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Sample records for susceptibility logging system

  1. Improving NMR Diffusion Logs by Accounting for High Magnetic Susceptibility in Sediments

    Science.gov (United States)

    Fay, E. L.; Knight, R. J.

    2013-12-01

    Nuclear magnetic resonance (NMR) well-logging can be used to measure the apparent diffusion coefficient of fluids in the soil or rock around a well. NMR diffusion logs have several potential applications in the field of hydrogeophysics, such as improving estimates of permeability and characterizing LNAPL contamination. Near-surface environments, however, offer an added challenge to measuring diffusion with NMR due to the high variability in the magnetic mineral content of soils. In this work, we were able to improve the accuracy of diffusion measurements from an NMR log by accounting for the magnetic susceptibility of the sediments. NMR diffusion measurements have been used extensively both in laboratory and logging applications to measure the relative saturation of water, gas, and oil in reservoir rocks, due to the contrasting diffusion coefficients of these fluids. Laboratory diffusion measurements have also been used to study restricted diffusion in pore systems, which yields information on the pore size and the connectivity of the pore space, both critical to predicting the permeability of a material. NMR diffusion measurements rely on the application of an external magnetic field gradient across the measured volume. This magnetic field gradient is used to measure the displacement of fluid molecules during a specified diffusion time interval. The magnitude of the effective field gradient, i.e. the gradient experienced in the measured volume, must be known in order to calculate of the diffusion coefficient of the fluid from the NMR signal. Common practice in NMR logging is to assume that internal gradients are negligible and that the effective gradient is equal to the externally applied gradient, which is typically well characterized. In materials with low magnetic susceptibility, this is a valid assumption. Complications arise in materials with high magnetic susceptibility, because magnetic field gradients will be present within these materials before the

  2. LHCb Online Log Analysis and Maintenance System

    CERN Document Server

    Garnier, J-C; Neufeld, N; Nikolaidis, F

    2011-01-01

    History has shown, many times computer logs are the only information an administrator may have for an incident, which could be caused either by a malfunction or an attack. Due to the huge amount of logs that are produced from large-scale IT infrastructures, such as LHCb Online, critical information may be overlooked or simply be drowned in a sea of other messages. This clearly demonstrates the need for an automatic system for long-term maintenance and real time analysis of the logs. We have constructed a low cost, fault tolerant centralized logging system which is able to do in-depth analysis and cross-correlation of every log. This system is capable of handling O(10000) different log sources and numerous formats, while trying to keep the overhead as low as possible. It provides log gathering and management, Offline analysis and online analysis. We call Offline analysis the procedure of analyzing old logs for critical information, while Online analysis refer to the procedure of early alerting and reacting. ...

  3. Assessment of procurement systems for unutilized logging residues ...

    African Journals Online (AJOL)

    Assessment of procurement systems for unutilized logging residues for Brutian pine forest of Turkey. ... Three system scenarios were modeled for the procurement of logging residues left in the forest after clear-cutting operation with cutto- length harvesting method. The first and second systems were the roadside chipping ...

  4. DIY Soundcard Based Temperature Logging System. Part II: Applications

    Science.gov (United States)

    Nunn, John

    2016-01-01

    This paper demonstrates some simple applications of how temperature logging systems may be used to monitor simple heat experiments, and how the data obtained can be analysed to get some additional insight into the physical processes. [For "DIY Soundcard Based Temperature Logging System. Part I: Design," see EJ1114124.

  5. Assessment of procurement systems for unutilized logging residues ...

    African Journals Online (AJOL)

    user

    2011-03-28

    Mar 28, 2011 ... This study examined the possibilities and feasibility of increasing the procurement of logging residues intended for bioenergy from forests in Turkey. The state of the art of potential procurement technology of logging residues was investigated to examine the purposes of configuring a supply system to.

  6. Plutonium waste crib logging using the prompt fission neutron uranium logging system

    Energy Technology Data Exchange (ETDEWEB)

    Barnard, R.W.; Stephenson, W.A.

    1980-05-01

    Sandia Laboratories' Uranium Logging Project has demonstrated their prompt fission neutron (PFN) logging system at the Hanford, WA, site for Rockwell-Hanford Operations (RHO). The dates of the demonstration were July 31 through August 2, 1979. The purpose was to show RHO the capabilities of the system for measuring plutonium concentration. An underground effluent disposal crib associated with their processing facilities was used as the test site. The performance criterion was to be able to detect a 10 nCi/g concentration of plutonium. Six test wells penetrating the crib were logged, as were three other wells. The PFN tool was able to maintain a good signal-to-noise ratio even under the most extreme conditions of high count rate and high background. The wells at the center of the crib indicated very high concentrations of plutonium, while those at the periphery indicated much less. Concentrations estimated to be lower than 10 nCi/g were detected. Comparisons with core data were not made. The technique used to obtain physical samples for analysis did not follow uranium-exploration coring practice so comparisons were not possible. The data interpretation model used was originally developed for uranium and was modified to calculate plutonium concentration. Results indicated that the operation of a PFN logging system by RHO personnel would provide a suitable technique for monitoring transuranic waste storage sites.

  7. Cross-system log file analysis for hypothesis testing

    NARCIS (Netherlands)

    Glahn, Christian

    2008-01-01

    Glahn, C. (2008). Cross-system log file analysis for hypothesis testing. Presented at Empowering Learners for Lifelong Competence Development: pedagogical, organisational and technological issues. 4th TENCompetence Open Workshop. April, 10, 2008, Madrid, Spain.

  8. Freedom of Information Act Request Log System -

    Data.gov (United States)

    Department of Transportation — This system manages FHWA FOIA requests and is used to better meet the extensive annual reporting requirements imposed by statute (5 USC § 552). The FOIA Management...

  9. Automatic Data Logging and Quality Analysis System for Mobile Devices

    Directory of Open Access Journals (Sweden)

    Yong-Yi Fanjiang

    2017-01-01

    Full Text Available The testing phase of mobile device products includes two important test projects that must be completed before shipment: the field trial and the beta user trial. During the field trial, the product is certified based on its integration and stability with the local operator’s system, and, during the beta user trial, the product is certified by multiple users regarding its daily use, where the goal is to detect and solve early problems. In the traditional approach used to issue returns, testers must log into a web site, fill out a problem form, and then go through a browser or FTP to upload logs; however, this is inconvenient, and problems are reported slowly. Therefore, we propose an “automatic logging analysis system” (ALAS to construct a convenient test environment and, using a record analysis (log parser program, automate the parsing of log files and have questions automatically sent to the database by the system. Finally, the mean time between failures (MTBF is used to establish measurement indicators for the beta user trial.

  10. An integrated 3D log processing optimization system for small sawmills in central Appalachia

    Science.gov (United States)

    Wenshu Lin; Jingxin. Wang

    2013-01-01

    An integrated 3D log processing optimization system was developed to perform 3D log generation, opening face determination, headrig log sawing simulation, fl itch edging and trimming simulation, cant resawing, and lumber grading. A circular cross-section model, together with 3D modeling techniques, was used to reconstruct 3D virtual logs. Internal log defects (knots)...

  11. Operation event logging system of the Swiss Light Source

    Science.gov (United States)

    Lüdeke, Andreas

    2009-02-01

    Modern 3rd generation synchrotron light sources aim for 100% availability. No single beam interruption is acceptable and every beam disturbance should be investigated: what caused the interruption? Can it be avoided in the future? If it cannot be avoided, how can the recovery be accelerated? An automated event recording system has been implemented at the Swiss Light Source (SLS) in order to simplify beam distortion investigations with respect to a well-defined metrics. The system identifies beam disturbances and records automatically the type and duration of the event. Relevant information of the event, like control system archive data or shift summaries, is linked to the event and presented in Web pages. Tools for the automated evaluation of alarm logs are provided that generate summaries of a beam distortion. On the basis of this information each event will be assigned to a failure cause. The means to filter the events are provided. We will describe the concept and the implementation of the system at the SLS and our experiences with it. Finally, the SLS operation event logging system will be compared with failure analysis at other light sources.

  12. Design and Evaluation of Log-To-Dimension Manufacturing Systems Using System Simulation

    Science.gov (United States)

    Wenjie Lin; D. Earl Kline; Philip A. Araman; Janice K. Wiedenbeck

    1995-01-01

    In a recent study of alternative dimension manufacturing systems that produce green hardwood dimension directly fromlogs, it was observed that for Grade 2 and 3 red oak logs, up to 78 and 76 percent of the log scale volume could be converted into clear dimension parts. The potential high yields suggest that this processing system can be a promising technique for...

  13. Technoeconomic analysis of conventional logging systems operating from stump to landing

    Science.gov (United States)

    Raymond L. Sarles; William G. Luppold; William G. Luppold

    1986-01-01

    Analyzes technical and economic factors for six conventional logging systems suitable for operation in eastern forests. Discusses financial risks and business implications for loggers investing in high-production, state-of-the-art logging systems. Provides logging contractors with information useful as a preliminary guide for selection of equipment and systems....

  14. System em um operador logístico (3PL

    Directory of Open Access Journals (Sweden)

    Douglas Ribeiro Novaes

    2016-11-01

    Full Text Available With the constant technological advancement, the companies started to invest in new systems to support competitiveness in the market in which they operate. This article aims to describe the process of deployment of the technology Warehouse Management System. The tool known as WMS is a system that facilitates the handling operations and storage materials through defined parameters, but the deployment of this system need to go through steps that impact positively and negatively the company's various sectors. This study was developed because of the existence of questions related to the development of the implementation of project presenting departments and professionals involved in the process and due to the need to clarify doubts about the usefulness of system. This document was based on specific literature and complemented by a case study on the company Julio Simoes Logística S / A through an interview with the organization's representative. In order to logistics operator perform their daily activities as receipt, storage and dispatch efficiently it is necessary  a technology that provides accurate and reliable data,  and that make available information that allows the company, to improve its operations.

  15. When Workflow Management Systems and Logging Systems Meet: Analyzing Large-Scale Execution Traces

    Energy Technology Data Exchange (ETDEWEB)

    Gunter, Daniel

    2008-07-31

    This poster shows the benefits of integrating a workflow management system with logging and log mining capabilities. By combing two existing, mature technologies: Pegasus-WMS and Netlogger, we are able to efficiently process execution logs of earthquake science workflows consisting of hundreds of thousands to one million tasks. In particular we show results of processing logs of CyberShake, a workflow application running on the TeraGrid. Client-side tools allow scientists to quickly gather statistics about a workflow run and find out which tasks executed, where they were executed, what was their runtime, etc. These statistics can be used to understand the performance characteristics of a workflow and help tune the execution parameters of the workflow management system. This poster shows the scalability of the system presenting results of uploading task execution records into the system and by showing results of querying the system for overall workflow performance information.

  16. Development of a 3D log sawing optimization system for small sawmills in central Appalachia, US

    Science.gov (United States)

    Wenshu Lin; Jingxin Wang; Edward. Thomas

    2011-01-01

    A 3D log sawing optimization system was developed to perform log generation, opening face determination, sawing simulation, and lumber grading using 3D modeling techniques. Heuristic and dynamic programming algorithms were used to determine opening face and grade sawing optimization. Positions and shapes of internal log defects were predicted using a model developed by...

  17. DIY Soundcard Based Temperature Logging System. Part I: Design

    Science.gov (United States)

    Nunn, John

    2016-01-01

    This paper aims to enable schools to make their own low-cost temperature logging instrument and to learn something about its calibration in the process. This paper describes how a thermistor can be integrated into a simple potential divider circuit which is powered with the sound output of a computer and monitored by the microphone input. The…

  18. A low cost data logging system with satellite transmission capabilities

    Digital Repository Service at National Institute of Oceanography (India)

    Desa, E.S.; DeSa, E.J.; Desai, R.G.P.

    The concept of updating a shore based data bank by regular satellite transmissions of data collected at sea has important uses in programmes on the exploration and survey of sea bed mineral sites. In this context, the need arose to log data from a...

  19. Design and Implementation of a Robotic Surgery Training Experience Logging System.

    Science.gov (United States)

    Baldea, Kristin G; Thorwarth, Ryan; Bajic, Petar; Quek, Marcus L; Gupta, Gopal N

    Residents currently log robotic cases in the ACGME system as a "surgeon" if they performed any critical step of the procedure on the surgeon console. There is no standardization as to which steps or how much of the procedure should be performed by the resident. It was our objective to establish a tool for logging the true operative experience in robotic surgery to aid in assessing surgical competency as well as curriculum development. We propose a tool to log surgical skill progression, experience, and feedback for robotic cases. A web-based robotic experience logging system (RoboLog) was developed with procedures deconstructed to their major steps. Trainees may request the supervising attending review their performance. RoboLog provides automated summary reports to both residents and attendings. RoboLog was successfully developed and piloted with a total of 310 cases logged over 1 year. A reporting structure was developed where residents could view statistics on several data points such as step-specific involvement and feedback from attending staff. Detailed data on resident experience were obtained. For instance, 82% of the 151 robotic prostatectomies were logged as "surgeon", yet urethral transection had <35% resident involvement. Our current system for logging robotic experience is lacking given the fact that resident involvement on the surgical console is variable. Widespread usage of a logging system with more insight into step-specific involvement is needed. RoboLog fills this need and can be used to track robotic training progress and aid in development of a standardized curriculum. Copyright © 2017. Published by Elsevier Inc.

  20. System Combination with Log Linear Models (Author’s Manuscript)

    Science.gov (United States)

    2016-05-19

    separately possibly with different features (e.g. MFCC or fil- ter bank) and training criteria (e.g. ML or MPE), but they share the same hidden Markov model ...to use automatic approaches based on phonetic decision trees [18]. In the definition of the joint feature (4), the language feature φlm(·) for the...with 13d PLP and 40d log-Mel filter bank (FBK) coefficients. A triphone state set with 3063 tied-states produced by the decision tree tying approach

  1. Relationship between Self-Report and Log Data Estimates of Information System Usage.

    Science.gov (United States)

    Deane, Frank P.; Podd, John; Henderson, Ron D.

    1998-01-01

    Discussion of self-report estimates of frequency and duration of computer use versus computer log data focuses on a study that compared self-report estimates and six months of electronic log data for health care workers using a new Community Services Information System. Correlations between the two types of data are reported. (Author/LRW)

  2. A simple low cost speed log interface for oceanographic data acquisition system

    Digital Repository Service at National Institute of Oceanography (India)

    Khedekar, V.D.; Phadte, G.M.

    A speed log interface is designed with parallel Binary Coded Decimal output. This design was mainly required for the oceanographic data acquisition system as an interface between the speed log and the computer. However, this can also be used as a...

  3. Multi-Sensor Core Logger (MSCL) P-wave velocity, gamma-ray density, and magnetic susceptibility whole-core logs of sediment cores collected in 2009 offshore from Palos Verdes, California

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This part of the data release includes Multi-Sensor Core Logger (MSCL) P-wave velocity, gamma-ray density, and magnetic susceptibility whole-core logs of sediment...

  4. MODELING OF LOG PROCESSING PRODUCTIVITY OF EUCALYPT PLANTED IN AGROFOREST SYSTEMS1

    Directory of Open Access Journals (Sweden)

    Álvaro Nogueira de Souza

    2007-06-01

    Full Text Available This work fitted regression models in order to estimate the efficiency of wood processing in sawmills using trees from agro-forest systems. Specifically, it intended to determine the yield of processed boards volume, to adjust models for measuring the processing efficiency and the time needed for processing wood as a function of dendrometric variables, considering two different products. The database was composed of information derived from 150 logs of eucalypt clones encompassing 5 diameter classes. The real volume of each log was derived through detailed log scaling according to Smalian’s method. After log processing, the boards were measured to determine the volume of sawn wood. The time needed for processing and the log dimensions were used to fit efficiency models as a function of time and of dendrometric characteristics. The equations were evaluated based on the coefficient of determination, standard error of estimation and graphic distribution of residues. The equations to estimate the processing efficiency were more influenced by log volume and by the diameter of the largest side. The best equations to estimate the volume of the boards were the ones that included log volume, diameter of the thickest side and log length as independent variables. When considering both products together, the best equations were the ones that included log volume, diameter of the thickest side, diameter of the thinnest side and the type of product as independent variables. The equations used to estimate the time needed to saw the logs were influenced by diameter class, in the case of product 1 and by the volume of the logs in the case of product 2. The equations used to estimate the time needed to process both products together showed similar performance. The time needed was influenced by the dendrometric variables and their combinations.

  5. Water quality management in shrimp aquaculture ponds using remote water quality logging system

    Digital Repository Service at National Institute of Oceanography (India)

    Sreepada, R.A.; Kulkarni, S.; Suryavanshi, U.; Ingole, B.S.; Drensgstig, A.; Braaten, B.

    Currently an institutional co-operation project funded by NORAD is evaluating different environmental management strategies for sustainable aquaculture in India. A brief description of a remote water quality logging system installed in shrimp ponds...

  6. Microcontroller-based data logging instrumentation system for wind ...

    African Journals Online (AJOL)

    In this study, a microcontroller based data logger for measuring wind speed and wind direction has been designed. The designed system uses the Atmel microcontroller family which consists of sensor inputs, a microcontroller and a data storage device. The system was designed and developed to measure the wind speed ...

  7. Computer Vision Systems for Hardwood Logs and Lumber

    Science.gov (United States)

    Philip A. Araman; Tai-Hoon Cho; D. Zhu; R. Conners

    1991-01-01

    Computer vision systems being developed at Virginia Tech University with the support and cooperation from the U.S. Forest Service are presented. Researchers at Michigan State University, West Virginia University, and Mississippi State University are also members of the research team working on various parts of this research. Our goals are to help U.S. hardwood...

  8. Factors that affect fuel consumption in logging systems

    Science.gov (United States)

    Jonathan Kenney; Thomas Gallagher; Matthew Smidt; Dana Mitchell; Timothy. and McDonald

    2014-01-01

    Fuel consumption is an important aspect of the efficiency of timber harvesting. Since loggers are paid based on the weight of wood they produce, it is important to note how many gallons of fuel it takes to produce one ton of wood. An extensive literature review was conducted to evaluate different harvesting systems and the amount of fuel they consumed per unit of wood...

  9. Log Summarization and Anomaly Detection for TroubleshootingDistributed Systems

    Energy Technology Data Exchange (ETDEWEB)

    Gunter, Dan; Tierney, Brian L.; Brown, Aaron; Swany, Martin; Bresnahan, John; Schopf, Jennifer M.

    2007-08-01

    Today's system monitoring tools are capable of detectingsystem failures such as host failures, OS errors, and network partitionsin near-real time. Unfortunately, the same cannot yet be said of theend-to-end distributed softwarestack. Any given action, for example,reliably transferring a directory of files, can involve a wide range ofcomplex and interrelated actions across multiple pieces of software:checking user certificates and permissions, getting details for allfiles, performing third-party transfers, understanding re-try policydecisions, etc. We present an infrastructure for troubleshooting complexmiddleware, a general purpose technique for configurable logsummarization, and an anomaly detection technique that works in near-realtime on running Grid middleware. We present results gathered using thisinfrastructure from instrumented Grid middleware and applications runningon the Emulab testbed. From these results, we analyze the effectivenessof several algorithms at accurately detecting a variety of performanceanomalies.

  10. Application of the electric discharge logging system; Hodenshiki jiban tansa system no tekiyo

    Energy Technology Data Exchange (ETDEWEB)

    Kudo, K.; Yasuda, N. [Tokyo Electric Power Co. Inc., Tokyo (Japan); Kuniyasu, T.; Kanda, K.; Naito, Y.; Tanaka, T.

    1997-10-22

    In the process of developing an electric discharge logging system, the advantage over other methods has become clear of P-wave initial amplitude damping coefficient analysis which is accomplished by measuring P-wave velocity in a hard rockbed and examining oscillation receiver bone sensitivity on the spot. In the hope of furthering the advantage, attention is paid to cracks in the rockbed that are deemed to influence damping, and the measurements by the subject system are compared with BSS measurements recorded at a K underground power station. The results of the analysis of P-wave initial amplitude damping coefficients, determined by the electric discharge logging system operated in a measuring hole provided in the cavity accommodating the station main equipment, disclose that there exists a high-coefficient region deeper in the ground where a part of the rockbed is weak. That is, it is inferred that the wide-range variation in damping coefficient detected at levels deeper than the 20.5m-deep hole dug in the arch enlargement corresponds to looseness in the rockbed. Cracks in the BSS records are grouped by aperture width, inclination angle, and strike. The rate of contribution to P-wave initial amplitude damping of each class of cracks is accepted as what shows the geological conditions surrounding the station for the formulation of schematic diagrams exhibiting cracks along the W-E axis and N-S axis. 4 refs., 15 figs.

  11. Predicting Correctness of Problem Solving from Low-Level Log Data in Intelligent Tutoring Systems

    Science.gov (United States)

    Cetintas, Suleyman; Si, Luo; Xin, Yan Ping; Hord, Casey

    2009-01-01

    This paper proposes a learning based method that can automatically determine how likely a student is to give a correct answer to a problem in an intelligent tutoring system. Only log files that record students' actions with the system are used to train the model, therefore the modeling process doesn't require expert knowledge for identifying…

  12. An Event Logging, Analysis, and Reporting System (ELARS) as a Knowledge Management Technology

    Science.gov (United States)

    2009-04-01

    Systems (SBIRS) program represents a "system of systems," combining the power of geosynchronous orbit (GEO), highly elliptical orbit (HEO), and low...identification and time- stamp information. The monitoring and logging ELARS components can be combined into a powerful to the system; therefore, it...repository. All event-related storage a~d retrieval operations are performed through this component, which represents a central poin ! of access control and

  13. Fracture density estimation from petrophysical log data using the adaptive neuro-fuzzy inference system

    Science.gov (United States)

    Ja'fari, Ahmad; Kadkhodaie-Ilkhchi, Ali; Sharghi, Yoosef; Ghanavati, Kiarash

    2012-02-01

    Fractures as the most common and important geological features have a significant share in reservoir fluid flow. Therefore, fracture detection is one of the important steps in fractured reservoir characterization. Different tools and methods are introduced for fracture detection from which formation image logs are considered as the common and effective tools. Due to the economical considerations, image logs are available for a limited number of wells in a hydrocarbon field. In this paper, we suggest a model to estimate fracture density from the conventional well logs using an adaptive neuro-fuzzy inference system. Image logs from two wells of the Asmari formation in one of the SW Iranian oil fields are used to verify the results of the model. Statistical data analysis indicates good correlation between fracture density and well log data including sonic, deep resistivity, neutron porosity and bulk density. The results of this study show that there is good agreement (correlation coefficient of 98%) between the measured and neuro-fuzzy estimated fracture density.

  14. A Clustering Methodology of Web Log Data for Learning Management Systems

    Science.gov (United States)

    Valsamidis, Stavros; Kontogiannis, Sotirios; Kazanidis, Ioannis; Theodosiou, Theodosios; Karakos, Alexandros

    2012-01-01

    Learning Management Systems (LMS) collect large amounts of data. Data mining techniques can be applied to analyse their web data log files. The instructors may use this data for assessing and measuring their courses. In this respect, we have proposed a methodology for analysing LMS courses and students' activity. This methodology uses a Markov…

  15. On Representing, Purging, and Utilizing Change Logs in Process Management Systems

    NARCIS (Netherlands)

    Rinderle, S.B.; Reichert, M.U.; Jurisch, M.; Kreher, U

    In recent years adaptive process management technolgy has emerged in order to increase the flexibility of business process implementations and to support process changes at different levels. Usually, respective systems log comprehensive information about changes, which can then be used for different

  16. Integration of QR codes into an anesthesia information management system for resident case log management.

    Science.gov (United States)

    Avidan, Alexander; Weissman, Charles; Levin, Phillip D

    2015-04-01

    Quick response (QR) codes containing anesthesia syllabus data were introduced into an anesthesia information management system. The code was generated automatically at the conclusion of each case and available for resident case logging using a smartphone or tablet. The goal of this study was to evaluate the use and usability/user-friendliness of such system. Resident case logging practices were assessed prior to introducing the QR codes. QR code use and satisfactions amongst residents was reassessed at three and six months. Before QR code introduction only 12/23 (52.2%) residents maintained a case log. Most of the remaining residents (9/23, 39.1%) expected to receive a case list from the anesthesia information management system database at the end of their residency. At three months and six months 17/26 (65.4%) and 15/25 (60.0%) residents, respectively, were using the QR codes. Satisfaction was rated as very good or good. QR codes for residents' case logging with smartphones or tablets were successfully introduced in an anesthesia information management system and used by most residents. QR codes can be successfully implemented into medical practice to support data transfer. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  17. Log-Less Metadata Management on Metadata Server for Parallel File Systems

    Directory of Open Access Journals (Sweden)

    Jianwei Liao

    2014-01-01

    Full Text Available This paper presents a novel metadata management mechanism on the metadata server (MDS for parallel and distributed file systems. In this technique, the client file system backs up the sent metadata requests, which have been handled by the metadata server, so that the MDS does not need to log metadata changes to nonvolatile storage for achieving highly available metadata service, as well as better performance improvement in metadata processing. As the client file system backs up certain sent metadata requests in its memory, the overhead for handling these backup requests is much smaller than that brought by the metadata server, while it adopts logging or journaling to yield highly available metadata service. The experimental results show that this newly proposed mechanism can significantly improve the speed of metadata processing and render a better I/O data throughput, in contrast to conventional metadata management schemes, that is, logging or journaling on MDS. Besides, a complete metadata recovery can be achieved by replaying the backup logs cached by all involved clients, when the metadata server has crashed or gone into nonoperational state exceptionally.

  18. Log-less metadata management on metadata server for parallel file systems.

    Science.gov (United States)

    Liao, Jianwei; Xiao, Guoqiang; Peng, Xiaoning

    2014-01-01

    This paper presents a novel metadata management mechanism on the metadata server (MDS) for parallel and distributed file systems. In this technique, the client file system backs up the sent metadata requests, which have been handled by the metadata server, so that the MDS does not need to log metadata changes to nonvolatile storage for achieving highly available metadata service, as well as better performance improvement in metadata processing. As the client file system backs up certain sent metadata requests in its memory, the overhead for handling these backup requests is much smaller than that brought by the metadata server, while it adopts logging or journaling to yield highly available metadata service. The experimental results show that this newly proposed mechanism can significantly improve the speed of metadata processing and render a better I/O data throughput, in contrast to conventional metadata management schemes, that is, logging or journaling on MDS. Besides, a complete metadata recovery can be achieved by replaying the backup logs cached by all involved clients, when the metadata server has crashed or gone into nonoperational state exceptionally.

  19. High Risk Posture on Motor-Manual Short Wood Logging System in Acacia mangium Plantation

    Directory of Open Access Journals (Sweden)

    Efi Yuliati Yovi

    2015-06-01

    Full Text Available Motor-manual logging has been considered as the most dominant logging system in Java Island, Indonesia. The system-which consisted of felling, delimbing, bucking, hauling, and transporting activities- involves a combination of stress factors e.q. difficult work postures, generation of force, and lifting techniques. In the other hand, combination of the three is well associated with high risk of work-related musculoskeletal injuries (MSIs, including musculoskeletal disorders. This research aimed to assess difficult work posture on felling, delimbing, bucking, and manually short wood hauling by employing rapid entire body assessment (REBA technique and muscular pain scoring based on the worker's perceive. It was revealed that felling and manual hauling were scored 4 in the REBA action level, indicated very high MSIs risk level, and categorized as “necessary now” for an injury risk preventive action. The workers' pain scoring indicated that low back (spine in general disorders resulting in low back pain has been considered to be the one of the leading safety issues in the felling and manual hauling. Regardless to complex mechanism of how the personal risk and environmental factors associated with manual material handling injuries, job-related factors approach should be underlined in the MSIs prevention initiative in motor-manual logging. Keywords: motor-manual logging, difficult work posture, REBA, MSIs, low back pain

  20. Variability in Accreditation Council for Graduate Medical Education Resident Case Log System practices among orthopaedic surgery residents.

    Science.gov (United States)

    Salazar, Dane; Schiff, Adam; Mitchell, Erika; Hopkinson, William

    2014-02-05

    The Accreditation Council for Graduate Medical Education (ACGME) Resident Case Log System is designed to be a reflection of residents' operative volume and an objective measure of their surgical experience. All operative procedures and manipulations in the operating room, Emergency Department, and outpatient clinic are to be logged into the Resident Case Log System. Discrepancies in the log volumes between residents and residency programs often prompt scrutiny. However, it remains unclear if such disparities truly represent differences in operative experiences or if they are reflections of inconsistent logging practices. The purpose of this study was to investigate individual recording practices among orthopaedic surgery residents prior to August 1, 2011. Orthopaedic surgery residents received a questionnaire on case log practices that was distributed through the Council of Orthopaedic Residency Directors list server. Respondents were asked to respond anonymously about recording practices in different clinical settings as well as types of cases routinely logged. Hypothetical scenarios of common orthopaedic procedures were presented to investigate the differences in the Current Procedural Terminology codes utilized. Two hundred and ninety-eight orthopaedic surgery residents completed the questionnaire; 37% were fifth-year residents, 22% were fourth-year residents, 18% were third-year residents, 15% were second-year residents, and 8% were first-year residents. Fifty-six percent of respondents reported routinely logging procedures performed in the Emergency Department or urgent care setting. Twenty-two percent of participants routinely logged procedures in the clinic or outpatient setting, 20% logged joint injections, and only 13% logged casts or splints applied in the office setting. There was substantial variability in the Current Procedural Terminology codes selected for the seven clinical scenarios. There has been a lack of standardization in case-logging

  1. Manchester code telemetry system for well logging using quasi-parallel inductive-capacitive resonance

    Science.gov (United States)

    Xu, Lijun; Chen, Jianjun; Cao, Zhang; Liu, Xingbin; Hu, Jinhai

    2014-07-01

    In this paper, a quasi-parallel inductive-capacitive (LC) resonance method is proposed to improve the recovery of MIL-STD-1553 Manchester code with several frequency components from attenuated, distorted, and drifted signal for data telemetry in well logging, and corresponding telemetry system is developed. Required resonant frequency and quality factor are derived, and the quasi-parallel LC resonant circuit is established at the receiving end of the logging cable to suppress the low-pass filtering effect caused by the distributed capacitance of the cable and provide balanced pass for all the three frequency components of the Manchester code. The performance of the method for various encoding frequencies and cable lengths at different bit energy to noise density ratios (Eb/No) have been evaluated in the simulation. A 5 km single-core cable used in on-site well logging and various encoding frequencies were employed to verify the proposed telemetry system in the experiment. Results obtained demonstrate that the telemetry system is feasible and effective to improve the code recovery in terms of anti-attenuation, anti-distortion, and anti-drift performances, decrease the bit error rate, and increase the reachable transmission rate and distance greatly.

  2. Manchester code telemetry system for well logging using quasi-parallel inductive-capacitive resonance.

    Science.gov (United States)

    Xu, Lijun; Chen, Jianjun; Cao, Zhang; Liu, Xingbin; Hu, Jinhai

    2014-07-01

    In this paper, a quasi-parallel inductive-capacitive (LC) resonance method is proposed to improve the recovery of MIL-STD-1553 Manchester code with several frequency components from attenuated, distorted, and drifted signal for data telemetry in well logging, and corresponding telemetry system is developed. Required resonant frequency and quality factor are derived, and the quasi-parallel LC resonant circuit is established at the receiving end of the logging cable to suppress the low-pass filtering effect caused by the distributed capacitance of the cable and provide balanced pass for all the three frequency components of the Manchester code. The performance of the method for various encoding frequencies and cable lengths at different bit energy to noise density ratios (Eb/No) have been evaluated in the simulation. A 5 km single-core cable used in on-site well logging and various encoding frequencies were employed to verify the proposed telemetry system in the experiment. Results obtained demonstrate that the telemetry system is feasible and effective to improve the code recovery in terms of anti-attenuation, anti-distortion, and anti-drift performances, decrease the bit error rate, and increase the reachable transmission rate and distance greatly.

  3. suitability of vitek 2 system in identification and susceptibility testing

    African Journals Online (AJOL)

    2014-04-01

    Apr 1, 2014 ... identify bacteria and determine their susceptibility to antimicrobial agents (3). The VITEK® 2 system (bioMérieux) is an automated bacteria identification and antimicrobial sensitivity testing platform that conventionally uses bacteria colonies obtained from cultures of clinical specimens. For blood this means ...

  4. The design and implementation of an automated system for logging clinical experiences using an anesthesia information management system.

    Science.gov (United States)

    Simpao, Allan; Heitz, James W; McNulty, Stephen E; Chekemian, Beth; Brenn, B Randall; Epstein, Richard H

    2011-02-01

    Residents in anesthesia training programs throughout the world are required to document their clinical cases to help ensure that they receive adequate training. Current systems involve self-reporting, are subject to delayed updates and misreported data, and do not provide a practicable method of validation. Anesthesia information management systems (AIMS) are being used increasingly in training programs and are a logical source for verifiable documentation. We hypothesized that case logs generated automatically from an AIMS would be sufficiently accurate to replace the current manual process. We based our analysis on the data reporting requirements of the American College of Graduate Medical Education (ACGME). We conducted a systematic review of ACGME requirements and our AIMS record, and made modifications after identifying data element and attribution issues. We studied 2 methods (parsing of free text procedure descriptions and CPT4 procedure code mapping) to automatically determine ACGME case categories and generated AIMS-based case logs and compared these to assignments made by manual inspection of the anesthesia records. We also assessed under- and overreporting of cases entered manually by our residents into the ACGME website. The parsing and mapping methods assigned cases to a majority of the ACGME categories with accuracies of 95% and 97%, respectively, as compared with determinations made by 2 residents and 1 attending who manually reviewed all procedure descriptions. Comparison of AIMS-based case logs with reports from the ACGME Resident Case Log System website showed that >50% of residents either underreported or overreported their total case counts by at least 5%. The AIMS database is a source of contemporaneous documentation of resident experience that can be queried to generate valid, verifiable case logs. The extent of AIMS adoption by academic anesthesia departments should encourage accreditation organizations to support uploading of AIMS-based case

  5. Log-Tool

    Energy Technology Data Exchange (ETDEWEB)

    2012-05-21

    Log files are typically semi- or un-structured. To be useable for visualization and machine learning, they need to be parsed into a standard, structured format. Log-tool is a tool for facilitating the parsing, structuring, and routing of log files (e.g. intrusion detection long, web server logs, system logs). It consists of three main components: (1) Input – it will input data from files, standard input, and syslog, (2) Parser – it will parse the log file based on regular expressions into structured data (JSNO format), (3) Output – it will output structured data into commonly used formats, including Redis (a database), standard output, and syslog.

  6. Susceptibility of SCADA systems and the energy sector

    Science.gov (United States)

    Goike, Lindsay

    The research in this paper focused on analyzing SCADA systems in the energy sector for susceptibility to cyber attacks, in furtherance of providing suggestions to mitigate current and future cyber attacks. The research will be addressing the questions: how are SCADA systems susceptible to cyber attacks, and what are the suggested ways to mitigate both current and future cyber attacks. The five main categories of security vulnerabilities facing current SCADA systems were found to be: connectivity to the Internet, failure to plan, interdependency of sectors, numerous different types of threats, and outdated software. Some of the recommendations mentioned to mitigate current and future risks were: virtual private networks, risk assessments, increased physical security, updating of software, and firewalls.

  7. http Log Analysis

    DEFF Research Database (Denmark)

    Bøving, Kristian Billeskov; Simonsen, Jesper

    2004-01-01

    This article documents how log analysis can inform qualitative studies concerning the usage of web-based information systems (WIS). No prior research has used http log files as data to study collaboration between multiple users in organisational settings. We investigate how to perform http log...... analysis; what http log analysis says about the nature of collaborative WIS use; and how results from http log analysis may support other data collection methods such as surveys, interviews, and observation. The analysis of log files initially lends itself to research designs, which serve to test...... hypotheses using a quantitative methodology. We show that http log analysis can also be valuable in qualitative research such as case studies. The results from http log analysis can be triangulated with other data sources and for example serve as a means of supporting the interpretation of interview data...

  8. Acoustic reverberation in a logging tool-borehole-saturated porous medium system

    Science.gov (United States)

    Markov, A. M.; Markov, M. G.; Ronquillo Jarillo, G.; Sadovnychiy, S. N.

    2014-03-01

    The influence of the elastic and hydrodynamic properties of a rock on the time attenuation coefficient of an acoustic wave, which is reflected from the borehole wall, is considered using the methods of the mechanics of saturated porous media. The calculations were performed for a system consisting of an acoustic logging tool of a finite with a finite diameter, a fluid-filled borehole, and a porous permeable rock. The performed simulation showed that in rocks with a low hydrodynamic permeability, the acoustic-reverberation time is determined by the acoustic impedance of the borehole wall (product of the rock density and the longitudinal-wave velocity in it). In the case of rocks with a permeability of about several hundred millidarcy, the time signal's attenuation coefficient substantially depends on the rock's permeability.

  9. Storage of sparse files using parallel log-structured file system

    Energy Technology Data Exchange (ETDEWEB)

    Bent, John M.; Faibish, Sorin; Grider, Gary; Torres, Aaron

    2017-11-07

    A sparse file is stored without holes by storing a data portion of the sparse file using a parallel log-structured file system; and generating an index entry for the data portion, the index entry comprising a logical offset, physical offset and length of the data portion. The holes can be restored to the sparse file upon a reading of the sparse file. The data portion can be stored at a logical end of the sparse file. Additional storage efficiency can optionally be achieved by (i) detecting a write pattern for a plurality of the data portions and generating a single patterned index entry for the plurality of the patterned data portions; and/or (ii) storing the patterned index entries for a plurality of the sparse files in a single directory, wherein each entry in the single directory comprises an identifier of a corresponding sparse file.

  10. A portable borehole temperature logging system using the four-wire resistance method

    Science.gov (United States)

    Erkan, Kamil; Akkoyunlu, Bülent; Balkan, Elif; Tayanç, Mete

    2017-12-01

    High-quality temperature–depth information from boreholes with a depth of 100 m or more is used in geothermal studies and in studies of climate change. Electrical wireline tools with thermistor sensors are capable of measuring borehole temperatures with millikelvin resolution. The use of a surface readout mode allows analysis of the thermally conductive state of a borehole, which is especially important for climatic and regional heat flow studies. In this study we describe the design of a portable temperature logging tool that uses the four-wire resistance measurement method. The four-wire method enables the elimination of cable resistance effects, thus allowing millikelvin resolution of temperature data at depth. A preliminary two-wire model of the system is also described. The portability of the tool enables one to collect data from boreholes down to 300 m, even in locations with limited accessibility.

  11. A Measuring System for Well Logging Attitude and a Method of Sensor Calibration

    Directory of Open Access Journals (Sweden)

    Yong Ren

    2014-05-01

    Full Text Available This paper proposes an approach for measuring the azimuth angle and tilt angle of underground drilling tools with a MEMS three-axis accelerometer and a three-axis fluxgate sensor. A mathematical model of well logging attitude angle is deduced based on combining space coordinate transformations and algebraic equations. In addition, a system implementation plan of the inclinometer is given in this paper, which features low cost, small volume and integration. Aiming at the sensor and assembly errors, this paper analyses the sources of errors, and establishes two mathematical models of errors and calculates related parameters to achieve sensor calibration. The results show that this scheme can obtain a stable and high precision azimuth angle and tilt angle of drilling tools, with the deviation of the former less than ±1.4° and the deviation of the latter less than ±0.1°.

  12. A measuring system for well logging attitude and a method of sensor calibration.

    Science.gov (United States)

    Ren, Yong; Wang, Yangdong; Wang, Mijian; Wu, Sheng; Wei, Biao

    2014-05-23

    This paper proposes an approach for measuring the azimuth angle and tilt angle of underground drilling tools with a MEMS three-axis accelerometer and a three-axis fluxgate sensor. A mathematical model of well logging attitude angle is deduced based on combining space coordinate transformations and algebraic equations. In addition, a system implementation plan of the inclinometer is given in this paper, which features low cost, small volume and integration. Aiming at the sensor and assembly errors, this paper analyses the sources of errors, and establishes two mathematical models of errors and calculates related parameters to achieve sensor calibration. The results show that this scheme can obtain a stable and high precision azimuth angle and tilt angle of drilling tools, with the deviation of the former less than ±1.4° and the deviation of the latter less than ±0.1°.

  13. A depth video sensor-based life-logging human activity recognition system for elderly care in smart indoor environments.

    Science.gov (United States)

    Jalal, Ahmad; Kamal, Shaharyar; Kim, Daijin

    2014-07-02

    Recent advancements in depth video sensors technologies have made human activity recognition (HAR) realizable for elderly monitoring applications. Although conventional HAR utilizes RGB video sensors, HAR could be greatly improved with depth video sensors which produce depth or distance information. In this paper, a depth-based life logging HAR system is designed to recognize the daily activities of elderly people and turn these environments into an intelligent living space. Initially, a depth imaging sensor is used to capture depth silhouettes. Based on these silhouettes, human skeletons with joint information are produced which are further used for activity recognition and generating their life logs. The life-logging system is divided into two processes. Firstly, the training system includes data collection using a depth camera, feature extraction and training for each activity via Hidden Markov Models. Secondly, after training, the recognition engine starts to recognize the learned activities and produces life logs. The system was evaluated using life logging features against principal component and independent component features and achieved satisfactory recognition rates against the conventional approaches. Experiments conducted on the smart indoor activity datasets and the MSRDailyActivity3D dataset show promising results. The proposed system is directly applicable to any elderly monitoring system, such as monitoring healthcare problems for elderly people, or examining the indoor activities of people at home, office or hospital.

  14. Multi-Threaded Evolution of the Data-Logging System of the ATLAS Experiment at CERN

    CERN Document Server

    Colombo, T; The ATLAS collaboration

    2011-01-01

    The ATLAS experiment observes proton-proton collisions delivered by the LHC accelerator at a centre of mass energy of 7 TeV with a peak luminosity of ~ 10^33 cm^-2 s^-1 in 2011. The ATLAS Trigger and Data Acquisition (TDAQ) system selects interesting events on-line in a three-level trigger system in order to store them at a budgeted average rate of ~ 400 Hz for an event size of ~1.2 MB. This paper focuses on the TDAQ data-logging system. Its purpose is to receive events from the third level trigger, process them and stream the data into different raw files according to the trigger decision. The system currently in production is based on an essentially single-threaded design that is anticipated not to cope with the increase in event rate and event size foreseen as part of the ATLAS and LHC upgrade programs. This design also severely limits the possibility of performing additional CPU-intensive tasks. Therefore, a novel design able to exploit the full power of multi-core architecture is needed. The main challen...

  15. Multi-Threaded Evolution of the Data-Logging System of the ATLAS Experiment at CERN

    CERN Document Server

    Colombo, T; The ATLAS collaboration

    2011-01-01

    The ATLAS experiment is currently observing proton-proton collisions delivered by the LHC accelerator at a centre of mass energy of 7 TeV with a peak luminosity of ~1033 cm-2 s-1. The ATLAS Trigger and Data Acquisition (TDAQ) system selects interesting events on-line in a three-level trigger system in order to store them at a budgeted rate of ~200 Hz for an event size of ~1.5 MB. This paper focuses on the TDAQ data-logging system. Its purpose is to receive events from the third level trigger, process them and stream the results into different raw data files according to the trigger decision. The data files are subsequently moved to the central mass storage facility at CERN. The system currently in production has been commissioned in 2007 and has been working smoothly since then. It is however based on an essentially single-threaded design that is anticipated not to cope with the increase in event rate and event size that is foreseen as part of the ATLAS and LHC upgrade programs. This design also severely limi...

  16. Inertial Navigation System/Doppler Velocity Log (INS/DVL Fusion with Partial DVL Measurements

    Directory of Open Access Journals (Sweden)

    Asaf Tal

    2017-02-01

    Full Text Available The Technion autonomous underwater vehicle (TAUV is an ongoing project aiming to develop and produce a small AUV to carry on research missions, including payload dropping, and to demonstrate acoustic communication. Its navigation system is based on an inertial navigation system (INS aided by a Doppler velocity log (DVL, magnetometer, and pressure sensor (PS. In many INSs, such as the one used in TAUV, only the velocity vector (provided by the DVL can be used for aiding the INS, i.e., enabling only a loosely coupled integration approach. In cases of partial DVL measurements, such as failure to maintain bottom lock, the DVL cannot estimate the vehicle velocity. Thus, in partial DVL situations no velocity data can be integrated into the TAUV INS, and as a result its navigation solution will drift in time. To circumvent that problem, we propose a DVL-based vehicle velocity solution using the measured partial raw data of the DVL and additional information, thereby deriving an extended loosely coupled (ELC approach. The implementation of the ELC approach requires only software modification. In addition, we present the TAUV six degrees of freedom (6DOF simulation that includes all functional subsystems. Using this simulation, the proposed approach is evaluated and the benefit of using it is shown.

  17. AC susceptibility of the Fe(Al, Co) system

    Science.gov (United States)

    Abu-Aljarayesh, I.; Al-Hussein, K.

    1993-08-01

    The temperature and field dependence of the low-field ac susceptibility of the FeAl 1- xCo x (for 0.1 ≤ x ≤ 0.45) system are studied in the temperature range 160-300 K. The results of the κ'- T curves show broad maxima for samples with x ≤ 0.3. The positions of the maxima for samples with x = 0.25 and 0.3 show a weak frequency dependence. For samples with x ≥ 0.3 the susceptibility continues to increase with temperature in the range studied. When an external transverse dc magnetic field is applied, κ' decreases rapidly with increasing the magnitude of the dc field for all studied samples. The obtained paramagnetic temperature θ p, increases rapidly with x. The results are discussed within the context of the Néel theory of superparamagnetism. The environmental effects on the magnetic moment of Fe and Co atoms are used to interpret the results.

  18. An initial log analysis of usage patterns on a research networking system.

    Science.gov (United States)

    Boland, Mary Regina; Trembowelski, Sylvia; Bakken, Suzanne; Weng, Chunhua

    2012-08-01

    Usage data for research networking systems (RNSs) are valuable but generally unavailable for understanding scientific professionals' information needs and online collaborator seeking behaviors. This study contributes a method for evaluating RNSs and initial usage knowledge of one RNS obtained from using this method. We designed a log for an institutional RNS, defined categories of users and tasks, and analyzed correlations between usage patterns and user and query types. Our results show that scientific professionals spend more time performing deep Web searching on RNSs than generic Google users and we also show that retrieving scientist profiles is faster on an RNS than on Google (3.5 seconds vs. 34.2 seconds) whereas organization-specific browsing on a RNS takes longer than on Google (117.0 seconds vs. 34.2 seconds). Usage patterns vary by user role, e.g., faculty performed more informational queries than administrators, which implies role-specific user support is needed for RNSs. © 2012 Wiley Periodicals, Inc.

  19. TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis.

    Directory of Open Access Journals (Sweden)

    Carlos López-Gómez

    Full Text Available The TNF-related apoptosis inducing ligand (TRAIL/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in autoimmune diseases. Thus, TRAIL and TRAIL receptor genes are potential candidates for involvement in susceptibility to multiple sclerosis (MS. To test whether single-nucleotide polymorphisms (SNPs in the human genes encoding TRAIL, TRAILR-1, TRAILR-2, TRAILR-3 and TRAILR-4 are associated with MS susceptibility, we performed a candidate gene case-control study in the Spanish population. 59 SNPs in the TRAIL and TRAIL receptor genes were analysed in 628 MS patients and 660 controls, and validated in an additional cohort of 295 MS patients and 233 controls. Despite none of the SNPs withstood the highly conservative Bonferroni correction, three SNPs showing uncorrected p values<0.05 were successfully replicated: rs4894559 in TRAIL gene, p = 9.8×10(-4, OR = 1.34; rs4872077, in TRAILR-1 gene, p = 0.005, OR = 1.72; and rs1001793 in TRAILR-2 gene, p = 0.012, OR = 0.84. The combination of the alleles G/T/A in these SNPs appears to be associated with a reduced risk of developing MS (p = 2.12×10(-5, OR = 0.59. These results suggest that genes of the TRAIL/TRAIL receptor system exerts a genetic influence on MS.

  20. A case study assessing opportunity costs and ecological benefits of streamside management zones and logging systems for eastern hardwood forests

    Science.gov (United States)

    Chris B. LeDoux; Ethel Wilkerson

    2006-01-01

    Forest landowners, managers, loggers, land-use planners, and other decision and policy-makers need to understand the opportunity costs and ecological benefits associated with different widths of streamside management zones (SMZs). In this paper, a simulation model was used to assess the opportunity costs of SMZ retention for four different logging systems, two mature...

  1. Evaluation of Simple Causal Message Logging for Large-Scale Fault Tolerant HPC Systems

    Energy Technology Data Exchange (ETDEWEB)

    Bronevetsky, G; Meneses, E; Kale, L V

    2011-02-25

    The era of petascale computing brought machines with hundreds of thousands of processors. The next generation of exascale supercomputers will make available clusters with millions of processors. In those machines, mean time between failures will range from a few minutes to few tens of minutes, making the crash of a processor the common case, instead of a rarity. Parallel applications running on those large machines will need to simultaneously survive crashes and maintain high productivity. To achieve that, fault tolerance techniques will have to go beyond checkpoint/restart, which requires all processors to roll back in case of a failure. Incorporating some form of message logging will provide a framework where only a subset of processors are rolled back after a crash. In this paper, we discuss why a simple causal message logging protocol seems a promising alternative to provide fault tolerance in large supercomputers. As opposed to pessimistic message logging, it has low latency overhead, especially in collective communication operations. Besides, it saves messages when more than one thread is running per processor. Finally, we demonstrate that a simple causal message logging protocol has a faster recovery and a low performance penalty when compared to checkpoint/restart. Running NAS Parallel Benchmarks (CG, MG and BT) on 1024 processors, simple causal message logging has a latency overhead below 5%.

  2. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.

    Science.gov (United States)

    Sanchez, Elena; Nadig, Ajay; Richardson, Bruce C; Freedman, Barry I; Kaufman, Kenneth M; Kelly, Jennifer A; Niewold, Timothy B; Kamen, Diane L; Gilkeson, Gary S; Ziegler, Julie T; Langefeld, Carl D; Alarcón, Graciela S; Edberg, Jeffrey C; Ramsey-Goldman, Rosalind; Petri, Michelle; Brown, Elizabeth E; Kimberly, Robert P; Reveille, John D; Vilá, Luis M; Merrill, Joan T; Anaya, Juan-Manuel; James, Judith A; Pons-Estel, Bernardo A; Martin, Javier; Park, So-Yeon; Bang, So-Young; Bae, Sang-Cheol; Moser, Kathy L; Vyse, Timothy J; Criswell, Lindsey A; Gaffney, Patrick M; Tsao, Betty P; Jacob, Chaim O; Harley, John B; Alarcón-Riquelme, Marta E; Sawalha, Amr H

    2011-10-01

    Systemic lupus erythematosus is a clinically heterogeneous autoimmune disease. A number of genetic loci that increase lupus susceptibility have been established. This study examines if these genetic loci also contribute to the clinical heterogeneity in lupus. 4001 European-derived, 1547 Hispanic, 1590 African-American and 1191 Asian lupus patients were genotyped for 16 confirmed lupus susceptibility loci. Ancestry informative markers were genotyped to calculate and adjust for admixture. The association between the risk allele in each locus was determined and compared in patients with and without the various clinical manifestations included in the ACR criteria. Renal disorder was significantly correlated with the lupus risk allele in ITGAM (p=5.0 × 10(-6), OR 1.25, 95% CI 1.12 to 1.35) and in TNFSF4 (p=0.0013, OR 1.14, 95% CI 1.07 to 1.25). Other significant findings include the association between risk alleles in FCGR2A and malar rash (p=0.0031, OR 1.11, 95% CI 1.17 to 1.33), ITGAM and discoid rash (p=0.0020, OR 1.20, 95% CI 1.06 to 1.33), STAT4 and protection from oral ulcers (p=0.0027, OR 0.89, 95% CI 0.83 to 0.96) and IL21 and haematological disorder (p=0.0027, OR 1.13, 95% CI 1.04 to 1.22). All these associations are significant with a false discovery rate of manifestations and the FCGR2A, ITGAM, STAT4, TNSF4 and IL21 genes. The findings suggest that genetic profiling might be a useful tool to predict disease manifestations in lupus patients in the future.

