesting that preexisting Cys[sup 203]-to-Arg mutations constitute a reservoir of chromosomes that are predisposed to generate blue-cone-monochromat genotypes by unequal homologous recombination and/or gene conversion. Two other point mutations were identified: (a) Arg[sup 247]-to-Ter in one subject with a single red-pigment gene and (b) Pro[sup 307]-to-Leu in one subject with a single 5[prime] red-3[prime] green hybrid gene. The observed heterogeneity of genotypes points to the existence of multiple one- and two-step mutational pathways to blue-cone monochromacy. 28 refs., 9 figs., 2 tabs.

  19. Sustaining and promoting professional growth

    DEFF Research Database (Denmark)

    Hilton, Annette; Hilton, Geoff

    The aim of this study is to design responsive and supportive interventions across a school to embed practice initiated through participation in a previous professional development program. An initial survey and focus group discussions were used to identify teachers' current understandings....... This is a two-year project. At this early stage, changes have been identified in cross-school curriculum planning to incorporate professional learning; classroom practices are being shared among researchers and teachers through modelled lessons and discussions; the school leadership team are supporting ongoing...

  20. Sustainability issues in civil engineering

    CERN Document Server

    Saride, Sireesh; Basha, B


    This compilation on sustainability issues in civil engineering comprises contributions from international experts who have been working in the area of sustainability in civil engineering. Many of the contributions have been presented as keynote lectures at the International Conference on Sustainable Civil Infrastructure (ICSCI) held in Hyderabad, India. The book has been divided into core themes of Sustainable Transportation Systems, Sustainable Geosystems, Sustainable Environmental and Water Resources and Sustainable Structural Systems. Use of sustainability principles in engineering has become an important component of the process of design and in this context, design and analysis approaches in civil engineering are being reexamined to incorporate the principles of sustainable designs and construction in practice. Developing economies are on the threshold of rapid infrastructure growth and there is a need to compile the developments in various branches of civil engineering and highlight the issues. It is th...

  1. On multivalued contractions in cone metric spaces without normality. (United States)

    Arshad, Muhammad; Ahmad, Jamshaid


    Wardowski (2011) in this paper for a normal cone metric space (X, d) and for the family A of subsets of X established a new cone metric H : A × A → E and obtained fixed point of set-valued contraction of Nadler type. Further, it is noticed in the work of Janković et al., 2011 that the fixed-point problem in the setting of cone metric spaces is appropriate only in the case when the underlying cone is nonnormal. In the present paper we improve Wardowski's result by proving the same without the assumption of normality on cones.

  2. R&D Towards Commercialization of Sea Wave Slot Cone Generator (SSG) Overtopping Wave Energy Converter

    DEFF Research Database (Denmark)

    Margheritini, Lucia

    between ventures and private investors, and to promote an accelerated shift from a technology to a market focus. This Thesis is presented as a collection of works published by the author on her research on the Sea wave Slot cone Generator wave energy converter. These include 1 accepted and 2 submitted...... from technology to market focus. This has been done by using the R&D steps for a specific wave energy converter as an example of best practice for wave energy development towards commercialization. The Sea wave Slot cone Generator (SSG) is a multilevel wave energy converter. Incoming waves overtop...... the consumption of fossil fuels and related greenhouse-gas emissions and to the development of Renewable Energy Sources (RES). Diversification of RES is fundamental in such a path to ensure sustainability. In this contest wave energy can provide great contribution, having its worldwide resource been estimated...

  3. Dual energy approach for cone beam artifacts correction (United States)

    Han, Chulhee; Choi, Shinkook; Lee, Changwoo; Baek, Jongduk


    Cone beam computed tomography systems generate 3D volumetric images, which provide further morphological information compared to radiography and tomosynthesis systems. However, reconstructed images by FDK algorithm contain cone beam artifacts when a cone angle is large. To reduce the cone beam artifacts, two-pass algorithm has been proposed. The two-pass algorithm considers the cone beam artifacts are mainly caused by high density materials, and proposes an effective method to estimate error images (i.e., cone beam artifacts images) by the high density materials. While this approach is simple and effective with a small cone angle (i.e., 5 - 7 degree), the correction performance is degraded as the cone angle increases. In this work, we propose a new method to reduce the cone beam artifacts using a dual energy technique. The basic idea of the proposed method is to estimate the error images generated by the high density materials more reliably. To do this, projection data of the high density materials are extracted from dual energy CT projection data using a material decomposition technique, and then reconstructed by iterative reconstruction using total-variation regularization. The reconstructed high density materials are used to estimate the error images from the original FDK images. The performance of the proposed method is compared with the two-pass algorithm using root mean square errors. The results show that the proposed method reduces the cone beam artifacts more effectively, especially with a large cone angle.

  4. What Do We Know about Risk Factors for Fetal Growth Restriction in Africa at the Time of Sustainable Development Goals? A Scoping Review. (United States)

    Accrombessi, Manfred; Zeitlin, Jennifer; Massougbodji, Achille; Cot, Michel; Briand, Valérie


    The reduction in the under-5 year mortality rate to at least as low as 25 per 1000 livebirths by 2030 has been implemented as one of the new Sustainable Development Goals. Fetal growth restriction (FGR) is one of the most important determinants of infant mortality in developing countries. In this review, we assess the extent of the literature and summarize its findings on the main preventable factors of FGR in Africa. A scoping review was conducted using the Arksey and O'Malley framework. Five bibliographic databases and grey literature were used to identify studies assessing at least one risk factor for FGR. Aggregate risk estimates for the main factors associated with FGR were calculated. Forty-five of a total of 671 articles were selected for the review. The prevalence of FGR varied between 2.6 and 59.2% according to both the African region and the definition of FGR. The main preventable factors reported were a low maternal nutritional status (aggrerate odds ratio [OR]: 2.28, 95% confidence interval [CI] 1.59, 3.25), HIV infection (aOR 1.86, 95% CI 1.38, 2.50), malaria (aOR 1.95, 95% CI 1.04, 3.66), and gestational hypertension (aOR 2.61, 95% CI 2.42, 2.82). FGR is, to a large extent, preventable through existing efficacious interventions dedicated to malaria, HIV and nutrition. Further studies are still needed to assess the influence of risk factors most commonly documented in high-income countries. Improving research on FGR in Africa requires a consensual and standardized definition of FGR-for a higher comparability-between studies and settings. © 2017 John Wiley & Sons Ltd.

  5. Cone damage in patients receiving high-dose irofulven treatment. (United States)

    Lee, Michael S; Gupta, Nisha; Penson, Richard T; Loewenstein, John; Wepner, Meredith S; Seiden, Michael V; Milam, Ann H


    To describe the clinical, perimetric, and electroretinographic (ERG) results of 4 patients with cone dysfunction following irofulven treatment including the histopathologic and immunocytochemical features of one patient's retinas. Observational case series. The patients were examined clinically, including perimetric and ERG evaluations. Eyes from patient 1 and healthy postmortem eyes were processed for histopathologic and immunocytochemistry studies with antibodies specific for cones, rods, and reactive Müller cells. Clinical signs and symptoms, perimetry, ERG, retinal histopathologic and immunocytochemistry study results. All 4 patients had ERG changes consistent with abnormal cone responses and relatively normal rod responses. Compared with control eyes, the retina of patient 1 had approximately half the normal numbers of macular cones and fewer peripheral cones. The number of rods were normal but all rod and cone outer segments were shortened. High-dose irofulven treatment causes cone-specific damage with relative sparing of rods.

  6. Dirac cones in two-dimensional borane (United States)

    Martinez-Canales, Miguel; Galeev, Timur R.; Boldyrev, Alexander I.; Pickard, Chris J.


    We introduce two-dimensional borane, a single-layered material of BH stoichiometry, with promising electronic properties. We show that, according to density functional theory calculations, two-dimensional borane is semimetallic, with two symmetry-related Dirac cones meeting right at the Fermi energy Ef. The curvature of the cones is lower than in graphene, thus closer to the ideal linear dispersion. Its structure, formed by a puckered trigonal boron network with hydrogen atoms connected to each boron atom, can be understood as distorted, hydrogenated borophene [Mannix et al., Science 350, 1513 (2015), 10.1126/science.aad1080]. Chemical bonding analysis reveals the boron layer in the network being bound by delocalized four-center two-electron σ bonds. Finally, we suggest high pressure could be a feasible route to synthesize two-dimensional borane.

  7. Lessons from the light-cone box

    CERN Document Server

    Leibbrandt, G


    Working in the noncovariant light-cone gauge, we discuss the explicit computation of the 1PI four-point function ("box diagram") in Yang- Mills theory. The complete box diagram which consists of 16 box subdiagrams, 8 lynx subdiagrams and 4 fish subdiagrams, yields both local and nonlocal UV divergent terms. The nonlocal terms are consistent with gauge symmetry and correspond to a nonlocal renormalization of the wave function. (14 refs).

  8. Wide-Field Fundus Autofluorescence for Retinitis Pigmentosa and Cone/Cone-Rod Dystrophy. (United States)

    Oishi, Akio; Oishi, Maho; Ogino, Ken; Morooka, Satoshi; Yoshimura, Nagahisa


    Retinitis pigmentosa and cone/cone-rod dystrophy are inherited retinal diseases characterized by the progressive loss of rod and/or cone photoreceptors. To evaluate the status of rod/cone photoreceptors and visual function, visual acuity and visual field tests, electroretinogram, and optical coherence tomography are typically used. In addition to these examinations, fundus autofluorescence (FAF) has recently garnered attention. FAF visualizes the intrinsic fluorescent material in the retina, which is mainly lipofuscin contained within the retinal pigment epithelium. While conventional devices offer limited viewing angles in FAF, the recently developed Optos machine enables recording of wide-field FAF. With wide-field analysis, an association between abnormal FAF areas and visual function was demonstrated in retinitis pigmentosa and cone-rod dystrophy. In addition, the presence of "patchy" hypoautofluorescent areas was found to be correlated with symptom duration. Although physicians should be cautious when interpreting wide-field FAF results because the peripheral parts of the image are magnified significantly, this examination method provides previously unavailable information.

  9. The NLO jet vertex in the small-cone approximation for kt and cone algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Colferai, D.; Niccoli, A. [Dipartimento di Fisica e Astronomia, Università di Firenze and INFN, Sezione di Firenze, 50019 Sesto Fiorentino (Italy)


    We determine the jet vertex for Mueller-Navelet jets and forward jets in the small-cone approximation for two particular choices of jet algoritms: the kt algorithm and the cone algorithm. These choices are motivated by the extensive use of such algorithms in the phenomenology of jets. The differences with the original calculations of the small-cone jet vertex by Ivanov and Papa, which is found to be equivalent to a formerly algorithm proposed by Furman, are shown at both analytic and numerical level, and turn out to be sizeable. A detailed numerical study of the error introduced by the small-cone approximation is also presented, for various observables of phenomenological interest. For values of the jet “radius” R=0.5, the use of the small-cone approximation amounts to an error of about 5% at the level of cross section, while it reduces to less than 2% for ratios of distributions such as those involved in the measure of the azimuthal decorrelation of dijets.

  10. A Coning Theory of Bullet Motions

    CERN Document Server

    Boatright, James A


    Each observable ballistic phenomenon of a spin-stabilized rifle bullet can be explained in terms of the acceleration of gravity and the total aerodynamic force acting on that bullet. In addition to the coning motion itself, Coning Theory explains the spinning bullet's aerodynamic jump and its steadily increasing yaw of repose together with its resulting spin-drift. The total aerodynamic force on the bullet comprises its drag and lift rectangular components and produces an associated overturning moment acting upon the rigid bullet. The coning motion of the bullet includes two distinct but synchronized aspects: 1) the well-known gyroscopic precession of the spin-axis of the bullet, and 2) the previously little-known orbiting of the center of gravity of the bullet around its mean trajectory with the nose of the bullet angled inward toward that trajectory. New equations are developed governing the orbital motion of the CG as a circular, isotropic harmonic oscillation driven by the lift and drag forces as they rev...

  11. Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growth factor-1 resulting in elevated sustainable insulin-like growth factor-1 and insulin-like growth factor binding protein 3 plasma levels: a case report

    Directory of Open Access Journals (Sweden)

    Madigan Margaret


    Full Text Available Abstract Introduction Adult Growth hormone Deficiency is a well known phenomenon effecting both males and females. Adult Growth Hormone Deficiency is marked by a number of neuropsychiatric, cognitive performance, cardiac, metabolic, muscular, and bone symptoms and clinical features. There is no known standardized acceptable therapeutic modality to treat this condition. A recent meta-analysis found that after 16 years of Growth Hormone replacement therapy a large proportion of the patients still had Growth Hormone associated symptoms especially related to executive functioning. A major goal is to increase plasma levels of both insulin-like growth factor (insulin-like growth factor-1 and insulin-like growth factor binding protein 3. Case Presentation We report a case of a 45-year-old caucasian woman with early ovarian failure for 2 years and amenorrhea since the age of 43, who presented with Adult Growth Hormone Deficiency and an IGF-1 of 126 ng/mL. Since her insulin-like growth factor-1 was lowest at 81 ng/mL, she was started on insulin-like growth factor-1 Increlex at 0.2 mg at bedtime, which immediately raised her insulin-like growth factor-1 levels to 130 ng/mL within 1 month, and 193 ng/mL, 249 ng/mL, and 357 ng/mL, after 3, 4, and 5 months, respectively, thereafter. Her insulin-like growth factor binding protein 3 continued to decrease. It was at this point when we added back the Growth Hormone and increased her Increlex dosage to 1.3 - 1.5 mg that her insulin-like growth factor binding protein 3 began to increase. Conclusion It appears that in some patients with Adult Growth Hormone Deficiency, insulin-like growth factor-1 elevation is resistant to direct Growth Hormone treatment. Furthermore, the binding protein may not rise with insulin-like growth factor-1. However, a combination of Growth Hormone and insulin-like growth factor-1 treatment may be a solution.

  12. Sustained elevation of circulating growth and differentiation factor-15 and a dynamic imbalance in mediators of muscle homeostasis are associated with the development of acute muscle wasting following cardiac surgery. (United States)

    Bloch, Susannah A A; Lee, Jen Y; Wort, S John; Polkey, Michael I; Kemp, Paul R; Griffiths, Mark J D


    Acute muscle wasting in the critically ill is common and causes significant morbidity. In a novel human model of acute muscle wasting following cardiac surgery, known or potential circulating modulators of muscle mass--insulin-like growth factor-1, myostatin, and growth and differentiation factor-15--were measured over a week. It was hypothesized that patients who developed acute muscle wasting would show distinct patterns of change in these mediators. A prospective longitudinal observational study of high-risk elective cardiac surgical patients identifying, by ultrasound, those developing muscle wasting. Tertiary cardiothoracic referral center: Royal Brompton Hospital, London, UK. Forty-two patients undergoing elective high-risk cardiothoracic surgery. Circulating insulin-like growth factor-1, myostatin, and growth and differentiation factor-15 were assayed preoperatively and over the first week postoperatively. The ability of growth and differentiation factor-15 to cause muscle wasting in vitro was determined in C2C12 myotubes. Of the 42 patients, 23 (55%) developed quadriceps atrophy. There was an acute decrease in insulin-like growth factor-1 and unexpectedly myostatin, known mediators of muscle hypertrophy and atrophy, respectively. By contrast, plasma growth and differentiation factor-15 concentrations increased in all patients. This increase in growth and differentiation factor-15 was sustained at day 7 in those who developed muscle wasting (day 7 compared with baseline, p0.05). Insulin-like growth factor-1 did not recover in those who developed muscle wasting (day 7 compared with baseline, p0.05). Finally, we demonstrated that growth and differentiation factor-15 caused atrophy of myotubes in vitro. These data support the hypothesis that acute muscle loss occurs as a result of an imbalance between drivers of muscle atrophy and hypertrophy. Growth and differentiation factor-15 is a potential novel factor associated with muscle atrophy, which may become a

  13. Sustainable agriculture

    National Research Council Canada - National Science Library

    Lichtfouse, Eric


    ... : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : : 9 Part I CLIMATE CHANGE Soils and Sustainable Agriculture: A Review : : : : : : : : : : : : : : : : : : : : : : : : : : Rattan Lal 15 Soils and Food Sufficiency...

  14. Sustainable Marketing

    NARCIS (Netherlands)

    Dam, van Y.K.


    In this article, three different conceptions of sustainable marketing are discussed and compared. These different conceptions are referred to as social, green, and critical sustainable marketing. Social sustainable marketing follows the logic of demand-driven marketing management and places the

  15. Collective effects in tilted Weyl cones: Optical conductivity, polarization, and Coulomb interactions reshaping the cone (United States)

    Detassis, Fabrizio; Fritz, Lars; Grubinskas, Simonas


    Recently, the existence of Dirac/Weyl cones in three-dimensional systems has been demonstrated experimentally. While in high-energy physics the isotropy of the Dirac/Weyl cones is guaranteed by relativistic invariance, in condensed-matter systems corrections to this can occur, with one possible type being a tilt. In this paper, we study the effect of tilted Weyl cones in collective effects. We study both the optical conductivity as well as the polarization function. We also investigate the perturbative effect of long-range Coulomb interactions using a renormalization-group calculation. We find that the tilt is perturbatively renormalized towards zero and at low energies the system flows to an effectively untilted theory.

  16. Lipid composition - Sustainable aquafeeds for marine finfish: Effects of vegetable oil replacement feeds containing novel microalgal and fungal oils on growth performance of juvenile sablefish (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The concomitant replacement of fish meal and fish oil in carnivorous marine fish feeds by more sustainable terrestrial alternatives is problematic due to the limited...

  17. Chemical composition - Sustainable aquafeeds for marine finfish: Effects of vegetable oil replacement feeds containing novel microalgal and fungal oils on growth performance of juvenile sablefish (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The concomitant replacement of fish meal and fish oil in carnivorous marine fish feeds by more sustainable terrestrial alternatives is problematic due to the limited...

  18. The use of cone beam computed tomography for the assessment of trichorhinophalangeal syndrome, type I - a case report. (United States)

    Ghoneima, Ahmed; Sachdeva, Kanwar; Hartsfield, James; Weaver, David; Kula, Katherine


    Trichorhinophalangeal syndrome type I is a rare autosomal dominant disorder characterized by cone-shaped epiphysis, sparse fine hair, pear-shaped nose and variable growth retardation. The typical craniofacial features include thin upper lip, elongated philtrum, large outstanding ears, shortened posterior facial height associated with short mandibular ramus and reduced and superiorly deflected posterior cranial base. This report describes a 17-year-old male patient with trichorhinophalangeal syndrome type I and a detailed description of the craniofacial radiographic findings, including the use of cone beam computed tomography images for determination of the airway and temporomandibular joint discrepancies.

