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Sample records for susceptibility show signs

  1. Characterization and antimicrobial susceptibility of motile aeromonads isolated from freshwater ornamental fish showing signs of septicaemia.

    Science.gov (United States)

    Jagoda, S S S de S; Wijewardana, T G; Arulkanthan, A; Igarashi, Y; Tan, E; Kinoshita, S; Watabe, S; Asakawa, S

    2014-05-13

    A total of 74 phenotypically identified presumptive motile Aeromonas isolates recovered from septicaemic freshwater ornamental fish in Sri Lanka were genetically characterized by sequencing of rpoD and gyrB genes. rpoD/gyrB phylogeny confirmed only 53 isolates as Aeromonas, among which A. veronii was the predominant species (79.2%), followed by A. hydrophila (7.5%), A. caviae (5.7%), A. jandaei (1.9%), A. dhakensis (3.8%) and A. entero pelogenes (1.9%). The aeromonads confirmed by sequencing were further subjected to 16S rDNA PCR-RFLP which substantiated sequencing results for 83% of isolates. Fingerprinting of A. enteropelogenes (n = 42) using ERIC-PCR revealed no dominant clones, and the majority were genetically distinct. All isolates were screened by PCR for 7 virulence determinant genes (aer, act, ast, alt, fla, ser, exu) and 2 integrase encoding genes (intI1, intI2). Each isolate contained ≥3 of the virulence genes tested for, with a heterogeneous distribution. Of the isolates, 77% harboured the intI1 gene, while none had intI2. In vitro antimicrobial susceptibility testing showed highest resistances towards tetracycline (58.5%) and erythromycin (54.7%). Our results indicate the diverse range of aeromonads that could potentially be associated with motile aeromonad septicaemia in ornamental fish. This is the first isolation of A. dhakensis from a septicaemic ornamental fish since its original description from the same host.

  2. Smart Signs Show You the Way

    NARCIS (Netherlands)

    Lijding, M.E.M.; Meratnia, Nirvana; Benz, H.P.; Matysiak Szóstek, A.

    Smart Signs are a new type of electronic door and way signs based on small computers which can be seamlessly incorporated in the environment. Smart Signs provide personalized context-aware guidance and messaging designed to support wayfinding activities in large indoor spaces and their surroundings.

  3. Smart Signs: Showing the way in Smart Surroundings

    NARCIS (Netherlands)

    Lijding, M.E.M.; Benz, H.P.; Meratnia, Nirvana; Havinga, Paul J.M.

    This paper presents a context-aware guidance and messaging system for large buildings and surrounding venues. Smart Signs are a new type of electronic door- and way-sign based on wireless sensor networks. Smart Signs present in-situ personalized guidance and messages, are ubiquitous, and easy to

  4. Map showing landslide susceptibility in Prince Georges County, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Pomeroy, J.S.

    1989-01-01

    Prince Georges County was identified during a statewide investigation of landslide susceptibility (MF-2048) as the county with the most serious slope-stability problems. This map uses a ranking system ranging from 1 (nil to very low susceptibility) to 4 (moderate to severe susceptibility). Geologic factors and precipitation are major elements in the initiation of landslides in the county. The Potomac Group and the Marlboro Clay are the most slideprone units. This map should enable users to make a rapid, generalized evaluation of the potential for mass movement. Planners, engineers, soil scientists, geologist, university faculty, and elected officials should find it useful in the assessment of slope hazards for county-wide analyses.

  5. DC-SIGN (CD209) Promoter −336 A/G (rs4804803) Polymorphism Associated with Susceptibility of Kawasaki Disease

    Science.gov (United States)

    Yu, Hong-Ren; Chang, Wei-Pin; Wang, Lin; Lin, Ying-Jui; Liang, Chi-Di; Yang, Kuender D.; Kuo, Chiu-Ming; Huang, Yi-Chuan; Chang, Wei-Chiao; Kuo, Ho-Chang

    2012-01-01

    Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. High-dose intravenous immunoglobulin (IVIG) is the most effective therapy for KD to reduce the prevalence of coronary artery lesion (CAL) formation. Recently, the α2, 6 sialylated IgG was reported to interact with a lectin receptor, specific intracellular adhesion molecule-3 grabbing nonintegrin homolog-related 1 (SIGN-R1) in mice and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) in human, and to trigger an anti-inflammatory cascade. This study was conducted to investigate whether the polymorphism of DC-SIGN (CD209) promoter −336 A/G (rs4804803) is responsible for susceptibility and CAL formation in KD patients using Custom TaqMan SNP Genotyping Assays. A total of 521 subjects (278 KD patients and 243 controls) were investigated to identify an SNP of rs4804803, and they were studied and showed a significant association between the genotypes and allele frequency of rs4804803 in control subjects and KD patients (P = 0.004 under the dominant model). However, the promoter variant of DC-SIGN gene was not associated with the occurrence of IVIG resistance, CAL formation in KD. The G allele of DC-SIGN promoter −336 (rs4804803) is a risk allele in the development of KD. PMID:22629172

  6. DC-SIGN (CD209) promoter -336 A/G (rs4804803) polymorphism associated with susceptibility of Kawasaki disease.

    Science.gov (United States)

    Yu, Hong-Ren; Chang, Wei-Pin; Wang, Lin; Lin, Ying-Jui; Liang, Chi-Di; Yang, Kuender D; Kuo, Chiu-Ming; Huang, Yi-Chuan; Chang, Wei-Chiao; Kuo, Ho-Chang

    2012-01-01

    Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. High-dose intravenous immunoglobulin (IVIG) is the most effective therapy for KD to reduce the prevalence of coronary artery lesion (CAL) formation. Recently, the α2, 6 sialylated IgG was reported to interact with a lectin receptor, specific intracellular adhesion molecule-3 grabbing nonintegrin homolog-related 1 (SIGN-R1) in mice and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) in human, and to trigger an anti-inflammatory cascade. This study was conducted to investigate whether the polymorphism of DC-SIGN (CD209) promoter -336 A/G (rs4804803) is responsible for susceptibility and CAL formation in KD patients using Custom TaqMan SNP Genotyping Assays. A total of 521 subjects (278 KD patients and 243 controls) were investigated to identify an SNP of rs4804803, and they were studied and showed a significant association between the genotypes and allele frequency of rs4804803 in control subjects and KD patients (P = 0.004 under the dominant model). However, the promoter variant of DC-SIGN gene was not associated with the occurrence of IVIG resistance, CAL formation in KD. The G allele of DC-SIGN promoter -336 (rs4804803) is a risk allele in the development of KD.

  7. Overestimation of Susceptibility Vessel Sign: A Predictive Marker of Stroke Cause.

    Science.gov (United States)

    Zhang, Ruiting; Zhou, Ying; Liu, Chang; Zhang, Meixia; Yan, Shenqiang; Liebeskind, David S; Lou, Min

    2017-07-01

    The extent of blooming artifact may reflect the amount of paramagnetic material. We thus assessed the overestimation ratio of susceptibility vessel sign (SVS) on susceptibility-weighted imaging, defined as the extent of SVS width beyond the lumen and examined its value for predicting the stroke cause in acute ischemic stroke patients. We included consecutive acute ischemic stroke patients with proximal large artery occlusion who underwent both susceptibility-weighted imaging and time-of-flight magnetic resonance angiography within 8 hours poststroke onset. We calculated the length, width, and overestimation ratio of SVS on susceptibility-weighted imaging and then investigated their values for predicting the stroke cause, respectively. One-hundred eleven consecutive patients (72 female; mean age, 66.6±13.4 years) were enrolled, among whom 39 (35.1%) were diagnosed with cardiogenic embolism, 43 (38.7%) with large artery atherosclerosis, and 29 (26.1%) with undetermined cause. The presence, length, width, and overestimation ratio of SVS were all independently associated with the cause of cardiogenic embolism after adjusting for baseline National Institute of Health Stroke Scale and infarct volume. After excluded patients with undetermined cause, the sensitivity and specificity of overestimation ratio of SVS for cardiogenic embolism were 0.971 and 0.913; for the length of SVS, they were 0.629 and 0.739; for the width of SVS, they were 0.829 and 0.826, respectively. The overestimation ratio of SVS can predict cardiogenic embolism, with both high sensitivity and specificity, which can be helpful for the management of acute ischemic stroke patients in hyperacute stage. © 2017 American Heart Association, Inc.

  8. MRI Interscanner Agreement of the Association between the Susceptibility Vessel Sign and Histologic Composition of Thrombi.

    Science.gov (United States)

    Bourcier, Romain; Détraz, Lili; Serfaty, Jean Michel; Delasalle, Beatrice Guyomarch; Mirza, Mahmood; Derraz, Imad; Toulgoat, Frédérique; Naggara, Olivier; Toquet, Claire; Desal, Hubert

    2017-11-01

    The susceptibility vessel sign (SVS) on magnetic resonance imaging (MRI) is related to thrombus location, composition, and size in acute stroke. No previous study has determined its inter-MRI scanner variability. We aimed to compare the diagnostic accuracy in-vitro of four different MRI scanners for the characterization of histologic thrombus composition. Thirty-five manufactured thrombi analogs of different composition that were histologically categorized as fibrin-dominant, mixed, or red blood cell (RBC)-dominant were scanned on four different MRI units with T2* sequence. Nine radiologists, blinded to thrombus composition and MRI scanner model, classified twice, in a 2-week interval, the SVS of each thrombus as absent, questionable, or present. We calculated the weighted kappa with 95% confidence interval (CI), sensitivity, specificity and accuracy of the SVS on each MRI scanner to detect RBC-dominant thrombi. The SVS was present in 42%, absent in 33%, and questionable in 25% of thrombi. The interscanner agreement was moderate to good, ranging from .45 (CI: .37-.52) to .67 (CI: .61-.74). The correlation between the SVS and the thrombus composition was moderate (κ: .50 [CI: .44-.55]) to good κ: .76 ([CI: .72-.80]). Sensitivity, specificity, and accuracy to identify RBC-dominant clots were significantly different between MRI scanners (P composition varies significantly among MRI scanners. Normalization of T2*sequences between scanners may be needed to better predict thrombus composition in multicenter studies. Copyright © 2017 by the American Society of Neuroimaging.

  9. Coronectomy as the treatment of choice in wisdom teeth showing radiographic signs of close proximity to inferior dental nerve.

    Science.gov (United States)

    Leung, Yiu Yan; Cheung, Lim Kwong

    2010-03-01

    The aim of the study is to compare the prevalence of post-operative inferior dental nerve (IDN) deficit after coronectomy with total removal of wisdom teeth showing specific radiographic signs of close proximity to IDN. A randomized clinical trial comparing total removal and coronectomy of wisdom tooth was conducted. Analyses of the correlations of IDN deficit and various radiographic signs of wisdom tooth roots showing close proximity to IDN were performed. Two radiographic signs were found to be positive predictors ofintra-operative IDN exposure. Specific radiographic signs or the presence of two or more radiographic signs are positive predictors of post-operative IDN deficit. The study concluded that darkening of the wisdom tooth root and presence of two or more specific signs in radiographs significantly increased the risk of IDN deficit in lower wisdom tooth surgery. Coronectomy can significantly reduce the prevalence of an IDN deficit in patients with lower wisdom teeth showing radiographic signs of close proximity to IDN. It also carries less surgical morbidities when compared with total removal of lower wisdom tooth.

  10. Showing no spot sign is a strong predictor of independent living after intracerebral haemorrhage

    DEFF Research Database (Denmark)

    Havsteen, Inger; Ovesen, Christian; Christensen, Anders F

    2014-01-01

    . The standard work-up in our centre included CTA for spot sign status, unless a contraindication was present. Modified Rankin Scale (mRS) scores were assessed at 3 months in the outpatient clinic or by telephone interviews. Long-term mortality was assessed by electronic chart follow-up for up to 1,500 days...

  11. Cunninghamella bertholletiae pneumonia showing a reversed halo sign on chest computed tomography scan following cord blood transplantation.

    Science.gov (United States)

    Kimura, Muneyoshi; Araoka, Hideki; Uchida, Naoyuki; Ohno, Hideaki; Miyazaki, Yoshitsugu; Fujii, Takeshi; Nishida, Aya; Izutsu, Koji; Wake, Atsushi; Taniguchi, Shuichi; Yoneyama, Akiko

    2012-05-01

    This is the first reported case of a patient who developed fungal pneumonia caused by Cunninghamella bertholletiae (= C. elegans) following cord blood transplantation and who showed a reversed halo sign on a chest computed tomography scan (CT). In addition, the pathological findings related to the reversed halo sign are described in detail for the first time. The patient died due to respiratory failure and at autopsy, a consolidation corresponding to the reversed halo sign noted on CT was found histologically to be composed of a central infarct with some retained air spaces surrounded by a peripheral ring-like hemorrhagic band. Pulmonary vasculatures were occluded by thrombi containing numerous Zygomycetes hyphae within the central infarct and less frequently along the surrounding hemorrhagic band. A reversed halo sign may be an early marker to initiate preemptive therapy against Zygomycetes including C. bertholletiae.

  12. Telling true from false: cannabis users show increased susceptibility to false memories.

    Science.gov (United States)

    Riba, J; Valle, M; Sampedro, F; Rodríguez-Pujadas, A; Martínez-Horta, S; Kulisevsky, J; Rodríguez-Fornells, A

    2015-06-01

    Previous studies on the neurocognitive impact of cannabis use have found working and declarative memory deficits that tend to normalize with abstinence. An unexplored aspect of cognitive function in chronic cannabis users is the ability to distinguish between veridical and illusory memories, a crucial aspect of reality monitoring that relies on adequate memory function and cognitive control. Using functional magnetic resonance imaging, we show that abstinent cannabis users have an increased susceptibility to false memories, failing to identify lure stimuli as events that never occurred. In addition to impaired performance, cannabis users display reduced activation in areas associated with memory processing within the lateral and medial temporal lobe (MTL), and in parietal and frontal brain regions involved in attention and performance monitoring. Furthermore, cannabis consumption was inversely correlated with MTL activity, suggesting that the drug is especially detrimental to the episodic aspects of memory. These findings indicate that cannabis users have an increased susceptibility to memory distortions even when abstinent and drug-free, suggesting a long-lasting compromise of memory and cognitive control mechanisms involved in reality monitoring.

  13. Very Preterm Infants Failing CPAP Show Signs of Fatigue Immediately after Birth.

    Directory of Open Access Journals (Sweden)

    Melissa L Siew

    Full Text Available To investigate the differences in breathing pattern and effort in infants at birth who failed or succeeded on continuous positive airway pressure (CPAP during the first 48 hours after birth.Respiratory function recordings of 32 preterm infants were reviewed of which 15 infants with a gestational age of 28.6 (0.7 weeks failed CPAP and 17 infants with a GA of 30.1 (0.4 weeks did not fail CPAP. Frequency, duration and tidal volumes (VT of expiratory holds (EHs, peak inspiratory flows, CPAP-level and FiO2-levels were analysed.EH incidence increased 9 ml/kg with higher peak inspiratory flows than CPAP-fail infants (71.8 ± 15.8 vs. 15.5 ± 5.2 ml/kg.s, p <0.05. CPAP-fail infants required higher FiO2 (0.31 ± 0.03 vs. 0.21 ± 0.01, higher CPAP pressures (6.62 ± 0.3 vs. 5.67 ± 0.26 cmH2O and more positive pressure-delivered breaths (45 ± 12 vs. 19 ± 9% (p <0.05.At 9-12 minutes after birth, CPAP-fail infants more commonly used lower VTs and required higher peak inspiratory flow rates while receiving greater respiratory support. VT was less variable and larger VT was infrequently used reflecting early signs of fatigue.

  14. Microscopy and Serological Assessment for Heartworm Infection in Cats in Makati, Philippines Showing Clinical Signs of Dirofilariosis

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    A Baticados

    2013-03-01

    Full Text Available Background: The sole published data on feline heartworm infection in the Philippines was reported four decades ago. The study therefore endeavoured to assess and provide an update on the current status of heartworm infection in domesticated feline species using serologic and parasitological examina­tion methods.Methods: A total of 46 males and 54 females cats showing clinical signs of dirofilariosis from Makati City, Philippines were subjected to two antigen-based test kits and a microfilaria concentration method.Results: The most commonly observed clinical sign was coughing while exercise intolerance was seldom seen. Age groups ranging from 1 to 4 years old exhibited majority of the clinical signs whereas the 8.1 to 12 years category had the least. The results from the different detection methods employed revealed that none of the animals were positive for circulating microfilaria and no detect­able levels of heartworm antigens were obtained.Conclusion: The presence of associated clinical signs is not an outright indicator of feline dirofilariosis and may be indicative of the rarity of heartworm infection in cats in Makati, Philippines.

  15. Alcohol-Preferring Rats Show Goal Oriented Behaviour to Food Incentives but Are Neither Sign-Trackers Nor Impulsive.

    Science.gov (United States)

    Peña-Oliver, Yolanda; Giuliano, Chiara; Economidou, Daina; Goodlett, Charles R; Robbins, Trevor W; Dalley, Jeffrey W; Everitt, Barry J

    2015-01-01

    Drug addiction is often associated with impulsivity and altered behavioural responses to both primary and conditioned rewards. Here we investigated whether selectively bred alcohol-preferring (P) and alcohol-nonpreferring (NP) rats show differential levels of impulsivity and conditioned behavioural responses to food incentives. P and NP rats were assessed for impulsivity in the 5-choice serial reaction time task (5-CSRTT), a widely used translational task in humans and other animals, as well as Pavlovian conditioned approach to measure sign- and goal-tracking behaviour. Drug-naïve P and NP rats showed similar levels of impulsivity on the 5-CSRTT, assessed by the number of premature, anticipatory responses, even when the waiting interval to respond was increased. However, unlike NP rats, P rats were faster to enter the food magazine and spent more time in this area. In addition, P rats showed higher levels of goal-tracking responses than NP rats, as measured by the number of magazine nose-pokes during the presentation of a food conditioned stimulus. By contrast, NP showed higher levels of sign-tracking behaviour than P rats. Following a 4-week exposure to intermittent alcohol we confirmed that P rats had a marked preference for, and consumed more alcohol than, NP rats, but were not more impulsive when re-tested in the 5-CSRTT. These findings indicate that high alcohol preferring and drinking P rats are neither intrinsically impulsive nor do they exhibit impulsivity after exposure to alcohol. However, P rats do show increased goal-directed behaviour to food incentives and this may be associated with their strong preference for alcohol.

  16. Alcohol-Preferring Rats Show Goal Oriented Behaviour to Food Incentives but Are Neither Sign-Trackers Nor Impulsive.

    Directory of Open Access Journals (Sweden)

    Yolanda Peña-Oliver

    Full Text Available Drug addiction is often associated with impulsivity and altered behavioural responses to both primary and conditioned rewards. Here we investigated whether selectively bred alcohol-preferring (P and alcohol-nonpreferring (NP rats show differential levels of impulsivity and conditioned behavioural responses to food incentives. P and NP rats were assessed for impulsivity in the 5-choice serial reaction time task (5-CSRTT, a widely used translational task in humans and other animals, as well as Pavlovian conditioned approach to measure sign- and goal-tracking behaviour. Drug-naïve P and NP rats showed similar levels of impulsivity on the 5-CSRTT, assessed by the number of premature, anticipatory responses, even when the waiting interval to respond was increased. However, unlike NP rats, P rats were faster to enter the food magazine and spent more time in this area. In addition, P rats showed higher levels of goal-tracking responses than NP rats, as measured by the number of magazine nose-pokes during the presentation of a food conditioned stimulus. By contrast, NP showed higher levels of sign-tracking behaviour than P rats. Following a 4-week exposure to intermittent alcohol we confirmed that P rats had a marked preference for, and consumed more alcohol than, NP rats, but were not more impulsive when re-tested in the 5-CSRTT. These findings indicate that high alcohol preferring and drinking P rats are neither intrinsically impulsive nor do they exhibit impulsivity after exposure to alcohol. However, P rats do show increased goal-directed behaviour to food incentives and this may be associated with their strong preference for alcohol.

  17. Hearts of dystonia musculorum mice display normal morphological and histological features but show signs of cardiac stress.

    Directory of Open Access Journals (Sweden)

    Justin G Boyer

    2010-03-01

    Full Text Available Dystonin is a giant cytoskeletal protein belonging to the plakin protein family and is believed to crosslink the major filament systems in contractile cells. Previous work has demonstrated skeletal muscle defects in dystonin-deficient dystonia musculorum (dt mice. In this study, we show that the dystonin muscle isoform is localized at the Z-disc, the H zone, the sarcolemma and intercalated discs in cardiac tissue. Based on this localization pattern, we tested whether dystonin-deficiency leads to structural defects in cardiac muscle. Desmin intermediate filament, microfilament, and microtubule subcellular organization appeared normal in dt hearts. Nevertheless, increased transcript levels of atrial natriuretic factor (ANF, 66% beta-myosin heavy chain (beta-MHC, 95% and decreased levels of sarcoplasmic reticulum calcium pump isoform 2A (SERCA2a, 26%, all signs of cardiac muscle stress, were noted in dt hearts. Hearts from two-week old dt mice were assessed for the presence of morphological and histological alterations. Heart to body weight ratios as well as left ventricular wall thickness and left chamber volume measurements were similar between dt and wild-type control mice. Hearts from dt mice also displayed no signs of fibrosis or calcification. Taken together, our data provide new insights into the intricate structure of the sarcomere by situating dystonin in cardiac muscle fibers and suggest that dystonin does not significantly influence the structural organization of cardiac muscle fibers during early postnatal development.

  18. Method of Evaluating Hydrogen Embrittlement Susceptibility of Tempered Martensitic Steel Showing Intergranular Fracture

    Science.gov (United States)

    Matsumoto, Yu; Takai, Kenichi

    2018-02-01

    A stress application method in delayed fracture susceptibility tests was investigated using 1450 MPa class tempered martensitic steel. Its fracture mode under hydrogen charging was mainly intergranular because of its relatively small Si content of 0.21 mass pct. The conditions for consistency in fracture strength between tensile tests and constant load tests (CLTs) were clarified: first, to conduct hydrogen precharging before stress application; and second, to choose a sufficiently low crosshead speed in tensile tests. When hydrogen precharging was not conducted before CLTs, the fracture strength was higher than the values in CLTs with hydrogen charging and in tensile tests. If the crosshead speed was too high, the fracture strength obtained was higher than the values in CLTs. The dependence of the fracture strength on crosshead speed was seen for both notched and smooth bar specimens. These results suggested that plastic deformation, i.e., dislocation motion, was related to intergranular fracture with a tear pattern as well as to quasi-cleavage fracture. In addition, cathodic electrolysis in an alkaline solution containing NaOH should be used as the hydrogen charging method to avoid the effects of corrosion.

  19. Method of Evaluating Hydrogen Embrittlement Susceptibility of Tempered Martensitic Steel Showing Intergranular Fracture

    Science.gov (United States)

    Matsumoto, Yu; Takai, Kenichi

    2017-12-01

    A stress application method in delayed fracture susceptibility tests was investigated using 1450 MPa class tempered martensitic steel. Its fracture mode under hydrogen charging was mainly intergranular because of its relatively small Si content of 0.21 mass pct. The conditions for consistency in fracture strength between tensile tests and constant load tests (CLTs) were clarified: first, to conduct hydrogen precharging before stress application; and second, to choose a sufficiently low crosshead speed in tensile tests. When hydrogen precharging was not conducted before CLTs, the fracture strength was higher than the values in CLTs with hydrogen charging and in tensile tests. If the crosshead speed was too high, the fracture strength obtained was higher than the values in CLTs. The dependence of the fracture strength on crosshead speed was seen for both notched and smooth bar specimens. These results suggested that plastic deformation, i.e., dislocation motion, was related to intergranular fracture with a tear pattern as well as to quasi-cleavage fracture. In addition, cathodic electrolysis in an alkaline solution containing NaOH should be used as the hydrogen charging method to avoid the effects of corrosion.

  20. Method of Evaluating Delayed Fracture Susceptibility of Tempered Martensitic Steel Showing Quasi-Cleavage Fracture

    Science.gov (United States)

    Matsumoto, Yu; Takai, Kenichi

    2017-02-01

    The difference in the hydrogen charging methods, immersion in a NH4SCN aqueous solution, and cathodic electrolysis in a NaOH aqueous solution, did not affect the hydrogen state present in the steel, but it did affect the surface state of the specimens through corrosion, causing fracture strength to fluctuate in tensile testes. As for stress application method, the fracture strength at lower crosshead speeds in tensile tests was consistent with that found for hydrogen precharging prior to stress application in CLTs as long as hydrogen charging was conducted by cathodic electrolysis. However, the fracture strength obtained with concurrent hydrogen charging without precharging prior to stress application in CLTs was higher than that with hydrogen precharging prior to stress application in CLTs regardless of the same hydrogen content. In other words, delayed fracture susceptibility was affected by the order of hydrogen charging and stress application for quasi-cleavage fracture associated with local plastic deformation, i.e., dislocation motion. Therefore, by taking into account the cathodic electrolysis in the NaOH solution, the low crosshead speed and the order of hydrogen charging and stress application, the fracture strength in CLTs, and tensile tests coincided with respect to quasi-cleavage fracture even though the stress application methods were different.

  1. Association of DC-SIGN and DC-SIGNR Repeat Regions with Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeastern Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Naderi

    2016-05-01

    Full Text Available There are conflicting results concerning DC-SIGN and DC-SIGNR VNTR polymorphisms. The present study aimed to evaluate the possible association between DC-SIGN as well as DC-SIGNR VNTR polymorphisms and pulmonary tuberculosis (PTB in a sample of Iranian population. This case-control study was done on 171 PTB and 161 healthy subjects. The variants were detected by polymerase chain reaction (PCR. DC-SIGNR VNTR genotypes in cases were 12.7% for 5/5, 2.4% for 6/5, 32.7% for 7/7, 38.2% for 7/5, 5.5% for 7/6, 1.2% for /5, 0.6% for 9/6, 6.7% for 9/7 in PTB patients and 19.7% for 5/5, 2.0% for 6/5, 31.6% for 7/7, 37.5% for 7/5, 5.7% for 7/6, 0.0% for 9/5, 0.7% for 9/6, 2.6% for 9/7 in controls. The findings showed no significant association between DC-SIGNR VNTR polymorphism and PTB. All subjects in cases and controls were 7/7 genotype regarding DC-SIGN VNTR polymorphism. Our data propose that DC-SIGNR VNTR, as well as DC-SIGN VNTR, were not associated with the risk of PTB in a sample of Iranian population.

  2. Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.

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    Sonia Perez-Sieira

    Full Text Available Adipose tissue is essential in the regulation of body weight. The key process in fat catabolism and the provision of energy substrate during times of nutrient deprivation or enhanced energy demand is the hydrolysis of triglycerides and the release of fatty acids and glycerol. Nur77 is a member of the NR4A subfamily of nuclear receptors that plays an important metabolic role, modulating hepatic glucose metabolism and lipolysis in muscle. However, its endogenous role on white adipose tissue, as well as the gender dependency of these mechanisms, remains largely unknown. Male and female wild type and Nur77 deficient mice were fed with a high fat diet (45% calories from fat for 4 months. Mice were analyzed in vivo with the indirect calorimetry system, and tissues were analyzed by real-time PCR and Western blot analysis. Female, but not male Nur77 deficient mice, gained more weight and fat mass when compared to wild type mice fed with high fat diet, which can be explained by decreased energy expenditure. The lack of Nur77 also led to a decreased pHSL/HSL ratio in white adipose tissue and increased expression of CIDEA in brown adipose tissue of female Nur77 deficient mice. Overall, these findings suggest that Nur77 is an important physiological modulator of lipid metabolism in adipose tissue and that there are gender differences in the sensitivity to deletion of the Nur77 signaling. The decreased energy expenditure and the actions of Nur77 on liver, muscle, brown and white adipose tissue contribute to the increased susceptibility to diet-induced obesity in females lacking Nur77.

  3. Telling true from false: cannabis users show increased susceptibility to false memories

    OpenAIRE

    Riba, J; Valle, M.; Sampedro, F; Rodr?guez-Pujadas, A; Mart?nez-Horta, S; Kulisevsky, J; Rodr?guez-Fornells, A

    2015-01-01

    Previous studies on the neurocognitive impact of cannabis use have found working and declarative memory deficits that tend to normalize with abstinence. An unexplored aspect of cognitive function in chronic cannabis users is the ability to distinguish between veridical and illusory memories, a crucial aspect of reality monitoring that relies on adequate memory function and cognitive control. Using functional magnetic resonance imaging, we show that abstinent cannabis users have an increased s...

  4. Vital Signs

    Science.gov (United States)

    Your vital signs show how well your body is functioning. They are usually measured at doctor's offices, often as part of ... slow or fast breathing can also be a sign of a serious breathing problem. Temperature, which measures ...

  5. Proximal Bright Vessel Sign on Arterial Spin Labeling Magnetic Resonance Imaging in Acute Cardioembolic Cerebral Infarction.

    Science.gov (United States)

    Kato, Ayumi; Shinohara, Yuki; Kuya, Keita; Sakamoto, Makoto; Kowa, Hisanori; Ogawa, Toshihide

    2017-07-01

    The congestion of spin-labeled blood at large-vessel occlusion can present as hyperintense signals on perfusion magnetic resonance imaging with 3-dimensional pseudo-continuous arterial spin labeling (proximal bright vessel sign). The purpose of this study was to clarify the difference between proximal bright vessel sign and susceptibility vessel sign in acute cardioembolic cerebral infarction. Forty-two patients with cardioembolic cerebral infarction in the anterior circulation territory underwent magnetic resonance imaging including diffusion-weighted imaging, 3-dimensional pseudo-continuous arterial spin labeling perfusion magnetic resonance imaging, T2*-weighted imaging, and 3-dimensional time-of-flight magnetic resonance angiography using a 3-T magnetic resonance scanner. Visual assessments of proximal bright vessel sign and the susceptibility vessel sign were performed by consensus of 2 experienced neuroradiologists. The relationship between these signs and the occlusion site of magnetic resonance angiography was also investigated. Among 42 patients with cardioembolic cerebral infarction, 24 patients showed proximal bright vessel sign (57.1%) and 25 showed susceptibility vessel sign (59.5%). There were 19 cases of proximal bright vessel sign and susceptibility vessel sign-clear, 12 cases of proximal bright vessel sign and susceptibility vessel sign-unclear, and 11 mismatched cases. Four out of 6 patients with proximal bright vessel sign-unclear and susceptibility vessel sign-clear showed distal middle cerebral artery occlusion, and 2 out of 5 patients with proximal bright vessel sign-clear and susceptibility vessel sign-unclear showed no occlusion on magnetic resonance angiography. Proximal bright vessel sign is almost compatible with susceptibility vessel sign in patients with cardioembolic cerebral infarction. Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  6. Magnetic resonance imaging showed no signs of overuse or permanent injury to the lumbar sacral spine during a Special Forces training course.

    Science.gov (United States)

    Aharony, Shachar; Milgrom, Charles; Wolf, Tamir; Barzilay, Yair; Applbaum, Yaakov H; Schindel, Yair; Finestone, Aharon; Liram, Nimrod

    2008-01-01

    Special Forces training is even more demanding than that of elite athletes. The training includes grueling physical activity and periods of sleep deprivation. The soldiers routinely carry heavy loads up to 40% of their body weight on their backs while running and marching for distances up to 90 km. Our purpose was to find out if Special Forces recruits are able to complete the preparatory Navy Seals training program without sustaining magnetic resonance imaging (MRI) signs of overuse or irreversible injury to their backs. Prospective cohort study. We performed MRI scans before and after 14 weeks of Navy Seals preparatory training course. Ten soldiers underwent MRI of their lumbar sacral spines and right knees before and after the completion of Navy Seals preparatory training. Physiologic measures. Lumbar sacral spine and knee MRI tests were performed before and after the training to identify changes in the spinal discs, facet joints, pars interarticularis, vertebral bodies, knee articular cartilage, ligaments, knee menisci, and the presence or absence of soft tissue and/or bone edema. We investigated the difference in spine and knee pathology before and after a 14-week Navy Seals preparatory training course by using MRI criteria. The recruits participating in the study were monitored for acute and overuse injuries every 3 to 4 weeks. Before the training, seven out of ten spine MRI scans were normal. Two showed small L5-S1 disc bulges, one of them with concomitant Scheuermann's disease. Another soldier's MRI showed L1-L4 mild Scheuermann's disease. Follow-up MRI showed no spinal changes. Before the training, one knee had a small lateral femoral condyle cartilage lesion. Nine of ten knees had prepatellar swelling, five had increased joint fluid, and two bone edema. Follow-up magnetic resonance imaging showed improvement in the prepatellar swelling in eight soldiers, no change in one soldier, and increased knee effusion and a new medial femoral condyle bone edema in

  7. Is the Susceptibility Vessel Sign on 3-Tesla Magnetic Resonance T2*-Weighted Imaging a Useful Tool to Predict Recanalization in Intravenous Tissue Plasminogen Activator?

    Science.gov (United States)

    Yamamoto, N; Satomi, J; Harada, M; Izumi, Y; Nagahiro, S; Kaji, R

    2016-09-01

    The aim of this study was to investigate the independent factors associated with the absence of recanalization approximately 24 h after intravenous administration of tissue-type plasminogen activator (IV TPA). The previous studies have been conducted using 1.5-Tesla (T) magnetic resonance imaging (MRI). We studied whether the characteristics of 3-T MRI findings were useful to predict outcome and recanalization after IV tPA. Patients with internal carotid artery (ICA) or middle cerebral artery (MCA) (horizontal portion, M1; Sylvian portion, M2) occlusion and treated by IV tPA were enrolled. We studied whether the presence of susceptibility vessel sign (SVS) at M1 and low clot burden score on T2*-weighted imaging (T2*-CBS) on 3-T MRI were associated with the absence of recanalization. A total of 49 patients were enrolled (27 men; mean age, 73.9 years). MR angiography obtained approximately 24 h after IV tPA revealed recanalization in 21 (42.9 %) patients. Independent factors associated with the absence of recanalization included ICA or proximal M1 occlusion (odds ratio, 69.6; 95 % confidence interval, 5.05-958.8, p = 0.002). In this study, an independent factor associated with the absence of recanalization may be proximal occlusion of the cerebral arteries rather than SVS in the MCA or low T2*-CBS on 3-T MRI.

  8. Full genome sequence of a novel circo-like virus detected in an adult European eel Anguilla anguilla showing signs of cauliflower disease.

    Science.gov (United States)

    Doszpoly, Andor; Tarján, Zoltán L; Glávits, Róbert; Müller, Tamás; Benkő, Mária

    2014-05-13

    An adult European eel Anguilla anguilla, showing typical signs of the so-called cauliflower disease, was subjected to pathological and molecular virological examinations. Samples taken from internal organs and the polypoid proliferative tissue from the mouth were examined by PCR for the detection of several viruses. Positive results were obtained with a nested PCR targeting the rep gene of circoviruses. Analysis of the partial rep sequence indicated the presence of a putative novel circovirus, but attempts to isolate it remained unsuccessful. The missing part of the genome was acquired by an inverse nested PCR with 2 specific primer pairs, designed from the newly determined rep sequence, followed by genome walking. The circular full genome was found to consist of 1378 nt (GenBank accession no. KC469701). Two oppositely oriented open reading frames (ORFs) were present, of which one was unambiguously identified as a circoviral rep gene. However, the predicted product of the other ORF, though it is a clear positional counterpart of the cap genes, showed no obvious homology to any known circoviral capsid proteins. A stem-loop-like element in the intergenic region between the 5' ends of the ORFs was also found. Phylogenetic calculations indicated that the novel virus belongs to the genus Circovirus in the family Circoviridae. The relative amount of the viral DNA in the organ samples was estimated by quantitative real-time PCR. The results suggested that the examined fish was caught in an active viremic state, although the role of this circovirus in the etiology of the cauliflower diseases could not be ascertained.

  9. Using 'swallow-tail' sign and putaminal hypointensity as biomarkers to distinguish multiple system atrophy from idiopathic Parkinson's disease: A susceptibility-weighted imaging study

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Na; Yang, HuaGuang; Li, ChengBo; Fan, GuoGuang [The First Affiliated Hospital of China Medical University, Department of Radiology, Shenyang, Liaoning (China); Luo, XiaoGuang [The First Affiliated Hospital of China Medical University, Department of Neurology, Shenyang, Liaoning (China)

    2017-08-15

    To investigate the value of 'swallow-tail' sign and putaminal hypointensity on 3 T susceptibility-weighted imaging (SWI) for distinguishing multiple system atrophy (MSA) from idiopathic Parkinson's disease (IPD). Three groups - 39 MSA patients, 18 IPD patients,and 31 healthy controls (HCs) - were administered a 3 T SWI sequence to evaluate 'swallow-tail' sign and putaminal hypointensity using visual scales from 0 to 2 and 0 to 3 scores, respectively. The diagnostic accuracy of the two signs separately and combined was calculated using a receiver operating characteristic curve, with clinical diagnosis as the gold standard. The scores of 'swallow-tail' sign were lower in IPD than in MSA or in HCs, as well as for putaminal hypointensity in IPD or HCs than in MSA (p < 0.05). The sensitivity and specificity of 'swallow-tail' sign and putaminal hypointensity were 87.9% and 83.3%, and 35.9% and 100%, respectively, in the respective patient groups. The area under the curve of combined signs was increased from 0.85 ('swallow tail') or 0.68 (putaminal hypointensity) to 0.93. The combination of 'swallow-tail' sign and putaminal hypointensity can increase the accuracy of discriminating between MSA and IPD. (orig.)

  10. Chimpanzees show a developmental increase in susceptibility to contagious yawning: a test of the effect of ontogeny and emotional closeness on yawn contagion.

    Directory of Open Access Journals (Sweden)

    Elainie Alenkær Madsen

    Full Text Available Contagious yawning has been reported for humans, dogs and several non-human primate species, and associated with empathy in humans and other primates. Still, the function, development and underlying mechanisms of contagious yawning remain unclear. Humans and dogs show a developmental increase in susceptibility to yawn contagion, with children showing an increase around the age of four, when also empathy-related behaviours and accurate identification of others' emotions begin to clearly evince. Explicit tests of yawn contagion in non-human apes have only involved adult individuals and examined the existence of conspecific yawn contagion. Here we report the first study of heterospecific contagious yawning in primates, and the ontogeny of susceptibility thereto in chimpanzees, Pan troglodytes verus. We examined whether emotional closeness, defined as attachment history with the yawning model, affected the strength of contagion, and compared the contagiousness of yawning to nose-wiping. Thirty-three orphaned chimpanzees observed an unfamiliar and familiar human (their surrogate human mother yawn, gape and nose-wipe. Yawning, but not nose-wiping, was contagious for juvenile chimpanzees, while infants were immune to contagion. Like humans and dogs, chimpanzees are subject to a developmental trend in susceptibility to contagious yawning, and respond to heterospecific yawn stimuli. Emotional closeness with the model did not affect contagion. The familiarity-biased social modulatory effect on yawn contagion previously found among some adult primates, seem to only emerge later in development, or be limited to interactions with conspecifics. The influence of the 'chameleon effect', targeted vs. generalised empathy, perspective-taking and visual attention on contagious yawning is discussed.

  11. Chimpanzees show a developmental increase in susceptibility to contagious yawning: a test of the effect of ontogeny and emotional closeness on yawn contagion.

    Science.gov (United States)

    Madsen, Elainie Alenkær; Persson, Tomas; Sayehli, Susan; Lenninger, Sara; Sonesson, Göran

    2013-01-01

    Contagious yawning has been reported for humans, dogs and several non-human primate species, and associated with empathy in humans and other primates. Still, the function, development and underlying mechanisms of contagious yawning remain unclear. Humans and dogs show a developmental increase in susceptibility to yawn contagion, with children showing an increase around the age of four, when also empathy-related behaviours and accurate identification of others' emotions begin to clearly evince. Explicit tests of yawn contagion in non-human apes have only involved adult individuals and examined the existence of conspecific yawn contagion. Here we report the first study of heterospecific contagious yawning in primates, and the ontogeny of susceptibility thereto in chimpanzees, Pan troglodytes verus. We examined whether emotional closeness, defined as attachment history with the yawning model, affected the strength of contagion, and compared the contagiousness of yawning to nose-wiping. Thirty-three orphaned chimpanzees observed an unfamiliar and familiar human (their surrogate human mother) yawn, gape and nose-wipe. Yawning, but not nose-wiping, was contagious for juvenile chimpanzees, while infants were immune to contagion. Like humans and dogs, chimpanzees are subject to a developmental trend in susceptibility to contagious yawning, and respond to heterospecific yawn stimuli. Emotional closeness with the model did not affect contagion. The familiarity-biased social modulatory effect on yawn contagion previously found among some adult primates, seem to only emerge later in development, or be limited to interactions with conspecifics. The influence of the 'chameleon effect', targeted vs. generalised empathy, perspective-taking and visual attention on contagious yawning is discussed.

  12. Transgenic apple plants overexpressing the chalcone 3-hydroxylase gene of Cosmos sulphureus show increased levels of 3-hydroxyphloridzin and reduced susceptibility to apple scab and fire blight.

    Science.gov (United States)

    Hutabarat, Olly Sanny; Flachowsky, Henryk; Regos, Ionela; Miosic, Silvija; Kaufmann, Christine; Faramarzi, Shadab; Alam, Mohammed Zobayer; Gosch, Christian; Peil, Andreas; Richter, Klaus; Hanke, Magda-Viola; Treutter, Dieter; Stich, Karl; Halbwirth, Heidi

    2016-05-01

    Overexpression of chalcone-3-hydroxylase provokes increased accumulation of 3-hydroxyphloridzin in Malus . Decreased flavonoid concentrations but unchanged flavonoid class composition were observed. The increased 3-hydroxyphlorizin contents correlate well with reduced susceptibility to fire blight and scab. The involvement of dihydrochalcones in the apple defence mechanism against pathogens is discussed but unknown biosynthetic steps in their formation hamper studies on their physiological relevance. The formation of 3-hydroxyphloretin is one of the gaps in the pathway. Polyphenol oxidases and cytochrome P450 dependent enzymes could be involved. Hydroxylation of phloretin in position 3 has high similarity to the B-ring hydroxylation of flavonoids catalysed by the well-known flavonoid 3'-hydroxylase (F3'H). Using recombinant F3'H and chalcone 3-hydroxylase (CH3H) from Cosmos sulphureus we show that F3'H and CH3H accept phloretin to some extent but higher conversion rates are obtained with CH3H. To test whether CH3H catalyzes the hydroxylation of dihydrochalcones in planta and if this could be of physiological relevance, we created transgenic apple trees harbouring CH3H from C. sulphureus. The three transgenic lines obtained showed lower polyphenol concentrations but no shift between the main polyphenol classes dihydrochalcones, flavonols, hydroxycinnamic acids and flavan 3-ols. Increase of 3-hydroxyphloridzin within the dihydrochalcones and of epicatechin/catechin within soluble flavan 3-ols were observed. Decreased activity of dihydroflavonol 4-reductase and chalcone synthase/chalcone isomerase could partially explain the lower polyphenol concentrations. In comparison to the parent line, the transgenic CH3H-lines showed a lower disease susceptibility to fire blight and apple scab that correlated with the increased 3-hydroxyphlorizin contents.

  13. Low signal intensity in motor cortex on susceptibility-weighted MR imaging is correlated with clinical signs of amyotrophic lateral sclerosis: a pilot study.

    Science.gov (United States)

    Endo, Hironobu; Sekiguchi, Kenji; Shimada, Hitoshi; Ueda, Takehiro; Kowa, Hisatomo; Kanda, Fumio; Toda, Tatsushi

    2018-03-01

    There is no reliable objective indicator for upper motor neuron dysfunction in amyotrophic lateral sclerosis (ALS). To determine the clinical significance and potential utility of magnetic resonance (MR) signals, we investigated the relationship between clinical symptoms and susceptibility changes in the motor cortex measured using susceptibility-weighted MR imaging taken by readily available 3-T MRI in clinical practice. Twenty-four ALS patients and 14 control subjects underwent 3-T MR T1-weighted imaging and susceptibility-weighted MR imaging with the principles of echo-shifting with a train of observations (PRESTO) sequence. We analysed relationships between relative susceptibility changes in the motor cortex assessed using voxel-based analysis (VBA) and clinical scores, including upper motor neuron score, ALS functional rating scale revised score, and Medical Research Council sum score on physical examination. Patients with ALS exhibited significantly lower signal intensity in the precentral gyrus on susceptibility-weighted MR imaging compared with controls. Clinical scores were significantly correlated with susceptibility changes. Importantly, the extent of the susceptibility changes in the bilateral precentral gyri was significantly correlated with upper motor neuron scores. The results of our pilot study using VBA indicated that low signal intensity in motor cortex on susceptibility-weighted MR imaging may correspond to clinical symptoms, particularly upper motor neuron dysfunction. Susceptibility-weighted MR imaging may be a useful diagnostic tool as an objective indicator of upper motor neuron dysfunction.

  14. SIGNS The sandwich sign

    African Journals Online (AJOL)

    214. 5. Kunimasa K, Jo T, Takaiwa T, Ishida T. Thoracic sandwich sign. Intern Med 2011;50:2865. 6. Caceres J, Mata JM, Castaner E, Villanueva A. CT recognition of traumatic herniation of stomach: the sandwich sign. J Thorac Imaging 1995 ...

  15. Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene-gene interaction

    DEFF Research Database (Denmark)

    Sparsø, T; Grarup, N; Andreasen, C

    2009-01-01

    the area under a ROC curve to estimate the discrimination rate between glucose-tolerant individuals and type 2 diabetes patients based on the 19 variants. We found an area under the ROC curve of 0.60. Two-way gene-gene interaction showed few nominal interaction effects. CONCLUSIONS/INTERPRETATION: Combined...... analysis of the 19 validated variants enables detection of subgroups at substantially increased risk of type 2 diabetes; however, the discrimination between glucose-tolerant and type 2 diabetes individuals is still too inaccurate to achieve clinical value.......AIMS/HYPOTHESIS: The list of validated type 2 diabetes susceptibility variants has recently been expanded from three to 19. The variants identified are common and have low penetrance in the general population. The aim of the study is to investigate the combined effect of the 19 variants by applying...

  16. Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

    Science.gov (United States)

    Adoue, Véronique; Michailidou, Kyriaki; Canisius, Sander; Lemaçon, Audrey; Droit, Arnaud; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Baynes, Caroline; Blomqvist, Carl; Bogdanova, Natalia V.; Bojesen, Stig E.; Bolla, Manjeet K.; Bonanni, Bernardo; Borresen-Dale, Anne-Lise; Brand, Judith S.; Brauch, Hiltrud; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Chang-Claude, Jenny; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Darabi, Hatef; Dennis, Joe; Devilee, Peter; Dörk, Thilo; Dos-Santos-Silva, Isabel; Eriksson, Mikael; Fasching, Peter A.; Figueroa, Jonine; Flyger, Henrik; García-Closas, Montserrat; Giles, Graham G.; Goldberg, Mark S.; González-Neira, Anna; Grenaker-Alnæs, Grethe; Guénel, Pascal; Haeberle, Lothar; Haiman, Christopher A.; Hamann, Ute; Hallberg, Emily; Hooning, Maartje J.; Hopper, John L.; Jakubowska, Anna; Jones, Michael; Kabisch, Maria; Kataja, Vesa; Lambrechts, Diether; Marchand, Loic Le; Lindblom, Annika; Lubinski, Jan; Mannermaa, Arto; Maranian, Mel; Margolin, Sara; Marme, Frederik; Milne, Roger L.; Neuhausen, Susan L.; Nevanlinna, Heli; Neven, Patrick; Olswold, Curtis; Peto, Julian; Plaseska-Karanfilska, Dijana; Pylkäs, Katri; Radice, Paolo; Rudolph, Anja; Sawyer, Elinor J.; Schmidt, Marjanka K.; Shu, Xiao-Ou; Southey, Melissa C.; Swerdlow, Anthony; Tollenaar, Rob A.E.M.; Tomlinson, Ian; Torres, Diana; Truong, Thérèse; Vachon, Celine; Van Den Ouweland, Ans M. W.; Wang, Qin; Winqvist, Robert; Investigators, kConFab/AOCS; Zheng, Wei; Benitez, Javier; Chenevix-Trench, Georgia; Dunning, Alison M.; Pharoah, Paul D. P.; Kristensen, Vessela; Hall, Per; Easton, Douglas F.; Pastinen, Tomi; Nord, Silje; Simard, Jacques

    2016-01-01

    There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an important source of phenotypic variation. Consequently, cis-regulatory SNPs associated with differential allelic expression are functional candidates for further investigation as disease-causing variants. To investigate whether common variants associated with differential allelic expression were involved in breast cancer susceptibility, a list of genes was established on the basis of their involvement in cancer related pathways and/or mechanisms. Thereafter, using data from a genome-wide map of allelic expression associated SNPs, 313 genetic variants were selected and their association with breast cancer risk was then evaluated in 46,451 breast cancer cases and 42,599 controls of European ancestry ascertained from 41 studies participating in the Breast Cancer Association Consortium. The associations were evaluated with overall breast cancer risk and with estrogen receptor negative and positive disease. One novel breast cancer susceptibility locus on 4q21 (rs11099601) was identified (OR = 1.05, P = 5.6x10-6). rs11099601 lies in a 135 kb linkage disequilibrium block containing several genes, including, HELQ, encoding the protein HEL308 a DNA dependant ATPase and DNA Helicase involved in DNA repair, MRPS18C encoding the Mitochondrial Ribosomal Protein S18C and FAM175A (ABRAXAS), encoding a BRCA1 BRCT domain-interacting protein involved in DNA damage response and double-strand break (DSB) repair. Expression QTL analysis in breast cancer tissue showed rs11099601 to be associated with HELQ (P = 8.28x10-14), MRPS18C (P = 1.94x10-27) and FAM175A (P = 3.83x10-3), explaining about 20%, 14% and 1%, respectively of the variance inexpression of these genes in breast carcinomas. PMID:27792995

  17. Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.

    Science.gov (United States)

    Hamdi, Yosr; Soucy, Penny; Adoue, Véronique; Michailidou, Kyriaki; Canisius, Sander; Lemaçon, Audrey; Droit, Arnaud; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Baynes, Caroline; Blomqvist, Carl; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Bonanni, Bernardo; Borresen-Dale, Anne-Lise; Brand, Judith S; Brauch, Hiltrud; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Chang-Claude, Jenny; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Darabi, Hatef; Dennis, Joe; Devilee, Peter; Dörk, Thilo; Dos-Santos-Silva, Isabel; Eriksson, Mikael; Fasching, Peter A; Figueroa, Jonine; Flyger, Henrik; García-Closas, Montserrat; Giles, Graham G; Goldberg, Mark S; González-Neira, Anna; Grenaker-Alnæs, Grethe; Guénel, Pascal; Haeberle, Lothar; Haiman, Christopher A; Hamann, Ute; Hallberg, Emily; Hooning, Maartje J; Hopper, John L; Jakubowska, Anna; Jones, Michael; Kabisch, Maria; Kataja, Vesa; Lambrechts, Diether; Le Marchand, Loic; Lindblom, Annika; Lubinski, Jan; Mannermaa, Arto; Maranian, Mel; Margolin, Sara; Marme, Frederik; Milne, Roger L; Neuhausen, Susan L; Nevanlinna, Heli; Neven, Patrick; Olswold, Curtis; Peto, Julian; Plaseska-Karanfilska, Dijana; Pylkäs, Katri; Radice, Paolo; Rudolph, Anja; Sawyer, Elinor J; Schmidt, Marjanka K; Shu, Xiao-Ou; Southey, Melissa C; Swerdlow, Anthony; Tollenaar, Rob A E M; Tomlinson, Ian; Torres, Diana; Truong, Thérèse; Vachon, Celine; Van Den Ouweland, Ans M W; Wang, Qin; Winqvist, Robert; Zheng, Wei; Benitez, Javier; Chenevix-Trench, Georgia; Dunning, Alison M; Pharoah, Paul D P; Kristensen, Vessela; Hall, Per; Easton, Douglas F; Pastinen, Tomi; Nord, Silje; Simard, Jacques

    2016-12-06

    There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-acting variants represent an important source of phenotypic variation. Consequently, cis-regulatory SNPs associated with differential allelic expression are functional candidates for further investigation as disease-causing variants. To investigate whether common variants associated with differential allelic expression were involved in breast cancer susceptibility, a list of genes was established on the basis of their involvement in cancer related pathways and/or mechanisms. Thereafter, using data from a genome-wide map of allelic expression associated SNPs, 313 genetic variants were selected and their association with breast cancer risk was then evaluated in 46,451 breast cancer cases and 42,599 controls of European ancestry ascertained from 41 studies participating in the Breast Cancer Association Consortium. The associations were evaluated with overall breast cancer risk and with estrogen receptor negative and positive disease. One novel breast cancer susceptibility locus on 4q21 (rs11099601) was identified (OR = 1.05, P = 5.6x10-6). rs11099601 lies in a 135 kb linkage disequilibrium block containing several genes, including, HELQ, encoding the protein HEL308 a DNA dependant ATPase and DNA Helicase involved in DNA repair, MRPS18C encoding the Mitochondrial Ribosomal Protein S18C and FAM175A (ABRAXAS), encoding a BRCA1 BRCT domain-interacting protein involved in DNA damage response and double-strand break (DSB) repair. Expression QTL analysis in breast cancer tissue showed rs11099601 to be associated with HELQ (P = 8.28x10-14), MRPS18C (P = 1.94x10-27) and FAM175A (P = 3.83x10-3), explaining about 20%, 14% and 1%, respectively of the variance inexpression of these genes in breast carcinomas.

  18. MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response.

    Directory of Open Access Journals (Sweden)

    Fabiane Sônego

    Full Text Available Pathogen recognition and triggering of the inflammatory response following infection in mammals depend mainly on Toll-like and Nod-like receptors. Here, we evaluated the role of Nod1, Nod2 and MyD88-dependent signaling in the chemokine production and neutrophil recruitment to the infectious site during sepsis induced by cecal ligation and puncture (CLP in C57Bl/6 mice. We demonstrate that Nod1 and Nod2 are not involved in the release of chemokines and recruitment of neutrophils to the infectious site during CLP-induced septic peritonitis because these events were similar in wild-type, Nod1-, Nod2-, Nod1/Nod2- and Rip2-deficient mice. Consequently, the local and systemic bacterial loads were not altered. Accordingly, neither Nod1 nor Nod2 was involved in the production of the circulating cytokines and in the accumulation of leukocytes in the lungs. By contrast, we showed that MyD88-dependent signaling is crucial for the establishment of the local inflammatory response during CLP-induced sepsis. MyD88-deficient mice were susceptible to sepsis because of an impaired local production of chemokines and defective neutrophil recruitment to the infection site. Altogether, these data show that Nod1, Nod2 and Rip2 are not required for local chemokine production and neutrophil recruitment during CLP-induced sepsis, and they reinforce the importance of MyD88-dependent signaling for initiation of a protective host response.