  3. A Computer Vision System forLocating and Identifying Internal Log Defects Using CT Imagery

    Science.gov (United States)

    Dongping Zhu; Richard W. Conners; Frederick Lamb; Philip A. Araman

    1991-01-01

    A number of researchers have shown the ability of magnetic resonance imaging (MRI) and computer tomography (CT) imaging to detect internal defects in logs. However, if these devices are ever to play a role in the forest products industry, automatic methods for analyzing data from these devices must be developed. This paper reports research aimed at developing a...

  4. Nondestructive rule-based defect detection and identification system in CT images of hardwood logs

    Science.gov (United States)

    Erol Sarigul; A. Lynn Abbott; Daniel L. Schmoldt

    2001-01-01

    This paper is concerned with the detection of internal defects in hardwood logs. Because the commercial value of hardwood lumber is directly related to the quantity, type, and location of defects in the wood, sawing strategies are typically chosen in an attempt to minimize the defects in the resulting boards. Traditionally, the sawyer makes sawing decisions by visually...

  5. A transdisciplinary approach to developing a web-based nursing experiential log system for advanced practice nursing clinical experiences.

    Science.gov (United States)

    Olson, Brandon D; Fauchald, Sally K

    2011-11-01

    This article describes a transdisciplinary project between the computer information systems department and the graduate nursing department of a higher education institution. The project is the planning, development, and implementation of a Web-based nursing experiential log system for advanced practice nursing clinical experiences, which was funded by a Nursing Education Practice and Retention grant from the Health Resources and Services Administration. The article explains the concept and benefits of the transdisciplinary nature of the project. The design team, project leadership, and roles within the team are reviewed, including the role of end-user faculty in the design process. The article describes the focus and scope of the Web-based experiential log system database that is used to document and track advanced practice nursing student clinical experiences, as well as a summary of the design process used to develop the log system and the specific functionality of the database system. The implementation process, including end-user training, pilot implementation, and modifications, lessons learned, and future directions of the project are addressed. The article concludes with the benefits to the clinical experience and graduate nursing program that have been noted since the implementation of the system.

  6. Prediction of Compressional, Shear, and Stoneley Wave Velocities from Conventional Well Log Data Using a Committee Machine with Intelligent Systems

    Science.gov (United States)

    Asoodeh, Mojtaba; Bagheripour, Parisa

    2012-01-01

    Measurement of compressional, shear, and Stoneley wave velocities, carried out by dipole sonic imager (DSI) logs, provides invaluable data in geophysical interpretation, geomechanical studies and hydrocarbon reservoir characterization. The presented study proposes an improved methodology for making a quantitative formulation between conventional well logs and sonic wave velocities. First, sonic wave velocities were predicted from conventional well logs using artificial neural network, fuzzy logic, and neuro-fuzzy algorithms. Subsequently, a committee machine with intelligent systems was constructed by virtue of hybrid genetic algorithm-pattern search technique while outputs of artificial neural network, fuzzy logic and neuro-fuzzy models were used as inputs of the committee machine. It is capable of improving the accuracy of final prediction through integrating the outputs of aforementioned intelligent systems. The hybrid genetic algorithm-pattern search tool, embodied in the structure of committee machine, assigns a weight factor to each individual intelligent system, indicating its involvement in overall prediction of DSI parameters. This methodology was implemented in Asmari formation, which is the major carbonate reservoir rock of Iranian oil field. A group of 1,640 data points was used to construct the intelligent model, and a group of 800 data points was employed to assess the reliability of the proposed model. The results showed that the committee machine with intelligent systems performed more effectively compared with individual intelligent systems performing alone.

  7. Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Garred, P; Madsen, H O; Halberg, P

    1999-01-01

    To determine whether variant alleles in the coding portion of the mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections.......To determine whether variant alleles in the coding portion of the mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections....

  8. A graphical automated detection system to locate hardwood log surface defects using high-resolution three-dimensional laser scan data

    Science.gov (United States)

    Liya Thomas; R. Edward. Thomas

    2011-01-01

    We have developed an automated defect detection system and a state-of-the-art Graphic User Interface (GUI) for hardwood logs. The algorithm identifies defects at least 0.5 inch high and at least 3 inches in diameter on barked hardwood log and stem surfaces. To summarize defect features and to build a knowledge base, hundreds of defects were measured, photographed, and...

  9. Suitability of Vitek 2 System in Identification and Susceptibility ...

    African Journals Online (AJOL)

    Objective: To verify the accuracy of direct Vitek testing for blood cultures with Gramnegative bacilli. Design: Validation study. Setting: Aga Khan University Hospital Nairobi. Subjects: Twenty two positive blood cultures. Main outcome measures: Correct bacteria identification and errors for susceptibility testing. Results: Of the ...

  10. suitability of vitek 2 system in identification and susceptibility testing

    African Journals Online (AJOL)

    2014-04-01

    Apr 1, 2014 ... Infection of the bloodstream remains a life-threatening occurrence. Blood cultures and their microbiological analysis are essential for the diagnosis of this infection. (1,2). Rapid detection, identification, and antimicrobial susceptibility testing (AST) of bacteria from blood are crucial in patient management.

  11. 21 CFR 866.1645 - Fully automated short-term incubation cycle antimicrobial susceptibility system.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Fully automated short-term incubation cycle antimicrobial susceptibility system. 866.1645 Section 866.1645 Food and Drugs FOOD AND DRUG ADMINISTRATION... determining in vitro susceptibility of bacterial pathogens isolated from clinical specimens. Test results...

  12. Prediction of susceptibility to the porcine stress syndrome.

    Science.gov (United States)

    Mabry, J W; Christian, L L; Kuhlers, D L; Rasmusen, B A

    1983-01-01

    An experiment designed to compare different predictors of porcine stress syndrome (PSS) was conducted. Animals were exposed to the anesthetic gas, halothane, and their reactions monitored to determine susceptibility or resistance to PSS. Two blood creatine phosphokinase (CPK) traits plus their logs10 were examined as predictors of PSS susceptibility. These were Sigma CPK, Antonik CPK, log Sigma CPK, and log Antonik CPK. The accuracy of these predictors varied from 87 percent to 91 percent in agreement with halothane-determined stress susceptibility. In addition, the relationship of PSS and blood types systems (AO,H) were studied. Two blood types, (+,-/-) and (-,+/+), were consistently stress susceptible while three blood types, (+,a/a), (+,a/c), and (+,c/-), were consistently stress resistant. However, one blood type (+,a/-) contained both stress-susceptible and stress-resistant individuals.

  13. EVALUATION OF VITEK 2 SYSTEM FOR CLINICAL IDENTIFICATION OF CANDIDA SPECIES AND THEIR ANTIFUNGAL SUSCEPTIBILITY TEST

    OpenAIRE

    Mohan; Ram Murugan

    2016-01-01

    BJECTIVES 1. To evaluate the Vitek 2 system for clinical identification of Candida species and their antifungal susceptibility test; 2. To study the incidence of various types of Candida species in this part of Tamilnadu. METHODS Samples collected from different wards were subjected for culture, isolation and identification of Candida Species and Antifungal Susceptibility testing by Vitek System. Vitek 2 test was carried out in Apollo Specialty Hospital Lab Services, Madurai....

  14. System-level analysis of single event upset susceptibility in RRAM architectures

    Science.gov (United States)

    Liu, Rui; Barnaby, Hugh J.; Yu, Shimeng

    2016-12-01

    In this work, the single event upset susceptibility of a resistive random access memory (RRAM) system with 1-transistor-1-resistor (1T1R) and crossbar architectures to heavy ion strikes is investigated from the circuit-level to the system-level. From a circuit-level perspective, the 1T1R is only susceptible to single-bit-upset (SBU) due to the isolation of cells, while in the crossbar, multiple-bit-upsets may occur because ion-induced voltage spikes generated on drivers may propagate along rows or columns. Three factors are considered to evaluate system-level susceptibility: the upset rate, the sensitive area, and the vulnerable time window. Our analysis indicates that the crossbar architecture has a smaller maximum bit-error-rate per day as compared to the 1T1R architecture for a given sub-array size, I/O width and susceptible time window.

  15. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.

    Science.gov (United States)

    Chung, Sharon A; Brown, Elizabeth E; Williams, Adrienne H; Ramos, Paula S; Berthier, Celine C; Bhangale, Tushar; Alarcon-Riquelme, Marta E; Behrens, Timothy W; Criswell, Lindsey A; Graham, Deborah Cunninghame; Demirci, F Yesim; Edberg, Jeffrey C; Gaffney, Patrick M; Harley, John B; Jacob, Chaim O; Kamboh, M Ilyas; Kelly, Jennifer A; Manzi, Susan; Moser-Sivils, Kathy L; Russell, Laurie P; Petri, Michelle; Tsao, Betty P; Vyse, Tim J; Zidovetzki, Raphael; Kretzler, Matthias; Kimberly, Robert P; Freedman, Barry I; Graham, Robert R; Langefeld, Carl D

    2014-12-01

    Lupus nephritis is a manifestation of SLE resulting from glomerular immune complex deposition and inflammation. Lupus nephritis demonstrates familial aggregation and accounts for significant morbidity and mortality. We completed a meta-analysis of three genome-wide association studies of SLE to identify lupus nephritis-predisposing loci. Through genotyping and imputation, >1.6 million markers were assessed in 2000 unrelated women of European descent with SLE (588 patients with lupus nephritis and 1412 patients with lupus without nephritis). Tests of association were computed using logistic regression adjusting for population substructure. The strongest evidence for association was observed outside the MHC and included markers localized to 4q11-q13 (PDGFRA, GSX2; P=4.5×10(-7)), 16p12 (SLC5A11; P=5.1×10(-7)), 6p22 (ID4; P=7.4×10(-7)), and 8q24.12 (HAS2, SNTB1; P=1.1×10(-6)). Both HLA-DR2 and HLA-DR3, two well established lupus susceptibility loci, showed evidence of association with lupus nephritis (P=0.06 and P=3.7×10(-5), respectively). Within the class I region, rs9263871 (C6orf15-HCG22) had the strongest evidence of association with lupus nephritis independent of HLA-DR2 and HLA-DR3 (P=8.5×10(-6)). Consistent with a functional role in lupus nephritis, intra-renal mRNA levels of PDGFRA and associated pathway members showed significant enrichment in patients with lupus nephritis (n=32) compared with controls (n=15). Results from this large-scale genome-wide investigation of lupus nephritis provide evidence of multiple biologically relevant lupus nephritis susceptibility loci. Copyright © 2014 by the American Society of Nephrology.

  16. Parallel compression of data chunks of a shared data object using a log-structured file system

    Science.gov (United States)

    Bent, John M.; Faibish, Sorin; Grider, Gary

    2016-10-25

    Techniques are provided for parallel compression of data chunks being written to a shared object. A client executing on a compute node or a burst buffer node in a parallel computing system stores a data chunk generated by the parallel computing system to a shared data object on a storage node by compressing the data chunk; and providing the data compressed data chunk to the storage node that stores the shared object. The client and storage node may employ Log-Structured File techniques. The compressed data chunk can be de-compressed by the client when the data chunk is read. A storage node stores a data chunk as part of a shared object by receiving a compressed version of the data chunk from a compute node; and storing the compressed version of the data chunk to the shared data object on the storage node.

  17. A Strapdown Interial Navigation System/Beidou/Doppler Velocity Log Integrated Navigation Algorithm Based on a Cubature Kalman Filter

    Directory of Open Access Journals (Sweden)

    Wei Gao

    2014-01-01

    Full Text Available The integrated navigation system with strapdown inertial navigation system (SINS, Beidou (BD receiver and Doppler velocity log (DVL can be used in marine applications owing to the fact that the redundant and complementary information from different sensors can markedly improve the system accuracy. However, the existence of multisensor asynchrony will introduce errors into the system. In order to deal with the problem, conventionally the sampling interval is subdivided, which increases the computational complexity. In this paper, an innovative integrated navigation algorithm based on a Cubature Kalman filter (CKF is proposed correspondingly. A nonlinear system model and observation model for the SINS/BD/DVL integrated system are established to more accurately describe the system. By taking multi-sensor asynchronization into account, a new sampling principle is proposed to make the best use of each sensor’s information. Further, CKF is introduced in this new algorithm to enable the improvement of the filtering accuracy. The performance of this new algorithm has been examined through numerical simulations. The results have shown that the positional error can be effectively reduced with the new integrated navigation algorithm. Compared with the traditional algorithm based on EKF, the accuracy of the SINS/BD/DVL integrated navigation system is improved, making the proposed nonlinear integrated navigation algorithm feasible and efficient.

  18. pLog enterprise-enterprise GIS-based geotechnical data management system enhancements.

    Science.gov (United States)

    2015-12-01

    Recent eorts by the Louisiana Department of Transportation and Development (DOTD) and the : Louisiana Transportation Research Center (LTRC) have developed a Geotechnical Information : Database, with a Geographic Information System (GIS) interface....

  19. Wolbachia increases susceptibility to Plasmodium infection in a natural system

    Science.gov (United States)

    Zélé, F.; Nicot, A.; Berthomieu, A.; Weill, M.; Duron, O.; Rivero, A.

    2014-01-01

    Current views about the impact of Wolbachia on Plasmodium infections are almost entirely based on data regarding artificially transfected mosquitoes. This work has shown that Wolbachia reduces the intensity of Plasmodium infections in mosquitoes, raising the exciting possibility of using Wolbachia to control or limit the spread of malaria. Whether natural Wolbachia infections have the same parasite-inhibiting properties is not yet clear. Wolbachia–mosquito combinations with a long evolutionary history are, however, key for understanding what may happen with Wolbachia-transfected mosquitoes after several generations of coevolution. We investigate this issue using an entirely natural mosquito–Wolbachia–Plasmodium combination. In contrast to most previous studies, which have been centred on the quantification of the midgut stages of Plasmodium, we obtain a measurement of parasitaemia that relates directly to transmission by following infections to the salivary gland stages. We show that Wolbachia increases the susceptibility of Culex pipiens mosquitoes to Plasmodium relictum, significantly increasing the prevalence of salivary gland stage infections. This effect is independent of the density of Wolbachia in the mosquito. These results suggest that naturally Wolbachia-infected mosquitoes may, in fact, be better vectors of malaria than Wolbachia-free ones. PMID:24500167

  20. LogAmp electronics and Optical Transmission for the new SPS Beam Position Measurement System

    CERN Document Server

    Deplano, C; Gonzalez, J L; Savioz, J J

    2013-01-01

    A new front-end board is under development for the CERN SPS Multi ORbit Position System (MOPOS). Based on logarithmic amplifiers, it measures the beam position over a large dynamic range of beam intensities and resolves the multi-batch structure of the SPS beams. Analogue data are digitized at 10 MS/s, packed in frames by an FPGA and on every turn sent to the readout board, via a 2.4 Gb/s optical transmission link. A first prototype has been successfully tested with several SPS beams. This paper presents an overall description of the system and its capabilities highlighted by the first beam measurements.

  1. Antimicrobial susceptibility of foodborne pathogens in organic or natural production systems: an overview.

    Science.gov (United States)

    Jacob, Megan E; Fox, James Trent; Reinstein, Shelby L; Nagaraja, T G

    2008-12-01

    Organic and natural food production systems are increasing in popularity, at least partially because consumers perceive that these niche markets provide healthier and safer food products. One major difference between these niche markets and conventional production systems is the use of antimicrobials. Because antimicrobial agents exert selective pressures for antimicrobial resistance, relating antimicrobial susceptibility of foodborne bacteria to niche market production systems is of interest. Other differences between production systems might also influence the susceptibility of foodborne pathogens. The objective of this review is to compare the impact of food animal production systems on the antimicrobial susceptibility of common foodborne bacterial pathogens. Studies comparing the susceptibility of such pathogens were diverse in terms of geographic location, procedures, species of bacteria, and antimicrobials evaluated; thus, it was difficult to draw conclusions. The literature is highly variable in terms of production type and practices and susceptibility associations, although few studies have compared truly organic and conventional practices. When statistical associations were found between production type and minimum inhibitory concentrations or percentage of isolates resistant for a particular pathogen, the isolates from conventionally reared animals/products were more commonly resistant than the comparison group (organic, antibiotic free, etc.). Therefore, further studies are needed to better assess public health consequences of antimicrobial resistance and food animal production systems, specifically organic or natural versus conventional.

  2. Perancangan dan Realisasi Web-Based Data Logging System menggunakan ATmega16 melalui Hypertext Transfer Protocol (HTTP

    Directory of Open Access Journals (Sweden)

    RATNA SUSANA

    2016-02-01

    Full Text Available Abstrak Hypertext Transfer Protocol (HTTP merupakan protokol jaringan pada lapisan aplikasi TCP/IP yang menjadi dasar komunikasi pada World Wide Web (WWW. Penelitian ini merancang dan merealisasikan web-based data logging system yang bertujuan untuk memperkenalkan aturan HTTP, sehingga perangkat elektronik dapat berkomunikasi dengan website secara langsung. Sistem dirancang dengan dua sub sistem utama yaitu website data logger dan website. Data logger direalisasikan menggunakan ATMega16 yang diintegrasikan dengan sumber data analog dan digital, RTC serta modem GSM. Data logger berfungsi sebagai pengirim data, sedangkan website berfungsi sebagai pengatur, penerima, pengolah dan penyaji data. Sistem ini telah berhasil melakukan komunikasi antara data logger dengan website melalui HTTP, artinya protokol ini dapat diimplementasikan pada data logger yang menggunakan ATmega16. Perubahan data analog dan status logika 0 dan 1 dari data digital yang terjadi pada data logger dapat dilihat pada tampilan di website. Kata kunci:  basis data, data logger, Hypertext Transfer Protocol (HTTP, website, protokol jaringan. Abstract Hypertext Transfer Protocol (HTTP is an application layer network protocols in TCP/IP is the basis of communication on the World Wide Web (WWW. This research was to design and realize a web-based data logging system that aims to introduce the rules of HTTP, so that electronic devices could communicate with the website directly. The system was designed with two main sub-system, namely data logger and website. The data logger was realized using ATmega16 are integrated with analog and digital data sources, RTC and a GSM modem. Data logger function as the sender of data, while the website functions as regulator, receiver, processing and presenter data. This system had been successfully perform communication between the data logger to a website via HTTP, meaning that this protocol could be implemented on a data logger that uses ATmega16

  3. Statistical Characterization of School Bus Drive Cycles Collected via Onboard Logging Systems

    Energy Technology Data Exchange (ETDEWEB)

    Duran, A.; Walkowicz, K.

    2013-10-01

    In an effort to characterize the dynamics typical of school bus operation, National Renewable Energy Laboratory (NREL) researchers set out to gather in-use duty cycle data from school bus fleets operating across the country. Employing a combination of Isaac Instruments GPS/CAN data loggers in conjunction with existing onboard telemetric systems resulted in the capture of operating information for more than 200 individual vehicles in three geographically unique domestic locations. In total, over 1,500 individual operational route shifts from Washington, New York, and Colorado were collected. Upon completing the collection of in-use field data using either NREL-installed data acquisition devices or existing onboard telemetry systems, large-scale duty-cycle statistical analyses were performed to examine underlying vehicle dynamics trends within the data and to explore vehicle operation variations between fleet locations. Based on the results of these analyses, high, low, and average vehicle dynamics requirements were determined, resulting in the selection of representative standard chassis dynamometer test cycles for each condition. In this paper, the methodology and accompanying results of the large-scale duty-cycle statistical analysis are presented, including graphical and tabular representations of a number of relationships between key duty-cycle metrics observed within the larger data set. In addition to presenting the results of this analysis, conclusions are drawn and presented regarding potential applications of advanced vehicle technology as it relates specifically to school buses.

  4. Microdevice's susceptibility difference based MRI positioning system, a preliminary investigation.

    Science.gov (United States)

    Felfoul, O; Martel, S; Beaudoin, G; Mathieu, J-B

    2004-01-01

    A positioning technique for an endovascular microdevice propelled by magnetic force inside a magnetic resonance imaging (MRI) system is being developed. Positioning options are presented and a magnetic positioning technique is described in more details. Since a magnetic positioning system is deeply dependent on the quality of the measurement modality, we describe the main magnetic field measurement techniques that can be used inside an MRI. Finally, we propose a magnetic positioning system using MRI phase images to measure the magnetic distortion induced by the ferromagnetic body. Positioning results on a 1010/1020 carbon steel, 1.5875 mm diameter sphere with gradient echo phase images are presented.

  5. Rotor-System Log-Decrement Identification Using Short-Time Fourier-Transform Filter

    Directory of Open Access Journals (Sweden)

    Qihang Li

    2015-01-01

    Full Text Available With the increase of the centrifugal compressor capability, such as large scale LNG and CO2 reinjection, the stability margin evaluation is crucial to assure the compressor work in the designed operating conditions in field. Improving the precision of parameter identification of stability is essential and necessary as well. Based on the time-varying characteristics of response vibration during the sine-swept process, a short-time Fourier transform (STFT filter was introduced to increase the signal-noise ratio and improve the accuracy of the estimated stability parameters. A finite element model was established to simulate the sine-swept process, and the simulated vibration signals were used to study the filtering effect and demonstrate the feasibility to identify the stability parameters by using Multiple-Input and Multiple-Output system identification method that combines the prediction error method and instrumental variable method. Simulation results show that the identification method with STFT filter improves the estimated accuracy much well and makes the curves of frequency response function clearer. Experiment was carried out on a test rig as well, which indicates the identification method is feasible in stability identification, and the results of experiment indicate that STFT filter works very well.

  6. Quantitative calculation of GOR of complex oil-gas-water systems with logging data: A case study of the Yingdong Oil/Gas Field in the Qaidam Basin

    Directory of Open Access Journals (Sweden)

    Sima Liqiang

    2014-12-01

    Full Text Available In the Yingdong Oil/Gas Field of the Qaidam Basin, multiple suites of oil-gas-water systems overlie each other vertically, making it difficult to accurately identify oil layers from gas layers and calculate gas-oil ratio (GOR. Therefore, formation testing and production data, together with conventional logging, NMR and mud logging data were integrated to quantitatively calculate GOR. To tell oil layers from gas layers, conventional logging makes use of the excavation effect of compensated neutron log, NMR makes use of the different relaxation mechanisms of light oil and natural gas in large pores, while mud logging makes use of star chart of gas components established based on available charts and mathematical statistics. In terms of the quantitative calculation of GOR, the area ratio of the star chart of gas components was first used in GOR calculation. The study shows that: (1 conventional logging data has a modest performance in distinguishing oil layers from gas layers due to the impacts of formation pressure, hydrogen index (HI, shale content, borehole conditions and invasion of drilling mud; (2 NMR is quite effective in telling oil layers from gas layers, but cannot be widely used due to its high cost; (3 by contrast, the star chart of gas components is the most effective in differentiating oil layers from gas layers; and (4 the GOR calculated by using the area ratio of star chart has been verified by various data such as formation testing data, production data and liquid production profile.

  7. SU-F-T-172: A Method for Log File QA On An IBA Proteus System for Patient Specific Spot Scanning Quality Assurance

    Energy Technology Data Exchange (ETDEWEB)

    Tang, S; Ho, M; Chen, C; Mah, D [ProCure NJ, Somerset, NJ (United States); Rice, I; Doan, D; Mac Rae, B [IBA, Somerset, NJ (United States)

    2016-06-15

    Purpose: The use of log files to perform patient specific quality assurance for both protons and IMRT has been established. Here, we extend that approach to a proprietary log file format and compare our results to measurements in phantom. Our goal was to generate a system that would permit gross errors to be found within 3 fractions until direct measurements. This approach could eventually replace direct measurements. Methods: Spot scanning protons pass through multi-wire ionization chambers which provide information about the charge, location, and size of each delivered spot. We have generated a program that calculates the dose in phantom from these log files and compares the measurements with the plan. The program has 3 different spot shape models: single Gaussian, double Gaussian and the ASTROID model. The program was benchmarked across different treatment sites for 23 patients and 74 fields. Results: The dose calculated from the log files were compared to those generate by the treatment planning system (Raystation). While the dual Gaussian model often gave better agreement, overall, the ASTROID model gave the most consistent results. Using a 5%–3 mm gamma with a 90% passing criteria and excluding doses below 20% of prescription all patient samples passed. However, the degree of agreement of the log file approach was slightly worse than that of the chamber array measurement approach. Operationally, this implies that if the beam passes the log file model, it should pass direct measurement. Conclusion: We have established and benchmarked a model for log file QA in an IBA proteus plus system. The choice of optimal spot model for a given class of patients may be affected by factors such as site, field size, and range shifter and will be investigated further.

  8. Logging concessions enable illegal logging crisis in the Peruvian Amazon.

    Science.gov (United States)

    Finer, Matt; Jenkins, Clinton N; Sky, Melissa A Blue; Pine, Justin

    2014-04-17

    The Peruvian Amazon is an important arena in global efforts to promote sustainable logging in the tropics. Despite recent efforts to achieve sustainability, such as provisions in the US-Peru Trade Promotion Agreement, illegal logging continues to plague the region. We present evidence that Peru's legal logging concession system is enabling the widespread illegal logging via the regulatory documents designed to ensure sustainable logging. Analyzing official government data, we found that 68.3% of all concessions supervised by authorities were suspected of major violations. Of the 609 total concessions, nearly 30% have been cancelled for violations and we expect this percentage to increase as investigations continue. Moreover, the nature of the violations indicate that the permits associated with legal concessions are used to harvest trees in unauthorized areas, thus threatening all forested areas. Many of the violations pertain to the illegal extraction of CITES-listed timber species outside authorized areas. These findings highlight the need for additional reforms.

  9. Logging Concessions Enable Illegal Logging Crisis in the Peruvian Amazon

    Science.gov (United States)

    Finer, Matt; Jenkins, Clinton N.; Sky, Melissa A. Blue; Pine, Justin

    2014-04-01

    The Peruvian Amazon is an important arena in global efforts to promote sustainable logging in the tropics. Despite recent efforts to achieve sustainability, such as provisions in the US-Peru Trade Promotion Agreement, illegal logging continues to plague the region. We present evidence that Peru's legal logging concession system is enabling the widespread illegal logging via the regulatory documents designed to ensure sustainable logging. Analyzing official government data, we found that 68.3% of all concessions supervised by authorities were suspected of major violations. Of the 609 total concessions, nearly 30% have been cancelled for violations and we expect this percentage to increase as investigations continue. Moreover, the nature of the violations indicate that the permits associated with legal concessions are used to harvest trees in unauthorized areas, thus threatening all forested areas. Many of the violations pertain to the illegal extraction of CITES-listed timber species outside authorized areas. These findings highlight the need for additional reforms.

  10. Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis

    NARCIS (Netherlands)

    Cenit, M.C.; Simeon, C.P.; Vonk, M.C.; Callejas-Rubio, J.L.; Espinosa, G.; Carreira, P.; Blanco, F.J.; Narvaez, J.; Tolosa, C.; Roman-Ivorra, J.A.; Gomez-Garcia, I.; Garcia-Hernandez, F.J.; Gallego, M.; Garcia-Portales, R.; Egurbide, M.V.; Fonollosa, V.; Garcia de la Pena, P.; Lopez-Longo, F.J.; Gonzalez-Gay, M.A.; The Spanish Scleroderma, G.; Hesselstrand, R.; Riemekasten, G.; Witte, T.; Voskuyl, A.E.; Schuerwegh, A.J.; Madhok, R.; Fonseca, C.; Denton, C.; Nordin, A.; Palm, O.; Laar, J.M. van; Hunzelmann, N.; Distler, J.H.; Kreuter, A.; Herrick, A.; Worthington, J.; Koeleman, B.P.; Radstake, T.R.D.J.; Martin, J.

    2012-01-01

    OBJECTIVE: Systemic sclerosis (SSc) is a genetically complex autoimmune disease; the genetic component has not been fully defined. Interleukin 6 (IL-6) plays a crucial role in immunity and fibrosis, both key aspects of SSc. We investigated the influence of IL6 gene in the susceptibility and

  11. Characterization of biofilm growth and biocide susceptibility testing of Mycobacterium phlei using the MBEC assay system.

    Science.gov (United States)

    Bardouniotis, E; Huddleston, W; Ceri, H; Olson, M E

    2001-09-25

    The importance of non-tuberculosis mycobacterial biofilm species in medicine, industry and the environment has recently gained attention. Our objectives were to characterize biofilm growth of Mycobacterium phlei M4, as a model of rapidly growing mycobacteria using the minimal biofilm eradication concentration (MBEC) and to compare biocide susceptibility of planktonic and biofilm organisms. Scanning electron microscopy was also carried out to observe biofilm morphology. With the exception of Sporicidin and Virkon the minimum bactericidal concentration values for all biocides tested were lower than the MBEC values. The MBEC assay system was seen to produce multiple and reproducible biofilms of M. phlei and to be a useful tool for susceptibility studies.

  12. Susceptibility of KSHV-Infected PEL Cell Lines to the Human Complement System.

    Science.gov (United States)

    Yoo, Seung-Min; Jeon, Hyungtaek; Lee, Suhyuk; Lee, Myung-Shin

    2016-03-01

    Pleural effusion lymphoma (PEL) is a rare B-cell lymphoma that has a very poor prognosis with a median survival time of around 6 months. PEL is caused by Kaposi's sarcoma-associated herpesvirus, and is often co-infected with the Epstein Barr virus. The complement system is fundamental in the innate immune system against pathogen invasion and tumor development. In the present study, we investigated the activation of the complement system in PEL cells using human serum complements. Interestingly, two widely used PEL cell lines, BCP-1 and BCBL-1, showed different susceptibility to the complement system, which may be due to CD46 expression on their cell membranes. Complement activation did not induce apoptosis but supported cell survival considerably. Our results demonstrated the susceptibility of PEL to the complement system and its underlying mechanisms, which would provide insight into understanding the pathogenesis of PEL.

  13. Susceptibility and hardening of electronic systems to fast transient threats: new challenges ahead

    Directory of Open Access Journals (Sweden)

    F. Sabath

    2004-01-01

    Full Text Available The field of susceptibility and hardening of electronic systems to transient threats has experienced a significant growth during the past ten years. Driven by the development in the area of non-lethal electromagnetic weapons it has become necessary to extend the classical set of transient threats, consisting of LEMP, ESD and NEMP, by a fast transient threat with an extreme bandwidth. The investigation of the susceptibility to those UWB threats, characterized by a bandwidth of more than a quarter of the center frequency, rise times of less than 200 ps and pulse durations in the ns regime, is of special interest. This paper presents an overview of current challenges of the hardening against UWB threats. It discusses recent research trends in transient susceptibility measurements, protection concepts and methods of analysis.

  14. How Do Patrons Search the Online Catalog When No One's Looking? Transaction Log Analysis and Implications for Bibliographic Instruction and Systems Design.

    Science.gov (United States)

    Wallace, Patricia M.

    1993-01-01

    Describes a study that electronically monitored 11 public access terminals at the University of Colorado libraries to produce transaction logs that were used to gather statistics and analyze users' behavior when searching online catalogs. Implications for search instruction and systems design are suggested. (Contains 13 references.) (LRW)

  15. Long-term responses of rainforest erosional systems at different spatial scales to selective logging and climatic change

    Science.gov (United States)

    Walsh, R. P. D.; Bidin, K.; Blake, W. H.; Chappell, N. A.; Clarke, M. A.; Douglas, I.; Ghazali, R.; Sayer, A. M.; Suhaimi, J.; Tych, W.; Annammala, K. V.

    2011-01-01

    Long-term (21–30 years) erosional responses of rainforest terrain in the Upper Segama catchment, Sabah, to selective logging are assessed at slope, small and large catchment scales. In the 0.44 km2 Baru catchment, slope erosion measurements over 1990–2010 and sediment fingerprinting indicate that sediment sources 21 years after logging in 1989 are mainly road-linked, including fresh landslips and gullying of scars and toe deposits of 1994–1996 landslides. Analysis and modelling of 5–15 min stream-suspended sediment and discharge data demonstrate a reduction in storm-sediment response between 1996 and 2009, but not yet to pre-logging levels. An unmixing model using bed-sediment geochemical data indicates that 49 per cent of the 216 t km−2 a−1 2009 sediment yield comes from 10 per cent of its area affected by road-linked landslides. Fallout 210Pb and 137Cs values from a lateral bench core indicate that sedimentation rates in the 721 km2 Upper Segama catchment less than doubled with initially highly selective, low-slope logging in the 1980s, but rose 7–13 times when steep terrain was logged in 1992–1993 and 1999–2000. The need to keep steeplands under forest is emphasized if landsliding associated with current and predicted rises in extreme rainstorm magnitude-frequency is to be reduced in scale. PMID:22006973

  16. Generalization of susceptibility of RF systems through far-field pattern superposition

    Science.gov (United States)

    Verdin, B.; Debroux, P.

    2015-05-01

    The purpose of this paper is to perform an analysis of RF (Radio Frequency) communication systems in a large electromagnetic environment to identify its susceptibility to jamming systems. We propose a new method that incorporates the use of reciprocity and superposition of the far-field radiation pattern of the RF system and the far-field radiation pattern of the jammer system. By using this method we can find the susceptibility pattern of RF systems with respect to the elevation and azimuth angles. A scenario was modeled with HFSS (High Frequency Structural Simulator) where the radiation pattern of the jammer was simulated as a cylindrical horn antenna. The RF jamming entry point used was a half-wave dipole inside a cavity with apertures that approximates a land-mobile vehicle, the dipole approximates a leaky coax cable. Because of the limitation of the simulation method, electrically large electromagnetic environments cannot be quickly simulated using HFSS's finite element method (FEM). Therefore, the combination of the transmit antenna radiation pattern (horn) superimposed onto the receive antenna pattern (dipole) was performed in MATLAB. A 2D or 3D susceptibility pattern is obtained with respect to the azimuth and elevation angles. In addition, by incorporating the jamming equation into this algorithm, the received jamming power as a function of distance at the RF receiver Pr(Φr, θr) can be calculated. The received power depends on antenna properties, propagation factor and system losses. Test cases include: a cavity with four apertures, a cavity above an infinite ground plane, and a land-mobile vehicle approximation. By using the proposed algorithm a susceptibility analysis of RF systems in electromagnetic environments can be performed.

  17. [Recommendations for selecting antimicrobial agents for in vitro susceptibility studies using automatic and semiautomatic systems].

    Science.gov (United States)

    Cantón, Rafael; Alós, Juan Ignacio; Baquero, Fernando; Calvo, Jorge; Campos, José; Castillo, Javier; Cercenado, Emilia; Domínguez, M Angeles; Liñares, Josefina; López-Cerezo, Lorena; Marco, Francesc; Mirelis, Beatriz; Morosini, María-Isabel; Navarro, Ferran; Oliver, Antonio; Pérez-Trallero, Emilio; Torres, Carmen; Martínez-Martínez, Luis

    2007-01-01

    The number of clinical microbiology laboratories that have incorporated automatic susceptibility testing devices has increased in recent years. The majority of these systems determine MIC values using microdilution panels or specific cards, with grouping into clinical categories (susceptible, intermediate or resistant) and incorporate expert systems to infer resistance mechanisms. This document presents the recommendations of a group of experts designated by Grupo de Estudio de los Mecanismos de Acción y Resistencia a los Antimicrobianos (GEMARA, Study group on mechanisms of action and resistance to antimicrobial agents) and Mesa Española de Normalización de la Sensibilidad y Resistencia a los Antimicrobianos (MENSURA, Spanish Group for Normalizing Antimicrobial Susceptibility and Antimicrobial Resistance), with the aim of including antimicrobial agents and selecting concentrations for the susceptibility testing panels of automatic systems. The following have been defined: various antimicrobial categories (A: must be included in the study panel; B: inclusion is recommended; and C: inclusion is secondary, but may facilitate interpretative reading of the antibiogram) and groups (0: not used in therapeutics but may facilitate the detection of resistance mechanisms; 1: must be studied and always reported; 2: must be studied and selectively reported; 3: must be studied and reported at a second level; and 4: should be studied in urinary tract pathogens isolated in urine and other specimens). Recommended antimicrobial concentrations are adapted from the breakpoints established by EUCAST, CLSI and MENSURA. This approach will lead to more accurate susceptibility testing results with better detection of resistance mechanisms, and allowing to reach the clinical goal of the antibiogram.

  18. Two-Component Systems Involved in Susceptibility to Nisin A in Streptococcus pyogenes.

    Science.gov (United States)

    Kawada-Matsuo, Miki; Tatsuno, Ichiro; Arii, Kaoru; Zendo, Takeshi; Oogai, Yuichi; Noguchi, Kazuyuki; Hasegawa, Tadao; Sonomoto, Kenji; Komatsuzawa, Hitoshi

    2016-10-01

    Two-component systems (TCSs) are regulatory systems in bacteria that play important roles in sensing and adapting to the environment. In this study, we systematically evaluated the roles of TCSs in the susceptibility of the group A Streptococcus (GAS; Streptococcus pyogenes) SF370 strain to several types of lantibiotics. Using individual TCS deletion mutants, we found that the deletion of srtRK (spy_1081-spy_1082) in SF370 increased the susceptibility to nisin A, which is produced by Lactococcus lactis ATCC 11454, but susceptibility to other types of lantibiotics (nukacin ISK-1, produced by Staphylococcus warneri, and staphylococcin C55, produced by Staphylococcus aureus) was not altered in the TCS mutants tested. The expression of srtFEG (spy_1085 to spy_1087), which is located downstream of srtRK and is homologous to ABC transporters, was increased in response to nisin A. However, srtEFG expression was not induced by nisin A in the srtRK mutant. The inactivation of srtFEG increased the susceptibility to nisin A. These results suggest that SrtRK controls SrtFEG expression to alter the susceptibility to nisin A. Further experiments showed that SrtRK is required for coexistence with L. lactis ATCC 11454, which produces nisin A. Our results elucidate the important roles of S. pyogenes TCSs in the interactions between different bacterial species, including bacteriocin-producing bacteria. In this study, we focused on the association of TCSs with susceptibility to bacteriocins in S. pyogenes SF370, which has no ability to produce bacteriocins, and reported two major new findings. We demonstrated that the SrtRK TCS is related to susceptibility to nisin A by controlling the ABC transporter SrtFEG. We also showed that S. pyogenes SrtRK is important for survival when the bacteria are cocultured with nisin A-producing Lactococcus lactis This report highlights the roles of TCSs in the colocalization of bacteriocin-producing bacteria and non-bacteriocin-producing bacteria. Our

  19. Multicenter evaluation of the MB/BACT system for susceptibility testing of Mycobacterium tuberculosis.

    Science.gov (United States)

    Bemer, Pascale; Bodmer, Thomas; Munzinger, Juerg; Perrin, Monique; Vincent, Véronique; Drugeon, Henri

    2004-03-01

    The reliability of the MB/BACT system for susceptibility testing of Mycobacterium tuberculosis to pyrazinamide, rifampin, isoniazid, streptomycin, and ethambutol was compared to the BACTEC 460TB system. The proportion method was used to resolve discrepant results by an independent arbiter. Two interpretative methods were used, with an undiluted control (direct control) and a diluted control (10(-1) control). As no significant difference was observed between the two controls, the method with the direct control was adopted as the most accurate one. One hundred sixty-six strains were tested, with an overall agreement of 98.3%. After resolution of the 18 discrepant results by the proportion method, the sensitivity and specificity of the MB/BACT system were 100% for rifampin, isoniazid, and pyrazinamide. For ethambutol, sensitivity was 92.3% at the critical concentration and 33% at the high concentration, and specificity was 100% at both concentrations. For streptomycin, sensitivity was 100% at the critical concentration and 80% at the high concentration, and specificity was 98.6% at the critical concentration and 100% at the high concentration. The rifampin, isoniazid, streptomycin, and ethambutol susceptibility test results were obtained in 6.6 days with the MB/BACT versus 5 days with the BACTEC 460TB. The pyrazinamide susceptibility test results were obtained in 7.8 days with the MB/BACT, versus 6.7 days with the BACTEC 460TB. These data demonstrate that the fully automated MB/BACT system is a very reliable method for rapid susceptibility testing of M. tuberculosis against rifampin, isoniazid, and pyrazinamide. Sensitivity results have to be improved for ethambutol and streptomycin, especially at the high concentration.

  20. A single tri-axial accelerometer-based real-time personal life log system capable of activity classification and exercise information generation.

    Science.gov (United States)

    Lee, Myong-Woo; Khan, Adil Mehmood; Kim, Ji-Hwan; Cho, Young-Sun; Kim, Tae-Seong

    2010-01-01

    Recording a personal life log (PLL) of daily activities is an emerging technology for u-lifecare and e-health services. In this paper, we present an accelerometer-based personal life log system capable of human activity classification and exercise information generation. In our system, we use a tri-axial accelerometer and a real-time activity recognition scheme in which a set of augmented features of accelerometer signals, processed with Linear Discriminant Analysis (LDA), is classified by our hierarchical artificial neural network classifier: in the lower level of the classifier, a state of an activity is recognized based on the statistical and spectral features; in the upper level, an activity is recognized with a set of augmented features including autoregressive (AR) coefficients, signal magnitude area (SMA), and tilt angles (TA). Upon the recognition of each activity, we further estimate exercise information such as energy expenditure based on Metabolic Equivalents (METS), step count, walking distance, walking speed, activity duration, etc. Our PLL system functions in real-time and all information generated from our system is archived in a daily-log database. By testing our system on seven different daily activities, we have obtained an average accuracy of 84.8% in activity recognition and generated their relative exercise information.

  1. Flood susceptibility mapping using novel ensembles of adaptive neuro fuzzy inference system and metaheuristic algorithms.

    Science.gov (United States)

    Razavi Termeh, Seyed Vahid; Kornejady, Aiding; Pourghasemi, Hamid Reza; Keesstra, Saskia

    2018-02-15

    Flood is one of the most destructive natural disasters which cause great financial and life losses per year. Therefore, producing susceptibility maps for flood management are necessary in order to reduce its harmful effects. The aim of the present study is to map flood hazard over the Jahrom Township in Fars Province using a combination of adaptive neuro-fuzzy inference systems (ANFIS) with different metaheuristics algorithms such as ant colony optimization (ACO), genetic algorithm (GA), and particle swarm optimization (PSO) and comparing their accuracy. A total number of 53 flood locations areas were identified, 35 locations of which were randomly selected in order to model flood susceptibility and the remaining 16 locations were used to validate the models. Learning vector quantization (LVQ), as one of the supervised neural network methods, was employed in order to estimate factors' importance. Nine flood conditioning factors namely: slope degree, plan curvature, altitude, topographic wetness index (TWI), stream power index (SPI), distance from river, land use/land cover, rainfall, and lithology were selected and the corresponding maps were prepared in ArcGIS. The frequency ratio (FR) model was used to assign weights to each class within particular controlling factor, then the weights was transferred into MATLAB software for further analyses and to combine with metaheuristic models. The ANFIS-PSO was found to be the most practical model in term of producing the highly focused flood susceptibility map with lesser spatial distribution related to highly susceptible classes. The chi-square result attests the same, where the ANFIS-PSO had the highest spatial differentiation within flood susceptibility classes over the study area. The area under the curve (AUC) obtained from ROC curve indicated the accuracy of 91.4%, 91.8%, 92.6% and 94.5% for the respective models of FR, ANFIS-ACO, ANFIS-GA, and ANFIS-PSO ensembles. So, the ensemble of ANFIS-PSO was introduced as the

  2. Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system.

    Science.gov (United States)

    Buisman-Pijlman, Femke T A; Sumracki, Nicole M; Gordon, Jake J; Hull, Philip R; Carter, C Sue; Tops, Mattie

    2014-04-01

    Recent research shows that the effects of oxytocin are more diverse than initially thought and that in some cases oxytocin can directly influence the response to drugs and alcohol. Large individual differences in basal oxytocin levels and reactivity of the oxytocin system exist. This paper will review the literature to explore how individual differences in the oxytocin system arise and examine the hypothesis that this may mediate some of the individual differences in susceptibility to addiction and relapse. Differences in the oxytocin system can be based on individual factors, e.g. genetic variation especially in the oxytocin receptor, age or gender, or be the result of early environmental influences such as social experiences, stress or trauma. The paper addresses the factors that cause individual differences in the oxytocin system and the environmental factors that have been identified to induce long-term changes in the developing oxytocin system during different life phases. Individual differences in the oxytocin system can influence effects of drugs and alcohol directly or indirectly. The oxytocin system has bidirectional interactions with the stress-axis, autonomic nervous system, neurotransmitter systems (e.g. dopamine, serotonin and GABA/glutamate) and the immune system. These systems are all important, even vital, in different phases of addiction. It is suggested that early life adversity can change the development of the oxytocin system and the way it modulates other systems. This in turn could minimise the negative feedback loops that would normally exist. Individuals may show only minor differences in behaviour and function unless subsequent stressors or drug use challenges the system. It is postulated that at that time individual differences in oxytocin levels, reactivity of the system or interactions with other systems can influence general resilience, drug effects and the susceptibility to develop problematic drug and alcohol use. © 2013. Published

  3. Design and Development of a Relative Humidity and Room Temperature Measurement System with On Line Data Logging Feature for Monitoring the Fermentation Room of Tea Factory

    Directory of Open Access Journals (Sweden)

    Utpal SARMA

    2011-12-01

    Full Text Available The design and development of a Relative Humidity (RH and Room Temperature (RT monitoring system with on line data logging feature for monitoring fermentation room of a tea factory is presented in this paper. A capacitive RH sensor with on chip signal conditioner is taken as RH sensor and a temperature to digital converter (TDC is used for ambient temperature monitoring. An 8051 core microcontroller is the heart of the whole system which reads the digital equivalent of RH data with the help of a 12-bit Analog to Digital (A/D converter and synchronize TDC to get the ambient temperature. The online data logging is achieved with the help of RS-232C communication. Field performance is also studied by installing it in the fermentation room of a tea factory.

  4. Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus

    Directory of Open Access Journals (Sweden)

    Steve P. Crampton

    2014-09-01

    Full Text Available Systemic lupus erythematosus (SLE represents a challenging autoimmune disease from a clinical perspective because of its varied forms of presentation. Although broad-spectrum steroids remain the standard treatment for SLE, they have many side effects and only provide temporary relief from the symptoms of the disease. Thus, gaining a deeper understanding of the genetic traits and biological pathways that confer susceptibility to SLE will help in the design of more targeted and effective therapeutics. Both human genome-wide association studies (GWAS and investigations using a variety of mouse models of SLE have been valuable for the identification of the genes and pathways involved in pathogenesis. In this Review, we link human susceptibility genes for SLE with biological pathways characterized in mouse models of lupus, and discuss how the mechanistic insights gained could advance drug discovery for the disease.

  5. Evaluation of susceptibility of Mycobacterium bovis to antituberculous drugs by radiometric BACTEC 460TB system.

    Science.gov (United States)

    Cavirani, S; Fanti, F; Benecchi, M; Calderaro, A; Taddei, S; Arcangeletti, C; Medici, M C; Dettori, G; Chezzi, C

    2003-04-01

    Susceptibility of Mycobacterium bovis strains to antituberculous drugs (isoniazid and rifampin) was detected by radiometric BACTEC 460TB system. M.bovis strains were isolated from tissue samples showing tuberculous lesions collected at an abbattoir from cattle belonging to 47 tuberculosis outbreaks occurring in Northern Italy in 1995-1999. Forty-six out of 61 strains (75.4%) resulted susceptible to both isoniazid and rifampin. Thirteen strains (21.3%) were resistant to isoniazid only. No strains showed resistance to rifampin only. Two strains (3.3%) resulted resistant to both drugs, showing antituberculous multidrug-resistance. Given the compulsory eradication program of bovine tuberculosis by elimination of infected animals and the ban on antituberculous drug treatments in animals, detection of resistant M. bovis strains appears of great interest.

  6. Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosus

    Science.gov (United States)

    Crampton, Steve P.; Morawski, Peter A.; Bolland, Silvia

    2014-01-01

    Systemic lupus erythematosus (SLE) represents a challenging autoimmune disease from a clinical perspective because of its varied forms of presentation. Although broad-spectrum steroids remain the standard treatment for SLE, they have many side effects and only provide temporary relief from the symptoms of the disease. Thus, gaining a deeper understanding of the genetic traits and biological pathways that confer susceptibility to SLE will help in the design of more targeted and effective therapeutics. Both human genome-wide association studies (GWAS) and investigations using a variety of mouse models of SLE have been valuable for the identification of the genes and pathways involved in pathogenesis. In this Review, we link human susceptibility genes for SLE with biological pathways characterized in mouse models of lupus, and discuss how the mechanistic insights gained could advance drug discovery for the disease. PMID:25147296

  7. Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci.

    Science.gov (United States)

    Molineros, Julio E; Yang, Wanling; Zhou, Xu-Jie; Sun, Celi; Okada, Yukinori; Zhang, Huoru; Heng Chua, Kek; Lau, Yu-Lung; Kochi, Yuta; Suzuki, Akari; Yamamoto, Kazuhiko; Ma, Jianyang; Bang, So-Young; Lee, Hye-Soon; Kim, Kwangwoo; Bae, Sang-Cheol; Zhang, Hong; Shen, Nan; Looger, Loren L; Nath, Swapan K

    2017-03-15

    We recently identified ten novel SLE susceptibility loci in Asians and uncovered several additional suggestive loci requiring further validation. This study aimed to replicate five of these suggestive loci in a Han Chinese cohort from Hong Kong, followed by meta-analysis (11,656 cases and 23,968 controls) on previously reported Asian and European populations, and to perform bioinformatic analyses on all 82 reported SLE loci to identify shared regulatory signatures. We performed a battery of analyses for these five loci, as well as joint analyses on all 82 SLE loci. All five loci passed genome-wide significance: MYNN (rs10936599, Pmeta = 1.92 × 10-13, OR = 1.14), ATG16L2 (rs11235604, Pmeta = 8.87 × 10 -12, OR = 0.78), CCL22 (rs223881, Pmeta = 5.87 × 10-16, OR = 0.87), ANKS1A (rs2762340, Pmeta = 4.93 × 10-15, OR = 0.87) and RNASEH2C (rs1308020, Pmeta = 2.96 × 10-19, OR = 0.84) and co-located with annotated gene regulatory elements. The novel loci share genetic signatures with other reported SLE loci, including effects on gene expression, transcription factor binding, and epigenetic characteristics. Most (56%) of the correlated (r2 > 0.8) SNPs from the 82 SLE loci were implicated in differential expression (9.81 × 10-198 SLE loci, consistent with apoptosis playing a critical role in SLE. Enrichment analysis revealed common pathways, gene ontology, protein domains, and cell type-specific expression. In summary, we provide evidence of five novel SLE susceptibility loci. Integrated bioinformatics using all 82 loci revealed that SLE susceptibility loci share many gene regulatory features, suggestive of conserved mechanisms of SLE etiopathogenesis. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  8. Drug susceptibility testing of M. tuberculosis with the help of test system of Sensititre MycoTB TREK Diagnostics

    Directory of Open Access Journals (Sweden)

    M. V. Makarova

    2015-01-01

    Full Text Available The article presents efficiency comparison of Sensititre test system and culture methods of Bactec 960 and Lowenstein-Jensen medium for drug susceptibility testing of tuberculosis mycobacteria.Cultures of M. tuberculosis of 137 patients have been studied. It has been found out that the part of coinciding results is fairly big for drug susceptibility testing by test system of Sensititre MycoTB and other methods. This system has the advantages related to standard procedures and capacity of drug susceptibility testing (degree to 12 drugs simultaneously within a short period of time (7-14 days. Drug susceptibility testing of M. tuberculosis by testing system of Sensititre MycoTB is simpler from technical point of view compared to all other systems. Sensititre MycoTB has been tested abroad and in MSPCT and certified and it can be used for the clinical practice. 