  19. Tantalum cones and bone defects in revision total knee arthroplasty. (United States)

    Boureau, F; Putman, S; Arnould, A; Dereudre, G; Migaud, H; Pasquier, G


    Management of bone loss is a major challenge in revision total knee arthroplasty (TKA). The development of preformed porous tantalum cones offers new possibilities, because they seem to have biological and mechanical qualities that facilitate osseointegration. Compared to the original procedure, when metaphyseal bone defects are too severe, a single tantalum cone may not be enough and we have developed a technique that could extend the indications for this cone in these cases. We used 2 cones to fill femoral bone defects in 7 patients. There were no complications due to wear of the tantalum cones. Radiological follow-up did show any migration or loosening. The short-term results confirm the interest of porous tantalum cones and suggest that they can be an alternative to allografts or megaprostheses in case of massive bone defects. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. Techniques for optimizing nanotips derived from frozen taylor cones (United States)

    Hirsch, Gregory


    Optimization techniques are disclosed for producing sharp and stable tips/nanotips relying on liquid Taylor cones created from electrically conductive materials with high melting points. A wire substrate of such a material with a preform end in the shape of a regular or concave cone, is first melted with a focused laser beam. Under the influence of a high positive potential, a Taylor cone in a liquid/molten state is formed at that end. The cone is then quenched upon cessation of the laser power, thus freezing the Taylor cone. The tip of the frozen Taylor cone is reheated by the laser to allow its precise localized melting and shaping. Tips thus obtained yield desirable end-forms suitable as electron field emission sources for a variety of applications. In-situ regeneration of the tip is readily accomplished. These tips can also be employed as regenerable bright ion sources using field ionization/desorption of introduced chemical species.


    Directory of Open Access Journals (Sweden)

    Dragan (Santamarian Oana Raluca


    Full Text Available This paper describes one of the major challenges of the future: the sustainable development of the society. Sustainability is now increasingly recognized as central to the growth of emerging market economies. For the banking sector, this represents both a demand for greater social and environmental responsibility as well as a new landscape of business opportunity. Several years ago, the main part of the banks did not consider the social and environmental problems relevant for their operations. Recently, the banks began to realize the major impact of the sustainable development over the way of ulterior development of the society and, implicitly over the way of creating of the banking value in the future. In this context, the development of a banking management system, based on sustainable principles represents one of the provocations of these days.Starting from literature in the sustainable banking management field in this paper are presented several relevant issues related to risk management in the context of sustainable banking financing: the need to implement the sustainable management principles in financial and banking industry; the role of banks in sustainable development of society; social and environmental risk management policies, events that have shaped the role of the banking sector in sustainable development; international standards regarding sustainable banking management such us: Equator Principles for sustainable investment projects’ financing or GRI principles for sustainable reporting. Furthermore, we developed a practical case study related to the implementation of sustainable banking management at Bank of America.

  2. Spatial Distribution of Wave Pressures on Seawave Slot-Cone Generator

    DEFF Research Database (Denmark)

    Vicinanza, Diego; Margheritini, Lucia; Frigaard, Peter


    This paper presents results on loading acting on an innovative caisson breakwater for electricity production. The work reported here is part of the European Union Sixth Framework programme priority 6.1 (Sustainable Energy System), contract 019831, titled "Full-scale demonstration of robust and high......-efficiency wave energy converter" (WAVESSG). Information on wave loadings acting on Wave Energy Convert (WEC) Seawave Slot-Cone Generator (SSG) exposed to extreme wave conditions are reported. The SSG concept is based on the principle of overtopping and storing the wave energy in several reservoirs placed one...

  3. Sustainability and the University (United States)

    Clough, G. Wayne; Chameau, Jean-Lou; Carmichael, Carol


    In this article, the authors state that one of the major challenges facing the human race is charting a course for the future that allows economic growth while protecting the fragile planet. The authors discuss the role that higher education must play to help create a vibrant economy and high quality of life, while sustaining natural resources.…

  4. The macroecology of sustainability (United States)

    Burger, Joseph R.; Allen, Craig D.; Brown, James H.; Burnside, William R.; Davidson, Ana D.; Fristoe, Trevor S.; Hamilton, Marcus J.; Mercado-Silva, Norman; Nekola, Jeffrey C.; Okie, Jordan G.; Zuo, Wenyun


    The discipline of sustainability science has emerged in response to concerns of natural and social scientists, policymakers, and lay people about whether the Earth can continue to support human population growth and economic prosperity. Yet, sustainability science has developed largely independently from and with little reference to key ecological principles that govern life on Earth. A macroecological perspective highlights three principles that should be integral to sustainability science: 1) physical conservation laws govern the flows of energy and materials between human systems and the environment, 2) smaller systems are connected by these flows to larger systems in which they are embedded, and 3) global constraints ultimately limit flows at smaller scales. Over the past few decades, decreasing per capita rates of consumption of petroleum, phosphate, agricultural land, fresh water, fish, and wood indicate that the growing human population has surpassed the capacity of the Earth to supply enough of these essential resources to sustain even the current population and level of socioeconomic development.

  5. The macroecology of sustainability. (United States)

    Burger, Joseph R; Allen, Craig D; Brown, James H; Burnside, William R; Davidson, Ana D; Fristoe, Trevor S; Hamilton, Marcus J; Mercado-Silva, Norman; Nekola, Jeffrey C; Okie, Jordan G; Zuo, Wenyun


    The discipline of sustainability science has emerged in response to concerns of natural and social scientists, policymakers, and lay people about whether the Earth can continue to support human population growth and economic prosperity. Yet, sustainability science has developed largely independently from and with little reference to key ecological principles that govern life on Earth. A macroecological perspective highlights three principles that should be integral to sustainability science: 1) physical conservation laws govern the flows of energy and materials between human systems and the environment, 2) smaller systems are connected by these flows to larger systems in which they are embedded, and 3) global constraints ultimately limit flows at smaller scales. Over the past few decades, decreasing per capita rates of consumption of petroleum, phosphate, agricultural land, fresh water, fish, and wood indicate that the growing human population has surpassed the capacity of the Earth to supply enough of these essential resources to sustain even the current population and level of socioeconomic development.

  6. The Shape of Color: Retinal Cones and Spectral Dispersion


    Medeiros, John A.; Medeiros, Nancy E.


    Why are the retinal color receptors cone-shaped? This is not a trivial question: the cone shape is evidently a universal feature of the color receptors while the achromatic rod receptors are always rod-shaped. What might be behind this dichotomy has not previously been explored in any meaningful way. We suggest here that the cone shape is not an incidental feature, but actually integral to cone function. We describe a waveguide mode cut-off effect that can physically separate light into its s...

  7. Ion beam focusing with cone optics for WDM experiments

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Jun, E-mail: [Department of Energy Sciences, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8502 (Japan); Kondo, Kotaro; Oguri, Yoshiyuki [Research Laboratory for Nuclear Reactors, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550 (Japan); Horioka, Kazuhiko [Department of Energy Sciences, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8502 (Japan)


    Beam focusing properties of cone optics were systematically investigated by Monte Carlo simulations under various combinations of beam and cone parameters. To optimize the cone optic design for accelerator-driven WDM experiments, the beam intensity gains after cone focusing were evaluated from the simulation results as functions of cone wall material and shape parameters such as taper angle and wall curvature. The uniformity of the cone-focused beam was also examined by considering not only various cone parameters but also the cases involving the misalignment of the cone optic. From the results, a parabolic gold cone was found to be the best choice at least for relatively light ions such as lithium having MeV energies. It is also found that although smaller taper angle improves the total beam transport efficiency in the optic, it brings more difficulties in the alignment of the optic because the alignment accuracy should be less than a half of the taper angle to obtain acceptable uniformity in the beam energy deposition on the target.

  8. Civic Education for Sustainable Development (United States)

    Ohlmeier, Bernhard


    Education for sustainable development (ESD) often fails to consider the political dimension. To address this gap, this paper focuses on a specific political approach to ESD. The model presented is derived from the four sustainable growth targets of German Development Policy. Instead of relying on a neo-classical or neo-liberal economic paradigm,…

  9. Cone visual pigments of aquatic mammals. (United States)

    Newman, Lucy A; Robinson, Phyllis R


    It has long been hypothesized that the visual systems of animals are evolutionarily adapted to their visual environment. The entrance many millions of years ago of mammals into the sea gave these new aquatic mammals completely novel visual surroundings with respect to light availability and predominant wavelengths. This study examines the cone opsins of marine mammals, hypothesizing, based on previous studies [Fasick et al. (1998) and Levenson & Dizon (2003)], that the deep-dwelling marine mammals would not have color vision because the pressure to maintain color vision in the dark monochromatic ocean environment has been relaxed. Short-wavelength-sensitive (SWS) and long-wavelength-sensitive (LWS) cone opsin genes from two orders (Cetacea and Sirenia) and an additional suborder (Pinnipedia) of aquatic mammals were amplified from genomic DNA (for SWS) and cDNA (for LWS) by PCR, cloned, and sequenced. All animals studied from the order Cetacea have SWS pseudogenes, whereas a representative from the order Sirenia has an intact SWS gene, for which the corresponding mRNA was found in the retina. One of the pinnipeds studied (harp seal) has an SWS pseudogene, while another species (harbor seal) appeared to have an intact SWS gene. However, no SWS cone opsin mRNA was found in the harbor seal retina, suggesting a promoter or splice site mutation preventing transcription of the gene. The LWS opsins from the different species were expressed in mammalian cells and reconstituted with the 11-cis-retinal chromophore in order to determine maximal absorption wavelengths (lambda(max)) for each. The deeper dwelling Cetacean species had blue shifted lambda(max) values compared to shallower-dwelling aquatic species. Taken together, these findings support the hypothesis that in the monochromatic oceanic habitat, the pressure to maintain color vision has been relaxed and mutations are retained in the SWS genes, resulting in pseudogenes. Additionally, LWS opsins are retained in the

  10. Flow Lines Under Perturbation within Section Cones

    DEFF Research Database (Denmark)

    Wisniewski, Rafal

    map from the closed unit interval with the natural partial order inherited from the order of the real numbers to the manifold with the partial order defined as above, which furthermore preserves the partial orders. We examine di-paths between two critical points of minimal and of maximal index up......We want to examine a closed smooth manifold together with a certain partial order: In the set of vector fields on , , we define a section cone - a convex subset of characterized by the property that if is a singular point for some vector field in then this is the case for all members of . We say...

  11. Sustainable Disruptions

    DEFF Research Database (Denmark)

    Friis, Silje Alberthe Kamille; Kjær, Lykke Bloch


    Since 2012 the Sustainable Disruptions (SD) project at the Laboratory for Sustainability at Design School Kolding (DK) has developed and tested a set of design thinking tools, specifically targeting the barriers to economically, socially, and environmentally sustainable business development....... The tools have been applied in practice in collaboration with 11 small and medium sized companies (SMEs). The study investigates these approaches to further understand how design thinking can contribute to sustainable transition in a business context. The study and the findings are relevant to organizations...... invested in the issue of sustainable business development, in particular the leaders and employees of SMEs, but also to design education seeking new ways to consciously handle and teach the complexity inherent in sustainable transformation. Findings indicate that the SD design thinking approach contributes...

  12. Development and Degeneration of Cone Bipolar Cells Are Independent of Cone Photoreceptors in a Mouse Model of Retinitis Pigmentosa (United States)

    Chen, Miao; Wang, Ke; Lin, Bin


    Retinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood. To explore these issues, we backcrossed a transgenic mouse expressing enhanced green fluorescent protein (EGFP) in one subset of cone bipolar cells (type 7) into rd1 mice, a classic mouse model of retinal degeneration, to examine the development and survival of cone bipolar cells in a background of retinal degeneration. Our data revealed that both the development and degeneration of cone bipolar cells are independent of the normal activity of cone photoreceptors. We found that type 7 cone bipolar cells achieved a uniform tiling of the retinal surface and developed normal dendritic and axonal arbors without the influence of cone photoreceptor innervation. On the other hand, degeneration of type 7 cone bipolar cells, contrary to our belief of central-to-peripheral progression, was spatially uniform across the retina independent of the spatiotemporal pattern of cone degeneration. The results have important implications for the design of more effective therapies to restore vision in retinal degeneration. PMID:22952865

  13. Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa.

    Directory of Open Access Journals (Sweden)

    Miao Chen

    Full Text Available Retinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood. To explore these issues, we backcrossed a transgenic mouse expressing enhanced green fluorescent protein (EGFP in one subset of cone bipolar cells (type 7 into rd1 mice, a classic mouse model of retinal degeneration, to examine the development and survival of cone bipolar cells in a background of retinal degeneration. Our data revealed that both the development and degeneration of cone bipolar cells are independent of the normal activity of cone photoreceptors. We found that type 7 cone bipolar cells achieved a uniform tiling of the retinal surface and developed normal dendritic and axonal arbors without the influence of cone photoreceptor innervation. On the other hand, degeneration of type 7 cone bipolar cells, contrary to our belief of central-to-peripheral progression, was spatially uniform across the retina independent of the spatiotemporal pattern of cone degeneration. The results have important implications for the design of more effective therapies to restore vision in retinal degeneration.

  14. Computational sustainability

    CERN Document Server

    Kersting, Kristian; Morik, Katharina


    The book at hand gives an overview of the state of the art research in Computational Sustainability as well as case studies of different application scenarios. This covers topics such as renewable energy supply, energy storage and e-mobility, efficiency in data centers and networks, sustainable food and water supply, sustainable health, industrial production and quality, etc. The book describes computational methods and possible application scenarios.

  15. Sustainable transformation

    DEFF Research Database (Denmark)

    Andersen, Nicolai Bo

    This paper is about sustainable transformation with a particular focus on listed buildings. It is based on the notion that sustainability is not just a question of energy conditions, but also about the building being robust. Robust architecture means that the building can be maintained and rebuilt...... theoretical lenses. It is proposed that three parameters concerning the ꞌtransformabilityꞌ of the building can contribute to a more nuanced understanding of sustainable transformation: technical aspects, programmatic requirements and narrative value. It is proposed that the concept of ꞌsustainable...

  16. The biocytin wide-field bipolar cell in the rabbit retina selectively contacts blue cones (United States)

    MacNeil, Margaret A.; Gaul, Paulette A.


    The biocytin wide-field bipolar cell in rabbit retina is a sparsely populated ON cone bipolar cell with a broad dendritic arbor that does not contact all cones in its dendritic field. The purpose of our study was to identify the cone types that this cell contacts. We identified the bipolar cells by selective uptake of biocytin, labeled the cones with peanut agglutinin and then used antibodies against blue cone opsin and red-green cone opsin to identify the individual cone types. The biocytin-labeled cells selectively contacted cones whose outer segments stained for blue cone opsin and avoided cones that did not. We conclude that the biocytin wide-field bipolar cell is an ON blue cone bipolar cell in the rabbit retina and is homologous to the blue cone bipolar cells that have been previously described in primate, mouse, and ground squirrel retinas. PMID:17990268

  17. Scatter corrections for cone beam optical CT

    Energy Technology Data Exchange (ETDEWEB)

    Olding, Tim; Holmes, Oliver [Department of Physics, Queen' s University (United Kingdom); Schreiner, L John [Medical Physics Department, Cancer Centre of Southeastern Ontario (Canada)], E-mail:


    Cone beam optical computed tomography (OptCT) employing the VISTA scanner (Modus Medical, London, ON) has been shown to have significant promise for fast, three dimensional imaging of polymer gel dosimeters. One distinct challenge with this approach arises from the combination of the cone beam geometry, a diffuse light source, and the scattering polymer gel media, which all contribute scatter signal that perturbs the accuracy of the scanner. Beam stop array (BSA), beam pass array (BPA) and anti-scatter polarizer correction methodologies have been employed to remove scatter signal from OptCT data. These approaches are investigated through the use of well-characterized phantom scattering solutions and irradiated polymer gel dosimeters. BSA corrected scatter solutions show good agreement in attenuation coefficient with the optically absorbing dye solutions, with considerable reduction of scatter-induced cupping artifact at high scattering concentrations. The application of BSA scatter corrections to a polymer gel dosimeter lead to an overall improvement in the number of pixel satisfying the (3%, 3mm) gamma value criteria from 7.8% to 0.15%.

  18. Background information on the estimation of short-term effects of the Energy Agreement for Sustainable Growth on renewable energy; Toelichting inschatting korte-termijneffecten Energieakkoord op hernieuwbare energie

    Energy Technology Data Exchange (ETDEWEB)

    Hekkenberg, M.; Londo, H.M.; Lensink, S.M. [ECN Beleidsstudies, Petten (Netherlands)


    On September 4, 2013, representatives of employers' associations, trade union federations, environmental organizations, the Dutch government and civil society have signed an Energy Agreement for Sustainable Growth. ECN and PBL have been asked to evaluate this agreement. This report gives background information on the evaluation of the measures aimed at improving energy efficiency in industry and agriculture [Dutch] Op 4 september 2013 is het 'Energieakkoord voor duurzame groei' getekend. ECN en PBL zijn gevraagd het akkoord te beoordelen en door te rekenen. Dit rapport dient als achtergronddocument bij de doorrekening van de maatregelen gericht op energiebesparing in de industrie en land- en tuinbouw.

  19. Insectos de cones y semillas de las coniferas de Mexico (United States)

    David Cibrián-Tovar; Bernard H. Ebel; Harry O. Yates; José Tulio Mhdez-Montiel


    The hosts, description, damage, life cycle, habits, and importance of 54 known cone and seed destroying insects attacking Mexican conifer trees are discussed. Distribution maps and color photos are provided. New species described are three species of Cydia (seedworm), four species of Dioryctria (coneworm), and four species of cone...

  20. Integrity of the cone photoreceptor mosaic in oligocone trichromacy

    DEFF Research Database (Denmark)

    Michaelides, Michel; Rha, Jungtae; Dees, Elise W


    Oligocone trichromacy (OT) is an unusual cone dysfunction syndrome characterized by reduced visual acuity, mild photophobia, reduced amplitude of the cone electroretinogram with normal rod responses, normal fundus appearance, and normal or near-normal color vision. It has been proposed...