  19. Formal Devices for Creating New Signs in American Sign Languages.

    Science.gov (United States)

    Bellugi, Ursula; Newkirk, Don

    1981-01-01

    Examines recently coined American Sign Language signs to show how the ASL lexicon is expanded. Included are elicited signs for relatively new objects or ideas, signs referring to metalinguistics concepts in ASL, signs used as jargon or specialized vocabulary, and signs "invented" by young deaf children. (Author/PJM)

  20. High Density Sphere Culture of Adult Cardiac Cells Increases the Levels of Cardiac and Progenitor Markers and Shows Signs of Vasculogenesis

    Directory of Open Access Journals (Sweden)

    Kristina Vukusic

    2013-01-01

    Full Text Available 3D environment and high cell density play an important role in restoring and supporting the phenotypes of cells represented in cardiac tissues. The aim of this study was therefore to investigate the suitability of high density sphere (HDS cultures for studies of cardiomyocyte-, endothelial-, and stem-cell biology. Primary adult cardiac cells from nine human biopsies were cultured using different media for up to 9 weeks. The possibilities to favor a certain cell phenotype and induce production of extra cellular matrix (ECM were studied by histology, immunohistochemistry, and quantitative real-time PCR. Defined media gave significant increase in both cardiac- and progenitor-specific markers and also an intraluminal position of endothelial cells over time. Cardiac media showed indication of differentiation and maturity of HDS considering the ECM production and activities within NOTCH regulation but no additional cardiac differentiation. Endothelial media gave no positive effects on endothelial phenotype but increased proliferation without fibroblast overgrowth. In addition, indications for early vasculogenesis were found. It was also possible to affect the Wnt signaling in HDS by addition of a glycogen synthase kinase 3 (GSK3 inhibitor. In conclusion, these findings show the suitability of HDS as in vitro model for studies of cardiomyocyte-, endothelial-, and stem-cell biology.

  1. Biofilms of Listeria monocytogenes produced at 12 °C either in pure culture or in co-culture with Pseudomonas aeruginosa showed reduced susceptibility to sanitizers.

    Science.gov (United States)

    Lourenço, António; Machado, Henrique; Brito, Luisa

    2011-03-01

    The biofilm-forming ability of 21 Listeria monocytogenes isolates, previously pulsotyped and corresponding to 16 strains, from different origins was evaluated using the Calgary Biofilm Device, at 37 °C. Biofilms of 4 selected strains were also produced either on pure cultures or on co-cultures with Pseudomonas aeruginosa (PAO1), at 12 °C and at 37 °C. For these biofilms, the minimum biofilm eradication concentrations (MBECs) of 4 commercial dairy sanitizers (1 alkyl amine acetate based--T99, 2 chlorine based--T66 and DD, and 1 phosphoric acid based--BP) were determined. Listeria monocytogenes biofilms grown, either at 37 °C or 12 °C, were able to achieve similar cell densities by using different incubation periods (24 h and 7 d, respectively). In co-culture biofilms, P. aeruginosa was the dominant species, either at 37 °C or at 12 °C, representing 99% of a total biofilm population of 6 to 7 log CFU/peg. Co-culture biofilms were generally less susceptible than L. monocytogenes pure cultures. More interestingly, the biofilms produced at 12 °C were usually less susceptible to the sanitizers than when produced at 37 °C. Single or co-culture biofilms of L. monocytogenes and PAO1, particularly produced at 12 °C, retrieved MBEC values for agents T99 and BP that were, at times, above the maximum in-use recommended concentrations for these agents. The results presented here reinforce the importance of the temperature used for biofilm formation, when susceptibility to sanitizers is being assessed. Since most food plants have cold wet growth niches in production and storage areas, susceptibility testing should be performed on biofilms produced at refrigeration temperatures. Moreover, the efficiency of the sanitizers used in food industries should be performed on mixed culture biofilms, since in field conditions these will predominate. The results presented here highlight the importance of the temperature used for biofilm formation, when susceptibility to

  2. The BACHD Rat Model of Huntington Disease Shows Signs of Fronto-Striatal Dysfunction in Two Operant Conditioning Tests of Short-Term Memory.

    Science.gov (United States)

    Clemensson, Erik Karl Håkan; Clemensson, Laura Emily; Riess, Olaf; Nguyen, Huu Phuc

    2017-01-01

    The BACHD rat is a recently developed transgenic animal model of Huntington disease, a progressive neurodegenerative disorder characterized by extensive loss of striatal neurons. Cognitive impairments are common among patients, and characterization of similar deficits in animal models of the disease is therefore of interest. The present study assessed the BACHD rats' performance in the delayed alternation and the delayed non-matching to position test, two Skinner box-based tests of short-term memory function. The transgenic rats showed impaired performance in both tests, indicating general problems with handling basic aspects of the tests, while short-term memory appeared to be intact. Similar phenotypes have been found in rats with fronto-striatal lesions, suggesting that Huntington disease-related neuropathology might be present in the BACHD rats. Further analyses indicated that the performance deficit in the delayed alternation test might be due to impaired inhibitory control, which has also been implicated in Huntington disease patients. The study ultimately suggests that the BACHD rats might suffer from neuropathology and cognitive impairments reminiscent of those of Huntington disease patients.

  3. The BACHD Rat Model of Huntington Disease Shows Signs of Fronto-Striatal Dysfunction in Two Operant Conditioning Tests of Short-Term Memory.

    Directory of Open Access Journals (Sweden)

    Erik Karl Håkan Clemensson

    Full Text Available The BACHD rat is a recently developed transgenic animal model of Huntington disease, a progressive neurodegenerative disorder characterized by extensive loss of striatal neurons. Cognitive impairments are common among patients, and characterization of similar deficits in animal models of the disease is therefore of interest. The present study assessed the BACHD rats' performance in the delayed alternation and the delayed non-matching to position test, two Skinner box-based tests of short-term memory function. The transgenic rats showed impaired performance in both tests, indicating general problems with handling basic aspects of the tests, while short-term memory appeared to be intact. Similar phenotypes have been found in rats with fronto-striatal lesions, suggesting that Huntington disease-related neuropathology might be present in the BACHD rats. Further analyses indicated that the performance deficit in the delayed alternation test might be due to impaired inhibitory control, which has also been implicated in Huntington disease patients. The study ultimately suggests that the BACHD rats might suffer from neuropathology and cognitive impairments reminiscent of those of Huntington disease patients.

  4. Patients lacking sustainable long-term weight loss after gastric bypass surgery show signs of decreased inhibitory control of prepotent responses.

    Directory of Open Access Journals (Sweden)

    Pleunie S Hogenkamp

    Full Text Available A considerable number of bariatric patients report poor long-term weight loss after Roux-en-Y gastric bypass (RYGB surgery. One possibility for an underlying cause is an impairment of cognitive control that impedes this patient group's dietary efforts.To investigate if patients having either poor or good weight loss response, ~12 years after RYGB-surgery, differ in their ability to inhibit prepotent responses when processing food cues during attentional operations-as measure of cognitive control.In terms of weight loss following RYGB-surgery, 15 'poor responders' and 15 'good responders', matched for gender, age, education, preoperative body mass index, and years since surgery, were administered two tasks that measure sustained attention and response control: a go/no-go task and a Stroop interference task; both of which are associated with maladaptive eating behaviours.The poor responders (vs. good responders needed significantly more time when conducting a go/no-go task (603±134 vs. 519±44 msec, p = 0.03, but the number of errors did not differ between groups. When conducting a Stroop interference task, poor responders read fewer inks than good responders (68±16 vs. 85±10 words, p = 0.002.Patients lacking sustainable weight loss after RYGB-surgery showed poorer inhibitory control than patients that successfully lost weight. In the authors' view, these results suggest that cognitive behavioral therapies post-RYGB-surgery may represent a promising behavioral adjuvant to achieve sustainable weight loss in patients undergoing this procedure. Future studies should examine whether these control deficits in poor responders are food-specific or not.

  5. A Pharmacogenetics Study in Mozambican Patients Treated with Nevirapine: Full Resequencing of TRAF3IP2 Gene Shows a Novel Association with SJS/TEN Susceptibility

    Directory of Open Access Journals (Sweden)

    Cinzia Ciccacci

    2015-03-01

    Full Text Available Steven–Johnson Syndrome (SJS and Toxic Epidermal Necrolysis (TEN are severe adverse drug reactions, characterized by extensive epidermal detachment and erosions of mucous membrane. SJS/TEN is one of the most serious adverse reactions to Nevirapine (NVP treatment, commonly used in developing countries as first-line treatment of human immunodeficiency virus infection. In the last years TRAF3IP2 gene variants had been described as associated with susceptibility to several diseases such as psoriasis and psoriatic arthritis. We hypothesized that this gene, involved in immune response and in NF-κB activation, could also be implicated in the SJS/TEN susceptibility. We performed a full resequencing of TRAF3IP2 gene in a population of patients treated with NVP. Twenty-seven patients with NVP-induced SJS/TEN and 78 controls, all from Mozambique, were enrolled. We identified eight exonic and three intronic already described variants. The case/control association analysis highlighted an association between the rs76228616 SNP in exon 2 and the SJS/TEN susceptibility. In particular, the variant allele (C resulted significantly associated with a higher risk to develop SJS/TEN (p = 0.012 and OR = 3.65 (95% CI 1.33–10.01. A multivariate analysis by logistic regression confirmed its significant contribution (p = 0.027, OR = 4.39 (95% CI 1.19–16.23. In conclusion, our study suggests that a variant in TRAF3IP2 gene could be involved in susceptibility to SJS/TEN.

  6. A pharmacogenetics study in Mozambican patients treated with nevirapine: full resequencing of TRAF3IP2 gene shows a novel association with SJS/TEN susceptibility.

    Science.gov (United States)

    Ciccacci, Cinzia; Rufini, Sara; Mancinelli, Sandro; Buonomo, Ersilia; Giardina, Emiliano; Scarcella, Paola; Marazzi, Maria C; Novelli, Giuseppe; Palombi, Leonardo; Borgiani, Paola

    2015-03-12

    Steven-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe adverse drug reactions, characterized by extensive epidermal detachment and erosions of mucous membrane. SJS/TEN is one of the most serious adverse reactions to Nevirapine (NVP) treatment, commonly used in developing countries as first-line treatment of human immunodeficiency virus infection. In the last years TRAF3IP2 gene variants had been described as associated with susceptibility to several diseases such as psoriasis and psoriatic arthritis. We hypothesized that this gene, involved in immune response and in NF-κB activation, could also be implicated in the SJS/TEN susceptibility. We performed a full resequencing of TRAF3IP2 gene in a population of patients treated with NVP. Twenty-seven patients with NVP-induced SJS/TEN and 78 controls, all from Mozambique, were enrolled. We identified eight exonic and three intronic already described variants. The case/control association analysis highlighted an association between the rs76228616 SNP in exon 2 and the SJS/TEN susceptibility. In particular, the variant allele (C) resulted significantly associated with a higher risk to develop SJS/TEN (p = 0.012 and OR = 3.65 (95% CI 1.33-10.01)). A multivariate analysis by logistic regression confirmed its significant contribution (p = 0.027, OR = 4.39 (95% CI 1.19-16.23)). In conclusion, our study suggests that a variant in TRAF3IP2 gene could be involved in susceptibility to SJS/TEN.

  7. Susceptibilities and Spin Gaps of Weakly Coupled Spin Ladders

    Energy Technology Data Exchange (ETDEWEB)

    Larochelle, S.

    2004-05-11

    We calculate the uniform and staggered susceptibilities of two-chain spin-1/2 Heisenberg ladders using Monte-Carlo simulations. We show that the gap extracted from the uniform susceptibility and the saturation value of the staggered susceptibility are independent of the sign of the interchain coupling J{perpendicular} in the asymptotic limit |J{perpendicular}|/J {yields} 0. Furthermore, we examine the existence of logarithmic corrections to the linear scaling of the gap with |J{perpendicular}|.

  8. The comparative analysis of anatomical traits of four largefruited hazelnut cultivars showing different susceptibility to filbert aphid (Myzocallis coryli Goetze feeding

    Directory of Open Access Journals (Sweden)

    Elżbieta Weryszko-Chmielewska

    2012-12-01

    Full Text Available Investigations related to morphological and anatomical traits of leaves of four largefruited hazelnut (Corylus L. cultivars characterised by different susceptibility to filbert aphid (Myzocallis coryli Goetze feeding. The following parameters were measured: the thickness of leaf blade, the number of stomata, the length of secretory and mechanical hairs and their density on the leaf, the thickness of adaxial and abaxial epidermis and the thickness of their external cell walls. Observations of cross sections of the leaves were made in a light microscope and the surface of the adaxial epidermis was analysed in a scanning electron microscope. It was shown that leaves of the cultivars susceptible to M. coryli feeding had the thinnest leaf blade, especially in the main vein, and many more stomata. Besides, the cultivar most resistant to filbert aphid feeding, White Filbert, was marked by the largest height of the adaxial epidermis cells and the strongest striation of the cuticle in abaxial epidermis. On leaves of this cultivar, the number of mechanical hairs was the highest, while the lowest number of them was noted on Wonder from Bollwiller, the most susceptible cultivar.

  9. SOLiD SAGE sequencing shows differential gene expression in jejunal lymph node samples of resistant and susceptible red deer (Cervus elaphus) challenged with Mycobacterium avium subsp. paratuberculosis.

    Science.gov (United States)

    Mackintosh, C G; Griffin, J F T; Scott, I C; O'Brien, R; Stanton, J L; MacLean, P; Brauning, R

    2016-01-01

    This study compared in vivo lymph node gene expression levels between six young red deer that were either relatively resistant (R) or susceptible (S) to paratuberculosis following experimental challenge with Mycobacterium avium subsp. paratuberculosis. Intestinal lymph nodes were biopsied at 4, 12 and 50 weeks post challenge (pc) and parallel changes in histopathology, immunology and bacterial load monitored. SOLiD SAGE (serial analysis of gene expression) next generation sequencing of biopsied lymph node samples generated a total of 373 million transcript tags 26-28bp in length after filtering. A total of 36,632 unique transcripts were identified and 14,325 of these were able to be annotated. The copy number of each transcript was counted, averaged and compared for R and S animals (R-S). P values and False Discovery Rates (FDR) were calculated for each transcript. Genes differentially upregulated ≥2 fold (FDR<0.5) totalled 9, 40 and 32 in R animals (+ values) and 23, 164 and 47 in S animals (- values) at weeks 4, 12, and 50pc, respectively. Transcripts displaying greatest differential expression between R and S animals at each time point were IFIT2 (189 fold) and S100A8 (-32.7 fold) at week 4, LRR1 (52.7 fold), SERPINF2 (-214.6 fold) at week 12 and CEACAM8 (84.6 fold), and STK31 (-129.5 fold) at week 50, respectively. All 9 genes significantly upregulated at week 4 in R animals relate specifically to host defence and all involve Type I interferon stimulated genes. By contrast genes upregulated in S animals at week 4, relate predominantly to inflammation, but also involve adaptive immune responses, mitochondrial function and apoptosis regulation. At week 12, the genes differentially upregulated in R animals are linked predominantly to regulation of adaptive immunity and mucosal immunity, while many of the genes in S animals are associated with pro-inflammatory interleukins involved with innate and adaptive immunity. These correlated with greater lesion severity

  10. Signes Iconiques, Signes Linguistiques (Iconic Signs, Linguistic Signs)

    Science.gov (United States)

    Besse, Henri

    1974-01-01

    This article discusses the audiovisual image as sign; the classification of signs according to two different semiologies, and two different semantic theories; and the relation to different pedagogical approaches. (Text is in French.) (AM)

  11. Liofilchem(®) Chromatic VRE and vancomycin MIC Test Strip detected glycopeptide resistance in a vanB neonatal Enterococcus faecium isolate showing alternate vancomycin susceptibility and resistance with bioMérieux Vitek2.

    Science.gov (United States)

    Savini, Vincenzo; Marrollo, Roberta; Coclite, Eleonora; Fusilli, Paola; D'Incecco, Carmine; Fazii, Paolo; Gherardi, Giovanni

    2014-01-01

    A 1-month old neonate urine sample yielded vanB Enterococcus faecium; nevertheless, the isolate alternatively showed susceptibility and resistance to vancomycin with bioMérieux Vitek2 (cards AST592, AST632, AST586), while glycopeptide resistance was detected by Liofilchem(®) vancomycin MIC Test Strip and disc along with the Chromatic VRE chromogenic medium. This communication emphasizes that, as vanB gene may be heterogeneously expressed within a given Enterococcus population, glycopeptide resistance may be missed when using automated systems for antibiotic susceptibility testing. We suggest therefore that vancomycin in vitro activity be studied on all clinical isolates through agar methods, including use of chromogenic media.

  12. Increased susceptibility of skin from HERDA (Hereditary Equine Regional Dermal Asthenia)-affected horses to bacterial collagenase degradation: a potential contributing factor to the clinical signs of HERDA.

    Science.gov (United States)

    Rashmir-Raven, Ann; Lavagnino, Michael; Sedlak, Aleksa; Gardner, Keri; Arnoczky, Steven

    2015-12-01

    Hereditary equine regional dermal asthenia (HERDA) is a genetic disorder of collagen resulting in fragile, hyper-extensible skin and ulcerative lesions. The predominance of skin lesions have been shown to occur on the dorsum of HERDA-affected horses. While this has been postulated to be due to increased exposure to sunlight of these areas, the precise pathological mechanism which causes this to occur is unclear. We hypothesized that an increase in collagenase activity, that has been associated with the exposure of dermal fibroblasts to sunlight, will significantly degrade the material properties of skin from HERDA-affected horses when compared to unaffected controls. Six unaffected and seven HERDA-affected horses, all euthanized for other reasons. Full-thickness skin samples from similar locations on each horse were collected and cut into uniform strips and their material properties (tensile modulus) determined by mechanical testing before (n = 12 samples/horse) or after (n = 12 samples/horse) incubation in bacterial collagenase at 37°C for 6 h. The change in modulus following treatment was then compared between HERDA-affected and unaffected horses using a Student's t-test. The modulus of skin from HERDA-affected horses decreased significantly more than that from unaffected horses following collagenase treatment (54 ± 7% versus 30 ± 16%, P = 0.004). The significant decrease in the modulus of skin from HERDA-affected horses following collagenase exposure suggests that their altered collagen microarchitecture is more susceptible to enzymatic degradation and may explain the localization of skin lesions in HERDA-affected horses to those areas of the body most exposed to sunlight. These findings appear to support the previously reported benefits of sunlight restriction in HERDA-affected horses. © 2015 ESVD and ACVD.

  13. Fludeoxyglucose positron emission tomography-computed tomography scan showing polyarthritis in a patient with an atypical presentation of Henoch-Schönlein vasculitis without clinical signs of arthritis: a case report.

    Science.gov (United States)

    Mooij, Christiaan F; Hermsen, Rick; Hoppenreijs, Esther P A H; Bleeker-Rovers, Chantal P; IJland, Marloes M; de Geus-Oei, Lioe-Fee

    2016-06-02

    Henoch-Schönlein vasculitis is the most common systemic vasculitis in children. Arthritis or arthralgia occurs in 80 % of patients. We believe this to be the first case report to describe the finding of polyarthritis in a fludeoxyglucose positron emission tomography-computed tomography scan in a patient with Henoch-Schönlein vasculitis without clinical signs of arthritis. A 4.5-year-old Caucasian boy presented with fever of 4 days' duration followed by debilitating migratory arthralgia and inflammation. He underwent a fludeoxyglucose positron emission tomography-computed tomography scan to exclude a possible malignant cause or to detect any infectious or autoimmune focus of his symptoms. Fludeoxyglucose uptake was observed in multiple large joints and in multiple tendons. These findings suggested active polyarthritis and polytendinitis. However, physical and ultrasound evaluations did not show any signs of arthritis in our patient, despite his evident arthralgia. Fludeoxyglucose positron emission tomography-computed tomography might be able to detect inflammatory activity in painful joints that cannot yet be detected clinically or with ultrasound evaluation in a patient with Henoch-Schönlein vasculitis. Therefore, fludeoxyglucose positron emission tomography-computed tomography can be of additional value in the diagnostic workup of patients with an unresolved diagnosis of suspected autoimmune disease, especially in patients with unresolved arthralgia and fever of unknown cause.

  14. Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN

    Science.gov (United States)

    Gillespie, Leah; Roosendahl, Paula; Ng, Wy Ching; Brooks, Andrew G.; Reading, Patrick C.; Londrigan, Sarah L.

    2016-01-01

    The ubiquitous presence of cell-surface sialic acid (SIA) has complicated efforts to identify specific transmembrane glycoproteins that function as bone fide entry receptors for influenza A virus (IAV) infection. The C-type lectin receptors (CLRs) DC-SIGN (CD209) and L-SIGN (CD209L) enhance IAV infection however it is not known if they act as attachment factors, passing virions to other unknown receptors for virus entry, or as authentic entry receptors for CLR-mediated virus uptake and infection. Sialic acid-deficient Lec2 Chinese Hamster Ovary (CHO) cell lines were resistant to IAV infection whereas expression of DC-SIGN/L-SIGN restored susceptibility of Lec2 cells to pH- and dynamin-dependent infection. Moreover, Lec2 cells expressing endocytosis-defective DC-SIGN/L-SIGN retained capacity to bind IAV but showed reduced susceptibility to infection. These studies confirm that DC-SIGN and L-SIGN are authentic endocytic receptors for IAV entry and infection. PMID:26763587

  15. Toward the Ideal Signing Avatar

    Directory of Open Access Journals (Sweden)

    Nicoletta Adamo-Villani

    2016-06-01

    Full Text Available The paper discusses ongoing research on the effects of a signing avatar's modeling/rendering features on the perception of sign language animation. It reports a recent study that aimed to determine whether a character's visual style has an effect on how signing animated characters are perceived by viewers. The stimuli of the study were two polygonal characters presenting two different visual styles: stylized and realistic. Each character signed four sentences. Forty-seven participants with experience in American Sign Language (ASL viewed the animated signing clips in random order via web survey. They (1 identified the signed sentences (if recognizable, (2 rated their legibility, and (3 rated the appeal of the signing avatar. Findings show that while character's visual style does not have an effect on subjects' perceived legibility of the signs and sign recognition, it has an effect on subjects' interest in the character. The stylized signing avatar was perceived as more appealing than the realistic one.

  16. Antimicrobial susceptibility of Staphylococcus aureus isolated from children with impetigo in China from 2003 to 2007 shows community-associated methicillin-resistant Staphylococcus aureus to be uncommon and heterogeneous.

    Science.gov (United States)

    Liu, Y; Kong, F; Zhang, X; Brown, M; Ma, L; Yang, Y

    2009-12-01

    The number of patients with impetigo caused by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been increasing. To investigate the antimicrobial susceptibility of S. aureus causing impetigo in children in China from 2003 to 2007 and further characterize isolates of CA-MRSA. We examined 984 S. aureus isolates for antimicrobial susceptibility to 11 antimicrobials using the agar dilution method. CA-MRSA isolates were analysed for Panton-Valentine leucocidin (PVL) genes, and staphylococcal cassette chromosome mec (SCCmec) typing was performed. The largest proportion (94.5%) of strains were resistant to penicillin, followed by erythromycin (86.2%) and clindamycin (69.6%). In total 772 of 984 (78.5%) S. aureus strains were multiresistant. The incidence of CA-MRSA was 1.1%, with a high rate of resistance to clindamycin (90.9%) and tetracycline (72.7%), but all were susceptible to ciprofloxacin. The susceptibility profiles of MRSA to other antimicrobial agents were similar to those of methicillin-sensitive S. aureus (MSSA). None of the S. aureus strains were resistant to vancomycin and fusidic acid; moreover, only one strain was resistant to mupirocin. Typing of the SCCmec showed that 54.5% were type IV, 18.2% were type V and 9.1% were type VI. All the PVL-positive CA-MRSA carried SCCmec type IV. CA-MRSA is still relatively uncommon and heterogeneous in children in China. Penicillin and erythromycin are no longer appropriate agents. Effective antibiotic agents for patients with impetigo are mupirocin and fusidic acid.

  17. Sign language: an international handbook

    NARCIS (Netherlands)

    Pfau, R.; Steinbach, M.; Woll, B.

    2012-01-01

    Sign language linguists show here that all the questions relevant to the linguistic investigation of spoken languages can be asked about sign languages. Conversely, questions that sign language linguists consider - even if spoken language researchers have not asked them yet - should also be asked of

  18. American Sign Language

    Science.gov (United States)

    ... Health Info » Voice, Speech, and Language American Sign Language On this page: What is American Sign Language? ... signs "I love you." What is American Sign Language? American Sign Language (ASL) is a complete, complex ...

  19. Visual ergonomic evaluations on four different designs of LED traffic signs

    Science.gov (United States)

    Chen, Yi-Chun; Huang, Ting-Yuan; Lee, Tsung-Xian; Sun, Ching-Cherng

    2017-08-01

    To investigate the legibility and visual comfort of LED traffic signs, an ergonomic experiment is performed on four custom-designed LED traffic signs, including three self-luminous ones as LED lightbox, LED backlight and regional LED backlight, and one non-self-luminous sign with external LED lighting. The four signs are hanged side-by-side and evaluated by observers through questionnaires. The signage dimension is one-sixth of the real freeway traffic signs, and the observation distance is 25 m. The luminance of three self-luminous signs is 216 cd/m2. The illuminance of external LED lighting is 400 lux on the traffic sign. The ambient illuminance is 2.8 and 6.0 lux in two rounds. The results show that self-luminous traffic signs provide superior legibility, visual comfort and user preference than the non-self-luminous one. Among the three self-luminous signs, regional LED backlight is most susceptible to the ambient illumination. LED lightbox has significantly better preference score than LED backlight under darker ambient lighting. Only LED lightbox has significantly better visual comfort than external LED lighting in the brighter environment. Based on the four LED traffic signs evaluated in this study, we suggest LED lightbox as the prior choice. Further investigations on the effect of ambient illumination and other designs of self-luminous traffic signs are in progress.

  20. Heed the signs: Operation signs have spatial associations.

    Science.gov (United States)

    Pinhas, Michal; Shaki, Samuel; Fischer, Martin H

    2014-01-01

    Mental arithmetic shows systematic spatial biases. The association between numbers and space is well documented, but it is unknown whether arithmetic operation signs also have spatial associations and whether or not they contribute to spatial biases found in arithmetic. Adult participants classified plus and minus signs with left and right button presses under two counterbalanced response rules. Results from two experiments showed that spatially congruent responses (i.e., right-side responses for the plus sign and left-side responses for the minus sign) were responded to faster than spatially incongruent ones (i.e., left-side responses for the plus sign and right-side responses for the minus sign). We also report correlations between this novel operation sign spatial association (OSSA) effect and other spatial biases in number processing. In a control experiment with no explicit processing requirements for the operation signs there were no sign-related spatial biases. Overall, the results suggest that (a) arithmetic operation signs can evoke spatial associations (OSSA), (b) experience with arithmetic operations probably underlies the OSSA, and (c) the OSSA only partially contributes to spatial biases in arithmetic.

  1. Baldwin Borough Signs

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — An inventory by location of the signs on Borough of Baldwin roads and properties, such as street signs, traffic signs, and warning signs.

  2. Differences in the susceptibility of dromedary and Bactrian camels to foot-and-mouth disease virus

    DEFF Research Database (Denmark)

    Larska, M.; Wernery, U.; Kinne, J.

    2009-01-01

    as positive controls, displayed typical moderate clinical signs of FMD and developed viraemia and high antibody titres. The presence of the virus was also detected in probang and mouth-swab samples for several days after inoculation. In contrast, the inoculated dromedary camels were not susceptible to FMDV...... type A infection. None of them showed clinical signs of FMD or developed viraemia or specific anti-FMDV antibodies despite the high dose of virus inoculated. All the contact sheep and contact dromedaries that were kept together with the inoculated camels remained virus-negative and did not seroconvert...... when tested up to 28 days post-inoculation (p.i.). In comparison with the non-susceptible dromedaries, the two inoculated Bactrian camels showed moderate to severe clinical signs of FMD; however, the clinical signs of FMD appeared rather late, between 8 and 14 days p.i., compared to the inoculated...

  3. Risk for HIV-1 infection is not associated with repeat-region polymorphism in the DC-SIGN neck domain and novel genetic DC-SIGN variants among North Indians.

    Science.gov (United States)

    Rathore, Anurag; Chatterjee, Animesh; Sood, Vikas; Khan, Sohrab Z; Banerjea, Akhil C; Yamamoto, Naohiko; Dhole, Tapan N

    2008-05-01

    Several genetic factors have been related to HIV-1 resistance, the homozygosity for a mutation in CCR5 gene (CCR5Delta 32 allele) is presently considered the most relevant one. The C-type lectin, DC-SIGN efficiently binds and transmits HIV-1 to susceptible cell in trans thereby augmenting the infection. A potential association of the DC-SIGN neck domain repeats polymorphism and risk of HIV-1 infection is currently under debate. Genetic risk association study was conducted in HIV-1 exposed seronegative (HES; n=50) individuals, HIV-1 seronegative (HSN; n=314) healthy control and HIV-1 infected seropositive patients (HSP; n=190) for polymorphism in neck domain of DC-SIGN gene. The DC-SIGN genotypes were identified by PCR from DNA extracted from peripheral blood and confirmed by sequencing. Fisher exact or chi(2) test was used for statistical analysis. One HSN and HSP individual who were heterozygous (7/8) with respect to DC-SIGN repeat regions were found. The DC-SIGN neck repeat polymorphism among North Indian individuals was not associated with susceptibility to HIV-1 infection. Furthermore, inheritance study of heterozygous mutation (7/8) in HSN individual's family showed that one parent, two brothers, one sister and one daughter were heterozygous (7/8) for DC-SIGN mutant allele. Sequence analyses of DC-SIGN exon 4 repeat region of randomly selected 25 North Indian individuals from HSP, HSN and HES revealed four conserved intronic mutations. These mutations were at nucleotide position 1283, 1306, 1308 upstream and 1906 downstream of the DC-SIGN exon 4 repeat region when compared with the wild type sequence (NCBI Acc. No. AF209479). The polymorphism in DC-SIGN neck repeats region was rare and not associated with HIV-1 susceptibility among North Indians. Sequencing analysis of DC-SIGN gene confirmed four novel genetic variants in intronic region flanking exon 4 coding region.

  4. Signing off

    Science.gov (United States)

    2001-09-01

    Physics Related Aptitude Test As the teacher shortage bites anyone with a degree in science expects to walk into a school and be received, with open arms, as a physics teacher. Are they really suitable? To help you decide Signing Off provides the following invaluable psychometric test. Extensively researched and, for single users only, it comes completely free to Physics Education subscribers! (Copies of this Physics Related Aptitude Test are available to credit-card customers from prat@realripoff.com priced #35 per client, 125 dollars to US customers.) This invaluable psychometric test has been extensively researched. Your first lesson of the new school year introduces the study of electricity. Do you: A Use the notes prepared by your predecessor. B Find a video on electricity and play it to the class. C Arrange a series of exciting practical demonstrations to stimulate the young inquiring mind. D Let the children design and make their own circuits to light flashlight bulbs. Your 14-year-olds have completed a written test on heat and energy. Do you: A Mark correct only the work of students who have written their names neatly at the top LEFT HAND corner, as required. B Only set multiple choice tests, so that the computer can mark them for you. C Mark carefully by hand, explaining in detail to each student exactly how and why they have made errors and adding encouraging comments with lots of praise. D Give out correct sets of answers and allow students to mark their own work. There is a staff social. Do you: A Ask for a definition of the term 'social'. B Ask for a web-based version. C Determine to go, so that you can discuss setting up cross-curricular links with colleagues. D Join the organizing committee. Who do you admire most? A Sir Isaac Newton. B Bill Gates. C Leonardo da Vinci. D Leonardo di Caprio. You are required to teach biology class. Your response is: A Denial. B To ask for an appropriate computer simulation. C To attend a specialized course for biology

  5. Epidemic spreading on evolving signed networks

    CERN Document Server

    Saeedian, M; Jafari, G R; Kertesz, J

    2016-01-01

    Most studies of disease spreading consider the underlying social network as obtained without the contagion, though epidemic influences peoples willingness to contact others: A friendly contact may be turned to unfriendly to avoid infection. We study the susceptible-infected (SI) disease spreading model on signed networks, in which each edge is associated with a positive or negative sign representing the friendly or unfriendly relation between its end nodes. In a signed network, according to Heiders theory, edge signs evolve such that finally a state of structural balance is achieved, corresponding to no frustration in physics terms. However, the danger of infection affects the evolution of its edge signs. To describe the coupled problem of the sign evolution and disease spreading, we generalize the notion of structural balance by taking into account the state of the nodes. We introduce an energy function and carry out Monte-Carlo simulations on complete networks to test the energy landscape, where we find loc...

  6. Marijuana Usage and Hypnotic Susceptibility

    Science.gov (United States)

    Franzini, Louis R.; McDonald, Roy D.

    1973-01-01

    Anonymous self-reported drug usage data and hypnotic susceptibility scores were obtained from 282 college students. Frequent marijuana users (more than 10 times) showed greater susceptibility to hypnosis than nonusers. (Author)

  7. Warning Signs After Birth

    Science.gov (United States)

    ... Pregnancy > Postpartum care > Warning signs after birth Warning signs after birth E-mail to a friend Please ... infection Postpartum bleeding Postpartum depression (PPD) What warning signs should you look for? Call your provider if ...

  8. Relative Hypodense Vertebral Artery Sign on Computerized Tomography in Atherosclerotic Near Occlusion

    Directory of Open Access Journals (Sweden)

    Muhammad Faraz Raghib

    2016-01-01

    Full Text Available A 52-year-old white male presented with an acute onset of slurred speech along with hypoesthesia in the entire left arm. The acute computed tomography (CT showed relative hypodensity in the intracranial segment of left vertebral artery (VA that was not present in historical images, pointing to the possible lack of flow. The site of occlusion was confirmed by magnetic resonance imaging (MRI that showed susceptibility effect in the affected artery. By means of historical native CT comparison the site of VA thrombosis was correctly predicted. Local atherosclerotic thrombosis of the VA could be relatively hypodense on native CT and still have positive susceptibility weighted imaging (SWI sign.

  9. Phonological development in hearing learners of a sign language: The role of sign complexity and iconicity

    NARCIS (Netherlands)

    Ortega, G.; Morgan, G.

    2015-01-01

    The present study implemented a sign-repetition task at two points in time to hearing adult learners of British Sign Language and explored how each phonological parameter, sign complexity, and iconicity affected sign production over an 11-week (22-hour) instructional period. The results show that

  10. Phonological development in hearing learners of a sign language: the role of sign complexity and iconicity

    NARCIS (Netherlands)

    Ortega, G.; Morgan, G.

    2015-01-01

    The present study implemented a sign-repetition task at two points in time to hearing adult learners of British Sign Language and explored how each phonological parameter, sign complexity, and iconicity affected sign production over an 11-week (22-hour) instructional period. The results show that

  11. Diagnosing Dementia—Positive Signs

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Diagnosing Dementia—Positive Signs Past Issues / Fall 2007 Table of ... easy, affordable blood test that could accurately diagnose Alzheimer's disease (AD)—even before symptoms began to show? Researchers ...

  12. Dense MCA Sign

    Directory of Open Access Journals (Sweden)

    Richard J Chen

    2017-07-01

    Full Text Available History of present illness: A 77-year-old female presented to the emergency department after being found down at home, last seen normal 7 ½ hours prior to arrival. Patient had a history of hypertension, congestive heart failure, atrial fibrillation and breast cancer status post chemotherapy/radiation and lumpectomy. Physical exam showed right gaze preference, left facial droop and tongue deviation and flaccid left hemiplegia. Significant findings: A non-contrast computed tomography (CT scan showed a hyperdensity along the right middle cerebral artery (MCA consistent with acute thrombus. The red arrow highlights the hyperdensity in the annotated image. Discussion: The dense MCA sign can serve as an important tool in the diagnosis of acute stroke. It typically appears before other signs of infarct are apparent on CT imaging, and identifies an intracranial large artery occlusion and corresponding infarct, in the correct clinical setting.1 Calcifications in the same area of the brain could be mistaken for an MCA sign, but this sign carries a high specificity (95% and lower sensitivity (52% for arterial obstruction in ischemic stroke.2 Early identification allows for a wider array of treatment options for a patient with an ischemic stroke, including intra-venous or intra-arterial thrombolysis and mechanical thrombectomy. This patient was subsequently taken for mechanical thrombectomy. Mechanical thrombectomy was chosen for this patient because the resources were available, and recent clinical trials have shown that newer types of mechanical thrombectomy have a positive functional outcome in patients with an ischemic stroke from an intracranial large artery occlusion, as compared to intravenous tissue plasminogen activator (tPa alone.3,4,5,6 In facilities lacking the capability for mechanical thrombectomy, treatment considerations include rapid transfer to a facility with capability, or proceeding with intravenous tPa. After intervention, this

  13. Microbiological screening of Irish patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy reveals persistence of Candida albicans strains, gradual reduction in susceptibility to azoles, and incidences of clinical signs of oral candidiasis without culture evidence.

    LENUS (Irish Health Repository)

    McManus, Brenda A

    2011-05-01

    Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) are prone to chronic mucocutaneous candidiasis, which is often treated with azoles. The purpose of this study was to characterize the oral Candida populations from 16 Irish APECED patients, who comprise approximately half the total number identified in Ireland, and to examine the effect of intermittent antifungal therapy on the azole susceptibility patterns of Candida isolates. Patients attended between one and four clinical evaluations over a 5-year period, providing oral rinses and\\/or oral swab samples each time. Candida was recovered from 14\\/16 patients, and Candida albicans was the only Candida species identified. Interestingly, clinical diagnosis of candidiasis did not correlate with microbiological evidence of Candida infection at 7\\/22 (32%) clinical assessments. Multilocus sequence typing analysis of C. albicans isolates recovered from the same patients on separate occasions identified the same sequence type each time. Fluconazole resistance was detected in isolates from one patient, and isolates exhibiting a progressive reduction in itraconazole and\\/or fluconazole susceptibility were identified in a further 3\\/16 patients, in each case correlating with the upregulation of CDR- and MDR-encoded efflux pumps. Mutations were also identified in the ERG11 and the TAC1 genes of isolates from these four patients; some of these mutations have previously been associated with azole resistance. The findings suggest that alternative Candida treatment options, other than azoles such as chlorhexidine, should be considered in APECED patients and that clinical diagnosis of oral candidiasis should be confirmed by culture prior to the commencement of anti-Candida therapy.

  14. The Forbidden Signs

    DEFF Research Database (Denmark)

    Kilstrup, Mogens

    2016-01-01

    is an important addition that offers insight into the hardware requirements for bio-semiosis. As any type of semiosis must be dependent upon Semiotic scaffolds, I recently argued that the process of semiosis has to be divided into two separate processes of sign establishment and sign interpretation......, and that misalignment between the two processes result in faulty sign interpretation and over-signification. Such faulty signs were forbidden in the sign classification system of Peirce, so I defined them as forbidden signs. Here I present an analysis of the forbidden sign categories with examples from Occult semiotics...... as the combination of two processes; one leading to diversity generation within semiotic scaffolds followed by a second process of decimation of faulty signs during selection in specific learning environments. The analysis suggests that forbidden signs are always used as early stages in the iterative sign...

  15. NASA's Space Biology Program Shows Signs of Life

    Science.gov (United States)

    Nowak, Rachel

    1995-04-01

    Houston-At the first Life Sciences and Space Medicine Conference, held here from 3 to 5 April, NASA Administrator Daniel Goldin made it clear that NASA's life sciences program is not exempt from his drive to reinvent the space agency. "We've got to do things differently to get to our goal" of making long-duration space travel a reality, he told the audience. He stressed "rigorous peer review," collaboration with investigators at the National Institutes of Health and in industry, and the development of commercial spin-offs. Once NASA's overhaul is complete, "life sciences will be the jewel in the crown," Goldin told Science. But as the meeting revealed, there are already some bright spots.

  16. Debate over Social Studies Shows Little Sign of Abating

    Science.gov (United States)

    Robelen, Erik W.

    2010-01-01

    The Texas board of education which consists of 15-member elected body drew national attention as a bloc of staunch conservatives largely succeeded in putting its stamp on a revised set of social studies standards. The debate was marked by tussles over such matters as the separation of church and state, the representation of minority figures and…

  17. Sign Language Interpreters' Training

    OpenAIRE

    Andriakopoulou, Eirini; Bouras, Christos; Giannaka, Eri

    2007-01-01

    Nowadays, the evolution of technology and the increasing use of computers gave the opportunity for developing new methods of education of deaf individuals and sign language interpreters. The e-learning environments that have been developed for the education of sign language provide web-based courses, designed to effectively teach to anyone the Sign Language. Recognizing the difficulties and barriers of sign language training as well as the importance of sign language interpreters for the comm...

  18. Redefining the Pulvinar Sign in Fabry Disease.

    Science.gov (United States)

    Cocozza, S; Russo, C; Pisani, A; Olivo, G; Riccio, E; Cervo, A; Pontillo, G; Feriozzi, S; Veroux, M; Battaglia, Y; Concolino, D; Pieruzzi, F; Mignani, R; Borrelli, P; Imbriaco, M; Brunetti, A; Tedeschi, E; Palma, G

    2017-12-01

    The pulvinar sign refers to exclusive T1WI hyperintensity of the lateral pulvinar. Long considered a common sign of Fabry disease, the pulvinar sign has been reported in many pathologic conditions. The exact incidence of the pulvinar sign has never been tested in representative cohorts of patients with Fabry disease. The aim of this study was to assess the prevalence of the pulvinar sign in Fabry disease by analyzing T1WI in a large Fabry disease cohort, determining whether relaxometry changes could be detected in this region independent of the pulvinar sign positivity. We retrospectively analyzed brain MR imaging of 133 patients with Fabry disease recruited through specialized care clinics. A subgroup of 26 patients underwent a scan including 2 FLASH sequences for relaxometry that were compared with MRI scans of 34 healthy controls. The pulvinar sign was detected in 4 of 133 patients with Fabry disease (3.0%). These 4 subjects were all adult men (4 of 53, 7.5% of the entire male population) with renal failure and under enzyme replacement therapy. When we tested for discrepancies between Fabry disease and healthy controls in quantitative susceptibility mapping and relaxometry maps, no significant difference emerged for any of the tested variables. The pulvinar sign has a significantly lower incidence in Fabry disease than previously described. This finding, coupled with a lack of significant differences in quantitative MR imaging, allows hypothesizing that selective involvement of the pulvinar is a rare neuroradiologic sign of Fabry disease. © 2017 by American Journal of Neuroradiology.

  19. Sanal Lidzhiev, Signs and Omens

    OpenAIRE

    Gedeeva, Darina; Ubushieva, Bamba

    2017-01-01

    Seeing a hare is a good sign, because your plans will materialize. It is a bad sign to see a fox or a corsac on the road. It is also a bad sign when children snort. It is forbidden for pregnant women to eat long intestines or mildly cooked meat with blood. Only one person can eat a cooked sheep's head. If two people eat the same head, they will quarrel. A sheep's head that people present to each other at weddings should be burnt on a fire. If someone brings meat, show it to all who are pres...

  20. MOLAR TOOTH SIGN - JOUBERT SYNDROME

    Directory of Open Access Journals (Sweden)

    Dušica Ranđelović

    2015-09-01

    Full Text Available The molar tooth sign is seen in very few conditions and is a very rare pediatric central nervous system congenital anomaly. Molar tooth sign is the result of cerebellar vermis hypoplasia, thick and maloriented superior cerebellar peduncles, and an abnormally deep interpeduncular fossa. In Joubert syndrome, this is seen in about 85% of patients. We present a case of a two-year old girl with flaccid paraparesis, regression of milestones and developmental delay. Magnetic resonance imaging (MRI showed the characteristic molar tooth sign with apposition of cerebellar hemispheres, batwing-shaped fourth ventricle, cerebellar vermis agenesis and deep interpeduncular fossa consistent with the diagnosis of Joubert syndrome.

  1. 27 CFR 19.280 - Signs.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Signs. 19.280 Section 19... TREASURY LIQUORS DISTILLED SPIRITS PLANTS Construction, Equipment and Security § 19.280 Signs. The proprietor shall place and keep conspicuously on the outside of his place of business a sign showing the name...

  2. Dictionaries of African Sign Languages: An Overview

    Science.gov (United States)

    Schmaling, Constanze H.

    2012-01-01

    This article gives an overview of dictionaries of African sign languages that have been published to date most of which have not been widely distributed. After an introduction into the field of sign language lexicography and a discussion of some of the obstacles that authors of sign language dictionaries face in general, I will show problems…

  3. Epidemic spreading on evolving signed networks

    Science.gov (United States)

    Saeedian, M.; Azimi-Tafreshi, N.; Jafari, G. R.; Kertesz, J.

    2017-02-01

    Most studies of disease spreading consider the underlying social network as obtained without the contagion, though epidemic influences people's willingness to contact others: A "friendly" contact may be turned to "unfriendly" to avoid infection. We study the susceptible-infected disease-spreading model on signed networks, in which each edge is associated with a positive or negative sign representing the friendly or unfriendly relation between its end nodes. In a signed network, according to Heider's theory, edge signs evolve such that finally a state of structural balance is achieved, corresponding to no frustration in physics terms. However, the danger of infection affects the evolution of its edge signs. To describe the coupled problem of the sign evolution and disease spreading, we generalize the notion of structural balance by taking into account the state of the nodes. We introduce an energy function and carry out Monte Carlo simulations on complete networks to test the energy landscape, where we find local minima corresponding to the so-called jammed states. We study the effect of the ratio of initial friendly to unfriendly connections on the propagation of disease. The steady state can be balanced or a jammed state such that a coexistence occurs between susceptible and infected nodes in the system.

  4. DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans

    Science.gov (United States)

    Gillespie, Leah; Gerstenberg, Kathleen; Ana-Sosa-Batiz, Fernanda; Parsons, Matthew S.; Farrukee, Rubaiyea; Krabbe, Mark; Spann, Kirsten; Brooks, Andrew G.; Londrigan, Sarah L.

    2016-01-01

    ABSTRACT It is well established that glycosaminoglycans (GAGs) function as attachment factors for human metapneumovirus (HMPV), concentrating virions at the cell surface to promote interaction with other receptors for virus entry and infection. There is increasing evidence to suggest that multiple receptors may exhibit the capacity to promote infectious entry of HMPV into host cells; however, definitive identification of specific transmembrane receptors for HMPV attachment and entry is complicated by the widespread expression of cell surface GAGs. pgsA745 Chinese hamster ovary (CHO) cells are deficient in the expression of cell surface GAGs and resistant to HMPV infection. Here, we demonstrate that the expression of the Ca2+-dependent C-type lectin receptor (CLR) DC-SIGN (CD209L) or L-SIGN (CD209L) rendered pgsA745 cells permissive to HMPV infection. Unlike infection of parental CHO cells, HMPV infection of pgsA745 cells expressing DC-SIGN or L-SIGN was dynamin dependent and inhibited by mannan but not by pretreatment with bacterial heparinase. Parental CHO cells expressing DC-SIGN/L-SIGN also showed enhanced susceptibility to dynamin-dependent HMPV infection, confirming that CLRs can promote HMPV infection in the presence or absence of GAGs. Comparison of pgsA745 cells expressing wild-type and endocytosis-defective mutants of DC-SIGN/L-SIGN indicated that the endocytic function of CLRs was not essential but could contribute to HMPV infection of GAG-deficient cells. Together, these studies confirm a role for CLRs as attachment factors and entry receptors for HMPV infection. Moreover, they define an experimental system that can be exploited to identify transmembrane receptors and entry pathways where permissivity to HMPV infection can be rescued following the expression of a single cell surface receptor. IMPORTANCE On the surface of CHO cells, glycosaminoglycans (GAGs) function as the major attachment factor for human metapneumoviruses (HMPV), promoting dynamin

  5. Information structure in Russian Sign Language and Sign Language of the Netherlands

    NARCIS (Netherlands)

    Kimmelman, V.

    2014-01-01

    This dissertation explores Information Structure in two sign languages: Sign Language of the Netherlands and Russian Sign Language. Based on corpus data and elicitation tasks we show how topic and focus are expressed in these languages. In particular, we show that topics can be marked syntactically

  6. On the System of Person-Denoting Signs in Estonian Sign Language: Estonian Name Signs

    Science.gov (United States)

    Paales, Liina

    2010-01-01

    This article discusses Estonian personal name signs. According to study there are four personal name sign categories in Estonian Sign Language: (1) arbitrary name signs; (2) descriptive name signs; (3) initialized-descriptive name signs; (4) loan/borrowed name signs. Mostly there are represented descriptive and borrowed personal name signs among…

  7. The split hand sign

    Directory of Open Access Journals (Sweden)

    Rajesh Benny

    2012-01-01

    Full Text Available Amyotrophic Lateral sclerosis (ALS is a disease characterized by pure motor asymmetric wasting of various muscles with associated upper motor neuron signs. The split hand sign, which is because of dissociated muscle weakness in the hands (thenar muscles disproportionately wasted as compared to the hypothenar muscles is a useful clinical sign for bed side diagnosis of ALS.

  8. Signed languages and globalization

    NARCIS (Netherlands)

    Hiddinga, A.; Crasborn, O.

    2011-01-01

    Deaf people who form part of a Deaf community communicate using a shared sign language. When meeting people from another language community, they can fall back on a flexible and highly context-dependent form of communication called international sign, in which shared elements from their own sign

  9. British Sign Name Customs

    Science.gov (United States)

    Day, Linda; Sutton-Spence, Rachel

    2010-01-01

    Research presented here describes the sign names and the customs of name allocation within the British Deaf community. While some aspects of British Sign Language sign names and British Deaf naming customs differ from those in most Western societies, there are many similarities. There are also similarities with other societies outside the more…

  10. Cholelithiasis: WES Sign

    Directory of Open Access Journals (Sweden)

    Hamid Ehsani-Nia

    2017-01-01

    Full Text Available History of present illness: A 33-year-old female with multiple previous episodes of biliary colic presented to the emergency department with severe right upper quadrant pain that started 30 minutes prior to arrival. She characterized her pain as sharp and pulling and radiating to the back. Upon physical examination, patient was in acute distress with severe tenderness to right upper quadrant palpation. Her abdomen was soft, with no guarding or rebound tenderness. Significant findings: Abdominal ultrasound showed the classic presentation of the Wall-Echo-Shadow (WES sign. The superficial aspect of the gallbladder wall is represented by a hyperechogenic curve. Below this, bile fluid is represented by hypoechogenicity. Underneath the bile fluid is the echo of the dense border created by the collection of gallstones, represented by a hyperechogenic curve. Due to the high density of the gallstones, nothing deeper can be visualized (including other gallstones or the far end of the gallbladder; this is the shadow. Discussion: The WES sign, first described in the early 1980s, is a clear way of identifying cholelithiasis when the condition has progressed to fill the entire lumen of the gallbladder.1 In this case, the lumen of the gallbladder looks hypoechogenic relative to the surrounding tissue, much like an empty gallbladder. This is due to the border of the dense stones opposing the near wall of the gallbladder casting a shadow over everything distal to the stones. These key visualization techniques decrease non-visualization of chronic cholelithiasis.2,3,4 In most cases, WES sign is sufficient to diagnose cholelithiasis. Of note, “porcelain gallbladder” or collapsed duodenum can have the potential produce similar ultrasonographic findings.4,5

  11. EFFECTS OF MATERNAL HIGH FAT DIET AND SEDENTARY LIFESTYLE ON SUSCEPTIBILITY OF ADULT OFFSPRING TO OZONE EXPOSURE IN RATS

    Science.gov (United States)

    Epidemiological and experimental data suggest that obesity exacerbates the health effects of air pollutants such as ozone (O3). Maternal inactivity and calorically rich diets lead to offspring that show signs of obesity. Exacerbated O3 susceptibility of offspring could thus be m...

  12. Water lily sign and serpent sign in pulmonary hydatid cystic disease

    Directory of Open Access Journals (Sweden)

    Ashish Ranjan

    2017-01-01

    Full Text Available The teaching image depicts sections of CT chest showing water lily sign and serpent sign. In the diagnosis of pulmonary hydatid disease, these signs are pathognomonic, these must be corroborated clinically, and early interventions should be done to avoid rupture of cysts leading to complications.

  13. Sign language and autism.

    Science.gov (United States)

    Bonvillian, J D; Nelson, K E; Rhyne, J M

    1981-03-01

    Research findings and issues in teaching sign language to nonspeaking autistic children are reviewed. Data on over 100 children indicate that nearly all autistic children learn receptive and expressive signs, and many learn to combine signs. These children also exhibit marked improvement in adaptive behaviors. Speech skills are acquired by fewer children and may be developed through simultaneous speech and sign training. Possible explanations for these results are given, together with suggestions for future research and data collection. Recommended innovations include exposure to fluent signers and training in discourse and code-switching. Different sign language teaching methods need to be investigated more fully, including emphasis on training sign language within the children's total environment and with greater staff and parental participation.

  14. Iconicity and Sign Lexical Acquisition: A Review.

    Science.gov (United States)

    Ortega, Gerardo

    2017-01-01

    The study of iconicity, defined as the direct relationship between a linguistic form and its referent, has gained momentum in recent years across a wide range of disciplines. In the spoken modality, there is abundant evidence showing that iconicity is a key factor that facilitates language acquisition. However, when we look at sign languages, which excel in the prevalence of iconic structures, there is a more mixed picture, with some studies showing a positive effect and others showing a null or negative effect. In an attempt to reconcile the existing evidence the present review presents a critical overview of the literature on the acquisition of a sign language as first (L1) and second (L2) language and points at some factor that may be the source of disagreement. Regarding sign L1 acquisition, the contradicting findings may relate to iconicity being defined in a very broad sense when a more fine-grained operationalisation might reveal an effect in sign learning. Regarding sign L2 acquisition, evidence shows that there is a clear dissociation in the effect of iconicity in that it facilitates conceptual-semantic aspects of sign learning but hinders the acquisition of the exact phonological form of signs. It will be argued that when we consider the gradient nature of iconicity and that signs consist of a phonological form attached to a meaning we can discern how iconicity impacts sign learning in positive and negative ways.

  15. Characterization of the duplicate L-SIGN and DC-SIGN genes in miiuy croaker and evolutionary analysis of L-SIGN in fishes.

