WorldWideScience

Sample records for sustained delay-period activity

  1. Reward acts as a signal to control delay-period activity in delayed-response tasks.

    Science.gov (United States)

    Ichihara-Takeda, Satoe; Takeda, Kazuyoshi; Funahashi, Shintaro

    2010-03-31

    Prefrontal delay-period activity represents a neural mechanism for the active maintenance of information and needs to be controlled by some signal to appropriately operate working memory. To examine whether reward-delivery acts as this signal, the effects of delay-period activity in response to unexpected reward-delivery were examined by analyzing single-neuron activity recorded in the primate dorsolateral prefrontal cortex. Among neurons that showed delay-period activity, 34% showed inhibition of this activity in response to unexpected reward-delivery. The delay-period activity of these neurons was affected by the expectation of reward-delivery. The strength of the reward signal in controlling the delay-period activity is related to the strength of the effect of reward information on the delay-period activity. These results indicate that reward-delivery acts as a signal to control delay-period activity.

  2. Functions of delay-period activity in the prefrontal cortex and mnemonic scotomas revisited

    Directory of Open Access Journals (Sweden)

    Shintaro eFunahashi

    2015-02-01

    Full Text Available Working memory is one of key concepts to understand functions of the prefrontal cortex. Delay-period activity is an important neural correlate to understand the role of working memory in prefrontal functions. The importance of delay-period activity is that this activity can encode not only visuospatial information but also a variety of information including non-spatial visual features, auditory and tactile stimuli, task rules, expected reward, and numerical quantity. This activity also participates in a variety of information processing including sensory-to-motor information transformation. These mnemonic features of delay-period activity enable to perform various important operations that the prefrontal cortex participates in, such as executive controls, and therefore, support the notion that working memory is an important function to understand prefrontal functions. On the other hand, although experiments using manual versions of the delayed-response task had revealed many important findings, an oculomotor version of this task enabled us to use multiple cue positions, exclude postural orientation during the delay period, and further prove the importance of mnemonic functions of the prefrontal cortex. In addition, monkeys with unilateral lesions exhibited specific impairment only in the performance of memory-guided saccades directed toward visual cues in the visual field contralateral to the lesioned hemisphere. This result indicates that memories for visuospatial coordinates in each hemifield are processed primarily in the contralateral prefrontal cortex. This result further strengthened the idea of mnemonic functions of the prefrontal cortex. Thus, the mnemonic functions of the prefrontal cortex and delay-period activity may not need to be reconsidered, but should be emphasized.

  3. Lateralized delay period activity marks the focus of spatial attention in working memory: evidence from somatosensory event-related brain potentials.

    Science.gov (United States)

    Katus, Tobias; Eimer, Martin

    2015-04-29

    The short-term retention of sensory information in working memory (WM) is known to be associated with a sustained enhancement of neural activity. What remains controversial is whether this neural trace indicates the sustained storage of information or the allocation of attention. To evaluate the storage and attention accounts, we examined sustained tactile contralateral delay activity (tCDA component) of the event-related potential. The tCDA manifests over somatosensory cortex contralateral to task-relevant tactile information during stimulus retention. Two tactile sample sets (S1, S2) were presented sequentially, separated by 1.5 s. Each set comprised two stimuli, one per hand. Human participants memorized the location of one task-relevant stimulus per sample set and judged whether one of these locations was stimulated again at memory test. The two relevant pulses were unpredictably located on the same hand (stay trials) or on different hands (shift trials). Initially, tCDA components emerged contralateral to the relevant S1 pulse. Sequential loading of WM enhanced the tCDA after S2 was presented on stay trials. On shift trials, the tCDA's polarity reversed after S2 presentation, resulting in delay activity that was now contralateral to the task-relevant S2 pulse. The disappearance of a lateralized neural trace for the relevant S1 pulse did not impair memory accuracy for this stimulus on shift trials. These results contradict the storage account and suggest that delay period activity indicates the sustained engagement of an attention-based rehearsal mechanism. In conclusion, somatosensory delay period activity marks the current focus of attention in tactile WM. Copyright © 2015 the authors 0270-6474/15/356689-07$15.00/0.

  4. Working memory delay period activity marks a domain-unspecific attention mechanism.

    Science.gov (United States)

    Katus, Tobias; Müller, Matthias M

    2016-03-01

    Working memory (WM) recruits neural circuits that also perform perception- and action-related functions. Among the functions that are shared between the domains of WM and perception is selective attention, which supports the maintenance of task-relevant information during the retention delay of WM tasks. The tactile contralateral delay activity (tCDA) component of the event-related potential (ERP) marks the attention-based rehearsal of tactile information in somatosensory brain regions. We tested whether the tCDA reflects the competition for shared attention resources between a WM task and a perceptual task under dual-task conditions. The two tasks were always performed on opposite hands. In different blocks, the WM task had higher or lower priority than the perceptual task. The tCDA's polarity consistently reflected the hand where the currently prioritized task was performed. This suggests that the process indexed by the tCDA is not specific to the domain of WM, but mediated by a domain-unspecific attention mechanism. The analysis of transient ERP components evoked by stimuli in the two tasks further supports the interpretation that the tCDA marks a goal-directed bias in the allocation of selective attention. Larger spatially selective modulations were obtained for stimulus material related to the high-, as compared to low-priority, task. While our results generally indicate functional overlap between the domains of WM and perception, we also found evidence suggesting that selection in internal (mnemonic) and external (perceptual) stimulus representations involves processes that are not active during shifts of preparatory attention. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Stochastic Mesocortical Dynamics and Robustness of Working Memory during Delay-Period.

    Directory of Open Access Journals (Sweden)

    Melissa Reneaux

    Full Text Available The role of prefronto-mesoprefrontal system in the dopaminergic modulation of working memory during delayed response tasks is well-known. Recently, a dynamical model of the closed-loop mesocortical circuit has been proposed which employs a deterministic framework to elucidate the system's behavior in a qualitative manner. Under natural conditions, noise emanating from various sources affects the circuit's functioning to a great extent. Accordingly in the present study, we reformulate the model into a stochastic framework and investigate its steady state properties in the presence of constant background noise during delay-period. From the steady state distribution, global potential landscape and signal-to-noise ratio are obtained which help in defining robustness of the circuit dynamics. This provides insight into the robustness of working memory during delay-period against its disruption due to background noise. The findings reveal that the global profile of circuit's robustness is predominantly governed by the level of D1 receptor activity and high D1 receptor stimulation favors the working memory-associated sustained-firing state over the spontaneous-activity state of the system. Moreover, the circuit's robustness is further fine-tuned by the levels of excitatory and inhibitory activities in a way such that the robustness of sustained-firing state exhibits an inverted-U shaped profile with respect to D1 receptor stimulation. It is predicted that the most robust working memory is formed possibly at a subtle ratio of the excitatory and inhibitory activities achieved at a critical level of D1 receptor stimulation. The study also paves a way to understand various cognitive deficits observed in old-age, acute stress and schizophrenia and suggests possible mechanistic routes to the working memory impairments based on the circuit's robustness profile.

  6. Stochastic Mesocortical Dynamics and Robustness of Working Memory during Delay-Period.

    Science.gov (United States)

    Reneaux, Melissa; Gupta, Rahul; Karmeshu

    2015-01-01

    The role of prefronto-mesoprefrontal system in the dopaminergic modulation of working memory during delayed response tasks is well-known. Recently, a dynamical model of the closed-loop mesocortical circuit has been proposed which employs a deterministic framework to elucidate the system's behavior in a qualitative manner. Under natural conditions, noise emanating from various sources affects the circuit's functioning to a great extent. Accordingly in the present study, we reformulate the model into a stochastic framework and investigate its steady state properties in the presence of constant background noise during delay-period. From the steady state distribution, global potential landscape and signal-to-noise ratio are obtained which help in defining robustness of the circuit dynamics. This provides insight into the robustness of working memory during delay-period against its disruption due to background noise. The findings reveal that the global profile of circuit's robustness is predominantly governed by the level of D1 receptor activity and high D1 receptor stimulation favors the working memory-associated sustained-firing state over the spontaneous-activity state of the system. Moreover, the circuit's robustness is further fine-tuned by the levels of excitatory and inhibitory activities in a way such that the robustness of sustained-firing state exhibits an inverted-U shaped profile with respect to D1 receptor stimulation. It is predicted that the most robust working memory is formed possibly at a subtle ratio of the excitatory and inhibitory activities achieved at a critical level of D1 receptor stimulation. The study also paves a way to understand various cognitive deficits observed in old-age, acute stress and schizophrenia and suggests possible mechanistic routes to the working memory impairments based on the circuit's robustness profile.

  7. Positive periodic solutions of delayed periodic Lotka-Volterra systems

    International Nuclear Information System (INIS)

    Lin Wei; Chen Tianping

    2005-01-01

    In this Letter, for a general class of delayed periodic Lotka-Volterra systems, we prove some new results on the existence of positive periodic solutions by Schauder's fixed point theorem. The global asymptotical stability of positive periodic solutions is discussed further, and conditions for exponential convergence are given. The conditions we obtained are weaker than the previously known ones and can be easily reduced to several special cases

  8. Load-Dependent Increases in Delay-Period Alpha-Band Power Track the Gating of Task-Irrelevant Inputs to Working Memory

    Directory of Open Access Journals (Sweden)

    Andrew J. Heinz

    2017-05-01

    Full Text Available Studies exploring the role of neural oscillations in cognition have revealed sustained increases in alpha-band power (ABP during the delay period of verbal and visual working memory (VWM tasks. There have been various proposals regarding the functional significance of such increases, including the inhibition of task-irrelevant cortical areas as well as the active retention of information in VWM. The present study examines the role of delay-period ABP in mediating the effects of interference arising from on-going visual processing during a concurrent VWM task. Specifically, we reasoned that, if set-size dependent increases in ABP represent the gating out of on-going task-irrelevant visual inputs, they should be predictive with respect to some modulation in visual evoked potentials resulting from a task-irrelevant delay period probe stimulus. In order to investigate this possibility, we recorded the electroencephalogram while subjects performed a change detection task requiring the retention of two or four novel shapes. On a portion of trials, a novel, task-irrelevant bilateral checkerboard probe was presented mid-way through the delay. Analyses focused on examining correlations between set-size dependent increases in ABP and changes in the magnitude of the P1, N1 and P3a components of the probe-evoked response and how such increases might be related to behavior. Results revealed that increased delay-period ABP was associated with changes in the amplitude of the N1 and P3a event-related potential (ERP components, and with load-dependent changes in capacity when the probe was presented during the delay. We conclude that load-dependent increases in ABP likely play a role in supporting short-term retention by gating task-irrelevant sensory inputs and suppressing potential sources of disruptive interference.

  9. Work activities within sustainable development

    Directory of Open Access Journals (Sweden)

    Francisco Duarte

    2015-06-01

    Full Text Available This paper presents the main results of a Franco-Brazilian Research project entitled "Work, Innovation and Development". The aim is to conceptually consider work activity within sustainable development, and to contribute methodologically towards developing strategies for designing sustainable work systems. After a brief description of the factors and the dimensions that have contributed to the creation of ideas on sustainable development, we will put forward two main approaches for understanding work activity within the context of sustainability, these being: the durability of work activity and the development of work activities for sustainable development. Both approaches are presented and examples are given. This is followed by a discussion of the design of sustainable work systems that focuses particularly on the political and technical dimensions of project management.

  10. Active learners in sustainable electronics and it

    DEFF Research Database (Denmark)

    Schultz, Ole

    This poster-presentation is about active learning in a course sustainable wireless electronics and it. Active learning understood as practical lab-exercises and a team chosen project.......This poster-presentation is about active learning in a course sustainable wireless electronics and it. Active learning understood as practical lab-exercises and a team chosen project....

  11. Sustained apnea induces endothelial activation.

    Science.gov (United States)

    Eichhorn, Lars; Dolscheid-Pommerich, Ramona; Erdfelder, Felix; Ayub, Muhammad Ajmal; Schmitz, Theresa; Werner, Nikos; Jansen, Felix

    2017-09-01

    Apnea diving has gained worldwide popularity, even though the pathophysiological consequences of this challenging sport on the human body are poorly investigated and understood. This study aims to assess the influence of sustained apnea in healthy volunteers on circulating microparticles (MPs) and microRNAs (miRs), which are established biomarkers reflecting vascular function. Short intermittent hypoxia due to voluntary breath-holding affects circulating levels of endothelial cell-derived MPs (EMPs) and endothelial cell-derived miRs. Under dry laboratory conditions, 10 trained apneic divers performed maximal breath-hold. Venous blood samples were taken, once before and at 4 defined points in time after apnea. Samples were analyzed for circulating EMPs and endothelial miRs. Average apnea time was 329 seconds (±103), and SpO 2 at the end of apnea was 79% (±12). Apnea was associated with a time-dependent increase of circulating endothelial cell-derived EMPs and endothelial miRs. Levels of circulating EMPs in the bloodstream reached a peak 4 hours after the apnea period and returned to baseline levels after 24 hours. Circulating miR-126 levels were elevated at all time points after a single voluntary maximal apnea, whereas miR-26 levels were elevated significantly only after 30 minutes and 4 hours. Also miR-21 and miR-92 levels increased, but did not reach the level of significance. Even a single maximal breath-hold induces acute endothelial activation and should be performed with great caution by subjects with preexisting vascular diseases. Voluntary apnea might be used as a model to simulate changes in endothelial function caused by hypoxia in humans. © 2017 Wiley Periodicals, Inc.

  12. Accounting for Sustainability: An Active Learning Assignment

    Science.gov (United States)

    Gusc, Joanna; van Veen-Dirks, Paula

    2017-01-01

    Purpose: Sustainability is one of the newer topics in the accounting courses taught in university teaching programs. The active learning assignment as described in this paper was developed for use in an accounting course in an undergraduate program. The aim was to enhance teaching about sustainability within such a course. The purpose of this…

  13. Banking Activity for Sustainable Development

    Directory of Open Access Journals (Sweden)

    Ion Stancu

    2006-08-01

    Full Text Available he corporations gain a power of influence, unthinkable years ago; they have acquired more and more rights and, in some way, govern the life of billions of peoples and of the earth in general. With every right, comes though the responsibility of the conservation and development of the environment in which the corporations act. The banking system has a major role to play in the evolution of the international framework, given its position on the economic stage. Some important banking groups realized this fact and made important steps in the area. The case study of the Holland banking group ABN AMRO proves the complexity of the introduction of sustainable development in the core of the financial business. The implementation is neither easy nor cheap. It implies essential changes in the bank management, in the way to determine the financial policies, in how to choose the clients, the employees, the suppliers etc. Led in an efficient way, sustainable banking implies innovation, creativity and, implicitly, new gains, through creating new products and opening new markets. The international banking community proved, through leading examples (ABN AMRO Bank, HSBC Group, Rabobank Group, JP Morgan Chase, Citigroup etc. that it understands the importance, the necessity and also the viability of the sustainable development.

  14. Coal and sustainable development: utilities and activity

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Reflecting its continuing focus on coal and sustainable development, the CIAB surveyed its Members about their attitudes to sustainable development and to obtain information on sustainable development activities within their organisations. The survey revealed that awareness of the importance of sustainable development has increased significantly in the past three years, with a clear majority of respondents seeing it as aligning with their commercial objectives. Reducing emissions from coal use is seen as the key priority, although the importance of this relative to other priorities varies on a regional basis depending on local circumstances. While a large majority of respondents recognised the importance of sustainable development and its increasing influence on decision-making within the coal industry, there was a wide range in the extent of activities. Some organisations have embarked on broad initiatives to better align their practices to sustainable development priorities. The range of activities suggests an evolutionary process - one that commences with a sole internal focus on economic priorities for the business, and then broadens to include local environmental issues and the community. Leading organisations are now moving to look more at global issues, to recognise and share the responsibility for the social and environmental impacts of producing and using their products, and to better engage stakeholders. 4 figs.

  15. Experimental and numerical assessment of ignition delay period for pure diesel and biodiesel B20

    Science.gov (United States)

    Aldhaidhawi, Mohanad; Brabec, Marek; Lucian, Miron; Chiriac, Radu; Bădescu, Viorel

    2017-10-01

    The ignition delay period for a compression ignition engine fueled alternatively with pure diesel and with biodiesel B20 has been experimentally and numerically investigated. The engine was operated under full load conditions for two speeds, 1400 rpm speed for maximum brake torque and 2400 rpm speed for maximum brake power. Different parameters suggested as important to define the start of combustion have been considered before the acceptance of a certain evaluation technique of ignition delay. Correlations between these parameters were analyzed and concluded about the best method to identify the start of combustion. The experimental results were further compared with the ignition delay predicted by some correlations. The results showed that the determined ignition delays are in good agreement with those of the Arrhenius type expressions for pure diesel fuel, while for biodiesel B20 the correlation results are significantly different than the experimental results.

  16. Advancing a sustainable highway system : highlights of FHWA sustainability activities

    Science.gov (United States)

    2014-06-01

    FHWA is undertaking a significant amount of work related to sustainability across a number of program areas throughout the Agency. The purpose of this report is to showcase some of the ways in which FHWA is incorporating and embedding sustainability ...

  17. Active living by design sustainability strategies.

    Science.gov (United States)

    Kraft, M Katherine; Lee, Joanne J; Brennan, Laura K

    2012-11-01

    Despite substantial increases in improving the translation of health promotion research into practice, community initiatives still struggle with maintaining changes once grant funding has ended. Researchers, funders, and community practitioners are interested in practices that maintain and sustain their efforts. This qualitative study conducted a content analysis of evaluation findings from Active Living by Design (ALbD) to identify activities that community coalitions implemented to maintain their initiative and secure ongoing influence in communities. Investigators analyzed data from interviews, focus groups, and the Progress Reporting System to identify sustainability approaches clustering into five areas: partnership expansion, sustainable funding, permanent advisory committees, policy change, and institution/organization change. Partnership expansion occurred across sectors and disciplines and into broader geographic areas. Additional funding extended beyond grants to earned income streams and dedicated tax revenues. Permanent advisory committees were established to inform decision makers about a range of active living impacts. Policy changes in zoning and comprehensive plans ensured maintenance of health-promoting built environments. Sustainability through institution/organization changes led to allocation of dedicated staff and incorporation of active living values into agency missions. Active Living by Design partnerships defined and messaged their projects to align with policymakers' interests and broad partnership audiences. They found innovative supporters and adapted their original vision to include quality of life, nonmotorized transport, and other complementary efforts that expanded their reach and influence. These sustainability strategies altered awareness within communities, changed community decision-making processes, and created policy changes that have the potential to maintain environments that promote physical activity for years to come

  18. EDF Group: activity and sustainable development 2010

    International Nuclear Information System (INIS)

    2010-01-01

    After a map illustrating the worldwide dimension of EDF, and an interview of the EDF's chairman, this report presents and comments some sustainable development indicators for EDF activity in 2010. Then, after a presentation of the world energy context, it presents and comments EDF's main activities: energy production and engineering, network management, trading. It presents and comments the operational performance of the company in different countries (France, United Kingdom, Italy, and other countries) and evokes additional activities. The next chapter deals with human resources and with innovation and R and D activities. The last chapter presents governance structures and financial results

  19. ANDRA - Activity and sustainable development report 2011

    International Nuclear Information System (INIS)

    Dupuis, Marie-Claude; Gonnot, Francois-Michel; Renauld, Valerie; Sanz, Carole

    2012-07-01

    This annual report addresses the following aspects: governance (missions, localizations, institutional partners, clients, Meuse/Haute-Marne land planning scheme, underground research laboratory, Cigeo project), human resources (accident prevention, salaried personnel, customer relationship management, next steps for the Cigeo project), public service missions (polluted sites, waste confinement in Pargny-sur-Saulx, the radium diagnosis operation, a remote declaration as a new service to prepare the national inventory for 2012), industrial activities (the industrial design phase of the Cigeo project, the Manche storage centre, the Aube storage centre), environmental activities (the Observatory of the environment, the weak impact of the storage centres, the evolution of analysis laboratory of the industrial directorate), scientific policy, technological researches, experiments and developments, international activity and relationships, sustainable development, dialogue, transparency and communication, future generations, and prospective

  20. The young and active travellers' attitudes towards sustainable leisure tourism

    OpenAIRE

    Lindholm, Lauha

    2016-01-01

    This bachelor thesis studies the travellers’ attitudes towards sustainable tourism. Due to the size of the topic a limitation was made to specify in young and active travellers attitudes and moreover to focus on the leisure tourism. Sustainability is a hot topic in all fields of business but it is not yet a standard. Sustainable business is business that takes the future in notice. Considering the fast growth of the tourism industry, sustainable development will be necessary and needed. ...

  1. Experimental investigations of ignition delay period and performance of a diesel engine operated with Jatropha oil biodiesel

    Directory of Open Access Journals (Sweden)

    Mohammed EL-Kasaby

    2013-06-01

    Full Text Available Jatropha-curcas as a non-edible methyl ester biodiesel fuel source is used to run single cylinder, variable compression ratio, and four-stroke diesel engine. Combustion characteristics as well as engine performance are measured for different biodiesel – diesel blends. It has been shown that B50 (50% of biodiesel in a mixture of biodiesel and diesel fuel gives the highest peak pressure at 1750 rpm, while B10 gives the highest peak pressure at low speed, 1000 rpm. B50 shows upper brake torque, while B0 shows the highest volumetric efficiency. B50 shows also, the highest BSFC by about (12.5–25% compared with diesel fuel. B10 gives the highest brake thermal efficiency. B50 to B30 show nearly the lowest CO concentration, besides CO concentration is the highest at both idle and high running speeds. Exhaust temperature and NOx are maximum for B50. Delay period is measured and correlated for different blends. Modified empirical formulae are obtained for each blend. The delay period is found to be decreased with the increase of cylinder pressure, temperature and equivalence ratio.

  2. Transforming Sustainability Development Education in Malaysian Schools through Greening Activities

    Science.gov (United States)

    Hanifah, Mahat; Shaharudin, Idrus; Mohmadisa, Hashim; Nasir, Nayan; Yazid, Saleh

    2015-01-01

    This article aims to evaluate the practice of sustainability among Malaysian Secondary Schools involved in the Sustainable Schools Program Environmental Award (SLAAS). The research attempts to identify the SLAAS effects on teachers' and students' behaviors after direct involvement with the activities of the program. The cluster sampling technique…

  3. Complex psycho-pharma-correction at the delayed period of irradiation

    International Nuclear Information System (INIS)

    Aliev, D.I.; Alieva, I.N.; Guliyev, M.M.

    2002-01-01

    High therapeutic efficiency of new approach at the complex neuro-psycho-pharma-correction of the patients with acute astenic-depressive states induced by irradiation during the liquidation of the Chernobyl Nuclear Power Plant damages has been reported. The patients with diencephal paroxysms at the remote period of irradiation (from 100 to 200 rad) were treated. The method is based on the regulation of the intracellular regulatory enzymes, i.e. adenylate- and guanylate cyclases (AC and GC, accordingly) by specific combination of NO-producing medicines (Sulpiride, Chlonazepam and Nitrazepam), Fe 2+ - containing preparations (Ferro-plex and Ferro-sulphate) and Caffeine. Both enzymes, catalyzed the synthesis and accumulation into cell of cyclic nucleotides, cAMP and cGMP. The main activator of the AC is Caffeine. GC is stimulated by nitrogen oxide (NO) molecules. The mechanism of biological effect of NO is based on its ability to bind to the heme component of GC and to initiate the conformational reorganization of the protein's three-dimensional structure and the enzyme functional activity. As a source of endogenous NO, the Sulpiride, Chlonazepam and Nitrazepam are used. In the given work we submit the clinical data confirming the efficiency of the approach used by us. For this purpose 60 patients (of the average catamnesis 4.1 years) are selected. They are divided into two groups. The first group consists of 30 patients treated by NO-producing medicines (Sulpiride, Chlonazepam and Nitrazepam) and traditionally using antidepressants, small antipsychotic drugs and etc. The second group consists of patients treated by antidepressant in complex with Fe 2+ - consisting preparations. According to the clinical data and comparative analysis with other methods one allows to achieve positive therapeutic result in short period (about 1.5 time less) and create more stable remission

  4. Sustainability.

    Science.gov (United States)

    Chang, Chein-Chi; DiGiovanni, Kimberly; Mei, Ying; Wei, Li

    2016-10-01

    This review on Sustainability covers selected 2015 publications on the focus of Sustainability. It is divided into the following sections : • Sustainable water and wastewater utilities • Sustainable water resources management • Stormwater and green infrastructure • Sustainability in wastewater treatment • Life cycle assessment (LCA) applications • Sustainability and energy in wastewater industry, • Sustainability and asset management.

  5. ANDRA - 2012 activity and sustainable development report

    International Nuclear Information System (INIS)

    Renauld, Valerie; Levert, Anne-Sophie; Muzerelle, Sophie; Cassoli, Emmanuel

    2013-07-01

    After a brief presentation of the main events during 2012, a recall of the ANDRA's mission (national inventory of radioactive materials and wastes), and a brief presentation of staffing data, this report presents and comments the activities of the ANDRA in the industrial domain (the Cigeo project for deep geological disposal of radioactive wastes, activities of the Aube centres and of the Manche storage centre, perspectives for low-activity long-life wastes, decontamination of polluted sites), in the scientific field (European projects, support to education and training, participation to a colloquium on clays, activities in the field of numerical simulation, activities of the 'Observatoire de l'Environnement'). The next part address the international activities, local commitments (in relationship with the different storage and industrial centres, or in the field of education and training), and activities related to communication and information

  6. Sustainable Buildings. Using Active Solar Power

    Energy Technology Data Exchange (ETDEWEB)

    Sharp, M. Keith [Univ. of Louisville, KY (United States); Barnett, Russell [Univ. of Louisville, KY (United States)

    2015-04-20

    The objective of this project is to promote awareness and knowledge of active solar energy technologies by installing and monitoring the following demonstration systems in Kentucky: 1) Pool heating system, Churchill Park School, 2) Water heating and daylighting systems, Middletown and Aiken Road Elementary Schools, 3) Photovoltaic street light comparison, Louisville Metro, 4) up to 25 domestic water heating systems across Kentucky. These tasks will be supported by outreach activities, including a solar energy installer training workshop and a Kentucky Solar Energy Conference.

  7. Challenges for sustainability of home based economic activities in ...

    African Journals Online (AJOL)

    Factors accountable for successful and sustainable home based economic activities were determined. Impacts of home based economic activities were found to be significant in the education of the children, income security and social welfare of families. The study emphasized home economic entrepreneurial education, ...

  8. Building Better Buildings: Sustainable Building Activities in California Higher Education Systems.

    Science.gov (United States)

    Sowell, Arnold; Eichel, Amanda; Alevantis, Leon; Lovegreen, Maureen

    2003-01-01

    This article outlines the activities and recommendations of California's sustainable building task force, discusses sustainable building activities in California's higher education systems, and highlights key issues that California is grappling with in its implementation of sustainable building practices. (EV)

  9. Sustainable Transportation Systems Research Group: Ongoing and Past Activities

    OpenAIRE

    Gkritza, Konstantina "Nadia"; Hurtado, Davis Chacon; Gkartzonikas, Christos; Ke, Yue; Losada, Lisa L

    2017-01-01

    This presentation describes the ongoing and past activities of the Sustainable Transportation Systems Research (STSR) group at Purdue University (https://engineering.purdue.edu/STSRG). The STSR group aims to achieve green, safe, efficient, and equitable transportation systems by studying and modeling transportation externalities, using state of the art statistical, econometric, and economic analysis tools.

  10. Sustainable production of biologically active molecules of marine based origin.

    Science.gov (United States)

    Murray, Patrick M; Moane, Siobhan; Collins, Catherine; Beletskaya, Tanya; Thomas, Olivier P; Duarte, Alysson W F; Nobre, Fernando S; Owoyemi, Ifeloju O; Pagnocca, Fernando C; Sette, L D; McHugh, Edward; Causse, Eric; Pérez-López, Paula; Feijoo, Gumersindo; Moreira, Ma T; Rubiolo, Juan; Leirós, Marta; Botana, Luis M; Pinteus, Susete; Alves, Celso; Horta, André; Pedrosa, Rui; Jeffryes, Clayton; Agathos, Spiros N; Allewaert, Celine; Verween, Annick; Vyverman, Wim; Laptev, Ivan; Sineoky, Sergei; Bisio, Angela; Manconi, Renata; Ledda, Fabio; Marchi, Mario; Pronzato, Roberto; Walsh, Daniel J

    2013-09-25

    The marine environment offers both economic and scientific potential which are relatively untapped from a biotechnological point of view. These environments whilst harsh are ironically fragile and dependent on a harmonious life form balance. Exploitation of natural resources by exhaustive wild harvesting has obvious negative environmental consequences. From a European industry perspective marine organisms are a largely underutilised resource. This is not due to lack of interest but due to a lack of choice the industry faces for cost competitive, sustainable and environmentally conscientious product alternatives. Knowledge of the biotechnological potential of marine organisms together with the development of sustainable systems for their cultivation, processing and utilisation are essential. In 2010, the European Commission recognised this need and funded a collaborative RTD/SME project under the Framework 7-Knowledge Based Bio-Economy (KBBE) Theme 2 Programme 'Sustainable culture of marine microorganisms, algae and/or invertebrates for high value added products'. The scope of that project entitled 'Sustainable Production of Biologically Active Molecules of Marine Based Origin' (BAMMBO) is outlined. Although the Union is a global leader in many technologies, it faces increasing competition from traditional rivals and emerging economies alike and must therefore improve its innovation performance. For this reason innovation is placed at the heart of a European Horizon 2020 Strategy wherein the challenge is to connect economic performance to eco performance. This article provides a synopsis of the research activities of the BAMMBO project as they fit within the wider scope of sustainable environmentally conscientious marine resource exploitation for high-value biomolecules. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Activity-based Sustainability Assessment of Highly Automated Manufacturing

    DEFF Research Database (Denmark)

    Rödger, Jan-Markus; Bey, Niki; Alting, Leo

    Sustainability of technology is a multifaceted endeavor and a main requirement from industry is to make it a profitable business case with clearly defined targets. To achieve that, a new assessment framework and applicable method [1] is presented which has been developed closely with industry. It.......g. “transportation”) down to smallest production units by using activity-based target setting in a consistent way to lowers risks in the planning phase of products and production....

  12. Cognitive Neurostimulation: Learning to Volitionally Sustain Ventral Tegmental Area Activation.

    Science.gov (United States)

    MacInnes, Jeff J; Dickerson, Kathryn C; Chen, Nan-Kuei; Adcock, R Alison

    2016-03-16

    Activation of the ventral tegmental area (VTA) and mesolimbic networks is essential to motivation, performance, and learning. Humans routinely attempt to motivate themselves, with unclear efficacy or impact on VTA networks. Using fMRI, we found untrained participants' motivational strategies failed to consistently activate VTA. After real-time VTA neurofeedback training, however, participants volitionally induced VTA activation without external aids, relative to baseline, Pre-test, and control groups. VTA self-activation was accompanied by increased mesolimbic network connectivity. Among two comparison groups (no neurofeedback, false neurofeedback) and an alternate neurofeedback group (nucleus accumbens), none sustained activation in target regions of interest nor increased VTA functional connectivity. The results comprise two novel demonstrations: learning and generalization after VTA neurofeedback training and the ability to sustain VTA activation without external reward or reward cues. These findings suggest theoretical alignment of ideas about motivation and midbrain physiology and the potential for generalizable interventions to improve performance and learning. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Orientation of sustainable management of chemical company with international activity

    Directory of Open Access Journals (Sweden)

    Valéria da Veiga Dias

    2013-04-01

    Full Text Available The search for new business possibilities, either through international activities and capture niche markets appear as a distinct trend among organizations that target growth. For this growing number of organizations intent on investing in new issues related to values such as citizenship, ethics and environmental concerns. There is the adoption of a more responsive to the community or even the acceptance of responsibility for the impacts of their production processes, inserting themselves in what was initially called the Social Responsibility within the business context and developed the concept of Elkington (1998 generated a discussion about a new movement that was called a sustainable paradigm. It was observed generally that sustainable management is still very close to supporting tools and not as part of the construction of corporate strategy although it is possible to realize that they seek a greater involvement in this direction when they start to review their strategies. This question can be perceived at different levels between the companies, but which shows the issue is the lack of direct indicators for investment and sustainable return. Sustainable management proved to be a source of opportunity for overseas business for the companies studied, as preparation for work with environmental legislation, global requirements, raw materials and environmentally friendly processes organizations prepared to market in the global sphere, and Brazil note that the innovative products for their production process and / or alternative raw material still do not get the spotlight. Acting in a sustainable manner enables the development of strategies agreed with conscious posture and changes in cultural terms in general, which can create new opportunities for those who can keep up with the global business scenario.

  14. Active postoperative acromegaly: sustained remission after discontinuation of somatostatin analogues

    Directory of Open Access Journals (Sweden)

    Cristina Alvarez-Escola

    2016-11-01

    Full Text Available In patients with active acromegaly after pituitary surgery, somatostatin analogues are effective in controlling the disease and can even be curative in some cases. After treatment discontinuation, the likelihood of disease recurrence is high. However, a small subset of patients remains symptom-free after discontinuation, with normalized growth hormone (GH and insulin-like growth factor (IGF1 levels. The characteristics of patients most likely to achieve sustained remission after treatment discontinuation are not well understood, although limited evidence suggests that sustained remission is more likely in patients with lower GH and IGF1 levels before treatment withdrawal, in those who respond well to low-dose treatment, in those without evidence of adenoma on an MRI scan and/or in patients who receive long-term treatment. In this report, we describe the case of a 56-year-old female patient treated with lanreotide Autogel for 11 years. Treatment was successfully discontinued, and the patient is currently disease-free on all relevant parameters (clinical, biochemical and tumour status. The successful outcome in this case adds to the small body of literature suggesting that some well-selected patients who receive long-term treatment with somatostatin analogues may achieve sustained remission.

  15. Sustainability of a physical activity and nutrition program for seniors.

    Science.gov (United States)

    Pasalich, M; Lee, A H; Jancey, J; Burke, L; Howat, P

    2013-01-01

    This prospective cohort study aimed to determine the impact of a low cost, home-based physical activity and nutrition program for older adults at 6 months follow-up. A follow-up survey was conducted 6 months after program completion via computer-assisted telephone interviewing. The International Physical Activity Questionnaire and the Fat and Fibre Barometer were used to measure physical activity levels and dietary behaviours, respectively. Self-reported height, weight, waist and hip circumferences were obtained. Changes over three time points of data collection (baseline, post-program, follow-up) and differences between the intervention and control groups were assessed. The use of program materials was also evaluated. Community and home-based. Insufficiently active 60 to 70 year olds (n = 176, intervention and n = 198, control) residing in suburbs within the Perth metropolitan area. A sustained improvement was observed for the intervention group in terms of fat avoidance behaviours (p interaction = .007). Significant improvements were found for strength exercises, fibre intake, body mass index and waist-to-hip ratio at either post-program or follow-up, however the overall effect was not significant. At post-program, the intervention group increased time spent participating in moderate activity by 50 minutes (p > .05), which was followed by a significant decline at follow-up (p nutrition intervention resulted in a sustained improvement in fat avoidance behaviours and overall short-term gains in physical activity. Future studies for older adults are recommended to investigate gender-specific behavioural barriers as well as booster interventions which focus on physical activity.

  16. Education for sustainable development using indoor and outdoor activities

    Science.gov (United States)

    Žigon, Lenka

    2016-04-01

    Environmental education became an important part of our development in the last years. We put a lot of effort into a task how to improve students'values, skills, understanding and how to significantly enhance their learning and achievements regarding ecological problems. At the same time we also know that environmental learning is easier when our students have the opportunity to feel, see, touch, taste and smell the nature. Therefore teachers in my school develop regular access to the outdoors as a learning resource. Students understand the impact of their activities on the environment and they also like to participate in the nature protection. My school (Biotechnical Centre)is an example of educational centre where different research and development programes are strongly oriented to the sustainable development. Students are educated to become experts in biotechnology, agronomy, food technology and horticulture. At the same time they are educated how to care for the nature. The institution itself cooperates with different fields of economy (farms, food - baker industry, floristry, country design etc.). For these reasons the environmental education is an essential dimension of basic education focused on a sphere of interaction that lies at the root of personal and social development. We try to develop different outdoor activities through all the school year. These activities are: analyse the water quality; research waste water treatment plants; exploration of new food sources (like aquaponics - where fish and plants grow together); collecting plants with medical activities; care for the plants in the school yard; growing new plants in the poly tunnel; learning about unknown plants - especially when visiting national and regional parks; selling different things in the school shop - also for local citizens; participating in the world wide activity - "Keep the country tidy" etc. Students and teachers enjoy to participate in different outdoor activities; we both

  17. Nuclear technology for sustainable development and FNCA activities

    International Nuclear Information System (INIS)

    Machi, Sueo

    2004-01-01

    Nuclear techniques have been contributing to sustainable development and human welfare through their applications in agriculture, health care, food supply, industry, water resources and environmental conservation. Nuclear techniques are more advantageous and/or complementary with other techniques to achieve goals. For many applications nuclear technique is more environmentally friendly because it does not need chemical agents to induce necessary reactions. This paper also illustrates successful applications of nuclear techniques and activities of the regional nuclear cooperation in Asia, FNCA (Forum for Nuclear Cooperation in Asia) to achieve common goals with limited resources. (author)

  18. Public Policy Environment: legalization and judicial activism for sustainable development

    Directory of Open Access Journals (Sweden)

    Belinda Pereira da Cunha

    2017-04-01

    Full Text Available This article analyzes the phenomenon of judicialization of environmental public policies, from the "lens" judicial activism, making sure that we can include the existence of this phenomenon in the treatment of these policies. In our post-modern era we have seen increasingly the role of the judiciary. Thus, it sought to address this issue of judicial activism against such contemporary issues as the environment, seeking to understand how the judiciary behaves in relation to environmental issues, which no longer has time to waive or give up the protection of natural resources and compliance with the principle of sustainable development. The methodology used was a literature review and secondary data collection. It was noticed a different activism in the face of environmental issues.

  19. Towards a new paradigm: Activity level balanced sustainability reporting.

    Science.gov (United States)

    Samudhram, Ananda; Siew, Eu-Gene; Sinnakkannu, Jothee; Yeow, Paul H P

    2016-11-01

    Technoeconomic paradigms based economic growth theories suggest that waves of technological innovations drove the economic growth of advanced economies. Widespread economic degradation and pollution is an unintended consequence of such growth. Tackling environmental and social issues at firm levels would help us to overcome such issues at macro-levels. Consequently, the Triple Bottom Line (TBL) reporting approach promotes firm level economic, environmental and social performances. Incorporating Zink's (2014) 3-pillar presentation model, this paper indicates that economic, social and environmental performances tend to be reported at firm level. All three pillars are not covered evenly at the activity levels. Thus, a loophole is identified whereby excellent environmental performance at activity levels could potentially leave poor social performance undisclosed. A refinement of the TBL paradigm, whereby all three pillars are covered at the activity level, is suggested, to enhance sustainability reporting. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. A theory of working memory without consciousness or sustained activity

    Science.gov (United States)

    Trübutschek, Darinka; Marti, Sébastien; Ojeda, Andrés; King, Jean-Rémi; Mi, Yuanyuan; Tsodyks, Misha; Dehaene, Stanislas

    2017-01-01

    Working memory and conscious perception are thought to share similar brain mechanisms, yet recent reports of non-conscious working memory challenge this view. Combining visual masking with magnetoencephalography, we investigate the reality of non-conscious working memory and dissect its neural mechanisms. In a spatial delayed-response task, participants reported the location of a subjectively unseen target above chance-level after several seconds. Conscious perception and conscious working memory were characterized by similar signatures: a sustained desynchronization in the alpha/beta band over frontal cortex, and a decodable representation of target location in posterior sensors. During non-conscious working memory, such activity vanished. Our findings contradict models that identify working memory with sustained neural firing, but are compatible with recent proposals of ‘activity-silent’ working memory. We present a theoretical framework and simulations showing how slowly decaying synaptic changes allow cell assemblies to go dormant during the delay, yet be retrieved above chance-level after several seconds. DOI: http://dx.doi.org/10.7554/eLife.23871.001 PMID:28718763

  1. Sustainability Smarts: Best Practices for College Unions and Student Activities

    Science.gov (United States)

    Stringer, Elizabeth

    2008-01-01

    Colleges and universities around the world are enacting sustainable initiatives. Some are signing the American College and University President's Climate Committment, while others are being recognized by STARS (Sustainability, Tracking, Assessment, & Rating System). Despite what level of dedication to sustainability an institution might have, it…

  2. Polycomb-group genes sustaining the stem cell activity

    International Nuclear Information System (INIS)

    Takihara, Yoshihiro

    2006-01-01

    Polycomb-group genes (PcG) have a role in constituting the cellular memory mechanisms through which the once expressed phenotypes during development are transmitted thereafter and this review describes, together with authors' findings of sustaining hematopoietic stem cell activity by the PcG products, what molecular bases, involving the control of histone code, are concerned in the memory. Recent investigations have gradually elucidated the outline of epigenetic control mechanisms of the memory: messages are set up as a histone code in the chromatin and the PcG complex recruited by recognition of the code regulates the chromatin structure leading to DNA transcription and maintenance of the phenotype. Proliferation of hematopoietic stem cells ex vivo will be possible if exact and detailed mechanisms for PcG are made clear in future. Such ex vivo techniques are especially awaited for marrow remodeling treatment of hematopoietic failure induced by radiation exposure. (T.I.)

  3. Integrating Sustainability into the Marketing Curriculum: Learning Activities that Facilitate Sustainable Marketing Practices

    Science.gov (United States)

    Borin, Norm; Metcalf, Lynn

    2010-01-01

    In response to political, social, and competitive forces, many firms are developing sustainable marketing strategies. Marketing educators can play an important role in assisting these firms by developing curricula that build the knowledge and skills required to enable marketing graduates to contribute to sustainable marketing efforts. Marketing…

  4. Sustainability and Science Learning: Perceptions from 8th Grade Students Involved with a Role Playing Activity

    Science.gov (United States)

    Freire, Sofia; Baptista, Mónica; Freire, Ana

    2016-01-01

    Raising awareness about sustainability is an urgent need and as such education for sustainability has gained relevancy for the last decades. It is acknowledged that science education can work as an important context for educating for sustainability. The goal of the present paper is to describe a role-playing activity about the construction of a…

  5. The Necessity of Public Relations for Sustainable Mining Activities

    Science.gov (United States)

    Lee, Hyunbock; Ji, Sangwoo

    2015-04-01

    This paper reports research about the necessity of image making for sustainable mine developments in the Republic of Korea. One of the big risks in mining activities is mining area residents opposing mine developments and operations. Analysis of the media reports on disputes between mining companies and residents can determine causes of opposing mine developments, dispute process, and influences of disputes on processes of mining projects. To do this, civil complaints from 2009 to 2012 and 24 media reports since 2000 on opposing mining activities are analyzed. And, to analyze difficulties of mining companies, the survey is conducted to target to mining companies. 57 representatives of mining companies are participated in the survey. The result of analysis cited that the major reasons of anti-mining activities are environmental degradation and reduced agricultural productivity. And specifically because of water pollution (50%), crop damages (33%), and mining dust pollution (21%), communities of mining area are against mine developments and operations. However, 25% of residents have experience of the damage caused by mining activities and the remaining 75% of residents opposing mining activities simply have anxiety about mining pollution. In the past, construction-oriented, environment-unfriendly mining projects had lasted. And while mine reclamation had been postponed in abandoned mines, mining area residents had suffered from mining pollution. So, mining area residents are highly influenced by the prejudice that mining activities are harmful to mining area communities. Current mining projects in South Korea, unlike the past mining activity, focus on minimizing environmental damage and contributing to mining area communities financially. But, in many case of disputes between mining companies and mining area residents, the both cannot reach an agreements because of the negative prejudice. Moreover, some communities categorically refuse any mining activity. On the

  6. Task-irrelevant distractors in the delay period interfere selectively with visual short-term memory for spatial locations.

    Science.gov (United States)

    Marini, Francesco; Scott, Jerry; Aron, Adam R; Ester, Edward F

    2017-07-01

    Visual short-term memory (VSTM) enables the representation of information in a readily accessible state. VSTM is typically conceptualized as a form of "active" storage that is resistant to interference or disruption, yet several recent studies have shown that under some circumstances task-irrelevant distractors may indeed disrupt performance. Here, we investigated how task-irrelevant visual distractors affected VSTM by asking whether distractors induce a general loss of remembered information or selectively interfere with memory representations. In a VSTM task, participants recalled the spatial location of a target visual stimulus after a delay in which distractors were presented on 75% of trials. Notably, the distractor's eccentricity always matched the eccentricity of the target, while in the critical conditions the distractor's angular position was shifted either clockwise or counterclockwise relative to the target. We then computed estimates of recall error for both eccentricity and polar angle. A general interference model would predict an effect of distractors on both polar angle and eccentricity errors, while a selective interference model would predict effects of distractors on angle but not on eccentricity errors. Results showed that for stimulus angle there was an increase in the magnitude and variability of recall errors. However, distractors had no effect on estimates of stimulus eccentricity. Our results suggest that distractors selectively interfere with VSTM for spatial locations.

  7. Application of nuclear technology for sustainable development, and IAEA activities

    International Nuclear Information System (INIS)

    Machi, Sueo

    1998-01-01

    The role of radiation and isotopes for sustainable development in improving agriculture, industry and environmental conservation is presented. The radiation and isotope technology can increase productivity in a sustainable way. The IAEA programmes encompass mutation breeding, soil fertility and crop production, animal production, food irradiation, agrochemicals and insect pest control using nuclear technology

  8. Classroom Active Learning Complemented by an Online Discussion Forum to Teach Sustainability

    Science.gov (United States)

    Dengler, Mary

    2008-01-01

    This paper identifies some of the pedagogical benefits of an active learning course delivery complemented by an online discussion forum to teach sustainability by evaluating the case of a geography master's course. The potential benefits and some challenges of an active learning course delivery to teach sustainability in geography and related…

  9. Participatory processes and institutional debate activities as key complementary aspects for embedding sustainability in higher education

    OpenAIRE

    Esteban, F.; Ferrer Balas, Dídac; Barceló García, Miquel

    2008-01-01

    Introducing sustainable development into educational programs of universities tend to be approached under two complementary strategies: “top-down” and “bottom-up”. Top-down strategies promote the adaptation of the institutional framework to the new challenges that sustainable development generates into technical expertise areas. Bottom-up strategies focus on institutional activities oriented to convincing or supporting lecturers in integrating sustainable development in their d...

  10. Adaptations of upper trapezius muscle activity during sustained contractions in women with fibromyalgia

    DEFF Research Database (Denmark)

    Falla, Deborah Lorraine; Andersen, Helle; Danneskiold-Samsøe, Bente

    2010-01-01

    a topographical map of the distribution of muscle activity. The pain level rated by the patients at the beginning of the sustained contraction was 5.9+/-1.5. The peak pain intensity for the control group following the injection of hypertonic saline was 6.0+/-1.6. During the sustained contractions, the EMG...

  11. Standardization by ISO to Ensure the Sustainability of Space Activities

    Science.gov (United States)

    Kato, A.; Lazare, B.; Oltrogge, D.; Stokes, H.

    2013-08-01

    The ISO / Technical Committee 20 / Sub-committee 14 develops debris-related standards and technical reports to mitigate debris and help ensure mission and space sustainability. While UN Guidelines and the IADC Guidelines encourage national governments and agencies to promote debris mitigation design and operation, the ISO standards will help the global space industry promote and sustain its space-related business. In this paper the scope and status of each ISO standard is discussed within an overall framework. A comparison with international guidelines is also provided to demonstrate the level of consistency. Finally, as a case study, the ISO standards are applied to a CubeSat mission, thus demonstrating their usability on a relatively recent and popular class of satellite.

  12. Is Environmental Dematerialization An Active Factor Of The Sustainable Development?

    Directory of Open Access Journals (Sweden)

    Florin Razvan BĂLĂȘESCU

    2012-09-01

    Full Text Available As it is known, sustainable development reveals economic, social and ecologic aspects circumscribed to the sustainability of the stock of natural capital and to the energy matter entropic flows which affects the relation environment-economy-society in terms of externalities and of the socio-industrial metabolism. Thus, taking into account the principles of the technical-economic rationality and integrative socio-ecologic complexity, dematerialization is a concept, an instrument and a vector carrying socio-economic values based on the natural and social sciences. In this framework environmental dematerialization reveals the issue of socio- economic energetic centres - a result of relationship between nature and human rational sensible free will determinism.

  13. Minimizing the Impact of Mining Activities for Sustainable Mined-Out ...

    African Journals Online (AJOL)

    Minimizing the Impact of Mining Activities for Sustainable Mined-Out Area ... sensing and Geographical Information System (GIS) in assessing environmental impact of ... Keywords: Solid mineral, Impact assessment, Mined-out area utilization, ...

  14. Determinants for sustained use of an activity tracker : observational study

    NARCIS (Netherlands)

    Hermsen, Sander; Moons, Jonas; Kerkhof, Peter; Wiekens, Carina; De Groot, Martijn

    2017-01-01

    BACKGROUND: A lack of physical activity is considered to cause 6% of deaths globally. Feedback from wearables such as activity trackers has the potential to encourage daily physical activity. To date, little research is available on the natural development of adherence to activity trackers or on

  15. FOREIGN TRADE TEACHING ACTIVITY: DECIDING BETWEEN COST AND SUSTAINABILITY

    Directory of Open Access Journals (Sweden)

    Cristiano Henrique Antonelli da Veiga

    2015-03-01

    Full Text Available The world debate focused on preserving the environment, such a s that held during the United Nations Conference on Sustainable Development, Rio +20, in conjunction with Brazil’s growing foreign trade requires a study of all these topics in management courses. The central premise of this paper is to investigate the systematization of trade concepts through the use of business games. Two asymmetric scenarios for exporting and importing teams were developed using action research and qualitative data analysis. The longitudinal study was conducted on four separate, sequential classes from the Foreign Trade discipline of two universities from southern Brazilian. The students were able to discuss a variety of foreign trade topics and interact autonomously among themselves using business games that stimulate business negotiations through role playing dynamics, demonstrating that this teaching strategy can be used as a foreign trade teaching support tool. The final proposal was to change the game scenarios to focus on the decision between lowest costs and sustainable manufacturing processes without losing the aspects developed previously. The results showed that students’ decisions are more linked to their prior personal environmental concepts than to competition strategies developed for the company.

  16. Sustainable Architecture in the Context of Regional Activities

    Science.gov (United States)

    Sołkeiewicz-Kos, Nina

    2017-10-01

    The relationship between man and the surrounding cultural environment directs attention in urban and architectural design to the realm of interdisciplinary research. As a result, they should create architectural and urban solutions which provide aesthetic satisfaction. They should also generate social bonds, a sense of identity and maintain the specificity of the local building environment, where tradition and the context of surroundings is the starting point for creating a sustainable living environment. Presented problems focus on the analysis of formal, functional and spatial solutions, in which materials and technology were selected in an optimal way. The continuation of the subject concerns the relationship between the use of the local urban, architectural, material and technological solutions and the quality of the cultural space that meets the principles of sustainable development. Adaptation and transformation of old techniques and traditional materials to create contemporary designs is one of the forms of experimentation encountered in contemporary architecture. Its economic, social and ecological aspects are realised in the form of: satisfying the needs of the local community, renewal and maintenance of modern standards of the surrounding buildings, use of local materials and available space. This means striving to design and transform the space already in use, while reducing the impact on the environment. Analysed buildings and urban spaces are an attempt to answer: whether the strategies applied in the field of architectural, technological and material solutions provide the identification of the place and meet the users’ expectations?

  17. Memory-induced mechanism for self-sustaining activity in networks

    Science.gov (United States)

    Allahverdyan, A. E.; Steeg, G. Ver; Galstyan, A.

    2015-12-01

    We study a mechanism of activity sustaining on networks inspired by a well-known model of neuronal dynamics. Our primary focus is the emergence of self-sustaining collective activity patterns, where no single node can stay active by itself, but the activity provided initially is sustained within the collective of interacting agents. In contrast to existing models of self-sustaining activity that are caused by (long) loops present in the network, here we focus on treelike structures and examine activation mechanisms that are due to temporal memory of the nodes. This approach is motivated by applications in social media, where long network loops are rare or absent. Our results suggest that under a weak behavioral noise, the nodes robustly split into several clusters, with partial synchronization of nodes within each cluster. We also study the randomly weighted version of the models where the nodes are allowed to change their connection strength (this can model attention redistribution) and show that it does facilitate the self-sustained activity.

  18. ANDRA - Annual sustainable development and activity report 2011

    International Nuclear Information System (INIS)

    2012-11-01

    After two texts on the themes of change and dialogue signed by ANDRA's CEO and CBA (Chairman of the Board of Administrators), this report proposes a large overview of the French national radioactive waste management Agency, ANDRA, in the fields of governance (missions, installations, institutional representatives, customers, launching of the Meuse/Haute-Marne inter-district development scheme, 2009 report on the Cigeo project), of human resources (place of women and men, payroll, the Customer Industrial Solutions department, a new approach to customer relations, Cigeo project), of public service missions (site cleaning up, containment of radioactive wastes, radium diagnosis), of industry (Cigeo project, Manche disposal facility, very-low-level waste disposal facility in the Aube district, a crane to move a roof-canopy, low- and intermediate-level waste disposal facility in the Aube district, test of crisis communication, ASN inspections), of the environment (permanent environmental observatory, radiological impact of disposal facilities), of scientific policy (strategic research agenda, relationships with higher education, opinion of experts on ANDRA research), of technological research (new experiments in laboratory, patent in metrology, computer tools, geological knowledge and modelling of the Meuse and Haute-Marne districts, radioactive waste behaviour, issues of intellectual property), of experiments and development, of international commitment and relationships (with South Korea, Eastern Europe, Hungary and Morocco, European directive on radioactive wastes), of sustainable development (local contracts, sponsorship and partnership), of dialogue, transparency and communication, of commitment for future generations, and of future perspectives

  19. Sustainable Regeneration of Nanoparticle Enhanced Activated Carbon in Water

    Science.gov (United States)

    The regeneration and reuse of exhausted granular activated carbon (GAC) is an appropriate method for lowering operational and environmental costs. Advanced oxidation is a promising environmental friendly technique for GAC regeneration. The main objective of this research was to ...

  20. Optimal Hierarchical Modular Topologies for Producing Limited Sustained Activation of Neural Networks

    OpenAIRE

    Kaiser, Marcus; Hilgetag, Claus C.

    2010-01-01

    An essential requirement for the representation of functional patterns in complex neural networks, such as the mammalian cerebral cortex, is the existence of stable regimes of network activation, typically arising from a limited parameter range. In this range of limited sustained activity (LSA), the activity of neural populations in the network persists between the extremes of either quickly dying out or activating the whole network. Hierarchical modular networks were previously found to show...

  1. Social Work with Religious Volunteers: Activating and Sustaining Community Involvement

    Science.gov (United States)

    Garland, Diana R.; Myers, Dennis M.; Wolfer, Terry A.

    2008-01-01

    Social workers in diverse community practice settings recruit and work with volunteers from religious congregations. This article reports findings from two surveys: 7,405 congregants in 35 Protestant congregations, including 2,570 who were actively volunteering, and a follow-up survey of 946 volunteers. It compares characteristics of congregation…

  2. Parallelism Effects and Verb Activation: The Sustained Reactivation Hypothesis

    Science.gov (United States)

    Callahan, Sarah M.; Shapiro, Lewis P.; Love, Tracy

    2010-01-01

    This study investigated the processes underlying parallelism by evaluating the activation of a parallel element (i.e., a verb) throughout "and"-coordinated sentences. Four points were tested: (1) approximately 1,600ms after the verb in the first conjunct (PP1), (2) immediately following the conjunction (PP2), (3) approximately 1,100ms after the…

  3. Sustained Activity in Hierarchical Modular Neural Networks: Self-Organized Criticality and Oscillations

    Science.gov (United States)

    Wang, Sheng-Jun; Hilgetag, Claus C.; Zhou, Changsong

    2010-01-01

    Cerebral cortical brain networks possess a number of conspicuous features of structure and dynamics. First, these networks have an intricate, non-random organization. In particular, they are structured in a hierarchical modular fashion, from large-scale regions of the whole brain, via cortical areas and area subcompartments organized as structural and functional maps to cortical columns, and finally circuits made up of individual neurons. Second, the networks display self-organized sustained activity, which is persistent in the absence of external stimuli. At the systems level, such activity is characterized by complex rhythmical oscillations over a broadband background, while at the cellular level, neuronal discharges have been observed to display avalanches, indicating that cortical networks are at the state of self-organized criticality (SOC). We explored the relationship between hierarchical neural network organization and sustained dynamics using large-scale network modeling. Previously, it was shown that sparse random networks with balanced excitation and inhibition can sustain neural activity without external stimulation. We found that a hierarchical modular architecture can generate sustained activity better than random networks. Moreover, the system can simultaneously support rhythmical oscillations and SOC, which are not present in the respective random networks. The mechanism underlying the sustained activity is that each dense module cannot sustain activity on its own, but displays SOC in the presence of weak perturbations. Therefore, the hierarchical modular networks provide the coupling among subsystems with SOC. These results imply that the hierarchical modular architecture of cortical networks plays an important role in shaping the ongoing spontaneous activity of the brain, potentially allowing the system to take advantage of both the sensitivity of critical states and the predictability and timing of oscillations for efficient information

  4. VELUXlab: a sustainable prototype of active house for innovation

    Directory of Open Access Journals (Sweden)

    Imperadori Marco

    2014-03-01

    Full Text Available Active House is a vision of buildings that create healthier and more comfortable lives for their occupants without impacting negatively on the climate. The concept is based on a responsive behavior of the building, capable to answer instantly to the climate strains changing automatically its configurations and assuring the indoor comfort and energy saving. Active House Alliance is the no-profit organization that is working on this definition and Politecnico di Milano, as member, is developing a solution for the adaptation to the south Europe, where the climate and the weather stress are different. VELUXlab is the first prototype of this vision in Italy. It is the first Italian NZEB in a university campus and, soon, it will be certified also as the first Italian Active House. The wireless sensor network system allows to control in real time the duo envelope (multi-layer dry construction and automation technology performances, strengthening the good results obtained from the virtual dynamic simulations made during the design process.

  5. CHANGES IN QUADRICEPS MUSCLE ACTIVITY DURING SUSTAINED RECREATIONAL ALPINE SKIING

    Directory of Open Access Journals (Sweden)

    Josef Kröll

    2011-03-01

    Full Text Available During a day of skiing thousands of repeated contractions take place. Previous research on prolonged recreational alpine skiing show that physiological changes occur and hence some level of fatigue is inevitable. In the present paper the effect of prolonged skiing on the recruitment and coordination of the muscle activity was investigated. Six subjects performed 24 standardized runs. Muscle activity during the first two (PREskiing and the last two (POSTskiing runs was measured from the vastus lateralis (VL and rectus femoris (RF using EMG and quantified using wavelet and principal component analysis. The frequency content of the EMG signal shifted in seven out of eight cases significantly towards lower frequencies with highest effects observed for RF on outside leg. A significant pronounced outside leg loading occurred during POSTskiing and the timing of muscle activity peaks occurred more towards turn completion. Specific EMG frequency changes were observed at certain time points throughout the time windows and not over the whole double turn. It is suggested that general muscular fatigue, where additional specific muscle fibers have to be recruited due to the reduced power output of other fibers did not occur. The EMG frequency decrease and intensity changes for RF and VL are caused by altered timing (coordination within the turn towards a most likely more uncontrolled skiing technique. Hence, these data provide evidence to suggest recreational skiers alter their skiing technique before a potential change in muscle fiber recruitment occurs

  6. Teaching Sustainability Using an Active Learning Constructivist Approach: Discipline-Specific Case Studies in Higher Education

    Directory of Open Access Journals (Sweden)

    Maria Kalamas Hedden

    2017-07-01

    Full Text Available In this paper we present our rationale for using an active learning constructivist approach to teach sustainability-related topics in a higher education. To push the boundaries of ecological literacy, we also develop a theoretical model for sustainability knowledge co-creation. Drawing on the experiences of faculty at a major Southeastern University in the United States, we present case studies in architecture, engineering, geography, and marketing. Four Sustainability Faculty Fellows describe their discipline-specific case studies, all of which are project-based learning experiences, and include details regarding teaching and assessment. Easily replicated in other educational contexts, these case studies contribute to the advancement of sustainability education.

  7. Changes in Quadriceps Muscle Activity During Sustained Recreational Alpine Skiing

    Science.gov (United States)

    Kröll, Josef; Müller, Erich; Seifert, John G.; Wakeling, James M.