  1. Advances in Valveless Piezoelectric Pump with Cone-shaped Tubes (United States)

    Zhang, Jian-Hui; Wang, Ying; Huang, Jun


    This paper reviews the development of valveless piezoelectric pump with cone-shaped tube chronologically, which have widely potential application in biomedicine and micro-electro-mechanical systems because of its novel principles and deduces the research direction in the future. Firstly, the history of valveless piezoelectric pumps with cone-shaped tubes is reviewed and these pumps are classified into the following types: single pump with solid structure or plane structure, and combined pump with parallel structure or series structure. Furthermore, the function of each type of cone-shaped tubes and pump structures are analyzed, and new directions of potential expansion of valveless piezoelectric pumps with cone-shaped tubes are summarized and deduced. The historical argument, which is provided by the literatures, that for a valveless piezoelectric pump with cone-shaped tubes, cone angle determines the flow resistance and the flow resistance determines the flow direction. The argument is discussed in the reviewed pumps one by one, and proved to be convincing. Finally, it is deduced that bionics is pivotal in the development of valveless piezoelectric pump with cone-shaped tubes from the perspective of evolution of biological structure. This paper summarizes the current valveless piezoelectric pumps with cone-shaped tubes and points out the future development, which may provide guidance for the research of piezoelectric actuators.

  2. Semi-Empirical Method Interpretation of Cone Penetration Test (CPT ...

    African Journals Online (AJOL)

    Cone Penetration Test (CPT) is a reliable technique for measuring subsurface soil friction, cohesion and bearing capacity for pile foundation. In some parts of the ... The approach is suitable because of the insensitivity of the mechanical cone penetrometer in measuring skin friction, especially in clay deposits. Discovery and ...

  3. Sustainable Transportation

    DEFF Research Database (Denmark)

    Hall, Ralph P.; Gudmundsson, Henrik; Marsden, Greg


    that relate to the construction and maintenance of transportation infrastructure and the operation or use of the different transportation modes. The concept of sustainable transportation emerged in response to these concerns as part of the broader notion of sustainable development. Given the transportation...

  4. Sustaining dairy

    NARCIS (Netherlands)

    Villarreal Herrera, Georgina


    Dairy in Europe has undergone many changes in the last few years—the abolition of milk production quotas being a fundamental one. This study explores these changes in relation to the sustained social and environmental viability of the sector and how dairy processors' sustainability

  5. Sustainable Universities

    DEFF Research Database (Denmark)

    Grindsted, Thomas Skou


    . Declarations tend to have impact on three trends. Firstly, there is emerging international consensus on the university’s role and function in relation to sustainable development; secondly, the emergence of national legislation, and thirdly, an emerging international competition to be leader in sustainable...... campus performance....

  6. Sustainable Transition

    DEFF Research Database (Denmark)

    Hansen, Ole Erik; Søndergård, Bent


    of agendas/vision, technologies, actors and institutions in the emergent design of an urban mobility system based on an electric car sharing system. Why. Designing for sustainability is a fundamental challenge for future design practices; designers have to obtain an ability to contribute to sustainable...

  7. Sustainable Learning (United States)

    Cadwell, Louise; Dillon, Robert


    Green schools have moved into a new era that focuses on building a culture of sustainability in every aspect of learning in schools. In the early stages of sustainability education, the focus was on recycling and turning off the lights. Now, students and adults together are moving into the areas of advocacy and action that are based on a deep…

  8. Coaxial Electrospray of Ranibizumab-Loaded Microparticles for Sustained Release of Anti-VEGF Therapies.

    Directory of Open Access Journals (Sweden)

    Leilei Zhang

    Full Text Available Age-related macular degeneration (AMD is the leading cause of vision loss and blindness in people over age 65 in industrialized nations. Intravitreous injection of anti-VEGF (vascular endothelial growth factor therapies, such as ranibizumab (trade name: Lucentis, provides an effective treatment option for neovascular AMD. We have developed an improved coaxial electrospray (CES process to encapsulate ranibizumab in poly(lactic-co-glycolic acid (PLGA microparticles (MPs for intravitreous injection and sustained drug release. This microencapsulation process is advantageous for maintaining the stability of the coaxial cone-jet configurations and producing drug-loaded MPs with as high as 70% encapsulation rate and minimal loss of bioactivitiy. The utility of this emerging process in intravitreous drug delivery has been demonstrated in both benchtop and in vivo experiments. The benchtop test simulates ocular drug release using PLGA MPs encapsulating a model drug. The in vivo experiment evaluates the inflammation and retinal cell death after intravitreal injection of the MPs in a chick model. The experimental results show that the drug-load MPs are able to facilitate sustained drug release for longer than one month. No significant long term microglia reaction or cell death is observed after intravitreal injection of 200 μg MPs. The present study demonstrates the technical feasibility of using the improved CES process to encapsulate water-soluble drugs at a high concentration for sustained release of anti-VEGF therapy.

  9. Topologies on superspaces of TVS-cone metric spaces. (United States)

    Ge, Xun; Lin, Shou


    This paper investigates superspaces 0(X) and 0(X) of a tvs-cone metric space (X, d), where 0(X) and 0(X) are the space consisting of nonempty subsets of X and the space consisting of nonempty compact subsets of X, respectively. The purpose of this paper is to establish some relationships between the lower topology and the lower tvs-cone hemimetric topology (resp., the upper topology and the upper tvs-cone hemimetric topology to the Vietoris topology and the Hausdorff tvs-cone hemimetric topology) on 0(X) and 0(X), which makes it possible to generalize some results of superspaces from metric spaces to tvs-cone metric spaces.

  10. 'Parabolic' trapped modes and steered Dirac cones in platonic crystals. (United States)

    McPhedran, R C; Movchan, A B; Movchan, N V; Brun, M; Smith, M J A


    This paper discusses the properties of flexural waves governed by the biharmonic operator, and propagating in a thin plate pinned at doubly periodic sets of points. The emphases are on the design of dispersion surfaces having the Dirac cone topology, and on the related topic of trapped modes in plates for a finite set (cluster) of pinned points. The Dirac cone topologies we exhibit have at least two cones touching at a point in the reciprocal lattice, augmented by another band passing through the point. We show that these Dirac cones can be steered along symmetry lines in the Brillouin zone by varying the aspect ratio of rectangular lattices of pins, and that, as the cones are moved, the involved band surfaces tilt. We link Dirac points with a parabolic profile in their neighbourhood, and the characteristic of this parabolic profile decides the direction of propagation of the trapped mode in finite clusters.

  11. The cone penetration test in unsaturated silty sands

    Directory of Open Access Journals (Sweden)

    Yang Hongwei


    Full Text Available Very little is known about how to interpret the cone penetration test (CPT when performed in unsaturated soils. The few published studies on the CPT in unsaturated soils have focused on either clean sands or a silt. In this study new results of laboratory-controlled CPTs in an unsaturated silty sand are presented. The silty sand exhibits hydraulic hysteresis and suction hardening. Suction is observed to have a pronounced affect on measured cone penetration resistance. For an isotropic net confining stress of 60 kPa it is observed that higher suctions give rise to cone penetration resistances that are 50% larger than those for lower suctions. A semi-theoretical correlation is presented that links measured cone penetration resistances to initial relative density and mean effective stress. For this silty sand it is shown that failing to account for suction may result in significant overestimations and unsafe predictions of soil properties from measured cone penetration resistances.

  12. Hypersonic boundary-layer transition measurements at Mach 10 on a large seven-degree cone at angle of attack (United States)

    Moraru, Ciprian G.

    The ability to predict the onset of boundary-layer transition is critical for hypersonic flight vehicles. The development of prediction methods depends on a thorough comprehension of the mechanisms that cause transition. In order to improve the understanding of hypersonic boundary-layer transition, tests were conducted on a large 7° half-angle cone at Mach 10 in the Arnold Engineering Development Complex Wind Tunnel 9. Twenty-four runs were performed at varying unit Reynolds numbers and angles of attack for sharp and blunt nosetip configurations. Heat-transfer measurements were used to determine the start of transition on the cone. Increasing the unit Reynolds number caused a forward movement of transition on the sharp cone at zero angle of attack. Increasing nosetip radius delayed transition up to a radius of 12.7 mm. Larger nose radii caused the start of transition to move forward. At angles of attack up to 10°, transition was leeside forward for nose radii up to 12.7 mm and windside forward for nose radii of 25.4 mm and 50.8 mm. Second-mode instability waves were measured on the sharp cone and cones with small nose radii. At zero angle of attack, waves at a particular streamwise location on the sharp cone were in earlier stages of development as the unit Reynolds number was decreased. The same trend was observed as the nosetip radius was increased. No second-mode waves were apparent for the cones with large nosetip radii. As the angle of attack was increased, waves at a particular streamwise location on the sharp cone moved to earlier stages of growth on the windward ray and later stages of growth on the leeward ray. RMS amplitudes of second-mode waves were computed. Comparison between maximum second-mode amplitudes and edge Mach numbers showed good correlation for various nosetip radii and unit Reynolds numbers. Using the e N method, initial amplitudes were estimated and compared to freestream noise in the second-mode frequency band. Correlations indicate

  13. Seed cone anatomy of Cheirolepidiaceae (Coniferales): reinterpreting Pararaucaria patagonica Wieland. (United States)

    Escapa, Ignacio H; Rothwell, Gar W; Stockey, Ruth A; Cúneo, N Rubén


    Seed cone morphology and anatomy reflect some of the most important changes in the phylogeny and evolutionary biology of conifers. Reexamination of the enigmatic Jurassic seed cone Pararaucaria patagonica reveals previously unknown systematically informative characters that demonstrate affinities with the Cheirolepidiaceae. This paper documents, for the first time, internal anatomy for seed cones of this important extinct Mesozoic conifer family, which may represent the ghost lineage leading to modern Pinaceae. Morphology and anatomy of cones from the Jurassic La Matilde Formation in Patagonia are described from a combination of polished wafers and thin section preparations. New photographic techniques are employed to reveal histological details of thin sections in which organic cell wall remains are not preserved. Specific terminology for conifer seed cones is proposed to help clarify hypotheses of homology for the various structures of the cones. Specimens are demonstrated to have trilobed ovuliferous scale tips along with a seed enclosing pocket of ovuliferous scale tissue. Originally thought to represent a seed wing in P. patagonica, this pocket-forming tissue is comparable to the flap of tissue covering seeds of compressed cheirolepidiaceous cones and is probably the most diagnostic character for seed cones of the family. Pararaucaria patagonica is assigned to Cheirolepidiaceae, documenting anatomical features for seed cones of the family and providing evidence for the antiquity of pinoid conifers leading to the origin of Pinaceae. A list of key morphological and anatomical characters for seed cones of Cheirolepidiaceae is developed to facilitate assignment of a much broader range of fossil remains to the family. This confirms the presence of Cheirolepidiaceae in the Jurassic of the Southern Hemisphere, which was previously suspected from palynological records.

  14. Biocytin wide-field bipolar cells in rabbit retina selectively contact blue cones. (United States)

    MacNeil, Margaret A; Gaul, Paulette A


    The biocytin wide-field bipolar cell in rabbit retina has a broad axonal arbor in layer 5 of the inner plexiform layer and a wide dendritic arbor that does not contact all cones in its dendritic field. The purpose of our study was to identify the types of cones that this cell contacts. We identified the bipolar cells by selective uptake of biocytin, labeled the cones with peanut agglutinin, and then used antibodies against blue cone opsin and red-green cone opsin to identify the individual cone types. The biocytin-labeled cells selectively contacted cones whose outer segments stained for blue cone opsin and avoided cones that did not. We conclude that the biocytin wide-field bipolar cell is an ON blue cone bipolar cell in the rabbit retina and is homologous to the blue cone bipolar cells that have been previously described in primate, mouse, and ground squirrel retinas. Copyright 2007 Wiley-Liss, Inc.

  15. Cone beam computed tomography in endodontic

    Energy Technology Data Exchange (ETDEWEB)

    Durack, Conor; Patel, Shanon, E-mail: [Unit of Endodontology, Department of Conservative Dentistry, King' s College London, London (United Kingdom)


    Cone beam computed tomography (CBCT) is a contemporary, radiological imaging system designed specifically for use on the maxillofacial skeleton. The system overcomes many of the limitations of conventional radiography by producing undistorted, three-dimensional images of the area under examination. These properties make this form of imaging particularly suitable for use in endodontic. The clinician can obtain an enhanced appreciation of the anatomy being assessed, leading to an improvement in the detection of endodontic disease and resulting in more effective treatment planning. In addition, CBCT operates with a significantly lower effective radiation dose when compared with conventional computed tomography (CT). The purpose of this paper is to review the current literature relating to the limitations and potential applications of CBCT in endodontic practice. (author)

  16. Numerical Aspects of Cone Beam Contour Reconstruction (United States)

    Louis, Alfred K.


    We describe a method for directly calculating the contours of a function from cone beam data. The algorithm is based on a new inversion formula for the gradient of a function presented in Louis (Inverse Probl 32(11):115005, 2016. The Radon transform of the gradient is found by using a Grangeat type of formula, reducing the inversion problem to the inversion of the Radon transform. In that way the influence of the scanning curve, vital for all exact inversion formulas for complete data, is avoided Numerical results are presented for the circular scanning geometry which neither fulfills the Tuy-Kirillov condition nor the much weaker condition given by the author in Louis (Inverse Probl 32(11):115005, 2016.

  17. Nearest-neighbor analysis of small features on Mars: Applications to tumuli and rootless cones (United States)

    Baloga, S. M.; Glaze, L. S.; Bruno, B. C.


    Fields of low relief cones, domes, and mounds on Mars have been interpreted as tumuli, rootless cones, and pingos. The spatial distribution of such features can be characterized by their nearest-neighbor (NN) distances. The NN distributions can provide insight into the physical processes that affected field formation and can possibly provide a future diagnostic of the feature type present on Mars. The conventional approach for analyzing the observed NN distribution is based on the Poisson probability distribution and uses one statistic, c. Our simulations of spatial randomness show that there is an unrecognized bias in c that often leads to erroneous conclusions. Three alternative extensions of the Poisson distribution are proposed here. The first accounts for a minimum threshold on the size of features discerned, the second considers the scavenging of the resources necessary to form neighboring features (e.g., inflation pressurization and subsurface volatiles), and the third models self-limiting growth of the feature population. Three statistical tests are proposed to improve the conventional NN analysis. We provide the critical regions needed to perform these tests for common sample sizes of these geologic features. Our methodology is applied to tumuli at Mauna Ulu, Hawaii, and conjectured tumuli and rootless cones on Mars. Each example exhibits a different aspect of spatial randomness. These applications suggest avenues for further field and theoretical studies to develop this approach as a remote-sensing diagnostic.

  18. Sustainable consumption

    DEFF Research Database (Denmark)

    Prothero, Andrea; Dobscha, Susan; Freund, Jim


    This essay explores sustainable consumption and considers possible roles for marketing and consumer researchers and public policy makers in addressing the many sustainability challenges that pervade our planet. Future research approaches to this interdisciplinary topic need to be comprehensive...... and systematic and will benefit from a variety of different perspectives. There are a number of opportunities for future research, and three areas are explored in detail. First, the essay considers the inconsistency between the attitudes and behaviors of consumers with respect to sustainability; next, the agenda...... is broadened to explore the role of individual citizens in society; and finally, a macro institutional approach to fostering sustainability is explored. Each of these areas is examined in detail and possible research avenues and public policy initiatives are considered within each of these separate...

  19. Sustainability reporting

    NARCIS (Netherlands)

    Kolk, A.


    This article gives an overview of developments in sustainability (also sometimes labelled corporate social responsibility) reporting. The article will first briefly indicate how accountability on social and environmental issues started, already in the 1970s when social reports were published.

  20. Sustainable Cities

    DEFF Research Database (Denmark)

    Georg, Susse; Garza de Linde, Gabriela Lucía

    Judging from the number of communities and cities striving or claiming to be sustainable and how often eco-development is invoked as the means for urban regeneration, it appears that sustainable and eco-development have become “the leading paradigm within urban development” (Whitehead 2003......), urban design competitions are understudied mechanisms for bringing about field level changes. Drawing on actor network theory, this paper examines how urban design competitions may bring about changes within the professional field through the use of intermediaries such as a sustainable planning....../assessment tool. The context for our study is urban regeneration in one Danish city, which had been suffering from industrial decline and which is currently investing in establishing a “sustainable city”. Based on this case study we explore how the insights and inspiration evoked in working with the tool...

  1. Sustainable responsibilities?

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang


    This working paper analyzes the conceptions of corporate responsibility for sustainable development in EU policies on CSR. The notion of corporate responsibility has until recently been limited to economical and legal responsibilities. Based on this narrow conception of corporate responsibility.......e. a combination of destruction and construction, this chapter will deconstruct conceptions of responsibility for sustainable development in these EU documents on CSR. A deconstructive conceptual analysis involves destructing dominant interpretations of a text and allowing for constructions of alternative...... such as sustainability actually means, but on what the concept says and does not say. A deconstructive analysis of EU policies on CSR, then, pinpoints that such policies are sites of conceptual struggles. This kind of analysis is suitable for studying conceptions of corporate responsibility for sustainable development...

  2. Agriculture: Sustainability (United States)

    Sustainability creates and maintains the conditions under which humans and nature can exist in productive harmony, that permit fulfilling the food, feed, and fiber needs of our country and the social, economic and other requirements.

  3. Sustainable School Leadership: The Teachers' Perspective (United States)

    Cook, John W.


    Sustainable school leadership is essential to the academic growth of students and professional growth of faculty and staff. Shedding light on what constitutes sustainable leadership from the perspective of teachers will increase our understanding of how specific leadership practices and processes impact those in the learning community who are…

  4. Sustainable finance


    Boersma-de Jong, Margreet F.


    Presentation for Springschool of Strategy, University of Groningen, 10 October 2012. The role of CSR is to stimulate ethical behaviour, and as a result, mutual trust in society. Advantage of CSR for the company and the evolution of CSR. From CSR to Sustainable Finance: how does CSR influence Sustainable Business Administration & Management Accounting, Financial Leadership and what is the importance of CSR in the financial sector

  5. Cadmium Removal from Aqueous Solutions by Ground Pine Cone

    Directory of Open Access Journals (Sweden)

    H Izanloo, S Nasseri


    Full Text Available A study on the removal of cadmium ions from aqueous solutions by pine cone was conducted in batch conditions. Kinetic data and equilibrium removal isotherms were obtained. The influence of different experimental parameters such as contact time, initial concentration of cadmium, pine cone mass and particle size, and temperature on the kinetics of cadmium removal was studied. Results showed that the main parameters that played an important role in removal phenomenon were initial cadmium concentration, particle size and pine cone mass. The necessary time to reach equilibrium was between 4 and 7 hours based on the initial concentration of cadmium. The capacity of cadmium adsorption at equilibrium increased with the decrease of pine cone particle size. The capacity of cadmium adsorption at equilibrium by pine cone increased with the quantity of pine cone introduced (1–4 g/L. Temperature in the range of 20-30°C showed a restricted effect on the removal kinetics (13.56 mg/g at 20°C and a low capacity of adsorption about 11.48 mg/g at 30°C. The process followed pseudo second-order kinetics. The cadmium uptake of pine cone was quantitatively evaluated using adsorption isotherms. Results indicated that the Langmuir model gave a better fit to the experimental data in comparison with the Freundlich equation.