    Science.gov (United States)

    Shu, Chang; Wang, Shanchen; Xu, Tianjun

    2015-05-01

    Dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN/CD209) and liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN/CD299) which are homologues of DC-SIGN are important members in C-type lectin receptors family as key molecules to recognize and eliminate pathogens in the innate immune system. DC-SIGN and L-SIGN have become hot topics in recent studies which both served as cell adhesion and phagocytic pathogen recognition receptors in mammals. However, there have been almost no studies of DC-SIGN and L-SIGN structure and characters in fish, only DC-SIGN in the zebrafish had been studied. In our study, we identified and characterized the full-length miiuy croaker (Miichthys miiuy) DC-SIGN (mmDC-SIGN) and L-SIGN (mmL-SIGN) genes. The sequence analysis results showed that mmDC-SIGN and mmL-SIGN have the same domains with other vertebrates except primates, and share some conserved motifs in CRD among all the vertebrates which play a crucial role in interacting with Ca(2+) and for recognizing mannose-containing motifs. Gene synteny of DC-SIGN and L-SIGN were analyzed for the first time and gene synteny of L-SIGN was conserved among the five fishes. Interestingly, one gene next to L-SIGN from gene synteny had high similarity with L-SIGN gene that was described as L-SIGN-like in fish species. While only one L-SIGN gene existed in other vertebrates, two L-SIGN in fish may be in consequence of the fish-specific genome duplication to adapt the specific environment. The evolutionary analysis showed that the ancestral lineages of L-SIGN gene in fishes experienced purifying selection and the current lineages of L-SIGN gene in fishes underwent positive selection, indicating that the ancestral lineages and current lineages of L-SIGN gene in fishes underwent different evolutionary patterns. Both mmDC-SIGN and mmL-SIGN were expressed in all tested tissues and ubiquitously up-regulated in infected liver, spleen and kidney at different sampling time points

  16. Graphene susceptibility in Holstein model

    Energy Technology Data Exchange (ETDEWEB)

    Mousavi, Hamze, E-mail: hamze.mousavi@gmail.co [Department of Physics, Razi University, Kermanshah (Iran, Islamic Republic of); Nano Science and Nano Technology Research Center, Razi University, Kermanshah (Iran, Islamic Republic of)

    2011-06-15

    We study the effects of the electron-phonon interaction on the temperature dependence of the orbital magnetic susceptibility of monolayer graphene. We use the linear response theory and Green's function formalism within the Holstein Hamiltonian model. The results show that the effects of the electron-phonon interaction on the susceptibility of graphene sheet have different behaviors in two temperature regions. In the low temperature region, susceptibility increases when the electron-phonon coupling strength increases. On the other hand, the susceptibility reduces with increasing the electron-phonon coupling strength in the high temperature region. - Highlights: Effect of electron-phonon interaction on the susceptibility of graphene is studied. Linear response theory and Green's function technique in Holstein model are used. Effect of electron-phonon on susceptibility has different behaviors in two temperature regions.

  17. The Sign Learning Theory

    African Journals Online (AJOL)

    KING OF DAWN

    The Sign Learning Theory. Although a blend of both Gestalt psychology and behaviourism, the sign learning theory is actually a drift from the behaviourist perspective with an attempt to explain certain phenomena commonly seen in behaviour which could not be satisfactorily accounted for by stimulus-response paradigms.

  18. Standardization of Sign Languages

    Science.gov (United States)

    Adam, Robert

    2015-01-01

    Over the years attempts have been made to standardize sign languages. This form of language planning has been tackled by a variety of agents, most notably teachers of Deaf students, social workers, government agencies, and occasionally groups of Deaf people themselves. Their efforts have most often involved the development of sign language books…

  19. Signes et artefacts.

    Directory of Open Access Journals (Sweden)

    Samuel Périgois

    2006-04-01

    the multiplication of ancient signs. Some artefacts refer to the history of the place, with elements inherited from the past and registered in space; some others show a generic idea of the past as the widespread use of urban furniture tends to confirm — traditional lamppost and historical poles are the symbols of an urbanity of appearance. This phenomenon of identity construction aims at producing urbanity, at least physical. This “artefactualisation” brings to a redefinition of the “patrimonialisation”. The current trend to replace “inherited objects” by signs, which point out the pre-existence of these objects, and ancient past simulations refer to the concepts of atmosphere, aesthetics and “simulacra” according to the term used by Jean Baudrillard. The combination of “inherited objects” and ancient artefacts takes part in a setting in scene aiming at registering downtown areas in long time and creating aesthetic “neo-archeo” urbanity specific to small cities.

  20. Phonological Development in Hearing Learners of a Sign Language: The Influence of Phonological Parameters, Sign Complexity, and Iconicity

    Science.gov (United States)

    Ortega, Gerardo; Morgan, Gary

    2015-01-01

    The present study implemented a sign-repetition task at two points in time to hearing adult learners of British Sign Language and explored how each phonological parameter, sign complexity, and iconicity affected sign production over an 11-week (22-hour) instructional period. The results show that training improves articulation accuracy and that…

  1. Signs on bricks of the Semikarakorsk fortress

    Directory of Open Access Journals (Sweden)

    Valeriy S. Flerov,

    2015-12-01

    Full Text Available The article presents a study of bricks with different signs from Semikarakorsk fortress of the Khazar Khaganate on the Lower Don, dating to the late 8th – early 9th centuries. It deals with about one hundred burnt bricks, mainly in fragments, and a fragment of adobe brick, each marked with signs. Signs on bricks from Semikarakorsk fortress are less common than on bricks of Sarkel and Pravoberezhnaya Tsimlyanskaya fortresses, but today, it is the unique collection on the Lower Don that allows tracking how various types of signs are distributed across different sections of the fortress. This approach gives new information on organization of construction business in Eastern Europe in the early Middle Ages, and specifically in Khazar Khaganate. In this regard, the Semikarakorsk collection is comparable to the one from Pliska site. Typological analysis has shown that the Semikarakorsk corpus of signs is less diverse compared to Sarkel and the Mayaki hillfort. Two types of signs are most numerous – bellshaped and trident with a rectangular cup. The former is localized on the northern wall of the fortress, while the latter near the citadel. There is a correlation between sizes of bricks and types of signs. Signs were typically produced by use of tools. Finger drawings are rare (12 %. Signs were applied on the top (during the manufacturing process side of the brick, on raw clay, before baking. The analysis of techniques and styles of drawing showed that similar signs were applied by different people.

  2. Alzheimer skin fibroblasts show increased susceptibility to free radicals.

    Science.gov (United States)

    Tesco, G; Latorraca, S; Piersanti, P; Piacentini, S; Amaducci, L; Sorbi, S

    1992-11-01

    We have studied the response to toxic oxygen metabolites of fibroblasts derived from skin biopsies of 5 patients with familial (FAD) and 4 with sporadic (AD) Alzheimer's disease compared with those derived from 4 normal controls. Fibroblasts were damaged by the generation of oxygen metabolites during the enzymatic oxidation of acetaldehyde by 50 munits of xanthine-oxidase (Xo). To quantify cell damage we measured lactate dehydrogenase (LDH) activity in the culture medium and cell viability in fibroblast cultures. We found a significant increase in LDH activity in the FAD vs. controls and also in the AD vs. controls.

  3. The ATIS sign language corpus

    OpenAIRE

    Bungeroth, Jan; Stein, Daniel; Dreuw, Philippe; Ney, Hermann; Morrissey, Sara; Way, Andy; van Zijl, Lynette

    2008-01-01

    Systems that automatically process sign language rely on appropriate data. We therefore present the ATIS sign language corpus that is based on the domain of air travel information. It is available for five languages, English, German, Irish sign language, German sign language and South African sign language. The corpus can be used for different tasks like automatic statistical translation and automatic sign language recognition and it allows the specific modelling of spatial references in sign...

  4. Phonological Awareness for American Sign Language

    Science.gov (United States)

    Corina, David P.; Hafer, Sarah; Welch, Kearnan

    2014-01-01

    This paper examines the concept of phonological awareness (PA) as it relates to the processing of American Sign Language (ASL). We present data from a recently developed test of PA for ASL and examine whether sign language experience impacts the use of metalinguistic routines necessary for completion of our task. Our data show that deaf signers…

  5. HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN).

    Science.gov (United States)

    Chung, Nancy P Y; Breun, Sabine K J; Bashirova, Arman; Baumann, Joerg G; Martin, Thomas D; Karamchandani, Jaideep M; Rausch, Jason W; Le Grice, Stuart F J; Wu, Li; Carrington, Mary; Kewalramani, Vineet N

    2010-01-15

    In this study, we identify determinants in dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) necessary for human immunodeficiency virus, type 1 (HIV-1), transmission. Although human B cell lines expressing DC-SIGN efficiently capture and transmit HIV-1 to susceptible target cells, cells expressing the related molecule liver/lymph node-specific ICAM-3-grabbing nonintegrin (L-SIGN) do not. To understand the differences between DC-SIGN and L-SIGN that affect HIV-1 interactions, we developed Raji B cell lines expressing different DC-SIGN/L-SIGN chimeras. Testing of the chimeras demonstrated that replacement of the DC-SIGN carbohydrate-recognition domain (CRD) with that of L-SIGN was sufficient to impair virus binding and prevent transmission. Conversely, the ability to bind and transmit HIV-1 was conferred to L-SIGN chimeras containing the DC-SIGN CRD. We identified Trp-258 in the DC-SIGN CRD to be essential for HIV-1 transmission. Although introduction of a K270W mutation at the same position in L-SIGN was insufficient for HIV-1 binding, an L-SIGN mutant molecule with K270W and a C-terminal DC-SIGN CRD subdomain transmitted HIV-1. These data suggest that DC-SIGN structural elements distinct from the oligosaccharide-binding site are required for HIV-1 glycoprotein selectivity.

  6. Signs of Overload

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Healthy Living Nutrition Fitness Sports Oral Health Emotional Wellness Building Resilience Sleep Growing Healthy Healthy Children > Healthy Living > Emotional Wellness > Signs of ...

  7. The Babinski sign.

    Science.gov (United States)

    Morrow, Jasper M; Reilly, Mary M

    2011-10-01

    Joseph Babinski (1857-1932), a French neurologist of Polish descent, was the first person to describe extension of the big toe following stimulation of the sole of the foot on 22 February 1896 (Babinski, 1896). He referred to the sign as 'phénomène des orteils' (toes phenomenon) but it is now usually referred to eponymously as the 'Babinski sign' or descriptively as the extensor plantar response.

  8. Adolf Kussmaul and Kussmaul's sign

    Directory of Open Access Journals (Sweden)

    Navreet Singh

    2015-01-01

    Full Text Available Kussmaul's has provided us with three important signs: Pulses paradoxus, Kussmaul's sign and Kussmaul Breathing. This article discusses Kussmaul's sign, its discovery, first description, pathophyiology and exceptions.

  9. Computational triadic algebras of signs

    Energy Technology Data Exchange (ETDEWEB)

    Zadrozny, W. [T.J. Watson Research Center, Yorktown Heights, NY (United States)

    1996-12-31

    We present a finite model of Peirce`s ten classes of signs. We briefly describe Peirce`s taxonomy of signs; we prove that any finite collection of signs can be extended to a finite algebra of signs in which all interpretants are themselves being interpreted; and we argue that Peirce`s ten classes of signs can be defined using constraints on algebras of signs. The paper opens the possibility of defining multimodal cognitive agents using Peirce`s classes of signs, and is a first step towards building a computational logic of signs based on Peirce`s taxonomies.

  10. These signs here now

    DEFF Research Database (Denmark)

    Raudaskoski, Pirkko Liisa

    1995-01-01

    Hallidays (1984) formulations of systemic-functional linguistics together with Hodge and Kress' (1988) social semiotics share the assumption that signs are not arbitrary: People make choices out of a web of possible constructions or expressions, and those choices can be shown to be motivated......, could be advocated as am improvement to the social semiotic analyses, and whether the Peircean idea of dynamic interpretants could be applied to turn-taking or vica versa. I shall be referring to Kress' paper on the non-arbitrary character of signs (Kress 1993) as a point of departure and comparison....

  11. Tension pneumocephalus: Mount Fuji sign

    Directory of Open Access Journals (Sweden)

    Pulastya Sanyal

    2015-01-01

    Full Text Available A 13-year-old male was operated for a space occupying lesion in the brain. A noncontrast computed tomography scan done in the late postoperative period showed massive subdural air collection causing compression of bilateral frontal lobes with widening of interhemispheric fissure and the frontal lobes acquiring a peak like configuration - causing tension pneumocephalus-"Mount Fuji sign." Tension pneumocephalus occurs when air enters the extradural or intradural spaces in sufficient volume to exert a mass or pressure effect on the brain, leading to brain herniation. Tension pneumocephalus is a surgical emergency, which needs immediate intervention in the form of decompression of the cranial cavity by a burr hole or needle aspiration. The Mount Fuji sign differentiates tension pneumocephalus from pneumocephalus.

  12. Sign Vocabulary Recognition in Students of American Sign Language.

    Science.gov (United States)

    Lupton, Linda; Fristoe, Macalyne

    1992-01-01

    This investigation explored recognition memory for sign language vocabulary in sign language students. Ten beginning and 10 advanced students were asked to judge their familiarity with 50 old and new vocabulary items presented in both written (sign gloss) and signed stimulus modes. (JL)

  13. The Distribution of Signs in New Zealand Sign Language

    Science.gov (United States)

    McKee, David; Kennedy, Graeme

    2006-01-01

    Until now, teachers and learners of NZSL have not had access to information on the most frequently used signs in the Deaf community. This article describes the first study of the distribution of signs in New Zealand Sign Language (NZSL). We hope that it will help teachers of NZSL make decisions about which signs to teach first and suggest…

  14. Visual cortex entrains to sign language.

    Science.gov (United States)

    Brookshire, Geoffrey; Lu, Jenny; Nusbaum, Howard C; Goldin-Meadow, Susan; Casasanto, Daniel

    2017-06-13

    Despite immense variability across languages, people can learn to understand any human language, spoken or signed. What neural mechanisms allow people to comprehend language across sensory modalities? When people listen to speech, electrophysiological oscillations in auditory cortex entrain to slow ([Formula: see text]8 Hz) fluctuations in the acoustic envelope. Entrainment to the speech envelope may reflect mechanisms specialized for auditory perception. Alternatively, flexible entrainment may be a general-purpose cortical mechanism that optimizes sensitivity to rhythmic information regardless of modality. Here, we test these proposals by examining cortical coherence to visual information in sign language. First, we develop a metric to quantify visual change over time. We find quasiperiodic fluctuations in sign language, characterized by lower frequencies than fluctuations in speech. Next, we test for entrainment of neural oscillations to visual change in sign language, using electroencephalography (EEG) in fluent speakers of American Sign Language (ASL) as they watch videos in ASL. We find significant cortical entrainment to visual oscillations in sign language sign is strongest over occipital and parietal cortex, in contrast to speech, where coherence is strongest over the auditory cortex. Nonsigners also show coherence to sign language, but entrainment at frontal sites is reduced relative to fluent signers. These results demonstrate that flexible cortical entrainment to language does not depend on neural processes that are specific to auditory speech perception. Low-frequency oscillatory entrainment may reflect a general cortical mechanism that maximizes sensitivity to informational peaks in time-varying signals.

  15. MRI of the Swallow Tail Sign: A Useful Marker in the Diagnosis of Lewy Body Dementia?

    Science.gov (United States)

    Shams, S; Fällmar, D; Schwarz, S; Wahlund, L-O; van Westen, D; Hansson, O; Larsson, E-M; Haller, S

    2017-09-01

    There are, to date, no MR imaging diagnostic markers for Lewy body dementia. Nigrosome 1, containing dopaminergic cells, in the substantia nigra pars compacta is hyperintense on SWI and has been called the swallow tail sign, disappearing with Parkinson disease. We aimed to study the swallow tail sign and its clinical applicability in Lewy body dementia and hypothesized that the sign would be likewise applicable in Lewy body dementia. This was a retrospective cross-sectional multicenter study including 97 patients (mean age, 65 ± 10 years; 46% women), consisting of the following: controls (n = 21) and those with Lewy body dementia (n = 19), Alzheimer disease (n = 20), frontotemporal lobe dementia (n = 20), and mild cognitive impairment (n = 17). All patients underwent brain MR imaging, with susceptibility-weighted imaging at 1.5T (n = 46) and 3T (n = 51). The swallow tail sign was assessed independently by 2 neuroradiologists. Interrater agreement was moderate (κ = 0.4) between raters. An abnormal swallow tail sign was most common in Lewy body dementia (63%; 95% CI, 41%-85%; P Lewy body dementia with an odds ratio of 9 (95% CI, 3-28; P Lewy body dementia showed a sensitivity of 63%, a specificity of 79%, a negative predictive value of 89%, and an accuracy of 76%; values were higher on 3T compared with 1.5T. The usefulness of the swallow tail sign was rater-dependent with the highest sensitivity equaling 100%. The swallow tail sign has diagnostic potential in Lewy body dementia and may be a complement in the diagnostic work-up of this condition. © 2017 by American Journal of Neuroradiology.

  16. Sign Lowering and Phonetic Reduction in American Sign Language

    OpenAIRE

    Tyrone, Martha E.; Mauk, Claude E.

    2010-01-01

    This study examines sign lowering as a form of phonetic reduction in American Sign Language. Phonetic reduction occurs in the course of normal language production, when instead of producing a carefully articulated form of a word, the language user produces a less clearly articulated form. When signs are produced in context by native signers, they often differ from the citation forms of signs. In some cases, phonetic reduction is manifested as a sign being produced at a lower location than in ...

  17. Signing in Science

    Science.gov (United States)

    Ashby, Rachael

    2013-01-01

    This article describes British Sign Language (BSL) as a viable option for teaching science. BSL is used by a vast number of people in Britain but is seldom taught in schools or included informally alongside lessons. With its new addition of a large scientific glossary, invented to modernise the way science is taught to deaf children, BSL breaks…

  18. Flemish Sign Language Standardisation

    Science.gov (United States)

    Van Herreweghe, Mieke; Vermeerbergen, Myriam

    2009-01-01

    In 1997, the Flemish Deaf community officially rejected standardisation of Flemish Sign Language. It was a bold choice, which at the time was not in line with some of the decisions taken in the neighbouring countries. In this article, we shall discuss the choices the Flemish Deaf community has made in this respect and explore why the Flemish Deaf…

  19. Sign-away Pressures

    Science.gov (United States)

    Rosen, Catherine E.

    1976-01-01

    Why would mental health clients sign release-of-information forms unless they thought a refusal to do so would jeopardize their access to service? The author believes that the practice of not advising clients of their rights to privacy has ethical implications that can compromise the value of the treatment. (Author)

  20. Buffer Zone Sign Template

    Science.gov (United States)

    The certified pesticide applicator is required to post a comparable sign, designating a buffer zone around the soil fumigant application block in order to control exposure risk. It must include the don't walk symbol, product name, and applicator contact.

  1. The Danish Sign Language Dictionary

    DEFF Research Database (Denmark)

    Kristoffersen, Jette Hedegaard; Troelsgård, Thomas

    2010-01-01

    The entries of the The Danish Sign Language Dictionary have four sections:  Entry header: In this section the sign headword is shown as a photo and a gloss. The first occurring location and handshape of the sign are shown as icons.  Video window: By default the base form of the sign headword...... function signs) and mouth movement, cross-references to synonyms etc., information about restricted use, and example sentences. Semantically opaque compounds with the sign are shown below the regular meanings.  Additional information: This section holds cross-references to homonyms and to common frozen...... forms of the sign (only for classifier entries). In addition to this, frequent co-occurrences with the sign are shown in this section. The signs in the The Danish Sign Language Dictionary can be looked up through:  Handshape: Particular handshapes for the active and the passive hand can be specified...

  2. Semiotic Analysis of Brazilian E-Commerce Signs

    Science.gov (United States)

    Guimaraes, Cayley; de Paula, Alice G.; Antunes, Diego R.

    A Semiotic analysis of pictographic signs used in Brazilian e-commerce sites is presented. This study shows a low mapping between the intended function in the system and the desired goal from the user. A better understanding of the Theory of Sign Production and Semiotic Engineering Methods for sign re-design is recommended.

  3. Visual Signs of Ageing

    Directory of Open Access Journals (Sweden)

    Helle Rexbye

    2007-07-01

    Full Text Available Consumer culture has placed the ageing body in a dilemma of representation. Physical appearance has become increasingly important as a symbol of identity, and at the same time society idealizes youth. This study explores visual ageing empirically. By using photographs of older persons (70+ as starting point, it is explored how visual age is assessed and interpreted. It is shown that informants read age in a spread of stages and categories. Main age indicators are biological markers: skin, eyes, and hair colour, but supplemented by vigour, style, and grooming. Furthermore, in-depth interviews indicate that visual age is mainly interpreted into categories and moral regulations rooted in early modernity. Subsequently the question of a postmodern perspective of visual ageing is discussed in this article. The empirical findings in the study question a postmodern fluidity of visual signs – at least when the concern is signs of ageing.

  4. Being and Sign in the "Enneads"

    Science.gov (United States)

    Tomulet, Daniel

    2010-01-01

    The intention of this work is to show that Plotinus' metaphysics, his theory of Intellect, can be interpreted as a philosophy of the sign. The fact that Plotinus describes Intellect, the world of real beings, as a sign or a trace of the One is well-known, and we use this aspect in our work. However, what is even more important from our perspective…

  5. Central structure preservation of the reversal sign

    Energy Technology Data Exchange (ETDEWEB)

    Chen, C.J. [Dept. of Diagnostic Radiology, Chang Gung Memorial Hospital, Taipei (Taiwan)

    1999-12-01

    We report serial changes of central structure preservation of the reversal sign in a case of child abuse. The serial CT images show that the relatively spared attenuation at the basal ganglia, thalami, and posterior fossa develops before the occurrence of transtentorial herniation. This finding makes the theory that central preservation of the reversal sign is due to pressure relief after transtentorial herniation less convincible. (orig.)

  6. Planetary Vital Signs

    Science.gov (United States)

    Kennel, Charles; Briggs, Stephen; Victor, David

    2016-07-01

    The climate is beginning to behave in unusual ways. The global temperature reached unprecedented highs in 2015 and 2016, which led climatologists to predict an enormous El Nino that would cure California's record drought. It did not happen the way they expected. That tells us just how unreliable temperature has become as an indicator of important aspects of climate change. The world needs to go beyond global temperature to a set of planetary vital signs. Politicians should not over focus policy on one indicator. They need to look at the balance of evidence. A coalition of scientists and policy makers should start to develop vital signs at once, since they should be ready at the entry into force of the Paris Agreement in 2020. But vital signs are only the beginning. The world needs to learn how to use the vast knowledge we will be acquiring about climate change and its impacts. Is it not time to use all the tools at hand- observations from space and ground networks; demographic, economic and societal measures; big data statistical techniques; and numerical models-to inform politicians, managers, and the public of the evolving risks of climate change at global, regional, and local scales? Should we not think in advance of an always-on social and information network that provides decision-ready knowledge to those who hold the responsibility to act, wherever they are, at times of their choosing?

  7. Sign language perception research for improving automatic sign language recognition

    Science.gov (United States)

    ten Holt, Gineke A.; Arendsen, Jeroen; de Ridder, Huib; Koenderink-van Doorn, Andrea J.; Reinders, Marcel J. T.; Hendriks, Emile A.

    2009-02-01

    Current automatic sign language recognition (ASLR) seldom uses perceptual knowledge about the recognition of sign language. Using such knowledge can improve ASLR because it can give an indication which elements or phases of a sign are important for its meaning. Also, the current generation of data-driven ASLR methods has shortcomings which may not be solvable without the use of knowledge on human sign language processing. Handling variation in the precise execution of signs is an example of such shortcomings: data-driven methods (which include almost all current methods) have difficulty recognizing signs that deviate too much from the examples that were used to train the method. Insight into human sign processing is needed to solve these problems. Perceptual research on sign language can provide such insights. This paper discusses knowledge derived from a set of sign perception experiments, and the application of such knowledge in ASLR. Among the findings are the facts that not all phases and elements of a sign are equally informative, that defining the 'correct' form for a sign is not trivial, and that statistical ASLR methods do not necessarily arrive at sign representations that resemble those of human beings. Apparently, current ASLR methods are quite different from human observers: their method of learning gives them different sign definitions, they regard each moment and element of a sign as equally important and they employ a single definition of 'correct' for all circumstances. If the object is for an ASLR method to handle natural sign language, then the insights from sign perception research must be integrated into ASLR.

  8. Does walking change the Romberg sign?

    Science.gov (United States)

    Findlay, Gordon F G; Balain, Birender; Trivedi, Jayesh M; Jaffray, David C

    2009-10-01

    The Romberg sign helps demonstrate loss of postural control as a result of severely compromised proprioception. There is still no standard approach to applying the Romberg test in clinical neurology and the criteria for and interpretation of an abnormal result continue to be debated. The value of this sign and its adaptation when walking was evaluated. Detailed clinical examination of 50 consecutive patients of cervical myelopathy was performed prospectively. For the walking Romberg sign, patients were asked to walk 5 m with their eyes open. This was repeated with their eyes closed. Swaying, feeling of instability or inability to complete the walk with eyes closed was interpreted as a positive walking Romberg sign. This test was compared to common clinical signs to evaluate its relevance. Whilst the Hoffman's reflex (79%) was the most prevalent sign seen, the walking Romberg sign was actually present in 74.5% of the cases. The traditional Romberg test was positive in 17 cases and 16 of these had the walking Romberg positive as well. Another 21 patients had a positive walking Romberg test. Though not statistically significant, the mean 30 m walking times were slower in patients with traditional Romberg test than in those with positive walking Romberg test and fastest in those with neither of these tests positive. The combination of either Hoffman's reflex and/or walking Romberg was positive in 96% of patients. The walking Romberg sign is more useful than the traditional Romberg test as it shows evidence of a proprioceptive gait deficit in significantly more patients with cervical myelopathy than is found on conventional neurological examination. The combination of Hoffman's reflex and walking Romberg sign has a potential as useful screening tests to detect clinically significant cervical myelopathy.

  9. TRAFFIC SIGN DETECTION BASED ON BIOLOGICALLY VISUAL MECHANISM

    Directory of Open Access Journals (Sweden)

    X. Hu

    2012-07-01

    Full Text Available TSR (Traffic sign recognition is an important problem in ITS (intelligent traffic system, which is being paid more and more attention for realizing drivers assisting system and unmanned vehicle etc. TSR consists of two steps: detection and recognition, and this paper describe a new traffic sign detection method. The design principle of the traffic sign is comply with the visual attention mechanism of human, so we propose a method using visual attention mechanism to detect traffic sign ,which is reasonable. In our method, the whole scene will firstly be analyzed by visual attention model to acquire the area where traffic signs might be placed. And then, these candidate areas will be analyzed according to the shape characteristics of the traffic sign to detect traffic signs. In traffic sign detection experiments, the result shows the proposed method is effectively and robust than other existing saliency detection method.

  10. Sign language typology: The contribution of rural sign languages

    NARCIS (Netherlands)

    de Vos, C.; Pfau, R.

    2015-01-01

    Since the 1990s, the field of sign language typology has shown that sign languages exhibit typological variation at all relevant levels of linguistic description. These initial typological comparisons were heavily skewed toward the urban sign languages of developed countries, mostly in the Western

  11. Sign language perception research for improving automatic sign language recognition

    NARCIS (Netherlands)

    Ten Holt, G.A.; Arendsen, J.; De Ridder, H.; Van Doorn, A.J.; Reinders, M.J.T.; Hendriks, E.A.

    2009-01-01

    Current automatic sign language recognition (ASLR) seldom uses perceptual knowledge about the recognition of sign language. Using such knowledge can improve ASLR because it can give an indication which elements or phases of a sign are important for its meaning. Also, the current generation of

  12. Sign Lowering and Phonetic Reduction in American Sign Language

    Science.gov (United States)

    Tyrone, Martha E.; Mauk, Claude E.

    2010-01-01

    This study examines sign lowering as a form of phonetic reduction in American Sign Language. Phonetic reduction occurs in the course of normal language production, when instead of producing a carefully articulated form of a word, the language user produces a less clearly articulated form. When signs are produced in context by native signers, they often differ from the citation forms of signs. In some cases, phonetic reduction is manifested as a sign being produced at a lower location than in the citation form. Sign lowering has been documented previously, but this is the first study to examine it in phonetic detail. The data presented here are tokens of the sign WONDER, as produced by six native signers, in two phonetic contexts and at three signing rates, which were captured by optoelectronic motion capture. The results indicate that sign lowering occurred for all signers, according to the factors we manipulated. Sign production was affected by several phonetic factors that also influence speech production, namely, production rate, phonetic context, and position within an utterance. In addition, we have discovered interesting variations in sign production, which could underlie distinctions in signing style, analogous to accent or voice quality in speech. PMID:20607146

  13. Refuting the lipstick sign.

    Science.gov (United States)

    Grassbaugh, Jason A; Bean, Betsey R; Greenhouse, Alyssa R; Yu, Henry H; Arrington, Edward D; Friedman, Richard J; Eichinger, Josef K

    2017-08-01

    Arthroscopic examination of the tendon has been described as the "gold standard" for diagnosis of tendinitis of the long head of the biceps (LHB). An arthroscopic finding of an inflamed and hyperemic LHB within the bicipital groove has been described as the "lipstick sign." Studies evaluating direct visualization in diagnosis of LHB tendinitis are lacking. During a 1-year period, 363 arthroscopic shoulder procedures were performed, with 16 and 39 patients prospectively selected as positive cases and negative controls, respectively. All positive controls had groove tenderness, positive Speed maneuver, and diagnostic ultrasound-guided bicipital injection. Negative controls had none of these findings. Six surgeons reviewed randomized deidentified arthroscopic pictures of enrolled patients The surgeons were asked whether the images demonstrated LHB tendinitis and if the lipstick sign was present. Overall sensitivity and specificity were 49% and 66%, respectively, for detecting LHB tendinitis and 64% and 31%, respectively, for erythema. The nonweighted κ score for interobserver reliability ranged from 0.042 to 0.419 (mean, 0.215 ± 0.116) for tendinitis and from 0.486 to 0.835 (mean, 0.680 ± 0.102) for erythema. The nonweighted κ score for intraobserver reliability ranged from 0.264 to 0.854 (mean, 0.615) for tendinitis and from 0.641 to 0.951 (mean, 0.783) for erythema. The presence of the lipstick sign performed only moderately well in a rigorously designed level III study to evaluate its sensitivity and specificity. There is only fair agreement among participating surgeons in diagnosing LHB tendinitis arthroscopically. Consequently, LHB tendinitis requiring tenodesis remains a clinical diagnosis that should be made before arthroscopic examination. Published by Elsevier Inc.

  14. Signs In Place

    DEFF Research Database (Denmark)

    Hamid, Salmiah Binti Abdul; Jensen, Ole B.; Silva, Victor

    2012-01-01

    Travelling in unfamiliar areas is usually very interesting; however, it can also be stressful. People travel or move around in an urban space according to their needs, and the environment can influence the way people move about from one place to another. If a person gets lost, a map or GPS can...... and geosemiotic studies with regards to the road traffic signs used in urban spaces. The paper ends with a discussion on how people choreograph their movement in their everyday life from two different perspectives: above vs. below...

  15. Signs in Place

    DEFF Research Database (Denmark)

    Hamid, Salmiah Binti Abdul; Jensen, Ole B.; Silva, Victor

    Travelling in unfamiliar areas is usually very interesting, however it can also be stressful. People travel or move around in an urban space according to their needs, and the environment can also influence the way people move about from one place to another. If a person gets lost, a map or GPS can...... and geosemiotic studies with regards to the road traffic signs used in urban spaces. The paper ends with a discussion on how people choreograph their movement in their everyday life from two different perspectives: above vs. below....

  16. Traffic sign detection and analysis

    DEFF Research Database (Denmark)

    Møgelmose, Andreas; Trivedi, Mohan M.; Moeslund, Thomas B.

    2012-01-01

    Traffic sign recognition (TSR) is a research field that has seen much activity in the recent decade. This paper introduces the problem and presents 4 recent papers on traffic sign detection and 4 recent papers on traffic sign classification. It attempts to extract recent trends in the field...

  17. Say It with Sign Language.

    Science.gov (United States)

    Crawford, Wendy

    2001-01-01

    Impressed by Marilyn Daniels' research on the educational benefits of signing for hearing children, a New Jersey early childhood education center trained its staff in sign language as a teaching tool. Students enthusiastically incorporated sign language into their activities as they increased word recognition and vocabulary growth. (MLH)

  18. Issues in Sign Language Lexicography

    DEFF Research Database (Denmark)

    Zwitserlood, Inge; Kristoffersen, Jette Hedegaard; Troelsgård, Thomas

    2013-01-01

    ge lexicography has thus far been a relatively obscure area in the world of lexicography. Therefore, this article will contain background information on signed languages and the communities in which they are used, on the lexicography of sign languages, the situation in the Netherlands as well...... as a review of a sign language dictionary that has recently been published in the Netherlands...

  19. Kinship in Mongolian Sign Language

    Science.gov (United States)

    Geer, Leah

    2011-01-01

    Information and research on Mongolian Sign Language is scant. To date, only one dictionary is available in the United States (Badnaa and Boll 1995), and even that dictionary presents only a subset of the signs employed in Mongolia. The present study describes the kinship system used in Mongolian Sign Language (MSL) based on data elicited from…

  20. Sign language for telemanipulation

    Science.gov (United States)

    Pook, Polly K.; Ballard, Dana H.

    1995-12-01

    Literal teleoperation doesn't work very well. Limited bandwidth, long latencies, non- anthropomorphic mappings all make the effort of teleoperation tedious at best and ineffective at worst. Instead, users of teleoperated and semi-autonomous systems want their robots to `just do it for them,' without sacrificing the operator's intent. Our goal is to maximize human strategic control in teleoperator assisted robotics. In our teleassisted regime, the human operator provides high-level contexts for low-level autonomous robot behaviors. The operator wears an EXOS hand master to communicate via a natural sign language, such as pointing to objects and adopting a grasp preshape. Each sign indicates intention: e.g., reaching or grasping; and, where applicable, a spatial context: e.g., the pointing axis or preshape frame. The robot, a Utah/MIT hand on a Puma arm, acts under local servo control within the proscribed contexts. This paper extends earlier work [Pook & Ballard 1994a] by adding remote visual sensors to the teleassistance repertoire. To view the robot site, the operator wears a virtual research helmet that is coupled to binocular cameras mounted on a second Puma 760. The combined hand-head sensors allows teleassistance to be performed remotely. The example task is to open a door. We also demonstrate the flexibility of the teleassistance model by bootstrapping a `pick and place' task from the door opening task.

  1. INFINITY construction contract signed

    Science.gov (United States)

    2010-01-01

    Key state and community leaders celebrated April 6 with the signing of a construction contract for the state-of-the-art INFINITY Science Center planned near John C. Stennis Space Center in south Mississippi. Gulfport Mayor George Schloegel (l to r), chair of non-profit INFINITY Science Center Inc., was joined for the signing ceremony at the Hancock Bank in Gulfport by Virginia Wagner, sister of late Hancock Bank President Leo Seal Jr.; and Roy Anderson III, president and CEO of Roy Anderson Corp. Seal was the first chair of INFINITY Science Center Inc., which has led in development of the project. Roy Anderson Corp. plans to begin construction on the 72,000-square-foot, $28 million science and education center in May. The Mississippi Department of Transportation (MDOT) also is set to begin construction of a $2 million access road to the new center. The April 6 ceremony was attended by numerous officials, including former Stennis Space Center Directors Jerry Hlass and Roy Estess; Mississippi Senate President Pro Tempore Billy Hewes, R-Gulfport; Mississippi Rep. Diane Peranich, D-Pass Christian; and MDOT Southern District Commissioner Wayne Brown.

  2. Sign rank versus Vapnik-Chervonenkis dimension

    Science.gov (United States)

    Alon, N.; Moran, Sh; Yehudayoff, A.

    2017-12-01

    This work studies the maximum possible sign rank of sign (N × N)-matrices with a given Vapnik-Chervonenkis dimension d. For d=1, this maximum is three. For d=2, this maximum is \\widetilde{\\Theta}(N1/2). For d >2, similar but slightly less accurate statements hold. The lower bounds improve on previous ones by Ben-David et al., and the upper bounds are novel. The lower bounds are obtained by probabilistic constructions, using a theorem of Warren in real algebraic topology. The upper bounds are obtained using a result of Welzl about spanning trees with low stabbing number, and using the moment curve. The upper bound technique is also used to: (i) provide estimates on the number of classes of a given Vapnik-Chervonenkis dimension, and the number of maximum classes of a given Vapnik-Chervonenkis dimension--answering a question of Frankl from 1989, and (ii) design an efficient algorithm that provides an O(N/log(N)) multiplicative approximation for the sign rank. We also observe a general connection between sign rank and spectral gaps which is based on Forster's argument. Consider the adjacency (N × N)-matrix of a Δ-regular graph with a second eigenvalue of absolute value λ and Δ ≤ N/2. We show that the sign rank of the signed version of this matrix is at least Δ/λ. We use this connection to prove the existence of a maximum class C\\subseteq\\{+/- 1\\}^N with Vapnik-Chervonenkis dimension 2 and sign rank \\widetilde{\\Theta}(N1/2). This answers a question of Ben-David et al. regarding the sign rank of large Vapnik-Chervonenkis classes. We also describe limitations of this approach, in the spirit of the Alon-Boppana theorem. We further describe connections to communication complexity, geometry, learning theory, and combinatorics. Bibliography: 69 titles.

  3. Negation switching invariant signed graphs

    Directory of Open Access Journals (Sweden)

    Deepa Sinha

    2014-04-01

    Full Text Available A signed graph (or, $sigraph$ in short is a graph G in which each edge x carries a value $\\sigma(x \\in \\{-, +\\}$ called its sign. Given a sigraph S, the negation $\\eta(S$ of the sigraph S is a sigraph obtained from S by reversing the sign of every edge of S. Two sigraphs $S_{1}$ and $S_{2}$ on the same underlying graph are switching equivalent if it is possible to assign signs `+' (`plus' or `-' (`minus' to vertices of $S_{1}$ such that by reversing the sign of each of its edges that has received opposite signs at its ends, one obtains $S_{2}$. In this paper, we characterize sigraphs which are negation switching invariant and also see for what sigraphs, S and $\\eta (S$ are signed isomorphic.

  4. Translating Signs, Producing Subjects

    Directory of Open Access Journals (Sweden)

    Brett Neilson

    2008-11-01

    Full Text Available This paper moves between two streets: Liverpool Road in the Sydney suburb of Ashfield and Via Sarpi in the Italian city of Milan. What connects these streets is that both have become important sites for businesses in the Chinese diaspora. Moreover, both are streets on which locals have expressed desires for Chinese signs to be translated into the national lingua franca. The paper argues that the cultural politics inherent in this demand for translation cannot be fully understood in the context of national debates about diversity and integration. It is also necessary to consider the emergence of the official Chinese Putonghua as global language, which competes with English but also colonizes dialects and minority languages. In the case of these dual language signs, the space between languages can neither be reduced to a contact zone of minority and majority cultures nor celebrated as a ‘third space’ where the power relations implied by such differences are subverted. At stake is rather a space characterised by what Naoki Sakai calls the schema of co-figuration, which allows the representation of translation as the passage between two equivalents that resemble each other and thus makes possible their determination as conceptually different and comparable. Drawing on arguments about translation and citizenship, the paper critically interrogates the ethos of interchangeability implied by this regime of translation. A closing argument is made for a vision of the common that implies neither civilisational harmony nor the translation of all values into a general equivalent. Primary sources include government reports, internet texts and media stories. These are analyzed using techniques of discourse analysis and interpreted with the help of secondary literature concerning globalisation, language and migration. The disciplinary matrix cuts and mixes between cultural studies, translation studies, citizenship studies, globalization studies and

  5. Making sense of nonsense in British Sign Language (BSL): The contribution of different phonological parameters to sign recognition.

    Science.gov (United States)

    Orfanidou, Eleni; Adam, Robert; McQueen, James M; Morgan, Gary

    2009-04-01

    Do all components of a sign contribute equally to its recognition? In the present study, misperceptions in the sign-spotting task (based on the word-spotting task; Cutler & Norris, 1988) were analyzed to address this question. Three groups of deaf signers of British Sign Language (BSL) with different ages of acquisition (AoA) saw BSL signs combined with nonsense signs, along with combinations of two nonsense signs. They were asked to spot real signs and report what they had spotted. We will present an analysis of false alarms to the nonsense-sign combinations-that is, misperceptions of nonsense signs as real signs (cf. van Ooijen, 1996). Participants modified the movement and handshape parameters more than the location parameter. Within this pattern, however, there were differences as a function of AoA. These results show that the theoretical distinctions between form-based parameters in sign-language models have consequences for online processing. Vowels and consonants have different roles in speech recognition; similarly, it appears that movement, handshape, and location parameters contribute differentially to sign recognition.

  6. Rigler’s sign and the football sign

    Directory of Open Access Journals (Sweden)

    Sheetal Daya

    2012-12-01

    Full Text Available Rigler’s sign was first described in 1941 by L G Rigler as a new radiological sign for recognising free air in the peritoneal cavity on supine radiograph. The presence of pneumoperitoneum allows free intraperitoneal air to be contrasted with intraluminal gas, accentuating the wall of gas-containing viscera. It is observed in infants and very ill patients where only limited radiographs of the abdomen are possible. The football sign was first described by R E Miller in the 1960s. Seen on supine abdominal radiographs, this describes an oval radiolucency resembling an American football. It is important for the radiologist to recognise the supporting signs of pneumoperitoneum, such as Rigler’s sign and the football sign, on supine abdominal radiographs, especially in neonates and infants, where erect chest/abdominal radiographs are not always possible.

  7. Limited Susceptibility of Cynomolgus Monkeys (Macaca fascicularis) to Leprosy after Experimental Administration of Mycobacterium leprae

    Science.gov (United States)

    Walsh, Gerald P.; Dela Cruz, Eduardo C.; Abalos, Rodolfo M.; Tan, Esterlina V.; Fajardo, Tranquilino T.; Villahermosa, Laarni G.; Cellona, Roland V.; Balagon, Maria V.; White, Valerie A.; Saunderson, Paul R.; Walsh, Douglas S.

    2012-01-01

    Cynomolgus monkeys are a useful model for human tuberculosis, but susceptibility to M. leprae is unknown. A cynomolgus model of leprosy could increase understanding of pathogenesis—importantly, neuritis and nerve-damaging reactions. We administered viable Mycobacterium leprae to 24 cynomolgus monkeys by three routes, with a median follow-up period of 6 years (range = 1–19 years) involving biopsies, nasal smears, antiphenolic glycolipid-1 (PGL-1) antibody serology, and lepromin skin testing. Most developed evanescent papules at intradermal M. leprae inoculation sites that, on biopsy, showed a robust cellular immune response akin to a lepromin skin test reaction; many produced PGL-1 antibodies. At necropsy, four monkeys, without cutaneous or gross neurological signs of leprosy but with elevated PGL-1 antibodies, including three with nasal smears (+) for acid fast bacilli (AFB), showed histological features, including AFB, suggestive of leprosy at several sites. Overall, however, cynomolgus monkeys seem minimally susceptible to leprosy after experimental M. leprae administration. PMID:22855766

  8. An Efficient Framework for Road Sign Detection and Recognition

    Directory of Open Access Journals (Sweden)

    Duanling Li

    2014-02-01

    Full Text Available Road sign detection and recognition is a significant and challenging issue not only for assisting drivers but also navigating mobile robots. In this paper, we propose a novel and fast approach for the automatic detection and recognition of road signs. First, we use Hue Saturation Intensity (HSI color space to segment the road signs color. And then we locate the road signs based on the geometry symmetry, as almost all the shapes of road sign shapes are symmetrical such circle, rectangle, triangle and octagon. The proposed shape feature is further applied to classify the shape initially. Finally, the road signs are exactly recognized by support vector machine (SVM classifiers. We test our proposed method on real road images and the experimental results show that it can detect and recognize road signs rapidly and accurately.

  9. LSE-Sign: A lexical database for Spanish Sign Language.

    Science.gov (United States)

    Gutierrez-Sigut, Eva; Costello, Brendan; Baus, Cristina; Carreiras, Manuel

    2016-03-01

    The LSE-Sign database is a free online tool for selecting Spanish Sign Language stimulus materials to be used in experiments. It contains 2,400 individual signs taken from a recent standardized LSE dictionary, and a further 2,700 related nonsigns. Each entry is coded for a wide range of grammatical, phonological, and articulatory information, including handshape, location, movement, and non-manual elements. The database is accessible via a graphically based search facility which is highly flexible both in terms of the search options available and the way the results are displayed. LSE-Sign is available at the following website: http://www.bcbl.eu/databases/lse/.

  10. The clothes maketh the sign.

    Science.gov (United States)

    Buckley, Bryan; Chan, Victoria O; Mitchell, David P; McDermott, Shaunagh; Eisenberg, Ron L; Heffernan, Eric J; Ridge, Carole A

    2016-08-01

    Pattern recognition is a key tool that enables radiologists to evoke certain diagnoses based on a radiologic appearance. In Shakespeare's Hamlet, Polonius tells his son Laertes to dress well because "apparel oft proclaims the man"; this phrase is now expressed in modern parlance as "the clothes maketh the man". Similarly in radiology, appearances are everything, and in the case of radiologic signs, occasionally "the clothes maketh the sign". The radiologic signs described in this pictorial review resemble items of clothing, fabric types, headwear, or accessories and are found in the musculoskeletal, pulmonary, gastrointestinal, and genitourinary systems. These "clothing signs" serve as a useful visual trigger to help radiologists to identify particular disease entities. • Pattern recognition enables radiologists to evoke a diagnosis based on radiologic appearance. • The radiologic signs described in this review resemble clothing, fabric, or accessories. • These "clothing signs" serve as visual triggers that evoke particular disease entities.

  11. Sign Languages of the World

    DEFF Research Database (Denmark)

    This handbook provides information on some 38 sign languages, including basic facts about each of the languages, structural aspects, history and culture of the Deaf communities, and history of research. The papers are all original, and each has been specifically written for the volume by an expert...... or team of experts in the particular sign language, at the invitation of the editors. Thirty-eight different deaf sign languages and alternate sign languages from every continent are represented, and over seventy international deaf and hearing scholars have contributed to the volume....

  12. DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans

    DEFF Research Database (Denmark)

    Olesen, R; Wejse, C; Velez, D R

    2007-01-01

    We investigated the role of DC-SIGN (CD209), long pentraxin 3 (PTX3) and vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) in susceptibility to pulmonary tuberculosis (TB) in 321 TB cases and 347 healthy controls from Guinea-Bissau. Five additional, functionally relevant SNPs...... in a nonadditive model with disease risk when analyzed in combination with ethnicity (P=0.03 for DC-SIGN and P=0.003 for VDR). In addition, PTX3 haplotype frequencies significantly differed in cases compared to controls and a protective effect was found in association with a specific haplotype (OR 0.78, 95% CI 0.......63-0.98). Our findings support previous data showing that VDR SNPs modulate the risk for TB in West Africans and suggest that variation within DC-SIGN and PTX3 also affect the disease outcome. Udgivelsesdato: 2007-Sep...

  13. Automatic sign language recognition inspired by human sign perception

    NARCIS (Netherlands)

    Ten Holt, G.A.

    2010-01-01

    Automatic sign language recognition is a relatively new field of research (since ca. 1990). Its objectives are to automatically analyze sign language utterances. There are several issues within the research area that merit investigation: how to capture the utterances (cameras, magnetic sensors,

  14. Inuit Sign Language: a contribution to sign language typology

    NARCIS (Netherlands)

    Schuit, J.; Baker, A.; Pfau, R.

    2011-01-01

    Sign language typology is a fairly new research field and typological classifications have yet to be established. For spoken languages, these classifications are generally based on typological parameters; it would thus be desirable to establish these for sign languages. In this paper, different

  15. Planning Sign Languages: Promoting Hearing Hegemony? Conceptualizing Sign Language Standardization

    Science.gov (United States)

    Eichmann, Hanna

    2009-01-01

    In light of the absence of a codified standard variety in British Sign Language and German Sign Language ("Deutsche Gebardensprache") there have been repeated calls for the standardization of both languages primarily from outside the Deaf community. The paper is based on a recent grounded theory study which explored perspectives on sign…

  16. Pseudo--Normals for Signed Distance Computation

    DEFF Research Database (Denmark)

    Aanæs, Henrik; Bærentzen, Jakob Andreas

    2003-01-01

    undertake showing that the angle weighted pseudo--normal has an important property, namely that it allows us to discriminate between points that are inside and points that are outside the mesh. This result is used for proposing a simple and efficient algorithm for computing the signed distance field from...

  17. Capturing a Movement: Sign Language Preservation

    Science.gov (United States)

    Burch, Susan

    2004-01-01

    This article examines the various ways in which deaf people have protected and promoted sign language during the early decades of the twentieth century. Arguing that deaf people played an active role in their own history, the author shows how members of the community--through formal and informal collaboration--ultimately defeated strict oralist…

  18. Aristote, Saussure et la convention du signe

    Directory of Open Access Journals (Sweden)

    Vincenzo PARDO

    2011-01-01

    Full Text Available We propose a new critical reading of Aristotle and Saussure, a new point of view on the conventionalist thesis, the composition of acoustic and articulatory sign, and the limits of arbitrariness of the sign. We will show that the more congenial translation of κατà συνθηκην [kata suntheken], expression of a primitive thesis of the "conventional arbitrariness" and, anticipated in the De Interpretatione of Aristotle, rather than “for convention” we believe, it would be “for composition".

  19. Central dot sign in entities other than Caroli disease

    Energy Technology Data Exchange (ETDEWEB)

    Ahmadi, T.; Itai, Yuji [Tsukuba Univ., Ibaraki (Japan). Inst. of Clinical Medicine; Minami, Manabu

    1997-11-01

    The purpose of this study was to describe central dot sign (tiny dots with strong contrast enhancement of the portal vein within dilated hepatic bile ducts on computed tomography) in entities other than Caroli disease, especially in peribiliary cysts with or without autosomal-dominant polycystic kidney disease. Computed tomography in 74 cases of peribiliary cysts and 134 cases of other liver diseases and states possibly showing central dot sign were retrospectively reviewed to examine the central dot sign. In three cases of peribiliary cysts, some part of the liver showed strongly enhanced portal radicles surrounded completely or partially by low-attenuation, enlarged peribiliary cysts, presenting ``central dot sign`` on contrast-enhanced computed tomography. We suggest that in addition to Caroli disease, some other entities and diseases of the liver may demonstrate central dot sign and this sign should not be considered a specific finding of Caroli disease. (author)

  20. Africa: signs of hope?

    Directory of Open Access Journals (Sweden)

    J.F. Kirsten

    2008-07-01

    Full Text Available The dawning of the 21st century generally brought new hope to African leaders and countless thousands of ordinary citizens of many countries on the continent. The first signs of a new turn of events shone through by the end of the last decade of the previous century. This was manifested by economic growth rates that started to pick up in a number of African states, by pro-democracy movements which in country after country succeeded in replacing authoritarian regimes, and by the winding down and termination of some of Africa’s most devastating wars. The results of this analysis confirm the above-mentioned positive political, economic and conflict trends in Africa. It is clearly a significant turn of events given the well-known political and economic predicament with which Africa is struggling. When this negative legacy and Cold War background of Africa is considered, the importance of present developments is clear to see. The identified heightened sense of purpose among the leaders and peoples of Africa and the changed mood and need among Africans to take charge of their own future that found expression in the New Partnership for Africa’s Development (NEPAD are indeed significant and bode well for the future of the continent. A word of warning here is, however, necessary. Our conduct with Africa must be very cautious and we must guard against over-optimism and the exaggerated belief that Africa is now on a trajectory of sustained development and peace. We cannot generalise about Africa – for that the continent is just too big and diverse from a geographical, cultural, economic and political point of view.

  1. [Information technology in learning sign language].

    Science.gov (United States)

    Hernández, Cesar; Pulido, Jose L; Arias, Jorge E

    2015-01-01

    To develop a technological tool that improves the initial learning of sign language in hearing impaired children. The development of this research was conducted in three phases: the lifting of requirements, design and development of the proposed device, and validation and evaluation device. Through the use of information technology and with the advice of special education professionals, we were able to develop an electronic device that facilitates the learning of sign language in deaf children. This is formed mainly by a graphic touch screen, a voice synthesizer, and a voice recognition system. Validation was performed with the deaf children in the Filadelfia School of the city of Bogotá. A learning methodology was established that improves learning times through a small, portable, lightweight, and educational technological prototype. Tests showed the effectiveness of this prototype, achieving a 32 % reduction in the initial learning time for sign language in deaf children.

  2. Signed language working memory capacity of signed language interpreters and deaf signers.

    Science.gov (United States)

    Wang, Jihong; Napier, Jemina

    2013-04-01

    This study investigated the effects of hearing status and age of signed language acquisition on signed language working memory capacity. Professional Auslan (Australian sign language)/English interpreters (hearing native signers and hearing nonnative signers) and deaf Auslan signers (deaf native signers and deaf nonnative signers) completed an Auslan working memory (WM) span task. The results revealed that the hearing signers (i.e., the professional interpreters) significantly outperformed the deaf signers on the Auslan WM span task. However, the results showed no significant differences between the native signers and the nonnative signers in their Auslan working memory capacity. Furthermore, there was no significant interaction between hearing status and age of signed language acquisition. Additionally, the study found no significant differences between the deaf native signers (adults) and the deaf nonnative signers (adults) in their Auslan working memory capacity. The findings are discussed in relation to the participants' memory strategies and their early language experience. The findings present challenges for WM theories.

  3. Learning to Detect Traffic Signs

    DEFF Research Database (Denmark)

    Møgelmose, Andreas; Trivedi, Mohan M.; Moeslund, Thomas B.

    2012-01-01

    This study compares the performance of sign detection based on synthetic training data to the performance of detection based on real-world training images. Viola-Jones detectors are created for 4 different traffic signs with both synthetic and real data, and varying numbers of training samples...

  4. Sign Facilitation in Word Recognition.

    Science.gov (United States)

    Wauters, Loes N.; Knoors, Harry E. T.; Vervloed, Mathijs P. J.; Aarnoutse, Cor A. J.

    2001-01-01

    This study examined whether use of sign language would facilitate reading word recognition by 16 deaf children (6- to 1 years-old) in the Netherlands. Results indicated that if words were learned through speech, accompanied by the relevant sign, accuracy of word recognition was greater than if words were learned solely through speech. (Contains…

  5. Concise Lexicon for Sign Linguistics

    NARCIS (Netherlands)

    dr. Jan Nijen Twilhaar; Dr. Beppie van den Bogaerde

    2016-01-01

    This extensive, well-researched and clearly formatted lexicon of a wide variety of linguistic terms is a long overdue. It is an extremely welcome addition to the bookshelves of sign language teachers, interpreters, linguists, learners and other sign language users, and of course of the Deaf

  6. Activation Cascading in Sign Production

    Science.gov (United States)

    Navarrete, Eduardo; Peressotti, Francesca; Lerose, Luigi; Miozzo, Michele

    2017-01-01

    In this study, we investigated how activation unfolds in sign production by examining whether signs that are not produced have their representations activated by semantics (cascading of activation). Deaf signers were tested with a picture-picture interference task. Participants were presented with pairs of overlapping pictures and named the green…

  7. Syntactic priming in American Sign Language.

    Science.gov (United States)

    Hall, Matthew L; Ferreira, Victor S; Mayberry, Rachel I

    2015-01-01

    Psycholinguistic studies of sign language processing provide valuable opportunities to assess whether language phenomena, which are primarily studied in spoken language, are fundamentally shaped by peripheral biology. For example, we know that when given a choice between two syntactically permissible ways to express the same proposition, speakers tend to choose structures that were recently used, a phenomenon known as syntactic priming. Here, we report two experiments testing syntactic priming of a noun phrase construction in American Sign Language (ASL). Experiment 1 shows that second language (L2) signers with normal hearing exhibit syntactic priming in ASL and that priming is stronger when the head noun is repeated between prime and target (the lexical boost effect). Experiment 2 shows that syntactic priming is equally strong among deaf native L1 signers, deaf late L1 learners, and hearing L2 signers. Experiment 2 also tested for, but did not find evidence of, phonological or semantic boosts to syntactic priming in ASL. These results show that despite the profound differences between spoken and signed languages in terms of how they are produced and perceived, the psychological representation of sentence structure (as assessed by syntactic priming) operates similarly in sign and speech.