    2011-01-01

    During a day of skiing thousands of repeated contractions take place. Previous research on prolonged recreational alpine skiing show that physiological changes occur and hence some level of fatigue is inevitable. In the present paper the effect of prolonged skiing on the recruitment and coordination of the muscle activity was investigated. Six subjects performed 24 standardized runs. Muscle activity during the first two (PREskiing) and the last two (POSTskiing) runs was measured from the vastus lateralis (VL) and rectus femoris (RF) using EMG and quantified using wavelet and principal component analysis. The frequency content of the EMG signal shifted in seven out of eight cases significantly towards lower frequencies with highest effects observed for RF on outside leg. A significant pronounced outside leg loading occurred during POSTskiing and the timing of muscle activity peaks occurred more towards turn completion. Specific EMG frequency changes were observed at certain time points throughout the time windows and not over the whole double turn. It is suggested that general muscular fatigue, where additional specific muscle fibers have to be recruited due to the reduced power output of other fibers did not occur. The EMG frequency decrease and intensity changes for RF and VL are caused by altered timing (coordination) within the turn towards a most likely more uncontrolled skiing technique. Hence, these data provide evidence to suggest recreational skiers alter their skiing technique before a potential change in muscle fiber recruitment occurs. Key points The frequency content of the EMG signal shifted in seven out of eight cases significantly towards lower frequencies with highest effects observed for RF. General muscular fatigue, where additional specific fibers have to be recruited due to the reduced power output of other fibers, did not occur. A modified skiing style towards a less functional and hence more uncontrolled skiing technique seems to be a key

  8. Sustaining Competitiveness Through product Development Activities Within Malaysian Automotive Suppliers

    Directory of Open Access Journals (Sweden)

    Norizah Mohamad

    2012-01-01

    Full Text Available The local automotive suppliers are facing a number of important challenges such asglobalisation, new requirement in market specifications and the competition brought about by theAsean Free Trade Area (AFTA agreements. In an effort to enhance the competitiveness of themanufacturing sector, the government has implemented the Second Industrial Master Plan, IMP2(1996-2005. The focus of the IMP2 is more on innovation and applications of new technologies, sothat industries can move up the value chain of their activities. Innovative capabilities achieved fromcompanies’ new product development activities have been recognized to be crucial for companies tosustain their competitiveness and organisational success. The importance of product development ismost obvious in the context of the discussion on the competitiveness of the Malaysian automotivesuppliers. The study will focus on the small medium enterprises (SMEs that make up more than 60 %of these automotive suppliers. The study is to determine the extensiveness of the suppliers’ productdevelopment activities by examining the involvement of the suppliers in customer’s productdevelopment activities. Consequently, the impact of this involvement to the competitiveness of thesuppliers is examined. The results were established based from a survey to parts and componentssuppliers of Proton, the Malaysian car national assembler. The study has shown that the SMEs wereinvolved from the early stages of the product development process that is during the design stage. Theproduct development efforts have shown to contribute towards increasing firms’ market share andfirms were also able to gain a better understanding of future product demand. A significant number ofthe suppliers have managed to penetrate the export market. Unfortunately, among the respondents,there is only one system supplier. This indicates that, either the technological capabilities of theSMEs still needed upgrading for the requirement as

  9. Urban farming activity towards sustainable wellbeing of urban dwellers

    Science.gov (United States)

    Othman, N.; Mohamad, M.; Latip, R. A.; Ariffin, M. H.

    2018-02-01

    In Malaysia, urban farming is viewed as a catalyst towards achieving the well-being of urban dwellers and natural environment. Urban farming is a strategy for Malaysia’s food and economic security, and as one of the foci in the agriculture transformation whereby urban dwellers are encouraged to participate in this activity. Previous study proved that urban farming can help to address social problems of food security, urban poverty and high living cost, also provides leisure and recreation among urban dwellers. Thus, this study investigates the best urban farming practices suitable for urban setting, environment and culture of urban dwellers. Data collection was done via questionnaire survey to urban farmers of a selected community garden in Subang Jaya, Selangor. Meanwhile, on-site observations were carried out on gardening activities and the gardens’ physical attributes. The study sample encompasses of 131 urban farmers of 22 community gardens in Subang Jaya. It was found that most of the community gardens practiced crops planting on the ground or soil base planting and dwellers in the lower income group with monthly low household income constitutes the majority (83.2%) of the respondents. Social and health benefits are the highest motivating factors for urban farmers. This study provides unprecedented insights on urban farming practices and motivations in a Malaysian setting.

  10. Promotion as a Tool in Sustaining the Destination Marketing Activities

    Directory of Open Access Journals (Sweden)

    Ivo Mulec

    2010-01-01

    Full Text Available Promoting the tourism destination in the right and best possible way is today one of vital marketing activities of all Destination Management Organizations. Only successful promotion can entice and attract potential travelers to visit the destination. The number of new destinations is increasing every year and some of them are quite similar. Market segmentation is one of the starting points for devising marketing strategy. Only by presenting the destination to the right segment of potential clients in the right way will a destination maximize the effectiveness of its marketing and promotion. Tourism destination marketers will continue to face considerable challenges in the future: they will have to take account of the needs, wants and expectations of more mature and knowledgeable customers, and the corresponding need for more up-to-date and reliable information upon which to base decision-making. In the future only marketing which includes collaborative dimensions will meet its objectives fully.

  11. Optimism predicts sustained vigorous physical activity in postmenopausal women

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    Ana M. Progovac

    2017-12-01

    Full Text Available Optimism and cynical hostility are associated with health behaviors and health outcomes, including morbidity and mortality. This analysis assesses their association with longitudinal vigorous physical activity (PA in postmenopausal women of the Women's Health Initiative (WHI. Subjects include 73,485 women nationwide without history of cancer or cardiovascular disease (CVD, and no missing baseline optimism, cynical hostility, or PA data. The Life Orientation Test-Revised Scale measured optimism. A Cook Medley questionnaire subscale measured cynical hostility. Scale scores were divided into quartiles. Vigorous PA three times or more per week was assessed via self-report at study baseline (1994–1998 and through follow-up year 6. Descriptive analysis mapped lifetime trajectories of vigorous PA (recalled at ages 18, 25, 50; prospectively assessed at baseline, and 3 and 6years later. Hierarchical generalized linear mixed models examined the prospective association between optimism, cynical hostility, and vigorous PA over 6years. Models adjusted for baseline sociodemographic variables, psychosocial characteristics, and health conditions and behaviors. Vigorous PA rates were highest for most optimistic women, but fell for all women by approximately 60% between age 50 and study baseline. In adjusted models from baseline through year 6, most vs. least optimistic women were 15% more likely to exercise vigorously (p<0.001. Cynical hostility was not associated with lower odds of longitudinal vigorous PA after adjustment. Results did not differ by race/ethnicity or socioeconomic status. Higher optimism is associated with maintaining vigorous PA over time in post-menopausal women, and may protect women's health over the lifespan. Keywords: Physical activity, Aging, Optimism, Cynical hostility, women's health

  12. Integrated farm sustainability assessment for the environmental management of rural activities

    International Nuclear Information System (INIS)

    Stachetii Rodrigues, Geraldo; Aparecida Rodrigues, Izilda; Almeida Buschinelli, Claudio Cesar de; Barros, Inacio de

    2010-01-01

    Farmers have been increasingly called upon to respond to an ongoing redefinition in consumers' demands, having as a converging theme the search for sustainable production practices. In order to satisfy this objective, instruments for the environmental management of agricultural activities have been sought out. Environmental impact assessment methods are appropriate tools to address the choice of technologies and management practices to minimize negative effects of agricultural development, while maximizing productive efficiency, sound usage of natural resources, conservation of ecological assets and equitable access to wealth generation means. The 'system for weighted environmental impact assessment of rural activities' (APOIA-NovoRural) presented in this paper is organized to provide integrated farm sustainability assessment according to quantitative environmental standards and defined socio-economic benchmarks. The system integrates sixty-two objective indicators in five sustainability dimensions - (i) Landscape ecology, (ii) Environmental quality (atmosphere, water and soil), (iii) Sociocultural values, (iv) Economic values, and (v) Management and administration. Impact indices are expressed in three integration levels: (i) specific indicators, that offer a diagnostic and managerial tool for farmers and rural administrators, by pointing out particular attributes of the rural activities that may be failing to comply with defined environmental performance objectives; (ii) integrated sustainability dimensions, that show decision-makers the major contributions of the rural activities toward local sustainable development, facilitating the definition of control actions and promotion measures; and (iii) aggregated sustainability index, that can be considered a yardstick for eco-certification purposes. Nine fully documented case studies carried out with the APOIA-NovoRural system, focusing on different scales, diverse rural activities/farming systems, and contrasting

  13. Energy and human activity: Steps toward a sustainable future

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    The potential for improving energy efficiency is enormous, but exploitation of this resource has slowed in recent years. This is regrettable for several reasons. First, not incorporating higher efficiency now often means passing up opportunities that will be more expensive or even impossible to implement in the future. This is especially true for long-lived capital, such as new buildings. Second, reduced research and development into new efficiency options will make it more difficult to accelerate the pace of efficiency improvements in the future. Finally, the flow of more efficient technologies to the non-OECD countries will be hindered by the slowdown in efficiency improvement in the OECD countries. Well-designed policies can help recapture the momentum that has been lost. Some key steps for stimulating more careful use of energy are: rationalize energy pricing and gradually internalize environmental externalities; improve present energy-using capital; implement energy-efficiency standards or agreements for new products and buildings; encourage higher energy efficiency in new products and buildings; promote international cooperation for R ampersand D technology transfer; adjust policies that encourage energy-intensive activities; and promote population restraint worldwide. 25 refs

  14. Sustained activity in hierarchical modular neural networks: self-organized criticality and oscillations

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    Sheng-Jun Wang

    2011-06-01

    Full Text Available Cerebral cortical brain networks possess a number of conspicuous features of structure and dynamics. First, these networks have an intricate, non-random organization. They are structured in a hierarchical modular fashion, from large-scale regions of the whole brain, via cortical areas and area subcompartments organized as structural and functional maps to cortical columns, and finally circuits made up of individual neurons. Second, the networks display self-organized sustained activity, which is persistent in the absence of external stimuli. At the systems level, such activity is characterized by complex rhythmical oscillations over a broadband background, while at the cellular level, neuronal discharges have been observed to display avalanches, indicating that cortical networks are at the state of self-organized criticality. We explored the relationship between hierarchical neural network organization and sustained dynamics using large-scale network modeling. It was shown that sparse random networks with balanced excitation and inhibition can sustain neural activity without external stimulation. We find that a hierarchical modular architecture can generate sustained activity better than random networks. Moreover, the system can simultaneously support rhythmical oscillations and self-organized criticality, which are not present in the respective random networks. The underlying mechanism is that each dense module cannot sustain activity on its own, but displays self-organized criticality in the presence of weak perturbations. The hierarchical modular networks provide the coupling among subsystems with self-organized criticality. These results imply that the hierarchical modular architecture of cortical networks plays an important role in shaping the ongoing spontaneous activity of the brain, potentially allowing the system to take advantage of both the sensitivityof critical state and predictability and timing of oscillations for efficient

  15. Inhibiting the Physiological Stress Effects of a Sustained Attention Task on Shoulder Muscle Activity

    Directory of Open Access Journals (Sweden)

    Fiona Wixted

    2018-01-01

    Full Text Available Objective: The objective of this study was to investigate if a breathing technique could counteract the effects of hyperventilation due to a sustained attention task on shoulder muscle activity. Background: The trend towards higher levels of automation in industry is increasing. Consequently, manufacturing operators often monitor automated process for long periods of their work shift. Prolonged monitoring work requires sustained attention, which is a cognitive process that humans are typically poor at and find stressful. As sustained attention becomes an increasing requirement of manufacturing operators’ job content, the resulting stress experienced could contribute to the onset of many health problems, including work related musculoskeletal disorders (WRMSDs. Methods: The SART attention test was completed by a group of participants before and after a breathing intervention exercise. The effects of the abdominal breathing intervention on breathing rate, upper trapezius muscle activity and end-tidal CO2 were evaluated. Results: The breathing intervention reduced the moderation effect of end-tidal CO2 on upper trapezius muscle activity. Conclusions: Abdominal breathing could be a useful technique in reducing the effects of sustained attention work on muscular activity. Application: This research can be applied to highly-automated manufacturing industries, where prolonged monitoring of work is widespread and could, in its role as a stressor, be a potential contributor to WRMSDs.

  16. Inhibiting the Physiological Stress Effects of a Sustained Attention Task on Shoulder Muscle Activity.

    Science.gov (United States)

    Wixted, Fiona; O'Riordan, Cliona; O'Sullivan, Leonard

    2018-01-11

    The objective of this study was to investigate if a breathing technique could counteract the effects of hyperventilation due to a sustained attention task on shoulder muscle activity. The trend towards higher levels of automation in industry is increasing. Consequently, manufacturing operators often monitor automated process for long periods of their work shift. Prolonged monitoring work requires sustained attention, which is a cognitive process that humans are typically poor at and find stressful. As sustained attention becomes an increasing requirement of manufacturing operators' job content, the resulting stress experienced could contribute to the onset of many health problems, including work related musculoskeletal disorders (WRMSDs). The SART attention test was completed by a group of participants before and after a breathing intervention exercise. The effects of the abdominal breathing intervention on breathing rate, upper trapezius muscle activity and end-tidal CO₂ were evaluated. The breathing intervention reduced the moderation effect of end-tidal CO₂ on upper trapezius muscle activity. Abdominal breathing could be a useful technique in reducing the effects of sustained attention work on muscular activity. This research can be applied to highly-automated manufacturing industries, where prolonged monitoring of work is widespread and could, in its role as a stressor, be a potential contributor to WRMSDs.

  17. Sustainable design training cards as a way to promote active learning

    DEFF Research Database (Denmark)

    Hasling, Karen Marie; Ræbild, Ulla

    2017-01-01

    to understand sustainability in a corporate organisation working with materials and products for the fashion market (authors, 2016). Here the training cards translate these findings to become operationalised in the organisation as a communication tool. The training cards were developed as a methods-focused side...... project that followed a design project conducted by two fashion designers running from August to December 2016. Based on an existing collection of sustainable training cards used in teaching, a draft version of the cards was introduced to the designers in September 2016. In the following months interviews...... and in teaching sustainability in fashion and textiles design education. In the paper we want to discuss, why and how training cards can promote active learning and be used to obtain knowledge on chosen and often complex topics in a simplified manner. This will be based on our experiences with the developed...

  18. Aloe vera in active and passive regions of electronic devices towards a sustainable development

    Science.gov (United States)

    Lim, Zhe Xi; Sreenivasan, Sasidharan; Wong, Yew Hoong; Cheong, Kuan Yew

    2017-07-01

    The increasing awareness towards sustainable development of electronics has driven the search for natural bio-organic materials in place of conventional electronic materials. The concept of using natural bio-organic materials in electronics provides not only an effective solution to address global electronic waste crisis, but also a compelling template for sustainable electronics manufacturing. This paper attempts to provide an overview of using Aloe vera gel as a natural bio-organic material for various electronic applications. Important concepts such as responses of living Aloe vera plant towards electrical stimuli and demonstrations of Aloe vera films as passive and active regions of electronic devices are highlighted in chronological order. The biodegradability and biocompatibility of Aloe vera can bring the world a step closer towards the ultimate goal of sustainable development of electronic devices from "all-natural" materials.

  19. Sustainability Activities In The Mining Sector: Current Status And Challenges Ahead Limestone Mining In Nusakambangan

    Science.gov (United States)

    Ayuningrum, Theresia Vika; Purnaweni, Hartuti

    2018-02-01

    Potential Karst area in Nusakambangan has an important role in maintaining the balance of nature. But with the existence of mining activities, will automatically change the environmental conditions there. In order for the utilization of resources to meet the rules of optimization between the interests of mining and sustainability of the environment so in every mining sector activities required a variety of environmental studies. The purpose of this study is to find out how the analysis of environmental management due to limestone mining activities in Nusakambangan so that it can be known the management of mining areas are optimal, wise based on ecological principles, and sustainability. In qualitative research methods, data analysis using description percentage, with the type of data collected in the form of primary data and secondary data.

  20. THE ACTIVE INTEGRATED CIRCULAR PROCESS – EXPRESSION OF MAXIMUM SYNTHESIS OF SUSTAINABLE DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Done Ioan

    2015-06-01

    Full Text Available "The accelerated pace of economic growth, prompted by the need to ensure reducing disparities between the various countries, has imposed in the last two decades the adoption of sustainable development principles, particularly as a result of the Rio Declaration on Environment and Development (1992 and the UNESCO Declaration in the fall of 1997. In specific literature, in essence, sustainable development is considered "an economic and social process that is characterized by a simultaneous and concerted action at global, regional and local level. Its objective is to provide living conditions both for the present and forth future. Sustainable development “encompasses the economic, ecological, social and political aspects, linked through cultural and spiritual relationships."(Coşea, 2007In Romania, achieving sustainable development is a major, difficult objective, because it must be done in terms of convergence to the demands of the economic, social, cultural and political context of the EU, and in terms of the completion of the transition to a functioning and competitive market economy. In this context, it is imposed the economic competitiveness through reindustrialization and not least, by harnessing the active integrated circular process. Gross value added and profit chain in the structures of active integrated circular process must reflect the interests of the forces involved(employers, employees and the statethereby forming the basis of respect for the correlation between sustainable development, economic growth and increasing national wealth. The elimination or marginalization of certain links in the value chain and profit causes major disruptions or bankruptcy, with direct implications for recognizing and rewarding performance. Essentially, the building of active integrated circular process will determine the maximization of the profit – the foundation of satisfying all economic interests.

  1. Motor unit recruitment and bursts of activity in the surface electromyogram during a sustained contraction.

    Science.gov (United States)

    Riley, Zachary A; Terry, Mary E; Mendez-Villanueva, Alberto; Litsey, Jane C; Enoka, Roger M

    2008-06-01

    Bursts of activity in the surface electromyogram (EMG) during a sustained contraction have been interpreted as corresponding to the transient recruitment of motor units, but this association has never been confirmed. The current study compared the timing of trains of action potentials discharged by single motor units during a sustained contraction with the bursts of activity detected in the surface EMG signal. The 20 motor units from 6 subjects [recruitment threshold, 35.3 +/- 11.3% maximal voluntary contraction (MVC) force] that were detected with fine wire electrodes discharged 2-9 trains of action potentials (7.2 +/- 5.6 s in duration) when recruited during a contraction that was sustained at a force below its recruitment threshold (target force, 25.4 +/- 10.6% MVC force). High-pass filtering the bipolar surface EMG signal improved its correlation with the single motor unit signal. An algorithm applied to the surface EMG was able to detect 75% of the trains of motor unit action potentials. The results indicate that bursts of activity in the surface EMG during a constant-force contraction correspond to the transient recruitment of higher-threshold motor units in healthy individuals, and these results could assist in the diagnosis and design of treatment in individuals who demonstrate deficits in motor unit activation.

  2. Activity-Based Costing Using Multicriteria Drivers: An Accounting Proposal to Boost Companies Toward Sustainability

    Directory of Open Access Journals (Sweden)

    Heitor F. Marinho Neto

    2018-05-01

    Full Text Available Recognizing that natural environment is reaching its maximum limits in providing resources and diluting the waste generated by human production systems, efforts toward more sustainable production systems are mandatory to secure the development of future generations. For this purpose, changing the productivity model adopted by companies that are almost exclusively rooted on circulating money to generate profit, named business as usual, is an important issue. In this sense, an alternative would be establishing the relationship of stocks and flows of energy, material, and information with environmental, economic and social outcomes, thus resulting in new accounting approaches. This work aims to propose an activity-based costing (ABC based on multicriteria drivers including economic, emissions, and emergy (with an “m” values. The proposed ABC costing allocates each one of the multicriteria drivers into a specific part of the sustainability conceptual model, in an attempt to embrace a holistic perspective and allow for a sustainable-based decision, rather than considering purely economic drivers. The goal programming (GP method is considered so as to support a decision based on multicriteria aspects. Results show that the proposed accounting approach known as ABCsustain allows for decisions toward a company's sustainability by acting on both the amount and kind of a company's product that should be managed, as well as on the effective increase of a specific company's activity or process. The proposed ABCsustain could make the insertion of environmental issues into companies strategic planning more effective. It is expected that environmental issues go beyond a simple diagnoses and begin to be considered as action in factum in the companies' decisions toward achieving a more sustainable world system.

  3. Physical activity, sustained sedentary behavior, and pain modulation in women with fibromyalgia.

    Science.gov (United States)

    Ellingson, Laura D; Shields, Morgan R; Stegner, Aaron J; Cook, Dane B

    2012-02-01

    Fibromyalgia (FM) has been conceptualized as a disorder of the central nervous system, characterized by augmented sensory processing and an inability to effectively modulate pain. We previously reported that physical activity is related to brain processing of pain, providing evidence for a potential mechanism of pain management. The purpose of this study was to extend our work by manipulating pain modulation and determining relationships to both physical activity and sustained sedentary behavior. Eleven women with FM completed accelerometer measures of physical activity and underwent functional magnetic resonance imaging of painful heat, administered alone and during distracting cognitive tasks. Results showed that physical activity was significantly (P sedentary time, significant negative relationships were observed in areas involved in both pain modulation and the sensory-discriminative aspects of pain including the DLPFC, thalamus, and superior frontal and pre- and post-central gyri. These results suggest that physical activity and sedentary behaviors are related to central nervous system regulation of pain in FM. Our results support a promising benefit of physical activity and highlight the potentially deleterious effects of sustained sedentary behavior for pain regulation in FM. Studies aimed at increasing physical activity or reducing sedentary behavior and determining the impact of these on pain regulation are warranted. Published by Elsevier Inc.

  4. Individuals with more severe depression fail to sustain nucleus accumbens activity to preferred music over time.

    Science.gov (United States)

    Jenkins, Lisanne M; Skerrett, Kristy A; DelDonno, Sophie R; Patrón, Víctor G; Meyers, Kortni K; Peltier, Scott; Zubieta, Jon-Kar; Langenecker, Scott A; Starkman, Monica N

    2018-05-30

    We investigated the ability of preferred classical music to activate the nucleus accumbens in patients with Major depressive disorder (MDD). Twelve males with MDD and 10 never mentally ill male healthy controls (HC) completed measures of anhedonia and depression severity, and listened to 90-second segments of preferred classical music during fMRI. Compared to HCs, individuals with MDD showed less activation of the left nucleus accumbens (NAcc). Individuals with MDD showed attenuation of the left NAcc response in later compared to earlier parts of the experiment, supporting theories that MDD involves an inability to sustain reward network activation. Counter intuitively, we found that NAcc activity during early music listening was associated with greater depression severity. In whole-brain analyses, anhedonia scores predicted activity in regions within the default mode network, supporting previous findings. Our results support theories that MDD involves an inability to sustain reward network activation. It also highlights that pleasant classical music can engage critical neural reward circuitry in MDD. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Environmental Public Policies: Legalization and Judicial Activism for Sustainable De-velopment

    Directory of Open Access Journals (Sweden)

    Belinda Pereira Cunha

    2016-12-01

    Full Text Available This article analyzes the phenomenon of judicialization of environmental public policies, from the "lens" judicial activism, making sure that we can include the existence of this phenomenon in the treatment of these policies. In our post-modern era we have seen increasingly the role of the judiciary. Thus, we intend to address this issue of judicial activism against such contemporary issues as the environment, seeking to understand how the judiciary behaves in relation to environmental issues, which no longer has time to waive or give up the protection of natural resources and compliance with the principle of sustainable development.

  6. Novel bio-active lipid nanocarriers for the stabilization and sustained release of sitosterol

    International Nuclear Information System (INIS)

    Lacatusu, I; Badea, N; Stan, R; Meghea, A

    2012-01-01

    In this work, new stable and efficiently bio-active lipid nanocarriers (NLCs) with antioxidant properties have been developed for the transport of active ingredients in food. The novel NLCs loaded with β-sitosterol/β-sitosterol and green tea extract (GTE) and prepared by a combination of natural oils (grape seed oil, fish oil and squalene) and biological lipids with food grade surfactants, were physico-chemically examined by DLS, TEM, electrokinetic potential, DSC and HPLC and found to have main diameters less than 200 nm, a spherical morphology, excellent physical stability, an imperfect crystalline lattice and high entrapment efficiency. The novel loaded-NLCs have demonstrated the potential to develop a high blocking action of chain reactions, trapping up to 92% of the free-oxygen radicals, as compared to the native β-sitosterol (AA%=36.5). Another advantage of this study is associated with the quality of bio-active NLCs based on grape seed oil and squalene to manifest a better sitosterol—sustained release behaviour as compared to their related nanoemulsions. By coupling both in vitro results, i.e. the enhanced antioxidant activity and superior release properties, this study emphasizes the sustainability of novel bio-active nanocarriers to gain specific bio-food features for development of functional foods with a high applicability spectrum. (paper)

  7. Self-sustainability of a research reactor facility with neutron activation analysis

    International Nuclear Information System (INIS)

    Chilian, C.; Kennedy, G.

    2010-01-01

    Long-term self-sustainability of a small reactor facility is possible because there is a large demand for non-destructive chemical analysis of bulk materials that can only be achieved with neutron activation analysis (NAA). The Ecole Polytechnique Montreal SLOWPOKE Reactor Facility has achieved self-sustainability for over twenty years, benefiting from the extreme reliability, ease of use and stable neutron flux of the SLOWPOKE reactor. The industrial clientele developed slowly over the years, mainly because of research users of the facility. A reliable NAA service with flexibility, high accuracy and fast turn-around time was achieved by developing an efficient NAA system, using a combination of the relative and k0 standardisation methods. The techniques were optimized to meet the specific needs of the client, such as low detection limit or high accuracy at high concentration. New marketing strategies are presented, which aim at a more rapid expansion. (author)

  8. Consumer Culture, Sustainability and Business Practice: How Companies can Promote the Symbolic Value of Sustainability in Consumption Activities?

    Directory of Open Access Journals (Sweden)

    Verônica Macário de Oliveira

    2016-05-01

    Full Text Available Discussions on sustainability began recently to focus on the consumption patterns of contemporary society as a major causative factors of social and environmental problems. Thus, the aim of this paper is to discuss some opportunities that companies have to influence these changes consumption patterns towards sustainability, taking as a basis the view discussed in studies of Rindova and Ravasi (2008 who consider firms as producers of culture. To this end, we performed a theoretical essay. The results show that companies can influence the formation of specific cultures with the symbolic construction of sustainable practices, contributing to the formation of a culture of sustainable consumption. This occurs from innovation in their ways of working, considering that evoke meanings that products appear to be influenced by strategic choices of producers, such as the concepts and philosophies of design (Ravasi; Rindova, 2008, which includes the development new technologies and practices (Michaelis, 2003 based on the principles of eco-efficiency (Barber, 2008; Clark, 2008, as well as changes in values and discourses that shape the cultures of business, government, media and civil society (Michaelis, 2003, also aligned with the ethical principles and shared environmental responsibility (Tukkeret al, 2008.

  9. Sustainability of Physical Activity Promoting Environments and Influences on Sustainability Following a Structural Intervention in Residential Children's Homes

    Science.gov (United States)

    Dominick, Gregory M.; Tudose, Alina; Pohlig, Ryan T.; Saunders, Ruth P.

    2016-01-01

    Research examining sustainability of health promotion programs within organizational settings is limited. The Environmental Interventions in Residential Children's Homes (ENRICH) was a structural intervention that trained Wellness Teams (WTs) within residential children's homes (RCH) to target environmental changes that promote physical activity…

  10. Assessment of Farming Systems for Sustainability of Farming Activities in the Mazandaran Province

    Directory of Open Access Journals (Sweden)

    H. Moumenihelali

    2016-03-01

    Full Text Available Introduction: One of the fundamental issues in the agricultural sector in Iran is the absence of optimal water and soil resources utilization and lack of new agricultural science and technology adoption through major prevailing transformations in agricultural land exploitation system. The studies conducted in the history of agricultural development in Iran cast light on the fact that the farming system’s role in the agricultural development in Iran is of great importance. And water and soil resources utilization has been one of the fundamental issues of agriculture which has enjoyed major consideration after the implementation of land restructuring. The agriculture farming systems are referred to as the focus of all activities related to sustainable agricultural development in Iran and it is believed that the shift and transition from traditional agriculture to modern and profitable agriculture through appropriate, improved and newly developed agricultural establishments are the major activities which can increase productivity and improve the overall performance of the agricultural sector and thus contribute to sustainable development more than any other factor. Hence, such significance will be more evident when the small and scattered farmlands in many cases have imposed some limitations in the application of agricultural techniques and machinery, equipping and developing the infrastructure and efficient use of resources with appropriate performance forcing agricultural policymakersto be always looking for ways to deal with it. Therefore, identifying the relative advantage of any farming system specified for each area and region in the country seems important. Accordingly, the Mazandaran province is regarded as one of the production hubs in producing crops such as rice, wheat and canola in the country playing a major role in supplying food. With a detailed analysis of research literature, the economic, ecological, social, technical and policy

  11. Alkali-Activated Mortars for Sustainable Building Solutions: Effect of Binder Composition on Technical Performance

    Directory of Open Access Journals (Sweden)

    Agnese Attanasio

    2018-02-01

    Full Text Available There is a growing interest in the construction sector in the use of sustainable binders as an alternative to ordinary Portland cement, the production of which is highly impacting on the environment, due to high carbon dioxide emissions and energy consumption. Alkali-activated binders, especially those resulting from low-cost industrial by-products, such as coal fly ash or metallurgical slag, represent a sustainable option for cement replacement, though their use is more challenging, due to some technological issues related to workability or curing conditions. This paper presents sustainable alkali-activated mortars cured in room conditions and based on metakaolin, fly ash, and furnace slag (both by-products resulting from local sources and relevant blends, aiming at their real scale application in the building sector. The effect of binder composition—gradually adjusted taking into consideration technical and environmental aspects (use of industrial by-products in place of natural materials in the view of resources saving—on the performance (workability, compressive strength of different mortar formulations, is discussed in detail. Some guidelines for the design of cement-free binders are given, taking into consideration the effect of each investigated alumino-silicate component. The technical feasibility to produce the mortars with standard procedures and equipment, the curing in room conditions, the promising results achieved in terms of workability and mechanical performance (from 20.0 MPa up to 52.0 MPa, confirm the potential of such materials for practical applications (masonry mortars of class M20 and Md. The cement-free binders resulting from this study can be used as reference for the development of mortars and concrete formulations for sustainable building materials production.

  12. Inhibition of proteases activity in intestine needs a sustainable acidic environment rather than a transient.

    Science.gov (United States)

    Xing, Chang; Xing, Jin-Feng; Ge, Zhi-Qiang

    2017-10-01

    α-Chymotrypsin (α-CT) and trypsin are important components of the enzymatic barrier. They could degrade the therapeutic proteins and peptides, inhibit their activity consequently, and thereby reduce their oral bioavailability. Acidic agents, as one type of indirect protease inhibitors, have shown proof of concept in clinical trials. We report here the inactivated proteases due to acid influence can be reactivated immediately by environmental pH recovery regardless of how long the inactivation last. To keep the inactivation time of proteases for 4-5 h, we designed and prepared a sustained-release tablet containing citric acid (CA) which can effectively reduce the pH below 5.0 and maintain it for 5 h in the dissolution-reaction medium. The activity of α-CT and trypsin was quantified by analyzing the residual amount of their respective substrates BTEE and TAME. More than 80% of the substrates were survived in 5.0 h of incubation, whereas the common tablet inhibited the proteases activity for only two hours in the same experimental medium. It indicates that the sustained-release tablet loaded with CA can efficiently inhibit the α-CT and trypsin activity longer than the common tablet. The results will be beneficial for designing and formulating the peroral administration of peptide and protein drugs.

  13. A comparison between effectiveness of three types of music on memory activity and sustained attention in schizophrenic patients

    OpenAIRE

    Narges bahmany; Karamatollah Zandi ghashghaee; Sadrollah Khosravi

    2014-01-01

    Background: schizophrenia is a psychiatric disorder in which a lot of cognitive functions including memory, attention, motor skills, executive functions and intelligence are compromised. Numerous empirical studies showed that schizophrenic patients have problem in sustain retention and memory activity. The objective of this study was a comparison between effectiveness of three types of music on memory activity and sustain retention in schizophrenic patients. Material and Methods: A total of 6...

  14. Bistability Analysis of Excitatory-Inhibitory Neural Networks in Limited-Sustained-Activity Regime

    International Nuclear Information System (INIS)

    Ni Yun; Wu Liang; Wu Dan; Zhu Shiqun

    2011-01-01

    Bistable behavior of neuronal complex networks is investigated in the limited-sustained-activity regime when the network is composed of excitatory and inhibitory neurons. The standard stability analysis is performed on the two metastable states separately. Both theoretical analysis and numerical simulations show consistently that the difference between time scales of excitatory and inhibitory populations can influence the dynamical behaviors of the neuronal networks dramatically, leading to the transition from bistable behaviors with memory effects to the collapse of bistable behaviors. These results may suggest one possible neuronal information processing by only tuning time scales. (interdisciplinary physics and related areas of science and technology)

  15. Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity.

    Science.gov (United States)

    Shen, Duanwen; Bai, Mingfeng; Tang, Rui; Xu, Baogang; Ju, Xiaoming; Pestell, Richard G; Achilefu, Samuel

    2013-01-01

    Using a newly developed near-infrared (NIR) dye that fluoresces at two different wavelengths (dichromic fluorescence, DCF), we discovered a new fluorescent substrate for Akt, also known as protein kinase B, and a method to quantitatively report this enzyme's activity in real time. Upon insulin activation of cellular Akt, the enzyme multi-phosphorylated a single serine residue of a diserine DCF substrate in a time-dependent manner, culminating in monophospho- to triphospho-serine products. The NIR DCF probe was highly selective for the Akt1 isoform, which was demonstrated using Akt1 knockout cells derived from MMTV-ErbB2 transgenic mice. The DCF mechanism provides unparalleled potential to assess the stimulation, sustainability, and reversibility of Akt activation longitudinally. Importantly, NIR fluorescence provides a pathway to translate findings from cells to living organisms, a condition that could eventually facilitate the use of these probes in humans.

  16. Status of calcium regulating hormonal systems in delayed period in persons exposed to occupational exposure of low doses of ionizing radiations

    International Nuclear Information System (INIS)

    Dospolova, Zh.G.; Abylaev, Zh.A.

    1997-01-01

    Purpose of study is consideration of endocrine system participation in development of calcium exchange disorders in persons exposed to action of low dose radiation . By radio- immune method in blood serum of 150 liquidators of Chernobyl accident consequences the concentration the following hormones were determined: parathormone, T 3 , T 4 , TSH, cortisol, ACTH, testosteron, insulin. Content of these hormones have been studied in according to following radiation factors: value of absorbed doses of external irradiation, degree of radioactive contamination of zone and exposition duration. It was determined, that basically dishormone disorders development have been concerned with parathormone, cortisol, hormones of thyroid axis, and in some cases to ACTH and insulin. Liquidators' frequencies of normal and changed concentration of calcium regulating hormones are sited in tabular form. It was established, that examined persons in result hormone disorders have of decrease functions of pituitary glands (76.78 %), pancreas (55 %), thyroid gland (24.31 %) and sex glands (19.23 %) and simultaneously cases of increase functions of parathyroid gland (58.2 %), adrenal glands (52.32 %) and adeno-pituitary glands (17.39). It is concluded, that inter hormonal correlation disorders are accompanying with morphologic and functional futures of secretory activity changes

  17. Intermittent but not sustained hypoxia activates orexin-containing neurons in mice.

    Science.gov (United States)

    Yamaguchi, Keiji; Futatsuki, Takahiro; Ushikai, Jumpei; Kuroki, Chiharu; Minami, Toshiaki; Kakihana, Yasuyuki; Kuwaki, Tomoyuki

    2015-01-15

    Hypothalamic orexin-containing neurons are activated by CO2 and contribute to hypercapnic ventilatory activation. However, their role in oxygen-related regulation of breathing is not well defined. In this study, we examined whether an experimental model mimicking apnea-induced repetitive hypoxemia (intermittent hypoxia [IH]) activates orexin-containing neurons. Mice were exposed to IH (5×5min at 10% O2), intermittent hyperoxia (IO; 5×5min at 50% O2), sustained hypoxia (SH; 25min at 10% O2), or sham stimulation. Their brains were examined using double immunohistochemical staining for orexin and c-Fos. The results indicated that IH (25.8±3.0%), but not SH (9.0±1.5%) activated orexin-containing neurons when compared to IO (5.5±0.6%) and sham stimulation (5.9±1.4%). These results correlate with those of our previous work showing that IH-induced respiratory long-term facilitation is dependent on orexin-containing neurons. Taken together, orexin contributes to repetitive hypoxia-induced respiratory activation and the hypoxic activation of orexin-containing neurons is pattern dependent. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. Sustained mitogen-activated protein kinase activation reprograms defense metabolism and phosphoprotein profile in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Ines eLassowskat

    2014-10-01

    Full Text Available Mitogen-activated protein kinases (MAPKs target a variety of protein substrates to regulate cellular signaling processes in eukaryotes. In plants, the number of identified MAPK substrates that control plant defense responses is still limited. Here, we generated transgenic Arabidopsis thaliana plants with an inducible system to simulate in vivo activation of two stress-activated MAPKs, MPK3 and MPK6. Metabolome analysis revealed that this artificial MPK3/6 activation (without any exposure to pathogens or other stresses is sufficient to drive the production of major defense-related metabolites, including various camalexin, indole glucosinolate and agmatine derivatives. An accompanying (phosphoproteome analysis led to detection of hundreds of potential phosphoproteins downstream of MPK3/6 activation. Besides known MAPK substrates, many candidates on this list possess typical MAPK-targeted phosphosites and in many cases, the corresponding phosphopeptides were detected by mass spectrometry. Notably, several of these putative phosphoproteins have been reported to be associated with the biosynthesis of antimicrobial defense substances (e.g. WRKY transcription factors and proteins encoded by the genes from the PEN pathway required for penetration resistance to filamentous pathogens. Thus, this work provides an inventory of candidate phosphoproteins, including putative direct MAPK substrates, for future analysis of MAPK-mediated defense control. (Proteomics data are available with the identifier PXD001252 via ProteomeXchange, http://proteomecentral.proteomexchange.org.

  19. Sustainability via Active Garden Education (SAGE): results from two feasibility pilot studies.

    Science.gov (United States)

    Lee, Rebecca E; Parker, Nathan H; Soltero, Erica G; Ledoux, Tracey A; Mama, Scherezade K; McNeill, Lorna

    2017-03-10

    Low physical activity (PA) and fruit and vegetable (F&V) consumption in early childhood are continued public health challenges. This manuscript describes outcomes from two pilot studies for Sustainability via Active Garden Education (SAGE), a program designed to increase PA and F&V consumption among 3 to 5 year old children. SAGE was developed using community-based participatory research (CBPR) and delivered to children (N = 89) in early care and education centers (ECEC, N = 6) in two US cities. Children participated in 12 one-hour sessions that included songs, games, and interactive learning activities involving garden maintenance and taste tests. We evaluated reach, efficacy, adoption, implementation, and potential for maintenance of SAGE following the RE-AIM framework. Reach was evaluated by comparing demographic characteristics among SAGE participants and residents of target geographic areas. Efficacy was evaluated with accelerometer-measured PA, F&V consumption, and eating in the absence of hunger among children, parenting practices regarding PA, and home availability of F&V. Adoption was evaluated by the number of ECEC that participated relative to the number of ECEC that were recruited. Implementation was evaluated by completion rates of planned SAGE lessons and activities, and potential for maintenance was evaluated with a parent satisfaction survey. SAGE reached ECEC in neighborhoods representing a wide range of socioeconomic status, with participants' sociodemographic characteristics representing those of the intervention areas. Children significantly increased PA during SAGE lessons compared to usual lessons, but they also consumed more calories in the absence of hunger in post- vs. pre-intervention tests (both p nutrition guidelines for young children. SAGE successfully translated national PA guidelines to practice for young children but was less successful with nutrition guidelines. High adoption and implementation and favorable parent

  20. Iron-Catalyzed C-O Bond Activation: Opportunity for Sustainable Catalysis.

    Science.gov (United States)

    Bisz, Elwira; Szostak, Michal

    2017-10-23

    Oxygen-based electrophiles have emerged as some of the most valuable cross-coupling partners in organic synthesis due to several major strategic and environmental benefits, such as abundance and potential to avoid toxic halide waste. In this context, iron-catalyzed C-O activation/cross-coupling holds particular promise to achieve sustainable catalytic protocols due to its natural abundance, inherent low toxicity, and excellent economic and ecological profile. Recently, tremendous progress has been achieved in the development of new methods for functional-group-tolerant iron-catalyzed cross-coupling reactions by selective C-O cleavage. These methods establish highly attractive alternatives to traditional cross-coupling reactions by using halides as electrophilic partners. In particular, new easily accessible oxygen-based electrophiles have emerged as substrates in iron-catalyzed cross-coupling reactions, which significantly broaden the scope of this catalysis platform. New mechanistic manifolds involving iron catalysis have been established; thus opening up vistas for the development of a wide range of unprecedented reactions. The synthetic potential of this sustainable mode of reactivity has been highlighted by the development of new strategies in the construction of complex motifs, including in target synthesis. The most recent advances in sustainable iron-catalyzed cross-coupling of C-O-based electrophiles are reviewed, with a focus on both mechanistic aspects and synthetic utility. It should be noted that this catalytic manifold provides access to motifs that are often not easily available by other methods, such as the assembly of stereodefined dienes or C(sp 2 )-C(sp 3 ) cross-couplings, thus emphasizing the synthetic importance of this mode of reactivity. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. ANDRA - National Radioactive Waste Management Agency. Activity report and sustainable development 2013. Financial report 2013

    International Nuclear Information System (INIS)

    2014-01-01

    Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and Sustainable Development Report, with the financial report, of the Andra for the year 2013

  2. Sustained antimicrobial activity and reduced toxicity of oxidative biocides through biodegradable microparticles.

    Science.gov (United States)

    Sofokleous, Panagiotis; Ali, Shanom; Wilson, Peter; Buanz, Asma; Gaisford, Simon; Mistry, Dharmit; Fellows, Adrian; Day, Richard M

    2017-12-01

    The spread of antibiotic-resistant pathogens requires new treatments. Small molecule precursor compounds that produce oxidative biocides with well-established antimicrobial properties could provide a range of new therapeutic products to combat resistant infections. The aim of this study was to investigate a novel biomaterials-based approach for the manufacture, targeted delivery and controlled release of a peroxygen donor (sodium percarbonate) combined with an acetyl donor (tetraacetylethylenediamine) to deliver local antimicrobial activity via a dynamic equilibrium mixture of hydrogen peroxide and peracetic acid. Entrapment of the pre-cursor compounds into hierarchically structured degradable microparticles was achieved using an innovative dry manufacturing process involving thermally induced phase separation (TIPS) that circumvented compound decomposition associated with conventional microparticle manufacture. The microparticles provided controlled release of hydrogen peroxide and peracetic acid that led to rapid and sustained killing of multiple drug-resistant organisms (methicillin-resistant Staphylococcus aureus and carbapenem-resistant Escherichia coli) without associated cytotoxicity in vitro nor intracutaneous reactivity in vivo. The results from this study demonstrate for the first time that microparticles loaded with acetyl and peroxygen donors retain their antimicrobial activity whilst eliciting no host toxicity. In doing so, it overcomes the detrimental effects that have prevented oxidative biocides from being used as alternatives to conventional antibiotics. The manuscript explores a novel approach to utilize the antimicrobial activity of oxidative species for sustained killing of multiple drug-resistant organisms without causing collateral tissue damage. The results demonstrate, for the first time, the ability to load pre-cursor compounds into porous polymeric structures that results in their release and conversion into oxidative species in a

  3. The Influence of Board of Directors, Independent Board of Commissioners, Leverage, and Corporate Activities To Disclosure of Sustainability Report.

    Directory of Open Access Journals (Sweden)

    Eria Nissa Awalia

    2015-07-01

    Full Text Available This research was intended to examine the influences of board of directors, board of independent commissioner, leverage, and activity of company toward sustainability report disclosure. Sustainability Report Disclosure is the dependent variable sinthis research were measured by GRIG 3.1 Content Index and Checklists. For the independent variables in this research, using board of directors were measured by sum of directors meetings, board of in dependent commissioner were measured by proportion of independent commissioner, leverage were measured by debt to equity, activity of company were measured by total asset turnover. This research uses secondary data which is financial statement. and sustainability report from Indonesian Stock Exchange Listed Companies in 2010-2012. While the sampling method used was purposive sampling method which is overall 39 observations. This research uses multiple regression method to test the hypothesis with SPSS computer program. From the analysis performed in this research, it can be concluded that board of directors, and leverage have no significant influence to sustainability report disclosure. The other hand activity of company has positive influence and significant to sustainability report disclosure. And Board of independent commissioner has negative influence and significant to sustainability reporting disclosure.

  4. Towards transdisciplinarity in Arctic sustainability knowledge co-production: Socially-Oriented Observations as a participatory integrated activity

    Science.gov (United States)

    Vlasova, Tatiana; Volkov, Sergey

    2016-09-01

    The paper is an attempt to tie together main biogeophysical and social science projects under the auspice of interdisciplinary sustainability science development. Special attention is put to the necessity of the transdisciplinary knowledge co-production based on activities and problem-solutions approaches. It puts attention to the role of monitoring activities in sustainability interdisciplinary science and transdisciplinary knowledge evolution in the Arctic. Socially focused monitoring named Socially-Oriented Observations creating a transdisciplinary space is viewed as one of sources of learning and transformations towards sustainability making possible to shape rapid changes happening in the Arctic based on sustainability knowledge co-production. Continuous Socially-Oriented Observations integrating scientific, education and monitoring methods enables to define adaptation and transformation pathways in the Arctic - the most rapidly changing region of our planet. Socially-Oriented Observations are based on the existing and developing interdisciplinary scientific approaches emerged within natural science and social science projects, sustainable development and resilience concepts putting principle attention to building sustainable and resilient socio-ecological systems. It is argued that the Arctic sustainability science is a valuable component of the whole and broader system of the Arctic Sustainability knowledge co-produced with the help of transdisciplinary approaches integrating science, local/traditional knowledge, entrepreneurship, education, decision-making. Socially-Oriented Observations are designed to be a transdisciplinary interactive continuous participatory process empowering deliberate choices of people that can shape the changes and enable transformation towards sustainability. Approaches of Socially-Oriented Observations and methods of implementation that have been developed since the IPY 2007/2008 and being practiced in different regions of the

  5. Transient and sustained cortical activity elicited by connected speech of varying intelligibility

    Directory of Open Access Journals (Sweden)

    Tiitinen Hannu

    2012-12-01

    Full Text Available Abstract Background The robustness of speech perception in the face of acoustic variation is founded on the ability of the auditory system to integrate the acoustic features of speech and to segregate them from background noise. This auditory scene analysis process is facilitated by top-down mechanisms, such as recognition memory for speech content. However, the cortical processes underlying these facilitatory mechanisms remain unclear. The present magnetoencephalography (MEG study examined how the activity of auditory cortical areas is modulated by acoustic degradation and intelligibility of connected speech. The experimental design allowed for the comparison of cortical activity patterns elicited by acoustically identical stimuli which were perceived as either intelligible or unintelligible. Results In the experiment, a set of sentences was presented to the subject in distorted, undistorted, and again in distorted form. The intervening exposure to undistorted versions of sentences rendered the initially unintelligible, distorted sentences intelligible, as evidenced by an increase from 30% to 80% in the proportion of sentences reported as intelligible. These perceptual changes were reflected in the activity of the auditory cortex, with the auditory N1m response (~100 ms being more prominent for the distorted stimuli than for the intact ones. In the time range of auditory P2m response (>200 ms, auditory cortex as well as regions anterior and posterior to this area generated a stronger response to sentences which were intelligible than unintelligible. During the sustained field (>300 ms, stronger activity was elicited by degraded stimuli in auditory cortex and by intelligible sentences in areas posterior to auditory cortex. Conclusions The current findings suggest that the auditory system comprises bottom-up and top-down processes which are reflected in transient and sustained brain activity. It appears that analysis of acoustic features occurs

  6. Gascoyne Growers Market: a sustainable health promotion activity developed in partnership with the community.

    Science.gov (United States)

    Payet, Jennifer; Gilles, Marisa; Howat, Peter

    2005-10-01

    To explore the social, health and economic impact of a farmers' market on a small rural community in the north of Western Australia. Qualitative and quantitative research using a random structured intercept survey, and focus group interviews around four domains of social capital: economic impact, governance and capacity building, healthy public places and social and civic participation. The Gascoyne Growers Markets in Carnarvon. One hundred consumers and 28 market stallholders. Consumers demonstrated community pride and an increase in fruit and vegetable consumption since they commenced shopping at the markets. The stallholders appear to have gained economically, professionally and socially from the market experience. The Gascoyne Growers Markets demonstrate a sustainable health promotion activity developed in partnership with the community. It has contributed to the local economy, providing local quality fruit and vegetables directly to the community while also increasing social capital and creating a healthy public space.

  7. The Stability, Sustained Release and Cellular Antioxidant Activity of Curcumin Nanoliposomes

    Directory of Open Access Journals (Sweden)

    Xing Chen

    2015-08-01

    Full Text Available Curcumin is a multifunctional and natural agent considered to be pharmacologically safe. However, its application in the food and medical industry is greatly limited by its poor water solubility, physicochemical instability and inadequate bioavailability. Nanoliposome encapsulation could significantly enhance the solubility and stability of curcumin. Curcumin nanoliposomes exhibited good physicochemical properties (entrapment efficiency = 57.1, particle size = 68.1 nm, polydispersity index = 0.246, and zeta potential = −3.16 mV. Compared with free curcumin, curcumin nanoliposomes exhibited good stability against alkaline pH and metal ions as well as good storage stability at 4 °C. Curcumin nanoliposomes also showed good sustained release properties. Compared with free curcumin, curcumin nanoliposomes presented an equal cellular antioxidant activity, which is mainly attributed to its lower cellular uptake as detected by fluorescence microscopy and flow cytometry. This study provide theoretical and practical guides for the further application of curcumin nanoliposomes.

  8. RTE - Activity and sustainable development report 2012 - In line with the future

    International Nuclear Information System (INIS)

    2013-01-01

    RTE, an independent subsidiary of EDF, is the French electricity transmission system operator. It is a public service company responsible for operating, maintaining and developing the high and extra high voltage network. It guarantees the reliability and proper operation of the power network. RTE transports electricity between electricity suppliers (French and European) and consumers, whether they are electricity distributors or industrial consumers directly connected to the transmission system. The mission of RTE is to balance the electricity supply and demand in real time. This publication gathers in a single document the 2012 Activity and Sustainable development report of RTE, the Management report with the consolidated financial statements, and the Report from the chairman of the supervisory board

  9. Subsidence monitoring network: an Italian example aimed at a sustainable hydrocarbon E&P activity

    Directory of Open Access Journals (Sweden)

    M. C. Dacome

    2015-11-01

    Full Text Available According to the Italian law in order to start-up any new hydrocarbon exploitation activity, an Environmental Impact Assessment study has to be presented, including a monitoring plan, addressed to foresee, measure and analyze in real time any possible impact of the project on the coastal areas and on those ones in the close inland located. The occurrence of subsidence, that could partly be related to hydrocarbon production, both on-shore and off-shore, can generate great concern in those areas where its occurrence may have impacts on the local environment. ENI, following the international scientific community recommendations on the matter, since the beginning of 90's years, implemented a cutting-edge monitoring network, with the aim to prevent, mitigate and control geodynamics phenomena generated in the activity areas, with a particular attention to conservation and protection of environmental and territorial equilibrium, taking care of what is known as "sustainable development". The current ENI implemented monitoring surveys can be divided as: – Shallow monitoring: spirit levelling surveys, continuous GPS surveys in permanent stations, SAR surveys, assestimeter subsurface compaction monitoring, ground water level monitoring, LiDAR surveys, bathymetrical surveys. – Deep monitoring: reservoir deep compaction trough radioactive markers, reservoir static (bottom hole pressure monitoring. All the information, gathered through the monitoring network, allow: 1. to verify if the produced subsidence is evolving accordingly with the simulated forecast. 2. to provide data to revise and adjust the prediction compaction models 3. to put in place the remedial actions if the impact exceeds the threshold magnitude originally agreed among the involved parties. ENI monitoring plan to measure and monitor the subsidence process, during field production and also after the field closure, is therefore intended to support a sustainable field development and an

  10. Subsidence monitoring network: an Italian example aimed at a sustainable hydrocarbon E&P activity

    Science.gov (United States)

    Dacome, M. C.; Miandro, R.; Vettorel, M.; Roncari, G.

    2015-11-01

    According to the Italian law in order to start-up any new hydrocarbon exploitation activity, an Environmental Impact Assessment study has to be presented, including a monitoring plan, addressed to foresee, measure and analyze in real time any possible impact of the project on the coastal areas and on those ones in the close inland located. The occurrence of subsidence, that could partly be related to hydrocarbon production, both on-shore and off-shore, can generate great concern in those areas where its occurrence may have impacts on the local environment. ENI, following the international scientific community recommendations on the matter, since the beginning of 90's years, implemented a cutting-edge monitoring network, with the aim to prevent, mitigate and control geodynamics phenomena generated in the activity areas, with a particular attention to conservation and protection of environmental and territorial equilibrium, taking care of what is known as "sustainable development". The current ENI implemented monitoring surveys can be divided as: - Shallow monitoring: spirit levelling surveys, continuous GPS surveys in permanent stations, SAR surveys, assestimeter subsurface compaction monitoring, ground water level monitoring, LiDAR surveys, bathymetrical surveys. - Deep monitoring: reservoir deep compaction trough radioactive markers, reservoir static (bottom hole) pressure monitoring. All the information, gathered through the monitoring network, allow: 1. to verify if the produced subsidence is evolving accordingly with the simulated forecast. 2. to provide data to revise and adjust the prediction compaction models 3. to put in place the remedial actions if the impact exceeds the threshold magnitude originally agreed among the involved parties. ENI monitoring plan to measure and monitor the subsidence process, during field production and also after the field closure, is therefore intended to support a sustainable field development and an acceptable exploitation

  11. Sustainability in Transport Planning

    DEFF Research Database (Denmark)

    Gudmundsson, Henrik; Greve, Carsten

    Contribution to session J: Joint University Sustainability Initiatives. This session will provide an inspiring overview of interdisciplinary research and teaching activities on sustainability bridging DTU, KU, and CBS, and introduce the joint collaboration Copenhagen Sustainability Initiative (COSI...

  12. RTE - Activity and sustainable development report 2014. Management report consolidated financial statements 2014

    International Nuclear Information System (INIS)

    2015-01-01

    After an interview of RTE's CEO, an overview of governance issues within the company, and a presentation of its business model, the activity report addresses the various aspects of RTE activities during 2014: grid expertise, a fair and balanced service, performance at the right price, cooperation between all players, a long term commitment, and perspectives. It also focuses on the corporate aspects: collective intelligence, workforce involvement, safety culture. The management report contains financial and legal information (significant events of 2014, economic environment, business and results, financing, financial structure, outlook for 2015, risk analysis), company information (employment, work organisation, labour relations, health and safety, training, diversity and equal opportunities, compliance with International Labour Organisation conventions), environmental information (general environmental policy, pollution and waste management, sustainable use of resources, climate change, protection and development of biodiversity), and societal information (local, economic and social impact of RTE's business, relations with people and organisations concerned by RTE's business, out-sourcing and suppliers, fair practices, other action to promote human rights). The third report presents the supervisory board (members and missions, operation, committees), the Executive Board (members and remuneration principles), the operation of general assemblies. It describes the internal control of RTE (organisation, actors), presents the policy of risk management and control, activities of audit and control within RTE. It finally presents external controls made by different public bodies

  13. The impact of green logistics-based activities on the sustainable monetary expansion indicators of Oman

    International Nuclear Information System (INIS)

    Alshubiri, Faris

    2017-01-01

    The purpose of this study is to examine green logistic activities by three axes (financial economic, social and environment activities) and how these activities affect on sustainable monetary expansion indicators as an evidence of Sultanate of Oman. Design/methodology/approach: This study began by definition elements of logistic green and how evolution of this concept in recent years. This concept analyzed after survey of previous studies on green logistic. The independent variables of green logistic are includes of three components of financial economic , social and environment and applies these components to clarify the impact on expansionary monetary policy indicators ( broad , narrow and reserve money ) as a important signals in determining a country's economy. This study used data published in statistical annual report of central bank of Oman as representative of country economic of sultanate of Oman from the period 2008 to 2015. Findings: The results found two variables of government support to electricity sector (GSE) and subsidy on soft loans to private sector and housing (SSLPH) based on environment activities are statistical significant 1% and 5%. Only one variable of transport and communication (TC) in financial economic activates is statistical significant at 1% and 5% , but all variables community, social and personal (CSP) , cultural and religious affairs (CRA) and social security and welfare (SSW) in social activities are statistical significant at 1% 5% and 10% , finally , also the multiple regression test run of all variables of green logistics activities and each monetary expansion indicators and found there are a statistical significant at 1% and 5%, .The study recommends that should be attention with financial economic activities as a quantitative standard contributes to build the green logistic by diagnosed the priorities and existing economic and financial system that contributes of sustainable development system in the country

  14. The impact of green logistics-based activities on the sustainable monetary expansion indicators of Oman

    Energy Technology Data Exchange (ETDEWEB)

    Alshubiri, Faris

    2017-07-01

    The purpose of this study is to examine green logistic activities by three axes (financial economic, social and environment activities) and how these activities affect on sustainable monetary expansion indicators as an evidence of Sultanate of Oman. Design/methodology/approach: This study began by definition elements of logistic green and how evolution of this concept in recent years. This concept analyzed after survey of previous studies on green logistic. The independent variables of green logistic are includes of three components of financial economic , social and environment and applies these components to clarify the impact on expansionary monetary policy indicators ( broad , narrow and reserve money ) as a important signals in determining a country's economy. This study used data published in statistical annual report of central bank of Oman as representative of country economic of sultanate of Oman from the period 2008 to 2015. Findings: The results found two variables of government support to electricity sector (GSE) and subsidy on soft loans to private sector and housing (SSLPH) based on environment activities are statistical significant 1% and 5%. Only one variable of transport and communication (TC) in financial economic activates is statistical significant at 1% and 5% , but all variables community, social and personal (CSP) , cultural and religious affairs (CRA) and social security and welfare (SSW) in social activities are statistical significant at 1% 5% and 10% , finally , also the multiple regression test run of all variables of green logistics activities and each monetary expansion indicators and found there are a statistical significant at 1% and 5%, .The study recommends that should be attention with financial economic activities as a quantitative standard contributes to build the green logistic by diagnosed the priorities and existing economic and financial system that contributes of sustainable development system in the country

  15. Sustainability via Active Garden Education (SAGE: results from two feasibility pilot studies

    Directory of Open Access Journals (Sweden)

    Rebecca E. Lee

    2017-03-01

    Full Text Available Abstract Background Low physical activity (PA and fruit and vegetable (F&V consumption in early childhood are continued public health challenges. This manuscript describes outcomes from two pilot studies for Sustainability via Active Garden Education (SAGE, a program designed to increase PA and F&V consumption among 3 to 5 year old children. Methods SAGE was developed using community-based participatory research (CBPR and delivered to children (N = 89 in early care and education centers (ECEC, N = 6 in two US cities. Children participated in 12 one-hour sessions that included songs, games, and interactive learning activities involving garden maintenance and taste tests. We evaluated reach, efficacy, adoption, implementation, and potential for maintenance of SAGE following the RE-AIM framework. Reach was evaluated by comparing demographic characteristics among SAGE participants and residents of target geographic areas. Efficacy was evaluated with accelerometer-measured PA, F&V consumption, and eating in the absence of hunger among children, parenting practices regarding PA, and home availability of F&V. Adoption was evaluated by the number of ECEC that participated relative to the number of ECEC that were recruited. Implementation was evaluated by completion rates of planned SAGE lessons and activities, and potential for maintenance was evaluated with a parent satisfaction survey. Results SAGE reached ECEC in neighborhoods representing a wide range of socioeconomic status, with participants’ sociodemographic characteristics representing those of the intervention areas. Children significantly increased PA during SAGE lessons compared to usual lessons, but they also consumed more calories in the absence of hunger in post- vs. pre-intervention tests (both p < .05. Parent reports did not suggest changes in F&V consumption, parenting PA practices, or home F&V availability, possibly due to low parent engagement. ECEC had moderate

  16. Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation.

    Science.gov (United States)

    He, Qing-Li; Minn, Il; Wang, Qiaoling; Xu, Peng; Head, Sarah A; Datan, Emmanuel; Yu, Biao; Pomper, Martin G; Liu, Jun O

    2016-09-19

    Triptolide, a key ingredient from the traditional Chinese medicinal plant thunder god vine, which has been used to treat inflammation and autoimmune diseases for centuries, has been shown to be an irreversible inhibitor of the XPB subunit of the transcription factor TFIIH and initiation of RNA polymerase II mediated transcription. The clinical development of triptolide over the past two decades has been limited by its toxicity and low water solubility. Herein, we report the development of a glucose conjugate of triptolide, named glutriptolide, which was intended to target tumor cells overexpressing glucose transporters selectively. Glutriptolide did not inhibit XPB activity in vitro but demonstrated significantly higher cytotoxicity against tumor cells over normal cells with greater water solubility than triptolide. Furthermore, it exhibited remarkable tumor control in vivo, which is likely due to sustained stepwise release of active triptolide within cancer cells. These findings indicate that glutriptolide may serve as a promising lead for developing a new mechanistic class of anticancer drugs. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Principles of sustainable development of the territory and priorities of architectural and urban construction activity

    Science.gov (United States)

    Dontsov, Dmitry; Yushkova, Natalia

    2017-01-01

    The paper is aimed at detecting conceptual conflicts within the architectural and urban construction activity (AUCA), defining their reasons and substantiating ways to decrease adverse effects they caused. Methods of causes and effects analyses are used, as well as evolutional and comparative analyses. They allow defining the laws to form activity model in modern environment, whose elements are ranked. Relevance of the paper is based on defining scientific and theoretical grounds of necessity to improve methodology of AUCA via its adaption to the imperatives of state management. System analyses enabled to prove practicability of considering factors of institution environment for reorganization of the model of AUCA, which provide the fullest implementation of sustainable development principles. It was proved that territorial planning is not only the leading type of AUCA, but also integrator for functioning structures of state management within planning of social and economic development. As main result of the paper consist in detection of the perspective ways for evolution of modern methodology due to increasing interdisciplinary aspect leading to the qualitative renewal of territorial management principles.