  9. Verification of respiratory-gated radiotherapy with new real-time tumour-tracking radiotherapy system using cine EPID images and a log file

    Science.gov (United States)

    Shiinoki, Takehiro; Hanazawa, Hideki; Yuasa, Yuki; Fujimoto, Koya; Uehara, Takuya; Shibuya, Keiko

    2017-02-01

    A combined system comprising the TrueBeam linear accelerator and a new real-time tumour-tracking radiotherapy system, SyncTraX, was installed at our institution. The objectives of this study are to develop a method for the verification of respiratory-gated radiotherapy with SyncTraX using cine electronic portal image device (EPID) images and a log file and to verify this treatment in clinical cases. Respiratory-gated radiotherapy was performed using TrueBeam and the SyncTraX system. Cine EPID images and a log file were acquired for a phantom and three patients during the course of the treatment. Digitally reconstructed radiographs (DRRs) were created for each treatment beam using a planning CT set. The cine EPID images, log file, and DRRs were analysed using a developed software. For the phantom case, the accuracy of the proposed method was evaluated to verify the respiratory-gated radiotherapy. For the clinical cases, the intra- and inter-fractional variations of the fiducial marker used as an internal surrogate were calculated to evaluate the gating accuracy and set-up uncertainty in the superior-inferior (SI), anterior-posterior (AP), and left-right (LR) directions. The proposed method achieved high accuracy for the phantom verification. For the clinical cases, the intra- and inter-fractional variations of the fiducial marker were  ⩽3 mm and  ±3 mm in the SI, AP, and LR directions. We proposed a method for the verification of respiratory-gated radiotherapy with SyncTraX using cine EPID images and a log file and showed that this treatment is performed with high accuracy in clinical cases. This work was partly presented at the 58th Annual meeting of American Association of Physicists in Medicine.

  10. Verification of respiratory-gated radiotherapy with new real-time tumour-tracking radiotherapy system using cine EPID images and a log file.

    Science.gov (United States)

    Shiinoki, Takehiro; Hanazawa, Hideki; Yuasa, Yuki; Fujimoto, Koya; Uehara, Takuya; Shibuya, Keiko

    2017-02-21

    A combined system comprising the TrueBeam linear accelerator and a new real-time tumour-tracking radiotherapy system, SyncTraX, was installed at our institution. The objectives of this study are to develop a method for the verification of respiratory-gated radiotherapy with SyncTraX using cine electronic portal image device (EPID) images and a log file and to verify this treatment in clinical cases. Respiratory-gated radiotherapy was performed using TrueBeam and the SyncTraX system. Cine EPID images and a log file were acquired for a phantom and three patients during the course of the treatment. Digitally reconstructed radiographs (DRRs) were created for each treatment beam using a planning CT set. The cine EPID images, log file, and DRRs were analysed using a developed software. For the phantom case, the accuracy of the proposed method was evaluated to verify the respiratory-gated radiotherapy. For the clinical cases, the intra- and inter-fractional variations of the fiducial marker used as an internal surrogate were calculated to evaluate the gating accuracy and set-up uncertainty in the superior-inferior (SI), anterior-posterior (AP), and left-right (LR) directions. The proposed method achieved high accuracy for the phantom verification. For the clinical cases, the intra- and inter-fractional variations of the fiducial marker were  ⩽3 mm and  ±3 mm in the SI, AP, and LR directions. We proposed a method for the verification of respiratory-gated radiotherapy with SyncTraX using cine EPID images and a log file and showed that this treatment is performed with high accuracy in clinical cases.

  11. Decision support using anesthesia information management system records and accreditation council for graduate medical education case logs for resident operating room assignments.

    Science.gov (United States)

    Wanderer, Jonathan P; Charnin, Jonathan; Driscoll, William D; Bailin, Michael T; Baker, Keith

    2013-08-01

    Our goal in this study was to develop decision support systems for resident operating room (OR) assignments using anesthesia information management system (AIMS) records and Accreditation Council for Graduate Medical Education (ACGME) case logs and evaluate the implementations. We developed 2 Web-based systems: an ACGME case-log visualization tool, and Residents Helping in Navigating OR Scheduling (Rhinos), an interactive system that solicits OR assignment requests from residents and creates resident profiles. Resident profiles are snapshots of the cases and procedures each resident has done and were derived from AIMS records and ACGME case logs. A Rhinos pilot was performed for 6 weeks on 2 clinical services. One hundred sixty-five requests were entered and used in OR assignment decisions by a single attending anesthesiologist. Each request consisted of a rank ordered list of up to 3 ORs. Residents had access to detailed information about these cases including surgeon and patient name, age, procedure type, and admission status. Success rates at matching resident requests were determined by comparing requests with AIMS records. Of the 165 requests, 87 first-choice matches (52.7%), 27 second-choice matches (16.4%), and 8 third-choice matches (4.8%) were made. Forty-three requests were unmatched (26.1%). Thirty-nine first-choice requests overlapped (23.6%). Full implementation followed on 8 clinical services for 8 weeks. Seven hundred fifty-four requests were reviewed by 15 attending anesthesiologists, with 339 first-choice matches (45.0%), 122 second-choice matches (16.2%), 55 third-choice matches (7.3%), and 238 unmatched (31.5%). There were 279 overlapping first-choice requests (37.0%). The overall combined match success rate was 69.4%. Separately, we developed an ACGME case-log visualization tool that allows individual resident experiences to be compared against case minimums as well as resident peer groups. We conclude that it is feasible to use ACGME case-log

  12. Technical basis for acceptance criteria on the susceptibility of digital systems to electromagnetic interference

    Energy Technology Data Exchange (ETDEWEB)

    Ewing, P.D.; Korsah, K. [Oak Ridge National Lab., TN (US); Antonescu, C. [Nuclear Regulatory Commission, Rockville, MD (US). Office of Nuclear Regulatory Research

    1992-12-31

    This paper discusses the development of the technical basis for establishing acceptance criteria on the susceptibility of digital systems to electromagnetic interference (EMI). The effort is sponsored by the US Nuclear Regulatory Commission and stems from the safety-related issues that need to be addressed with the application of digital instrumentation and controls systems in nuclear power plants. Designers of digital circuits are incorporating increasingly higher clock frequencies and lower logic voltage levels, thereby leading to the risk of susceptibility when spurious interference is misinterpreted as legitimate logic. Development of the technical basis for acceptance criteria centers around establishing good engineering practices to ensure that sufficient levels of electromagnetic compatibility (EMC) are maintained between the nuclear power plant`s electronic and electromechanical systems. First, good EMC design and installation practices are needed to control the emissions from interference sources and their impact on other nearby circuits and systems. Then, a test and evaluation program is needed to outline the EMI tests to be performed, the associated test methods to be followed, and adequate test limits to ensure that the circuit or system under test meets the recommended guidelines. Test and evaluation should be followed by periodic maintenance to assess whether the recommended EMI control practices continue to be adhered to as part of the routine operation of the nuclear power plant. By following these steps, the probability of encountering safety-related problems associated with EMI will be greatly reduced.

  13. Wounding induces local resistance but systemic susceptibility to Botrytis cinerea in pepper plants.

    Science.gov (United States)

    García, Tania; Gutiérrez, Jorge; Veloso, Javier; Gago-Fuentes, Raquel; Díaz, José

    2015-03-15

    Cotyledon wounding in pepper caused the early generation of hydrogen peroxide both locally (cotyledons) and systemically (upper true leaves). However, 72 h later there is a different wound response between local and systemic organs, as shown by resistance to the pathogenic fungus Botrytis cinerea, that increased locally and decreased systemically. Signaling by ethylene and jasmonic acid was assessed by using two inhibitors: 1-methylcyclopropene (MCP, inhibitor of ethylene receptors) and ibuprofen (inhibitor of jasmonate biosynthesis). MCP did not affect the modulation of resistance levels to Botrytis by wounding, ruling out the involvement of ethylene signaling. Ibuprofen did not inhibit wound-induced resistance at the local level, but inhibited wound-induced systemic susceptibility. Moreover, changes of biochemical and structural defenses in response to wounding were studied. Peroxidase activity and the expression of a peroxidase gene (CAPO1) increased locally as a response to wounding, but no changes were observed systemically. Lignin deposition was induced in wounded cotyledons, but was repressed in systemic leaves of wounded plants, whereas soluble phenolics did not change locally and decreased systemically. The expression of two other genes involved in plant defense (CABPR1 and CASC1) was also differentially regulated locally and systemically, pointing to a generalized increase in plant defenses at the local level and a systemic decrease as a response to wounding. Wound-induced defenses at the local level coincided with resistance to the necrotroph fungus B. cinerea, whereas depleted defenses in systemic leaves of wounded plants correlated to induced susceptibility against this pathogen. It may be that the local response acts as a sink of energy resources to mount a defense against pathogens, whereas in systemic organs the resources for defense are lower. Copyright © 2015 Elsevier GmbH. All rights reserved.

  14. New method for rapid Susceptibility Testing on blood culture with HB&L system: preliminary data

    Directory of Open Access Journals (Sweden)

    Vincenzo Rondinelli

    2010-12-01

    Full Text Available Blood culture, although represents the gold standard in detecting the ethiological agent of sepsis, is rather rarely required in relation to the real diagnostic importance. The result of this test depends in fact on many factors (sample volume, time of collection, accuracy, antibiotic therapy, contamination, number of drawings, drawing site, interpretation difficulties, etc. that are often considered by many clinicians so limited as to doubt about their actual value. The disadvantages are therefore represented by the lack of standardization but also by the low sensitivity and above all by the technical times too long for the clinical needs. Blood culture begins with the drawing of samples from the “septic” patient followed incubation of the bottles in automatic thermostated systems. In case of positive result (36 hours, the culture is Gram stained and streaked on solid media in order to obtain isolated colonies for the identification and the susceptibility testing (48 hours from positive result. The long time required for pathogen identification and susceptibility testing involves empirical broad spectrum antibiotic therapy that can promote the increase of bacterial resistance but also patient management costs. A clinically useful report should be available on short notice in order to guide the clinician to choose the most appropriate antibiotic. The microbiologist has therefore the hard work of reviewing the organization and the management of the procedures.We have therefore started to consider the possibility of treating the blood as an biological liquid in order to quickly determine the susceptibility of bacteria to antibiotics.

  15. Comparison of the VITEK 2 antifungal susceptibility system with Etest using clinical isolates of Candida species.

    Science.gov (United States)

    Alfouzan, Wadha; Al-Enezi, Tahani; AlRoomi, Ebteehal; Sandhya, Vayalil; Chandy, Rachel; Khan, Zia Uddin

    Candida species are part of the normal human microbiota. However, in recent years, nosocomial bloodstream Candida infections have emerged as a significant problem ranking the fourth common cause of fungemia in intensive care units. Although microdilution methods are the ones recommended for susceptibility testing, they are difficult to undertake in the clinical practice. Thus, an automated commercially available test is ideal. To compare minimum inhibitory concentrations (MICs) obtained with the recently introduced Vitek 2 yeast susceptibility system card (AST-YS01) with Etest. 263 clinical Candida isolates representing six species were included in the study. Categorical agreements (CA) were assessed as described elsewhere. Irrespective of the Candida species tested, the overall CA between Vitek 2 and Etest ranged between 66.7% and 100%. In general, Etest yielded lower MICs than Vitek 2. For Candida albicans, the CA between Vitek 2 and Etest was >95% for amphotericin B, voriconazole and flucytosine, but only 89% for fluconazole. With respect to Candida glabrata, the CA was between 97% and 100%. The major errors were with Candida krusei and flucytosine and Candida kefyr and amphotericin B. Candida tropicalis susceptibility for fluconazole by Vitek 2 reported more SDD and resistant strains than Etest. Candida parapsilosis showed 100% CA against all the four antifungals tested. No very major errors were detected between the two methods. Vitek 2 provided comparable results to Etest with quick turnaround for the testing of Candida species susceptibilities. Copyright © 2017 Asociación Española de Micología. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Evaluation of automated systems for aminoglycosides and fluoroquinolones susceptibility testing for Carbapenem-resistant Enterobacteriaceae

    Directory of Open Access Journals (Sweden)

    Zhichang Zhao

    2017-08-01

    Full Text Available Abstract Background Automated systems (MicroScan WalkAway 96 Plus, Phoenix 100, and Vitek 2 Compact are widely used in clinical laboratories nowadays. The aim of this study is to evaluate the performance of these three systems for susceptibility testing of aminoglycosides and fluoroquinolones against Carbapenem-resistant Enterobacteriaceae (CRE. Methods A total of 75 CRE isolates were used in this study. Quinolone resistance determinants (QRDs (qnrA, qnrB, qnrC, qnrD, qnrS, aac(6′-Ib-cr, oqxAB and qepA and aminoglycoside resistance determinants (ARDs (aac(6′-Ib, armA, npmA, rmtA, rmtB, rmtC, rmtD and rmtE of these CRE were screened by PCR. The MICs of aminoglycosides (gentamicin and amikacin and fluoroquinolones (ciprofloxacin and levofloxacin to CRE obtained with the automated systems were compared with the reference method (agar dilution method. Results Totally, 97.3% (73/75 of CRE harbored QRDs. The qnr gene was the most common QRD determinant identified in 68 (96.7%, followed by aac (6′-Ib-cr in 56 (74.7%, oqxAB in 23 (30.7%, and qepA in 2 (2.7%, respectively. 22.7% (17/75 of CRE harbored ARD determinants. rmtA, rmtB and npmA were identified among these isolates in 6 (8.0%, 6 (8.0% and 5 (6.7%, respectively. A total of 900 results were obtained in this study. Overall, the total error rate was 9.89%. Twenty-eight very major errors (3.11%, 22 major errors (2.44% and 39 minor errors (4.33% were identified against agar dilution method. The very major errors were almost evenly distributed between results for fluoroquinolones (2.89% and aminoglycosides (3.33%, while the major errors and minor errors were more commonly found in the results of fluoroquinolones (3.11% and 6.44%, respectively than aminoglycosides (1.78% and 2.22%, respectively. Conclusions Our study shows that testing difficulties in susceptibility testing do exist in automated systems. We suggest clinical laboratories using automated systems should consider using a second

  17. WELLOG: computer software system for analyzing and plotting well log data (a user's guide to WELLOG. REV2)

    Energy Technology Data Exchange (ETDEWEB)

    Atwood, J.W.; Killpack, T.J.; Glenn, W.E.; Nutter, C.

    1980-11-01

    WELLOG is a software system that has been developed to plot digitized well log data in a manner suitable for analysis. Multiple logs can be plotted side by side for correlation analysis, and up to three logs can be plotted on a cross plot. Data entry, editing, and modification functions are also provided by the program. Digitizing is accomplished by a TEKTRONIX 4954 (on-line) digitizing tablet, and plotting is done on a TEKTRONIX 4014 graphics terminal, a STATOS 42 electrostatic plotter, or a CALCOMP pen plotter using a device independent plotting system. This program (WELLOG.REV2) is not as system-dependent as the former version (WELLOG.REV1). The user must supply a program to digitize the data and supply subroutines to interface the program with file manipulation and plotting routines of their system. One major improvement is the use of an on-line digitizing system whereby the program accesses disk files rather than reading the data from tape. In REV2 the merge file has been automated such that the file is initialized automatically upon creation and also delete protected. The randomly spaced data capabilities have been greatly improved allowing the averaging and cross plotting of the data. Routines have been added which allow all of the cross plots excepting the Z-plot to be printed on a line printer. Dresser Atlas' A-K plot has also been added. The program is almost completely self-contained needing only a few interfacing and system subroutines.

  18. Statistical and spatial analysis of landslide susceptibility maps with different classification systems

    OpenAIRE

    Baeza, Cristina; Lantada Zarzosa, Maria de Las Nieves; Amorim, Samuel

    2016-01-01

    The final publication is available at Springer via http://dx.doi.org/10.1007/s12665-016-6124-1 A landslide susceptibility map is an essential tool for land-use spatial planning and management in mountain areas. However, a classification system used for readability determines the final appearance of the map and may therefore influence the decision-making tasks adopted. The present paper addresses the spatial comparison and the accuracy assessment of some well-known classification methods ap...

  19. Assessment of antibiotic susceptibility of Legionella pneumophila isolated from water systems in Poland.

    Science.gov (United States)

    Sikora, Agnieszka; Gładysz, Iwona; Kozioł-Montewka, Maria; Wójtowicz-Bobin, Małgorzata; Stańczak, Tomasz; Matuszewska, Renata; Krogulska, Bożena

    2017-03-21

    Several studies have reported therapy failures in patients with legionnaires'disease; however, antimicrobial resistance of clinical and environmental isolates of Legionella spp. has not yet been documented. Routine susceptibility testing of Legionella spp. is not recommended because of difficulties in determining standard minimal inhibitory concentration values. The purpose of this study was to analyze the antimicrobial susceptibility of Legionella pneumophila. strains isolated from a water supply system. Twenty-eight isolates of L. pneumophila (16 - L. pneumophila SG 1, 12 - L. pneumophila SG 2-14) obtained from water systems in public buildings in Poland were tested. Susceptibility testing was performed using the E-test method. The tested antibiotic were azithromycin, ciprofloxacin, and rifampicin. The medium used for the susceptibility testing was BCYE-, a special medium for Legionella cultivation. Among the tested strains, L. pneumophila was the only one resistant to azithromycin. It was a strain of L. pneumophila SG 2-14 isolated from the water system in a sanitorium. All isolates were found to be sensitive to ciprofloxacin and rifampicin. However, the azithromycin-resistant strain exhibited higher ciprofloxacin and rifampicin MIC (1.5 μg/ml, and 0.19 μg/ml, respectively). The MIC50 for azithromycin, ciprofloxacin, and rifampicin were 0,032, 0,125, and 0,003 μg/ml, respectively. The MIC90 for azithromycin, ciprofloxacin, and rifampicin were 0,032, 0,125, and 0,003 μg/ml, respectively. Azithromycin resistance was found in one strain of L. pneumophila SG 2-14, but the resistance mechanism is unknown and needs further study. It is possible that therapeutic failures in Legionnaires' disease may be associated with bacterial resistance which should be taken into account. The antibiotic sensitivity testing described in this study could be helpful in detecting the resistance of clinical L. pneumophila isolates. Ciprofloxacin and rifampicin have good in vitro

  20. Power to the logs!

    CERN Multimedia

    CERN. Geneva; MACMAHON, Joseph

    2015-01-01

    Are you tired of using grep, vi and emacs to read your logs? Do you feel like you’re missing the big picture? Does the word "statistics" put a smile on your face? Then it’s time to give power to the logs!

  1. An integrated mass wasting susceptibility assesment by geographical information systems and remote sensing applications: Example from North Turkey

    Science.gov (United States)

    Akgün, Aykut

    2016-04-01

    The Northern part of Turkey have been suffering from both landslides and snow avalanches due to the steep topography and climatological characteristics triggering the processes. In order to manage these natural hazard phenomenons, regional hazards assessments are both crucial and essential for the region. In this context, an integrated hazard assesment including landslide and snow avalanche was carried out for a selected area at North Turkey. Caykara (Trabzon) district was one of the most suitable areas for such a purpose, because several landslide and snow avalanche cases occured in the area during the last two decades. To inspect the landslide and snow avalanche susceptibility of the area, geographical information systems and remote sensing based assessments were applied to the area. To produce a landslide susceptibility map, logistic regression model was used by using lithological, topographical and environmental data set. To obtain a snow avalanche susceptibility map, topograhical data such as slope gradient, slope aspect and slope curvature, environmental data such as normaliazed vegetation index (NDVI), snow accumlation areas and landcover were taken into account, and these data set were analyzed by a 2D modelling tool, called as CONEFALL. By obtaining the landslide and snow avalanche susceptibility maps, five susceptibility classes from very low to very high were differentiated in the area. The both susceptibility maps were also verified by the actual field data as well, and it was determined that the obtained maps were successful. Then, the both susceptibility maps were overlaid, and finally an integrated mass wasting susceptibility map was created. In this final map, total susceptible areas to both landslide and snow avalanche occurrence were determined. The final susceptibility map is believed and expected to be used by the govermental and local authorities as a decision makers to mitigate the landslide and snow avalanche based hazards in the area.

  2. A method of mapping sinkhole susceptibility using a geographic information system : a case study for interstates in the karst counties of Virginia.

    Science.gov (United States)

    2015-02-01

    This study proposes the use of a geographic information system (GIS) to create a susceptibility map, pinpointing : regions in the karst counties of Virginia, in particular, along interstates, most susceptible to future sinkhole : development, determi...

  3. Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE.

    Directory of Open Access Journals (Sweden)

    Anna Hellquist

    Full Text Available BACKGROUND: Systemic lupus erythematosus (SLE is a complex autoimmune disorder with multiple susceptibility genes. We have previously reported suggestive linkage to the chromosomal region 14q21-q23 in Finnish SLE families. PRINCIPAL FINDINGS: Genetic fine mapping of this region in the same family material, together with a large collection of parent affected trios from UK and two independent case-control cohorts from Finland and Sweden, indicated that a novel uncharacterized gene, MAMDC1 (MAM domain containing glycosylphosphatidylinositol anchor 2, also known as MDGA2, MIM 611128, represents a putative susceptibility gene for SLE. In a combined analysis of the whole dataset, significant evidence of association was detected for the MAMDC1 intronic single nucleotide polymorphisms (SNP rs961616 (P -value = 0.001, Odds Ratio (OR = 1.292, 95% CI 1.103-1.513 and rs2297926 (P -value = 0.003, OR = 1.349, 95% CI 1.109-1.640. By Northern blot, real-time PCR (qRT-PCR and immunohistochemical (IHC analyses, we show that MAMDC1 is expressed in several tissues and cell types, and that the corresponding mRNA is up-regulated by the pro-inflammatory cytokines tumour necrosis factor alpha (TNF-alpha and interferon gamma (IFN-gamma in THP-1 monocytes. Based on its homology to known proteins with similar structure, MAMDC1 appears to be a novel member of the adhesion molecules of the immunoglobulin superfamily (IgCAM, which is involved in cell adhesion, migration, and recruitment to inflammatory sites. Remarkably, some IgCAMs have been shown to interact with ITGAM, the product of another SLE susceptibility gene recently discovered in two independent genome wide association (GWA scans. SIGNIFICANCE: Further studies focused on MAMDC1 and other molecules involved in these pathways might thus provide new insight into the pathogenesis of SLE.

  4. Drug susceptibility testing of clinical isolates of streptococci and enterococci by the Phoenix automated microbiology system

    Directory of Open Access Journals (Sweden)

    Sokeng Gertrude

    2007-05-01

    Full Text Available Abstract Background Drug resistance is an emerging problem among streptococcal and enterococcal species. Automated diagnostic systems for species identification and antimicrobial susceptibility testing (AST have become recently available. We evaluated drug susceptibility of clinical isolates of streptococci and enterococci using the recent Phoenix system (BD, Sparks, MD. Diagnostic tools included the new SMIC/ID-2 panel for streptococci, and the PMIC/ID-14 for enterococci. Two-hundred and fifty isolates have been investigated: β-hemolytic streptococci (n = 65, Streptococcus pneumoniae (n = 50, viridans group streptococci (n = 32, Enterococcus faecium (n = 40, Enterococcus faecalis (n = 43, other catalase-negative cocci (n = 20. When needed, species ID was determined using molecular methods. Test bacterial strains were chosen among those carrying clinically-relevant resistance determinants (penicillin, macrolides, fluoroquinolones, glycopeptides. AST results of the Phoenix system were compared to minimal inhibitory concentration (MIC values measured by the Etest method (AB Biodisk, Solna, Sweden. Results Streptococci: essential agreement (EA and categorical agreement (CA were 91.9% and 98.8%, respectively. Major (ME and minor errors (mE accounted for 0.1% and 1.1% of isolates, respectively. No very major errors (VME were produced. Enterococci: EA was 97%, CA 96%. Small numbers of VME (0.9%, ME (1.4% and mE (2.8% were obtained. Overall, EA and CA rates for most drugs were above 90% for both genera. A few VME were found: a teicoplanin and high-level streptomycin for E. faecalis, b high-level gentamicin for E. faecium. The mean time to results (± SD was 11.8 ± 0.9 h, with minor differences between streptococci and enterococci. Conclusion The Phoenix system emerged as an effective tool for quantitative AST. Panels based on dilution tests provided rapid and accurate MIC values with regard to clinically-relevant streptococcal and enterococcal

  5. Mariners Weather Log

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Mariners Weather Log (MWL) is a publication containing articles, news and information about marine weather events and phenomena, worldwide environmental impact...

  6. Multicenter evaluation of fully automated BACTEC Mycobacteria Growth Indicator Tube 960 system for susceptibility testing of Mycobacterium tuberculosis.

    Science.gov (United States)

    Bemer, Pascale; Palicova, Frantiska; Rüsch-Gerdes, Sabine; Drugeon, Henri B; Pfyffer, Gaby E

    2002-01-01

    The reliability of the BACTEC Mycobacteria Growth Indicator Tube (MGIT) 960 system for testing of Mycobacterium tuberculosis susceptibility to the three front-line drugs (isoniazid [INH], rifampin [RIF], and ethambutol [EMB]) plus streptomycin (STR) was compared to that of the BACTEC 460 TB system. The proportion method was used to resolve discrepant results by an independent arbiter. One hundred and ten strains were tested with an overall agreement of 93.5%. Discrepant results were obtained for seven strains (6.4%) with INH (resistant by BACTEC MGIT 960; susceptible by BACTEC 460 TB), for one strain (0.9%) with RIF (resistant by BACTEC MGIT 960; susceptible by BACTEC 460 TB), for seven strains (6.4%) with EMB (six resistant by BACTEC MGIT 960 and susceptible by BACTEC 460 TB; one susceptible by BACTEC MGIT 960 and resistant by BACTEC 460 TB), and for 19 strains (17.3%) with STR (resistant by BACTEC MGIT 960 and susceptible by BACTEC 460 TB). After resolution of discrepant results, the sensitivity of the BACTEC MGIT 960 system was 100% for all four drugs and specificity ranged from 89.8% for STR to 100% for RIF. Turnaround times were 4.6 to 11.7 days (median, 6.5 days) for BACTEC MGIT 960 and 4.0 to 10.0 days (median, 7.0 days) for BACTEC 460 TB. These data demonstrate that the fully automated and nonradiometric BACTEC MGIT 960 system is an accurate method for rapid susceptibility testing of M. tuberculosis.

  7. Bio-susceptibility of materials and thermal insulation systems used for historical buildings

    Science.gov (United States)

    Sterflinger, Katja; Ettenauer, Joerg; Pinar, Guadalupe

    2013-04-01

    In historical buildings of Northern countries high levels of energy are necessary to reach comfortable temperatures especially during the cold season. For this reason historical buildings are now also included in country specific regulations and ordinances to enhance the "energy - efficiency". Since an exterior insulation - as it is commonly used for modern architecture - is incompatible with monument protection, several indoor insulation systems based on historical and ecological materials, are on the market that should improve the thermic performance of a historical building. However, using organic materials as cellulose, loam, weed or wood, bears the risk of fungal growth and thus may lead to health problems in indoor environments. For this reason 5 different ecological indoor insulations systems were tested for their bio-susceptibility against various fungi both under natural conditions - after 2 years of installation in an historical building - and under laboratory conditions with high levels of relative humidity. Fungal growth was evaluated by classical isolation and cultivation as well as by molecular methods. The materials turned out to have a quite different susceptibility towards fungal contamination. Whereas insulations made of bloated Perlite (plaster and board) did not show any fungal growth after 2 years of exposition, the historical insulation made of loam and weed had high cell counts of various fungi. In laboratory experiments wooden softboard represented the best environment for fungal growth. As a result from this study, plaster and board made of bloated Perlite are presented as being the most appropriate materials for thermal insulation at least from the microbiological and hygienic point of view. For future investigations and for the monitoring of fungi in insulation and other building materials we suggest a molecular biology approach with a common protocol for quantitative DNA-extraction and amplification.

  8. Well logging for physical properties

    Energy Technology Data Exchange (ETDEWEB)

    Hearst, J.R.; Nelson, P.H.

    1985-01-01

    This book presents the fundamentals of well logging techniques for petroleum and natural gas deposits. Topics considered include the wellbore environment, logging practice; temperature, electrical and magnetic methods; nuclear radiation logging; acoustic logging; borehole gravimetry; ethology; porosity; saturation; permeability; fluid movement; fractures; elemental analysis; cement; directional surveying; dipmeter logging, and some other interesting applications.

  9. Reconsidering Data Logging in Light of Digital Forensics

    Science.gov (United States)

    Chou, Bin-Hui; Takahashi, Kenichi; Hori, Yoshiaki; Sakurai, Kouichi

    Logs record the events that have happened within in a system so they are considered the history of system activities. They are one of the objects that digital forensic investigators would like to examine when a security incident happens. However, logs were initially created for trouble shooting, and are not purposefully designed for digital forensics. Thus, enormous and redundant log data make analysis tasks complicated and time-consuming to find valuable information, and make logging-related techniques difficult utilized in some systems such as embedded systems. In this paper, we reconsider a data logging mechanism in terms of forensics and consequently, we propose purpose-based forensic logging. In purpose-based forensic logging, we only collect the required logs according to a specific purpose, which could decrease the space that logs occupy and may mitigate the analysis tasks during forensic investigations.

  10. Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study.

    Directory of Open Access Journals (Sweden)

    Elisa Alonso-Perez

    Full Text Available INTRODUCTION: Systemic Lupus Erythematosus (SLE shows a spectrum of clinical manifestations that complicate its diagnosis, treatment and research. This variability is likely related with environmental exposures and genetic factors among which known SLE susceptibility loci are prime candidates. The first published analyses seem to indicate that this is the case for some of them, but results are still inconclusive and we aimed to further explore this question. METHODS: European SLE patients, 1444, recruited at 17 centres from 10 countries were analyzed. Genotypes for 26 SLE associated SNPs were compared between patients with and without each of 11 clinical features: ten of the American College of Rheumatology (ACR classification criteria (except ANAs and age of disease onset. These analyses were adjusted for centre of recruitment, top ancestry informative markers, gender and time of follow-up. Overlap of samples with previous studies was excluded for assessing replication. RESULTS: THERE WERE THREE NEW ASSOCIATIONS: the SNPs in XKR6 and in FAM167A-BLK were associated with lupus nephritis (OR=0.76 and 1.30, P(corr =0.007 and 0.03, respectively and the SNP of MECP2, which is in chromosome X, with earlier age of disease onset in men. The previously reported association of STAT4 with early age of disease onset was replicated. Some other results were suggestive of the presence of additional associations. Together, the association signals provided support to some previous findings and to the characterization of lupus nephritis, autoantibodies and age of disease onset as the clinical features more associated with SLE loci. CONCLUSION: Some of the SLE loci shape the disease phenotype in addition to increase susceptibility to SLE. This influence is more prominent for some clinical features than for others. However, results are only partially consistent between studies and subphenotype specific GWAS are needed to unravel their genetic component.

  11. Further Evidence of Subphenotype Association with Systemic Lupus Erythematosus Susceptibility Loci: A European Cases Only Study

    Science.gov (United States)

    Alonso-Perez, Elisa; Suarez-Gestal, Marian; Calaza, Manuel; Ordi-Ros, Josep; Balada, Eva; Bijl, Marc; Papasteriades, Chryssa; Carreira, Patricia; Skopouli, Fotini N.; Witte, Torsten; Endreffy, Emöke; Marchini, Maurizio; Migliaresi, Sergio; Sebastiani, Gian Domenico; Santos, Maria Jose; Suarez, Ana; Blanco, Francisco J.; Barizzone, Nadia; Pullmann, Rudolf; Ruzickova, Sarka; Lauwerys, Bernard R.; Gomez-Reino, Juan J.; Gonzalez, Antonio

    2012-01-01

    Introduction Systemic Lupus Erythematosus (SLE) shows a spectrum of clinical manifestations that complicate its diagnosis, treatment and research. This variability is likely related with environmental exposures and genetic factors among which known SLE susceptibility loci are prime candidates. The first published analyses seem to indicate that this is the case for some of them, but results are still inconclusive and we aimed to further explore this question. Methods European SLE patients, 1444, recruited at 17 centres from 10 countries were analyzed. Genotypes for 26 SLE associated SNPs were compared between patients with and without each of 11 clinical features: ten of the American College of Rheumatology (ACR) classification criteria (except ANAs) and age of disease onset. These analyses were adjusted for centre of recruitment, top ancestry informative markers, gender and time of follow-up. Overlap of samples with previous studies was excluded for assessing replication. Results There were three new associations: the SNPs in XKR6 and in FAM167A-BLK were associated with lupus nephritis (OR = 0.76 and 1.30, Pcorr = 0.007 and 0.03, respectively) and the SNP of MECP2, which is in chromosome X, with earlier age of disease onset in men. The previously reported association of STAT4 with early age of disease onset was replicated. Some other results were suggestive of the presence of additional associations. Together, the association signals provided support to some previous findings and to the characterization of lupus nephritis, autoantibodies and age of disease onset as the clinical features more associated with SLE loci. Conclusion Some of the SLE loci shape the disease phenotype in addition to increase susceptibility to SLE. This influence is more prominent for some clinical features than for others. However, results are only partially consistent between studies and subphenotype specific GWAS are needed to unravel their genetic component. PMID:23049788

  12. Perceived Task-Difficulty Recognition from Log-File Information for the Use in Adaptive Intelligent Tutoring Systems

    Science.gov (United States)

    Janning, Ruth; Schatten, Carlotta; Schmidt-Thieme, Lars

    2016-01-01

    Recognising students' emotion, affect or cognition is a relatively young field and still a challenging task in the area of intelligent tutoring systems. There are several ways to use the output of these recognition tasks within the system. The approach most often mentioned in the literature is using it for giving feedback to the students. The…

  13. Log4J

    CERN Document Server

    Perry, Steven

    2009-01-01

    Log4j has been around for a while now, and it seems like so many applications use it. I've used it in my applications for years now, and I'll bet you have too. But every time I need to do something with log4j I've never done before I find myself searching for examples of how to do whatever that is, and I don't usually have much luck. I believe the reason for this is that there is a not a great deal of useful information about log4j, either in print or on the Internet. The information is too simple to be of real-world use, too complicated to be distilled quickly (which is what most developers

  14. NMR logging apparatus

    Science.gov (United States)

    Walsh, David O; Turner, Peter

    2014-05-27

    Technologies including NMR logging apparatus and methods are disclosed. Example NMR logging apparatus may include surface instrumentation and one or more downhole probes configured to fit within an earth borehole. The surface instrumentation may comprise a power amplifier, which may be coupled to the downhole probes via one or more transmission lines, and a controller configured to cause the power amplifier to generate a NMR activating pulse or sequence of pulses. Impedance matching means may be configured to match an output impedance of the power amplifier through a transmission line to a load impedance of a downhole probe. Methods may include deploying the various elements of disclosed NMR logging apparatus and using the apparatus to perform NMR measurements.

  15. You Are Not Logged In: Context and Interpersonal Meaning of Instructions and Links in a typical Learning Management System

    Directory of Open Access Journals (Sweden)

    Hakeem Olafemi Ogunmuyiwa

    2016-11-01

    Full Text Available It is common knowledge that the incorporation of Learning Management Systems (LMS in ESL/EFL instruction has enhanced learners understanding of the language just as it has helped teachers in monitoring students’ progress. However, the use of these eLearning platforms can be quite challenging for EFL learners who are yet to be proficient in the English language. This is because all course information and instructions are offered in the language. Following the notion of context and language metafunctions by Halliday (1985 and his followers, analysis of some linguistic expressions in typical learning management systems is conducted. I show how context and interpersonal meanings are established, and how they can enhance learners’ comprehension of information and instructions. The linguistic expressions used as data are sourced from student-specific pages of the web-based Learning Management System (Blackboard and the Modular Object-Oriented Dynamic Learning Environment (Moodle as adapted in colleges and institutes in Saudi Arabia.

  16. Pathogen-triggered ethylene signaling mediates systemic-induced susceptibility to herbivory in Arabidopsis.

    Science.gov (United States)

    Groen, Simon C; Whiteman, Noah K; Bahrami, Adam K; Wilczek, Amity M; Cui, Jianping; Russell, Jacob A; Cibrian-Jaramillo, Angelica; Butler, Ian A; Rana, Jignasha D; Huang, Guo-Hua; Bush, Jenifer; Ausubel, Frederick M; Pierce, Naomi E

    2013-11-01

    Multicellular eukaryotic organisms are attacked by numerous parasites from diverse phyla, often simultaneously or sequentially. An outstanding question in these interactions is how hosts integrate signals induced by the attack of different parasites. We used a model system comprised of the plant host Arabidopsis thaliana, the hemibiotrophic bacterial phytopathogen Pseudomonas syringae, and herbivorous larvae of the moth Trichoplusia ni (cabbage looper) to characterize mechanisms involved in systemic-induced susceptibility (SIS) to T. ni herbivory caused by prior infection by virulent P. syringae. We uncovered a complex multilayered induction mechanism for SIS to herbivory. In this mechanism, antiherbivore defenses that depend on signaling via (1) the jasmonic acid-isoleucine conjugate (JA-Ile) and (2) other octadecanoids are suppressed by microbe-associated molecular pattern-triggered salicylic acid (SA) signaling and infection-triggered ethylene signaling, respectively. SIS to herbivory is, in turn, counteracted by a combination of the bacterial JA-Ile mimic coronatine and type III virulence-associated effectors. Our results show that SIS to herbivory involves more than antagonistic signaling between SA and JA-Ile and provide insight into the unexpectedly complex mechanisms behind a seemingly simple trade-off in plant defense against multiple enemies.

  17. Evaluation of MGIT 960 System for the Second-Line Drugs Susceptibility Testing of Mycobacterium tuberculosis

    Directory of Open Access Journals (Sweden)

    Hyejin Kim

    2013-01-01

    Full Text Available Many laboratories validate DST of the second-line drugs by BACTEC MGIT 960 system. The objective of this study is to evaluate the critical concentration and perform DST for the 2nd line drugs. We evaluated 193 clinical strains of M. tuberculosis isolated from patients in South Korea. Testing the critical concentration of six second-line drugs was performed by MGIT 960 and compared with L-J proportion method. The critical concentration was determined to establish the most one that gave the difference between drug resistance and susceptibility in MGIT960 system. Good agreement of the following concentrations was found: Concordance was 95% for 0.5 μg/mL of moxifloxacin; 93.6%, 1.0 μg/mL of levofloxacin; 97.5%, 2.5 μg/mL of kanamycin; 90.6%, 2.5 μg/mL of capreomycin; 86.2%, 5.0 μg/mL of ethionamide; and 90.8%, 2.0 μg/mL of ρ-aminosalicylic acid. The critical concentrations of the four drugs, moxifloxacin, levofloxacin, kanamycin, and capreomycin, were concordant and reliable for testing 2nd line drug resistance. Further study of ethionamide and ρ-aminosalicylic acid is required.

  18. Modes of log gravity

    NARCIS (Netherlands)

    Bergshoeff, Eric A.; Hohm, Olaf; Rosseel, Jan; Townsend, Paul K.

    2011-01-01

    The physical modes of a recently proposed D-dimensional "critical gravity'', linearized about its anti-de Sitter vacuum, are investigated. All "log mode'' solutions, which we categorize as "spin-2'' or "Proca'', arise as limits of the massive spin-2 modes of the noncritical theory. The linearized

  19. Logging on to Learn

    Science.gov (United States)

    Butler, Kevin

    2010-01-01

    A classroom lecture at Capistrano Connections Academy in Southern California involves booting up the home computer, logging on to a Web site, and observing a teacher conducting a PowerPoint presentation of that day's lesson entirely online. Through microphone headsets, students can watch on their home computers, respond to the teacher's questions,…

  20. Susceptibility of Diabetic Rats to Pulmonary and Systemic Effects of Inhaled Photochemically-Aged Atmosphere and Ozone (O3)

    Science.gov (United States)

    Susceptibility of Diabetic Rats to Pulmonary and Systemic Effects of Inhaled Photochemically-Aged Atmosphere and Ozone (O3)MC Schladweiler1, SJ Snow2, QT Krantz1, C King1, JD Krug2, N Modak2, A Henriquez3, V Bass4, DJ Miller3, JE Richards1, EH Boykin1, R Jaskot1, MI Gilmour1 and ...

  1. Accelerating the HyperLogLog Cardinality Estimation Algorithm

    Directory of Open Access Journals (Sweden)

    Cem Bozkus

    2017-01-01

    Full Text Available In recent years, vast amounts of data of different kinds, from pictures and videos from our cameras to software logs from sensor networks and Internet routers operating day and night, are being generated. This has led to new big data problems, which require new algorithms to handle these large volumes of data and as a result are very computationally demanding because of the volumes to process. In this paper, we parallelize one of these new algorithms, namely, the HyperLogLog algorithm, which estimates the number of different items in a large data set with minimal memory usage, as it lowers the typical memory usage of this type of calculation from O(n to O(1. We have implemented parallelizations based on OpenMP and OpenCL and evaluated them in a standard multicore system, an Intel Xeon Phi, and two GPUs from different vendors. The results obtained in our experiments, in which we reach a speedup of 88.6 with respect to an optimized sequential implementation, are very positive, particularly taking into account the need to run this kind of algorithm on large amounts of data.

  2. LATTE - Log and Time Tracking for Elections

    Data.gov (United States)

    Office of Personnel Management — LATTE - Log and Time Tracking for Elections is a time tracking and voucher preparation system used to schedule employees to cover elections, to document their time...

  3. Infection risk in systemic lupus erythematosus patients: susceptibility factors and preventive strategies.

    Science.gov (United States)

    Danza, A; Ruiz-Irastorza, G

    2013-10-01

    Infection is one of the leading causes of morbidity and mortality in systemic lupus erythematosus (SLE). Bacterial infections are most frequent, followed by viral and fungal infections. The impaired cellular and humoral immune functions seen in patients with SLE are predisposing conditions, whilst disease activity, prednisone doses over 7.5-10 mg/day, high doses of methylprednisolone or cyclophosphamide are well-recognised risk factors for infection. The first six months after rituximab treatment and the use of more than three courses are also associated with an increased susceptibility for infection. It has not been established whether belimumab, azathioprine and mycophenolate mofetil increase the risk of serious infections. Most vaccines are effective and safe in SLE patients, although vaccination should be avoided during periods of active disease. Live virus vaccines are contraindicated for immunosuppressed patients. Influenza and pneumococcal vaccines are universally recommended. Tuberculosis prophylaxis should be considered in selected cases. Therefore, it is advisable not to exceed doses of 5 mg/day of prednisone in chronic treatment. Methylprednisolone and cyclophosphamide should be used in low-dose regimens. Antimalarials have a well-known protective role against infection, in addition to other beneficial properties, thus, hydroxychloroquine is recommended for all SLE patients where no contraindication exists.

  4. Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population

    Directory of Open Access Journals (Sweden)

    Aya Kawasaki

    2010-01-01

    Full Text Available Recent genome-wide association studies demonstrated association of single nucleotide polymorphisms (SNPs in the TNFAIP3 region at 6q23 with systemic lupus erythematosus (SLE in European-American populations. In this study, we investigated whether SNPs in the TNFAIP3 region are associated with SLE also in a Japanese population. A case-control association study was performed on the SNPs rs13192841, rs2230926, and rs6922466 in 318 Japanese SLE patients and 444 healthy controls. Association of rs2230926 G allele with SLE was replicated in Japanese (allelic association P=.033, odds ratio [OR] 1.47, recessive model P=.023, OR 8.52. The association was preferentially observed in the SLE patients with nephritis. When the TNFAIP3 mRNA levels of the HapMap samples were examined using GENEVAR database, the presence of TNFAIP3 rs2230926 G allele was associated with lower mRNA expression of TNFAIP3 (P=.013. These results indicated that TNFAIP3 is a susceptibility gene to SLE both in the Caucasian and Asian populations.

  5. A Low Cost/Low Power Open Source Sensor System for Automated Tuberculosis Drug Susceptibility Testing

    Directory of Open Access Journals (Sweden)

    Kyukwang Kim

    2016-06-01

    Full Text Available In this research an open source, low power sensor node was developed to check the growth of mycobacteria in a culture bottle with a nitrate reductase assay method for a drug susceptibility test. The sensor system reports the temperature and color sensor output frequency change of the culture bottle when the device is triggered. After the culture process is finished, a nitrite ion detecting solution based on a commercial nitrite ion detection kit is injected into the culture bottle by a syringe pump to check bacterial growth by the formation of a pigment by the reaction between the solution and the color sensor. Sensor status and NRA results are broadcasted via a Bluetooth low energy beacon. An Android application was developed to collect the broadcasted data, classify the status of cultured samples from multiple devices, and visualize the data for the end users, circumventing the need to examine each culture bottle manually during a long culture period. The authors expect that usage of the developed sensor will decrease the cost and required labor for handling large amounts of patient samples in local health centers in developing countries. All 3D-printerable hardware parts, a circuit diagram, and software are available online.

  6. A Low Cost/Low Power Open Source Sensor System for Automated Tuberculosis Drug Susceptibility Testing

    Science.gov (United States)

    Kim, Kyukwang; Kim, Hyeong Keun; Lim, Hwijoon; Myung, Hyun

    2016-01-01

    In this research an open source, low power sensor node was developed to check the growth of mycobacteria in a culture bottle with a nitrate reductase assay method for a drug susceptibility test. The sensor system reports the temperature and color sensor output frequency change of the culture bottle when the device is triggered. After the culture process is finished, a nitrite ion detecting solution based on a commercial nitrite ion detection kit is injected into the culture bottle by a syringe pump to check bacterial growth by the formation of a pigment by the reaction between the solution and the color sensor. Sensor status and NRA results are broadcasted via a Bluetooth low energy beacon. An Android application was developed to collect the broadcasted data, classify the status of cultured samples from multiple devices, and visualize the data for the end users, circumventing the need to examine each culture bottle manually during a long culture period. The authors expect that usage of the developed sensor will decrease the cost and required labor for handling large amounts of patient samples in local health centers in developing countries. All 3D-printerable hardware parts, a circuit diagram, and software are available online. PMID:27338406

  7. Family system characteristics and psychological adjustment to cancer susceptibility genetic testing: a prospective study.

    NARCIS (Netherlands)

    Oostrom, I.I.H. van; Meijers-Heijboer, H.; Duivenvoorden, H.J.; Brocker-Vriends, A.H.; Asperen, C.J. van; Sijmons, R.H.; Seynaeve, C.; Gool, A.R. van; Klijn, J.G.M.; Tibben, A.

    2007-01-01

    This study examined prospectively the contribution of family functioning, differentiation to parents, family communication and support from relatives to psychological distress in individuals undergoing genetic susceptibility testing for a known familial pathogenic BRCA1/2 or Hereditary nonpolyposis

  8. Family system characteristics and psychological adjustment to cancer susceptibility genetic testing : a prospective study

    NARCIS (Netherlands)

    van Oostrom, I.; Meijers-Heijboer, H.; Duivenvoorden, H. J.; Brocker-Vriends, A. H. J. T.; van Asperen, C. J.; Sijmons, R. H.; Seynaeve, C.; Van Gool, A. R.; Klijn, J. G. M.; Tibben, A.

    This study examined prospectively the contribution of family functioning, differentiation to parents, family communication and support from relatives to psychological distress in individuals undergoing genetic susceptibility testing for a known familial pathogenic BRCA1/2 or Hereditary nonpolyposis

  9. Hydrologic monitoring using open-source Arduino logging platforms in a socio-hydrological system of the drought-prone tropics, Guanacaste, Costa Rica

    Science.gov (United States)

    Hund, S. V.; Johnson, M. S.; Steyn, D. G.; Keddie, T.; Morillas, L.

    2015-12-01

    Water supply is highly disputed in the tropics of northwestern Costa Rica where rainfall exhibits high seasonal variability and long annual dry seasons. Water shortages are common during the dry season, and water conflicts emerge between domestic water users, intensively irrigated agriculture, the tourism industry, and ecological flows. Climate change may further increase the variability of precipitation and the risk for droughts, and pose challenges for small rural agricultural communities experiencing water stress. To adapt to seasonal droughts and improve resilience of communities to future changes, it is essential to increase understanding of interactions between components of the coupled hydrological-social system. Yet, hydrological monitoring and data on water use within developing countries of the humid tropics is limited. To address these challenges and contribute to extended monitoring networks, low-cost and open-source monitoring platforms were developed based off Arduino microelectronic boards and software and combined with hydrological sensors to monitor river stage and groundwater levels in two watersheds of Guanacaste, Costa Rica. Hydrologic monitoring stations are located in remote locations and powered by solar panels. Monitoring efforts were made possible through collaboration with local rural communities, and complemented with a mix of digitized water extraction data and community water use narratives to increase understanding of water use and challenges. We will present the development of the Arduino logging system, results of water supply in relation to water use for both the wet and dry season, and discuss these results within a socio-hydrological system context.

  10. Financial and Economic Analysis of Reduced Impact Logging

    Science.gov (United States)

    Tom Holmes

    2016-01-01

    Concern regarding extensive damage to tropical forests resulting from logging increased dramatically after World War II when mechanized logging systems developed in industrialized countries were deployed in the tropics. As a consequence, tropical foresters began developing logging procedures that were more environmentally benign, and by the 1990s, these practices began...

  11. Utilization and cost of log production from animal loging operations

    Science.gov (United States)

    Suraj P. Shrestha; Bobby L. Lanford; Robert B. Rummer; Mark Dubois

    2006-01-01

    Forest harvesting with animals is a labor-intensive operation. It is expensive to use machines on smaller woodlots, which require frequent moves if mechanically logged. So, small logging systems using animals may be more cost effective. In this study, work sampling was used for five animal logging operations in Alabama to measure productive and non-productive time...

  12. Susceptibility to antimicrobial agents and plasmid carrying in Aeromonas hydrophila isolated from two estuarine systems.

    Science.gov (United States)

    Montoya, R; Dominguez, M; Gonzalez, C; Mondaca, M A; Zemelman, R

    1992-01-01

    Susceptibility to various antimicrobial agents and the presence of plasmids was investigated in eleven strains of Aeromonas hydrophila isolated from samples of sea water and these strains isolated from Aulacomya ater. Transference of resistance to Escherichia coli was attempted by conjugation and transformation experiments. The strains showed multiple resistance toward beta-lactam antibiotics and susceptibility to other antimicrobial agents. Five strains harboured plasmids with molecular weights below 5.7 MD. It was not possible to relate the resistance of the strains with the presence of their plasmids.

  13. Remote wireless transmission and error recovery of log data

    Science.gov (United States)

    Zhao, Yipeng; Li, Ning; Wang, Caizhi

    2007-12-01

    Remote transmission of log data is an urgent problem for service companies. Remote transmission technology of log data here refers to both the transmission solution in combination with the CifNet multi-well data management system to automate the transmission, storage, management, and retrieval of log data to reduce turn-over time. It is an applied digital signature technology to implement breakpoint transmission and error recovery and ensure the effectiveness and reliability of log data transmission.