    Directory of Open Access Journals (Sweden)

    Linda STEG


    Full Text Available This paper discusses possible contributions of psychologists to sustainable transportation. It is argued that in order to reach sustainable transportation, among others, behaviour changes of individual car users are needed. As transport policies will be more effective if they target important antecedents of travel behaviour, first, factors influencing such behaviour are discussed. It is argued that car use is very attractive and sometimes even necessary for many different reasons. This implies that a combination of policies is called for, each targeting different factors that support car use and hinder the use of more sustainable modes of transport. Next, the paper elaborates on policy strategies that may be employed to achieve sustainable transportation by changing car use. Increasing the attractiveness of sustainable transport modes by means of pull measures seems not sufficient to reduce the level of car use. Besides, car use should be made less attractive by means of push measures to force drivers to reconsider their travel behaviour. The acceptability of such policies may be increased by clearly communicating the aim of these policies, and the expected positive consequences (e.g., less congestion, improved environmental quality. Moreover, possible negative effects for individual freedom may be compensated by implementing additional policies aimed at facilitating the use of sustainable transport modes.

  7. Sustainable markets for sustainable energy

    Energy Technology Data Exchange (ETDEWEB)

    Millan, J.; Smyser, C.


    The author discusses how the Inter-American Development Bank (IDB) is involved in sustainable energy development. It presently has 50 loans and grants for non conventional renewable energy projects and ten grants for efficiency programs for $600 and $17 million respectively, representing 100 MW of power. The IDB is concerned with how to create a sustainable market for sustainable energy projects. The IDB is trying to work with government, private sector, NGOs, trading allies, credit sources, and regulators to find proper roles for such projects. He discusses how the IDB is working to expand its vision and objectives in renewable energy projects in Central and South America.

  8. Stability of r-minimal cones in R (United States)

    Barros, A.; Sousa, P.


    The study of minimal cones C(M) in R construed over compact minimal hypersurface M of a unit Euclidean sphere Sn has an important link with the Bernstein problem, see e.g. Bombieri et al. [E. Bombieri, E. de Giorgi, E. Giusti, Minimal cones and Bernstein problem, Invent. Math. 7 (1969) 243-268]. It was studied by many authors with a remarkable paper due to Simmons [J. Simmons, Minimal varieties in Riemannian manifolds, Ann. of Math. 88 (1968) 62-105]. In a recent work Barbosa and Do Carmo [J.L.M. Barbosa, M.P. Do Carmo, On the stability of cones in R with zero scalar curvature, Ann. Global Anal. Geom. 28 (2005) 107-122] treated cones in R with the second function of curvature S2=0 and S3⁄=0. In these papers the authors showed the existence of a truncated cone which is unstable as well as truncated cones over Clifford tori that are stable. Here we partially extend such results for cones construed over compact hypersurfaces M of the unit sphere Sn with Sr=0 and S⁄=0 by showing that there exists ɛ>0 for which the truncated cone C( is (r-1)-unstable provided n≤r+5. Moreover, we also show that for n≥r+6 there exists a Clifford torus Sp(r1)×Sq(r2)⊂Sn with Sr=0 and S⁄=0, for which all truncated cones based on such a torus are (r-1)-stable.

  9. "Sustainability and Surplus"


    Haider A. Khan


    In this paper we present two new concepts for studying sustainability. The first is the idea of an environmentally adjusted surplus(ES). The classical concept of surplus is revised to approximate the total available discretionary income for the society under ordinary (capitalist) growth process.ES is an operationalizable concept. We demonstrate this here via a simplified but illustrative exercise. Work with large data sets employing social and environmental accounting will yield sharper and m...

  10. Alopecia associated with unexpected leakage from electron cone

    Energy Technology Data Exchange (ETDEWEB)

    Wen, B.C.; Pennington, E.C.; Hussey, D.H.; Jani, S.K.


    Excessive irradiation due to unexpected leakage was found on a patient receiving electron beam therapy. The cause of this leakage was analyzed and the amount of leakage was measured for different electron beam energies. The highest leakage occurred with a 6 x 6 cm cone using a 12 MeV electron beam. The leakage dose measured along the side of the cone could be as great as 40%. Until the cones are modified or redesigned, it is advised that all patient setups be carefully reviewed to assure that no significant patient areas are in the side scatter region.

  11. Light-cone averaging in cosmology: formalism and applications

    Energy Technology Data Exchange (ETDEWEB)

    Gasperini, M. [Dipartimento di Fisica, Università di Bari, Via G. Amendola 173, 70126 Bari, Italy, (Italy); Marozzi, G.; Veneziano, G. [Collège de France, 11 Place M. Berthelot, 75005 Paris (France); Nugier, F., E-mail:, E-mail:, E-mail:, E-mail: [Laboratoire de Physique Théorique de l' École Normale Supérieure, CNRS UMR 8549, 24 Rue Lhomond, 75005 Paris (France)


    We present a general gauge invariant formalism for defining cosmological averages that are relevant for observations based on light-like signals. Such averages involve either null hypersurfaces corresponding to a family of past light-cones or compact surfaces given by their intersection with timelike hypersurfaces. Generalized Buchert-Ehlers commutation rules for derivatives of these light-cone averages are given. After introducing some adapted ''geodesic light-cone'' coordinates, we give explicit expressions for averaging the redshift to luminosity-distance relation and the so-called ''redshift drift'' in a generic inhomogeneous Universe.

  12. An anticancer agent icaritin induces sustained activation of the extracellular signal regulated kinase (ERK) pathway and inhibits growth of breast cancer cells


    Guo, YuMing; Zhang, XinTian; Meng, Jun; Wang, Zhao-Yi


    Icaritin, a prenylflavonoid derivative from Epimedium Genus, regulates many cellular processes. However, the function and the underlying mechanisms of icaritin in breast cancer cell growth have not been well established. Here, we report that icaritin strongly inhibited growth of breast cancer MDA-MB-453 and MCF7 cells. At concentrations of 2–3μM, icaritin induced cell cycle arrest at the G2/M phase accompanied by a down-regulation of the expression levels of the G2/M regulatory proteins such ...

  13. History of imaging in orthodontics from Broadbent to cone-beam computed tomography. (United States)

    Hans, Mark G; Palomo, J Martin; Valiathan, Manish


    The history of imaging and orthodontics is a story of technology informing biology. Advances in imaging changed our thinking as our understanding of craniofacial growth and the impact of orthodontic treatment deepened. This article traces the history of imaging in orthodontics from the invention of the cephalometer by B. Holly Broadbent in 1930 to the introduction of low-cost, low-radiation-dose cone-beam computed tomography imaging in 2015. Copyright © 2015 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  14. The Traditional Peoples and the Myth of Economic Growth in Harmony with Sustainable Development : A Critique of Light Doctrine protectionist Environment

    Directory of Open Access Journals (Sweden)

    Carla Vladiane Alves Leite


    Full Text Available In recent years the impact of economic development on the natural environment intensified geometric way in a world of problematic context of resource depletion and devastation of the environment to acquire raw material, endangering the ecosystems that sustain all the dynamics of humanity, especially the indigenous peoples that inhabit these places. This reality is not new, having been the subject of discussion since the beginning of the last century. As a result, the complexity and urgency of environmental issues have led the global community to work together to establish a new perspective and new ways for the environmental sustainable development, which could do live in harmony the need to develop economically and socially But with the right to a healthy and environmentally protected life, since it is a fundamental right to human dignity, recognized worldwide. For this, new public policies are being implemented and many of the old are being re- vised. Given the importance of the issue that raises debate, this paper intends to make a study of the doctrinal considerations involved theme in the light of diffuse rights and the protection of traditional peoples. Therefore, it will be observed the evolution of the concept, his balls and doctrinal and legal perspectives front of an international protective legislation Environmental Law and traditional peoples.

  15. Treatment with highly active antiretroviral therapy in human immunodeficiency virus type 1-infected children is associated with a sustained effect on growth

    NARCIS (Netherlands)

    G. Verweel; N.G. Hartwig (Nico); H.J. Scherpbier; R. de Groot (Ronald); T.F.W. Wolfs (Tom); A.M.C. van Rossum (Annemarie)


    textabstractINTRODUCTION: Growth failure is a common feature of children with human immunodeficiency virus type 1 (HIV-1) infection. Children who are treated with mono or dual nucleoside analogue reverse transcriptase inhibitor (NRTI) therapy show a temporary increase in weight

  16. The biocytin wide-field bipolar cell in the rabbit retina selectively contacts blue cones


    MacNeil, Margaret A.; Gaul, Paulette A.


    The biocytin wide-field bipolar cell in rabbit retina is a sparsely populated ON cone bipolar cell with a broad dendritic arbor that does not contact all cones in its dendritic field. The purpose of our study was to identify the cone types that this cell contacts. We identified the bipolar cells by selective uptake of biocytin, labeled the cones with peanut agglutinin and then used antibodies against blue cone opsin and red-green cone opsin to identify the individual cone types. The biocytin-...

  17. Maxillary Transverse Comparison of Skeletal Class I and Class III Patient Populations Using Cone Beam Computed Tomography (United States)


    image. Establishing diagnostic problems in this plane can be critical even in the youngest of patients as cessation of the transverse growth comes...Williams CE. Control of the transverse dimension with surgery and orthodontics . Am J Orthod 1980;77:284-306 (NEED) 62     23. Lagravere MO...i     MAXILLARY TRANSVERSE COMPARISON OF SKELETAL CLASS I AND CLASS III PATIENT POPULATIONS USING CONE BEAM COMPUTED TOMOGRAPHY A

  18. Roundtabling Sustainability

    DEFF Research Database (Denmark)

    Ponte, Stefano


    The willingness of public authority to delegate social and environmental regulation to the private sector has varied from sector to sector, but has often led to the establishment of ‘voluntary’ standards and certifications on sustainability. Many of these have taken the form of ‘stewardship...... councils’ and ‘sustainability roundtables’ and have been designed around a set of institutional features seeking to establish legitimacy, fend off possible criticism, and ‘sell’ certifications to potential users. The concept of ‘roundtabling’ emphasizes the fitting a variety of commodity......-specific sustainability situations into a form that not only ‘hears more voices’ (as in ‘multi-stakeholder’), but also portrays to give them equal standing at the table of negotiations (roundtable), thus raising higher expectations on accountability, transparency and inclusiveness. In this article, I examine to what...

  19. Optimization of Cone Beam CT Reconstruction Algorithm Based on CUDA

    National Research Council Canada - National Science Library

    Wang Li-Fang; Zhang Shu-Hai


    .... This paper optimizes cone beam CT reconstruction algorithm by CUDA and improves the speed of weighted back-projection and filtering, and shortens the data access time by using the texture memory...

  20. Testing the reliability of ice-cream cone model (United States)

    Pan, Zonghao; Shen, Chenglong; Wang, Chuanbing; Liu, Kai; Xue, Xianghui; Wang, Yuming; Wang, Shui


    Coronal Mass Ejections (CME)'s properties are important to not only the physical scene itself but space-weather prediction. Several models (such as cone model, GCS model, and so on) have been raised to get rid of the projection effects within the properties observed by spacecraft. According to SOHO/ LASCO observations, we obtain the 'real' 3D parameters of all the FFHCMEs (front-side full halo Coronal Mass Ejections) within the 24th solar cycle till July 2012, by the ice-cream cone model. Considering that the method to obtain 3D parameters from the CME observations by multi-satellite and multi-angle has higher accuracy, we use the GCS model to obtain the real propagation parameters of these CMEs in 3D space and compare the results with which by ice-cream cone model. Then we could discuss the reliability of the ice-cream cone model.

  1. New fixed and periodic point results on cone metric spaces

    Directory of Open Access Journals (Sweden)

    Ghasem Soleimani Rad


    Full Text Available In this paper, several xed point theorems for T-contraction of two maps on cone metric spaces under normality condition are proved. Obtained results extend and generalize well-known comparable results in the literature.

  2. CNGA3 Mutations in Hereditary Cone Photoreceptor Disorders

    National Research Council Canada - National Science Library

    Wissinger, Bernd; Gamer, Daphne; Jägle, Herbert; Giorda, Roberto; Marx, Tim; Mayer, Simone; Tippmann, Sabine; Broghammer, Martina; Jurklies, Bernhard; Rosenberg, Thomas; Jacobson, Samuel G; Sener, E. Cumhur; Tatlipinar, Sinan; Hoyng, Carel B; Castellan, Claudio; Bitoun, Pierre; Andreasson, Sten; Rudolph, Günter; Kellner, Ulrich; Lorenz, Birgit; Wolff, Gerhard; Verellen-Dumoulin, Christine; Schwartz, Marianne; Cremers, Frans P.M; Apfelstedt-Sylla, Eckart; Zrenner, Eberhart; Salati, Roberto; Sharpe, Lindsay T; Kohl, Susanne


    We recently showed that mutations in the CNGA3 gene encoding the alpha-subunit of the cone photoreceptor cGMP-gated channel cause autosomal recessive complete achromatopsia linked to chromosome 2q11...

  3. Does the Dirac cone of germanene exist on metal substrates? (United States)

    Wang, Yangyang; Li, Jingzhen; Xiong, Junhua; Pan, Yuanyuan; Ye, Meng; Guo, Ying; Zhang, Han; Quhe, Ruge; Lu, Jing


    Germanene, a germanium analogue of graphene and silicene, has been synthesized on metal substrates. It is predicted that the intrinsic germanene has a Dirac cone in its band structure, just like graphene and silicene. Using first-principles calculations, we investigate the geometrical structures and electronic properties of germanene on the Ag, Au, Cu, Al, Pt and Ir substrates. The Dirac cone of germanene is destroyed on the Al, Pt and Ir substrates but preserved on the Ag and Au substrates with a slight band hybridization. The upper part of the Dirac cone is destroyed for germanene on the Cu substrate while the lower part remains preserved. By contrast, the Dirac cone is always destroyed for silicene on these metal substrates because of a strong band hybridization. Our study suggests that it is possible to extract the intrinsic properties of germanene on the Ag and Au substrates although it appears impossible for silicene on these two substrates.

  4. Microhabitats within Venomous Cone Snails Contain Diverse Actinobacteria▿ † (United States)

    Peraud, Olivier; Biggs, Jason S.; Hughen, Ronald W.; Light, Alan R.; Concepcion, Gisela P.; Olivera, Baldomero M.; Schmidt, Eric W.


    Actinomycetes can be symbionts in diverse organisms, including both plants and animals. Some actinomycetes benefit their host by producing small molecule secondary metabolites; the resulting symbioses are often developmentally complex. Actinomycetes associated with three cone snails were studied. Cone snails are venomous tropical marine gastropods which have been extensively examined because of their production of peptide-based neurological toxins, but no microbiological studies have been reported on these organisms. A microhabitat approach was used in which dissected tissue from each snail was treated as an individual sample in order to explore bacteria in the tissues separately. Our results revealed a diverse, novel, and highly culturable cone snail-associated actinomycete community, with some isolates showing promising bioactivity in a neurological assay. This suggests that cone snails may represent an underexplored reservoir of novel actinomycetes of potential interest for drug discovery. PMID:19749071

  5. Determination of the Resistance of Cone-Shaped Solid Electrodes

    DEFF Research Database (Denmark)

    Frandsen, Henrik Lund; Hendriksen, Peter Vang; Koch, Søren


    during processing can be avoided. Newman's formula for current constriction in the electrolyte is then used to deduce the active contact area based on the ohmic resistance of the cell, and from this the surface specific electro-catalytic activity. However, for electrode materials with low electrical...... conductivity (like Ce1-xPrxO2-δ), the resistance of the cell is significantly influenced by the ohmic resistance of the cone electrode, wherefore it must be included. In this work the ohmic resistance of a cone is modelled analytically based on simplified geometries. The two analytical models only differ...... by a model specific pre-factor, which is consequently determined by a finite element model. The model was applied to measurements on cones of Ce1-xPrxO2-δ  characterized on an YSZ electrolyte. Conclusively, the finite element model was used to obtain a formula for the resistance for different cone angles...

  6. Fractional quantum Hall states of bosons on cones (United States)

    Wu, Ying-Hai; Tu, Hong-Hao; Sreejith, G. J.


    Motivated by a recent experiment, which synthesizes Landau levels for photons on cones [Schine et al., Nature (London) 534, 671 (2016), 10.1038/nature17943], and more generally the interest in understanding gravitational responses of quantum Hall states, we study fractional quantum Hall states of bosons on cones. A variety of trial wave functions for conical systems are constructed and compared with exact diagonalization results. The tip of a cone is a localized geometrical defect with singular curvature, which can modify the density profiles of quantum Hall states. The density profiles on cones can be used to extract some universal information about quantum Hall states. The values of certain quantities are computed numerically using the density profiles of some quantum Hall states and they agree with analytical predictions.

  7. Holographic entanglement entropy for hollow cones and banana shaped regions

    Energy Technology Data Exchange (ETDEWEB)

    Dorn, Harald [Institut für Physik und IRIS Adlershof, Humboldt-Universität zu Berlin,Zum Großen Windkanal 6, D-12489 Berlin (Germany)


    We consider banana shaped regions as examples of compact regions, whose boundary has two conical singularities. Their regularised holographic entropy is calculated with all divergent as well as finite terms. The coefficient of the squared logarithmic divergence, also in such a case with internally curved boundary, agrees with that calculated in the literature for infinite circular cones with their internally flat boundary. For the otherwise conformally invariant coefficient of the ordinary logarithmic divergence an anomaly under exceptional conformal transformations is observed. The construction of minimal submanifolds, needed for the entanglement entropy of cones, requires fine-tuning of Cauchy data. Perturbations of such fine-tuning leads to solutions relevant for hollow cones. The divergent parts for the entanglement entropy of hollow cones are calculated. Increasing the difference between the opening angles of their outer and inner boundary, one finds a transition between connected solutions for small differences to disconnected solutions for larger ones.