  18. Prothrombin fragment 1+2 in urine as an indicator of sustained coagulation activation after total hip arthroplasty

    DEFF Research Database (Denmark)

    Borris, L.C.; Breindahl, M.; Ryge, C.

    2007-01-01

    Purpose: Prothrombin fragment 1 + 2 measured in spot urine (uF1 + 2) is an indicator of thrombin generation. We examined whether measured levels of uF1 + 2 can be used to differentiate between patients who do and do not acquire sustained coagulation activation after total hip arthroplasty (THA...

  19. Mapping Research Activities and Technologies for Sustainability and Environmental Studies--A Case Study at University Level

    Science.gov (United States)

    Hara, Keishiro; Uwasu, Michinori; Kurimoto, Shuji; Yamanaka, Shinsuke; Umeda, Yasushi; Shimoda, Yoshiyuki

    2013-01-01

    Systemic understanding of potential research activities and available technology seeds at university level is an essential condition to promote interdisciplinary and vision-driven collaboration in an attempt to cope with complex sustainability and environmental problems. Nonetheless, any such practices have been hardly conducted at universities…

  20. Feasibility of Conducting a Randomized Trial to Promote Healthy Eating, Active Play and Sustainability Awareness in Early Childhood Curricula

    Science.gov (United States)

    Morris, Heather; Skouteris, Helen; Edwards, Susan; Rutherford, Leonie Margaret; Cutter-Mackenzie, Amy; O'Connor, Amanda; Mantilla, Ana; Huang, Terry TK; Lording, Kate Marion; Williams-Smith, Janet

    2016-01-01

    We sought to evaluate the feasibility of conducting a randomized trial to evaluate the efficacy of a preschool/kindergarten curriculum intervention designed to increase 4-year-old children's knowledge of healthy eating, active play and the sustainability consequences of their food and toy choices. Ninety intervention and 65 control parent/child…

  1. Sustainable bio kerosene: Process routes and industrial demonstration activities in aviation biofuels

    International Nuclear Information System (INIS)

    Chiaramonti, David; Prussi, Matteo; Buffi, Marco; Tacconi, Daniela

    2014-01-01

    Highlights: • Routes to aviation biofuels are examined, focusing on drop-in biofuels, capable of high blend levels with fossil kerosene. • Industrial demonstration activities are reported. • Used cooking oil is considered as alternative sustainable biomass feedstock for paraffinic fuel production. - Abstract: Alternative fuels are expected to play a major role in EU in the coming years due European Directives on the promotion of renewable energies and reduction of greenhouse gas emissions in transports. However, while in road transports a variety of possible renewable fuels (mainly biofuels, but also electricity) can be considered, in aviation only high quality paraffinic biofuels can be adopted. This means that biomass must be converted through advanced processes into pure hydrocarbon fuels, fully compatible with the existing systems. The aviation sector is responsible for the 2% of the world anthropogenic CO 2 emissions and the 10% of the fuel consumption: airlines’ costs for fuel reach 30% of operating costs. In addition, the aviation traffic is expected to double within 15 years from 2012, while fuel consumption and CO 2 emissions should double in 25 years. Thus, more than 2 billion people and 40 Mt of good/cargo will have to be moved every year. In this context, the EU Flightpath set a target of 2 Mt per year for aviation alternative fuel by 2020 (i.e. 4% of annual fuel consumption). New processes towards bio-hydrocarbons are being developed, demonstrated and soon industrialized. The present work explores the possible routes from biomass feedstock to sustainable paraffinic fuels, either through bio or thermo-chemical processes, as well as discusses those more mature, focusing on industrial demonstration initiatives. In fact, while the number of possible options towards paraffinic biofuel production is very large, and covers both thermochemical and biochemical routes, as well as hybrid one, only two pathways are today ready for testing a significant

  2. Chlorogenic acid loaded chitosan nanoparticles with sustained release property, retained antioxidant activity and enhanced bioavailability

    Directory of Open Access Journals (Sweden)

    Ilaiyaraja Nallamuthu

    2015-06-01

    Full Text Available In this study, chlorogenic acid (CGA, a phenolic compound widely distributed in fruits and vegetables, was encapsulated into chitosan nanoparticles by ionic gelation method. The particles exhibited the size and zeta potential of 210 nm and 33 mV respectively. A regular, spherical shaped distribution of nanoparticles was observed through scanning electron microscopy (SEM and the success of entrapment was confirmed by FTIR analysis. The encapsulation efficiency of CGA was at about 59% with the loading efficiency of 5.2%. In vitro ABTS assay indicated that the radical scavenging activity of CAG was retained in the nanostructure and further, the release kinetics study revealed the burst release of 69% CGA from nanoparticles at the end of 100th hours. Pharmacokinetic analysis in rats showed a lower level of Cmax, longer Tmax, longer MRT, larger AUC0–t and AUC0–∞ for the CGA nanoparticles compared to free CGA. Collectively, these results suggest that the synthesised nanoparticle with sustained release property can therefore ease the fortification of food-matrices targeted for health benefits through effective delivery of CGA in body.

  3. Repeated Activation of a CS-US-Contingency Memory Results in Sustained Conditioned Responding.

    Science.gov (United States)

    Joos, Els; Vansteenwegen, Debora; Vervliet, Bram; Hermans, Dirk

    2013-01-01

    Individuals seem to differ in conditionability, i.e., the ease by which the contingent presentation of two stimuli will lead to a conditioned response. In contemporary learning theory, individual differences in the etiology and maintenance of anxiety disorders are, among others, explained by individual differences in temperamental variables (Mineka and Zinbarg, 2006). One such individual difference variable is how people process a learning experience when the conditioning stimuli are no longer present. Repeatedly thinking about the conditioning experience, as in worry or rumination, might prolong the initial (fear) reactions and as such, might leave certain individuals more vulnerable to developing an anxiety disorder. However, in human conditioning research, relatively little attention has been devoted to the processing of a memory trace after its initial acquisition, despite its potential influences on subsequent performance. Post-acquisition processing can be induced by mental reiteration of a conditioned stimulus-unconditioned stimulus (CS-US)-contingency. Using a human conditioned suppression paradigm, we investigated the effect of repeated activations of a CS-US-contingency memory on the level of conditioned responding at a later test. Results of three experiments showed more sustained responding to a "rehearsed" CS+ as compared to a "non-rehearsed" CS+. Moreover, the second experiment showed no effect of rehearsal when only the CS was rehearsed instead of the CS-US-contingency. The third experiment demonstrated that mental CS-US-rehearsal has the same effect regardless of whether it was cued by the CS and a verbal reference to the US or by a neutral signal, making the rehearsal "purely mental." In sum, it was demonstrated that post-acquisition activation of a CS-US-contingency memory can impact conditioned responding, underlining the importance of post-acquisition processes in conditioning. This might indicate that individuals who are more prone to mentally

  4. Repeated activation of a CS-US-contingency memory results in sustained conditioned responding

    Directory of Open Access Journals (Sweden)

    Els eJoos

    2013-05-01

    Full Text Available Individuals seem to differ in conditionability, i.e., the ease by which the contingent presentation of two stimuli will lead to a conditioned response. In contemporary learning theory, individual differences in the etiology and maintenance of anxiety disorders are, among others, explained by individual differences in temperamental variables (Mineka & Zinbarg, 2006. One such individual difference variable is how people process a learning experience when the conditioning stimuli are no longer present. Repeatedly thinking about the conditioning experience, as in worry or rumination, might prolong the initial (fear reactions and as such, might leave certain individuals more vulnerable to developing an anxiety disorder.However, in human conditioning research, relatively little attention has been devoted to the processing of a memory trace after its initial acquisition, despite its potential influences on subsequent performance. Post-acquisition processing can be induced by mental reiteration of a CS-US-contingency. Using a human conditioned suppression paradigm, we investigated the effect of repeated activations of a CS-US-contingency memory on the level of conditioned responding at a later test. Results of three experiments showed more sustained responding to a ‘rehearsed’ CS+ as compared to a ‘non-rehearsed’ CS+. Moreover, the second experiment showed no effect of rehearsal when only the CS was rehearsed instead of the CS-US-contingency. The third experiment demonstrated that mental CS-US-rehearsal has the same effect regardless of whether it was cued by the CS and a verbal reference to the US or by a neutral signal, making the rehearsal ‘purely mental’. In sum, it was demonstrated that post-acquisition activation of a CS-US-contingency memory can impact conditioned responding, underlining the importance of post-acquisition processes in conditioning. This might indicate that individuals who are more prone to mentally rehearse

  5. Repeated Activation of a CS-US-Contingency Memory Results in Sustained Conditioned Responding

    Science.gov (United States)

    Joos, Els; Vansteenwegen, Debora; Vervliet, Bram; Hermans, Dirk

    2013-01-01

    Individuals seem to differ in conditionability, i.e., the ease by which the contingent presentation of two stimuli will lead to a conditioned response. In contemporary learning theory, individual differences in the etiology and maintenance of anxiety disorders are, among others, explained by individual differences in temperamental variables (Mineka and Zinbarg, 2006). One such individual difference variable is how people process a learning experience when the conditioning stimuli are no longer present. Repeatedly thinking about the conditioning experience, as in worry or rumination, might prolong the initial (fear) reactions and as such, might leave certain individuals more vulnerable to developing an anxiety disorder. However, in human conditioning research, relatively little attention has been devoted to the processing of a memory trace after its initial acquisition, despite its potential influences on subsequent performance. Post-acquisition processing can be induced by mental reiteration of a conditioned stimulus-unconditioned stimulus (CS-US)-contingency. Using a human conditioned suppression paradigm, we investigated the effect of repeated activations of a CS-US-contingency memory on the level of conditioned responding at a later test. Results of three experiments showed more sustained responding to a “rehearsed” CS+ as compared to a “non-rehearsed” CS+. Moreover, the second experiment showed no effect of rehearsal when only the CS was rehearsed instead of the CS-US-contingency. The third experiment demonstrated that mental CS-US-rehearsal has the same effect regardless of whether it was cued by the CS and a verbal reference to the US or by a neutral signal, making the rehearsal “purely mental.” In sum, it was demonstrated that post-acquisition activation of a CS-US-contingency memory can impact conditioned responding, underlining the importance of post-acquisition processes in conditioning. This might indicate that individuals who are more prone

  6. Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host.

    Directory of Open Access Journals (Sweden)

    Shirley Luckhart

    2013-02-01

    Full Text Available The overexpression of activated, myristoylated Akt in the midgut of female transgenic Anopheles stephensi results in resistance to infection with the human malaria parasite Plasmodium falciparum but also decreased lifespan. In the present study, the understanding of mitochondria-dependent midgut homeostasis has been expanded to explain this apparent paradox in an insect of major medical importance. Given that Akt signaling is essential for cell growth and survival, we hypothesized that sustained Akt activation in the mosquito midgut would alter the balance of critical pathways that control mitochondrial dynamics to enhance parasite killing at some cost to survivorship. Toxic reactive oxygen and nitrogen species (RNOS rise to high levels in the midgut after blood feeding, due to a combination of high NO production and a decline in FOXO-dependent antioxidants. Despite an apparent increase in mitochondrial biogenesis in young females (3 d, energy deficiencies were apparent as decreased oxidative phosphorylation and increased [AMP]/[ATP] ratios. In addition, mitochondrial mass was lower and accompanied by the presence of stalled autophagosomes in the posterior midgut, a critical site for blood digestion and stem cell-mediated epithelial maintenance and repair, and by functional degradation of the epithelial barrier. By 18 d, the age at which An. stephensi would transmit P. falciparum to human hosts, mitochondrial dysfunction coupled to Akt-mediated repression of autophagy/mitophagy was more evident and midgut epithelial structure was markedly compromised. Inhibition of RNOS by co-feeding of the nitric-oxide synthase inhibitor L-NAME at infection abrogated Akt-dependent killing of P. falciparum that begins within 18 h of infection in 3-5 d old mosquitoes. Hence, Akt-induced changes in mitochondrial dynamics perturb midgut homeostasis to enhance parasite resistance and decrease mosquito infective lifespan. Further, quality control of mitochondrial

  7. Assessment of the Impact of Business Activity in Sustainability Terms. Empirical Confirmation of Its Determination in Spanish Companies

    Directory of Open Access Journals (Sweden)

    María Luisa Pajuelo Moreno

    2013-05-01

    Full Text Available Because the issue of sustainability presents urgent problems crucial to the future of mankind, there has been serious discussion of the role accounting should play. In this context, a new line of research, still at a relatively unexplored, embryonic stage, has arisen, which tries to establish measurement of business sustainability and so compensate for the lack of information currently existing about the net impact of the company’s activity. Full Cost Accounting could allow sustainability to be translated into the language of business, together with analysis and comparison of its progress, so it might be the most appropriate vehicle for more participatory, democratic accounting, with greater dialogue, giving the accountant a much more active role, this being necessary in order to generalize the research, development and use. To analyze the current situation, a survey of 192 Spanish companies was carried out to obtain at first hand the perception of strategic positioning adopted with regard to Sustainable Development, measurement of the contribution of business activity to its achievement and the rendering of accounts carried out.

  8. No difference in the level of physical activity between children who have or have never sustained a fracture.

    Science.gov (United States)

    Randsborg, P-H; Røtterud, J H

    2017-12-01

    This study investigates whether children with an acute fracture have a different level of physical activity compared to children who have never sustained a fracture, as measured by the Physical Activity Questionnaire for older children (PAQ-C). The PAQ-C scores of 683 children (295 girls) aged 6-12 years (mean age 9.4 years) who presented to our institution with an acute fracture were compared to the PAQ-C scores of 151 random children (81 girls) aged 6-12 years (mean 9.1 years) in the same area who had never sustained a fracture. Multivariate regression analysis was employed, controlling for age and gender. The mean PAQ-C score of the children who presented to the institution with an acute fracture was 2.85 (95% confidence interval [CI], 2.80-2.91). For the children who had never sustained a fracture, the mean PAQ-C score was 2.78 (95% CI, 2.69-2.87). If there is a true difference in the level of physical activity between children who have or have never sustained a fracture, the PAQ-C questionnaire is not sensitive enough to identify it. © 2016 The Authors. Scandinavian Journal of Medicine & Science in Sports Published by John Wiley & Sons Ltd.

  9. Physical Activity through Sustainable Transport Approaches (PASTA): a study protocol for a multicentre project.

    Science.gov (United States)

    Gerike, Regine; de Nazelle, Audrey; Nieuwenhuijsen, Mark; Panis, Luc Int; Anaya, Esther; Avila-Palencia, Ione; Boschetti, Florinda; Brand, Christian; Cole-Hunter, Tom; Dons, Evi; Eriksson, Ulf; Gaupp-Berghausen, Mailin; Kahlmeier, Sonja; Laeremans, Michelle; Mueller, Natalie; Orjuela, Juan Pablo; Racioppi, Francesca; Raser, Elisabeth; Rojas-Rueda, David; Schweizer, Christian; Standaert, Arnout; Uhlmann, Tina; Wegener, Sandra; Götschi, Thomas

    2016-01-07

    Only one-third of the European population meets the minimum recommended levels of physical activity (PA). Physical inactivity is a major risk factor for non-communicable diseases. Walking and cycling for transport (active mobility, AM) are well suited to provide regular PA. The European research project Physical Activity through Sustainable Transport Approaches (PASTA) pursues the following aims: (1) to investigate correlates and interrelations of AM, PA, air pollution and crash risk; (2) to evaluate the effectiveness of selected interventions to promote AM; (3) to improve health impact assessment (HIA) of AM; (4) to foster the exchange between the disciplines of public health and transport planning, and between research and practice. PASTA pursues a mixed-method and multilevel approach that is consistently applied in seven case study cities. Determinants of AM and the evaluation of measures to increase AM are investigated through a large scale longitudinal survey, with overall 14,000 respondents participating in Antwerp, Barcelona, London, Örebro, Rome, Vienna and Zurich. Contextual factors are systematically gathered in each city. PASTA generates empirical findings to improve HIA for AM, for example, with estimates of crash risks, factors on AM-PA substitution and carbon emissions savings from mode shifts. Findings from PASTA will inform WHO's online Health Economic Assessment Tool on the health benefits from cycling and/or walking. The study's wide scope, the combination of qualitative and quantitative methods and health and transport methods, the innovative survey design, the general and city-specific analyses, and the transdisciplinary composition of the consortium and the wider network of partners promise highly relevant insights for research and practice. Ethics approval has been obtained by the local ethics committees in the countries where the work is being conducted, and sent to the European Commission before the start of the survey. The PASTA website

  10. A comparison between effectiveness of three types of music on memory activity and sustained attention in schizophrenic patients

    Directory of Open Access Journals (Sweden)

    Narges bahmany

    2014-10-01

    Full Text Available Background: schizophrenia is a psychiatric disorder in which a lot of cognitive functions including memory, attention, motor skills, executive functions and intelligence are compromised. Numerous empirical studies showed that schizophrenic patients have problem in sustain retention and memory activity. The objective of this study was a comparison between effectiveness of three types of music on memory activity and sustain retention in schizophrenic patients. Material and Methods: A total of 60 schizophrenic patients (30 males , 30 females 18-48 years old were selected from available sampling frame. Participants were otherwise healthy except for schizophrenia. Wechsler Memory Scale and cognitive diagnostic battery Kay test were taken from all subjects. Then patients were randomly divided into three experimental groups (Iranian classic, western classic and pop music and three control groups. There were 10 participants (5 male, 5 female in each group. After taking these tests, music therapy course was performed on experimental groups. After music therapy sessions were completed, tests were taken again from groups. Results: Covariance analysis results indicated that music therapy is overall effective on memory activity. But type of music had no effect in improving memory activity. There wasn’t significant difference between groups considering type of music. Furthermore, covariance analysis showed that music therapy is totally effective on sustain retention and type of music is effective in this intervention. Pop music had the most effectiveness on schizophrenic patients in improving sustain retention. Conclusion: Performing music therapy improves memory and retention. More over, using pop music particularly has the most effect in improving sustain retention in schizophrenic patients.

  11. Hippocampal subfield and medial temporal cortical persistent activity during working memory reflects ongoing encoding

    Directory of Open Access Journals (Sweden)

    Rachel K Nauer

    2015-03-01

    Full Text Available Previous neuroimaging studies support a role for the medial temporal lobes (MTL in maintaining novel stimuli over brief working memory (WM delays, and suggest delay period activity predicts subsequent memory. Additionally, slice recording studies have demonstrated neuronal persistent spiking in entorhinal cortex (EC, perirhinal cortex (PrC, and hippocampus (CA1, CA3, subiculum. These data have led to computational models that suggest persistent spiking in parahippocampal regions could sustain neuronal representations of sensory information over many seconds. This mechanism may support both WM maintenance and encoding of information into long term episodic memory. The goal of the current study was to use high-resolution fMRI to elucidate the contributions of the MTL cortices and hippocampal subfields to WM maintenance as it relates to later episodic recognition memory. We scanned participants while they performed a delayed match to sample task with novel scene stimuli, and assessed their memory for these scenes post-scan. We hypothesized stimulus-driven activation that persists into the delay period—a putative correlate of persistent spiking—would predict later recognition memory. Our results suggest sample and delay period activation in the parahippocampal cortex (PHC, PrC, and subiculum (extending into DG/CA3 and CA1 was linearly related to increases in subsequent memory strength. These data extend previous neuroimaging studies that have constrained their analysis to either the sample or delay period by modeling these together as one continuous ongoing encoding process, and support computational frameworks that predict persistent activity underlies both WM and episodic encoding.

  12. Sustainable waste management by production of activated carbon from agroforestry residues

    Directory of Open Access Journals (Sweden)

    Victor Ntuli

    2013-01-01

    Full Text Available Agroforestry waste presents a problem for disposal and negatively impacts on the environment if left to rot or burn. The aim of this study was to reduce environmental problems associated with agroforestry waste by promoting the innovative use of such waste in the production of activated carbons (ACs using a low-cost production technique, and ultimately delivering more affordable water and effluent treatment adsorbents. Four varieties of ACs from four different agroforestry materials – pine (Pinus contorta cones (PC, Abies (Abies cilicica seeds (AS, maple (Acer ginnala seeds (MS and peach (Prunus persica stones (PS – were prepared by single-step steam pyrolysis and characterised. The raw materials were evaluated for AC yield while the respective ACs were evaluated on the basis of iodine number, phenol specific area, ash content, pH, moisture content and removal of metal ions, nitrates and sulphates from aqueous solution. The AC yields for PS, PC, AS and MS were found to be 23.0%, 18.0%, 17.8% and 14.6%, respectively. The yield for PS (23% is within the specified commercial limits of 20% to 40%. The phenol specific areas of the ACs ranged between 381 m2/g and 415 m2/g higher than the commercial lower limit (300 m2/g generally specified. The ACs also showed the capacity to remove heavy metal ions from their aqueous solutions. Removal of both nitrates and sulphates in raw water was greater than 50%. Although no quantitative analysis has been performed to date, it is envisaged that the production of AC from agroforestry wastes can contribute to the sustainable management of environmental pollution by these residues and the concomitant delivery of cheaper adsorbents.

  13. Sustainable Transportation

    DEFF Research Database (Denmark)

    Hall, Ralph P.; Gudmundsson, Henrik; Marsden, Greg

    2014-01-01

    The transportation system is the backbone of economic and social progress and the means by which humans access goods and services and connect with one another. Yet, as the scale of transportation activities has grown worldwide, so too have the negative environmental, social, and economic impacts...... that relate to the construction and maintenance of transportation infrastructure and the operation or use of the different transportation modes. The concept of sustainable transportation emerged in response to these concerns as part of the broader notion of sustainable development. Given the transportation...... sector’s significant contribution to global challenges such as climate change, it is often said that sustainable development cannot be achieved without sustainable transportation....

  14. Sustainable Consumption

    DEFF Research Database (Denmark)

    Røpke, Inge

    2015-01-01

    The intention of this chapter is to explore the role of consumption and consumers in relation to sustainability transition processes and wider systemic transformations. In contrast to the individualistic focus in much research on sustainable consumption, the embeddedness of consumption activities...... in wider social, economic and technological frameworks is emphasised. In particular, the chapter is inspired by practice theory and transition theory. First, various trends in consumption are outlined to highlight some of the challenges for sustainability transitions. Then, it is discussed how consumption...... patterns are shaped over time and what should be considered in sustainability strategies. While discussions on consumption often take their point of departure in the perspective of the individual and then zoom to the wider context, the present approach is the opposite. The outline starts with the basic...

  15. Ship Acquisition of Shipping Companies by Sale & Purchase Activities for Sustainable Growth: Exploratory Fuzzy-AHP Application

    Directory of Open Access Journals (Sweden)

    Keun-Sik Park

    2018-05-01

    Full Text Available Strengthening sale and purchase (S&P capacity has become a fundamental requirement for sustainable growth and corporate competitiveness in the modern shipping market. However, there is a lack of research related to S&P and its priority when shipping companies attempt to implement ship acquisition through S&P activities. To fill this gap, this paper conducts an empirical analysis to analyze priority factors during the acquisition of second-hand ships from the perspective of shipping companies. Business criteria are considered to be the most important factors in the analysis of the priority of ship acquisition and investment in shipping companies. To the best of our knowledge, this research is the first exploration covering Korean shipping companies’ ship acquisition through S&P activities. This study is expected to contribute to the better understanding of the role of S&P in ensuring the sustainability of shipping companies and to provide stakeholders with valuable insights.

  16. Harmonic-resonator-based triboelectric nanogenerator as a sustainable power source and a self-powered active vibration sensor.

    Science.gov (United States)

    Chen, Jun; Zhu, Guang; Yang, Weiqing; Jing, Qingshen; Bai, Peng; Yang, Ya; Hou, Te-Chien; Wang, Zhong Lin

    2013-11-13

    A harmonic-resonator-based triboelectric nanogenerator (TENG) is presented as a sustainable power source and an active vibration sensor. It can effectively respond to vibration frequencies ranging from 2 to 200 Hz with a considerably wide working bandwidth of 13.4 Hz. This work not only presents a new principle in the field of vibration energy harvesting but also greatly expands the applicability of TENGs. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Education activities for environment and sustainability: A Snapshot of eight New South Wales councils

    Directory of Open Access Journals (Sweden)

    Jade Herriman

    2010-07-01

    Full Text Available This paper describes in brief the findings of a research project undertaken by the Institute for Sustainable Futures (ISF at the University of Technology, Sydney, Australia. The research was commissioned by and undertaken on behalf of the New South Wales (NSW Department of Environment, Climate Change and Water (DECCW. The aim of the project was to investigate current practices of environmental and sustainability education and engagement within local government in NSW. The research was commissioned by DECCW as the preliminary phase of a larger project that the department is planning to undertake, commencing in 2010.

  18. Competitiveness and sustainability of HRM activities in Croatia –CRANET survey results

    OpenAIRE

    Nina Pološki Vokić

    2015-01-01

    The aim of the paper is to assess whether HRM practices in Croatia, as the newest European Union (EU) member country with only cca 20 years of free market economy which implies the change in the HRM philosophy, is heading towards more competitive or more sustainable HRM. In the theoretical part of the paper the characteristics of competitive HRM and sustainable HRM are provided. In the empirical part of the paper, using CRANET methodology, the survey of HRM practices in Croatia has been condu...

  19. Unique Transcriptional Profile of Sustained Ligand-Activated Preconditioning in Pre- and Post-Ischemic Myocardium

    Science.gov (United States)

    Ashton, Kevin J.; Tupicoff, Amanda; Williams-Pritchard, Grant; Kiessling, Can J.; See Hoe, Louise E.; Headrick, John P.; Peart, Jason N.

    2013-01-01

    Background Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3–5 days of opioid receptor (OR) agonism induces persistent protection against ischemia-reperfusion (I-R) injury in young and aged hearts, and is mechanistically distinct from conventional preconditioning responses. We thus applied unbiased gene-array interrogation to identify molecular effects of SLP in pre- and post-ischemic myocardium. Methodology/Principal Findings Male C57Bl/6 mice were implanted with 75 mg morphine or placebo pellets for 5 days. Resultant SLP did not modify cardiac function, and markedly reduced dysfunction and injury in perfused hearts subjected to 25 min ischemia/45 min reperfusion. Microarray analysis identified 14 up- and 86 down-regulated genes in normoxic hearts from SLP mice (≥1.3-fold change, FDR≤5%). Induced genes encoded sarcomeric/contractile proteins (Myh7, Mybpc3,Myom2,Des), natriuretic peptides (Nppa,Nppb) and stress-signaling elements (Csda,Ptgds). Highly repressed genes primarily encoded chemokines (Ccl2,Ccl4,Ccl7,Ccl9,Ccl13,Ccl3l3,Cxcl3), cytokines (Il1b,Il6,Tnf) and other proteins involved in inflammation/immunity (C3,Cd74,Cd83, Cd86,Hla-dbq1,Hla-drb1,Saa1,Selp,Serpina3), together with endoplasmic stress proteins (known: Dnajb1,Herpud1,Socs3; putative: Il6, Gadd45g,Rcan1) and transcriptional controllers (Egr2,Egr3, Fos,Hmox1,Nfkbid). Biological themes modified thus related to inflammation/immunity, together with cellular/cardiovascular movement and development. SLP also modified the transcriptional response to I-R (46 genes uniquely altered post-ischemia), which may influence later infarction/remodeling. This included up-regulated determinants of cellular resistance to oxidant (Mgst3,Gstm1,Gstm2) and other forms of stress (Xirp1,Ankrd1,Clu), and repression of stress-response genes (Hspa1a,Hspd1,Hsp90aa,Hsph1,Serpinh1) and Txnip. Conclusions Protection via SLP is associated with transcriptional repression of inflammation/immunity, up

  20. Unique transcriptional profile of sustained ligand-activated preconditioning in pre- and post-ischemic myocardium.

    Directory of Open Access Journals (Sweden)

    Kevin J Ashton

    Full Text Available BACKGROUND: Opioidergic SLP (sustained ligand-activated preconditioning induced by 3-5 days of opioid receptor (OR agonism induces persistent protection against ischemia-reperfusion (I-R injury in young and aged hearts, and is mechanistically distinct from conventional preconditioning responses. We thus applied unbiased gene-array interrogation to identify molecular effects of SLP in pre- and post-ischemic myocardium. METHODOLOGY/PRINCIPAL FINDINGS: Male C57Bl/6 mice were implanted with 75 mg morphine or placebo pellets for 5 days. Resultant SLP did not modify cardiac function, and markedly reduced dysfunction and injury in perfused hearts subjected to 25 min ischemia/45 min reperfusion. Microarray analysis identified 14 up- and 86 down-regulated genes in normoxic hearts from SLP mice (≥1.3-fold change, FDR≤5%. Induced genes encoded sarcomeric/contractile proteins (Myh7, Mybpc3,Myom2,Des, natriuretic peptides (Nppa,Nppb and stress-signaling elements (Csda,Ptgds. Highly repressed genes primarily encoded chemokines (Ccl2,Ccl4,Ccl7,Ccl9,Ccl13,Ccl3l3,Cxcl3, cytokines (Il1b,Il6,Tnf and other proteins involved in inflammation/immunity (C3,Cd74,Cd83, Cd86,Hla-dbq1,Hla-drb1,Saa1,Selp,Serpina3, together with endoplasmic stress proteins (known: Dnajb1,Herpud1,Socs3; putative: Il6, Gadd45g,Rcan1 and transcriptional controllers (Egr2,Egr3, Fos,Hmox1,Nfkbid. Biological themes modified thus related to inflammation/immunity, together with cellular/cardiovascular movement and development. SLP also modified the transcriptional response to I-R (46 genes uniquely altered post-ischemia, which may influence later infarction/remodeling. This included up-regulated determinants of cellular resistance to oxidant (Mgst3,Gstm1,Gstm2 and other forms of stress (Xirp1,Ankrd1,Clu, and repression of stress-response genes (Hspa1a,Hspd1,Hsp90aa,Hsph1,Serpinh1 and Txnip. CONCLUSIONS: Protection via SLP is associated with transcriptional repression of inflammation/immunity, up

  1. Expanding entrepreneurial, innovative and sustainable (EIS) ecosystems: A cultural-historical activity theory perspective

    NARCIS (Netherlands)

    Audhoe, Romano; Thompson, N.A.; Verduyn, Karen; Leitão, João; Alves, Helena; Krueger, Norris; Park, Jacob

    2018-01-01

    The value of Entrepreneurial, Innovative and Sustainable (EIS) ecosystems has seen increasing recognition from policymakers and researchers alike. Like-minded policymakers employing New Public Management (NPM) understand that the intricate links between diverse EIS stakeholders play a vital role in

  2. Towards fusion energy as a sustainable energy source: Activities at DTU Physics

    DEFF Research Database (Denmark)

    Rasmussen, Jesper; Christensen, Alexander Simon; Dam, Magnus

    2014-01-01

    a fusion plasma) and to confine it within magnetic fields. Learning how such plasmas behave and can be controlled is a crucial step towards realizing fusion as a sustainable energy source.At the Plasma Physics and Fusion Energy (PPFE) section at DTU Physics, we are exploring these issues,focusing on areas...

  3. Is ‘Bio-Based’ Activity a Panacea for Sustainable Competitive Growth?

    NARCIS (Netherlands)

    Philippidis, George; M’Barek, Robert; Ferrari, Emanuele

    2016-01-01

    Taking a European Union focus, this paper explicitly models competing uses of biomass to quantify its contribution toward a sustainable low carbon model of economic growth. To this end, a state-of-the-art multisector multiregion modelling tool is combined with a specially developed bio-based variant

  4. Popes in the Pizza: Analyzing Activity Reports to Create and Sustain a Strategic Plan

    Science.gov (United States)

    Sweet, Charlie; Blythe, Hal; Keeley, E. J.; Forsyth, Ben

    2008-01-01

    This article presents a practical methodology for creating and sustaining strategic planning, the task analysis. Utilizing our Teaching & Learning Center Strategic Plan as a model, we demonstrate how working with a weekly status report provides a comprehensive listing of detail necessary to analyze and revise the plan. The new methodology is…

  5. Sustainability: Teaching an Interdisciplinary Threshold Concept through Traditional Lecture and Active Learning

    Science.gov (United States)

    Levintova, Ekaterina M.; Mueller, Daniel W.

    2015-01-01

    One of the difficulties in teaching global sustainability in the introductory political science classes is the different emphases placed on this concept and the absence of the consensus on where the overall balance between environmental protection, economic development, and social justice should reside. Like many fuzzy concepts with which students…

  6. An Experience-Based Learning Framework: Activities for the Initial Development of Sustainability Competencies

    Science.gov (United States)

    Caniglia, Guido; John, Beatrice; Kohler, Martin; Bellina, Leonie; Wiek, Arnim; Rojas, Christopher; Laubichler, Manfred D.; Lang, Daniel

    2016-01-01

    Purpose: This paper aims to present an experience-based learning framework that provides a bottom-up, student-centered entrance point for the development of systems thinking, normative and collaborative competencies in sustainability. Design/methodology/approach: The framework combines mental mapping with exploratory walking. It interweaves…

  7. Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus

    DEFF Research Database (Denmark)

    Harvey, Brian H; Oosthuizen, Frasia; Brand, Linda

    2004-01-01

    . The NOS isoform involved, and the role of stress-mediated corticosterone release in NOS activation, was verified with the administration of selective iNOS and nNOS inhibitors, aminoguanidine (50 mg/kg/day i.p.) and 7-nitroindazole (12.5 mg/kg/day i.p.), and the steroid synthesis inhibitor, ketoconazole...... (24 mg/kg/day i.p.), administered for 21 days prior to and during the stress procedure. RESULTS: Stress evoked a sustained increase in NOS activity, but reduced NMDA receptor density and total GABA levels. Aminoguanidine or ketoconazole, but not 7-nitroindazole or saline, blocked stress-induced NOS...

  8. Sustained availability of trimethoprim in drinking water to achieve higher plasma sulphonamide-trimethoprim antibacterial activity in broilers.

    Science.gov (United States)

    Sumano, H; Hernandez, L; Gutierrez, L; Bernad-Bernad, M J

    2005-02-01

    (1) In order to make trimethoprim (TMP) available to broilers throughout the day, a sustained release formulation (SRF) of the drug in the form of granules was added to the water tank that supplies drinking water. (2) Broilers were initially dosed with sulphachloropiridazine-TMP (SCP-TMP 5:1) and then further medicated throughout the day, achieving in the end a dose of 30 mg/kg each of SCP and TMP (group A). Group B received a preparation with the same dose of SCP and TMP (1:1) as group A, but administered as a single dose without the SRF of TMP. Group C received the customary SCP-TMP 5:1 preparation (30 and 6 mg/kg, respectively). Water tanks were completely consumed in 3 to 4 h. (3) Broilers were bled at different times and concentration of antibacterial activity in serum determined by correlating the composite antibacterial activity of SCP and TMP with actual concentrations of these drugs by means of a microbiological agar diffusion assay. (4) Time vs serum concentrations of activity were higher in group B; the increments in the maximum serum concentration for group B over groups A and C being 39 and 67%, respectively. (5) However, the sustained concentration of activity over time, measured as the area under the cu)rve, was highest in group A. Group B had higher values for area under the curve than group C. (6) An additional dose of TMP to achieve 30 mg/kg of both SCP and TMP improves the serum concentration of this combination over the customary 5:1 proportion. The best values for sustaining antibacterial activity were obtained using a 1:1 ratio as in group A. The use of a SRF as in group A may translate into better clinical results.

  9. SCOPEOUT: sustainability and spread of quality improvement activities in long-term care- a mixed methods approach.

    Science.gov (United States)

    Cranley, Lisa A; Hoben, Matthias; Yeung, Jasper; Estabrooks, Carole A; Norton, Peter G; Wagg, Adrian

    2018-03-12

    Interventions to improve quality of care for residents of long-term care facilities, and to examine the sustainability and spread of such initiatives, remain a top research priority. The purpose of this exploratory study was to assess the extent to which activities initiated in a quality improvement (QI) collaborative study using care aide led teams were sustained or spread following cessation of the initial project and to identify factors that led to its success. This study used an exploratory mixed methods study design and was conducted in seven residential long-term care facilities in two Canadian provinces. Sustainability and spread of QI activities were assessed by a questionnaire over five time points for 18 months following the collaborative study with staff from both intervention with non-intervention units. Semi-structured interviews were conducted with care managers at six and 12 months. QI team success in applying the QI model was ranked as high, medium, or low using criteria developed by the research team. Descriptive statistics, bivariate analyses, and General Estimating Equations were used to analyze the data. Interview data were analyzed using thematic analysis. In total, 683 surveys were received over the five time periods from 476 unique individuals on a facility unit. Seven managers were interviewed. A total of 533 surveys were analyzed. While both intervention and non-intervention units experienced a decline over time in all outcome measures, this decline was significantly less pronounced on intervention units. Facilities with medium and high success ranking had significantly higher scores in all four outcomes than facilities with a low success ranking. Care aides reported significantly less involvement of others in QI activities, less empowerment and less satisfaction with the quality of their work life than regulated care providers. Manager interviews provided evidence of sustainability of QI activities on the intervention units in four of

  10. Local people's knowledge with regard to land use activities in southwest Madagascar - Conceptual insights for sustainable land management.

    Science.gov (United States)

    Fritz-Vietta, Nadine V M; Tahirindraza, H Stone; Stoll-Kleemann, Susanne

    2017-09-01

    Environmental conditions in the Mahafaly Plateau region in southwest Madagascar are harsh, with a long dry season and a short rainy season. The local people's land use capabilities and skills are adapted to these conditions. Nevertheless, they are currently confronted by drastic climatic changes, including longer dry seasons, which have resulted in food and water scarcities. It is therefore essential to ensure sustainable land management in the region. At present, the main land use activities are agriculture, livestock farming, natural resource collection including timber and non-timber forest products, and the practice of local customs. Land use activities have always resulted in land conversion, yet over time this ecological transformation also leads to the accumulation of knowledge. The aim of the present article is therefore twofold. First, it aims to examine local people's knowledge with regard to land use activities and the transmission of this knowledge from one generation to the next; second, it considers the extent to which local people's knowledge may contribute to the development of sustainable land management. Our research is based on more than 80 qualitative interviews with local inhabitants of the Mahafaly Plateau region. Our analysis of local people's knowledge identifies four categories: ecological knowledge, knowledge related to natural resource usage, knowledge of names, and the interconnection between knowledge and belief. Furthermore, these knowledge categories provide conceptual insights for sustainable land management. Along with the long-term persistence of natural resources and their functions and the satisfaction of basic needs through resource usage, both the recognition of mental images as a regulating mechanism and the maintenance of the relation between the natural and the supernatural world have a role to play in sustainable land management in the study area. Local knowledge transmission processes serve to foster ongoing learning and

  11. Ergonomics and environmental sustainability: a case study of raft fisherman activity at Ponta Negra Beach, Natal-RN.

    Science.gov (United States)

    Celestino, Joyce Elanne Mateus; Bispo, Cristina de Souza; Saldanha, Maria Christine Werba; Mattos, Karen Maria da Costa

    2012-01-01

    This paper aims to present the significance of methods used by the Ergonomic Analysis of Work for the construction of the scenario of craft fishing with rafts, held by 42 fishermen on the beach of Ponta Negra, Natal - RN; and relate the knowledge in ergonomics to environmental aspects / impacts, aiming the sustainability in this activity. This research is characterized as a case study, of the descriptive and exploratory type and of applied nature. To collect data, we used observational methods, in order to expand information about the activity, and interaction, as conversational action and photographic/videos records to clarify points not covered by observation. It was observed problematic as the reduction of fishing productivity, alterations of the sea, difficulty in docking the rafts, and inadequate waste disposal, noting that this activity needs care regarding the use of the environment. The obtained results contributed to the organization of environmental education workshops, seeking to enhance good individual / collective environmental practices focused on the sustainability of the environment in which they live. Add the need for proposals aimed for managing the activity, involving fishermen, institutions and society, to ensure the improvement of the environment, hence the quality of life of the population.

  12. Dissociable Decoding of Spatial Attention and Working Memory from EEG Oscillations and Sustained Potentials.

    Science.gov (United States)

    Bae, Gi-Yeul; Luck, Steven J

    2018-01-10

    In human scalp EEG recordings, both sustained potentials and alpha-band oscillations are present during the delay period of working memory tasks and may therefore reflect the representation of information in working memory. However, these signals may instead reflect support mechanisms rather than the actual contents of memory. In particular, alpha-band oscillations have been tightly tied to spatial attention and may not reflect location-independent memory representations per se. To determine how sustained and oscillating EEG signals are related to attention and working memory, we attempted to decode which of 16 orientations was being held in working memory by human observers (both women and men). We found that sustained EEG activity could be used to decode the remembered orientation of a stimulus, even when the orientation of the stimulus varied independently of its location. Alpha-band oscillations also carried clear information about the location of the stimulus, but they provided little or no information about orientation independently of location. Thus, sustained potentials contain information about the object properties being maintained in working memory, consistent with previous evidence of a tight link between these potentials and working memory capacity. In contrast, alpha-band oscillations primarily carry location information, consistent with their link to spatial attention. SIGNIFICANCE STATEMENT Working memory plays a key role in cognition, and working memory is impaired in several neurological and psychiatric disorders. Previous research has suggested that human scalp EEG recordings contain signals that reflect the neural representation of information in working memory. However, to conclude that a neural signal actually represents the object being remembered, it is necessary to show that the signal contains fine-grained information about that object. Here, we show that sustained voltages in human EEG recordings contain fine-grained information about the

  13. Engineering Sustainability: A Technical Approach to Sustainability

    OpenAIRE

    Rosen, Marc A.

    2012-01-01

    Sustainability is a critically important goal for human activity and development. Sustainability in the area of engineering is of great importance to any plans for overall sustainability given 1) the pervasiveness of engineering activities in societies, 2) their importance in economic development and living standards, and 3) the significant impacts that engineering processes and systems have had, and continue to have, on the environment. Many factors that need to be considered and appropriate...

  14. Integrating Norm Activation Model and Theory of Planned Behavior to Understand Sustainable Transport Behavior: Evidence from China.

    Science.gov (United States)

    Liu, Yuwei; Sheng, Hong; Mundorf, Norbert; Redding, Colleen; Ye, Yinjiao

    2017-12-18

    With increasing urbanization in China, many cities are facing serious environmental problems due to continuous and substantial increase in automobile transportation. It is becoming imperative to examine effective ways to reduce individual automobile use to facilitate sustainable transportation behavior. Empirical, theory-based research on sustainable transportation in China is limited. In this research, we propose an integrated model based on the norm activation model and the theory of planned behavior by combining normative and rational factors to predict individuals' intention to reduce car use. Data from a survey of 600 car drivers in China's three metropolitan areas was used to test the proposed model and hypotheses. Results showed that three variables, perceived norm of car-transport reduction, attitude towards reduction, and perceived behavior control over car-transport reduction, significantly affected the intention to reduce car-transport. Personal norms mediated the relationship between awareness of consequences of car-transport, ascription of responsibility of car-transport, perceived subjective norm for car-transport reduction, and intention to reduce car-transport. The results of this research not only contribute to theory development in the area of sustainable transportation behavior, but also provide a theoretical frame of reference for relevant policy-makers in urban transport management.

  15. Integrating Norm Activation Model and Theory of Planned Behavior to Understand Sustainable Transport Behavior: Evidence from China

    Directory of Open Access Journals (Sweden)

    Yuwei Liu

    2017-12-01

    Full Text Available With increasing urbanization in China, many cities are facing serious environmental problems due to continuous and substantial increase in automobile transportation. It is becoming imperative to examine effective ways to reduce individual automobile use to facilitate sustainable transportation behavior. Empirical, theory-based research on sustainable transportation in China is limited. In this research, we propose an integrated model based on the norm activation model and the theory of planned behavior by combining normative and rational factors to predict individuals’ intention to reduce car use. Data from a survey of 600 car drivers in China’s three metropolitan areas was used to test the proposed model and hypotheses. Results showed that three variables, perceived norm of car-transport reduction, attitude towards reduction, and perceived behavior control over car-transport reduction, significantly affected the intention to reduce car-transport. Personal norms mediated the relationship between awareness of consequences of car-transport, ascription of responsibility of car-transport, perceived subjective norm for car-transport reduction, and intention to reduce car-transport. The results of this research not only contribute to theory development in the area of sustainable transportation behavior, but also provide a theoretical frame of reference for relevant policy-makers in urban transport management.

  16. Water sector fund (CT-hi dro) and wastewater reuse activities: initiatives to promote environment ally sustainable development in Brazil

    International Nuclear Information System (INIS)

    Leitao, S.A.M.

    2005-01-01

    The Brazilian Water Sector Fund (CT-Hidro) is presented as an innovative mechanism to foster the scientific and technological sector of the country as well as a model instrument to promote environmentally sustainable development in Brazil and in other developing countries. CT-Hidro is shown as an instrument that provides support for scientific and technological development research activities in the following areas: experimental technological development, scientific and technological research projects, development of basic industrial technology and implantation of research infrastructure. CT-Hidro is presented as a key mechanism to finance wastewater reuse projects as an imperative action to fight poverty and promote social inclusion in Brazil. The concept of wastewater reuse for beneficial purposes is presented. Its growing importance as an essential part of the planning of the integrated and sustainable water resources management is also evidenced. In this perspective, the need for sanitation, wastewater treatment and its reuse in agriculture for food production are presented as imperative measures that must be taken in Brazil in order to promote sustainable development, fight poverty, improve public health conditions and enhance environmental quality in the country. (author)

  17. Sales Forecasting in the Context of Seasonal Activities and Company Sustainable Growth

    Directory of Open Access Journals (Sweden)

    Ion Stancu

    2015-08-01

    Full Text Available The paper presents the use of the “time series model” to forecast the quarterly and yearly sales for a company with business seasonality. These sales forecasts will represent the fundamental basis for estimating the external financing, using the percentage to sales method. Sales growth rates are afterwards analysed in the context of ensuring a sustainable and self-financed growth. We focus on establishing the forecasted financial structure of the external financial requirements both in the context of using the reinvested profit complemented with credit, maintaining the debt rate constant, and in the context of total internal funding of the company economic growth, from reinvested profit.

  18. No sustained attention differences in a longitudinal randomized trial comparing mindfulness based stress reduction versus active control.

    Directory of Open Access Journals (Sweden)

    Donal G MacCoon

    Full Text Available Mindfulness Based Stress Reduction (MBSR is a secular form of meditation training. The vast majority of the extant literature investigating the health effects of mindfulness interventions relies on wait-list control comparisons. Previous studies have found that meditation training over several months is associated with improvements in cognitive control and attention.We used a visual continuous performance task (CPT to test the effects of eight weeks of mindfulness training on sustained attention by comparing MBSR to the Health Enhancement Program (HEP, a structurally equivalent, active control condition in a randomized, longitudinal design (ClinicalTrials.gov, NCT01301105 focusing on a non-clinical population typical of MBSR participants. Researchers were blind to group assignment. 63 community participants were randomized to either MBSR (n = 31 or HEP (n = 32. CPT analyses were conducted on 29 MBSR participants and 25 HEP participants. We predicted that MBSR would improve visual discrimination ability and sustained attention over time on the CPT compared to HEP, with more home practice associated with greater improvements. Our hypotheses were not confirmed but we did find some evidence for improved visual discrimination similar to effects in partial replication of other research. Our study had sufficient power to demonstrate that intervention groups do not differ in their improvement over time in sustained attention performance. One of our primary predictions concerning the effects of intervention on attentional fatigue was significant but not interpretable.Attentional sensitivity is not affected by mindfulness practice as taught in MBSR, but it is unclear whether mindfulness might positively affect another aspect of attention, vigilance. These results also highlight the relevant procedural modifications required by future research to correctly investigate the role of sustained attention in similar samples.ClinicalTrials.gov, NCT

  19. Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils

    DEFF Research Database (Denmark)

    Sacco, Pasquale; Decleva, Eva; Tentor, Fabio

    2017-01-01

    that butyrate inhibits neutrophil ROS release in a dose and time-dependent fashion. Given the short half-life of butyrate, chitosan/hyaluronan nanoparticles are next designed and developed as controlled release carriers able to provide cells with a long-lasting supply of this SCFA. Notably, while the inhibition...... of neutrophil ROS production by free butyrate declines over time, that of butyrate-loaded chitosan/hyaluronan nanoparticles (B-NPs) is sustained. Additional valuable features of these nanoparticles are inherent ROS scavenger activity, resistance to cell internalization, and mucoadhesiveness. B-NPs appear...

  20. Alkali silica reaction (ASR) in cement free alkali activated sustainable concrete.

    Science.gov (United States)

    2016-12-19

    This report summarizes the findings of an experimental evaluation into alkali silica : reaction (ASR) in cement free alkali-activated slag and fly ash binder concrete. The : susceptibility of alkali-activated fly ash and slag concrete binders to dele...

  1. Neuron to astrocyte communication via cannabinoid receptors is necessary for sustained epileptiform activity in rat hippocampus.

    OpenAIRE

    Coiret Guyllaume; Ster Jeanne; Grewe Benjamin; Wendling Fabrice; Helmchen Fritjof; Gerber Urs; Benquet Pascal

    2012-01-01

    International audience; Astrocytes are integral functional components of synapses, regulating transmission and plasticity. They have also been implicated in the pathogenesis of epilepsy, although their precise roles have not been comprehensively characterized. Astrocytes integrate activity from neighboring synapses by responding to neuronally released neurotransmitters such as glutamate and ATP. Strong activation of astrocytes mediated by these neurotransmitters can promote seizure-like activ...

  2. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules.

    Directory of Open Access Journals (Sweden)

    Takanobu Nagata

    Full Text Available Myocardial ischemia reperfusion injury (IRI adversely affects cardiac performance and the prognosis of patients with acute myocardial infarction. Although myocardial signal transducer and activator of transcription (STAT 3 is potently cardioprotective during IRI, the inhibitory mechanism responsible for its activation is largely unknown. The present study aimed to investigate the role of the myocardial suppressor of cytokine signaling (SOCS-3, an intrinsic negative feedback regulator of the Janus kinase (JAK-STAT signaling pathway, in the development of myocardial IRI. Myocardial IRI was induced in mice by ligating the left anterior descending coronary artery for 1 h, followed by different reperfusion times. One hour after reperfusion, the rapid expression of JAK-STAT-activating cytokines was observed. We precisely evaluated the phosphorylation of cardioprotective signaling molecules and the expression of SOCS3 during IRI and then induced myocardial IRI in wild-type and cardiac-specific SOCS3 knockout mice (SOCS3-CKO. The activation of STAT3, AKT, and ERK1/2 rapidly peaked and promptly decreased during IRI. This decrease correlated with the induction of SOCS3 expression up to 24 h after IRI in wild-type mice. The infarct size 24 h after reperfusion was significantly reduced in SOCS3-CKO compared with wild-type mice. In SOCS3-CKO mice, STAT3, AKT, and ERK1/2 phosphorylation was sustained, myocardial apoptosis was prevented, and the expression of anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1 was augmented. Cardiac-specific SOCS3 deletion led to the sustained activation of cardioprotective signaling molecules including and prevented myocardial apoptosis and injury during IRI. Our findings suggest that SOCS3 may represent a key factor that exacerbates the development of myocardial IRI.

  3. Mucoralean fungi for sustainable production of bioethanol and biologically active molecules.

    Science.gov (United States)

    Satari, Behzad; Karimi, Keikhosro

    2018-02-01

    Mucoralean fungi are suitable microorganisms for the sustainable production of food, fodder, and fuels from inexpensive natural resources. Ethanol-producing Mucorales are particularly advantageous for second-generation ethanol production in comparison to the conventional ethanolic yeasts and bacteria. They are able to ferment a wide range of sugars to a range of valuable products, while they are typically resistance against the inhibitors available in different substrates, including untreated lignocellulosic hydrolysates. In addition to a high ethanol yield, the fungi produce several commercially valuable by-products, including chitosan, microbial oil (mainly polyunsaturated fatty acids), and protein. Moreover, the fungal extracts can replace the expensive nutrients required in fermentation. Besides, their morphologies can be altered from filamentous to yeast like and are adjustable based on the process requirement. The focus of this review is on applying Mucorales in producing ethanol and the biomass by-products thereof.

  4. Sustainable implementation of school-based physical activity: A four-stage Delphi consensus process

    DEFF Research Database (Denmark)

    Johansen, Danielle Louise Nørager; Skovgaard, Thomas; Møller, Niels Christian

    condensed into a total amount of 63 factors, arranged into nine overall categories, and prioritized by the national expert group in the questionnaire (1.School leadership, 2.Co-workers, 3.Resources, 4.Policy level, 5.Organizational/cultural level, 6.Pupils, 7.Physical surroundings, 8.Intervention context......, and 9.External factors). Based on five expert interviews, outliers from the questionnaire was examined. Finally, at the workshop, five of the nine overall categories were rated as particularly relevant and important (School leadership, Co-workers, Policy level, Resources and Organizational/cultural...... level). Conclusions All nine overall categories are deemed as decisive for sustainable implementation of school-based PA. However, School leadership were singled out as a particular important category, since commitment at this level is deemed a pre-requisite for many of the other factors....

  5. ORNL Annual Sustainability Report

    Energy Technology Data Exchange (ETDEWEB)

    Lapsa, Melissa Voss [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Nichols, Teresa A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-02-01

    As described in this report, we have made substantial progress across the 25 roadmaps of the Sustainable Campus Initiative. The report also outlines our plans to continue integrating sustainable practices into the planning, execution, and evaluation of all ORNL activities. We appreciate your interest in our journey to sustainability, and we welcome your comments, questions, and suggestions.

  6. The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

    Science.gov (United States)

    Espinosa, Lluis; Cathelin, Severine; D'Altri, Teresa; Trimarchi, Thomas; Statnikov, Alexander; Guiu, Jordi; Rodilla, Veronica; Inglés-Esteve, Julia; Nomdedeu, Josep; Bellosillo, Beatriz; Besses, Carles; Abdel-Wahab, Omar; Kucine, Nicole; Sun, Shao-Cong; Song, Guangchan; Mullighan, Charles C; Levine, Ross L; Rajewsky, Klaus; Aifantis, Iannis; Bigas, Anna

    2010-09-14

    It was previously shown that the NF-κB pathway is downstream of oncogenic Notch1 in T cell acute lymphoblastic leukemia (T-ALL). Here, we visualize Notch-induced NF-κB activation using both human T-ALL cell lines and animal models. We demonstrate that Hes1, a canonical Notch target and transcriptional repressor, is responsible for sustaining IKK activation in T-ALL. Hes1 exerts its effects by repressing the deubiquitinase CYLD, a negative IKK complex regulator. CYLD expression was found to be significantly suppressed in primary T-ALL. Finally, we demonstrate that IKK inhibition is a promising option for the targeted therapy of T-ALL as specific suppression of IKK expression and function affected both the survival of human T-ALL cells and the maintenance of the disease in vivo. Copyright © 2010 Elsevier Inc. All rights reserved.

  7. Do unfavourable alcohol, smoking, nutrition and physical activity predict sustained leisure time sedentary behaviour? A population-based cohort study.

    Science.gov (United States)

    Nooijen, Carla F J; Möller, Jette; Forsell, Yvonne; Ekblom, Maria; Galanti, Maria R; Engström, Karin

    2017-08-01

    Comparing lifestyle of people remaining sedentary during longer periods of their life with those favourably changing their behaviour can provide cues to optimize interventions targeting sedentary behaviour. The objective of this study was to determine lifestyle predictors of sustained leisure time sedentary behaviour and assess whether these predictors were dependent on gender, age, socioeconomic position and occupational sedentary behaviour. Data from a large longitudinal population-based cohort of adults (aged 18-97years) in Stockholm responding to public health surveys in 2010 and 2014 were analysed (n=49,133). Leisure time sedentary behaviour was defined as >3h per day of leisure sitting time e.g. watching TV, reading or using tablet. Individuals classified as sedentary at baseline (n=9562) were subsequently categorized as remaining sedentary (n=6357) or reduced sedentary behaviour (n=3205) at follow-up. Lifestyle predictors were unfavourable alcohol consumption, smoking, nutrition, and physical activity. Odds ratios (OR) and corresponding 95% Confidence Intervals (CI) were calculated, adjusting for potential confounders. Unfavourable alcohol consumption (OR=1.22, CI:1.11-1.34), unfavourable candy- or cake consumption (OR=1.15, CI:1.05-1.25), and unfavourable physical activity in different contexts were found to predict sustained sedentary behaviour, with negligible differences according to gender, age, socioeconomic position and occupational sedentary behaviour. People with unfavourable lifestyle profiles regarding alcohol, sweets, or physical activity are more likely to remain sedentary compared to sedentary persons with healthier lifestyle. The impact of combining interventions to reduce leisure time sedentary behaviour with reducing alcohol drinking, sweet consumption and increasing physical activity should be tested as a promising strategy for behavioural modification. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Activated T cells sustain myeloid-derived suppressor cell-mediated immune suppression

    Science.gov (United States)

    Damuzzo, Vera; Francescato, Samuela; Pozzuoli, Assunta; Berizzi, Antonio; Mocellin, Simone; Rossi, Carlo Riccardo; Bronte, Vincenzo; Mandruzzato, Susanna

    2016-01-01

    The expansion of myeloid derived suppressor cells (MDSCs), a suppressive population able to hamper the immune response against cancer, correlates with tumor progression and overall survival in several cancer types. We have previously shown that MDSCs can be induced in vitro from precursors present in the bone marrow and observed that these cells are able to actively proliferate in the presence of activated T cells, whose activation level is critical to drive the suppressive activity of MDSCs. Here we investigated at molecular level the mechanisms involved in the interplay between MDSCs and activated T cells. We found that activated T cells secrete IL-10 following interaction with MDSCs which, in turn, activates STAT3 phosphorylation on MDSCs then leading to B7-H1 expression. We also demonstrated that B7-H1+ MDSCs are responsible for immune suppression through a mechanism involving ARG-1 and IDO expression. Finally, we show that the expression of ligands B7-H1 and MHC class II both on in vitro-induced MDSCs and on MDSCs in the tumor microenvironment of cancer patients is paralleled by an increased expression of their respective receptors PD-1 and LAG-3 on T cells, two inhibitory molecules associated with T cell dysfunction. These findings highlight key molecules and interactions responsible for the extensive cross-talk between MDSCs and activated T cells that are at the basis of immune suppression. PMID:26700461

  9. A quality improvement project sustainably decreased time to onset of active physical therapy intervention in patients with acute lung injury.