  14. Effects of systemic administration of sitafloxacin on subgingival microflora and antimicrobial susceptibility profile in acute periodontal lesions.

    Science.gov (United States)

    Tomita, Sachiyo; Kasai, Shunsuke; Ihara, Yuichiro; Imamura, Kentaro; Kita, Daichi; Ota, Koki; Kinumatsu, Takashi; Nakagawa, Taneaki; Saito, Atsushi

    2014-01-01

    The aim of this study was to assess the effect(s) of systemic administration of sitafloxacin on subgingival microbial profiles of acute periodontal lesions. Antimicrobial susceptibility of clinical isolates was also investigated. Patients with acute phases of chronic periodontitis were subjected to clinical examination and microbiological assessment of their subgingival plaque samples by culture technique. Sitafloxacin was then administered (100 mg/day for 5 days) systemically. The clinical and microbiological examinations were repeated 6-8 days after administration. Susceptibilities of clinical isolates to various antimicrobials were determined using the broth and agar dilution methods. From the sampled sites in 30 participants, a total of 355 clinical isolates (34 different bacterial species) were isolated and identified. Parvimonas micra, Prevotella intermedia and Streptococcus mitis were the most prevalent cultivable bacteria in acute sites. Systemic administration of sitafloxacin yielded a significant improvement in clinical and microbiological parameters. Among the antimicrobials tested, sitafloxacin was the most potent against the clinical isolates with an MIC90 of 0.12 μg/ml at baseline. After administration, most clinical isolates were still highly susceptible to sitafloxacin although some increase in MICs was observed. The results suggest that systemic administration of sitafloxacin is effective against subgingival bacteria isolated from acute periodontal lesions. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. SU-E-T-644: QuAArC: A 3D VMAT QA System Based On Radiochromic Film and Monte Carlo Simulation of Log Files

    Energy Technology Data Exchange (ETDEWEB)

    Barbeiro, A.R.; Ureba, A.; Baeza, J.A.; Jimenez-Ortega, E.; Plaza, A. Leal [Universidad de Sevilla, Departamento de Fisiologia Medica y Biofisica, Seville (Spain); Linares, R. [Hospital Infanta Luisa, Servicio de Radiofisica, Seville (Spain); Mateos, J.C.; Velazquez, S. [Hospital Universitario Virgen del Rocio, Servicio de Radiofisica, Seville (Spain)

    2015-06-15

    Purpose: VMAT involves two main sources of uncertainty: one related to the dose calculation accuracy, and the other linked to the continuous delivery of a discrete calculation. The purpose of this work is to present QuAArC, an alternative VMAT QA system to control and potentially reduce these uncertainties. Methods: An automated MC simulation of log files, recorded during VMAT treatment plans delivery, was implemented in order to simulate the actual treatment parameters. The linac head models and the phase-space data of each Control Point (CP) were simulated using the EGSnrc/BEAMnrc MC code, and the corresponding dose calculation was carried out by means of BEAMDOSE, a DOSXYZnrc code modification. A cylindrical phantom was specifically designed to host films rolled up at different radial distances from the isocenter, for a 3D and continuous dosimetric verification. It also allows axial and/or coronal films and point measurements with several types of ion chambers at different locations. Specific software was developed in MATLAB in order to process and evaluate the dosimetric measurements, which incorporates the analysis of dose distributions, profiles, dose difference maps, and 2D/3D gamma index. It is also possible to obtain the experimental DVH reconstructed on the patient CT, by an optimization method to find the individual contribution corresponding to each CP on the film, taking into account the total measured dose, and the corresponding CP dose calculated by MC. Results: The QuAArC system showed high reproducibility of measurements, and consistency with the results obtained with the commercial system implemented in the verification of the evaluated treatment plans. Conclusion: A VMAT QA system based on MC simulation and high resolution dosimetry with film has been developed for treatment verification. It shows to be useful for the study of the real VMAT capabilities, and also for linac commissioning and evaluation of other verification devices.

  16. Flood susceptibility mapping using novel ensembles of adaptive neuro fuzzy inference system and metaheuristic algorithms

    NARCIS (Netherlands)

    Razavi Termeh, Seyed Vahid; Kornejady, Aiding; Pourghasemi, Hamid Reza; Keesstra, Saskia

    2018-01-01

    Flood is one of the most destructive natural disasters which cause great financial and life losses per year. Therefore, producing susceptibility maps for flood management are necessary in order to reduce its harmful effects. The aim of the present study is to map flood hazard over the Jahrom

  17. Transcriptomics and systems biology analysis in identification of specific pathways involved in cacao resistance and susceptibility to witches' broom disease.

    Science.gov (United States)

    da Hora Junior, Braz Tavares; Poloni, Joice de Faria; Lopes, Maíza Alves; Dias, Cristiano Villela; Gramacho, Karina Peres; Schuster, Ivan; Sabau, Xavier; Cascardo, Júlio Cézar De Mattos; Mauro, Sônia Marli Zingaretti Di; Gesteira, Abelmon da Silva; Bonatto, Diego; Micheli, Fabienne

    2012-04-01

    This study reports on expression analysis associated with molecular systems biology of cacao-Moniliophthora perniciosa interaction. Gene expression data were obtained for two cacao genotypes (TSH1188, resistant; Catongo, susceptible) challenged or not with the fungus M. perniciosa and collected at three time points through disease. Using expression analysis, we identified 154 and 227 genes that are differentially expressed in TSH1188 and Catongo, respectively. The expression of some of these genes was confirmed by RT-qPCR. Physical protein-protein interaction (PPPI) networks of Arabidopsis thaliana orthologous proteins corresponding to resistant and susceptible interactions were obtained followed by cluster and gene ontology analyses. The integrated analysis of gene expression and systems biology allowed designing a general scheme of major mechanisms associated with witches' broom disease resistance/susceptibility. In this sense, the TSH1188 cultivar shows strong production of ROS and elicitors at the beginning of the interaction with M. perniciosa followed by resistance signal propagation and ROS detoxification. On the other hand, the Catongo genotype displays defense mechanisms that include the synthesis of some defense molecules but without success in regards to elimination of the fungus. This phase is followed by the activation of protein metabolism which is achieved with the production of proteasome associated with autophagy as a precursor mechanism of PCD. This work also identifies candidate genes for further functional studies and for genetic mapping and marker assisted selection.

  18. Dynamic Planar Convex Hull with Optimal Query Time and O(log n · log log n ) Update Time

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Jakob, Riko

    2000-01-01

    The dynamic maintenance of the convex hull of a set of points in the plane is one of the most important problems in computational geometry. We present a data structure supporting point insertions in amortized O(log n · log log log n) time, point deletions in amortized O(log n · log log n) time, a...

  19. Polarized dependence of nonlinear susceptibility in a single layer graphene system in infrared region

    Energy Technology Data Exchange (ETDEWEB)

    Solookinejad, G., E-mail: ghsolooki@gmail.com

    2016-09-15

    In this study, the linear and nonlinear susceptibility of a single-layer graphene nanostructure driven by a weak probe light and an elliptical polarized coupling field is discussed theoretically. The Landau levels of graphene can be separated in infrared or terahertz regions under the strong magnetic field. Therefore, by using the density matrix formalism in quantum optic, the linear and nonlinear susceptibility of the medium can be derived. It is demonstrated that by adjusting the elliptical parameter, one can manipulate the linear and nonlinear absorption as well as Kerr nonlinearity of the medium. It is realized that the enhanced Kerr nonlinearity can be possible with zero linear absorption and nonlinear amplification at some values of elliptical parameter. Our results may be having potential applications in quantum information science based on Nano scales devices.

  20. Querying Workflow Logs

    Directory of Open Access Journals (Sweden)

    Yan Tang

    2018-01-01

    Full Text Available A business process or workflow is an assembly of tasks that accomplishes a business goal. Business process management is the study of the design, configuration/implementation, enactment and monitoring, analysis, and re-design of workflows. The traditional methodology for the re-design and improvement of workflows relies on the well-known sequence of extract, transform, and load (ETL, data/process warehousing, and online analytical processing (OLAP tools. In this paper, we study the ad hoc queryiny of process enactments for (data-centric business processes, bypassing the traditional methodology for more flexibility in querying. We develop an algebraic query language based on “incident patterns” with four operators inspired from Business Process Model and Notation (BPMN representation, allowing the user to formulate ad hoc queries directly over workflow logs. A formal semantics of this query language, a preliminary query evaluation algorithm, and a group of elementary properties of the operators are provided.

  1. Analyzing Log Files using Data-Mining

    Directory of Open Access Journals (Sweden)

    Marius Mihut

    2008-01-01

    Full Text Available Information systems (i.e. servers, applications and communication devices create a large amount of monitoring data that are saved as log files. For analyzing them, a data-mining approach is helpful. This article presents the steps which are necessary for creating an ‘analyzing instrument’, based on an open source software called Waikato Environment for Knowledge Analysis (Weka [1]. For exemplification, a system log file created by a Windows-based operating system, is used as input file.

  2. [Alleles of the major histocompatibility system associated with susceptibility to the development of Takayasu's arteritis].

    Science.gov (United States)

    Flores-Domínguez, C; Hernández-Pacheco, G; Zúñiga, J; Gamboa, R; Granados, J; Reyes, P A; Vargas-Alarcón, Gilberto

    2002-01-01

    Since 1972, the relationship between HLA alleles and the susceptibility for Takayasu arteritis (TA) has been studied on different populations. Hence the results up to date are heterogeneous, the objective of the present review is to analyze the relationship between the presence of HLA alleles and the susceptibility for the development of TA considering the ethnic origin of the studied populations. We carried out a bibliographic review from clinical articles of case and controls studies on different populations on which the relationship between HLA alleles and the susceptibility for TA was studied, published since 1972 until February 2000. We reviewed articles of studies on Asian, Arab, North-American and Mexican Mestizo populations. On Asian populations TA was associated with HLA-A31, -B52, -B39, -B5 and -DR2, on Arabs with HLA-A2, -A9, -B35 and -DR7, on North-Americans with HLA-DR4 and on Mexican Mestizo with HLA-B5, -B52 and -DR6. On the other hand, recent reports establish that several HLA-B alleles (HLA-B52 and HLA-B39) associated with the disease share some residues important on the antigen presentation. Hence the heterogeneity of the results obtained up to date, it stands out the increase on HLA-B52 and HLA-DR4 reported on ethnically different populations. More recent data point the possible participation of an epitope located on the peptide-binding site of the HLA-B molecule (positions 63 and 67) that seems to be shared by several alleles associated with the disease. These residues might be participating on the presentation of an unknown antigen that would unchain the disease on the genetically susceptible individuals group.

  3. Ac susceptibility study of CaCl2 doped copper–zinc ferrite system

    Indian Academy of Sciences (India)

    Polycrystalline soft ferrites, Zn x Cu 1 – x Fe2O4 ( = 0.30, 0.50, 0.70, 0.80 and 0.90), doped with controlled amount of calcium chloride (CaCl2) were prepared by standard ceramic route and studied for a.c. susceptibility. X-ray diffraction studies of the compositions reveal formation of single-phase cubic spinel. The values of ...

  4. Relative susceptibility of stream macroinvertebrates to temephos and chlorpyrifos, determined in laboratory continuous-flow systems.

    Science.gov (United States)

    Muirhead-Thomson, R C

    1978-01-01

    Laboratory techniques are described for evaluating the lethal and behavioral impact of pesticides on a range of stream macroinvertebrates under continuous through-flow and simulated stream conditions. The same basic test unit has been used, with slight modifications, to study the reactions of both Simulium larvae and non-target stream invertebrates. On the basis of a standard 1-hr exposure period to different concentrations followed by a 24-hr holding period in a continuous flow of clean water, different test organisms showed wide and consistent differences in tolerance to each of the two insecticides tested. The widest difference between two organisms occurred in the case of the Amphipod, Gammarus pulex (LC90-95, greater than 1 ppm) which was found to be about 5000 x more tolerant to temephos than are nymphs of the mayfly, Baetis rhodani. (LC 90-95, 0.001-0.002 ppm) The widest difference in the reactions of any one species is shown on the part of Gammarus which is about 100 times more susceptible to chlorpyrifos (LC 90-95, 0.05-0.1 ppm) than to temephos. The susceptibility levels of other indicator species such as Agrion, Hydropsyche, Brachycentrus, Ephemera, etc. are discussed in relation to susceptibility levels of Simulium larvae under the same test conditions, and also in relation to current field dosages of the two insecticides in practical and experimental Simulium control.

  5. Sharing Annotated Audio Recordings of Clinic Visits With Patients-Development of the Open Recording Automated Logging System (ORALS): Study Protocol.

    Science.gov (United States)

    Barr, Paul J; Dannenberg, Michelle D; Ganoe, Craig H; Haslett, William; Faill, Rebecca; Hassanpour, Saeed; Das, Amar; Arend, Roger; Masel, Meredith C; Piper, Sheryl; Reicher, Haley; Ryan, James; Elwyn, Glyn

    2017-07-06

    Providing patients with recordings of their clinic visits enhances patient and family engagement, yet few organizations routinely offer recordings. Challenges exist for organizations and patients, including data safety and navigating lengthy recordings. A secure system that allows patients to easily navigate recordings may be a solution. The aim of this project is to develop and test an interoperable system to facilitate routine recording, the Open Recording Automated Logging System (ORALS), with the aim of increasing patient and family engagement. ORALS will consist of (1) technically proficient software using automated machine learning technology to enable accurate and automatic tagging of in-clinic audio recordings (tagging involves identifying elements of the clinic visit most important to patients [eg, treatment plan] on the recording) and (2) a secure, easy-to-use Web interface enabling the upload and accurate linkage of recordings to patients, which can be accessed at home. We will use a mixed methods approach to develop and formatively test ORALS in 4 iterative stages: case study of pioneer clinics where recordings are currently offered to patients, ORALS design and user experience testing, ORALS software and user interface development, and rapid cycle testing of ORALS in a primary care clinic, assessing impact on patient and family engagement. Dartmouth's Informatics Collaboratory for Design, Development and Dissemination team, patients, patient partners, caregivers, and clinicians will assist in developing ORALS. We will implement a publication plan that includes a final project report and articles for peer-reviewed journals. In addition to this work, we will regularly report on our progress using popular relevant Tweet chats and online using our website, www.openrecordings.org. We will disseminate our work at relevant conferences (eg, Academy Health, Health Datapalooza, and the Institute for Healthcare Improvement Quality Forums). Finally, Iora Health, a

  6. HLA Class I and II Blocks Are Associated to Susceptibility, Clinical Subtypes and Autoantibodies in Mexican Systemic Sclerosis (SSc) Patients

    Science.gov (United States)

    Rodriguez-Reyna, Tatiana S.; Mercado-Velázquez, Pamela; Yu, Neng; Alosco, Sharon; Ohashi, Marina; Lebedeva, Tatiana; Cruz-Lagunas, Alfredo; Núñez-Álvarez, Carlos; Vargas-Alarcón, Gilberto; Granados, Julio; Zúñiga, Joaquin; Yunis, Edmond

    2015-01-01

    Introduction Human leukocyte antigen (HLA) polymorphism studies in Systemic Sclerosis (SSc) have yielded variable results. These studies need to consider the genetic admixture of the studied population. Here we used our previously reported definition of genetic admixture of Mexicans using HLA class I and II DNA blocks to map genetic susceptibility to develop SSc and its complications. Methods We included 159 patients from a cohort of Mexican Mestizo SSc patients. We performed clinical evaluation, obtained SSc-associated antibodies, and determined HLA class I and class II alleles using sequence-based, high-resolution techniques to evaluate the contribution of these genes to SSc susceptibility, their correlation with the clinical and autoantibody profile and the prevalence of Amerindian, Caucasian and African alleles, blocks and haplotypes in this population. Results Our study revealed that class I block HLA-C*12:03-B*18:01 was important to map susceptibility to diffuse cutaneous (dc) SSc, HLA-C*07:01-B*08:01 block to map the susceptibility role of HLA-B*08:01 to develop SSc, and the C*07:02-B*39:05 and C*07:02-B*39:06 blocks to map the protective role of C*07:02 in SSc. We also confirmed previous associations of HLA-DRB1*11:04 and –DRB1*01 to susceptibility to develop SSc. Importantly, we mapped the protective role of DQB1*03:01 using three Amerindian blocks. We also found a significant association for the presence of anti-Topoisomerase I antibody with HLA-DQB1*04:02, present in an Amerindian block (DRB1*08:02-DQB1*04:02), and we found several alleles associated to internal organ damage. The admixture estimations revealed a lower proportion of the Amerindian genetic component among SSc patients. Conclusion This is the first report of the diversity of HLA class I and II alleles and haplotypes Mexican patients with SSc. Our findings suggest that HLA class I and class II genes contribute to the protection and susceptibility to develop SSc and its different clinical

  7. PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update.

    Science.gov (United States)

    de Lima, Suelen Cristina; Adelino, José Eduardo; Crovella, Sergio; de Azevedo Silva, Jaqueline; Sandrin-Garcia, Paula

    2017-11-01

    Studies performed in the past years showed PTNP22 1858 C > T (rs2476601) polymorphism as associated with systemic lupus erythematosus susceptibility, although conflicting findings are still found. In this context, a powerful statistical study, such as meta-analysis, is necessary to establish a consensus. The aim of this study was to evaluate association studies between the PTPN22 1858 C > T polymorphism and SLE by a meta-analysis update, including three recently published studies in the last three years. A total of 3868 SLE patients and 7458 healthy individuals were considered herein, enclosing 19 studies from Asian, American, European and Latin ethnic groups. Odds ratio (OR) was performed for allelic, dominant and recessive genetic models. Statistically significant association was found between the PTPN22 1858 C > T polymorphism and susceptibility to SLE in all inheritance models. Allelic genetic model data (OR = 1.54, 95% confidence interval (CI) = 1.38-1.72, p value=.000) shows that T allele confers increased SLE susceptibility. As well as recessive genetic model (OR = 2.04, 95% CI = 1.09-3.82, p value = .030) for T/T genotype. Instead, dominant genetic model shows that C/C genotype confers lower susceptibility for SLE development (OR = 0.62, 95% CI = 0.54-0.72, p value = .000). In addition, we provided an ethnicity-derived meta-analysis. The results showed association in Caucasian (OR = 1.47, p value = .000) and Latin (OR = 2.41, p value = .000) ethnic groups. However, rs2476601 polymorphism is not associated nor in Asian (OR= 1.31; p value = .54) and African (OR = 2.04; p value=.22) populations. In conclusion, present meta-analysis update confirms that T allele and T/T genotype in PTPN22 1858 C > T polymorphism confers SLE susceptibility, particular in Caucasian and Latin groups, suggesting PTPN22 1858 C > T as a potential genetic marker in SLE susceptibility.

  8. Evaluation of an Automated System for Reading and Interpreting Disk Diffusion Antimicrobial Susceptibility Testing of Fastidious Bacteria.

    Directory of Open Access Journals (Sweden)

    Evgeny A Idelevich

    Full Text Available Results of disk diffusion antimicrobial susceptibility testing depend on individual visual reading of inhibition zone diameters. Therefore, automated reading using camera systems might represent a useful tool for standardization. In this study, the ADAGIO automated system (Bio-Rad was evaluated for reading disk diffusion tests of fastidious bacteria. 144 clinical isolates (68 β-haemolytic streptococci, 28 Streptococcus pneumoniae, 18 viridans group streptococci, 13 Haemophilus influenzae, 7 Moraxella catarrhalis, and 10 Campylobacter jejuni were tested on Mueller-Hinton agar supplemented with 5% defibrinated horse blood and 20 mg/L β-NAD (MH-F, Oxoid according to EUCAST. Plates were read manually with a ruler and automatically using the ADAGIO system. Inhibition zone diameters, indicated by the automated system, were visually controlled and adjusted, if necessary. Among 1548 isolate-antibiotic combinations, comparison of automated vs. manual reading yielded categorical agreement (CA without visual adjustment of the automatically determined zone diameters in 81.4%. In 20% (309 of 1548 of tests it was deemed necessary to adjust the automatically determined zone diameter after visual control. After adjustment, CA was 94.8%; very major errors (false susceptible interpretation, major errors (false resistant interpretation and minor errors (false categorization involving intermediate result, calculated according to the ISO 20776-2 guideline, accounted to 13.7% (13 of 95 resistant results, 3.3% (47 of 1424 susceptible results and 1.4% (21 of 1548 total results, respectively, compared to manual reading. The ADAGIO system allowed for automated reading of disk diffusion testing in fastidious bacteria and, after visual validation of the automated results, yielded good categorical agreement with manual reading.

  9. Flood susceptibility assessment in Hengfeng area coupling adaptive neuro-fuzzy inference system with genetic algorithm and differential evolution.

    Science.gov (United States)

    Hong, Haoyuan; Panahi, Mahdi; Shirzadi, Ataollah; Ma, Tianwu; Liu, Junzhi; Zhu, A-Xing; Chen, Wei; Kougias, Ioannis; Kazakis, Nerantzis

    2017-10-23

    Floods are among Earth's most common natural hazards, and they cause major economic losses and seriously affect peoples' lives and health. This paper addresses the development of a flood susceptibility assessment that uses intelligent techniques and GIS. An adaptive neuro-fuzzy inference system (ANFIS) was coupled with a genetic algorithm and differential evolution for flood spatial modelling. The model considers thirteen hydrologic, morphologic and lithologic parameters for the flood susceptibility assessment, and Hengfeng County in China was chosen for the application of the model due to data availability and the 195 total flood events. The flood locations were randomly divided into two subsets, namely, training (70% of the total) and testing (30%). The Step-wise Weight Assessment Ratio Analysis (SWARA) approach was used to assess the relation between the floods and influencing parameters. Subsequently, two data mining techniques were combined with the ANFIS model, including the ANFIS-Genetic Algorithm and the ANFIS-Differential Evolution, to be used for flood spatial modelling and zonation. The flood susceptibility maps were produced, and their robustness was checked using the Receiver Operating Characteristic (ROC) curve. The results showed that the area under the curve (AUC) for all models was >0.80. The highest AUC value was for the ANFIS-DE model (0.852), followed by ANFIS-GA (0.849). According to the RMSE and MSE methods, the ANFIS-DE hybrid model is more suitable for flood susceptibility mapping in the study area. The proposed method is adaptable and can easily be applied in other sites for flood management and prevention. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Logs Wanted - Dead or Alive

    Science.gov (United States)

    Schuchardt, A.; Morche, D.

    2015-12-01

    Rivers cover only a small part of the Earth`s surface, yet they transfer sediment in globally significant quantities. In mountainous regions, the majority of the total channel length occurs in headwater streams. Those mountain channels are influenced in terms of sediment connectivity by processes on the slopes. For example in such a sediment routing system, sediment originating from debris flows on the slopes is delivered along sediment pathways to the channel system and can be transported further downstream as solid load. Interruption of instream coarse sediment connectivity is closely related to the existence of channel blocking barriers which also can be formed by biota. By storing sediment large wood (LW) log jams disrupt in-channel sediment connectivity. We present a study design in order to decipher the short to long term effects (c. 10-2-102 years) of sediment (dis)connectivity effects of large wood. The study areas are two basins in mountain ranges in Germany and Austria. In Austria the drainage area of the river Fugnitz was chosen which is located in the National Park Thayatal. The other drainage area of the river Sieber in Saxony-Anhalt, Germany, is located in the Harz National Park. Since studies on LW and its geomorphological effects in Central European rivers are still rare the main goals of the project are: •to identify important triggers for LW transport from slopes into the channels •to examine the spatial distribution and characterization of LW in main and slope channels by mapping and dGPS measurements •to determine the effects of LW on channel hydraulic parameters (e.g. slope, width, grains size composition, roughness) by field measurements of channel long profiles and cross section with dGPS and Wolman particle counts •to quantify the direct effects of LW on discharge and bed load transport by measuring flow velocity with an Ott-Nautilus current meter and to measure bed load up- and downstream of log jams using a portable Helley

  11. Lithostratigraphy from downhole logs in Hole AND-1B, Antarctica

    Science.gov (United States)

    Williams, Trevor; Morin, Roger H.; Jarrard, Richard D.; Jackolski, Chris L.; Henrys, Stuart A.; Niessen, Frank; Magens, Diana; Kuhn, Gerhard; Monien, Donata; Powell, Ross D.

    2012-01-01

    The ANDRILL (Antarctic Drilling Project) McMurdo Ice Shelf (MIS) project drilled 1285 m of sediment in Hole AND–1B, representing the past 12 m.y. of glacial history. Downhole geophysical logs were acquired to a depth of 1018 mbsf (meters below seafloor), and are complementary to data acquired from the core. The natural gamma radiation (NGR) and magnetic susceptibility logs are particularly useful for understanding lithological and paleoenvironmental change at ANDRILL McMurdo Ice Shelf Hole AND–1B. NGR logs cover the entire interval from the seafloor to 1018 mbsf, and magnetic susceptibility and other logs covered the open hole intervals between 692 and 1018 and 237–342 mbsf. In the upper part of AND–1B, clear alternations between low and high NGR values distinguish between diatomite (lacking minerals containing naturally radioactive K, U, and Th) and diamictite (containing K-bearing clays, K-feldspar, mica, and heavy minerals). In the lower open hole logged section, NGR and magnetic susceptibility can also distinguish claystones (rich in K-bearing clay minerals, relatively low in magnetite) and diamictites (relatively high in magnetite). Sandstones can be distinguished by their high resistivity values in AND–1B. On the basis of these three downhole logs, diamictite, claystones, and sandstones can be predicted correctly for 74% of the 692–1018 mbsf interval. The logs were then used to predict facies for the 6% of this interval that was unrecovered by coring. Given the understanding of the physical property characteristics of different facies, it is also possible to identify subtle changes in lithology from the physical properties and help refine parts of the lithostratigraphy, for example, the varying terrigenous content of diatomites and the transitions from subice diamictite to open-water diatomite.

  12. Investigating flood susceptible areas in inaccessible regions using remote sensing and geographic information systems.

    Science.gov (United States)

    Lim, Joongbin; Lee, Kyoo-Seock

    2017-03-01

    Every summer, North Korea (NK) suffers from floods, resulting in decreased agricultural production and huge economic loss. Besides meteorological reasons, several factors can accelerate flood damage. Environmental studies about NK are difficult because NK is inaccessible due to the division of Korea. Remote sensing (RS) can be used to delineate flood inundated areas in inaccessible regions such as NK. The objective of this study was to investigate the spatial characteristics of flood susceptible areas (FSAs) using multi-temporal RS data and digital elevation model data. Such study will provide basic information to restore FSAs after reunification. Defining FSAs at the study site revealed that rice paddies with low elevation and low slope were the most susceptible areas to flood in NK. Numerous sediments from upper streams, especially streams through crop field areas on steeply sloped hills, might have been transported and deposited into stream channels, thus disturbing water flow. In conclusion, NK floods may have occurred not only due to meteorological factors but also due to inappropriate land use for flood management. In order to mitigate NK flood damage, reforestation is needed for terraced crop fields. In addition, drainage capacity for middle stream channel near rice paddies should be improved.

  13. Real Time Face Quality Assessment for Face Log Generation

    DEFF Research Database (Denmark)

    Kamal, Nasrollahi; Moeslund, Thomas B.

    2009-01-01

    Summarizing a long surveillance video to just a few best quality face images of each subject, a face-log, is of great importance in surveillance systems. Face quality assessment is the back-bone for face log generation and improving the quality assessment makes the face logs more reliable. Develo....... Developing a real time face quality assessment system using the most important facial features and employing it for face logs generation are the concerns of this paper. Extensive tests using four databases are carried out to validate the usability of the system....

  14. Flow cytometry as a tool to identify Mycobacterium tuberculosis interaction with the immune system and drug susceptibility

    Directory of Open Access Journals (Sweden)

    Maria da Gloria Bonecini-Almeida

    2000-08-01

    Full Text Available Flow cytometric analysis is a useful and widely employed tool to identify immunological alterations caused by different microorganisms, including Mycobacterium tuberculosis. However, this tool can be used for several others analysis. We will discuss some applications for flow cytometry to the study of M. tuberculosis, mainly on cell surface antigens, mycobacterial secreted proteins, their interaction with the immune system using inflammatory cells recovered from peripheral blood, alveolar and pleura spaces and the influence of M. tuberculosis on apoptosis, and finally the rapid determination of drug susceptibility. All of these examples highlight the usefulness of flow cytometry in the study of M. tuber-culosis infection.

  15. Well log characterization of natural gas hydrates

    Science.gov (United States)

    Collett, Timothy S.; Lee, Myung W.

    2011-01-01

    In the last 25 years we have seen significant advancements in the use of downhole well logging tools to acquire detailed information on the occurrence of gas hydrate in nature: From an early start of using wireline electrical resistivity and acoustic logs to identify gas hydrate occurrences in wells drilled in Arctic permafrost environments to today where wireline and advanced logging-while-drilling tools are routinely used to examine the petrophysical nature of gas hydrate reservoirs and the distribution and concentration of gas hydrates within various complex reservoir systems. The most established and well known use of downhole log data in gas hydrate research is the use of electrical resistivity and acoustic velocity data (both compressional- and shear-wave data) to make estimates of gas hydrate content (i.e., reservoir saturations) in various sediment types and geologic settings. New downhole logging tools designed to make directionally oriented acoustic and propagation resistivity log measurements have provided the data needed to analyze the acoustic and electrical anisotropic properties of both highly inter-bedded and fracture dominated gas hydrate reservoirs. Advancements in nuclear-magnetic-resonance (NMR) logging and wireline formation testing have also allowed for the characterization of gas hydrate at the pore scale. Integrated NMR and formation testing studies from northern Canada and Alaska have yielded valuable insight into how gas hydrates are physically distributed in sediments and the occurrence and nature of pore fluids (i.e., free-water along with clay and capillary bound water) in gas-hydrate-bearing reservoirs. Information on the distribution of gas hydrate at the pore scale has provided invaluable insight on the mechanisms controlling the formation and occurrence of gas hydrate in nature along with data on gas hydrate reservoir properties (i.e., permeabilities) needed to accurately predict gas production rates for various gas hydrate

  16. An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes.

    Directory of Open Access Journals (Sweden)

    Ling Bai

    2016-04-01

    Full Text Available Metastasis remains the primary cause of patient morbidity and mortality in solid tumors and is due to the action of a large number of tumor-autonomous and non-autonomous factors. Here we report the results of a genome-wide integrated strategy to identify novel metastasis susceptibility candidate genes and molecular pathways in breast cancer metastasis. This analysis implicates a number of transcriptional regulators and suggests cell-mediated immunity is an important determinant. Moreover, the analysis identified novel or FDA-approved drugs as potentially useful for anti-metastatic therapy. Further explorations implementing this strategy may therefore provide a variety of information for clinical applications in the control and treatment of advanced neoplastic disease.

  17. WMS -Warehouse Management System: adaptação proposta para o gerenciamento da logística reversa WMS -Warehouse Management System: adaptation propused for the management of the reverse logistics

    Directory of Open Access Journals (Sweden)

    Patrícia Guarnieri

    2006-04-01

    Full Text Available Com o advento da globalização, e o conseqüente atendimento a mercados distantes e alta rotatividade dos estoques, os armazéns descartam quantidades enormes de materiais ao final do processo logístico. Estes materiais, além de representarem considerável valor econômico, podem causar danos ao meio ambiente se descartados de forma indiscriminada. Umas das formas de evitar estes problemas, é através da adoção de técnicas de Gerenciamento da Cadeia de Suprimentos Reversa. Para que estas técnicas sejam colocadas em prática em larga escala, são necessários Sistemas para o Gerenciamento da Cadeia de Suprimentos Reversa. Como estes sistemas praticamente inexistem no mercado, este artigo propõe uma adaptação do WMS tradicional, de forma a ser possível utilizá-lo também para o gerenciamento da cadeia de suprimentos reversa. A metodologia proposta evidencia que a maioria das funções do WMS tradicionalmente utilizadas para gerenciar a logística direta também pode ser utilizada na logística reversa.With the advent of the globalization, warehouses serves distant markets and presents a very low stock turnaround time. In this process, huge quantities of materials are discarded at the end of the logistics chain. These materials represent a considerable financial ammount and, if improperly discarded, can cause an environmental disaster. In order to avoid these problems, reverse supply chain management techniques are used. On order to implement these techniques, reverse supply chain management systems are needed. As this kind of systems are almost inexistent, this article suggests the adaptation of the traditional WMS systems in order to be useful in the management of the reverse supply chain management. The proposed methodology shows that the major functions found in present WMS systems can also be used for reverse supply chain management.

  18. Review of log sort yards

    Science.gov (United States)

    John Rusty Dramm; Gerry L. Jackson; Jenny Wong

    2002-01-01

    This report provides a general overview of current log sort yard operations in the United States, including an extensive literature review and information collected during on-site visits to several operations throughout the nation. Log sort yards provide many services in marketing wood and fiber by concentrating, merchandising, processing, sorting, and adding value to...

  19. SNG-logs at Skjern

    DEFF Research Database (Denmark)

    Korsbech, Uffe C C; Petersen, Jesper; Aage, Helle Karina

    1998-01-01

    Spectral Natural Gamma-ray logs have been run in two water supply borings at Skjern. The log data have been examined by a new technique - Noise Adjusted Singular Value Decomposition - in order to get a detailed and reliable picture of the distribution of uranium and thorium gamma-rays from heavy...

  20. Ubiquitous Learning Project Using Life-Logging Technology in Japan

    Science.gov (United States)

    Ogata, Hiroaki; Hou, Bin; Li, Mengmeng; Uosaki, Noriko; Mouri, Kosuke; Liu, Songran

    2014-01-01

    A Ubiquitous Learning Log (ULL) is defined as a digital record of what a learner has learned in daily life using ubiquitous computing technologies. In this paper, a project which developed a system called SCROLL (System for Capturing and Reusing Of Learning Log) is presented. The aim of developing SCROLL is to help learners record, organize,…

  1. A Systems Genetic Approach to Identify Low Dose Radiation-Induced Lymphoma Susceptibility/DOE2013FinalReport

    Energy Technology Data Exchange (ETDEWEB)

    Balmain, Allan [University of California, San Francisco; Song, Ihn Young [University of California, San Francisco

    2013-05-15

    The ultimate goal of this project is to identify the combinations of genetic variants that confer an individual's susceptibility to the effects of low dose (0.1 Gy) gamma-radiation, in particular with regard to tumor development. In contrast to the known effects of high dose radiation in cancer induction, the responses to low dose radiation (defined as 0.1 Gy or less) are much less well understood, and have been proposed to involve a protective anti-tumor effect in some in vivo scientific models. These conflicting results confound attempts to develop predictive models of the risk of exposure to low dose radiation, particularly when combined with the strong effects of inherited genetic variants on both radiation effects and cancer susceptibility. We have used a Systems Genetics approach in mice that combines genetic background analysis with responses to low and high dose radiation, in order to develop insights that will allow us to reconcile these disparate observations. Using this comprehensive approach we have analyzed normal tissue gene expression (in this case the skin and thymus), together with the changes that take place in this gene expression architecture a) in response to low or high- dose radiation and b) during tumor development. Additionally, we have demonstrated that using our expression analysis approach in our genetically heterogeneous/defined radiation-induced tumor mouse models can uniquely identify genes and pathways relevant to human T-ALL, and uncover interactions between common genetic variants of genes which may lead to tumor susceptibility.

  2. Magnetic susceptibility and electron–phonon (e–p) interaction in some U and Ce based heavy fermion (HF) systems

    Energy Technology Data Exchange (ETDEWEB)

    Sahoo, J., E-mail: jitendrasahoo2008@gmail.com [Regional Office of Vocational Education, Sambalpur, Odisha 768004 (India); Shadangi, N. [Department of Physics, Silicon Institute of Technology, Sambalpur, Odisha 768200 (India); Nayak, P. [School of Physics, Sambalpur University, Sambalpur, Odisha 768019 (India)

    2015-03-15

    Here an attempt is made to explore the variation of magnetic susceptibility with temperature for different values of the position of f-level (d) and electron–phonon interaction (EPI) strength (r) in some U and Ce based heavy Fermion (HF) systems within Periodic Anderson Model (PAM) in the presence of a static magnetic field B and interaction of phonons with electrons of hybridization band. Since magnetic susceptibility χ is related to the f-electron occupation n{sub ±σ}{sup f}, the expression for the latter is analytically derived through f–f correlation function following the Green function technique of Zubarev. The numerical analysis of χ as a function of temperature ‘T’ is done for different values of d and r. The results show a good agreement with the experiments for some U and Ce based HFs. An explanation for the existence of a critical value of d w.r.t. E{sub F} for switching of nature of χ∼T from U to Ce based HF systems is provided. Our calculated value of the temperature T{sub χmax} corresponding to the peak position of χ for small values of hybridization constant γ=0.002 and 0.0036 coincides with the experimental value of 19 K for UPt{sub 3} and 35 K for UPd{sub 2}Al{sub 3} reported by Frings et al. and Geibel et al. respectively. - Highlights: • Variation of magnetic susceptibility χ with temperature T is studied for some HF systems. • Periodic Anderson Model in presence of magnetic field and electron–phonon interaction is used for numerical evaluation. • The existence of a critical value of the position of f-level(d) is proposed for distinction between χ∼T behavior of U and Ce based HF systems. • Results obtained are in good agreement with the experimental observations for some Ce and U based HF systems. • Theoretically evaluated temperature corresponding to the peak value of χ matches with the experimental results of UPt{sub 3} and UPd{sub 2}Al{sub 3}.

  3. Dynamic magnetic susceptibility of systems with long-range magnetic order

    Energy Technology Data Exchange (ETDEWEB)

    Vannette, Matthew Dano [Iowa State Univ., Ames, IA (United States)

    2009-01-01

    The utility of the TDR as an instrument in the study of magnetically ordered materials has been expanded beyond the simple demonstration purposes. Results of static applied magnetic field dependent measurements of the dynamic magnetic susceptibility, χ, of various ferromagnetic (FM) and antiferromagnetic (AFM) materials showing a range of transition temperatures (1-800 K) are presented. Data was collected primarily with a tunnel diode resonator (TDR) at different radio-frequencies (~10-30 MHz). In the vicinity of TC local moment ferromagnets show a very sharp, narrow peak in χ which is suppressed in amplitude and shifted to higher temperatures as the static bias field is increased. Unexpectedly, critical scaling analysis fails for these data. It is seen that these data are frequency dependent, however there is no simple method whereby measurement frequency can be changed in a controllable fashion. In contrast, itinerant ferromagnets show a broad maximum in χ well below TC which is suppressed and shifts to lower temperatures as the dc bias field is increased. The data on itinerant ferromagnets is fitted to a semi-phenomenological model that suggests the sample response is dominated by the uncompensated minority spins in the conduction band. Concluding remarks suggest possible scenarios to achieve frequency resolved data using the TDR as well as other fields in which the apparatus may be exploited.

  4. Evaluation of the ESP Culture System II for Testing Susceptibilities of Mycobacterium tuberculosis Isolates to Four Primary Antituberculous Drugs

    Science.gov (United States)

    Bergmann, John S.; Woods, Gail L.

    1998-01-01

    The reliability of the ESP Culture System II (herein referred to as ESP II) for testing susceptibilities of Mycobacterium tuberculosis isolates to isoniazid, rifampin, ethambutol, and streptomycin was evaluated by comparing results to those of the method of proportion (MOP), which was considered the reference method, for 20 clinical isolates and 30 challenge strains provided by the Centers for Disease Control and Prevention (CDC). Clinical isolates also were tested with the BACTEC TB 460 system; these results agreed with those obtained by the MOP for all isolates and all drugs, except the high concentration of isoniazid, for which agreement was 95%. After resolution of discrepancies, levels of agreement between ESP II and MOP for the clinical isolates were 95 and 100%, respectively, for the low and high concentrations of isoniazid, 100% for rifampin and ethambutol, and 95% for streptomycin. For the 30 challenge isolates, ESP II results for both concentrations of isoniazid agreed with the expected results in all cases, whereas agreement was 93% for both rifampin and streptomycin and 90% for ethambutol. All discrepancies with the CDC isolates were due to failure of ESP II to correctly classify resistant strains. By testing isolates yielding discrepant ethambutol and streptomycin results with a lower concentration of both drugs in the ESP II system, agreement increased to 93% for ethambutol and 100% for streptomycin. For the clinical isolates, the times to an ESP II result of susceptible (means ± standard errors of the means) were 8.47 ± 0.12 days (range, 7 to 10 days) and 8.73 ± 0.29 days (range, 5 to 11 days) when the inoculum was prepared from a McFarland equivalent and from a seed bottle, respectively. The time to an ESP II result of resistant varied by drug and method of inoculum preparation, ranging from 5.50 ± 0.22 days for ethambutol with the inoculum prepared from a McFarland standard to 8.0 days for ethambutol with the inoculum prepared from a seed

  5. Combined Log Inventory and Process Simulation Models for the Planning and Control of Sawmill Operations

    Science.gov (United States)

    Guillermo A. Mendoza; Roger J. Meimban; Philip A. Araman; William G. Luppold

    1991-01-01

    A log inventory model and a real-time hardwood process simulation model were developed and combined into an integrated production planning and control system for hardwood sawmills. The log inventory model was designed to monitor and periodically update the status of the logs in the log yard. The process simulation model was designed to estimate various sawmill...

  6. The Tunisian Jurassic aquifer in the North African Sahara aquifer system: information derived from two-dimensional seismic reflection and well logs

    Science.gov (United States)

    Ben Lasmar, Rafika; Guellala, Rihab; Garrach, Mohamed; Mahroug, Ali; Sarsar Naouali, Benen; Inoubli, Mohamed Hédi

    2017-12-01

    Southern Tunisia is an arid area where socio-economic activities are dependent on groundwater resources. The presented study aims to better characterize the Jurassic aquifer based on geological and geophysical data, with a view to develop a rational exploitation program. Well logs are used to precisely determine the position and composition of the known Jurassic aquifer layers and to identify others able to produce good quality water. The logs show that limestones, sandstones and dolomites of the Krachoua, Techout and Foum Tataouine formations are the main Jurassic aquifers. Sixty-eight seismic-reflection sections are integrated within this study. The interpolation between the interpreted sections leads to the construction of isochronous isopach maps and geoseismic sections, and their analysis finds that compressive and extensive tectonic deformations have influenced the Jurassic aquifer geometry. The Hercynian orogeny phase manifestation is remarkable in that there are several stratigraphic gaps in the Jurassic sequence. The E-W, NW-SE, and NNW-SSE accidents, reactivated in normal faults since the Permian to Lower Cretaceous epochs, have generated the structures found in the Jurassic series, such as subsided and raised blocks. Their syn-sedimentary activity has controlled the thickness and facies of these series. The Cretaceous, Tortonian and Post-Villafranchian compressions are responsible for the Jurassic-deposits folding in some localities. The highlighted tectonic and sedimentary events have an important impact on the Jurassic aquifer function by favoring the Jurassic aquifer interconnections and their connections with the Triassic and Cretaceous permeable series.

  7. The Tunisian Jurassic aquifer in the North African Sahara aquifer system: information derived from two-dimensional seismic reflection and well logs

    Science.gov (United States)

    Ben Lasmar, Rafika; Guellala, Rihab; Garrach, Mohamed; Mahroug, Ali; Sarsar Naouali, Benen; Inoubli, Mohamed Hédi

    2017-07-01

    Southern Tunisia is an arid area where socio-economic activities are dependent on groundwater resources. The presented study aims to better characterize the Jurassic aquifer based on geological and geophysical data, with a view to develop a rational exploitation program. Well logs are used to precisely determine the position and composition of the known Jurassic aquifer layers and to identify others able to produce good quality water. The logs show that limestones, sandstones and dolomites of the Krachoua, Techout and Foum Tataouine formations are the main Jurassic aquifers. Sixty-eight seismic-reflection sections are integrated within this study. The interpolation between the interpreted sections leads to the construction of isochronous isopach maps and geoseismic sections, and their analysis finds that compressive and extensive tectonic deformations have influenced the Jurassic aquifer geometry. The Hercynian orogeny phase manifestation is remarkable in that there are several stratigraphic gaps in the Jurassic sequence. The E-W, NW-SE, and NNW-SSE accidents, reactivated in normal faults since the Permian to Lower Cretaceous epochs, have generated the structures found in the Jurassic series, such as subsided and raised blocks. Their syn-sedimentary activity has controlled the thickness and facies of these series. The Cretaceous, Tortonian and Post-Villafranchian compressions are responsible for the Jurassic-deposits folding in some localities. The highlighted tectonic and sedimentary events have an important impact on the Jurassic aquifer function by favoring the Jurassic aquifer interconnections and their connections with the Triassic and Cretaceous permeable series.

  8. Linking susceptibility to infectious diseases to immune system abnormalities among HIV Exposed Uninfected Infants

    Directory of Open Access Journals (Sweden)

    Candice Ruck

    2016-08-01

    Full Text Available HIV exposed, uninfected (HEU infants have been shown to have an increase in overall mortality from infectious causes when compared to HIV unexposed, uninfected (HU infants. This is the case in both resource-rich and resource-limited settings. We explore here the concept that specific types of infectious diseases that are more common among HEU infants could provide clues as to the potential underlying immunological abnormalities. The most commonly reported infections in HEU vs. HU are caused by encapsulated bacteria; this suggests the existence of a less effective humoral (antibody, complement immune response. Decreased transplacental transfer of protective maternal antibodies has been seen consistently among HEU newborns, suggesting that this may indeed be one of the key drivers of their susceptibility to infections with encapsulated bacteria. Reassuringly, HEU humoral response to vaccination appears to be well conserved. While there appears to be an increase in overall incidence of acute viral infections, no specific pattern of acute viral infections has emerged; and while there is evidence of increased chronic viral infection from perinatal transmission of hepatitis C and CMV, no data exist to suggest an increase in adverse outcomes. Thus, no firm conclusions about anti-viral effector mechanisms can be drawn. However, the most unusual of reported infections among the HEU have been opportunistic infections, suggesting the possibility of underlying defects in CD4 helper and overall immune regulatory function. This may relate to the observation that the immunological profile of HEUs indicate more activated T cell profile as well as a more inflammatory innate immune response. However, both of these observations appear temporary, marked in early infancy, but no longer evident later in life. The causes of these changes in early life immune profile are likely multifactorial and may be related to in utero exposure to HIV, but also to increased

  9. Two-component signal transduction system SaeRS is involved in competence and penicillin susceptibility in Staphylococcus epidermidis.

    Science.gov (United States)

    Lou, Qiang; Ma, Yuanfang; Qu, Di

    2016-04-01

    Staphylococcus epidermidis, which is a causative pathogen of nosocomial infection, expresses its virulent traits such as biofilm and autolysis regulated by two-component signal transduction system SaeRS. In this study, the S. epidermidis SaeRS was identified to negatively regulate the expression of genes involved in competence (comF, murF), cytolysis (lrgA), and autolysis (lytS) by DNA microarray or real-time RT-PCR analysis. In addition, saeRS mutant showed increased competence and higher susceptibility to antibiotics such as penicillin and oxacillin than the wild-type strain. The study will be helpful for understanding the characterization of the SaeRS in S. epidermidis. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Drought stress leads to systemic induced susceptibility to a nectrotrophic fungus associated with mountain pine beetle in Pinus banksiana seedlings.

    Directory of Open Access Journals (Sweden)

    Jennifer G Klutsch

    Full Text Available Conifers have complex defense responses to initial attacks by insects and pathogens that can have cascading effects on success of subsequent colonizers. However, drought can affect a plant's ability to respond to biotic agents by potentially altering the resources needed for the energetically costly production of induced defense chemicals. We investigated the impact of reduced water on induced chemical defenses of jack pine (Pinus banksiana seedlings from initial attack by biotic agents and resistance to subsequent challenge inoculation with a pathogenic fungal associate of mountain pine beetle (Dendroctonus ponderosae, Grosmannia clavigera. Applications of phytohormones (methyl salicylate and methyl jasmonate and G. clavigera were used for initial induction of defenses. Monoterpene concentrations varied with initial induction from fungal and phytohormone application while watering treatment had no effect. Seedlings treated with G. clavigera and methyl jasmonate had the greatest monoterpene concentrations compared to the control and methyl salicylate-treated seedlings. However, the monoterpene response to the challenge inoculation varied with watering treatments, not with prior induction treatments, with lower monoterpene concentrations in fungal lesions on seedlings in the low to moderate watering treatments compared to normal watering treatment. Furthermore, prior induction from phytohormones resulted in systemic cross-induction of resistance to G. clavigera under normal watering treatment but susceptibility under low watering treatment. Seedlings stressed by low water conditions, which also had lower stomatal conductance than seedlings in the normal watering treatment, likely allocated resources to initial defense response but were left unable to acquire further resources for subsequent responses. Our results demonstrate that drought can affect interactions among tree-infesting organisms through systemic cross-induction of susceptibility.

  11. Drought stress leads to systemic induced susceptibility to a nectrotrophic fungus associated with mountain pine beetle in Pinus banksiana seedlings.

    Science.gov (United States)

    Klutsch, Jennifer G; Shamoun, Simon Francis; Erbilgin, Nadir

    2017-01-01

    Conifers have complex defense responses to initial attacks by insects and pathogens that can have cascading effects on success of subsequent colonizers. However, drought can affect a plant's ability to respond to biotic agents by potentially altering the resources needed for the energetically costly production of induced defense chemicals. We investigated the impact of reduced water on induced chemical defenses of jack pine (Pinus banksiana) seedlings from initial attack by biotic agents and resistance to subsequent challenge inoculation with a pathogenic fungal associate of mountain pine beetle (Dendroctonus ponderosae), Grosmannia clavigera. Applications of phytohormones (methyl salicylate and methyl jasmonate) and G. clavigera were used for initial induction of defenses. Monoterpene concentrations varied with initial induction from fungal and phytohormone application while watering treatment had no effect. Seedlings treated with G. clavigera and methyl jasmonate had the greatest monoterpene concentrations compared to the control and methyl salicylate-treated seedlings. However, the monoterpene response to the challenge inoculation varied with watering treatments, not with prior induction treatments, with lower monoterpene concentrations in fungal lesions on seedlings in the low to moderate watering treatments compared to normal watering treatment. Furthermore, prior induction from phytohormones resulted in systemic cross-induction of resistance to G. clavigera under normal watering treatment but susceptibility under low watering treatment. Seedlings stressed by low water conditions, which also had lower stomatal conductance than seedlings in the normal watering treatment, likely allocated resources to initial defense response but were left unable to acquire further resources for subsequent responses. Our results demonstrate that drought can affect interactions among tree-infesting organisms through systemic cross-induction of susceptibility.

  12. Association of the tumor necrosis factor alpha gene polymorphism with susceptibility and clinical-immunological findings of systemic lupus erythematosus.

    Science.gov (United States)

    Azizah, M R; Kuak, S H; Ainol, S S; Rahim, M N; Normaznah, Y; Norella, K

    2004-01-01

    The etiology of systemic lupus erythematosus (SLE) is unknown but genetic factors seem to play a role in the disease pathogenesis. The tumor necrosis factor alpha (TNFa) gene, encoded at the TNF locus in the MHC class III region, is now known to be an important candidate gene in SLE, due to the proinflammatory activities of the TNFa. The objectives of this study were to examine the role of the TNFa polymorphism for the susceptibility of Malaysian Chinese lupus patients to SLE and to determine its association with organ involvement. The allelic frequencies of the TNFa polymorphic variant (TNF2) of seventy lupus patients were determined during follow-up at the Medical Clinic of the National University Hospital Malaysia by PCR-RFLP technique. Sixty-four females and 6 males with a mean age of 33+/-12 years were included. Clinical data were obtained from case records. Autoantibody levels were measured by ELISA. Fifty-nine ethnically-matched blood donors were used as controls. The allelic frequency of the TNF2 variant was found to be significantly increased in the patients compared to the controls (52.8% vs 33.8%). SLE patients with the polymorphic TNF2 variant were found to be at increased risk of central nervous system involvement (p = 0.004, RR = 2.59) and to have an increased frequency of anti-La antibodies (p = 0.03). In view of these findings we suggest that TNF2 variant is playing a role in conferring susceptibility to SLE and in the disease pathogenesis.