  8. Syntactic priming in American Sign Language.

    Directory of Open Access Journals (Sweden)

    Matthew L Hall

    Full Text Available Psycholinguistic studies of sign language processing provide valuable opportunities to assess whether language phenomena, which are primarily studied in spoken language, are fundamentally shaped by peripheral biology. For example, we know that when given a choice between two syntactically permissible ways to express the same proposition, speakers tend to choose structures that were recently used, a phenomenon known as syntactic priming. Here, we report two experiments testing syntactic priming of a noun phrase construction in American Sign Language (ASL. Experiment 1 shows that second language (L2 signers with normal hearing exhibit syntactic priming in ASL and that priming is stronger when the head noun is repeated between prime and target (the lexical boost effect. Experiment 2 shows that syntactic priming is equally strong among deaf native L1 signers, deaf late L1 learners, and hearing L2 signers. Experiment 2 also tested for, but did not find evidence of, phonological or semantic boosts to syntactic priming in ASL. These results show that despite the profound differences between spoken and signed languages in terms of how they are produced and perceived, the psychological representation of sentence structure (as assessed by syntactic priming operates similarly in sign and speech.

  9. Syntactic Priming in American Sign Language

    Science.gov (United States)

    Hall, Matthew L.; Ferreira, Victor S.; Mayberry, Rachel I.

    2015-01-01

    Psycholinguistic studies of sign language processing provide valuable opportunities to assess whether language phenomena, which are primarily studied in spoken language, are fundamentally shaped by peripheral biology. For example, we know that when given a choice between two syntactically permissible ways to express the same proposition, speakers tend to choose structures that were recently used, a phenomenon known as syntactic priming. Here, we report two experiments testing syntactic priming of a noun phrase construction in American Sign Language (ASL). Experiment 1 shows that second language (L2) signers with normal hearing exhibit syntactic priming in ASL and that priming is stronger when the head noun is repeated between prime and target (the lexical boost effect). Experiment 2 shows that syntactic priming is equally strong among deaf native L1 signers, deaf late L1 learners, and hearing L2 signers. Experiment 2 also tested for, but did not find evidence of, phonological or semantic boosts to syntactic priming in ASL. These results show that despite the profound differences between spoken and signed languages in terms of how they are produced and perceived, the psychological representation of sentence structure (as assessed by syntactic priming) operates similarly in sign and speech. PMID:25786230

  10. Susceptibility to malignant hyperthermia

    NARCIS (Netherlands)

    Snoeck, Marcus Matheus Johannes

    2004-01-01

    In this thesis the author studied the diagnostic procedures for susceptibility to malignant hyperthermia (MH), with special emphasis upon refining the biological diagnostic test and improving protocols and guidelines for investigation of MH susceptibility. MH is a pharmacogenetic disease of skeletal

  11. Sign Inference for Dynamic Signed Networks via Dictionary Learning

    Directory of Open Access Journals (Sweden)

    Yi Cen

    2013-01-01

    Full Text Available Mobile online social network (mOSN is a burgeoning research area. However, most existing works referring to mOSNs deal with static network structures and simply encode whether relationships among entities exist or not. In contrast, relationships in signed mOSNs can be positive or negative and may be changed with time and locations. Applying certain global characteristics of social balance, in this paper, we aim to infer the unknown relationships in dynamic signed mOSNs and formulate this sign inference problem as a low-rank matrix estimation problem. Specifically, motivated by the Singular Value Thresholding (SVT algorithm, a compact dictionary is selected from the observed dataset. Based on this compact dictionary, the relationships in the dynamic signed mOSNs are estimated via solving the formulated problem. Furthermore, the estimation accuracy is improved by employing a dictionary self-updating mechanism.

  12. A New Ultrasound Biomicroscopic Sign seen after Deep Sclerectomy (Dolphin Head Sign).

    Science.gov (United States)

    Abdelrahman, Ahmed M; Cheweikh, Hala M El; El-Fayoumi, Dina Ms; Allam, Riham Shm

    2016-01-01

    To describe a new ultrasound biomicroscopic (UBM) sign seen in patients who underwent deep sclerectomy (DS) as a surgical procedure for the management of uncontrolled primary open-angle glaucoma (POAG). The presence of this sign in ultrasound biomicroscopy is suggested to be an indicator of successful surgery. We would like to name this sign as the "dolphin head sign." Prospective interventional study. Twenty-eight eyes of 17 patients with POAG underwent DS with intraoperative mitomycin C (MMC) 0.3% applied for 2 minutes under the superficial scleral flap. Patients were followed up for a minimum of 6 months. Ultrasound biomicroscopy was done at the third postoperative month to evaluate the surgical area in both successful and failed cases. The study included 28 eyes of 17 patients. The mean age of the study group was 42.90 ± 14.37 years (20-64 years). The study included 10 females and 7 males. The mean preoperative intraocular pressure (IOP) was 24.57 ± 6.37 mm Hg (20-38 mm Hg). The mean best corrected visual acuity (BCVA) was 0.57 ± 0.3 (0.05-1.00). Complete success has been achieved in 21 eyes (75%) during the follow-up period, with a mean IOP of 12.00 ± 3.86 mm Hg (6-20 mm Hg). The dolphin head sign was demonstrated only in successful cases, whereas the unsuccessful cases failed to show the typical sign. The presence of a "dolphin head" configuration in UBM images could be taken as an indicator of successful DS. How to cite this article: Abdelrahman AM, El Cheweikh HM, El-Fayoumi DMS, Allam RSHM. A New Ultrasound Biomicroscopic Sign seen after Deep Sclerectomy (Dolphin Head Sign). J Curr Glaucoma Pract 2016;10(2):56-59.

  13. Impacts of Visual Sonority and Handshape Markedness on Second Language Learning of American Sign Language

    Science.gov (United States)

    Newman, Sharlene D.

    2016-01-01

    The roles of visual sonority and handshape markedness in sign language acquisition and production were investigated. In Experiment 1, learners were taught sign-nonobject correspondences that varied in sign movement sonority and handshape markedness. Results from a sign-picture matching task revealed that high sonority signs were more accurately matched, especially when the sign contained a marked handshape. In Experiment 2, learners produced these familiar signs in addition to novel signs, which differed based on sonority and markedness. Results from a key-release reaction time reproduction task showed that learners tended to produce high sonority signs much more quickly than low sonority signs, especially when the sign contained an unmarked handshape. This effect was only present in familiar signs. Sign production accuracy rates revealed that high sonority signs were more accurate than low sonority signs. Similarly, signs with unmarked handshapes were produced more accurately than those with marked handshapes. Together, results from Experiments 1 and 2 suggested that signs that contain high sonority movements are more easily processed, both perceptually and productively, and handshape markedness plays a differential role in perception and production. PMID:26644551

  14. Comparative study of genetic influence on the susceptibility of exotic ...

    African Journals Online (AJOL)

    Comparative study of genetic influence on the susceptibility of exotic cockerels, pullets and broilers to infectious bursal disease virus. ... The clinical signs were severe depression, diarrhoea, anorexia, prostration followed by death. Mortality was 92%, 78% and 6% for cockerels, pullets and broilers, respectively, within 3 days ...

  15. Where the signs prevail

    Directory of Open Access Journals (Sweden)

    Dardo Scavino

    2016-03-01

    Full Text Available We propose to show in our paper that through his semiotic theory, Barthes developed a theory of subjectivity and society continued with the anti-utilitarian tradition of the Collège de Sociologie where George Bataille, Carl Einstein or Michel Leiris had favored the mythical and ritual dimension of collective life.

  16. Cytokines and mother sporocysts in susceptible and resistant Bulinus truncatus snails infected with Schistosoma haematobium.

    Science.gov (United States)

    El-Din, Abdel Hakim Saad; Gawish, Fathiya Ali; Abu El Einin, Hanaa Mohamed; Mansour, Shereen Mahfouz

    2014-08-01

    The presence of immunoreactive interleukin (IL-2), interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) in addition to the citation of mother sporscytes in cephalopodal musculature in the susceptible and resistance Bulinus truncatus the specific intermediate host for the trematode Schistosoma haematobium were investigated,. Using ELISA tests, Results indicated that the concentration of IL-2-like activity in the susceptible and resistant snails decreased significantly after infection then persisted at low levels until the 4th week post exposure (WPE) in susceptible snails, while in resistant snails elevated during the second WPE, and returned to initial level at 3 and 4 WPE. Susceptible snails had low detectable levels of TNF-α and INF-γ like-activity after infection. However, the resistant snails had significant low levels of TNF-α and INF-γ like-activity from 3 WPE until the 4th WPE without any sign of normalization. Histological sections in the head- foot region of susceptible and resistance B. truncatus infected with S. haematobium, mother sporocysts exists from 1 to 7(day post exposure) DPE, in the susceptible snail the mother sporocysts were found as single, multiple and mature types. No mother sporocysts were appear in the lip and mantle of the snail on 2, 5, 7 DPE and on 1-3, 6 DPE respectively. In the resistant snails few mother sporocysts were found in the lip, mantle and tentacles. The results showed that schistosome-resistant Bulinus can be an alternative strategy for the control of schistosomiasis.

  17. Aging changes in vital signs

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/004019.htm Aging changes in vital signs To use the sharing ... Normal body temperature does not change much with aging. But as you get older, it becomes harder ...

  18. Wavelets for sign language translation

    Science.gov (United States)

    Wilson, Beth J.; Anspach, Gretel

    1993-10-01

    Wavelet techniques are applied to help extract the relevant parameters of sign language from video images of a person communicating in American Sign Language or Signed English. The compression and edge detection features of two-dimensional wavelet analysis are exploited to enhance the algorithms under development to classify the hand motion, hand location with respect to the body, and handshape. These three parameters have different processing requirements and complexity issues. The results are described for applying various quadrature mirror filter designs to a filterbank implementation of the desired wavelet transform. The overall project is to develop a system that will translate sign language to English to facilitate communication between deaf and hearing people.

  19. Quantifiers in Russian Sign Language

    NARCIS (Netherlands)

    Kimmelman, V.; Paperno, D.; Keenan, E.L.

    2017-01-01

    After presenting some basic genetic, historical and typological information about Russian Sign Language, this chapter outlines the quantification patterns it expresses. It illustrates various semantic types of quantifiers, such as generalized existential, generalized universal, proportional,

  20. Etiology and antibiotic susceptibility pattern of community-acquired ...

    African Journals Online (AJOL)

    Streptomycin showed the highest susceptibility to bacteria isolates while the least susceptibility was observed with augmentin. Rational use of antibiotics with regular antibiotics susceptibility surveillance studies is recommended to maintain high antibiotic therapeutic profile. Keywords: Community-acquired urinary tract ...

  1. Susceptibility Status of Anopheles gambiae s.l. (Diptera: Culicidae ...

    African Journals Online (AJOL)

    komla

    susceptible 'Kisumu' strain, both Korle-Bu and Airport populations were highly resistant to DDT and gave resistance levels which were over nine-fold for permethrin and over 2.5-fold for deltamethrin. Both wild and susceptible populations showed full susceptibility to malathion. The S and M forms of A. gambiae s.s. were ...

  2. Susceptibility status of Anopheles gambiae s.l. (Diptera: Culicidae ...

    African Journals Online (AJOL)

    susceptible 'Kisumu' strain, both Korle-Bu and Airport populations were highly resistant to DDT and gave resistance levels which were over nine-fold for permethrin and over 2.5-fold for deltamethrin. Both wild and susceptible populations showed full susceptibility to malathion. The S and M forms of A. gambiae s.s. were ...

  3. Quark number density and susceptibility calculation under one loop ...

    Indian Academy of Sciences (India)

    S Somorendro Singh

    2017-05-30

    May 30, 2017 ... Abstract. We calculate quark number density and susceptibility under one-loop correction in the mean- field potential. The calculation shows continuous increase in the number density and susceptibility up to the temperature T = 0.4 GeV. Then the values of number density and susceptibility approach the ...

  4. [Antimicrobial susceptibility cumulative reports].

    Science.gov (United States)

    Canut-Blasco, Andrés; Calvo, Jorge; Rodríguez-Díaz, Juan Carlos; Martínez-Martínez, Luis

    2016-10-01

    Cumulative reports on antimicrobial susceptibility tests data are important for selecting empirical treatments, as an educational tool in programs on antimicrobial use, and for establishing breakpoints defining clinical categories. These reports should be based on data validated by clinical microbiologists using diagnostic samples (not surveillance samples). In order to avoid a bias derived from including several isolates obtained from the same patient, it is recommended that, for a defined period, only the first isolate is counted. A minimal number of isolates per species should be presented: a figure of >=30 isolates is statistically acceptable. The report is usually presented in a table format where, for each cell, information on clinically relevant microorganisms-antimicrobial agents is presented. Depending on particular needs, multiple tables showing data related to patients, samples, services or special pathogens can be prepared. Copyright © 2015 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  5. 23 CFR 750.710 - Landmark signs.

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Landmark signs. 750.710 Section 750.710 Highways FEDERAL... Outdoor Advertising Control § 750.710 Landmark signs. (a) 23 U.S.C. 131(c) permits the existence of signs... Secretary, to be landmark signs, including signs on farm structures or natural surfaces, of historic or...

  6. Signs of learning

    DEFF Research Database (Denmark)

    Brodersen, Peter

    and Science. The main hypothesis claims correlation between the following four phases and actions: a) teacher planning and b) the teacher's presentation of the topic and c) students' exercises / their own collaboration and the teacher’s scaffolding, and d) student performance in terms of presentations...... or tests. The preliminary results show some tendencies which are decisive in relation to increase or decrease students' attention, participation and self-reliance. On teacher planning (a): An analysis of the technical difficulties that non-confident students might face carried out proactively. Re...

  7. Show-Bix &

    DEFF Research Database (Denmark)

    2014-01-01

    The anti-reenactment 'Show-Bix &' consists of 5 dias projectors, a dial phone, quintophonic sound, and interactive elements. A responsive interface will enable the Dias projectors to show copies of original dias slides from the Show-Bix piece ”March på Stedet”, 265 images in total. The copies...... are made from digital scans of the original dias slides located in the collection of the Museum of Contemporary Art in Roskilde. In front of the audience entering the space and placed on it’s own stand, is an original 60s style telephone with turning dial. Action begins when the audience lift the phone...... and dial a number. Any number will make the Dias change. All numbers are also assigned to specific sound documents: clips form rare interviews and the complete sound-re-enactment of the Show-Bix piece ‘Omringning’ (‘Surrounding’) in five channels (a quintophonie). This was originally produced...

  8. Show and Tell

    DEFF Research Database (Denmark)

    2013-01-01

    Fredag d. 1 november blev Kunsthal Charlottenborg indtaget af performanceprogrammet Show & Tell med et bredspektret program af danske og internationale kunstnere indenfor performance-, lyd- og installationskunst. Programmet præsenterer værker, der undersøger kroppens stadig mere symbiotiske forhold...... og studienævnet på Performance-design. Show & Tell - Performance program: kl. 16.30-19 Adresse: Kunsthal Charlottenborg, Nyhavn 2, 1051 København K...

  9. The expressions of spatial relations during interaction in american sign language, croatian sign language, and turkish sign language

    OpenAIRE

    Arık, Engin

    2012-01-01

    Signers use their body and the space in front of them iconically. Does iconicity lead to the same mapping strategies in construing space during interaction across sign languages? The present study addressed this question by conducting an experimental study on basic static and motion event descriptions during interaction (describer input and addressee re-signing/retelling) in American Sign Language, Croatian Sign Language, and Turkish Sign Language. I found that the three sign languages are si...

  10. The sawtooth sign is predictive of obstructive sleep apnea.

    Science.gov (United States)

    Bourne, Michael H; Scanlon, Paul D; Schroeder, Darrell R; Olson, Eric J

    2017-05-01

    The sawtooth sign in spirometry is associated with redundant upper airway tissue and snoring, but its predictive value for identifying obstructive sleep apnea (OSA) is disputed. We retrospectively assessed the predictive value of the spirometric sawtooth sign in terms of the odds ratio (OR) of association with a diagnosis of OSA compared to those without the sign. Consecutive spirometry reports showing a sawtooth sign were identified from our laboratory. We identified 50 subjects with sawtooth sign and 100 control subjects without sawtooth sign, matched for age, BMI, and gender. The electronic medical record of each patient was queried for a diagnosis of OSA based on physician-reported diagnoses. Of the 50 subjects with sawtooth sign, 22 were found to have a current diagnosis of OSA (44%). Twenty-seven of the 100 controls (27%) also had OSA. From logistic regression analysis, sawtooth sign was associated with an increased likelihood of OSA (OR = 2.12, 95% C.I. 1.04 to 4.35). Similar results were obtained after adjustment for age, gender, pack years, and BMI (OR = 2.61, 95% C.I. 1.13 to 6.21). Patients with the sawtooth sign have greater odds of having a diagnosis of OSA compared with those without the sign. If prospectively evaluated, as a result of improved identification, we hypothesize that the sawtooth sign may show an even stronger association with OSA. This relatively common finding, which adds no cost to routine spirometry, may serve as an indicator for OSA workup for some individuals not already identified as having OSA.

  11. Chautauqua National Wildlife Refuge : Sign Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Chautauqua National Wildlife Refuge Sign Plan explains how signs are used on the Refuge to help guide and educate visitors. An inventory of current signs is...

  12. Learning Sign Language: A Whole Language Approach.

    Science.gov (United States)

    Burch, Daniel D.; Teller, Henry

    1996-01-01

    Applies principles of whole-language instruction to the teaching of sign language skills. Emphasis is on the holistic use of sign language in natural communicative situations. Some materials for this approach to sign language instruction are suggested. (DB)

  13. Synesthesia for manual alphabet letters and numeral signs in second-language users of signed languages.

    Science.gov (United States)

    Atkinson, Joanna; Lyons, Tanya; Eagleman, David; Woll, Bencie; Ward, Jamie

    2016-08-01

    Many synesthetes experience colors when viewing letters or digits. We document, for the first time, an analogous phenomenon among users of signed languages who showed color synesthesia for fingerspelled letters and signed numerals. Four synesthetes experienced colors when they viewed manual letters and numerals (in two cases, colors were subjectively projected on to the hands). There was a correspondence between the colors experienced for written graphemes and their manual counterparts, suggesting that the development of these two types of synesthesia is interdependent despite the fact that these systems are superficially distinct and rely on different perceptual recognition mechanisms in the brain.

  14. Parkinsonian axial signs in schizophrenia.

    Science.gov (United States)

    Morgante, Francesca; Barbui, Corrado; Tinazzi, Michele

    2017-03-01

    We have recently demonstrated evidence of nigro-striatal denervation, disease progression and response to levodopa in a subgroup of patients with schizophrenia who developed parkinsonism. In the present study, we investigated whether axial parkinsonian signs might be an early manifestation of parkinsonism in schizophrenia not necessarily related to chronic administration of antipsychotic drugs (AP) drugs. From a baseline cohort of 299 schizophrenic patients who did not satisfy the diagnostic criteria for parkinsonism (presence of at least two of the following appendicular signs: bradykinesia, tremor, rigidity), we identified a group of patients who manifested two out of three axial parkinsonian signs (abnormality of trunk posture, hypomimia and short-step gait). Accordingly, we obtained two sub-groups of patients with schizophrenia, with (Schiz-Axial, N = 26), and without parkinsonian axial signs (Schiz-NO-Axial, N = 273). Clinical and demographical variables were compared between groups. The motor section of the Unified Parkinson's disease rating scale (UPDRS) was employed to measure motor disability. Schiz-Axial patients were significantly older (p = 0.007) and had longer disease duration (p = 0.04) compared to Schiz-NO-Axial. The two groups did not differ for variables related to AP treatment. Total UPDRS motor score (p signs might be an early manifestation of parkinsonism in schizophrenia associated to older age and longer disease duration. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Talking with TV shows

    DEFF Research Database (Denmark)

    Sandvik, Kjetil; Laursen, Ditte

    2014-01-01

    User interaction with radio and television programmes is not a new thing. However, with new cross-media production concepts such as X Factor and Voice, this is changing dramatically. The second-screen logic of these productions encourages viewers, along with TV’s traditional one-way communication...... mode, to communicate on interactive (dialogue-enabling) devices such as laptops, smartphones and tablets. Using the TV show Voice as our example, this article shows how the technological and situational set-up of the production invites viewers to engage in new ways of interaction and communication....... More specifically, the article demonstrates how online comments posted on the day of Voice’s 2012 season finale can be grouped into four basic action types: (1) Invitation to consume content, (2) Request for participation, (3) Request for collaboration and (4) Online commenting. These action types...

  16. Um show de cacau

    OpenAIRE

    Rezende, José Francisco; UNIGRANRIO / PPGA; Mello, Simone; UNIGRANRIO

    2016-01-01

    O caso de ensino apresenta a trajetória de Alexandre Tadeu da Costa e da chocolateria Cacau Show. Seu objetivo é levar os estudantes a identificar alternativas e tomar decisões sobre posicionamento para continuidade do desenvolvimento de vantagens competitivas, sustentação de competência logística e possíveis abordagens ao mercado externo. 

  17. Electronic traffic signs: The interplay between hybrid and full matrix e-signs

    Energy Technology Data Exchange (ETDEWEB)

    Lucas-Alba, A.; Hernando Mazon, A.; Blanch Mico, A.M.; Gutierrez Perez, D.; Echeverria Villaspi, J.I.; Landa Tejero-Garces, N.

    2016-07-01

    Road signs constitute a complex and growing communication system where different elements (pictograms, shapes, texts, etc.) are combined following different strategies. In this paper we have confronted drivers with a number of messages (congestion or road works, before, between, after location/s) developed as an adaptation of Advance Location Signs (class G, 1c in the 1968 Convention) to electronic displays. We manipulate two main factors a) the reading strategy (top-down vs. bottom-up) and the type of matrix display (hybrid, dissociating pictogram and text, vs. full matrix), in a repeated measures experimental design. The time taken to answer and the response given (correct, incorrect) was measured for each of the 24 message-blocks. Results show that the organization of the elements displayed is a key determinant for driver comprehension. Further thoughts on the need to understand the interplay between the formats adopted by static vs electronic message signs are provided. (Author)

  18. The effects of sign design features on bicycle pictorial symbols for bicycling facility signs.

    Science.gov (United States)

    Oh, Kyunghui; Rogoff, Aaron; Smith-Jackson, Tonya

    2013-11-01

    The inanimate bicycle symbol has long been used to indicate the animate activity of bicycling facility signs. In contrast, either the inanimate bicycle symbol or the animate bicycle symbol has been used interchangeably for the standard pavement symbols in bike lanes. This has led to confusion among pedestrians and cyclists alike. The purpose of this study was to examine two different designs (inanimate symbol vs. animate symbol) involved in the evaluation of perceived preference and glance legibility, and investigate sign design features on bicycle pictorial symbols. Thirty-five participants compared current bicycle signs (inanimate symbols) to alternative designs (animate symbols) in a controlled laboratory setting. The results indicated that the alternative designs (animate symbols) showed better performance in both preference and glance legibility tests. Conceptual compatibility, familiarity, and perceptual affordances were found to be important factors as well. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  19. Hearing Status and Language Fluency as Predictors of Automatic Word and Sign Recognition.

    Science.gov (United States)

    Marschark, Marc; Shroyer, Edgar H.

    1993-01-01

    This study of the automatic word and sign recognition of 66 hearing and deaf adults found that responding in sign took longer and created more Stroop interference than responding orally, independent of hearing status. Deaf subjects showed greater automaticity in recognizing signs than words, whereas hearing subjects showed greater automaticity in…

  20. Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary Aspergillosis infection.

    Directory of Open Access Journals (Sweden)

    Juan Sainz

    Full Text Available The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated by the CCL2/CCR2 axis are critical steps in determining the host immune response to fungi. The present study was designed to investigate whether the presence of single nucleotide polymorphisms (SNPs within DC-SIGN, Dectin-1, Dectin-2, CCL2 and CCR2 genes influence the risk of developing Invasive Pulmonary Aspergillosis (IPA. Twenty-seven SNPs were selected using a hybrid functional/tagging approach and genotyped in 182 haematological patients, fifty-seven of them diagnosed with proven or probable IPA according to the 2008 EORTC/MSG criteria. Association analysis revealed that carriers of the Dectin-1(rs3901533 T/T and Dectin-1(rs7309123 G/G genotypes and DC-SIGN(rs4804800 G, DC-SIGN(rs11465384 T, DC-SIGN(7248637 A and DC-SIGN(7252229 C alleles had a significantly increased risk of IPA infection (OR = 5.59 95%CI 1.37-22.77; OR = 4.91 95%CI 1.52-15.89; OR = 2.75 95%CI 1.27-5.95; OR = 2.70 95%CI 1.24-5.90; OR = 2.39 95%CI 1.09-5.22 and OR = 2.05 95%CI 1.00-4.22, respectively. There was also a significantly increased frequency of galactomannan positivity among patients carrying the Dectin-1(rs3901533_T allele and Dectin-1(rs7309123_G/G genotype. In addition, healthy individuals with this latter genotype showed a significantly decreased level of Dectin-1 mRNA expression compared to C-allele carriers, suggesting a role of the Dectin-1(rs7309123 polymorphism in determining the levels of Dectin-1 and, consequently, the level of susceptibility to IPA infection. SNP-SNP interaction (epistasis analysis revealed significant interactions models including SNPs in Dectin-1, Dectin-2, CCL2 and CCR2 genes, with synergistic genetic effects. Although these results need to be further validated in larger cohorts, they suggest that Dectin-1, DC-SIGN, Dectin-2, CCL2 and CCR2 genetic variants influence the risk of IPA infection and might be useful in developing a risk

  1. CERN Single Sign On Solution

    CERN Document Server

    Ormancey, Emmanuel

    2008-01-01

    The need for Single Sign On has always been restricted by the absence of cross platform solutions: a single sign on working only on one platform or technology is nearly useless. The recent improvements in Web Services Federation (WS-Federation) standard enabling federation of identity, attribute, authentication and authorization information can now provide real extended Single Sign On solutions. Various solutions have been investigated at CERN and now, a Web SSO solution using some parts of WS-Federation technology is available. Using the Shibboleth Service Provider module for Apache hosted web sites and Microsoft ADFS as the identity provider linked to Active Directory user, users can now authenticate on any web application using a single authentication platform, providing identity, user information (building, phone...) as well as group membership enabling authorization possibilities. A typical scenario: a CERN user can now authenticate on a Linux/Apache website using Windows Integrated credentials, and his ...

  2. Signed Networks in Social Media

    CERN Document Server

    Leskovec, Jure; Kleinberg, Jon

    2010-01-01

    Relations between users on social media sites often reflect a mixture of positive (friendly) and negative (antagonistic) interactions. In contrast to the bulk of research on social networks that has focused almost exclusively on positive interpretations of links between people, we study how the interplay between positive and negative relationships affects the structure of on-line social networks. We connect our analyses to theories of signed networks from social psychology. We find that the classical theory of structural balance tends to capture certain common patterns of interaction, but that it is also at odds with some of the fundamental phenomena we observe --- particularly related to the evolving, directed nature of these on-line networks. We then develop an alternate theory of status that better explains the observed edge signs and provides insights into the underlying social mechanisms. Our work provides one of the first large-scale evaluations of theories of signed networks using on-line datasets, as ...

  3. Taking in a Show.

    Science.gov (United States)

    Boden, Timothy W

    2016-01-01

    Many medical practices have cut back on education and staff development expenses, especially those costs associated with conventions and conferences. But there are hard-to-value returns on your investment in these live events--beyond the obvious benefits of acquired knowledge and skills. Major vendors still exhibit their services and wares at many events, and the exhibit hall is a treasure-house of information and resources for the savvy physician or administrator. Make and stick to a purposeful plan to exploit the trade show. You can compare products, gain new insights and ideas, and even negotiate better deals with representatives anxious to realize returns on their exhibition investments.

  4. Malaysian sign language dataset for automatic sign language ...

    African Journals Online (AJOL)

    Hearing impaired individuals have issues to communicate with normal people. They have their own language called Sign Language (SL) to express their feeling or to communicate with others. As communication is an essential part of normal everyday life, it is particularly important for deaf people to communicate as ...

  5. SIGNS Molar tooth sign − looking beyond the obvious

    African Journals Online (AJOL)

    The molar tooth sign refers to the characteristic appearance on axial CT or MRI of enlarged and horizontally directed columnar structures on each side of the midline flanking a deep interpeduncular fossa.[1] This appearance is a result of absence or hypoplasia of the cerebellar vermis, lack of normal dorsal decussation and ...

  6. Exploring Sensor Gloves for Teaching Children Sign Language

    Directory of Open Access Journals (Sweden)

    Kirsten Ellis

    2012-01-01

    Full Text Available This research investigates if a computer and an alternative input device in the form of sensor gloves can be used in the process of teaching children sign language. The presented work is important, because no current literature investigates how sensor gloves can be used to assist children in the process of learning sign language. The research presented in this paper has been conducted by assembling hardware into sensor gloves, and by designing software capable of (i filtering out sensor noise, (ii detecting intentionally posed signs, and (iii correctly evaluating signals in signs posed by different children. Findings show that the devised technology can form the basis of a tool that teaches children sign language, and that there is a potential for further research in this area.

  7. Occurrence of spot signs from hypodensity areas on precontrast CT in intracerebral hemorrhage.

    Science.gov (United States)

    Nishiyama, Jun; Sorimachi, Takatoshi; Aoki, Rie; Inoue, Go; Matsumae, Mitsunori

    2017-05-01

    Both the spot signs, which is a bright spot on computed tomography angiography (CTA) source images, and hypodensity areas within a hematoma on precontrast CT scans, which presumably represent uncoagulated blood, have been reported to be predictive of hematoma enlargement in acute spontaneous intracerebral hematoma (ICH). The aim was to investigate densities on precontrast CT scans in an area within a hematoma that matched the locations of spot signs on CTA source images. In consecutive cases of spontaneous ICH admitted within 6 h after onset, early spot signs on CTA source images and delayed spot signs on delayed-phase CT scans 90 s after CTA were evaluated. Of 177 patients undergoing CTA, 41 (23.2%) showed early spot signs. Among 146 patients who underwent delayed-phase CT scans, 23 (15.8%) demonstrated delayed spot signs but not early spot signs. Spot signs originated from hypodensity areas, including densities signs and in 8 of 23 (34.8%) with delayed spot signs. Early spot signs arose from hypodensity areas more frequently than delayed spot signs (p signs, but in none with delayed spot signs. Some hypodensity areas within ICHs may indicate uncoagulated blood related to ongoing leakage, which are seen as spot signs. Minimum densities in hypodensity areas might correlate with the speed and volume of bleeding.

  8. The city as a sign

    DEFF Research Database (Denmark)

    Kharlamov, Nikita

    2012-01-01

    . This question is tackled through Jaan Valsiner’s notions of semiotic mediation and regulation. I specifically focus on spatial signs that humans use to regulate the meaning-making process that creates as meaningful what Georges Perec called species of spaces, such as towns and cities. “The city,” from...... this standpoint, becomes one of the most important signs that mediate and regulate our experience of environments we inhabit. I discuss a number of theoretical and methodological directions in which this framework could be further developed to revive the urban, or settlement, psychology, which failed to develop...

  9. Linear sign in cystic brain lesions ≥5 mm: A suggestive feature of perivascular space.

    Science.gov (United States)

    Sung, Jinkyeong; Jang, Jinhee; Choi, Hyun Seok; Jung, So-Lyung; Ahn, Kook-Jin; Kim, Bum-Soo

    2017-11-01

    To determine the prevalence of a linear sign within enlarged perivascular space (EPVS) and chronic lacunar infarction (CLI) ≥ 5 mm on T2-weighted imaging (T2WI) and time-of-flight (TOF) magnetic resonance angiography (MRA), and to evaluate the diagnostic value of the linear signs for EPVS over CLI. This study included 101 patients with cystic lesions ≥ 5 mm on brain MRI including TOF MRA. After classification of cystic lesions into EPVS or CLI, two readers assessed linear signs on T2WI and TOF MRA. We compared the prevalence and the diagnostic performance of linear signs. Among 46 EPVS and 51 CLI, 84 lesions (86.6%) were in basal ganglia. The prevalence of T2 and TOF linear signs was significantly higher in the EPVS than in the CLI (P linear signs showed high sensitivity (> 80%). TOF linear sign showed significantly higher specificity (100%) and accuracy (92.8% and 90.7%) than T2 linear sign (P linear signs were more frequently observed in EPVS than CLI. They showed high sensitivity in differentiation of them, especially for basal ganglia. TOF sign showed higher specificity and accuracy than T2 sign. • Linear sign is a suggestive feature of EPVS. • Time-of-flight magnetic resonance angiography can reveal the lenticulostriate artery within perivascular spaces. • Linear sign helps differentiation of EPVS and CLI, especially in basal ganglia.

  10. Clinical signs in the diagnosis of deep vein thrombosis.

    Science.gov (United States)

    Grüne, S; Orlik, J; Von Korn, H; Schacherer, D; Schlottmann, K; Brünnler, T

    2011-02-01

    Deep vein thrombosis (DVT) is an insidious disease wherein more than 15 different clinical signs are described. The aim of this work was to focus on these clinical signs and to test them for their importance in making a diagnosis of DVT. All patients treated with a tentative diagnosis of DVT in the emergency department were asked to take part in the study. Out of the 254 patients who were examined in order to exclude DVT, 204 patients agreed to participate in the study. The patients who agreed to take part were tested for fifteen clinical examination signs. The Wells score was then determined. Sixty-two were diagnosed with DVT. For 142 patients, DVT could be ruled out. The probability of DVT for 9 signs together is 88%, and for 3 signs is 78%. The negative predictive values are 91-95%. The combination of the clinical signs showed a specificity of 100%, independent if the patients were old, comorbid, and were diagnosed with the thrombosis in the lower limbs. The determination of the Wells score resulted in no convincing evidence for or against the diagnosis of DVT. We suggest a modified Wells score integrating missing clinical signs with more reliable predictive values. Even with the availability of ultrasound, clinical signs have not become superfluous. They are quick to carry out, safe, cheap and an important addition to the Wells score, particularly for multimorbid and elderly patients.

  11. Showing Value (Editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2009-06-01

    Full Text Available When Su Cleyle and I first decided to start Evidence Based Library and Information Practice, one of the things we agreed upon immediately was that the journal be open access. We knew that a major obstacle to librarians using the research literature was that they did not have access to the research literature. Although Su and I are both academic librarians who can access a wide variety of library and information literature from our institutions, we belong to a profession where not everyone has equal access to the research in our field. Without such access to our own body of literature, how can we ever hope for practitioners to use research evidence in their decision making? It would have been contradictory to the principles of evidence based library and information practice to do otherwise.One of the specific groups we thought could use such an open access venue for discovering research literature was school librarians. School librarians are often isolated and lacking access to the research literature that may help them prove to stakeholders the importance of their libraries and their role within schools. Certainly, school libraries have been in decline and the use of evidence to show value is needed. As Ken Haycock noted in his 2003 report, The Crisis in Canada’s School Libraries: The Case for Reform and Reinvestment, “Across the country, teacher-librarians are losing their jobs or being reassigned. Collections are becoming depleted owing to budget cuts. Some principals believe that in the age of the Internet and the classroom workstation, the school library is an artifact” (9. Within this context, school librarians are looking to our research literature for evidence of the impact that school library programs have on learning outcomes and student success. They are integrating that evidence into their practice, and reflecting upon what can be improved locally. They are focusing on students and showing the impact of school libraries and

  12. Real-Time Optical Antimicrobial Susceptibility Testing

    DEFF Research Database (Denmark)

    Fredborg, Marlene; Andersen, Klaus R; Jørgensen, Erik

    2013-01-01

    Rapid antibiotic susceptibility testing is in highly demand in health-care fields as antimicrobial resistant bacterial strains emerge and spread. Here we describe an optical screening system (oCelloScope), which based on time-lapse imaging of 96 bacteria-antibiotic combinations at a time, introdu......Rapid antibiotic susceptibility testing is in highly demand in health-care fields as antimicrobial resistant bacterial strains emerge and spread. Here we describe an optical screening system (oCelloScope), which based on time-lapse imaging of 96 bacteria-antibiotic combinations at a time......, introduces real-time detection of bacterial growth and antimicrobial susceptibility, with imaging material to support the automatically generated graphs. Automated antibiotic susceptibility tests of a monoculture showed statistically significant antibiotic effect within 6 minutes and within 30 minutes...

  13. Know the Signs of Concussion

    Science.gov (United States)

    ... if they don't play contact sports. A concussion is a mild traumatic brain injury -- or mTBI -- caused by a blow or ... to the head or body that causes the brain to shake, according to the Children's ... to get a concussion, it's important to know the signs of injury. ...

  14. Grammaticalization in American Sign Language.

    Science.gov (United States)

    Sexton, A. L.

    1999-01-01

    A study examined the process of grammaticalization in American Sign Language, examining basic principles and patterns and drawing parallels with oral language. More advanced stages of grammaticalization (involving fusion and affecting syntax) are examined in depth, leading to proposal of a temporal-ordering analysis to explain sequencing of verbal…

  15. Lexical Frequency in Sign Languages

    Science.gov (United States)

    Johnston, Trevor

    2012-01-01

    Measures of lexical frequency presuppose the existence of corpora, but true machine-readable corpora of sign languages (SLs) are only now being created. Lexical frequency ratings for SLs are needed because there has been a heavy reliance on the interpretation of results of psycholinguistic and neurolinguistic experiments in the SL research…

  16. Compiling a Sign Language Dictionary

    DEFF Research Database (Denmark)

    Kristoffersen, Jette Hedegaard; Troelsgård, Thomas

    2010-01-01

    As we began working on the Danish Sign Language (DTS) Dictionary, we soon realised the truth in the statement that a lexicographer has to deal with problems within almost any linguistic discipline. Most of these problems come down to establishing simple rules, rules that can easily be applied eve...

  17. CDC Vital Signs: Trucker Safety

    Science.gov (United States)

    ... Controls Search Form Controls Cancel Submit Search The CDC CDC A-Z Index MENU CDC A-Z SEARCH A B C D E ... Controls Search Form Controls Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is ...

  18. CDC Vital Signs: Hispanic Health

    Science.gov (United States)

    ... Controls Search Form Controls Cancel Submit Search The CDC CDC A-Z Index MENU CDC A-Z SEARCH A B C D E ... Controls Search Form Controls Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is ...

  19. CDC Vital Signs: Child Injury

    Science.gov (United States)

    ... Controls Search Form Controls Cancel Submit Search The CDC CDC A-Z Index MENU CDC A-Z SEARCH A B C D E ... Controls Search Form Controls Cancel Submit Search The CDC Vital Signs Note: Javascript is disabled or is ...

  20. Genetic susceptibility of periodontitis

    NARCIS (Netherlands)

    Laine, M.L.; Crielaard, W.; Loos, B.G.

    2012-01-01

    In this systematic review, we explore and summarize the peer-reviewed literature on putative genetic risk factors for susceptibility to aggressive and chronic periodontitis. A comprehensive literature search on the PubMed database was performed using the keywords ‘periodontitis’ or ‘periodontal

  1. Fourie susceptible.pmd

    African Journals Online (AJOL)

    Prof. Adipala Ekwamu

    a number of cultivars exhibited field resistance to halo blight and bacterial brown spot, all cultivars were more or less susceptible to .... Cerillos. Alubia. I. 91. 57. Kranskop. Red speckled sugar. II. 97. 63. OPS-RS1. Red speckled sugar. II. 96. 63. OPS-RS2. Red speckled sugar. I. 100. 61. OPS-RS3. Red speckled sugar. II. 97.

  2. 49 CFR 195.434 - Signs.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Signs. 195.434 Section 195.434 Transportation... PIPELINE Operation and Maintenance § 195.434 Signs. Each operator must maintain signs visible to the public around each pumping station and breakout tank area. Each sign must contain the name of the operator and a...

  3. 36 CFR 1001.10 - Symbolic signs.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Symbolic signs. 1001.10... signs. (a) The signs pictured in 36 CFR 1.10 provide general information and regulatory guidance in the area administered by the Presidio Trust. Certain of the signs designate activities that are either...

  4. 47 CFR 2.302 - Call signs.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Call signs. 2.302 Section 2.302... RULES AND REGULATIONS Call Signs and Other Forms of Identifying Radio Transmissions § 2.302 Call signs. The table which follows indicates the composition and blocks of international call signs available for...

  5. 36 CFR 1.10 - Symbolic signs.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Symbolic signs. 1.10 Section... PROVISIONS § 1.10 Symbolic signs. (a) The signs pictured below provide general information and regulatory guidance in park areas. Certain of the signs designate activities that are either allowed or prohibited...

  6. 49 CFR 193.2917 - Warning signs.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Warning signs. 193.2917 Section 193.2917...: FEDERAL SAFETY STANDARDS Security § 193.2917 Warning signs. (a) Warning signs must be conspicuously placed along each protective enclosure at intervals so that at least one sign is recognizable at night from a...

  7. 13 CFR 305.12 - Project sign.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Project sign. 305.12 Section 305... WORKS AND ECONOMIC DEVELOPMENT INVESTMENTS Requirements for Approved Projects § 305.12 Project sign. The... the construction period of a sign or signs at a conspicuous place at the Project site indicating that...

  8. Numeral Incorporation in Japanese Sign Language

    Science.gov (United States)

    Ktejik, Mish

    2013-01-01

    This article explores the morphological process of numeral incorporation in Japanese Sign Language. Numeral incorporation is defined and the available research on numeral incorporation in signed language is discussed. The numeral signs in Japanese Sign Language are then introduced and followed by an explanation of the numeral morphemes which are…

  9. Eye Gaze in Creative Sign Language

    Science.gov (United States)

    Kaneko, Michiko; Mesch, Johanna

    2013-01-01

    This article discusses the role of eye gaze in creative sign language. Because eye gaze conveys various types of linguistic and poetic information, it is an intrinsic part of sign language linguistics in general and of creative signing in particular. We discuss various functions of eye gaze in poetic signing and propose a classification of gaze…

  10. Lexicography and sign language engineering: the Zambian ...

    African Journals Online (AJOL)

    This article examines the genesis and implementation of a dictionary project for sign language, the Zambian Sign Language Dictionary Project, regarded as a first step towards the development of a Zambian National Sign Language. The article highlights the specificity of sign language lexicography. Keywords: american ...

  11. Domestic Cats (Felis silvestris catus Do Not Show Signs of Secure Attachment to Their Owners.

    Directory of Open Access Journals (Sweden)

    Alice Potter

    Full Text Available The Ainsworth Strange Situation Test (SST has been widely used to demonstrate that the bond between both children and dogs to their primary carer typically meets the requirements of a secure attachment (i.e. the carer being perceived as a focus of safety and security in otherwise threatening environments, and has been adapted for cats with a similar claim made. However methodological problems in this latter research make the claim that the cat-owner bond is typically a secure attachment, operationally definable by its behaviour in the SST, questionable. We therefore developed an adapted version of the SST with the necessary methodological controls which include a full counterbalance of the procedure. A cross-over design experiment with 20 cat-owner pairs (10 each undertaking one of the two versions of the SST first and continuous focal sampling was used to record the duration of a range of behavioural states expressed by the cats that might be useful for assessing secure attachment. Since data were not normally distributed, non-parametric analyses were used on those behaviours shown to be reliable across the two versions of the test (which excluded much cat behaviour. Although cats vocalised more when the owner rather the stranger left the cat with the other individual, there was no other evidence consistent with the interpretation of the bond between a cat and its owner meeting the requirements of a secure attachment. These results are consistent with the view that adult cats are typically quite autonomous, even in their social relationships, and not necessarily dependent on others to provide a sense of security and safety. It is concluded that alternative methods need to be developed to characterise the normal psychological features of the cat-owner bond.

  12. Young female patient with testosterone-producing adrenocortical adenoma also showing signs of subclinical Cushing's syndrome.

    Science.gov (United States)

    Murakami, Y; Sasaki, M; Sasano, H; Suzuki, T; Kitamura, N; Tomoi, M; Yorifuji, H; Koshimura, K; Kato, Y

    1995-04-01

    A 28-year old female patient with virilization due to left adrenocortical adenoma was studied. The patient had clinical features of hyperandrogenism such as hirsutism and a low pitched voice, but not of hypercorticoidism. Plasma testosterone and dehydroepiandrosterone-sulfate (DHEA-S) were high. Although the basal plasma cortisol concentration and urinary excretion of 17-hydroxycorticosteroids (17-OHCS) were within the normal range, the absence of diurnal variation in plasma cortisol and loss of suppressibility by dexamethasone suggested constitutive secretion of cortisol by the tumor. Inappropriate cortisol secretion was also supported by blunted ACTH response to provocative stimuli. After successful removal of the left adrenal tumor, such endocrinological abnormalities were all normalized. Immunohistochemical analysis revealed that tumor cells were positively stained for C21 hydroxylase cytochrome P-450 (P-450C21) and P-450(11) beta which convert 17-hydroxy (OH) progesterone to cortisol as well as P-450SCC, 3 beta-hydroxysteroid dehydrogenase and P-450(17) alpha which are involved in testosterone biosynthesis. These findings suggest that adrenocortical adenoma secretes predominantly testosterone and constitutively cortisol in a young woman patient with virilization.

  13. Patients with eating disorders showed no signs of coeliac disease before and after nutritional intervention.

    Science.gov (United States)

    Kaltsa, Maria; Garoufi, Anastasia; Tsitsika, Artemis; Tsirogianni, Alexandra; Papasteriades, Chryssa; Kossiva, Lydia

    2015-07-01

    This study assessed the presence of specific antibodies for coeliac disease in outpatients suffering from eating disorders before and after nutritional intervention. We also evaluated whether those patients should undergo regular screening for coeliac disease. The sample consisted of 154 patients with a mean age of 16.7 years - ranging from one to 19 years of age - suffering from eating disorders. Serology screening for coeliac disease and total immunoglobulin A (IgA) levels was evaluated in the 154 children before the nutritional intervention and in 104 patients after the intervention. The patients consumed an adequate amount of gluten in both phases. Postintervention evaluation revealed that 92 patients (88.5%) achieved a normal body weight, while the remaining 12 (11.5%) became obese. Postprandial abdominal discomfort and pain were resolved. The serology tests were negative in all patients, before and after intervention. None displayed IgA deficiency. To the best of our knowledge, this was the first prospective study where patients underwent a screening serology for coeliac disease before and after nutritional intervention. No indication of the coexistence of eating disorders and coeliac disease was documented, and the patients in our study were unlikely to require regular screening for coeliac disease. ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  14. Amphibian Chytrid Fungus in Madagascar neither Shows Widespread Presence nor Signs of Certain Establishment.

    Directory of Open Access Journals (Sweden)

    Jonathan E Kolby

    Full Text Available The global spread of amphibian chytrid fungus (Batrachochytrium dendrobatidis, Bd is associated with amphibian mass mortality, population decline, and extinction. Over the past decade, concern has been expressed for the potential introduction of Bd to Madagascar, a global hotspot of amphibian biodiversity. Following years without detection, widespread Bd presence in Madagascar has now been reported (Bletz et al. 2015a, raising international conservation concern. Before reacting to this finding with a significant management response, the accuracy and context of the data warrant cautious review. Re-examination of a 10-year dataset together with results from more recent surveillance (Kolby et al. 2015 does not yet demonstrate widespread Bd presence. Detection of Bd at "positive" locations in Madagascar has been inconsistent for unknown reasons. Whether Bd is established in Madagascar (i.e. populations are self-sustaining or instead requires continued introduction to persist also remains uncertain. The deployment of emergency conservation rescue initiatives is expected to target areas where the distribution of Bd and the risk of chytridiomycosis endangering amphibians is believed to overlap. Thus, erroneous description of Bd presence would misdirect limited conservation resources. Standardized surveillance and confirmatory surveys are now imperative to reliably characterize the distribution, potential spread, virulence and overall risk of Bd to amphibians in Madagascar.

  15. Monomorphic genotypes within a generalist lineage of Campylobacter jejuni show signs of global dispersion.

    Science.gov (United States)

    Llarena, Ann-Katrin; Zhang, Ji; Vehkala, Minna; Välimäki, Niko; Hakkinen, Marjaana; Hänninen, Marja-Liisa; Roasto, Mati; Mäesaar, Mihkel; Taboada, Eduardo; Barker, Dillon; Garofolo, Giuliano; Cammà, Cesare; Di Giannatale, Elisabetta; Corander, Jukka; Rossi, Mirko

    2016-10-01

    The decreased costs of genome sequencing have increased the capability to apply whole-genome sequencing to epidemiological surveillance of zoonotic Campylobacter jejuni. However, knowledge of the genetic diversity of this bacteria is vital for inferring relatedness between epidemiologically linked isolates and a necessary prerequisite for correct application of this methodology. To address this issue in C. jejuni we investigated the spatial and temporal signals in the genomes of a major clonal complex and generalist lineage, ST-45 CC, by analysing the population structure and genealogy as well as applying genome-wide association analysis of 340 isolates from across Europe collected over a wide time range. The occurrence and strength of the geographical signal varied between sublineages and followed the clonal frame when present, while no evidence of a temporal signal was found. Certain sublineages of ST-45 formed discrete and genetically isolated clades containing isolates with extremely similar genomes regardless of time and location of sampling. Based on a separate data set, these monomorphic genotypes represent successful C. jejuni clones, possibly spread around the globe by rapid animal (migrating birds), food or human movement. In addition, we observed an incongruence between the genealogy of the strains and multilocus sequence typing (MLST), challenging the existing clonal complex definition and the use of whole-genome gene-by-gene hierarchical nomenclature schemes for C. jejuni.

  16. Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

    Directory of Open Access Journals (Sweden)

    van Horssen Jack

    2012-07-01

    Full Text Available Abstract Background In brain tissues from multiple sclerosis (MS patients, clusters of activated HLA-DR-expressing microglia, also referred to as preactive lesions, are located throughout the normal-appearing white matter. The aim of this study was to gain more insight into the frequency, distribution and cellular architecture of preactive lesions using a large cohort of well-characterized MS brain samples. Methods Here, we document the frequency of preactive lesions and their association with distinct white matter lesions in a cohort of 21 MS patients. Immunohistochemistry was used to gain further insight into the cellular and molecular composition of preactive lesions. Results Preactive lesions were observed in a majority of MS patients (67% irrespective of disease duration, gender or subtype of disease. Microglial clusters were predominantly observed in the vicinity of active demyelinating lesions and are not associated with T cell infiltrates, axonal alterations, activated astrocytes or blood–brain barrier disruption. Microglia in preactive lesions consistently express interleukin-10 and TNF-α, but not interleukin-4, whereas matrix metalloproteases-2 and −9 are virtually absent in microglial nodules. Interestingly, key subunits of the free-radical-generating enzyme NADPH oxidase-2 were abundantly expressed in microglial clusters. Conclusions The high frequency of preactive lesions suggests that it is unlikely that most of them will progress into full-blown demyelinating lesions. Preactive lesions are not associated with blood–brain barrier disruption, suggesting that an intrinsic trigger of innate immune activation, rather than extrinsic factors crossing a damaged blood–brain barrier, induces the formation of clusters of activated microglia.

  17. Solomon Islands Largest Hawksbill Turtle Rookery Shows Signs of Recovery after 150 Years of Excessive Exploitation

    Science.gov (United States)

    Hamilton, Richard J.; Bird, Tomas; Gereniu, Collin; Pita, John; Ramohia, Peter C.; Walter, Richard; Goerlich, Clara; Limpus, Colin

    2015-01-01

    The largest rookery for hawksbill turtles in the oceanic South Pacific is the Arnavon Islands, which are located in the Manning Strait between Isabel and Choiseul Province, Solomon Islands. The history of this rookery is one of overexploitation, conflict and violence. Throughout the 1800s Roviana headhunters from New Georgia repeatedly raided the Manning Strait to collect hawksbill shell which they traded with European whalers. By the 1970s the Arnavons hawksbill population was in severe decline and the national government intervened, declaring the Arnavons a sanctuary in 1976. But this government led initiative was short lived, with traditional owners burning down the government infrastructure and resuming intensive harvesting in 1982. In 1991 routine beach monitoring and turtle tagging commenced at the Arnavons along with extensive community consultations regarding the islands’ future, and in 1995 the Arnavon Community Marine Conservation Area (ACMCA) was established. Around the same time national legislation banning the sale of all turtle products was passed. This paper represents the first analysis of data from 4536 beach surveys and 845 individual turtle tagging histories obtained from the Arnavons between 1991-2012. Our results and the results of others, reveal that many of the hawksbill turtles that nest at the ACMCA forage in distant Australian waters, and that nesting on the Arnavons occurs throughout the year with peak nesting activity coinciding with the austral winter. Our results also provide the first known evidence of recovery for a western pacific hawksbill rookery, with the number of nests laid at the ACMCA and the remigration rates of turtles doubling since the establishment of the ACMCA in 1995. The Arnavons case study provides an example of how changes in policy, inclusive community-based management and long term commitment can turn the tide for one of the most charismatic and endangered species on our planet. PMID:25853880

  18. Diversion or Democratization: Do Rural, Hispanic, Community College Students Show Signs of Academic Undermatch?

    Science.gov (United States)

    Freeman, Eric

    2017-01-01

    This study examines the relationship between academic undermatch theory and the college-going decisions, experiences, and aspirations of first-generation, rural Hispanic community college students in the new destination meatpacking town of Winstead, Kansas. Ethnographic data from rural high school guidance counselors, community college faculty,…

  19. Amphibian Chytrid Fungus in Madagascar neither Shows Widespread Presence nor Signs of Certain Establishment.

    Science.gov (United States)

    Kolby, Jonathan E; Skerratt, Lee F

    2015-01-01

    The global spread of amphibian chytrid fungus (Batrachochytrium dendrobatidis, Bd) is associated with amphibian mass mortality, population decline, and extinction. Over the past decade, concern has been expressed for the potential introduction of Bd to Madagascar, a global hotspot of amphibian biodiversity. Following years without detection, widespread Bd presence in Madagascar has now been reported (Bletz et al. 2015a), raising international conservation concern. Before reacting to this finding with a significant management response, the accuracy and context of the data warrant cautious review. Re-examination of a 10-year dataset together with results from more recent surveillance (Kolby et al. 2015) does not yet demonstrate widespread Bd presence. Detection of Bd at "positive" locations in Madagascar has been inconsistent for unknown reasons. Whether Bd is established in Madagascar (i.e. populations are self-sustaining) or instead requires continued introduction to persist also remains uncertain. The deployment of emergency conservation rescue initiatives is expected to target areas where the distribution of Bd and the risk of chytridiomycosis endangering amphibians is believed to overlap. Thus, erroneous description of Bd presence would misdirect limited conservation resources. Standardized surveillance and confirmatory surveys are now imperative to reliably characterize the distribution, potential spread, virulence and overall risk of Bd to amphibians in Madagascar.