    Science.gov (United States)

    Dinglas, Victor D; Parker, Ann M; Reddy, Dereddi Raja S; Colantuoni, Elizabeth; Zanni, Jennifer M; Turnbull, Alison E; Nelliot, Archana; Ciesla, Nancy; Needham, Dale M

    2014-10-01

    Rehabilitation started early during an intensive care unit (ICU) stay is associated with improved outcomes and is the basis for many quality improvement (QI) projects showing important changes in practice. However, little evidence exists regarding whether such changes are sustainable in real-world practice. To evaluate the sustained effect of a quality improvement project on the timing of initiation of active physical therapy intervention in patients with acute lung injury (ALI). This was a pre-post evaluation using prospectively collected data involving consecutive patients with ALI admitted pre-quality improvement (October 2004-April 2007, n = 120) versus post-quality improvement (July 2009-July 2012, n = 123) from a single medical ICU. The primary outcome was time to first active physical therapy intervention, defined as strengthening, mobility, or cycle ergometry exercises. Among ICU survivors, more patients in the post-quality improvement versus pre-quality improvement group received physical therapy in the ICU (89% vs. 24%, P quality improvement versus pre-quality improvement group, there was a shorter median (interquartile range) time to first physical therapy (4 [2, 6] vs. 11 d [6, 29], P quality improvement period was associated with shorter time to physical therapy (adjusted hazard ratio [95% confidence interval], 8.38 [4.98, 14.11], P quality improvement period. The following variables were independently associated with a longer time to physical therapy: higher Sequential Organ Failure Assessment score (0.93 [0.89, 0.97]), higher FiO2 (0.86 [0.75, 0.99] for each 10% increase), use of an opioid infusion (0.47 [0.25, 0.89]), and deep sedation (0.24 [0.12, 0.46]). In this single-site, pre-post analysis of patients with ALI, an early rehabilitation quality improvement project was independently associated with a substantial decrease in the time to initiation of active physical therapy intervention that was sustained over 5 years. Over the entire pre

  10. Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, Yi-Chao [Division of Regenerative Medicine, Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan (China); Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan (China); Kao, Chien-Yu [Division of Regenerative Medicine, Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan (China); Graduate Program of Biotechnology in Medicine, Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan (China); Chung, Yu-Fen; Lee, Don-Ching [Division of Regenerative Medicine, Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan (China); Liu, Jen-Wei [Division of Regenerative Medicine, Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan (China); Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan (China); Chiu, Ing-Ming, E-mail: ingming@nhri.org.tw [Division of Regenerative Medicine, Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli, Taiwan (China); Graduate Program of Biotechnology in Medicine, Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan (China); Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan (China)

    2016-06-10

    Fibroblast growth factor 1 (FGF1) binds and activates FGF receptors, thereby regulating cell proliferation and neurogenesis. Human FGF1 gene 1B promoter (−540 to +31)-driven SV40 T antigen has been shown to result in tumorigenesis in the brains of transgenic mice. FGF1B promoter (−540 to +31)-driven green fluorescent protein (F1BGFP) has also been used in isolating neural stem cells (NSCs) with self-renewal and multipotency from developing and adult mouse brains. In this study, we provide six lines of evidence to demonstrate that FGF1/FGFR signaling is implicated in the expression of Aurora A (AurA) and the activation of its kinase domain (Thr288 phosphorylation) in the maintenance of glioblastoma (GBM) cells and NSCs. First, treatment of FGF1 increases AurA expression in human GBM cell lines. Second, using fluorescence-activated cell sorting, we observed that F1BGFP reporter facilitates the isolation of F1BGFP(+) GBM cells with higher expression levels of FGFR and AurA. Third, both FGFR inhibitor (SU5402) and AurA inhibitor (VX680) could down-regulate F1BGFP-dependent AurA activity. Fourth, inhibition of AurA activity by two different AurA inhibitors (VX680 and valproic acid) not only reduced neurosphere formation but also induced neuronal differentiation of F1BGFP(+) GBM cells. Fifth, flow cytometric analyses demonstrated that F1BGFP(+) GBM cells possessed different NSC cell surface markers. Finally, inhibition of AurA by VX680 reduced the neurosphere formation of different types of NSCs. Our results show that activation of AurA kinase through FGF1/FGFR signaling axis sustains the stem cell characteristics of GBM cells. Implications: This study identified a novel mechanism for the malignancy of GBM, which could be a potential therapeutic target for GBM. - Highlights: • We report that FGF1 treatment can stimulate AurA kinase expression in human GBM cells. • FGF1/FGFR signaling is involved in the activation of AurA kinase. • FGF1 sustains the self

  11. Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells

    International Nuclear Information System (INIS)

    Hsu, Yi-Chao; Kao, Chien-Yu; Chung, Yu-Fen; Lee, Don-Ching; Liu, Jen-Wei; Chiu, Ing-Ming

    2016-01-01

    Fibroblast growth factor 1 (FGF1) binds and activates FGF receptors, thereby regulating cell proliferation and neurogenesis. Human FGF1 gene 1B promoter (−540 to +31)-driven SV40 T antigen has been shown to result in tumorigenesis in the brains of transgenic mice. FGF1B promoter (−540 to +31)-driven green fluorescent protein (F1BGFP) has also been used in isolating neural stem cells (NSCs) with self-renewal and multipotency from developing and adult mouse brains. In this study, we provide six lines of evidence to demonstrate that FGF1/FGFR signaling is implicated in the expression of Aurora A (AurA) and the activation of its kinase domain (Thr288 phosphorylation) in the maintenance of glioblastoma (GBM) cells and NSCs. First, treatment of FGF1 increases AurA expression in human GBM cell lines. Second, using fluorescence-activated cell sorting, we observed that F1BGFP reporter facilitates the isolation of F1BGFP(+) GBM cells with higher expression levels of FGFR and AurA. Third, both FGFR inhibitor (SU5402) and AurA inhibitor (VX680) could down-regulate F1BGFP-dependent AurA activity. Fourth, inhibition of AurA activity by two different AurA inhibitors (VX680 and valproic acid) not only reduced neurosphere formation but also induced neuronal differentiation of F1BGFP(+) GBM cells. Fifth, flow cytometric analyses demonstrated that F1BGFP(+) GBM cells possessed different NSC cell surface markers. Finally, inhibition of AurA by VX680 reduced the neurosphere formation of different types of NSCs. Our results show that activation of AurA kinase through FGF1/FGFR signaling axis sustains the stem cell characteristics of GBM cells. Implications: This study identified a novel mechanism for the malignancy of GBM, which could be a potential therapeutic target for GBM. - Highlights: • We report that FGF1 treatment can stimulate AurA kinase expression in human GBM cells. • FGF1/FGFR signaling is involved in the activation of AurA kinase. • FGF1 sustains the self

  12. Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Ren; Nelson, Celeste M.; Muschler, John L.; Veiseh, Mandana; Vonderhaar, Barbara K.; Bissell, Mina J.

    2009-06-03

    Epithelial cells, once dissociated and placed in two-dimensional (2D) cultures, rapidly lose tissue-specific functions. We showed previously that in addition to prolactin, signaling by laminin-111 was necessary to restore functional differentiation of mammary epithelia. Here, we elucidate two additional aspects of laminin-111 action. We show that in 2D cultures, the prolactin receptor is basolaterally localized and physically segregated from its apically placed ligand. Detachment of the cells exposes the receptor to ligation by prolactin leading to signal transducers and activators of transcription protein 5 (STAT5) activation, but only transiently and not sufficiently for induction of milk protein expression. We show that laminin-111 reorganizes mammary cells into polarized acini, allowing both the exposure of the prolactin receptor and sustained activation of STAT5. The use of constitutively active STAT5 constructs showed that the latter is necessary and sufficient for chromatin reorganization and {beta}-casein transcription. These results underscore the crucial role of continuous laminin signaling and polarized tissue architecture in maintenance of transcription factor activation, chromatin organization, and tissue-specific gene expression.

  13. For sustainable participation by civil society in Europe in the oversight of nuclear activities

    International Nuclear Information System (INIS)

    Delalonde, J.C.

    2010-01-01

    The Aarhus Convention on access to information, public participation in decision-making and access to justice in environmental matters, was signed in 1998 by the European Community and European countries including the 27 Member States of the European Union (EU). That same year, the Committee of the Regions adopted a resolution on nuclear safety and local and regional democracy. These two texts indicate strong political and legal recognition of access to information and participation in the nuclear field. Ten years later, it would seem to be important to observe how these principles are actually implemented. As of 2009, the ANCCLI and the European Commission opened an 18-month European dialogue on the practical application of the Aarhus Convention in the nuclear field. The principle of this approach, called ACN for Aarhus Convention and Nuclear, is to promote feedback about practical application of the Aarhus Convention in the nuclear field in the various European countries, and to share this feedback in order to identify both difficulties and good practices and to initiate progress jointly with the various stakeholders concerned (authorities, civil society, operators, experts, local authorities, etc.). It is also an opportunity to look at the conditions for sustainable participation by civil society in monitoring nuclear issues. (author)

  14. MONITORING OF TOURISM ACTIVITIES IN TARGU-JIU - WAY OF MAINTAINING REGIONAL SUSTAINABLE DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Enea Constanta

    2012-12-01

    Full Text Available Tourism is one of the external factors of influence on an area. To minimize adverse effects and to enhance positive ones may be adopted various policies. A basic approach already highlighted, referring to encourage community participation in the tourism sector. Most important ways to enhance economic benefits are strong links between tourism and other economic sectors, encourage employment of local labor, property ownership and management of tourism enterprises by the local and tourist expenditure growth mainly through the purchase of articles of local production [5]. Between tourism and the environment are closely linked. Impact tourism can have both positive and negative, depending on how it is planned, developed and managed. Have taken various measures to protect the environment, such as the development of appropriate systems for utilities and transport, proper use of land and application of principles and standards development, managing the flow of visitors and tourists access their control objectives. Negative impacts of tourism can be minimized through planning, development and proper management. Turism development should be monitored continuously, and if problems arise, they must be addressed to ensure sustainable development [6].

  15. Meristem Plant Cells as a Sustainable Source of Redox Actives for Skin Rejuvenation

    Science.gov (United States)

    Korkina, Liudmila G.; Mayer, Wolfgang; de Luca, Chiara

    2017-01-01

    Recently, aggressive advertisement claimed a “magic role” for plant stem cells in human skin rejuvenation. This review aims to shed light on the scientific background suggesting feasibility of using plant cells as a basis of anti-age cosmetics. When meristem cell cultures obtained from medicinal plants are exposed to appropriate elicitors/stressors (ultraviolet, ultrasound ultraviolet (UV), ultrasonic waves, microbial/insect metabolites, heavy metals, organic toxins, nutrient deprivation, etc.), a protective/adaptive response initiates the biosynthesis of secondary metabolites. Highly bioavailable and biocompatible to human cells, low-molecular weight plant secondary metabolites share structural/functional similarities with human non-protein regulatory hormones, neurotransmitters, pigments, polyamines, amino-/fatty acids. Their redox-regulated biosynthesis triggers in turn plant cell antioxidant and detoxification molecular mechanisms resembling human cell pathways. Easily isolated in relatively large quantities from contaminant-free cell cultures, plant metabolites target skin ageing mechanisms, above all redox imbalance. Perfect modulators of cutaneous oxidative state via direct/indirect antioxidant action, free radical scavenging, UV protection, and transition-metal chelation, they are ideal candidates to restore photochemical/redox/immune/metabolic barriers, gradually deteriorating in the ageing skin. The industrial production of plant meristem cell metabolites is toxicologically and ecologically sustainable for fully “biological” anti-age cosmetics. PMID:28498360

  16. Neuron to astrocyte communication via cannabinoid receptors is necessary for sustained epileptiform activity in rat hippocampus.

    Directory of Open Access Journals (Sweden)

    Guyllaume Coiret

    Full Text Available Astrocytes are integral functional components of synapses, regulating transmission and plasticity. They have also been implicated in the pathogenesis of epilepsy, although their precise roles have not been comprehensively characterized. Astrocytes integrate activity from neighboring synapses by responding to neuronally released neurotransmitters such as glutamate and ATP. Strong activation of astrocytes mediated by these neurotransmitters can promote seizure-like activity by initiating a positive feedback loop that induces excessive neuronal discharge. Recent work has demonstrated that astrocytes express cannabinoid 1 (CB1 receptors, which are sensitive to endocannabinoids released by nearby pyramidal cells. In this study, we tested whether this mechanism also contributes to epileptiform activity. In a model of 4-aminopyridine induced epileptic-like activity in hippocampal slice cultures, we show that pharmacological blockade of astrocyte CB1 receptors did not modify the initiation, but significantly reduced the maintenance of epileptiform discharge. When communication in astrocytic networks was disrupted by chelating astrocytic calcium, this CB1 receptor-mediated modulation of epileptiform activity was no longer observed. Thus, endocannabinoid signaling from neurons to astrocytes represents an additional significant factor in the maintenance of epileptiform activity in the hippocampus.

  17. Neuron to astrocyte communication via cannabinoid receptors is necessary for sustained epileptiform activity in rat hippocampus.

    Science.gov (United States)

    Coiret, Guyllaume; Ster, Jeanne; Grewe, Benjamin; Wendling, Fabrice; Helmchen, Fritjof; Gerber, Urs; Benquet, Pascal

    2012-01-01

    Astrocytes are integral functional components of synapses, regulating transmission and plasticity. They have also been implicated in the pathogenesis of epilepsy, although their precise roles have not been comprehensively characterized. Astrocytes integrate activity from neighboring synapses by responding to neuronally released neurotransmitters such as glutamate and ATP. Strong activation of astrocytes mediated by these neurotransmitters can promote seizure-like activity by initiating a positive feedback loop that induces excessive neuronal discharge. Recent work has demonstrated that astrocytes express cannabinoid 1 (CB1) receptors, which are sensitive to endocannabinoids released by nearby pyramidal cells. In this study, we tested whether this mechanism also contributes to epileptiform activity. In a model of 4-aminopyridine induced epileptic-like activity in hippocampal slice cultures, we show that pharmacological blockade of astrocyte CB1 receptors did not modify the initiation, but significantly reduced the maintenance of epileptiform discharge. When communication in astrocytic networks was disrupted by chelating astrocytic calcium, this CB1 receptor-mediated modulation of epileptiform activity was no longer observed. Thus, endocannabinoid signaling from neurons to astrocytes represents an additional significant factor in the maintenance of epileptiform activity in the hippocampus.

  18. ANDRA - National Radioactive Waste Management Agency. Annual sustainable development and activity report 2012. Management report and financial statements 2012

    International Nuclear Information System (INIS)

    2013-01-01

    Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and Sustainable Development Report, with the management and financial statements report, of the Andra for the year 2012

  19. ANDRA - National Radioactive Waste Management Agency. Annual sustainable development and activity report 2011. Management report and financial statements 2011

    International Nuclear Information System (INIS)

    2012-01-01

    Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and Sustainable Development Report, with the management and financial statements report, of the Andra for the year 2011

  20. The benefits of sustained leisure-time physical activity on job strain.

    Science.gov (United States)

    Yang, X; Telama, R; Hirvensalo, M; Hintsanen, M; Hintsa, T; Pulkki-Råback, L; Viikari, J S A

    2010-08-01

    The long-term effects of leisure-time physical activity (LTPA) on job strain have not been assessed in a large prospective population-based cohort study. To examine the relationship between the LTPA and the prevalence of job strain. The participants were 861 full-time employees (406 men and 455 women), aged 24-39 years in 2001, from the ongoing Cardiovascular Risk in Young Finns Study. LTPA was assessed using a self-report questionnaire in 1992 and in 2001. The participants were grouped into four categories according to tertiles of LTPA index at two time points: persistently active, increasingly active, decreasingly active and persistently inactive. Job strain was measured in 2001 by indicators of job demands and job control. Baseline LTPA was inversely associated with job strain (P leisure may help young adults to cope with job strain. A long-term benefit of LTPA may play a role in the development of mental well-being.

  1. Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

    Science.gov (United States)

    Liszewski, M. Kathryn; Kolev, Martin; Le Friec, Gaelle; Leung, Marilyn; Bertram, Paula G.; Fara, Antonella F.; Subias, Marta; Pickering, Matthew C.; Drouet, Christian; Meri, Seppo; Arstila, T. Petteri; Pekkarinen, Pirkka T.; Ma, Margaret; Cope, Andrew; Reinheckel, Thomas; Rodriguez de Cordoba, Santiago; Afzali, Behdad; Atkinson, John P.; Kemper, Claudia

    2013-01-01

    Summary Complement is viewed as a critical serum-operative component of innate immunity, with processing of its key component, C3, into activation fragments C3a and C3b confined to the extracellular space. We report here that C3 activation also occurred intracellularly. We found that the T cell-expressed protease cathepsin L (CTSL) processed C3 into biologically active C3a and C3b. Resting T cells contained stores of endosomal and lysosomal C3 and CTSL and substantial amounts of CTSL-generated C3a. While “tonic” intracellular C3a generation was required for homeostatic T cell survival, shuttling of this intracellular C3-activation-system to the cell surface upon T cell stimulation induced autocrine proinflammatory cytokine production. Furthermore, T cells from patients with autoimmune arthritis demonstrated hyperactive intracellular complement activation and interferon-γ production and CTSL inhibition corrected this deregulated phenotype. Importantly, intracellular C3a was observed in all examined cell populations, suggesting that intracellular complement activation might be of broad physiological significance. PMID:24315997

  2. Alkali-Activated Natural Pozzolan/Slag Binder for Sustainable Concrete

    Science.gov (United States)

    Najimi, Meysam

    This study aimed to fully replace Portland cement (PC) with environmentally friendly binders capable of improving longevity of concrete. The new binders consisted of different proportions of natural Pozzolan and slag which were alkaline-activated with various combinations of sodium hydroxide and sodium silicate. A step-by-step research program was designed to (1) develop alkali-activated natural Pozzolan/slag pastes with adequate fresh and strength properties, (2) produce alkali-activated natural Pozzolan/slag mortars to assess the effects of dominant variables on their plastic and hardened properties, and (3) finally produce and assess fresh, mechanical, dimensional, transport and durability properties of alkali-activated natural Pozzolan/slag concretes. The major variables included in this study were binder combination (natural Pozzolan/slag combinations of 70/30, 50/50 and 30/70), activator combination (sodium silicate/sodium hydroxide combinations of 20/80, 25/75 and 30/70), and sodium hydroxide concentration (1, 1.75 and 2.5M). The experimental program assessed performance of alkali-activated natural Pozzolan/slag mixtures including fresh properties (flow and setting times), unit weights (fresh, demolded and oven-dry), mechanical properties (compressive and tensile strengths, and modulus of elasticity), transport properties (absorption, rapid chloride penetration, and rapid chloride migration), durability (frost resistance, chloride induced corrosion, and resistance to sulfuric acid attack), and dimensional stability (drying shrinkage). This study also compared the performance of alkali-activated natural Pozzolan/slag concretes with that of an equivalent reference Portland cement concrete having a similar flow and strength characteristics. The results of this study revealed that it was doable to find optimum binder proportions, activator combinations and sodium hydroxide concentrations to achieve adequate plastic and hardened properties. Nearly for all studied

  3. Sustained Performance of a "Physicianless" System of Automated Prehospital STEMI Diagnosis and Catheterization Laboratory Activation.

    Science.gov (United States)

    Potter, Brian J; Matteau, Alexis; Mansour, Samer; Naim, Charbel; Riahi, Mounir; Essiambre, Richard; Montigny, Martine; Sareault, Isabelle; Gobeil, François

    2017-01-01

    Treatment times for primary percutaneous coronary intervention frequently exceed the recommended maximum delay. Automated "physicianless" systems of prehospital cardiac catheterization laboratory (CCL) activation show promise, but have been met with resistance over concerns regarding the potential for false positive and inappropriate activations (IAs). From 2010 to 2015, first responders performed electrocardiograms (ECGs) in the field for all patients with a complaint of chest pain or dyspnea. An automated machine diagnosis of "acute myocardial infarction" resulted in immediate CCL activation and direct transfer without transmission or human reinterpretation of the ECG prior to patient arrival. Any activation resulting from a nondiagnostic ECG (no ST-elevation) was deemed an IA, whereas activations resulting from ECG's compatible with ST-elevation myocardial infarction but without angiographic evidence of a coronary event were deemed false positive. In 2012, the referral algorithm was modified to exclude supraventricular tachycardia and left bundle branch block. There were 155 activations in the early cohort (2010-2012; prior to algorithm modification) and 313 in the late cohort (2012-2015). Algorithm modification resulted in a 42% relative decrease in the rate of IAs (12% vs 7%; P IA and false positive is at least on par with systems that ensure real-time human oversight. Copyright © 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

  4. Sustained Treatment with Insulin Detemir in Mice Alters Brain Activity and Locomotion.

    Directory of Open Access Journals (Sweden)

    Tina Sartorius

    Full Text Available Recent studies have identified unique brain effects of insulin detemir (Levemir®. Due to its pharmacologic properties, insulin detemir may reach higher concentrations in the brain than regular insulin. This might explain the observed increased brain stimulation after acute insulin detemir application but it remained unclear whether chronic insulin detemir treatment causes alterations in brain activity as a consequence of overstimulation.In mice, we examined insulin detemir's prolonged brain exposure by continuous subcutaneous (s.c. application using either micro-osmotic pumps or daily s.c. injections and performed continuous radiotelemetric electrocorticography and locomotion recordings.Acute intracerebroventricular injection of insulin detemir activated cortical and locomotor activity significantly more than regular insulin in equimolar doses (0.94 and 5.63 mU in total, suggesting an enhanced acute impact on brain networks. However, given continuously s.c., insulin detemir significantly reduced cortical activity (theta: 21.3±6.1% vs. 73.0±8.1%, P<0.001 and failed to maintain locomotion, while regular insulin resulted in an increase of both parameters.The data suggest that permanently-increased insulin detemir levels in the brain convert its hyperstimulatory effects and finally mediate impairments in brain activity and locomotion. This observation might be considered when human studies with insulin detemir are designed to target the brain in order to optimize treatment regimens.

  5. Curcumin Conjugated with PLGA Potentiates Sustainability, Anti-Proliferative Activity and Apoptosis in Human Colon Carcinoma Cells

    Science.gov (United States)

    Waghela, Bhargav N.; Sharma, Anupama; Dhumale, Suhashini; Pandey, Shashibahl M.; Pathak, Chandramani

    2015-01-01

    Curcumin, an ingredient of turmeric, exhibits a variety of biological activities such as anti-inflammatory, anti-atherosclerotic, anti-proliferative, anti-oxidant, anti-cancer and anti-metastatic. It is a highly pleiotropic molecule that inhibits cell proliferation and induces apoptosis in cancer cells. Despite its imperative biological activities, chemical instability, photo-instability and poor bioavailability limits its utilization as an effective therapeutic agent. Therefore, enhancing the bioavailability of curcumin may improve its therapeutic index for clinical setting. In the present study, we have conjugated curcumin with a biodegradable polymer Poly (D, L-lactic-co-glycolic acid) and evaluated its apoptotic potential in human colon carcinoma cells (HCT 116). The results show that curcumin-PLGA conjugate efficiently inhibits cell proliferation and cell survival in human colon carcinoma cells as compared to native curcumin. Additionally, curcumin conjugated with PLGA shows improved cellular uptake and exhibits controlled release at physiological pH as compared to native curcumin. The curcumin-PLGA conjugate efficiently activates the cascade of caspases and promotes intrinsic apoptotic signaling. Thus, the results suggest that conjugation potentiates the sustainability, anti-proliferative and apoptotic activity of curcumin. This approach could be a promising strategy to improve the therapeutic index of cancer therapy. PMID:25692854

  6. Structural and mechanistic analysis of engineered trichodiene synthase enzymes from Trichoderma harzianum: towards higher catalytic activities empowering sustainable agriculture.

    Science.gov (United States)

    Kumari, Indu; Chaudhary, Nitika; Sandhu, Padmani; Ahmed, Mushtaq; Akhter, Yusuf

    2016-06-01

    Trichoderma spp. are well-known bioagents for the plant growth promotion and pathogen suppression. The beneficial activities of the fungus Trichoderma spp. are attributed to their ability to produce and secrete certain secondary metabolites such as trichodermin that belongs to trichothecene family of molecules. The initial steps of trichodermin biosynthetic pathway in Trichoderma are similar to the trichothecenes from Fusarium sporotrichioides. Trichodiene synthase (TS) encoded by tri5 gene in Trichoderma catalyses the conversion of farnesyl pyrophosphate to trichodiene as reported earlier. In this study, we have carried out a comprehensive comparative sequence and structural analysis of the TS, which revealed the conserved residues involved in catalytic activity of the protein. In silico, modelled tertiary structure of TS protein showed stable structural behaviour during simulations. Two single-substitution mutants, i.e. D109E, D248Y and one double-substitution mutant (D109E and D248Y) of TS with potentially higher activities are screened out. The mutant proteins showed more stability than the wild type, an increased number of electrostatic interactions and better binding energies with the ligand, which further elucidates the amino acid residues involved in the reaction mechanism. These results will lead to devise strategies for higher TS activity to ultimately enhance the trichodermin production by Trichoderma spp. for its better exploitation in the sustainable agricultural practices.

  7. Grassland Sustainability

    Science.gov (United States)

    Deborah U. Potter; Paulette L. Ford

    2004-01-01

    In this chapter we discuss grassland sustainability in the Southwest, grassland management for sustainability, national and local criteria and indicators of sustainable grassland ecosystems, and monitoring for sustainability at various scales. Ecological sustainability is defined as: [T]he maintenance or restoration of the composition, structure, and processes of...

  8. Self-sustained firing activities of the cortical network with plastic rules in weak AC electrical fields

    International Nuclear Information System (INIS)

    Qin Ying-Mei; Wang Jiang; Men Cong; Zhao Jia; Wei Xi-Le; Deng Bin

    2012-01-01

    Both external and endogenous electrical fields widely exist in the environment of cortical neurons. The effects of a weak alternating current (AC) field on a neural network model with synaptic plasticity are studied. It is found that self-sustained rhythmic firing patterns, which are closely correlated with the cognitive functions, are significantly modified due to the self-organizing of the network in the weak AC field. The activities of the neural networks are affected by the synaptic connection strength, the external stimuli, and so on. In the presence of learning rules, the synaptic connections can be modulated by the external stimuli, which will further enhance the sensitivity of the network to the external signal. The properties of the external AC stimuli can serve as control parameters in modulating the evolution of the neural network. (interdisciplinary physics and related areas of science and technology)

  9. Artemisia: Active and Interactive Monitoring of the Forests in Protected Areas Aimed at the Sustainable Management of Nature

    Directory of Open Access Journals (Sweden)

    Clelia Cirillo

    2014-12-01

    Full Text Available To pursue the usage of forests resources in the processes of economic and social development it is determining that the principles of natural heritage protection join in a concept of progress, based on evolution and technological innovation; the realization of innovative investigation and representation tools turns out to be useful to ease the integration of forests’ resources in shared development processes aimed at enhancing the cooperation of local actors, and to ease the territory’s sustainable growth and the development of the natural heritage. The integrated management of the actions aimed at protecting and easing the ecologic and recreative functioning of forests, which are increasingly exposed to pressures caused by several catastrophic factors, requires the tuning of modelling and active monitoring systems of the forests based on social networks and volunteering for the processes of data updating.

  10. "Sustainability on Earth" Webquests: Do They Qualify as Problem-Based Learning Activities?

    Science.gov (United States)

    Leite, Laurinda; Dourado, Luís; Morgado, Sofia

    2015-01-01

    Information and communication technologies (ICT), namely the Internet, can play a valuable educational role in several school subjects, including science education. The same applies to problem-based learning (PBL), that is, a student-centered active learning methodology that can prepare students for lifelong learning. WebQuests (WQs) combine PBL…

  11. Overview of CSIR’s activities towards smart sustainable energy for rural communities

    CSIR Research Space (South Africa)

    Szewczuk, S

    2013-04-01

    Full Text Available , activities have included thermal efficiency of building design, solar water heating and the evaluation of photovoltaic installations. CSIR has developed and established electronic databases that provide information on South Africa’s eco-system and that can...

  12. Activity Sets in Multi-Organizational Ecologies : A Project-Level Perspective on Sustainable Energy Innovations

    NARCIS (Netherlands)

    Gerrit Willem Ziggers; Kristina Manser; Bas Hillebrand; Paul Driessen; Josée Bloemer

    2014-01-01

    Complex innovations involve multi-organizational ecologies consisting of a myriad of different actors. This study investigates how innovation activities can be interpreted in the context of multi-organizational ecologies. Taking a project-level perspective, this study proposes a typology of four

  13. Adventurous activities, embodiment and nature: spiritual, sensual and sustainable? Embodying environmental justice

    Directory of Open Access Journals (Sweden)

    Barbara Humberstone

    2013-09-01

    Full Text Available This paper examines research on adventurous physical activities in nature from the perspective of the sentient body. Drawing upon ethnographic and autoethnographic research, I examine what has been termed 'peak' happenings or 'flow' which many who practise adventurous activities claim to experience through their whole body when in the 'zone'. I consider the concept of 'edgework', voluntary risk-taking, and insightful mobile and social understanding of the relationships between body, emotions and the elements, where the adventurous activity is experienced and interpreted as oneness with nature or expressed as 'spiritual' not only in high but also low risk nature-based sport. I then consider if and in what ways these knowledges may bring about greater understanding and action in relation to social and environmental justice. I argue that adventurous activities/nature-based sport may provide processes and practices that are alternative or complementary to traditional sporting 'body techniques' or 'body pedagogics'. I suggest that modern embodied adventurous practices in nature challenge dominant narratives of body/mind separation and potentially provide a pedagogic process fostering kinetic empathy. Finally I draw attention to the paradox of (re-presenting sensorial experiences of sport in nature and ask for consideration on how we interconnect with the environment when we participate in adventureous nature-based sports.

  14. Delivering Sustainable Practice? A Case Study of the Scottish Active Schools Programme

    Science.gov (United States)

    Reid, Gavin

    2009-01-01

    Since 1999, concerns about Scotland's future health and economic performance have profoundly impacted on the new Scottish Executive. Research highlighting an obesity crisis facing young Scots has, together with the work of Scotland's Physical Activity Task Force and Physical Education Review Group, encouraged the education of all young Scots to be…

  15. Overview of approaches to sustain forest productivity during forest road development and timber harvesting activities

    Science.gov (United States)

    Charles R. Blinn; Rick Dahlamn; James A. Mattson; Michael A. Thompson

    1999-01-01

    Various approaches are available to minimize impacts on forest productivity during forest road building and timber harvesting activities. These approaches include a variety of practices and technologies. They include practices such as reducing road and trail development, using designated trails, and leaving slash at the stump on nutrient deficient sites. Technology...

  16. Recycling of Sustainable Co-Firing Fly Ashes as an Alkali Activator for GGBS in Blended Cements.

    Science.gov (United States)

    Wu, Yann-Hwang; Huang, Ran; Tsai, Chia-Jung; Lin, Wei-Ting

    2015-02-16

    This study investigates the feasibility of co-firing fly ashes from different boilers, circulating fluidized beds (CFB) or stokers as a sustainable material in alkali activators for ground granulated blast-furnace slag (GGBS). The mixture ratio of GGBS and co-firing fly ashes is 1:1 by weight. The results indicate that only CF fly ash of CFB boilers can effectively stimulate the potential characteristics of GGBS and provide strength as an alkali activator. CF fly ash consists of CaO₃ (48.5%), SiO₂ (21.1%), Al₂O₃ (13.8%), SO₃ (10.06%), Fe₂O₃ (2.25%) and others (4.29%). SA fly ash consists of Al₂O₃ (19.7%), SiO₂ (36.3%), Fe2O3 (28.4%) and others (15.6%). SB fly ash consists of Al₂O₃ (15%), SiO₂ (25.4%), Zn (20.6%), SO₃ (10.9%), Fe₂O₃ (8.78%) and others (19.32%). The mixtures of SA fly ash and SB fly ash with GGBS, respectively, were damaged in the compressive strength test during seven days of curing. However, the built up strength of the CF fly ash and GGBS mixture can only be maintained for 7-14 days, and the compressive strength achieves 70% of that of a controlled group (cement in hardening cement paste). The strength of blended CF fly ash and GGBS started to decrease after 28 days, and the phenomenon of ettrigite was investigated due to the high levels of sulfur content. The CaO content in sustainable co-firing fly ashes must be higher than a certain percentage in reacting GGBS to ensure the strength of blended cements.

  17. Light manipulation of mosquito behaviour: acute and sustained photic suppression of biting activity in the Anopheles gambiae malaria mosquito.

    Science.gov (United States)

    Sheppard, Aaron D; Rund, Samuel S C; George, Gary F; Clark, Erin; Acri, Dominic J; Duffield, Giles E

    2017-06-16

    Host-seeking behaviours in anopheline mosquitoes are time-of-day specific, with a greater propensity for nocturnal biting. We investigated how a short exposure to light presented during the night or late day can inhibit biting activity and modulate flight activity behaviour. Anopheles gambiae (s.s.), maintained on a 12:12 LD cycle, were exposed transiently to white light for 10-min at the onset of night and the proportion taking a blood meal in a human biting assay was recorded every 2 h over an 8-h duration. The pulse significantly reduced biting propensity in mosquitoes 2 h following administration, in some trials for 4 h, and with no differences detected after 6 h. Conversely, biting levels were significantly elevated when mosquitoes were exposed to a dark treatment during the late day, suggesting that light suppresses biting behaviour even during the late daytime. These data reveal a potent effect of a discrete light pulse on biting behaviour that is both immediate and sustained. We expanded this approach to develop a method to reduce biting propensity throughout the night by exposing mosquitoes to a series of 6- or 10-min pulses presented every 2 h. We reveal both an immediate suppressive effect of light during the exposure period and 2 h after the pulse. This response was found to be effective during most times of the night: however, differential responses that were time-of-day specific suggest an underlying circadian property of the mosquito physiology that results in an altered treatment efficacy. Finally, we examined the immediate and sustained effects of light on mosquito flight activity behaviour following exposure to a 30-min pulse, and observed activity suppression during early night, and elevated activity during the late night. As mosquitoes and malaria parasites are becoming increasingly resistant to insecticide and drug treatment respectively, there is a necessity for the development of innovative control strategies beyond insecticide

  18. Conceptualising sustainability assessment

    International Nuclear Information System (INIS)

    Pope, Jenny; Annandale, David; Morrison-Saunders, Angus

    2004-01-01

    Sustainability assessment is being increasingly viewed as an important tool to aid in the shift towards sustainability. However, this is a new and evolving concept and there remain very few examples of effective sustainability assessment processes implemented anywhere in the world. Sustainability assessment is often described as a process by which the implications of an initiative on sustainability are evaluated, where the initiative can be a proposed or existing policy, plan, programme, project, piece of legislation, or a current practice or activity. However, this generic definition covers a broad range of different processes, many of which have been described in the literature as 'sustainability assessment'. This article seeks to provide some clarification by reflecting on the different approaches described in the literature as being forms of sustainability assessment, and evaluating them in terms of their potential contributions to sustainability. Many of these are actually examples of 'integrated assessment', derived from environmental impact assessment (EIA) and strategic environmental assessment (SEA), but which have been extended to incorporate social and economic considerations as well as environmental ones, reflecting a 'triple bottom line' (TBL) approach to sustainability. These integrated assessment processes typically either seek to minimise 'unsustainability', or to achieve TBL objectives. Both aims may, or may not, result in sustainable practice. We present an alternative conception of sustainability assessment, with the more ambitious aim of seeking to determine whether or not an initiative is actually sustainable. We term such processes 'assessment for sustainability'. 'Assessment for sustainability' firstly requires that the concept of sustainability be well-defined. The article compares TBL approaches and principles-based approaches to developing such sustainability criteria, concluding that the latter are more appropriate, since they avoid many

  19. RTE - Activity and sustainable development report 2016 + Business report - Consolidated accounts

    International Nuclear Information System (INIS)

    2017-01-01

    This document gathers several reports. The first one is an activity report which proposes an overview of RTE activities by outlining the contribution to the improvement of territory, customer, and electric power system performance, the contribution to innovation in terms of energy and digital transition (for example, development of smart grids), and development perspectives in terms of use of open data, of development of partnerships, and of work organisation. The next report is a business report which gives and comments financial and legal information (discussion of various accounting aspects and elements), social information (employment, work organisation, social relationships, safety, health, life quality, training, equal opportunities), environmental information (general policy, circular economy, struggle against climate change and adaptation, protection and development of biodiversity), and societal information. The last part contains a table of consolidated accounts followed by a detailed discussion and comment of its content

  20. Assessing dark tourism as a sustainable economic activity for emerging destinations using a multi criteria approach

    OpenAIRE

    Seraphin, Hugues

    2017-01-01

    The tourism industry only started to be considered as an economic activity in 1911 (Scutariu, 2009). The reasons why people have been travelling and are still travelling to certain places are for sport and leisure; culture; Visiting Friends and Relatives; business; health; religion; education (Barrow, 2008). These different reasons contribute to the branding of some destinations by visitors and potential visitors. On that basis, it is legitimate to wonder whether being branded as a dark touri...

  1. The IAEA activities towards enhanced utilisation, sustainability and applications of research reactors

    International Nuclear Information System (INIS)

    Ridikas, D.; Mank, G.; Adelfang, P.; Alldred, K.; Bradley, E.E.; Goldman, I.N.; Khvan, A.; Peld, N.

    2010-01-01

    This paper will give a brief introduction to the programmatic structure of the Research Reactor (RR) related activities of the IAEA sub-programme 'Research Reactors', under which the project on 'Enhancement of utilization and applications of RRs' will be presented in more detail. Both recent achievements and future planed actions will be reported with the major emphasis on RR utilisation related issues, specific applications of RRs, networks and coalitions, and assistance to the Member States (MS) planning their 1st RR. (author)

  2. Influence of glutamate-evoked pain and sustained elevated muscle activity on blood oxygenation in the human masseter muscle.

    Science.gov (United States)

    Suzuki, Shunichi; Arima, Taro; Kitagawa, Yoshimasa; Svensson, Peter; Castrillon, Eduardo

    2017-12-01

    This study aimed to investigate the effect of glutamate-evoked masseter muscle pain on intramuscular oxygenation during rest and sustained elevated muscle activity (SEMA). Seventeen healthy individuals participated in two sessions in which they were injected with glutamate and saline in random order. Each session was divided into three, 10-min periods. During the first (period 1) and the last (period 3) 10-min periods, participants performed five intercalated 1-min bouts of masseter SEMA with 1-min periods of 'rest'. At onset of the second 10-min period, glutamate (0.5 ml, 1 M; Ajinomoto, Tokyo, Japan) or isotonic saline (0.5 ml; 0.9%) was injected into the masseter muscle and the participants kept the muscle relaxed in a resting position for 10 min (period 2). The hemodynamic characteristics of the masseter muscle were recorded simultaneously during the experiment by a laser blood-oxygenation monitor. The results demonstrated that glutamate injections caused significant levels of self-reported pain in the masseter muscle; however, this nociceptive input did not have robust effects on intramuscular oxygenation during rest or SEMA tasks. Interestingly, these findings suggest an uncoupling between acute nociceptive activity and hemodynamic parameters in both resting and low-level active jaw muscles. Further studies are needed to explore the pathophysiological significance of blood-flow changes for persistent jaw-muscle pain conditions. © 2017 Eur J Oral Sci.

  3. The impact of green logistic based on financial economic, social and environment activities on sustainable monetary expansion indicators of Oman

    Directory of Open Access Journals (Sweden)

    Faris Alshubiri

    2017-05-01

    Full Text Available Purpose: The purpose of this study is to examine green logistic activities by three axes (financial economic, social and environment activities and how these activities affect on sustainable monetary expansion indicators as an evidence of Sultanate of Oman. Design/methodology/approach: This study began by definition elements of logistic green and how evolution of this concept in recent years. This concept analyzed after survey of previous studies on green logistic. The independent variables of green logistic  are includes of three components of financial economic , social and environment and applies these components to clarify the impact on expansionary monetary policy indicators ( broad , narrow and reserve money as a important signals  in determining a country's economy. This study used data published in statistical annual report of central bank of Oman as representative of country economic of sultanate of Oman from the period 2008 to 2015.  Findings: The results found two variables of government support to electricity sector (GSE and subsidy on soft loans to private sector and housing (SSLPH based on environment activities are statistical significant 1% and 5%. Only one variable of transport and communication (TC in financial economic activates is statistical significant at 1% and 5% , but all variables community, social and personal (CSP , cultural and religious affairs (CRA and social security and welfare (SSW in social activities are statistical significant at 1% 5% and 10% , finally , also the multiple regression test run of all variables of green logistics activities and each monetary expansion indicators and found there are a statistical significant at 1% and 5%, .The study recommends that should be attention with financial economic activities as a quantitative standard contributes to build the green logistic by diagnosed the priorities and existing economic and financial system that contributes of  sustainable development system in

  4. Sustainable Effectiveness of Applying Trauma Team Activation in Managing Trauma Patients in the Emergency Department.

    Science.gov (United States)

    Wuthisuthimethawee, Prasit; Molloy, Michael S; Ciottone, Gregory R

    2015-09-01

    To determine long term effectiveness of trauma team activation criteria by measuring emergency department length of stay (EDLOS) and 28-day mortality. A 3-year retrospective cohort study conducted in adult trauma patients who met one of the trauma team activation criteria (shock, penetrating torso injury, post traumatic arrest, respiratory rate of less than 12 or more than 30, and pulse rate of more than 120). Specific demographic data, physiologic parameters, EDLOS, injury severity score (ISS), and 28-day mortality were prospectively recorded into the Trauma Registry database. Multiple logistic regression analysis was used to determine factors affecting mortality. The Institutional Review Board approval was obtained prior to undertaking the project. Two hundred eighty two patients with a mean age of35.1 years old were eligible. The median ISS was 25 (range, 13-30). The median EDLOS was 85 minutes (range, 50-135) and the 28-day mortality rate was 46.5%. The mean age was 31.7 years in the survival group and 38.7 years in the fatal group (p = 0.001). The median ISS was 17 in the survival group and 26 in the fatal group (p = 0.000) and the median EDLOS was 110 minutes in the survival group and 82 minutes in the fatal group (p = 0.034). When compared to data prior to the TTA application, the median time of EDLOS improvedsustainably from 184 to 85 minutes (p = 0.000) and the mortality rate decreased from 66.7% to 46.5% (p = 0.057). The parameters affecting patient mortality were older age, high ISS, and shorter EDLOS. Trauma team activation criteria significantly improved acute trauma care in the emergency department and decreased mortality.

  5. Sustained Na+/H+ exchanger activation promotes gliotransmitter release from reactive hippocampal astrocytes following oxygen-glucose deprivation.

    Directory of Open Access Journals (Sweden)

    Pelin Cengiz

    Full Text Available Hypoxia ischemia (HI-related brain injury is the major cause of long-term morbidity in neonates. One characteristic hallmark of neonatal HI is the development of reactive astrogliosis in the hippocampus. However, the impact of reactive astrogliosis in hippocampal damage after neonatal HI is not fully understood. In the current study, we investigated the role of Na(+/H(+ exchanger isoform 1 (NHE1 protein in mouse reactive hippocampal astrocyte function in an in vitro ischemia model (oxygen/glucose deprivation and reoxygenation, OGD/REOX. 2 h OGD significantly increased NHE1 protein expression and NHE1-mediated H(+ efflux in hippocampal astrocytes. NHE1 activity remained stimulated during 1-5 h REOX and returned to the basal level at 24 h REOX. NHE1 activation in hippocampal astrocytes resulted in intracellular Na(+ and Ca(2+ overload. The latter was mediated by reversal of Na(+/Ca(2+ exchange. Hippocampal astrocytes also exhibited a robust release of gliotransmitters (glutamate and pro-inflammatory cytokines IL-6 and TNFα during 1-24 h REOX. Interestingly, inhibition of NHE1 activity with its potent inhibitor HOE 642 not only reduced Na(+ overload but also gliotransmitter release from hippocampal astrocytes. The noncompetitive excitatory amino acid transporter inhibitor TBOA showed a similar effect on blocking the glutamate release. Taken together, we concluded that NHE1 plays an essential role in maintaining H(+ homeostasis in hippocampal astrocytes. Over-stimulation of NHE1 activity following in vitro ischemia disrupts Na(+ and Ca(2+ homeostasis, which reduces Na(+-dependent glutamate uptake and promotes release of glutamate and cytokines from reactive astrocytes. Therefore, blocking sustained NHE1 activation in reactive astrocytes may provide neuroprotection following HI.

  6. Effect of Powdered Activated Carbon to Reduce Fouling in Membrane Bioreactors: A Sustainable Solution. Case Study

    Directory of Open Access Journals (Sweden)

    Giuseppe Mancini

    2013-04-01

    Full Text Available Membrane Bio Reactors (MBRs are mainly used for industrial wastewaters applications where their costs can be more easily afforded. High costs are basically due to energy consumption and membrane cleaning or replacement. Membrane fouling is responsible for reducing treated water production and increasing maintenance as well as operation costs. According to previous researches, the addition of Powdered Activated Carbon (PAC in high dosages could reduce membrane fouling; but such concentrations are economically unsustainable for operative conditions. A MBR pilot plant, fed by mixed liquor of a full-scale activated sludge process from a municipal wastewater treatment plant, was operated dosing low PAC concentrations (0, 2, 5, 10 and 20 mg·L−1, respectively. Experiments were also carried out at two different temperatures corresponding to summer and winter conditions. Results indicated that PAC addition was effective at the low dosages (2 and 5 mg·L−1 by reducing the permeate flux loss (from 16 up to 27%, respectively while higher PAC concentrations turns out in a useless cost increase.

  7. Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.

    Science.gov (United States)

    Ganapathy, Uday; Marrero, Joeli; Calhoun, Susannah; Eoh, Hyungjin; de Carvalho, Luiz Pedro Sorio; Rhee, Kyu; Ehrt, Sabine

    2015-08-10

    The human pathogen Mycobacterium tuberculosis (Mtb) likely utilizes host fatty acids as a carbon source during infection. Gluconeogenesis is essential for the conversion of fatty acids into biomass. A rate-limiting step in gluconeogenesis is the conversion of fructose 1,6-bisphosphate to fructose 6-phosphate by a fructose bisphosphatase (FBPase). The Mtb genome contains only one annotated FBPase gene, glpX. Here we show that, unexpectedly, an Mtb mutant lacking GLPX grows on gluconeogenic carbon sources and has detectable FBPase activity. We demonstrate that the Mtb genome encodes an alternative FBPase (GPM2, Rv3214) that can maintain gluconeogenesis in the absence of GLPX. Consequently, deletion of both GLPX and GPM2 is required for disruption of gluconeogenesis and attenuation of Mtb in a mouse model of infection. Our work affirms a role for gluconeogenesis in Mtb virulence and reveals previously unidentified metabolic redundancy at the FBPase-catalysed reaction step of the pathway.

  8. Sustained release of doxorubicin from zeolite-magnetite nanocomposites prepared by mechanical activation

    International Nuclear Information System (INIS)

    Arruebo, Manuel; Fernandez-Pacheco, Rodrigo; Irusta, Silvia; Arbiol, Jordi; Ibarra, M Ricardo; SantamarIa, Jesus

    2006-01-01

    Nanocomposites consisting of magnetite and FAU zeolite with a high surface area and adsorption capacity have been prepared by mechanical activation using high-energy milling at room temperature. FTIR results, as well as HRTEM, EFTEM, and XPS measurements, show that the resulting magnetic nanoparticles are covered by a thin aluminosilicate coating. A saturation magnetization as high as 16 emu g -1 and 94.2 Oe of coercivity were observed for the obtained composites. The main advantages of this synthesis procedure are (i) simplicity of the preparation procedure (ii) prevention of agglomeration of the magnetite nanoparticles to a large extent, and (iii) absence of free magnetite outside the zeolitic matrix. In addition, in vitro experiments revealed that the nanoparticles prepared were able to store and release substantial amounts of doxorubicin. In view of these advantages, these magnetic nanoparticles can be considered as potential candidates for drug-delivery applications

  9. Losartan reduces the immediate and sustained increases in muscle sympathetic nerve activity after hyperacute intermittent hypoxia.

    Science.gov (United States)

    Jouett, Noah P; Moralez, Gilbert; Raven, Peter B; Smith, Michael L

    2017-04-01

    Obstructive sleep apnea (OSA) is characterized by intermittent hypoxemia, which produces elevations in sympathetic nerve activity (SNA) and associated hypertension in experimental models that persist beyond the initial exposure. We tested the hypotheses that angiotensin receptor blockade in humans using losartan attenuates the immediate and immediately persistent increases in 1 ) SNA discharge and 2 ) mean arterial pressure (MAP) after hyperacute intermittent hypoxia training (IHT) using a randomized, placebo-controlled, repeated-measures experimental design. We measured ECG and photoplethysmographic arterial pressure in nine healthy human subjects, while muscle SNA (MSNA) was recorded in seven subjects using microneurography. Subjects were exposed to a series of hypoxic apneas in which they inhaled two to three breaths of nitrogen, followed by a 20-s apnea and 40 s of room air breathing every minute for 20 min. Hyperacute IHT produced substantial and persistent elevations in MSNA burst frequency (baseline: 15.3 ± 1.8, IHT: 24 ± 1.5, post-IHT 20.0 ± 1.3 bursts/min, all P 0.70). This investigation confirms the role of angiotensin II type 1a receptors in the immediate and persistent sympathoexcitatory and pressor responses to IHT. NEW & NOTEWORTHY This study demonstrates for the first time in humans that losartan, an angiotensin receptor blocker (ARB), abrogates the acute and immediately persistent increases in muscle sympathetic nerve activity and arterial pressure in response to acute intermittent hypoxia. This investigation, along with others, provides important beginning translational evidence for using ARBs in treatment of the intermittent hypoxia observed in obstructive sleep apnea patients. Copyright © 2017 the American Physiological Society.

  10. Active slag filters-simple and sustainable phosphorus removal from wastewater using steel industry byproduct.

    Science.gov (United States)

    Pratt, C; Shilton, A

    2010-01-01

    Active filtration, where effluent is passed through a reactive substrate such as steel slag, offers a simple and cost-effective option for removing phosphorus (P) from effluent. This work summarises a series of studies that focused on the world's only full-scale active slag filter operated through to exhaustion. The filter achieved 75% P-removal during its first 5 years, reaching a retention capacity of 1.23 g P/kg slag but then its performance sharply declined. Scanning electron microscopy, X-ray diffraction, X-ray fluorescence, and chemical extractions revealed that P sequestration was primarily achieved via adsorption onto iron (Fe) oxyhydroxides on the slag's surface. It was concluded that batch equilibrium tests, whose use has been repeatedly proposed in the literature, cannot be used as an accurate predictor of filter adsorption capacity because Fe oxyhydroxides form via chemical weathering in the field, and laboratory tests don't account for this. Research into how chemical conditions affect slag's P retention capacity demonstrated that near-neutral pH and high redox are optimal for Fe oxyhydroxide stability and overall filter performance. However, as Fe oxyhydroxide sites fill up, removal capacity becomes exhausted. Attempts to regenerate P removal efficiency using physical techniques proved ineffective contrary to dogma in the literature. Based on the newly-developed understanding of the mechanisms of P removal, chemical regeneration techniques were investigated and were shown to strip large quantities of P from filter adsorption sites leading to a regenerated P removal efficiency. This raises the prospect of developing a breakthrough technology that can repeatedly remove and recover P from effluent.

  11. Sustainable Food & Sustainable Economics

    OpenAIRE

    Alvarez, Mavis Dora

    2012-01-01

    Cuba today is immersed in a very intense process of perfecting its agricultural production structures with the goal of making them more efficient and sustainable in their economic administration and in their social and environmental management. Agricultural cooperatives in Cuba have the responsibility of producing on 73% of the country's farmland. Their contributions are decisive to developing agricultural production and to ensuring more and better food for the population, in addition to redu...

  12. Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts.

    Science.gov (United States)

    Aflaki, Mona; Qi, Xiao-Yan; Xiao, Ling; Ordog, Balazs; Tadevosyan, Artavazd; Luo, Xiaobin; Maguy, Ange; Shi, Yanfen; Tardif, Jean-Claude; Nattel, Stanley

    2014-03-14

    β-Adrenoceptor activation contributes to sudden death risk in heart failure. Chronic β-adrenergic stimulation, as occurs in patients with heart failure, causes potentially arrhythmogenic reductions in slow delayed-rectifier K(+) current (IKs). To assess the molecular mechanisms of IKs downregulation caused by chronic β-adrenergic activation, particularly the role of exchange protein directly activated by cAMP (Epac). Isolated guinea pig left ventricular cardiomyocytes were incubated in primary culture and exposed to isoproterenol (1 μmol/L) or vehicle for 30 hours. Sustained isoproterenol exposure decreased IKs density (whole cell patch clamp) by 58% (P<0.0001), with corresponding decreases in potassium voltage-gated channel subfamily E member 1 (KCNE1) mRNA and membrane protein expression (by 45% and 51%, respectively). Potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) mRNA expression was unchanged. The β1-adrenoceptor antagonist 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol dihydrochloride (CGP-20712A) prevented isoproterenol-induced IKs downregulation, whereas the β2-antagonist ICI-118551 had no effect. The selective Epac activator 8-pCPT-2'-O-Me-cAMP decreased IKs density to an extent similar to isoproterenol exposure, and adenoviral-mediated knockdown of Epac1 prevented isoproterenol-induced IKs/KCNE1 downregulation. In contrast, protein kinase A inhibition with a cell-permeable highly selective peptide blocker did not affect IKs downregulation. 1,2-Bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetate-AM acetoxymethyl ester (BAPTA-AM), cyclosporine, and inhibitor of nuclear factor of activated T cell (NFAT)-calcineurin association-6 (INCA6) prevented IKs reduction by isoproterenol and INCA6 suppressed isoproterenol-induced KCNE1 downregulation, consistent with signal-transduction via the Ca(2+)/calcineurin/NFAT pathway. Isoproterenol induced nuclear NFATc3/c4

  13. IAEA activities on education and training in radiation and waste safety: Strategic approach for a sustainable system

    International Nuclear Information System (INIS)

    Mrabit, Khammar; Sadagopan; Geetha

    2003-01-01

    The statutory safety functions of the International Atomic Energy Agency (IAEA) include the establishment of and provision for the application of safety standards for protection of health, life and property against ionizing radiation. The safety standards are based on the presumption that a national infrastructure is in place enabling the Government to discharge its responsibilities for protection and safety. Education and training is an essential element of the infrastructure. The IAEA education and training activities follows the resolutions of its General Conferences and reflects the latest IAEA standards and guidance. In response to GC(44)/RES/13, the IAEA prepared a 'Strategic Approach to Education and Training in Radiation and Waste Safety' aiming at establishing, by 2010, sustainable education a training programmes in Member States. This Strategy was endorsed by General Conference resolution GC(45)/RES/10C that, inter alia, urged the Secretariat to implement the Strategy on Education and Training and to continue to strengthen, subject to available resources, its current effort in this area, and in particular to assist Member States' national, regional and collaborating centres in conducting such education and training activities in the relevant official languages of the IAEA. In the last General Conference 2002, the IAEA was urged to continue to implement the Strategy, including the convening of the Steering Committee. The first Technical Committee meeting took place during the week 25-29 November 2002. (author)

  14. Activating Patients for Sustained Chronic Disease Self-Management: Thinking Beyond Clinical Outcomes.

    Science.gov (United States)

    Dye, Cheryl J; Williams, Joel E; Evatt, Janet H

    2016-04-01

    This article describes the impact of an 8-week community program implemented by trained volunteers on the hypertension self-management of 185 patients who were batch randomized to intervention or wait-list control groups. Compared with control group participants, a higher proportion of treatment group participants moved from the cognitive to behavioral stages of motivational readiness for being physically active (P healthy eating habits (P = .001), handling stress well (P = .001), and living an overall healthy lifestyle (P = .003). They also demonstrated a greater average increase in perceived competence for self-management, F(1.134) = 4.957, P = .028, η2 = .036, and a greater increase in mean hypertension-related knowledge, F(1.160) = 16.571, P < .0005, η(2) = .094. Enduring lifestyle changes necessary for chronic disease self-management require that psychosocial determinants of health behavior are instilled, which is typically beyond standard medical practice. We recommend peer-led, community-based programs as a complement to clinical care and support the increasing health system interest in promoting population health beyond clinical walls. © The Author(s) 2016.

  15. RTE - 2013 Activity Report, 2013 Activity and Sustainable Development Report, financial results for 2013, Report of the Chairman of the Supervisory Board

    International Nuclear Information System (INIS)

    2014-01-01

    RTE is the operator of the high and extra high-voltage transmission system in France. RTE operates, develops and maintains it. This role places RTE at the heart of smart power, supplying its customers: generators, distribution system operators, industrial customers and traders. RTE deploys its expertise to achieve smart power, with three objectives: - To optimise the power system so that everything operates at the lowest cost, every second, whatever the weather brings, whatever the level of supply and demand. - To guarantee a secure power supply, by offering tools and mechanisms that can be used to adjust generation and power consumption. - To adapt the grid to energy transition through constant innovation. RTE counts 8,400 employees. This document gathers both French and English versions of the 2013 Activity and Sustainable Development Report and the English version of the 2013 financial results and of the Report of the Chairman of the Supervisory Board

  16. Distributed patterns of activity in sensory cortex reflect the precision of multiple items maintained in visual short-term memory.

    Science.gov (United States)

    Emrich, Stephen M; Riggall, Adam C; Larocque, Joshua J; Postle, Bradley R

    2013-04-10

    Traditionally, load sensitivity of sustained, elevated activity has been taken as an index of storage for a limited number of items in visual short-term memory (VSTM). Recently, studies have demonstrated that the contents of a single item held in VSTM can be decoded from early visual cortex, despite the fact that these areas do not exhibit elevated, sustained activity. It is unknown, however, whether the patterns of neural activity decoded from sensory cortex change as a function of load, as one would expect from a region storing multiple representations. Here, we use multivoxel pattern analysis to examine the neural representations of VSTM in humans across multiple memory loads. In an important extension of previous findings, our results demonstrate that the contents of VSTM can be decoded from areas that exhibit a transient response to visual stimuli, but not from regions that exhibit elevated, sustained load-sensitive delay-period activity. Moreover, the neural information present in these transiently activated areas decreases significantly with increasing load, indicating load sensitivity of the patterns of activity that support VSTM maintenance. Importantly, the decrease in classification performance as a function of load is correlated with within-subject changes in mnemonic resolution. These findings indicate that distributed patterns of neural activity in putatively sensory visual cortex support the representation and precision of information in VSTM.

  17. Engineering online and in-person social networks to sustain physical activity: application of a conceptual model.

    Science.gov (United States)

    Rovniak, Liza S; Sallis, James F; Kraschnewski, Jennifer L; Sciamanna, Christopher N; Kiser, Elizabeth J; Ray, Chester A; Chinchilli, Vernon M; Ding, Ding; Matthews, Stephen A; Bopp, Melissa; George, Daniel R; Hovell, Melbourne F

    2013-08-14

    High rates of physical inactivity compromise the health status of populations globally. Social networks have been shown to influence physical activity (PA), but little is known about how best to engineer social networks to sustain PA. To improve procedures for building networks that shape PA as a normative behavior, there is a need for more specific hypotheses about how social variables influence PA. There is also a need to integrate concepts from network science with ecological concepts that often guide the design of in-person and electronically-mediated interventions. Therefore, this paper: (1) proposes a conceptual model that integrates principles from network science and ecology across in-person and electronically-mediated intervention modes; and (2) illustrates the application of this model to the design and evaluation of a social network intervention for PA. A conceptual model for engineering social networks was developed based on a scoping literature review of modifiable social influences on PA. The model guided the design of a cluster randomized controlled trial in which 308 sedentary adults were randomly assigned to three groups: WalkLink+: prompted and provided feedback on participants' online and in-person social-network interactions to expand networks for PA, plus provided evidence-based online walking program and weekly walking tips; WalkLink: evidence-based online walking program and weekly tips only; Minimal Treatment Control: weekly tips only. The effects of these treatment conditions were assessed at baseline, post-program, and 6-month follow-up. The primary outcome was accelerometer-measured PA. Secondary outcomes included objectively-measured aerobic fitness, body mass index, waist circumference, blood pressure, and neighborhood walkability; and self-reported measures of the physical environment, social network environment, and social network interactions. The differential effects of the three treatment conditions on primary and secondary

  18. Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes.

    Science.gov (United States)

    Sun, Shishuo; Tan, Pengcheng; Huang, Xiaoheng; Zhang, Wei; Kong, Chen; Ren, Fangfang; Su, Xiong

    2018-02-16

    Both the magnitude and duration of insulin signaling are important in executing its cellular functions. Insulin-induced degradation of insulin receptor substrate 1 (IRS1) represents a key negative feedback loop that restricts insulin signaling. Moreover, high concentrations of fatty acids (FAs) and glucose involved in the etiology of obesity-associated insulin resistance also contribute to the regulation of IRS1 degradation. The scavenger receptor CD36 binds many lipid ligands, and its contribution to insulin resistance has been extensively studied, but the exact regulation of insulin sensitivity by CD36 is highly controversial. Herein, we found that CD36 knockdown in C2C12 myotubes accelerated insulin-stimulated Akt activation, but the activated signaling was sustained for a much shorter period of time as compared with WT cells, leading to exacerbated insulin-induced insulin resistance. This was likely due to enhanced insulin-induced IRS1 degradation after CD36 knockdown. Overexpression of WT CD36, but not a ubiquitination-defective CD36 mutant, delayed IRS1 degradation. We also found that CD36 functioned through ubiquitination-dependent binding to IRS1 and inhibiting its interaction with cullin 7, a key component of the multisubunit cullin-RING E3 ubiquitin ligase complex. Moreover, dissociation of the Src family kinase Fyn from CD36 by free FAs or Fyn knockdown/inhibition accelerated insulin-induced IRS1 degradation, likely due to disrupted IRS1 interaction with CD36 and thus enhanced binding to cullin 7. In summary, we identified a CD36-dependent FA-sensing pathway that plays an important role in negative feedback regulation of insulin activation and may open up strategies for preventing or managing type 2 diabetes mellitus. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  19. Sustainability of the Catalytic Activity of a Silica-Titania Composite (STC) for Long-Term Indoor Air Quality Control

    Science.gov (United States)

    Coutts, Janelle L.; Levine, Lanfang H.; Richards, Jeffrey T.

    2011-01-01

    TiO2-assisted photocatalytic oxidation (PCO) is an emerging technology for indoor air quality control and is also being evaluated as an alternative trace contaminant control technology for crew habitats in space exploration. Though there exists a vast range of literature on the development of photocatalysts and associated reactor systems, including catalyst performance and performance-influencing factors, the critical question of whether photocatalysts can sustain their initial catalytic activity over an extended period of operation has not been adequately addressed. For a catalyst to effectively serve as an air quality control product, it must be rugged enough to withstand exposure to a multitude of low concentration volatile organic compounds (VOCs) over long periods of time with minimal loss of activity. The objective of this study was to determine the functional lifetime of a promising photocatalyst - the silica-titania composite (STC) from Sol Gel Solutions, LLC in a real-world scenario. A bench-scale STC-packed annular reactor under continuous irradiation by a UV-A fluorescent black-light blue lamp ((lambda)max = 365 nm) was exposed to laboratory air continuously at an apparent contact time of 0.27 sand challenged with a known concentration of ethanol periodically to assess any changes in catalytic activity. Laboratory air was also episodically spiked with halocarbons (e.g., octafluoropropane), organosulfur compounds (e.g., sulfur hexafluoride), and organosilicons (e.g., siloxanes) to simulate accidental releases or leaks of such VOCs. Total organic carbon (TOC) loading and contaminant profiles of the laboratory air were also monitored. Changes in STC photocatalytic performance were evaluated using the ethanol mineralization rate, mineralization efficiency, and oxidation intermediate (acetaldehyde) formation. Results provide insights to any potential catalyst poisoning by trace halocarbons and organosulfur compounds.