  13. Acoustic sorting models for improved log segregation

    Science.gov (United States)

    Xiping Wang; Steve Verrill; Eini Lowell; Robert J. Ross; Vicki L. Herian

    2013-01-01

    In this study, we examined three individual log measures (acoustic velocity, log diameter, and log vertical position in a tree) for their ability to predict average modulus of elasticity (MOE) and grade yield of structural lumber obtained from Douglas-fir (Pseudotsuga menziesii [Mirb. Franco]) logs. We found that log acoustic velocity only had a...

  14. Palm distributions for log Gaussian Cox processes

    DEFF Research Database (Denmark)

    Coeurjolly, Jean-Francois; Møller, Jesper; Waagepetersen, Rasmus Plenge

    2017-01-01

    This paper establishes a remarkable result regarding Palm distributions for a log Gaussian Cox process: the reduced Palm distribution for a log Gaussian Cox process is itself a log Gaussian Cox process that only differs from the original log Gaussian Cox process in the intensity function. This new...... result is used to study functional summaries for log Gaussian Cox processes....

  15. The Rock Engineering System (RES) applied to landslide susceptibility zonation of the northeastern flank of Etna: methodological approach and results

    Science.gov (United States)

    Apuani, Tiziana; Corazzato, Claudia

    2015-04-01

    Ground deformations in the northeastern flank of Etna are well known. Despite only a few landslide events have been documented, these have significantly involved and damaged lifelines and buildings. These events are mainly related to the activity of the volcano-tectonic structures and associated seismicity, as in the case of the 2002 reactivation of the Presa landslide during an increased activity of the Pernicana fault system. In order to highlight the areal distribution of potentially unstable slopes based on a detailed, site-specific study of the factors responsible for landslide, and to ultimately contribute to risk management, a landslide susceptibility analysis of the northeastern flank of Etna in the Pernicana area was carried out, and a susceptibility map at 1:10.000 scale was produced, extending over an area of 168 km2. Different methods are proposed in the literature to obtain the regional distribution of potentially unstable slopes, depending on the problem scale, the slope dynamic evolution in the geological context, and the availability of data. Among semi-quantitative approaches, the present research combines the Rock Engineering System (RES) methodology with parameter zonation mapping in a GIS environment. The RES method represents a structured approach to manage a high number of interacting factors involved in the instability problem. A numerically coded, site-specific interaction matrix (IM) analyzes the cause-effect relationship in these factors, and calculates the degree of interactivity of each parameter, normalized by the overall interactivity of the system (weight factor). In the specific Etna case, the considered parameters are: slope attitude, lithotechnical properties (lithology, structural complexity, soil and rock mass quality), land use, tectonic structures, seismic activity (horizontal acceleration) and hydrogeological conditions (groundwater and drainage). Thematic maps are prepared at 1:10.000 scale for each of these parameters, and

  16. Trends in Susceptibility Rates and Extended-Spectrum β-Lactamase Production of Klebsiella pneumoniae in Bloodstream Infections Across the United States Veterans Affairs Healthcare System.

    Science.gov (United States)

    Gentry, Chris A; Williams, Riley J

    2015-12-01

    Klebsiella pneumoniae is an important pathogen, increasingly notorious for its ability to become resistant to antimicrobial agents. This study sought to characterize trends in antimicrobial susceptibility rates for K. pneumoniae causing bacteremias across the United States (U.S.) Veterans Healthcare Administration (VHA) from 2007 through 2013 utilizing a national clinical database. K. pneumoniae grew in 9,235 blood cultures from 8,414 patients. Nationally, ampicillin-sulbactam, ceftazidime, cefepime, ertapenem, fluoroquinolones, and amikacin demonstrated statistically significant susceptibility rate increases against K. pneumoniae in the 2010-2013 period versus the 2007-2009 period. No antimicrobial agent had a statistically significant nationwide susceptibility rate decrease. Of the 126 antibiotic-organism pairs tested among 9 U.S. regions, 18 demonstrated statistically significant susceptibility rate increases while 6 demonstrated statistically significant susceptibility rate decreases. The East North Central (eight agents), Mid-Atlantic (five agents), and South Atlantic (four agents) regions demonstrated statistically significant susceptibility rate increases for multiple antimicrobial agents. Of the 70 antibiotic-organism pairs tested among 5 different medical center complexity levels, 11 antibiotics demonstrated statistically significant susceptibility rate increases and 1 demonstrated a statistically significant rate decrease. Extended-spectrum β-lactamase production did not significantly change over the study period across an available nationwide representation of 31 facilities (10.6% in 2007-2009 vs. 9.21% in 2010-2013, p=0.17). The South Atlantic and Mid-Atlantic regions had the highest prevalence of extended-spectrum ß-lactamase production in the two periods, respectively. The recent trend of generally increasing susceptibility rates for K. pneumoniae bloodstream isolates in this nationwide U.S. VHA study contrasts from other U.S. health system reports

  17. Debris Flow Susceptibility Assessment in the Wudongde Dam Area, China Based on Rock Engineering System and Fuzzy C-Means Algorithm

    Directory of Open Access Journals (Sweden)

    Yanyan Li

    2017-09-01

    Full Text Available Debris flows in the Wudongde dam area, China could pose a huge threat to the running of the power station. Therefore, it is of great significance to carry out a susceptibility analysis for this area. This paper presents an application of the rock engineering system and fuzzy C-means algorithm (RES_FCM for debris flow susceptibility assessment. The watershed of the Jinsha River close to the Wudongde dam site in southwest China was taken as the study area, where a total of 22 channelized debris flow gullies were mapped by field investigations. Eight environmental parameters were selected for debris flow susceptibility assessment, namely, lithology, watershed area, slope angle, stream density, length of the main stream, curvature of the main stream, distance from fault and vegetation cover ratio. The interactions among these parameters and their weightings were determined using the RES method. A debris flow susceptibility map was produced by dividing the gullies into three categories of debris flow susceptibility based on the susceptibility index (SI using the FCM algorithm. The results show that the susceptibility levels for nine of the debris flow gullies are high, nine are moderate and four are low, respectively. The RES based K-means algorithm (RES_KM was used for comparison. The results suggest that the RES_FCM method and the RES_KM method provide very close evaluation results for most of the debris flow gullies, which also agree well with field investigations. The prediction accuracy of the new method is 90.9%, larger than that obtained by the RES_KM method (86.4%. Therefore, the RES_FCM method performs better than the RES_KM method for assessing the susceptibility of debris flows.

  18. Individual differences underlying susceptibility to addiction: role for the endogenous oxytocin system

    NARCIS (Netherlands)

    Buisman-Pijlman, F.T.A; Sumracki, N.M.; Gordon, J.J.; Hull, P.R.; Carter, C.S.; Tops, M.

    2014-01-01

    Recent research shows that the effects of oxytocin are more diverse than initially thought and that in some cases oxytocin can directly influence the response to drugs and alcohol. Large individual differences in basal oxytocin levels and reactivity of the oxytocin system exist. This paper will

  19. Influence of TYK2 in systemic sclerosis susceptibility : a new locus in the IL-12 pathway

    NARCIS (Netherlands)

    López-Isac, Elena; Campillo-Davo, Diana; Bossini-Castillo, Lara; Guerra, Sandra G; Assassi, Shervin; Simeón, Carmen Pilar; Carreira, Patricia; Ortego-Centeno, Norberto; García de la Peña, Paloma; Beretta, Lorenzo; Santaniello, Alessandro; Bellocchi, Chiara; Lunardi, Claudio; Moroncini, Gianluca; Gabrielli, Armando; Riemekasten, Gabriela; Witte, Torsten; Hunzelmann, Nicolas; Kreuter, Alexander; Distler, Jörg Hw; Voskuyl, Alexandre E; de Vries-Bouwstra, Jeska; Herrick, Ariane; Worthington, Jane; Denton, Christopher P; Fonseca, Carmen; Radstake, Timothy Rdj; Mayes, Maureen D; Martín, Javier

    OBJECTIVES: TYK2 is a common genetic risk factor for several autoimmune diseases. This gene encodes a protein kinase involved in interleukin 12 (IL-12) pathway, which is a well-known player in the pathogenesis of systemic sclerosis (SSc). Therefore, we aimed to assess the possible role of this locus

  20. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress

    NARCIS (Netherlands)

    G.E. Hodes (Georgia E.); M.L. Pfau (Madeline L.); M. Leboeuf (Marylene); S.A. Golden (Sam A.); D.J. Christoffel (Daniel J.); D. Bregman (Dana); N. Rebusi (Nicole); M. Heshmati (Mitra); H. Aleyasin (Hossein); B.L. Warren (Brandon L.); B. Lebonté (Benoit); S. Horn (Sarah); K.A. Lapidus (Kyle A.); V. Stelzhammer (Viktoria); E.H.F. Wong (Erik H. F.); S. Bahn (Sabine); V. Krishnan (Vaishnav); C.A. Bolaños-Guzman (Carlos A.); J.W. Murrough (James W.); M. Merad (Miriam); S.J. Russo (Scott J.)

    2014-01-01

    textabstractDepression and anxiety disorders are associated with increased release of peripheral cytokines; however, their functional relevance remains unknown. Using a social stress model in mice, we find preexisting individual differences in the sensitivity of the peripheral immune system that

  1. Results of Use of WHO Global Salm-Surv External Quality Assurance System for Antimicrobial Susceptibility Testing of Salmonella Isolates from 2000 to 2007

    DEFF Research Database (Denmark)

    Hendriksen, Rene S.; Seyfarth, Anne Mette; Jensen, Arne Bent

    2009-01-01

    An international External Quality Assurance System (EQAS) for antimicrobial susceptibility testing of Salmonella was initiated in 2000 by the World Health Organization (WHO) Global Salm-Surv in order to enhance the capacities of national reference laboratories to obtain reliable data for surveill......An international External Quality Assurance System (EQAS) for antimicrobial susceptibility testing of Salmonella was initiated in 2000 by the World Health Organization (WHO) Global Salm-Surv in order to enhance the capacities of national reference laboratories to obtain reliable data...

  2. Susceptibility Imaging in Glial Tumor Grading; Using 3 Tesla Magnetic Resonance (MR) System and 32 Channel Head Coil.

    Science.gov (United States)

    Aydin, Omer; Buyukkaya, Ramazan; Hakyemez, Bahattin

    2017-01-01

    Susceptibility weighted imaging (SWI) is a velocity compensated, high-resolution three-dimensional (3D) spoiled gradient-echo sequence that uses magnitude and filtered-phase data. SWI seems to be a valuable tool for non-invasive evaluation of central nervous system gliomas. Relative cerebral blood volume (rCBV) ratio is one of the best noninvasive methods for glioma grading. Degree of intratumoral susceptibility signal (ITSS) on SWI correlates with rCBV ratio and histopathological grade. This study investigated the effectiveness of ITSS grading and rCBV ratio in preoperative assessment. Thirty-one patients (17 males and 14 females) with histopathogical diagnosis of glial tumor undergoing routine cranial MRI, SWI, and perfusion MRI examinations between October 2011 and July 2013 were retrospectively enrolled. All examinations were performed using 3T apparatus with 32-channel head coil. We used ITSS number for SWI grading. Correlations between SWI grade, rCBV ratio, and pathological grading were evaluated. ROC analysis was performed to determine the optimal rCBV ratio to distinguish between high-grade and low-grade glial tumors. There was a strong positive correlation between both pathological and SWI grading. We determined the optimal rCBV ratio to discriminate between high-grade and low-grade tumors to be 2.21. In conclusion, perfusion MRI and SWI using 3T MR and 32-channel head coil may provide useful information for preoperative glial tumor grading. SWI can be used as an accessory to perfusion MR technique in preoperative tumor grading.

  3. Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis.

    Science.gov (United States)

    Mattuzzi, Silvia; Barbi, Stefano; Carletto, Antonio; Ravagnani, Viviana; Moore, Patrick S; Bambara, Lisa Maria; Scarpa, Aldo

    2007-05-01

    To investigate possible associations of 9 single-nucleotide polymorphisms in the IL10, IL1B, IL1A, IL1RN, IL2, LTA, and IL6 genes with susceptibility to systemic sclerosis (SSc), and with clinical subtype of SSc patients. A total of 78 patients with SSc [diffuse SSc (dcSSc), n = 31; limited SSc, (lcSSc), n = 47] and 692 healthy blood donors were genotyped for the following polymorphisms: IL10 T-3575A, IL10 A-1082G, IL1B C-31T, IL1B C-511T, IL1A C-889T, IL1RN A9589T, IL2 T-384G, LTA T-91G, and IL6 G-174C. Alleles in IL1B-31 and IL1B-511 showed a significantly different distribution between cases and controls. Carriers of at least one copy of the IL1B-31-C allele had an increased risk of SSc [odds ratio (OR) 2.8, 95% confidence interval (CI) 1.6-5.2, p IL2-384-G allele were significantly more frequent among patients with lcSSc (80.8%), compared to patients with the diffuse subtype (45.1%) (OR 5.1, 95% CI 1.8-14.3, p = 0.001) and in subjects positive to anticentromere antibodies (OR 4.2, 95% CI 1.5-11.9, p = 0.007). Lastly, the distribution of the IL2-384 genotype showed statistically significant differences between controls and patients with lcSSc (OR 3.5, 95% CI 1.7-7.4, p IL2 gene polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of SSc.

  4. Systemic Inflammatory Responses and Lung Injury following Hip Fracture Surgery Increases Susceptibility to Infection in Aged Rats

    Directory of Open Access Journals (Sweden)

    Hao Zhang

    2013-01-01

    Full Text Available Pulmonary infections frequently occur following hip fracture surgery in aged patients. However, the underlying reasons are not fully understood. The present study investigates the systemic inflammatory response and pulmonary conditions following hip fracture surgery as a means of identifying risk factors for lung infections using an aged rodent model. Aged, male Sprague-Dawley rats (8 animals per group underwent a sham procedure or hip fracture plus femoral intramedullary pinning. Animals were sacrificed 1, 3, and 7 days after the injury. Markers of systemic inflammation and pulmonary injury were analyzed. Both sham-operated and injured/surgical group animals underwent intratracheal inoculation with Pseudomonas aeruginosa 1, 3, and 7 days after surgery. P. aeruginosa counts in blood and bronchoalveolar lavage (BAL fluid and survival rates were recorded. Serum TNF-α, IL-6, IL-1β, and IL-10 levels and markers of pulmonary injury were significantly increased at 1 and 3 days following hip fracture and surgery. Animals challenged with P. aeruginosa at 1 and 3 days after injury had a significantly decreased survival rate and more P. aeruginosa recovered from blood and BAL fluid. This study shows that hip fracture and surgery in aged rats induced a systemic inflammatory response and lung injury associated with increased susceptibility to infection during the acute phase after injury and surgery.

  5. Cigarette smoking and mechanisms of susceptibility to infections of the respiratory tract and other organ systems.

    Science.gov (United States)

    Feldman, Charles; Anderson, Ronald

    2013-09-01

    The predisposition of cigarette smokers for development of oral and respiratory infections caused by microbial pathogens is well recognised, with those infected with the human immunodeficiency virus (HIV) at particularly high risk. Smoking cigarettes has a suppressive effect on the protective functions of airway epithelium, alveolar macrophages, dendritic cells, natural killer (NK) cells and adaptive immune mechanisms, in the setting of chronic systemic activation of neutrophils. Cigarette smoke also has a direct effect on microbial pathogens to promote the likelihood of infective disease, specifically promotion of microbial virulence and antibiotic resistance. In addition to interactions between smoking and HIV infection, a number of specific infections/clinical syndromes have been associated epidemiologically with cigarette smoking, including those of the upper and lower respiratory tract, gastrointestinal tract, central nervous and other organ systems. Smoking cessation benefits patients in many ways, including reduction of the risk of infectious disease. Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  6. Susceptibility of South Korea to hydrologic extremes affecting the global food system

    Science.gov (United States)

    Puma, M. J.; Chon, S. Y.

    2015-12-01

    Food security in South Korea is closely linked to trade in the global food system. The country's production of major grains declined from 5.8 million metric tons (mmt) in 1998 to 4.8 mmt in 2014, which coincided with a shift in grain self sufficiency from 43% down to 24% over this same period. Many factors led to these changes, including reductions in domestic agricultural land, governmental policies supporting industry over agriculture, and a push towards trade liberalization. South Korea's self sufficiency is now one of the lowest among Organisation for Economic Co-operation and Development (OECD) countries, leaving it vulnerable to disruptions in the global food system. Here we explore this vulnerability by assessing how global trade disruptions would affect Korea's food security. We impose historical extreme drought and flood events that would possibly affect today's major food producing regions concurrently. Next we compute food supply deficits in South Korea that might result from these events. Our analyses provide a framework for formulating domestic food policies to enhance South Korea's food security in the increasingly fragile global food system.

  7. Coal log pipeline research at the University of Missouri

    Energy Technology Data Exchange (ETDEWEB)

    Liu, H.

    1992-03-01

    Project tasks: Perform the necessary testing and development to demonstrate that the amount of binder in coal logs can be reduced to 8% or lower to produce logs with adequate strength to eliminate breakage during pipeline transportation, under conditions experienced in long distance pipeline systems. Prior to conducting any testing and demonstration, grantee shall perform an information search and make full determination of all previous attempts to extrude or briquette coal, upon which the testing and demonstration shall be based. Perform the necessary development to demonstrate a small model of the most promising injection system for coal-logs, and test the logs produced from Task 1. Conduct economic analysis of coal-log pipeline, based upon the work to date. Refine and complete the economic model. Prepare a final report for DOE.

  8. Using Web Logs in the Science Classroom

    Science.gov (United States)

    Duplichan, Staycle C.

    2009-01-01

    As educators we must ask ourselves if we are meeting the needs of today's students. The science world is adapting to our ever-changing society; are the methodology and philosophy of our educational system keeping up? In this article, you'll learn why web logs (also called blogs) are an important Web 2.0 tool in your science classroom and how they…

  9. Gravitational Zoology: Fish as Model Systems for understanding Motion Sickness Susceptibility

    Science.gov (United States)

    Anken, R.; Rahmann, H.

    During the entire evolution of life on Earth, the development of all organisms took place under constant gravity conditions, against which they achieved specific countermeasures for compensation and adaptation. On this background, it is still an open question to which extent altered gravity such as hyper- or microgravity (centrifuge/spaceflight) affects the normal individual development, either on the systemic level of the whole organism or on the level of individual organs or even single cells. The present review provides information on this topic, focusing on the effects of altered gravity on developing fish as model systems even for higher vertebrates including humans, with special emphasis on the effect of altered gravity on behaviour and particularly on the developing brain and vestibular system. Overall, the results speak in favour of the following concept: Short -term altered gravity ( 1 day) can induce transitional aberrant behaviour due to malfunctions of the inner ear, originating from asymmetric otoliths or, generally, from a mismatch between canal and otolith afferents. The vanishing aberrant behaviour is due to a reweighing of sensory inputs and neurovestibular compensation, probably on bioelectrical basis. During long- term altered gravity (several days and more), step by step neuroplastic reactivities on molecular basis (i.e., molecular facilitation) in the brain and inner ears possibly activate feedback mechanisms between the CNS and the vestibular organs for the regain of normal behaviour. The following areas of research with animals at altered gravity need to be addressed in the future: 1. Maintenance of animals through two complete life cycles in the space environment (developmental deficiencies?). 2. Investigation of the peripheral and c ntral vestibular system by ground-based studiese (mutants, hypergravity experiments...), focusing on plasticity in developing animals as well as in adults. 3. Investigation of the effect of microgravity during

  10. Logística interna

    OpenAIRE

    Sousa, Paulo Teixeira de

    2002-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção. Essa dissertação tem como objetivo demonstrar a importância da logística interna nas organizações prestadoras de serviço. A logística é vista como um processo capaz de aumentar a eficiência organizacional através da redução dos custos operacionais bem como agiliza os processos de movimentação das mercadorias em toda cadeia de abastecimento. A logística é...

  11. Mud Logging; Control geologico en perforaciones petroliferas (Mud Logging)

    Energy Technology Data Exchange (ETDEWEB)

    Pumarega Lafuente, J.C.

    1994-12-31

    Mud Logging is an important activity in the oil field and it is a key job in drilling operations, our duties are the acquisition, collection and interpretation of the geological and engineering data at the wellsite, also inform the client immediately of any significant changes in the well. (Author)

  12. Acute Schistosoma mansoni infection increases susceptibility to systemic SHIV clade C infection in rhesus macaques after mucosal virus exposure.

    Directory of Open Access Journals (Sweden)

    Agnès-Laurence Chenine

    2008-07-01

    Full Text Available Individuals living in sub-Saharan Africa represent 10% of the world's population but almost 2/3 of all HIV-1/AIDS cases. The disproportionate HIV-1 infection rates in this region may be linked to helminthic parasite infections that affect many individuals in the developing world. However, the hypothesis that parasite infection increases an individual's susceptibility to HIV-1 has never been prospectively tested in a relevant in vivo model.We measured whether pre-existing infection of rhesus monkeys with a parasitic worm would facilitate systemic infection after mucosal AIDS virus exposure. Two groups of animals, one consisting of normal monkeys and the other harboring Schistosoma mansoni, were challenged intrarectally with decreasing doses of R5-tropic clade C simian-human immunodeficiency virus (SHIV-C. Systemic infection occurred in parasitized monkeys at viral doses that remained sub-infectious in normal hosts. In fact, the 50% animal infectious (AID(50 SHIV-C dose was 17-fold lower in parasitized animals compared to controls (P<0.001. Coinfected animals also had significantly higher peak viral RNA loads than controls (P<0.001, as well as increased viral replication in CD4(+ central memory cells (P = 0.03.Our data provide the first direct evidence that acute schistosomiasis significantly increases the risk of de novo AIDS virus acquisition, and the magnitude of the effect suggests that control of helminth infections may be a useful public health intervention to help decrease the spread of HIV-1.

  13. Ozonated water reduces susceptibility in tomato plants to Meloidogyne incognita by the modulation of the antioxidant system.

    Science.gov (United States)

    Veronico, Pasqua; Paciolla, Costantino; Sasanelli, Nicola; De Leonardis, Silvana; Melillo, Maria Teresa

    2017-05-01

    Few studies have been carried out on the effect of ozonated water (O3 wat) on the oxidative stress of root systems and, in particular, in combination with biotic stress. The aim of this study was to determine whether aqueous ozone is effective in the control of root-knot nematode (RKN) infection and to investigate the concomitant changes in the basal defence system. A tomato cultivar susceptible to Meloidogyne incognita was treated with O3 wat as a soil drench. No negative effects were seen following ozone application in comparison with the control under the exposure conditions used. The treatment reduced significantly the nematode infection rate and induced changes in the morphology of nematode feeding sites, some of which were characterized by visible symptoms of senescence. The antioxidant response, as well as parameters of oxidative damage, were examined in untreated and O3 wat-treated galls at 2, 4 and 7 days after inoculation and compared with uninfected roots. High levels of reactive oxygen species (ROS), H2 O2 and malondialdehyde were generated in galls in response to combined abiotic and biotic stresses. Throughout the experimental period, the activities and relative transcript levels of the antioxidant enzymes catalase, superoxide dismutase and ascorbate peroxidase produced different responses when exposed to ozone treatment and/or infection. The results demonstrate how O3 wat protects tomato against the RKN M. incognita through the modulation of basal defence mechanisms. © 2016 BSPP AND JOHN WILEY & SONS LTD.

  14. [Evaluation of the VITEK 2 system (AST-YSO1 cards) for antifungal susceptibility testing against different Candida species].

    Science.gov (United States)

    Ochiuzzi, María E; Arechavala, Alicia; Guelfand, Liliana; Maldonado, Ivana; Soloaga, Rolando

    2014-01-01

    The aim of this investigation was to evaluate the results of antifungal susceptibility for various Candida species using the Vitek 2 semi-automated system (AST-YSO1 cards, bioMérieux), and to compare them with those obtained by the CLSI (Clinical and Laboratory Standards Institute) broth microdilution reference method (Document M27-A3,2008). The essential agreement (EA) was > 90%, except for Candida glabrata against voriconazole (VCZ); and for Candida krusei against fluconazole (FCZ). The overall categorical agreement (CA) was > 90% when FCZ was evaluated and 89.5% at 24h and 80.7% at 48 h for VCZ. The average time for obtaining results was 15.5h. Minor errors were 7.8% at 24h and 6.1% at 48 h for FCZ, and 10.5% at 24h and 19.3% at 48 h for VCZ. There was only one very major error for FCZ against Candida parapsilosis and no major errors were observed. For amphotericin B, only three isolates showed MICs ≥ 2 μg/ml. The Vitek 2 system detected the MIC value for various Candida species and showed excellent agreement with the reference method proposed by the CLSI. Copyright © 2014 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  15. Association of interleukin-10 gene single nucleotide polymorphisms with susceptibility to systemic lupus erythematosus in a Chinese population.

    Science.gov (United States)

    Lv, Tian-Tian; Wu, Jun; Li, Jun; Zhang, Tian-Ping; Yang, Xiao-Ke; Xiang, Nan; Fan, Yin-Guang; Pan, Hai-Feng; Wang, Bin

    2018-02-05

    The aim of this study was to investigate the association of interleukin (IL)-10 gene single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese population. 848 SLE patients and 461 normal controls were recruited in this study. Nine SNPs in IL-10 gene (rs1518110, rs1518111, rs1554286, rs1800890, rs1800893, rs3024493, rs3024495, rs3024498 and rs6667202) were genotyped using TaqMan genotyping assays on Fluidigm 192.24 system. The frequency of IL-10 rs3024498-C allele was significantly higher in patient group compared with control subjects (OR=5.118, 95% CI=1.819-14.405, P=0.002). No significant differences were detected for the distribution of allele and genotype frequencies of other eight SNPs between patients with SLE and controls after Bonferroni correction (all P>0.0056). Interestingly, significant differences were detected both in the allele and genotype frequencies of rs3024498 between SLE patients with and without arthritis (P=0.002, P=0.022, respectively).There was significant difference in genotype frequency at rs3024498 between SLE patients with and without malar rash (P=0.040). And, there was significant difference in allele frequency at rs3024498 between SLE patients with and without anti-double-stranded DNA (P=0.032). Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively). There were significant difference in allele and genotype frequency at rs1800890 and rs6667202 between SLE patients with and without thrombocytopenia (rs1800890: P=0.016, P=0.026, respectively; rs6667202: P=0.007, P=0.007, respectively). Further, significant difference were observed both in allele frequency and in genotype distribution of rs1800893 between patients with and without tubular urine and proteinuria (tubular urine: PIL-10 rs3024498 polymorphism might contribute to SLE susceptibility and several clinical

  16. DBA2J db/db mice are susceptible to early albuminuria and glomerulosclerosis that correlate with systemic insulin resistance.

    Science.gov (United States)

    Østergaard, Mette V; Pinto, Vanda; Stevenson, Kirsty; Worm, Jesper; Fink, Lisbeth N; Coward, Richard J M

    2017-02-01

    Diabetic nephropathy (DN) is the leading cause of kidney failure in the world. To understand important mechanisms underlying this condition, and to develop new therapies, good animal models are required. In mouse models of type 1 diabetes, the DBA/2J strain has been shown to be more susceptible to develop kidney disease than other common strains. We hypothesized this would also be the case in type 2 diabetes. We studied db/db and wild-type (wt) DBA/2J mice and compared these with the db/db BLKS/J mouse, which is currently the most widely used type 2 DN model. Mice were analyzed from age 6 to 12 wk for systemic insulin resistance, albuminuria, and glomerular histopathological and ultrastructural changes. Body weight and nonfasted blood glucose were increased by 8 wk in both genders, while systemic insulin resistance commenced by 6 wk in female and 8 wk in male db/db DBA/2J mice. The urinary albumin-to-creatinine ratio (ACR) was closely linked to systemic insulin resistance in both sexes and was increased ~50-fold by 12 wk of age in the db/db DBA/2J cohort. Glomerulosclerosis, foot process effacement, and glomerular basement membrane thickening were observed at 12 wk of age in db/db DBA/2J mice. Compared with db/db BLKS/J mice, db/db DBA/2J mice had significantly increased levels of urinary ACR, but similar glomerular histopathological and ultrastructural changes. The db/db DBA/2J mouse is a robust model of early-stage albuminuric DN, and its levels of albuminuria correlate closely with systemic insulin resistance. This mouse model will be helpful in defining early mechanisms of DN and ultimately the development of novel therapies. Copyright © 2017 the American Physiological Society.

  17. Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 promotes systemic acquired resistance via azelaic acid and its precursor 9-oxo nonanoic acid.

    Science.gov (United States)

    Wittek, Finni; Hoffmann, Thomas; Kanawati, Basem; Bichlmeier, Marlies; Knappe, Claudia; Wenig, Marion; Schmitt-Kopplin, Philippe; Parker, Jane E; Schwab, Wilfried; Vlot, A Corina

    2014-11-01

    Systemic acquired resistance (SAR) is a form of inducible disease resistance that depends on salicylic acid and its upstream regulator ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1). Although local Arabidopsis thaliana defence responses activated by the Pseudomonas syringae effector protein AvrRpm1 are intact in eds1 mutant plants, SAR signal generation is abolished. Here, the SAR-specific phenotype of the eds1 mutant is utilized to identify metabolites that contribute to SAR. To this end, SAR bioassay-assisted fractionation of extracts from the wild type compared with eds1 mutant plants that conditionally express AvrRpm1 was performed. Using high-performance liquid chromatography followed by mass spectrometry, systemic immunity was associated with the accumulation of 60 metabolites, including the putative SAR signal azelaic acid (AzA) and its precursors 9-hydroperoxy octadecadienoic acid (9-HPOD) and 9-oxo nonanoic acid (ONA). Exogenous ONA induced SAR in systemic untreated leaves when applied at a 4-fold lower concentration than AzA. The data suggest that in planta oxidation of ONA to AzA might be partially responsible for this response and provide further evidence that AzA mobilizes Arabidopsis immunity in a concentration-dependent manner. The AzA fragmentation product pimelic acid did not induce SAR. The results link the C9 lipid peroxidation products ONA and AzA with systemic rather than local resistance and suggest that EDS1 directly or indirectly promotes the accumulation of ONA, AzA, or one or more of their common precursors possibly by activating one or more pathways that either result in the release of these compounds from galactolipids or promote lipid peroxidation. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  18. Extracting the Textual and Temporal Structure of Supercomputing Logs

    Energy Technology Data Exchange (ETDEWEB)

    Jain, S; Singh, I; Chandra, A; Zhang, Z; Bronevetsky, G

    2009-05-26

    Supercomputers are prone to frequent faults that adversely affect their performance, reliability and functionality. System logs collected on these systems are a valuable resource of information about their operational status and health. However, their massive size, complexity, and lack of standard format makes it difficult to automatically extract information that can be used to improve system management. In this work we propose a novel method to succinctly represent the contents of supercomputing logs, by using textual clustering to automatically find the syntactic structures of log messages. This information is used to automatically classify messages into semantic groups via an online clustering algorithm. Further, we describe a methodology for using the temporal proximity between groups of log messages to identify correlated events in the system. We apply our proposed methods to two large, publicly available supercomputing logs and show that our technique features nearly perfect accuracy for online log-classification and extracts meaningful structural and temporal message patterns that can be used to improve the accuracy of other log analysis techniques.

  19. Relationship between miR-146a rs2910164 (G>C) Polymorphism and Digestive System Cancer Susceptibility: A Meta-Analysis.

    Science.gov (United States)

    Xiong, Xin; Yan, Junfeng; Li, Linghua; Li, Yun; Cao, Yi; Tu, Yi; Mei, Jinhong

    2017-08-01

    MicroRNAs (miRNAs) are identified negatively regulating gene expression and acting as oncogenes or tumor suppressors in tumorigenesis. The association between miR-146a rs2910164 (G>C) polymorphism and susceptibility to digestive system cancers was contradictory and inconsistent in previously published studies. Presently, we performed a comprehensive literature retrieve on PubMed, Web of Science, Embase, Wanfang and CNKI databases to identify all relevant studies published before July 30, 2016. Odds ratio (OR) and 95% confidential interval (95%CI) were used to calculate the relationship between miR-146a rs2910164 (G>C) polymorphism and digestive system cancers susceptibility. Finally, a total of 45 publications comprising 47 separate case-control studies were enrolled in the present updated meta-analysis including 20,281 cases and 26,099 controls. However, no significant association was uncovered for miR-146a rs2910164 polymorphism and digestive system cancers susceptibility in all the genetic models. Moreover, in the stratification analyses by cancer type, the source of control, ethnicity and Hardy-Weinberg Equilibrium (HWE) status, we also revealed a negative result. To conclude, our work suggests that miR-146a rs2910164 (G>C) polymorphism is not a susceptibility factor for digestive system cancers. © 2017 by the Association of Clinical Scientists, Inc.

  20. Decomposable log-linear models

    DEFF Research Database (Denmark)

    Eriksen, Poul Svante

    can be characterized by a structured set of conditional independencies between some variables given some other variables. We term the new model class decomposable log-linear models, which is illustrated to be a much richer class than decomposable graphical models.It covers a wide range of non...

  1. What's new in well logging and formation evaluation

    Science.gov (United States)

    Prensky, S.

    2011-01-01

    A number of significant new developments is emerging in well logging and formation evaluation. Some of the new developments include an ultrasonic wireline imager, an electromagnetic free-point indicator, wired and fiber-optic coiled tubing systems, and extreme-temperature logging-while-drilling (LWD) tools. The continued consolidation of logging and petrophysical service providers in 2010 means that these innovations are increasingly being provided by a few large companies. Weatherford International has launched a slimhole cross-dipole tool as part of the company's line of compact logging tools. The 26-ft-long Compact Cross-Dipole Sonic (CXD) tool can be run as part of a quad-combo compact logging string. Halliburton has introduced a version of its circumferential acoustic scanning tool (CAST) that runs on monoconductor cable (CAST-M) to provide high-resolution images in open hole and in cased hole for casing and cement evaluation.

  2. WHO global salm-surv external quality assurance system (EQAS): an important step toward improving the quality of Salmonella serotyping and antimicrobial susceptibility testing worldwide

    DEFF Research Database (Denmark)

    Petersen, A.; Aarestrup, Frank Møller; Angulo, F. J.

    2002-01-01

    susceptibility testing through international training courses and an External Quality Assurance System (EQAS). In 2000, 44 WHO Global Salm-Surv member laboratories from 35 countries determined the serotype and antimicrobial susceptibility pattern for eight "blinded" Salmonella isolates. For serotyping, 73......% of the results were correct. For susceptibility testing, 92% of the results were in agreement with the expected results. However, only 78% of the performed tests with the E. coli ATCC 25922 reference strain were within the quality control range specified by National Committee for Clinical Laboratory Standards...... (NCCLS) guidelines. These EQAS results demonstrate the need for further training to improve the performance of some of the laboratories. WHO Global Salm-Surv activities, including international training courses and EQAS, represent an important step toward improving the quality of Salmonella serotyping...

  3. Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Tae-Ho Kim

    2016-01-01

    Full Text Available Osteonecrosis of the femoral head (ONFH is a complex and multifactorial disease that is influenced by a number of genetic factors in addition to environmental factors. Some autoimmune disorders, including systemic lupus erythematosus (SLE, rheumatoid arthritis (RA, and inflammatory bowel disease (IBD, are associated with the development of ONFH. Complement receptor type 2 (CR2 is membrane glycoprotein which binds C3 degradation products generated during complement activation. CR2 has many important functions in normal immunity and is assumed to play a role in the development of autoimmune disease. We investigated whether CR2 gene polymorphisms are associated with risk of ONFH in SLE patients. Eight polymorphisms in the CR2 gene were genotyped using TaqMan™ assays in 150 SLE patients and 50 ONFH in SLE patients (SLE_ONFH. The association analysis of genotyped SNPs and haplotypes was performed with ONFH. It was found that three SNPs, rs3813946 in 5′-UTR (untranslated region, rs311306 in intron 1, and rs17615 in exon 10 (nonsynonymous SNP; G/A, Ser639Asn of the CR2 gene, were associated with an increased risk of ONFH under recessive model (P values; 0.004~0.016. Haplotypes were also associated with an increased risk (OR; 3.73~ of ONFH in SLE patients. These findings may provide evidences that CR2 contributes to human ONFH susceptibility in Korean SLE patients.

  4. KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor

    Science.gov (United States)

    2012-01-01

    Introduction Potassium voltage-gated channel shaker-related subfamily member 5 (KCNA5) is implicated in vascular tone regulation, and its inhibition during hypoxia produces pulmonary vasoconstriction. Recently, a protective association of the KCNA5 locus with systemic sclerosis (SSc) patients with pulmonary arterial hypertension (PAH) was reported. Hence, the aim of this study was to replicate these findings in an independent multicenter Caucasian SSc cohort. Methods The 2,343 SSc cases (179 PAH positive, confirmed by right-heart catheterization) and 2,690 matched healthy controls from five European countries were included in this study. Rs10744676 single-nucleotide polymorphism (SNP) was genotyped by using a TaqMan SNP genotyping assay. Results Individual population analyses of the selected KCNA5 genetic variant did not show significant association with SSc or any of the defined subsets (for example, limited cutaneous SSc, diffuse cutaneous SSc, anti-centromere autoantibody positive and anti-topoisomerase autoantibody positive). Furthermore, pooled analyses revealed no significant evidence of association with the disease or any of the subsets, not even the PAH-positive group. The comparison of PAH-positive patients with PAH-negative patients showed no significant differences among patients. Conclusions Our data do not support an important role of KCNA5 as an SSc-susceptibility factor or as a PAH-development genetic marker for SSc patients. PMID:23270786

  5. Role of genetic heterogeneity and epistasis in bladder cancer susceptibility and outcome: a learning classifier system approach.

    Science.gov (United States)

    Urbanowicz, Ryan John; Andrew, Angeline S; Karagas, Margaret Rita; Moore, Jason H

    2013-01-01

    Detecting complex patterns of association between genetic or environmental risk factors and disease risk has become an important target for epidemiological research. In particular, strategies that provide multifactor interactions or heterogeneous patterns of association can offer new insights into association studies for which traditional analytic tools have had limited success. To concurrently examine these phenomena, previous work has successfully considered the application of learning classifier systems (LCSs), a flexible class of evolutionary algorithms that distributes learned associations over a population of rules. Subsequent work dealt with the inherent problems of knowledge discovery and interpretation within these algorithms, allowing for the characterization of heterogeneous patterns of association. Whereas these previous advancements were evaluated using complex simulation studies, this study applied these collective works to a 'real-world' genetic epidemiology study of bladder cancer susceptibility. We replicated the identification of previously characterized factors that modify bladder cancer risk--namely, single nucleotide polymorphisms from a DNA repair gene, and smoking. Furthermore, we identified potentially heterogeneous groups of subjects characterized by distinct patterns of association. Cox proportional hazard models comparing clinical outcome variables between the cases of the two largest groups yielded a significant, meaningful difference in survival time in years (survivorship). A marginally significant difference in recurrence time was also noted. These results support the hypothesis that an LCS approach can offer greater insight into complex patterns of association. This methodology appears to be well suited to the dissection of disease heterogeneity, a key component in the advancement of personalized medicine.

  6. A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications.

    Science.gov (United States)

    Conserva, Francesca; Gesualdo, Loreto; Papale, Massimo

    2016-01-01

    Diabetic nephropathy (DN), a microvascular complication occurring in approximately 20-40% of patients with type 2 diabetes mellitus (T2DM), is characterized by the progressive impairment of glomerular filtration and the development of Kimmelstiel-Wilson lesions leading to end-stage renal failure (ESRD). The causes and molecular mechanisms mediating the onset of T2DM chronic complications are yet sketchy and it is not clear why disease progression occurs only in some patients. We performed a systematic analysis of the most relevant studies investigating genetic susceptibility and specific transcriptomic, epigenetic, proteomic, and metabolomic patterns in order to summarize the most significant traits associated with the disease onset and progression. The picture that emerges is complex and fascinating as it includes the regulation/dysregulation of numerous biological processes, converging toward the activation of inflammatory processes, oxidative stress, remodeling of cellular function and morphology, and disturbance of metabolic pathways. The growing interest in the characterization of protein post-translational modifications and the importance of handling large datasets using a systems biology approach are also discussed.

  7. Hardwood log supply: a broader perspective

    Science.gov (United States)

    Iris Montague; Adri Andersch; Jan Wiedenbeck; Urs. Buehlmann

    2015-01-01

    At regional and state meetings we talk with others in our business about the problems we face: log exports, log quality, log markets, logger shortages, cash flow problems, the weather. These are familiar talking points and real and persistent problems. But what is the relative importance of these problems for log procurement in different regions of...

  8. Nondestructive evaluation for sorting red maple logs

    Science.gov (United States)

    Xiping Wang; Robert J. Ross; David W. Green; Karl Englund; Michael Wolcott

    2000-01-01

    Existing log grading procedures in the United States make only visual assessments of log quality. These procedures do not incorporate estimates of the modulus of elasticity (MOE) of logs. It is questionable whether the visual grading procedures currently used for logs adequately assess the potential quality of structural products manufactured from them, especially...

  9. When is hardwood cable logging economical?

    Science.gov (United States)

    Chris B. LeDoux

    1985-01-01

    Using cable logging to harvest eastern hardwood logs on steep terrain can result in low production rates and high costs per unit of wood produced. Logging managers can improve productivity and profitability by knowing how the interaction of site-specific variables and cable logging equipment affect costs and revenues. Data from selected field studies and forest model...

  10. Quantifying the Effect of 3T Magnetic Resonance Imaging Residual System Distortions and Patient-Induced Susceptibility Distortions on Radiation Therapy Treatment Planning for Prostate Cancer.

    Science.gov (United States)

    Adjeiwaah, Mary; Bylund, Mikael; Lundman, Josef A; Karlsson, Camilla Thellenberg; Jonsson, Joakim H; Nyholm, Tufve

    2017-10-20

    To investigate the effect of magnetic resonance system- and patient-induced susceptibility distortions from a 3T scanner on dose distributions for prostate cancers. Combined displacement fields from the residual system and patient-induced susceptibility distortions were used to distort 17 prostate patient CT images. VMAT dose plans were initially optimized on distorted CT images and the plan parameters transferred to the original patient CT images to calculate a new dose distribution. Maximum residual mean distortions of 3.19 mm at a radial distance of 25 cm and maximum mean patient-induced susceptibility shifts of 5.8 mm were found using the lowest bandwidth of 122 Hz per pixel. There was a dose difference of resonance scanners are larger than residual system distortions after using vendor-supplied 3-dimensional correction for the delineated regions studied. However, errors in dose due to disturbed patient outline and shifts caused by patient-induced susceptibility effects are below 0.5%. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  11. Magnetic Logs from the Lopra-1/1A and Vestmanna-1 wells (Faroe Islands)

    DEFF Research Database (Denmark)

    Waagstein, R.; Abrahamsen, N.

    2006-01-01

      Susceptibility results from cores (representing basalt, lapilli-tuffs and tuffs) and magnetic logs from the Lopra-1/1A well are presented. The basalts fall into a high- and a low-susceptibility group with no overlap. The high-susceptibility basalts (7 cores) have susceptibilities between 4 and ...... of the lower basalt formation correlates with Chrons C26n, C25r and C25n and the more than 2.3 km thick middle and upper basalt formations correlate with Chron C24n.3r....

  12. Logística empresarial

    Directory of Open Access Journals (Sweden)

    Feres Sahid

    1987-04-01

    Full Text Available RESUMEN El concepto logístico, se pudo ver reflejado con exactitud desde el punto de vista etimológico e histórico a través de la revista de la E.A.N; ya que  tiene cierto carácter militar que lo hace característico a la gestión empresarial y de esto se formula un debate definitivo de este concepto.

  13. Chemical logging of geothermal wells

    Science.gov (United States)

    Allen, C.A.; McAtee, R.E.

    The presence of geothermal aquifers can be detected while drilling in geothermal formations by maintaining a chemical log of the ratio of the concentrations of calcium to carbonate and bicarbonate ions in the return drilling fluid. A continuous increase in the ratio of the concentrations of calcium to carbonate and bicarbonate ions is indicative of the existence of a warm or hot geothermal aquifer at some increased depth.

  14. Mining access logs with predictive analytics to improve student performance

    OpenAIRE

    Corrigan, Owen; Glynn, Mark; Smeaton, Alan F.; Smyth, Sinead

    2015-01-01

    Access log files are an important part of the development of computing, developed to keep a record of what has been happening in a system so that it can be subsequently searched as part of debugging or error-fixing. That’s how access logs started, mostly used as some form of record for forensic investigation and not much value beyond that. With the advent of new techniques for data analytics, however, access log files are suddenly becoming quite valuable when they are mined, as opposed to sea...

  15. A methodological approach to assess beach-dune system susceptibility to erosion. Cases studies from Valdelagrana spit (Spain) and Campomarino beach (Italy).

    Science.gov (United States)

    Rizzo, Angela; Aucelli, Pietro P. C.; Gracia, Javier F.; Anfuso, Giorgio; Rosskopf, Carmen M.

    2016-04-01

    Dunes provide many important services to coastal areas, such as coastal erosion mitigation, coastal flooding protection and biological diversity. Their dynamic equilibrium and geomorphological evolution are the result of the interaction between marine and aeolian processes. Moreover, coastal dunes are characterized by a high ecological value, being a narrow strip between marine and terrestrial ecosystems and are habitats considered of community interest by the Habitats Directive 92/43/EEC. In the meantime, the significant increase of human pressure on coastal environments during the last decades has caused a strong alteration and an increase of the fragility and fragmentation of these habitats. This paper presents a methodological approach for the assessment of the beach-dune system susceptibility to erosion. The aim is to identify, at the local scale, the degree of susceptibility of coastal stretches in order to evaluate the degree of exposure of human settlements and natural environments located behind the dune system and to support actuations to appropriately improve dune management and conservation. A coastal susceptibility matrix and a corresponding Coastal Susceptibility Index (CSI) are proposed. Following the assumption that a good index should be based on a minimum amount of essential information (Cooper and McLaughlin, 1998), possibly already available or easy to be obtained (Villa and McLeod, 2002), the proposed index consisted into eight variables concerning existing beach and dune conditions, covering geomorphological, physical and anthropogenic aspects. Each variable was inserted into a GIS system and overlapped with the others through a logical overlay operation. The resulting layer was reclassified according to the formula proposed by Rangel and Anfuso (2015) allowing to calculate the CSI, which ranged from 1 (null/very low susceptibility) to 5 (very high susceptibility). In a further step, the predominant processes occurred in the last decades were

  16. Accurately determining log and bark volumes of saw logs using high-resolution laser scan data

    Science.gov (United States)

    R. Edward Thomas; Neal D. Bennett

    2014-01-01

    Accurately determining the volume of logs and bark is crucial to estimating the total expected value recovery from a log. Knowing the correct size and volume of a log helps to determine which processing method, if any, should be used on a given log. However, applying volume estimation methods consistently can be difficult. Errors in log measurement and oddly shaped...

  17. AUTOMATED TECHNIQUE FOR CREATING LITHOLOGIC LOG PLOTS

    Directory of Open Access Journals (Sweden)

    Kristijan Posavec

    2006-12-01

    Full Text Available Paper presents automated technique for creating lithologic log plots. Technique is based on three computer tools: Microsoft (MS Access program, LogPlot program, and Visual Basic (VB macros for MS Excel. MS Access ensures professional storage of lithologic data which can be in that way easier and faster entered, searched, updated, and also used for different purposes, while LogPlot provides tools for creating lithologic log plots. VB macros enable transfer of lithologic data from MS Access to LogPlot. Data stored in MS Access are exported in ASCII files which are later used by LogPlot for creation of lithologic log plots. Presented concept facilitates creation of lithologic log plots, and automated technique enables processing of a large number of data i.e. creation of lareg number lithologic log plots in a short period of time (the paper is published in Croatian.

  18. Coal log pipeline research at the University of Missouri. 1st Quarterly report for 1995, January 1, 1995--March 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Liu, H.

    1995-08-01

    Work continued on the study of coal log pipeline research. Individual projects described include fast compaction of coal logs; effect of cooling on coal log quality; coal log capping; effectiveness of adding fiber to enhance coal log quality; fabrication using hydrophobic binders; cost estimation of different lubricants; automatic control of coal log pipeline system; CLP design; coal log train transport; economics of coal log pipeline; legal aspects; heating, cooling, and drying of logs; vacuum systems to enhance production; design; and effect of piston modification on capping.

  19. Coal log pipeline research at University of Missouri. 1. quarterly report for 1996, January 1--March 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    This project consists of the following nine tasks: Machine design for coal log fabrication; Very rapid compaction of coal logs; Rapid compaction of coal logs; Fast-track experiments on coal log compaction; Coal log fabrication using hydrophobic binders; Drag reduction in large diameter hydraulic capsule pipeline; Automatic control of coal log pipeline system; Hydraulics of CLP (Coal Log Pipeline); and Coal heating system research. The purpose of the task, the work accomplished during this report period, and work proposed for the next quarter are described for each task.

  20. Comparison of the Vitek 2 yeast susceptibility system with CLSI microdilution for antifungal susceptibility testing of fluconazole and voriconazole against Candida spp., using new clinical breakpoints and epidemiological cutoff values.

    Science.gov (United States)

    Pfaller, Michael A; Diekema, Daniel J; Procop, Gary W; Rinaldi, Michael G

    2013-09-01

    A commercially available, fully automated yeast susceptibility test system (Vitek 2; bioMérieux, Marcy d'Etoile, France) was compared in 3 different laboratories with the Clinical and Laboratory Standards Institute (CLSI) reference microdilution (BMD) method by testing 2 quality control strains, 10 reproducibility strains, and 425 isolates of Candida spp. against fluconazole and voriconazole. Reference CLSI BMD MIC endpoints and Vitek 2 MIC endpoints were read after 24 hours and 9.1-27.1 hours incubation, respectively. Excellent essential agreement (within 2 dilutions) between the reference and Vitek 2 MICs was observed for fluconazole (97.9%) and voriconazole (96.7%). Categorical agreement (CA) between the 2 methods was assessed using the new species-specific clinical breakpoints (CBPs): susceptible (S) ≤2 μg/mL, susceptible dose-dependent (SDD) 4 μg/mL, and resistant (R) ≥8 μg/mL for fluconazole and Candida albicans, Candida tropicalis, and Candida parapsilosis and ≤32 μg/mL (SDD), ≥64 μg/mL (R) for Candida glabrata; S ≤0.12 μg/mL, SDD 0.25-0.5 μg/mL, R ≥1 μg/mL for voriconazole and C. albicans, C. tropicalis, and C. parapsilosis, and ≤0.5 μg/mL (S), 1 μg/mL (SDD), ≥2 μg/mL (R) for Candida krusei. The epidemiological cutoff value (ECV) of 0.5 μg/mL for voriconazole and C. glabrata was used to differentiate wild-type (WT; MIC ≤ ECV) from non-WT (MIC > ECV) strains of this species. Due to the lack of CBPs for the less common species, the ECVs for fluconazole and voriconazole, respectively, were used for Candida lusitaniae (2 μg/mL and 0.03 μg/mL), Candida dubliniensis (0.5 μg/mL and 0.03 μg/mL), Candida guilliermondii (8 μg/mL and 0.25 μg/mL), and Candida pelliculosa (4 μg/mL and 0.25 μg/mL) to categorize isolates of these species as WT and non-WT. CA between the 2 methods was 96.8% for fluconazole and 96.5% for voriconazole with less than 1% very major errors and 1.3-3.0% major errors. The Vitek 2 yeast susceptibility system

  1. Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity

    OpenAIRE

    Robinson, Mike JF; Burghardt, Paul R; Patterson, Christa M.; Nobile, Cameron W; Akil, Huda; Watson, Stanley J.; Berridge, Kent C.; Ferrario, Carrie R.