  20. Solomon Islands largest hawksbill turtle rookery shows signs of recovery after 150 years of excessive exploitation.

    Directory of Open Access Journals (Sweden)

    Richard J Hamilton

    Full Text Available The largest rookery for hawksbill turtles in the oceanic South Pacific is the Arnavon Islands, which are located in the Manning Strait between Isabel and Choiseul Province, Solomon Islands. The history of this rookery is one of overexploitation, conflict and violence. Throughout the 1800s Roviana headhunters from New Georgia repeatedly raided the Manning Strait to collect hawksbill shell which they traded with European whalers. By the 1970s the Arnavons hawksbill population was in severe decline and the national government intervened, declaring the Arnavons a sanctuary in 1976. But this government led initiative was short lived, with traditional owners burning down the government infrastructure and resuming intensive harvesting in 1982. In 1991 routine beach monitoring and turtle tagging commenced at the Arnavons along with extensive community consultations regarding the islands' future, and in 1995 the Arnavon Community Marine Conservation Area (ACMCA was established. Around the same time national legislation banning the sale of all turtle products was passed. This paper represents the first analysis of data from 4536 beach surveys and 845 individual turtle tagging histories obtained from the Arnavons between 1991-2012. Our results and the results of others, reveal that many of the hawksbill turtles that nest at the ACMCA forage in distant Australian waters, and that nesting on the Arnavons occurs throughout the year with peak nesting activity coinciding with the austral winter. Our results also provide the first known evidence of recovery for a western pacific hawksbill rookery, with the number of nests laid at the ACMCA and the remigration rates of turtles doubling since the establishment of the ACMCA in 1995. The Arnavons case study provides an example of how changes in policy, inclusive community-based management and long term commitment can turn the tide for one of the most charismatic and endangered species on our planet.

  1. Design semiotica: the sign as event

    OpenAIRE

    Waller, Christopher Leonard

    2017-01-01

    Designers rely on the consistent interpretation of visual signs to achieve stable, effective communication. When signs produce unpredictable, ambiguous, or non-sensical interpretations, they are usually disregarded as signifying errors. However, anomalous signs actually reveal insights into the dynamic nature of graphic semiosis. What is the significance of signs that unexpectedly change their identity? How can communication designers interpret phenomena produced by the actions of signs? What...

  2. Spanish sign language interpreter for mexican linguistics

    OpenAIRE

    Juan Barragán, Francisco Javier; Pérez Grana, José Arturo; Cervantes, Francisco; Schwarzblat y Katz, Morris; Olide Márquez, María Guadalupe; Pérez Sánchez, Ana Paola

    2013-01-01

    We present here the first visual interface for a Mexican Spanish Sign Language translator on its first development stage: sign-writing recognition. The software was developed for the unique characteristics of Mexican linguistics and was designed in order to use sentences or a sequence of signs in sign-writing system which are decoded by the program and converted into a series of images with movement that correspond to the Mexican sign language system. Using a lexical, syntactic and semantic...

  3. Signs, dispositions, and semiotic scaffolding.

    Science.gov (United States)

    Fernández, Eliseo

    2015-12-01

    In theoretical work we distinguish living beings from inanimate objects on the basis of some paramount attributes, such as agency and autonomy. These abstract features are not directly accessible to our scrutiny, but we surmise their nature through observation of the purpose-oriented behavior of organisms. I intend to show that organismal purposefulness springs from the intrinsic, constitutive kind of finality that is the hallmark of all semiotic transactions. To this aim I develop a dispositionalist account of organismal causation based on a distinction between two kinds of causal dispositions: fixed (efficient) dispositions and traveling dispositions. Fixed dispositions are rigidly attached to physical structures and processes; these are the dispositions regularly invoked in current discussions of causal explanation. Traveling dispositions are able to move freely from one location to another by becoming embodied into suitable supporting media. I introduce these notions to articulate a view of semiosis I deem best suited to the life sciences, and contend that sign tokens are vehicles of traveling dispositions. This account places the origin of purposive behavior at the interaction of physical and semiotic causation. To properly motivate the discussion I briefly review some recent developments in the philosophy of science concerning various forms of causation invoked by scientists across disciplines to frame explanations and make predictions. The ensuing discussion gives particular prominence to mechanistic (as distinct from mechanicist) explanatory accounts of biological phenomena. This review is followed by a brief characterization of a "nomological machine," a comprehensive schema introduced and developed by Nancy Cartwright with the goal of explaining causal mechanisms in a general setting. By capitalizing on this model's heuristic virtues I seek to formulate a compelling view of the interactions between physical and semiotic causation at play in semiotic

  4. Medical image of the week: coffee bean and whirlpool signs

    Directory of Open Access Journals (Sweden)

    Bartolome B

    2016-01-01

    Full Text Available A 79-year-old woman with a history of Parkinson’s disease presented with altered mental status, poor oral intake, and multiple episodes of nausea and vomiting. An abdominal x-ray demonstrated dilated loops of bowel and the coffee bean sign concerning for sigmoid volvulus (Figure 1. The coffee bean sign occurs when a thick “inner wall” represents the double wall thickness of opposed loops of bowel while the thinner outer walls due single thickness. A contrast CT abdomen showed dilated sigmoid loop and whirlpool sign confirming sigmoid volvulus (Figure 2. She underwent a total colectomy with ileorectal anastomosis and full recovery.

  5. Old Signs, New Signs, Whose Signs? Sociolinguistic Variation in the NZSL Lexicon

    Science.gov (United States)

    McKee, Rachel; McKee, David

    2011-01-01

    Lexicographers, teachers and interpreters of New Zealand Sign Language (NZSL) are challenged by the degree of lexical variation that exists in this young language. For instance, most numerals between one and twenty have two or more variants in common use (McKee, McKee, and Major 2008), a situation that contrasts with most established spoken…

  6. Magnetic field control of 90 Degree-Sign , 180 Degree-Sign , and 360 Degree-Sign domain wall resistance

    Energy Technology Data Exchange (ETDEWEB)

    Majidi, Roya, E-mail: royamajidi@gmail.com [Department of Physics, Shahid Rajaee Teacher Training University, Lavizan, 16788-15811 Tehran (Iran, Islamic Republic of)

    2012-10-01

    In the present work, we have compared the resistance of the 90 Degree-Sign , 180 Degree-Sign , and 360 Degree-Sign domain walls in the presence of external magnetic field. The calculations are based on the Boltzmann transport equation within the relaxation time approximation. One-dimensional Neel-type domain walls between two domains whose magnetization differs by angle of 90 Degree-Sign , 180 Degree-Sign , and 360 Degree-Sign are considered. The results indicate that the resistance of the 360 Degree-Sign DW is more considerable than that of the 90 Degree-Sign and 180 Degree-Sign DWs. It is also found that the domain wall resistance can be controlled by applying transverse magnetic field. Increasing the strength of the external magnetic field enhances the domain wall resistance. In providing spintronic devices based on magnetic nanomaterials, considering and controlling the effect of domain wall on resistivity are essential.

  7. Type of Iconicity Matters in the Vocabulary Development of Signing Children

    Science.gov (United States)

    Ortega, Gerardo; Sümer, Beyza; Özyürek, Asli

    2017-01-01

    Recent research on signed as well as spoken language shows that the iconic features of the target language might play a role in language development. Here, we ask further whether different types of iconic depictions modulate children's preferences for certain types of sign-referent links during vocabulary development in sign language. Results from…

  8. The effect of sign language structure on complex word reading in Chinese deaf adolescents.

    Science.gov (United States)

    Lu, Aitao; Yu, Yanping; Niu, Jiaxin; Zhang, John X

    2015-01-01

    The present study was carried out to investigate whether sign language structure plays a role in the processing of complex words (i.e., derivational and compound words), in particular, the delay of complex word reading in deaf adolescents. Chinese deaf adolescents were found to respond faster to derivational words than to compound words for one-sign-structure words, but showed comparable performance for two-sign-structure words. For both derivational and compound words, response latencies to one-sign-structure words were shorter than to two-sign-structure words. These results provide strong evidence that the structure of sign language affects written word processing in Chinese. Additionally, differences between derivational and compound words in the one-sign-structure condition indicate that Chinese deaf adolescents acquire print morphological awareness. The results also showed that delayed word reading was found in derivational words with two signs (DW-2), compound words with one sign (CW-1), and compound words with two signs (CW-2), but not in derivational words with one sign (DW-1), with the delay being maximum in DW-2, medium in CW-2, and minimum in CW-1, suggesting that the structure of sign language has an impact on the delayed processing of Chinese written words in deaf adolescents. These results provide insight into the mechanisms about how sign language structure affects written word processing and its delayed processing relative to their hearing peers of the same age.

  9. Double line sign: a helpful sonographic sign to detect occult fractures of the proximal humerus

    Energy Technology Data Exchange (ETDEWEB)

    Rutten, Matthieu J.C.M.; Jager, Gerrit J. [Jeroen Bosch Hospital, Department of Radiology, Hertogenbosch (Netherlands); Waal malefijt, Maarten C. de [University Medical Center Nijmegen, Department of Orthopedic Surgery, Nijmegen (Netherlands); Blickman, Johan G. [University Medical Center Nijmegen, Department of Radiology, Nijmegen (Netherlands)

    2007-03-15

    The aim of this study was to describe a new sonographic sign of bone fracture and to determine if it can be helpful in decreasing the number of missed fractures of the proximal humerus. Ultrasound (US) of the shoulder was performed in 57 consecutive patients with shoulder pain and/or disability following trauma. All cases were prospectively reviewed for the presence of a humeral fracture. Sonographic signs of fractures, with special emphasis on what was termed the 'double line sign' (DLS), were assessed. Plain radiography was considered the standard of reference and in equivocal cases magnetic resonance imaging (MRI). Twenty-eight patients had a tuberosity complex fracture, which were all detected at US examination. Sonographic features of a fracture were periosteal elevation, corticol bone discontinuity, step-off deformity or a combination of these findings. This study showed that in 26 (93%) patients an additional sonographic feature, a DLS, could be demonstrated. The DLS is a helpful and probably reliable sonographic sign to indicate a humeral fracture. High-spatial-resolution US substantially increases the detection of fractures of the proximal humerus and should be considered as an alternative diagnostic tool prior to computed tomography (CT), MRI and arthroscopy in patients with persisting shoulder pain and/or disability following trauma. (orig.)

  10. New insights into the clinical signs of supraventricular tachycardia: The "sign of lace-tying".

    Science.gov (United States)

    Blommaert, Dominique; Dormal, Fabien; Deceuninck, Olivier; Xhaet, Olivier; Ballant, Elisabeth; De Roy, Luc

    2018-01-01

    Supraventricular tachycardias (SVT) are a common arrhythmia therefore an accurate diagnosis is of clinical importance. Although an ECG performed during tachycardia greatly aids diagnosis, patient history and predisposing factors also improve diagnostic accuracy. This prospective study included 100 consecutive patients undergoing electrophysiological study for SVT with the aim to reassess their clinical characteristics and describe frequent predisposing factors, such as the "sign of lace-tying" that to our knowledge has not previously been reported. Each patient completed an extensive questionnaire (70 questions) during their hospital stay. Our series comprised: 67% of patients with atrioventricular nodal reentrant tachycardia (AVNRT); 24% with an accessory pathway; and 9% presented atrial tachycardia. Half of the population were male and 29% of the cohort presented hypertension. Syncope during tachycardia appeared in 15% of patients, dizziness in 52% and thoracic pain in 59%. We encountered a predisposing risk factor for SVT in 53% of cases; with 32% exhibiting an anteflexion of the trunk termed the "sign of lace-tying." Data also showed that younger patients tended to present AVRT and regular pounding in the neck appeared only in patients with AVNRT. Overall, our study has highlighted the importance of considering clinical signs and patient characteristics both before and during SVT for the precise diagnosis of paroxysmal SVT. Furthermore, 32% of patients presented the "sign of lace-tying" or body position change before SVT, implying a diagnosis of SVT. © 2017 Wiley Periodicals, Inc.

  11. Vital Signs - Child Passenger Safety

    Centers for Disease Control (CDC) Podcasts

    2014-02-04

    This podcast is based on the February 2014 CDC Vital Signs report. Over the past 10 years, more than 9,000 children 12 and under died in motor vehicle crashes, and a third who died in 2011 weren't buckled up. Buckling up is the best way to reduce injuries and save lives.  Created: 2/4/2014 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 2/4/2014.

  12. Deaf children learning to sign

    Directory of Open Access Journals (Sweden)

    Jim Kyle

    2001-01-01

    Full Text Available It used to be thought that deaf children had a language difficulty. Research we have carried out on deaf children in deaf families from the age of three months, indicates that deaf children learn sign language as effectively as hearing children learn to speak. In contrast, deaf children from hearing homes, even in signing programmes at school lag behind in the acquisition of sign language even up to the age of 11 years. Some initial intervention work has been carried out with families to introduce sign language earlier and several possible means of improving the language environment of deaf children are explored in this paper. Costumava-se pensar que as crianças surdas tinham dificuldade de linguagem. Uma pesquisa que realizamos com crianças surdas, de famílias surdas, a partir de 3 meses de idade, indica que crianças surdas aprendem a língua de sinais tão eficazmente quanto crianças ouvintes aprendem a falar. Em contraste, crianças surdas, de lares ouvintes, mesmo estando em programas para o aprendizado de sinais na escola, ficam atrás na aquisição da língua de sinais até a idade de 11 anos de idade. Alguns trabalhos iniciais de intervenção, que têm sido realizados com as famílias para introduzir a língua de sinais mais cedo, bem como vários meios possíveis de enriquecer o meio lingüístico de crianças surdas são explorados nesse artigo.

  13. Vital Signs-Secondhand Smoke

    Centers for Disease Control (CDC) Podcasts

    2015-02-03

    This podcast is based on the February 2015 CDC Vital Signs report. Secondhand smoke kills more than 400 infants and 41,000 adult nonsmokers every year. Learn what can be done to prevent secondhand smoke exposure.  Created: 2/3/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 2/3/2015.

  14. Genetic Susceptibility to Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Sanja Kovacic

    2012-01-01

    Full Text Available Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic ground significantly influences susceptibility to atherosclerotic vascular diseases. Besides further investigations of monogenetic diseases, candidate genes, genetic polymorphisms, and susceptibility loci associated with atherosclerotic diseases have been identified in recent years, and their number is rapidly increasing. This paper discusses main genetic investigations fields associated with human atherosclerotic vascular diseases. The paper concludes with a discussion of the directions and implications of future genetic research in arteriosclerosis with an emphasis on prospective prediction from an early age of individuals who are predisposed to develop premature atherosclerosis as well as to facilitate the discovery of novel drug targets.

  15. The "SignOn"-Model for Teaching Written Language to Deaf People

    OpenAIRE

    Marlene Hilzensauer; Franz Dotter

    2012-01-01

    This paper shows a method of teaching written language to deaf people using sign language as the language of instruction. Written texts in the target language are combined with sign language videos which provide the users with various modes of translation (words/phrases/sentences). As examples, two EU projects for English for the Deaf are presented which feature English texts and translations into the national sign languages of all the partner countries plus signed grammar explanations and in...

  16. The Role of Sign Phonology and Iconicity During Sign Processing: The Case of Deaf Children

    NARCIS (Netherlands)

    Ormel, E.A.; Hermans, D.; Knoors, H.E.T.; Verhoeven, L.T.W.

    2009-01-01

    To investigate the influence of sign phonology and iconicity during sign processing in deaf children, the roles of these sign features were examined using an experimental sign-picture verification paradigm. Participants had to make decisions about sign-picture pairs, manipulated according to

  17. Upgoing thumb sign: A sensitive indicator of brain involvement?

    Science.gov (United States)

    Hachinski, Vladimir; Alsubaie, Rasha; Azarpazhooh, Mahmoud Reza

    2017-07-25

    To assess the frequency of this finding in patients with minor stroke and TIAs compared to those with stroke mimics and to evaluate the level of agreement between examiners to detect an upgoing thumb sign. We previously reported an upgoing thumb sign as a subtle clinical finding in patients with transient ischemic attacks or minor stroke. In this study conducted between March 2016 and October 2016 at the Stroke Prevention Clinic at University Hospital, University of Western Ontario, London, Canada, participants were examined independently by stroke faculty and fellows who were blinded to each other's findings. The frequency of the upgoing thumb sign in patients with minor or threatened stroke was compared to that in patients with stroke mimics, and the level of agreement between examiners and clinical findings was assessed with the Cohen κ test. The upgoing thumb sign was observed more frequently in those with minor stroke/TIA than in those with stroke mimics (p = 0.001). A substantial level of agreement between examiners was recorded in the detection of the thumb sign (κ: right 0.71, left 0.78). In addition, an upgoing thumb sign showed a substantial level of agreement with the patient's symptoms (examiner 1: κ = 0.65, p thumb sign is a sensitive and reliable indicator of brain involvement. This examination is noninvasive, easy, reliable, and highly compatible with and confirmatory of the patient's symptoms. © 2017 American Academy of Neurology.

  18. Fast micrographia: An unusual but distinctive sign

    Directory of Open Access Journals (Sweden)

    Umaiorubahan Meenakshisundaram

    2013-01-01

    Full Text Available Fast micrographia is a rare clinical sign, which is reported in patients with pallidal pathology. A 68-year-old male presented with hypophonia and short shuffling gait with decreased arm swing. About 3 weeks before, he had an acute myocardial infarction and a period of hemodynamic and respiratory distress during which he required mechanical ventilatory support. He was found to have a fast handwriting with micrographia from the outset. His rapid alternating hand and finger movements were normal. Magnetic resonance imaging (MRI of the brain showed features of hypoxic ischemic encephalopathy including hyperintensities on T1 and T2 weighted images in the globus pallidus, and putamen bilaterally.

  19. A multi-annual landslide inventory for the assessment of shallow landslide susceptibility - Two test cases in Vorarlberg, Austria

    Science.gov (United States)

    Zieher, Thomas; Perzl, Frank; Rössel, Monika; Rutzinger, Martin; Meißl, Gertraud; Markart, Gerhard; Geitner, Clemens

    2016-04-01

    Geomorphological landslide inventories provide crucial input data for any study on the assessment of landslide susceptibility, hazard or risk. Several approaches for assessing landslide susceptibility have been proposed to identify areas particularly vulnerable to this natural hazard. What they have in common is the need for data of observed landslides. Therefore the first step of any study on landslide susceptibility is usually the compilation of a geomorphological landslide inventory using a geographical information system. Recent research has proved the feasibility of orthophoto interpretation for the preparation of an inventory aimed at the delineation of landslides with the use of distinctive signs in the imagery data. In this study a multi-annual landslide inventory focusing on shallow landslides (i.e. translational soil slides of 0-2 m in depth) was compiled for two study areas in Vorarlberg (Austria) from the interpretation of nine orthophoto series. In addition, derivatives of two generations of airborne laser scanning data aided the mapping procedure. Landslide scar areas were delineated on the basis of a high-resolution differential digital terrain model. The derivation of landslide volumes, depths and depth-to-length ratios are discussed. Results show that most mapped landslides meet the definition of a shallow landslide. The inventory therefore provides the data basis for the assessment of shallow landslide susceptibility and allows for the application of various modelling techniques.

  20. A comparative assessment of decision trees algorithms for flash flood susceptibility modeling at Haraz watershed, northern Iran.

    Science.gov (United States)

    Khosravi, Khabat; Pham, Binh Thai; Chapi, Kamran; Shirzadi, Ataollah; Shahabi, Himan; Revhaug, Inge; Prakash, Indra; Tien Bui, Dieu

    2018-02-01

    Floods are one of the most damaging natural hazards causing huge loss of property, infrastructure and lives. Prediction of occurrence of flash flood locations is very difficult due to sudden change in climatic condition and manmade factors. However, prior identification of flood susceptible areas can be done with the help of machine learning techniques for proper timely management of flood hazards. In this study, we tested four decision trees based machine learning models namely Logistic Model Trees (LMT), Reduced Error Pruning Trees (REPT), Naïve Bayes Trees (NBT), and Alternating Decision Trees (ADT) for flash flood susceptibility mapping at the Haraz Watershed in the northern part of Iran. For this, a spatial database was constructed with 201 present and past flood locations and eleven flood-influencing factors namely ground slope, altitude, curvature, Stream Power Index (SPI), Topographic Wetness Index (TWI), land use, rainfall, river density, distance from river, lithology, and Normalized Difference Vegetation Index (NDVI). Statistical evaluation measures, the Receiver Operating Characteristic (ROC) curve, and Freidman and Wilcoxon signed-rank tests were used to validate and compare the prediction capability of the models. Results show that the ADT model has the highest prediction capability for flash flood susceptibility assessment, followed by the NBT, the LMT, and the REPT, respectively. These techniques have proven successful in quickly determining flood susceptible areas. Copyright © 2018 Elsevier B.V. All rights reserved.

  1. Insecticide susceptibility of Aedes albopictus and Ae. aegypti from Brazil and the Swiss-Italian border region.

    Science.gov (United States)

    Suter, Tobias; Crespo, Mônica Maria; de Oliveira, Mariana Francelino; de Oliveira, Thaynan Sama Alves; de Melo-Santos, Maria Alice Varjal; de Oliveira, Cláudia Maria Fontes; Ayres, Constância Flávia Junqueira; Barbosa, Rosângela Maria Rodrigues; Araújo, Ana Paula; Regis, Lêda Narcisa; Flacio, Eleonora; Engeler, Lukas; Müller, Pie; Silva-Filha, Maria Helena Neves Lobo

    2017-09-19

    Aedes aegypti and Ae. albopictus are two highly invasive mosquito species, both vectors of several viruses, including dengue, chikungunya and Zika. While Ae. aegypti is the primary vector in the tropics and sub-tropics, Ae. albopictus is increasingly under the public health watch as it has been implicated in arbovirus-transmission in more temperate regions, including continental Europe. Vector control using insecticides is the pillar of most control programmes; hence development of insecticide resistance is of great concern. As part of a Brazilian-Swiss Joint Research Programme we set out to assess whether there are any signs of existing or incipient insecticide resistance primarily against the larvicide Bacillus thuringiensis svar. israelensis (Bti), but also against currently applied and potentially alternative insecticides in our areas, Recife (Brazil) and the Swiss-Italian border region. Following World Health Organization guidelines, dose-response curves for a range of insecticides were established for both colonized and field caught Ae. aegypti and Ae. albopictus. The larvicides included Bti, two of its toxins, Cry11Aa and Cry4Ba, Lysinibacillus sphaericus, Vectomax CG®, a formulated combination of Bti and L. sphaericus, and diflubenzuron. In addition to the larvicides, the Swiss-Italian Ae. albopictus populations were also tested against five adulticides (bendiocarb, dichlorodiphenyltrichloroethane, malathion, permethrin and λ-cyhalothrin). Showing a similar dose-response, all mosquito populations were fully susceptible to the larvicides tested and, in particular, to Bti which is currently used both in Brazil and Switzerland. In addition, there were no signs of incipient resistance against Bti as larvae were equally susceptible to the individual toxins, Cry11Aa and Cry4Ba. The field-caught Swiss-Italian populations were susceptible to the adulticides tested but DDT mortality rates showed signs of reduced susceptibility. The insecticides currently used for

  2. Magnetic Susceptibility of liquid Gd-NM (NM = Cu, Ga, Ge alloys

    Directory of Open Access Journals (Sweden)

    Shimakura Hironori

    2017-01-01

    Full Text Available For rare earth alloys, the indirect interaction of RKKY is at work between rare-earth atoms. Therefore, the magnetism of them depends on the number of conduction electrons and the distance between rare-earth metals. In this work, to reveal the relationship between the number of conduction electrons and magnetic property of rare earth metal alloys, magnetic susceptibility measurements for liquid Gd-NM (NM = Cu, Ga, Ge was performed by Faraday method. As the results, it was observed that the sign of paramagnetic Curie temperature of Cu-Gd alloys are positive at all composition, while Ga-Gd and Ge-Gd alloys show negative paramagnetic Curie temperature at certain composition. Moreover, it was indicated when the alloy at certain composition shows highest melting temperature, it has the lowest paramagnetic Curie temperature.

  3. Genetic susceptibility to lead poisoning—A case report

    OpenAIRE

    Bijoor, Anita R.; Venkatesh, T.

    2007-01-01

    Lead poisoning is well documented in persons occupationally exposed to lead. What is less known is, that even in persons working in lead based industries, the effect of lead and the appearance of signs and symptoms of lead poisoning is genetically determined. Three genes related to lead metabolism, exhibiting polymorphism have already been demonstrated-δALA-dehydratase, Vitamin D receptor gene and Hemochromatosis gene. These alleles determine the susceptibility of the individuals to lead. We ...

  4. Bilateral Schwartze Sign, Decision-Making for Surgery

    Directory of Open Access Journals (Sweden)

    Morteza Nourollahian

    2013-10-01

    Full Text Available Otosclerosis is an otic capsule disorder that leads to progressive conductive and/or sensorineural hearing loss due to stapes footplate fixation and cochlear bone involvement. The disorder is bilateral in 70% of patients and it usually starts between the third and fifth decade. One of its characteristic clinical findings is Schwartze sign which refers to a reddish discoloration over the promontory seen beyond the intact tympanic membrane. Schwartze sign, also known as Flemingo's flush sign or Rising sun sign is believed to be associated with otospongiosis which is the active phase of the disease. The prevalence of Schwartze sign is estimated to be 10%. The prevalence of bilateral sign has not been reported, but it is presumed to be too low. Herein, we introduce a patient with bilateral positive Schwartze sign. A twenty two year old woman with bilateral hearing loss came to our clinic. She also complained from non pulsating tinnitus in both ears since one year ago. On physical examination, bilateral schwartze sign with an intact tympanic membrane was noted (Fig.1.  The audiometric evaluation showed a conductive hearing loss with speech reception threshold of 50 dB and 30 dB for the right and left ear respectively. Sodium fluoride 8mg every 8 hours was prescribed for three months. She noticed partial improvement during the treatment and on her otoscopic exam, the Schwartze sign was reduced. Then stapedotomy was scheduled for the right ear (the worse ear in regard to     the hearing & tinnitus. The surgery went uneventful and she proved to be much better afterwards. Her right ear tinnistus has gone completely and the speech reception threshold has changed from 45 dB preoperatively to 10 dB postoperatively. It seems that the surgery remains a therapeutic option, when the active phase of the disease is stabilized even following a short course of pharmacologic therapy.

  5. The morbidly adherent placenta: when and what association of signs can improve MRI diagnosis? Our experience.

    Science.gov (United States)

    Valentini, Anna Lia; Gui, Benedetta; Ninivaggi, Valeria; Miccò, Maura; Giuliani, Michela; Russo, Luca; Marini, Maria Giulia; Tintoni, Mauro; Cavaliere, Anna Franca; Bonomo, Lorenzo

    2017-01-01

    We aimed to verify whether combination of specific signs improves magnetic resonance imaging (MRI) accuracy in morbidly adherent placenta (MAP). MRI findings for MAP were retrospectively evaluated in 27 women. Histopathology was the reference standard, showing MAP in eight of 27 cases. Specificity, sensitivity, positive predictive value, and negative predictive value were calculated for all MRI signs. Two skilled radiologists analyzed MRI findings, resolving discrepancies by consensus, using three alternative diagnostic criteria during three consecutive sections. First criterion: at least one of reported MRI signs indicates MAP and the absence of any sign is normal; second criterion: at least one statistically significant sign indicates MAP and no sign or nonsignificant sign is normal; third criterion: at least two statistically significant signs indicate MAP and no sign, nonsignificant sign, or only one significant sign is normal. Using the first criterion yielded an unacceptable rate of false positive results (78.9%). Using the second criterion there were less false positive results (31.5%), and diagnostic accuracy of the second criterion was significantly higher than the first; the third criterion correctly classified 100% of cases. Only specific MRI signs can correctly predict MAP at histopathology, particularly when multiple (at least two) specific signs are observed together.

  6. Exploring the Ancestral Roots of American Sign Language: Lexical Borrowing from Cistercian Sign Language and French Sign Language

    Science.gov (United States)

    Cagle, Keith Martin

    2010-01-01

    American Sign Language (ASL) is the natural and preferred language of the Deaf community in both the United States and Canada. Woodward (1978) estimated that approximately 60% of the ASL lexicon is derived from early 19th century French Sign Language, which is known as "langue des signes francaise" (LSF). The lexicon of LSF and ASL may…

  7. Comparison of Spot Sign, Blend Sign and Black Hole Sign for Outcome Prediction in Patients with Intracerebral Hemorrhage.

    Science.gov (United States)

    Sporns, Peter B; Schwake, Michael; Kemmling, André; Minnerup, Jens; Schwindt, Wolfram; Niederstadt, Thomas; Schmidt, Rene; Hanning, Uta

    2017-09-01

    Blend sign (BS) and black hole sign (BHS) on non-contrast computed tomography (NCCT) and spot sign (SS) on CT-angiography (CTA) are indicators of early hematoma expansion in spontaneous intracerebral hemorrhage (ICH). However, their independent contributions to outcome have not been well explored. In this retrospective study, inclusion criteria were: 1) spontaneous ICH and 2) NCCT and CTA performed on admission within 6 hours after onset of symptoms. Discharge outcome was dichotomized as good (modified Rankin Scale [mRS] 0-3) and poor (mRS 4-6) outcomes. The impacts of BHS, BS and SS on outcome were assessed in univariate and multivariable logistic regression models. Of 182 patients with spontaneous ICH, 26 (14.3%) presented with BHS, 37 (20.3%) with BS and 39 (21.4%) with SS. There was a substantial correlation between SS and BS (κ=0.701) and a moderate correlation between SS and BHS (κ=0.424). In univariable logistic regression, higher baseline hematoma volume (P<0.001), intraventricular hemorrhage (P=0.002) and the presence of BHS/BS/SS (all P<0.001) on admission CT scan were associated with poor outcome. Multivariable analysis identified intraventricular haemorrhage (odds ratio [OR] 2.22 per mL, P=0.022), baseline hematoma volume (OR 1.03 per mL, P<0.001) and SS on CTA (OR 11.43, P<0.001) as independent predictors of poor outcome, showing that SS compared to BS and BHS was more powerful to predict poor outcome. The NCCT BHS and BS are correlated with the CTA SS and are reliable predictors of poor outcome in patients with ICH. Of the CT variables indicating early hematoma expansion, SS on CTA was the most reliable outcome predictor. However, given their correlation with SS on CTA, BS and BHS on NCCT can be useful for predicting outcome if CTA is not obtainable.

  8. Pathogen recognition by DC-SIGN shapes adaptive immunity.

    Science.gov (United States)

    Geijtenbeek, Teunis B H; den Dunnen, Jeroen; Gringhuis, Sonja I

    2009-09-01

    Dendritic cells (DCs) tailor adaptive immune responses to specific pathogens. This diversity is mediated by cooperation between different pattern recognition receptors that are triggered by specific pathogens. DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is a pattern recognition receptor with a broad pathogen recognition specificity as a result of its affinity for mannose and fucose carbohydrates. DC-SIGN induces very diverse immune responses to different pathogens, such as bacteria, fungi, helminths and viruses. Recent data show that DC-SIGN triggering by pathogens modulates Toll-like receptor signaling at the level of nuclear factor-kappaB. In this article, we will discuss the signaling pathways induced by DC-SIGN and its central role in the regulation of adaptive immunity to bacterial, fungal and viral pathogens.

  9. Sign problem and Monte Carlo calculations beyond Lefschetz thimbles

    Energy Technology Data Exchange (ETDEWEB)

    Alexandru, Andrei [Department of Physics, The George Washington University,Washington, DC 20052 (United States); Başar, Gökçe; Bedaque, Paulo F.; Ridgway, Gregory W.; Warrington, Neill C. [Department of Physics, University of Maryland,College Park, MD 20742 (United States)

    2016-05-10

    We point out that Monte Carlo simulations of theories with severe sign problems can be profitably performed over manifolds in complex space different from the one with fixed imaginary part of the action (“Lefschetz thimble”). We describe a family of such manifolds that interpolate between the tangent space at one critical point (where the sign problem is milder compared to the real plane but in some cases still severe) and the union of relevant thimbles (where the sign problem is mild but a multimodal distribution function complicates the Monte Carlo sampling). We exemplify this approach using a simple 0+1 dimensional fermion model previously used on sign problem studies and show that it can solve the model for some parameter values where a solution using Lefschetz thimbles was elusive.

  10. Sign problem and Monte Carlo calculations beyond Lefschetz thimbles

    CERN Document Server

    Alexandru, Andrei; Bedaque, Paulo F; Ridgway, Gregory W; Warrington, Neill C

    2015-01-01

    We point out that Monte Carlo simulations of theories with severe sign problems can be profitably performed over manifolds in complex space different from the one with fixed imaginary part of the action. We describe a family of such manifolds that interpolate between the tangent space at one critical point, where the sign problem is milder compared to the real plane but in some cases still severe, and the union of relevant thimbles, where the sign problem is mild but a multimodal distribution function complicates the Monte Carlo sampling. We exemplify this approach using a simple 0 + 1 dimensional fermion model previously used on sign problem studies and show that it can solve the model for some parameter values where a solution using Lefshetz thimbles was elusive.

  11. Linear sign in cystic brain lesions ≥5 mm. A suggestive feature of perivascular space

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Jinkyeong [The Catholic University of Korea, Department of Radiology, Seoul St. Mary' s Hospital, College of Medicine, Seoul (Korea, Republic of); The Catholic University of Korea, Department of Radiology, St. Vincent' s Hospital, College of Medicine, Seoul (Korea, Republic of); Jang, Jinhee; Choi, Hyun Seok; Jung, So-Lyung; Ahn, Kook-Jin; Kim, Bum-soo [The Catholic University of Korea, Department of Radiology, Seoul St. Mary' s Hospital, College of Medicine, Seoul (Korea, Republic of)

    2017-11-15

    To determine the prevalence of a linear sign within enlarged perivascular space (EPVS) and chronic lacunar infarction (CLI) ≥ 5 mm on T2-weighted imaging (T2WI) and time-of-flight (TOF) magnetic resonance angiography (MRA), and to evaluate the diagnostic value of the linear signs for EPVS over CLI. This study included 101 patients with cystic lesions ≥ 5 mm on brain MRI including TOF MRA. After classification of cystic lesions into EPVS or CLI, two readers assessed linear signs on T2WI and TOF MRA. We compared the prevalence and the diagnostic performance of linear signs. Among 46 EPVS and 51 CLI, 84 lesions (86.6%) were in basal ganglia. The prevalence of T2 and TOF linear signs was significantly higher in the EPVS than in the CLI (P <.001). For the diagnosis of EPVS, T2 and TOF linear signs showed high sensitivity (> 80%). TOF linear sign showed significantly higher specificity (100%) and accuracy (92.8% and 90.7%) than T2 linear sign (P <.001). T2 and TOF linear signs were more frequently observed in EPVS than CLI. They showed high sensitivity in differentiation of them, especially for basal ganglia. TOF sign showed higher specificity and accuracy than T2 sign. (orig.)

  12. Vital Signs-Trucker Safety

    Centers for Disease Control (CDC) Podcasts

    2015-03-03

    This podcast is based on the March 2015 CDC Vital Signs report. In 2012 in the United States, about 317,000 motor vehicle crashes involved a large truck. Twenty-six thousand truck drivers and their passengers were injured in these crashes, and about 700 died. Learn what can be done to help truck drivers stay safe.  Created: 3/3/2015 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 3/3/2015.

  13. Writing Signed Languages: What For? What Form?

    Science.gov (United States)

    Grushkin, Donald A

    2017-01-01

    Signed languages around the world have tended to maintain an "oral," unwritten status. Despite the advantages of possessing a written form of their language, signed language communities typically resist and reject attempts to create such written forms. The present article addresses many of the arguments against written forms of signed languages, and presents the potential advantages of writing signed languages. Following a history of the development of writing in spoken as well as signed language populations, the effects of orthographic types upon literacy and biliteracy are explored. Attempts at writing signed languages have followed two primary paths: "alphabetic" and "icono-graphic." It is argued that for greatest congruency and ease in developing biliteracy strategies in societies where an alphabetic script is used for the spoken language, signed language communities within these societies are best served by adoption of an alphabetic script for writing their signed language.

  14. Signs and Symptoms of Mood Disorders

    Science.gov (United States)

    ... Announcements Partnering with DBSA Signs and Symptoms of Mood Disorders Depression and bipolar disorder (also known as manic ... learn more about the signs and symptoms of mood disorders so that you can get the help you ...

  15. CDC Vital Signs: Prescription Painkiller Overdoses (Opioids)

    Science.gov (United States)

    ... tests for people using prescription painkillers long term. Teaching patients how to safely use, store, and dispose ... 0:60 seconds] Vital Signs – Prescription Painkiller Overdoses [SPANISH PODCAST – 1:30 minutes] Vital Signs: Prescription Painkiller ...

  16. Signs and Symptoms of Untreated Lyme Disease

    Science.gov (United States)

    ... Lyme disease FAQ Health care providers Educational materials Signs and Symptoms of Untreated Lyme Disease Recommend on ... to an area where Lyme disease occurs . Early Signs and Symptoms (3 to 30 days after tick ...

  17. Derivative Sign Patterns in Two Dimensions

    Science.gov (United States)

    Schilling, Kenneth

    2013-01-01

    Given a function defined on a subset of the plane whose partial derivatives never change sign, the signs of the partial derivatives form a two-dimensional pattern. We explore what patterns are possible for various planar domains.

  18. 23 CFR 750.707 - Nonconforming signs.

    Science.gov (United States)

    2010-04-01

    ... permitted by State law and reerected in kind, exception may be made for signs destroyed due to vandalism and... percentage of its replacement cost may be considered destroyed. (ii) Where an existing nonconforming sign...

  19. 12 CFR 328.1 - Official sign.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Official sign. 328.1 Section 328.1 Banks and... OF MEMBERSHIP § 328.1 Official sign. (a) The official sign referred to in this part shall be 7″ by 3... “symbol” of the Corporation, as used in this part, shall be that portion of the official sign consisting...

  20. [Danger signs in the malaria patient].

    Science.gov (United States)

    Tobón, Alberto

    2009-06-01

    Danger signs are clinical indicators of severity and are useful to predict complications or death. In the malaria patient, clinical or parasitological signs can be easily be recognized during the acute phase of the illness that indicate serious complications. Danger signs include neurological change, abnormal breathing pattern, persistent vomiting and diarrhea, jaundice, bleeding, dark urine, delayed capillary refill, intense pallor, hyperpyrexia, hyperparasitemia and schizontemia. Timely recognition of these signs can lead to a decrease in cases with complications and deaths.

  1. TRAFFIC SIGN RECOGNATION WITH VIDEO PROCESSING TECHNIQUE

    Directory of Open Access Journals (Sweden)

    Musa AYDIN

    2013-01-01

    Full Text Available In this study, traffic signs are aimed to be recognized and identified from a video image which is taken through a video camera. To accomplish our aim, a traffic sign recognition program has been developed in MATLAB/Simulink environment. The target traffic sign are recognized in the video image with the developed program.

  2. Sign Language Conversational Interaction between Chimpanzees.

    Science.gov (United States)

    Fouts, Roger S.; And Others

    1984-01-01

    Systematic sampling was done of signing between five home-reared chimpanzees who had had 4-7 years of complete immersion in integrating their signing interaction into their nonverbal communication. Eight-eight percent of all signs reported fell into the social categories of reassurance, social interaction, and play. (SL)

  3. 14 CFR 406.111 - Signing documents.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Signing documents. 406.111 Section 406.111... Transportation Adjudications § 406.111 Signing documents. (a) Signature required. The party, or the party's attorney or representative, must sign each document tendered for filing or served on each party. (b) Effect...

  4. Moving Speech: The Artistry of Sign Language.

    Science.gov (United States)

    Masse, Marguerite

    1996-01-01

    States that ASL (American Sign Language) has recently gained the interest of theater educators as a teaching tool, and that Gallaudet University is the leader in deaf theater education. Discusses sign language interpreting for the theater as a growing field. Explores programs in the New York School for the Deaf and the Cleveland SignStage. (PA)

  5. 15 CFR 265.14 - Signs.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Signs. 265.14 Section 265.14 Commerce..., MARYLAND, AND BOULDER AND FORT COLLINS, COLORADO Traffic and Vehicular Regulations § 265.14 Signs. Every driver shall comply with all posted traffic and parking signs. ...

  6. 32 CFR 263.8 - Signs.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Signs. 263.8 Section 263.8 National Defense... VEHICLE CONTROL ON CERTAIN DEFENSE MAPPING AGENCY SITES § 263.8 Signs. Every driver shall comply with all posted traffic signs. ...

  7. 30 CFR 57.12021 - Danger signs.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Danger signs. 57.12021 Section 57.12021 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Underground § 57.12021 Danger signs. Suitable danger signs shall be posted at all major electrical...

  8. 30 CFR 56.12021 - Danger signs.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Danger signs. 56.12021 Section 56.12021 Mineral... HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity § 56.12021 Danger signs. Suitable danger signs shall be posted at all major electrical installations. ...

  9. 30 CFR 56.4101 - Warning signs.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Warning signs. 56.4101 Section 56.4101 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Prohibitions/precautions/housekeeping § 56.4101 Warning signs. Readily visible signs prohibiting smoking and...

  10. 49 CFR 234.245 - Signs.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Signs. 234.245 Section 234.245 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF... Maintenance Standards § 234.245 Signs. Each sign mounted on a highway-rail grade crossing signal post shall be...

  11. 30 CFR 57.4101 - Warning signs.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Warning signs. 57.4101 Section 57.4101 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Prohibitions/precautions/housekeeping § 57.4101 Warning signs. Readily visible signs prohibiting smoking and...

  12. 10 CFR 20.1901 - Caution signs.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Caution signs. 20.1901 Section 20.1901 Energy NUCLEAR... signs. (a) Standard radiation symbol. Unless otherwise authorized by the Commission, the symbol... and without a color requirement. (c) Additional information on signs and labels. In addition to the...

  13. 27 CFR 6.102 - Outside signs.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Outside signs. 6.102... OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.102 Outside signs. The act by an industry member of giving or selling outside signs to a retailer does not constitute a means to induce within the...

  14. 27 CFR 44.141 - Sign.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Sign. 44.141 Section 44... PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Operations by Export Warehouse Proprietors § 44.141 Sign. Every... is located, or at the entrance of his warehouse, where it can be plainly seen, a sign, in plain and...

  15. Lexicography and Sign Language Engineering: The Zambian ...

    African Journals Online (AJOL)

    special linguistic needs because of the very nature of sign language. In Zambia, like in the vast majority of other Third World countries, the linguistic needs of deaf and hard-of-hearing people have been ignored. This article examines the genesis and implementation of a dictionary project for sign Ianguage, the Zambian Sign ...

  16. The Legal Recognition of Sign Languages

    Science.gov (United States)

    De Meulder, Maartje

    2015-01-01

    This article provides an analytical overview of the different types of explicit legal recognition of sign languages. Five categories are distinguished: constitutional recognition, recognition by means of general language legislation, recognition by means of a sign language law or act, recognition by means of a sign language law or act including…

  17. Sign Language Planning: Pragmatism, Pessimism and Principles

    Science.gov (United States)

    Turner, Graham H.

    2009-01-01

    This article introduces the present collection of sign language planning studies. Contextualising the analyses against the backdrop of core issues in the theory of language planning and the evolution of applied sign linguistics, it is argued that--while the sociolinguistic circumstances of signed languages worldwide can, in many respects, be…

  18. Research on the Translation of Public Signs

    Science.gov (United States)

    Qiannan, Ma

    2012-01-01

    Because of the increasing international image of China, the translation of public signs in city has become the very important issue. From the point of view of cross-cultural communication, the public signs have crucial influence on the image of the city, even for the whole China. However, there exist many translation errors of the public signs in…

  19. Magnetic susceptibilities of minerals

    Science.gov (United States)

    Rosenblum, Sam; Brownfield, I.K.

    2000-01-01

    Magnetic separation of minerals is a topic that is seldom reported in the literature for two reasons. First, separation data generally are byproducts of other projects; and second, this study requires a large amount of patience and is unusually tedious. Indeed, we suspect that most minerals probably are never investigated for this property. These data are timesaving for mineralogists who concentrate mono-mineralic fractions for chemical analysis, age dating, and for other purposes. The data can certainly be used in the ore-beneficiation industries. In some instances, magnetic-susceptibility data may help in mineral identification, where other information is insufficient. In past studies of magnetic separation of minerals, (Gaudin and Spedden, 1943; Tille and Kirkpatrick, 1956; Rosenblum, 1958; Rubinstein and others, 1958; Flinter, 1959; Hess, 1959; Baker, 1962; Meric and Peyre, 1963; Rojas and others, 1965; and Duchesne, 1966), the emphasis has been on the ferromagnetic and paramagnetic ranges of extraction. For readers interested in the history of magnetic separation of minerals, Krumbein and Pettijohn (1938, p. 344-346) indicated nine references back to 1848. The primary purpose of this paper is to report the magnetic-susceptibility data on as many minerals as possible, similar to tables of hardness, specific gravity, refractive indices, and other basic physical properties of minerals. A secondary purpose is to demonstrate that the total and best extraction ranges are influenced by the chemistry of the minerals. The following notes are offered to help avoid problems in separating a desired mineral concentrate from mixtures of mineral grains.

  20. Alcohol increases hypnotic susceptibility.

    Science.gov (United States)

    Semmens-Wheeler, Rebecca; Dienes, Zoltán; Duka, Theodora

    2013-09-01

    One approach to hypnosis suggests that for hypnotic experience to occur frontal lobe activity must be attenuated. For example, cold control theory posits that a lack of awareness of intentions is responsible for the experience of involuntariness and/or the subjective reality of hypnotic suggestions. The mid-dorso-lateral prefrontal cortex and the ACC are candidate regions for such awareness. Alcohol impairs frontal lobe executive function. This study examined whether alcohol affects hypnotisability. We administered 0.8 mg/kg of alcohol or a placebo to 32 medium susceptible participants. They were subsequently hypnotised and given hypnotic suggestions. All participants believed they had received some alcohol. Participants in the alcohol condition were more susceptible to hypnotic suggestions than participants in the placebo condition. Impaired frontal lobe activity facilitates hypnotic responding, which supports theories postulating that attenuation of executive function facilitates hypnotic response, and contradicts theories postulating that hypnotic response involves enhanced inhibitory, attentional or other executive function. Copyright © 2013. Published by Elsevier Inc.

  1. Diagnostic Value of Direct Antibiotic Susceptibility Test for Faster BacterialSusceptibility Reporting in Bacteremia

    Directory of Open Access Journals (Sweden)

    Rebriarina Hapsari

    2012-12-01

    Methods: Bloods from positive BACTEC bottles which met inclusion and exclusion criteria were put into sterile tubes and centrifuged. The pellets were then used to make 0.5 McFarland bacterial suspensions and directly used for antibiotic susceptibility testing. Interpretations of direct method were compared to standard method to count sensitivity, specificity, sensitive predictive value, resistant predictive value, accuracy, and kappa value. Results: From 58 samples (containing 22 gram negative, 36 gram positive bacteria, there were 309 total antibiotic susceptibility tests. Direct method showed sensitivity, specificity, sensitive predictive value, resistant predictive value, accuracy, and kappa value of 89.3%, 92.9%, 93.8%, 87.8%, 86.4%, and 0.82, respectively. Conclusion: Direct antibiotic susceptibility testing has a good agreement with the standard method so it can aid faster antibiotic susceptibility reporting in bacteraemia (Sains Medika, 4(2:174-181.

  2. Corals hosting symbiotic hydrozoans are less susceptible to predation and disease

    KAUST Repository

    Montano, Simone

    2017-12-20

    In spite of growing evidence that climate change may dramatically affect networks of interacting species, whether-and to what extent-ecological interactions can mediate species\\' responses to disturbances is an open question. Here we show how a largely overseen association such as that between hydrozoans and scleractinian corals could be possibly associated with a reduction in coral susceptibility to ever-increasing predator and disease outbreaks. We examined 2455 scleractinian colonies (from both Maldivian and the Saudi Arabian coral reefs) searching for non-random patterns in the occurrence of hydrozoans on corals showing signs of different health conditions (i.e. bleaching, algal overgrowth, corallivory and different coral diseases). We show that, after accounting for geographical, ecological and co-evolutionary factors, signs of disease and corallivory are significantly lower in coral colonies hosting hydrozoans than in hydrozoan-free ones. This finding has important implications for our understanding of the ecology of coral reefs, and for their conservation in the current scenario of global change, because it suggests that symbiotic hydrozoans may play an active role in protecting their scleractinian hosts from stresses induced by warming water temperatures.

  3. Geometry Dependence of the Sign Problem

    Science.gov (United States)

    Iglovikov, Vladimir; Khatami, Ehsan; Fye, Richard; Scalettar, Richard

    2015-03-01

    The sign problem is a fundamental limitation to Quantum Monte Carlo (QMC) simulations of the statistical mechanics of interacting fermions and frustrated quantum spins. We produced a comprehensive dataset on the geometry dependence of the sign problem for different densities, interaction strengths, inverse temperatures and spatial lattice sizes. We supplement this data with several observations concerning general patterns/trends in the data, including the dependence on spatial volume and how this can be probed by examining decoupled clusters, the scaling of the sign in the vicinity of a particle-hole symmetric point, and the correlation between the total sign and the signs of the individual spin up and spin down components.

  4. The sixth vital sign in diabetes.

    Science.gov (United States)

    Kalra, Sanjay; Verma, Komal; Singh Balhara, Yatan Pal

    2018-01-01

    The vital signs are an integral part of clinical methods. In diabetes, determination of plasma glucose can be taken as the fifth vital sign. The sixth vital sign is well being, which can easily be measured by two item questionnaires designed to assess distress, depression and coping skills. This sign is essential for the screening and follow up of persons living with diabetes, as it provides an idea of quality of care, helps plan therapeutic interventions, and serves as a surrogate for prognosis or outcome. Inclusion of the sixth vital sign reflects the relevance of the bio-psychosocial model of health to diabetes care. .

  5. Research on Recognition and Evaluation of Traffic Guide Sign

    Directory of Open Access Journals (Sweden)

    Li Yuan

    2015-01-01

    Full Text Available Traffic guide signs are effective only when they are clearly recognized by drivers. Three experiments were conducted in this study. In the first, the influence factors of guide sign recognition were studied. This study investigated 11 main factors with a convenience sample of drivers from Nanjing city in China. Weights of different influence factors were obtained through analytic hierarchy process (AHP. The results showed that the setting position, occlusion degree, and character size of guide sign had the most significant influence on the guide sign recognition, while other factors were less important. In the second stage, an evaluation model of guide sign recognition was developed based on weights of different factors. Four equations were presented to calculate the comprehensive score of guide sign, and the level of recognition was divided into five grades according to the comprehensive score. At last, a typical case in Nanjing was studied to verify the rationality and reliability of the evaluation model. Results from the real application indicate that the method had good applicability and can be used by traffic engineers.

  6. A model of traffic signs recognition with convolutional neural network

    Science.gov (United States)

    Hu, Haihe; Li, Yujian; Zhang, Ting; Huo, Yi; Kuang, Wenqing

    2016-10-01

    In real traffic scenes, the quality of captured images are generally low due to some factors such as lighting conditions, and occlusion on. All of these factors are challengeable for automated recognition algorithms of traffic signs. Deep learning has provided a new way to solve this kind of problems recently. The deep network can automatically learn features from a large number of data samples and obtain an excellent recognition performance. We therefore approach this task of recognition of traffic signs as a general vision problem, with few assumptions related to road signs. We propose a model of Convolutional Neural Network (CNN) and apply the model to the task of traffic signs recognition. The proposed model adopts deep CNN as the supervised learning model, directly takes the collected traffic signs image as the input, alternates the convolutional layer and subsampling layer, and automatically extracts the features for the recognition of the traffic signs images. The proposed model includes an input layer, three convolutional layers, three subsampling layers, a fully-connected layer, and an output layer. To validate the proposed model, the experiments are implemented using the public dataset of China competition of fuzzy image processing. Experimental results show that the proposed model produces a recognition accuracy of 99.01 % on the training dataset, and yield a record of 92% on the preliminary contest within the fourth best.

  7. Lexical access in sign language: A computational model

    Directory of Open Access Journals (Sweden)

    Naomi Kenney Caselli

    2014-05-01

    Full Text Available Psycholinguistic theories have predominantly been built upon data from spoken language, which leaves open the question: How many of the conclusions truly reflect language-general principles as opposed to modality-specific ones? We take a step toward answering this question in the domain of lexical access in recognition by asking whether a single cognitive architecture might explain diverse behavioral patterns in signed and spoken language. Chen and Mirman (2012 presented a computational model of word processing that unified opposite effects of neighborhood density in speech production, perception, and written word recognition. Neighborhood density effects in sign language also vary depending on whether the neighbors share the same handshape or location. We present a spreading activation architecture that borrows the principles proposed by Chen and Mirman (2012, and show that if this architecture is elaborated to incorporate relatively minor facts about either 1 the time course of sign perception or 2 the frequency of sub-lexical units in sign languages, it produces data that match the experimental findings from sign languages. This work serves as a proof of concept that a single cognitive architecture could underlie both sign and word recognition.

  8. [Babinski and Chaddock signs without apparent pyramidal disfunction].

    Science.gov (United States)

    Maranhão-Filho, Péricles; Dib, Eduardo; Ribeiro, Rodrigo Gaspar

    2005-06-01

    The main objective of this study was to verify, in one hundred in-patients from the Serviço de Clínica Médica do Hospital Universitário Clementino Fraga Filho da Universidade Federal do Rio de Janeiro who did not have a history of clinical symptoms of pyramidal disfunction, the presence of the Babinski and Chaddock signs. As a secondary objective, we looked for a prevalence of one of the signs over the other, and the influence of the head position regarding the obtained responses. The patients were examined while supine with their heads in three different positions. Out of the one hundred patients, ten of them (10%) showed hallux extension uni or bilateral. The Babinski sign was positive 18 times (40%), and the Chaddock sign was positive 27 times (60%). The Chaddock sign occurred more frequently than the Babinski sign, the abnormal reflex occurred twice as much on the left foot than the right, and apparently there was no interference regarding the head position in relation to the obtained results.