  20. Sustainability and Organizational Change

    OpenAIRE

    Sitnikov, Catălina

    2012-01-01

    The relevant and, above all, remarkable feature of sustainability is due to its "duality": on the one hand, it is an indispensable element within the companies even if, on the other hand, it increases the costs of many activities and processes. Facing the challenge of sustainability will determine and create, in the coming years, emerging organizational forms. If ten years ago, many managers clearly expressed their doubts regarding the financial feasibility of sustainability, today, they admi...

  1. Kazan period of life-sustaining activity of professor V.I. Ra-zumovsky — a pioneer of Russian neurosurgery

    Directory of Open Access Journals (Sweden)

    Danilov V.I.

    2012-06-01

    Full Text Available There were presented historical data of life-sustaining activity of professor V. I. Razumovsky — a pioneer of Russian neurosurgery, who began to perform and then was performing systematically neurosurgical operations in the Kazan clinic under the guidance of outstanding neurologists V. M. Bekhterev and L. O. Darkshevich.

  2. The Reality of Sustaining Community-Based Sport and Physical Activity Programs to Enhance the Development of Underserved Youth: Challenges and Potential Strategies

    Science.gov (United States)

    Whitley, Meredith A.; Forneris, Tanya; Barker, Bryce

    2015-01-01

    Many community-based sport and physical activity programs take a positive youth development approach when operating in underserved communities around the world (Forneris, Whitley, & Barker, 2013). However, one of the biggest challenges for these programs is sustainability (Lindsey, 2008). The purpose of this article is to present the 3…

  3. Sustainability; Sustentabilidade

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-10-15

    This chapter analyses the production chain of ethanol, considering the impacts on the quality of the air, water supplies, soil occupation and biodiversity, and the efforts for the soil preservation. It is pointed out the activities of the production cycle and use of bio ethanol due to great uncertainties as far the environmental impacts is concerning and that will deserve more attention in future evaluations. At same time, the chapter highlights another activities where the present acknowledge is sufficient to assure the control and/or prediction of consequences of the desired intervention on the environment media to accommodate the sugar and ethanol production expansion. The consideration is not conservative but to promote the sustainable development.

  4. Interactive activities to stimulate debate and critical thinking about issues related to Earth sciences and sustainable development

    Directory of Open Access Journals (Sweden)

    Alessandra Magagna

    2012-07-01

    Full Text Available During the International Year of Planet Earth (2007-2009, the Department of Earth Sciences of Turin University and a local Museum of Natural History promoted a project entitled, Understanding how the Earth works: from local situations to global processes. In this context, two geothematic exhibitions on the Cape Verde Archipelago were designed and staged in local museums. The exhibition called Getting to know a volcano in order to live with it was the subject of action research that involved the design of interactive activities and the analysis of data collected during guided tours conducted with students of different ages. This study allowed the demonstration of the effectiveness of teaching strategies in which relevant Earth sciences topics are proposed, like risk and sustainable development, thus stimulating debate among the students. This approach enhances the cultural experience of individuals by sharing it with other people. The aim was to widen their awareness of the cultural value of the territory, and to stimulate a new critical way of thinking about the Earth sciences. These didactic tools were further developed when they were proposed and pursued by experienced museum guides and teachers, who were able to involve not only institutions (museums and schools in the knowledge construction process, but also families, relatives and the local community.

  5. A Study on the Relationship between Design Elements of Outdoor Leisure Spaces and Types of Leisure Activities in Sustainable Community Development - A Case Study on Tainan, Taiwan

    Science.gov (United States)

    Chang, J. H.; Zhang, H.

    2018-01-01

    Sustainable community development encompasses three aspects: “Lifestyle”, “Production” and “Ecology”. Among them, “Lifestyle” is closest to people and reflects basic human needs. Creating outdoor spaces that encourage residents to engage in leisure activities will not only provide them with spiritual sustenance but also fulfil one of the key criteria in sustainable community development. This study explores the relationship between design elements of outdoor leisure spaces and types of leisure activities from residents' perspective with the goal to inform future spatial planning. The study collected 365 valid questionnaires from Tainan residents. Factor analysis was used to extract factors from design elements of outdoor leisure spaces, and regression analysis was applied to understand the effect level. The result shows design elements have positive effect on the types of leisure activities. In addition, different elements exert different influences on the choice of activities.

  6. Upscaling Self-Sustaining Treatment for Active Remediation (STAR): Experimental Study of Scaling Relationships for Smouldering Combustion to Remediate Soil

    Science.gov (United States)

    Kinsman, L.; Gerhard, J.; Torero, J.; Scholes, G.; Murray, C.

    2013-12-01

    Self-sustaining Treatment for Active Remediation (STAR) is a relatively new remediation approach for soil contaminated with organic industrial liquids. This technology uses smouldering combustion, a controlled, self-sustaining burning reaction, to destroy nonaqueous phase liquids (NAPLs) and thereby render soil clean. While STAR has been proven at the bench scale, success at industrial scales requires the process to be scaled-up significantly. The objective of this study was to conduct an experimental investigation into how liquid smouldering combustion phenomena scale. A suite of detailed forward smouldering experiments were conducted in short (16 cm dia. x 22 cm high), intermediate (16 cm dia. x 127 cm high), and large (97 cm dia. x 300 cm high; a prototype ex-situ reactor) columns; this represents scaling of up to 530 times based on the volume treated. A range of fuels were investigated, with the majority of experiments conducted using crude oil sludge as well as canola oil as a non-toxic surrogate for hazardous contaminants. To provide directly comparable data sets and to isolate changes in the smouldering reaction which occurred solely due to scaling effects, sand grain size, contaminant type, contaminant concentration and air injection rates were controlled between the experimental scales. Several processes could not be controlled and were identified to be susceptible to changes in scale, including: mobility of the contaminant, heat losses, and buoyant flow effects. For each experiment, the propagation of the smouldering front was recorded using thermocouples and analyzed by way of temperature-time and temperature-distance plots. In combination with the measurement of continuous mass loss and gaseous emissions, these results were used to evaluate the fundamental differences in the way the reaction front propagates through the mixture of sand and fuel across the various scales. Key governing parameters were compared between the small, intermediate, and large

  7. IAEA Activities on Education and training in Radiation and Waste Safety: Strategic approach for a sustainable system

    International Nuclear Information System (INIS)

    Marabit, K.; Sadagopan, G.

    2003-01-01

    The statutory safety functions of the International Atomic Energy(IAEA) include the establishment of and provision for the application of safety standards for protection of health, life and property against ionizing radiation. The safety standards are based on the presumption that a national infrastructure is in place, enabling the Government to discharge its responsibilities for protection and safety. Education and training is an essential element of the infrastructure. the IAEA education and training activities follow the resolutions of its General Conference and reflect the latest IAEA standards and guidance. Several General Conference resolutions have emphasized the importance of education and training (e. g. GC(XXXV)/RES/552 in 1991; GC(XXXVI)/RES/584 in 1992; GC(43)/RES/13 in 1999 and more recently GC(44)/RES/13 in 2000). In response to GC(44)/RES/13, the IAEA prepared a Strategic Approach to Education and Training in Radiation and Waste Safety (Strategy on Education and Training) aiming at establishing, by 2010, sustainable education and training programmes in its Member States. This Strategy was endorsed by the General Conference resolution GC(45)/RES/10C that, inter alia, urged the Secretariat to implement the Strategy on Education and Training, and to continue to strengthen, subject to available resources, its current effort in this area, and in particular to assist Member States national, regional and collaborating centres in conducting such education and training activities in the relevant official languages of the IAEA. A technical meeting was held in Vienna in March 2002 and concluded with an action plan for implementing the strategy up to 2010, the immediate action being the formation of a Steering Committee by the middle of 2002. This Steering Committee has the general remit to advise on the development and implementation of the strategy, as well as monitoring its progress. The first technical meeting of the Steering Committee took place on 25

  8. The combined use of Pochonia chlamydosporia and plant defence activators - a potential sustainable control strategy for Meloidogyne chitwoodi

    Directory of Open Access Journals (Sweden)

    Maria Clara VIEIRA DOS SANTOS

    2014-05-01

    Full Text Available Sustainable strategies are required for control of the root-knot nematode Meloidogyne chitwoodi to reduce dependence on toxic chemical pesticides. The efficacy of the nematophagous fungus Pochonia chlamydosporia in biocontrol could be enhanced by integration with control measures that reduce initial nematode infestations. The use of foliar sprays with plant defence activators can reduce the susceptibility of potato plants to M. chitwoodi. This study assessed effects of combined soil application of P. chlamydosporia with foliar sprays of benzothiadiazole (BTH or cis-jasmone on infection of potatoes by M. chitwoodi. Solanum tuberosum, cv. Désirée plants were grown in soil mixed with 5000 chlamydospores g-1 of soil, sprayed twice with BTH or cis-jasmone and inoculated with 300 M. chitwoodi second-stage juveniles. Forty-five days after inoculation, nematode reproduction, numbers of colony-forming units of the fungus g-1 of soil and g-1 of root, and egg parasitism were assessed by standard techniques. Foliar sprays of BTH or cis-jasmone combined with the fungus reduced nematode reproduction (P<0.05, LSD. The presence of the fungus slightly increased the efficacy of cis-jasmone, as the number of eggs per egg mass was less in plants treated both with cis-jasmone and the fungus than in the plants treated only with the defence activator. The proportion of parasitized eggs was greater in the cis-jasmone treatment where rhizosphere colonisation was less, suggesting that P. chlamydosporia became a poorer rhizosphere coloniser but a more efficient nematode parasite. The addition of P. chlamydosporia to soil in combination with application of inducers of plant defence could be an alternative control strategy to be used against M. chitwoodi in potato.

  9. Measurement in Sustainable Building

    DEFF Research Database (Denmark)

    Hale, Lara

    2018-01-01

    Measurement is a necessary aspect of planning and constructing buildings. However, recent attempts to integrate the social dimension of sustainable building into building design and specifications demand measurement of non-technical qualities, such as well-being. The Active House Alliance, in lieu...... and continued provision of sustainable buildings to market demand....

  10. Motor function and activities of daily living capacity of patients with fractures sustained during the Wenchuan earthquake.

    Science.gov (United States)

    Zhang, Jin-Long; He, Hong-Chen; Lin, Hai-Dan; Luo, Qing-Lu; Xia, Lu; Li, Sha-Sha; He, Cheng-Qi

    2011-05-01

    On the afternoon of May 12, 2008, a 8.0-magnitude earthquake hit Sichuan Province, a mountainous region in Western China, killing about 70 000 people and leaving over 18 000 missing. What about the survivors motor functions and activities of daily living (ADL) capacity, especially for fractures? We need the data to guide the rehabilitation for the seismic wounded and it's important to collect the data for the future. We study the survivors to understand the motor functions and ADL capacity of patients with fractures sustained in the Wenchuan earthquake, to provide a basis for rehabilitation and treatment. We used the Manual Muscle Testing method to evaluate muscle strength, the joint angle scale to measure joint range of motion (ROM), and the Barthel index to evaluate the activities of daily living status. SPSS 13.0 software was used to analyze the data and the results were tested using one-way analysis of variance (ANOVA). The number of seismic wounded amounted to 487; 81.1% of patients had fractures. Most of the injured had fractures in multiple regions (53.9% of all fracture patients), followed by fractures of the upper limb (34.0% of patients); cranial fractures were rare (2.3%). Totally 82.0% had restricted range of motion, 23.5% had decreased muscle force, and 72.2% of the patients had restricted activities of daily living capacities. With time the activities of daily living capacity of female increased (P 0.05). The difference between the patients' ages and ADL capacities did not reach statistical significance (P > 0.05), nor was there a significant difference between their ages and the numbers of days in hospital (P > 0.05). Fractures were the main issue in the seismic wounded, many of them had reductions in the ROM, muscle force and ADL capacities. The physicians involved in rehabilitation should pay greater attention to muscle force exercises, joint mobilization, and occupational therapy during the early phases post disaster.

  11. Why Did Zika Not Explode in Cuba? The Role of Active Community Participation to Sustain Control of Vector-Borne Diseases.

    Science.gov (United States)

    Castro, Marta; Pérez, Dennis; Guzman, Maria G; Barrington, Clare

    2017-08-01

    As the global public health community develops strategies for sustainable Zika prevention and control, assessment of the Cuban response to Zika provides critical lessons learned. Cuba's early and successful response to Zika, grounded in the country's long-standing dengue prevention and control program, serves as a model of rapid mobilization of intersectoral efforts. Sustaining this response requires applying the evidence generated within the Cuban dengue program that active community participation improves outcomes and is sustainable and cost-effective. There is also a need for implementation science efforts to assess the transferability of lessons learned from Zika prevention and control to other pathogens and from one context to another in addition to how to take these efforts to scale.

  12. Promoting healthy eating, active play and sustainability consciousness in early childhood curricula, addressing the Ben10™ problem: a randomised control trial.

    Science.gov (United States)

    Skouteris, Helen; Edwards, Susan; Rutherford, Leonie; Cutter-MacKenzie, Amy; Huang, Terry; O'Connor, Amanda

    2014-06-03

    This paper details the research protocol for a study funded by the Australian Research Council. An integrated approach towards helping young children respond to the significant pressures of '360 degree marketing' on their food choices, levels of active play, and sustainability consciousness via the early childhood curriculum is lacking. The overall goal of this study is to evaluate the efficacy of curriculum interventions that educators design when using a pedagogical communication strategy on children's knowledge about healthy eating, active play and the sustainability consequences of their toy food and toy selections. This cluster-randomised trial will be conducted with 300, 4 to 5 year-old children attending pre-school. Early childhood educators will develop a curriculum intervention using a pedagogical communication strategy that integrates content knowledge about healthy eating, active play and sustainability consciousness and deliver this to their pre-school class. Children will be interviewed about their knowledge of healthy eating, active play and the sustainability consequences of their food and toy selections. Parents will complete an Eating and Physical Activity Questionnaire rating their children's food preferences, digital media viewing and physical activity habits. All measures will be administered at baseline, the end of the intervention and 6 months post intervention. Informed consent will be obtained from all parents and the pre-school classes will be allocated randomly to the intervention or wait-list control group. This study is the first to utilise an integrated pedagogical communication strategy developed specifically for early childhood educators focusing on children's healthy eating, active play, and sustainability consciousness. The significance of the early childhood period, for young children's learning about healthy eating, active play and sustainability, is now unquestioned. The specific teaching and learning practices used by early

  13. Sustainability Science Needs Sustainable Data!

    Science.gov (United States)

    Downs, R. R.; Chen, R. S.

    2013-12-01

    Sustainability science (SS) is an 'emerging field of research dealing with the interactions between natural and social systems, and with how those interactions affect the challenge of sustainability: meeting the needs of present and future generations while substantially reducing poverty and conserving the planet's life support systems' (Kates, 2011; Clark, 2007). Bettencourt & Kaur (2011) identified more than 20,000 scientific papers published on SS topics since the 1980s with more than 35,000 distinct authors. They estimated that the field is currently growing exponentially, with the number of authors doubling approximately every 8 years. These scholars are undoubtedly using and generating a vast quantity and variety of data and information for both SS research and applications. Unfortunately we know little about what data the SS community is actually using, and whether or not the data that SS scholars generate are being preserved for future use. Moreover, since much SS research is conducted by cross-disciplinary, multi-institutional teams, often scattered around the world, there could well be increased risks of data loss, reduced data quality, inadequate documentation, and poor long-term access and usability. Capabilities and processes therefore need to be established today to support continual, reliable, and efficient preservation of and access to SS data in the future, especially so that they can be reused in conjunction with future data and for new studies not conceived in the original data collection activities. Today's long-term data stewardship challenges include establishing sustainable data governance to facilitate continuing management, selecting data to ensure that limited resources are focused on high priority SS data holdings, securing sufficient rights to allow unforeseen uses, and preparing data to enable use by future communities whose specific research and information needs are not yet known. Adopting sustainable models for archival

  14. Sustainable Marketing

    NARCIS (Netherlands)

    Dam, van Y.K.

    2017-01-01

    In this article, three different conceptions of sustainable marketing are discussed and compared. These different conceptions are referred to as social, green, and critical sustainable marketing. Social sustainable marketing follows the logic of demand-driven marketing management and places the

  15. THE DEVELOPMENT OF THE SME SECTOR – FUNDAMENT AND NECESSITY FOR SUSTAINABLE RELAUCHING OF THE ECONOMIC ACTIVITY IN ROMANIA

    Directory of Open Access Journals (Sweden)

    DOBROTĂ GABRIELA

    2014-05-01

    Full Text Available The increase of economic and financial welfare, the creation of new jobs, the assimilation of technological progress, economic, the increase of competitiveness internationally or reducing social inequities are a few aspects that highlight the necessity to stimulate the SME sector Small business sector dynamism is increasingly considered a factor which determine reviving and strengthening economic development. The development of private business medium in Romania has been adversely affected by extreme volatility and low capacity of predictability. To these were also added effects of the economic crisis, resulting in a severe reduction in the number of SMEs and a worsening of performance indicators. In the paper are presented a series of data, providing an overview of the SME sector in Romania and its contribution to the achievement of the economic growth process in the medium term. The research realised at the level of this important component of the economic environment has revealed that in Romania there are manifested a number of issues regarding the level of productivity, the profitability, contribution to gross value added and competitiveness on external plan. An analysis of economic and financial performance indicators (turnover, gross investments, gross value added, gross result of the exercise at the level of SMEs reflects the recording of negative values after 2008, which demonstrates once again the fragility of the economy in the face of major events but also the impact of the measures promoted by the government, the effects being very often contrary to those expected. The conclusions drawn from the study highlights the need to support the SME sector to ensure a sustainable economic growth and the stimulus measures differences by categories, activity sectors and growth rhythm.

  16. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity.

    Science.gov (United States)

    Reay, Jonathon L; Kennedy, David O; Scholey, Andrew B

    2005-07-01

    Single doses of the traditional herbal treatment Panax ginseng have recently been shown to elicit cognitive improvements in healthy young volunteers. The mechanisms by which ginseng improves cognitive performance are not known. However, they may be related to the glycaemic properties of some Panax species. Using a double-blind, placebo-controlled, balanced crossover design, 30 healthy young adults completed a 10 min test battery at baseline, and then six times in immediate succession commencing 60 min after the day's treatment (placebo, 200mg G115 or 400mg G115). The 10 min battery comprised a Serial Threes subtraction task (2 min); a Serial Sevens task (2 min); a Rapid Visual Information Processing task (5 min); then a 'mental fatigue' visual analogue scale. Blood glucose was measured prior to each day's treatment, and before, during and after the post-dose completions of the battery. Both the 200mg and 400mg treatments led to significant reductions in blood glucose levels at all three post-treatment measurements (p 0.005 in all cases). The most notable behavioural effects were associated with 200mg of ginseng and included significantly improved Serial Sevens subtraction task performance and significantly reduced subjective mental fatigue throughout all (with the exception of one time point in each case) of the post-dose completions of the 10 min battery (p 0.05). Overall these data suggest that Panax ginseng can improve performance and subjective feelings of mental fatigue during sustained mental activity. This effect may be related to the acute gluco-regulatory properties of the extract.

  17. Sustained Submicromolar H2O2 Levels Induce Hepcidin via Signal Transducer and Activator of Transcription 3 (STAT3)*

    Science.gov (United States)

    Millonig, Gunda; Ganzleben, Ingo; Peccerella, Teresa; Casanovas, Guillem; Brodziak-Jarosz, Lidia; Breitkopf-Heinlein, Katja; Dick, Tobias P.; Seitz, Helmut-Karl; Muckenthaler, Martina U.; Mueller, Sebastian

    2012-01-01

    The peptide hormone hepcidin regulates mammalian iron homeostasis by blocking ferroportin-mediated iron export from macrophages and the duodenum. During inflammation, hepcidin is strongly induced by interleukin 6, eventually leading to the anemia of chronic disease. Here we show that hepatoma cells and primary hepatocytes strongly up-regulate hepcidin when exposed to low concentrations of H2O2 (0.3–6 μm), concentrations that are comparable with levels of H2O2 released by inflammatory cells. In contrast, bolus treatment of H2O2 has no effect at low concentrations and even suppresses hepcidin at concentrations of >50 μm. H2O2 treatment synergistically stimulates hepcidin promoter activity in combination with recombinant interleukin-6 or bone morphogenetic protein-6 and in a manner that requires a functional STAT3-responsive element. The H2O2-mediated hepcidin induction requires STAT3 phosphorylation and is effectively blocked by siRNA-mediated STAT3 silencing, overexpression of SOCS3 (suppressor of cytokine signaling 3), and antioxidants such as N-acetylcysteine. Glycoprotein 130 (gp130) is required for H2O2 responsiveness, and Janus kinase 1 (JAK1) is required for adequate basal signaling, whereas Janus kinase 2 (JAK2) is dispensable upstream of STAT3. Importantly, hepcidin levels are also increased by intracellular H2O2 released from the respiratory chain in the presence of rotenone or antimycin A. Our results suggest a novel mechanism of hepcidin regulation by nanomolar levels of sustained H2O2. Thus, similar to cytokines, H2O2 provides an important regulatory link between inflammation and iron metabolism. PMID:22932892

  18. Statistical Detection of the He ii Transverse Proximity Effect: Evidence for Sustained Quasar Activity for >25 Million Years

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Tobias M. [Department of Physics, University of California, Santa Barbara, Santa Barbara, CA (United States); Max-Planck-Institut für Astronomie, Heidelberg (Germany); Worseck, Gabor [Max-Planck-Institut für Astronomie, Heidelberg (Germany); Hennawi, Joseph F. [Department of Physics, University of California, Santa Barbara, Santa Barbara, CA (United States); Max-Planck-Institut für Astronomie, Heidelberg (Germany); Prochaska, J. Xavier [Department of Astronomy and Astrophysics, UCO/Lick Observatory, University of California, Santa Cruz, Santa Cruz, CA (United States); Crighton, Neil H. M. [Centre for Astrophysics and Supercomputing, Swinburne University of Technology, Melbourne, VIC (Australia); Lukić, Zarija [Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Oñorbe, Jose, E-mail: tschmidt@mpia.de [Max-Planck-Institut für Astronomie, Heidelberg (Germany)

    2017-10-17

    The reionization of helium at z ~ 3 is the final phase transition of the intergalactic medium and supposed to be driven purely by quasars. The He ii transverse proximity effect—enhanced He ii transmission in a background sightline caused by the ionizing radiation of a foreground quasar—therefore offers a unique opportunity to probe the morphology of He ii reionization and to investigate the emission properties of quasars, e.g., ionizing emissivity, lifetime and beaming geometry. We use the most-recent HST/COS far-UV dataset of 22 He ii absorption spectra and conduct our own dedicated optical spectroscopic survey to find foreground quasars around these He ii sightlines. Based on a set of 66 foreground quasars, we perform the first statistical analysis of the He ii transverse proximity effect. Despite a large object-to-object variance, our stacking analysis reveals an excess in the average He ii transmission near the foreground quasars at 3σ significance. This statistical evidence for the transverse proximity effect is corroborated by a clear dependence of the signal strength on the inferred He ii ionization rate at the background sightline. Our detection places, based on the transverse light crossing time, a geometrical limit on the quasar lifetime of t{sub Q} > 25 Myr. This evidence for sustained activity of luminous quasars is relevant for the morphology of H i and He ii reionization and helps to constrain AGN triggering mechanisms, accretion physics and models of black hole mass assembly. We show how future modeling of the transverse proximity effect can additionally constrain quasar emission geometries and e.g., clarify if the large observed object-to-object variance can be explained by current models of quasar obscuration.

  19. Light Water Reactor Sustainability Program: Computer-based procedure for field activities: results from three evaluations at nuclear power plants

    International Nuclear Information System (INIS)

    2014-01-01

    Nearly all activities that involve human interaction with the systems of a nuclear power plant are guided by procedures. The paper-based procedures (PBPs) currently used by industry have a demonstrated history of ensuring safety; however, improving procedure use could yield tremendous savings in increased efficiency and safety. One potential way to improve procedure-based activities is through the use of computer-based procedures (CBPs). Computer-based procedures provide the opportunity to incorporate context driven job aids, such as drawings, photos, just-in-time training, etc into CBP system. One obvious advantage of this capability is reducing the time spent tracking down the applicable documentation. Additionally, human performance tools can be integrated in the CBP system in such way that helps the worker focus on the task rather than the tools. Some tools can be completely incorporated into the CBP system, such as pre-job briefs, placekeeping, correct component verification, and peer checks. Other tools can be partly integrated in a fashion that reduces the time and labor required, such as concurrent and independent verification. Another benefit of CBPs compared to PBPs is dynamic procedure presentation. PBPs are static documents which limits the degree to which the information presented can be tailored to the task and conditions when the procedure is executed. The CBP system could be configured to display only the relevant steps based on operating mode, plant status, and the task at hand. A dynamic presentation of the procedure (also known as context-sensitive procedures) will guide the user down the path of relevant steps based on the current conditions. This feature will reduce the user's workload and inherently reduce the risk of incorrectly marking a step as not applicable and the risk of incorrectly performing a step that should be marked as not applicable. As part of the Department of Energy's (DOE) Light Water Reactors Sustainability Program

  20. Enabling and sustaining the activities of lay health influencers: lessons from a community-based tobacco cessation intervention study.

    Science.gov (United States)

    Castañeda, Heide; Nichter, Mark; Nichter, Mimi; Muramoto, Myra

    2010-07-01

    The authors present findings from a community-based tobacco cessation project that trained lay health influencers to conduct brief interventions. They outline four major lessons regarding sustainability. First, participants were concerned about the impact that promoting cessation might have on social relationships. "Social risk" must be addressed during training to ensure long-term sustainability. Second, formal training provided participants with an increased sense of self-efficacy, allowed them to embrace a health influencer identity, and aided in further reducing social risk. Third, material resources functioned to mediate social tensions during health intervention conversations. A variety of resources should be made available to health influencers to accommodate type of relationship, timing, and location of the interaction. Finally, project design must be attentive to the creation of a "community of practice" among health influencers as an integral part of project sustainability. These lessons have broad implications for successful health promotion beyond tobacco cessation.

  1. Sustainable Disruptions

    DEFF Research Database (Denmark)

    Friis, Silje Alberthe Kamille; Kjær, Lykke Bloch

    2016-01-01

    Since 2012 the Sustainable Disruptions (SD) project at the Laboratory for Sustainability at Design School Kolding (DK) has developed and tested a set of design thinking tools, specifically targeting the barriers to economically, socially, and environmentally sustainable business development....... The tools have been applied in practice in collaboration with 11 small and medium sized companies (SMEs). The study investigates these approaches to further understand how design thinking can contribute to sustainable transition in a business context. The study and the findings are relevant to organizations...... invested in the issue of sustainable business development, in particular the leaders and employees of SMEs, but also to design education seeking new ways to consciously handle and teach the complexity inherent in sustainable transformation. Findings indicate that the SD design thinking approach contributes...

  2. Computational sustainability

    CERN Document Server

    Kersting, Kristian; Morik, Katharina

    2016-01-01

    The book at hand gives an overview of the state of the art research in Computational Sustainability as well as case studies of different application scenarios. This covers topics such as renewable energy supply, energy storage and e-mobility, efficiency in data centers and networks, sustainable food and water supply, sustainable health, industrial production and quality, etc. The book describes computational methods and possible application scenarios.

  3. Sustainable Universities

    DEFF Research Database (Denmark)

    Grindsted, Thomas Skou

    2011-01-01

    Declarations on Sustainability in Higher Education (SHE) can be viewed as a piece of international regulation. Over the past 30 years research at universities has produced convincing data to warn about deterioration of the environment, resource scarcity and the need for sustainability. This in turn....... Declarations tend to have impact on three trends. Firstly, there is emerging international consensus on the university’s role and function in relation to sustainable development; secondly, the emergence of national legislation, and thirdly, an emerging international competition to be leader in sustainable...

  4. Presenting "recious Knowledge": Using Film to Model Culturally Sustaining Pedagogy and Youth Civic Activism for Social Studies Teachers

    Science.gov (United States)

    Parkhouse, Hillary

    2015-01-01

    In this article, I examine the potential for developing preservice social studies teachers' understanding of transformational resistance, Latin@ civil rights movements, and culturally sustaining pedagogy through a project using the film Precious Knowledge. This documentary depicts high school students in a Mexican American Studies (MAS) program…

  5. Sustaining Participatory Design Initiatives

    DEFF Research Database (Denmark)

    Iversen, Ole Sejer; Dindler, Christian

    2014-01-01

    While many participatory design (PD) projects succeed in establishing new organisational initiatives or creating technology that is attuned to the people affected, the issue of how such results are sustained after the project ends remains an important challenge. We explore the challenge...... these various forms of sustainability may be pursued in PD practice and how they can become a resource in reflecting on PD activities. Finally, we discuss implications for PD practice, suggesting that a nuanced conception of sustainability and how it may relate to PD practice are useful resources for designers...... of sustaining PD initiatives beyond the individual project and discuss implications for PD practice. First, based on current PD literature, we distinguish between four ideal typical forms of sustainability: maintaining, scaling, replicating and evolving. Second, we demonstrate from a case study how...

  6. Sustainability and Organizational Change

    Directory of Open Access Journals (Sweden)

    Catălina Sitnikov

    2012-06-01

    Full Text Available The relevant and, above all, remarkable feature of sustainability is due to its "duality": on the one hand, it is an indispensable element within the companies even if, on the other hand, it increases the costs of many activities and processes. Facing the challenge of sustainability will determine and create, in the coming years, emerging organizational forms. If ten years ago, many managers clearly expressed their doubts regarding the financial feasibility of sustainability, today, they admit the importance of sustainability for the competitive advantage of the companies they manage. Currently, companies have great opportunities to support build a sustainable global economy, becoming one of the solutions to the most pressing societal challenges. Whether it is about reducing pollution, global warming, reducing use of water resources and other limited resources or ensuring a better work environment for employees throughout the supply chain, there are many things that companies can and should do.

  7. ANDRA - National Radioactive Waste Management Agency. Activity report 2008 - Fostering dialogue and outreach. Management report - Financial statements at December 31, 2008. Annual Sustainable Development Report 2008 - From strategy to initial actions: Andra's sustained commitment

    International Nuclear Information System (INIS)

    2009-06-01

    Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity report, with the management and financial statements report, and the Sustainable Development Report of the Andra for the year 2008

  8. Sustainable Agricultural Marketing Initiatives

    Directory of Open Access Journals (Sweden)

    Hakan Adanacıoğlu

    2015-07-01

    Full Text Available Sustainable marketing is a holistic approach that puts equal emphasis on environmental, social equity, and economic concerns in the development of marketing strategies. The purpose of the study is to examine and discuss the sustainable agricultural marketing initiatives practiced throughout the World and Turkey, and to put forth suggestions to further improve the performance of agricultural marketing initiatives in Turkey. Some of the sustainable agricultural marketing initiatives practiced around the world are carried out through civil organizations. Furthermore; some of these initiatives have also launched by farmers, consumers, food processors and retailers. The long-term strategies to increase these initiatives should be determined due to the fact that examples of successful sustainable agricultural marketing initiatives are inadequate and cannot be spread in Turkey. In this context, first of all, the supports provided by the government to improve agricultural marketing systems, such as EU funds for rural development should be compatible with the goals of sustainable marketing. For this purpose, it should be examined whether all proposed projects related to agricultural marketing meet the social, economic, and environmental principles of sustainable marketing. It is important that supporting organizations, especially civil society organisations, should take an active role for faster dissemination and adoption of sustainable agricultural marketing practices in Turkey. These organizations may provide technical assistance in preparing successful project proposals and training to farm groups. In addition, the other organizations, such as local administrations, producers' associations, cooperatives, can contribute to the success of sustainable agricultural marketing initiatives. The use of direct marketing strategies and vertical integration attempts in sustainable agricultural marketing initiatives that will likely be implemented in Turkey is

  9. Sustainable Transition

    DEFF Research Database (Denmark)

    Hansen, Ole Erik; Søndergård, Bent

    2014-01-01

    of agendas/vision, technologies, actors and institutions in the emergent design of an urban mobility system based on an electric car sharing system. Why. Designing for sustainability is a fundamental challenge for future design practices; designers have to obtain an ability to contribute to sustainable...

  10. Sustainable transformation

    DEFF Research Database (Denmark)

    Andersen, Nicolai Bo

    This paper is about sustainable transformation with a particular focus on listed buildings. It is based on the notion that sustainability is not just a question of energy conditions, but also about the building being robust. Robust architecture means that the building can be maintained and rebuil...

  11. Sustainability Labeling

    NARCIS (Netherlands)

    Dam, van Y.K.

    2017-01-01

    Sustainability labeling originated from a need to protect the identity of alternative systems of food production and to increase market transparency. From the 1980s onwards sustainability labeling has changed into a policy instrument replacing direct government regulation of the food market, and a

  12. Afterschool Sustainability

    Directory of Open Access Journals (Sweden)

    Hilary D. Joyce

    2014-12-01

    Full Text Available Youth participation in quality extended learning opportunities (ELOs results in positive academic, physical, mental health, and social/emotional outcomes. Funding is essential to implementing and sustaining quality ELOs; however multiple funding barriers and challenges exist. Understanding the types of funds available for ELOs and the factors that influence sustainability is critical. Through surveys and telephone interviews of ELO providers, this descriptive study identified and examined ELO funding streams, the ways ELO providers use these funding streams, and the barriers and challenges to sustainability. ELO programs often relied on one major funding stream coupled with nutrition supports as well as in-kind resources. Barriers to sustainability included year-to-year funding, transportation costs, reducing community partnerships, and difficulty in diversifying funds. Recommendations to enhance ELO sustainability are offered, particularly in relation to overcoming the challenges to diversification of funding resources and establishing mutually supportive partnerships and collaboration.

  13. Sustainable Lifestyle Marketing of Individuals: the Base of Sustainability

    Directory of Open Access Journals (Sweden)

    Mira Rakic

    2015-08-01

    Full Text Available This paper highlights the sustainable lifestyle marketing of an individual (SLMOI. The SLMOI is the activity, a set of institutions and processes for creating, communicating and maintaining the sustainable lifestyle of an individual (SLOI. The SLOI is an individual’s sustainability-oriented pattern of living represented by his or her activities, interests and opinions. The SLOI refers to a sustainable pattern of life (daily activities within the family, a sustainable pattern of consumption, a sustainable pattern of work and production (as employees in organizations and a sustainable pattern of behavior in the society and the environment they live in. The SLOI reflects an individual’s choices with respect to spending time, money and energy in accordance with the sustainable pattern of life. The SLOI stands for sustainable behavioral patterns on the basis of attitudes and values. The purpose of this paper is to investigate the attitudes of the population towards sustainable lifestyles and the SLMOI (performed by different actors and behaviors on the basis of attitudes.Using a face-to-face questionnaire interview, the study was conducted on a sample of 400 citizens of Serbia. There are three key conclusions. First, the SLMOI leads to the SLOI, and the SLOI further leads to sustainability. Second, the creation and maintenance of the SLOI is a long-term process. Third, a holistic approach is needed as well as the engagement of numerous actors in that process of creating and maintaining the SLOI.

  14. Carbohydrate administration during a day of sustained aerobic activity improves vigilance, as assessed by a novel ambulatory monitoring device, and mood.

    Science.gov (United States)

    Lieberman, Harris R; Falco, Christina M; Slade, Steven S

    2002-07-01

    The brain requires a continuous supply of glucose to function adequately. During aerobic exercise, peripheral glucose requirements increase and carbohydrate supplementation improves physical performance. The brain's utilization of glucose also increases during aerobic exercise. However, the effects of energy supplementation on cognitive function during sustained aerobic exercise are not well characterized. The effects of energy supplementation, as liquid carbohydrate, on cognitive function during sustained aerobic activity were examined. A double-blind, placebo-controlled, between-subjects design was used. Young, healthy men (n = 143) were randomly assigned to 1 of 3 treatment groups. The groups received either a 6% (by vol) carbohydrate (35.1 kJ/kg), 12% (by vol) carbohydrate (70.2 kJ/kg), or placebo beverage in 6 isovolumic doses, and all groups consumed 2 meals (3200 kJ). Over the 10-h study, the subjects performed physically demanding tasks, including a 19.3-km road march and two 4.8-km runs, interspersed with rest and other activities. Wrist-worn vigilance monitors, which emitted auditory stimuli (20/h) to which the subjects responded as rapidly as possible, and a standardized self-report mood questionnaire were used to assess cognitive function. Vigilance consistently improved with supplemental carbohydrates in a dose-related manner; the 12% carbohydrate group performed the best and the placebo group the worst (P Mood-questionnaire results corroborated the results from the monitors; the subjects who received carbohydrates reported less confusion (P = 0.040) and greater vigor (P = 0.025) than did those who received the placebo. Supplemental carbohydrate beverages enhance vigilance and mood during sustained physical activity and interspersed rest. In addition, ambulatory monitoring devices can continuously assess the effects of nutritional factors on cognition as individuals conduct their daily activities or participate in experiments.

  15. Sustainable Biofuels Development Center

    Energy Technology Data Exchange (ETDEWEB)

    Reardon, Kenneth F. [Colorado State Univ., Fort Collins, CO (United States)

    2015-03-01

    The mission of the Sustainable Bioenergy Development Center (SBDC) is to enhance the capability of America’s bioenergy industry to produce transportation fuels and chemical feedstocks on a large scale, with significant energy yields, at competitive cost, through sustainable production techniques. Research within the SBDC is organized in five areas: (1) Development of Sustainable Crops and Agricultural Strategies, (2) Improvement of Biomass Processing Technologies, (3) Biofuel Characterization and Engine Adaptation, (4) Production of Byproducts for Sustainable Biorefining, and (5) Sustainability Assessment, including evaluation of the ecosystem/climate change implication of center research and evaluation of the policy implications of widespread production and utilization of bioenergy. The overall goal of this project is to develop new sustainable bioenergy-related technologies. To achieve that goal, three specific activities were supported with DOE funds: bioenergy-related research initiation projects, bioenergy research and education via support of undergraduate and graduate students, and Research Support Activities (equipment purchases, travel to attend bioenergy conferences, and seminars). Numerous research findings in diverse fields related to bioenergy were produced from these activities and are summarized in this report.

  16. Sustainable Cities

    DEFF Research Database (Denmark)

    Georg, Susse; Garza de Linde, Gabriela Lucía

    Judging from the number of communities and cities striving or claiming to be sustainable and how often eco-development is invoked as the means for urban regeneration, it appears that sustainable and eco-development have become “the leading paradigm within urban development” (Whitehead 2003....../assessment tool. The context for our study is urban regeneration in one Danish city, which had been suffering from industrial decline and which is currently investing in establishing a “sustainable city”. Based on this case study we explore how the insights and inspiration evoked in working with the tool...

  17. Infliximab Dose Reduction Sustains the Clinical Treatment Effect in Active HLAB27 Positive Ankylosing Spondylitis: A Two-Year Pilot Study

    Directory of Open Access Journals (Sweden)

    Boel Mörck

    2013-01-01

    Full Text Available The rationale of the study was to evaluate the efficacy of infliximab (IFX treatment in patients with ankylosing spondylitis (AS and to determine whether IFX dose reduction and interval extension sustains the treatment effect. Nineteen patients were included and treated with IFX 5 mg/kg every 6 weeks for 56 weeks. All patients concomitantly received MTX with median dose 7.5 mg/weekly. During the second year, the IFX dose was reduced to 3 mg/kg every 8 weeks. Eighteen patients completed the 1-year and 15 patients the 2-year trial. The ≥50% improvement at week 16 from baseline of BASDAI was achieved in 16/19 (84% patients. Significant reductions in BASDAI, BASFI, and BASMI scores, decrease in ESR and CRP, and improvement in SF-36 were observed at weeks 16 and 56. The MRI-defined inflammatory changes in the sacroiliac joints disappeared in 10/15 patients (67% already at 16 weeks. IFX treatment effect was sustained throughout the second year after IFX dose reduction and interval extension. We conclude that IFX treatment is effective in well-established active AS and a dose reduction sustains the treatment effect. These observations are of clinical importance and open the opportunity to reduce the drug costs. This trial is registered with ClinicalTrials.gov NCT01850121.

  18. Sustainability dilemmas in emerging economies

    Directory of Open Access Journals (Sweden)

    Rama K. Jayanti

    2014-06-01

    Full Text Available Increasing evidence of climate change is forcing businesses to play an active role in reducing sustainability burdens and preserving resources for future generations. Extant research on sustainability has an exclusive focus on developed countries with stringent environmental regulations and activist scrutiny. Emerging markets present interesting dilemmas since rapid mass urbanisation aimed at raising standards of living poses concomitant threats to environmental health. This round table aimed to showcase best practices in sustainability within the Indian business context. Insights from the discussion regarding sustainability dilemmas provide a fertile ground for bench marking global sustainability best practices.

  19. A New Agenda for Sustainability

    DEFF Research Database (Denmark)

    Aagaard Nielsen, Kurt

    Two decades after the Brundtland Commission's Report "Our Common Future" adopted the concept of 'sustainable development', this book provides a renewal of the concept exploring the potential for new practices and fields for those involved in sustainability activity. The book addresses a number...... on sustainability. The material dealt with in the book offers a wide variety of perspectives on sustainability and reflects the importance of interdisciplinary and transdiciplinary work in the field. Suggesting targets for future analytical and political efforts in achieving global sustainability, this book offers...

  20. Agriculture: Sustainability

    Science.gov (United States)

    Sustainability creates and maintains the conditions under which humans and nature can exist in productive harmony, that permit fulfilling the food, feed, and fiber needs of our country and the social, economic and other requirements.

  1. Sustainable consumption

    DEFF Research Database (Denmark)

    Prothero, Andrea; Dobscha, Susan; Freund, Jim

    2011-01-01

    This essay explores sustainable consumption and considers possible roles for marketing and consumer researchers and public policy makers in addressing the many sustainability challenges that pervade our planet. Future research approaches to this interdisciplinary topic need to be comprehensive...... and systematic and will benefit from a variety of different perspectives. There are a number of opportunities for future research, and three areas are explored in detail. First, the essay considers the inconsistency between the attitudes and behaviors of consumers with respect to sustainability; next, the agenda...... is broadened to explore the role of individual citizens in society; and finally, a macro institutional approach to fostering sustainability is explored. Each of these areas is examined in detail and possible research avenues and public policy initiatives are considered within each of these separate...

  2. Sustainable Futures

    Science.gov (United States)

    Sustainable Futures is a voluntary program that encourages industry to use predictive models to screen new chemicals early in the development process and offers incentives to companies subject to TSCA section 5.

  3. Sustainability reporting

    NARCIS (Netherlands)

    Kolk, A.

    2005-01-01

    This article gives an overview of developments in sustainability (also sometimes labelled corporate social responsibility) reporting. The article will first briefly indicate how accountability on social and environmental issues started, already in the 1970s when social reports were published.

  4. Sustainable transformation

    DEFF Research Database (Denmark)

    Andersen, Nicolai Bo

    This paper is about sustainable transformation with a particular focus on listed buildings. It is based on the notion that sustainability is not just a question of energy conditions, but also about the building being robust. Robust architecture means that the building can be maintained and rebuilt......, that it can be adapted to changing functional needs, and that it has an architectural and cultural value. A specific proposal for a transformation that enhances the architectural qualities and building heritage values of an existing building forms the empirical material, which is discussed using different...... theoretical lenses. It is proposed that three parameters concerning the ꞌtransformabilityꞌ of the building can contribute to a more nuanced understanding of sustainable transformation: technical aspects, programmatic requirements and narrative value. It is proposed that the concept of ꞌsustainable...

  5. Stabilizing Sustainability

    DEFF Research Database (Denmark)

    Reitan Andersen, Kirsti

    The publication of the Brundtland Report in 1987 put the topic of sustainable development on the political and corporate agenda. Defining sustainable development as “a development that meets the needs of the future without compromising the ability of future generations to meet their own needs......” (WCED, 1987, p. 43), the Report also put a positive spin on the issue of sustainability by upholding capitalist beliefs in the possibility of infinite growth in a world of finite resources. While growth has delivered benefits, however, it has done so unequally and unsustainably. This thesis focuses...... on the textile and fashion industry, one of the world’s most polluting industries and an industry to some degree notorious for leading the ‘race to the bottom’ in global labour standards. Despite being faced with increasing demands to practise sustainability, most textile and fashion companies continue to fail...

  6. Seeking Sustainability

    OpenAIRE

    Clive L. Spash

    2014-01-01

    What does sustainability research do to help the environment? One might well wonder when observing the annual conference season with various academics and professors in sustainability science, ecological economics or environmental ethics driving to the airport to fly off to international meetings to discuss how bad things are getting, what should been done about it, and how time is running out for action. In fact, singling out a few academic groups is highly unfair because the link between pr...

  7. Local Sustainability

    International Nuclear Information System (INIS)

    Carrizosa Umana, Julio

    1998-01-01

    The current polemic about the possibilities of sustainable development has led to a renovated interest for the topic of the sustainability of the communities and the local sustainability. In front of the global sustainability whose conditions have been exposed by systemic ecologists and for macro economists, the sustainability of specific places arises in the planet whose conditions are object of study of the ecology of landscapes, of the ecological economy, of the cultural anthropology, of the environmental sociology and naturally, of the integral environmentalism. In this discussion the Colombian case charges unusual interest to be one of the few countries of Latin America, where a very dense net of municipalities exists, each one with its urban helmet and with a position and some functions defined by the political constitution of the nation. This net of municipalities and of urban helmets it also constitutes net of alternative to the current macro-cephalic situation. As well as Bogota grew, in a hundred years, of less than a hundred thousand inhabitants to six million inhabitants, each one of these municipalities contains a potential of growth that depends on the characteristics of its ecological, social, economic and politic sustainability

  8. Sustainable markets for sustainable energy

    Energy Technology Data Exchange (ETDEWEB)

    Millan, J.; Smyser, C.

    1997-12-01

    The author discusses how the Inter-American Development Bank (IDB) is involved in sustainable energy development. It presently has 50 loans and grants for non conventional renewable energy projects and ten grants for efficiency programs for $600 and $17 million respectively, representing 100 MW of power. The IDB is concerned with how to create a sustainable market for sustainable energy projects. The IDB is trying to work with government, private sector, NGOs, trading allies, credit sources, and regulators to find proper roles for such projects. He discusses how the IDB is working to expand its vision and objectives in renewable energy projects in Central and South America.

  9. Sustained posterior contralateral activity indicates re-entrant target processing in visual change detection: An EEG study

    Directory of Open Access Journals (Sweden)

    Daniel eSchneider

    2014-05-01

    Full Text Available The present study investigated the neural mechanisms that contribute to the detection of visual feature changes between stimulus displays by means of event-related lateralizations of the electroencephalogram (EEG. Participants were instructed to respond to a luminance change in either of two lateralized stimuli that could randomly occur alone or together with an irrelevant orientation change of the same or contralateral stimulus. Task performance based on response times and accuracy was decreased compared to the remaining stimulus conditions when relevant and irrelevant feature changes were presented contralateral to each other (lateral distractor condition. The sensory response to the feature changes was reflected in a posterior contralateral positivity at around 100ms after change presentation and a posterior contralateral negativity in the N1 time window (N1pc. N2pc reflected a subsequent attentional bias in favor of the relevant luminance change. The continuation of the sustained posterior contralateral negativity (SPCN following N2pc covaried with response times within feature change conditions and revealed a posterior topography comparable to the earlier components associated with sensory and attentional mechanisms. Therefore, this component might reflect the re-processing of information based on sustained short-term memory representations in the visual system until a stable target percept is created that can serve as the perceptual basis for response selection and the initiation of goal-directed behavior.

  10. Environmentally Sustainable Economic Growth

    Directory of Open Access Journals (Sweden)

    Stelian Brad

    2016-05-01

    Full Text Available Economic growth and sustainable development are important issues for social prosperity. Sustainable development strives for moderate and responsible use within the economic activity of the limited resources of our planet, whereas economic growth does not limit the resource exploitation and energy, being mainly focused on productivity increase. From this perspective, both conceptual and operational contradictions occur between the two pillars of prosperity. This paper looks to these contradictions and proposes some streams of intervention such as economic growth and environmental sustainability to operate in harmony. A structured framework for innovative problem solving is considered in this respect. Results of this research show that it is possible to induce smart measures in the economic system for directing businesses towards new paradigms where economic growth is possible without negative effects on environmental sustainability.

  11. Is Earth F**ked? Dynamical Futility of Global Environmental Management and Possibilities for Sustainability via Direct Action Activism

    Science.gov (United States)

    wErnEr, B.

    2012-12-01

    Environmental challenges are dynamically generated within the dominant global culture principally by the mismatch between short-time-scale market and political forces driving resource extraction/use and longer-time-scale accommodations of the Earth system to these changes. Increasing resource demand is leading to the development of two-way, nonlinear interactions between human societies and environmental systems that are becoming global in extent, either through globalized markets and other institutions or through coupling to global environmental systems such as climate. These trends are further intensified by dissipation-reducing technological advances in transactions, communication and transport, which suppress emergence of longer-time-scale economic and political levels of description and facilitate long-distance connections, and by predictive environmental modeling, which strengthens human connections to a short-time-scale virtual Earth, and weakens connections to the longer time scales of the actual Earth. Environmental management seeks to steer fast scale economic and political interests of a coupled human-environmental system towards longer-time-scale consideration of benefits and costs by operating within the confines of the dominant culture using a linear, engineering-type connection to the system. Perhaps as evidenced by widespread inability to meaningfully address such global environmental challenges as climate change and soil degradation, nonlinear connections reduce the ability of managers to operate outside coupled human-environmental systems, decreasing their effectiveness in steering towards sustainable interactions and resulting in managers slaved to short-to-intermediate-term interests. In sum, the dynamics of the global coupled human-environmental system within the dominant culture precludes management for stable, sustainable pathways and promotes instability. Environmental direct action, resistance taken from outside the dominant culture, as in

  12. Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation

    Science.gov (United States)

    Mita, Mitsuo; Tanaka, Hitoshi; Yanagihara, Hayato; Nakagawa, Jun-ichi; Hishinuma, Shigeru; Sutherland, Cindy; Walsh, Michael P.; Shoji, Masaru

    2013-01-01

    Rho-associated kinase (ROK) activation plays an important role in K+-induced contraction of rat caudal arterial smooth muscle (Mita et al., Biochem J. 2002; 364: 431–40). The present study investigated a potential role for tyrosine kinase activity in K+-induced RhoA activation and contraction. The non-selective tyrosine kinase inhibitor genistein, but not the src family tyrosine kinase inhibitor PP2, inhibited K+-induced sustained contraction (IC50 = 11.3 ± 2.4 µM). Genistein (10 µM) inhibited the K+-induced increase in myosin light chain (LC20) phosphorylation without affecting the Ca2+ transient. The tyrosine phosphatase inhibitor vanadate induced contraction that was reversed by genistein (IC50 = 6.5 ± 2.3 µM) and the ROK inhibitor Y-27632 (IC50 = 0.27 ± 0.04 µM). Vanadate also increased LC20 phosphorylation in a genistein- and Y-27632-dependent manner. K+ stimulation induced translocation of RhoA to the membrane, which was inhibited by genistein. Phosphorylation of MYPT1 (myosin-targeting subunit of myosin light chain phosphatase) was significantly increased at Thr855 and Thr697 by K+ stimulation in a genistein- and Y-27632-sensitive manner. Finally, K+ stimulation induced genistein-sensitive tyrosine phosphorylation of proteins of ∼55, 70 and 113 kDa. We conclude that a genistein-sensitive tyrosine kinase, activated by the membrane depolarization-induced increase in [Ca2+]i, is involved in the RhoA/ROK activation and sustained contraction induced by K+. Ca2+ sensitization, myosin light chain phosphatase, RhoA, Rho-associated kinase, tyrosine kinase PMID:24133693

  13. PGC-1α-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells.

    Science.gov (United States)

    Miranda, Dante; Jara, Claudia; Ibañez, Jorge; Ahumada, Viviana; Acuña-Castillo, Claudio; Martin, Adrian; Córdova, Alexandra; Montoya, Margarita

    2016-01-01

    Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in antitumor defense reactions. NK cell effector functions are critically dependent on cytokines and metabolic activity. Among various cytokines modulating NK cell function, interleukin-2 (IL-2) can induce a more potent cytotoxic activity defined as lymphokine activated killer activity (LAK). Our aim was to determine if IL-2 induces changes at the mitochondrial level in NK cells to support the bioenergetic demand for performing this enhanced cytotoxic activity more efficiently. Purified human NK cells were cultured with high IL-2 concentrations to develop LAK activity, which was assessed by the ability of NK cells to lyse NK-resistant Daudi cells. Here we show that, after 72 h of culture of purified human NK cells with enough IL-2 to induce LAK activity, both the mitochondrial mass and the mitochondrial membrane potential increased in a PGC-1α-dependent manner. In addition, oligomycin, an inhibitor of ATP synthase, inhibited IL-2-induced LAK activity at 48 and 72 h of culture. Moreover, the secretion of IFN-γ from NK cells with LAK activity was also partially dependent on PGC-1α expression. These results indicate that PGC-1α plays a crucial role in regulating mitochondrial function involved in the maintenance of LAK activity in human NK cells stimulated with IL-2.

  14. 2017 NEA Annual Report: Nuclear Power in 2017; Innovation and Education: Necessary Enablers for Sustainable Nuclear Energy, or the Virtuous Circle; NEA Activities by Sector

    International Nuclear Information System (INIS)

    2018-01-01

    The NEA Annual Report of the OECD Nuclear Energy Agency (NEA) for the year ending on 31 December 2017 provides an overview of the status of nuclear power in OECD countries and illustrative descriptions of the Agency's activities and international joint projects. Content: 1 - Message from the Director-General; 2 - Innovation and Education: Necessary Enablers for Sustainable Nuclear Energy, or the Virtuous Circle; 3 - Nuclear Technology in 2017; 4 - NEA Activities by Sector: Nuclear Development, Nuclear Safety and Regulation, Human Aspects of Nuclear Safety, Radiological Protection, Radioactive Waste Management, Nuclear Science, Data Bank, Legal Affairs, 5 - General Information: Information and Communications, Organisational Structure of the NEA, NEA Committee Structure in 2017, NEA Management Structure in 2017, NEA Publications and Brochures Produced in 2017

  15. Roundtabling Sustainability

    DEFF Research Database (Denmark)

    Ponte, Stefano

    2014-01-01

    councils’ and ‘sustainability roundtables’ and have been designed around a set of institutional features seeking to establish legitimacy, fend off possible criticism, and ‘sell’ certifications to potential users. The concept of ‘roundtabling’ emphasizes the fitting a variety of commodity...... and procedures to meet ‘good practice’ in standard setting and management. This is opening space for competing initiatives that are less democratic, quicker, and more aligned with industry interests to establish substantial presence in the market for sustainability certifications. These tend to more easily...

  16. Sustainability and Competitiveness of Tourism

    OpenAIRE

    Angelkova, Tanja; Koteski, Cane; Jakovlev, Zlatko; Mitreva, Elizabeta

    2011-01-01

    Tourism is an activity that can have a really big impact on sustainable development. Sustainability of tourism involves extensive cooperation between tourist companies, tourist destinations and national, regional and local authorities in order to cover a broad group of challenges and at the same time to remain competitive. Opportunities for sustainable tourism development and preservation of its competitiveness, largely influenced by the quality of the environment, preserved and attractive...

  17. Sustainable management of agriculture activity on areas with soil vulnerability to compaction trough a developed decision support system (DSS)

    Science.gov (United States)

    Moretto, Johnny; Fantinato, Luciano; Rasera, Roberto

    2017-04-01

    One of the main environmental effects of agriculture is the negative impacts on areas with soil vulnerability to compaction and undersurface water derived from inputs and treatment distributions. A solution may represented from the "Precision Farming". Precision Farming refers to a management concept focusing on (near-real time) observation, measurement and responses to inter- and intra-variability in crops, fields and animals. Potential benefits may include increasing crop yields and animal performance, cost and labour reduction and optimisation of process inputs, all of which would increase profitability. At the same time, Precision Farming should increase work safety and reduce the environmental impacts of agriculture and farming practices, thus contributing to the sustainability of agricultural production. The concept has been made possible by the rapid development of ICT-based sensor technologies and procedures along with dedicated software that, in the case of arable farming, provides the link between spatially-distributed variables and appropriate farming practices such as tillage, seeding, fertilisation, herbicide and pesticide application, and harvesting. Much progress has been made in terms of technical solutions, but major steps are still required for the introduction of this approach over the common agricultural practices. There are currently a large number of sensors capable of collecting data for various applications (e.g. Index of vegetation vigor, soil moisture, Digital Elevation Models, meteorology, etc.). The resulting large volumes of data need to be standardised, processed and integrated using metadata analysis of spatial information, to generate useful input for decision-support systems. In this context, a user-friendly IT applications has been developed, for organizing and processing large volumes of data from different types of remote sensing and meteorological sensors, and for integrating these data into user-friendly farm management support

  18. Report on Childhood Obesity in China (8): Effects and Sustainability of Physical Activity Intervention on Body Composition of Chinese Youth

    NARCIS (Netherlands)

    Li, Y.P.; Hu, X.Q.; Schouten, E.G.; Liu, A.L.; Du, S.M.; Li, L.Z.; Cui, Z.H.; Wang, D.; Kok, F.J.; Hu, F.B.; Ma, G.S.

    2010-01-01

    Objectives To determine whether a large-scale physical activity intervention could affect body composition in primary school students in Beijing, China. Methods The study design was one-year cluster randomized controlled trial of physical activity intervention (20 min of daily exercise in the

  19. Twitter as a Teaching Practice to Enhance Active and Informal Learning in Higher Education: The Case of Sustainable Tweets

    Science.gov (United States)

    Kassens-Noor, Eva

    2012-01-01

    With the rise of Web 2.0, a multitude of new possibilities on how to use these online technologies for active learning has intrigued researchers. While most instructors have used Twitter for in-class discussions, this study explores the teaching practice of Twitter as an active, informal, outside-of-class learning tool. Through a comparative…

  20. Sustainable finance

    NARCIS (Netherlands)

    Boersma-de Jong, Margreet F.

    2012-01-01

    Presentation for Springschool of Strategy, University of Groningen, 10 October 2012. The role of CSR is to stimulate ethical behaviour, and as a result, mutual trust in society. Advantage of CSR for the company and the evolution of CSR. From CSR to Sustainable Finance: how does CSR influence

  1. Sustainable Procurement

    DEFF Research Database (Denmark)

    Telles, Pedro; Ølykke, Grith Skovgaard

    2017-01-01

    and within it how sustainable requirements have increased the level of compliance required, particularly regulatory compliance. Compliance was already present in previous EU public procurement frameworks, but its extent on Directive 2014/24/EU leads the authors to consider the current legal framework...

  2. Exergy sustainability.

    Energy Technology Data Exchange (ETDEWEB)

    Robinett, Rush D. III (.; ); Wilson, David Gerald; Reed, Alfred W.

    2006-05-01

    Exergy is the elixir of life. Exergy is that portion of energy available to do work. Elixir is defined as a substance held capable of prolonging life indefinitely, which implies sustainability of life. In terms of mathematics and engineering, exergy sustainability is defined as the continuous compensation of irreversible entropy production in an open system with an impedance and capacity-matched persistent exergy source. Irreversible and nonequilibrium thermodynamic concepts are combined with self-organizing systems theories as well as nonlinear control and stability analyses to explain this definition. In particular, this paper provides a missing link in the analysis of self-organizing systems: a tie between irreversible thermodynamics and Hamiltonian systems. As a result of this work, the concept of ''on the edge of chaos'' is formulated as a set of necessary and sufficient conditions for stability and performance of sustainable systems. This interplay between exergy rate and irreversible entropy production rate can be described as Yin and Yang control: the dialectic synthesis of opposing power flows. In addition, exergy is shown to be a fundamental driver and necessary input for sustainable systems, since exergy input in the form of power is a single point of failure for self-organizing, adaptable systems.

  3. Sustainable Buildings

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.; Elle, Morten

    The scientific community agrees that: all countries must drastically and rapidly reduce their CO2 emissions and that energy efficient houses play a decisive role in this. The general attitude at the workshop on Sustainable Buildings was that we face large and serious climate change problems...

  4. Sustainable Entrepreneurship

    DEFF Research Database (Denmark)

    Schaltegger, Stefan; Beckmann, Markus; Hockerts, Kai

    2018-01-01

    . We also explore the transformation path of the case company, which starts with simple use and then moves to the feedback to core business pattern. By drawing on insights from lead user theory in innovation management and sustainable entrepreneurship, we ground the new concept in extant literature...

  5. Sustainable machining

    CERN Document Server

    2017-01-01

    This book provides an overview on current sustainable machining. Its chapters cover the concept in economic, social and environmental dimensions. It provides the reader with proper ways to handle several pollutants produced during the machining process. The book is useful on both undergraduate and postgraduate levels and it is of interest to all those working with manufacturing and machining technology.