  8. Sustainability Evaluation. (United States)

    Stichnothe, Heinz


    The long-term substitution of fossil resources can only be achieved through a bio-based economy, with biorefineries and bio-based products playing a major role. However, it is important to assess the implications of the transition to a bio-based economy. Life cycle-based sustainability assessment is probably the most suitable approach to quantify impacts and to identify trade-offs at multiple levels. The extended utilisation of biomass can cause land use change and affect food security of the most vulnerable people throughout the world. Although this is mainly a political issue and governments should be responsible, the responsibility is shifted to companies producing biofuels and other bio-based products. Organic wastes and lignocellulosic biomass are considered to be the preferred feedstock for the production of bio-based products. However, it is unlikely that a bio-based economy can rely only on organic wastes and lignocellulosic biomass.It is crucial to identify potential problems related to socio-economic and environmental issues. Currently there are many approaches to the sustainability of bio-based products, both quantitative and qualitative. However, results of different calculation methods are not necessarily comparable and can cause confusion among decision-makers, stakeholders and the public.Hence, a harmonised, globally agreed approach would be the best solution to secure sustainable biomass/biofuels/bio-based chemicals production and trade, and to avoid indirect effects (e.g. indirect land use change). However, there is still a long way to go.Generally, the selection of suitable indicators that serve the purpose of sustainability assessment is very context-specific. Therefore, it is recommended to use a flexible and modular approach that can be adapted to various purposes. A conceptual model for the selection of sustainability indicators is provided that facilitates identifying suitable sustainability indicators based on relevance and significance in a

  9. Weather effects on the success of longleaf pine cone crops (United States)

    Daniel J. Leduc; Shi-Jean Susana Sung; Dale G. Brockway; Mary Anne Sword Sayer


    We used National Oceanic and Atmospheric Administration weather data and historical records of cone crops from across the South to relate weather conditions to the yield of cones in 10 longleaf pine (Pinus palustris Mill.) stands. Seed development in this species occurs over a three-year time period and weather conditions during any part of this...

  10. Scattering of wedges and cones with impedance boundary conditions

    CERN Document Server

    Lyalinov, Mikhail


    This book is a systematic and detailed exposition of different analytical techniques used in studying two of the canonical problems, the wave scattering by wedges or cones with impedance boundary conditions. It is the first reference on novel, highly efficient analytical-numerical approaches for wave diffraction by impedance wedges or cones. The applicability of the reported solution procedures and formulae to existing software packages designed for real-world high-frequency problems encountered in antenna, wave propagation, and radar cross section.

  11. Cinder cones of Mount Slamet, Central Java, Indonesia

    Directory of Open Access Journals (Sweden)

    Igan S. SutawIdjaja


    Full Text Available Mount Slamet volcanic field in Central Java, Indonesia, contains thirty five cinder cones within an area of 90 sq. km in the east flank of the volcano. The cinder cones occur singly or in small groups, with diameter of the base ranges from 130 - 750 m and the height is around 250 m. Within the volcanic field, the cinder cones are spread over the volcanic area at the distance of 4 to 14 km from the eruption center of the Slamet Volcano. They are concentrated within latitudes 7°11’00” - 7°16’00” S,, and longitudes 109°15’00” - 109°18’00” E. The density of the cinder cones is about 1.5 cones/km2. Most of the cinder cones lie on the Tertiary sedimentary rocks along the NW-trending fault system and on radial fractures. The structural pattern may be related to the radial faults in this region. The cone surfaces are commonly blanketed by Slamet air-falls and lava flows. The deposits consist of poorly bedded, very coarse-grained, occasionally overlain by oxidized scoria, and large-sized of ballistic bombs and blocks. There are various kind of volcanic bombs originating from scoriae ballistic rock fragments. The other kind of volcanic bombs are breadcrust bomb, almond seed or contorted shape. All of the cinder cones have undergone degradation, which can be observed from the characters of gully density and surface morphology. By using Porter parameters, Hco is equal to 0.25 Wco, whilst Wcr is equal to 0.40 Wco. The Hco/Wco ratio is higher than Hco = 0.2 Wco reference line. A radiometric dating using K-Ar method carried out on a scoria bomb yields the age of 0.042 + 0.020 Ma.  

  12. Efficacy of different concentrations of sodium hypochlorite and chlorhexidine in disinfection of contaminated Resilon cones


    Zand, Vahid; Salem Milani, Amin; Shahi, Shahriar; Akhi, Mohammad-Taghi; Vazifekhah, Siamak


    Objectives: The aim of this study was to evaluate the effectiveness of different concentrations of Chlorhexidine (CHX) and sodium hypochlorite (NaOCl) in disinfecting contaminated Resilon cones within one minute. Study design: Fifty Resilon cones were divided into seven experimental groups and three control groups of 5 cones each. The cones of experimental groups were contaminated with Entrococcus faecalis and subsequently disinfected with different concentrations of NaOCl or CHX. The cones w...

  13. Environmental law and sustainable development

    Directory of Open Access Journals (Sweden)

    María Oliva Sirgo Álvarez


    Full Text Available This article analyses the origin and birth of the human right to a safe and healthy environment in order to allow everyone to live a dignified and quality life. It also analyses the essential content of sustainable development, which must always guide the development of environmental law to ensure a healthy environment for human present and future generations, and a sustainable economic growth that contributes to the development of equal opportunities for all people.

  14. Meaning of visualizing retinal cone mosaic on adaptive optics images. (United States)

    Jacob, Julie; Paques, Michel; Krivosic, Valérie; Dupas, Bénédicte; Couturier, Aude; Kulcsar, Caroline; Tadayoni, Ramin; Massin, Pascale; Gaudric, Alain


    To explore the anatomic correlation of the retinal cone mosaic on adaptive optics images. Retrospective nonconsecutive observational case series. A retrospective review of the multimodal imaging charts of 6 patients with focal alteration of the cone mosaic on adaptive optics was performed. Retinal diseases included acute posterior multifocal placoid pigment epitheliopathy (n = 1), hydroxychloroquine retinopathy (n = 1), and macular telangiectasia type 2 (n = 4). High-resolution retinal images were obtained using a flood-illumination adaptive optics camera. Images were recorded using standard imaging modalities: color and red-free fundus camera photography; infrared reflectance scanning laser ophthalmoscopy, fluorescein angiography, indocyanine green angiography, and spectral-domain optical coherence tomography (OCT) images. On OCT, in the marginal zone of the lesions, a disappearance of the interdigitation zone was observed, while the ellipsoid zone was preserved. Image recording demonstrated that such attenuation of the interdigitation zone co-localized with the disappearance of the cone mosaic on adaptive optics images. In 1 case, the restoration of the interdigitation zone paralleled that of the cone mosaic after a 2-month follow-up. Our results suggest that the interdigitation zone could contribute substantially to the reflectance of the cone photoreceptor mosaic. The absence of cones on adaptive optics images does not necessarily mean photoreceptor cell death. Copyright © 2015 Elsevier Inc. All rights reserved.


    Directory of Open Access Journals (Sweden)

    Vladimir R. Alekseyev


    Full Text Available In the Earth’s regions with cold climate, cryovolcanism is widespread. This phenomena is manifested as eruptions of material due to freezing of closed-type or open-type water-bearing systems which is accompanied by generation of effusive topographic forms, such as «pingo». The Patom cone is a typical structure created by cryovolcanism in fractured bedrocksof the Proterozoic age. The cone was shaped a result of the long-term, possibly multistage freezing of the hydrogeological structure during continuous and complicated phase of cryo- and speleo-genesis. The ice-saturated breccia containing limestone, sandstone and shale, which composed the cone, was subject to slow spreading due to its plastic properties; the top of the mound developed into a subsidence cone bordered by ring-shaped ramparts and a knoll in the middle, while thelongitudinal profile took on an asymmetric form. The absence of soil and vegetation cover on the surface of the cone, and a relatively weak degree of weathering of the rudaceous deposits bear no evidence that the geological object is young. The question as to the age of the cone is still open.

  16. Heavy-to-light correlators beyond the light cone

    Energy Technology Data Exchange (ETDEWEB)

    Lucha, W.; Melikhov, D. I. [Austrian Academy of Sciences, Institute for High Energy Physics (Austria); Simula, S. [Sezione di Roma III, INFN (Italy)


    We present the first systematic analysis of the off-light-cone effects in correlators relevant for the extraction of the heavy-to-light form factors within the method of light-cone sum rules. In a model with scalar constituents, the correlator is calculated in two different ways: (i) by performing the expansion of the Bethe-Salpeter amplitude of the light meson near the light cone x{sup 2} = 0 and (ii) by adopting the known solution for the Bethe-Salpeter amplitude which allows one to calculate the correlator without invoking any expansion. We demonstrate that the contributions to the correlator from the off-light-cone terms x{sup 2} {ne} 0 are not suppressed by any large parameter compared to the contribution of the light-cone term x{sup 2} = 0. For decays of heavy particles of mass in the range 1.5-5 GeV, the light-cone correlator is shown to systematically overestimate the full correlator, numerically the difference being 10-20%.

  17. ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway. (United States)

    Ho, Lena; Tan, Shawn Y X; Wee, Sheena; Wu, Yixuan; Tan, Sam J C; Ramakrishna, Navin B; Chng, Serene C; Nama, Srikanth; Szczerbinska, Iwona; Sczerbinska, Iwona; Chan, Yun-Shen; Avery, Stuart; Tsuneyoshi, Norihiro; Ng, Huck Hui; Gunaratne, Jayantha; Dunn, N Ray; Reversade, Bruno


    ELABELA (ELA) is a peptide hormone required for heart development that signals via the Apelin Receptor (APLNR, APJ). ELA is also abundantly secreted by human embryonic stem cells (hESCs), which do not express APLNR. Here we show that ELA signals in a paracrine fashion in hESCs to maintain self-renewal. ELA inhibition by CRISPR/Cas9-mediated deletion, shRNA, or neutralizing antibodies causes reduced hESC growth, cell death, and loss of pluripotency. Global phosphoproteomic and transcriptomic analyses of ELA-pulsed hESCs show that it activates PI3K/AKT/mTORC1 signaling required for cell survival. ELA promotes hESC cell-cycle progression and protein translation and blocks stress-induced apoptosis. INSULIN and ELA have partially overlapping functions in hESC medium, but only ELA can potentiate the TGFβ pathway to prime hESCs toward the endoderm lineage. We propose that ELA, acting through an alternate cell-surface receptor, is an endogenous secreted growth factor in human embryos and hESCs that promotes growth and pluripotency. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Cone beam computed tomography in veterinary dentistry. (United States)

    Van Thielen, Bert; Siguenza, Francis; Hassan, Bassam


    The purpose of this study was to assess the feasibility of cone beam computed tomography (CBCT) in imaging dogs and cats for diagnostic dental veterinary applications. CBCT scans of heads of six dogs and two cats were made. Dental panoramic and multi-planar reformatted (MPR) para-sagittal reconstructions were created using specialized software. Image quality and visibility of anatomical landmarks were subjectively assessed by two observers. Good image quality was obtained for the MPR para-sagittal reconstructions through multiple teeth. The image quality of the panoramic reconstructions of dogs was moderate while the panoramic reconstructions of cats were poor since the images were associated with an increased noise level. Segmental panoramic reconstructions of the mouth seem to be useful for studying the dental anatomy especially in dogs. The results of this study using human dental CBCT technology demonstrate the potential of this scanning technology in veterinary medicine. Unfortunately, the moderate image quality obtained with the CBCT technique reported here seems to be inferior to the diagnostic image quality obtained from 2-dimensional dental radiographs. Further research is required to optimize scanning and reconstruction protocols for veterinary applications.

  19. Manipulation of Dirac Cones in Mechanical Graphene (United States)

    Kariyado, Toshikaze; Hatsugai, Yasuhiro


    Recently, quantum Hall state analogs in classical mechanics attract much attention from topological points of view. Topology is not only for mathematicians but also quite useful in a quantum world. Further it even governs the Newton’s law of motion. One of the advantages of classical systems over solid state materials is its clear controllability. Here we investigate mechanical graphene, which is a spring-mass model with the honeycomb structure as a typical mechanical model with nontrivial topological phenomena. The vibration spectrum of mechanical graphene is characterized by Dirac cones serving as sources of topological nontriviality. We find that the spectrum has dramatic dependence on the spring tension at equilibrium as a natural control parameter, i.e., creation and annihilation of the Dirac particles are realized as the tension increases. Just by rotating the system, the manipulated Dirac particles lead to topological transition, i.e., a jump of the “Chern number” occurs associated with flipping of propagating direction of chiral edge modes. This is a bulk-edge correspondence governed by the Newton’s law. A simple observation that in-gap edge modes exist only at the fixed boundary, but not at the free one, is attributed to the symmetry protection of topological phases.

  20. Manipulation of Dirac Cones in Mechanical Graphene (United States)

    Kariyado, Toshikaze; Hatsugai, Yasuhiro


    Recently, quantum Hall state analogs in classical mechanics attract much attention from topological points of view. Topology is not only for mathematicians but also quite useful in a quantum world. Further it even governs the Newton’s law of motion. One of the advantages of classical systems over solid state materials is its clear controllability. Here we investigate mechanical graphene, which is a spring-mass model with the honeycomb structure as a typical mechanical model with nontrivial topological phenomena. The vibration spectrum of mechanical graphene is characterized by Dirac cones serving as sources of topological nontriviality. We find that the spectrum has dramatic dependence on the spring tension at equilibrium as a natural control parameter, i.e., creation and annihilation of the Dirac particles are realized as the tension increases. Just by rotating the system, the manipulated Dirac particles lead to topological transition, i.e., a jump of the “Chern number” occurs associated with flipping of propagating direction of chiral edge modes. This is a bulk-edge correspondence governed by the Newton’s law. A simple observation that in-gap edge modes exist only at the fixed boundary, but not at the free one, is attributed to the symmetry protection of topological phases. PMID:26667580

  1. Cone Beam Computed Tomographic imaging in orthodontics. (United States)

    Scarfe, W C; Azevedo, B; Toghyani, S; Farman, A G


    Over the last 15 years, cone beam computed tomographic (CBCT) imaging has emerged as an important supplemental radiographic technique for orthodontic diagnosis and treatment planning, especially in situations which require an understanding of the complex anatomic relationships and surrounding structures of the maxillofacial skeleton. CBCT imaging provides unique features and advantages to enhance orthodontic practice over conventional extraoral radiographic imaging. While it is the responsibility of each practitioner to make a decision, in tandem with the patient/family, consensus-derived, evidence-based clinical guidelines are available to assist the clinician in the decision-making process. Specific recommendations provide selection guidance based on variables such as phase of treatment, clinically-assessed treatment difficulty, the presence of dental and/or skeletal modifying conditions, and pathology. CBCT imaging in orthodontics should always be considered wisely as children have conservatively, on average, a three to five times greater radiation risk compared with adults for the same exposure. The purpose of this paper is to provide an understanding of the operation of CBCT equipment as it relates to image quality and dose, highlight the benefits of the technique in orthodontic practice, and provide guidance on appropriate clinical use with respect to radiation dose and relative risk, particularly for the paediatric patient. © 2017 Australian Dental Association.

  2. Current emitted by highly conducting Taylor cones (United States)

    Delamora, J. Fernandez; Loscertales, I. G.


    When a liquid meniscus held at the exit of a metallic capillary tube is charged to a high voltage V, the free surface often takes the form of a cone whose apex emits a steady microjet, and thus injects a certain charge I and liquid volume Q per unit time into the surrounding gas. This work deals with liquids with relatively large conductivities K, for which the jet diameter d(j) is much smaller than the diameter d(n) of the capillary tube. In the limit d(j)/d(n) to O, the structure of the jet (d(j) and I, in particular) becomes independent of electrostatic parameters such as V or the electrode configuration, being governed mostly by the liquid properties and flow rate Q. Furthermore, the measured current is given approximately by I = f(epsilon)(gamma QK/epsilon)(exp 1/2) for a wide variety of liquids and conditions (epsilon, and gamma are, respectively, the dielectric constant of the liquid and the coefficient of interfacial tension, f(epsilon) is shown). A proposed explanation for this behavior is presented.

  3. The Light-Cone Gauge without Prescriptions (United States)

    Suzuki, A. T.; Schmidt, A. G. M.


    Feynman integrals in the physical light-cone gauge are more difficult to solve than their covariant counterparts. The difficulty is associated with the presence of unphysical singularities due to the inherent residual gauge freedom in the intermediate boson propagators constrained within this gauge choice. In order to circumvent these non-physical singularities, the headlong approach has always been to call for mathematical devices --- prescriptions --- some successful and others not. A more elegant approach is to consider the propagator from its physical point of view, that is, an object obeying basic principles such as causality. Once this fact is realized and carefully taken into account, the crutch of prescriptions can be avoided altogether. An alternative, third approach, which for practical computations could dispense with prescriptions as well as avoiding the necessity of careful stepwise consideration of causality, would be of great advantage. And this third option is realizable within the context of negative dimensions, or as it has been coined, the negative dimensional integration method (NDIM).

  4. Roles of ON Cone Bipolar Cell Subtypes in Temporal Coding in the Mouse Retina (United States)

    Fyk-Kolodziej, Bozena; Cohn, Jesse


    In the visual system, diverse image processing starts with bipolar cells, which are the second-order neurons of the retina. Thirteen subtypes of bipolar cells have been identified, which are thought to encode different features of image signaling and to initiate distinct signal-processing streams. Although morphologically identified, the functional roles of each bipolar cell subtype in visual signal encoding are not fully understood. Here, we investigated how ON cone bipolar cells of the mouse retina encode diverse temporal image signaling. We recorded bipolar cell voltage changes in response to two different input functions: sinusoidal light and step light stimuli. Temporal tuning in ON cone bipolar cells was diverse and occurred in a subtype-dependent manner. Subtypes 5s and 8 exhibited low-pass filtering property in response to a sinusoidal light stimulus, and responded with sustained fashion to step-light stimulation. Conversely, subtypes 5f, 6, 7, and XBC exhibited bandpass filtering property in response to sinusoidal light stimuli, and responded transiently to step-light stimuli. In particular, subtypes 7 and XBC were high-temporal tuning cells. We recorded responses in different ways to further examine the underlying mechanisms of temporal tuning. Current injection evoked low-pass filtering, whereas light responses in voltage-clamp mode produced bandpass filtering in all ON bipolar cells. These findings suggest that cone photoreceptor inputs shape bandpass filtering in bipolar cells, whereas intrinsic properties of bipolar cells shape low-pass filtering. Together, our results demonstrate that ON bipolar cells encode diverse temporal image signaling in a subtype-dependent manner to initiate temporal visual information-processing pathways. PMID:24966376

  5. Singularities of plane complex curves and limits of Kähler metrics with cone singularities. I: Tangent Cones

    Directory of Open Access Journals (Sweden)

    Borbon Martin de


    Full Text Available The goal of this article is to provide a construction and classification, in the case of two complex dimensions, of the possible tangent cones at points of limit spaces of non-collapsed sequences of Kähler-Einstein metrics with cone singularities. The proofs and constructions are completely elementary, nevertheless they have an intrinsic beauty. In a few words; tangent cones correspond to spherical metrics with cone singularities in the projective line by means of the Kähler quotient construction with respect to the S1-action generated by the Reeb vector field, except in the irregular case ℂβ₁×ℂβ₂ with β₂/ β₁ ∉ Q.

  6. Towards sustainable development (United States)

    Munn, R. E.