    2015-01-01

    Pavlovian cues associated with junk-foods (caloric, highly sweet, and/or fatty foods), like the smell of brownies, can elicit craving to eat and increase the amount of food consumed. People who are more susceptible to these motivational effects of food cues may have a higher risk for becoming obese. Further, overconsumption of junk-foods leading to the development of obesity may itself heighten attraction to food cues. Here, we used a model of individual susceptibility to junk-foods diet-indu...

  2. Spatial prediction of landslide susceptibility using an adaptive neuro-fuzzy inference system combined with frequency ratio, generalized additive model, and support vector machine techniques

    Science.gov (United States)

    Chen, Wei; Pourghasemi, Hamid Reza; Panahi, Mahdi; Kornejady, Aiding; Wang, Jiale; Xie, Xiaoshen; Cao, Shubo

    2017-11-01

    The spatial prediction of landslide susceptibility is an important prerequisite for the analysis of landslide hazards and risks in any area. This research uses three data mining techniques, such as an adaptive neuro-fuzzy inference system combined with frequency ratio (ANFIS-FR), a generalized additive model (GAM), and a support vector machine (SVM), for landslide susceptibility mapping in Hanyuan County, China. In the first step, in accordance with a review of the previous literature, twelve conditioning factors, including slope aspect, altitude, slope angle, topographic wetness index (TWI), plan curvature, profile curvature, distance to rivers, distance to faults, distance to roads, land use, normalized difference vegetation index (NDVI), and lithology, were selected. In the second step, a collinearity test and correlation analysis between the conditioning factors and landslides were applied. In the third step, we used three advanced methods, namely, ANFIS-FR, GAM, and SVM, for landslide susceptibility modeling. Subsequently, the results of their accuracy were validated using a receiver operating characteristic curve. The results showed that all three models have good prediction capabilities, while the SVM model has the highest prediction rate of 0.875, followed by the ANFIS-FR and GAM models with prediction rates of 0.851 and 0.846, respectively. Thus, the landslide susceptibility maps produced in the study area can be applied for management of hazards and risks in landslide-prone Hanyuan County.

  3. Os benefícios da utilização do Sistema Warehouse Management System na cadeia de logística reversa no Brasil

    Directory of Open Access Journals (Sweden)

    Agostinho Augusto Figueira

    2017-01-01

    Full Text Available The marked growth and use of direct sales by companies, through e-commerce, has driven an increase in sales, leading to increasing volumes of warehoused products in the aim of creating agility in the delivery to final customers. However, there are problems in managing these items on a wide scale, which requires the use of specific management systems that are not yet easily found. In this article, we discuss the implementation and use of reverse supply-chain management systems to meet the growing demand for products, including reverse logistics. A descriptive bibliographical study was carried out, based on collected theoretical references, such as books, articles, and specific manuals. Through a hypothetical-deductive analysis, the objective was to identify possibilities, importance, and scope of the topic in order to contribute to the improvement of the area of logistics. It was observed that the adaptation of traditional warehouse storage systems to WMS, used in direct logistics, has also been adopted for reverse logistics. This system made it possible to increase the productivity and the recycling of waste in the logistics chain, as well as to reduce the direct and indirect costs of this process.

  4. Antimicrobial susceptibility of Escherichia coli F4, Pasteurella multocida, and Streptococcus suis isolates from a diagnostic veterinary laboratory and recommendations for a surveillance system.

    Science.gov (United States)

    Glass-Kaastra, Shiona K; Pearl, David L; Reid-Smith, Richard J; McEwen, Beverly; Slavic, Durda; McEwen, Scott A; Fairles, Jim

    2014-04-01

    Antimicrobial susceptibility data on Escherichia coli F4, Pasteurella multocida, and Streptococcus suis isolates from Ontario swine (January 1998 to October 2010) were acquired from a comprehensive diagnostic veterinary laboratory in Ontario, Canada. In relation to the possible development of a surveillance system for antimicrobial resistance, data were assessed for ease of management, completeness, consistency, and applicability for temporal and spatial statistical analyses. Limited farm location data precluded spatial analyses and missing demographic data limited their use as predictors within multivariable statistical models. Changes in the standard panel of antimicrobials used for susceptibility testing reduced the number of antimicrobials available for temporal analyses. Data consistency and quality could improve over time in this and similar diagnostic laboratory settings by encouraging complete reporting with sample submission and by modifying database systems to limit free-text data entry. These changes could make more statistical methods available for disease surveillance and cluster detection.

  5. Summarizing clinical pathways from event logs.

    Science.gov (United States)

    Huang, Zhengxing; Lu, Xudong; Duan, Huilong; Fan, Wu

    2013-02-01

    Clinical pathway analysis, as a pivotal issue in ensuring specialized, standardized, normalized and sophisticated therapy procedures, is receiving increasing attention in the field of medical informatics. Research in clinical pathway analysis has so far mostly focused on looking at aggregated data seen from an external perspective, and only provide very limited insight into the pathways. In some recent work, process mining techniques have been studied in discovering clinical pathway models from data. While it is interesting, discovered models may provide too much detail to give a comprehensive summary of the pathway. Moreover, the number of patterns discovered can be large. Alternatively, this article presents a new approach to build a concise and comprehensive summary that describes the entire structure of a clinical pathway, while revealing essential/critical medical behaviors in specific time intervals over the whole time period of the pathway. The presented approach summarizes a clinical pathway from the collected clinical event log, which regularly records all kinds of patient therapy and treatment activities in clinical workflow by various hospital information systems. The proposed approach formally defines the clinical pathway summarization problem as an optimization problem that can be solved in polynomial time by using a dynamic-programming algorithm. More specifically, given an input event log, the presented approach summarizes the pathway by segmenting the observed time period of the pathway into continuous and overlapping time intervals, and discovering frequent medical behavior patterns in each specific time interval from the log. The proposed approach is evaluated via real-world data-sets, which are extracted from Zhejiang Huzhou Central hospital of China with regard to four specific diseases, i.e., bronchial lung cancer, colon cancer, gastric cancer, and cerebral infarction, in two years (2007.08-2009.09). Although the medical behaviors contained in

  6. Logística empresarial

    OpenAIRE

    Carro, Roberto; González Gómez, Daniel A.

    2013-01-01

    El éxito de una empresa, creada para ofrecer productos en el mercado, depende en gran medida de que pueda lograr una conjunción razonable de la cantidad, calidad, oportunidad y el costo de los bienes y servicios que produce. Cuando se habla de oportunidad en el aprovisionamiento y la entrega, lo que se considera en realidad es la tarea que ha de desarrollar la empresa para satisfacer, rentablemente, las necesidades de producción y de los clientes en el momento adecuado. El cometido de la logí...

  7. Data Mining of Network Logs

    Science.gov (United States)

    Collazo, Carlimar

    2011-01-01

    The statement of purpose is to analyze network monitoring logs to support the computer incident response team. Specifically, gain a clear understanding of the Uniform Resource Locator (URL) and its structure, and provide a way to breakdown a URL based on protocol, host name domain name, path, and other attributes. Finally, provide a method to perform data reduction by identifying the different types of advertisements shown on a webpage for incident data analysis. The procedures used for analysis and data reduction will be a computer program which would analyze the URL and identify and advertisement links from the actual content links.

  8. Os benefícios da utilização do Sistema Warehouse Management System na cadeia de logística reversa no Brasil

    OpenAIRE

    Agostinho Augusto Figueira; Marcos Roberto Buri

    2017-01-01

    The marked growth and use of direct sales by companies, through e-commerce, has driven an increase in sales, leading to increasing volumes of warehoused products in the aim of creating agility in the delivery to final customers. However, there are problems in managing these items on a wide scale, which requires the use of specific management systems that are not yet easily found. In this article, we discuss the implementation and use of reverse...

  9. Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus.

    Science.gov (United States)

    Demirci, F Yesim; Wang, Xingbin; Morris, David L; Feingold, Eleanor; Bernatsky, Sasha; Pineau, Christian; Clarke, Ann; Ramsey-Goldman, Rosalind; Manzi, Susan; Vyse, Timothy J; Kamboh, M I

    2017-06-01

    A major systemic lupus erythematosus (SLE) susceptibility locus lies within a common inversion polymorphism region (encompassing 3.8 - 4.5  Mb) located at 8p23. Initially implicated genes included FAM167A-BLK and XKR6, of which BLK received major attention due to its known role in B-cell biology. Recently, additional SLE risk carried in non-inverted background was also reported. In this case -control study, we further investigated the 'extended' 8p23 locus (~ 4  Mb) where we observed multiple SLE signals and assessed these signals for their relation to the inversion affecting this region. The study involved a North American discovery data set (~ 1200  subjects) and a replication data set (> 10 000  subjects) comprising European-descent individuals. Meta-analysis of 8p23 SNPs, with p data sets, identified 51 genome-wide significant SNPs (p signals (XKR6-FAM167A-BLK subregion), our results also revealed two 'new' SLE signals, including SGK223-CLDN23-MFHAS1 (6.06 × 10-9 ≤ meta p ≤ 4.88 × 10-8) and CTSB (meta p = 4.87 × 10-8) subregions that are located > 2 Mb upstream and ~ 0.3  Mb downstream from previously reported signals. Functional assessment of relevant SNPs indicated putative cis-effects on the expression of various genes at 8p23. Additional analyses in discovery sample, where the inversion genotypes were inferred, replicated the association of non-inverted status with SLE risk and suggested that a number of SLE risk alleles are predominantly carried in non-inverted background. Our results implicate multiple (known+novel) SLE signals/genes at the extended 8p23 locus, beyond previously reported signals/genes, and suggest that this broad locus contributes to SLE risk through the effects of multiple genes/pathways. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  10. Selective logging in the Brazilian Amazon.

    Science.gov (United States)

    G. P. Asner; D. E. Knapp; E. N. Broadbent; P. J. C. Oliveira; M Keller; J. N. Silva

    2005-01-01

    Amazon deforestation has been measured by remote sensing for three decades. In comparison, selective logging has been mostly invisible to satellites. We developed a large-scale, high-resolution, automated remote-sensing analysis of selective logging in the top five timber-producing states of the Brazilian Amazon. Logged areas ranged from 12,075 to 19,823 square...

  11. Selective logging and its relation to deforestation

    Science.gov (United States)

    Gregory P. Asner; Michael Keller; Marco Lentini; Frank Merry; Souza Jr. Carlos

    2009-01-01

    Selective logging is a major contributor to the social, economic, and ecological dynamics of Brazilian Amazonia. Logging activities have expanded from low-volume floodplain harvests in past centuries to high-volume operations today that take about 25 million m3 of wood from the forest each year. The most common high-impact conventional and often illegal logging...

  12. Hardwood log grading scale stick improved

    Science.gov (United States)

    M. D. Ostrander; G. H. Englerth

    1953-01-01

    In February 1952 the Northeastern Forest Experiment Station described ( Research Note 13) a new log-grading scale stick developed by the Station for use as a visual aid in grading hardwood factory logs. It was based on the U. S. Forest Products Laboratory's log-grade specifications.

  13. Pacific Rim log trade: determinants and trends.

    Science.gov (United States)

    Donald F. Flora; Andrea L. Anderson; Wendy J. McGinnls

    1991-01-01

    Pacific Rim trade in softwood logs amounts to about $3 billion annually, of which the U.S. share is about $2 billion. Log exporting is a significant part of the forest economy in the Pacific Northwest. The 10 major Pacific Rim log-trading client and competitor countries differ widely in their roles in trade and in their policies affecting the industry.

  14. Effect of antimicrobial peptides on colistin-susceptible and colistin-resistant strains of Klebsiella pneumoniae and Enterobacter asburiae.

    Science.gov (United States)

    Kádár, Béla; Kocsis, Béla; Kristof, Katalin; Tóth, Ákos; Szabó, Dóra

    2015-12-01

    In this study susceptibility to different antimicrobial peptides was investigated on colistin-susceptible and colistin-resistant identical pulsotype strains of KPC-2 producing Klebsiella pneumoniae ST258 as well as colistin-susceptible and colistin-resistant Enterobacter asburiae strains isolated from clinical samples. In our test, bacteria were exposed to 50 mg/ml lactoferrin, lysozyme and protamine - cationic antimicrobial peptides belonging to innate immune system and having structural similarity to polymyxins - in separate reactions. After 18 hours incubation of colonies were counted. 40% of colistin-resistant K. pneumoniae strains and 97% of colistin-susceptible counterpart strains were lysed by protamine whereas 87% and 100% colony forming unit decrease by lysozyme was seen, respectively. In the case of colistin-resistant E. asburiae strains 1 log10 cell count increase were observed after treatment with lysozyme and 1.56 log10 after lactoferrin exposure compared to the initial number whereas the colistin-susceptible showed no relevant cell count increase. Our findings suggest that acquired colistin-resistance in Enterobacteriaceae is associated with tolerance against antimicrobial peptides.

  15. Static dictionaries on AC0 RAMs: query time (√log n/log log n) is necessary and sufficient

    DEFF Research Database (Denmark)

    Andersson, Arne; Miltersen, Peter Bro; Riis, Søren

    1996-01-01

    In this paper we consider solutions to the static dictionary problem on AC0 RAMs, i.e. random access machines where the only restriction on the finite instruction set is that all computational instructions are in AC0. Our main result is a tight upper and lower bound of θ(√log n/log log n......, we show a tradeoff between time and circuit depth under the unit-cost assumption: any RAM instruction set which permits a linear space, constant query time solution to the static dictionary problem must have an instruction of depth Ω(log w/log log to), where w is the word size of the machine (and log...

  16. Quality control for quantitative geophysical logging

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Kyu; Hwang, Se Ho; Hwang, Hak Soo; Park, In Hwa [Korea Institute of Geology Mining and Materials, Taejon (Korea)

    1998-12-01

    Despite the great availability of geophysical data obtained from boreholes, the interpretation is subject to significant uncertainties. More accurate data with less statistical uncertainties should require an employment of more quantitative techniques in log acquisition and interpretation technique. The long-term objective of this project is the development of techniques in both quality control of log measurement and the quantitative interpretation. In the first year, the goals of the project will include establishing the procedure of log acquisition using various tests, analysing the effect of logging velocity change on the logging data, examining the repeatability and reproducibility, analyzing of filtering effect on the log measurements, and finally the zonation and the correlation of single-and inter-well log data. For the establishment of logging procedure, we have tested the multiple factors affecting the accuracy in depth. The factors are divided into two parts: human and mechanical. These factors include the zero setting of depth, the calculation of offset for the sonde, the stretching effect of cable, and measuring wheel accuracy. We conclude that the error in depth setting results primarily from human factor, and also in part from the stretching of cable. The statistical fluctuation of log measurements increases according to increasing the logging speed for the zone of lower natural gamma. Thus, the problem related with logging speed is a trifling matter in case of the application of resources exploration, the logging speed should run more slowly to reduce the statistical fluctuation of natural gamma with lithologic correlation in mind. The repeatability and reproducibility of logging measurements are tested. The results of repeatability test for the natural gamma sonde are qualitatively acceptable in the reproducibility test, the errors occurs in logging data between two operators and successive trials. We conclude that the errors result from the

  17. Accurate characterization of ofloxacin susceptibility with Enterobacteriaceae using a modified GNS F6 card and the bioMerieux Vitek System.

    Science.gov (United States)

    Doern, G V; Torres, B B; Jankins, M; Jones, R N

    1996-07-01

    Routine antimicrobial susceptibility testing of Enterobacteriaceae using the Vitek System (bioMerieux Vitek, Hazelwood, MO) and the GNS-F6 card revealed discrepancies between the activity of ofloxacin and ciprofloxacin, primarily with isolates of Klebsiella pneumoniae. Specifically, during a one-year period, 12% of 618 ciprofloxacin-susceptible isolates were determined to be ofloxacin resistant with the GNS-F6 card. A similar problem, but one of lower magnitude, was observed with Serratia marsescens. That these represented false ofloxacin resistance results was confirmed by comparison of broth microdilution determinations of ofloxacin MICs with F6 results on a collection of 203 fresh clinical isolates of K. pneumoniae and 39 isolates of S. marsescens. The GNS-F6 card was then modified by the manufacturer to include a new formulation of ofloxacin and assessed using a collection of 224 recent clinical isolates of Enterobacteriaceae and Pseudomonas aeruginosa, and 78 stock cultures of enteric Gram-negative bacilli selected specifically because of disproportionately high rates of fluoroquinolone resistance. No ofloxacin false resistant results were observed with this collection when the modified GNS-F6 card was evaluated in comparison to a standardized broth microdilution MIC test. The current clinical version of the Vitek System appears to accurately assess ofloxacin susceptibility.

  18. The hOGG1 Ser326Cys polymorphism contributes to digestive system cancer susceptibility: evidence from 48 case-control studies.

    Science.gov (United States)

    Wang, Yang; Gao, Xujie; Wei, Feng; Zhang, Xinwei; Yu, Jinpu; Zhao, Hua; Sun, Qian; Yan, Fan; Yan, Cihui; Li, Hui; Ren, Xiubao

    2015-02-01

    The Ser326Cys polymorphism in the human 8-oxogunaine DNA glycosylase (hOGG1) gene had been implicated in cancer susceptibility. Studies investigating the associations between the Ser326Cys polymorphism and digestion cancer susceptibility showed conflicting results. Therefore, a meta-analysis was performed to derive a more precise estimation of the relationship. We conducted a meta-analysis of 48 studies that included 12,073 cancer cases and 19,557 case-free controls. We assessed the strength of the association using odds ratios (ORs) with 95% confidence intervals (CIs). In our analysis, the hOGG1 Ser326Cys polymorphism was significantly associated with the risk of digestive system cancers (Cys/Cys vs. Ser/Ser: OR = 1.17, 95% CI = 1.00-1.35, P digestive cancers.

  19. Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity

    Science.gov (United States)

    Robinson, Mike JF; Burghardt, Paul R; Patterson, Christa M; Nobile, Cameron W; Akil, Huda; Watson, Stanley J; Berridge, Kent C; Ferrario, Carrie R

    2015-01-01

    Pavlovian cues associated with junk-foods (caloric, highly sweet, and/or fatty foods), like the smell of brownies, can elicit craving to eat and increase the amount of food consumed. People who are more susceptible to these motivational effects of food cues may have a higher risk for becoming obese. Further, overconsumption of junk-foods leading to the development of obesity may itself heighten attraction to food cues. Here, we used a model of individual susceptibility to junk-foods diet-induced obesity to determine whether there are pre-existing and/or diet-induced increases in attraction to and motivation for sucrose-paired cues (ie, incentive salience or ‘wanting’). We also assessed diet- vs obesity-associated alterations in mesolimbic function and receptor expression. We found that rats susceptible to diet-induced obesity displayed heightened conditioned approach prior to the development of obesity. In addition, after junk-food diet exposure, those rats that developed obesity also showed increased willingness to gain access to a sucrose cue. Heightened ‘wanting’ was not due to individual differences in the hedonic impact (‘liking’) of sucrose. Neurobiologically, Mu opioid receptor mRNA expression was lower in striatal ‘hot-spots’ that generate eating or hedonic impact only in those rats that became obese. In contrast, prolonged exposure to junk-food resulted in cross-sensitization to amphetamine-induced locomotion and downregulation of striatal D2R mRNA regardless of the development of obesity. Together these data shed light on individual differences in behavioral and neurobiological consequences of exposure to junk-food diets and the potential contribution of incentive sensitization in susceptible individuals to greater food cue-triggered motivation. PMID:25761571

  20. Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity.

    Science.gov (United States)

    Robinson, Mike J F; Burghardt, Paul R; Patterson, Christa M; Nobile, Cameron W; Akil, Huda; Watson, Stanley J; Berridge, Kent C; Ferrario, Carrie R

    2015-08-01

    Pavlovian cues associated with junk-foods (caloric, highly sweet, and/or fatty foods), like the smell of brownies, can elicit craving to eat and increase the amount of food consumed. People who are more susceptible to these motivational effects of food cues may have a higher risk for becoming obese. Further, overconsumption of junk-foods leading to the development of obesity may itself heighten attraction to food cues. Here, we used a model of individual susceptibility to junk-foods diet-induced obesity to determine whether there are pre-existing and/or diet-induced increases in attraction to and motivation for sucrose-paired cues (ie, incentive salience or 'wanting'). We also assessed diet- vs obesity-associated alterations in mesolimbic function and receptor expression. We found that rats susceptible to diet-induced obesity displayed heightened conditioned approach prior to the development of obesity. In addition, after junk-food diet exposure, those rats that developed obesity also showed increased willingness to gain access to a sucrose cue. Heightened 'wanting' was not due to individual differences in the hedonic impact ('liking') of sucrose. Neurobiologically, Mu opioid receptor mRNA expression was lower in striatal 'hot-spots' that generate eating or hedonic impact only in those rats that became obese. In contrast, prolonged exposure to junk-food resulted in cross-sensitization to amphetamine-induced locomotion and downregulation of striatal D2R mRNA regardless of the development of obesity. Together these data shed light on individual differences in behavioral and neurobiological consequences of exposure to junk-food diets and the potential contribution of incentive sensitization in susceptible individuals to greater food cue-triggered motivation.

  1. Antifungal susceptibility of 205 Candida spp. isolated primarily during invasive Candidiasis and comparison of the Vitek 2 system with the CLSI broth microdilution and Etest methods.

    Science.gov (United States)

    Bourgeois, N; Dehandschoewercker, L; Bertout, S; Bousquet, P-J; Rispail, P; Lachaud, L

    2010-01-01

    Infections due to Candida spp. are frequent, particularly in immunocompromised and intensive care unit patients. Antifungal susceptibility tests are now required to optimize antifungal treatment given the emergence of acquired antifungal resistance in some Candida species. An antifungal susceptibility automated method, the Vitek 2 system (VK2), was evaluated. VK2 was compared to the CLSI broth microdilution reference method and the Etest procedure. For this purpose, 205 clinical isolates of Candida spp., including 11 different species, were tested for fluconazole, voriconazole, and amphotericin B susceptibility. For azoles, essential agreement ranged from 25% to 100%, depending on the method used and the Candida species tested. Categorical agreements for all of the species averaged 92.2% and ranged from 14.3 to 100%, depending on the 24-h or 48-h MIC reading by the Etest and CLSI methods and on the Candida species. Results obtained for Candida albicans showed excellent categorical and essential agreements with the two comparative methods. For Candida glabrata, the essential agreement was high with the CLSI method but low with the Etest method, and several very major errors in interpretation were observed between VK2 and the Etest method for both azoles. Low MICs of fluconazole were obtained for all of the Candida krusei isolates, but the VK2 expert software corrected all of the results obtained to resistant. Amphotericin B results showed MICs of CLSI), and 202 (Etest) isolates. The AST-YS01 Vitek 2 card system (bioMérieux) is a reliable and practical standardized automated antifungal susceptibility test. Nevertheless, more assays are needed to better evaluate C. glabrata fluconazole sensitivity.

  2. Antifungal Susceptibility of 205 Candida spp. Isolated Primarily during Invasive Candidiasis and Comparison of the Vitek 2 System with the CLSI Broth Microdilution and Etest Methods▿

    Science.gov (United States)

    Bourgeois, N.; Dehandschoewercker, L.; Bertout, S.; Bousquet, P.-J.; Rispail, P.; Lachaud, L.

    2010-01-01

    Infections due to Candida spp. are frequent, particularly in immunocompromised and intensive care unit patients. Antifungal susceptibility tests are now required to optimize antifungal treatment given the emergence of acquired antifungal resistance in some Candida species. An antifungal susceptibility automated method, the Vitek 2 system (VK2), was evaluated. VK2 was compared to the CLSI broth microdilution reference method and the Etest procedure. For this purpose, 205 clinical isolates of Candida spp., including 11 different species, were tested for fluconazole, voriconazole, and amphotericin B susceptibility. For azoles, essential agreement ranged from 25% to 100%, depending on the method used and the Candida species tested. Categorical agreements for all of the species averaged 92.2% and ranged from 14.3 to 100%, depending on the 24-h or 48-h MIC reading by the Etest and CLSI methods and on the Candida species. Results obtained for Candida albicans showed excellent categorical and essential agreements with the two comparative methods. For Candida glabrata, the essential agreement was high with the CLSI method but low with the Etest method, and several very major errors in interpretation were observed between VK2 and the Etest method for both azoles. Low MICs of fluconazole were obtained for all of the Candida krusei isolates, but the VK2 expert software corrected all of the results obtained to resistant. Amphotericin B results showed MICs of ≤1 mg/liter for 201 (VK2), 190 (CLSI), and 202 (Etest) isolates. The AST-YS01 Vitek 2 card system (bioMérieux) is a reliable and practical standardized automated antifungal susceptibility test. Nevertheless, more assays are needed to better evaluate C. glabrata fluconazole sensitivity. PMID:19889902

  3. Logged In and Zoned Out.

    Science.gov (United States)

    Ravizza, Susan M; Uitvlugt, Mitchell G; Fenn, Kimberly M

    2017-02-01

    Laptop computers are widely prevalent in university classrooms. Although laptops are a valuable tool, they offer access to a distracting temptation: the Internet. In the study reported here, we assessed the relationship between classroom performance and actual Internet usage for academic and nonacademic purposes. Students who were enrolled in an introductory psychology course logged into a proxy server that monitored their online activity during class. Past research relied on self-report, but the current methodology objectively measured time, frequency, and browsing history of participants' Internet usage. In addition, we assessed whether intelligence, motivation, and interest in course material could account for the relationship between Internet use and performance. Our results showed that nonacademic Internet use was common among students who brought laptops to class and was inversely related to class performance. This relationship was upheld after we accounted for motivation, interest, and intelligence. Class-related Internet use was not associated with a benefit to classroom performance.

  4. Case-Logging Practices in Otolaryngology Residency Training: National Survey of Residents and Program Directors.

    Science.gov (United States)

    Dermody, Sarah M; Gao, William; McGinn, Johnathan D; Malekzadeh, Sonya

    2017-06-01

    Objective (1) Evaluate the consistency and manner in which otolaryngology residents log surgical cases. (2) Assess the extent of instruction and guidance provided by program directors on case-logging practices. Study Design Cross-sectional national survey. Setting Accreditation Council for Graduate Medical Education otolaryngology residency programs in the United States. Subjects and Methods US otolaryngology residents, postgraduate year 2 through graduating chiefs as of July 2016, were recruited to respond to an anonymous questionnaire designed to characterize surgical case-logging practices. Program directors of US otolaryngology residency programs were recruited to respond to an anonymous questionnaire to elucidate how residents are instructed to log cases. Results A total of 272 residents and 53 program directors completed the survey, yielding response rates of 40.6% and 49.5%, respectively. Perceived accuracy of case logs is low among residents and program directors. Nearly 40% of residents purposely choose not to log certain cases, and 65.1% of residents underreport cases performed. More than 80% of program directors advise residents to log procedures performed outside the operating room, yet only 16% of residents consistently log such cases. Conclusion Variability in surgical case-logging behaviors and differences in provided instruction highlight the need for methods to improve consistency of logging practices. It is imperative to standardize practices across otolaryngology residency programs for case logs to serve as an accurate measure of surgical competency. This study provides a foundation for reform efforts within residency programs and for the Resident Case Log System.

  5. Revealing different systems responses to brown planthopper infestation for pest susceptible and resistant rice plants with the combined metabonomic and gene-expression analysis.

    Science.gov (United States)

    Liu, Caixiang; Hao, Fuhua; Hu, Jing; Zhang, Weilin; Wan, Linglin; Zhu, Lili; Tang, Huiru; He, Guangcun

    2010-12-03

    Brown planthopper (BPH) is a notorious pest of rice plants attacking leaf sheaths and seriously affecting global rice production. However, how rice plants respond against BPH remains to be fully understood. To understand systems metabolic responses of rice plants to BPH infestation, we analyzed BPH-induced metabolic changes in leaf sheaths of both BPH-susceptible and resistant rice varieties using NMR-based metabonomics and measured expression changes of 10 relevant genes using quantitative real-time PCR. Our results showed that rice metabonome was dominated by more than 30 metabolites including sugars, organic acids, amino acids, and choline metabolites. BPH infestation caused profound metabolic changes for both BPH-susceptible and resistant rice plants involving transamination, GABA shunt, TCA cycle, gluconeogenesis/glycolysis, pentose phosphate pathway, and secondary metabolisms. BPH infestation caused more drastic overall metabolic changes for BPH-susceptible variety and more marked up-regulations for key genes regulating GABA shunt and biosynthesis of secondary metabolites for BPH-resistant variety. Such observations indicated that activation of GABA shunt and shikimate-mediated secondary metabolisms was vital for rice plants to resist BPH infestation. These findings filled the gap of our understandings in the mechanistic aspects of BPH resistance for rice plants and demonstrated the combined metabonomic and qRT-PCR analysis as an effective approach for understanding plant-herbivore interactions.

  6. WMS -Warehouse Management System: adaptação proposta para o gerenciamento da logística reversa WMS -Warehouse Management System: adaptation propused for the management of the reverse logistics

    OpenAIRE

    Patrícia Guarnieri; Daniele Chrusciack; Ivanir Luiz de Oliveira; Kazuo Hatakeyama; Luciano Scandelari

    2006-01-01

    Com o advento da globalização, e o conseqüente atendimento a mercados distantes e alta rotatividade dos estoques, os armazéns descartam quantidades enormes de materiais ao final do processo logístico. Estes materiais, além de representarem considerável valor econômico, podem causar danos ao meio ambiente se descartados de forma indiscriminada. Umas das formas de evitar estes problemas, é através da adoção de técnicas de Gerenciamento da Cadeia de Suprimentos Reversa. Para que estas técnicas s...

  7. Monte Carlo Numerical Models for Nuclear Logging Applications

    Directory of Open Access Journals (Sweden)

    Fusheng Li

    2012-06-01

    Full Text Available Nuclear logging is one of most important logging services provided by many oil service companies. The main parameters of interest are formation porosity, bulk density, and natural radiation. Other services are also provided from using complex nuclear logging tools, such as formation lithology/mineralogy, etc. Some parameters can be measured by using neutron logging tools and some can only be measured by using a gamma ray tool. To understand the response of nuclear logging tools, the neutron transport/diffusion theory and photon diffusion theory are needed. Unfortunately, for most cases there are no analytical answers if complex tool geometry is involved. For many years, Monte Carlo numerical models have been used by nuclear scientists in the well logging industry to address these challenges. The models have been widely employed in the optimization of nuclear logging tool design, and the development of interpretation methods for nuclear logs. They have also been used to predict the response of nuclear logging systems for forward simulation problems. In this case, the system parameters including geometry, materials and nuclear sources, etc., are pre-defined and the transportation and interactions of nuclear particles (such as neutrons, photons and/or electrons in the regions of interest are simulated according to detailed nuclear physics theory and their nuclear cross-section data (probability of interacting. Then the deposited energies of particles entering the detectors are recorded and tallied and the tool responses to such a scenario are generated. A general-purpose code named Monte Carlo N– Particle (MCNP has been the industry-standard for some time. In this paper, we briefly introduce the fundamental principles of Monte Carlo numerical modeling and review the physics of MCNP. Some of the latest developments of Monte Carlo Models are also reviewed. A variety of examples are presented to illustrate the uses of Monte Carlo numerical models

  8. NADIR: Monitoring, Error Handling, and Logging with Tango

    Science.gov (United States)

    De Marco, M.; Knapic, C.; Smareglia, R.

    2014-05-01

    The ingest and transport of a large amount of astronomical data, in geographically distributed archives, imply some challenging issues, like remote control and configuration, monitoring and logging anomalous conditions, fault tolerance and error handling. Based on this considerations and on our experience in data management, we started development of a New Archiving Distributed InfrastructuRe (NADIR), using Tango (Team 2013; S. Gara 2012), a well known distributed control system (DCSs) within scientific environments, taking advantage of its key features, like reliability, scalability, logging and alarm system, consolidated pattern and template, to solve this complexity. In this paper we discuss about design choices and technical aspects around this project.

  9. Face logging in Copenhagen Limestone, Denmark

    DEFF Research Database (Denmark)

    Jakobsen, Lisa; Foged, Niels Nielsen; Erichsen, Lars

    2015-01-01

    The requirement for excavation support can be assessed from face logging. Face logs can also improve our knowledge of lithological and structural conditions within bedrock and supplement information from boreholes and geophysical logs. During the construction of 8 km metro tunnel and 4 km heating...... tunnel in Copenhagen more than 2.5 km face logs were made in 467 locations at underground stations, shafts, caverns and along bored tunnels. Over 160 geotechnical boreholes, many with geophysical logging were executed prior to construction works. The bedrock consists of Paleogene "Copenhagen limestone......" and face logs show a sub-horizontally layered structure, with alternate extremely weak to extremely strong beds of variable thickness. The rhythmicity is thought to be climatically controlled. Stronger beds represent reduced sedimentation rate related to climatic deterioration while weaker beds result from...

  10. The follow-up system in the purchase procedure and logistics in a public organization O sistema de acompanhamento em compras e logística numa organização pública

    Directory of Open Access Journals (Sweden)

    Mauricio Kalau Gonzales

    2003-11-01

    Full Text Available The Article discuss the applicability of the follow-up system in purchase and logistics in a public organization. The study took place at the restaurant (R.U. of the State University of Londrina (UEL. After gathering information and relevant data and analyzing the results obtained, it was possible to verify that the follow-up system in the purchase procedure is informally used in that location, despite its importance. It could also be noticed that the university does not use the same system with the other units that integrate it. When comparing a public and a private company it is possible to conclude that the system used in a private company is more complete, as it is considered a routine procedure of the purchase department. As for the logistics system which integrates the purchase system, it was possible to verify that there are flaws in its conception and use, generating deviation and loss of resources used in the public sector. Some possible ways to solve the raised problems were pointed out, such as: the possibility of adopting the system of public concession in the same way that it is adopted in other public services in the city of LondrinaO artigo analisa a aplicabilidade do sistema de acompanhamento em compras e da logística numa organização pública. O local estudado foi o restaurante universitário (R.U. na Universidade Estadual de Londrina. Após terem sido colhidas as informações e os dados pertinentes, apresentados para o foco do problema e analisados os resultados obtidos, verificou-se que o sistema de acompanhamento em compras é utilizado informalmente no órgão especificado, apesar de sua importância, embora na universidade, não se adote o mesmo sistema para os órgãos que a integram. Na comparação feita entre uma empresa pública e a caracterização do sistema em uma empresa privada, verificou-se que o sistema utilizado na empresa privada é mais completo, como um procedimento rotineiro de serviço do departamento

  11. South Korea- Potential Market for Russian Logs

    OpenAIRE

    Tak, K.

    1994-01-01

    Korea with its over 40 million population and small forest land base relies heavily on imports for its wood consumption. Korea is usually the second largest log importer in the world after Japan. Since the worsening importing conditions in the traditional log suppling countries, Korea has always looked for alternative supply sources which could provide logs with better conditions. The Russian Far East has emerged as a new source of supply which could meet the conditions Korea looks for since ...

  12. Well log characterization of natural gas-hydrates

    Science.gov (United States)

    Collett, Timothy S.; Lee, Myung W.

    2012-01-01

    In the last 25 years there have been significant advancements in the use of well-logging tools to acquire detailed information on the occurrence of gas hydrates in nature: whereas wireline electrical resistivity and acoustic logs were formerly used to identify gas-hydrate occurrences in wells drilled in Arctic permafrost environments, more advanced wireline and logging-while-drilling (LWD) tools are now routinely used to examine the petrophysical nature of gas-hydrate reservoirs and the distribution and concentration of gas hydrates within various complex reservoir systems. Resistivity- and acoustic-logging tools are the most widely used for estimating the gas-hydrate content (i.e., reservoir saturations) in various sediment types and geologic settings. Recent integrated sediment coring and well-log studies have confirmed that electrical-resistivity and acoustic-velocity data can yield accurate gas-hydrate saturations in sediment grain-supported (isotropic) systems such as sand reservoirs, but more advanced log-analysis models are required to characterize gas hydrate in fractured (anisotropic) reservoir systems. New well-logging tools designed to make directionally oriented acoustic and propagation-resistivity log measurements provide the data needed to analyze the acoustic and electrical anisotropic properties of both highly interbedded and fracture-dominated gas-hydrate reservoirs. Advancements in nuclear magnetic resonance (NMR) logging and wireline formation testing (WFT) also allow for the characterization of gas hydrate at the pore scale. Integrated NMR and formation testing studies from northern Canada and Alaska have yielded valuable insight into how gas hydrates are physically distributed in sediments and the occurrence and nature of pore fluids(i.e., free water along with clay- and capillary-bound water) in gas-hydrate-bearing reservoirs. Information on the distribution of gas hydrate at the pore scale has provided invaluable insight on the mechanisms

  13. Avian responses to selective logging shaped by species traits and logging practices.

    Science.gov (United States)

    Burivalova, Zuzana; Lee, Tien Ming; Giam, Xingli; Şekercioğlu, Çağan Hakkı; Wilcove, David S; Koh, Lian Pin

    2015-06-07

    Selective logging is one of the most common forms of forest use in the tropics. Although the effects of selective logging on biodiversity have been widely studied, there is little agreement on the relationship between life-history traits and tolerance to logging. In this study, we assessed how species traits and logging practices combine to determine species responses to selective logging, based on over 4000 observations of the responses of nearly 1000 bird species to selective logging across the tropics. Our analysis shows that species traits, such as feeding group and body mass, and logging practices, such as time since logging and logging intensity, interact to influence a species' response to logging. Frugivores and insectivores were most adversely affected by logging and declined further with increasing logging intensity. Nectarivores and granivores responded positively to selective logging for the first two decades, after which their abundances decrease below pre-logging levels. Larger species of omnivores and granivores responded more positively to selective logging than smaller species from either feeding group, whereas this effect of body size was reversed for carnivores, herbivores, frugivores and insectivores. Most importantly, species most negatively impacted by selective logging had not recovered approximately 40 years after logging cessation. We conclude that selective timber harvest has the potential to cause large and long-lasting changes in avian biodiversity. However, our results suggest that the impacts can be mitigated to a certain extent through specific forest management strategies such as lengthening the rotation cycle and implementing reduced impact logging. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  14. Characterization of reservoir fractures using conventional geophysical logging

    Directory of Open Access Journals (Sweden)

    Paitoon Laongsakul

    2011-04-01

    Full Text Available In hydrocarbon exploration fractures play an important role as possible pathways for the hydrocarbon flow and bythis enhancing the overall formation’s permeability. Advanced logging methods for fracture analysis, like the boreholeacoustic televiewer and Formation Microscanner (FMS are available, but these are additional and expensive tools. However,open and with water or hydrocarbon filled fractures are also sensitive to electrical and other conventional logging methods.For this study conventional logging data (electric, seismic, etc were available plus additional fracture information from FMS.Taking into account the borehole environment the results show that the micro-spherically focused log indicates fractures byshowing low resistivity spikes opposite open fractures, and high resistivity spikes opposite sealed ones. Compressional andshear wave velocities are reduced when passing trough the fracture zone, which are assumed to be more or less perpendicularto borehole axis. The photoelectric absorption curve exhibit a very sharp peak in front of a fracture filled with bariteloaded mud cake. The density log shows low density spikes that are not seen by the neutron log, usually where fractures,large vugs, or caverns exist. Borehole breakouts can cause a similar effect on the logging response than fractures, but fracturesare often present when this occurs. The fracture index calculation by using threshold and input weight was calculatedand there was in general a good agreement with the fracture data from FMS especially in fracture zones, which mainlycontribute to the hydraulic system of the reservoir. Finally, the overall results from this study using one well are promising,however further research in the combination of different tools for fracture identification is recommended as well as the useof core for further validation.

  15. Changes in antimicrobial susceptibility profile and prevalence of quinolone low-sensitive strains in subgingival plaque from acute periodontal lesions after systemic administration of sitafloxacin.

    Science.gov (United States)

    Tomita, Sachiyo; Kasai, Shunsuke; Imamura, Kentaro; Ihara, Yuichiro; Kita, Daichi; Ota, Koki; Sekino, Jin; Nakagawa, Taneaki; Saito, Atsushi

    2015-02-01

    This study aimed to assess changes in antimicrobial susceptibilities of subgingival bacteria in acute periodontal lesions following systemic administration of a new-generation fluoroquinolone, sitafloxacin and to monitor the occurrence and fate of quinolone low-sensitive strains. Patients with acute phase of chronic periodontitis were subjected to microbiological assessment of their subgingival plaque samples at baseline (A1). Sitafloxacin was then administered systemically (100 mg/day for 5 days). The microbiological examinations were repeated one week after administration (A2). Susceptibilities of clinical isolates from acute sites to various antimicrobials were determined using broth and agar dilution methods. At A2, subgingival bacteria with low sensitivity to levofloxacin were identified in four patients, and they were subjected to a follow-up microbiological examination at on the average 12 months after sitafloxacin administration (A3). The patients received initial and supportive periodontal therapy during the period A2 to A3. From the examined subgingival sites, 8 and 19 clinical isolates were obtained at A2 and A3, respectively. Some Streptococcus strains isolated at A2 were found to be resistant to levofloxacin (MIC 16-64 μg/ml), azithromycin (MIC 2->128 μg/ml) or clarithromycin (MIC 1->32 μg/ml). At A3, isolated streptococci were highly susceptible to levofloxacin (MIC 0.5-2 μg/ml), while those resistant to azithromycin or clarithromycin were still isolated. It is suggested that the presence of the quinolone low-sensitive strains in initially acute lesions after sitafloxacin administration was transient, and they do not persist in the subgingival milieu during the periodontal therapy. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Usefulness of Microscan System panels with EUCAST clinical breakpoints to evaluate the antimicrobial susceptibility of ß-lactamase producing- Gram negative isolates

    Directory of Open Access Journals (Sweden)

    Elisabetta Nucleo

    2011-12-01

    Full Text Available The study aimed to evaluate the ability of NBC45, NBC46 and NB40 Microscan (MS panels, updated to 2010 EUCAST breakpoints, to identify at species level and to correctly define the susceptibility to ß-lactams of 61 ß-lactamases (BLs producing Gram-negative isolates. A collection of 73 fully identified strains was analyzed: 21 Klebsiella spp., 17 E. coli, 15 P. mirabilis, 9 A. baumannii (Ab, 7 P. aeruginosa and 4 Enterobacter spp.. 61/73 were BLs and/or carbapenemases producers: 15 were CTX-M-1/-2/-14/-15 positive, and among them two were also VIM-1 positive. Four were TEM-52/-92, 3 PER-1, 2 SHV-12/-18 and 6 CMY-16 producers, while 11 were KPC-2/-3, 9 OXA-51/-58/-23, 8 VIM-1 and 2 IMP-13 positive. One K. oxytoca K-1 iper-producer, 11 non-BL producers/ATCC control strains and a OprD2 porin lacking P. aeruginosa were also included. All isolates were identified by Api-20E and VITEK-2 System and antibiotic susceptibilities were obtained by broth microdilution method. Resistance genes were identified by PCR and sequencing. All 73 isolates were correctly identified and a complete agreement for susceptibility patterns was observed for both ATCC control strains and non-BL clinical isolates. MS failed to detect a BL/Extended-Spectrum-ß-Lactamase (ESâL production in 5/61 cases: any ESßL alert was detected using NBC46 panel for 3/15 CTX-M positive strains and 2 VIM-1/CTX-M-15 producing K. pneumoniae isolates. Intermediate resistance to cefoxitin (MIC 16 mg/L, susceptibility to cefepime (MIC 8 mg/L for ertapenem (ETP, according to previously results. All VIM-1 producers resulted intermediate/resistant to imipenem (IP and meropenem (MP; decreased MIC values were observed in 2/8 cases. Carbapenem MICs >8 mg/L were detected for IP-13 P. aeruginosa producers; 6/9 OXA carbapenemases- producing Ab showed IP MIC >8 mg/L and 3/6 MP MIC >8 mg/L. 3/9 Ab OXA-58/-51 producers, tested using NB40 panel, were intermediate or resistant to doripenem and meropenem

  17. Logging methods and peeling of Aspen

    Science.gov (United States)

    T. Schantz-Hansen

    1948-01-01

    The logging of forest products is influenced by many factors, including the size of the trees, density of the stand, the soundness of the trees, size of the area logged, topography and soil, weather conditions, the degree of utilization, the skill of the logger and the equipment used, the distance from market, etc. Each of these factors influences not only the method...

  18. 40 CFR 90.412 - Data logging.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data logging. 90.412 Section 90.412 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF....412 Data logging. (a) A computer or any other automatic data collection (ADC) device(s) may be used as...

  19. 40 CFR 91.412 - Data logging.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data logging. 91.412 Section 91.412 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Gaseous Exhaust Test Procedures § 91.412 Data logging. (a) A...

  20. 40 CFR 89.409 - Data logging.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data logging. 89.409 Section 89.409 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... Data logging. (a) A computer or any other automatic data processing device(s) may be used as long as...

  1. Utilization and cost for animal logging operations

    Science.gov (United States)

    Suraj P. Shrestha; Bobby L. Lanford

    2001-01-01

    Forest harvesting with animals is a labor-intensive operation. Due to the development of efficient machines and high volume demands from the forest products industry, mechanization of logging developed very fast, leaving behind the traditional horse and mule logging. It is expensive to use machines on smaller woodlots, which require frequent moves if mechanically...

  2. A handy aid for hardwood log graders

    Science.gov (United States)

    M. D. Ostrander

    1952-01-01

    In hardwood log grading, the beginner encounters a formidable task: to memorize the specifications, exceptions to general rules, etc., as set down in the U. S. Forest Products Laboratory's "Hardwood Log Grades for Standard Lumber." He must refer to this text repeatedly until he becomes familiar with all the ins and outs of the job. This slows him down...

  3. Mathematical model of a smoldering log.

    Science.gov (United States)

    Fernando de Souza Costa; David. Sandberg

    2004-01-01

    A mathematical model is developed describing the natural smoldering of logs. It is considered the steady one dimensional propagation of infinitesimally thin fronts of drying, pyrolysis, and char oxidation in a horizontal semi-infinite log. Expressions for the burn rates, distribution profiles of temperature, and positions of the drying, pyrolysis, and smoldering fronts...

  4. Log sort yard economics, planning, and feasibility

    Science.gov (United States)

    John Rusty Dramm; Robert Govett; Ted Bilek; Gerry L. Jackson

    2004-01-01

    This publication discusses basic marketing and economic concepts, planning approach, and feasibility methodology for assessing log sort yard operations. Special attention is given to sorting small diameter and underutilized logs from forest restoration, fuels reduction, and thinning operations. A planned programming approach of objectively determining the feasibility...

  5. Palm distributions for log Gaussian Cox processes

    DEFF Research Database (Denmark)

    Coeurjolly, Jean-Francois; Møller, Jesper; Waagepetersen, Rasmus

    This paper reviews useful results related to Palm distributions of spatial point processes and provides a new result regarding the characterization of Palm distributions for the class of log Gaussian Cox processes. This result is used to study functional summary statistics for a log Gaussian Cox...

  6. SOME LIMIT-THEOREMS IN LOG DENSITY

    NARCIS (Netherlands)

    BERKES, [No Value; DEHLING, H

    Motivated by recent results on pathwise central limit theorems, we study in a systematic way log-average versions of classical limit theorems. For partial sums S(k) of independent r.v.'s we prove under mild technical conditions that (1/log N)SIGMA(k less-than-or-equal-to N)(1/k)I{S(k)/a(k)

  7. Aggregation of log-linear risks

    DEFF Research Database (Denmark)

    Embrechts, Paul; Hashorva, Enkeleijd; Mikosch, Thomas Valentin

    2014-01-01

    In this paper we work in the framework of a k-dimensional vector of log-linear risks. Under weak conditions on the marginal tails and the dependence structure of a vector of positive risks, we derive the asymptotic tail behaviour of the aggregated risk {and present} an application concerning log...

  8. Correlation of T-log with E-log in coal-bearing formations

    Science.gov (United States)

    Kayal, J. R.

    1980-03-01

    The profile of temperature gradient versus depth (T-log) has been found to be very useful for correlation with electrical resistivity log (E-log) in coal-bearing formations. A positive correlation between electrical resistivity and thermal resistivity is observed in coal sections whereas a negative correlation is found in sandstone/shale beds, thus helping in coal prospect evaluation. T logs have been used to correct the location of coal bed which had apparently been misinterpreted by the E-log. Hole to hole correlation of T-log and E-log is found to be excellent and it is observed that thermal resistivity characteristics of given formations remain fairly uniform. A rough estimation of coal grade is possible from the detailed study of the T-logs. Abrupt changes of temperature gradient as also its reversals have been observed in burnt coal sections.

  9. Extending process logs with events from supplementary sources

    NARCIS (Netherlands)

    Mannhardt, F.; De Leoni, M.; Reijers, H.A.

    2015-01-01

    Since organizations typically use more than a single IT system, information about the execution of a process is rarely available in a single event log. More commonly, data is scattered across different locations and unlinked by common case identifiers. We present a method to extend an incomplete

  10. Mining workflow processes from distributed workflow enactment event logs

    Directory of Open Access Journals (Sweden)

    Kwanghoon Pio Kim

    2012-12-01

    Full Text Available Workflow management systems help to execute, monitor and manage work process flow and execution. These systems, as they are executing, keep a record of who does what and when (e.g. log of events. The activity of using computer software to examine these records, and deriving various structural data results is called workflow mining. The workflow mining activity, in general, needs to encompass behavioral (process/control-flow, social, informational (data-flow, and organizational perspectives; as well as other perspectives, because workflow systems are "people systems" that must be designed, deployed, and understood within their social and organizational contexts. This paper particularly focuses on mining the behavioral aspect of workflows from XML-based workflow enactment event logs, which are vertically (semantic-driven distribution or horizontally (syntactic-driven distribution distributed over the networked workflow enactment components. That is, this paper proposes distributed workflow mining approaches that are able to rediscover ICN-based structured workflow process models through incrementally amalgamating a series of vertically or horizontally fragmented temporal workcases. And each of the approaches consists of a temporal fragment discovery algorithm, which is able to discover a set of temporal fragment models from the fragmented workflow enactment event logs, and a workflow process mining algorithm which rediscovers a structured workflow process model from the discovered temporal fragment models. Where, the temporal fragment model represents the concrete model of the XML-based distributed workflow fragment events log.

  11. A second look at cable logging in the Appalachians

    Science.gov (United States)

    Harry G. Gibson; Cleveland J. Biller

    1975-01-01

    Cable logging, once used extensively in the Appalachians, is being re-examined to see if smaller, more mobile systems can help solve some of the timber-managment problems on steep slopes. A small Austrian skyline was tested in West Virginia to determine its feasibility for harvesting enstern hardwoods. The short-term test included both selection and clearcut harvesting...