  6. Sustainable processing

    DEFF Research Database (Denmark)

    Kristensen, Niels Heine

    2004-01-01

    Kristensen_NH and_Beck A: Sustainable processing. In Otto Schmid, Alexander Beck and Ursula Kretzschmar (Editors) (2004): Underlying Principles in Organic and "Low-Input Food" Processing - Literature Survey. Research Institute of Organic Agriculture FiBL, CH-5070 Frick, Switzerland. ISBN 3-906081-58-3...

  7. Architecture Sustainability

    NARCIS (Netherlands)

    Avgeriou, Paris; Stal, Michael; Hilliard, Rich

    2013-01-01

    Software architecture is the foundation of software system development, encompassing a system's architects' and stakeholders' strategic decisions. A special issue of IEEE Software is intended to raise awareness of architecture sustainability issues and increase interest and work in the area. The

  8. Sustainable development

    International Nuclear Information System (INIS)

    Boiteux, M.

    2004-01-01

    Marcel Boiteux evokes the results of the work on the sustainable development by the Academie des Sciences Morales et Politiques. This is a vast political programme with the goal of allowing all humanity to live well in growing unity while protecting the environment and favouring economic growth. (author)

  9. Sustainable Development

    African Journals Online (AJOL)

    Tsegai Berhane Ghebretekle

    Ethiopia is selected as a case study in light of its pace in economic growth ... Interrogating the Economy-First Paradigm in 'Sustainable Development' … 65 .... agreement, since such effective global cooperation on climate change ultimately ..... and foster innovation; reduce inequality within and among countries; make cities.

  10. Sustainable Soesterkwartier

    NARCIS (Netherlands)

    Abrahams, H.; Goosen, H.; Jong, de F.; Sickmann, J.; Prins, D.

    2010-01-01

    The municipality of Amersfoort wants to construct an endurable and sustainable eco-town in the Soesterkwartier neighbourhood, by taking future climate change into account. The impact of climate change at the location of the proposed eco-town was studied by a literature review.

  11. Factors Affecting Entrepreneurship and Business Sustainability

    Directory of Open Access Journals (Sweden)

    Ana Tur-Porcar

    2018-02-01

    Full Text Available Sustainability is becoming increasingly important for society, and the creation of business ventures is one area where sustainability is critical. We examined the factors affecting actions that are designed to foster business sustainability. These factors are related to the environment, behavior, human relations, and business activity. Based on questionnaire responses from experts, the Analytic Hierarchy Process (AHP method was used to rank sustainable business criteria according to their importance for entrepreneurs starting sustainable businesses. The results indicate that the most important drivers of sustainable entrepreneurship are behavioral factors and business factors. Ethical principles and values, together with competitive intelligence, are crucial for undertaking actions that lead to sustainability.

  12. Sustainable Sizing.

    Science.gov (United States)

    Robinette, Kathleen M; Veitch, Daisy

    2016-08-01

    To provide a review of sustainable sizing practices that reduce waste, increase sales, and simultaneously produce safer, better fitting, accommodating products. Sustainable sizing involves a set of methods good for both the environment (sustainable environment) and business (sustainable business). Sustainable sizing methods reduce (1) materials used, (2) the number of sizes or adjustments, and (3) the amount of product unsold or marked down for sale. This reduces waste and cost. The methods can also increase sales by fitting more people in the target market and produce happier, loyal customers with better fitting products. This is a mini-review of methods that result in more sustainable sizing practices. It also reviews and contrasts current statistical and modeling practices that lead to poor fit and sizing. Fit-mapping and the use of cases are two excellent methods suited for creating sustainable sizing, when real people (vs. virtual people) are used. These methods are described and reviewed. Evidence presented supports the view that virtual fitting with simulated people and products is not yet effective. Fit-mapping and cases with real people and actual products result in good design and products that are fit for person, fit for purpose, with good accommodation and comfortable, optimized sizing. While virtual models have been shown to be ineffective for predicting or representing fit, there is an opportunity to improve them by adding fit-mapping data to the models. This will require saving fit data, product data, anthropometry, and demographics in a standardized manner. For this success to extend to the wider design community, the development of a standardized method of data collection for fit-mapping with a globally shared fit-map database is needed. It will enable the world community to build knowledge of fit and accommodation and generate effective virtual fitting for the future. A standardized method of data collection that tests products' fit methodically

  13. Sustainable growth in Europe

    International Nuclear Information System (INIS)

    Andreini, P.

    1993-01-01

    The measures till now adopted did not stop environmental deterioration in Europe and the growth of economic activities in the future will make the situation more and more heavy. The European Communities (EEC) Cabinet launched a long term program for a sustainable growth in Europe, which could conciliate economic needs with environmental protection. This paper presents the first part of the program

  14. ANDRA - National Radioactive Waste Management Agency. Activity and sustainable development report 2010 - a year with Andra. Management report and financial statements 2010 - Managing today to prepare for tomorrow

    International Nuclear Information System (INIS)

    2011-01-01

    Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity and Sustainable Development Report, with the management and financial statements report, of the Andra for the year 2010

  15. Influence of sustained submaximal clenching fatigue test on electromyographic activity and maximum voluntary bite forces in healthy subjects and patients with temporomandibular disorders.

    Science.gov (United States)

    Xu, L; Fan, S; Cai, B; Fang, Z; Jiang, X

    2017-05-01

    This study aimed to investigate whether the fatigue induced by sustained motor task in the jaw elevator muscles differed between healthy subjects and patients with temporomandibular disorder (TMD). Fifteen patients with TMD and thirteen age- and sex-matched healthy controls performed a fatigue test consisting of sustained clenching contractions at 30% maximal voluntary clenching intensity until test failure (the criterion for terminating the fatigue test was when the biting force decreased by 10% or more from the target force consecutively for >3 s). The pre- and post-maximal bite forces (MBFs) were measured. Surface electromyographic signals were recorded from the superficial masseter muscles and anterior temporal muscles bilaterally, and the median frequency at the beginning, middle and end of the fatigue test was calculated. The duration of the fatigue test was also quantified. Both pre- and post-MBFs were lower in patients with TMD than in controls (P fatigue test in TMD patients was significantly shorter than that of the controls (P fatigued, but the electromyographic activation process during the fatigue test is similar between healthy subjects and patients with TMD. However, the mechanisms involved in this process remain unclear, and further research is warranted. © 2017 John Wiley & Sons Ltd.

  16. Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability from a nanoemulsion platform.

    Science.gov (United States)

    Choudhury, Hira; Gorain, Bapi; Karmakar, Sanmoy; Biswas, Easha; Dey, Goutam; Barik, Rajib; Mandal, Mahitosh; Pal, Tapan Kumar

    2014-01-02

    Paclitaxel, a potential anticancer agent against solid tumors has been restricted from its oral use due to poor water solubility as well as Pgp efflux property. The present study was aimed to improve the oral bioavailability of paclitaxel through development of (o/w) nanoemulsion consisting of Capryol 90 as internal phase with Tween 20 as emulsifier with water as an external phase. Formulations were selected from the nanoemulsion region of pseudo-ternary phase diagrams, formulated by aqueous titration method. The developed nanoemulsion has been characterized by its thermodynamic stability, morphology, droplet size, zeta potential, viscosity where in vitro release was evaluated through dialysis. Paclitaxel nanoemulsion exhibited thermodynamical stability with low viscosity, nano-sized oil droplets in water with low poly-dispersity index. The shelf life of the paclitaxel nanoemulsion was found to be approximately 2.38 years. Increased permeability through the Caco-2 cell monolayer and decreased efflux is great advantageous for nanoemulsion formulation. The effects of paclitaxel nanoemulsion on breast cancer cell proliferation, morphology and DNA fragmentation were analyzed in vitro which showed significant anti-proliferation and decreased IC50 values in nanoemulsion group which may be due to enhanced uptake of paclitaxel through the oil core. Moreover, the absolute oral bioavailability and sustained release profile of the paclitaxel nanoemulsion evaluated in mouse model was found to improve up to 55.9%. The concentration of paclitaxel in mice plasma was determined by our validated LC-MS/MS method. By reviewing the significant outcome of the present investigation based on stability study, Caco-2 permeability, cell proliferative assay and pharmacokinetic profile it may be concluded that the oral nanoemulsion has got encouraging advantages over the presently available formulations of this injectable chemotherapeutic drug. Copyright © 2013 Elsevier B.V. All rights

  17. Rab11 is phosphorylated by classical and novel protein kinase C isoenzymes upon sustained phorbol ester activation.

    Science.gov (United States)

    Pavarotti, Martín; Capmany, Anahí; Vitale, Nicolas; Colombo, María Isabel; Damiani, María Teresa

    2012-02-01

    Rab11 is a small GTPase that controls diverse intracellular trafficking pathways. However, the molecular machinery that regulates the participation of Rab11 in those different transport events is poorly understood. In resting cells, Rab11 localizes at the endocytic recycling compartment (ERC), whereas the different protein kinase C (PKC) isoforms display a cytosolic distribution. Sustained phorbol ester stimulation induces the translocation of the classical PKCα and PKCβII isoenzymes to the ERC enriched in Rab11, and results in transferrin recycling inhibition. In contrast, novel PKCε and atypical PKCζ isoenzymes neither redistribute to the perinucleus nor modify transferrin recycling transport after phorbol ester stimulation. Although several Rabs have been shown to be phosphorylated, there is to date no evidence indicating Rab11 as a kinase substrate. In this report, we show that Rab11 appears phosphorylated in vivo in phorbol ester-stimulated cells. A bioinformatic analysis of Rab11 allowed us to identify several high-probability Ser/Thr kinase phosphorylation sites. Our results demonstrate that classical PKC (PKCα and PKCβII but not PKCβI) directly phosphorylate Rab11 in vitro. In addition, novel PKCε and PKCη but not PKCδ isoenzymes also phosphorylate Rab11. Mass spectrometry analysis revealed that Ser 177 is the Rab11 residue to be phosphorylated in vitro by either PKCβII or PKCε. In agreement, the phosphomimetic mutant, Rab11 S177D, retains transferrin at the ERC in the absence of phorbol-12-myristate-13-acetate stimulus. This report shows for the first time that Rab11 is differentially phosphorylated by distinct PKC isoenzymes and that this post-translational modification might be a regulatory mechanism of intracellular trafficking. Copyright © 2012 Soçiété Francaise des Microscopies and Société de Biologie Cellulaire de France.

  18. Slovenian Mediterrananean and sustainable development

    Directory of Open Access Journals (Sweden)

    Mitja Bricelj

    2002-12-01

    Full Text Available Regional approach based on physical, social and economic characteristics of particular landscape what is basic input for sustainable development. The case Slovenian Mediterranean and sustainable development demonstrate public participation in the process of preparation of coastal management plan. For this process new forms of knowledge transfer to relevant public is needed to get their active position about different.

  19. Emergent pedagogy of sustainability

    DEFF Research Database (Denmark)

    Husted, Mia; Frøkjær, Thorleif

    of societal life. Most often, the experimental activities tends to favor learning about responsible behavior, but the intension was formation of critical curiosity. While the difficulties to find pedagogical forms to present sustainability frustrate the participating pedagogues, the teachers teaching student.......S. Nielsen, N. Sriskandarajah, & E. Gunnarsson (eds) (2016). Commons, Sustainability, Democratization: Action Research and the Basic Renewal of Society. New York. RoutledgeLewin, K. (1948). Resolving Social Conflicts. New York, Harper and RowSachs, W. (1999). Planet dialectics. Explorations in Environment...

  20. Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with Internet video game addiction.

    Science.gov (United States)

    Han, Doug Hyun; Hwang, Jun Won; Renshaw, Perry F

    2010-08-01

    Bupropion has been used in the treatment of patients with substance dependence based on its weak inhibition of dopamine and norepinephrine reuptake. We hypothesized that 6 weeks of bupropion sustained release (SR) treatment would decrease craving for Internet game play as well as video game cue-induced brain activity in patients with Internet video game addiction (IAG). Eleven subjects who met criteria for IAG, playing StarCraft (>30 hr/week), and eight healthy comparison subjects (HC) who had experience playing StarCraft (game, and the severity of Internet addiction were evaluated by Beck Depression Inventory, self-report of craving on a 7-point visual analogue scale, and Young's Internet Addiction Scale, respectively. In response to game cues, IAG showed higher brain activation in left occipital lobe cuneus, left dorsolateral prefrontal cortex, and left parahippocampal gyrus than HC. After a 6 week period of bupropion SR, craving for Internet video game play, total game play time, and cue-induced brain activity in dorsolateral prefrontal cortex were decreased in the IAG. We suggest that bupropion SR may change craving and brain activity in ways that are similar to those observed in individuals with substance abuse or dependence. PsycINFO Database Record 2010 APA, all rights reserved.

  1. The Trofobiose Theory and organic agriculture: the active mobilization of nutrients and the use of rock powder as a tool for sustainability

    Directory of Open Access Journals (Sweden)

    Wagner L. Polito

    2006-12-01

    Full Text Available The primary objective of the present paper is to link some relevant concepts on the use of ecological agricultural practices to the production of food crops. In a special topic the Trofobiose Theory, as well as the principle of Active Dissolution of Rocks are considered as important tools in improving the sustainability of Organic, Biodynamic and Process Agricultures.O objetivo principal deste trabalho é estabelecer relação entre alguns conceitos relevantes sobre o uso de práticas agro-ecológicas na produção de alimentos. Em um tópico especial, a Teoria da Trofobiose bem como os princípios da Dissolução Ativa de Rochas são considerados como importantes ferramentas na implementação da sustentabilidade no processo de Agriculturas Orgânica e Biodinâmica.

  2. Potential sustainable slow release fertilizers obtained by mechanochemical activation of layered double hydroxides and K{sub 2}HPO{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Borges, Roger; Wypych, Fernando, E-mail: 1roger.borges@gmail.com [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil); Prevot, Vanessa; Forano, Claude [Universite Blaise Pascal, Clermont-Ferrand (France)

    2016-07-01

    Full text: This study describes the preliminary results on the development of potential sustainable slow-release fertilizer (SSRF), obtained by mechanochemical activation of mixtures of calcined layered double hydroxides (LDH) Mg{sub 2}Al-CO{sub 3} and Mg{sub 2}Fe-CO{sub 3} and K{sub 2}HPO{sub 4}. The effect of LDH temperature of calcination, milling time (using a high-energy balls mill) and LDH:K{sub 2}HPO{sub 4} molar were investigated. The samples were characterized by XRD and FTIR. Phosphate release essays shown that its solubility is reduced, while the solubility of amorphous structures from LDH can be increased, which characterize the expected slow release behavior of a SSRF. (author)

  3. Specificities of sustainable tourism planning

    Directory of Open Access Journals (Sweden)

    Jegdić Vaso

    2013-01-01

    Full Text Available In the past two decades, companies have been mentioning achievement of sustainability in their activities as a target of companies, governments and non-profit organizations, although measuring the degree to which an organization conducts its activities in a sustainable manner, can be very difficult. Sustainable tourism development requires a process of planning and management that will unite the interests of various stakeholders in a sustainable and strategic way. It requires an understanding of the meaning of sustainable development and guiding values for promoting sustainable tourism. The paper points to the importance of cross-sector partnerships and the roles of different stakeholders in the planning of sustainable tourism projects. Special importance is given to the community of which a willingness to understand the impacts of tourism industry is expected, as well as various procedures of engagement in participatory planning, consensus building and conflict resolution among all stakeholders. The aim of this research is to find an optimal model of planning of sustainable tourism projects that would take into consideration the interests of all stakeholders and reflect the specificities imposed by the acceptance of the concept of sustainable development by all participants in the project.

  4. Sustainability in a global context: How does local factor affect the outcomes of CSR activities in international business units?

    DEFF Research Database (Denmark)

    Thomsen, Christa; Lauring, Jakob

    In recent years CSR has become increasingly important for the activities and branding of MNCs. While some studies have investigated CSR management and branding in domestic situations, fewer studies exist in the case of international business units (subsidiaries, joint ventures, and franchises...

  5. The induction of two biosynthetic enzymes helps Escherichia coli sustain heme synthesis and activate catalase during hydrogen peroxide stress.

    Science.gov (United States)

    Mancini, Stefano; Imlay, James A

    2015-05-01

    Hydrogen peroxide pervades many natural environments, including the phagosomes that mediate cell-based immunity. Transcriptomic analysis showed that during protracted low-grade H(2)O(2) stress, Escherichia coli responds by activating both the OxyR defensive regulon and the Fur iron-starvation response. OxyR induced synthesis of two members of the nine-step heme biosynthetic pathway: ferrochelatase (HemH) and an isozyme of coproporphyrinogen III oxidase (HemF). Mutations that blocked either adaptation caused the accumulation of porphyrin intermediates, inadequate activation of heme enzymes, low catalase activity, defective clearance of H(2)O(2) and a failure to grow. Genetic analysis indicated that HemH induction is needed to compensate for iron sequestration by the mini-ferritin Dps. Dps activity protects DNA and proteins by limiting Fenton chemistry, but it interferes with the ability of HemH to acquire the iron that it needs to complete heme synthesis. HemF is a manganoprotein that displaces HemN, an iron-sulfur enzyme whose synthesis and/or stability is apparently problematic during H(2)O(2) stress. Thus, the primary responses to H(2)O(2), including the sequestration of iron, require compensatory adjustments in the mechanisms of iron-cofactor synthesis. The results support the growing evidence that oxidative stress is primarily an iron pathology. © 2015 John Wiley & Sons Ltd.

  6. Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity

    Energy Technology Data Exchange (ETDEWEB)

    Hopperton, Kathryn E., E-mail: kathryn.hopperton@mail.utoronto.ca [Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 3E2 (Canada); Duncan, Robin E., E-mail: robin.duncan@uwaterloo.ca [Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 3E2 (Canada); Bazinet, Richard P., E-mail: richard.bazinet@utoronto.ca [Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 3E2 (Canada); Archer, Michael C., E-mail: m.archer@utoronto.ca [Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 3E2 (Canada); Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 3E2 (Canada)

    2014-01-15

    Fatty acid synthase is over-expressed in many cancers and its activity is required for cancer cell survival, but the role of endogenously synthesized fatty acids in cancer is unknown. It has been suggested that endogenous fatty acid synthesis is either needed to support the growth of rapidly dividing cells, or to maintain elevated glycolysis (the Warburg effect) that is characteristic of cancer cells. Here, we investigate both hypotheses. First, we compared utilization of fatty acids synthesized endogenously from {sup 14}C-labeled acetate to those supplied exogenously as {sup 14}C-labeled palmitate in the culture medium in human breast cancer (MCF-7 and MDA-MB-231) and untransformed breast epithelial cells (MCF-10A). We found that cancer cells do not produce fatty acids that are different from those derived from exogenous palmitate, that these fatty acids are esterified to the same lipid and phospholipid classes in the same proportions, and that their distribution within neutral lipids is not different from untransformed cells. These results suggest that endogenously synthesized fatty acids do not fulfill a specific function in cancer cells. Furthermore, we observed that cancer cells excrete endogenously synthesized fatty acids, suggesting that they are produced in excess of requirements. We next investigated whether lipogenic activity is involved in the maintenance of high glycolytic activity by culturing both cancer and non-transformed cells under anoxic conditions. Although anoxia increased glycolysis 2–3 fold, we observed no concomitant increase in lipogenesis. Our results indicate that breast cancer cells do not have a specific qualitative or quantitative requirement for endogenously synthesized fatty acids and that increased de novo lipogenesis is not required to sustain elevations in glycolytic activity induced by anoxia in these cells. - Highlights: • Fatty acid synthase (FASN) is over-expressed in cancer but its function is unknown. • We compare

  7. "Booster" interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods: internal pilot and feasibility study

    Directory of Open Access Journals (Sweden)

    Walters Stephen J

    2011-02-01

    Full Text Available Abstract Background Systematic reviews have identified a range of brief interventions which increase physical activity in previously sedentary people. A randomised controlled trial is needed to assess whether providing motivational interviewing, three months after giving initial advice, sustains physical activity levels in those who recently became physically active. This paper reports the results of an internal pilot study designed to test the feasibility of the study in terms of recruitment, per protocol delivery of the intervention and retention at three months. Methods Participants were: aged 40-64 years; resident in deprived areas of Sheffield, UK; and, had recently become physically active as a result of using a brief intervention following an invitation from a mass mailout. Interventions: Motivational Interviewing 'boosters' aimed at sustaining change in physical activity status delivered face-to-face or over the telephone compared with no further intervention. Outcomes of the feasibility study: recruitment of 60 participants from mailout of 3,300; retention of 45 participants with 3-month follow-up accelerometry measurements; 70% of those randomised to boosters receiving intervention per protocol. Sample size and power were recalculated using the accelerometry data collected. Results Forty-seven participants were randomised (78% of the feasibility target; 37 participants were retained at three months, 29 with at least four days of accelerometry data (64% of the feasibility target; 79% of those allocated boosters received them per protocol (surpassing the feasibility target. The proposed sample size of 600 was confirmed as appropriate and power is expected to be sufficient to detect a difference between groups. Conclusions The main study will continue with the original recruitment target of 600 participants but to ensure feasibility, it is necessary to increase recruitment and improve the numbers of those followed-up who have evaluable

  8. Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity

    International Nuclear Information System (INIS)

    Hopperton, Kathryn E.; Duncan, Robin E.; Bazinet, Richard P.; Archer, Michael C.

    2014-01-01

    Fatty acid synthase is over-expressed in many cancers and its activity is required for cancer cell survival, but the role of endogenously synthesized fatty acids in cancer is unknown. It has been suggested that endogenous fatty acid synthesis is either needed to support the growth of rapidly dividing cells, or to maintain elevated glycolysis (the Warburg effect) that is characteristic of cancer cells. Here, we investigate both hypotheses. First, we compared utilization of fatty acids synthesized endogenously from 14 C-labeled acetate to those supplied exogenously as 14 C-labeled palmitate in the culture medium in human breast cancer (MCF-7 and MDA-MB-231) and untransformed breast epithelial cells (MCF-10A). We found that cancer cells do not produce fatty acids that are different from those derived from exogenous palmitate, that these fatty acids are esterified to the same lipid and phospholipid classes in the same proportions, and that their distribution within neutral lipids is not different from untransformed cells. These results suggest that endogenously synthesized fatty acids do not fulfill a specific function in cancer cells. Furthermore, we observed that cancer cells excrete endogenously synthesized fatty acids, suggesting that they are produced in excess of requirements. We next investigated whether lipogenic activity is involved in the maintenance of high glycolytic activity by culturing both cancer and non-transformed cells under anoxic conditions. Although anoxia increased glycolysis 2–3 fold, we observed no concomitant increase in lipogenesis. Our results indicate that breast cancer cells do not have a specific qualitative or quantitative requirement for endogenously synthesized fatty acids and that increased de novo lipogenesis is not required to sustain elevations in glycolytic activity induced by anoxia in these cells. - Highlights: • Fatty acid synthase (FASN) is over-expressed in cancer but its function is unknown. • We compare utilization of

  9. Dynamics of renewable energy consumption and economic activities across the agriculture, industry, and service sectors: evidence in the perspective of sustainable development.

    Science.gov (United States)

    Paramati, Sudharshan Reddy; Apergis, Nicholas; Ummalla, Mallesh

    2018-01-01

    This study aims to examine the impact of renewable and non-renewable energy consumption on the agriculture, industry, services, and overall economic activities (GDP) across a panel of G20 nations. The study makes use of annual data from 1980 to 2012 on 17 countries of the G20. To achieve the study objectives, we apply several robust panel econometric models which account for cross-sectional dependence and heterogeneity in the analysis. The empirical findings confirm the significant long-run equilibrium relationship among the variables. The long-run elasticities indicate that both renewable and non-renewable energy consumptions have significant positive effect on the economic activities across the sectors and also on the overall economic output. These results also imply that the impact is more from renewable energy on economic activities than that of non-renewable energy. Given that, our results offer significant policy implications. We suggest that the policy makers should aim to initiate effective policies to turn domestic and foreign investments into renewable energy projects. This eventually ensures low carbon emissions and sustainable economic development across the G20 nations.

  10. HIV-1-negative female sex workers sustain high cervical IFNɛ, low immune activation, and low expression of HIV-1-required host genes.

    Science.gov (United States)

    Abdulhaqq, S A; Zorrilla, C; Kang, G; Yin, X; Tamayo, V; Seaton, K E; Joseph, J; Garced, S; Tomaras, G D; Linn, K A; Foulkes, A S; Azzoni, L; VerMilyea, M; Coutifaris, C; Kossenkov, A V; Showe, L; Kraiselburd, E N; Li, Q; Montaner, L J

    2016-07-01

    Sex workers practicing in high HIV endemic areas have been extensively targeted to test anti-HIV prophylactic strategies. We hypothesize that in women with high levels of genital exposure to semen changes in cervico-vaginal mucosal and/or systemic immune activation will contribute to a decreased susceptibility to HIV-1 infection. To address this question, we assessed sexual activity and immune activation status (in peripheral blood), as well as cellular infiltrates and gene expression in ectocervical mucosa biopsies in female sex workers (FSWs; n=50), as compared with control women (CG; n=32). FSWs had low-to-absent HIV-1-specific immune responses with significantly lower CD38 expression on circulating CD4(+) or CD8(+) T-cells (both: PHIV-1 integration and replication. A correlative relationship between semen exposure and elevated type-1 IFN expression in FSWs was also established. Overall, our data suggest that long-term condomless sex work can result in multiple changes within the cervico-vaginal compartment that would contribute to sustaining a lower susceptibility for HIV-1 infection in the absence of HIV-specific responses.

  11. Cardioprotective Action of Ginkgo biloba Extract against Sustained β-Adrenergic Stimulation Occurs via Activation of M2/NO Pathway

    Directory of Open Access Journals (Sweden)

    Thássio R. R. Mesquita

    2017-05-01

    Full Text Available Ginkgo biloba is the most popular phytotherapic agent used worldwide for treatment of several human disorders. However, the mechanisms involved in the protective actions of Ginkgo biloba on cardiovascular diseases remain poorly elucidated. Taking into account recent studies showing beneficial actions of cholinergic signaling in the heart and the cholinergic hypothesis of Ginkgo biloba-mediated neuroprotection, we aimed to investigate whether Ginkgo biloba extract (GBE promotes cardioprotection via activation of cholinergic signaling in a model of isoproterenol-induced cardiac hypertrophy. Here, we show that GBE treatment (100 mg/kg/day for 8 days, v.o. reestablished the autonomic imbalance and baroreflex dysfunction caused by chronic β-adrenergic receptor stimulation (β-AR, 4.5 mg/kg/day for 8 days, i.p.. Moreover, GBE prevented the upregulation of muscarinic receptors (M2 and downregulation of β1-AR in isoproterenol treated-hearts. Additionally, we demonstrated that GBE prevents the impaired endothelial nitric oxide synthase activity in the heart. GBE also prevented the pathological cardiac remodeling, electrocardiographic changes and impaired left ventricular contractility that are typical of cardiac hypertrophy. To further investigate the mechanisms involved in GBE cardioprotection in vivo, we performed in vitro studies. By using neonatal cardiomyocyte culture we demonstrated that the antihypertrophic action of GBE was fully abolished by muscarinic receptor antagonist or NOS inhibition. Altogether, our data support the notion that antihypertrophic effect of GBE occurs via activation of M2/NO pathway uncovering a new mechanism involved in the cardioprotective action of Ginkgo biloba.

  12. Quantitative sensory response of the SCM muscle on sustained low level activation simulating co-contractions during bruxing.

    Science.gov (United States)

    Eberhard, Lydia; Terebesi, Sophia; Giannakopoulos, Nikolaos Nikitas; Hellmann, Daniel; Schindler, Hans-Jürgen; Schmitter, Marc; Pfau, Doreen

    2018-02-01

    Bruxism is discussed as an etiological factor in the pathogenesis of orofacial and cervical pain. As the sternocleidomastoid muscle (SCM) is co-activated during clenching, our aim was to investigate, whether the muscle loading leads to peripheral or central sensitizations. In twenty-one healthy female volunteers, somatosensory profiles of the SCM were recorded according to the test battery of the German Research Network on Neuropathic Pain (DFNS) prior to and after an isometric muscle exercise. QST comprised thermal and mechanical stimuli. A submaximal activation of the SCM (15% MVC) was kept for 10min in sitting position. In separate test sessions one month apart, one sham and one verum experiment were conducted in randomized order. During the muscle loading, the parameters cold detection threshold (CDT), mechanical pain sensitivity (MPS) and pressure pain treshold (PPT) were tested and experimental pain recorded by visual analogoue scales (VAS). All test sessions were performed during the follicular phase of the menstrual cycle (day 5), to avoid effects on pain perception. Data were analyzed with Repeated Measures ANOVA (SPSS 22.0) RESULTS: No significant changes were found during or after (sham) loading except for stimulus-response-function (SR, P=0.01) and PPT (P=0.02) in the sham test. No effect was observed in the verum experiment (P=0.12 up to 1.0). Prolonged low level contraction of the SCM does not evoke painful sensitization. In contrast, submaximal muscle activation seems to have a protective effect corresponding to a training effect preventing sensitization. Copyright © 2017. Published by Elsevier Ltd.

  13. Building sustainability

    CSIR Research Space (South Africa)

    Mass Media

    2007-11-01

    Full Text Available particu- lar social environment also being awarded. If a building can be used by the community after hours, it should be awarded extra points.” School sports facilities or meeting halls in corporate buildings, are some example. Multi-purpose use..., architect and senior researcher for the CSIR’s Built Environment Unit, the integra- tion of sustainability in building design cannot begin soon enough before it is too late. He says: “Unfortunately nothing is in place in South Africa. For a start...

  14. Community Development to Feed the Family in Northern Manitoba Communities: Evaluating Food Activities based on Their Food Sovereighnty, Food Security, and Sustainable Livelihood Outcomes

    Directory of Open Access Journals (Sweden)

    Mohammad Ashraful Alam

    2012-12-01

    Full Text Available This article explores food-related activities and their impacts on sustainable livelihood assets, food sovereignty, and food security, and provides insight for future food-related community development. Analysis is based on community food assessments conducted in 14 Northern Manitoba communities and included a food security survey, price survey, and interviews. The lack of community control over development in First Nation and other Northern remote and rural communities in Northern Manitoba is found to undermine both food sovereignty and sustainable livelihoods, while creating high levels of food insecurity. According to logit models, sharing country foods increases food sovereignty and sustainable livelihoods, and has a stronger relationship to food security than either road access to retail stores in urban centres or increased competition between stores. The model predicts that rates of food insecurity for a community with a country foods program and with access to public transit and roads at 95% would be lower than the Canadian average of 92%.RÉSUMÉCet article explore les activités relatives à l’alimentation et leur impact sur les biens durables ainsi que sur la souveraineté et la sécurité alimentaires tout en ouvrant des perspectives sur le développement communautaire futur relatif à l’alimentation. L’analyse se fonde sur une recherche menée dans quatorze communautés du nord du Manitoba et comprend un premier sondage sur la sécurité alimentaire, un second sondage sur les prix, et des entrevues. Le manque de contrôle du développement dans les communautés reculées du nord du Manitoba, tant autochtones que non-autochtones, mine à la fois la souveraineté alimentaire et les moyens d’existence durables tout en provoquant de hauts niveaux d’insécurité alimentaire. Selon un modèle Logit, le partage d’aliments locaux permet une souveraineté alimentaire et une autonomie durable tout en ayant un meilleur impact sur la

  15. Report on childhood obesity in China (8): effects and sustainability of physical activity intervention on body composition of Chinese youth.

    Science.gov (United States)

    Li, Yan-Ping; Hu, Xiao-Qi; Schouten, Evert G; Liu, Ai-Ling; Du, Song-Ming; Li, Lin-Zhong; Cui, Zhao-Hui; Wang, Dong; Kok, Frans J; Hu, Frank B; Ma, Guan-Sheng

    2010-06-01

    To determine whether a large-scale physical activity intervention could affect body composition in primary school students in Beijing, China. The study design was one-year cluster randomized controlled trial of physical activity intervention (20 min of daily exercise in the classroom) with an additional year of follow-up among 4 700 students aged 8-11 years at baseline. After the one-year intervention, BMI increased by 0.56 kg/m(2) (SD 1.15) in the intervention group and by 0.72 kg/m(2) (SD 1.20) in the control group, with a mean difference of -0.15 kg/m(2) (95% CI: -0.28 to -0.02). BMI z score decreased by -0.05 (SD 0.44) in the intervention group, but increased by 0.01 (SD 0.46) in the control group, with a mean difference of -0.07 (-0.13 to -0.01). After another year of follow up, compared to the control group, children in the intervention group had significantly lower BMI (-0.13, -0.25 to -0.01), BMI z score (-0.05, -0.10 to -0.01), fat mass (-0.27 kg, -0.53 to -0.02) and percent body fat (-0.53, -1.00 to -0.05). The intervention had a more pronounced effect on weight, height, BMI, BMI z score, and body composition among obese children than among normal weight or overweight children. Compared to the control group, the intervention group had a significantly higher percentage of children who maintained or reduced their BMI z score at year 1 (P=0.008) and year 2 (P=0.04). These findings suggest that 20 min of daily moderate to vigorous physical activity during the school year is a feasible and effective way to prevent excessive gain of body weight, BMI, and body fatness in primary school students. Copyright © 2010 The Editorial Board of Biomedical and Environmental Sciences. Published by Elsevier B.V. All rights reserved.

  16. Status of Activities to Implement a Sustainable System of MC and A Equipment and Methodological Support at Rosatom Facilities

    International Nuclear Information System (INIS)

    Sanders, J.D.

    2010-01-01

    Under the U.S.-Russian Material Protection, Control and Accounting (MPC and A) Program, the Material Control and Accounting Measurements (MCAM) Project has supported a joint U.S.-Russian effort to coordinate improvements of the Russian MC and A measurement system. These efforts have resulted in the development of a MC and A Equipment and Methodological Support (MEMS) Strategic Plan (SP), developed by the Russian MEM Working Group. The MEMS SP covers implementation of MC and A measurement equipment, as well as the development, attestation and implementation of measurement methodologies and reference materials at the facility and industry levels. This paper provides an overview of the activities conducted under the MEMS SP, as well as a status on current efforts to develop reference materials, implement destructive and nondestructive assay measurement methodologies, and implement sample exchange, scrap and holdup measurement programs across Russian nuclear facilities.

  17. Status of Activities to Implement a Sustainable System of MC&A Equipment and Methodological Support at Rosatom Facilities

    Energy Technology Data Exchange (ETDEWEB)

    J.D. Sanders

    2010-07-01

    Under the U.S.-Russian Material Protection, Control and Accounting (MPC&A) Program, the Material Control and Accounting Measurements (MCAM) Project has supported a joint U.S.-Russian effort to coordinate improvements of the Russian MC&A measurement system. These efforts have resulted in the development of a MC&A Equipment and Methodological Support (MEMS) Strategic Plan (SP), developed by the Russian MEM Working Group. The MEMS SP covers implementation of MC&A measurement equipment, as well as the development, attestation and implementation of measurement methodologies and reference materials at the facility and industry levels. This paper provides an overview of the activities conducted under the MEMS SP, as well as a status on current efforts to develop reference materials, implement destructive and nondestructive assay measurement methodologies, and implement sample exchange, scrap and holdup measurement programs across Russian nuclear facilities.

  18. Orofacial muscular activity and related skin movement during the preparatory and sustained phases of tone production on the French horn.

    Science.gov (United States)

    Hirano, Takeshi; Kudo, Kazutoshi; Ohtsuki, Tatsuyuki; Kinoshita, Hiroshi

    2013-07-01

    This study investigated activity of the embouchure-related orofacial muscles during pre- and postattack phases of sound production by 10 trained French-horn players. Surface electromyogram (EMG) from five selected facial muscles, and related facial skin kinematics were examined in relation to pitch and intensity of a tone produced. No difference in EMGs and facial kinematics between the two phases was found, indicating importance of appropriate formation of preattack embouchure. EMGs in all muscles during the postattack phase increased linearly with an increase in pitch, and they also increased with tone intensity without interacting with the pitch effect. Orofacial skin movement remained constant across all pitches and intensities except for lateral retraction of the lips during high-pitch tone production. Contraction of the orofacial muscles is fundamentally isometric by which tension on the lips and the cheeks is regulated for flexible sound parameter control.

  19. Sustained effects of volcanic ash on biofilm stoichiometry, enzyme activity and community composition in North- Patagonia streams.

    Science.gov (United States)

    Carrillo, Uara; Díaz-Villanueva, Verónica; Modenutti, Beatriz

    2018-04-15

    Volcanic eruptions are extreme perturbations that affect ecosystems. These events can also produce persistent effects in the environment for several years after the eruption, with increased concentrations of suspended particles and the introduction of elements in the water column. On 4th June 2011, the Puyehue-Cordón Caulle Volcanic Complex (40.59°S-72.11°W, 2200m.a.s.l.) erupted explosively in southern Chile. The area affected by the volcano was devastated; a thick layer of volcanic ash (up to 30cm) was deposited in areas 50 km east of the volcano towards Argentina. The aim of the present study was to evaluate the effect of volcanic ash deposits on stream ecosystems four years after the eruption, comparing biofilm stoichiometry, alkaline phosphatase activity, and primary producer's assemblage in streams which were severely affected by the volcano with unaffected streams. We confirmed in the laboratory that ash deposited in the catchment of affected streams still leach phosphorus (P) into the water four years after eruption. Results indicate that affected streams still receive volcanic particles and that these particles release P, thus stream water exhibits high P concentration. Biofilm P content was higher and the C:P ratio lower in affected streams compared to unaffected streams. As a consequence of less P in unaffected streams, the alkaline phosphatase activity was higher compared to affected streams. Cyanobacteria increased their abundances (99.9% of total algal biovolume) in the affected streams suggesting that the increase in P may positively affect this group. On the contrary, unaffected streams contained a diatom dominant biofilm. In this way, local heterogeneity was created between sub-catchments located within 30 km of each other. These types of events should be seen as opportunities to gather valuable ecological information about how severe disturbances, like volcanic eruptions, shape landscapes and lotic systems for several years after the event

  20. Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity.

    Science.gov (United States)

    Hopperton, Kathryn E; Duncan, Robin E; Bazinet, Richard P; Archer, Michael C

    2014-01-15

    Fatty acid synthase is over-expressed in many cancers and its activity is required for cancer cell survival, but the role of endogenously synthesized fatty acids in cancer is unknown. It has been suggested that endogenous fatty acid synthesis is either needed to support the growth of rapidly dividing cells, or to maintain elevated glycolysis (the Warburg effect) that is characteristic of cancer cells. Here, we investigate both hypotheses. First, we compared utilization of fatty acids synthesized endogenously from (14)C-labeled acetate to those supplied exogenously as (14)C-labeled palmitate in the culture medium in human breast cancer (MCF-7 and MDA-MB-231) and untransformed breast epithelial cells (MCF-10A). We found that cancer cells do not produce fatty acids that are different from those derived from exogenous palmitate, that these fatty acids are esterified to the same lipid and phospholipid classes in the same proportions, and that their distribution within neutral lipids is not different from untransformed cells. These results suggest that endogenously synthesized fatty acids do not fulfill a specific function in cancer cells. Furthermore, we observed that cancer cells excrete endogenously synthesized fatty acids, suggesting that they are produced in excess of requirements. We next investigated whether lipogenic activity is involved in the maintenance of high glycolytic activity by culturing both cancer and non-transformed cells under anoxic conditions. Although anoxia increased glycolysis 2-3 fold, we observed no concomitant increase in lipogenesis. Our results indicate that breast cancer cells do not have a specific qualitative or quantitative requirement for endogenously synthesized fatty acids and that increased de novo lipogenesis is not required to sustain elevations in glycolytic activity induced by anoxia in these cells. © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

  1. Neutron activation and atomic absorption analyses of heavy metals in corals of Malaysia: historical recorders for sustainable environmental management

    International Nuclear Information System (INIS)

    Mazlin Mokhtar; Almah Awaludin; Abdul Khalik Wood; Lim Kim Shenk; Tan Pey Fang; Yasmin Mohd Hasni

    2001-01-01

    This paper reports the determination of total chromium (Cr), manganese (Mn), and zinc (Zn) in skeletons of the corals Porites sp., sediment and sea water samples taken from various locations in waters of Kedah, Johor and Labuan. Sampling was carried out around Pulau Bunting, Pulau Bidan, Pulau Telur, Pulau Songsong, all in Kedah, Pulau Burung in Labuan, and Pulau Lima in Johor. The concentrations of metals were determined using neutron activation analysis (NAA) and atomic absorption spectrophotometry (AAS). The range of concentrations of Cr, Mn and Zn in coral samples of this study were <0.2 - 1.60, 1.20 - 11.10 and 3.55 - 15.08 μg/g, respectively. Concentrations in sediment samples were Cr 0.62 - 5.19 μg/g, Mn 71.0 - 162 μg/g and Zn 28.2 - 57.8 μg/g. The levels in seawater samples were Cr 0.004 - 0.28 mg/l, Mn 0.26 - 0.33 mg/l, and Zn 0.92 - 1.56 mg/l. (Author)

  2. A comparative study on the properties of graphene oxide and activated carbon based sustainable wood starch composites.

    Science.gov (United States)

    Baishya, Prasanta; Maji, Tarun Kumar

    2018-08-01

    Activated carbon (AC) prepared from Jatropha curcas and graphene oxide (GO) were employed in the preparation of natural polymer based wood starch composites (WSC) through the solution blending technique using water as a solvent. In this study, methyl methacrylate (MMA) was grafted onto the starch polymer and this MMA grafted starch (MMA-g-starch) was cross-linked with the cheap soft wood flour using the citric acid as cross-linker and water as a solvent in the whole process. The prepared GO and AC were characterized through Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), thermogravimetric analysis (TGA) and Raman study. The interaction of GO and AC, with MMA-g-starch, citric acid and wood were studied by FTIR, XRD and SEM analysis. The GO and AC treated composites exhibited outstanding mechanical properties, thermal stability and fire resistance properties. The tensile strength of the composites increased by 178% and 200% with addition of 2 phr AC and GO respectively compared to untreated composites. A significant enhancement in water resistance properties of GO and AC treated composites was also attained. The study showed that the properties of the composites containing AC prepared from the seeds of Jatropha curcas was quite comparable with the composites reinforced with GO. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. NASA Ames Environmental Sustainability Report 2011

    Science.gov (United States)

    Clarke, Ann H.

    2011-01-01

    The 2011 Ames Environmental Sustainability Report is the second in a series of reports describing the steps NASA Ames Research Center has taken toward assuring environmental sustainability in NASA Ames programs, projects, and activities. The Report highlights Center contributions toward meeting the Agency-wide goals under the 2011 NASA Strategic Sustainability Performance Program.

  4. Interdependences between sustainable development and sustainable economy

    OpenAIRE

    Emilia Mioara CÂMPEANU; Carmen Valentina RĂDULESCU

    2014-01-01

    Sustainable development and sustainable economy are mostly used concepts. Understanding clearly their meaning allows their use in an appropriate context and, therefore, their boundaries in terms of theoretical and practical approaches on which occasion it can be given their interdependencies. The paper aim is to analyze the interdependences between sustainable development and sustainable economy.

  5. Towards sustainable food production

    DEFF Research Database (Denmark)

    Aramyan, Lusine H; Hoste, Robert; van den Broek, Willie

    2011-01-01

    continuous innovation of supply chain network structures, reconsideration of business processes, relocation of logistics infrastructures and renewed allocation of chain activities to these infrastructures in order to achieve sustainable performances. This paper presents a scenario analysis of the spatial...... of pigs, processing of pork and pork consumption, is used to analyse the scenarios. The results reveal major opportunities for reductions in cost as well as in CO2 equivalent emissions if a European sector perspective is taken and some chain activities are relocated to other countries. However......, as minimizing costs will not always lead to an optimal reduction in CO2 equivalent emissions, a differentiated strategy is needed for the European pork sector to move towards more sustainable production...

  6. Sustained participation in annual continuous quality improvement activities improves quality of care for Aboriginal and Torres Strait Islander children.

    Science.gov (United States)

    McAullay, Daniel; McAuley, Kimberley; Bailie, Ross; Mathews, Veronica; Jacoby, Peter; Gardner, Karen; Sibthorpe, Beverly; Strobel, Natalie; Edmond, Karen

    2018-02-01

    To determine whether participation in the continuous quality improvement (CQI) Audit and Best Practice for Chronic Disease programme improved care and outcomes for Indigenous children. Data were collected from 59 Australian primary health-care centres providing services to Indigenous people and participating in the programme (February 2008 and December 2013). Indigenous children aged less than 2 years and centres that completed three or more consecutive annual audits within the 6-year study period were included. Crude and adjusted logistic generalised estimating equation models were used to examine the effect of year of audit on the delivery of care. Odds ratio (OR) and 95% confidence interval (CI) were calculated. Outcomes were related to age-relevant health issues, including prevention and early intervention. These included administrative, health check, anticipatory guidance and specific health issues. During the audit period, there were 2360 files from 59 centres. Those that had a recall recorded, improved from 84 to 95% (OR 2.44, 95% CI 1.44-4.11). Hearing assessments improved from 52 to 89% (OR 1.37, 95% CI 1.22-1.54). Improvement in anticipatory guidance, treatment and follow-up of medical conditions was almost universal. We documented significant improvements in quality of care of Indigenous children. Outcomes and their corresponding treatment and follow-ups improved over time. This appears to be related to services participating in annual CQI activities. However, these services may be more committed to CQI than others and therefore possibly better performing. © 2017 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

  7. Virtual Sustainability

    Directory of Open Access Journals (Sweden)

    William Sims Bainbridge

    2010-09-01

    Full Text Available In four ways, massively multiplayer online role-playing games may serve as tools for advancing sustainability goals, and as laboratories for developing alternatives to current social arrangements that have implications for the natural environment. First, by moving conspicuous consumption and other usually costly status competitions into virtual environments, these virtual worlds might reduce the need for physical resources. Second, they provide training that could prepare individuals to be teleworkers, and develop or demonstrate methods for using information technology to replace much transportation technology, notably in commuting. Third, virtual worlds and online games build international cooperation, even blending national cultures, thereby inching us toward not only the world consciousness needed for international agreements about the environment, but also toward non-spatial government that cuts across archaic nationalisms. Finally, realizing the potential social benefits of this new technology may urge us to reconsider a number of traditional societal institutions.

  8. Sustainability Assessment and Reporting in Agriculture Sector

    OpenAIRE

    Edward Kassem; Oldřich Trenz; Jiří Hřebíček; Oldřich Faldík

    2017-01-01

    Sustainability assessment is a mainstream business activity that demonstrates the link between the organization’s strategy and commitment to a sustainable global economy. Sustainability indicators describe the environmental, social, economic and governance performance of Small and Medium‑sized Businesses/Enterprises (SMB/SME). Unfortunately, their implementations in the Czech Republic show a low level of engagement in sustainability assessment. The paper presents the results of the authors’ r...

  9. Sustainable mining management

    International Nuclear Information System (INIS)

    Tejera Oliver, J. L.

    2009-01-01

    Mining activities are carried out by the older man and have provided resources, since ancient times, for their development and progress. With the discovery of fire will show the first metals that have marked the civilizations of copper, bronze and iron, and is the prehistory of the Stone Age tools that man has made from the exploitation of quarries first. The industrial revolution of the nineteenth century is linked to coal and steel, and could not conceiver of todays society without oil and gas, without silicon and coltan. But the mines are often aggressive and, despite their need and what they contribute to the development are answered by the societies where are made. during recent years there has been growing international efforts to try to make the minimum requirements of sustainable exploitation (European Directives, GMI, GRI, etc.) In AENOR, and within the Technical Committee of Standardization 22 Mining and Explosives, chaired by AITEMIN, was established the subcommittee 3, chaired by IGME, where, with the participation of all stake holders, have developed some standards on sustainable mining management sustainable mining that will be a tool available to mining companies to demonstrate their sustainable use to Society. (Author)

  10. Impacts of Agricultural Practices and Tourism Activities on the Sustainability of Telaga Warna and Telaga Pengilon Lakes, Dieng Plateau, Central Java

    Science.gov (United States)

    Sudarmadji; Pudjiastuti, Hermin

    2018-02-01

    Telaga Warna and Telaga Pengilon are two volcanic lakes in the Dieng Plateau offer some unique phenomena which are interested for tourists to visit. Telaga Warna and Telaga Pengilon are located side by side in the Dieng Palteau. Those two lakes also have specific ecosystem which differ to other lakes. However as land use in the surrounding area is now gradually changing, the lake is now facing to environmental degradation. The land use in the surrounding area is for intensive agricultural which main crops are vegetable, especially potatoes. Meanwhile, the number of tourist visiting those two lakes is increasing; it may also give some impact to the lake environment. This research aims to study the impacts of agricultural practices and tourism activities to the lake environmental which lead to the environment sustainability of the lakes. The field survey was conducted to collect some data on lakes characteristics, agricultural and tourism activities. Some interviews to local people and tourists were also conducted. Some water and sediment samples were collected followed by laboratory analyses. Some secondary data from previous study was also collected. Data analysis was conducted based on qualitative and quantitative techniques. The study found that agricultural practices of potatoes plantation uses water from the Telaga Pengilon to irrigate the plant by pumping out the water using water pump and distributes the water over the plantation area. Agricultural practices lead to soil erosion, which contribute sediment to the lake carried by surface runoff. Therefore, the volume of lakes is gradually decreasing. The use of fertilizer in the agricultural practice contribute nutrient into the lake carried by surface runoff, leading to the eutrophication, due to the excess used of fertilizer. The study concludes that agricultural practices and tourism activities have some positive economic impacts to the local community, however it also give some adverse affects on the lakes

  11. Using the Program Sustainability Assessment Tool to Assess and Plan for Sustainability

    Science.gov (United States)

    Mainor, Avia; Moreland-Russell, Sarah; Maier, Ryan C.; Brossart, Laura; Luke, Douglas A.

    2014-01-01

    Implementing and growing a public health program that benefits society takes considerable time and effort. To ensure that positive outcomes are maintained over time, program managers and stakeholders should plan and implement activities to build sustainability capacity within their programs. We describe a 3-part sustainability planning process that programs can follow to build their sustainability capacity. First, program staff and stakeholders take the Program Sustainability Assessment Tool to measure their program’s sustainability across 8 domains. Next, managers and stakeholders use results from the assessment to inform and prioritize sustainability action planning. Lastly, staff members implement the plan and keep track of progress toward their sustainability goals. Through this process, staff can more holistically address the internal and external challenges and pressures associated with sustaining a program. We include a case example of a chronic disease program that completed the Program Sustainability Assessment Tool and engaged in program sustainability planning. PMID:24456644

  12. Specific and Nonspecific Neural Activity during Selective Processing of Visual Representations in Working Memory

    Science.gov (United States)

    Oh, Hwamee; Leung, Hoi-Chung

    2010-01-01

    In this fMRI study, we investigated prefrontal cortex (PFC) and visual association regions during selective information processing. We recorded behavioral responses and neural activity during a delayed recognition task with a cue presented during the delay period. A specific cue ("Face" or "Scene") was used to indicate which one of the two…

  13. Sustained disease-activity-free status in patients with relapsing-remitting multiple sclerosis treated with cladribine tablets in the CLARITY study: a post-hoc and subgroup analysis

    DEFF Research Database (Denmark)

    Giovannoni, Gavin; Cook, Stuart; Rammohan, Kottil

    2011-01-01

    /kg over 96 weeks was more effective than placebo. Achieving sustained freedom from disease activity is becoming a viable treatment goal in RRMS; we therefore aimed to assess the effects of cladribine on this composite outcome measure by doing a post-hoc analysis of data from the CLARITY study....

  14. Y-12 Site Sustainability Plan

    Energy Technology Data Exchange (ETDEWEB)

    Sherry, T D; Kohlhorst, D P; Little, S K

    2011-12-01

    The accomplishments to date and the long-range planning of the Y-12 Energy Management and Sustainability and Stewardship programs support the DOE and the National Nuclear Security Administration (NNSA) vision for a commitment to energy efficiency and sustainability and to achievement of the Guiding Principles. Specifically, the Y-12 vision is to support the Environment, Safety and Health Policy and the DOE Strategic Sustainability Performance Plan (SSPP) while promoting overall sustainability and reduction of greenhouse gas (GHG) emissions. Table ES.2 gives a comprehensive overview of Y-12's performance status and planned actions. B&W Y-12's Energy Management mission is to incorporate renewable energy and energy efficient technologies site-wide and to position Y-12 to meet NNSA energy requirement needs through 2025 and beyond. During FY 2011, the site formed a sustainability team (Fig. ES.1). The sustainability team provides a coordinated approach to meeting the various sustainability requirements and serves as a forum for increased communication and consistent implementation of sustainability activities at Y-12. The sustainability team serves as an information exchange mechanism to promote general awareness of sustainability information, while providing a system to document progress and to identify resources. These resources are necessary to implement activities that support the overall goals of sustainability, including reducing the use of resources and conserving energy. Additionally, the team's objectives include: (1) Foster a Y-12-wide philosophy to conserve resources; (2) Reduce the impacts of production operations in a cost-effective manner; (3) Increase materials recycling; (4) Use a minimum amount of energy and fuel; (5) Create a minimum of waste and pollution in achieving Y-12-strategic objectives; (6) Develop and implement techniques, technologies, process modifications, and programs that support sustainable acquisition; (7) Minimize the

  15. SUSTAINABLE AND DESIGN BUILDING PROCESSES

    Directory of Open Access Journals (Sweden)

    Silvio F. R. MOTTA

    2009-05-01

    Full Text Available The article presents a historical revision of the sustainable development and the sustainable in the constructed environment. It describes the main concepts and practices for implantation of the sustainable in the civil construction. These concepts and practices are reviewed from the perspective of the dialectic method, the general theory of systems and the theories of creative processes. These concepts are also analyzed from the perspective of quality management. The article proposes a model based on the dialectic, in which sustainability is considered an open system and a search inventive. The implantation of the sustainable in projects, companies and design processes are considered as main strategy. A vertical insertion of the sustainable in the process is proposal. In this vertical insertion, the sustainable is presents in all the phases and activities of the process. The model is organized to promote the external creative solutions to the process, through the promotion of research centers. Tools of selection of possibilities and practical are suggested, considering the characteristic dialectics proposals. The article concludes that sustainable is a cultural change in the processes, practical and management current.

  16. International Atomic Energy Agency Activities on Education and Training in Radiation Transport and Waste Safety: Strategic Approach for a Sustainable System

    International Nuclear Information System (INIS)

    Mrabit, K.; Sadagopan, G.

    2004-01-01

    The statutory safety functions of the International Atomic Energy Agency (IAEA) include the establishment of and provision for the application of safety standards for protection of health, life and property against ionizing radiation. The safety standards are based on the presumption that a national infrastructure is in place enabling the Government to discharge its responsibilities for protection and safety. Education and training is an essential element of the infrastructure. The IAEA education and training activities follows the resolutions of its General Conferences and reflects the latest IAEA standards and guidance. Several General Conference resolutions have emphasized the importance of education and training [e.g. GC(XXXV)/RES/552 in 1991; GC(XXXVI)/RES/584 in 1992; GC(43)/RES/13 in 1999 and more recently GC(44)/RES/13 in 2000]. In response to GC(44)/RES/13, the IAEA prepared a S trategic Approach to Education and Training in Radiation and Waste Safety ( Strategy on Education and Training) aiming at establishing, by 2010, sustainable education and training programmes in Member States. This Strategy was endorsed by the General Conference resolution GC(45)/RES/10C that, inter alia, urged the Secretariat to implement the Strategy on Education and Training, and to continue to strengthen, subject to available resources, its current effort in this area, and in particular to assist Member State' national, regional and collaborating centres in conducting such education and training activities in the relevant official languages of the IAEA. The General Conference resolutions GC(46)RES/9C in 2002 and GC(47)RES/7 in 2003 urged the Agency to continue its efforts to implement the Strategy. The purpose of this paper is to present the newly established Strategic Approach to Education and Training in Radiation, Transport and Waste Safety and its implementation. (Author)

  17. Inactivation of uptake hydrogenase leads to enhanced and sustained hydrogen production with high nitrogenase activity under high light exposure in the cyanobacterium Anabaena siamensis TISTR 8012

    Directory of Open Access Journals (Sweden)

    Khetkorn Wanthanee

    2012-10-01

    Full Text Available Abstract Background Biohydrogen from cyanobacteria has attracted public interest due to its potential as a renewable energy carrier produced from solar energy and water. Anabaena siamensis TISTR 8012, a novel strain isolated from rice paddy field in Thailand, has been identified as a promising cyanobacterial strain for use as a high-yield hydrogen producer attributed to the activities of two enzymes, nitrogenase and bidirectional hydrogenase. One main obstacle for high hydrogen production by A. siamensis is a light-driven hydrogen consumption catalyzed by the uptake hydrogenase. To overcome this and in order to enhance the potential for nitrogenase based hydrogen production, we engineered a hydrogen uptake deficient strain by interrupting hupS encoding the small subunit of the uptake hydrogenase. Results An engineered strain lacking a functional uptake hydrogenase (∆hupS produced about 4-folds more hydrogen than the wild type strain. Moreover, the ∆hupS strain showed long term, sustained hydrogen production under light exposure with 2–3 folds higher nitrogenase activity compared to the wild type. In addition, HupS inactivation had no major effects on cell growth and heterocyst differentiation. Gene expression analysis using RT-PCR indicates that electrons and ATP molecules required for hydrogen production in the ∆hupS strain may be obtained from the electron transport chain associated with the photosynthetic oxidation of water in the vegetative cells. The ∆hupS strain was found to compete well with the wild type up to 50 h in a mixed culture, thereafter the wild type started to grow on the relative expense of the ∆hupS strain. Conclusions Inactivation of hupS is an effective strategy for improving biohydrogen production, in rates and specifically in total yield, in nitrogen-fixing cultures of the cyanobacterium Anabaena siamensis TISTR 8012.

  18. International Atomic Energy Agency Activities on Education and Training in Radiation, Transport and Waste Safety: Strategic Approach for a Sustainable System

    International Nuclear Information System (INIS)

    Marbit, K.; Sadagopan, G.

    2005-01-01

    The statutory safety functions of the international Atomic Energy Agency (IAEA) include the establishment of and provision for the application of safety standards for protection of health, life and property against ionizing radiation. The safety standards are based on the presumption that a national infrastructure is in place enabling the government to discharge its responsibilities for protection and safety. Education and training is an essential element of the infrastructure. The IAEA education and training activities follows the the resolutions of its general conferences and reflects the latest IAEA standards and guidance. several general conference resolutions have emphasized the importance of education and training (e.g. GC (XXXV)/RES/552 in 1991,GC (XXXVI)/ RES/584 in 1992, GC (43)/RES/13 in 1999 and more recently GC (44)/RES/13 in 2000). In response to GC (44) /RES/13, the IAEA prepared a strategic approach to education and training in radiation and waste safety (strategy on education and training) aiming at establishing, by 2010 sustainable education and training programmes in member states. This strategy was endorsed by the general conference resolution GC(45)/RES/10C that, inter alia, urged the secretariat to implement the strategy on education and training, and to continue to strengthen, subject to available resources, its current effort in this area, and in particular to assist Member States national, regional and collaborating centres in conducting such education and training activities in the relevant official languages of the IAEA. The General Conference resolutions GC(46)RES/9C in 2002 and GC(47)RES/7 in 2003 urged the Agency to continue its efforts to implement the Strategy. The purpose of this paper is to present the newly established Strategic Approach to Education and Training in Radiation, Transport and Waste Safety and its implementation

  19. Responsible marketing for sustainable tourism

    OpenAIRE

    Jegdić Vaso

    2014-01-01

    The biggest challenge associated with the concept of sustainable tourism is its operationalisation and perception as a process to be applied through development plans, projects and ongoing activities of tour operators. The traditional approach to marketing, focused on a limited idea of maximising profit businesses, was not able to respond to a number of social and environmental requirements imposed by the concept of sustainable development. This paper discusses the ways in which marketing cou...

  20. Property company's sustainability goals.

    Science.gov (United States)

    Ormsby, Kim

    2014-11-01

    In a keynote presentation on the second morning of this year's Healthcare Estates conference, Kim Ormsby (pictured), national corporate social responsibility (CSR) and sustainability manager at NHS Property Services, discussed how, as part of its broader goals of 'supporting the NHS in delivering clinical services', and 'helping to enhance the experience' of patients visiting its buildings, the organization would continue to pursue and embed in its activities sustainable policies wherever and whenever possible, encouraging both its staff and tenants to take a similar approach. In an informative address, she highlighted some of the key steps the property company had already taken to encourage a proactive approach. Echoing the sentiments of Day One keynote speaker, Julian Hartley (see pages 55-60), she argued that one of the fundamentals to success was wide-ranging staff engagement.

  1. Sustainability and specialisation

    Directory of Open Access Journals (Sweden)

    John Cairns Jr.

    2004-05-01

    Full Text Available Society depends heavily on its major universities and independent research organisations for new ideas. Arguable, sustainable use of the planet will require conceptual paradigms unprecedented in human history. Educational systems, especially major universities and research organisations, must produce students in all phases of the educational continuum who are capable of transdisciplinary activities. A much larger group of such students will be required to implement these new undertakings. Until the perception of the need for transdisciplinary education becomes widespread, nothing significant is likely to happen. One major obstacle is the lack of employment for transdisciplinary individuals. A commitment to sustainable use of the planet will provide employment and make better use of increasingly scarce resources.