    Sustainable development is a difficult phrase to define, particularly in the context of human ecosystems. Questions have to be asked, such as "Sustainable for whom?" "Sustainable for what purposes?" "Sustainable at the subsistence or at the luxury level?" and "Sustainable under what conditions?" In this paper, development is taken to mean improving the quality of life. (If development were to mean growth, then it could not be sustained over the long term.) Studies of development must, of course, consider economic factors, particularly in the case of societies who suffer from the pollution of poverty. However, cultural and environmental factors are equally important. In fact, development is not sustainable over the long term if it is not ecologically sustainable. The terms maximum sustainable yield of a renewable resource, carrying capacity of a region and assimilative capacity of a watershed or airshed are discussed. Approaches using these resource management tools are recommended when external conditions are not changing very much. The problem today is that unprecedented rates of change are expected in the next century, not only of environmental conditions such as climate but also of socioeconomic conditions such as renewable resource consumption and populations (of both people and of automobiles)! In rapidly changing situations, policies must be adopted that strengthen resilence and ecosystem integrity; that is, society must increase its ability to adapt. Maintaining the status quo is a long-term prescription for disaster. The problem is of course that little is known about how to design strategies that will increase resilience and ecosystem integrity, and this area of research needs to be strengthened. Some suggestions on appropriate indicators of ecosystem integrity are given in the paper but these need considerable refinement. One of the main problems with long-term environmental policy formulation is the uncertainty to be expected, including the possibility

  7. Sustainable Soesterkwartier

    NARCIS (Netherlands)

    Abrahams, H.; Goosen, H.; Jong, de F.; Sickmann, J.; Prins, D.


    The municipality of Amersfoort wants to construct an endurable and sustainable eco-town in the Soesterkwartier neighbourhood, by taking future climate change into account. The impact of climate change at the location of the proposed eco-town was studied by a literature review.

  8. Sustainable agriculture

    International Development Research Centre (IDRC) Digital Library (Canada)

    New farming techniques, better food security. Since 1970, IDRC-supported research has introduced sustainable agricultural practices to farmers and communities across the devel- oping world. The result: higher productivity, less poverty, greater food security, and a healthier environment. Opportunities grow on trees in ...

  9. Sustainable Development

    African Journals Online (AJOL)

    Tsegai Berhane Ghebretekle

    Abstract. This article examines the concept of sustainable development after the Post-. 2015 Paris Climate Change Agreement with particular emphasis on Ethiopia. Various African countries are vulnerable to climate change, as is evidenced by recent droughts. Ethiopia is selected as a case study in light of its pace in.

  10. Sustainable machining

    CERN Document Server


    This book provides an overview on current sustainable machining. Its chapters cover the concept in economic, social and environmental dimensions. It provides the reader with proper ways to handle several pollutants produced during the machining process. The book is useful on both undergraduate and postgraduate levels and it is of interest to all those working with manufacturing and machining technology.

  11. Architecture Sustainability

    NARCIS (Netherlands)

    Avgeriou, Paris; Stal, Michael; Hilliard, Rich


    Software architecture is the foundation of software system development, encompassing a system's architects' and stakeholders' strategic decisions. A special issue of IEEE Software is intended to raise awareness of architecture sustainability issues and increase interest and work in the area. The

  12. Sustainability reporting

    NARCIS (Netherlands)

    Kolk, A.


    This article gives an overview of developments in sustainability (also sometimes labelled corporate social responsibility) reporting. It The article will first briefly indicate how accountability on social and environmental issues started, already in the 1970s when social reports were published.

  13. Exergy sustainability.

    Energy Technology Data Exchange (ETDEWEB)

    Robinett, Rush D. III (.; ); Wilson, David Gerald; Reed, Alfred W.


    Exergy is the elixir of life. Exergy is that portion of energy available to do work. Elixir is defined as a substance held capable of prolonging life indefinitely, which implies sustainability of life. In terms of mathematics and engineering, exergy sustainability is defined as the continuous compensation of irreversible entropy production in an open system with an impedance and capacity-matched persistent exergy source. Irreversible and nonequilibrium thermodynamic concepts are combined with self-organizing systems theories as well as nonlinear control and stability analyses to explain this definition. In particular, this paper provides a missing link in the analysis of self-organizing systems: a tie between irreversible thermodynamics and Hamiltonian systems. As a result of this work, the concept of ''on the edge of chaos'' is formulated as a set of necessary and sufficient conditions for stability and performance of sustainable systems. This interplay between exergy rate and irreversible entropy production rate can be described as Yin and Yang control: the dialectic synthesis of opposing power flows. In addition, exergy is shown to be a fundamental driver and necessary input for sustainable systems, since exergy input in the form of power is a single point of failure for self-organizing, adaptable systems.

  14. Sustainable processing

    DEFF Research Database (Denmark)

    Kristensen, Niels Heine


    Kristensen_NH and_Beck A: Sustainable processing. In Otto Schmid, Alexander Beck and Ursula Kretzschmar (Editors) (2004): Underlying Principles in Organic and "Low-Input Food" Processing - Literature Survey. Research Institute of Organic Agriculture FiBL, CH-5070 Frick, Switzerland. ISBN 3-906081-58-3...

  15. Sustainable finance

    NARCIS (Netherlands)

    dr. Margreet F. Boersma-de Jong


    Presentation for Springschool of Strategy, University of Groningen, 10 October 2012. The role of CSR is to stimulate ethical behaviour, and as a result, mutual trust in society. Advantage of CSR for the company and the evolution of CSR. From CSR to Sustainable Finance: how does CSR influence

  16. Comparative analysis between mandibular positions in centric relation and maximum intercuspation by cone beam computed tomography (CONE-BEAM)


    FERREIRA, Amanda de Freitas; Henriques,João César Guimarães; Almeida,Guilherme Araújo; Machado, Asbel Rodrigues; Machado, Naila Aparecida de Godoi; Fernandes Neto,Alfredo Júlio


    This research consisted of a quantitative assessment, and aimed to measure the possible discrepancies between the maxillomandibular positions for centric relation (CR) and maximum intercuspation (MI), using computed tomography volumetric cone beam (cone beam method). The sample of the study consisted of 10 asymptomatic young adult patients divided into two types of standard occlusion: normal occlusion and Angle Class I occlusion. In order to obtain the centric relation, a JIG device and mandi...

  17. Comparative analysis between mandibular positions in centric relation and maximum intercuspation by cone beam computed tomography (CONE-BEAM)


    FERREIRA, Amanda de Freitas; HENRIQUES, Jo?o C?sar Guimar?es; Almeida, Guilherme de Ara?jo; Machado, Asbel Rodrigues; Machado, Naila Aparecida de Godoi; Fernandes, Alfredo J?lio


    ABSTRACT This research consisted of a quantitative assessment, and aimed to measure the possible discrepancies between the maxillomandibular positions for centric relation (CR) and maximum intercuspation (MI), using computed tomography volumetric cone beam (cone beam method). The sample of the study consisted of 10 asymptomatic young adult patients divided into two types of standard occlusion: normal occlusion and Angle Class I occlusion. In order to obtain the centric relation, a JIG device ...

  18. The early effects of sustained platelet-derived growth factor administration on the functional and structural properties of repaired intrasynovial flexor tendons: an in vivo biomechanic study at 3 weeks in canines. (United States)

    Gelberman, Richard H; Thomopoulos, Stavros; Sakiyama-Elbert, Shelly E; Das, Rosalina; Silva, Matthew J


    A bioactive fibrin-based delivery system was used to provide sustained administration of platelet-derived growth factor (PDGF-BB) in a clinically relevant model of intrasynovial flexor tendon repair. We hypothesized that PDGF-BB administered in this manner would improve the sutured tendon's functional and structural properties 3 weeks after repair. A delivery system consisting of 30 microL of fibrin matrix, peptide, heparin, and 100 ng of PDGF-BB was incorporated into the repair sites of randomly selected medial or lateral forepaw flexor digitorum profundus tendons of 8 adult mongrel dogs. The remaining forepaw flexor digitorum profundus tendons were repaired without the growth-factor and fibrin-based delivery system and served as controls. The surgically treated forelimbs were treated with controlled passive motion rehabilitation. The animals were killed at 3 weeks, at which time the tendons were tested for range of motion with a motion analysis system and for tensile properties with a materials testing machine. Proximal interphalangeal joint and distal interphalangeal joint rotation values were significantly higher for the PDGF-BB-treated tendons compared with the repair-alone tendons. Excursion values were also significantly higher in the PDGF-BB-treated tendons. There were no significant differences in tensile properties when comparing PDGF-BB-treated with repair-alone tendons. The functional properties of repaired intrasynovial flexor tendons were significantly improved with the sustained administration of PDGF-BB. The failure to achieve improvements in ultimate load, stiffness, and strain in the experimental group may have been due to suboptimal PDGF-BB dosage or suboptimal release kinetics.

  19. Sustaining protein synthesis in the absence of rapid cell division: an investigation of plasmid-encoded protein expression in Escherichia coli during very slow growth. (United States)

    Flickinger, M C; Rouse, M P


    The minimum growth rate capable of supporting plasmid-encoded gene expression is determined using continuous cultures of Escherichia coli MZ9387 at dilution rates (D) as low as 5% of the maximum specific growth rate. Expression from a low copy number plasmid, pMPR166, encoding cyanase under the control of P(lac) is investigated in order to study plasmid-encoded gene expression under conditions approaching starvation. Plasmid copy number was stabilized by selection in the presence of 500 micrograms/mL chloramphenicol by constitutive expression of chloramphenicol acetyl transferase (CAT). Plasmid retention was determined by dot-blot hybridization and chloramphenicol resistance. The contribution of plasmid maintenance and cyanase expression to the maximum cell yield (Y'x/s) and the maintenance coefficient (ms) was determined for MZ9387 and MZ9387:pMPR166 under uninduced and IPTG-induced conditions. The values of Y'x/s and ms for non-plasmid-bearing cultures were 0.56 g of cell dry mass (DCM)/g of glucose and 0.26 g of glucose/g of DCM.h, respectively. The cell yield for plasmid-bearing cultures under uninduced conditions (Y 0'x/s) was 0.28 g of DCM/g of glucose, with m0s = 0.08 g of glucose/g of DCM.h. These values decreased following induction of cyanase expression. Glucose consumption in the presence of IPTG was linearly related to the growth rate at D cyanase expression alters metabolism and glucose consumption. The fraction of plasmid-free cells decreased with decreasing Damköhler number (Da). These data confirm the usefulness of Da for predicting the relationship between plasmid-free and plasmid-bearing cells where plasmids are stabilized by concentrations of antibiotic greater than the minimum plasmid-free host cell growth inhibitory concentration. Specific cyanase expression increased as the dilution rate decreased to D = 0.15 h-1. Between D = 0.15 h-1 and D = 0.14 h-1, expression decreased 7-fold. At very low dilution rates (D < or = 0.06 h-1), nonseptated

  20. Innovative strategies for environmental sustainability

    Energy Technology Data Exchange (ETDEWEB)

    Rouhani, S. [Georgia Institute of Technology, Atlanta, GA (United States)]|[NewFields, Inc., Atlanta, GA (United States)


    Since the early 1980s our preception of sustainability has fundamentally changed. History sustainability was primarily concerned with the scarcity of natural resources in the face of a growing world population. Awareness of ecological and environmental degradations has come gradually. At first the solution to environmental problems such as global warming, ozone layer depletion, and hazardous waste appeared to require a halt in global economic growth. However creative solutions which address environmental issues and produce economic growth have come to the fore. This paper focuses this with respect to the clean-up of contaminated sites - remediation and case studies.

  1. 2016 RAD-AID Conference on International Radiology for Developing Countries: Gaps, Growth, and United Nations Sustainable Development Goals. (United States)

    Mollura, Daniel J; Soroosh, Garshasb; Culp, Melissa P


    The 2016 RAD-AID Conference analyzed the accelerated global activity in the radiology community that is transforming medical imaging into an effective spearhead of health care capacity building in low- and middle-income countries. Global health efforts historically emphasized disaster response, crisis zones, and infectious disease outbreaks. However, the projected doubling of cancer and cardiovascular deaths in developing countries in the next 15 years and the need for higher technology screening and diagnostic technologies in low-resource regions, as articulated by the United Nations' new Sustainable Development Goals of 2016, is heightening the role of radiology in global health. Academic US-based radiology programs with RAD-AID chapters achieved a threefold increase in global health project offerings for trainees in the past 5 years. RAD-AID's nonprofit radiology volunteer corps continue to grow by more than 40% yearly, with a volunteer base of 5,750 radiology professionals, serving in 23 countries, donating close to 20,000 pro bono hours globally in 2016. As a high-technology specialty interfacing with nearly all medical and surgical disciplines, radiology underpins vital health technology infrastructure, such as digital imaging archives, electronic medical records, and advanced diagnosis and treatment, essential for long-term future health care capacity in underserved areas of the world. Published by Elsevier Inc.

  2. The macroecology of sustainability.

    Directory of Open Access Journals (Sweden)

    Joseph R Burger

    Full Text Available The discipline of sustainability science has emerged in response to concerns of natural and social scientists, policymakers, and lay people about whether the Earth can continue to support human population growth and economic prosperity. Yet, sustainability science has developed largely independently from and with little reference to key ecological principles that govern life on Earth. A macroecological perspective highlights three principles that should be integral to sustainability science: 1 physical conservation laws govern the flows of energy and materials between human systems and the environment, 2 smaller systems are connected by these flows to larger systems in which they are embedded, and 3 global constraints ultimately limit flows at smaller scales. Over the past few decades, decreasing per capita rates of consumption of petroleum, phosphate, agricultural land, fresh water, fish, and wood indicate that the growing human population has surpassed the capacity of the Earth to supply enough of these essential resources to sustain even the current population and level of socioeconomic development.

  3. Formulation of a protein-free medium based on IPL-41 for the sustained growth of Drosophila melanogaster S2 cells. (United States)

    Batista, Fabiana R X; Pereira, Carlos A; Mendonça, Ronaldo Z; Moraes, Angela M


    An animal protein-free medium was developed for Drosophila melanogaster S2 (S2AcGPV2) cells genetically modified to produce the rabies virus G glycoprotein (GPV). IPL-41, used as a basal medium, was supplemented with yeastolate, carbohydrates, amino acids and lipids aiming initially to reduce and further to eliminate the need of fetal bovine serum. The S2AcGPV2 cells were fully capable of growing in serum-free supplemented IPL-41 medium containing 6 g L(-1) yeastolate ultrafiltrate, 10 g L(-1) glucose, 3.5 g L(-1) glutamine, 0.5 g L(-1) fructose, 2 g L(-1) lactose, 0.6 g L(-1) tyrosine, 1.48 g L(-1) methionine and 1% (v/v) lipid emulsion, reaching 19 x 10(6) cells mL(-1). Maximum specific growth rate and cell productivity were 0.025 h(-1) and 0.57 x 10(5) cells mL(-1) h(-1), respectively. Glucose and lactose were consumed during cell culture, but not fructose. Lactate concentration generally decreased during cell culture, while ammonium concentration reached 167 mg L(-1), however, without noticeable deleterious effects on cell growth. GPV concentration values achieved were, however, modest in the proposed medium formulation.


    Directory of Open Access Journals (Sweden)



    Full Text Available In recent decades, the image of the international business environment has changed significantly. Studies conducted by UNCTAD shows that corporate phenomenon developments in the world economy is growing. Without claiming to present an exhaustive topic so vast we tried to capture some "facets" of sustainable development from the perspective of multinational corporations, given the expansion of these economic entities and strengthening their power in the global economy. We present more negative aspects of the actions of multinational corporations in terms of sustainable development, it is very important to know both sides of the coin, which will not only help transnational giants including release. Based on issues such as corporate social responsibility, environmental pollution and workers' rights, we sought to counter official statements. The conclusion is that these economic entities are real forces that can not be ignored in today's world and the obvious problem of sustainable development can not be addressed independently of the phenomenon, context we also identified some possible solutions to conflict of corporations and essence of the concept of sustainable development.

  5. Sustainable Consumption

    DEFF Research Database (Denmark)

    Røpke, Inge


    in wider social, economic and technological frameworks is emphasised. In particular, the chapter is inspired by practice theory and transition theory. First, various trends in consumption are outlined to highlight some of the challenges for sustainability transitions. Then, it is discussed how consumption...... patterns are shaped over time and what should be considered in sustainability strategies. While discussions on consumption often take their point of departure in the perspective of the individual and then zoom to the wider context, the present approach is the opposite. The outline starts with the basic...... biophysical, distributional and economic conditions for high consumption in rich countries and then zooms in on the coevolution of provision systems and consumption, and how consumption is shaped by practices and projects in everyday life. Furthermore, the paper discusses whether and how transition...

  6. Sustainable Buildings

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Elle, Morten

    The scientific community agrees that: all countries must drastically and rapidly reduce their CO2 emissions and that energy efficient houses play a decisive role in this. The general attitude at the workshop on Sustainable Buildings was that we face large and serious climate change problems that ...... that need urgent action. The built environment is an obvious area to put effort into because of the large and cost-effective energy saving potential and potential for Renewable Energy-based supply systems for buildings.......The scientific community agrees that: all countries must drastically and rapidly reduce their CO2 emissions and that energy efficient houses play a decisive role in this. The general attitude at the workshop on Sustainable Buildings was that we face large and serious climate change problems...

  7. An Analysis Model for Water Cone Subsidence in Bottom Water Drive Reservoirs (United States)

    Wang, Jianjun; Xu, Hui; Wu, Shucheng; Yang, Chao; Kong, lingxiao; Zeng, Baoquan; Xu, Haixia; Qu, Tailai


    Water coning in bottom water drive reservoirs, which will result in earlier water breakthrough, rapid increase in water cut and low recovery level, has drawn tremendous attention in petroleum engineering field. As one simple and effective method to inhibit bottom water coning, shut-in coning control is usually preferred in oilfield to control the water cone and furthermore to enhance economic performance. However, most of the water coning researchers just have been done on investigation of the coning behavior as it grows up, the reported studies for water cone subsidence are very scarce. The goal of this work is to present an analytical model for water cone subsidence to analyze the subsidence of water cone when the well shut in. Based on Dupuit critical oil production rate formula, an analytical model is developed to estimate the initial water cone shape at the point of critical drawdown. Then, with the initial water cone shape equation, we propose an analysis model for water cone subsidence in bottom water reservoir reservoirs. Model analysis and several sensitivity studies are conducted. This work presents accurate and fast analytical model to perform the water cone subsidence in bottom water drive reservoirs. To consider the recent interests in development of bottom drive reservoirs, our approach provides a promising technique for better understanding the subsidence of water cone.