  12. Grading options for western hemlock "pulpwood" logs from southeastern Alaska.

    Science.gov (United States)

    David W. Green; Kent A. McDonald; John. Dramm; Kenneth. Kilborn

    Properties and grade yield are estimated for structural lumber produced from No. 3, No. 4, and low-end No. 2 grade western hemlock logs of the type previously used primarily for the production of pulp chips. Estimates are given for production in the Structural Framing, Machine Stress Rating, and Laminating Stock grading systems. The information shows that significant...

  13. Log-normal based mutation evolutionary programming technique for ...

    African Journals Online (AJOL)

    Economic dispatch requires a reliable optimization technique so loss is minimal. This paper presents Log-Normal Evolutionary Programming (LNEP) technique for solving Economic Dispatch (ED) problem considering loss minimization. Validations on the IEEE 6-bus and IEEE 26-bus test systems demonstrated that LNEP is ...

  14. Estimating two indirect logging costs caused by accelerated erosion.

    Science.gov (United States)

    Glen O. Klock

    1976-01-01

    In forest areas where high soil erosion potential exists, a comparative yarding cost estimate, including the indirect costs determined by methods proposed here, shows that the total cost of using "advanced" logging methods may be less than that of "traditional" systems.

  15. Proposed geologic model based on geophysical well logs

    Energy Technology Data Exchange (ETDEWEB)

    Diaz C, S.; Puente C, I.; de la Pena L, A.

    1981-01-01

    An investigation of the subsurface based on a qualitative interpretation of well logs was carried out at Cerro Prieto to obtain information on the distribution of the different lithofacies that make up a deltaic depositional system. The sedimentological interpretation derived from the resistivity and spontaneous potential are shown in several cross-sections of the field. In addition to the sedimentological interpretation, a map of the structural geology of the region based on well logs and available geophysical information was prepared, including the results of gravity and seismic refraction surveys. The depth to the zone of hydrothermal alteration described by Elders (1980) was found by means of temperature, electrical, and radioactive logs. Two maps showing the configuration of the top of this anomaly show a clear correlation with the gravity anomalies found in the area.

  16. Application of oil-field well log interpretation techniques to the Cerro Prieto Geothermal Field

    Energy Technology Data Exchange (ETDEWEB)

    Ershaghi, I.; Phillips, L.B.; Dougherty, E.L.; Handy, L.L.

    1979-10-01

    An example is presented of the application of oil-field techniques to the Cerro Prieto Field, Mexico. The lithology in this field (sand-shale lithology) is relatively similar to oil-field systems. The study was undertaken as a part of the first series of case studies supported by the Geothermal Log Interpretation Program (GLIP) of the US Department of Energy. The suites of logs for individual wells were far from complete. This was partly because of adverse borehole conditions but mostly because of unavailability of high-temperature tools. The most complete set of logs was a combination of Dual Induction Laterolog, Compensated Formation Density Gamma Ray, Compensated Neutron Log, and Saraband. Temperature data about the wells were sketchy, and the logs had been run under pre-cooled mud condition. A system of interpretation consisting of a combination of graphic and numerical studies was used to study the logs. From graphical studies, evidence of hydrothermal alteration may be established from the trend analysis of SP (self potential) and ILD (deep induction log). Furthermore, the cross plot techniques using data from density and neutron logs may help in establishing compaction as well as rock density profile with depth. In the numerical method, R/sub wa/ values from three different resistivity logs were computed and brought into agreement. From this approach, values of formation temperature and mud filtrate resistivity effective at the time of logging were established.

  17. Face logging in Copenhagen Limestone, Denmark

    DEFF Research Database (Denmark)

    Jakobsen, Lisa; Foged, Niels Nielsen; Erichsen, Lars

    2015-01-01

    The requirement for excavation support can be assessed from face logging. Face logs can also improve our knowledge of lithological and structural conditions within bedrock and supplement information from boreholes and geophysical logs. During the construction of 8 km metro tunnel and 4 km heating...... tunnel in Copenhagen more than 2.5 km face logs were made in 467 locations at underground stations, shafts, caverns and along bored tunnels. Over 160 geotechnical boreholes, many with geophysical logging were executed prior to construction works. The bedrock consists of Paleogene "Copenhagen limestone...... the limestone is presented along with a longsection showing the sub-horizontal layering. Knowledge of the lateral bed continuity can be used to predict challenging levels within the limestone and levels more favourable for tunnelling....

  18. Effects of Different Logging Techniques on Forest Soil Compaction at Mountainous Terrain

    Directory of Open Access Journals (Sweden)

    Habip Eroğlu

    2012-11-01

    Full Text Available In this study, it was investigated that the effects of different logging techniques on forest soil compaction in the Artvin region. For this purpose, soil penetration resistance was measured in a total of 12 experimental areas where each with 3 pieces, including logging with forest skyline, forest tractor, manpower and chute systems using penetrologger. As a result, changes of penetration resistances values at where logging with manpower and forest tractor according to control points were higher than logging with forest skyline and chute systems.

  19. Long term corrosion of iron at the water logged site Nydam in Denmark

    DEFF Research Database (Denmark)

    Matthiesen, Henning; Hilbert, Lisbeth Rischel; Gregory, David

    2005-01-01

    Long term corrosion of iron at the water logged site Nydam in Denmark; studies of enviroment, archaeological artefacts, and modern analogues, Prediction of long term corrosion behaviour in nuclear waste systems.......Long term corrosion of iron at the water logged site Nydam in Denmark; studies of enviroment, archaeological artefacts, and modern analogues, Prediction of long term corrosion behaviour in nuclear waste systems....

  20. An Analysis of the Differences among Log Scaling Methods and Actual Log Volume

    Science.gov (United States)

    R. Edward Thomas; Neal D. Bennett

    2017-01-01

    Log rules estimate the volume of green lumber that can be expected to result from the sawing of a log. As such, this ability to reliably predict lumber recovery forms the foundation of log sales and purchase. The more efficient a sawmill, the less the scaling methods reflect the actual volume recovery and the greater the overrun factor. Using high-resolution scanned...

  1. LOG2MARKUP: State module to transform a Stata text log into a markup document

    DEFF Research Database (Denmark)

    2016-01-01

    log2markup extract parts of the text version from the Stata log command and transform the logfile into a markup based document with the same name, but with extension markup (or otherwise specified in option extension) instead of log. The author usually uses markdown for writing documents. However...

  2. Continuous exposure to Plasmodium results in decreased susceptibility and transcriptomic divergence of the Anopheles gambiae immune system

    Directory of Open Access Journals (Sweden)

    Dimopoulos George

    2007-12-01

    Full Text Available Abstract Background Plasmodium infection has been shown to compromise the fitness of the mosquito vector, reducing its fecundity and longevity. However, from an evolutionary perspective, the impact of Plasmodium infection as a selective pressure on the mosquito is largely unknown. Results In the present study we have addressed the effect of a continuous Plasmodium berghei infection on the resistance to infection and global gene expression in Anopheles gambiae. Exposure of A. gambiae to P. berghei-infected blood and infection for 16 generations resulted in a decreased susceptibility to infection, altered constitutive expression levels for approximately 2.4% of the mosquito's total transcriptome and a lower basal level of immune genes expression, including several anti-Plasmodium factors. The infection-responsiveness for several defense genes was elevated in the P. berghei exposed mosquito colonies. Conclusion Our study establishes the existence of a selective pressure exerted by the parasite P. berghei on the malaria vector A. gambiae that results in a decreased permissiveness to infection and changes in the mosquito transcriptome regulation that suggest a decreased constitutive immune gene activity but a more potent immune response upon Plasmodium challenge.

  3. Downsizing nature: managing risk and knowledge economies through production subcontracting in the Oregon logging sector

    OpenAIRE

    W Scott Prudham

    2002-01-01

    The logging sector in Oregon is characterized by extensive subcontracting between wood-commodity manufacturing firms and independent logging contractors. Why is this so? Considerable recent scholarship has examined the dynamics of flexible production systems, including regional contractor networks, as prominent aspects of late capitalism. Although useful, existing accounts of flexibility are inadequate to explain why logging in particular would be subject to contract production relations. A s...

  4. Interaction between primary and secondary sporocysts of Schistosoma mansoni and the internal defence system of Biomphalaria resistant and susceptible to the parasite

    Directory of Open Access Journals (Sweden)

    Ana Carolina Alves de Mattos

    2011-06-01

    Full Text Available The outcome of the interaction between Biomphalaria and Schistosoma mansoni depends on the response of the host internal defence system (IDS and the escape mechanisms of the parasite. The aim of this study was to evaluate the responsiveness of the IDS (haemocytes and soluble haemolymph factors of resistant and susceptible Biomphalaria tenagophila lineages and Biomphalaria glabrata lineages in the presence of in vitro-transformed primary sporocysts and secondary sporocysts obtained from infected B. glabrata. To do this, we assayed the cellular adhesion index (CAI, analysed viability/mortality, used fluorescent markers to evaluate the tegumental damage and transplanted secondary sporocysts. B. tenagophila Taim was more effective against primary and secondary sporocystes than the susceptible lineage and B. glabrata. Compared with secondary sporocysts exposed to B. tenagophila, primary sporocysts showed a higher CAI, a greater percentage of dead sporocysts and were labelled by lectin from Glycine max and Alexa-Fluor 488 fluorescent probes at a higher rate than the secondary sporocysts. However, the two B. tenagophila lineages showed no cercarial shedding after inoculation with secondary sporocysts. Our hypothesis that secondary sporocysts can escape the B. tenagophila IDS cannot be confirmed by the transplantation experiments. These data suggest that there are additional mechanisms involved in the lower susceptibilty of B. tenagophila to S. mansoni infection.

  5. As distribuições Kumaraswamy-log-logística e Kumaraswamy-logística

    OpenAIRE

    Tiago Viana Flor de Santana

    2010-01-01

    Neste trabalho apresenta-se duas novas distribuições de probabilidade obtidas de dois métodos de generalização da distribuição log-logística com dois parâmetros (LL(?,?)). O primeiro método descrito em Marshall e Olkin (1997) transforma a nova distribuição, agora com três parâmetros e denominada distribuição log-logística modificada (LLM (v,?,?)), mais flexível porém, não muda a forma geral da função de taxa de falha e o novo parâmetro v, não influência no cálculo da assimetria e curtose. O s...

  6. Geographic Information Systems and geomorphological mapping applied to landslide inventory and susceptibility mapping in El Estado river, Pico de Orizaba, Mexico

    Directory of Open Access Journals (Sweden)

    José Fernando Aceves Quesada

    2016-11-01

    Full Text Available With the aim of raising awareness on the prevention of landslide disasters, this work develops a methodology that incorporates geomorphological mapping into the mapping of landslide susceptibility using Geographic Information Systems (GIS and Multiple Logistic Regression (MLR. In Mexico, some studies have evaluated the stability of hillsides using GIS. However, these studies set a general framework and guidance (that includes basic concepts and explanations of landslide classification, triggering mechanisms, criteria, considerations, and analysis for landslide hazard reconnaissance, etc. for preparing a landslide atlas at state and city levels. So far, these have not developed a practical and standardized approach incorporating geomorphological maps into the landslide inventory using GIS. This paper describes the analysis conducted to develop an analytical technique and morphometric analysis for a multi-temporal landslide inventory. Three data management levels are used to create GIS thematic layers. For the first level, analogue topographic, geological, land-use, and climate paper are converted to raster format, georeferenced, and incorporated as GIS thematic layers. For the second level, five layers are derived from topographic elevation data: slope angles, slope curvature, contributing area, flow direction, and saturation. For the third level, thematic maps are derived from the previous two levels of data: a hypsometric map (heuristically classified to highlight altimetric levels, a reclassified slope map (allowing to highlight differences in relief , and a morphographic map (derived from a heuristic reclassification of the slope map to highlight volcanic landforms. The theoretical aspects of geomorphological mapping contribute to set the conceptual basis to support landslide mapping. The GIS thematic layers provide context and establish an overall characterization of landslide processes within the watershed. Through the retrieval and on

  7. Mining workflow processes from distributed workflow enactment event logs

    OpenAIRE

    Kwanghoon Pio Kim

    2012-01-01

    Workflow management systems help to execute, monitor and manage work process flow and execution. These systems, as they are executing, keep a record of who does what and when (e.g. log of events). The activity of using computer software to examine these records, and deriving various structural data results is called workflow mining. The workflow mining activity, in general, needs to encompass behavioral (process/control-flow), social, informational (data-flow), and organizational perspectives...

  8. Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides

    DEFF Research Database (Denmark)

    Jungersted, J.M.; Høgh, Julie Kaae; Hellgren, Lars

    2010-01-01

    Alitretinoin is a new drug for systemic treatment of chronic hand eczema. Previous functional tests of skin topically treated with retinoids have indicated impaired skin barrier function, but no data are available on barrier parameters after systemic alitretinoin treatment. To investigate...

  9. Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides

    DEFF Research Database (Denmark)

    Jungersted, Jakob Mutanu; Høgh, Julie Kaae; Hellgren, Lars

    2010-01-01

    Alitretinoin is a new drug for systemic treatment of chronic hand eczema. Previous functional tests of skin topically treated with retinoids have indicated impaired skin barrier function, but no data are available on barrier parameters after systemic alitretinoin treatment. To investigate the eff...

  10. SNG-log i boring ved Tinglev

    DEFF Research Database (Denmark)

    Korsbech, Uffe C C; Madsen, Peter Buch

    1999-01-01

    A 4-windows SNG-log has been run in a 185 m exploration borehole at Tinglev. A new method for examining the effect of borehole geometry on the measured gamma-spectra has been tested.......A 4-windows SNG-log has been run in a 185 m exploration borehole at Tinglev. A new method for examining the effect of borehole geometry on the measured gamma-spectra has been tested....

  11. Veneer recovery from Douglas-fir logs.

    Science.gov (United States)

    E.H. Clarke; A.C. Knauss

    1957-01-01

    During 1956, the Pacific Northwest Forest and Range Experiment Station made a series of six veneer-recovery studies in the Douglas-fir region of Oregon and Washington. The net volume of logs involved totaled approximately 777 M board-feet. Purpose of these studies was to determine volume recovery, by grade of veneer, from the four principal grades of Douglas-fir logs...

  12. Unique biofilm signature, drug susceptibility and decreased virulence in Drosophila through the Pseudomonas aeruginosa two-component system PprAB.

    Science.gov (United States)

    de Bentzmann, Sophie; Giraud, Caroline; Bernard, Christophe S; Calderon, Virginie; Ewald, Friederike; Plésiat, Patrick; Nguyen, Cathy; Grunwald, Didier; Attree, Ina; Jeannot, Katy; Fauvarque, Marie-Odile; Bordi, Christophe

    2012-01-01

    Bacterial biofilm is considered as a particular lifestyle helping cells to survive hostile environments triggered by a variety of signals sensed and integrated through adequate regulatory pathways. Pseudomonas aeruginosa, a Gram-negative bacterium causing severe infections in humans, forms biofilms and is a fantastic example for fine-tuning of the transition between planktonic and community lifestyles through two-component systems (TCS). Here we decipher the regulon of the P. aeruginosa response regulator PprB of the TCS PprAB. We identified genes under the control of this TCS and once this pathway is activated, analyzed and dissected at the molecular level the PprB-dependent phenotypes in various models. The TCS PprAB triggers a hyper-biofilm phenotype with a unique adhesive signature made of BapA adhesin, a Type 1 secretion system (T1SS) substrate, CupE CU fimbriae, Flp Type IVb pili and eDNA without EPS involvement. This unique signature is associated with drug hyper-susceptibility, decreased virulence in acutely infected flies and cytotoxicity toward various cell types linked to decreased Type III secretion (T3SS). Moreover, once the PprB pathway is activated, decreased virulence in orally infected flies associated with enhanced biofilm formation and dissemination defect from the intestinal lumen toward the hemolymph compartment is reported. PprB may thus represent a key bacterial adaptation checkpoint of multicellular and aggregative behavior triggering the production of a unique matrix associated with peculiar antibiotic susceptibility and attenuated virulence, a particular interesting breach for therapeutic intervention to consider in view of possible eradication of P. aeruginosa biofilm-associated infections.

  13. Unique biofilm signature, drug susceptibility and decreased virulence in Drosophila through the Pseudomonas aeruginosa two-component system PprAB.

    Directory of Open Access Journals (Sweden)

    Sophie de Bentzmann

    Full Text Available Bacterial biofilm is considered as a particular lifestyle helping cells to survive hostile environments triggered by a variety of signals sensed and integrated through adequate regulatory pathways. Pseudomonas aeruginosa, a Gram-negative bacterium causing severe infections in humans, forms biofilms and is a fantastic example for fine-tuning of the transition between planktonic and community lifestyles through two-component systems (TCS. Here we decipher the regulon of the P. aeruginosa response regulator PprB of the TCS PprAB. We identified genes under the control of this TCS and once this pathway is activated, analyzed and dissected at the molecular level the PprB-dependent phenotypes in various models. The TCS PprAB triggers a hyper-biofilm phenotype with a unique adhesive signature made of BapA adhesin, a Type 1 secretion system (T1SS substrate, CupE CU fimbriae, Flp Type IVb pili and eDNA without EPS involvement. This unique signature is associated with drug hyper-susceptibility, decreased virulence in acutely infected flies and cytotoxicity toward various cell types linked to decreased Type III secretion (T3SS. Moreover, once the PprB pathway is activated, decreased virulence in orally infected flies associated with enhanced biofilm formation and dissemination defect from the intestinal lumen toward the hemolymph compartment is reported. PprB may thus represent a key bacterial adaptation checkpoint of multicellular and aggregative behavior triggering the production of a unique matrix associated with peculiar antibiotic susceptibility and attenuated virulence, a particular interesting breach for therapeutic intervention to consider in view of possible eradication of P. aeruginosa biofilm-associated infections.

  14. Development of an in vitro macrophage system to assess Penicillium marneffei growth and susceptibility to nitric oxide.

    OpenAIRE

    Cogliati, M.; Roverselli, A; Boelaert, J R; Taramelli, D.; Lombardi, L,; Viviani, M A

    1997-01-01

    We investigated the effect of nitric oxide (NO) and reactive nitrogen intermediates on the in vitro growth of Penicillium marneffei both in a cell-free system and in a novel macrophage culture system. In the cell-free system, NO that was chemically generated from NaNO2 in acid media (pH 4 and 5) markedly inhibited the growth of P. marneffei. On the contrary, inhibition of growth did not occur in neutral medium (pH 7.4) in which NO was not produced. P. marneffei conidia were phagocytized by no...

  15. Comparison of predicted susceptibility between genotype and virtual phenotype HIV drug resistance interpretation systems among treatment-naive HIV-infected patients in Asia: TASER-M cohort analysis.

    Science.gov (United States)

    Jiamsakul, Awachana; Kantor, Rami; Li, Patrick C K; Sirivichayakul, Sunee; Sirisanthana, Thira; Kantipong, Pacharee; Lee, Christopher K C; Kamarulzaman, Adeeba; Ratanasuwan, Winai; Ditangco, Rossana; Singtoroj, Thida; Sungkanuparph, Somnuek

    2012-10-24

    Accurate interpretation of HIV drug resistance (HIVDR) testing is challenging, yet important for patient care. We compared genotyping interpretation, based on the Stanford University HIV Drug Resistance Database (Stanford HIVdb), and virtual phenotyping, based on the Janssen Diagnostics BVBA's vircoTYPE™ HIV-1, and investigated their level of agreement in antiretroviral (ARV) naive patients in Asia, where non-B subtypes predominate. Sequences from 1301 ARV-naive patients enrolled in the TREAT Asia Studies to Evaluate Resistance - Monitoring Study (TASER-M) were analysed by both interpreting systems. Interpretations from both Stanford HIVdb and vircoTYPE™ HIV-1 were initially grouped into 2 levels: susceptible and non-susceptible. Discrepancy was defined as a discordant result between the susceptible and non-susceptible interpretations from the two systems for the same ARV. Further analysis was performed when interpretations from both systems were categorised into 3 levels: susceptible, intermediate and resistant; whereby discrepancies could be categorised as major discrepancies and minor discrepancies. Major discrepancy was defined as having a susceptible result from one system and resistant from the other. Minor discrepancy corresponded to having an intermediate interpretation in one system, with a susceptible or resistant result in the other. The level of agreement was analysed using the prevalence adjusted bias adjusted kappa (PABAK). Overall, the agreement was high, with each ARV being in "almost perfect agreement", using Landis and Koch's categorisation. Highest discordance was observed for efavirenz (75/1301, 5.8%), all arising from susceptible Stanford HIVdb versus non-susceptible vircoTYPE™ HIV-1 predictions. Protease Inhibitors had highest level of concordance with PABAKs all above 0.99, followed by Nucleoside Reverse Transcriptase Inhibitors with PABAKs above 0.97 and non-NRTIs with the lowest PABAK of 0.88. The 68/75 patients with discordant

  16. Comparison of predicted susceptibility between genotype and virtual phenotype HIV drug resistance interpretation systems among treatment-naive HIV-infected patients in Asia: TASER-M cohort analysis

    Directory of Open Access Journals (Sweden)

    Jiamsakul Awachana

    2012-10-01

    Full Text Available Abstract Background Accurate interpretation of HIV drug resistance (HIVDR testing is challenging, yet important for patient care. We compared genotyping interpretation, based on the Stanford University HIV Drug Resistance Database (Stanford HIVdb, and virtual phenotyping, based on the Janssen Diagnostics BVBA’s vircoTYPE™ HIV-1, and investigated their level of agreement in antiretroviral (ARV naive patients in Asia, where non-B subtypes predominate. Methods Sequences from 1301 ARV-naive patients enrolled in the TREAT Asia Studies to Evaluate Resistance – Monitoring Study (TASER-M were analysed by both interpreting systems. Interpretations from both Stanford HIVdb and vircoTYPE™ HIV-1 were initially grouped into 2 levels: susceptible and non-susceptible. Discrepancy was defined as a discordant result between the susceptible and non-susceptible interpretations from the two systems for the same ARV. Further analysis was performed when interpretations from both systems were categorised into 3 levels: susceptible, intermediate and resistant; whereby discrepancies could be categorised as major discrepancies and minor discrepancies. Major discrepancy was defined as having a susceptible result from one system and resistant from the other. Minor discrepancy corresponded to having an intermediate interpretation in one system, with a susceptible or resistant result in the other. The level of agreement was analysed using the prevalence adjusted bias adjusted kappa (PABAK. Results Overall, the agreement was high, with each ARV being in “almost perfect agreement”, using Landis and Koch’s categorisation. Highest discordance was observed for efavirenz (75/1301, 5.8%, all arising from susceptible Stanford HIVdb versus non-susceptible vircoTYPE™ HIV-1 predictions. Protease Inhibitors had highest level of concordance with PABAKs all above 0.99, followed by Nucleoside Reverse Transcriptase Inhibitors with PABAKs above 0.97 and non-NRTIs with the

  17. Logging legacies affect insect pollinator communities in southern Appalachian forests

    Science.gov (United States)

    Michelle M. Jackson; Monica G. Turner; Scott M. Pearson

    2014-01-01

    Many temperate deciduous forests are recovering from past logging, but the effects of logging legacies and environmental gradients on forest insect pollinators have not been well studied. In this study, we asked how pollinator abundance and community composition varied with distance from logging roads and elevation in old (logged >90 years ago) and young (logged 20–...

  18. Logging, arboricide treatments and regeneration at Budongo Forest ...

    African Journals Online (AJOL)

    A study was carried out to detect whether logging and arboricide treatments had influences on floristic composition of four compartments in Budongo Forest, Uganda. The compartments were (N15) which had never been logged or treated; B4) logged 50 years; N4 logged 40 years, and W2I logged 30 years ago. The species ...

  19. Woody plant regeneration after blowdown, salvage logging, and prescribed fire in a northern Minnesota forest

    Science.gov (United States)

    Brian J. Palik; Doug. Kastendick

    2009-01-01

    Salvage logging after natural disturbance has received increased scrutiny in recent years because of concerns over detrimental effects on tree regeneration and increased fine fuel levels. Most research on tree regeneration after salvage logging comes from fire-prone systems and is short-term in scope. Limited information is available on longer term responses to salvage...

  20. A simplified hardwood log-sawing program for three-dimensional profile data

    Science.gov (United States)

    R. Edward. Thomas

    2011-01-01

    Current laser scanning systems in sawmills collect low-resolution three-dimensional (3D) profiles of logs. However, these scanners are capable of much more. As a demonstration, the U.S. Forest Service, Forestry Sciences Laboratory in Princeton, WV, constructed a 3D laser log scanner using off -the-shelf industrial scanning components.

  1. Using parallel computing methods to improve log surface defect detection methods

    Science.gov (United States)

    R. Edward Thomas; Liya. Thomas

    2013-01-01

    Determining the size and location of surface defects is crucial to evaluating the potential yield and value of hardwood logs. Recently a surface defect detection algorithm was developed using the Java language. This algorithm was developed around an earlier laser scanning system that had poor resolution along the length of the log (15 scan lines per foot). A newer...

  2. Using the Logarithmic Concentration Diagram, Log "C", to Teach Acid-Base Equilibrium

    Science.gov (United States)

    Kovac, Jeffrey

    2012-01-01

    Acid-base equilibrium is one of the most important and most challenging topics in a typical general chemistry course. This article introduces an alternative to the algebraic approach generally used in textbooks, the graphical log "C" method. Log "C" diagrams provide conceptual insight into the behavior of aqueous acid-base systems and allow…

  3. Assessing the feasibility and profitability of cable logging in southern upland hardwood forests

    Science.gov (United States)

    Chris B. LeDoux; Dennis M. May; Tony Johnson; Richard H. Widmann

    1995-01-01

    Procedures developed to assess available timber supplies from upland hardwood forest statistics reported by the USDA Forest Services' Forest Inventory and Analysis unit were modified to assess the feasibility and profitability of cable logging in southern upland hardwood forests. Depending on the harvest system and yarding distance used, cable logging can be...

  4. The interactive impact of forest site and stand attributes and logging technology on stand management

    Science.gov (United States)

    C.B. LeDoux; J.E. Baumgras

    1991-01-01

    The impact of selected site and stand attributes on stand management is demonstrated using actual forest model plot data and a complete systems simulation model called MANAGE. The influence of terrain on the type of logging technology required to log a stand and the resulting impact on stand management is also illustrated. The results can be used by managers and...

  5. A small-diameter NMR logging tool for groundwater investigations

    Science.gov (United States)

    Walsh, David; Turner, Peter; Grunewald, Elliot; Zhang, Hong; Butler, James J.; Reboulet, Ed; Knobbe, Steve; Christy, Tom; Lane, John W.; Johnson, Carole D.; Munday, Tim; Fitzpatrick, Andrew

    2013-01-01

    A small-diameter nuclear magnetic resonance (NMR) logging tool has been developed and field tested at various sites in the United States and Australia. A novel design approach has produced relatively inexpensive, small-diameter probes that can be run in open or PVC-cased boreholes as small as 2 inches in diameter. The complete system, including surface electronics and various downhole probes, has been successfully tested in small-diameter monitoring wells in a range of hydrogeological settings. A variant of the probe that can be deployed by a direct-push machine has also been developed and tested in the field. The new NMR logging tool provides reliable, direct, and high-resolution information that is of importance for groundwater studies. Specifically, the technology provides direct measurement of total water content (total porosity in the saturated zone or moisture content in the unsaturated zone), and estimates of relative pore-size distribution (bound vs. mobile water content) and hydraulic conductivity. The NMR measurements show good agreement with ancillary data from lithologic logs, geophysical logs, and hydrogeologic measurements, and provide valuable information for groundwater investigations.

  6. A small-diameter NMR logging tool for groundwater investigations.

    Science.gov (United States)

    Walsh, David; Turner, Peter; Grunewald, Elliot; Zhang, Hong; Butler, James J; Reboulet, Ed; Knobbe, Steve; Christy, Tom; Lane, John W; Johnson, Carole D; Munday, Tim; Fitzpatrick, Andrew

    2013-01-01

    A small-diameter nuclear magnetic resonance (NMR) logging tool has been developed and field tested at various sites in the United States and Australia. A novel design approach has produced relatively inexpensive, small-diameter probes that can be run in open or PVC-cased boreholes as small as 2 inches in diameter. The complete system, including surface electronics and various downhole probes, has been successfully tested in small-diameter monitoring wells in a range of hydrogeological settings. A variant of the probe that can be deployed by a direct-push machine has also been developed and tested in the field. The new NMR logging tool provides reliable, direct, and high-resolution information that is of importance for groundwater studies. Specifically, the technology provides direct measurement of total water content (total porosity in the saturated zone or moisture content in the unsaturated zone), and estimates of relative pore-size distribution (bound vs. mobile water content) and hydraulic conductivity. The NMR measurements show good agreement with ancillary data from lithologic logs, geophysical logs, and hydrogeologic measurements, and provide valuable information for groundwater investigations. © 2013, National Ground Water Association.

  7. C-reactive protein +1444CT (rs1130864) genetic polymorphism is associated with the susceptibility to systemic lupus erythematosus and C-reactive protein levels.

    Science.gov (United States)

    Delongui, Francieli; Lozovoy, Marcell Allyson Batisti; Iriyoda, Tatiana Mayiumi Veiga; Costa, Neide Tomimura; Stadtlober, Nicole Perugini; Alfieri, Daniela Frizon; Flauzino, Tamires; Dichi, Isaias; Simão, Andréa Name Colado; Reiche, Edna Maria Vissoci

    2017-08-01

    The T rare allele of +1444CT (rs1130864) polymorphism of C-reactive protein (CRP) has been associated with increased CRP levels in some inflammatory conditions, but its role on systemic lupus erythematosus (SLE) susceptibility and on CRP levels in SLE patients remains uncertain. The objective of the study was to evaluate the association between the rs1130864 CRP polymorphism with SLE susceptibility, disease activity, and CRP levels in SLE Brazilian patients. The study enrolled 176 SLE patients and 137 controls. SLE disease activity was assessed using the SLE Disease Activity Index (SLEDAI). The rs1130864 CRP polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism. SLE patients presented higher body mass index (p = 0.046) and CRP levels (p = 0.017) than controls. The genotype and allele frequencies of patients differed from controls [CC vs. CT = odds ratio (OR) 1.730, 95% confidence interval (CI) 1.068-2.803, p = 0.035; CC vs. TT = OR 3.667, 95% CI 1.410-9.533, p = 0.009; C vs. T = OR 1.883, 95% CI 1.299-2.728, p = 0.001)]. Patients carrying the T allele presented higher CRP levels (p = 0.009), were more frequent Caucasians (p = 0.018), and with no use of immunosuppressive treatment (p = 0.004) than those carrying the C allele. However, the SLEDAI and anti-double-stranded DNA positivity did not differ from those carrying T vs. C allele (p = 0.595 and p = 0.243, respectively). The rs1130864 CRP polymorphism was associated with SLE susceptibility and CRP levels, but not with disease activity, suggesting that this polymorphism may play a role in the pathophysiology of SLE through increasing the CRP that, probably, plays an inflammatory role in SLE pathophysiology.

  8. An MIF Promoter Polymorphism Is Associated with Susceptibility to Pulmonary Arterial Hypertension in Diffuse Cutaneous Systemic Sclerosis

    NARCIS (Netherlands)

    Bossini-Castillo, L.; Campillo-Davo, D.; Lopez-Isac, E.; Carmona, F.D.; Simeon, C.P.; Carreira, P.; Callejas-Rubio, J.L.; Castellvi, I.; Fernandez-Nebro, A.; Rodriguez-Rodriguez, L.; Rubio-Rivas, M.; Garcia-Hernandez, F.J.; Madronero, A.B.; Beretta, L.; Santaniello, A.; Lunardi, C.; Airo, P.; Hoffmann-Vold, A.M.; Kreuter, A.; Riemekasten, G.; Witte, T. de; Hunzelmann, N.; Vonk, M.C.; Voskuyl, A.E.; Vries-Bouwstra, J. de; Shiels, P.; Herrick, A.; Worthington, J.; Radstake, T.; Martin, J.

    2017-01-01

    OBJECTIVE: Systemic sclerosis (SSc) is a fibrotic immune-mediated disease of unknown etiology. Among its clinical manifestations, pulmonary involvement is the leading cause of mortality in patients with SSc. However, the genetic factors involved in lung complication are not well defined. We aimed to

  9. An MIF promoter polymorphism is associated with susceptibility to pulmonary arterial hypertension in diffuse cutaneous systemic sclerosis

    NARCIS (Netherlands)

    Bossini-Castillo, Lara; Campillo-Davo, Diana; Lopez-Isac, Elena; Carmona, Francisco David; Simeon, Carmen P.; Carreira, Patricia; Callejas-Rubio, Jose Luis; Castellvi, Ivan; Fernandez-Nebro, Antonio; Rodriguez-Rodriguez, Luis; Rubio-Rivas, Manel; Garcia-Hernandez, Francisco J.; Madronero, Ana Belen; Beretta, Lorenzo; Santaniello, Alessandro; Lunardi, Claudio; Airo, Paolo; Hoffmann-Vold, Anna-Maria; Kreuter, Alexander; Riemekasten, Gabriela; Witte, Torsten; Hunzelmann, Nicolas; Vonk, Madelon C.; Voskuyl, Alexandre E.; de Vries-Bouwstra, Jeska; Shiels, Paul; Herrick, Ariane; Worthington, Jane; Radstake, Timothy R.D.J.; Martin, Javier

    2017-01-01

    Objective. Systemic sclerosis (SSc) is a fibrotic immune-mediated disease of unknown etiology. Among its clinical manifestations, pulmonary involvement is the leading cause of mortality in patients with SSc. However, the genetic factors involved in lung complication are not well defined. We aimed to

  10. Comparison of EUCAST and CLSI broth microdilution methods for the susceptibility testing of 10 systemically active antifungal agents when tested against Candida spp.

    Science.gov (United States)

    Pfaller, Michael A; Castanheira, Mariana; Messer, Shawn A; Rhomberg, Paul R; Jones, Ronald N

    2014-06-01

    The antifungal broth microdilution (BMD) method of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) was compared with Clinical and Laboratory Standards Institute (CLSI) BMD method M27-A3 for amphotericin B, flucytosine, anidulafungin, caspofungin, micafungin, fluconazole, isavuconazole, itraconazole, posaconazole, and voriconazole susceptibility testing of 357 isolates of Candida. The isolates were selected from global surveillance collections to represent both wild-type (WT) and non-WT MIC results for the azoles (12% of fluconazole and voriconazole results were non-WT) and the echinocandins (6% of anidulafungin and micafungin results were non-WT). The study collection included 114 isolates of Candida albicans, 73 of C. glabrata, 76 of C. parapsilosis, 60 of C. tropicalis, and 34 of C. krusei. The overall essential agreement (EA) between EUCAST and CLSI results ranged from 78.9% (posaconazole) to 99.6% (flucytosine). The categorical agreement (CA) between methods and species of Candida was assessed using previously determined CLSI epidemiological cutoff values. The overall CA between methods was 95.0% with 2.5% very major (VM) and major (M) discrepancies. The CA was >93% for all antifungal agents with the exception of caspofungin (84.6%), where 10% of the results were categorized as non-WT by the EUCAST method and WT by the CLSI method. Problem areas with low EA or CA include testing of amphotericin B, anidulafungin, and isavuconazole against C. glabrata, itraconazole, and posaconazole against most species, and caspofungin against C. parapsilosis, C. tropicalis, and C. krusei. We confirm high level EA and CA (>90%) between the 2 methods for testing fluconazole, voriconazole, and micafungin against all 5 species. The results indicate that the EUCAST and CLSI methods produce comparable results for testing the systemically active antifungal agents against the 5 most common species of Candida; however, there are several areas where additional

  11. The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics

    Directory of Open Access Journals (Sweden)

    Ingrid Evans-Osses

    2013-01-01

    Full Text Available The innate immune system is evolutionary and ancient and is the pivotal line of the host defense system to protect against invading pathogens and abnormal self-derived components. Cellular and molecular components are involved in recognition and effector mechanisms for a successful innate immune response. The complement lectin pathway (CLP was discovered in 1990. These new components at the complement world are very efficient. Mannan-binding lectin (MBL and ficolin not only recognize many molecular patterns of pathogens rapidly to activate complement but also display several strategies to evade innate immunity. Many studies have shown a relation between the deficit of complement factors and susceptibility to infection. The recently discovered CLP was shown to be important in host defense against protozoan microbes. Although the recognition of pathogen-associated molecular patterns by MBL and Ficolins reveal efficient complement activations, an increase in deficiency of complement factors and diversity of parasite strategies of immune evasion demonstrate the unsuccessful effort to control the infection. In the present paper, we will discuss basic aspects of complement activation, the structure of the lectin pathway components, genetic deficiency of complement factors, and new therapeutic opportunities to target the complement system to control infection.

  12. Development of an in vitro macrophage system to assess Penicillium marneffei growth and susceptibility to nitric oxide.

    Science.gov (United States)

    Cogliati, M; Roverselli, A; Boelaert, J R; Taramelli, D; Lombardi, L; Viviani, M A

    1997-01-01

    We investigated the effect of nitric oxide (NO) and reactive nitrogen intermediates on the in vitro growth of Penicillium marneffei both in a cell-free system and in a novel macrophage culture system. In the cell-free system, NO that was chemically generated from NaNO2 in acid media (pH 4 and 5) markedly inhibited the growth of P. marneffei. On the contrary, inhibition of growth did not occur in neutral medium (pH 7.4) in which NO was not produced. P. marneffei conidia were phagocytized by nonstimulated murine J774 macrophages after 2 h of incubation. During the following 24 h, P. marneffei grew as yeast-like cells replicating by fission in the J774 macrophages. The intracellular growth of P. marneffei damaged nonstimulated J774 macrophages, as confirmed by electron microscopy. When J774 cells were stimulated by gamma interferon and lipopolysaccharide, which led to enhanced production of reactive nitrogen intermediates, the percentage of yeast-like cells was significantly reduced and P. marneffei conidia were damaged in the J774 macrophages. The inhibition of NO synthesis by N-monomethyl-L-arginine restored the intracellular growth of P. marneffei. The inverse correlation between intramacrophage growth and the amount of nitrite detected in culture supernatants supports the hypothesis that the L-arginine-dependent NO pathway plays an important role in the murine macrophage immune response against P. marneffei.

  13. Minnesota logging utilization factors, 1975-1976--development, use, implications.

    Science.gov (United States)

    James E. Blyth; W. Brad Smith

    1979-01-01

    Discusses Minnesota saw log and pulpwood logging utilization factors developed during 1975-1976 and their implications. Compares factors for several species groups and shows their use in estimating growing stock cut for pulpwood and saw logs.

  14. Unconventional neutron sources for oil well logging

    Energy Technology Data Exchange (ETDEWEB)

    Frankle, C.M., E-mail: cfrankle@lanl.gov; Dale, G.E.

    2013-09-21

    Americium–Beryllium (AmBe) radiological neutron sources have been widely used in the petroleum industry for well logging purposes. There is strong desire on the part of various governmental and regulatory bodies to find alternate sources due to the high activity and small size of AmBe sources. Other neutron sources are available, both radiological ({sup 252}Cf) and electronic accelerator driven (D–D and D–T). All of these, however, have substantially different neutron energy spectra from AmBe and thus cause significantly different responses in well logging tools. We report on simulations performed using unconventional sources and techniques to attempt to better replicate the porosity and carbon/oxygen ratio responses a well logging tool would see from AmBe neutrons. The AmBe response of these two types of tools is compared to the response from {sup 252}Cf, D–D, D–T, filtered D–T, and T–T sources. -- Highlights: • AmBe sources are widely used for well logging purposes. • Governmental bodies would prefer to minimize AmBe use. • Other neutron sources are available, both radiological and electronic. • Tritium–tritium spectrum neutrons have similar logging tool response to AmBe. • A tritium–tritium neutron generator may be a viable AmBe replacement.

  15. AML (Advanced Mud Logging: First Among Equals

    Directory of Open Access Journals (Sweden)

    T. Loermans

    2017-09-01

    Full Text Available During the past ten years an enormous development in mud logging technology has been made. Traditional mud logging was only qualitative in nature, and mudlogs could not be used for the petrophysical well evaluations which form the basis for all subsequent activities on wells and fields. AML however can provide quantitative information, logs with a reliability, trueness and precision like LWD and WLL. Hence for well evaluation programmes there are now three different logging methods available, each with its own pros and cons on specific aspects: AML, LWD and WLL. The largest improvements have been made in mud gas analysis and elemental analysis of cuttings. Mud gas analysis can yield hydrocarbon fluid composition for some components with a quality like PVT analysis, hence not only revolutionising the sampling programme so far done with only LWD/WLL, but also making it possible to geosteer on fluid properties. Elemental analysis of cuttings, e.g. with XRF, with an ability well beyond the capabilities of the spectroscopy measurements possible earlier with LWD/WLL tools, is opening up improved ways to evaluate formations, especially of course where the traditional methods are falling short of requirements, such as in unconventional reservoirs. An overview and specific examples of these AML logs is given, from which it may be concluded that AML now ought to be considered as “first among its equals”.

  16. Developing Surveillance Methodology for Agricultural and Logging Injury in New Hampshire Using Electronic Administrative Data Sets.

    Science.gov (United States)

    Scott, Erika E; Hirabayashi, Liane; Krupa, Nicole L; Sorensen, Julie A; Jenkins, Paul L

    2015-08-01

    Agriculture and logging rank among industries with the highest rates of occupational fatality and injury. Establishing a nonfatal injury surveillance system is a top priority in the National Occupational Research Agenda. Sources of data such as patient care reports (PCRs) and hospitalization data have recently transitioned to electronic databases. Using narrative and location codes from PCRs, along with International Classification of Diseases, 9th Revision, external cause of injury codes (E-codes) in hospital data, researchers are designing a surveillance system to track farm and logging injury. A total of 357 true agricultural or logging cases were identified. These data indicate that it is possible to identify agricultural and logging injury events in PCR and hospital data. Multiple data sources increase catchment; nevertheless, limitations in methods of identification of agricultural and logging injury contribute to the likely undercount of injury events.

  17. Search Log Analysis of the ARTstor Cultural Heritage Image Database

    OpenAIRE

    Lowe, Heather Ann

    2013-01-01

    Search log studies are widely used to gain an understanding of how users interact with an information resource. However, of the studies that examine image databases, the information systems studied are image sites, local collections or general web engines. Few if any studies examine the way users search within a general art and cultural heritage image database. This thesis seeks to discover the types of queries users submit, whether these change over time, and if these differ depending on the...

  18. Mining ticketing logs for usage characterization with nonnegative matrix factorization

    OpenAIRE

    Poussevin, Mickaël; Baskiotis, Nicolas; Guigue, Vincent; Gallinari, Patrick

    2014-01-01

    International audience; Understanding urban mobility is a fundamental question for institutional organizations (transport authorities, city halls) and it involves many different fields like social sciences, urbanism or geography. With the increasing number of probes tracking human locations, like magnetic pass for urban transportation, road sensors, CCTV systems or cell phones, mobility data are exponentially growing. Mining the activity logs in order to model and characterize efficiently our...

  19. Contrasting Roles of the Apoplastic Aspartyl Protease APOPLASTIC, ENHANCED DISEASE SUSCEPTIBILITY1-DEPENDENT1 and LEGUME LECTIN-LIKE PROTEIN1 in Arabidopsis Systemic Acquired Resistance.

    Science.gov (United States)

    Breitenbach, Heiko H; Wenig, Marion; Wittek, Finni; Jordá, Lucia; Maldonado-Alconada, Ana M; Sarioglu, Hakan; Colby, Thomas; Knappe, Claudia; Bichlmeier, Marlies; Pabst, Elisabeth; Mackey, David; Parker, Jane E; Vlot, A Corina

    2014-06-01

    Systemic acquired resistance (SAR) is an inducible immune response that depends on ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1). Here, we show that Arabidopsis (Arabidopsis thaliana) EDS1 is required for both SAR signal generation in primary infected leaves and SAR signal perception in systemic uninfected tissues. In contrast to SAR signal generation, local resistance remains intact in eds1 mutant plants in response to Pseudomonas syringae delivering the effector protein AvrRpm1. We utilized the SAR-specific phenotype of the eds1 mutant to identify new SAR regulatory proteins in plants conditionally expressing AvrRpm1. Comparative proteomic analysis of apoplast-enriched extracts from AvrRpm1-expressing wild-type and eds1 mutant plants led to the identification of 12 APOPLASTIC, EDS1-DEPENDENT (AED) proteins. The genes encoding AED1, a predicted aspartyl protease, and another AED, LEGUME LECTIN-LIKE PROTEIN1 (LLP1), were induced locally and systemically during SAR signaling and locally by salicylic acid (SA) or its functional analog, benzo 1,2,3-thiadiazole-7-carbothioic acid S-methyl ester. Because conditional overaccumulation of AED1-hemagglutinin inhibited SA-induced resistance and SAR but not local resistance, the data suggest that AED1 is part of a homeostatic feedback mechanism regulating systemic immunity. In llp1 mutant plants, SAR was compromised, whereas the local resistance that is normally associated with EDS1 and SA as well as responses to exogenous SA appeared largely unaffected. Together, these data indicate that LLP1 promotes systemic rather than local immunity, possibly in parallel with SA. Our analysis reveals new positive and negative components of SAR and reinforces the notion that SAR represents a distinct phase of plant immunity beyond local resistance. © 2014 American Society of Plant Biologists. All Rights Reserved.

  20. Microwave susceptibility experiments

    Energy Technology Data Exchange (ETDEWEB)

    McConaghy, C.

    1984-05-29

    In certain experimental environments, systems can be affected or damaged by microwave pulses. I have conducted tests at LLNL to understand the phenomenology of microwave susceptibility of system components and subsystem components. To date, my experiments have concentrated on bipolar transistors, similar to what might be used in discrete analog circuits, and on CMOS RAM chips, which might be used in a computer memory system. I observed a decrease in failure energies for both the transistor and the integrated curcuit as I shortened the microwave pulse width. An S band (2.86 GHz) transmit/receive (T/R) tube has also been tested both at S band and at X band (8.16 GHz). The S band pulse had limitations in rise-time from zero power, which had an effect on the amount of power that could be transmitted through the T/R tube, as much as 0.7% of the incident power passed through the tube. All tests were conducted in closed-waveguide or coax test-fixtures, in contrast to the anechoic chambers utilized by other experimenters. I have used both S band and X band Klystron generators. For very high power (greater than 1 MW), I used an additional pulse-compression cavity at S band. Other subsystem components such as an X band mixer and an X band T/R tube will be tested in the future. 8 references.

  1. Smartphone log data in a qualitative perspective

    DEFF Research Database (Denmark)

    Ørmen, Jacob; Thorhauge, Anne Mette

    2015-01-01

    Log data from smartphones have primarily been used in large-scale research designs to draw statistical inferences from hundreds or even thousands of participants. In this article, we argue that more qualitatively oriented designs can also benefit greatly from integrating these rich data sources...... serve as cues to instigate discussion and reflection as well as act as resources for contextualizing and organizing related empirical material. In the discussion, the advantages of a qualitative perspective for research designs are assessed in relation to issues of validity. Further perspectives...... into studies of smartphones in everyday life. Through an illustrative study, we explore a more nuanced perspective on what can be considered “log data” and how these types of data can be collected and analysed. A qualitative approach to log data analysis offers researchers new opportunities to situate...

  2. Narrating Illegal Logging Across the Globe

    DEFF Research Database (Denmark)

    Winkel, Georg; Leipold, Sina; Buhmann, Karin

    2017-01-01

    In the last decade illegal logging has triggered the attention of policy makers and scholars of international forest governance. The issue is multifaceted, involving aspects of social and environmental sustainability, development, trade, access to markets and competitiveness. A vivid academic...... debate has resulted, exploring the nexus between markets and trade on one hand, and environmental and social sustainability on the other. The purpose of this paper is systematically assess the international policy discourse on illegal logging and legality verification policies in different regions...... conversations with practitioners, policy documents and a media analysis. We find striking differences across the globe in narratives about illegal logging and legality verification and conclude that these need to be considered when assessing the support for, and the current and potential effects of...

  3. Benefit Analysis for Geothermal Log Interpretation

    Energy Technology Data Exchange (ETDEWEB)

    Rigby, F.A.

    1980-12-16

    Formation evaluation is of great importance in geothermal development because of the high capital costs and the fact that successful exploration will only pay off through a subsequent decision to construct a power plant or other utilization facility. Since much formation data is available from well logging, development of new techniques of log interpretation for application to geothermal wells is called for. An analysis of potential nearterm benefits from this program and the types of formation data called for is discussed. Much useful information can be developed by adaptation of techniques used in oil and gas reservoirs, but the different demands of geothermal development from hydrocarbon production also open up new data requirements.

  4. Perfil logístico de Colombia

    OpenAIRE

    Cardozo Maglioni, María Victoria; Lozano Suarez, María Goretty

    2012-01-01

    El presente documento ofrece un estudio del perfil logístico de Colombia con la finalidad de dar a conocer el estado de arte de las ciudades, puertos e infraestructura principal para facilitar la toma de decisiones de los empresarios. Para el desarrollo de este trabajo se determinaron a partir de un análisis competitivo del país; las principales ciudades y puertos; logrando establecer un inventario de maquinaria y equipo e infraestructura logística; enmarcados en retos ya establecidos en las ...

  5. Logística humanitaria: seguridad agroalimentaria

    OpenAIRE

    Goyes Lesmes, Jessica Andrea

    2016-01-01

    Actualmente la relación que existe entre la logística humanitaria y la seguridad agroalimentaria es muy estrecha, estos dos conceptos constituyen un elemento sumamente importante en situaciones que se presentan hoy en día a nivel mundial, como por ejemplo en los diferentes tipos de desastres naturales como terremotos, tsunamis, sequías, hambrunas, entre otros, o simplemente, en zonas de alta pobreza. La logística humanitaria es hoy en día un concepto novedoso que nace de la necesidad de p...

  6. Perfil logístico de Portugal

    OpenAIRE

    Rodríguez Páez, Johanna Marcela

    2014-01-01

    El presente documento ofrece un estudio del perfil logístico de Portugal, abarcando diferentes aspectos que afectan la competitividad y el desempeño de la cadena logística de un país, con la finalidad de conocer a uno de los socios comerciales con los cuáles Colombia se encuentra negociando, en este caso Portugal, uno de los 28 países que hace parte del reciente tratado de libre comercio aprobado con la Unión Europea, es preciso estudiar las ventajas competitivas que poseen dichos socios, a l...

  7. RAYSAW: a log sawing simulator for 3D laser-scanned hardwood logs

    Science.gov (United States)

    R. Edward. Thomas

    2013-01-01

    Laser scanning of hardwood logs provides detailed high-resolution imagery of log surfaces. Characteristics such as sweep, taper, and crook, as well as most surface defects, are visible to the eye in the scan data. In addition, models have been developed that predict interior knot size and position based on external defect information. Computerized processing of...

  8. Financial feasibility of a log sort yard handling small-diameter logs: A preliminary study

    Science.gov (United States)

    Han-Sup Han; E. M. (Ted) Bilek; John (Rusty) Dramm; Dan Loeffler; Dave Calkin

    2011-01-01

    The value and use of the trees removed in fuel reduction thinning and restoration treatments could be enhanced if the wood were effectively evaluated and sorted for quality and highest value before delivery to the next manufacturing destination. This article summarizes a preliminary financial feasibility analysis of a log sort yard that would serve as a log market to...

  9. Association of interleukin-10 promoter haplotypes with disease susceptibility and IL-10 levels in Mexican patients with systemic lupus erythematosus.