  2. Sustainable Soil Management

    DEFF Research Database (Denmark)

    Green, Ole; Evgrafova, Alevtina; Kirkegaard Nielsen, Søren

    management strategies, which consider the site- and field-specific parameters and agricultural machinery’s improvements, it is possible to maximize production and income, while reducing negative environmental impacts and human health issues induced by agricultural activities as well as improving food......Linket til højre henviser til rapporten i trykt format til download. This report provides an overview on new technologies for integrate sustainable and resilient management practices in arable ecosystems for advanced farmers, consultants, NGOs and policy makers. By following sustainable soil...... and soil quality in short- and long-terms. This report also illustrates the importance to combine a system approach for plant production by assessing field readiness, managing in-field traffic management, implementing the sitespecific controlled as well as sensor-controlled seedbed preparation, seeding...

  3. CEA sustainable development report 2007

    International Nuclear Information System (INIS)

    2007-01-01

    The CEA, a prominent player in research development and innovation, is active in three main domains: energy, health care and information technology, defense and security. This annual report presents the CEA activities in the domain of the sustainable development. The first part is devoted to the environment preservation policy (energy, water, air, chemistry, wastes, transport, buildings). The second part shows the dynamic governance in the domain of the risks management. The last part presents the CEA activities of research for the sustainable development. (A.L.B.)

  4. Sustainable NREL - Site Sustainability Plan FY 2015

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2015-01-01

    NREL's Site Sustainability Plan FY 2015 reports on sustainability plans for the lab for the year 2015 based on Executive Order Goals and provides the status on planned actions cited in the FY 2014 report.

  5. Language Education for Sustainable Development

    Science.gov (United States)

    Zygmunt, Tomasz

    2016-01-01

    Nowadays, education for sustainable development starts covering wider and wider spheres of interest and human activity. Out of the three main spheres of interest, such as environmental, economic, and socio-cultural, the first two mentioned here seem to be given more attention than the sphere of socio-cultural activity. In this respect, the aim of…

  6. Protein pathway activation associated with sustained virologic response in patients with chronic hepatitis C treated with pegylated interferon (PEG-IFN) and ribavirin (RBV).

    Science.gov (United States)

    Younossi, Zobair M; Limongi, Dolores; Stepanova, Maria; Pierobon, Mariaelena; Afendy, Arian; Mehta, Rohini; Baranova, Ancha; Liotta, Lance; Petricoin, Emanuel

    2011-02-04

    Only half of chronic hepatitis C (CH-C) patients treated with pegylated interferon and ribavirin (PEG-IFN+RBV) achieve sustained virologic response) SVR. In addition to known factors, we postulated that activation of key protein signaling networks in the peripheral blood mononuclear cells (PBMCs) may contribute to SVR due to inherent patient-specific basal immune cell signaling architecture. In this study, we included 92 patients with CH-C. PBMCs were collected while patients were not receiving treatment and used for phosphoprotein-based network profiling. Patients received a full course of PEG-IFN+RBV with overall SVR of 55%. From PBMC, protein lysates were extracted and then used for Reverse Phase Protein Microarray (RPMA) analysis, which quantitatively measured the levels of cytokines and activation levels of 25 key protein signaling molecules involved in immune cell regulation and interferon alpha signaling. Regression models for predicting SVR were generated by stepwise bidirectional selection. Both clinical-laboratory and RPMA parameters were used as predictor variables. Model accuracies were estimated using 10-fold cross-validation. Our results show that by comparing patients who achieved SVR to those who did not, phosphorylation levels of 6 proteins [AKT(T308), JAK1(Y1022/1023), p70 S6 Kinase (S371), PKC zeta/lambda(T410/403), TYK2(Y1054/1055), ZAP-70(Y319)/Syk(Y352)] and overall levels of 6 unmodified proteins [IL2, IL10, IL4, IL5, TNF-alpha, CD5L] were significantly different (P < 0.05). For SVR, the model based on a combination of clinical and proteome parameters was developed, with an AUC = 0.914, sensitivity of 92.16%, and specificity of 85.0%. This model included the following parameters: viral genotype, previous treatment status, BMI, phosphorylated states of STAT2, AKT, LCK, and TYK2 kinases as well as steady state levels of IL4, IL5, and TNF-alpha. In conclusion, SVR could be predicted by a combination of clinical, cytokine, and protein signaling

  7. Impacts of Agricultural Practices and Tourism Activities on the Sustainability of Telaga Warna and Telaga Pengilon Lakes, Dieng Plateau, Central Java

    Directory of Open Access Journals (Sweden)

    Sudarmadji

    2018-01-01

    Full Text Available Telaga Warna and Telaga Pengilon are two volcanic lakes in the Dieng Plateau offer some unique phenomena which are interested for tourists to visit. Telaga Warna and Telaga Pengilon are located side by side in the Dieng Palteau. Those two lakes also have specific ecosystem which differ to other lakes. However as land use in the surrounding area is now gradually changing, the lake is now facing to environmental degradation. The land use in the surrounding area is for intensive agricultural which main crops are vegetable, especially potatoes. Meanwhile, the number of tourist visiting those two lakes is increasing; it may also give some impact to the lake environment. This research aims to study the impacts of agricultural practices and tourism activities to the lake environmental which lead to the environment sustainability of the lakes. The field survey was conducted to collect some data on lakes characteristics, agricultural and tourism activities. Some interviews to local people and tourists were also conducted. Some water and sediment samples were collected followed by laboratory analyses. Some secondary data from previous study was also collected. Data analysis was conducted based on qualitative and quantitative techniques. The study found that agricultural practices of potatoes plantation uses water from the Telaga Pengilon to irrigate the plant by pumping out the water using water pump and distributes the water over the plantation area. Agricultural practices lead to soil erosion, which contribute sediment to the lake carried by surface runoff. Therefore, the volume of lakes is gradually decreasing. The use of fertilizer in the agricultural practice contribute nutrient into the lake carried by surface runoff, leading to the eutrophication, due to the excess used of fertilizer. The study concludes that agricultural practices and tourism activities have some positive economic impacts to the local community, however it also give some adverse

  8. Sustainability : Politics and governance

    NARCIS (Netherlands)

    Heinrichs, Harald; Biermann, Frank

    2016-01-01

    he article gives an overview of global sustainability policy and politics. It is shown how international policy making on sustainable development has progressed from environmental policy toward recent approaches of Earth system governance. Key challenges of international sustainability politics are

  9. Sustainable Mobility

    DEFF Research Database (Denmark)

    Kjærulff, Aslak Aamot

    This paper combines strands of mobilities theory and planning theory, and develops a qualitative approach to look across emerging planning practices. By actively following 8 Danish urban and transport planners, over the course of 2 years, we learn how their practices have changed, inspired...... by mobility management, a concept aiming to reduce carbon emissions from transportation in western societies. The article focuses on how municipal planners formulate the role of mobility management activities organized around private companies, and how their practices are connected to wider ideas on planning....

  10. Textiles and clothing sustainability sustainable technologies

    CERN Document Server

    2017-01-01

    This is the first book to deal with the innovative technologies in the field of textiles and clothing sustainability. It details a number of sustainable and innovative technologies and highlights their implications in the clothing sector. There are currently various measures to achieve sustainability in the textiles and the clothing industry, including innovations in the manufacturing stage, which is the crux of this book.

  11. Sustainable diets within sustainable food systems.

    Science.gov (United States)

    Meybeck, Alexandre; Gitz, Vincent

    2017-02-01

    Sustainable diets and sustainable food systems are increasingly explored by diverse scientific disciplines. They are also recognised by the international community and called upon to orient action towards the eradication of hunger and malnutrition and the fulfilment of sustainable development goals. The aim of the present paper is to briefly consider some of the links between these two notions in order to facilitate the operationalisation of the concept of sustainable diet. The concept of sustainable diet was defined in 2010 combining two totally different perspectives: a nutrition perspective, focused on individuals, and a global sustainability perspective, in all its dimensions: environmental, economic and social. The nutrition perspective can be easily related to health outcomes. The global sustainability perspective is more difficult to analyse directly. We propose that it be measured as the contribution of a diet to the sustainability of food systems. Such an approach, covering the three dimensions of sustainability, enables identification of interactions and interrelations between food systems and diets. It provides opportunities to find levers of change towards sustainability. Diets are both the results and the drivers of food systems. The drivers of change for those variously involved, consumers and private individuals, are different, and can be triggered by different dimensions (heath, environment, social and cultural). Combining different dimensions and reasons for change can help facilitate the transition to sustainable diets, recognising the food system's specificities. The adoption of sustainable diets can be facilitated and enabled by food systems, and by appropriate policies and incentives.

  12. Sustainability and Organizational Change by Sustainable Crediting Therapy

    Directory of Open Access Journals (Sweden)

    Dragoş Ilie

    2012-06-01

    Full Text Available The objective of this paper is to demonstrate that one of the therapies to achieve sustainability and organizational change in the context of current challenges in the national economies is sustainable crediting. The research method is based on a survey of 30 commercial companies from various fields of activity that have or have not implemented, at the leadership level, the concept of sustainable crediting. The data collecting and processing approach has resulted in the determination of the main economic-financial indicators for a period of 5 years, indicators used by banks in relation with the credited organizations. The main results show that companies that have implemented the sustainable crediting concept are more able to achieve sustainability in their developed activity, as well as organizational change with positive effects on their business and on the company as a whole. The concept of sustainable crediting implies the capitalization of the commercial companies, the increase of the loan portfolio quality, the achievement of the financial balance and environmental protection

  13. Towards Sustainable Growth Business Models

    Energy Technology Data Exchange (ETDEWEB)

    Kamp-Roelands, N.; Balkenende, J.P.; Van Ommen, P.

    2012-03-15

    The Dutch Sustainable Growth Coalition (DSGC) has the following objectives: The DSGC aims to pro-actively drive sustainable growth business models along three lines: (1) Shape. DSGC member companies aim to connect economic profitability with environmental and social progress on the basis of integrated sustainable growth business models; (2) Share. DSGC member companies aim for joint advocacy of sustainable growth business models both internationally and nationally; and (3) Stimulate. DSGC member companies aim to stimulate and influence the policy debate on enabling sustainable growth - with a view to finding solutions to the environmental and social challenges we are facing. This is their first report. The vision, actions and mission of DSGC are documented in the Manifesto in Chapter 2 of this publication. Chapter 3 contains an overview of key features of an integrated sustainable growth business model and the roadmap towards such a model. In Chapter 4, project examples of DSGC members are presented, providing insight into the hands-on reality of implementing the good practices. Chapter 5 offers an overview of how the Netherlands provides an enabling environment for sustainable growth business models. Chapter 6 offers the key conclusions.

  14. HTA decision support system for sustainable business continuity management in hospitals. The case of surgical activity at the University Hospital in Florence.

    Science.gov (United States)

    Miniati, Roberto; Dori, Fabrizio; Cecconi, Giulio; Gusinu, Roberto; Niccolini, Fabrizio; Gentili, Guido Biffi

    2013-01-01

    A fundamental element of the social and safety function of a health structure is the need to guarantee continuity of clinical activity through the continuity of technology. This paper aims to design a Decision Support System (DSS) for medical technology evaluations based on the use of Key Performance Indicators (KPI) in order to provide a multi-disciplinary valuation of a technology in a health structure. The methodology used in planning the DSS followed the following key steps: the definition of relevant KPIs, the development of a database to calculate the KPIs, the calculation of the defined KPIs and the resulting study report. Finally, the clinical and economic validation of the system was conducted though a case study of Business Continuity applied in the operating department of the Florence University Hospital AOU Careggi in Italy. A web-based support system was designed for HTA in health structures. The case study enabled Business Continuity Management (BCM) to be implemented in a hospital department in relation to aspects of a single technology and the specific clinical process. Finally, an economic analysis of the procedure was carried out. The system is useful for decision makers in that it precisely defines which equipment to include in the BCM procedure, using a scale analysis of the specific clinical process in which the equipment is used. In addition, the economic analysis shows how the cost of the procedure is completely covered by the indirect costs which would result from the expenses incurred from a broken device, hence showing the complete auto-sustainability of the methodology.

  15. The new industrial political tools based on the sustainable development of productive activities; Gli strumenti attuativi di una politica di sviluppo sostenibile dell'impresa

    Energy Technology Data Exchange (ETDEWEB)

    Luciani, R.; Andriola, L. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Ambiente

    1999-07-01

    The new industrial political tools based on the sustainable development of productive activities, and originating at the Rio Conference in 1992, late introduced by the European Union, the Government and voluntary organizations (ISO, CEM, UNI) are gradually entering the market, thereby underling their effect in terms of industrial competitiveness. The main tools were examined in the report and mostly refer to the voluntary ones which, in surpassing the command and control logic, increasingly tend to get close to traditional fiscal, tariff and financial ones. Voluntary agreements, environmental management systems (EMAS, ISO14000), the risk prevention systems (UNI 10617), certification (Ecolabel, ISO 14040) and environment communications tools (environment balance sheet, environmental report, environmental statement) are synthetically described. Finally, the tools regarding the incentives still under Government concern an their diffusion are examined. [Italian] I nuovi strumenti di politica industriale orientati allo sviluppo sostenibile delle attivita' produttive che traggono origine dalla Conferenza di Rio del 1992 e sono stati introdotti successivamente da parte della Comunita' Europea, dal Governo e dagli organismi di normazione volontaria (ISO, CEN, UNI), stanno gradualmente penetrando sul mercato facendo valere i loro effetti anche in termini di competitivita' delle imprese. Nel rapporto sono stati esaminati i principali tra questi strumenti con particolare riferimento a quelli volontari che sempre piu', nel superamento della logica del {sup c}ommand-control{sup ,} tendono ad affiancarsi a quelli tradizionali di carattere fiscale, tariffario e finanziario. In particolare vengono descritti sinteticamente gli accordi volontari, i sistemi di gestione ambientali e della sicurezza (EMAS, norme ISO 14001 e UNI 10617), la certificazione di prodotto (Ecolabel, norma ISO 14040) e gli strumenti di comunicazione ambientale (bilancio ambientale, rapporto

  16. The new industrial political tools based on the sustainable development of productive activities; Gli strumenti attuativi di una politica di sviluppo sostenibile dell'impresa

    Energy Technology Data Exchange (ETDEWEB)

    Luciani, R; Andriola, L [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Ambiente

    1999-07-01

    The new industrial political tools based on the sustainable development of productive activities, and originating at the Rio Conference in 1992, late introduced by the European Union, the Government and voluntary organizations (ISO, CEM, UNI) are gradually entering the market, thereby underling their effect in terms of industrial competitiveness. The main tools were examined in the report and mostly refer to the voluntary ones which, in surpassing the command and control logic, increasingly tend to get close to traditional fiscal, tariff and financial ones. Voluntary agreements, environmental management systems (EMAS, ISO14000), the risk prevention systems (UNI 10617), certification (Ecolabel, ISO 14040) and environment communications tools (environment balance sheet, environmental report, environmental statement) are synthetically described. Finally, the tools regarding the incentives still under Government concern an their diffusion are examined. [Italian] I nuovi strumenti di politica industriale orientati allo sviluppo sostenibile delle attivita' produttive che traggono origine dalla Conferenza di Rio del 1992 e sono stati introdotti successivamente da parte della Comunita' Europea, dal Governo e dagli organismi di normazione volontaria (ISO, CEN, UNI), stanno gradualmente penetrando sul mercato facendo valere i loro effetti anche in termini di competitivita' delle imprese. Nel rapporto sono stati esaminati i principali tra questi strumenti con particolare riferimento a quelli volontari che sempre piu', nel superamento della logica del {sup c}ommand-control{sup ,} tendono ad affiancarsi a quelli tradizionali di carattere fiscale, tariffario e finanziario. In particolare vengono descritti sinteticamente gli accordi volontari, i sistemi di gestione ambientali e della sicurezza (EMAS, norme ISO 14001 e UNI 10617), la certificazione di prodotto (Ecolabel, norma ISO 14040) e gli strumenti di comunicazione ambientale (bilancio ambientale, rapporto ambientale

  17. SUSTAINABILITY IN THE CONTEXT OF GLOBALIZATION

    Directory of Open Access Journals (Sweden)

    Leontina Beţianu

    2009-09-01

    Full Text Available Sustainability tends to become in the new millennium the most important characteristic of economic and social development. The possibility to ensure economic development in the context of a reasonable use of raw materials, energy and natural resources in general and to decrease the impact of all human activities on the environment makes the essence of the sustainable development of these activities.

  18. Cultural heritage and sustainable development in SUIT

    DEFF Research Database (Denmark)

    Algreen-Ussing, Gregers; Hassler, Uta; Kohler, Niklaus

    2002-01-01

    The position paper is composed of 18 thesis, which are presented in four groups: Cultural Heritage, Momuments and Public Space, Active Conservation and Sustainable Development.......The position paper is composed of 18 thesis, which are presented in four groups: Cultural Heritage, Momuments and Public Space, Active Conservation and Sustainable Development....

  19. University involvement in sustainability initiatives

    DEFF Research Database (Denmark)

    Lehmann, Martin; Christensen, Per; Thrane, Mikkel

    2007-01-01

    With an outset in the case of Aalborg University, the linkages (actual, potential and missing) between academic work in research & education and sustainability initiatives are explored. The focus is both on the university's core activities as a provider of research and education and on the univer......With an outset in the case of Aalborg University, the linkages (actual, potential and missing) between academic work in research & education and sustainability initiatives are explored. The focus is both on the university's core activities as a provider of research and education...... and on the university's activities as an organisation, i.e. its own operation and its accounting for this. Sustainability is defined as a continuous process requiring balance between (the emergence of) problems and our ability and capability to solve them. Some core questions that this paper seeks to answer are: "How...... is Sustainable Development understood at executive level at the university? How (if at all) is sustainable development integrated in the core activities of the university? How is the university attached to ‘real life outside the ivory tower', e.g. through the establishing of Public-Private-Academic Partnerships...

  20. The social sustainability of entrepreneurship

    DEFF Research Database (Denmark)

    Bjerregaard, Toke; Lauring, Jakob

    2012-01-01

    Sustainable entrepreneurship is attracting increasing attention in entrepreneurship literature. Social sustainable entrepreneurship is often conceived as entrepreneurial processes that generate social value. In this chapter we illuminate how small business entrepreneurs in a developing country...... engage in activities of importance for social sustainability and development as they undertake entrepreneurial ventures. We present the findings from an ethnographic field study that examines the strategies used by small entrepreneurs in an area of extreme resource scarcity to navigate co-existing social...... and market logics. The cases elucidate how the entrepreneurs cope with and exploit such co-existing logics through their sphere-straddling ventures to ensure sustainability during changes from an economy based on traditional exchange relationships to a situation with an emerging market economy. The chapter...

  1. Are the effects of a non-drug multimodal activation therapy of dementia sustainable? Follow-up study 10 months after completion of a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Luttenberger Katharina

    2012-12-01

    Full Text Available Abstract Background Little is known about the long-term success of non-drug therapies for treating dementia, especially whether the effects are sustained after therapy ends. Here, we examined the effects of a one-year multimodal therapy 10 months after patients completed the therapy. Methods This randomised, controlled, single-blind, longitudinal trial involved 61 patients (catamnesis: n = 52 with primary degenerative dementia in five nursing homes in Bavaria, Germany. The highly standardised intervention, MAKS, consisted of motor stimulation, practice of activities of daily living (ADLs, and cognitive stimulation. Each group of 10 patients was treated for 2 h, 6 days a week for 12 months. Control patients received standard nursing home care. At baseline, at the end of therapy (month 12, and 10 months thereafter (month 22, cognitive functioning was assessed using the cognitive subscale of the Alzheimer’s Disease Assessment Scale, and the ability to perform ADLs was assessed using the Erlangen Test of Activities of Daily Living. Results During the therapy phase, the MAKS patients maintained their cognitive function and ability to carry out ADLs. After the end of therapy, both the control and the MAKS groups deteriorated in both their cognitive function (control, p = 0.02; MAKS, p 0: βMAKS + βMAKS month 22 = 0; χ2 = 3.8568, p = 0.0496. Cohen’s d for the difference between the two groups in ADLs and cognitive abilities 10 months after the end of therapy was 0.40 and 0.22, respectively. Conclusions A multimodal non-drug therapy of dementia resulted in stabilisation of the ability to perform ADLs, even beyond the end of therapy. To prevent functional decline for as long as possible, therapy should be performed continuously until the benefit for the patient ends. Follow-up studies on larger numbers of patients are needed to definitively confirm these results. Trial registration http://www.isrctn.com Identifier: ISRCTN

  2. Ethics and sustainability

    International Nuclear Information System (INIS)

    Jimenez Mejia, Jose Fernando

    2002-01-01

    It could be said that the concept of sustainability is based on ethic postulates, because it claims to bear in mind the set of necessities of future generations as a control variable for human development models and for consumption patterns. Ethics, in its own, mainly in the spinozist line of thinking, is a philosophical proposal directed to empowering the operations of expression of the beings (not only of the human being). This ethics outlines multiple developments and conceive future generations not as undifferentiated, passive and impotent collectives, but as active and joyful communities, who are sensitive to the possibilities of their own devenir

  3. Partnering for a greener community, Virginia Tech, the Town of Blacksburg, and Sustainable Blacksburg present Sustainability Week 2008

    OpenAIRE

    Harris, Jennifer

    2008-01-01

    Virginia Tech, the Town of Blacksburg and Sustainable Blacksburg have partnered to present Sustainability Week 2008, Oct. 20 through 25. During Sustainability Week more than 20 activities, events and tours, focused on building and sustaining a greener community, have been scheduled.

  4. Assessing sustainable remediation frameworks using sustainability principles.

    Science.gov (United States)

    Ridsdale, D Reanne; Noble, Bram F

    2016-12-15

    The remediation industry has grown exponentially in recent decades. International organizations of practitioners and remediation experts have developed several frameworks for integrating sustainability into remediation projects; however, there has been limited attention to how sustainability is approached and operationalized in sustainable remediation frameworks and practices - or whether sustainability plays any meaningful role at all in sustainable remediation. This paper examines how sustainability is represented in remediation frameworks and the guidance provided for practical application. Seven broad sustainability principles and review criteria are proposed and applied to a sample of six international remediation frameworks. Not all review criteria were equally satisfied and none of the frameworks fully met all criteria; however, the best performing frameworks were those identified as sustainability remediation frameworks. Intra-generational equity was addressed by all frameworks. Integrating social, economic and biophysical components beyond triple-bottom-line indicators was explicitly addressed only by the sustainable remediation frameworks. No frameworks provided principle- or rule-based guidance for dealing with trade-offs in sustainability decisions. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Corporate Sustainability Management and Environmental Ethics

    DEFF Research Database (Denmark)

    Schuler, Douglas; Rasche, Andreas; Etzion, Dror

    2017-01-01

    This article reviews four key orientations in environmental ethics that range from an instrumental understanding of sustainability to one that acknowledges the intrinsic value of sustainable behavior (i.e., sustainable resource use, conservation and preservation, rights-based perspectives, and deep...... ecology). It then shows that the current scholarly discourse around corporate sustainability management—as reflected in environment management (EM), corporate social responsibility (CSR), and corporate political activity (CPA)—mostly favors an instrumental perspective on sustainability. Sustainable...... business practices are viewed as anthropocentric and are conceptualized as a means to achieve competitive advantage. Based on these observations, we speculate about what corporate sustainability management might look like if it applied ethical orientations that emphasize the intrinsic value of nature...

  6. Sustainability partnerships and viticulture management in California.

    Science.gov (United States)

    Hillis, Vicken; Lubell, Mark; Hoffman, Matthew

    2018-07-01

    Agricultural regions in the United States are experimenting with sustainability partnerships that, among other goals, seek to improve growers' ability to manage their vineyards sustainably. In this paper, we analyze the association between winegrape grower participation in sustainability partnership activities and practice adoption in three winegrowing regions of California. Using data gathered from a survey of 822 winegrape growers, we find a positive association between participation and adoption of sustainable practices, which holds most strongly for practices in which the perceived private benefits outweigh the costs, and for growers with relatively dense social networks. We highlight the mechanisms by which partnerships may catalyze sustainable farm management, and discuss the implications of these findings for improving sustainability partnerships. Taken together, we provide one of the most comprehensive quantitative analyses to date regarding the effectiveness of agricultural sustainability partnerships for improving farm management. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. Technology and sustainability

    NARCIS (Netherlands)

    Kroeze, C.; Boersema, J.J.; Tellegen, E.; Cremers, A.

    2011-01-01

    In ten essays, this book addresses a broad range of issues related to the interplay of sustainability and technology. How do population growth and technology relate to sustainable development? Can globalization be reconciled with sustainable development? Is sustainability a subjective or an

  8. Sustainable consumption and marketing

    NARCIS (Netherlands)

    Dam, van Y.K.

    2016-01-01

    Sustainable development in global food markets is hindered by the discrepancy between positive consumer attitudes towards sustainable development or sustainability and the lack of corresponding sustainable consumption by a majority of consumers. Apparently for many (light user) consumers the

  9. Externality or sustainability economics?

    International Nuclear Information System (INIS)

    Bergh, Jeroen C.J.M. van den

    2010-01-01

    In an effort to develop 'sustainability economics' Baumgaertner and Quaas (2010) neglect the central concept of environmental economics-'environmental externality'. This note proposes a possible connection between the concepts of environmental externality and sustainability. In addition, attention is asked for other aspects of 'sustainability economics', namely the distinction weak/strong sustainability, spatial sustainability and sustainable trade, distinctive sustainability policy, and the ideas of early 'sustainability economists'. I argue that both sustainability and externalities reflect a systems perspective and propose that effective sustainability solutions require that more attention is given to system feedbacks, notably other-regarding preferences and social interactions, and energy and environmental rebound. The case of climate change and policy is used to illustrate particular statements. As a conclusion, a list of 20 insights and suggestions for research is offered. (author)

  10. ECO-SUSTAINABLE DEVELOPMENT AND ROMANIAN TOURISM

    Directory of Open Access Journals (Sweden)

    MARIANA BĂLAN

    2014-05-01

    Full Text Available In a changing world, the development of eco-sustainable tourism is manifested in the form of interaction of elements compatible with each other in various dimensions: economic, environmental, human, technological, environmental, ethical, etc. Through eco-sustainable tourism aims to satisfy the present needs of tourists in favor and not in detrimental to the interests of future generations, along with educating them in the spirit of reducing negative environmental impacts. This paper provides a brief overview of the tourism - ecology - sustainable development relationship, by highlighting the evolutionary theoretical considerations regarding the concept of tourism, the need for sustainable tourism development, the ecology as a priority in the development and integration of tourism activities within the coordinates the eco-sustainable development. It also discusses the main indicators used to characterize the tourism activities in Romania in the context of eco-sustainable development.

  11. Sustainable development

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    The new year begins with some important changes for members of the CERN personnel. The measures proposed by the Management following the five-yearly review of employment conditions, which were approved by the Council in December 2015, will be implemented gradually. What changes can we expect?   The aim of the five-yearly review is the pursuit of excellence across all of CERN’s activities. This is not just a hollow slogan but a joint commitment made by all those involved: the Management, the personnel, as represented by the Staff Association, and the Member States. The five-yearly review is a painstaking and complex process: every five years, the employment conditions of the CERN personnel are examined to evaluate whether the Organization continues to attract, retain and motivate personnel of the highest competence and integrity, as required for the execution of its mission. “As in every five-yearly review, we compared our employment conditions with those in the Member States,&...

  12. Experimental Standards in Sustainability Transitions

    DEFF Research Database (Denmark)

    Hale, Lara Anne

    In this thesis I address how experimental standards are used in the new governance paradigm to further sustainability transitions. Focusing on the case of the Active House standard in the building sector, I investigate experimental standards in three research papers examining the following dynamics......: (1) the relationship between commensuration and legitimacy in the formulation and diffusion of a standard’s specifications; (2) the role of awareness in standardizing green default rules to establish sustainable consumption in buildings; and (3) the significance of focus on humans in the development...... of technological standards for sustainable building. Launching from a critical realist social ontology, I collected ethnographic data on the Active House Alliance, its cofounder VELUX, and three of their demonstration building projects in Austria, Germany, and Belgium over the course of three years from 2013...

  13. Problem Based Learning and sustainability

    DEFF Research Database (Denmark)

    Pizzol, Massimo; Løkke, Søren; Schmidt, Jannick Højrup

    and challenges that the PBL model offers for developing five key competences in sustainability: (i) system thinking, (ii) interpersonal competence, (iii) anticipatory competence, (iv) strategic competence, (v) normative competences. The study draws on the experiences from PBL activities performed at Aalborg...... University (AAU), Denmark, and focuses on the teaching of Life Cycle Assessment as a method for sustainability assessment. The objective is providing recommendations for future LCA teaching and learning. PBL activites performed at AAU were evaluated critically to detemine to what extent they addressed...... of how PBL-approaches were used to develop five specific competences in sustainability. It is concluded that -for the case fo LCA teaching at AAU- the PBL model included activities to develop system thinking, interpersonal competence, and normative competence. However, the PBL approach should...

  14. Responsible marketing for sustainable tourism

    Directory of Open Access Journals (Sweden)

    Jegdić Vaso

    2014-01-01

    Full Text Available The biggest challenge associated with the concept of sustainable tourism is its operationalisation and perception as a process to be applied through development plans, projects and ongoing activities of tour operators. The traditional approach to marketing, focused on a limited idea of maximising profit businesses, was not able to respond to a number of social and environmental requirements imposed by the concept of sustainable development. This paper discusses the ways in which marketing could play a more important role in the sustainable development of tourism. This refers to the determination of consumer needs and preferences, the formation of certain products and pricing, product information and advertising to consumers of their benefits in a sustainable manner, as well as adequate distribution channels used by businesses to deliver products to consumers. Environmental and social marketing are now being confirmed as important elements of a much broader marketing perspective. In order to develop tourism with sustainable outcomes, responsible marketing can be crucial. The concept of marketing mix for sustainable tourism was used as a starting point to explore the specific role of responsible marketing in tourism.

  15. Sustainability Assessment Using a Unit-based Sustainability ...

    African Journals Online (AJOL)

    need to balance economic growth and social progress with environmental concerns ... They play a special role in seeking solutions to societal ... development, and also helps to establish the current status of sustainability work in progress. .... departments, units and/or facets of university life (e.g. student activities or estates ...

  16. Supply Chain Sustainability: a Retailer Perspective

    OpenAIRE

    ROWELL, James

    2011-01-01

    Since the publication of 'The Greening of Wal-Mart's Supply Chain' (Plambeck, 2007) the subject of sustainability has gained a clear focus in organisations' supply chain activities. (The Sustainable Business, EFMD, 2010) In fact the 2007 paper reported on Walmart's ambitions as outlined by CEO Lee Scott, in 2005. That plan was titled Sustainability 360. Based on information published by Walmart since 2007, this article discusses the organisational context of these initiatives and focuses on t...

  17. National strategy for sustainable development: 5. report

    International Nuclear Information System (INIS)

    2009-01-01

    After an introduction on the assessment and perspectives of the French national strategy for a sustainable development, this report presents actions which are associated with different themes: social dimension of the sustainable development, the citizen as an actor of sustainable development, territories, economic activities, companies and consumers, climate change and energy, transports, agriculture and fishery, prevention of risks, pollutions and other hazards for health and the environment, an exemplary State, research and innovation, international action

  18. Sustainability in Business

    DEFF Research Database (Denmark)

    Tollin, Karin; Vej, Jesper

    2012-01-01

    How do companies integrate sustainability into their strategy and practices, and what factors explain their approach? In this paper a typology of sustainability strategies is presented as well as a conceptual framework relating sustainability at the company level to the functional level of market...... managers' mindsets, a framework addressing sustainability from four organisational learning schools was designed and followed......How do companies integrate sustainability into their strategy and practices, and what factors explain their approach? In this paper a typology of sustainability strategies is presented as well as a conceptual framework relating sustainability at the company level to the functional level...... of marketing. The central contribution of the typology is a strategic and managerial view on sustainability. Furthermore, the typology shows that sustainability in business is enacted from different areas of competences and fields in the literature (e.g. supply chain management, corporate branding, value...

  19. Sustainability in Chemical Engineering Curriculum

    Science.gov (United States)

    Glassey, Jarka; Haile, Sue

    2012-01-01

    Purpose: The purpose of this paper is to describe a concentrated strategy to embed sustainability teaching into a (chemical) engineering undergraduate curriculum throughout the whole programme. Innovative teaching approaches in subject-specific context are described and their efficiency investigated. Design/methodology/approach: The activities in…

  20. Winning the sustainable development debate

    International Nuclear Information System (INIS)

    Ritch, John; Cornish, Emma

    2002-01-01

    on a vast scale Access to energy - and in particular, electricity - will be critical if the world is to achieve these human goals. Access to clean electricity - and on a vast scale - will be necessary if the world is to meet the twin challenges of human need and environmental security. Anti-nuclear forces, which have held sway in the Kyoto process thus far, argue that nuclear energy is a dying technology and assert passionately that it has no place in tomorrow's sustainable development agenda. These ideologically driven arguments ignore underlying realities both as to what is feasible and what is actually occurring. Today, nuclear power plants are operational in countries comprising 64% of the world's population, and new power reactors are in the planning or construction stage in countries representing no less than 50% of the world's population. Among the latter are the world's two largest developing countries, China and India, which alone represent 40% of humankind and about half the developing world. With active nuclear reactor construction under way as we speak, these leading nations have already made nuclear power a part of their sustainable development strategies for the 21st century. Winning the sustainable development debate - This presentation will share information materials about sustainable development. It will describe the work of the World Nuclear Association Sustainable Development Strategy Group, its preparations for the World Summit on Sustainable Development, and how participants to PIME can get involved. (author)

  1. Sustainable Table | Welcome to Sustainable Table

    Science.gov (United States)

    Sustainable Seafood Industrial Agriculture Industrial Livestock Production Antibiotics Hormones rBGH Animal , safeguarding animal welfare and supporting local communities. Questions to Ask Asking questions is the best way Livestock Husbandry Sustainable Crop Production Innovative Agriculture New Farmers Organic Agriculture Local

  2. Education for sustainable development

    DEFF Research Database (Denmark)

    Breiting, Søren

    2009-01-01

     An introduction to the idea of sustainable development (SD) and education for sustainable development (ESD) with reference to the international Decade for Education for Sustainable Development . The chapter includes a focus on conflicting interests between present and future generations related ...... to the use of natural resources and other matters, and how that kind of issues can be dealt with in education as ESD....... An introduction to the idea of sustainable development (SD) and education for sustainable development (ESD) with reference to the international Decade for Education for Sustainable Development . The chapter includes a focus on conflicting interests between present and future generations related...

  3. Quality and land use for a sustainable development: bio markers for the soil microbial activity; Calidad y uso del suelo para un desarrollo sostenible: importancia de biomarcadores de la actividad microbiana del suelo

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Izquierdo, C.

    1996-12-01

    Nowadays, to define and assess criteria of soil quality is acquiring an increasingly interest since it will allow to know th influence of different land uses on soil quality. It is so necessary to establish a minimum set of parameters, related with physical, chemical, biological and biochemical properties of soils, which measurement allows us to know the level of quality of a soil. Among the different soil parameters liable to be measured, those which are bio markers of soil microbial activity are, due to their sensitivity, the most useful to know in a quick and effective way the changes brought about in soil quality by soil management. This will help to take decisions on the most sustainable land uses in order to maintain a soil sustainable productivity. (Author) 11 refs.

  4. Smart Sustainable Islands VS Smart Sustainable Cities

    Science.gov (United States)

    Pantazis, D. N.; Moussas, V. C.; Murgante, B.; Daverona, A. C.; Stratakis, P.; Vlissidis, N.; Kavadias, A.; Economou, D.; Santimpantakis, K.; Karathanasis, B.; Kyriakopoulou, V.; Gadolou, E.

    2017-09-01

    This paper has several aims: a) the presentation of a critical analysis of the terms "smart sustainable cities" and "smart sustainable islands" b) the presentation of a number of principles towards to the development methodological framework of concepts and actions, in a form of a manual and actions guide, for the smartification and sustainability of islands. This kind of master plan is divided in thematic sectors (key factors) which concern the insular municipalities c) the creation of an island's smartification and sustainability index d) the first steps towards the creation of a portal for the presentation of our smartification actions manual, together with relative resources, smart applications examples, and, in the near future the first results of our index application in a number of Greek islands and e) the presentation of some proposals of possible actions towards their sustainable development and smartification for the municipalities - islands of Paros and Antiparos in Greece, as case studies.

  5. Roadmapping towards Sustainability Proficiency in Engineering Education

    Science.gov (United States)

    Rodriguez-Andara, Alejandro; Río-Belver, Rosa María; Rodríguez-Salvador, Marisela; Lezama-Nicolás, René

    2018-01-01

    Purpose: The purpose of this paper is to deliver a roadmap that displays pathways to develop sustainability skills in the engineering curricula. Design/methodology/approach: The selected approach to enrich engineering students with sustainability skills was active learning methodologies. First, a survey was carried out on a sample of 189 students…

  6. Workshops in Dutch sustainable building design practice

    NARCIS (Netherlands)

    Zeiler, W.; Quanjel, E.M.C.J.; Borsboom, W.A.

    2009-01-01

    Within the present context of the Dutch Sustainable Building Practice it is hard for the different involved building design disciplines to give a good answer to sustainability. Especially this is the case for the application solar energy either in passive or active form. As traditional methods did

  7. University Sustainability Reporting: Taking Stock of Transparency

    Science.gov (United States)

    Bice, Sara; Coates, Hamish

    2016-01-01

    This paper interrogates the case for improved and broadened public sustainability reporting by universities, and explores whether and how global performance measures capture the institutional attitudes and activities pertinent to universities' contributions to sustainability. The analysis explores all stand-alone, English language reports produced…

  8. Educating Engineers for Sustainable Development

    DEFF Research Database (Denmark)

    Myrdal, Christina Grann; Holgaard, Jette Egelund

    In this paper, we explore the potentials of designing engineering education activities for sustainability development based on how environmental concerns are integrated into product development processes in a company context. First we draw on a case study from the Danish company Grundfos Management...... A/S and based on their experience with product development practise and competence development of product developers, we propose a set of competences to be addressed in engineering education for sustainable development (EESD). Furthermore, we use the problem based learning philosophy as a base...

  9. Focus on sustainability.

    Science.gov (United States)

    Thompson, R J; Godiksen, L; Hansen, G; Gustafson, D J; Brinkerhoff, D W; Ingle, M D; Rounds, T; Wing, H

    1990-01-01

    In recent years, sustainability has become one of the most critical concepts in international development and is having a dramatic impact on the way development is conceptualized and carried out. The US Agency for International Development (USAID) is incorporating this concept into its programs and projects. Factors encouraging sustainability of projects and programs include host government policies that support or constrain program objectives, national and/or local commitment to project goals, managerial leadership that helps shape improved policies, collaboration at all staff levels in program management, financial resources that cover program operational costs, appropriate program technology, integration of the program with the social and cultural setting of the country, community involvement in the program, sound environmental management, technical assistance oriented to transferring skills and increasing institutional capacity, perception by the host country that the project is "effective," training provided by the project to transfer skill needed for capacity-building, integration of the program into existing institutional framework, and external political, economic and environmental factors. Impediments to sustainability are often inherent in the donor agency's programming process. This includes the implicit assumption that program objectives can be accomplished in a relatively short time frame, when in fact capacity-building requires a lengthy commitment. USAID professionals are pressured to show near-term results which emphasize outputs rather than purpose and goal-level accomplishments achievable only after extensive effort. The emphasis on obligating money and on the project paper as a sales document leads project designers to talk with a great deal more certainty about project results than is warranted by the complex development situation. Uncertainty and flexibility should be designed into projects so activities and objects can change as more

  10. Is Sustainable Remediation Now a Self-Sustaining Process? an International Progress Report

    Science.gov (United States)

    Smith, J. W. N.

    2014-12-01

    Sustainable remediation - the consideration of environmental, social and economic factors associated with soil and groundwater risk-management options, to help select the best overall solution - has been a rapidly evolving topic in recent years. The first published reference[1] to 'sustainable remediation' was in the title of a 1999 conference paper by Kearney et al., (1999), but activity really accelerated in the middle-late 2000's, with establishment of a number of collaborative sustainable remediation groups and fora, and increased publication rates in the peer reviewed literature (Fig 1). Figure 1. Journal paper publications with search term 'sustainable remediation' (SCOPUS survey, 17 July 2014) This presentation will review the international progress of sustainable remediation concept development and application in regulatory and corporate decision-making processes. It will look back at what has already been achieved, provide an update on the latest initiatives and developments, and look forward to what the future of sustainable remediation might look like. Specifically it will describe: Sustainable remediation frameworks: synergies and international collaboration; Latest guidance and tools developed by the various sustainable remediation organisations (SuRFs), including the SuRF-UK Best Management Practices and Tier 1 Briefcase; Best practice standard development by ASTM and ISO; Regulatory acceptance of sustainable remediation, including incorporation into legislation, and the NICOLE - Common Forum Joint statement on 'risk-informed and sustainable remediation' in Europe; Examples of corporate adoption of sustainable remediation principles. The presentation will conclude with a look forward to a vision of sustainable remediation in 2020.

  11. Handbook of sustainable engineering

    CERN Document Server

    Lee, Kun-Mo

    2013-01-01

    "The efficient utilization of energy, sustainable use of natural resources, and large-scale adoption of sustainable technologies is the key to a sustainable future. The Handbook of Sustainable Engineering provides tools that will help us achieve these goals". Nobel Prize Winner Dr. R.K. Pauchauri, Chairman, UN Intergovernmental Panel on Climate Change As global society confronts the challenges of diminishing resources, ecological degradation, and climate change, engineers play a crucial role designing and building technologies and products that fulfil our needs for utility and sustainability. The Handbook of Sustainable Engineering equips readers with the context and the best practices derived from both academic research and practical examples of successful implementations of sustainable technical solutions. The handbook’s content revolves around the two themes, new ways of thinking and new business models, including sustainable production, products, service systems and consumption while addressing key asse...

  12. Sustainable Water Infrastructure

    Science.gov (United States)

    Resources for state and local environmental and public health officials, and water, infrastructure and utility professionals to learn about sustainable water infrastructure, sustainable water and energy practices, and their role.

  13. Sustainable development. First part

    International Nuclear Information System (INIS)

    Colombo, U.; Lanzavecchia, G.; Berrini, M; Zambrini, M.; Bologna, G.; Carraro, C.; Hinterberger, F.; Mastino, G.; Federico, A.; Gaudioso, D.; Luise, A.; Mauro, F.; Padovani, L.; Federico, A.

    1998-01-01

    This paper summarizes a collective effort and represents the second edition of: Environment, energy, economy: a sustainable future. In this work are reported various interventions on sustainable development problem [it

  14. Sustainable Public Bids

    Directory of Open Access Journals (Sweden)

    Gil César Costa de Paula

    2016-06-01

    Full Text Available In this article we will discuss the issue of sustainability in public procurement, given that the government in Brazil is constituted as a great promoter of economic development and needs to adapt its acquisitions worldwide sustainability agenda.

  15. Neighbourhood facilities for sustainability

    CSIR Research Space (South Africa)

    Gibberd, Jeremy T

    2013-01-01

    Full Text Available . In this paper these are referred to as ‘Neighbourhood Facilities for Sustainability’. Neighbourhood Facilities for Sustainability (NFS) are initiatives undertaken by individuals and communities to build local sustainable systems which not only improve...

  16. FORUM: Is Ecotourism Sustainable?

    Science.gov (United States)

    Wall

    1997-07-01

    / It is legitimate to ask whether and in what form tourism might contribute to sustainable development. This is not the same as sustainable tourism which, as a single-sector approach to development, may overlook important linkages with other sectors. If tourism is to contribute to sustainable development, then it must be economically viable, ecologically sensitive and culturally appropriate. Ecotourism is often advocated as being a sustainable form of tourism but imprecision in terminology clouds basic issues and there are strong economic, ecological, and cultural reasons for believing that, even in its purest forms, ecotourism is likely to present substantial challenges to destination areas, particularly if it competes for scarce resources and displaces existing uses and users. Sustainable tourism and ecotourism are not synonyms, many forms of ecotourism may not be sustainable, and if ecotourism is to contribute to sustainable development, then careful planning and management will be required.KEY WORDS: Ecotourism; Sustainable development; Development; Tourism

  17. Sustainable energy in Baltic States

    International Nuclear Information System (INIS)

    Klevas, Valentinas; Streimikiene, Dalia; Grikstaite, Ramute

    2007-01-01

    Integration of New Member States to the European Union has created a new situation in the frame of implementation of the Lisbon strategy and EU Sustainable Development. The closure of Ignalina NPP is the biggest challenge to the energy sector development of the Baltic States. The Baltic States have quite limited own energy resources and in the Accession agreement with the EU Lithuania, Latvia and Estonia have verified their targets to increase the share of electricity produced from renewable energy sources (RES-E) by the year 2010. A wider use of renewable energy and increase of energy efficiency can make a valuable contribution to meeting the targets of sustainable development. The article presents a detailed overview of the present policies and measures implemented in the Baltic States, aiming to support the use of RES and the increase of energy efficiency. The review of possibilities to use the EU Structural Funds (SF) for the implementation of sustainable energy projects in the Baltic States was performed.The use of regional social-economic-environmental indicators is the main key to integrate sustainable energy development at the program deployment level. The indicators to be used should describe the contribution of energy programs to the sustainable development, medium- and long-term trends and inter-relationship between them and the typical energy indicators (saved toe, improved energy efficiency, percentage of RES). Municipalities may play a considerable role by promoting sustainable energy since local authorities are fulfilling their functions in the energy sector via a number of roles. The Netherlands' example shows that municipalities may act as facilitators by implementing national environmental policy and increasing energy efficiency in an integral part of these activities. The guidelines for Lithuanian local sustainable energy development using the SF co-financing have been presented

  18. Sustainability on-the-go

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    on sustainability-- The Good Guide, Carrotmob and Colalife. Each organization demonstrates a web presence through social media that are available on mobile devices. This paper examines the mobile space as a space for examining the potential impacts of a technology mediated interaction focused on sustainability...... as an extension of consumer identity and conscience. Using Gee’s focus on the connection between language use, technology and context as part of identities in interaction, this paper also explores the potential and implications of mobile technologies for the communication of sustainable values. Technology...... is approached through the tension between McLuhan’s notion of physical extension and as E.T Hall’s description of technology as an extension of cultural practice. (Rogers 2000). Conclusions include understanding the shift to mobile technology as offering a space in which consumer identity plays an active role...

  19. Stakeholder Thinking in Sustainability Management

    DEFF Research Database (Denmark)

    Gjerdrum Pedersen, Esben Rahbek; Hove Henriksen, Morten; Frier, Claus

    2013-01-01

    Purpose – The objective of the paper is to describe and discuss how the biotech company Novozymes integrates stakeholder thinking into everyday sustainability practices. Design/methodology/approach – The paper is based on first-hand experiences as well as secondary information from Novozymes' sta...... to make sense of stakeholder thinking. Originality/value – The contribution of this paper is to provide a detailed analysis of how various stakeholder relations management methods can be used in practice to integrate sustainability in an organisation.......' stakeholder-oriented sustainability activities. Findings – The paper illustrates how a company is striving to transform the general stakeholder principles into concrete, manageable actions. Moreover, the paper describes some of the needs, challenges, and paradoxes experienced by an organisation that is trying...

  20. Sustainability Statement and Policy

    Science.gov (United States)

    Journal of Education for Sustainable Development, 2009

    2009-01-01

    This article presents nine resources that focus on environmental education and sustainability. These include: (1) "Sustainability Statement and Policy," Dalhousie University, Nova Scotia, Canada, 2009, which is available at http://office.sustainability.dal.ca/Governance; (2) "Climate Literacy: The Essential Principles of Climate…

  1. The sustainable development

    International Nuclear Information System (INIS)

    2004-01-01

    In the framework of the sustainable development week (june 2003), Actu Environnement published a complete document on the sustainable development to inform the public, recall the main steps of this notion (Rio conference and the following conferences) and the possible employments. It presents also the main organizations acting in the sustainable development domain. (A.L.B.)

  2. Toward sustainable logistics

    NARCIS (Netherlands)

    Soysal, Mehmet; Bloemhof-Ruwaard, Jacqueline M.

    2017-01-01

    The fast evolution of sustainability leads to the development of a new fast-growing concept called sustainable logistics management. This research addresses recent business trends and challenges in logistics and their implications for sustainable logistics management. Additionally, we discuss policy

  3. Toward sustainable logistics

    NARCIS (Netherlands)

    Soysal, Mehmet; Bloemhof-Ruwaard, Jacqueline M.

    2018-01-01

    The fast evolution of sustainability leads to the development of a new fast-growing concept called sustainable logistics management. This research addresses recent business trends and challenges in logistics and their implications for sustainable logistics management. Additionally, we discuss policy

  4. Sustainable Learning Organizations

    Science.gov (United States)

    Velazquez, Luis E.; Esquer, Javier; Munguia, Nora E.; Moure-Eraso, Rafael

    2011-01-01

    Purpose: The purpose of this paper is to debate how companies may better become a sustainable learning organization by offering the most used and insightful concepts of sustainability. Design/methodology/approach: Through literature review, learning organization and sustainability perspectives are explored and compared. Findings: Learning…

  5. Sustainability Annual Report 2013

    OpenAIRE

    2013-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  6. Sustainability Annual Report 2014

    OpenAIRE

    2014-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  7. Sustainability Annual Report 2017

    OpenAIRE

    2017-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  8. Sustainability Annual Report 2011

    OpenAIRE

    2011-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  9. Sustainability Annual Report 2012

    OpenAIRE

    2012-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  10. Sustainability Annual Report 2015

    OpenAIRE

    2015-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  11. Sustainability Annual Report 2016

    OpenAIRE

    2016-01-01

    Every year, Virginia Tech releases a sustainability annual report to show the university’s progress in meeting the sustainability goals. The key sustainability metrics these reports cover include: greenhouse gas (GHG) emissions, energy use intensity, alternative transportation use, recycling, and water consumption.

  12. Sustainable cities and energy policies

    International Nuclear Information System (INIS)

    Capello, R.; Nijkamp, P.; Pepping, G.

    1999-01-01

    This book starts out with the optimistic perspective that modern cities can indeed play a strategic role in the necessary pathway to sustainable development, with particular emphasis on the opportunities offered by local energy and environmental initiatives. Our study aims to demonstrate that an urban sustainability policy has many socio-economic benefits, while it also seeks to identify the critical success and failure factors of sustainable city innovations. After a comprehensive review of various opportunities and experiences, attention is focused particularly on renewable energy resources which may offer new potential for the active involvement of local authorities. The study also highlights major impediments regarding the adoption and implementation of renewable energies, in particular, the development of advanced energy-environmental technology in a world dominated by natural (public) monopolies and/or monopolistic competition elements. In this context both theoretical and empirical elements are discussed, as well as institutional aspects. The theory and methodology is tested by a thorough empirical investigation into local renewable energy initiatives in three European countries, viz. Greece, Italy and The Netherlands. Based on an extensive data base, various statistical models are estimated in order to identify the key elements and major driving forces of sustainable development at the city level. And finally, the study is concluded with a long list of applicable and operational policy guidelines for urban sustainability. These lessons are largely based on meta-analytic comparative studies of the various initiatives investigated. (orig.)

  13. COMPETITIVENESS FOR SUSTAINABLE ECONOMIES

    Directory of Open Access Journals (Sweden)

    Nelu Eugen POPESCU

    2014-04-01

    Full Text Available The current economic environment puts pressure on all national economies which struggle to improve their competitiveness and innovativeness in a sustainable way. This article aims to present the current state of the competitiveness by reviewing the main literature and worldwide researches, in order to provide a brief overview of the determinants that drive productivity and economic success at global and national level, taking into consideration the entrepreneurial activity for a country’s competitiveness and economic growth. The paper identifies the ways in which efficiency driven countries can improve their policies and get a better return on their investments, underlining a set of competitiveness enhancing policies (measures that can be implemented by public and private institutions in order to strengthen the economic fundamentals of the economies.

  14. Energy and sustainability

    International Nuclear Information System (INIS)

    Brunner, D.

    2001-01-01

    This article describes the further education concepts of the Swiss Federal Government and the Swiss Cantons in the energy area with particular emphasis on post-graduate courses on energy and sustainability in building and civil engineering. The activities of a working group on further education in these areas and the basic objectives of the concepts in the planning, implementation and operational areas are discussed. The courses offered by various Swiss technical colleges in the building and energy areas are examined and experience gained within the framework of the Swiss 'Energy 2000' programme is discussed. Finally, the Penta Project on renewable energy sources, set up jointly by the SwissEnergy programme and various professional associations to provide further education and training for target audiences in the energy and building technical services areas, is looked at

  15. Life Cycle Sustainability Dashboard

    DEFF Research Database (Denmark)

    Traverso, Marzia; Finkbeiner, Matthias; Jørgensen, Andreas

    2012-01-01

    One method to assess the sustainability performance of products is life cycle sustainability assessment (LCSA), which assesses product performance considering the environmental,economic, and social dimensions of the life cycle. The results of LCSA can be used to compare different products...... of sustainability is the communicability of the results by means of a graphical representation (a cartogram), characterized by a suitable chromatic scale and ranking score. The integration of LCSA and the dashboard of sustainability into a so-called Life Cycle Sustainability Dashboard (LCSD) is described here...

  16. LCA and Sustainability

    DEFF Research Database (Denmark)

    Moltesen, Andreas; Bjørn, Anders

    2018-01-01

    LCA is often presented as a sustainability assessment tool. This chapter analyses the relationship between LCA and sustainability. This is done by first outlining the history of the sustainability concept, which gained momentum with the Brundtland Commission’s report ‘Our Common Future report...... is then demonstrated, and the strategy of LCA to achieving environmental protection, namely to guide the reduction of environmental impacts per delivery of a function, is explained. The attempt to broaden the scope of LCA, beyond environmental protection, by so-called life cycle sustainability assessment (LCSA......) is outlined. Finally, the limitations of LCA in guiding a sustainable development are discussed....

  17. The Sustainability Cycle and Loop: models for a more unified understanding of sustainability.

    Science.gov (United States)

    Hay, Laura; Duffy, Alex; Whitfield, R I

    2014-01-15

    In spite of the considerable research on sustainability, reports suggest that we are barely any closer to a more sustainable society. As such, there is an urgent need to improve the effectiveness of human efforts towards sustainability. A clearer and more unified understanding of sustainability among different people and sectors could help to facilitate this. This paper presents the results of an inductive literature investigation, aiming to develop models to explain the nature of sustainability in the Earth system, and how humans can effectively strive for it. The major contributions are two general and complementary models, that may be applied in any context to provide a common basis for understanding sustainability: the Sustainability Cycle (S-Cycle), and the Sustainability Loop (S-Loop). Literature spanning multiple sectors is examined from the perspective of three concepts, emerging as significant in relation to our aim. Systems are shown to provide the context for human action towards sustainability, and the nature of the Earth system and its sub-systems is explored. Activities are outlined as a fundamental target that humans need to sustain, since they produce the entities both needed and desired by society. The basic behaviour of activities operating in the Earth system is outlined. Finally, knowledge is positioned as the driver of human action towards sustainability, and the key components of knowledge involved are examined. The S-Cycle and S-Loop models are developed via a process of induction from the reviewed literature. The S-Cycle describes the operation of activities in a system from the perspective of sustainability. The sustainability of activities in a system depends upon the availability of resources, and the availability of resources depends upon the rate that activities consume and produce them. Humans may intervene in these dynamics via an iterative process of interpretation and action, described in the S-Loop model. The models are briefly

  18. Fur and Sustainability

    DEFF Research Database (Denmark)

    Skjold, Else; Csaba, Fabian

    2016-01-01

    This paper explores the notion of deeper luxury, which insists that 'real' luxury should involve sustainable practices in the production and consumption of luxury goods. It traces historical and recent developments in the field of fur, to understand the implications, uncertainties and ambiguities...... of luxury’s confrontation with sustainability. Considering fur in relation to future standards for luxury products, we raise questions about moral problematisation and justification of luxury in terms of sustainability. We first examine the encounter of luxury with sustainability and explain...... the significance of the notion of ‘deeper luxury’. After taking stock of the impact of sustainability on luxury and various directions in which sustainable luxury is evolving, we discuss concepts of sustainable development in relation to the history of moral problematisation of luxury. This leads to the case...

  19. Sustainability index for Taipei

    International Nuclear Information System (INIS)

    Lee, Y.-J.; Huang Chingming

    2007-01-01

    Sustainability indicators are an effective means of determining whether a city is moving towards sustainable development (SD). After considering the characteristics of Taipei, Taiwan, discussions with experts, scholars and government departments and an exhaustive literature review, this study selected 51 sustainability indicators corresponding to the socio-economic characteristic of Taipei City. Such indicators should be regarded as a basis for assessing SD in Taipei City. The 51 indicators are classified into economic, social, environmental and institutional dimensions. Furthermore, statistical data is adopted to identify the trend of SD from 1994 to 2004. Moreover, the sustainability index is calculated for the four dimensions and for Taipei as a whole. Analysis results demonstrate that social and environmental indicators are moving towards SD, while economic and institutional dimensions are performing relatively poorly. However, since 2002, the economic sustainability index has gradually moved towards SD. Overall, the Taipei sustainability index indicates a gradual trend towards sustainable development during the past 11 years

  20. Sustainability and Entrepreneurial Action

    DEFF Research Database (Denmark)

    Korsgaard, Steffen T.; Anderson, Alistair

    Abstract Objectives - This paper explores how entrepreneurial action can lead to environmental sustainability. It builds on the assumption that the creation of sustainble practices is one of the most important challenges facing the global society, and that entrepreneurial action is a vital......: resource oriented sustainable entrepreneurial action.  Approach - The paper uses a case study approach to build deeper theoretical knowledge of environmentally sustainable entrepreneurship.  Results - The paper identifies and analyses a distinct form of sustainable entrepreneurship -  resource oriented...... entrepreneurship - which uses bricolage in various ways to create sustainable solutions. Implications and value - The concept of resource oriented sustainable entrepreneurship contributes to the theoretical understanding of how entrepreneurial action can support sustainability, Furthermore the case study has...

  1. Health and sustainability.

    Science.gov (United States)

    Kjӕrgård, Bente; Land, Birgit; Bransholm Pedersen, Kirsten

    2014-09-01

    In the present article, we explore how sustainable development strategies and health promotion strategies can be bridged. The concept of the 'duality of structure' is taken as our starting point for understanding the linkages between health promotion and sustainable development, and for uncovering the structural properties or conditions which either enable or constrain sustainable public health initiatives. We argue that strategies towards health promotion are not sufficiently integrated with strategies for sustainable development, and thus political strategies aimed at solving health problems or sustainability problems may cause new, undesired and unforeseen environmental or health problems. First, we explore how the relation between health and sustainability is articulated in international policy documents. Next, we develop a model for understanding the relation between health promotion and sustainability. Third, we use examples from agriculture and food production to illustrate that health and sustainability are mutually enabling and constraining. We conclude that while the renewed focus on food security and food inequalities has brought the health and sustainability dimensions of the food system onto the political agenda, the conceptualization of duality between health and sustainability could be a new platform for a critical and theoretical stance towards the market-oriented food system strategy. Thinking along the lines of duality means that the integration of health promotion strategies and sustainable development strategies cannot be based on an approach to integration in which either health or sustainability is given precedence over the other. From a duality perspective, integration means conceiving sustainability from a health perspective and health from a sustainability perspective. © The Author (2013). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. Traditional formwork system sustainability performance: experts’ opinion

    Science.gov (United States)

    Taher Al-ashwal, Mohammed; Abdullah, Redzuan; Zakaria, Rozana

    2017-11-01

    The traditional formwork system is one of the commonly used systems in concrete construction. It is considered as one of the least observed activities in term of sustainability performance. In this paper, the sustainability performance of the traditional formwork has been assessed by using a multi-criteria assessment tool to facilitate the decision on the sustainability performance measurement. A quantitative five Likert scale survey study using judgemental sampling is employed in this study. A sample of 93 of engineering construction experts, with different fields including contractors, developers, and consultants in the Malaysian context has made the body of the collected primary data. The results show variety in the distribution of the respondents’ working experience. The sustainability performance is considered moderately sustainable by the experts with only given 40.24 % of the overall total score for the three sustainable categories namely environmental, social and economic. Despite the finding that shows that the economic pillar was rated as the most sustainable aspect in comparison to the environmental and social pillars the traditional formwork system sustainability still needs enhancement. Further incorporation of the social and environmental pillars into the concrete construction the sustainability performance of traditional formwork system could be improved.

  3. Sustainable development and energy resources

    International Nuclear Information System (INIS)

    Steeg, H.