    Directory of Open Access Journals (Sweden)

    Constantinescu Andreea


    Full Text Available Even if sustainable development is a concept that gained quite recently its scientific prestige, through contribution of researchers its content has upgraded to a high degree of conceptual luggage and, through contribution from governance representatives, has gained an impressive good-practice background. Allowing the use of different methodological premises and conceptual tools, sustainable development paradigm is equipped with all the elements that would allow the opening of new horizons of knowledge. Based on the facility which can operate the concept of sustainable development, the European Union aims to develop both a more competitive economy based on environmental protection as well as a new governance of economic policy. This on one hand demonstrates the sustainable development ability to irradiate creativity towards the establishment of interdisciplinary bridges and on the other hand explains the growing interest of researchers interested in the problem of analyzing in detail this fruitful concept. Launched first as a theoretical framework to serve justify actions responsible for weighting economic growth, the concept of Sustainable Development has quickly become a topic of ethical debate circumscribed to the area of perfectibility of human nature to the necessity registry. In this regard, the philosophical content of this paradigm could not remain outside researchers concerns, who want to provide both policy makers and the general public a wide range of evidence to demonstrate the viability of this paradigm. Academia waits until maximization of the contribution of governance to achieve sustainable economic development, which consists in conjunction of this upward path with the momentum given by public policy sync, perfectly adapted for globalization era and all crises to come. However, because this concept based its structure and composition on three pillars, equally important economy, society and environment any attempt to strengthen

  9. Grain Amaranths Are Defoliation Tolerant Crop Species Capable of Utilizing Stem and Root Carbohydrate Reserves to Sustain Vegetative and Reproductive Growth after Leaf Loss (United States)

    Vargas-Ortiz, Erandi; Espitia-Rangel, Eduardo; Tiessen, Axel; Délano-Frier, John Paul


    Tolerance to defoliation can be defined as the degree to which productivity is affected by photosynthetic area reduction. This trait was studied in grain amaranth (Amaranthus cruentus and A. hypochondriacus), which are considered to be a highly defoliation-tolerant species. The physiological and biochemical responses to increasing levels of mechanical leaf removal up to total defoliation were quantified. Tolerance appeared to be dependent on various factors: ( i) amount of lost tissue; (ii) mechanics of leaf tissue removal; (iii) environment, and (iv) species tested. Thus, grain amaranth was found to be a highly tolerant species under green-house conditions when leaf tissue loss was performed by gradual perforation. However, tolerance was compromised under similar conditions when defoliation was done by gradual cutting of the leaf. Also tolerance in completely defoliated plants tended to decrease under field conditions, where differences between A. cruentus and A. hypochondriacus were observed. All non-structural carbohydrate (NSC) levels were reduced in stems and roots of totally defoliated amaranths one day after treatment. Such depletion probably provided the carbon (C) resources needed to sustain the early recovery process in the absence of photosynthetic capacity. This was corroborated by shading of intact plants, which produced the same rapid and drastic reduction of NSC levels in these tissues. These results emphasize the role of stored NSCs, particularly starch, in buffering the impact of severe defoliation in amaranth. The fall in sucrose synthase and cell wall invertase activity observed in stems and roots soon after defoliation was consistent with their predicted shift from sink to source tissues. It is concluded that mobilization of C stores in stems and roots, is a physiologically important trait underlying tolerance to defoliation in grain amaranth. PMID:23861825

  10. Grain amaranths are defoliation tolerant crop species capable of utilizing stem and root carbohydrate reserves to sustain vegetative and reproductive growth after leaf loss.

    Directory of Open Access Journals (Sweden)

    Erandi Vargas-Ortiz

    Full Text Available Tolerance to defoliation can be defined as the degree to which productivity is affected by photosynthetic area reduction. This trait was studied in grain amaranth (Amaranthus cruentus and A. hypochondriacus, which are considered to be a highly defoliation-tolerant species. The physiological and biochemical responses to increasing levels of mechanical leaf removal up to total defoliation were quantified. Tolerance appeared to be dependent on various factors: ( i amount of lost tissue; (ii mechanics of leaf tissue removal; (iii environment, and (iv species tested. Thus, grain amaranth was found to be a highly tolerant species under green-house conditions when leaf tissue loss was performed by gradual perforation. However, tolerance was compromised under similar conditions when defoliation was done by gradual cutting of the leaf. Also tolerance in completely defoliated plants tended to decrease under field conditions, where differences between A. cruentus and A. hypochondriacus were observed. All non-structural carbohydrate (NSC levels were reduced in stems and roots of totally defoliated amaranths one day after treatment. Such depletion probably provided the carbon (C resources needed to sustain the early recovery process in the absence of photosynthetic capacity. This was corroborated by shading of intact plants, which produced the same rapid and drastic reduction of NSC levels in these tissues. These results emphasize the role of stored NSCs, particularly starch, in buffering the impact of severe defoliation in amaranth. The fall in sucrose synthase and cell wall invertase activity observed in stems and roots soon after defoliation was consistent with their predicted shift from sink to source tissues. It is concluded that mobilization of C stores in stems and roots, is a physiologically important trait underlying tolerance to defoliation in grain amaranth.

  11. Sustained low-dose growth hormone therapy optimizes bioactive insulin-like growth factor-I level and may enhance CD4 T-cell number in HIV infection

    DEFF Research Database (Denmark)

    Andersen, Ove; Hansen, Birgitte Rønde; Troensegaard, William


    High-dose recombinant human growth hormone (rhGH) (2-6 mg/day) regimes may facilitate T-cell restoration in patients infected with human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART). However, high-dose rhGH regimens increase insulin-like growth factor-I (IGF......-I) to supra-physiological levels associated with severe side effects. The present study investigated whether lower doses of rhGH may improve T-cell restoration in patients infected with HIV following an expedient response of total and bioactive (i.e., free) IGF-I. A previous 16-week pilot-study included six...... levels. These data support the notion that low-dose rhGH regimens may increase expediently total and bioactive IGF-I and improve T-cell restoration in patients infected with HIV on HAART....

  12. Méthode analytique généralisée pour le calcul du coning. Nouvelle solution pour calculer le coning de gaz, d'eau et double coning dans les puits verticaux et horizontaux Generalized Analytical Method for Coning Calculation. New Solution to Calculation Both the Gas Coning, Water Coning and Dual Coning for Vertical and Horizontal Wells

    Directory of Open Access Journals (Sweden)

    Pietraru V.


    Full Text Available Une nouvelle méthode analytique d'évaluation du coning d'eau par bottom water drive et/ou de gaz par gas-cap drive dans les puits horizontaux et verticaux a été développée pour les réservoirs infinis [1]. Dans cet article, une généralisation de cette méthode est présentée pour les réservoirs confinés d'extension limitée dont le toit est horizontal. La généralisation proposée est basée sur la résolution des équations différentielles de la diffusivité avec prise en compte des effets de drainage par gravité et des conditions aux limites pour un réservoir confiné. La méthode est applicable aux réservoirs isotropes ou anisotropes. L'hypothèse de pression constante à la limite de l'aire de drainage dans l'eau et/ou dans le gaz a été adoptée. Les pertes de charge dans l'aquifère et dans le gas-cap sont donc négligées. Les principales contributions de cet article sont : - L'introduction de la notion de rayon de cône, différent du rayon de puits. La hauteur du cône et le débit critique dépendent du rayon de cône alors qu'ils sont indépendants du rayon du puits. - Une nouvelle corrélation pour le calcul du débit critique sous forme adimensionnelle en fonction de trois paramètres : le temps, la longueur du drain horizontal (nulle pour un puits vertical et le rayon de drainage. - Des corrélations pour le calcul du rapport des débits gaz/huile (GOR ou de la fraction en eau (fw, pendant les périodes critique et postcritique, qui tiennent compte de la pression capillaire et des perméabilités relatives. - Des corrélations pour le calcul des rapports de débits gaz/huile et eau/huile pendant les périodes pré, post et supercritique en double coning. - Des critères pour le calcul du temps de percée au puits en simple coning de gaz ou d'eau, ou en double coning de gaz et d'eau. A new analytical method for assessing water and/or gas coning in horizontal and vertical wells has been developed for infinite

  13. The application of appropriate technologies and systems for sustainable sanitation

    CSIR Research Space (South Africa)

    Duncker, Louiza C


    Full Text Available Sustainable development, which encompasses sustainable sanitation, is defined as development that is appropriate, has the specific objectives of accelerated growth, targeted interventions and community mobilisation to eradicate poverty and focuses...

  14. Port Stakeholder Summit: Advancing More Sustainable Ports (April 2014) (United States)

    EPA's National Port Stakeholders Summit, Advancing More Sustainable Ports, focused on actions to protect air quality while reducing climate risk and supporting economic growth, making ports more environmentally sustainable.

  15. Spray cone angle and air core diameter of hollow cone swirl rocket injector

    Directory of Open Access Journals (Sweden)

    Ahmad Hussein Abdul Hamid


    Full Text Available ABSTRACT : Fuel injector for liquid rocket is a very critical component since that small difference in its design can dramatically affect the combustion efficiency. The primary function of the injector is to break the fuel up into very small droplets. The smaller droplets are necessary for fast quiet ignition and to establish a flame front close to the injector head, thus shorter combustion chamber is possible to be utilized. This paper presents an experimetal investigation of a mono-propellant hollow cone swirl injector. Several injectors with different configuration were investigated under cold flow test, where water is used as simulation fluid. This investigation reveals that higher injection pressure leads to higher spray cone angle. The effect of injection pressure on spray cone angle is more prominent for injector with least number of tangential ports. Furthermore, it was found that injector with the most number of tangential ports and with the smallest tangential port diameter produces the widest resulting spray. Experimental data also tells that the diameter of an air core that forms inside the swirl chamber is largest for the injector with smallest tangential port diameter and least number of tangential ports.ABSTRAK : Injektor bahan api bagi roket cecair merupakan satu komponen yang amat kritikal memandangkan perbezaan kecil dalam reka bentuknya akan secara langsung mempengaruhi kecekapan pembakaran. Fungsi utama injektor adalah untuk memecahkan bahan api kepada titisan yang amat kecil. Titisan kecil penting untuk pembakaran pantas secara senyap dan untuk mewujudkan satu nyalaan di hadapan, berhampiran dengan kepala injektor, maka kebuk pembakaran yang lebih pendek berkemungkinan dapat digunakan. Kertas kerja ini mebentangkan satu penyelidikan eksperimental sebuah injektor ekabahan dorong geronggang kon pusar. Beberapa injektor dengan konfigurasi berbeza telah dikaji di bawah ujian aliran sejuk, di mana air digunakan sebagai bendalir

  16. Design of a cone target for fast ignition

    Directory of Open Access Journals (Sweden)

    Sunahara Atsushi


    Full Text Available We propose a new type of target for the fast ignition of inertial confinement fusion. Pre-formed plasma inside a cone target can significantly reduce the energy coupling efficiency from the ultra-high intense short-pulse laser to the imploded core plasma. Also, in order to protect the tip of the cone and reduce generation of pre-formed plasma, we propose pointed shaped cone target. In our estimation, the shock traveling time can be delayed 20–30 ps by lower-Z material with larger areal density compared to the conventional gold flat tip. Also, the jet flow can sweep the blow-off plasma from the tip of the cone, and the implosion performance is not drastically affected by the existence of pointed tip. In addition, the self-generated magnetic field is generated along the boundary of cone tip and surrounding CD or DT plasma. This magnetic field can confine fast electrons and focus to the implosion core plasma. Resultant heating efficiency is improved by 30% compared to that with conventional gold flat tip.

  17. The photocurrent response of human cones is fast and monophasic

    Directory of Open Access Journals (Sweden)

    Lamb TD


    Full Text Available Abstract Background The precise form of the light response of human cone photoreceptors in vivo has not been established with certainty. To investigate the response shape we compare the predictions of a recent model of transduction in primate cone photoreceptors with measurements extracted from human cones using the paired-flash electroretinogram method. As a check, we also compare the predictions with previous single-cell measurements of ground squirrel cone responses. Results The predictions of the model provide a good description of the measurements, using values of parameters within the range previously determined for primate retina. The dim-flash response peaks in about 20 ms, and flash responses at all intensities are essentially monophasic. Three time constants in the model are extremely short: the two time constants for inactivation (of visual pigment and of transducin/phosphodiesterase are around 3 and 10 ms, and the time constant for calcium equilibration lies in the same range. Conclusion The close correspondence between experiment and theory, using parameters previously derived for recordings from macaque retina, supports the notion that the electroretinogram approach and the modelling approach both provide an accurate estimate of the cone photoresponse in the living human eye. For reasons that remain unclear, the responses of isolated photoreceptors from the macaque retina, recorded previously using the suction pipette method, are considerably slower than found here, and display biphasic kinetics.

  18. Generalized Fourier slice theorem for cone-beam image reconstruction. (United States)

    Zhao, Shuang-Ren; Jiang, Dazong; Yang, Kevin; Yang, Kang


    The cone-beam reconstruction theory has been proposed by Kirillov in 1961, Tuy in 1983, Feldkamp in 1984, Smith in 1985, Pierre Grangeat in 1990. The Fourier slice theorem is proposed by Bracewell 1956, which leads to the Fourier image reconstruction method for parallel-beam geometry. The Fourier slice theorem is extended to fan-beam geometry by Zhao in 1993 and 1995. By combining the above mentioned cone-beam image reconstruction theory and the above mentioned Fourier slice theory of fan-beam geometry, the Fourier slice theorem in cone-beam geometry is proposed by Zhao 1995 in short conference publication. This article offers the details of the derivation and implementation of this Fourier slice theorem for cone-beam geometry. Especially the problem of the reconstruction from Fourier domain has been overcome, which is that the value of in the origin of Fourier space is 0/0. The 0/0 type of limit is proper handled. As examples, the implementation results for the single circle and two perpendicular circle source orbits are shown. In the cone-beam reconstruction if a interpolation process is considered, the number of the calculations for the generalized Fourier slice theorem algorithm is O(N^4), which is close to the filtered back-projection method, here N is the image size of 1-dimension. However the interpolation process can be avoid, in that case the number of the calculations is O(N5).

  19. Pollen cone anatomy of Classostrobus crossii sp. nov. (Cheirolepidiaceae)

    Energy Technology Data Exchange (ETDEWEB)

    Rothwell, Gar W.; Mapes, Gene [Department of Environmental and Plant Biology, Ohio University, Athens OH 45701 (United States); Hilton, Jason [Department of Earth Sciences, School of Geography, Earth and Environmental Sciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT (United Kingdom); Hollingworth, Neville T. [Centre for Ecology and Hydrology, Winfrith Technology Centre, Winfrith Newburgh, Dorchester, Dorset, DT2 8ZD (United Kingdom)


    Discovery of a permineralized fossil cone in Mesozoic deposits of southern England provides an opportunity to document the first detailed evidence of internal pollen cone anatomy for the extinct conifer family Cheirolepidiaceae. The specimen, described here as Classostrobus crossii sp. nov., occurs in a calcareous nodule recovered from Middle Jurassic marine sediments of the Lower Callovian Sigaloceras calloviense biozone, Kellaways, near Cirencester, England. The cone is 2.0 cm long and 1.8 cm wide. Sporophylls diverge helically from the axis. Each sporophyll displays a narrow stalk and a distal lamina approx. 11 mm long that tapers to a pointed tip. There is also a basal keel that bends inward at the bottom and sides to form a shallow pocket. A single vascular bundle diverges from the cone axis, extends distally into the sporophyll stalk at the contact of two distinctly different histological zones, and further expands into the distal lamina as transfusion tracheids. Several pollen sacs are attached abaxially at the juncture of the sporophyll stalk and keel. Pollen is roughly spheroidal, 26-35 {mu}m in diameter, with unequal polar caps separated by a striated belt with a subequatorial furrow. This specimen helps clarify the range of variation in the morphology of Mesozoic conifer pollen cones. (author)

  20. Large Scale Plasmonic nanoCones array For Spectroscopy Detection

    KAUST Repository

    Das, Gobind


    Advanced optical materials or interfaces are gaining attention for diagnostic applications. However, the achievement of large device interface as well as facile surface functionalization largely impairs their wide use. The present work is aimed to address different innovative aspects related to the fabrication of large area 3D plasmonic arrays, their direct and easy functionalization with capture elements and their spectroscopic verifications through enhanced Raman and enhanced fluorescence techniques. In detail we have investigated the effect of Au-based nanoCones array, fabricated by means of direct nanoimprint technique over large area (mm2), on protein capturing and on the enhancement in optical signal. A selective functionalization of gold surfaces was proposed by using a peptide (AuPi3) previously selected by phage display. In this regard, two different sequences, labeled with fluorescein and biotin, were chemisorbed on metallic surfaces. The presence of Au nanoCones array consents an enhancement in electric field on the apex of cone, enabling the detection of molecules. We have witnessed around 12-fold increase in fluorescence intensity and SERS enhancement factor around 1.75 ×105 with respect to the flat gold surface. Furthermore, a sharp decrease in fluorescence lifetime over nanoCones confirms the increase in radiative emission (i.e. an increase in photonics density at the apex of cones).

  1. Molecular beam epitaxy of GaAs nanowires and their sustainability for optoelectronic applications. Comparing Au- and self-assisted growth methods

    Energy Technology Data Exchange (ETDEWEB)

    Breuer, Steffen


    In this work the synthesis of GaAs nanowires by molecular beam epitaxy (MBE) using the vapour-liquid-solid (VLS) mechanism is investigated. A comparison between Au- and self-assisted VLS growth is at the centre of this thesis. While the Au-assisted method is established as a versatile tool for nanowire growth, the recently developed self-assisted variation results from the exchange of Au by Ga droplets and thus eliminates any possibility of Au incorporation. By both methods, we achieve nanowires with epitaxial alignment to the Si(111) substrates. Caused by differences during nanowire nucleation, a parasitic planar layer grows between the nanowires by the Au-assisted method, but can be avoided by the self-assisted method. Au-assisted nanowires grow predominantly in the metastable wurtzite crystal structure, while their self-assisted counterparts have the zincblende structure. All GaAs nanowires are fully relaxed and the strain arising from the lattice mismatch between GaAs and Si of 4.1 % is accommodated by misfit dislocations at the interface. Self-assisted GaAs nanowires are generally found to have vertical and non-polar side facets, while tilted and polar nanofacets were described for Au-assisted GaAs nanowires. We employ VLS nucleation theory to understand the effect of the droplet material on the lateral facets. Optoelectronic applications require long minority carrier lifetimes at room temperature. We fabricate GaAs/(Al,Ga)As core-shell nanowires and analyse them by transient photoluminescence (PL) spectroscopy. The results are 2.5 ns for the self-assisted nanowires as well as 9 ps for the Au-assisted nanowires. By temperature-dependent PL measurements we find a characteristic activation energy of 77 meV that is present only in the Au-assisted nanowires. We conclude that most likely Au is incorporated from the droplets into the GaAs nanowires and acts as a deep, non-radiative recombination centre.