  9. Lexical access in sign language: a computational model.

    Science.gov (United States)

    Caselli, Naomi K; Cohen-Goldberg, Ariel M

    2014-01-01

    PSYCHOLINGUISTIC THEORIES HAVE PREDOMINANTLY BEEN BUILT UPON DATA FROM SPOKEN LANGUAGE, WHICH LEAVES OPEN THE QUESTION: How many of the conclusions truly reflect language-general principles as opposed to modality-specific ones? We take a step toward answering this question in the domain of lexical access in recognition by asking whether a single cognitive architecture might explain diverse behavioral patterns in signed and spoken language. Chen and Mirman (2012) presented a computational model of word processing that unified opposite effects of neighborhood density in speech production, perception, and written word recognition. Neighborhood density effects in sign language also vary depending on whether the neighbors share the same handshape or location. We present a spreading activation architecture that borrows the principles proposed by Chen and Mirman (2012), and show that if this architecture is elaborated to incorporate relatively minor facts about either (1) the time course of sign perception or (2) the frequency of sub-lexical units in sign languages, it produces data that match the experimental findings from sign languages. This work serves as a proof of concept that a single cognitive architecture could underlie both sign and word recognition.

  10. Is Lhasa Tibetan Sign Language emerging, endangered, or both?

    Science.gov (United States)

    Hofer, Theresia

    2017-05-24

    This article offers the first overview of the recent emergence of Tibetan Sign Language (TibSL) in Lhasa, capital of the Tibet Autonomous Region (TAR), China. Drawing on short anthropological fieldwork, in 2007 and 2014, with people and organisations involved in the formalisation and promotion of TibSL, the author discusses her findings within the nine-fold UNESCO model for assessing linguistic vitality and endangerment. She follows the adaptation of this model to assess signed languages by the Institute of Sign Languages and Deaf Studies (iSLanDS) at the University of Central Lancashire. The appraisal shows that TibSL appears to be between "severely" and "definitely" endangered, adding to the extant studies on the widespread phenomenon of sign language endangerment. Possible future influences and developments regarding the vitality and use of TibSL in Central Tibet and across the Tibetan plateau are then discussed and certain additions, not considered within the existing assessment model, suggested. In concluding, the article places the situation of TibSL within the wider circumstances of minority (sign) languages in China, Chinese Sign Language (CSL), and the post-2008 movement to promote and use "pure Tibetan language".

  11. Astrological birth signs in suicide: hypothesis or speculation?

    Science.gov (United States)

    Salib, Emad

    2003-04-01

    Astrology is no longer regarded as a science by many, because its claims are almost impossible to test empirically in controlled laboratory conditions and it can not meet the scientific need to be reproducible. However, the majority of those who read their 'star signs' can identify aspects of their personality in what they read and it is possible that this may influence their attitudes and actions. The literature has neglected astrological signs as a possible predictor of suicide ideation. To see whether astrological birth signs are associated with suicide and the method used, data was collected from the Public Health Department in North Cheshire representing all the Cheshire Coroner's verdicts of suicide, and open verdicts, in all deceased aged 60 and above between 1989 and 2000. The observed occurrence of deaths due to natural causes, and suicide, in relation to birth signs did not differ significantly from what would be expected from chance. However, the distribution of suicide by hanging appeared significantly higher in those with a birth sign of Virgo and lowest in Sagittarius and Scorpio. The distribution of violent and non-violent suicides in relation to star signs showed higher occurences of violent death in persons born in the summer months.

  12. Clinical signs and anatomical correlation of patellar tendinitis

    Directory of Open Access Journals (Sweden)

    Rath Ehud

    2010-01-01

    Full Text Available Background: Patellar tendinitis is one of the several differential diagnosis of anterior knee pain. The clinical diagnosis of patellar tendinitis is based on tenderness to palpation at the inferior pole of the patella. The tenderness has been noted to be maximal when the knee is extended and the quadriceps relaxed, but a definite clinical sign for diagnosis is lacking. The accuracy of two clinical signs was assesed by a two-stage study which included physical examination, MRI and a cadaveric study. Materials and Methods: Two clinical signs, the "passive flexion-extension sign" and the "standing active quadriceps sign" were assessed in 10 consecutive patients with presumed patellar tendinitis. Five patients had an MRI, showed focal abnormality in the tendon. The location of the MRI finding corresponded, to the region of maximal tenderness. A cadaveric dissection was undertaken to describe the anatomy of the patella and the patellar tendon during these tests. Results: Both tests showed a significant decrease in tenderness at the area of inflammation when the patellar tendon was under tension. The cadaveric dissection showed that when the knee is flexed to 90΀ or when the quadriceps is tensioned the deep fibers of the tendon do not deform to anteriorly applied pressure. Conclusion: We suggest using these studies routinely in the evaluation of patients with anterior knee pain.

  13. Antimicrobial susceptibility profile of Listeria species isolated from ...

    African Journals Online (AJOL)

    The antimicrobial susceptibility profile of L. monocytogenes and other Listeria species isolated from some ready-to-eat (RTE) foods sold in Kano metropolis, north-western Nigeria was carried out using disc-diffusion method. The results obtained showed that L. monocytogenes was moderately susceptible to all the ...

  14. Reduced fluoroquinolone susceptibility in Salmonella enterica isolates from travelers, Finland.

    Science.gov (United States)

    Lindgren, Marianne M; Kotilainen, Pirkko; Huovinen, Pentti; Hurme, Saija; Lukinmaa, Susanna; Webber, Mark A; Piddock, Laura J V; Siitonen, Anja; Hakanen, Antti J

    2009-05-01

    We tested the fluoroquinolone susceptibility of 499 Salmonella enterica isolates collected from travelers returning to Finland during 2003-2007. Among isolates from travelers to Thailand and Malaysia, reduced fluoroquinolone susceptibility decreased from 65% to 22% (p = 0.002). All isolates showing nonclassical quinolone resistance were from travelers to these 2 countries.

  15. Towards a Sign Language Synthesizer: a Bridge to Communication Gap of the Hearing/Speech Impaired Community

    Science.gov (United States)

    Maarif, H. A.; Akmeliawati, R.; Gunawan, T. S.; Shafie, A. A.

    2013-12-01

    Sign language synthesizer is a method to visualize the sign language movement from the spoken language. The sign language (SL) is one of means used by HSI people to communicate to normal people. But, unfortunately the number of people, including the HSI people, who are familiar with sign language is very limited. These cause difficulties in the communication between the normal people and the HSI people. The sign language is not only hand movement but also the face expression. Those two elements have complimentary aspect each other. The hand movement will show the meaning of each signing and the face expression will show the emotion of a person. Generally, Sign language synthesizer will recognize the spoken language by using speech recognition, the grammatical process will involve context free grammar, and 3D synthesizer will take part by involving recorded avatar. This paper will analyze and compare the existing techniques of developing a sign language synthesizer, which leads to IIUM Sign Language Synthesizer.

  16. Topological susceptibility from slabs

    Energy Technology Data Exchange (ETDEWEB)

    Bietenholz, Wolfgang [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, A.P. 70-543, Distrito Federal, C.P. 04510 (Mexico); Forcrand, Philippe de [Institute for Theoretical Physics, ETH Zürich,CH-8093 Zürich (Switzerland); CERN, Physics Department, TH Unit, CH-1211 Geneva 23 (Switzerland); Gerber, Urs [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, A.P. 70-543, Distrito Federal, C.P. 04510 (Mexico); Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo,Edificio C-3, Apdo. Postal 2-82, Morelia, Michoacán, C.P. 58040 (Mexico)

    2015-12-14

    In quantum field theories with topological sectors, a non-perturbative quantity of interest is the topological susceptibility χ{sub t}. In principle it seems straightforward to measure χ{sub t} by means of Monte Carlo simulations. However, for local update algorithms and fine lattice spacings, this tends to be difficult, since the Monte Carlo history rarely changes the topological sector. Here we test a method to measure χ{sub t} even if data from only one sector are available. It is based on the topological charges in sub-volumes, which we denote as slabs. Assuming a Gaussian distribution of these charges, this method enables the evaluation of χ{sub t}, as we demonstrate with numerical results for non-linear σ-models.

  17. Topological Susceptibility from Slabs

    CERN Document Server

    Bietenholz, Wolfgang; Gerber, Urs

    2015-01-01

    In quantum field theories with topological sectors, a non-perturbative quantity of interest is the topological susceptibility chi_t. In principle it seems straightforward to measure chi_t by means of Monte Carlo simulations. However, for local update algorithms and fine lattice spacings, this tends to be difficult, since the Monte Carlo history rarely changes the topological sector. Here we test a method to measure chi_t even if data from only one sector are available. It is based on the topological charges in sub-volumes, which we denote as slabs. Assuming a Gaussian distribution of these charges, this method enables the evaluation of chi_t, as we demonstrate with numerical results for non-linear sigma-models.

  18. A sign-component-based framework for Chinese sign language recognition using accelerometer and sEMG data.

    Science.gov (United States)

    Li, Yun; Chen, Xiang; Zhang, Xu; Wang, Kongqiao; Wang, Z Jane

    2012-10-01

    Identification of constituent components of each sign gesture can be beneficial to the improved performance of sign language recognition (SLR), especially for large-vocabulary SLR systems. Aiming at developing such a system using portable accelerometer (ACC) and surface electromyographic (sEMG) sensors, we propose a framework for automatic Chinese SLR at the component level. In the proposed framework, data segmentation, as an important preprocessing operation, is performed to divide a continuous sign language sentence into subword segments. Based on the features extracted from ACC and sEMG data, three basic components of sign subwords, namely the hand shape, orientation, and movement, are further modeled and the corresponding component classifiers are learned. At the decision level, a sequence of subwords can be recognized by fusing the likelihoods at the component level. The overall classification accuracy of 96.5% for a vocabulary of 120 signs and 86.7% for 200 sentences demonstrate the feasibility of interpreting sign components from ACC and sEMG data and clearly show the superior recognition performance of the proposed method when compared with the previous SLR method at the subword level. The proposed method seems promising for implementing large-vocabulary portable SLR systems.

  19. Comparison of Swirl Sign and Black Hole Sign in Predicting Early Hematoma Growth in Patients with Spontaneous Intracerebral Hemorrhage.

    Science.gov (United States)

    Xiong, Xin; Li, Qi; Yang, Wen-Song; Wei, Xiao; Hu, Xi; Wang, Xing-Chen; Zhu, Dan; Li, Rui; Cao, Du; Xie, Peng

    2018-01-29

    BACKGROUND Early hematoma growth is associated with poor outcome in patients with spontaneous intracerebral hemorrhage (ICH). The swirl sign (SS) and the black hole sign (BHS) are imaging markers in ICH patients. The aim of this study was to compare the predictive value of these 2 signs for early hematoma growth. MATERIAL AND METHODS ICH patients were screened for the appearance of the 2 signs within 6 h after onset of symptoms. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the 2 signs in predicting early hematoma growth were assessed. The accuracy of the 2 signs in predicting early hematoma growth was analyzed by receiver-operator analysis. RESULTS A total of 200 patients were enrolled in this study. BHS was found in 30 (15%) patients, and SS was found in 70 (35%) patients. Of the 71 patients with early hematoma growth, BHS was found on initial computed tomography scans in 24 (33.8%) and SS in 33 (46.5%). The sensitivity, specificity, PPV, and NPV of BHS for predicting early hematoma growth were 33.8%, 95.3%, 80.0%, and 72.0%, respectively. The sensitivity, specificity, PPV, and NPV of SS were 46.5%, 71.3%, 47.0%, and 71.0%, respectively. The area under the curve was 0.646 for BHS and 0.589 for SS (P=0.08). Multivariate logistic regression showed that presence of BHS is an independent predictor of early hematoma growth. CONCLUSIONS The Black hole sign seems to be good predictor for hematoma growth. The presence of swirl sign on admission CT does not independently predict hematoma growth in patients with ICH.

  20. Link Label Prediction in Signed Citation Network

    KAUST Repository

    Akujuobi, Uchenna

    2016-04-12

    Link label prediction is the problem of predicting the missing labels or signs of all the unlabeled edges in a network. For signed networks, these labels can either be positive or negative. In recent years, different algorithms have been proposed such as using regression, trust propagation and matrix factorization. These approaches have tried to solve the problem of link label prediction by using ideas from social theories, where most of them predict a single missing label given that labels of other edges are known. However, in most real-world social graphs, the number of labeled edges is usually less than that of unlabeled edges. Therefore, predicting a single edge label at a time would require multiple runs and is more computationally demanding. In this thesis, we look at link label prediction problem on a signed citation network with missing edge labels. Our citation network consists of papers from three major machine learning and data mining conferences together with their references, and edges showing the relationship between them. An edge in our network is labeled either positive (dataset relevant) if the reference is based on the dataset used in the paper or negative otherwise. We present three approaches to predict the missing labels. The first approach converts the label prediction problem into a standard classification problem. We then, generate a set of features for each edge and then adopt Support Vector Machines in solving the classification problem. For the second approach, we formalize the graph such that the edges are represented as nodes with links showing similarities between them. We then adopt a label propagation method to propagate the labels on known nodes to those with unknown labels. In the third approach, we adopt a PageRank approach where we rank the nodes according to the number of incoming positive and negative edges, after which we set a threshold. Based on the ranks, we can infer an edge would be positive if it goes a node above the

  1. [CW bio-radar vital sign detector and experiment study].

    Science.gov (United States)

    Hu, Wei; Wang, Yunfeng; Zhao, Zhangyan; Zhang, Haiying

    2014-03-01

    Non-contact vital sign detection technique provides an effective usage in health monitoring applications. A vital sign detector was designed based on microwave bio-radar technique. Using Doppler principle, continuous wave bioradar was designed for tiny body movement detection, short-time Fourier transform and interpolation algorithm were adopted for heart and respiration rate extraction, embedded system was used for system integration, real-time signal processing software was designed on it. Experiments were done by using simulation device and human body for research and performance evaluation. The result shows that the proposed prototype can be used for single target vital signs detection at the distance of 90 cm, and the heart rate result shows a 96% recognition rate.

  2. Fast Traffic Sign Recognition with a Rotation Invariant Binary Pattern Based Feature

    Directory of Open Access Journals (Sweden)

    Shouyi Yin

    2015-01-01

    Full Text Available Robust and fast traffic sign recognition is very important but difficult for safe driving assistance systems. This study addresses fast and robust traffic sign recognition to enhance driving safety. The proposed method includes three stages. First, a typical Hough transformation is adopted to implement coarse-grained location of the candidate regions of traffic signs. Second, a RIBP (Rotation Invariant Binary Pattern based feature in the affine and Gaussian space is proposed to reduce the time of traffic sign detection and achieve robust traffic sign detection in terms of scale, rotation, and illumination. Third, the techniques of ANN (Artificial Neutral Network based feature dimension reduction and classification are designed to reduce the traffic sign recognition time. Compared with the current work, the experimental results in the public datasets show that this work achieves robustness in traffic sign recognition with comparable recognition accuracy and faster processing speed, including training speed and recognition speed.

  3. Fast traffic sign recognition with a rotation invariant binary pattern based feature.

    Science.gov (United States)

    Yin, Shouyi; Ouyang, Peng; Liu, Leibo; Guo, Yike; Wei, Shaojun

    2015-01-19

    Robust and fast traffic sign recognition is very important but difficult for safe driving assistance systems. This study addresses fast and robust traffic sign recognition to enhance driving safety. The proposed method includes three stages. First, a typical Hough transformation is adopted to implement coarse-grained location of the candidate regions of traffic signs. Second, a RIBP (Rotation Invariant Binary Pattern) based feature in the affine and Gaussian space is proposed to reduce the time of traffic sign detection and achieve robust traffic sign detection in terms of scale, rotation, and illumination. Third, the techniques of ANN (Artificial Neutral Network) based feature dimension reduction and classification are designed to reduce the traffic sign recognition time. Compared with the current work, the experimental results in the public datasets show that this work achieves robustness in traffic sign recognition with comparable recognition accuracy and faster processing speed, including training speed and recognition speed.

  4. Modeling the Separating Pedestrian Flow in T-Shaped Passage Based on Guide Sign

    Directory of Open Access Journals (Sweden)

    Hong-fei Jia

    2016-01-01

    Full Text Available Considering the actual situation of separating pedestrian flow in T-shaped passage, the guide sign is set to guide the pedestrians and subconscious strength is introduced to show the effect of guide sign. Pedestrian subconscious strength model is established, and the subconscious strength calculation result is added to the pedestrian simulation model which is based on cellular automata. On the platform of MATLAB software, separating pedestrian flow simulation with the effect of guide sign is realized. Simulations indicate that, compared with the separating pedestrian flow without guide sign, the efficiency of pedestrians passing with guide sign is higher. Analyzing the effect of guide sign in different positions, the suitable position of guide sign is obtained.

  5. Relationships between spoken word and sign processing in children with cochlear implants.

    Science.gov (United States)

    Giezen, Marcel R; Baker, Anne E; Escudero, Paola

    2014-01-01

    The effect of using signed communication on the spoken language development of deaf children with a cochlear implant (CI) is much debated. We report on two studies that investigated relationships between spoken word and sign processing in children with a CI who are exposed to signs in addition to spoken language. Study 1 assessed rapid word and sign learning in 13 children with a CI and found that performance in both language modalities correlated positively. Study 2 tested the effects of using sign-supported speech on spoken word processing in eight children with a CI, showing that simultaneously perceiving signs and spoken words does not negatively impact their spoken word recognition or learning. Together, these two studies suggest that sign exposure does not necessarily have a negative effect on speech processing in some children with a CI.

  6. Antimicrobial Susceptibility Patterns of Enterococcus faecalis and Enterococcus faecium Isolated from Poultry Flocks in Germany.

    Science.gov (United States)

    Maasjost, J; Mühldorfer, K; Cortez de Jäckel S; Hafez, H M

    2015-03-01

    Between 2010 and 2011, 145 Enterococcus isolates (Enterococcus faecalis, n = 127; Enterococcus faecium, n = 18) were collected during routine bacteriologic diagnostics from broilers, layers, and fattening turkeys in Germany showing various clinical signs. The susceptibility to 24 antimicrobial agents was investigated by broth microdilution test to determine minimum inhibitory concentrations (MICs). All E. faecalis isolates (n = 127) were susceptible to the beta-lactam antibiotics ampicillin, amoxicillin-clavulanic acid, and penicillin. Corresponding MIC with 50% inhibition (MIC50) and MIC with 90% inhibition (MIC90) values of these antimicrobial agents were at the lower end of the test range (≤ 4 μg/ml). In addition, no vancomycin-resistant enterococci (VRE) were found. High resistance rates were identified in both Enterococcus species for lincomycin (72%-99%) and tetracycline (67%-82%). Half or more than half of Enterococcus isolates were resistant to gentamicin (54%-72%) and the macrolide antibiotics erythromycin (44%-61%) and tylosin-tartate (44%-56%). Enterococcus faecalis isolated from fattening turkeys showed the highest prevalence of antimicrobial resistance compared to other poultry production systems. Eighty-nine out of 145 Enterococcus isolates were resistant to three or more antimicrobial classes. Again, turkeys stood out with 42 (8 1%) multiresistant isolates. The most-frequent resistance patterns of E. faecalis were gentamicin, lincomycin, and tetracycline in all poultry production systems.

  7. The signs of life in architecture.

    Science.gov (United States)

    Gruber, Petra

    2008-06-01

    Engineers, designers and architects often look to nature for inspiration. The research on 'natural constructions' is aiming at innovation and the improvement of architectural quality. The introduction of life sciences terminology in the context of architecture delivers new perspectives towards innovation in architecture and design. The investigation is focused on the analogies between nature and architecture. Apart from other principles that are found in living nature, an interpretation of the so-called 'signs of life', which characterize living systems, in architecture is presented. Selected architectural projects that have applied specific characteristics of life, whether on purpose or not, will show the state of development in this field and open up future challenges. The survey will include famous built architecture as well as students' design programs, which were carried out under supervision of the author at the Department of Design and Building Construction at the Vienna University of Technology.

  8. From gesture to sign language: conventionalization of classifier constructions by adult hearing learners of British Sign Language.

    Science.gov (United States)

    Marshall, Chloë R; Morgan, Gary

    2015-01-01

    There has long been interest in why languages are shaped the way they are, and in the relationship between sign language and gesture. In sign languages, entity classifiers are handshapes that encode how objects move, how they are located relative to one another, and how multiple objects of the same type are distributed in space. Previous studies have shown that hearing adults who are asked to use only manual gestures to describe how objects move in space will use gestures that bear some similarities to classifiers. We investigated how accurately hearing adults, who had been learning British Sign Language (BSL) for 1-3 years, produce and comprehend classifiers in (static) locative and distributive constructions. In a production task, learners of BSL knew that they could use their hands to represent objects, but they had difficulty choosing the same, conventionalized, handshapes as native signers. They were, however, highly accurate at encoding location and orientation information. Learners therefore show the same pattern found in sign-naïve gesturers. In contrast, handshape, orientation, and location were comprehended with equal (high) accuracy, and testing a group of sign-naïve adults showed that they too were able to understand classifiers with higher than chance accuracy. We conclude that adult learners of BSL bring their visuo-spatial knowledge and gestural abilities to the tasks of understanding and producing constructions that contain entity classifiers. We speculate that investigating the time course of adult sign language acquisition might shed light on how gesture became (and, indeed, becomes) conventionalized during the genesis of sign languages. Copyright © 2014 Cognitive Science Society, Inc.

  9. Cave Cyanobacteria showing antibacterial activity

    Directory of Open Access Journals (Sweden)

    Vasiliki Lamprinou

    2015-09-01

    Full Text Available Cave Cyanobacteria - thriving in an ‘extreme’ environment with interesting species biodiversity - are supposed to be a potential source of bioactive compounds. Lipid extracts from pure cultures of two recently established Cyanobacteria from Greek caves, Toxopsis calypsus and Phormidium melanochroun, were used for antibacterial screening against human pathogenic bacteria (reference and clinical isolates. Antimicrobial Susceptibility testing for both taxa was carried out using the disc-diffusion (Kirby Bauer method, while preliminary data applying the standard broth microdilution method for the determination of the Minimal Inhibitory Concentration (MIC are given only for T. calypsus. Antibacterial activity was demonstrated against the Gram-positive clinical and reference bacteria, mostly pronounced in enterococci; no activity was observed against the Gram-negative bacteria. The above screening is the first record of antibacterial activity from lipid extracts of cave Cyanobacteria enhancing the importance of cave microbiota and the necessity for cave conservation.

  10. A tour in sign language

    CERN Document Server

    François Briard

    2016-01-01

    In early May, CERN welcomed a group of deaf children for a tour of Microcosm and a Fun with Physics demonstration.   On 4 May, around ten children from the Centre pour enfants sourds de Montbrillant (Montbrillant Centre for Deaf Children), a public school funded by the Office médico-pédagogique du canton de Genève, took a guided tour of the Microcosm exhibition and were treated to a Fun with Physics demonstration. The tour guides’ explanations were interpreted into sign language in real time by a professional interpreter who accompanied the children, and the pace and content were adapted to maximise the interaction with the children. This visit demonstrates CERN’s commitment to remaining as widely accessible as possible. To this end, most of CERN’s visit sites offer reduced-mobility access. In the past few months, CERN has also welcomed children suffering from xeroderma pigmentosum (a genetic disorder causing extreme sensiti...

  11. Does walking change the Romberg sign?

    OpenAIRE

    Findlay, Gordon F. G.; Balain, Birender; Trivedi, Jayesh M.; Jaffray, David C.

    2009-01-01

    The Romberg sign helps demonstrate loss of postural control as a result of severely compromised proprioception. There is still no standard approach to applying the Romberg test in clinical neurology and the criteria for and interpretation of an abnormal result continue to be debated. The value of this sign and its adaptation when walking was evaluated. Detailed clinical examination of 50 consecutive patients of cervical myelopathy was performed prospectively. For the walking Romberg sign, pat...

  12. An electronic dictionary of Danish Sign Language

    DEFF Research Database (Denmark)

    Kristoffersen, Jette Hedegaard; Troelsgård, Thomas

    2008-01-01

    Compiling sign language dictionaries has in the last 15 years changed from most often being simply collecting and presenting signs for a given gloss in the surrounding vocal language to being a complicated lexicographic task including all parts of linguistic analysis, i.e. phonology, phonetics......, morphology, syntax and semantics. In this presentation we will give a short overview of the Danish Sign Language dictionary project. We will further focus on lemma selection and some of the problems connected with lemmatisation....

  13. Microwave susceptibility experiments

    Energy Technology Data Exchange (ETDEWEB)

    McConaghy, C.

    1984-05-29

    In certain experimental environments, systems can be affected or damaged by microwave pulses. I have conducted tests at LLNL to understand the phenomenology of microwave susceptibility of system components and subsystem components. To date, my experiments have concentrated on bipolar transistors, similar to what might be used in discrete analog circuits, and on CMOS RAM chips, which might be used in a computer memory system. I observed a decrease in failure energies for both the transistor and the integrated curcuit as I shortened the microwave pulse width. An S band (2.86 GHz) transmit/receive (T/R) tube has also been tested both at S band and at X band (8.16 GHz). The S band pulse had limitations in rise-time from zero power, which had an effect on the amount of power that could be transmitted through the T/R tube, as much as 0.7% of the incident power passed through the tube. All tests were conducted in closed-waveguide or coax test-fixtures, in contrast to the anechoic chambers utilized by other experimenters. I have used both S band and X band Klystron generators. For very high power (greater than 1 MW), I used an additional pulse-compression cavity at S band. Other subsystem components such as an X band mixer and an X band T/R tube will be tested in the future. 8 references.

  14. Binding of HIV-1 gp120 to DC-SIGN Promotes ASK-1-Dependent Activation-Induced Apoptosis of Human Dendritic Cells

    Science.gov (United States)

    Chan, Vera S. F.; Chung, Nancy P. Y.; Wang, Shu-Rong; Li, Zhongye; Ma, Jing; Lin, Chia-Wei; Hsieh, Ya-Ju; Chang, Kao-Ping; Kung, Sui-Sum; Wu, Yi-Chia; Chu, Cheng-Wei; Tai, Hsiao-Ting; Gao, George F.; Zheng, Bojian; Yokoyama, Kazunari K.; Austyn, Jonathan M.; Lin, Chen-Lung S.

    2013-01-01

    During disease progression to AIDS, HIV-1 infected individuals become increasingly immunosuppressed and susceptible to opportunistic infections. It has also been demonstrated that multiple subsets of dendritic cells (DC), including DC-SIGN(+) cells, become significantly depleted in the blood and lymphoid tissues of AIDS patients, which may contribute to the failure in initiating effective host immune responses. The mechanism for DC depletion, however, is unclear. It is also known that vast quantities of viral envelope protein gp120 are shed from maturing HIV-1 virions and form circulating immune complexes in the serum of HIV-1-infected individuals, but the pathological role of gp120 in HIV-1 pathogenesis remains elusive. Here we describe a previously unrecognized mechanism of DC death in chronic HIV-1 infection, in which ligation of DC-SIGN by gp120 sensitizes DC to undergo accelerated apoptosis in response to a variety of activation stimuli. The cultured monocyte-derived DC and also freshly-isolated DC-SIGN(+) blood DC that were exposed to either cross-linked recombinant gp120 or immune-complex gp120 in HIV(+) serum underwent considerable apoptosis after CD40 ligation or exposure to bacterial lipopolysaccharide (LPS) or pro-inflammatory cytokines such as TNFα and IL-1β. Furthermore, circulating DC-SIGN(+) DC that were isolated directly from HIV-1(+) individuals had actually been pre-sensitized by serum gp120 for activation-induced exorbitant apoptosis. In all cases the DC apoptosis was substantially inhibited by DC-SIGN blockade. Finally, we showed that accelerated DC apoptosis was a direct consequence of excessive activation of the pro-apoptotic molecule ASK-1 and transfection of siRNA against ASK-1 significantly prevented the activation-induced excessive DC death. Our study discloses a previously unknown mechanism of immune modulation by envelope protein gp120, provides new insights into HIV immunopathogenesis, and suggests potential therapeutic approaches to

  15. Effectiveness and complications of SIGN intramedullary interlocking ...

    African Journals Online (AJOL)

    Effectiveness and complications of SIGN intramedullary interlocking nailing in the management of femoral and tibial fractures at Moi Teaching and Referral Hospital, Eldoret- Kenya: A retrospective study.

  16. Signed directed social network analysis applied to group conflict

    DEFF Research Database (Denmark)

    Zheng, Quan; Skillicorn, David; Walther, Olivier

    2015-01-01

    Real-world social networks contain relationships of multiple different types, but this richness is often ignored in graph-theoretic modelling. We show how two recently developed spectral embedding techniques, for directed graphs (relationships are asymmetric) and for signed graphs (relationships...

  17. Resolving the sign ambiguity in the singular value decomposition.

    Energy Technology Data Exchange (ETDEWEB)

    Bro, Rasmus (University of Copenhagen, Frederiksberg C, Denmark); Acar, Evrim (Rensselaer Polytechnic Institute, Troy, NY); Kolda, Tamara Gibson

    2007-10-01

    Many modern data analysis methods involve computing a matrix singular value decomposition (SVD) or eigenvalue decomposition (EVD). Principal components analysis is the time-honored example, but more recent applications include latent semantic indexing, hypertext induced topic selection (HITS), clustering, classification, etc. Though the SVD and EVD are well-established and can be computed via state-of-the-art algorithms, it is not commonly mentioned that there is an intrinsic sign indeterminacy that can significantly impact the conclusions and interpretations drawn from their results. Here we provide a solution to the sign ambiguity problem and show how it leads to more sensible solutions.

  18. Skin fibroblasts from individuals hemizygous for the familial adenopolyposis susceptibility gene show delayed crisis in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Chen, S.; Kazim, D.; Kraveka, J.; Pollack, R.E. (Columbia Univ., New York, NY (USA))

    1989-03-01

    Normal human fibroblast cells have not been reported to escape crisis--that is they die after about 24 doublings in culture. The authors have been studying the growth properties of skin fibroblast cells from persons in families with familial adenopolyposis of the colon (FAP). An individual hemizygous at the FAP locus will develop hyperplasia of the colonic epithelium followed by colonic polyps, both at an early age. Polyps themselves still retain a single functional FAP allele. A mutation or deletion in this allele in a polyp is hypothesized to lead to further loss of growth control; thus, a tumor is formed. They found that the in vitro life-span of skin fibroblast cells from FAP individuals and from some asymptomatic children were markedly extended when compared with normal individuals.

  19. Generalization of Clustering Coefficients to Signed Correlation Networks

    Science.gov (United States)

    Costantini, Giulio; Perugini, Marco

    2014-01-01

    The recent interest in network analysis applications in personality psychology and psychopathology has put forward new methodological challenges. Personality and psychopathology networks are typically based on correlation matrices and therefore include both positive and negative edge signs. However, some applications of network analysis disregard negative edges, such as computing clustering coefficients. In this contribution, we illustrate the importance of the distinction between positive and negative edges in networks based on correlation matrices. The clustering coefficient is generalized to signed correlation networks: three new indices are introduced that take edge signs into account, each derived from an existing and widely used formula. The performances of the new indices are illustrated and compared with the performances of the unsigned indices, both on a signed simulated network and on a signed network based on actual personality psychology data. The results show that the new indices are more resistant to sample variations in correlation networks and therefore have higher convergence compared with the unsigned indices both in simulated networks and with real data. PMID:24586367

  20. Prevalence of temporomandibular disorder signs in patients with schizophrenia.

    Science.gov (United States)

    Gurbuz, O; Alatas, G; Kurt, E

    2009-12-01

    The aim of this study was to determine the prevalence of temporomandibular disorder (TMD) signs in a group of institutionalized patients with schizophrenia. Three hundred thirty-nine patients with schizophrenia were examined and compared with 107 age-matched and gender-matched control subjects. TMD signs were evaluated according to the Research Diagnostic Criteria to assess temporomandibular joint pain to palpation, limitation of maximum mouth opening, alteration of mouth opening pathway (deviation/deflection) and temporomandibular joint noises. In addition, tooth wear was recorded for the assessment of bruxism. The prevalence of any TMD signs was observed higher (P = 0.001) in the patients with schizophrenia (284/339, 83.7%) than in the controls (72/107, 67.3%). The prevalence of more than one TMD sign was also significantly higher (P = 0.03) in the patients with schizophrenia (131/339, 38.6%) than in the controls (29/107, 27.1%). Significant differences between the two groups were apparent for joint pain on palpation (P = 0.006), deflection (P = 0.006) and joint sounds (P = 0.002). Severe tooth wear was evident in 39.2% of the patients with schizophrenia compared with 21.2% in the control group (P = 0.001). The finding of the present study showed that, compared to control population, chronically hospitalized patients with schizophrenia seem to be more prone to the development of TMD signs and severe tooth wear and bruxism.

  1. Nutrition affects insect susceptibility to Bt toxins

    Science.gov (United States)

    Deans, Carrie A.; Behmer, Spencer T.; Tessnow, Ashley E.; Tamez-Guerra, Patricia; Pusztai-Carey, Marianne; Sword, Gregory A.

    2017-01-01

    Pesticide resistance represents a major challenge to global food production. The spread of resistance alleles is the primary explanation for observations of reduced pesticide efficacy over time, but the potential for gene-by-environment interactions (plasticity) to mediate susceptibility has largely been overlooked. Here we show that nutrition is an environmental factor that affects susceptibility to Bt toxins. Protein and carbohydrates are two key macronutrients for insect herbivores, and the polyphagous pest Helicoverpa zea self-selects and performs best on diets that are protein-biased relative to carbohydrates. Despite this, most Bt bioassays employ carbohydrate-biased rearing diets. This study explored the effect of diet protein-carbohydrate content on H. zea susceptibility to Cry1Ac, a common Bt endotoxin. We detected a 100-fold increase in LC50 for larvae on optimal versus carbohydrate-biased diets, and significant diet-mediated variation in survival and performance when challenged with Cry1Ac. Our results suggest that Bt resistance bioassays that use ecologically- and physiologically-mismatched diets over-estimate susceptibility and under-estimate resistance.

  2. Real-Time Optical Antimicrobial Susceptibility Testing

    Science.gov (United States)

    Andersen, Klaus R.; Jørgensen, Erik; Droce, Aida; Olesen, Tom; Jensen, Bent B.; Rosenvinge, Flemming S.; Sondergaard, Teis E.

    2013-01-01

    Rapid antibiotic susceptibility testing is in high demand in health care fields as antimicrobial-resistant bacterial strains emerge and spread. Here, we describe an optical screening system (oCelloScope) which, based on time-lapse imaging of 96 bacteria-antibiotic combinations at a time, introduces real-time detection of bacterial growth and antimicrobial susceptibility with imaging material to support the automatically generated graphs. Automated antibiotic susceptibility tests of a monoculture showed statistically significant antibiotic effects within 6 min and within 30 min in complex samples from pigs suffering from catheter-associated urinary tract infections. The oCelloScope system provides a fast high-throughput screening method for detecting bacterial susceptibility that might entail an earlier diagnosis and introduction of appropriate targeted therapy and thus combat the threat from multidrug-resistant pathogenic bacteria. The oCelloScope system can be employed for a broad range of applications within bacteriology and might present new vistas as a point-of-care instrument in clinical and veterinary settings. PMID:23596243

  3. Abductor sign: a reliable new sign to detect unilateral non-organic paresis of the lower limb.

    Science.gov (United States)

    Sonoo, M

    2004-01-01

    To test a new neurological sign, the "abductor sign," which can distinguish between organic and non-organic leg paresis using synergic movements of the bilateral hip abductors. The subjects were 33 patients presenting with paresis of one leg, 17 of organic origin and 16 of non-organic origin (hysteria). To test the abductor sign, the examiner told the patient to abduct each leg, and opposed this movement with his hands placed on the lateral surfaces of the patient's legs. The leg contralateral to the abducted one showed opposite actions for organic paresis and non-organic paresis: for example, when the paretic leg was abducted, the sound leg stayed fixed in organic paresis, but moved in the hyperadducting direction in non-organic paresis. Hoover's sign was used for comparison in the same patients. The abductor sign gave the correct classification for all 33 cases. Hoover's sign was reliable if the results were carefully interpreted, but it was non-diagnostic for 16 patients because of strong hip extensors and in two because of strong hip flexors. Two patients with non-organic paresis succeeded in tricking the examiner by pretending full effort to lift the paretic leg. The abductor sign is a useful test to detect non-organic paresis, because (1) it is difficult for a hysterical patient to deceive the examiner, (2) the hip abductor is one of the most commonly involved muscles in pyramidal weakness, and (3) the results are easily visible as movement or non-movement of the unabducted leg.

  4. Significance of satellite sign and spot sign in predicting hematoma expansion in spontaneous intracerebral hemorrhage.

    Science.gov (United States)

    Yu, Zhiyuan; Zheng, Jun; Ali, Hasan; Guo, Rui; Li, Mou; Wang, Xiaoze; Ma, Lu; Li, Hao; You, Chao

    2017-11-01

    Hematoma expansion is related to poor outcome in spontaneous intracerebral hemorrhage (ICH). Recently, a non-enhanced computed tomography (CT) based finding, termed the 'satellite sign', was reported to be a novel predictor for poor outcome in spontaneous ICH. However, it is still unclear whether the presence of the satellite sign is related to hematoma expansion. Initial computed tomography angiography (CTA) was conducted within 6h after ictus. Satellite sign on non-enhanced CT and spot sign on CTA were detected by two independent reviewers. The sensitivity and specificity of both satellite sign and spot sign were calculated. Receiver-operator analysis was conducted to evaluate their predictive accuracy for hematoma expansion. This study included 153 patients. Satellite sign was detected in 58 (37.91%) patients and spot sign was detected in 38 (24.84%) patients. Among 37 patients with hematoma expansion, 22 (59.46%) had satellite sign and 23 (62.16%) had spot sign. The sensitivity and specificity of satellite sign for prediction of hematoma expansion were 59.46% and 68.97%, respectively. The sensitivity and specificity of spot sign were 62.16% and 87.07%, respectively. The area under the curve (AUC) of satellite sign was 0.642 and the AUC of spot sign was 0.746. (P=0.157) CONCLUSION: Our results suggest that the satellite sign is an independent predictor for hematoma expansion in spontaneous ICH. Although spot sign has the higher predictive accuracy, satellite sign is still an acceptable predictor for hematoma expansion when CTA is unavailable. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Neurological soft signs as an endophenotype in an African ...

    African Journals Online (AJOL)

    Introduction. Schizophrenia is a severe chronic psychiatric disorder that shows considerable clinical heterogeneity which arguably reflects the heterogeneous nature of susceptibility factors for the illness.1 Currently there is uncertainty as to whether this is a single disorder with different clinical manifestations or in.

  6. Gesture, sign, and language: The coming of age of sign language and gesture studies.

    Science.gov (United States)

    Goldin-Meadow, Susan; Brentari, Diane

    2017-01-01

    How does sign language compare with gesture, on the one hand, and spoken language on the other? Sign was once viewed as nothing more than a system of pictorial gestures without linguistic structure. More recently, researchers have argued that sign is no different from spoken language, with all of the same linguistic structures. The pendulum is currently swinging back toward the view that sign is gestural, or at least has gestural components. The goal of this review is to elucidate the relationships among sign language, gesture, and spoken language. We do so by taking a close look not only at how sign has been studied over the past 50 years, but also at how the spontaneous gestures that accompany speech have been studied. We conclude that signers gesture just as speakers do. Both produce imagistic gestures along with more categorical signs or words. Because at present it is difficult to tell where sign stops and gesture begins, we suggest that sign should not be compared with speech alone but should be compared with speech-plus-gesture. Although it might be easier (and, in some cases, preferable) to blur the distinction between sign and gesture, we argue that distinguishing between sign (or speech) and gesture is essential to predict certain types of learning and allows us to understand the conditions under which gesture takes on properties of sign, and speech takes on properties of gesture. We end by calling for new technology that may help us better calibrate the borders between sign and gesture.

  7. Tritium in Exit Signs | RadTown USA | US EPA

    Science.gov (United States)

    2017-08-07

    Many exit signs contain tritium to light the sign without batteries or electricity. Using tritium in exit signs allows the sign to remain lit if the power goes out. Tritium is most dangerous when it is inhaled or swallowed. Never tamper with a tritium exit sign. If a tritium exit sign is broken, leave the area immediately and notify the building maintenance staff.

  8. Assessment of relatedness between neurocan gene as bipolar disorder susceptibility locus and schizophrenia

    Directory of Open Access Journals (Sweden)

    Lilijana Oruč

    2012-11-01

    Full Text Available Large scale genetic association meta-analyses showed that neurocan (NCAN gene polymorphism rs1064395 is susceptibility locus for bipolar disorder. These studies also included patients with bipolar disorder originated from Bosnia and Herzegovina. Followed by theory of shared genetic elements between bipolar disorder and schizophrenia susceptibility, other studies explored several genetic factors with schizophrenia vulnerability as well. In this work, authors investigated the association between previously confirmed bipolar disorder genetic risk factor-neurocan with schizophrenia in a population sample of Bosnia and Herzegovina.Ethical aspects of this research were assessed by Ethics Committee of Clinical Center University of Sarajevo. Blood samples for DNA extraction were taken from the total of 86 patients and healthy individuals who previously signed informed consent. Genotyping for rs 1064395 was done using direct sequencing method. A case-control analysis of common genetic polymorphism within neurocan gene and schizophrenia status in a consecutively sampled patient cohort have been done using Fisher-exact test with odds-ratio calculation. No statistically significant allele and genotype association with disease status was found (p>0.05.Our finding supports the fact that large-scale genetic association studies approach need to be employed when detecting the variants with small additive effect in phenotypes with complex ethiology.

  9. The aurora sign in a patient with type B Niemann-Pick disease

    Energy Technology Data Exchange (ETDEWEB)

    Costa e. Silva, Eduardo J. da [Instituto Materno Infantil Professor Fernando Figueira, Departamento de Radiologia, Recife, Pernambuco (Brazil); IMIP, Departamento de Radiologia-Rua dos Coelhos, Recife, PE (Brazil); Cavalcanti de Albuquerque, Silvio; Queiroz Praxedes, Eduardo L. de; Amaral, Fernando J. do [Instituto Materno Infantil Professor Fernando Figueira, Departamento de Radiologia, Recife, Pernambuco (Brazil)

    2007-01-15

    The aurora sign, a sonographic sign found on the sagittal and transverse view, refers to multiple bands of ring-down artifacts posterior to the right hemidiaphragm. Parenchymal lung disease should be suspected when this is present. We report a case of type B Niemann-Pick disease with pulmonary involvement and the aurora sign on abdominal sonography. High-resolution CT of the chest showed corresponding thickened interlobular septa. (orig.)

  10. Identification and characterization of DC-SIGN-binding glycoproteins in allergenic foods.

    Science.gov (United States)

    Kamalakannan, M; Chang, L M; Grishina, G; Sampson, H A; Masilamani, M

    2016-08-01

    DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin) is a C-type lectin receptor expressed on macrophages and dendritic cells. DC-SIGN has high affinity for fucosylated glycans in several plant glycoproteins and pathogens. DC-SIGN is thought to be crucial for the development of allergic sensitization. However, the precise role of DC-SIGN in food allergy pathogenesis is not yet understood. We sought to characterize DC-SIGN-binding glycoproteins in a panel of allergenic and non-allergenic foods. Fluorescent-labeled peanut and soy extracts were used to test protein binding to human monocyte-derived dendritic cells (DCs) by flow cytometry. DC-SIGN-blocking assays were performed by incubating DCs with food extracts followed by staining with anti-DC-SIGN antibody. Using a DC-SIGN-Fc chimera, food extracts were tested for binding by ELISA and autoradiography. IgE immunoblotting was performed with pooled sera from food-allergic subjects. DC activation and maturation were assessed by flow cytometry. We demonstrate that peanut agglutinin, a minor peanut allergen, is a novel ligand for DC-SIGN. Peanut agglutinin activates DCs to induce the expression of costimulatory molecules in vitro. We present a comprehensive report on the characterization of DC-SIGN-binding proteins in common allergenic foods such as peanut, soy, tree nuts, egg, and milk. Foods that rarely induce allergy, such as pine nuts, chickpea, and corn, showed no binding to DC-SIGN. Several DC-SIGN-binding proteins show reactivity in serum IgE immunoblots. We have also identified novel non-IgE-binding proteins that interact with DC-SIGN; these proteins may be important for regulating immune responses to these foods. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Sign language in dental education-A new nexus.

    Science.gov (United States)

    Jones, T; Cumberbatch, K

    2017-08-14

    The introduction of the landmark mandatory teaching of sign language to undergraduate dental students at the University of the West Indies (UWI), Mona Campus in Kingston, Jamaica, to bridge the communication gap between dentists and their patients is reviewed. A review of over 90 Doctor of Dental Surgery and Doctor of Dental Medicine curricula in North America, the United Kingdom, parts of Europe and Australia showed no inclusion of sign language in those curricula as a mandatory component. In Jamaica, the government's training school for dental auxiliaries served as the forerunner to the UWI's introduction of formal training of sign language in 2012. Outside of the UWI, a couple of dental schools have sign language courses, but none have a mandatory programme as the one at the UWI. Dentists the world over have had to rely on interpreters to sign with their deaf patients. The deaf in Jamaica have not appreciated the fact that dentists cannot sign and they have felt insulted and only go to the dentist in emergency situations. The mandatory inclusion of sign language in the Undergraduate Dental Programme curriculum at The University of the West Indies, Mona Campus, sought to establish a direct communication channel to formally bridge this gap. The programme of two sign language courses and a direct clinical competency requirement was developed during the second year of the first cohort of the newly introduced undergraduate dental programme through a collaborating partnership between two faculties on the Mona Campus. The programme was introduced in 2012 in the third year of the 5-year undergraduate dental programme. To date, two cohorts have completed the programme, and the preliminary findings from an ongoing clinical study have shown a positive impact on dental care access and dental treatment for deaf patients at the UWI Mona Dental Polyclinic. The development of a direct communication channel between dental students and the deaf that has led to increased dental

  12. God and the World of Signs

    DEFF Research Database (Denmark)

    Kristensen, Johanne Stubbe T

    2016-01-01

    Review of Robinson, Andrew (Andrew John Nottage). God and the world of signs: Trinity, evolution, and the metaphysical semiotics of C. S. Peirce. Publisher: Leiden: Brill, 2010. ISBN: 9789004187993......Review of Robinson, Andrew (Andrew John Nottage). God and the world of signs: Trinity, evolution, and the metaphysical semiotics of C. S. Peirce. Publisher: Leiden: Brill, 2010. ISBN: 9789004187993...

  13. A short note on sign changes

    Indian Academy of Sciences (India)

    In this paper, we present a quantitative result for the number of sign changes for the sequences { a ( n j ) } n ≥ 1 , j = 2 , 3 , 4 of the Fourier coefficients of normalized Hecke eigencusp forms for the full modular group S L 2 ( Z ) . We also prove a similar kind of quantitative result for the number of sign changes of the ...

  14. Sign and Word Recognition: A First Comparison.

    Science.gov (United States)

    Grosjean, Francois

    1981-01-01

    The results of a word recognition study are compared to those of a sign recognition study in order to determine which aspects of lexical access are comparable in speech and sign, and which are specific to each of the two language modalities. The "gating paradigm" was used in both studies. (Author/AMH)

  15. A new radiologic sign of subpulmonic effusion.

    Science.gov (United States)

    Schwarz, M I; Marmorstein, B L

    1975-02-01

    A new radiologic sign of subpulmonic effusion is described. That is obliteration of the intrapulmonary blood vessels which are seen below the level of the diaphragmatic dome. One hundred normal chest films are reviewed as well as nine patients with subpulmonic effusions. In three of the patients with subpulmonic effusions, this sign was the first evidence of pleural effusion.

  16. Have Any Effect on Moriarty Sign?

    African Journals Online (AJOL)

    ABSTRACT. Moriarty sign designates that when split skin donor site is more painful than recipient site, good graft take is likely. This prospective study was designed for the dual purpose of confirming the validity of Moriarty sign and to determine if bupivacaine topical anaesthetic application to split skin donor site will ...

  17. Warning signs and symptoms of heart disease

    Science.gov (United States)

    ... breath may be signals that something is wrong. Learning the warning signs can help you get treatment and help prevent ... the face drooping, difficulty with speaking or understanding language. ... means that you need more rest. But feeling run down can be a sign of a more serious problem. Fatigue may be ...

  18. 46 CFR 154.1830 - Warning sign.

    Science.gov (United States)

    2010-10-01

    ... (2) Facing outboard towards the water so that the sign may be seen from the water. (b) Except as provided in paragraph (e) of this section, each warning sign must have the following words: (1) Warning. (2) Dangerous Cargo. (3) No Visitors. (4) No Smoking. (5) No Open Lights. (c) Each letter in the words on the...

  19. Generating Signed Distance Fields From Triangle Meshes

    DEFF Research Database (Denmark)

    Bærentzen, Jakob Andreas; Aanæs, Henrik

    A method for generating a discrete, signed 3D distance field is proposed. Distance fields are used in a number of contexts. In particular the popular level set method is usually initialized by a distance field. The main focus of our work is on simplifying the computation of the sign when generati...

  20. Infant Sign Training and Functional Analysis

    Science.gov (United States)

    Normand, Matthew P.; Machado, Mychal A.; Hustyi, Kristin M.; Morley, Allison J.

    2011-01-01

    We taught manual signs to typically developing infants using a reversal design and caregiver-nominated stimuli. We delivered the stimuli on a time-based schedule during baseline. During the intervention, we used progressive prompting and reinforcement, described by Thompson et al. (2004, 2007), to establish mands. Following sign training, we…

  1. Indoor sign recognition for the blind

    CSIR Research Space (South Africa)

    Kunene, D

    2016-09-01

    Full Text Available (SURF). Once a sign has been detected, this information is communicated to the user via stereo headsets. To evaluate the system's performance, several random pictures with and without signs were used to determine the system's detection rate. The user...

  2. Sign (di) lemma for dimension shifting

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 119; Issue 2. Sign (di)Lemma for ... Getting these signs right is important in order to avoid basic contradictions. We illustrate the ... Nitin Nitsure1. School of Mathematics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, India ...

  3. The grammaticalization of gestures in sign languages

    NARCIS (Netherlands)

    van Loon, E.; Pfau, R.; Steinbach, M.; Müller, C.; Cienki, A.; Fricke, E.; Ladewig, S.H.; McNeill, D.; Bressem, J.

    2014-01-01

    Recent studies on grammaticalization in sign languages have shown that, for the most part, the grammaticalization paths identified in sign languages parallel those previously described for spoken languages. Hence, the general principles of grammaticalization do not depend on the modality of language

  4. Life-sign detection with FMCW radar

    NARCIS (Netherlands)

    Jong, A.J. de; Anitori, L.

    2008-01-01

    In this paper we present some preliminary results on life-sign detection using FMCW radars. Several persons were observed from different aspects with carrier frequencies between 2.4 GHz and 24 GHz. In most cases, reliable life-sign measurements could be done, although we found a considerable

  5. Smartphone Based Traffic Sign Inventory and Assessment.

    Science.gov (United States)

    2016-01-01

    Road signs are an important part of the infrastructure and are needed to ensure smooth and : safe traffic flow. Faded, occluded, damaged or vandalized signs can confuse or misinform : drivers and lead to unsafe driving behavior. E.g. if a driver is n...

  6. Historical Development of Hong Kong Sign Language

    Science.gov (United States)

    Sze, Felix; Lo, Connie; Lo, Lisa; Chu, Kenny

    2013-01-01

    This article traces the origins of Hong Kong Sign Language (hereafter HKSL) and its subsequent development in relation to the establishment of Deaf education in Hong Kong after World War II. We begin with a detailed description of the history of Deaf education with a particular focus on the role of sign language in such development. We then…

  7. Research Ethics in Sign Language Communities

    Science.gov (United States)

    Harris, Raychelle; Holmes, Heidi M.; Mertens, Donna M.

    2009-01-01

    Codes of ethics exist for most professional associations whose members do research on, for, or with sign language communities. However, these ethical codes are silent regarding the need to frame research ethics from a cultural standpoint, an issue of particular salience for sign language communities. Scholars who write from the perspective of…

  8. Numeral Variation in New Zealand Sign Language

    Science.gov (United States)

    McKee, David; McKee, Rachel; Major, George

    2011-01-01

    Lexical variation abounds in New Zealand Sign Language (NZSL) and is commonly associated with the introduction of the Australasian Signed English lexicon into Deaf education in 1979, before NZSL was acknowledged as a language. Evidence from dictionaries of NZSL collated between 1986 and 1997 reveal many coexisting variants for the numbers from one…

  9. Fluorescent retroreflective signing of work zones : abstract

    NARCIS (Netherlands)

    Vos, A.P. de; Horst, A.R.A. van der; Alferdinck, J.W.A.M.; Kooi, F.L.

    1999-01-01

    Fluorescent retroreflective materials increase the brightness of traffic signs. In construction work zones a benefit is expected from the increased conspicuity of fluorescent retroreflective signs. Fluorescent material can be used instead of non-fluorescent materials both for the advance warning

  10. Visual sonority in Brazilian Sign Language literature

    Directory of Open Access Journals (Sweden)

    Marilyn Mafra Klamt

    2017-03-01

    Full Text Available ABSTRACT The idea of sonority in sign languages was treated by Perlmutter (1992 as perceptibility, a property of a segment that uses movement rather than one in which the hands stay in the same position. Sandler (1993 states that the visual salience of movement in sign languages plays a role similar to sonority in spoken languages. For Brentari (1998, perceptually, a sign is visible from considerable distances, and measurement of its visual sonority is based on the joints involved in its production. This work focuses on visual sonority in literature in Brazilian Sign Language and considers the relevance of manual and non-manual elements, rhythm, symmetry, the scale of signs, and the effect of video on this concept. Two signed stories “The King’s Parrot” and “Little Ping Pong Ball” were analysed, highlighting specific signs in which the use of joints, non-manual features, and other resources are influenced by the size of the performance space and the distance of the audience from the signing. Three types of ‘sonority’ were observed: in the movement of the whole body on the stage, in the size of arms and trunk movement, and in the hands. In addition to the joints, non-manual features, rhythm and symmetry play an important role in visual sonority and influence the viewer’s experience.