    2000-01-01

    (a) The paper describes the substance and content of sustainability as well as the elements, which determine the objective. Sustainability is high on national and international political agendas. The objective is of a long term nature. The focus of the paper is on hydrocarbon emissions (CO 2 ); (b) International approaches and policies are addressed such as the Climate change convention and the Kyoto protocol. The burden for change on the energy sector to achieve sustainability is very large in particular for OECD countries and those of central and Eastern Europe. Scepticism is expresses whether the goals of the protocol and be reached within the foreseen timeframe although governments and industry are active in improving sustainability; (c) Future Trends of demand and supply examines briefly the growth in primary energy demand as well as the reserve situation for oil, gas and coal. Renewable energy resources are also assessed in regard to their future potential, which is not sufficient to replace hydrocarbons soon. Nuclear power although not emitting CO 2 is faced with grave acceptability reactions. Nevertheless sustainability is not threatened by lack of resources; (d) Energy efficiency and new technologies are examined vis-a-vis their contribution to sustainability as well as a warning to overestimate soon results for market penetration; (e) The impact of liberalization of energy sectors play an important role. The message is not to revert back to command and control economies but rather use the driving force of competition. It does not mean to renounce government energy policies but to change their radius to more market oriented approaches; (f) Conclusions centre on the plea that all options should be available without emotional and politicized prejudices. (author)

  4. Sustainable development and energy resources

    International Nuclear Information System (INIS)

    Steeg, H

    2002-01-01

    (a) The paper describes the substance and content of sustainability as well as the elements, which determine the objective. Sustainability is high on national and international political agendas. The objective is of a long term nature. The focus of the paper is on hydrocarbon emissions (CO 2 ); (b) International approaches and policies are addressed such as the climate change convention and the Kyoto protocol. The burden for change on the energy sector to achieve sustainability is very large in particular for OECD countries and those of central and Eastern Europe. Scepticism is expresses whether the goals of the protocol and be reached within the foreseen timeframe although governments and industry are active in improving sustainability; (c) Future trends of demand and supply examines briefly the growth in primary energy demand as well as the reserve situation for oil, gas and coal. Renewable energy resources are also assessed in regard to their future potential, which is not sufficient to replace hydrocarbons soon. Nuclear power although not emitting CO 2 is faced with grave acceptability reactions. Nevertheless sustainability is not threatened by lack of resources; (d) Energy efficiency and new technologies are examined vis-a-vis their contribution to sustainability as well as a warning to overestimate soon results for market penetration; (e) The impact of liberalization of energy sectors play an important role. The message is not to revert back to command and control economies but rather use the driving force of competition. It does not mean to renounce government energy policies but to change their radius to more market oriented approaches; (f) Conclusions centre on the plea that all options should be available without emotional and politicized prejudices. (author)

  5. Sustainable Enterprise Excellence and the Continuously Relevant and Responsible Organization

    DEFF Research Database (Denmark)

    Edgeman, Rick; Bøllingtoft, Anne; Eskildsen, Jacob Kjær

    2013-01-01

    Innovation and sustainability are critical to the design, activities, results, and financial viability of organizations. These support one another, with “sustainable innovation” addressing economic sustainability, and “innovating for sustainability” addressing societal and environmental...... sustainability. Both sustainable innovation and innovation for sustainability have gained traction as partial means of confronting economic, environmental and societal challenges. Although garnering footholds is promising, the growth rate of these challenges has thus far exceeded trajectory, scale, and velocity...... issues surrounding enterprise innovation and sustainability efforts and capabilities. Innovation and sustainability of the necessary trajectory, scale, and velocity are strategically integrated to deliver what we refer to as innovating sustainability. This provides an accelerated means path toward...

  6. The NRNU MEPhI activities in the development and applications of advanced tools for innovative nuclear energy systems sustainability assessments - 5020

    International Nuclear Information System (INIS)

    Andrianov, A.; Dogov, A.; Kuptsov, I.; Fedorova, E.; Svetlichnyy, L.; Utianskaia, T.; Korovin, Y.

    2015-01-01

    This report delineates the multi-objective optimization and uncertainty treatment modules for the IAEA energy planning software MESSAGE developed at the National Research Nuclear University MEPhI and the Obninsk Institute for Nuclear Power Engineering intended for multi-objective optimization and sustainability assessments of innovative nuclear energy systems with account of uncertainty. The authors present some results of implementation of these tools for multi-objective nuclear energy system optimization studies. The developed software allows searching for compromises between the conflicting factors that determine the nuclear energy systems' effectiveness and calculating corresponding trade-off rates; carrying out comparative multi-criteria analysis of alternatives as well as choosing, ranking, and sorting corresponding options taking into account the evolution dynamics, structure and organization of a nuclear fuel cycle and the most important system constraints and restrictions. (authors)

  7. SMART SUSTAINABLE ISLANDS VS SMART SUSTAINABLE CITIES

    Directory of Open Access Journals (Sweden)

    D. N. Pantazis

    2017-09-01

    Full Text Available This paper has several aims: a the presentation of a critical analysis of the terms “smart sustainable cities” and “smart sustainable islands” b the presentation of a number of principles towards to the development methodological framework of concepts and actions, in a form of a manual and actions guide, for the smartification and sustainability of islands. This kind of master plan is divided in thematic sectors (key factors which concern the insular municipalities c the creation of an island’s smartification and sustainability index d the first steps towards the creation of a portal for the presentation of our smartification actions manual, together with relative resources, smart applications examples, and, in the near future the first results of our index application in a number of Greek islands and e the presentation of some proposals of possible actions towards their sustainable development and smartification for the municipalities - islands of Paros and Antiparos in Greece, as case studies.

  8. Health and Sustainability

    DEFF Research Database (Denmark)

    Land, Birgit; Pedersen, Kirsten Bransholm; Kjærgård, Bente

    2014-01-01

    In the present article, we explore how sustainable development strategies and health promotion strategies can be bridged. The concept of the ‘duality of structure’ is taken as our starting point for understanding the linkages between health promotion and sustainable development, and for uncovering...... the structural properties or conditions which either enable or constrain sustainable public health initiatives. We argue that strategies towards health promotion are not sufficiently integrated with strategies for sustainable development, and thus political strategies aimed at solving health problems...... or sustainability problems may cause new, undesired and unforeseen environmental or health problems. First, we explore how the relation between health and sustainability is articulated in international policy documents. Next, we develop a model for understanding the relation between health promotion...

  9. ICT innovations for sustainability

    CERN Document Server

    Aebischer, Bernard

    2015-01-01

    ICT Innovations for Sustainability is an investigation of how information and communication technology can contribute to sustainable development. It presents clear definitions of sustainability, suggesting conceptual frameworks for the positive and negative effects of ICT on sustainable development. It reviews methods of assessing the direct and indirect impact of ICT systems on energy and materials demand, and examines the results of such assessments. In addition, it investigates ICT-based approaches to supporting sustainable patterns of production and consumption, analyzing them at various levels of abstraction – from end-user devices, Internet infrastructure, user behavior, and social practices to macro-economic indicators.   Combining approaches from Computer Science, Information Systems, Human-Computer Interaction, Economics, and Environmental Sciences, the book presents a new, holistic perspective on ICT for Sustainability (ICT4S). It is an indispensable resource for anyone working in the area of ICT...

  10. Engineering students' sustainability approaches

    Science.gov (United States)

    Haase, S.

    2014-05-01

    Sustainability issues are increasingly important in engineering work all over the world. This article explores systematic differences in self-assessed competencies, interests, importance, engagement and practices of newly enrolled engineering students in Denmark in relation to environmental and non-environmental sustainability issues. The empirical base of the article is a nation-wide, web-based survey sent to all newly enrolled engineering students in Denmark commencing their education in the fall term 2010. The response rate was 46%. The survey focused on a variety of different aspects of what can be conceived as sustainability. By means of cluster analysis, three engineering student approaches to sustainability are identified and described. The article provides knowledge on the different prerequisites of engineering students in relation to the role of sustainability in engineering. This information is important input to educators trying to target new engineering students and contribute to the provision of engineers equipped to meet sustainability challenges.

  11. Sustainable Concrete Technology

    Directory of Open Access Journals (Sweden)

    Sim J.

    2015-12-01

    Full Text Available The growing concern over global warming and significant ecological changes requires sustainable development in all fields of science and technology. Concrete not only consumes huge amount of energy and natural sources, but also emits large amount of CO2, mainly due to the production of cement. It is evident that such large amount of concrete production has put significant impact on the energy, resource, environment, and ecology of the society. Hence, how to develop the concrete technology in a sustainable way has become a significant issue. In this paper, some of Korean researches for sustainable development of concrete are presented. These are sustainable strengthening for deteriorated concrete structure, sustainable reinforcement of new concrete structure, sustainable concrete using recycled aggregate and supplementary cementing materials and finally application of each technique to precast concrete.

  12. Sustainable Housing Design

    DEFF Research Database (Denmark)

    Lauring, Gert Michael

    2016-01-01

    Sustainable Housing Design. Integrating technical and housing quality aspects of sustainable architecture in civil engineering education. Summary An integrated design approach to sustainable architecture is outlined that combines concerns for zero energy building, good indoor climate and adequate...... phases. The outcome shows that integrated design further solutions where sustainable urban forms of settlement can be highly energy efficient while also attractive from a user perspective. Key words: Sustainable architecture, integrated design, zero-energy-housing, dense urban living. 1. Introduction...... When designing sustainable housing, energy optimization and satisfactory indoor climates are central issues that need to be incorporated from early design phases if to reach a coherent design. It might also be argued that the energy consumption of contemporary buildings only plays a rela-tively minor...

  13. Is Mass Customization Sustainable?

    DEFF Research Database (Denmark)

    Petersen, Thomas Ditlev; Jørgensen, Kaj Asbjørn; Nielsen, Kjeld

    2011-01-01

    Mass customizers are like other companies currently experiencing an increasing customer demand for environmentally sustainable products as well as an increasingly strict legislation regarding environmental sustainability. This paper addresses the issue whether the concepts mass customization...... and sustainability are fundamentally compatible by asking the question: can a mass customized product be sustainable? Several factors could indicate that mass customized products are less sustainable than standardized products; however other factors suggest the opposite. This paper explores these factors during...... three life cycle phases for a product: Production, Use and End of Life. It is concluded that there is not an unambiguous causal relationship between mass customization and sustainability; however several factors unique to mass customized products are essential to consider during product and process...

  14. Motivations Behind Sustainable Purchasing

    OpenAIRE

    Vörösmarty, Gyöngyi; Dobos, Imre; Tátrai, Tünde

    2011-01-01

    Sustainability issues in purchasing are receiving greater attention. Literature is rapidly growing, with several research programs being initiated to investigate the topic. This study presents the results of a research project which aims to reveal and structure the motivating forces leading companies to make efforts in sustainability purchasing and the means used to attain achievements in some fields of sustainability. Results presented in the literature are scattered in terms of ...

  15. Monitor Sustainable Netherlands 2011

    International Nuclear Information System (INIS)

    2011-09-01

    The Monitor provides an image of the sustainability of the Dutch society. It shows which areas are successful and what the 'concerns for tomorrow' are from the point of view of sustainability. An analysis is conducted of how the Netherlands are doing in the fields of climate change, biodiversity, health, knowledge, graying and social cohesion. These and many other topics are discussed in this monitor by means of a number of sustainability indicators and detail analyses [mk]. [nl

  16. Monitor Sustainable Netherlands 2009

    International Nuclear Information System (INIS)

    2009-02-01

    The Monitor provides an image of the sustainability of the Dutch society. It shows which areas are successful and what the 'concerns for tomorrow' are from the point of view of sustainability. An analysis is conducted of how the Netherlands are doing in the fields of climate change, biodiversity, health, knowledge, graying and social cohesion. These and many other topics are discussed in this monitor by means of a number of sustainability indicators and detail analyses [mk] [nl

  17. Managing Supplier Sustainability Risk

    OpenAIRE

    Harilainen, Hanna-Riitta

    2014-01-01

    Supply chains are increasingly global, often reaching to developing regions. The media pressure brand owners to be responsible, but a product is only as sustainable as the practices of all the companies involved in manufacturing it are. It’s not enough that the brand owner acts responsibly; sustainable practices have to reach component and raw material suppliers upstream. Image risk has often been recognized as reason for investing in sustainability. In the supply chain context, supplier m...

  18. Towards a Sustainable Architecture

    OpenAIRE

    Patuel Chust, Pascual

    2014-01-01

    The growing awareness of the importance of ecology in the last decades has led many architects to rethink their construction proposals to make them more respectful of the environment and sustainability. The present article analyzes the legislation, conferences and international declarations (Earth Summit, Declaration of Interdependence for a Sustainable Future, Introduction to Sustainable Design) that have advocated the practice of a more ecological architecture. Also examined ...

  19. Sustainable Management of Food

    Science.gov (United States)

    To provide information to organizations to help them implement sustainable food management, including joining the Food Recovery Challenge. To provide education and information to communities and concerned citizens.

  20. Sustainable wireless networks

    CERN Document Server

    Zheng, Zhongming; Xuemin

    2013-01-01

    This brief focuses on network planning and resource allocation by jointly considering cost and energy sustainability in wireless networks with sustainable energy. The characteristics of green energy and investigating existing energy-efficient green approaches for wireless networks with sustainable energy is covered in the first part of this brief. The book then addresses the random availability and capacity of the energy supply. The authors explore how to maximize the energy sustainability of the network and minimize the failure probability that the mesh access points (APs) could deplete their

  1. Action Research for Sustainability

    DEFF Research Database (Denmark)

    Egmose, Jonas

    on urban sustainability the need to move towards sustainability at societal level is conceptualised as a democratic challenge questioning the way we live on planet earth. By understanding sustainability as an immanent and emergent ability of ecological and social life, continuously to renew itself without...... with a greater say in the future of urban sustainability research, the work shows how action research can make important methodological contributions to processes of social learning between citizens and scientists by enabling free spaces in peoples everyday life and within academia, where aspects...

  2. Action Research for Sustainability

    DEFF Research Database (Denmark)

    Egmose, Jonas

    by analysing processes of social learning. The book addresses the need to move towards sustainability at societal level as a democratic challenge questioning the way we live on planet earth. By conceptualising sustain-ability as an immanent and emergent ability of ecological and social life, continuously...... to provide local citizens with a greater say in the future of urban sustainability research, this book shows how action research can make important methodological contributions to processes of social learning between citizens and scientists by enabling free spaces in peoples everyday life and within academia...

  3. Integrating sustainability in Engineering Education in Denmark

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik; Valderrama Pineda, Andres Felipe; Remmen, Arne

    2013-01-01

    How to include sustainability in engineering education is currently the main concern among engineering educators. In one way or another, engineering educators are increasingly addressing sustainability issues in the courses they teach, the programs they design and run, the institutional activities...... to be a broader social concern to be taken across programs or eventually in specialised new professional endeavours? To further this discussion, in the second part of this paper we examine how environmental, energy and sustainability we will present some details of the design of the Master Engineering programs...... on Sustainable Cities and Sustainable Design at Aalborg University in Denmark. These programs claim to have developed effective strategies for educating robust engineers capable of dealing with the complexities of the needed calculations and the modelling of physical processes and at the same time able to cope...

  4. Sustaining Exploration in Mature Basins

    International Nuclear Information System (INIS)

    Bayo, A.

    2002-01-01

    Exploration is a business like any other business driven by opportunity, resources and expectation of profit. Therefore, exploration will thrive anywhere the opportunities are significant, the resources are available and the outlook for profit (or value creation) is good. To sustain exploration activities anywhere, irrespective of the environment, there must be good understanding of the drivers of these key investment criteria. This paper will examine these investment criteria as they relate to exploration business and address the peculiarity of exploration in mature basin. Mature basins are unique environment that lends themselves a mix of fears, paradigms and realities, particularly with respect to the perception of value. To sustain exploration activities in a mature basin, we need to understand these perceptions relative to the true drivers of profitability. Exploration in the mature basins can be as profitable as exploration in emerging basins if the dynamics of value definition-strategic and fiscal values are understood by operators, regulators and co ventures alike. Some suggestions are made in this presentation on what needs to be done in addressing these dynamic investment parameters and sustaining exploration activities in mature basins

  5. Corporate Social Responsibility for Sustainability

    Directory of Open Access Journals (Sweden)

    Wojciech Przychodzeń

    2014-06-01

    Full Text Available Purpose: The purpose of this paper is to is to provide insights on implementing corporate social responsibility for sustainability (CSRS concept and show how it differs from basic corporate social responsibility (CSR. Methodology: The paper discusses major issues with references to existing literature and real business cases from S&P500 consumer discretionary sector. Findings: The main fi nding of this paper is that CSRS could provide the company with a competitive advantage as a growing number of consumers become more sustainable conscious. It could also help to overcome the increasing consumers’ skepticism towards corporate social responsibility practices. Finally, it can also be seen as a step forward in defi ning what types of corporate activities are associated with desirable social and environmental gains. Research limitations: Our sample was restricted to the U.S. fi rms from the consumer discretionary sector. Therefore, conclusions should not be generalized to other markets. Our study is based on the analysis of environmental and social responsibility statements and assumes that they accurately represent corporate commitment in majority of the cases. Practical implications: CSRS offers corporations the opportunity to use their unique skills, culture, values, resources, and management capabilities to lead social progress by making sustainability part of its internal corporate logic. Originality: The paper raises the importance of the different conditions necessary for making sustainable development concept an important part of corporate strategy.

  6. Sustainable housing as part of sustainable development - visions and experiences from Denmark

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard

    2010-01-01

    The paper discusses different approaches to sustainable development with main focus on sustainable housing, but also local climate activities with focus on transportation, food and local businesses are discussed. The focus in the paper is mainly on experiences from Denmark. The paper starts out...... with a short introduction to theoretical approaches to analyses of sustainable housing and other sustainability initiatives as innovation processes. Afterwards some social and political characteristics of Denmark are presented and one of the recent sustainability initiatives in Denmark, the climate plan from...... the Danish Society of Engineers is described. The second part of the paper discusses Danish sustainable housing strategies focusing on new houses and refurbishment of existing houses. Finally some recent experiences from a local climate cooperation between a technical university, a municipal administration...

  7. Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice

    NARCIS (Netherlands)

    Korsheninnikova, E.; van der Zon, G. C. M.; Voshol, P. J.; Janssen, G. M.; Havekes, L. M.; Grefhorst, A.; Kuipers, F.; Reijngoud, D. -J.; Romijn, J. A.; Ouwens, D. M.; Maassen, J. A.

    2006-01-01

    Aims/hypothesis Activation of nutrient sensing through mammalian target of rapamycin (mTOR) has been linked to the pathogenesis of insulin resistance. We examined activation of mTOR-signalling in relation to insulin resistance and hepatic steatosis in mice. Materials and methods Chronic hepatic

  8. Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice

    NARCIS (Netherlands)

    Korsheninnikova, E.; van der Zon, G. C. M.; Voshol, P. J.; Janssen, G. M.; Havekes, L. M.; Grefhorst, A.; Kuipers, F.; Reijngoud, D.-J.; Romijn, J. A.; Ouwens, D. M.; Maassen, J. A.

    2006-01-01

    Activation of nutrient sensing through mammalian target of rapamycin (mTOR) has been linked to the pathogenesis of insulin resistance. We examined activation of mTOR-signalling in relation to insulin resistance and hepatic steatosis in mice. Chronic hepatic steatosis and hepatic insulin resistance

  9. Sustainability Assessment and Reporting in Agriculture Sector

    Directory of Open Access Journals (Sweden)

    Edward Kassem

    2017-01-01

    Full Text Available Sustainability assessment is a mainstream business activity that demonstrates the link between the organization’s strategy and commitment to a sustainable global economy. Sustainability indicators describe the environmental, social, economic and governance performance of Small and Medium‑sized Businesses/Enterprises (SMB/SME. Unfortunately, their implementations in the Czech Republic show a low level of engagement in sustainability assessment. The paper presents the results of the authors’ research in sustainability assessment of SMB/SMEs in the agriculture sector of the Czech Republic. An appropriate set of key performance indicators (KPIs in four dimensions (economy, environment, social and governance was developed to suit the SMB/SMEs sustainability assessment in the agriculture sector. A set of KPIs is proposed to help SMB/SMEs to avoid the barriers of sustainability assessment. These indicators are based mainly on Sustainability Assessment of Food and Agriculture, Global Reporting Initiatives Frameworks and on current research state‑of‑the‑art. They have been created following the analysis of a number of agricultural enterprises over the world, particularly within European countries.

  10. PRODUCTION OF PASSION FRUIT SEEDLINGS WITH THE RESIDUE OF AGROINDUSTRIAL PROCESSING OF POTATOES AS A STRATEGY IN THE SUSTAINABILITY OF AGRICULTURAL FAMILY ACTIVITY

    Directory of Open Access Journals (Sweden)

    Leonardo Humberto Silva e Castro

    2012-12-01

    Full Text Available In order to contribute to family farming sustainable development and to the environmental management of the residue generated from potato processing by the company "Bem Brasil Alimentos LTDA" from Araxa, Minas Gerais, Brazil, an experiment was conducted at the Experimental Farm of Araxa (FEAX - EPAMIG between February to April of 2012, aiming to analyze passion fruit seedlings development from the use of different doses of this residue such as substrate, to reduce costs of raw materials. The experiment was conducted in randomized block design with six treatments, four repetitions and 20 plants per plot, being the treatments, blends of soil (latosol with levels of 10%, 20% and 30% of potato processing residue associated to chemical treatment and a witness. After 70 days of sowing, the height of air part (cm, root length (cm, number of leaves and total dry matter (g were evaluated. The best treatment was the M4 which used latosol + chemical treatment + 20% of residue. It was diagnosed that the use of agroindustrial potato processing residue, as part of the substrate, is a favorable alternative for passion fruit seedlings development. Thus, it gives a destination to this residue instead of discarding it into the environment, as well as decreases the costs of raw material that permit its correct ecological use, besides generating more income for family farmers.

  11. Impact of demand of a social tourism in the sustainability of the activity in the locality of El Quisco, Province of San Antonio - Chile

    Directory of Open Access Journals (Sweden)

    Belfor Fernando Portal Valenzuela

    2013-08-01

    Full Text Available Every summer Chile’s Central Coast undergoes the effects of social tourism, as a vast number of low-income visitors arrive from Chile’s most densely populated areas in the Central Zone. Despite congestion and saturation of available touristic resources, the number of visitors increases every year, contravening classic touristic demand models that define migration to less congested resources as the outcome of congestion. This analysis will be focused on El Quisco beach, located at Valparaiso’s Region, a touristic destination that clearly represents this process of mass tourism socialization. The goal of this research is to understand the demand composition that social tourism generates, by determining its nature and identifying the factors that define its behavior. These factors are related to the visitor’s origin, displacement, permanence, loyalty, social bonds, gender, income, consumption capacity, and to the degree of satisfaction regarding touristic supplies such as beaches, equipment, and infrastructure. Understanding this demand behavior it is key to develop policies enabling the planning of sustainable social tourism, and allowing for low-income families to access high-quality resources.

  12. Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes.

    Directory of Open Access Journals (Sweden)

    Aileen J F King

    Full Text Available The activation of the transcription factor NF-κB leads to changes in expression of many genes in pancreatic β-cells. However, the role of NF-κB activation in islet transplantation has not been fully elucidated. The aim of the present study was to investigate whether the state of NF-κB activation would influence the outcome of islet transplantation. Transgenic mice expressing a dominant active IKKβ (constitutively active or a non-degradable form of IκBα (constitutive inhibition under control of the rat insulin promoter were generated. Islets from these mice were transplanted into streptozotocin diabetic mice in suboptimal numbers. Further, the effects of salicylate (an inhibitor of NF-κB treatment of normal islets prior to transplantation, and the effects of salicylate administration to mice prior to and after islet implantation were evaluated. Transplantation outcomes were not affected using islets expressing a non-degradable form of IκBα when compared to wild type controls. However, the transplantation outcomes using islets isolated from mice expressing a constitutively active mutant of NF-κB were marginally worse, although no aberrations of islet function in vitro could be detected. Salicylate treatment of normal islets or mice had no effect on transplantation outcome. The current study draws attention to the complexities of NF-κB in pancreatic beta cells by suggesting that they can adapt with normal or near normal function to both chronic activation and inhibition of this important transcription factor.

  13. Sustainable building organisation

    NARCIS (Netherlands)

    Schmid, P.

    1998-01-01

    Sustainable Development and Sustainable Building is mainly a question of (human) environmentally-conscious Organisation and Management Criteria are needed in order to capture the best practices in the field. Therefore we developed modells and methods, which help to choose the most adequate

  14. At Home with Sustainability

    DEFF Research Database (Denmark)

    Hale, Lara

    2018-01-01

    of default rules in subconscious decision-making, this research finds that, ultimately, awareness drives the demand necessary for the creation of sustainable consumption. Whereas direct appeal to individuals has a disappointing level of influence on sustainability choices, it is understood that green...

  15. Predicting Sustainable Work Behavior

    DEFF Research Database (Denmark)

    Hald, Kim Sundtoft

    2013-01-01

    Sustainable work behavior is an important issue for operations managers – it has implications for most outcomes of OM. This research explores the antecedents of sustainable work behavior. It revisits and extends the sociotechnical model developed by Brown et al. (2000) on predicting safe behavior...

  16. Sustainability in Software Engineering

    NARCIS (Netherlands)

    Wolfram, N.J.E.; Lago, P.; Osborne, Francesco

    2017-01-01

    The intersection between software engineering research and issues related to sustainability and green IT has been the subject of increasing attention. In spite of that, we observe that sustainability is still not clearly defined, or understood, in the field of software engineering. This lack of

  17. Sustainable Agriculture: Cover Cropping

    Science.gov (United States)

    Webster, Megan

    2018-01-01

    Sustainable agriculture practices are increasingly being used by farmers to maintain soil quality, increase biodiversity, and promote production of food that is environmentally safe. There are several types of sustainable agriculture practices such as organic farming, crop rotation, and aquaculture. This lesson plan focuses on the sustainable…

  18. Sustaining Urban Forests

    Science.gov (United States)

    John F. Dwyer; David J. Nowak

    2003-01-01

    The significance of the urban forest resource and the powerful forces for change in the urban environment make sustainability a critical issue in urban forest management. The diversity, connectedness, and dynamics of the urban forest establish the context for management that will determine the sustainability of forest structure, health, functions, and benefits. A...

  19. Engineering Students' Sustainability Approaches

    Science.gov (United States)

    Haase, S.

    2014-01-01

    Sustainability issues are increasingly important in engineering work all over the world. This article explores systematic differences in self-assessed competencies, interests, importance, engagement and practices of newly enrolled engineering students in Denmark in relation to environmental and non-environmental sustainability issues. The…

  20. Thermodynamics and sustainable development

    NARCIS (Netherlands)

    Cornelissen, Rene

    1997-01-01

    It is the objective of this thesis to demonstrate exergy analysis as a powerful instrument to obtain sustainable development. An important aspect of sustainable development is the minimisation of irreversibilities caused by the use of non-renewables. In order to limit the scope of this thesis

  1. Sustainability at BPA 2012

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-12-01

    BPA’s Sustainability Action Plan is grounded in our commitment to environmental stewardship and Executive Order 13514 that calls on the federal agencies to “lead by example” by setting a 2020 greenhouse gas emissions target, increasing energy efficiency; reducing fleet petroleum consumption; conserving water; reducing waste; supporting sustainable communities; and leveraging federal purchasing power to promoting environmentally responsible products and technologies.

  2. Gut microbiota sustains hematopoiesis

    DEFF Research Database (Denmark)

    Theilgaard-Mönch, Kim

    2017-01-01

    In this issue of Blood, Josefsdottir et al provide substantial evidence that commensal gut microbes regulate and sustain normal steady-state hematopoiesis.1......In this issue of Blood, Josefsdottir et al provide substantial evidence that commensal gut microbes regulate and sustain normal steady-state hematopoiesis.1...

  3. Sustainable economic structures

    NARCIS (Netherlands)

    Dellink, R.B.; Bennis, M.; Verbruggen, H.

    1999-01-01

    The paper introduces four scenarios for sustainable economic structures in the Netherlands for 2030. The aim of this paper is to provide possible answers to what a sustainable future might look like in terms of alternative economic structures. To this end, an empirical economy-ecology model is

  4. Leading Sustainability in Schools

    Science.gov (United States)

    Carr, Katie

    2016-01-01

    What is the role of schools, and more specifically school leadership, in the transition to a sustainable future for humankind? What different forms of leadership are needed to enable this role? The challenges are huge and complex and for those of us engaged in promoting sustainability learning, it is clear that the issue has never been more…

  5. Aesthetics of sustainable architecture

    NARCIS (Netherlands)

    Lee, S.; Hill, G.; Sauerbruch, M.; Hutton, L.; Knowles, R.; Bothwell, K.; Brennan, J.; Jauslin, D.; Holzheu, H.; AlSayyad, N.; Arboleda, G.; Bharne, V.; Røstvik, H.; Kuma, K.; Sunikka-Blank, M.; Glaser, M.; Pero, E.; Sjkonsberg, M.; Teuffel, P.; Mangone, G.; Finocchiaro, L.; Hestnes, A.; Briggs, D.; Frampton, K.; Lee, S.

    2011-01-01

    The purpose of this book is to reveal, explore and further the debate on the aesthetic potentials of sustainable architecture and its practice. This book opens a new area of scholarship and discourse in the design and production of sustainable architecture, one that is based in aesthetics. The

  6. QUALITY MILESTONES OF THE SUSTAINABLE TOURISM

    Directory of Open Access Journals (Sweden)

    Tomescu Ada Mirela

    2014-12-01

    Full Text Available At this stage there are numerous studies about how tourism activity is related and affects the environment. The purpose of this paper is to examine theoretically, and to analyse activities that occur in hotels, linking this activity to the principles and activities that reduce the tourism negative environmental impact. When we have the objective to discuss sustainable development we must balance between a trilogies that enclose the following three concepts: economic, social/ equity and ecology/environment. In fact in our opinion we agree that “sustainable development is a fractal” concept. Sustainable development is examined here, specifically - taking account of the activity of accommodation in hotels, and also the frame that such activity must integrates. The principles of sustainable development are the most important factors beside clients` expectations, such that to maintain a standard that not only is high, so the coefficients satisfy tourists, but to suit the requirements sustainability, which in this instance means rationalization repeated on different levels and plans (this concerns to energy consumption, water, to waste disposal, etc.. The relationship between tourism and the environment is particular complex, since these two factors are interrelated, and each of them is, at their turn characterised by complexity and variability. The fundamental premise for a friendly, high quality tourism is harmony on the one hand, with the operators (for sustainable development and secondly with tourists (for a correct use of the facilities. As a syntagma, this can mean: the promotion and adoption of "green behaviour". It is believed today that more and more hoteliers should adopt this behaviour, an ecological framework in which hotel has the benefits of normal economic activity, showing competitiveness, but customer satisfaction in the highest grade (quality remains the central plan in spite of rigors required by the so-called: "green behaviour

  7. Sustaining the wild equals sustaining the world.

    Science.gov (United States)

    Nelson, G

    1994-01-01

    Sustainable development and carrying capacity are concepts that denote meeting society's needs without compromising the survival of future generations. The United States and other industrialized countries are pursuing a self-destructive course when fueling their economies by consuming their capital and degrading and depleting their resource base. Maximum exploitation of all resources has been the guiding ethic without paying respect to the environmental consequences. A sustainable society is still possible if strong political leadership and an ecologically literate society with an environmental ethic evolves. In the 1990s the world's population is calculated to increase to 6.3 billion people, the population of the United States already exceeds its carrying capacity and neither of these population increases are sustainable in the long run. In 1916 the US had 98 million people, and in 1994 it had about 260 million and it is still growing. The consequences are already obvious: the National Park System had just 358,000 visitors in 1916, 33 million in 1950, 172 million in 1970, and over 270 million in 1993. Often economists are an impediment to a sustainable economy because they fail to factor in the accumulated environmental deficit or annual cost of environmental deterioration when measuring annual economic output. Fortunately, in the US a conservation ethic is beginning to develop that will eventually become a strong social, political, and economic force. For instance, Wisconsin has mandated environmental education in every school from kindergarten through 12th grade. Such a program will provide the moral and political support to move the country to a sustainable economy. Even losing nations have recovered from World War II, but there is no recovery from destroyed ecosystems.

  8. ANDRA - National Radioactive Waste Management Agency. Activity report 2009 - Managing today to prepare for tomorrow. Management report and financial statements at December 31, 2009. Annual Sustainable Development Report 2009

    International Nuclear Information System (INIS)

    2010-01-01

    Created in 1979 within the CEA, the National Radioactive Waste Management Agency (ANDRA) was established by the December 1991 Waste Act as a public body in charge of the long-term management of all radioactive waste, under the supervision of the Ministry of Ecology, Energy, Sustainable Development and the Sea (formerly the Ministry of Industry and the Ministry of Environment), and the Ministry of Research. Its 3 basic missions were extended and their funding secured through the 2006 Planning Act: - a R and D mission to propose safe long-term solution for radioactive waste without current disposal system; this mission includes long-term storage, since the 2006 Planning Act, in order to propose interim solutions while final ones are being studied; - an industrial mission concerning, on one hand, waste acceptance criteria and control and, on the other hand, siting, construction, operation, closure and monitoring of repositories. This mission includes as well a public service mission in terms of i) collection of waste of the 'small-scale nuclear activities' producers or owners (including the so-called 'household' radioactive waste, i.e. waste owned by private individuals) and ii) clean-up and rehabilitation of orphan polluted sites; - an information mission, notably through the regular publication of the National Inventory of radioactive materials and waste. This mission includes as well an active policy of dialogue with stakeholders both at national and local level. This document is the activity report, with the management and financial statements report, and the Sustainable Development Report of the Andra for the year 2009

  9. Sustainable nuclear energy dilemma

    Directory of Open Access Journals (Sweden)

    Afgan Naim H.

    2013-01-01

    Full Text Available Sustainable energy development implies the need for the emerging potential energy sources which are not producing adverse effect to the environment. In this respect nuclear energy has gained the complimentary favor to be considered as the potential energy source without degradation of the environment. The sustainability evaluation of the nuclear energy systems has required the special attention to the criteria for the assessment of nuclear energy system before we can make firm justification of the sustainability of nuclear energy systems. In order to demonstrate the sustainability assessment of nuclear energy system this exercise has been devoted to the potential options of nuclear energy development, namely: short term option, medium term option, long term option and classical thermal system option. Criteria with following indicators are introduced in this analysis: nuclear indicator, economic indicator, environment indicator, social indicator... The Sustainability Index is used as the merit for the priority assessment among options under consideration.

  10. The challenge of sustainability

    International Nuclear Information System (INIS)

    Orr, D.W.

    1993-01-01

    This paper discusses sustainability in a world that has changed rapidly. The author suggests that ecological assumptions embedded in communism and capitalism are badly flawed, but the flaws were not apparent when there were fewer than a billion people on earth living at low technology levels. Sustaining the earth's vital signs is a challenge to our perception of time, and the numbers - population, environmental damage, oil consumption, waste disposal - are too large to comprehend easily. There is a global debate about what sustainability means. In fact the challenge of sustainability is 6 different challenges: overcoming the tendency to deny inconvenient realities; establishing accurate indicators of human and ecological health; questions about the kinds of technology necessary to make the transition to sustainability; education; the need for an emotional bond between man and nature; rebuilding the existing democratic institutions. 16 refs

  11. Sustainable built environments

    CERN Document Server

    Haase, Dagmar

    2013-01-01

    Sustainable design is a collective process whereby the built environment achieves unprecedented levels of ecological balance through new and retrofit construction, with the goal of long-term viability and humanization of architecture. Focusing on the environmental context, sustainable design merges the natural, minimum resource conditioning solutions of the past (daylight, solar heat, and natural ventilation) with the innovative technologies of the present.  The desired result is an integrated “intelligent” system that supports individual control with expert negotiation for resource consciousness. International experts in the field address the fundamental questions of sustainable design and landscape management: How should the sustainability of landscapes and buildings be evaluated? Which targets have to be set and which thresholds should not be exceeded? What forms of planning and governance structures exist and to what extent do they further the goals of sustainability?  Gathering 30 peer-reviewed ent...

  12. Agroecology and Sustainable Agriculture

    Directory of Open Access Journals (Sweden)

    Fabio Caporali

    Full Text Available In the framework of the 16th National Meeting of the Italian Ecological Society (“Global Change, Ecological Diversity and Sustainability”, University of Tuscia, Viterbo, 19-22 September 2006, a symposium was devoted to “Agroecology and Sustainable Development”. A major goal of this symposium was to contribute to keeping the dialogue among the experts of the various disciplines alive. Sustainability of agriculture is a challenge for society world wide. Universities and society as a whole have a responsibility in re-examining current perception of nature, of the world and of human society in the light of natural resources depletion, increasing pollution and social inequalities. The urgency to address sustainability issues is increasingly being reflected in the manner in which institutions of higher education around the world are giving priority to the teaching, research and practice of sustainability. The University of Tuscia is involved in international initiatives concerning teaching and research in Agroecology and Sustainable Agriculture.

  13. Sustainability Marketing Commitment

    DEFF Research Database (Denmark)

    Tollin, Karin; Bech Christensen, Lars

    2017-01-01

    sustainability in marketing, processes associated with sustainability marketing commitment, drivers of sustainability marketing at the functional level of marketing, and its organizational context. Using survey data from 269 managers in marketing, covering a broad range of industries in Sweden and Denmark, we...... took a structural modelling approach to examine construct relationships, mediation, and moderation effects. Overall, the findings show that marketing capabilities associated with the innovation of new products, services, and business models constitute a strong driver to leverage sustainability......Corporate sustainability is an important strategy and value orientation for marketing, but scarce research addresses the organizational drivers and barriers to including it in companies’ marketing strategies and processes. The purpose of this study is to determine levels of commitment to corporate...

  14. What is sustainability economics?

    Energy Technology Data Exchange (ETDEWEB)

    Baumgaertner, Stefan [Department of Sustainability Sciences, Leuphana University of Lueneburg (Germany); Department of Economics, Leuphana University of Lueneburg (Germany); Quaas, Martin [Department of Economics, University of Kiel (Germany)

    2010-01-15

    While economists have been contributing to the discussion of various aspects of sustainability for decades, it is just recently that the term 'sustainability economics' was used explicitly in the ecological, environmental, and resource economics community. Yet, the contributions that use the term 'sustainability economics' do not refer to any explicit definition of the term, and are not obviously joined by common or unifying characteristics, such as subject focus, methodology, or institutional background. The question thus arises: what is 'sustainability economics'? In this essay, we systematically define and delineate 'sustainability economics' in terms of its normative foundation, aims, subject matter, ontology, and genuine research agenda. (author)

  15. Sustainability and uncertainty

    DEFF Research Database (Denmark)

    Jensen, Karsten Klint

    2007-01-01

    The widely used concept of sustainability is seldom precisely defined, and its clarification involves making up one's mind about a range of difficult questions. One line of research (bottom-up) takes sustaining a system over time as its starting point and then infers prescriptions from...... this requirement. Another line (top-down) takes an economical interpretation of the Brundtland Commission's suggestion that the present generation's needsatisfaction should not compromise the need-satisfaction of future generations as its starting point. It then measures sustainability at the level of society...... a clarified ethical goal, disagreements can arise. At present we do not know what substitutions will be possible in the future. This uncertainty clearly affects the prescriptions that follow from the measure of sustainability. Consequently, decisions about how to make future agriculture sustainable...

  16. Sustainability of abrasive processes

    DEFF Research Database (Denmark)

    Aurich, J.C.; Linke, B.; Hauschild, Michael Zwicky

    2013-01-01

    , the content of technical presentations in STC G, and the results of a comprehensive literature study. The approach to sustainability includes environmental, social, and economic sustainability in accordance with the definition proposed in the Brundtland Report of the United Nations [156]. The main focus......This paper presents an overview of research on sustainability of abrasive processes. It incorporates results from a round robin study on ‘‘energy-efficiency of abrasive processes’’ which has been carried out within the scientific technical committee ‘‘abrasive processes’’ (STC G) of CIRP...... is on environmental and social sustainability. Economic sustainability will be considered as manufacturing productivity. © 2013 CIRP....

  17. Active citizenship for urban green infrastructure: fostering the diversity and dynamics of citizen contributions through mosaic governance : System dynamics and sustainability

    NARCIS (Netherlands)

    Buijs, Arjen E; Mattijssen, Thomas JM; Van der Jagt, Alexander PN; Ambrose-Oji, Bianca; Andersson, Erik; Elands, Birgit HM; Steen Møller, Maja

    2016-01-01

    Active citizens may contribute to the environmental, social, and institutional resilience of cities. This review discusses how citizen initiatives protect biodiversity hotspots, contribute to social cohesion, institutional innovation, and diversity in urban green space management. Challenges related

  18. Environmental management and sustainable development in Yugoslavia

    International Nuclear Information System (INIS)

    Simic, J.

    2002-01-01

    All problems have happened in Yugoslavia in last decade have not destroyed wishes to work, to invent and create in field of the environmental protection. This statement gives short survey of experiences in field of the environmental protection and sustainable development in Yugoslavia. The main objective is to emphasize the importance of sustainable development with its four components - economic, environmental, social and cultural. Having in mind that environmental protection is not job taker but a job maker that activity must take priority in near and further future. We wish to point very important role of international cooperation on the way of sustainable development on the Balkan. (author)

  19. Sustainable development in agriculture: is it really sustainable?

    International Nuclear Information System (INIS)

    Singh, S.R.K.; Srinivas, K.; Kumar, L.R.; Gupta, H.S.

    2005-01-01

    Indian agriculture has achieved remarkable success in the food grain production due to inception of 'rainbow revolution', which made the country self-sufficient in food production. Sustainable agriculture (SA) is an ongoing process, in which people take actions leading to development of agriculture that meets their current needs without compromising the ability of future generations to meet their needs. It advocates avoiding all those actions, which reduce the ability of future generations to meet out the present generations. It is based on the optimal interaction between clean environment, healthy economy, and vital society by avoiding trade-off of problems to other regions on to the future. Moreover, sustainable agriculture is the function of people's progress and nature's capacity. In fact, SA commits us to considering the long-term effect and to recognize our place within the ecosystem. It encourages a continuous reflection on the implications of human activity on the ecosystem. Empirical evidences shows that in the race of self-sufficiency in food grain production, we compromised a lot on social and environmental fronts. The aftermath of green revolution is not so sustainable as it showed reverse side too, in the form of environmental degradation and ecological imbalances. Such threats have led to the need for promoting sustainable development in agriculture. Due to several unsustainable activities which resulted in resource degradation in the form of top soil loss, ground water depletion and forest degradation. The average soil loss is estimated to be over 16 tonnes/ha/year. The ground water depletion resulted in several blocks as 'grey blocks' and 'dark blocks'. This happened mainly due to increase in number of tube-wells and free supply of electricity making the cost of pumping water very low. Rate of human induced land degradation is very high. Out of total geographical area of 329.0 million ha, 187 million ha (57.0 %) are reported to have degraded, of

  20. A randomised controlled trial and cost-effectiveness evaluation of "booster" interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods

    Directory of Open Access Journals (Sweden)

    Nicholl Jon

    2010-01-01

    Full Text Available Abstract Background Systematic reviews have identified a range of brief interventions which increase physical activity in previously sedentary people. There is an absence of evidence about whether follow up beyond three months can maintain long term physical activity. This study assesses whether it is worth providing motivational interviews, three months after giving initial advice, to those who have become more active. Methods/Design Study candidates (n = 1500 will initially be given an interactive DVD and receive two telephone follow ups at monthly intervals checking on receipt and use of the DVD. Only those that have increased their physical activity after three months (n = 600 will be randomised into the study. These participants will receive either a "mini booster" (n = 200, "full booster" (n = 200 or no booster (n = 200. The "mini booster" consists of two telephone calls one month apart to discuss physical activity and maintenance strategies. The "full booster" consists of a face-to-face meeting with the facilitator at the same intervals. The purpose of these booster sessions is to help the individual maintain their increase in physical activity. Differences in physical activity, quality of life and costs associated with the booster interventions, will be measured three and nine months from randomisation. The research will be conducted in 20 of the most deprived neighbourhoods in Sheffield, which have large, ethnically diverse populations, high levels of economic deprivation, low levels of physical activity, poorer health and shorter life expectancy. Participants will be recruited through general practices and community groups, as well as by postal invitation, to ensure the participation of minority ethnic groups and those with lower levels of literacy. Sheffield City Council and Primary Care Trust fund a range of facilities and activities to promote physical activity and variations in access to these between neighbourhoods will make it

  1. Ingredients for sustained excellence

    International Nuclear Information System (INIS)

    Johnson, A.R.; Alikhan, S.; Steed, R.G.

    1992-01-01

    Point Lepreau, a 680MWe CANDU reactor, has, since startup, been one of the world's best performing reactors. Many of the ingredients for this success can be found at other plants, but Pt Lepreau has found a ''chemistry'' that has sustained its performance at a very high level. Our belief is that this is the result of two major influences: Pt Lepreau is the only nuclear unit in a small utility, all its nuclear expertise exists at the station, and all necessary disciplines can be readily galvanized to solve problems and get work done. The structure of the organization is simple, with station management involvement in day to day activities. This fosters accountability and a natural efficiency that does not need slogans to achieve its purpose. Turning to the factors that have contributed to the station's success, the IAEA's technical exchange visit in July 1990 identified four items ''which are particularly noteworthy since they can be developed and used widely in the nuclear industry to enhance safety and availability. These are: quality assurance applications; the degree to which system engineers are employed; the dedication of skilled resources to and thoroughness of outage planning; and the in-house development of computers to assist directly in the day to day, medium and long term management of the generating station''. (Author)

  2. Ecotourism – model of sustainable tourist development

    Directory of Open Access Journals (Sweden)

    Mirela Stefanica

    2010-12-01

    Full Text Available In the last years, the tendency in the tourism industry was that of return towards nature and towards the authentic cultural values. Among all the forms of tourism, ecotourism distinguishes itself through the strongest connection with the natural and cultural environment, representing the most valuable form of manifestation of sustainable tourism, with the fastest growth rhythm worldwide. Integrated in the sustainable development, ecotourism involves activities that directly contribute to the nature protection and to keeping the old human creations unaltered.

  3. Energy for sustainable development

    International Nuclear Information System (INIS)

    Toepfer, Klaus

    2003-01-01

    Considerations about 'post-Kyoto' targets and other ways to achieve the objectives of the Protocol are critical. Scientific evidence presented by the IPCC in its third assessment in 2002 clearly indicates the need not only to implement the Protocol, but also to agree on further emission reductions in the medium term in order to keep changes in the world's climate at a manageable level. UNEP's Energy Programme addresses the environmental consequences of energy production and use, such as global climate change and local air pollution. UNEP assists decision makers in government and the private sector to make better, more informed energy choices, which fully integrate environmental and social costs. Since UNEP is not an implementing organization, its role as facilitator is core. The majority of UNEP's energy activities link to mitigation - the reduction of greenhouse gas emissions - but these are generally accompanied by broader objectives related to energy and sustainable development. This includes climate change mitigation, but not as the sole objective since many of UNEP's partners in developing countries have more immediate development objectives. UNEP's main programmes are: The Solar and Wind Energy Resource Assessment (SWERA) project, that provides solar and wind resource data and geographic information assessment tools to public and private sector executives who are involved in energy market development; A new Global Environment Facility (GEF) funded programme aiming at promoting industrial energy efficiency through a cleaner production/environmental management system framework. A parallel programme, Energy Management and Performance Related Energy Savings Scheme (EMPRESS), supports energy efficiency efforts in Eastern and Central Europe; The Mediterranean Renewable Energy Programme promotes the financing of renewable energy projects in the Mediterranean basin; The Rural Energy Enterprise Development (REED) seeks to develop new sustainable energy enterprises

  4. Energy for sustainable development

    Energy Technology Data Exchange (ETDEWEB)

    Toepfer, Klaus [United Nations Environment Programme (Kenya)

    2003-09-01

    Considerations about 'post-Kyoto' targets and other ways to achieve the objectives of the Protocol are critical. Scientific evidence presented by the IPCC in its third assessment in 2002 clearly indicates the need not only to implement the Protocol, but also to agree on further emission reductions in the medium term in order to keep changes in the world's climate at a manageable level. UNEP's Energy Programme addresses the environmental consequences of energy production and use, such as global climate change and local air pollution. UNEP assists decision makers in government and the private sector to make better, more informed energy choices, which fully integrate environmental and social costs. Since UNEP is not an implementing organization, its role as facilitator is core. The majority of UNEP's energy activities link to mitigation - the reduction of greenhouse gas emissions - but these are generally accompanied by broader objectives related to energy and sustainable development. This includes climate change mitigation, but not as the sole objective since many of UNEP's partners in developing countries have more immediate development objectives. UNEP's main programmes are: The Solar and Wind Energy Resource Assessment (SWERA) project, that provides solar and wind resource data and geographic information assessment tools to public and private sector executives who are involved in energy market development; A new Global Environment Facility (GEF) funded programme aiming at promoting industrial energy efficiency through a cleaner production/environmental management system framework. A parallel programme, Energy Management and Performance Related Energy Savings Scheme (EMPRESS), supports energy efficiency efforts in Eastern and Central Europe; The Mediterranean Renewable Energy Programme promotes the financing of renewable energy projects in the Mediterranean basin; The Rural Energy Enterprise Development (REED) seeks to develop new

  5. Fibrous nano-silica supported ruthenium (KCC-1/Ru): A sustainable catalyst for the hydrogenolysis of alkanes with good catalytic activity and lifetime

    KAUST Repository

    Fihri, Aziz

    2012-07-06

    We have shown that fibrous nanosilica (KCC-1) can serve as a suitable support for the synthesis of highly dispersed ruthenium (Ru) nanoparticles. The resulting KCC-1/Ru catalyst displayed superior activity for the hydrogenolysis of propane and ethane at atmospheric pressure and at low temperature. The high catalytic activity was due to the formation of Ru-nanoparticles with an active size range (1-4 nm) and the presence of hexagonal-shaped particles with several corners and sharp edges possessing reactive atoms with lowest coordination numbers. The catalyst was stable with an excellent lifetime and no sign of deactivation, even after eight days. This enhanced stability may be due to the fibrous nature of KCC-1 which restricts Ostwald ripening of Ru nanoparticles. © 2012 American Chemical Society.

  6. Interpreting sustainable development

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Over the past decade, the term" sustainable development"has emerged as the principal concept in the development field. The concept emerged in the 1970s and was first promoted in the international environmental and development communities with the publication of the " world conservation strategy"(1980). It was popularized by the Brundtland report, " Our common future"(1987). The Brundtland Commission defined sustainable development as " development which meets the needs of the present, without compromising the sustainability of future generation to meet their own needs". The Earth Summit(1992) established "sustainable development" as the most important policy of the 21st century. Since then, the relationship between development and environment has been widely discussed and sustainabale development is now an important part of the vocabulary of environmental policy research and analysis. In this paper, we begin by tracing the evolution of the concept of sustainable development. Definitions of sustainable development in ecology, economics and sociology are then explored and discussed. This paper also examine the contribution that a broadly-based concept of sustainable development can make: as a goal, an attitude and as a guiding principle for integrating economic development and environmental protection.

  7. Sustainable winegrowing: current perspectives

    Directory of Open Access Journals (Sweden)

    Mariani A

    2015-05-01

    Full Text Available Angela Mariani,1 Antonella Vastola2 1Department of Economic and Legal Studies, University Parthenope, Naples, 2School of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Potenza, Italy Abstract: The winegrowing sector worldwide is strongly committed to improving environmental and social sustainability. The aim of this work, based on a literature review, is to highlight current sustainability perspectives and the related main issues. There is a broad consensus that the challenge to achieve a greater spread of sustainable practices is to enhance environmental and social sustainability while maintaining economic viability. From the producers' point of view, the priority is to bridge the still substantial knowledge gaps in terms of perceived environmental benefits, economic benefits, and costs. Thus, an increased research effort focusing on the costs and benefits of different winegrowing practices and technical assistance with implementation might support their diffusion. Moreover, targeted marketing strategies are needed to: enhance consumers' involvement and their attitude toward sustainable wine; improve understanding and use of sustainable labels and claims; and raise awareness of some environmental credentials of wine packaging, mainly with reference to lightweight glass bottles. Keywords: winegrower, sustainability, wine, consumer, marketing strategies

  8. Sustainability Infused Curriculum

    Science.gov (United States)

    Ibarra, D. L.

    2015-12-01

    The Independent Schools Foundation Academy (ISF) in Hong Kong established a sustainability policy in 2015, which explicitly states, "an experimentally integrated, environmentally and ethically sustainable system of science education and conservation practices based on the 2012 Jeju Declaration of the World Conservation Congress will be implemented through the school". ISF Academy is a private Chinese bilingual school in Hong Kong serving over 1500 students K-12, following the framework and curriculum of the International Baccalaureate Organization (IBO). The strategy behind the implementation of this policy includes: development of a scientific sustainable curriculum that is age appropriate; establish a culture of sustainability within the ISF community and beyond to the wider HK community; install sustainable infrastructure that allows students to learn; and learn first hand sustainable living practices. It is well understood that solutions to the environmental challenges facing Hong Kong and our planet will require multiple disciplines. The current sustainability programs at ISF include: a) a whole school aerobic food waste composting system and organic farming, b) energy consumption monitoring of existing buildings, c) upcoming installation of an air pollution monitoring equipment that will correlate with the AQHI data collected by the Hong Kong government, d) a Renewable Energy Education Center (REEC) that will teach students about RE and also produce solar energy for classroom consumption, and e) student lead environmental group that manages the paper and used cooking oil recycling on campus. The Shuyuan Science and Sustainability faculty work closely with classroom teachers to ensure that the above mentioned projects are incorporated into the curriculum throughout the school. Interdisciplinary units (IDU) of study are being developed that encourage faculty and students to work across subject areas. Projects include Personal Projects, Extended Essays

  9. Utilising the Potential of Design Briefs in Sustainable Packaging Development

    OpenAIRE

    ten Klooster, Roland; de Koeijer, Bjorn

    2016-01-01

    Sustainable considerations in the development of product-packaging combinations require activities on both the strategic and operational level. As part of a company’s vision, the strategic level of development targets the desired implementation of sustainability considerations. The activities of the multidisciplinary teams of marketers, designers and engineers, which specifies the achieved sustainability in finished packaging concepts, largely determines the operational level of product-packa...

  10. Moving to Sustainable Metals. Multifunctional Ligands in Catalytic, Outer Sphere C-H, N-H and O-H Activation

    Energy Technology Data Exchange (ETDEWEB)

    Crabtree, Robert [Yale Univ., New Haven, CT (United States)

    2015-03-03

    Much of our work during this grant period has emphasized green chemistry and sustainability. For example, we were able to convert glycerine, a waste byproduct of biodiesel production, into lactic acid, a compound with numerous applications, notably in the food and cosmetics industry, as well as being a source material for a biodegradable plastic. This work required a catalyst, that ceases to work after a certain lapse of time. We were able to identify the way in which this deactivation occurs by identifying some of the metal catalyst deactivation products. These proved to be multimetallic clusters containing up to six metals and up to 14 hydrogen atoms. Both the catalytic reaction itself and the deactivation structures are novel and unexpected. We have previously proposed that nitrogen heterocycles could be good energy carriers in a low CO2 future world. In another part of our study, we found catalysts for introduction of hydrogen, an energy carrier that is hard to store, into nitrogen heterocycles. The mechanism of this process proved to be unusual in that the catalyst transfers the H2 to the heterocycle in the form of H+ and H-, first transferring the H+ and only then the H-. In a third area of study, some of our compounds, originally prepared for DOE catalysis purposes, also proved useful in hydrocarbon oxidation and in water oxidation. The latter is important in solar-to-fuel work, because, by analogy with natural photosynthesis, the goal of the Yale Solar Group of four PIs is to convert sunlight to hydrogen and oxygen, which requires water splitting catalysts. The catalysts that proved useful mediate the latter reaction: water oxidation to oxygen. In a more technical study, we developed methods for distinguishing the case where catalysis is mediated by a soluble catalyst from cases where catalysis arises from a deposit of finely divided solid. One particular application involved electrocatalysis

  11. Sustained-release progesterone vaginal suppositories 1--development of sustained-release granule--.

    Science.gov (United States)

    Nakayama, Ayako; Sunada, Hisakazu; Okamoto, Hirokazu; Furuhashi, Kaoru; Ohno, Yukiko; Ito, Mikio

    2009-02-01

    Progesterone (P) is an important hormone for the establishment of pregnancy, and its administration is useful for luteal insufficiency. Considering the problems of commercially available oral and injection drugs, hospital-formulated vaginal suppositories are clinically used. However, since the half-life of P suppositories is short, it is difficult to maintain its constant blood concentration. To sustain drug efficacy and prevent side-effects, we are attempting to develop sustained-release suppositories by examining the degree of sustained-release of active ingredients. In this study, we examined the combinations of granulation methods and release systems for the preparation of sustained-release granules of P, and produced 13 types of sustained-release granules. We also examined the diameter, content, and dissolution of each type of granules, and confirmed that the sustained-release of all types of granules was satisfactory. Among the sustained-release granules, we selected granules with a content and a degree of sustained-release suitable for sustained-release suppositories.

  12. NutriLive: an integrated nutritional approach as a sustainable tool to prevent malnutrition in older people and promote active and healthy ageing

    NARCIS (Netherlands)

    Guido Iaccarino; Dr. Harriët Jager-Wittenaar; Annamaria Colao; Tobias Hartman; Regina Roller-Wirnsberger; Helen Griffiths; Amelia Rauter; Maria Soprano; Donatella Tramontano; Edwig Goossens; Maria Rosaria Rusciano; Laura Vuolo; Nidia Braz; Catherine Crola; Carolina Di Somma; Angela Serena Maione; Maddalena Illario; Pietro Campiglia

    2016-01-01

    The present document describes a nutritional approach that is nested in the European Innovation Partnership for Active and Healthy Aging (EIP-AHA) and aims to provide the first common European program translating an integrated approach to nutritional frailty in terms of a multidimensional and

  13. Sympathetic Activity, Assessed by Power Spectral Analysis of Heart Rate Variability, in White-Coat, Masked and Sustained Hypertension Versus True Normotension

    Czech Academy of Sciences Publication Activity Database

    Fagard, R.H.; Stolarz, K.; Kuznetsova, T.; Seidlerová, J.; Tikhonoff, V.; Grodzicki, T.; Nikitin, Y.; Filipovský, J.; Peleška, Jan; Casiglia, E.; Thijs, L.; Staessen, J.A.; Kawecka-Jaszcz, K.

    2007-01-01

    Roč. 25, č. 11 (2007), s. 2280-2285 ISSN 0263-6352 Institutional research plan: CEZ:AV0Z10300504 Keywords : heart rate variability * masked hypertension * power spectral analysis * sympathetic activity * white-coat hypertension Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 4.364, year: 2007

  14. Textiles and clothing sustainability nanotextiles and sustainability

    CERN Document Server

    2017-01-01

    This book highlights the sustainability aspects of textiles and clothing sector in light of nanomaterials and technologies. The invasion of nano in every industrial sector has been important and has made remarkable changes as well as posed new challenges, including the textiles and clothing sector. There is quite a great deal of research happening in terms of nano materials for textiles across the globe, some of which are covered in this book. .

  15. The sustainable development

    International Nuclear Information System (INIS)

    Robreau, Y.; Porcher, P.

    2002-11-01

    This document aims to define the sustainable development concept with a special attention for France and Israel position. The first part recalls the history of the sustainable development from the ''Man and Biosphere'' program of the UNESCO to Rio protocol. Then are described the principles of the sustainable development, the France plans and the France position at Johannesburg conference. The last part is devoted to the Israel position and a short presentation of the consequences of the greenhouse gases on the human health and the environment. (A.L.B.)

  16. Lean maturity, lean sustainability

    DEFF Research Database (Denmark)

    Jørgensen, Frances; Matthiesen, Rikke; Nielsen, Jacob

    2007-01-01

    . A framework for describing levels of lean capability is presented, based on a brief review of the literature and experiences from 12 Danish companies currently implementing lean. Although still in its emerging phase, the framework contributes to both theory and practice by describing developmental stages......Although lean is rapidly growing in popularity, its implementation is far from problem free and companies may experience difficulties sustaining long term success. In this paper, it is suggested that sustainable lean requires attention to both performance improvement and capability development...... that support lean capability development and consequently, lean sustainability....

  17. Sustainable Facilities Management

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Elle, Morten; Hoffmann, Birgitte

    2004-01-01

    The Danish public housing sector has more than 20 years of experience with sustainable facilities management based on user involvement. The paper outlines this development in a historical perspective and gives an analysis of different approaches to sustainable facilities management. The focus...... is on the housing departments and strateies for the management of the use of resources. The research methods used are case studies based on interviews in addition to literature studies. The paper explores lessons to be learned about sustainable facilities management in general, and points to a need for new...

  18. QUALITY MILESTONES OF THE SUSTAINABLE TOURISM

    OpenAIRE

    Tomescu Ada Mirela

    2014-01-01

    At this stage there are numerous studies about how tourism activity is related and affects the environment. The purpose of this paper is to examine theoretically, and to analyse activities that occur in hotels, linking this activity to the principles and activities that reduce the tourism negative environmental impact. When we have the objective to discuss sustainable development we must balance between a trilogies that enclose the following three concepts: economic, social/ equity and ecolog...

  19. Sustainable development - an entrepreneur's view

    International Nuclear Information System (INIS)

    Fahrni, F.

    1995-01-01

    The following topics are dealt with in this paper: prizing the environment, inducing change, getting the right mix, energy and market place, financing sustainable development, trade and sustainable development, managing corporate change, the Sulzer strategy for sustainable development. (author)

  20. Analyse that! : understanding sustainable design

    NARCIS (Netherlands)

    Brand, van den G.J.W.; Wit, de M.H.

    2004-01-01

    This paper describes a method for the analysis of sustainable building projects. Sustainable technology measures can easily be misinterpreted, consequently leading to unsustainable building solutions. Our research and educations aims at discovering new approaches for sustainable design. For building