    Directory of Open Access Journals (Sweden)

    G. Rizzuto


    Full Text Available Foundry Alfe Chem is an industrial reality working in the field of lubrication and chemical auxiliaries for industrial processes, which falls within the framework of the emerging and increasingly important «green chemistry». The goal of the company is to develop products that are more environmentally friendly by using raw materials from renewable sources; specifically, Foundry Alfe Chem has a program of self-sustainability that contemplates, for the foreseeable future, the direct production of renewable raw materials. The company has developed a new dedicated product line, Olitema, whose purpose is to offer highly technological solutions with complete environmental sustainability. In this context, Foundry Alfe CHEM has created a new product which represents a breakthrough in the class of HFC hydraulic fluids: Ecosafe Plus is a biodegradable fire-resistant hydraulic fluid with high engineering and technological performances, high environmental sustainability and the best security guarantees in workplaces. Its formulation is glycols-free, and it allows for easier disposal of the exhausted fluid, compared to a traditional water/ glycol-based HFC hydraulic fluid. For what concern the technological properties, Ecosafe Plus has been tested by accredited laboratories with tribological trials (4 Ball wear test ASTM D 4172, Ball on disc test ASTM 6425, Brugger test DIN 51347, Vickers test ASTM D 2882, with elastomer compatibility test (ASTM D 471 and biodegradability test (OECD 310 F.

  3. Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARα(PAC) mice due to dysregulated bile acid synthesis. (United States)

    Liu, Hui-Xin; Hu, Ying; French, Samuel W; Gonzalez, Frank J; Wan, Yu-Jui Yvonne


    Peroxisome proliferator activated receptor α (PPARα) stimulates hepatocellular proliferation is species-specific. Activation of mouse, but not human, PPARα induces hepatocellular proliferation, hepatomegaly, and liver cancer. Here we tested the hypothesis that human and mouse PPARα affects liver regeneration differentially. PPARα-humanized mice (hPPARα(PAC)) were similar to wild type mice in responding to fasting-induced PPARα signaling. However, these mouse livers failed to regenerate in response to partial hepatectomy (PH). The liver-to-body weight ratios did not recover even 3 months after PH in hPPARα(PAC). The mouse PPARα-mediated down-regulation of let-7c was absent in hPPARα(PAC), which might partially be responsible for impaired proliferation. After PH, hPPARα(PAC) displayed steatosis, necrosis, and inflammation mainly in periportal zone 1, which suggested bile-induced toxicity. Quantification of hepatic bile acids (BA) revealed BA overload with increased hydrophobic BA in hPPARα(PAC). Forced FGF21 expression in partial hepatectomized hPPARα(PAC) reduced hepatic steatosis, prevented focal necrosis, and restored liver mass. Compared to mouse PPARα, human PPARα has a reduced capacity to regulate metabolic pathways required for liver regeneration. In addition, FGF21 can compensate for the reduced ability of human PPARα in stimulating liver regeneration, which suggests the potential application of FGF21 in promoting hepatic growth in injured and steatotic livers in humans.

  4. SU-F-J-205: Effect of Cone Beam Factor On Cone Beam CT Number Accuracy

    Energy Technology Data Exchange (ETDEWEB)

    Yao, W; Hua, C; Farr, J; Brady, S; Merchant, T [St. Jude Children’s Research Hospital, Memphis, TN (United States)


    Purpose: To examine the suitability of a Catphan™ 700 phantom for image quality QA of a cone beam computed tomography (CBCT) system deployed for proton therapy. Methods: Catphan phantoms, particularly Catphan™ 504, are commonly used in image quality QA for CBCT. As a newer product, Catphan™ 700 offers more tissue equivalent inserts which may be useful for generating the electron density – CT number curve for CBCT based treatment planning. The sensitometry-and-geometry module used in Catphan™ 700 is located at the end of the phantom and after the resolution line pair module. In Catphan™ 504 the line pair module is located at the end of the phantom and after the sensitometry-and-geometry module. To investigate the effect of difference in location on CT number accuracy due to the cone beam factor, we scanned the Catphan™ 700 with the central plane of CBCT at the center of the phantom, line pair and sensitometry-andgeometry modules of the phantom, respectively. The protocol head and thorax scan modes were used. For each position, scans were repeated 4 times. Results: For the head scan mode, the standard deviation (SD) of the CT numbers of each insert under 4 repeated scans was up to 20 HU, 11 HU, and 11 HU, respectively, for the central plane of CBCT located at the center of the phantom, line pair, and sensitometry-and-geometry modules of the phantom. The mean of the SD was 9.9 HU, 5.7 HU, and 5.9 HU, respectively. For the thorax mode, the mean of the SD was 4.5 HU, 4.4 HU, and 4.4 HU, respectively. The assessment of image quality based on resolution and spatial linearity was not affected by imaging location changes. Conclusion: When the Catphan™ 700 was aligned to the center of imaging region, the CT number accuracy test may not meet expectations. We recommend reconfiguration of the modules.

  5. Dysflective cones: Visual function and cone reflectivity in long-term follow-up of acute bilateral foveolitis. (United States)

    Tu, Joanna H; Foote, Katharina G; Lujan, Brandon J; Ratnam, Kavitha; Qin, Jia; Gorin, Michael B; Cunningham, Emmett T; Tuten, William S; Duncan, Jacque L; Roorda, Austin


    Confocal adaptive optics scanning laser ophthalmoscope (AOSLO) images provide a sensitive measure of cone structure. However, the relationship between structural findings of diminished cone reflectivity and visual function is unclear. We used fundus-referenced testing to evaluate visual function in regions of apparent cone loss identified using confocal AOSLO images. A patient diagnosed with acute bilateral foveolitis had spectral-domain optical coherence tomography (SD-OCT) (Spectralis HRA + OCT system [Heidelberg Engineering, Vista, CA, USA]) images indicating focal loss of the inner segment-outer segment junction band with an intact, but hyper-reflective, external limiting membrane. Five years after symptom onset, visual acuity had improved from 20/80 to 20/25, but the retinal appearance remained unchanged compared to 3 months after symptoms began. We performed structural assessments using SD-OCT, directional OCT (non-standard use of a prototype on loan from Carl Zeiss Meditec) and AOSLO (custom-built system). We also administered fundus-referenced functional tests in the region of apparent cone loss, including analysis of preferred retinal locus (PRL), AOSLO acuity, and microperimetry with tracking SLO (TSLO) (prototype system). To determine AOSLO-corrected visual acuity, the scanning laser was modulated with a tumbling E consistent with 20/30 visual acuity. Visual sensitivity was assessed in and around the lesion using TSLO microperimetry. Complete eye examination, including standard measures of best-corrected visual acuity, visual field tests, color fundus photos, and fundus auto-fluorescence were also performed. Despite a lack of visible cone profiles in the foveal lesion, fundus-referenced vision testing demonstrated visual function within the lesion consistent with cone function. The PRL was within the lesion of apparent cone loss at the fovea. AOSLO visual acuity tests were abnormal, but measurable: for trials in which the stimulus remained completely

  6. Sustainable Procurement

    DEFF Research Database (Denmark)

    Telles, Pedro; Ølykke, Grith Skovgaard


    and within it how sustainable requirements have increased the level of compliance required, particularly regulatory compliance. Compliance was already present in previous EU public procurement frameworks, but its extent on Directive 2014/24/EU leads the authors to consider the current legal framework...... as subject to substantial regulatory compliance obligations external to the process of procurement. In short, procurement has been transformed in a way to enforce regulatory obligations that are not intrinsic to the process of buying. This leads to the conclusion that questions such as the cost and trade...

  7. Prediction of transparency perception based on cone-excitation ratios (United States)

    Ripamonti, Caterina; Westland, Stephen


    Perceptual transparency was measured in two experiments by using simulations of illuminated surfaces presented on a CRT monitor. In a two-alternative forced-choice paradigm, observers viewed two simulated Mondrians in temporal sequence. In one sequence the Mondrian was simulated to be partially covered by a transparent filter; in the other sequence the filter color over each Mondrian patch was modified. Observers were instructed to select the sequence containing a transparent filter. Observers' selections corresponded to sequences in which the cone-excitation ratios for each adjacent pair of Mondrian patches were approximately the same as the cone-excitation ratios for the pair of patches covered by a filter. The results suggest that cone-excitation ratios may be a cue for perceptual transparency.

  8. Gradient angle estimation by uniform directional simulation on a cone

    DEFF Research Database (Denmark)

    Ditlevsen, Ove Dalager


    of these projections is derived assuming the limit-state surface to be a hyperplane. This distribution depends on the angle between the cone axis and the normal vector to the hyperplane. Assuming sufficient flatness of the actual limit-state surface within a neighbourhood of the cut point with the cone axis, the cone...... top angle can be chosen small enough that this distribution can be taken as the basis for the formulation of the likelihood function of the angle given the sample of projections. The angle of maximum likelihood is then the indicator of whether the cut point can be taken as a sufficiently accurate...... approximation to a locally most central limit state point. Moreover, the estimated angle can be used to correct the geometric reliability index.\\bfseries Keywords: Directional simulation, effectivity factor, gradient angle estimation, maximum likelihood, model-correction-factor method, Monte Carlo simulation...

  9. An ice-cream cone model for coronal mass ejections (United States)

    Xue, X. H.; Wang, C. B.; Dou, X. K.


    In this study, we use an ice-cream cone model to analyze the geometrical and kinematical properties of the coronal mass ejections (CMEs). Assuming that in the early phase CMEs propagate with near-constant speed and angular width, some useful properties of CMEs, namely the radial speed (v), the angular width (α), and the location at the heliosphere, can be obtained considering the geometrical shapes of a CME as an ice-cream cone. This model is improved by (1) using an ice-cream cone to show the near real configuration of a CME, (2) determining the radial speed via fitting the projected speeds calculated from the height-time relation in different azimuthal angles, (3) not only applying to halo CMEs but also applying to nonhalo CMEs.

  10. [The forms and frequency of renal parenchymal cones]. (United States)

    Kara, Murat; Tuma, Jan


    The renal parenchymal cone (RPC) is an important differential diagnosis to the real kidney tumors. It is defined as at least 15 mm large part of the normal renal parenchyma which protrudes into the space of the renal sinus. If the RPC is solely formed from renal cortical tissue, it is called "Column of Bertin" renal parenchymal cones (CB-RPC). If the renal medulla is part of RPC, together with the renal cortex, it is called lobular renal parenchymal cones (L-RPC). The aim of this prospective study was to determine the frequency of CB-RPC and the L-RPC. 200 kidneys from 100 patients were evaluated. At least one RPC was found in 53 patients. 27 RPC were on both sides. CB-RPC was present in 27,5% of the kidneys, a L-RPC in 12,5%. The high frequency of RPC underlines its importance in the diagnosis of focal renal parenchymal changes.

  11. How do horizontal cells 'talk' to cone photoreceptors? Different levels of complexity at the cone-horizontal cell synapse. (United States)

    Chapot, Camille A; Euler, Thomas; Schubert, Timm


    The first synapse of the retina plays a fundamental role in the visual system. Due to its importance, it is critical that it encodes information from the outside world with the greatest accuracy and precision possible. Cone photoreceptor axon terminals contain many individual synaptic sites, each represented by a presynaptic structure called a 'ribbon'. These synapses are both highly sophisticated and conserved. Each ribbon relays the light signal to one ON cone bipolar cell and several OFF cone bipolar cells, while two dendritic processes from a GABAergic interneuron, the horizontal cell, modulate the cone output via parallel feedback mechanisms. The presence of these three partners within a single synapse has raised numerous questions, and its anatomical and functional complexity is still only partially understood. However, the understanding of this synapse has recently evolved, as a consequence of progress in understanding dendritic signal processing and its role in facilitating global versus local signalling. Indeed, for the downstream retinal network, dendritic processing in horizontal cells may be essential, as they must support important functional operations such as contrast enhancement, which requires spatial averaging of the photoreceptor array, while at the same time preserving accurate spatial information. Here, we review recent progress made towards a better understanding of the cone synapse, with an emphasis on horizontal cell function, and discuss why such complexity might be necessary for early visual processing. © 2017 The Authors. The Journal of Physiology © 2017 The Physiological Society.

  12. Sustainable consumption and marketing

    NARCIS (Netherlands)

    Dam, van Y.K.


    Sustainable development in global food markets is hindered by the discrepancy between positive consumer attitudes towards sustainable development or sustainability and the lack of corresponding sustainable consumption by a majority of consumers. Apparently for many (light user) consumers the

  13. Organizational motifs for ground squirrel cone bipolar cells (United States)

    Light, Adam C.; Zhu, Yongling; Shi, Jun; Saszik, Shannon; Lindstrom, Sarah; Davidson, Laura; Li, Xiaoyu; Chiodo, Vince A.; Hauswirth, William W.; Li, Wei; DeVries, Steven H.


    In daylight vision, parallel processing starts at the cone synapse. Cone signals flow to On and Off bipolar cells, which are further divided into types according to morphology, immunocytochemistry, and function. The axons of the bipolar cell types stratify at different levels in the inner plexiform layer (IPL), and can interact with costratifying amacrine and ganglion cells. These interactions endow the ganglion cell types with unique functional properties. The wiring that underlies the interactions between bipolar, amacrine, and ganglion cells is poorly understood. It may be easier to elucidate this wiring if organizational rules can be established. We identify 13 types of cone bipolar cells in the ground squirrel, 11 of which contact contiguous cones with the possible exception of short-wavelength sensitive cones. Cells were identified by antibody labeling, tracer filling, and Golgi-like filling following transduction with an adeno-associated virus encoding for GFP. The 11 bipolar cell types displayed two organizational patterns. In the first pattern, 8-10 of the 11 types came in pairs with partially overlapping axonal stratification. Pairs shared morphological, immunocytochemical, and functional properties. The existence of similar pairs is a new motif that may have implications for how signals first diverge from a cone to bipolar cells, and then re-converge onto a costratifying ganglion cell. The second pattern is a mirror symmetric organization about the middle of the IPL involving at least 7 bipolar cell types. This anatomical symmetry may be associated with a functional symmetry in On and Off ganglion cell responses. PMID:22778006

  14. Spawning rings of exceptional points out of Dirac cones. (United States)

    Zhen, Bo; Hsu, Chia Wei; Igarashi, Yuichi; Lu, Ling; Kaminer, Ido; Pick, Adi; Chua, Song-Liang; Joannopoulos, John D; Soljačić, Marin


    The Dirac cone underlies many unique electronic properties of graphene and topological insulators, and its band structure--two conical bands touching at a single point--has also been realized for photons in waveguide arrays, atoms in optical lattices, and through accidental degeneracy. Deformation of the Dirac cone often reveals intriguing properties; an example is the quantum Hall effect, where a constant magnetic field breaks the Dirac cone into isolated Landau levels. A seemingly unrelated phenomenon is the exceptional point, also known as the parity-time symmetry breaking point, where two resonances coincide in both their positions and widths. Exceptional points lead to counter-intuitive phenomena such as loss-induced transparency, unidirectional transmission or reflection, and lasers with reversed pump dependence or single-mode operation. Dirac cones and exceptional points are connected: it was theoretically suggested that certain non-Hermitian perturbations can deform a Dirac cone and spawn a ring of exceptional points. Here we experimentally demonstrate such an 'exceptional ring' in a photonic crystal slab. Angle-resolved reflection measurements of the photonic crystal slab reveal that the peaks of reflectivity follow the conical band structure of a Dirac cone resulting from accidental degeneracy, whereas the complex eigenvalues of the system are deformed into a two-dimensional flat band enclosed by an exceptional ring. This deformation arises from the dissimilar radiation rates of dipole and quadrupole resonances, which play a role analogous to the loss and gain in parity-time symmetric systems. Our results indicate that the radiation existing in any open system can fundamentally alter its physical properties in ways previously expected only in the presence of material loss and gain.

  15. Knowledge Discovery for Sustainable Urban Mobility


    Momtazpour, Marjan


    Due to the rapid growth of urban areas, sustainable urbanization is an inevitable task for city planners to address major challenges in resource management across different sectors. Sustainable approaches of energy production, distribution, and consumption must take the place of traditional methods to reduce the negative impacts of urbanization such as global warming and fast consumption of fossil fuels. In order to enable the transition of cities to sustainable ones, we need to have a precis...

  16. What is Sustainable Journalism? : An introduction


    Berglez, Peter; Olausson, Ulrika; Ots, Mart


    This edited volume, which elaborates on the idea and concept of sustainable journalism, is the result of a perceived lack of integral research approaches to journalism and sustainable development. Thirty years ago, in 1987, Our Common Future, the report from the UN World Commission on Environment and Development (also known as the Brundtland Report), pointed out economic growth, environmental protection and social equality as the three main pillars of a sustainable development. These pillars ...

  17. Light-cone quantized QCD and novel hadron phenomenology

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, S.J.


    The authors reviews progress made in solving gauge theories such as collinear quantum chromodynamics using light-cone Hamiltonian methods. He also shows how the light-cone Fock expansion for hadron wavefunctions can be used to compute operator matrix elements such as decay amplitudes, form factors, distribution amplitudes, and structure functions, and how it provides a tool for exploring novel features of QCD. The author also reviews commensurate scale relations, leading-twist identities which relate physical observables to each other, thus eliminating renormalization scale and scheme ambiguities in perturbative QCD predictions.

  18. Does the Dirac Cone Exist in Silicene on Metal Substrates? (United States)

    Quhe, Ruge; Yuan, Yakun; Zheng, Jiaxin; Wang, Yangyang; Ni, Zeyuan; Shi, Junjie; Yu, Dapeng; Yang, Jinbo; Lu, Jing


    Absence of the Dirac cone due to a strong band hybridization is revealed to be a common feature for epitaxial silicene on metal substrates according to our first-principles calculations for silicene on Ir, Cu, Mg, Au, Pt, Al, and Ag substrates. The destroyed Dirac cone of silicene, however, can be effectively restored with linear or parabolic dispersion by intercalating alkali metal atoms between silicene and the metal substrates, offering an opportunity to study the intriguing properties of silicene without further transfer of silicene from the metal substrates. PMID:24969493

  19. Sustainable Happiness

    DEFF Research Database (Denmark)

    Landes, Xavier; Unger, Cindie; Andsbjerg, Kjartan

    The world Happiness report 2012, commissioned by the united nations, noted that the tools of happiness research have the potential to recast the debate between economic growth and environmental protection. Moreover, it calls for an exploration of the established links between happiness...

  20. Plant Growth Promoting Rhizobacteria

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 18; Issue 3. Plant Growth Promoting Rhizobacteria - Potential Microbes for Sustainable Agriculture. Jay Shankar Singh. General Article Volume 18 Issue 3 March 2013 pp 275-281 ...