  11. Audience Effects in American Sign Language Interpretation

    Science.gov (United States)

    Weisenberg, Julia

    2009-01-01

    There is a system of English mouthing during interpretation that appears to be the result of language contact between spoken language and signed language. English mouthing is a voiceless visual representation of words on a signer's lips produced concurrently with manual signs. It is a type of borrowing prevalent among English-dominant…

  12. Categorical Perception in American Sign Language.

    Science.gov (United States)

    Emmorey, Karen; McCullough, Stephen; Brentari, Diane

    2003-01-01

    Two experiments examined whether Deaf signers or hearing nonsigners exhibit categorical perception (CP) for hand configuration or for place of articulation in American Sign Language. Findings that signers and nonsigners performed similarly suggests that these categories in American Sign Language have a perceptual as well as a linguistic basis.…

  13. A Field Guide for Sign Language Research.

    Science.gov (United States)

    Stokoe, William; Kuschel, Rolf

    Field researchers of sign language are the target of this methodological guide. The prospective researcher is briefed on the rationale of sign language study as language study and as distinct from the study of kinesics. Subjects covered include problems of translating, use of interpreters, and ethics. Instruments for obtaining social and language…

  14. When does Iconicity in Sign Language Matter?

    Science.gov (United States)

    Baus, Cristina; Carreiras, Manuel; Emmorey, Karen

    2013-03-01

    We examined whether iconicity in American Sign Language (ASL) enhances translation performance for new learners and proficient signers. Fifteen hearing nonsigners and 15 proficient ASL-English bilinguals performed a translation recognition task and a production translation task. Nonsigners were taught 28 ASL verbs (14 iconic; 14 non-iconic) prior to performing these tasks. Only new learners benefited from sign iconicity, recognizing iconic translations faster and more accurately and exhibiting faster forward (English-ASL) and backward (ASL-English) translation times for iconic signs. In contrast, proficient ASL-English bilinguals exhibited slower recognition and translation times for iconic signs. We suggest iconicity aids memorization in the early stages of adult sign language learning, but for fluent L2 signers, iconicity interacts with other variables that slow translation (specifically, the iconic signs had more translation equivalents than the non-iconic signs). Iconicity may also have slowed translation performance by forcing conceptual mediation for iconic signs, which is slower than translating via direct lexical links.

  15. Signs: een wetenschappelijk tijdschrift in transatlantisch perspectief

    Directory of Open Access Journals (Sweden)

    Ieme van der Poel

    1997-06-01

    Full Text Available Het Amerikaanse feministische tijdschrift Signs is een belangrijke bron voor de receptie van het Franse feminisme in Amerika. Bovendien geeft het een indruk van het verschil tussen de academische, Amerikaanse vrouwenstudies enerzijds, en de literair en politiek getinte Franse vrouwenbeweging anderzijds. Ieme van der Poel analyseert de jaargangen van Signs tussen 1975 en 1981 vanuit deze gezichtspunten.

  16. Sign Language and the Brain: A Review

    Science.gov (United States)

    Campbell, Ruth; MacSweeney, Mairead; Waters, Dafydd

    2008-01-01

    How are signed languages processed by the brain? This review briefly outlines some basic principles of brain structure and function and the methodological principles and techniques that have been used to investigate this question. We then summarize a number of different studies exploring brain activity associated with sign language processing…

  17. [Antimicrobial susceptibility in Chile 2012].

    Science.gov (United States)

    Cifuentes-D, Marcela; Silva, Francisco; García, Patricia; Bello, Helia; Briceño, Isabel; Calvo-A, Mario; Labarca, Jaime

    2014-04-01

    Bacteria antimicrobial resistance is an uncontrolled public health problem that progressively increases its magnitude and complexity. The Grupo Colaborativo de Resistencia, formed by a join of experts that represent 39 Chilean health institutions has been concerned with bacteria antimicrobial susceptibility in our country since 2008. In this document we present in vitro bacterial susceptibility accumulated during year 2012 belonging to 28 national health institutions that represent about 36% of hospital discharges in Chile. We consider of major importance to report periodically bacteria susceptibility so to keep the medical community updated to achieve target the empirical antimicrobial therapies and the control measures and prevention of the dissemination of multiresistant strains.

  18. Pathogenesis of neurological signs associated with bovine enteric coccidiosis: a prospective study and review.

    Science.gov (United States)

    Isler, C M; Bellamy, J E; Wobeser, G A

    1987-01-01

    Various hypotheses have been proposed for the pathogenesis of the neurological signs associated with bovine enteric coccidiosis. We undertook a prospective study of cases of bovine enteric coccidiosis with and without nervous signs to test the validity of these hypotheses and explore other possible pathophysiological mechanisms. Clinical, pathological and toxicological data from 12 calves with, and 15 calves without, neurological signs were compared. Calves with neurological signs had a lower liver Cu concentration (p less than 0.01) and a higher plasma glucose concentration (p less than 0.05) than did calves without neurological signs. Hyperglycemia and Cu deficiency may increase the susceptibility to central nervous system damage, but are not likely to account for the onset of neurological signs in calves with enteric coccidiosis. The results of the study suggest that the following are not involved in the pathogenesis of "nervous coccidiosis": disturbance of serum Na, K, Ca, P, or Mg concentration, vitamin A deficiency, thiamine deficiency, anemia, lead intoxication, uremia, Haemophilus somnus meningoencephalitis, severity of coccidial infection, gross alterations in intestinal bacterial flora and hepatopathy. PMID:3607655

  19. Adapting the Assessing British Sign Language Development: Receptive Skills Test into American sign language

    OpenAIRE

    Enns, C. J.; Herman, R.

    2011-01-01

    Signed languages continue to be a key element of deaf education programs that incorporate a bilingual approach to teaching and learning. In order to monitor the success of bilingual deaf education programs, and in particular to monitor the progress of children acquiring signed language, it is essential to develop an assessment tool of signed language skills. Although researchers have developed some checklists and experimental tests related to American Sign Language (ASL) assessment, at this t...

  20. Eigen-Gradients for Traffic Sign Recognition

    Directory of Open Access Journals (Sweden)

    Sheila Esmeralda Gonzalez-Reyna

    2013-01-01

    Full Text Available Traffic sign detection and recognition systems include a variety of applications like autonomous driving, road sign inventory, and driver support systems. Machine learning algorithms provide useful tools for traffic sign identification tasks. However, classification algorithms depend on the preprocessing stage to obtain high accuracy rates. This paper proposes a road sign characterization method based on oriented gradient maps and the Karhunen-Loeve transform in order to improve classification performance. Dimensionality reduction may be important for portable applications on resource constrained devices like FPGAs; therefore, our approach focuses on achieving a good classification accuracy by using a reduced amount of attributes compared to some state-of-the-art methods. The proposed method was tested using German Traffic Sign Recognition Benchmark, reaching a dimensionality reduction of 99.3% and a classification accuracy of 95.9% with a Multi-Layer Perceptron.

  1. Road Signs for UV-Completion

    CERN Document Server

    Dvali, Gia; Gomez, Cesar

    2012-01-01

    We confront the concepts of Wilsonian UV-completion versus self-completion by Classicalization in theories with derivatively-coupled scalars. We observe that the information about the UV-completion road is encoded in the sign of the derivative terms. We note that the sign of the derivative couplings for which there is no consistent Wilsonian UV-completion is the one that allows for consistent classicalons. This is an indication that for such a sign the vertex must be treated as fundamental and the theory self-protects against potential inconsistencies, such as superluminality, via self-completion by classicalization. Applying this reasoning to the UV-completion of the Standard Model, we see that the information about the Higgs versus classicalization is encoded in the sign of the scattering amplitude of longitudinal W-bosons. Negative sign excludes Higgs or any other weakly-coupled Wilsonian physics.

  2. Sharing Vital Signs between mobile phone applications.

    Science.gov (United States)

    Karlen, Walter; Dumont, Guy A; Scheffer, Cornie

    2014-01-01

    We propose a communication library, ShareVitalSigns, for the standardized exchange of vital sign information between health applications running on mobile platforms. The library allows an application to request one or multiple vital signs from independent measurement applications on the Android OS. Compatible measurement applications are automatically detected and can be launched from within the requesting application, simplifying the work flow for the user and reducing typing errors. Data is shared between applications using intents, a passive data structure available on Android OS. The library is accompanied by a test application which serves as a demonstrator. The secure exchange of vital sign information using a standardized library like ShareVitalSigns will facilitate the integration of measurement applications into diagnostic and other high level health monitoring applications and reduce errors due to manual entry of information.

  3. The Babinski-2 sign in hemifacial spasm.

    Science.gov (United States)

    Pawlowski, Matthias; Gess, Burkhard; Evers, Stefan

    2013-08-01

    Hemifacial spasm is a common movement disorder. Differential diagnosis relies on clinical examination and is often difficult. The Babinski-2 sign is an underrecognized physical sign specifically found in patients with hemifacial spasm, although its prevalence and usefulness are a matter of debate. We examined 35 patients with hemifacial spasm prospectively for the presence of the Babinski-2 sign. We evaluated its correlation with severity of hemifacial spasm, concomitant facial nerve paralysis, and response to botulinum toxin. Twelve patients with blepharospasm served as the control population. The data for the Babinski-2 sign demonstrated high prevalence (86%), high specificity (100%), and high interrater reliability (92%). Increased awareness of the Babinski-2 sign may aid diagnosis and potentially prompt earlier initiation of appropriate treatment. © 2013 Movement Disorder Society. Copyright © 2013 Movement Disorder Society.

  4. Application of Changeable Message Signs in Traffic

    Directory of Open Access Journals (Sweden)

    Ivan Dadić

    2003-09-01

    Full Text Available In the Republic of Croatia, changeable message signs arebeing introduced on high-serviceability roads in order to improvethe flow management in the network and increase thetraffic safety leveL The equipment installed in the past was notset according to the unique criteria, thus resulting in the installationof relatively incompatible equipment set in a disorganisedmanner. The work presents the basic guidelines in applyingchangeable message signs, primarily on the Croatian motorways.The types and levels of influence on the traffic are described,and the traffic and weather criteria for the applicationof changeable message signs are defined. The paper also analysesthe principles of installing the changeable message signs onroads and road facilities, recommending priorities in presentingthe changeable signs.

  5. The Sign "Institute" and Its Derivatives: A Family of Culturally Important ASL Signs

    Science.gov (United States)

    Kowalsky, Jilly; Meier, Richard P.

    2013-01-01

    The sign "institute" is the source of a family of ASL signs that are used to refer to residential schools for deaf children and to other institutions. The members of the "institute" sign family--although initialized--are well-established within the Deaf community and, importantly, are used to refer to highly-valued aspects of Deaf culture. This is…

  6. Crash test and evaluation of temporary wood sign support system for large guide signs.

    Science.gov (United States)

    2016-07-01

    The objective of this research task was to evaluate the impact performance of a temporary wood sign support : system for large guide signs. It was desired to use existing TxDOT sign hardware in the design to the extent possible. : The full-scale cras...

  7. Development of Sign Language Communication Skill on Children through Augmented Reality and the MuCy Mode

    OpenAIRE

    Angélica GONZÁLEZ ARRIETA; Cadeñanes Garnica, Jorge J.

    2016-01-01

    This paper shows a Sign Language Teaching Model (SLTM) called: Multi-language Cycle for Sign Language Understanding (MuCy). It serves as complementary pedagogical resource for Sign Language (SL) teaching. A pilot lesson with the Rainbow Colors was conducted at the Association of Parents of Deaf Children of Salamanca in order to determine the Percentage of Development of the Sign Language Communication Skill (SLCS) and others within a Collaborative Learning Environment with Mixed-Reality (CLEMR).

  8. pso.ATION AND ANTIMICROBIAL SUSCEPTIBILITY

    African Journals Online (AJOL)

    isolates vere made using standard methods, Antibiotic susceptibility tests against commonly prescribed ... Acute otitis media is rapid with short .... sensitivity tests. Antimicrobial susceptibility tests: The antimicrobial susceptibility patterns of major Gram positive and negative bacterial isolates obtained from clinical specimens.

  9. Pope's hat sign: another valuable CT finding of early acute cholecystitis.

    Science.gov (United States)

    Choi, Seo-Youn; Lee, Hae Kyung; Yi, Boem Ha; Lee, Min Hee; Lee, Ji Eun; Min, Ji Hye; Moon, Ji Yoon; Kim, Jung Hoon

    2017-12-02

    To determine the diagnostic performance of minor computed tomography (CT) findings for acute cholecystitis and demonstrate the incremental benefit of pope's hat sign as an additional minor CT finding in patients suspected to have early acute cholecystitis. Two radiologists reviewed CT scans of 116 patients with early acute cholecystitis and 116 control patients. All cases in the patient group were surgically proven to have acute cholecystitis and preoperative dynamic CT scans. Evaluated CT parameters included major criteria (gallstone, distension of gallbladder (GB) lumen, GB wall edema, pericholecystic fat infiltration, and pericholecystic fluid collection) and minor criteria (GB bed hyperemia, tensile GB fundus sign, hyperdense GB wall sign, increased bile attenuation within GB, and pope's hat sign). In a univariate analysis, among the minor criteria, GB bed hyperemia, tensile GB fundus sign, increased bile attenuation within GB, and pope's hat sign were more frequently observed (P sign, and GB lumen > 3.05 cm were significant findings for differentiating the two groups (P sign exhibited the highest specificity (96.5%) and the combination of all three findings showed the highest sensitivity (94.0%). Pope's hat sign is a new finding that could improve CT diagnostic performance for early acute cholecystitis in patients with RUQ pain in the emergency department. The combination of pope's hat sign with GB bed hyperemia or GB lumen distension > 3.05 cm may be even more helpful in the early stage or in mild forms of acute cholecystitis.

  10. Hypnotic susceptibility and dream characteristics.

    Science.gov (United States)

    Zamore, N; Barrett, D

    1989-11-01

    This study examined the relationship of hypnotic susceptibility to a variety of dream characteristics and types of dream content. A Dream Questionnaire was constructed synthesizing Gibson's dream inventory and Hilgard's theoretical conceptions of hypnosis. Employing the Harvard Group Scale of Hypnotic Susceptibility and the Field Inventory for evaluating hypnotic response, several dream dimensions correlated significantly with hypnotizability. For subjects as a whole, the strongest correlates were the frequency of dreams which they believed to be precognitive and out-of-body dreams. Ability to dream on a chosen topic also correlated significantly with hypnotic susceptibility for both genders. For females only, there was a negative correlation of hypnotic susceptibility to flying dreams. Absorption correlated positively with dream recall, ability to dream on a chosen topic, reports of conflict resolution in dreams, creative ideas occurring in dreams, amount of color in dreams, pleasantness of dreams, bizarreness of dreams, flying dreams and precognitive dreams.

  11. Ancestral susceptibility to colorectal cancer

    Czech Academy of Sciences Publication Activity Database

    Huhn, S.; Pardini, Barbara; Naccarati, Alessio; Vodička, Pavel (ed.); Hemminki, K.; Försti, A.

    2012-01-01

    Roč. 27, č. 2 (2012), s. 197-204 ISSN 0267-8357 R&D Projects: GA ČR GA310/07/1430; GA ČR GAP304/10/1286 Grant - others:EU FP7(XE) HEALTH-F4-2007-200767 Institutional research plan: CEZ:AV0Z50390512 Keywords : cancer susceptibility * molecular epidemiology * genetic susceptibility Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.500, year: 2012

  12. The history of sign language and deaf education in Turkey.

    Science.gov (United States)

    Kemaloğlu, Yusuf Kemal; Kemaloğlu, Pınar Yaprak

    2012-01-01

    Sign language is the natural language of the prelingually deaf people particularly without hearing-speech rehabilitation. Otorhinolaryngologists, regarding health as complete physical, mental and psychosocial well-being, aim hearing by diagnosing deafness as deviance from normality. However, it's obvious that the perception conflicted with the behavior which does not meet the mental and social well-being of the individual also contradicts with the definition mentioned above. This article aims to investigate the effects of hearing-speech target ignoring the sign language in Turkish population and its consistency with the history through statistical data, scientific publications and historical documents and to support critical perspective on this issue. The study results showed that maximum 50% of the deaf benefited from hearing-speech program for last 60 years before hearing screening programs; however, systems including sign language in education were not generated. In the light of these data, it is clear that the approach ignoring sign language particularly before the development of screening programs is not reasonable. In addition, considering sign language being part of the Anatolian history from Hittites to Ottomans, it is a question to be answered that why evaluation, habilitation and education systems excluding sign language are still the only choice for deaf individuals in Turkey. Despite legislative amendments in the last 6-7 years, the primary cause of failure to come into force is probably because of inadequate conception of the issue content and importance, as well as limited effort to offer solutions by academicians and authorized politicians. Within this context, this paper aims to make a positive effect on this issue offering a review for the medical staff, particularly otorhinolaryngologists and audiologists.

  13. A Comparison of Comprehension Processes in Sign Language Interpreter Videos with or without Captions.

    Science.gov (United States)

    Debevc, Matjaž; Milošević, Danijela; Kožuh, Ines

    2015-01-01

    One important theme in captioning is whether the implementation of captions in individual sign language interpreter videos can positively affect viewers' comprehension when compared with sign language interpreter videos without captions. In our study, an experiment was conducted using four video clips with information about everyday events. Fifty-one deaf and hard of hearing sign language users alternately watched the sign language interpreter videos with, and without, captions. Afterwards, they answered ten questions. The results showed that the presence of captions positively affected their rates of comprehension, which increased by 24% among deaf viewers and 42% among hard of hearing viewers. The most obvious differences in comprehension between watching sign language interpreter videos with and without captions were found for the subjects of hiking and culture, where comprehension was higher when captions were used. The results led to suggestions for the consistent use of captions in sign language interpreter videos in various media.

  14. The "SignOn"-Model for Teaching Written Language to Deaf People

    Directory of Open Access Journals (Sweden)

    Marlene Hilzensauer

    2012-08-01

    Full Text Available This paper shows a method of teaching written language to deaf people using sign language as the language of instruction. Written texts in the target language are combined with sign language videos which provide the users with various modes of translation (words/phrases/sentences. As examples, two EU projects for English for the Deaf are presented which feature English texts and translations into the national sign languages of all the partner countries plus signed grammar explanations and interactive exercises. Both courses are web-based; the programs may be accessed free of charge via the respective homepages (without any download or log-in.

  15. Ergonomic analysis of safety signs: a focus of informational and cultural ergonomics.

    Science.gov (United States)

    Cavalcanti, Janaina; Soares, Marcelo

    2012-01-01

    This paper presents the results of a research carried out in the states of Pernambuco and Rio Grande do Sul, Brazil about differences and similarities in the graphic representation of safety signs at factories of food, steel, shoes and construction/ building industries, together with their workers' opinions on the security signs. The overall results show differences in the sign structure across the states, confirming the influence of cultural differences on the design of safety signs, which must be taken into account during the design process.

  16. Security Analysis of Randomize-Hash-then-Sign Digital Signatures

    DEFF Research Database (Denmark)

    Gauravaram, Praveen; Knudsen, Lars Ramkilde

    2012-01-01

    a variant of the RMX hash function mode and published this standard in the Special Publication (SP) 800-106.In this article, we first discuss a generic online birthday existential forgery attack of Dang and Perlner on the RMX-hash-then-sign schemes. We show that a variant of this attack can be applied...... to forge the other randomize-hash-then-sign schemes. We point out practical limitations of the generic forgery attack on the RMX-hash-then-sign schemes. We then show that these limitations can be overcome for the RMX-hash-then-sign schemes if it is easy to find fixed points for the underlying compression...... birthday forgery attack on this class of signatures by using a variant of Dean’s method of finding fixed point expandable messages for hash functions based on the Davies-Meyer construction. This forgery attack is also applicable to signature schemes based on the variant of RMX standardized by NIST in SP...

  17. Behaviorally Assessed Sleep and Susceptibility to the Common Cold.

    Science.gov (United States)

    Prather, Aric A; Janicki-Deverts, Denise; Hall, Martica H; Cohen, Sheldon

    2015-09-01

    Short sleep duration and poor sleep continuity have been implicated in the susceptibility to infectious illness. However, prior research has relied on subjective measures of sleep, which are subject to recall bias. The aim of this study was to determine whether sleep, measured behaviorally using wrist actigraphy, predicted cold incidence following experimental viral exposure. A total of 164 healthy men and women (age range, 18 to 55 y) volunteered for this study. Wrist actigraphy and sleep diaries assessed sleep duration and sleep continuity over 7 consecutive days. Participants were then quarantined and administered nasal drops containing the rhinovirus, and monitored over 5 days for the development of a clinical cold (defined by infection in the presence of objective signs of illness). Logistic regression analysis revealed that actigraphy- assessed shorter sleep duration was associated with an increased likelihood of development of a clinical cold. Specifically, those sleeping cold compared to those sleeping > 7 h per night; those sleeping 6.01 to 7 h were at no greater risk (OR = 1.66; 95% CI 0.40-6.95). This association was independent of prechallenge antibody levels, demographics, season of the year, body mass index, psychological variables, and health practices. Sleep fragmentation was unrelated to cold susceptibility. Other sleep variables obtained using diary and actigraphy were not strong predictors of cold susceptibility. Shorter sleep duration, measured behaviorally using actigraphy prior to viral exposure, was associated with increased susceptibility to the common cold. © 2015 Associated Professional Sleep Societies, LLC.

  18. The Babinski sign--a critical review.

    Science.gov (United States)

    Kumar, S P

    2003-01-01

    In 1896, Josph Babinski, a French neurologist, first described the best known neurologic eponym--"the Babinski sign". This sign is characterised by dorsiflexion of the big toe, by recruitment of the extensor hallucis longus muscle, on stimulating the sole of the foot. He himself emphasised from the outset the intimate relationship between this sign and the shortening movement in other leg muscles, which forms the flexion synergy of the lower limb. The Babinski sign is not a new reflex, rather it is released as a result of breakdown of the harmonious integration of the flexion and extension component of the normal defence reflex mechanism, due to pyramidal tract dysfunction. A pathological Babinski sign should be clearly distinguished from upgoing toes that may not always be a part of the flexion synergy. This article reviews the Babinski sign in detail, focusing on the historical perspectives, role of pyramidal tract dysfunction, art of elicitation and interpretation. The significance of assessing this phenomenon in the entire leg and the clinical clues that will help to dispel the myths regarding the Babinski sign has been emphasized.

  19. Quantitative susceptibility mapping of small objects using volume constraints.

    Science.gov (United States)

    Liu, Saifeng; Neelavalli, Jaladhar; Cheng, Yu-Chung N; Tang, Jin; Mark Haacke, E

    2013-03-01

    Microbleeds have been implicated to play a role in many neurovascular and neurodegenerative diseases. The diameter of each microbleed has been used previously as a possible quantitative measure for grading microbleeds. We propose that magnetic susceptibility provides a new quantitative measure of extravasated blood. Recently, a Fourier-based method has been used that allows susceptibility quantification from phase images for any arbitrarily shaped structures. However, when very small objects, such as microbleeds, are considered, the accuracy of this susceptibility mapping method still remains to be evaluated. In this article, air bubbles and glass beads are taken as microbleed surrogates to evaluate the quantitative accuracy of the susceptibility mapping method. We show that when an object occupies only a few voxels, an estimate of the true volume of the object is necessary for accurate susceptibility quantification. Remnant errors in the quantified susceptibilities and their sources are evaluated. We show that quantifying magnetic moment, rather than the susceptibility of these small structures, may be a better and more robust alternative. Copyright © 2012 Wiley Periodicals, Inc.

  20. Waddell non-organic signs: new evidence suggests somatic amplification among outpatient chronic pain patients.

    Science.gov (United States)

    Wygant, Dustin B; Arbisi, Paul A; Bianchini, Kevin J; Umlauf, Robert L

    2017-04-01

    Waddell et al. identified a set of eight non-organic signs in 1980. There has been controversy about their meaning, particularly with respect to their use as validity indicators. The current study examined the Waddell signs in relation to measures of somatic amplification or over-reporting in a sample of outpatient chronic pain patients. We examined the degree to which these signs were associated with measures of over-reporting. This study examined scores on the Waddell signs in relation to over-reporting indicators in an outpatient chronic pain sample. We examined 230 chronic pain patients treated at a multidisciplinary pain clinic. The majority of these patients presented with primary back or spinal injuries. The outcome measures used in the study were Waddell signs, Modified Somatic Perception Questionnaire, Pain Disability Index, and the Minnesota Multiphasic Personality Inventory-2 Restructured Form. We examined Waddell signs using multivariate analysis of variance (MANOVA) and analysis of variance (ANOVA), receiver operating characteristic analysis, classification accuracy, and relative risk ratios. Multivariate analysis of variance and ANOVA showed a significant association between Waddell signs and somatic amplification. Classification analyses showed increased odds of somatic amplification at a Waddell score of 2 or 3. Our results found significant evidence of an association between Waddell signs and somatic over-reporting. Elevated scores on the Waddell signs (particularly scores higher than 2 and 3) were associated with increased odds of exhibiting somatic over-reporting. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. The Phonetics of Head and Body Movement in the Realization of American Sign Language Signs.

    Science.gov (United States)

    Tyrone, Martha E; Mauk, Claude E

    2016-01-01

    Because the primary articulators for sign languages are the hands, sign phonology and phonetics have focused mainly on them and treated other articulators as passive targets. However, there is abundant research on the role of nonmanual articulators in sign language grammar and prosody. The current study examines how hand and head/body movements are coordinated to realize phonetic targets. Kinematic data were collected from 5 deaf American Sign Language (ASL) signers to allow the analysis of movements of the hands, head and body during signing. In particular, we examine how the chin, forehead and torso move during the production of ASL signs at those three phonological locations. Our findings suggest that for signs with a lexical movement toward the head, the forehead and chin move to facilitate convergence with the hand. By comparison, the torso does not move to facilitate convergence with the hand for signs located at the torso. These results imply that the nonmanual articulators serve a phonetic as well as a grammatical or prosodic role in sign languages. Future models of sign phonetics and phonology should take into consideration the movements of the nonmanual articulators in the realization of signs. © 2016 S. Karger AG, Basel.

  2. How to estimate the signs' configuration in the directed signed social networks?

    Science.gov (United States)

    Guo, Long; Gao, Fujuan; Jiang, Jian

    2017-02-01

    Inspired by the ensemble theory in statistical mechanics, we introduce a reshuffling approach to empirical analyze signs' configuration in the directed signed social networks of Epinions and Slashdots. In our reshuffling approach, each negative link has the reshuffling probability prs to exchange its sign with another positive link chosen randomly. Many reshuffled networks with different signs' configuration are built under different prss. For each reshuffled network, the entropies of the self social status are calculated and the opinion formation of the majority-rule model is analyzed. We find that Souts reach their own minimum values and the order parameter |m* | reaches its maximum value in the networks of Epinions and Slashdots without the reshuffling operation. Namely, individuals share the homogeneous properties of self social status and dynamic status in the real directed signed social networks. Our present work provides some interesting tools and perspective to understand the signs' configuration in signed social networks, especially in the online affiliation networks.

  3. [Antibiotics susceptibility of Streptococcus and Enterococcus: data of Onerba network].

    Science.gov (United States)

    Vachée, A; Varon, E; Jouy, E; Meunier, D

    2009-05-01

    This work was aimed to analyze trends in susceptibility to antibiotics among the main species of beta-hemolytic streptococci involved in community-acquired infections in human (Streptococcus pyogenes and Streptococcus agalactiae), or in animals (Streptococcus suis and Streptococcus uberis) and also among the main enterocci species, Enterococcus faecalis and Enterococcus faecium. Data were recorded since 1996 through the Onerba networks. S. pyogenes, as the other beta-hemolytic streptococci studied remained fully susceptible to beta-lactam antibiotics. However, susceptibility to macrolides is clearly decreasing in S. pyogenes. In 2002, only 62 to 65% of the strains according to the network considered, were susceptible to erythromycin. A similar trend was observed for S. agalactiae with only 75% of erythromycin susceptibility in 2002, and for both species isolated from animals S. suis and S. uberis, with respectively 35 and 76% of strains susceptible to erythromycin. In enterococci, susceptibility to beta-lactams remained stable between 2000 and 2004. Indeed, the susceptibility to aminopenicillins remained high in E. faecalis (about 98%), whereas the proportion of E. faecium isolates susceptible to these antibiotics were lower than 60%. From 1999 to 2004, various studies conducted in French hospitals showed that the vancomycin resistance among enterococci accounted for less than 2%. However, the recent emergence of glycopeptide resistant enterococci clusters in French hospitals is a matter of concern and emphasizes the need for an ongoing surveillance. Such trend in macrolide resistance among S. pyogenes or S. agalactiae should consequently lead to propose other alternatives in case of beta-lactam allergy, and for pharyngitis, to rethink the place of the culture for susceptibility testing.

  4. The Babinski Sign: A comprehensive review.

    Science.gov (United States)

    Ambesh, Paurush; Paliwal, Vimal Kumar; Shetty, Vijay; Kamholz, Stephan

    2017-01-15

    The Babinski Sign is one of the most clinically relevant diagnostic signs in medicine. Though the plantar reflex is practiced thousands of times across the globe every day, few realize its historical importance. In this narrative review we trace the origins of the Plantar Reflex back in the 19th century, discuss its evolution over time and examine the body of evidence behind the current understanding. State of the art diagnostic modalities like video analysis and electromyography have helped us in dissecting the pathophysiology behind the simple yet beautiful Babinski Sign. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Entanglement susceptibility: area laws and beyond

    Science.gov (United States)

    Zanardi, Paolo; Campos Venuti, Lorenzo

    2013-04-01

    Generic quantum states in the Hilbert space of a many-body system are nearly maximally entangled whereas low-energy physical states are not; the so-called area laws for quantum entanglement are widespread. In this paper we introduce the novel concept of entanglement susceptibility by expanding the 2-Rényi entropy in the boundary couplings. We show how this concept leads to the emergence of area laws for bi-partite quantum entanglement in systems ruled by local gapped Hamiltonians. Entanglement susceptibility also captures quantitatively which violations one should expect when the system becomes gapless. We also discuss an exact series expansion of the 2-Rényi entanglement entropy in terms of connected correlation functions of a boundary term. This is obtained by identifying Rényi entropy with ground state fidelity in a doubled and twisted theory.

  6. The non- (existent) native signer: sign language research in a small deaf population

    NARCIS (Netherlands)

    Costello, B.; Fernández, J.; Landa, A.; Quadros, R.; Möller de Quadros,

    2008-01-01

    This paper examines the concept of a native language user and looks at the different definitions of native signer within the field of sign language research. A description of the deaf signing population in the Basque Country shows that the figure of 5-10% typically cited for deaf individuals born

  7. Type of iconicity matters in the vocabulary development of signing children

    NARCIS (Netherlands)

    Ortega, G.; Sümer, B.; Özyürek, A.

    2017-01-01

    Recent research on signed as well as spoken language shows that the iconic features of the target language might play a role in language development. Here, we ask further whether different types of iconic depictions modulate children's preferences for certain types of sign-referent links during

  8. Comprehending Sentences with the Body: Action Compatibility in British Sign Language?

    Science.gov (United States)

    Vinson, David; Perniss, Pamela; Fox, Neil; Vigliocco, Gabriella

    2017-01-01

    Previous studies show that reading sentences about actions leads to specific motor activity associated with actually performing those actions. We investigate how sign language input may modulate motor activation, using British Sign Language (BSL) sentences, some of which explicitly encode direction of motion, versus written English, where motion…

  9. Sign Language and Language Acquisition in Man and Ape. New Dimensions in Comparative Pedolinguistics.

    Science.gov (United States)

    Peng, Fred C. C., Ed.

    A collection of research materials on sign language and primatology is presented here. The essays attempt to show that: sign language is a legitimate language that can be learned not only by humans but by nonhuman primates as well, and nonhuman primates have the capability to acquire a human language using a different mode. The following…

  10. Computed tomography angiography spot sign predicts intraprocedural aneurysm rupture in subarachnoid hemorrhage.

    Science.gov (United States)

    Burkhardt, Jan-Karl; Neidert, Marian Christoph; Stienen, Martin Nikolaus; Schöni, Daniel; Fung, Christian; Roethlisberger, Michel; Corniola, Marco Vincenzo; Bervini, David; Maduri, Rodolfo; Valsecchi, Daniele; Tok, Sina; Schatlo, Bawarjan; Bijlenga, Philippe; Schaller, Karl; Bozinov, Oliver; Regli, Luca

    2017-07-01

    To analyze whether the computed tomography angiography (CTA) spot sign predicts the intraprocedural rupture rate and outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). From a prospective nationwide multicenter registry database, 1023 patients with aneurysmal subarachnoid hemorrhage (aSAH) were analyzed retrospectively. Descriptive statistics and logistic regression analysis were used to compare spot sign-positive and -negative patients with aneurysmal intracerebral hemorrhage (aICH) for baseline characteristics, aneurysmal and ICH imaging characteristics, treatment and admission status as well as outcome at discharge and 1-year follow-up (1YFU) using the modified Rankin Scale (mRS). A total of 218 out of 1023 aSAH patients (21%) presented with aICH including 23/218 (11%) patients with spot sign. Baseline characteristics were comparable between spot sign-positive and -negative patients. There was a higher clip-to-coil ratio in patients with than without aICH (both spot sign positive and negative). Median aICH volume was significantly higher in the spot sign-positive group (50 ml, 13-223 ml) than in the spot sign-negative group (18 ml, 1-416; p sign-positive aICH thus were three times as likely as those with spot sign-negative aICH to show an intraoperative aneurysm rupture [odds ratio (OR) 3.04, 95% confidence interval (CI) 1.04-8.92, p = 0.046]. Spot sign-positive aICH patients showed a significantly worse mRS at discharge (p = 0.039) than patients with spot sign-negative aICH (median mRS 5 vs. 4). Logistic regression analysis showed that the spot sign was an aICH volume-dependent predictor for outcome. Both spot sign-positive and -negative aICH patients showed comparable rates of hospital death, death at 1YFU and mRS at 1YFU. In this multicenter data analysis, patients with spot sign-positive aICH showed higher aICH volumes and a higher rate of intraprocedural aneurysm rupture, but comparable long-term outcome to spot sign-negative a

  11. Hey Teacher, Your Personality's Showing!

    Science.gov (United States)

    Paulsen, James R.

    1977-01-01

    A study of 30 fourth, fifth, and sixth grade teachers and 300 of their students showed that a teacher's age, sex, and years of experience did not relate to students' mathematics achievement, but that more effective teachers showed greater "freedom from defensive behavior" than did less effective teachers. (DT)

  12. Planning a Successful Tech Show

    Science.gov (United States)

    Nikirk, Martin

    2011-01-01

    Tech shows are a great way to introduce prospective students, parents, and local business and industry to a technology and engineering or career and technical education program. In addition to showcasing instructional programs, a tech show allows students to demonstrate their professionalism and skills, practice public presentations, and interact…

  13. Ebola (Ebola Virus Disease): Signs and Symptoms

    Science.gov (United States)

    ... Resources Videos Audio Infographics & Illustrations Factsheets Posters Virus Ecology Graphic Signs and Symptoms Recommend on Facebook Tweet ... Entire Infographic [PDF – 1 page] Related Links Case Definition for Ebola Virus Disease (EVD) Questions and Answers ...

  14. Naine objektistab meest / Fideelia-Signe Roots

    Index Scriptorium Estoniae

    Roots, Fideelia-Signe, 1976-

    2009-01-01

    Fideelia-Signe Roots Eesti Kunstiakadeemias 2009. a. kevadsemestril enda poolt läbi viidud valikainekursusest "Kunstiteose anatoomiast mehe anatoomiani", mis lõppes näitusega "Tõuseb / ei tõuse" Eesti Tervishoiumuuseumis, avatud 31. maini

  15. What Are the Warning Signs of Stroke?

    Science.gov (United States)

    ... Cardiovascular Conditions What Are the Warning Signs of Stroke? Brain tissue affected by blockage Stroke is the fifth leading cause of death in ... over 55 years old have more chance of stroke, and the risk gets greater as you get ...

  16. Warning Signs of Vision Problems in Children

    Science.gov (United States)

    ... However, vision problems such as a lazy eye (amblyopia) may have no warning signs, and your child ... of your pediatrician. There may be variations in treatment that your pediatrician may recommend based on individual ...

  17. 33 CFR 127.113 - Warning signs.

    Science.gov (United States)

    2010-07-01

    ... shore and the water; and (3) Have the following text: Warning Dangerous Cargo No Visitors No Smoking No Open Lights (b) Each letter in the words on the sign must be— (1) Block style; (2) Black on a white...

  18. knowledge about obstetric danger signs among preg

    African Journals Online (AJOL)

    user

    deficiencies in awareness should be addressed through maternal and child health services by designing an appro- .... during labor and child birth, and at least two out of at least nine danger signs ..... Impact of the SIAGA maternal and neonatal.

  19. CDC Vital Signs: Prescription Painkiller Overdoses (Methadone)

    Science.gov (United States)

    ... Vital Signs Current Issue Infographic Topics Covered Alcohol Antibiotic Resistance Cancer Cardiovascular Diseases Diseases & Conditions Food Safety ... MMWR Science Clips Prescription Painkiller Overdoses Use and Abuse of Methadone as a Painkiller Recommend on Facebook ...

  20. Rapid rise and decay in petition signing

    National Research Council Canada - National Science Library

    Yasseri, Taha; Hale, Scott A; Margetts, Helen Z

    2017-01-01

    .... Petition signing is an example of collective action which has gained in popularity with rising use of social media and provides such data for the whole population of petition signatories for a given platform...

  1. The Babinski sign and the pyramidal syndrome.

    Science.gov (United States)

    Van Gijn, J

    1978-01-01

    The presence or absence of a Babinski sign can be puzzling, but in the light of existing pathological studies it is more fruitful to consider which pyramidal tract fibres release it than whether they release it. This was investigated clinically, by looking for correlations with other reflex changes and with motor deficits in the leg. A survey of 50 patients with a unilateral Babinski sign and six patients who lacked it in spite of other pyramidal tract signs was supplemented with follow-up of the patients who had acute lesions. Appearance of the Bibinski sign proved to depend on the interaction of two factors: (1) activity (not necessarily hyperactivity) in the segmental pathways of the flexion synergy; (2) a motor deficit of the foot, in some cases consisting only in an impairment of rapid foot movements, and probably representing a disturbance of direct pyramidal tract projections to distal motoneurones. PMID:310447

  2. CDC Vital Signs: Teen Drinking and Driving

    Science.gov (United States)

    ... the number of teen passengers Never use a cell phone or text while driving Obey speed limits Get ... Vital Signs Issue: Drinking and Driving Among High School Students Aged ≥16 Years — United States, 1991-2011. ...

  3. Louisiana traffic sign inventory and management system.

    Science.gov (United States)

    2003-09-01

    The Louisiana Department of Transportation and Development (DOTD), like many state highway agencies in the United States, lacks a comprehensive system for inventorying and maintaining records of traffic signs. To address this problem, state highway d...

  4. Water Breaking: Understand This Sign of Labor

    Science.gov (United States)

    Healthy Lifestyle Labor and delivery, postpartum care Water breaking worries? Prepare yourself for childbirth by getting the facts about this important sign of labor. By Mayo Clinic Staff If you're ...

  5. Performance of pile supported sign structures : [brief].

    Science.gov (United States)

    2015-05-01

    Sign structures in Wisconsin are typically supported by drilled shaft foundations or spread : footing foundations. However, when the soil conditions are not suitable to be supported on : drilled shafts or spread footings, a group of piles could suppo...

  6. DC-SIGN Polymorphisms Associated with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users.

    Science.gov (United States)

    Steba, Gaby S; Koekkoek, Sylvie M; Vanhommerig, Joost W; Brinkman, Kees; Kwa, David; Van Der Meer, Jan T M; Prins, Maria; Berkhout, Ben; Tanck, Michael; Paxton, William A; Molenkamp, Richard; Schinkel, Janke

    2017-11-13

    We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with HCV susceptibility. An MSM and an IDU cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN SNPs -139, -871 and -939 correlate with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlate with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

  7. ANTIBIOTIC SUSCEPTIBILITY OF POTENTIALLY PROBIOTIC LACTOBACILLUS STRAINS

    Directory of Open Access Journals (Sweden)

    Junhua Han

    2015-09-01

    Full Text Available Susceptibility of 29 Lactobacilli to 13 antibiotics was assayed by paper disc diffusion method. Plasmids and gastrointestinal tolerance were detected. The relationship between plasmids andantibiotic resistance was discussed. The results showed that all of the strains were resistant to bacitracin, polymyxin B, kanamycin, and nalidixic acid. Many strains were relatively sensitive tochloramphenicol and tetracycline. Six strains contained plasmids and showed good gastrointestinal tolerance. β-lactam resistance gene blr was found in the plasmid of L. plantarum CICC 23180by PCR. The study will be helpful to promote the safety evaluation and development of potentially probiotic lactic acid bacteria.

  8. Malta to sign MOU with CERN

    CERN Multimedia

    2008-01-01

    In what can be described as a historic moment for Malta's scientific sector, Prime Minister Lawrence Gonzi will today sign a memorandum of understanding with CERN that will start off a long-term participation project for Maltese engineers and scientists in research and innovation projects. The Prime Minister left yesterday, accompanied by government officials and University of Malta representatives, to sign the memorandum of understanding and initiate a series of discussions about further collaboration.

  9. Signed Link Analysis in Social Media Networks

    OpenAIRE

    Beigi, Ghazaleh; Tang, Jiliang; Liu, Huan

    2016-01-01

    Numerous real-world relations can be represented by signed networks with positive links (e.g., trust) and negative links (e.g., distrust). Link analysis plays a crucial role in understanding the link formation and can advance various tasks in social network analysis such as link prediction. The majority of existing works on link analysis have focused on unsigned social networks. The existence of negative links determines that properties and principles of signed networks are substantially dist...

  10. Sign patterns of J-orthogonal matrices

    Czech Academy of Sciences Publication Activity Database

    Hall, F.J.; Li, Z.; Parnass, C.; Rozložník, Miroslav

    2017-01-01

    Roč. 5, č. 1 (2017), s. 225-241 ISSN 2300-7451 Institutional support: RVO:67985840 Keywords : G-matrix * J-orthogonal matrix * sign pattern matrix * sign patterns that allow J-orthogonality Subject RIV: BA - General Mathematics https://www.degruyter.com/view/j/spma.2017.5.issue-1/spma-2017-0016/spma-2017-0016. xml ?format=INT

  11. Hummingbird sign in progressive supranuclear palsy disease

    Directory of Open Access Journals (Sweden)

    Sanjay Pandey

    2012-01-01

    Full Text Available Progressive supranuclear palsy (PSP is characterized by slowness, rigidity, bradykinesia, repeated falls, downgaze limitation and dementia. Midbrain atrophy on magnetic resonance imaging is highly suggestive of PSP and is described as "hummingbird sign". This sign is very helpful in differentiating PSP patients from those with Parkinson′s disease. We hereby report a 72-year-old female case of PSP primarily diagnosed with Parkinson′s disease.

  12. Susceptibility Genes in Thyroid Autoimmunity

    Directory of Open Access Journals (Sweden)

    Yoshiyuki Ban

    2005-01-01

    Full Text Available The autoimmune thyroid diseases (AITD are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g. dietary iodine is believed to initiate the autoimmune response to thyroid antigens. Abundant epidemiological data, including family and twin studies, point to a strong genetic influence on the development of AITD. Various techniques have been employed to identify the genes contributing to the etiology of AITD, including candidate gene analysis and whole genome screening. These studies have enabled the identification of several loci (genetic regions that are linked with AITD, and in some of these loci, putative AITD susceptibility genes have been identified. Some of these genes/loci are unique to Graves' disease (GD and Hashimoto's thyroiditis (HT and some are common to both the diseases, indicating that there is a shared genetic susceptibility to GD and HT. The putative GD and HT susceptibility genes include both immune modifying genes (e.g. HLA, CTLA-4 and thyroid specific genes (e.g. TSHR, Tg. Most likely, these loci interact and their interactions may influence disease phenotype and severity.

  13. On the temporal dynamics of sign production: An ERP study in Catalan Sign Language (LSC).

    Science.gov (United States)

    Baus, Cristina; Costa, Albert

    2015-06-03

    This study investigates the temporal dynamics of sign production and how particular aspects of the signed modality influence the early stages of lexical access. To that end, we explored the electrophysiological correlates associated to sign frequency and iconicity in a picture signing task in a group of bimodal bilinguals. Moreover, a subset of the same participants was tested in the same task but naming the pictures instead. Our results revealed that both frequency and iconicity influenced lexical access in sign production. At the ERP level, iconicity effects originated very early in the course of signing (while absent in the spoken modality), suggesting a stronger activation of the semantic properties for iconic signs. Moreover, frequency effects were modulated by iconicity, suggesting that lexical access in signed language is determined by the iconic properties of the signs. These results support the idea that lexical access is sensitive to the same phenomena in word and sign production, but its time-course is modulated by particular aspects of the modality in which a lexical item will be finally articulated. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Risk Aversion in Game Shows

    DEFF Research Database (Denmark)

    Andersen, Steffen; Harrison, Glenn W.; Lau, Morten I.

    2008-01-01

    We review the use of behavior from television game shows to infer risk attitudes. These shows provide evidence when contestants are making decisions over very large stakes, and in a replicated, structured way. Inferences are generally confounded by the subjective assessment of skill in some games......, and the dynamic nature of the task in most games. We consider the game shows Card Sharks, Jeopardy!, Lingo, and finally Deal Or No Deal. We provide a detailed case study of the analyses of Deal Or No Deal, since it is suitable for inference about risk attitudes and has attracted considerable attention....

  15. Gesture, sign and language: The coming of age of sign language and gesture studies

    Science.gov (United States)

    Goldin-Meadow, Susan; Brentari, Diane

    2016-01-01

    How does sign language compare to gesture, on the one hand, and to spoken language on the other? At one time, sign was viewed as nothing more than a system of pictorial gestures with no linguistic structure. More recently, researchers have argued that sign is no different from spoken language with all of the same linguistic structures. The pendulum is currently swinging back toward the view that sign is gestural, or at least has gestural components. The goal of this review is to elucidate the relationships among sign language, gesture, and spoken language. We do so by taking a close look not only at how sign has been studied over the last 50 years, but also at how the spontaneous gestures that accompany speech have been studied. We come to the conclusion that signers gesture just as speakers do. Both produce imagistic gestures along with more categorical signs or words. Because, at the moment, it is difficult to tell where sign stops and where gesture begins, we suggest that sign should not be compared to speech alone, but should be compared to speech-plus-gesture. Although it might be easier (and, in some cases, preferable) to blur the distinction between sign and gesture, we argue that making a distinction between sign (or speech) and gesture is essential to predict certain types of learning, and allows us to understand the conditions under which gesture takes on properties of sign, and speech takes on properties of gesture. We end by calling for new technology that may help us better calibrate the borders between sign and gesture. PMID:26434499

  16. Signs and symptoms associated with digestive tract development.

    Science.gov (United States)

    Morais, Mauro Batista de

    2016-01-01

    To analyze the development and prevalence of gastrointestinal signs and symptoms associated with the development of the digestive tract, and to assess the measures aimed to reduce their negative impacts. Considering the scope and comprehensiveness of the subject, a systematic review of the literature was not carried out. The Medline database was used to identify references that would allow the analysis of the study topics. Infants frequently show several gastrointestinal signs and symptoms. These clinical manifestations can be part of gastrointestinal functional disorders such as infantile colic, infant regurgitation, and functional constipation. Allergy to cow's milk protein and gastroesophageal reflux disease are also causes of these clinical manifestations and represent an important and difficult differential diagnosis. The diseases that course with gastrointestinal signs and symptoms can have an impact on family dynamics and maternal emotional status, and may be associated with future problems in the child's life. Comprehensive pediatric care is essential for diagnosis and treatment. Maternal breastfeeding should always be maintained. Some special formulas can contribute to the control of clinical manifestations depending on the established diagnosis. During the normal development of the digestive tract, several gastrointestinal signs and symptoms may occur, usually resulting from functional gastrointestinal disorders, gastroesophageal reflux disease, and allergy to cow's milk protein. Breastfeeding should always be maintained. Copyright © 2016 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

  17. Signs and symptoms associated with digestive tract development

    Directory of Open Access Journals (Sweden)

    Mauro Batista de Morais

    2016-06-01

    Full Text Available ABSTRACT Objective: To analyze the development and prevalence of gastrointestinal signs and symptoms associated with the development of the digestive tract, and to assess the measures aimed to reduce their negative impacts. Source of data: Considering the scope and comprehensiveness of the subject, a systematic review of the literature was not carried out. The Medline database was used to identify references that would allow the analysis of the study topics. Synthesis of results: Infants frequently show several gastrointestinal signs and symptoms. These clinical manifestations can be part of gastrointestinal functional disorders such as infantile colic, infant regurgitation, and functional constipation. Allergy to cow's milk protein and gastroesophageal reflux disease are also causes of these clinical manifestations and represent an important and difficult differential diagnosis. The diseases that course with gastrointestinal signs and symptoms can have an impact on family dynamics and maternal emotional status, and may be associated with future problems in the child's life. Comprehensive pediatric care is essential for diagnosis and treatment. Maternal breastfeeding should always be maintained. Some special formulas can contribute to the control of clinical manifestations depending on the established diagnosis. Conclusion: During the normal development of the digestive tract, several gastrointestinal signs and symptoms may occur, usually resulting from functional gastrointestinal disorders, gastroesophageal reflux disease, and allergy to cow's milk protein. Breastfeeding should always be maintained.

  18. Individual variability in behavioral flexibility predicts sign-tracking tendency

    Directory of Open Access Journals (Sweden)

    Helen M Nasser

    2015-11-01

    Full Text Available Sign-tracking rats show heightened sensitivity to food- and drug-associated cues, which serve as strong incentives for driving reward seeking. We hypothesized that this enhanced incentive drive is accompanied by an inflexibility when incentive value changes. To examine this we tested rats in Pavlovian outcome devaluation or second-order conditioning prior to the assessment of sign-tracking tendency. To assess behavioral flexibility we trained rats to associate a light with a food outcome. After the food was devalued by pairing with illness, we measured conditioned responding to the light during an outcome devaluation probe test. The level of conditioned responding during outcome devaluation probe test correlated with the rats’ subsequent tracking tendency, with sign-tracking rats failing to suppress conditioned responding to the light after outcome devaluation. To assess Pavlovian incentive learning, we trained rats on first-order (CS+, CS- and second-order (SOCS+, SOCS- discriminations. After second-order conditioning, we measured conditioned responding to the second-order cues during a probe test. Second-order conditioning was observed in all rats regardless of tracking tendency. The behavioral inflexibility of sign-trackers has potential relevance for understanding individual variation in vulnerability to drug addiction.

  19. The reversed halo sign: update and differential diagnosis

    Science.gov (United States)

    Godoy, M C B; Viswanathan, C; Marchiori, E; Truong, M T; Benveniste, M F; Rossi, S; Marom, E M

    2012-01-01

    The reversed halo sign is characterised by a central ground-glass opacity surrounded by denser air–space consolidation in the shape of a crescent or a ring. It was first described on high-resolution CT as being specific for cryptogenic organising pneumonia. Since then, the reversed halo sign has been reported in association with a wide range of pulmonary diseases, including invasive pulmonary fungal infections, paracoccidioidomycosis, pneumocystis pneumonia, tuberculosis, community-acquired pneumonia, lymphomatoid granulomatosis, Wegener granulomatosis, lipoid pneumonia and sarcoidosis. It is also seen in pulmonary neoplasms and infarction, and following radiation therapy and radiofrequency ablation of pulmonary malignancies. In this article, we present the spectrum of neoplastic and non-neoplastic diseases that may show the reversed halo sign and offer helpful clues for assisting in the differential diagnosis. By integrating the patient's clinical history with the presence of the reversed halo sign and other accompanying radiological findings, the radiologist should be able to narrow the differential diagnosis substantially, and may be able to provide a presumptive final diagnosis, which may obviate the need for biopsy in selected cases, especially in the immunosuppressed population. PMID:22553298

  20. Hazardous sign detection for safety applications in traffic monitoring

    Science.gov (United States)

    Benesova, Wanda; Kottman, Michal; Sidla, Oliver

    2012-01-01

    The transportation of hazardous goods in public streets systems can pose severe safety threats in case of accidents. One of the solutions for these problems is an automatic detection and registration of vehicles which are marked with dangerous goods signs. We present a prototype system which can detect a trained set of signs in high resolution images under real-world conditions. This paper compares two different methods for the detection: bag of visual words (BoW) procedure and our approach presented as pairs of visual words with Hough voting. The results of an extended series of experiments are provided in this paper. The experiments show that the size of visual vocabulary is crucial and can significantly affect the recognition success rate. Different code-book sizes have been evaluated for this detection task. The best result of the first method BoW was 67% successfully recognized hazardous signs, whereas the second method proposed in this paper - pairs of visual words and Hough voting - reached 94% of correctly detected signs. The experiments are designed to verify the usability of the two proposed approaches in a real-world scenario.

  1. 36 CFR 1192.55 - Priority seating signs.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Priority seating signs. 1192... Rapid Rail Vehicles and Systems § 1192.55 Priority seating signs. (a) Each vehicle shall contain sign(s... passengers should make such seats available to those who wish to use them. (b) Characters on signs required...

  2. 36 CFR 1192.27 - Priority seating signs.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Priority seating signs. 1192... Buses, Vans and Systems § 1192.27 Priority seating signs. (a) Each vehicle shall contain sign(s) which... forward-facing seats shall be so designated. (b) Each securement location shall have a sign designating it...

  3. 36 CFR 1192.105 - Priority seating signs.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Priority seating signs. 1192... Commuter Rail Cars and Systems § 1192.105 Priority seating signs. (a) Each car shall contain sign(s) which... should make such seats available to those who wish to use them. (b) Characters on signs required by...

  4. Sign Language Echolalia in Deaf Children with Autism Spectrum Disorder

    Science.gov (United States)

    Shield, Aaron; Cooley, Frances; Meier, Richard P.

    2017-01-01

    Purpose: We present the first study of echolalia in deaf, signing children with autism spectrum disorder (ASD). We investigate the nature and prevalence of sign echolalia in native-signing children with ASD, the relationship between sign echolalia and receptive language, and potential modality differences between sign and speech. Method: Seventeen…

  5. Measuring performance at trade shows

    DEFF Research Database (Denmark)

    Hansen, Kåre

    2004-01-01

    Trade shows is an increasingly important marketing activity to many companies, but current measures of trade show performance do not adequately capture dimensions important to exhibitors. Based on the marketing literature's outcome and behavior-based control system taxonomy, a model is built...... that captures a outcome-based sales dimension and four behavior-based dimensions (i.e. information-gathering, relationship building, image building, and motivation activities). A 16-item instrument is developed for assessing exhibitors perceptions of their trade show performance. The paper presents evidence...... of the scale's reliability, factor structure, and validity on the basis of analyzing data from independent samples of exhibitors at the international trade shows SIAL (Paris) and ANUGA (Cologne); and it concludes with a discussion of potential managerial applications and implications for future research. New...

  6. The prevalence and significance of abnormal vital signs prior to in-hospital cardiac arrest.

    Science.gov (United States)

    Andersen, Lars W; Kim, Won Young; Chase, Maureen; Berg, Katherine M; Mortensen, Sharri J; Moskowitz, Ari; Novack, Victor; Cocchi, Michael N; Donnino, Michael W

    2016-01-01

    Patients suffering in-hospital cardiac arrest often show signs of physiological deterioration before the event. The purpose of this study was to determine the prevalence of abnormal vital signs 1-4h before cardiac arrest, and to evaluate the association between these vital sign abnormalities and in-hospital mortality. We included adults from the Get With the Guidelines(®)- Resuscitation registry with an in-hospital cardiac arrest. We used two a priori definitions for vital signs: abnormal (heart rate (HR) ≤ 60 or ≥ 100 min(-1), respiratory rate (RR) ≤ 10 or >20 min(-1) and systolic blood pressure (SBP) ≤ 90 mm Hg) and severely abnormal (HR ≤ 50 or ≥ 130 min(-1), RR ≤ 8 or ≥ 30 min(-1) and SBP ≤ 80 mm Hg). We evaluated the association between the number of abnormal vital signs and in-hospital mortality using a multivariable logistic regression model. 7851 patients were included. Individual vital signs were associated with in-hospital mortality. The majority of patients (59.4%) had at least one abnormal vital sign 1-4h before the arrest and 13.4% had at least one severely abnormal sign. We found a step-wise increase in mortality with increasing number of abnormal vital signs within the abnormal (odds ratio (OR) 1.53 (CI: 1.42-1.64) and severely abnormal groups (OR 1.62 (CI: 1.38-1.90)). This remained in multivariable analysis (abnormal: OR 1.38 (CI: 1.28-1.48), and severely abnormal: OR 1.40 (CI: 1.18-1.65)). Abnormal vital signs are prevalent 1-4h before in-hospital cardiac arrest on hospital wards. In-hospital mortality increases with increasing number of pre-arrest abnormal vital signs as well as increased severity of vital sign derangements. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. T1 bright appendix sign to exclude acute appendicitis in pregnant women.

    Science.gov (United States)

    Shin, Ilah; An, Chansik; Lim, Joon Seok; Kim, Myeong-Jin; Chung, Yong Eun

    2017-08-01

    To evaluate the diagnostic value of the T1 bright appendix sign for the diagnosis of acute appendicitis in pregnant women. This retrospective study included 125 pregnant women with suspected appendicitis who underwent magnetic resonance (MR) imaging. The T1 bright appendix sign was defined as a high intensity signal filling more than half length of the appendix on T1-weighted imaging. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the T1 bright appendix sign for normal appendix identification were calculated in all patients and in those with borderline-sized appendices (6-7 mm). The T1 bright appendix sign was seen in 51% of patients with normal appendices, but only in 4.5% of patients with acute appendicitis. The overall sensitivity, specificity, PPV, and NPV of the T1 bright appendix sign for normal appendix diagnosis were 44.9%, 95.5%, 97.6%, and 30.0%, respectively. All four patients with borderline sized appendix with appendicitis showed negative T1 bright appendix sign. The T1 bright appendix sign is a specific finding for the diagnosis of a normal appendix in pregnant women with suspected acute appendicitis. • Magnetic resonance imaging is increasingly used in emergency settings. • Acute appendicitis is the most common cause of acute abdomen. • Magnetic resonance imaging is widely used in pregnant population. • T1 bright appendix sign can be a specific sign representing normal appendix.

  8. DC-SIGN and Influenza Hemagglutinin Dynamics in Plasma Membrane Microdomains Are Markedly Different

    Science.gov (United States)

    Itano, Michelle S.; Neumann, Aaron K.; Liu, Ping; Zhang, Feng; Gratton, Enrico; Parak, Wolfgang J.; Thompson, Nancy L.; Jacobson, Ken

    2011-01-01

    DC-SIGN, a Ca2+-dependent transmembrane lectin, is found assembled in microdomains on the plasma membranes of dendritic cells. These microdomains bind a large variety of pathogens and facilitate their uptake for subsequent antigen presentation. In this study, DC-SIGN dynamics in microdomains were explored with several fluorescence microscopy methods and compared with dynamics for influenza hemagglutinin (HA), which is also found in plasma membrane microdomains. Fluorescence imaging indicated that DC-SIGN microdomains may contain other C-type lectins and that the DC-SIGN cytoplasmic region is not required for microdomain formation. Fluorescence recovery after photobleaching measurements showed that neither full-length nor cytoplasmically truncated DC-SIGN in microdomains appreciably exchanged with like molecules in other microdomains and the membrane surround, whereas HA in microdomains exchanged almost completely. Line-scan fluorescence correlation spectroscopy indicated an essentially undetectable lateral mobility for DC-SIGN but an appreciable mobility for HA within their respective domains. Single-particle tracking with defined-valency quantum dots confirmed that HA has significant mobility within microdomains, whereas DC-SIGN does not. By contrast, fluorescence recovery after photobleaching indicated that inner leaflet lipids are able to move through DC-SIGN microdomains. The surprising stability of DC-SIGN microdomains may reflect structural features that enhance pathogen uptake either by providing high-avidity platforms and/or by protecting against rapid microdomain endocytosis. PMID:21641311

  9. ERP correlates of German Sign Language processing in deaf native signers.

    Science.gov (United States)

    Hänel-Faulhaber, Barbara; Skotara, Nils; Kügow, Monique; Salden, Uta; Bottari, Davide; Röder, Brigitte

    2014-05-10

    The present study investigated the neural correlates of sign language processing of Deaf people who had learned German Sign Language (Deutsche Gebärdensprache, DGS) from their Deaf parents as their first language. Correct and incorrect signed sentences were presented sign by sign on a computer screen. At the end of each sentence the participants had to judge whether or not the sentence was an appropriate DGS sentence. Two types of violations were introduced: (1) semantically incorrect sentences containing a selectional restriction violation (implausible object); (2) morphosyntactically incorrect sentences containing a verb that was incorrectly inflected (i.e., incorrect direction of movement). Event-related brain potentials (ERPs) were recorded from 74 scalp electrodes. Semantic violations (implausible signs) elicited an N400 effect followed by a positivity. Sentences with a morphosyntactic violation (verb agreement violation) elicited a negativity followed by a broad centro-parietal positivity. ERP correlates of semantic and morphosyntactic aspects of DGS clearly differed from each other and showed a number of similarities with those observed in other signed and oral languages. These data suggest a similar functional organization of signed and oral languages despite the visual-spacial modality of sign language.

  10. Neurological Soft Signs in Obsessive Compulsive Disorder: Standardised Assessment and Comparison with Schizophrenia

    Directory of Open Access Journals (Sweden)

    D. Bolton

    1999-01-01

    Full Text Available While several studies have detected raised levels of neurological soft signs in patients with obsessive compulsive disorder (OCD, the specificity of these abnormalities remains uncertain. This study used a new standardised measure, the Cambridge Neurological Inventory (CNI, to assess soft signs in 51 subjects with OCD. Comparison was made with data on patients with schizophrenia and a non-clinical control group from a previously reported study. Individuals with OCD showed raised levels of soft signs compared with non-clinical controls in many categories of the CNI: Motor Coordination, Sensory Integration, Primitive Reflexes, Extrapyramidal Signs, and Failure of Suppression. Compared with patients with schizophrenia, the OCD group had lower levels of neurological signs in some CNI categories: Hard Signs, Motor Co-ordination, Tardive Dyskinesia, Catatonic Signs, and Extrapyramidal Signs. However, levels of soft signs in the OCD group did not significantly differ from those in the schizophrenia group in other CNI categories: Sensory Integration, Primitive Reflexes and Failure of Suppression. The significance of these patterns of findings is discussed.

  11. Dromedaries (Camelus dromedarius) are of Low Susceptibility to Inoculation with Foot-and-Mouth Disease Virus Serotype O

    DEFF Research Database (Denmark)

    Alexandersen, Søren; Wernery, U.; Nagy, P.

    2008-01-01

    Two sheep and five dromedaries were inoculated with a highdose of a cattle-passaged type O strain of foot-and-mouth disease virus (FMDV). The sheep developed typical FMD. The inoculated camels, which were placed in contact with five further dromedaries and four sheep, showed no visible sign...... the contact-exposed camels and sheep and two of the inoculated camels were serologically negative for FMD when tested up to day 28. In contrast, the camel with viraemia became serologically positive front day 14, and the other two inoculated camels (which had been exposed to FMDV in an earlier experiment......) became serologically positive from day 10. The experiment suggested that dromedaries (1) are of low susceptibility to FMDV serotype O, (2) do not transmit infection, even by close contact, and (3) are Unlikely to play a significant epidemiological role in FMD....

  12. Magnetic compensation-induced sign reversal of exchange bias in a multi-glass perovskite SmFeO3

    Science.gov (United States)

    De, Chandan; Nayak, Ajaya K.; Nicklas, Michael; Sundaresan, A.

    2017-10-01

    We report an unusual sign reversal of exchange bias (EB) across a magnetic compensation point in an orthorhombic perovskite SmFeO3. A conventional negative EB with a positive vertical magnetization shift is observed below a cluster-glass freezing temperature (Tg ˜ 150 K). Upon further lowering of the temperature, the EB disappears at the magnetic compensation point before reversing its sign to a positive exchange bias below 4 K. The EB effect originates from an interfacial exchange interaction within a cluster glass phase, whereas its sign reversal arises from the reversal of the direction of the net magnetic moment as a result of dominance of Sm3+ over Fe3+ below the compensation temperature. The existence of a multi-glass state is demonstrated by ac-susceptibility and electrical permittivity measurements. A phenomenological model is presented to understand the EB effect and its sign reversal across the compensation point.

  13. Evaluation of overhead guide sign sheeting materials to increase visibility and safety for drivers.

    Science.gov (United States)

    Obeidat, Mohammed Said; Rys, Malgorzata J; Rys, Andrew; Du, Juan

    2016-09-01

    Overhead guide sign visibility must increase to improve driver safety on roadways. Two methods increase overhead guide sign visibility: sign illumination and use of retroreflective sheeting materials. This paper compares three types of retroreflective sheeting: Engineering Grade (type I), Diamond Grade (type XI), and High Intensity (type IV). A field experiment was conducted at night using licensed drivers to determine the optimum retroreflective sheeting material that increases sign visibility and legibility. Results showed that, of the three types of retroreflective sheeting, Diamond Grade (type XI) sheeting requires minimum illuminance to be visible, followed by High Intensity (type IV) sheeting. Cost analysis, including labor, maintenance, and material cost components of the three retroreflective sheeting materials, showed that High Intensity (type IV) could increase sign visibility and legibility at night for Departments of Transportation with limited budgets, consequently increasing driver safety on roadways. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Sequencing of DC-SIGN promoter indicates an association between promoter variation and risk of nasopharyngeal carcinoma in cantonese

    Directory of Open Access Journals (Sweden)

    Liu Wen-Sheng

    2010-11-01

    Full Text Available Abstract Background The dendritic cell-specific intercellular adhesion molecule 3 grabbing non-integrin (DC-SIGN is an important pathogen recognition receptor of the innate immune system. DC-SIGN promoter variants play important role in the susceptibility to various infectious diseases. Nasopharyngeal carcinoma (NPC is a malignancy that is common in southern China and whether DC-SIGN promoter variants have effects on susceptibility to NPC is still unknown. The aim of this study is to ascertain the potential involvement of DC-SIGN promoter single nucleotide polymorphisms (SNPs in NPC susceptibility. Methods We conducted a case control study based on Cantonese population including 444 NPC patients and 464 controls matched on age and sex. The 1041 bp of DC-SIGN promoter region was directly sequenced for all samples. Sequence alignment and SNP search were inspected using DNAStar analysis programs and haplotype frequencies were estimated in Haploview V 4.0. The associations between the SNPs and the risk of NPC were analyzed using chi-square test and non-conditional logistic regression analysis with SPSS 13.0 software. Results A total of six variants were observed in the DC-SIGN promoter region and DC-SIGN -139 GG and -939 AA were significantly associated with NPC risk with adjusted Odds Ratios (ORs of 2.10 (95% confidence interval [CI] = 1.23-3.59; P = 0.006 and 2.52 (1.29-4.93; P = 0.007 respectively and subjects carrying the risk allele DC-SIGN -871 G had 1.47-fold (95% CI = 1.14-1.90 increased risks of developing NPC (P = 0.003. Haplotype analysis revealed that h1 'AAAG' was significantly associated with protection against NPC (OR = 0.69; P = 0.0002 and the association was still significant when using 1000 permutation test runs (P = 0.001. Conclusions Our study indicated that DC-SIGN promoter variants appear to be involved in the susceptibility to NPC and the detailed mechanism of this effect need further studies.

  15. Towards first principle medical diagnostics: on the importance of disease-disease and sign-sign interactions

    Science.gov (United States)

    Ramezanpour, Abolfazl; Mashaghi, Alireza

    2017-07-01

    A fundamental problem in medicine and biology is to assign states, e.g. healthy or diseased, to cells, organs or individuals. State assignment or making a diagnosis is often a nontrivial and challenging process and, with the advent of omics technologies, the diagnostic challenge is becoming more and more serious. The challenge lies not only in the increasing number of measured properties and dynamics of the system (e.g. cell or human body) but also in the co-evolution of multiple states and overlapping properties, and degeneracy of states. We develop, from first principles, a generic rational framework for state assignment in cell biology and medicine, and demonstrate its applicability with a few simple theoretical case studies from medical diagnostics. We show how disease-related statistical information can be used to build a comprehensive model that includes the relevant dependencies between clinical and laboratory findings (signs) and diseases. In particular, we include disease-disease and sign-sign interactions and study how one can infer the probability of a disease in a patient with given signs. We perform comparative analysis with simple benchmark models to check the performances of our models. We find that including interactions can significantly change the statistical importance of the signs and diseases. This first principles approach, as we show, facilitates the early diagnosis of disease by taking interactions into accounts, and enables the construction of consensus diagnostic flow charts. Additionally, we envision that our approach will find applications in systems biology, and in particular, in characterizing the phenome via the metabolome, the proteome, the transcriptome, and the genome.

  16. Inherited susceptibility and radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    Little, J.B. [Harvard School of Public Health, Boston, MA (United States)

    1997-03-01

    There is continuing concern that some people in the general population may have genetic makeups that place them at particularly high risk for radiation-induced cancer. The existence of such a susceptible subpopulation would have obvious implications for the estimation of risks of radiation exposure. Although it has been long known that familial aggregations of cancer do sometimes occur, recent evidence suggests that a general genetic predisposition to cancer does not exist; most cancers occur sporadically. On the other hand, nearly 10% of the known Mendelian genetic disorders are associated with cancer. A number of these involve a familial predisposition to cancer, and some are characterized by an enhanced susceptibility to the induction of cancer by various physical and chemical carcinogens, including ionizing radiation. Such increased susceptibility will depend on several factors including the frequency of the susceptibility gene in the population and its penetrance, the strength of the predisposition, and the degree to which the cancer incidence in susceptible individuals may be increased by the carcinogen. It is now known that these cancer-predisposing genes may be responsible not only for rare familial cancer syndromes, but also for a proportion of the common cancers. Although the currently known disorders can account for only a small fraction of all cancers, they serve as models for genetic predisposition to carcinogen-induced cancer in the general population. In the present report, the author describes current knowledge of those specific disorders that are associated with an enhanced predisposition to radiation-induced cancer, and discusses how this knowledge may bear on the susceptibility to radiation-induced cancer in the general population and estimates of the risk of radiation exposure.

  17. Post Traumatic Tension Pneumocephalus: The Mount Fuji Sign

    LENUS (Irish Health Repository)

    Ryan, J

    2017-04-01

    Pneumocephalus is defined as the presence of intracranial air. This is most commonly secondary to a traumatic head injury. Tension pneumocephalus presents radiologically with compression of the frontal lobes and widening of the interhemispheric space between the frontal lobes. It is often termed the Mount Fuji sign due to a perceived similarity with an iconic mountain peak in Japan. We present the case of a 52-year-old gentleman who presented to the emergency department shortly before 8am on a Saturday morning following an assault. He was alert and ambulatory with no clinical evidence of raised intracranial pressure. A plain radiograph of the facial bones showed significant pneumocephalus. A later CT was consistent with a tension pneumocephalus which usually necessitates urgent decompression.The patient showed no clinical signs or symptoms of raised intracranial pressure and was managed conservatively. He was discharged home 16 days later with no neurological deficit

  18. pitting corrosion susceptibility pitting corrosion susceptibility of aisi ...

    African Journals Online (AJOL)

    eobe

    Abstract. The susceptibility of austenitic (AISI 301) stainless steel to pitting corrosion was evaluated in sodium chloride. (NaCl) solutions ... AISI 301 steel suffers from pitting corrosion in all the investigated solutions. AISI 301 steel suffers from ..... [1] Ijeomah, M.N.C. Elements of Corrosion and Protection. Theory, Auto Century ...

  19. Magnetic Susceptability Measurements in Superconductors

    Science.gov (United States)

    Kim, Jason; Mallory, Kendall; Seim, Ryan

    2000-04-01

    A new undergraduate research facility in magnetic susceptability measurements on superconductors is being developed at the University of Northern Colorado. Initial data measurements of the magnetic susceptability of various superconductors will be presented. These measurements were obtained with a liquid helium/nitrogen dewar that was reassembled for use in this project. The cryostat consists of two separate dewars, the first of which contains liquid nitrogen, the second, liquid helium. The liquid nitrogen dewar is used to keep the helium bath from evaporating off too quickly. Data on the evaporation rates of the two liquids will also be presented.

  20. COMPARATIVE ANALYSIS OF THE STRUCTURE OF THE AMERICAN AND MACEDONIAN SIGN LANGUAGE

    Directory of Open Access Journals (Sweden)

    Aleksandra KAROVSKA RISTOVSKA

    2014-09-01

    Full Text Available Aleksandra Karovska Ristovska, M.A. in special education and rehabilitation sciences, defended her doctoral thesis on 9 of March 2014 at the Institute of Special Education and Rehabilitation, Faculty of Philosophy, University “Ss. Cyril and Methodius”- Skopje in front of the commission composed of: Prof. Zora Jachova, PhD; Prof. Jasmina Kovachevikj, PhD; Prof. Ljudmil Spasov, PhD; Prof. Goran Ajdinski, PhD; Prof. Daniela Dimitrova Radojicikj, PhD. The Macedonian Sign Language is a natural language, used by the community of Deaf in the Republic of Macedonia. This doctoral paper aimed towards the analyses of the characteristics of the Macedonian Sign Language: its phonology, morphology and syntax as well as towards the comparison of the Macedonian and the American Sign Language. William Stokoe was the first one who in the 1960’s started the research of the American Sign Language. He set the base of the linguistic research in sign languages. The analysis of the signs in the Macedonian Sign Language was made according Stokoe’s parameters: location, hand shape and movement. Lexicostatistics showed that MSL and ASL belong to a different language family. Beside this fact, they share some iconic signs, whose presence can be attributed to the phenomena of lexical borrowings. Phonologically, in ASL and MSL, if we make a change of one of Stokoe’s categories, the meaning of the word changes as well. Non-manual signs which are grammatical markers in sign languages are identical in ASL and MSL. The production of compounds and the production of plural forms are identical in both sign languages. The inflection of verbs is also identical. The research showed that the most common order of words in ASL and MSL is the SVO order (subject-verb-object, while the SOV and OVS order can seldom be met. Questions and negative sentences are produced identically in ASL and MSL.

  1. Repetitions in French Belgian Sign Language (LSFB) and Flemish Sign Language (VGT) narratives and conversations

    OpenAIRE

    Notarrigo, Ingrid; Meurant, Laurence; Van Herreweghe, Mieke; Vermeerbergen, Myriam

    2016-01-01

    Repetition was described in the nineties by a limited number of sign linguists: Vermeerbergen & De Vriendt (1994) looked at a small corpus of VGT data, Fisher & Janis (1990) analysed “verb sandwiches” in ASL and Pinsonneault (1994) “verb echos” in Quebec Sign Language. More recently the same phenomenon has been the focus of research in a growing number of signed languages, including American (Nunes and de Quadros 2008), Hong Kong (Sze 2008), Russian (Shamaro 2008), Polish (Flilipczak and Most...

  2. Adaptation of a Vocabulary Test from British Sign Language to American Sign Language

    OpenAIRE

    Mann, W.; Roy, P.; Morgan, G.

    2016-01-01

    This study describes the adaptation process of a vocabulary knowledge test for British Sign Language (BSL) into American Sign Language (ASL) and presents results from the first round of pilot testing with twenty deaf native ASL signers. The web-based test assesses the strength of deaf children’s vocabulary knowledge by means of different mappings of phonological form and meaning of signs. The adaptation from BSL to ASL involved nine stages, which included forming a panel of deaf/hearing exper...

  3. Tokyo Motor Show 2003; Tokyo Motor Show 2003

    Energy Technology Data Exchange (ETDEWEB)

    Joly, E.

    2004-01-01

    The text which follows present the different techniques exposed during the 37. Tokyo Motor Show. The report points out the great tendencies of developments of the Japanese automobile industry. The hybrid electric-powered vehicles or those equipped with fuel cells have been highlighted by the Japanese manufacturers which allow considerable budgets in the research of less polluting vehicles. The exposed models, although being all different according to the manufacturer, use always a hybrid system: fuel cell/battery. The manufacturers have stressed too on the intelligent systems for navigation and safety as well as on the design and comfort. (O.M.)

  4. High-efficient search and analysis of road signs

    Directory of Open Access Journals (Sweden)

    Дмитрий Александрович Морозов

    2015-12-01

    Full Text Available It is developed high-efficient algorithm for search and analysis of road signs. The work is based on the results of reviewing existing sources which describe given problem. There are described the most common steps in algorithm logic. There is designed, implemented and tested special program, which works on given algorithm. The results of testing show good recognition quality. Such program can be used as a part of driver assistance systems

  5. Seizure ending signs in patients with dyscognitive focal seizures.

    Science.gov (United States)

    Gavvala, Jay R; Gerard, Elizabeth E; Macken, Mícheál; Schuele, Stephan U

    2015-09-01

    Signs indicating the end of a focal seizure with loss of awareness and/or responsiveness but without progression to focal or generalized motor symptoms are poorly defined and can be difficult to determine. Not recognizing the transition from ictal to postictal behaviour can affect seizure reporting accuracy by family members and may lead to delayed or a lack of examination during EEG monitoring, erroneous seizure localization and inadequate medical intervention for prolonged seizure duration. Our epilepsy monitoring unit database was searched for focal seizures without secondary generalization for the period from 2007 to 2011. The first focal seizure in a patient with loss of awareness and/or responsiveness and/or behavioural arrest, with or without automatisms, was included. Seizures without objective symptoms or inadequate video-EEG quality were excluded. A total of 67 patients were included, with an average age of 41.7 years. Thirty-six of the patients had seizures from the left hemisphere and 29 from the right. All patients showed an abrupt change in motor activity and resumed contact with the environment as a sign of clinical seizure ending. Specific ending signs (nose wiping, coughing, sighing, throat clearing, or laughter) were seen in 23 of 47 of temporal lobe seizures and 7 of 20 extra-temporal seizures. Seizure ending signs are often subtle and the most common finding is a sudden change in motor activity and resumption of contact with the environment. More distinct signs, such as nose wiping, coughing or throat clearing, are not specific to temporal lobe onset. A higher proportion of seizures during sleep went unexamined, compared to those during wakefulness. This demonstrates that seizure semiology can be very subtle and arousals from sleep during monitoring should alert staff. Patient accounts of seizure frequency appear to be unreliable and witness reports need to be taken into account. [Published with video sequences].

  6. Adapting the Assessing British Sign Language Development: Receptive Skills Test into American sign language.

    Science.gov (United States)

    Enns, Charlotte J; Herman, Rosalind C

    2011-01-01

    Signed languages continue to be a key element of deaf education programs that incorporate a bilingual approach to teaching and learning. In order to monitor the success of bilingual deaf education programs, and in particular to monitor the progress of children acquiring signed language, it is essential to develop an assessment tool of signed language skills. Although researchers have developed some checklists and experimental tests related to American Sign Language (ASL) assessment, at this time a standardized measure of ASL does not exist. There have been tests developed in other signed languages, for example, British Sign Language, that can serve as models in this area. The purpose of this study was to adapt the Assessing British Sign Language Development: Receptive Skills Test for use in ASL in order to begin the process of developing a standardized measure of ASL skills. The results suggest that collaboration between researchers in different signed languages can provide a valuable contribution toward filling the gap in the area of signed language assessment. © The Author 2011. Published by Oxford University Press. All rights reserved.

  7. On the System of Place Name Signs in Estonian Sign Language

    Directory of Open Access Journals (Sweden)

    Liina Paales

    2011-05-01

    Full Text Available A place name sign is a linguistic-cultural marker that includes both memory and landscape. The author regards toponymic signs in Estonian Sign Language as representations of images held by the Estonian Deaf community: they reflect the geographical place, the period, the relationships of the Deaf community with hearing community, and the common and distinguishing features of the two cultures perceived by community's members. Name signs represent an element of signlore, which includes various types of creative linguistic play. There are stories hidden behind the place name signs that reveal the etymological origin of place name signs and reflect the community's memory. The purpose of this article is twofold. Firstly, it aims to introduce Estonian place name signs as Deaf signlore forms, analyse their structure and specify the main formation methods. Secondly, it interprets place-denoting signs in the light of understanding the foundations of Estonian Sign Language, Estonian Deaf education and education history, the traditions of local Deaf communities, and also of the cultural and local traditions of the dominant hearing communities. Both perspectives - linguistic and folkloristic - are represented in the current article.

  8. On the System of Place Name Signs in Estonian Sign Language

    Directory of Open Access Journals (Sweden)

    Liina Paales

    2010-12-01

    Full Text Available A place name sign is a linguistic-cultural marker that includes both memory and landscape. The author regards toponymic signs in Estonian Sign Language as representations of images held by the Estonian Deaf community: they reflect the geographical place, the period, the relationships of the Deaf community with hearing community, and the common and distinguishing features of the two cultures perceived by community's members. Name signs represent an element of signlore, which includes various types of creative linguistic play. There are stories hidden behind the place name signs that reveal the etymological origin of place name signs and reflect the community's memory. The purpose of this article is twofold. Firstly, it aims to introduce Estonian place name signs as Deaf signlore forms, analyse their structure and specify the main formation methods. Secondly, it interprets place-denoting signs in the light of understanding the foundations of Estonian Sign Language, Estonian Deaf education and education history, the traditions of local Deaf communities, and also of the cultural and local traditions of the dominant hearing communities. Both perspectives - linguistic and folkloristic - are represented in the current article.

  9. Complex sentences in sign languages: Modality, typology, discourse

    NARCIS (Netherlands)

    Pfau, R.; Steinbach, M.; Pfau, R.; Steinbach, M.; Herrmann, A.

    2016-01-01

    Sign language grammars, just like spoken language grammars, generally provide various means to generate different kinds of complex syntactic structures including subordination of complement clauses, adverbial clauses, or relative clauses. Studies on various sign languages have revealed that sign

  10. Warning Signs of Heart Attack, Stroke and Cardiac Arrest

    Science.gov (United States)

    ... Heart Attack WARNING SIGNS OF HEART ATTACK, STROKE & CARDIAC ARREST HEART ATTACK WARNING SIGNS CHEST DISCOMFORT Most heart ... to the hospital immediately. Learn more about stroke CARDIAC ARREST WARNING SIGNS SUDDEN LOSS OF RESPONSIVENESS No response ...

  11. Know Stroke: Know the Signs, Act in Time Video

    Medline Plus

    Full Text Available ... Seeing. Trouble Walking. Know Stroke, Know the Signs, Act in Time. Announcer: Most people know what to ... but you need to know the signs and act in time. Here are the signs to look ...

  12. Know Stroke: Know the Signs, Act in Time Video

    Medline Plus

    Full Text Available ... Trouble Seeing. Trouble Walking. Know Stroke, Know the Signs, Act in Time. Announcer: Most people know what ... a stroke, but you need to know the signs and act in time. Here are the signs ...

  13. Relationships of Un and Gi seasons of birth to clinical symptoms and signs.

    Science.gov (United States)

    Park, Young-Jae; Kim, Tae-Hee; Jin, Seng-Hee; Park, Young-Bae

    2013-03-01

    Season of birth (SOB) is a medical term used to describe the relationship between the season in which one is born and his or her physiologic and pathological characteristics. In East Asian medicine, the Un-Gi SOB is based on the Yin-yang-Five Phases theory. The purpose of this study is to examine the relationship between Un-Gi SOB and a multitude of clinical symptoms and signs, and to examine which of the Un and Gi seasons has the greatest impact on these symptoms and signs. Using the Delphi method, three Un-Gi experts formulated a 26-item questionnaire consisting of clinical symptoms and signs, with each item rated on a Likert 7-point scale. A total of 1057 Korean adolescents (583 males, 474 females) completed the 26-item questionnaire. After identifying the Un and Gi seasons of all subjects, item scores were evaluated to determine whether there was a difference between Un and Gi seasons. For Un seasons, males born in the Wood season had greater indigestion and were less physically active, whereas females born in the Earth season were better able to concentrate but had slower rates of growth. For Gi seasons, males born in the Fire season had greater indigestion and morning fatigue, and males born in the Earth season had higher tension. There was no relationship between symptoms, signs, and the Gi SOB in females. This indicates that males born in Wood Un and Gi seasons are susceptible to Earth-related clinical problems, whereas females born in the Earth Un season are susceptible to Earth-related clinical problems. The study results suggest that Un-Gi seasons based on the Yin-yang-Five Phases are related to clinical symptoms and signs, with significant differences between genders.

  14. Precise measurements of diamagnetic susceptibility of benzophenone and paraffin by using a magnetic levitation technique

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, K; Mogi, I; Awaji, S; Watanabe, K [High Field Laboratory for Superconducting Materials, Institute of Materials Research, Tohoku University, Sendai, 980-8577 (Japan)], E-mail: kohki@imr.tohoku.ac.jp

    2009-03-01

    Measurements for temperature dependence of diamagnetic susceptibility were performed under the magnetic levitation condition. The magnetic susceptibility of a single crystal of benzophenone showed monotonous decrease toward to the melting point with increasing temperature. The minimum change of the susceptibility was detected by 1.4 x 10{sup -12} m{sup 3}/kg. On the contrary, slight increase was observed below the melting point in the case of paraffin. The susceptibility of a paraffin melt was found to be smaller than that of the solid state. It was demonstrated that the magnetic levitation enables sensitive and contactless measurements of the diamagnetic susceptibility across the melting point.

  15. Local magnetic susceptibility in rare-earth compounds

    CERN Document Server

    Shiozawa, H; Obu, K

    2003-01-01

    The element specific magnetic susceptibilities of some rare-earth compounds are estimated by measuring magnetic circular dichroism at rare-earth M sub 4 sub , sub 5 absorption edges. The temperature dependences of the rare-earth 4f local magnetic susceptibilities in dense Kondo materials, CeNi, CeSn sub 3 and CeRu sub 4 Sb sub 1 sub 2 , are remarkably different from those of the bulk magnetic susceptibilities measured by a conventional magnetometer, although the 4f electron is regarded to mainly hold the magnetic moment in these compounds. In contrast, the rare-earth 4f local magnetic susceptibility of ferromagnetic NdFe sub 4 P sub 1 sub 2 shows almost as similar behavior as the bulk one.

  16. ARSENIC - SUSCEPTIBILITY & IN UTERO EFFECTS

    Science.gov (United States)

    Exposure to inorganic arsenic remains a serious public health problem at many locations worldwide. If has often been noted that prevalences of signs and symptoms of chronic arsenic poisoning differ among various populations. For example, skin lesions or peripheral vascular dis...

  17. Reality show: um paradoxo nietzschiano

    Directory of Open Access Journals (Sweden)

    Ilana Feldman

    2011-01-01

    Full Text Available

    O fenômeno dos reality shows - e a subseqüente relação entre imagem e verdade - assenta-se sobre uma série de paradoxos. Tais paradoxos podem ser compreendidos à luz do pensamento do filósofo alemão Friedrich Nietzsche, que, através dos usos de formulações paradoxais, concebia a realidade como um mundo de pura aparência e a verdade como um acréscimo ficcional, como um efeito. A ficção é então tomada, na filosofia de Nietzsche, não em seu aspecto falsificante e desrealizador - como sempre pleiteou nossa tradição metafísica -, mas como condição necessária para que certa espécie de invenção possa operar como verdade. Sendo assim, a própria expressão reality show, através de sua formulação paradoxal, engendra explicitamente um mundo de pura aparência, em que a verdade, a parte reality da proposição, é da ordem do suplemento, daquilo que se acrescenta ficcionalmente - como um adjetivo - a show. O ornamento, nesse caso, passa a ocupar o lugar central, apontando para o efeito produzido: o efeito-de-verdade. Seguindo, então, o pensamento nietzschiano e sua atualização na contemporaneidade, investigaremos de que forma os televisivos “shows de realidade” operam paradoxalmente, em consonância com nossas paradoxais práticas culturais.

  18. A Flexible Vital Sign Representation Framework for Mobile Healthcare

    OpenAIRE

    Mei, H.; Widya, I.A.; van Halteren, Aart; Erfianto, Bayu

    2007-01-01

    This paper proposes a framework for patient’s vital sign representations. This framework offers the flexibility to extend or to augment represented vital signs, e.g. with trend signs or professional’s annotations. It further enables multi standard representations of vital signs and meta-level information for processing of represented vital signs. Vital signs represented in accordance with this framework are therefore suitable for forwarding, processing and rendering within a heterogeneous mob...

  19. Immunogenetics and genetic susceptibility in the pathogenesis of autoimmune hepatitis

    Directory of Open Access Journals (Sweden)

    Das Anup K

    2014-11-01

    Full Text Available vAutoimmune hepatitis is a progressive liver disease. Its pathogenesis is unclear, but needs a ‘trigger’ to initiate the disease in a genetically susceptible person. The susceptibility is partly related to MHCII class genes, and more so with human leukocyte antigen (HLA. Several mechanisms have been proposed which, however, cannot fully explain the immunologic findings in autoimmune hepatitis. The susceptibility to any autoimmune disease is determined by several factors where genetic and immunological alterations, along with, environmental factor are active. MHCII antigens as a marker for AIH, or a predictor of treatment response and prognosis has been investigated. Since MHCII antigens show significant ethnic heterogeneity, mutations in MHCII may merely act as only precursors of the surface markers of immune cells, which can be of significance, because the changes in HLA and MHC are missing in certain populations. One such marker is the CTLA-4 (CD152 gene mutation, reported in the phenotypes representing susceptibility to AIH. Other candidate genes of cytokines, TNF, TGF-beta1 etc, have also been investigated but with unvalidated results. Paediatric AIH show differences in genetic susceptibility. Genetic susceptibility or resistance to AIH may be associated with polypeptides in DRB1 with certain amino-acid sequences. Understanding which genes are implicated in genesis and/or disease progression will obviously help to identify key pathways in AIH and provide better insights into its pathogenesis. But studies to identify responsible genes are complex because of the complex trait of AIH.

  20. Signed Total Roman Edge Domination In Graphs

    Directory of Open Access Journals (Sweden)

    Asgharsharghi Leila

    2017-11-01

    Full Text Available Let G = (V,E be a simple graph with vertex set V and edge set E. A signed total Roman edge dominating function of G is a function f : Ʃ → {−1, 1, 2} satisfying the conditions that (i Ʃe′∈N(e f(e′ ≥ 1 for each e ∈ E, where N(e is the open neighborhood of e, and (ii every edge e for which f(e = −1 is adjacent to at least one edge e′ for which f(e′ = 2. The weight of a signed total Roman edge dominating function f is !(f = Ʃe∈E f(e. The signed total Roman edge domination number y′stR(G of G is the minimum weight of a signed total Roman edge dominating function of G. In this paper, we first prove that for every tree T of order n ≥ 4, y′stR(T ≥ 17−2n/5 and we characterize all extreme trees, and then we present some sharp bounds for the signed total Roman edge domination number. We also determine this parameter for some classes of graphs.

  1. The psychotherapist and the sign language interpreter.

    Science.gov (United States)

    de Bruin, Ed; Brugmans, Petra

    2006-01-01

    Specialized psychotherapy for deaf people in the Dutch and Western European mental health systems is still a rather young specialism. A key policy principle in Dutch mental health care for the deaf is that they should receive treatment in the language most accessible to them, which is usually Dutch Sign Language (Nederlandse Gebarentaal or NGT). Although psychotherapists for the deaf are trained to use sign language, situations will always arise in which a sign language interpreter is needed. Most psychotherapists have the opinion that working with a sign language interpreter in therapy sessions can be a valuable alternative option but also see it as a second-best solution because of its impact on the therapeutic process. This paper describes our years of collaborationship as a therapist and a sign language interpreter. If this collaborationship is optimal, it can generate a certain "therapeutic power" in the therapy sessions. Achieving this depends largely on the interplay between the therapist and the interpreter, which in our case is the result of literature research and our experiences during the last 17 years. We analyze this special collaborative relationship, which has several dimensions and recurrent themes like, the role conception of the interpreter, situational interpreting, organizing the interpretation setting, or managing therapeutic phenomena during therapy sessions.

  2. Topological susceptibility from the overlap

    DEFF Research Database (Denmark)

    Del Debbio, Luigi; Pica, Claudio

    2003-01-01

    The chiral symmetry at finite lattice spacing of Ginsparg-Wilson fermionic actions constrains the renormalization of the lattice operators; in particular, the topological susceptibility does not require any renormalization, when using a fermionic estimator to define the topological charge. Theref...

  3. Multiple phase transitions of the susceptible-infected-susceptible epidemic model on complex networks

    CERN Document Server

    Mata, Angélica S

    2014-01-01

    We show that the susceptible-infected-susceptible (SIS) epidemic dynamics running on the top of networks with a power law degree distribution can exhibit multiple phase transitions. Three main transitions involving different mechanisms responsible by sustaining the epidemics are identified: A short-term epidemics concentrated around the most connected vertex; a long-term (asymptotically stable) localized epidemics with a vanishing threshold; and an endemic phase occurring at a finite threshold. The different transitions are suited through different mean-field approaches. We finally show that the multiple transitions are due to the activations of different domains of the network that are observed in rapid (singular) variations of both stationary density of infected vertices and the participation ratio against the infection rate.

  4. Influence of Teflon{sup Registered-Sign} agglutinator on TLD spodumene pellets

    Energy Technology Data Exchange (ETDEWEB)

    D' Amorim, R.A.P.O., E-mail: raquelalinep@hotmail.com [Departamento de Fisica, Universidade Federal de Sergipe, P. O. Box 353, 49100-000 Sao Cristovao, SE (Brazil); Teixeira, M.I., E-mail: miteixeira@ipen.br [Instituto de Pesquisas Energeticas e Nucleares-IPEN-CNEN/SP, Av. Prof Lineu Prestes, 2242, 05508-000 Sao Paulo (Brazil); Souza, S.O., E-mail: susanasouzalalic@gmail.com [Departamento de Fisica, Universidade Federal de Sergipe, P. O. Box 353, 49100-000 Sao Cristovao, SE (Brazil); Sasaki, J.M., E-mail: sasaki@fisica.ufc.br [Departamento de Fisica, Universidade Federal do Ceara, CE (Brazil); Caldas, L.V.E., E-mail: lcaldas@ipen.br [Instituto de Pesquisas Energeticas e Nucleares-IPEN-CNEN/SP, Av. Prof Lineu Prestes, 2242, 05508-000 Sao Paulo (Brazil)

    2012-02-15

    The possibility of using different materials for thermoluminescent dosimetry agglutinating their powder with Teflon{sup Registered-Sign} (a polymer) has been studied in recent years. In this paper the thermoluminescent properties of spodumene-Teflon{sup Registered-Sign} composites were studied exposing them to different doses of a {sup 60}Co radiation source, in comparison to the thermoluminescent properties of crystalline powder and of Teflon. The thermoluminescent emission curve of pure Teflon{sup Registered-Sign} pellets showed two peaks at 200 and 250 Degree-Sign C at doses above 1 kGy, which may influence the dosimetry of high-doses that uses crystals agglutinated with this polymer. Preliminary results show that the Teflon{sup Registered-Sign} causes an increased sensitivity in the TL signal of the pellet compared to the crystalline powder without the polymer, and that even the pure Teflon{sup Registered-Sign} pellet is a material that can be exploited for high-doses dosimetry. - Highlights: Black-Right-Pointing-Pointer Teflon{sup Registered-Sign} pellet is a material that can be exploited for high-doses dosimetry. Black-Right-Pointing-Pointer Pure Teflon{sup Registered-Sign} pellets showed two TL peaks at doses above 1 kGy. Black-Right-Pointing-Pointer High-doses dosimetry with pellets agglutinated with Teflon{sup Registered-Sign} may be influenced by it. Black-Right-Pointing-Pointer Teflon{sup Registered-Sign} may cause an increased sensitivity in the TL signal of the pellet.

  5. The signs B and B-bent in Israeli sign language according to the theory of Phonology as Human Behavior.

    Science.gov (United States)

    Fuks, Orit; Tobin, Yishai

    2008-01-01

    The purpose of the present research is to examine which of the two factors: (1) the iconic-semiotic factor; or (2) the human-phonetic factor is more relevant in explaining the appearance and distribution of the hand shape B-bent in Israeli Sign Language (ISL). The B-bent shape has been the subject of much attention in sign language research revolving around the question of its status as a phoneme. The arguments supporting the phonemic status of the B-bent hand shape have been primarily based on the semiotic opposition between the hand shape B and the hand shape B-bent. It has been claimed that in Italian Sign Language the hand shape B is perceptually distinct from the hand shape B-bent, i.e. in opposition to the general, neutral, unmarked meaning of the hand shape B, the iconic hand shape B-bent has a more narrow, specific and marked meaning: DELIMIT. The B-bent hand shape appears in spatial-temporal signs such as "a little before, ahead, postpone or behind". In these signs the iconic structure of the hand shape B-bent is utilized to mark borders in space and time. The arguments opposing the perceptual/phonemic distinction between these hand shapes is based on the human-phonetic factor, i.e. the need to reduce the effort on the part of the wrist joints in specific phonetic environments. We performed a quantitative and qualitative content analysis of the distribution of the basic units of 560 lexical signs taken from a stratified random sample from the ISL dictionary. The results were analyzed in the framework of the sign-oriented linguistic theory of the Columbia School including the theory of Phonology as Human Behavior. Our data revealed that the B-bent hand shape--as all the "building blocks" of the ISL--is a morpho-phonemic unit. We found that there is not only a phonemic distinction between hand shape B and hand shape B-bent in ISL (based on minimal pairs), but there is also a perceptual distinction between them. The qualitative analysis shows that the

  6. The Sound of Silence in Nohya: A Preliminary Account of Sign Language Use by the Deaf in a Maya Community in Yucatan, Mexico.

    Science.gov (United States)

    Shuman, Malcom L.

    1980-01-01

    A description of the sign language used in a Mexican village shows its parallels with other sign languages, its similarity to the folk gestural system of Mexico and its distinguishing aspects. Examples illustrate its syntax, grammar and lexicon. (PMJ)

  7. First signs of elderly gait for women.

    Science.gov (United States)

    Kaczmarczyk, Katarzyna; Wiszomirska, Ida; Błażkiewicz, Michalina; Wychowański, Michał; Wit, Andrzej

    2017-06-27

    The aims of this study have been twofold: to attempt to reduce the number of spatiotemporal parameters used for describing gait through the factor analysis and component analysis; and to explore the critical age of decline for other gait parameters for healthy women. A total of 106 women (aged ≥ 40 years old (N = 76) and ≤ 31 years old (N = 30)) were evaluated using a pressure-sensitive mat (Zebris Medical System, Tübingen, Germany) for collecting spatiotemporal gait parameters. The factor analysis identified 2 factors - labelled Time and Rhythm - that accounted for 72% of the variation in significant free-gait parameters; the principal component analysis identified 4 of these parameters that permit full clinical evaluation of gait quality. No difference was found between the groups in terms of the values of parameters reflecting the temporal nature of gait (Rhythm), namely step time, stride time and cadence, whereas significant differences were found for total double support phase (p gait, we selected 3 parameters: total double support, stride time and velocity. We concluded that the women taking part in the experiment manifested significant signs of senile gait after the age of 60 years old, with the first symptoms thereof already manifesting themselves after 50 years of age. We show that among 26 spatiotemporal parameters that may be used for characterizing gait, at least a half of them may be omitted in the assessment of gait correctness; a finding that may be useful in clinical practice. The finding that the onset of senile gait occurs in the case of women after the age of 60 years old, in turn, may be useful in evaluating the ability for performing types of physical work that mainly require ambulation. Med Pr 2017;68(4):441-448.

  8. Signs of learning in kinaesthetic science activities

    DEFF Research Database (Denmark)

    Bruun, Jesper; Johannsen, Bjørn Friis

    The study addresses how students use communicative signs (e.g., speech and gesture) to shape and develop cognitive schemas during a bodily exploration of force and motion in a physics teaching-learning activity. We see ‘the experiential gestalt of causation’ as a cognitive element that may be used...... to couple an embodied experience of physics with the language of physics through dialogue. We propose that kinaesthetic learning is a way of integrating a bodily experience into a formal system of signs, in this case, force and motion in physics, but ask: to a teacher or researcher, what signs exist...... that students use bodily explorations to construct meaning and understanding from kinaesthetic learning that is relevant to school physics? To answer the question, we employ a semiotics perspective to analyse data from a 1-hour lesson for 8-9th graders which introduced students to kinaesthetic activities, where...

  9. The "double panda" sign in Leigh disease.

    Science.gov (United States)

    Sonam, Kothari; Bindu, P S; Gayathri, Narayanappa; Khan, Nahid Akhtar; Govindaraju, C; Arvinda, Hanumanthapura R; Nagappa, Madhu; Sinha, Sanjib; Thangaraj, K; Taly, Arun B

    2014-07-01

    Although the "face of the giant panda" sign on magnetic resonance imaging (MRI) is traditionally considered to be characteristic of Wilson disease, it has also been reported in other metabolic disorders. This study describes the characteristic "giant panda" sign on MRI in a child with Leigh disease. The diagnosis was based on the history of neurological regression; examination findings of oculomotor abnormalities, hypotonia, and dystonia; raised serum lactate levels; and characteristic brain stem and basal ganglia signal changes on MRI. The midbrain and pontine tegmental signal changes were consistent with the "face of the giant panda and her cub" sign. In addition to Wilson disease, metabolic disorders such as Leigh disease should also be considered in the differential diagnosis of this rare imaging finding. © The Author(s) 2013.

  10. Signs in neuroradiology: A pictorial review

    Energy Technology Data Exchange (ETDEWEB)

    Kizilca, Ozgur; Oztek, Alp; Kesimal, Ugur; Senol, Utku [Dept. of Radiology, Akdeniz University Faculty of Medicine, Antalya (Turkmenistan)

    2017-11-15

    One of the major problems radiologists face in everyday practice is to decide the correct diagnosis, or at least narrow down the list of possibilities. In this context, indicative evidences (signs) are useful to recognize pathologies, and also to narrow the list of differential diagnoses. Despite classically being described for a single disease, or a closely related family of disorders, most indications are not restricted exclusively to their traditional definition. Therefore, using signs for prognosis requires knowledge of the mechanism of their appearance, and which pathologies they are observed in. In this study, we demonstrate some of the more common and useful neuroradiologic signs with relevant images, and discuss their use in differential diagnosis.

  11. A Sign Language Screen Reader for Deaf

    Science.gov (United States)

    El Ghoul, Oussama; Jemni, Mohamed

    Screen reader technology has appeared first to allow blind and people with reading difficulties to use computer and to access to the digital information. Until now, this technology is exploited mainly to help blind community. During our work with deaf people, we noticed that a screen reader can facilitate the manipulation of computers and the reading of textual information. In this paper, we propose a novel screen reader dedicated to deaf. The output of the reader is a visual translation of the text to sign language. The screen reader is composed by two essential modules: the first one is designed to capture the activities of users (mouse and keyboard events). For this purpose, we adopted Microsoft MSAA application programming interfaces. The second module, which is in classical screen readers a text to speech engine (TTS), is replaced by a novel text to sign (TTSign) engine. This module converts text into sign language animation based on avatar technology.

  12. English Shop Signs and Brand Names

    Directory of Open Access Journals (Sweden)

    Parvaneh Khosravizadeh

    2016-07-01

    Full Text Available The present study tries to investigate the people’s attitude to the use of English words in TV commercials, brand-naming and shop signs in Iran and specifically in Tehran where due to the fact that it is the capital, more English might be used for the sake of foreigners. The widespread use of English shop signs and English brand names for recently produced goodsdrove the researchers to investigate peoples’ attitude as consumers from two aspects of age and education. To reach the research goal, a questionnaire was devised and distributed to 100 people at random selection probing their attitudes while considering two factors of age and education. The result of the research will mostly benefit sociolinguists and business marketers.Keywords: age, education, advertising, brand-naming, shop signs, globalization

  13. Relations between language and cognition in native-signing children with autism spectrum disorder.

    Science.gov (United States)

    Shield, Aaron; Pyers, Jennie; Martin, Amber; Tager-Flusberg, Helen

    2016-12-01

    Two populations have been found to exhibit delays in theory of mind (ToM): deaf children of hearing parents and children with autism spectrum disorder (ASD). Deaf children exposed to sign from birth by their deaf parents, however, show no such delay, suggesting that early language exposure is key to ToM development. Sign languages also present frequent opportunities with visual perspective-taking (VPT), leading to the question of whether sign exposure could benefit children with ASD. We present the first study of children with ASD exposed to sign from birth by their deaf parents. Seventeen native-signing children with a confirmed ASD diagnosis and a chronological- and mental age-matched control group of 18 typically developing (TD) native-signing deaf children were tested on American Sign Language (ASL) comprehension, two minimally verbal social cognition tasks (ToM and VPT), and one spatial cognition task (mental rotation). The TD children outperformed the children with ASD on ASL comprehension (p Language strongly correlated with ToM (p Native exposure to sign is thus insufficient to overcome the language and social impairments implicated in ASD. Contrary to the hypothesis that sign could provide a scaffold for ToM skills, we find that signing children with ASD are unable to access language so as to gain any potential benefit sign might confer. Our results support a strong link between the development of social cognition and language, regardless of modality, for TD and ASD children. Autism Res 2016, 9: 1304-1315. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

  14. Transition to Subspecialty Sign-Out at an Academic Institution and Its Advantages

    Directory of Open Access Journals (Sweden)

    Joanna L. Conant MD

    2017-07-01

    Full Text Available Many pathology departments are introducing subspecialty sign-out in surgical pathology. In 2014, the University of Vermont Medical Center transitioned from general sign-out to partial subspecialty sign-out to include gastrointestinal and breast/cervix subspecialty benches; other specimens remained on general benches. Our experiences with the transition are described, including attending pathologist, trainee, support staff, and clinician satisfaction. A survey was e-mailed to all University of Vermont Medical Center anatomic pathology attendings, pathology trainees, pathologist assistants and grossing technicians, and clinicians who send surgical pathology specimens, immediately before and 1 year after transitioning to partial subspecialty sign-out. Quality assurance metrics were obtained for the 18 months prior to and following the transition. Gastrointestinal and breast/cervix attendings were more satisfied with partial subspecialty sign-out compared to those on the general benches. Overall, trainees were more satisfied with general sign-out because of the rotation schedule but preferred partial subspecialty sign-out due to improved teaching and more focused learning while on subspecialty benches. Clinicians remained very satisfied with our department and our reports; no differences were observed. Turnaround time was unchanged. After switching to partial subspecialty sign-out, there were significantly fewer discrepancies following multidisciplinary conference review for gastrointestinal and breast/cervix cases but remained the same for general cases. Fewer formal internal consults were performed after transitioning to partial subspecialty sign-out across all areas, but more notable for gastrointestinal and breast/cervix cases. Our data show improved quality assurance metrics and trainee education in a subspecialty sign-out setting compared to general sign-out setting.

  15. Sign Recognition Processes in American Sign Language: The Effect of Context.

    Science.gov (United States)

    Clark, Lorene E.; Grosjean, Francois

    1982-01-01

    Individual signs were presented to deaf fluent signers both in context and without context. Within context, signs were isolated sooner, perfect confidence in the response was reached sooner, and a narrowing-in process was found that was both semantic and phonological. Current spoken-word-recognition models could be modified to reflect…

  16. Signs of Resistance: Peer Learning of Sign Languages within "Oral" Schools for the Deaf

    Science.gov (United States)

    Anglin-Jaffe, Hannah

    2013-01-01

    This article explores the role of the Deaf child as peer educator. In schools where sign languages were banned, Deaf children became the educators of their Deaf peers in a number of contexts worldwide. This paper analyses how this peer education of sign language worked in context by drawing on two examples from boarding schools for the deaf in…

  17. The relationship between sign production and sign comprehension: What handedness reveals.

    Science.gov (United States)

    Watkins, Freya; Thompson, Robin L

    2017-07-01

    Unlike the phonological loop in spoken language monitoring, sign language users' own production provides mostly proprioceptive feedback and only minimal visual feedback. Here we investigate whether sign production influences sign comprehension by exploiting hand dominance in a picture-sign matching task performed by left-handed signers and right-handed signers. Should all signers perform better to right-handed input, this would suggest that a frequency effect in sign perception drives comprehension. However, if signers perform better to congruent-handed input, this would implicate the production system's role in comprehension. We found evidence for both hypotheses, with variation dependent on sign type. All signers performed faster to right-handers for phonologically simple, one-handed signs. However, left-handed signers preferred congruent-handed input for phonologically complex, two-handed asymmetrical signs. These results are in line with a weak version of the motor theory of speech perception, where the motor system is only engaged when comprehending complex input. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  18. Spoken Language Activation Alters Subsequent Sign Language Activation in L2 Learners of American Sign Language.

    Science.gov (United States)

    Williams, Joshua T; Newman, Sharlene D

    2017-02-01

    A large body of literature has characterized unimodal monolingual and bilingual lexicons and how neighborhood density affects lexical access; however there have been relatively fewer studies that generalize these findings to bimodal (M2) second language (L2) learners of sign languages. The goal of the current study was to investigate parallel language activation in M2L2 learners of sign language and to characterize the influence of spoken language and sign language neighborhood density on the activation of ASL signs. A priming paradigm was used in which the neighbors of the sign target were activated with a spoken English word and compared the activation of the targets in sparse and dense neighborhoods. Neighborhood density effects in auditory primed lexical decision task were then compared to previous reports of native deaf signers who were only processing sign language. Results indicated reversed neighborhood density effects in M2L2 learners relative to those in deaf signers such that there were inhibitory effects of handshape density and facilitatory effects of location density. Additionally, increased inhibition for signs in dense handshape neighborhoods was greater for high proficiency L2 learners. These findings support recent models of the hearing bimodal bilingual lexicon, which posit lateral links between spoken language and sign language lexical representations.

  19. Adaptation of a Vocabulary Test from British Sign Language to American Sign Language

    Science.gov (United States)

    Mann, Wolfgang; Roy, Penny; Morgan, Gary

    2016-01-01

    This study describes the adaptation process of a vocabulary knowledge test for British Sign Language (BSL) into American Sign Language (ASL) and presents results from the first round of pilot testing with 20 deaf native ASL signers. The web-based test assesses the strength of deaf children's vocabulary knowledge by means of different mappings of…

  20. The Use of Sign Language Pronouns by Native-Signing Children with Autism

    Science.gov (United States)

    Shield, Aaron; Meier, Richard P.; Tager-Flusberg, Helen

    2015-01-01

    We report the first study on pronoun use by an under-studied research population, children with autism spectrum disorder (ASD) exposed to American Sign Language from birth by their deaf parents. Personal pronouns cause difficulties for hearing children with ASD, who sometimes reverse or avoid them. Unlike speech pronouns, sign pronouns are…