    Science.gov (United States)

    Palafox-Sánchez, Claudia Azucena; Oregon-Romero, Edith; Salazar-Camarena, Diana Celeste; Valle, Yeminia Maribel; Machado-Contreras, Jesús René; Cruz, Alvaro; Orozco-López, Mariana; Orozco-Barocio, Gerardo; Vázquez-Del Mercado, Mónica; Muñoz-Valle, José Francisco

    2015-11-01

    Systemic lupus erythematosus (SLE) is the prototype autoimmune rheumatic disease. The etiology of this disease is incompletely understood; however, environmental factors and genetic predisposition are involved. Cytokine-mediated immunity plays a crucial role in the pathogenesis of SLE. We investigate the association of interleukin-10 (IL-10) promoter polymorphisms and their haplotypes in SLE patients from the western Mexico. One hundred and twenty-five SLE patients fulfilling the 1997 ACR criteria and 260 unrelated healthy subjects (HS), both Mexican mestizos, were genotyped for IL-10 -1082A>G, -819C>T, and -592C>A polymorphisms. Haplotypes were inferred using the expectation-maximization algorithm, then allele and haplotype distributions were compared between patients and HS, as well as patients with different clinical variables. We identified at -1082, -819, and -592 four predominant haplotypes ACC (43.70 % in patients vs 46.55 % in HS), ATA (21.45 vs 22.97 %), GCC (16.28 vs 14.21 %), and GTA (14.12 vs 14.12 %). The ATC haplotype was more frequent in SLE respect to HS, suggesting a risk effect (3.23 vs 1.05 %; OR 3.55, CI 1.14-11.11; p = 0.0293). SLE patient carriers of -592 CC genotype as well as the dominant model of inheritance showed higher sIL-10 respect to AA genotype, suggesting that -592 C allele is associated with increased production of the cytokine (p IL-10 serum levels and higher values of Mexican version of the Systemic Lupus Erythematosus Disease Activity Index compared with the other haplotype carriers; however, no association was found regarding autoantibodies. Our data suggest that the IL-10 promoter haplotypes play an important role in the risk of developing SLE and influence the production of IL-10 in Mexican population. Nevertheless, further studies are required to analyze the expression of mRNA as well as to investigate the interacting epigenetic factors that could help to define the true contribution of this marker in SLE pathogenesis.

  10. Susceptibility to malignant hyperthermia

    NARCIS (Netherlands)

    Snoeck, Marcus Matheus Johannes

    2004-01-01

    In this thesis the author studied the diagnostic procedures for susceptibility to malignant hyperthermia (MH), with special emphasis upon refining the biological diagnostic test and improving protocols and guidelines for investigation of MH susceptibility. MH is a pharmacogenetic disease of skeletal

  11. 17-β Estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr−/− mice

    Science.gov (United States)

    Shelton, KA; Cline, JM; Cann, JA

    2013-01-01

    Objective To test the hypothesis that estrogen treatment in a radiation chimera mouse model of systemic lupus erythematosus (SLE) and atherosclerosis will increase SLE-associated atherosclerosis by increasing autoantibody production and inflammation. Methods We used a radiation chimera mouse model in which bone marrow from the polygenic B6.Sle1.2.3 model of SLE was transferred to the low density lipoprotein receptor knock out (LDLr−/−) model of atherosclerosis on a C57BL/6 background (Sle/LDLr−/−). Ovariectomized chimeric mice were treated for 10 weeks with either 5.6 ug/day of 17β-estradiol or placebo; outcomes included atherosclerosis plaque size, anti-dsDNA autoantibody production and renal pathology. Results Mean atherosclerosis plaque size was 67.4 ± 7.6% smaller in the estrogen treated group (patherosclerosis lesion size and either the renal histology score or UP:UC ratio in Sle/LDLr−/− mice. Conclusion These results indicate that 17β-estradiol is atheroprotective within the context of murine SLE independent of changes in serum cholesterol concentration, autoantibody concentration, or renal pathology. The SLE phenotype in Sle/LDLr−/− mice is not exacerbated by exogenous 17β-estradiol administration, and the reduced UP:UC ratio suggests a protective effect against lupus nephritis. PMID:23395521

  12. 17-β Estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr(-/-) mice.

    Science.gov (United States)

    Shelton, K A; Cline, J M; Cann, J A

    2013-04-01

    To test the hypothesis that estrogen treatment in a radiation chimera mouse model of systemic lupus erythematosus (SLE) and atherosclerosis will increase SLE-associated atherosclerosis by increasing autoantibody production and inflammation. We used a radiation chimera mouse model in which bone marrow from the polygenic B6.Sle1.2.3 model of SLE was transferred to the low density lipoprotein receptor knock out (LDLr(-/-)) model of atherosclerosis on a C57BL/6 background (Sle/LDLr(-/-)). Ovariectomized chimeric mice were treated for 10 weeks with either 5.6 μg/day of 17β-estradiol or placebo; outcomes included atherosclerosis plaque size, anti-dsDNA autoantibody production and renal pathology. Mean atherosclerosis plaque size was 67.4 ± 7.6% smaller in the estrogen treated group (p atherosclerosis lesion size and either the renal histology score or UP:UC ratio in Sle/LDLr(-/-) mice. These results indicate that 17β-estradiol is atheroprotective within the context of murine SLE independent of changes in serum cholesterol concentration, autoantibody concentration, or renal pathology. The SLE phenotype in Sle/LDLr(-/-) mice is not exacerbated by exogenous 17β-estradiol administration, and the reduced UP:UC ratio suggests a protective effect against lupus nephritis. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  13. Same day identification and full panel antimicrobial susceptibility testing of bacteria from positive blood culture bottles made possible by a combined lysis-filtration method with MALDI-TOF VITEK mass spectrometry and the VITEK2 system.

    Directory of Open Access Journals (Sweden)

    Alexandra Machen

    Full Text Available Rapid identification and antimicrobial susceptibility testing of microorganisms causing bloodstream infections or sepsis have the potential to improve patient care. This proof-of-principle study evaluates the Lysis-Filtration Method for identification as well as antimicrobial susceptibility testing of bacteria directly from positive blood culture bottles in a clinical setting. A total of 100 non-duplicated positive blood cultures were tested and 1012 microorganism-antimicrobial combinations were assessed. An aliquot of non-charcoal blood culture broth was incubated with lysis buffer briefly before being filtered and washed. Microorganisms recovered from the filter membrane were first identified by using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight VITEK® Mass Spectrometry (VITEK MS. After quick identification from VITEK MS, filtered microorganisms were inoculated to VITEK®2 system for full panel antimicrobial susceptibility testing analysis. Of 100 bottles tested, the VITEK MS resulted in 94.0% correct organism identification to the species level. Compared to the conventional antimicrobial susceptibility testing methods, direct antimicrobial susceptibility testing from VITEK®2 resulted in 93.5% (946/1012 category agreement of antimicrobials tested, with 3.6% (36/1012 minor error, 1.7% (7/1012 major error, and 1.3% (13/1012 very major error of antimicrobials. The average time to identification and antimicrobial susceptibility testing was 11.4 hours by using the Lysis-Filtration method for both VITEK MS and VITEK®2 compared to 56.3 hours by using conventional methods (p<0.00001. Thus, the same-day results of microorganism identification and antimicrobial susceptibility testing directly from positive blood culture can be achieved and can be used for appropriate antibiotic therapy and antibiotic stewardship.

  14. Comparison of individuals opting for BRCA1/2 or HNPCC genetic susceptibility testing with regard to coping, illness perceptions, illness experiences, family system characteristics and hereditary cancer distress

    NARCIS (Netherlands)

    van Oostrom, Iris; Meijers-Heijboer, Hanne; Duivenvoorden, Hugo J.; Bröcker-Vriends, Annette H. J. T.; van Asperen, Christi J.; Sijmons, Rolf H.; Seynaeve, Caroline; van Gool, Arthur R.; Klijn, Jan G. M.; Tibben, Aad

    2007-01-01

    To study differences between individuals opting for genetic cancer susceptibility testing of a known familial BRCA1/2 and HNPCC related germline mutation. Coping, illness perceptions, experiences with cancer in relatives and family system characteristics were assessed in 271 applicants for genetic

  15. Comparison of individuals opting for BRCA1/2 or HNPCC genetic susceptibility testing with regard to coping, illness perceptions, illness experiences, family system characteristics and hereditary cancer distress

    NARCIS (Netherlands)

    van Oostrom, Iris; Meijers-Heijboer, Hanne; Duivenvoorden, Hugo J.; Brocker-Vriends, Annette H. J. T.; van Asperen, Christi J.; Sijmons, Rolf H.; Seynaeve, Caroline; Van Gool, Arthur R.; Klijn, Jan G. M.; Tibben, Aad

    Objective: To study differences between individuals opting for genetic cancer susceptibility testing of a known familial BRCA1/2 and HNPCC related germline mutation. Methods: Coping, illness perceptions, experiences with cancer in relatives and family system characteristics were assessed in 271

  16. Comparison of individuals opting for BRCA1/2 or HNPCC genetic susceptibility testing with regard to coping, illness perceptions, illness experiences, family system characteristics and hereditary cancer distress.

    NARCIS (Netherlands)

    Oostrom, I.I.H. van; Meijers-Heijboer, H.; Duivenvoorden, H.J.; Brocker-Vriends, A.H.; Asperen, C.J. van; Sijmons, R.H.; Seynaeve, C.; Gool, A.R. van; Klijn, J.G.M.; Tibben, A.

    2007-01-01

    OBJECTIVE: To study differences between individuals opting for genetic cancer susceptibility testing of a known familial BRCA1/2 and HNPCC related germline mutation. METHODS: Coping, illness perceptions, experiences with cancer in relatives and family system characteristics were assessed in 271

  17. Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.

    Directory of Open Access Journals (Sweden)

    Jian Zhao

    2011-05-01

    Full Text Available Systemic lupus erythematosus (SLE, a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH and five CFH-related proteins (CFHR1-CFHR5 within the chromosome 1q32 locus linked to SLE, have been associated with multiple human diseases and may contribute to dysregulated complement activation predisposing to SLE. We assessed 60 SNPs covering the CFH-CFHRs region for association with SLE in 15,864 case-control subjects derived from four ethnic groups. Significant allelic associations with SLE were detected in European Americans (EA and African Americans (AA, which could be attributed to an intronic CFH SNP (rs6677604, in intron 11, P(meta = 6.6×10(-8, OR = 1.18 and an intergenic SNP between CFHR1 and CFHR4 (rs16840639, P(meta = 2.9×10(-7, OR = 1.17 rather than to previously identified disease-associated CFH exonic SNPs, including I62V, Y402H, A474A, and D936E. In addition, allelic association of rs6677604 with SLE was subsequently confirmed in Asians (AS. Haplotype analysis revealed that the underlying causal variant, tagged by rs6677604 and rs16840639, was localized to a ~146 kb block extending from intron 9 of CFH to downstream of CFHR1. Within this block, the deletion of CFHR3 and CFHR1 (CFHR3-1Δ, a likely causal variant measured using multiplex ligation-dependent probe amplification, was tagged by rs6677604 in EA and AS and rs16840639 in AA, respectively. Deduced from genotypic associations of tag SNPs in EA, AA, and AS, homozygous deletion of CFHR3-1Δ (P(meta = 3.2×10(-7, OR = 1.47 conferred a higher risk of SLE than heterozygous deletion (P(meta = 3.5×10(-4, OR = 1.14. These results suggested that the CFHR3-1Δ deletion within the SLE-associated block, but not the previously described exonic SNPs of CFH, might contribute to the development of SLE in EA, AA, and AS, providing new insights into the role of

  18. Novel Desorber for Online Drilling Mud Gas Logging.

    Science.gov (United States)

    Lackowski, Marcin; Tobiszewski, Marek; Namieśnik, Jacek

    2016-01-01

    This work presents the construction solution and experimental results of a novel desorber for online drilling mud gas logging. The traditional desorbers use mechanical mixing of the liquid to stimulate transfer of hydrocarbons to the gaseous phase that is further analyzed. The presented approach is based on transfer of hydrocarbons from the liquid to the gas bubbles flowing through it and further gas analysis. The desorber was checked for gas logging from four different drilling muds collected from Polish boreholes. The results of optimization studies are also presented in this study. The comparison of the novel desorber with a commercial one reveals strong advantages of the novel one. It is characterized by much better hydrocarbons recovery efficiency and allows reaching lower limits of detection of the whole analytical system. The presented desorber seems to be very attractive alternative over widely used mechanical desorbers.

  19. Novel Desorber for Online Drilling Mud Gas Logging

    Directory of Open Access Journals (Sweden)

    Marcin Lackowski

    2016-01-01

    Full Text Available This work presents the construction solution and experimental results of a novel desorber for online drilling mud gas logging. The traditional desorbers use mechanical mixing of the liquid to stimulate transfer of hydrocarbons to the gaseous phase that is further analyzed. The presented approach is based on transfer of hydrocarbons from the liquid to the gas bubbles flowing through it and further gas analysis. The desorber was checked for gas logging from four different drilling muds collected from Polish boreholes. The results of optimization studies are also presented in this study. The comparison of the novel desorber with a commercial one reveals strong advantages of the novel one. It is characterized by much better hydrocarbons recovery efficiency and allows reaching lower limits of detection of the whole analytical system. The presented desorber seems to be very attractive alternative over widely used mechanical desorbers.

  20. 47 CFR 80.409 - Station logs.

    Science.gov (United States)

    2010-10-01

    ... primary office or available to the Commission via secured access to the licensee's Internet web site. Logs... which may affect the proper operation of the station. The entry must be made, dated and in the case of a... occurrences which may appear to be of importance to safety of life or property at sea, must be entered...

  1. Apache Flume distributed log collection for Hadoop

    CERN Document Server

    D'Souza, Subas

    2013-01-01

    A starter guide that covers Apache Flume in detail.Apache Flume: Distributed Log Collection for Hadoop is intended for people who are responsible for moving datasets into Hadoop in a timely and reliable manner like software engineers, database administrators, and data warehouse administrators

  2. Changes in the Logging Labor Force

    Science.gov (United States)

    Charles H. Wolf; Jean W. Nolley

    1977-01-01

    Employment in the logging industry dropped 28 percent between 1950 and 1970, while output of industrial roundwood increased 31 percent. Today's loggers are older, better educated, and more skilled. A large proportion are self-employed, many work less than a full year, and a substantial number have incomes below the poverty level. Mechanization of timber harvesting...

  3. 29 CFR 1918.88 - Log operations.

    Science.gov (United States)

    2010-07-01

    ... protected by a personal flotation device meeting the requirements of § 1918.105(b)(2). (c) Footwear. The employer shall provide each employee that is working logs with appropriate footwear, such as spiked shoes or caulked sandals, and shall ensure that each employee wears appropriate footwear to climb or walk...

  4. Predicting reservoir wettability via well logs

    Science.gov (United States)

    Feng, Cheng; Fu, Jinhua; Shi, Yujiang; Li, Gaoren; Mao, Zhiqiang

    2016-06-01

    Wettability is an important factor in controlling the distribution of oil and water. However, its evaluation has so far been a difficult problem because no log data can directly indicate it. In this paper, a new method is proposed for quantitatively predicting reservoir wettability via well log analysis. Specifically, based on the J function, diagenetic facies classification and the piecewise power functions, capillary pressure curves are constructed from conventional logs and a nuclear magnetic resonance (NMR) log respectively. Under the influence of wettability, the latter is distorted while the former remains unaffected. Therefore, the ratio of the median radius obtained from the two kinds of capillary pressure curve is calculated to reflect wettability, a quantitative relationship between the ratio and reservoir wettability is then established. According to the low-permeability core sample capillary pressure curve, NMR {{T}2} spectrum and contact angle experimental data from the bottom of the Upper Triassic reservoirs in western Ordos Basin, China, two kinds of constructing capillary pressure curve models and a predictive wettability model are calibrated. The wettability model is verified through the Amott wettability index and saturation exponent from resistivity measurement and their determined wettability levels are comparable, indicating that the proposed model is quite reliable. In addition, the model’s good application effect is exhibited in the field study. Thus, the quantitatively predicting reservoir wettability model proposed in this paper provides an effective tool for formation evaluation, field development and the improvement of oil recovery.

  5. Lianas and logging in West Africa

    NARCIS (Netherlands)

    Parren, M.P.E.

    2003-01-01

    The role of lianas in relation to logging activities is analysed in a lowland moist forest in Cameroon. Lianas are an abundant, diverse, and conspicuous growth form in nearly all tropical forests. Lianas are mostly seen as a nuisance by foresters. Cutting of liana stems is an important operation in

  6. Alaska midgrade logs: supply and offshore demand.

    Science.gov (United States)

    Donald F. Flora; Wendy J. McGinnis

    1989-01-01

    The outlook for shipments and prices of export logs from Alaska differs significantly by grade (quality class). For the majority lying in the middle of the value range, the trend of prices is projected to increase $200 per thousand board feet, or about 55 percent, by 2000. Shipments are expected to rise about 30 percent by 1995 and then subside about 10 percent. These...

  7. Analyzing Grid Log Data with Affinity Propagation

    NARCIS (Netherlands)

    Modena, G.; van Someren, M.W.; Ali, M; Bosse, T.; Hindriks, K.V.; Hoogendoorn, M.; Jonker, C.M; Treur, J.

    2013-01-01

    In this paper we present an unsupervised learning approach to detect meaningful job traffic patterns in Grid log data. Manual anomaly detection on modern Grid environments is troublesome given their increasing complexity, the distributed, dynamic topology of the network and heterogeneity of the jobs

  8. Narrating Illegal Logging Across the Globe

    DEFF Research Database (Denmark)

    Winkel, Georg; Leipold, Sina; Buhmann, Karin

    2017-01-01

    In the last decade illegal logging has triggered the attention of policy makers and scholars of international forest governance. The issue is multifaceted, involving aspects of social and environmental sustainability, development, trade, access to markets and competitiveness. A vivid academic deb...

  9. High temperature spectral gamma well logging

    Energy Technology Data Exchange (ETDEWEB)

    Normann, R.A.; Henfling, J.A.

    1997-01-01

    A high temperature spectral gamma tool has been designed and built for use in small-diameter geothermal exploration wells. Several engineering judgments are discussed regarding operating parameters, well model selection, and signal processing. An actual well log at elevated temperatures is given with spectral gamma reading showing repeatability.

  10. Multiscale Visualization of Dynamic Software Logs

    NARCIS (Netherlands)

    Moreta, Sergio; Telea, Alexandru

    2007-01-01

    We present a set of techniques and design principles for the visualization of large dynamic software logs consisting of attributed change events, such as obtained from instrumenting programs or mining software repositories. We enhance the visualization scalability with importance-based antialiasing

  11. Potential for shared log transport services

    Science.gov (United States)

    Tim McDonald; Steve Taylor; Jorge Valenzuela

    2001-01-01

    A simulation model of a log transport logistics network was developed. The model could be structured to either share truck capacity among a group of loggers, or to assign a fixed number of trucks to individual loggers. Another variation of the model allowed the use of a staging yard to set out loaded trailers and deliver them to destinations using dedicated shuttle...

  12. SNG-log in borehole Ermelund-208

    DEFF Research Database (Denmark)

    Korsbech, Uffe C C

    1996-01-01

    A Spectral Natural Gamma-ray log has been run in a borehole in Ermelunden. The vertical distribution of Th, U, and K is similar to that observed in neighbouring boreholes. A new measuring and data processing technique was used and the probes own background signal was determined. Surprisingly...

  13. Analysis of a double steering forest trailer for long wood log transportation

    Directory of Open Access Journals (Sweden)

    Francesco Marinello

    2013-09-01

    Full Text Available A cost effective technical solution of a forest double steering trailer was studied and tested, allowing decrease of radius of curvature and increase of the maneuverability, independently from the length of the transported logs. The steering system improves the so called “stingertype truck” configuration using an articulated frame; through a rearward hinge, the front wheels direction mechanically controls and adapts the direction of rear twin wheels. The study was based on CAD simulations considering the dimensions of the trailer transporting logs with a length up to 12 m. For different log lengths the simulation analyzed the total maneuver area, in terms of minimum curve radius and curve widening. A field test on a prototype operated for transport of long logs along a representative forest road in the Alps was carried out. The results confirm the improvements foreseen by CAD simulations, with allowed curve radius down to 6 m, even with 12 m logs.

  14. Direct blood culturing on solid medium outperforms an automated continuously monitored broth-based blood culture system in terms of time to identification and susceptibility testing

    Directory of Open Access Journals (Sweden)

    E.A. Idelevich

    2016-03-01

    Full Text Available Pathogen identification and antimicrobial susceptibility testing (AST should be available as soon as possible for patients with bloodstream infections. We investigated whether a lysis-centrifugation (LC blood culture (BC method, combined with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS identification and Vitek 2 AST, provides a time advantage in comparison with the currently used automated broth-based BC system. Seven bacterial reference strains were added each to 10 mL human blood in final concentrations of 100, 10 and 1 CFU/mL. Inoculated blood was added to the Isolator 10 tube and centrifuged at 3000 g for 30 min, then 1.5 mL sediment was distributed onto five 150-mm agar plates. Growth was observed hourly and microcolonies were subjected to MALDI-TOF MS and Vitek 2 as soon as possible. For comparison, seeded blood was introduced into an aerobic BC bottle and incubated in the BACTEC 9240 automated BC system. For all species/concentration combinations except one, successful identification and Vitek 2 inoculation were achieved even before growth detection by BACTEC. The fastest identification and inoculation for AST were achieved with Escherichia coli in concentrations of 100 CFU/mL and 10 CFU/mL (after 7 h each, while BACTEC flagged respective samples positive after 9.5 h and 10 h. Use of the LC-BC method allows skipping of incubation in automated BC systems and, used in combination with rapid diagnostics from microcolonies, provides a considerable advantage in time to result. This suggests that the usefulness of direct BC on solid medium should be re-evaluated in the era of rapid microbiology.

  15. Surgical Case Logging Habits and Attitudes: A Multispecialty Survey of Residents.

    Science.gov (United States)

    Cadish, Lauren A; Fung, Vicki; Lane, Felicia L; Campbell, Eric G

    2016-01-01

    The Accreditation Council for Graduate Medical Education measures surgical residents' experience in the United States by mandating that residents log each procedure in which they have participated. This system is the primary mechanism by which breadth and depth of surgical training are documented, and data are used for program accreditation and by individual program directors to assess resident preparedness. The study objective was to learn from residents across surgical specialties how this system is being used, and whether they believe these data are reliable. Investigators developed and administered a voluntary, 45-item survey. Resident demographic data, program details, logging behaviors, and attitudes were examined using descriptive statistics. Authors used multivariate logistic regression to assess respondent and program characteristics associated with logging habits. The survey was administered at a large academic medical center. All general surgery, obstetrics and gynecology, orthopedics, urology, neurosurgery, otolaryngology, and plastic surgery residents were eligible. Of 126 surgical residents, 82 participated, yielding a response rate of 65%. Overall, 7.5% considered the case log system highly inaccurate, 28.8% somewhat inaccurate, 52.5% somewhat accurate, and 11.3% highly accurate. Nearly half (48.1%) use an incorrect metric to log their role as surgeon or assistant. Half logged monthly or less frequently. The longest time residents reported falling behind ranged from less than a week to more than a year, with about half (51.4%) reporting backlogs of 3 months or longer. Approximately two-thirds considered the system difficult to navigate (64.2%) and burdensome (68.8%). Departmental training and reminders to log were associated with high fidelity logging habits. Inconsistency of logging habits and perceived lack of accuracy raise concerns about use of the system for assessing surgical preparedness or accrediting training programs. Academic departments

  16. Remote Sensing and Geographic Information Systems (GIS Contribution to the Inventory of Infrastructure Susceptible to Earthquake and Flooding Hazards in North-Eastern Greece

    Directory of Open Access Journals (Sweden)

    Ioanna Papadopoulou

    2012-09-01

    Full Text Available For civil protection reasons there is a strong need to improve the inventory of areas that are more vulnerable to earthquake ground motions or to earthquake-related secondary effects, such as landslides, liquefaction or soil amplifications. The use of remote sensing and Geographic Information Systems (GIS methods along with the related geo-databases can assist local and national authorities to be better prepared and organized. Remote sensing and GIS techniques are investigated in north-eastern Greece in order to contribute to the systematic, standardized inventory of those areas that are more susceptible to earthquake ground motions, to earthquake-related secondary effects and to tsunami-waves. Knowing areas with aggregated occurrence of causal (“negative” factors influencing earthquake shock and, thus, the damage intensity, this knowledge can be integrated into disaster preparedness and mitigation measurements. The evaluation of satellite imageries, digital topographic data and open source geodata contributes to the acquisition of the specific tectonic, geologic and geomorphologic settings influencing local site conditions in an area and, thus, estimate possible damage to be suffered.

  17. Warehousing and transportation logistics of mango in Colombia: A system dynamics model/Logística en almacenamiento y transporte de mango en Colombia: Un modelo en dinámica de sistemas/Logística em armazenamento e transporte de manga na Colômbia: Um modelo em dinâmica de sistemas

    National Research Council Canada - National Science Library

    Javier Arturo Orjuela-Castro; Milton Mauricio Herrera-Ramírez; Wilson Adarme-Jaimes

    2017-01-01

    ... of inventory, transportation, and quality. A system dynamics model was proposed based on the literature review on inventory and transportation logistics, the studies on asymmetries in supply chain, packing, and packaging, and the results...

  18. Multiple Genetic Analysis System-Based Antibiotic Susceptibility Testing in Helicobacter pylori and High Eradication Rate With Phenotypic Resistance-Guided Quadruple Therapy.

    Science.gov (United States)

    Dong, Fangyuan; Ji, Danian; Huang, Renxiang; Zhang, Fan; Huang, Yiqin; Xiang, Ping; Kong, Mimi; Nan, Li; Zeng, Xianping; Wu, Yong; Bao, Zhijun

    2015-11-01

    Antibiotics resistance in Helicobacter pylori (H. pylori) is the major factor for eradication failure. Molecular tests including fluorescence in situ hybridization, PCR-restriction fragment length polymorphism, and dual priming oligonucleotide-PCR (DPO-PCR) play critical roles in the detection of antibiotic susceptibility; however, limited knowledge is known about application of multiple genetic analysis system (MGAS) in the area of H. pylori identification and antibiotics resistance detection.The aim of this study is to determine the antibiotics resistance using different molecular tests and evaluate the treatment outcomes of E-test-based genotypic resistance.A total of 297 patients with dyspepsia complaint were recruited for gastroscopies. Ninety patients with H. pylori culture positive were randomly divided into 2 groups (test group and control group). E-test, general PCR, and MGAS assay were performed in test group. Patients in control group were treated with empirical therapy (rabeprazole + bismuth potassium citrate + amoxicillin [AMX] + clarithromycin [CLR]), whereas patients in test group received quadruple therapy based on E-test results twice daily for 14 consecutive days. The eradication effect of H. pylori was confirmed by C-urea breath test after at least 4 weeks when treatment was finished.Rapid urease test showed 46.5% (128/297) patients with H. pylori infection, whereas 30.3% (90/297) patients were H. pylori culture positive. E-test showed that H. pylori primary resistance rate to CLR, AMX, metronidazole, tetracycline, and levofloxacin (LVX) was 40.0% (18/45), 4.4% (2/45), 53.3% (24/45), 0% (0/45), and 55.6% (25/45), respectively. In addition, there are many multidrug resistant (MDR) phenotypes, and the MDR strains have higher minimum inhibitory concentration than their single-drug resistant counterparts. Considering E-test as the reference test, the sensitivities of general PCR and MGAS in detecting CLR resistance were 83.3% (15/18) and 94.4% (17

  19. Evaluation of a direct method for the identification and antibiotic susceptibility assessment of microrganisms isolated from blood cultures by automatic systems

    Directory of Open Access Journals (Sweden)

    Sergio Frugoni

    2008-03-01

    Full Text Available The purpose of blood cultures in the septic patient is to address a correct therapeutic approach. Identification and antibiotic susceptibility test carried out directly from the bottle may give important information in short time.The introduction of the automatic instrumentation has improved the discovering of pathogens in the blood, however the elapsing time between the positive detection and the microbiological report is still along. Is the evaluation of this study a fast, easy, cheap method to be applied to the routine, which could reduce the response time in the bacteraemia diagnosis.The automatic systems Vitek Senior (bioMérieux, and Vitek 2 (bioMérieux were used at Pio Albergo Trivulzio (Centre1 and at Istituto dei Tumori (Centre2 respectivetly.To remove blood cells, 7 ml. of the culture has been moved by vacuum sampling in a test tube and centrifuged for 10 minutes at 1000 rpm the supernatant has been further centrifuged for 10 minutes at 3000 rpm.0.5 ml. of BHI has been added to the pellet o sediment.The concentration of bacterial suspension has been fit for the inoculation. At the same time has been prepared standard cultures in suitable culture media were carried out for comparison. In the centro1 and centro2 have been isolated and identify respectively 63 and 31 Gram negative, and, 32 and 40 gram positive microorganisms have been isolated and identify in the Centre1 and Centre2 respectively.The identification Gram-negative and Gram positive microorganisms showed an agreement of 100% and 86.2% and 93.3% and 65.78% respectively between the direct and the standard method. For antibiotic susceptibility tests, 903 (Centre1 and 491 (Centre2 and 396 and 509 compounds were totally assessed in Gram negative and Gram positive bacteria respectively.The analysis has highlighted that: Centre1 has reported 0.30% very major errors (GE, 0.92% major errors (EM, 1.23% minor errors (Em. Centre 2 showed 0.57% very major errors (GE, 0.09% major errors

  20. A rapid method for the determination of microbial susceptibility using the firefly luciferase assay for adenosine triphosphate (ATP)

    Science.gov (United States)

    Vellend, H.; Tuttle, S. A.; Barza, M.; Weinstein, L.; Picciolo, G. L.; Chappelle, E. W.

    1975-01-01

    Luciferase assay for adenosine triphosphate (ATP) was optimized for pure bacteria in broth in order to evaluate if changes in bacterial ATP content could be used as a rapid measure of antibiotic effect on microorganisms. Broth cultures of log phase bacteria were incubated at 310 K (37 C) for 2.5 hours at antimicrobial concentrations which resulted in the best discrimination between sensitive and resistant strains. Eighty-seven strains of 11 bacterial species were studied for their susceptibility to 12 commonly used antimicrobial agents: ampicillin, Penicillin G, nafcillin, carbenicillin, cephalothin, tetracycline, erythromycin, clindamycin, gentamicin, nitrofurantoin, colistin, and chloramplenicol. The major advantage of the ATP system over existing methods of rapid microbial susceptibility testing is that the assay can be made specific for bacterial ATP.

  1. Stress wave sorting of red maple logs for structural quality

    Science.gov (United States)

    Xiping Wang; Robert J. Ross; David W. Green; Brian Brashaw; Karl Englund; Michael Wolcott

    2004-01-01

    Existing log grading procedures in the United States make only visual assessments of log quality. These procedures do not incorporate estimates of the modulus of elasticity (MOE) of logs. It is questionable whether the visual grading procedures currently used for logs adequately assess the potential quality of structural products manufactured from them, especially...

  2. Veneer Log Production and Receipts in the Southeast, 1969

    Science.gov (United States)

    Richard L. Welch

    1971-01-01

    In 1969, production of veneer logs was almost 657 million board feet in the Southeast, while receipts of domestic logs at the 136 mills in the area were over 690 million board feet. Pine log production now amounts to 40 percent of the total, while hardwood log production is down 17 percent from that of 1963.

  3. Anomalous self potential (sp) log signatures observed in a water ...

    African Journals Online (AJOL)

    Geophysical logging was done after drilling had been completed in a water well at Okwudor, South Eastern Nigeria. Three electric logs were run viz: Self Potential (SP), Resistivity N16″ and N64″ logs. An anomaly was observed in the SP log. The SP results from this well show some deviation from the standard norm.

  4. Downhole Logging Measurements from IODP Expedition 313: an Overview and Future Directions

    Science.gov (United States)

    Inwood, J.; Lofi, J.; Scienceparty, E.

    2009-12-01

    Downhole geophysical measurements and images allow the characterization of the lithology and physical properties of the subsurface, thus making a powerful contribution to the evaluation of facies and sediment composition and to the recognition of key surfaces in siliciclastic successions. The mission-specific IODP Expedition 313 (May-July 2009) cored and logged sequences deposited on the New Jersey continental margin during the post-Eocene ice-house world. One of the aims of the Expedition is to evaluate sequence stratigraphic facies models that predict depositional environments, sediment compositions, and stratal geometries in response to sea-level change. 5800 m of wireline logging data were collected in three boreholes drilled to a composite total of 2062 m; here we present an overview of these data. Continuous through-pipe spectral gamma ray logs were acquired in each borehole and repeated in open hole intervals for calibration. Magnetic susceptibility, resistivity, sonic and acoustic image logs were obtained in open hole at key intervals and/or where borehole conditions allowed. Due to space limitations on the offshore platform, Exp313 cores were not split. Samples from core catchers, whole-round multi-sensor track measurements, vertical seismic profiles and these logging data comprise the full data set at the time of this writing. Preliminary analysis shows lateral and vertical changes in the physical properties of the sediments that enable us to distinguish depositional intervals at several scales (cms - tens of meters). Medium to high resolution acoustic images of the borehole walls reveal sedimentary characteristics even within intervals of low core recovery, and provide an accurate core-depth positioning of some key surfaces. Likewise, the continuous spectral gamma logs allow assessment of lithologies in intervals with incomplete core recovery, and show great promise of providing excellent log-core-seismic correlations once the cores are split and fully

  5. Log analysis to understand medical professionals' image searching behaviour.

    Science.gov (United States)

    Tsikrika, Theodora; Müller, Henning; Kahn, Charles E

    2012-01-01

    This paper reports on the analysis of the query logs of a visual medical information retrieval system that provides access to radiology resources. Our analysis shows that, despite sharing similarities with general Web search and also with biomedical text search, query formulation and query modification when searching for visual biomedical information have unique characteristics that need to be taken into account in order to enhance the effectiveness of the search support offered by such systems. Typical information needs of medical professionals searching radiology resources are also identified with the goal to create realistic search tasks for a medical image retrieval evaluation benchmark.

  6. Saponin promotes rapid identification and antimicrobial susceptibility profiling of Gram-positive and Gram-negative bacteria in blood cultures with the Vitek 2 system.

    Science.gov (United States)

    Lupetti, A; Barnini, S; Morici, P; Ghelardi, E; Nibbering, P H; Campa, M

    2013-04-01

    The rapid identification and antimicrobial susceptibility testing (AST) of bacteria in clinical blood cultures is crucial to optimise antimicrobial therapy. A previous study involving small sample numbers revealed that the addition of saponin to blood cultures, further referred to as the new method, shortened considerably the turn-around time for the identification and AST of Gram-positive cocci as compared to the current method involving an overnight subculture. Here, we extend previous results and compare the identification and AST of blood cultures containing Gram-negative bacilli by the new and current methods. The identification and AST of 121 Gram-positive and 109 Gram-negative bacteria in clinical monomicrobial blood cultures by the new and current methods and, in the case of Gram-negative bacilli, by direct (no additions) inoculation into an automated system (rapid method) was assessed using the Vitek 2 system. Discrepancies between the results obtained with the different methods were solved by manual methods. The new method correctly identified 88 % of Gram-positive and 98 % of Gram-negative bacteria, and the rapid method correctly identified 94 % of Gram-negative bacteria. The AST for all antimicrobials by the new method were concordant with the current method for 55 % and correct for an additional 9 % of Gram-positive bacteria, and concordant with the current method for 62 % and correct for an additional 21 % of Gram-negative bacilli. The AST by the rapid method was concordant with the current method for 62 % and correct for an additional 12 % of Gram-negative bacilli. Together, saponin-treated monomicrobial blood cultures allow rapid and reliable identification and AST of Gram-positive and Gram-negative bacteria.

  7. LOG FILE ANALYSIS AND CREATION OF MORE INTELLIGENT WEB SITES

    Directory of Open Access Journals (Sweden)

    Mislav Šimunić

    2012-07-01

    Full Text Available To enable successful performance of any company or business system, both inthe world and in the Republic of Croatia, among many problems relating to its operationsand particularly to maximum utilization and efficiency of the Internet as a media forrunning business (especially in terms of marketing, they should make the best possible useof the present-day global trends and advantages of sophisticated technologies andapproaches to running a business. Bearing in mind the fact of daily increasing competitionand more demanding market, this paper addresses certain scientific and practicalcontribution to continuous analysis of demand market and adaptation thereto by analyzingthe log files and by retroactive effect on the web site. A log file is a carrier of numerousdata and indicators that should be used in the best possible way to improve the entirebusiness operations of a company. However, this is not always simple and easy. The websites differ in size, purpose, and technology used for designing them. For this very reason,the analytic analysis frameworks should be such that can cover any web site and at thesame time leave some space for analyzing and investigating the specific characteristicof each web site and provide for its dynamics by analyzing the log file records. Thoseconsiderations were a basis for this paper

  8. Development of a digital log ratemeter

    Energy Technology Data Exchange (ETDEWEB)

    Domienikan, Claudio; Brito, Andreia; Toledo, Fabio de; Zahn, Guilherme S., E-mail: clanikan@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    A compact log ratemeter that measures and displays an average count rate through a microcomputer is presented. This ratemeter was developed to be used to monitor a laboratory of production of radioactive samples and also for teaching purposes. The main features are log measurement range from .1 to 1.000 counts/sec and adjustable level alarm. The electronic circuit uses a Geiger tube LND7224, and the processed signal is applied to a National Instruments Multifunction I/O USB-6008 connected to a PC through USB input. A program developed in LabView allows storage of data and real-time observation of the rate of radiation evolution. This ratemeter was designed and constructed in the IPEN-CNEN/SP. (author)

  9. INSPIRE and SPIRES Log File Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Adams, Cole; /Wheaton Coll. /SLAC

    2012-08-31

    SPIRES, an aging high-energy physics publication data base, is in the process of being replaced by INSPIRE. In order to ease the transition from SPIRES to INSPIRE it is important to understand user behavior and the drivers for adoption. The goal of this project was to address some questions in regards to the presumed two-thirds of the users still using SPIRES. These questions are answered through analysis of the log files from both websites. A series of scripts were developed to collect and interpret the data contained in the log files. The common search patterns and usage comparisons are made between INSPIRE and SPIRES, and a method for detecting user frustration is presented. The analysis reveals a more even split than originally thought as well as the expected trend of user transition to INSPIRE.

  10. Fidelity susceptibility in the quantum Rabi model

    Science.gov (United States)

    Wei, Bo-Bo; Lv, Xiao-Chen

    2018-01-01

    Quantum criticality usually occurs in many-body systems. Recently it was shown that the quantum Rabi model, which describes a two-level atom coupled to a single model cavity field, presents quantum phase transitions from a normal phase to a superradiate phase when the ratio between the frequency of the two-level atom and the frequency of the cavity field extends to infinity. In this work, we study quantum phase transitions in the quantum Rabi model from the fidelity susceptibility perspective. We found that the fidelity susceptibility and the generalized adiabatic susceptibility present universal finite-size scaling behaviors near the quantum critical point of the Rabi model if the ratio between frequency of the two-level atom and frequency of the cavity field is finite. From the finite-size scaling analysis of the fidelity susceptibility, we found that the adiabatic dimension of the fidelity susceptibility and the generalized adiabatic susceptibility of fourth order in the Rabi model are 4 /3 and 2, respectively. Meanwhile, the correlation length critical exponent and the dynamical critical exponent in the quantum critical point of the Rabi model are found to be 3 /2 and 1 /3 , respectively. Since the fidelity susceptibility and the generalized adiabatic susceptibility are the moments of the quantum noise spectrum which are directly measurable by experiments in linear response regime, the scaling behavior of the fidelity susceptibility in the Rabi model could be tested experimentally. The simple structure of the quantum Rabi model paves the way for experimentally observing the universal scaling behavior of the fidelity susceptibility at a quantum phase transition.

  11. Gerencia logística y global

    Directory of Open Access Journals (Sweden)

    Pablo Cesar Ocampo Vélez

    2009-04-01

    Full Text Available La logística es una filosofía que se encarga de aplicar las buenas pá¡cticas en los macroprocesos, procesos, procedimientos, tareas y productos dentro de una organización, con el fin de satisfacer las necesidades del cliente, quien es la razón de ser de la empresa. Existen entes internacionales que velan porque las compañias en todo el mundo utilicen y difundan las diferentes disciplinas logísticas en toda la red de valor y tengan un mismo enfoque estratégico.El objetivo de este artículo es explicar la existencia de procesos y macroprocesos de clase mundial en la logística, gracias a los cuales hay una gran oportunidad de mejora para los empresarios colombianos, con el fin de reestructurar los procesos estratégicos, tácticos y operacionales de cada Unidad de Negocio, para que sean organizaciones más competitivas, que puedan enfrentar los tratados de libre comercio, brindando mayor sostenibilidad y óptimo nivel de servicio.

  12. Interleukin-1β (IL-1β) & IL-4 gene polymorphisms in patients with systemic lupus erythematosus (SLE) & their association with susceptibility to SLE.

    Science.gov (United States)

    Mohammadoo-Khorasani, Milad; Salimi, Saeedeh; Tabatabai, Ehsan; Sandoughi, Mahnaz; Zakeri, Zahra; Farajian-Mashhadi, Farzaneh

    2016-05-01

    Interleukin-1 (IL-1) is one of the pro-inflammatory cytokines that plays a main role in the regulation of immune and inflammatory responses. Interleukin 4 (IL-4) as an anti-inflammatory cytokine regulates balance between Th1 and Th2 immune responses. this study was undertaken to investigate the IL-1β and IL-4 genes polymorphisms in patients with systemic lupus erythematosus (SLE) and also association between the polymorphisms and susceptibility to SLE. One hundred and sixty three SLE patients and 180 healthy controls were genotyped for the IL-4 VNTR (variable number tandem repeat), IL-1β C-511T and IL-1β T-31C polymorphisms by polymerase chain reaction (PCR) or PCR-RFLP (restriction fragment length polymorphism) method. The frequencies of CC genotype and C allele of the IL-1β T-31C polymorphism were significantly (PSLE patients than controls. Moreover, the frequencies of RP1/RP2 genotype and RP2 allele of IL-4 VNTR polymorphism were significantly (PSLE patients. No association was observed between IL-1β C-511T polymorphism and increased risk of SLE. We observed increased frequency of CT and TT genotypes of IL-1β C-511T polymorphism in SLE patients with malar rash compared to SLE patients without this manifestation. The present findings suggest that IL-1β T-31C and IL-4 VNTR polymorphisms but not IL-1β C-511T polymorphism may contribute in SLE pathogenesis. In addition, CT and TT genotypes of IL-1β C-511T polymorphism were associated with SLE.

  13. Real-Time Optical Antimicrobial Susceptibility Testing

    DEFF Research Database (Denmark)

    Fredborg, Marlene; Andersen, Klaus R; Jørgensen, Erik

    2013-01-01

    Rapid antibiotic susceptibility testing is in highly demand in health-care fields as antimicrobial resistant bacterial strains emerge and spread. Here we describe an optical screening system (oCelloScope), which based on time-lapse imaging of 96 bacteria-antibiotic combinations at a time, introdu......Rapid antibiotic susceptibility testing is in highly demand in health-care fields as antimicrobial resistant bacterial strains emerge and spread. Here we describe an optical screening system (oCelloScope), which based on time-lapse imaging of 96 bacteria-antibiotic combinations at a time......, introduces real-time detection of bacterial growth and antimicrobial susceptibility, with imaging material to support the automatically generated graphs. Automated antibiotic susceptibility tests of a monoculture showed statistically significant antibiotic effect within 6 minutes and within 30 minutes...

  14. Life cycle performances of log wood applied for soil bioengineering constructions

    Science.gov (United States)

    Kalny, Gerda; Strauss-Sieberth, Alexandra; Strauss, Alfred; Rauch, Hans Peter

    2016-04-01

    Nowadays there is a high demand on engineering solutions considering not only technical aspects but also ecological and aesthetic values. Soil bioengineering is a construction technique that uses biological components for hydraulic and civil engineering solutions. Soil bioengineering solutions are based on the application of living plants and other auxiliary materials including among others log wood. This kind of construction material supports the soil bioengineering system as long as the plants as living construction material overtake the stability function. Therefore it is important to know about the durability and the degradation process of the wooden logs to retain the integral performance of a soil bio engineering system. These aspects will be considered within the framework of the interdisciplinary research project „ELWIRA Plants, wood, steel and concrete - life cycle performances as construction materials". Therefore field investigations on soil bioengineering construction material, specifically European Larch wood logs, of different soil bioengineering structures at the river Wien have been conducted. The drilling resistance as a parameter for particular material characteristics of selected logs was measured and analysed. The drilling resistance was measured with a Rinntech Resistograph instrument at different positions of the wooden logs, all surrounded with three different backfills: Fully surrounded with air, with earth contact on one side and near the water surface in wet-dry conditions. The age of the used logs ranges from one year old up to 20 year old. Results show progress of the drilling resistance throughout the whole cross section as an indicator to assess soil bioengineering construction material. Logs surrounded by air showed a higher drilling resistance than logs with earth contact and the ones exposed to wet-dry conditions. Hence the functional capability of wooden logs were analysed and discussed in terms of different levels of degradation

  15. Archimedean-spiral and log-spiral antenna comparison

    Science.gov (United States)

    Lacko, Peter R.; Franck, Charmaine C.; Johnson, Matthew; Ralston, James M.; Bradley, Marshall R.; McCummins, Robert

    2002-08-01

    For several years, ground-penetrating radar (GPR) has been used to search for buried landmines. Most of the evaluation effort on complete detection systems has focused on end-to-end performance metrics (e.g., Pd and Pfa). Here, we focus on the specific performance of one critical component of GPR systems-the antennas. This is the first in a series of papers that will compare the following parameters of many different antennas: (1) the most useful bandwidths, (2) the role of polarization and polarization diversity, (3) spurious coupling effects, and (4) phase-correction considerations. This paper compares four types of Planning Systems, Inc., antennas that were developed for current and past GPR systems. These are a 5.5-in. log-spiral antenna without balun or spiral-arm terminations; 5.75-in. log-spiral antenna with tapered balun and arm termination; 5.5-in. Archimedean-spiral antenna with tapered balun, but without arm terminations; and 5.75-in. Archimedean-spiral antenna with tapered balun and arm terminations. Three main tests were performed to compare the antennas: (1) S11, to show overall matching bandwidth and to reveal discontinuities in the balun-antenna-termination structure; (2) S21, to measure undesired direct-path coupling relative to intended target scattering; and (3) S21, to show direct coupling vs. antenna spacing.

  16. LoG acts as a good feature in the task of image quality assessment

    Science.gov (United States)

    Mou, Xuanqin; Xue, Wufeng; Chen, Congmin; Zhang, Lei

    2014-03-01

    In the previous work, the LoG (Laplacian of Gaussian) signal that is the earliest stage output of human visual neural system was suggested to be useful in image quality assessment (IQA) model design. This work considered that LoG signal carried crucial structural information of IQA in the position of its zero-crossing and proposed a Non-shift Edge (NSE) based IQA model. In this study, we focus on another aspect of the properties of the LoG signal, i.e., LoG whitens the power spectrum of natural images. Here our interest is that: when exposed to unnatural images, specifically distorted images, how does the HVS whitening this type of signals? In this paper, we first investigate the whitening filter for natural image and distorted image respectively, and then suggest that the LoG is also a whitening filter for distorted images to some extent. Based on this fact, we deploy the LOG signal in the task of IQA model design by applying two very simple distance metrics, i.e., the MSE (mean square error) and the correlation. The proposed models are analyzed according to the evaluation performance on three subjective databases. The experimental results validate the usability of the LoG signal in IQA model design and that the proposed models stay in the state-of-the-art IQA models.

  17. Attraction of Tomicus yunnanensis (Coleoptera: Scolytidae to Yunnan Pine Logs with and without Periderm or Phloem: An Effective Monitoring Bait

    Directory of Open Access Journals (Sweden)

    Rong Chun Lu

    2012-01-01

    Full Text Available The Yunnan pine shoot beetle, Tomicus yunnanensis Kirkendall and Faccoli (Coleoptera: Scolytinae is an important pest of Yunnan pine (Pinus yunnanensis Franch in China. Experiments with host log baits were done to develop a pest monitoring system using host tree kairomone. Five Yunnan pine logs (each 10–15 cm diam. × 30-cm long in a trap-log bundle were treated by peeling periderm (outer bark off to expose the phloem, and half of each log was covered with sticky adhesive to capture any attracted adult beetles. Significantly, more beetles were attracted and caught on the periderm-peeled logs (ca 30 beetles/m2 log surface/day than on untreated control logs with adhesive (ca 2.5/m2/day. No significant differences were observed between catches on logs taken from lower or upper halves of Yunnan pines. T. yunnanensis flies mostly during the afternoon according to trap catches throughout the day. Attraction to the periderm-peeled logs decreased considerably when they were peeled further to remove the phloem, indicating phloem volatiles play a role in selection of the host by the beetle. The readily-available log baits appear useful for monitoring pine shoot beetle populations in integrated pest management programs.

  18. Modified Log-LMS adaptive filter with low signal distortion for biomedical applications.

    Science.gov (United States)

    Jiao, Yuzhong; Cheung, Rex Y P; Mok, Mark P C

    2012-01-01

    Life signals from human body, e.g. heartbeat or electrocardiography (ECG), are usually weak and susceptible to external noise and interference. Adaptive filter is a good tool to reduce the influence of ambient noise/interference on the life signals. Least mean squares (LMS) algorithm, as one of most popular adaptive algorithms for active noise cancellation (ANC) by adaptive filtering, has the advantage of easy implementation. In order to further decrease the complexity of LMS algorithm based adaptive filter, a Log-LMS algorithm was proposed, which quantized signals by the function of log2. The algorithm can replace multipliers by simple shifting. However, both LMS algorithm and Log-LMS algorithm have the disadvantage of serious signal distortion in biomedical applications. In this paper, a modified Log-LMS algorithm is presented, which divides the convergence process into two different stages, and utilizes different quantization method in each stage. Two scenarios of biomedical applications are used for analysis, 1) using stethoscope in emergence medical helicopter and 2) measuring ECG under power line interference. The simulated results show that the modified algorithm can achieve fast convergence and low signal distortion in processing periodic life signals.

  19. Narrating illegal logging across the globe

    DEFF Research Database (Denmark)

    Winkel, G.; Leipold, S.; Buhmann, Karin

    2017-01-01

    In the last decade illegal logging has triggered the attention of policy makers and scholars of international forest governance. The issue is multifaceted, involving aspects of social and environmental sustainability, development, trade, access to markets and competitiveness. A vivid academic...... of the world, drawing on the concept of policy narratives. Specifically, we analyse and compare policy narratives in Australia, Cambodia, China, the EU, Indonesia, Peru and the US. Our analysis is grounded on a rich empirical basis consisting of 260 interviews conducted by various researchers, numerous...

  20. Narrating Illegal Logging Across the Globe

    DEFF Research Database (Denmark)

    Winkel, Georg; Leipold, Sina; Buhmann, Karin

    2017-01-01

    In the last decade illegal logging has triggered the attention of policy makers and scholars of international forest governance. The issue is multifaceted, involving aspects of social and environmental sustainability, development, trade, access to markets and competitiveness. A vivid academic...... of the world, drawing on the concept of policy narratives. Specifically, we analyse and compare policy narratives in Australia, Cambodia, China, the EU, Indonesia, Peru and the US. Our analysis is grounded on a rich empirical basis consisting of 260 interviews conducted by various researchers, numerous...

  1. Logística de transporte internacional

    OpenAIRE

    Freitas, Sibele Moraes Miserani de

    2004-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção. O presente trabalho objetiva analisar o processo logístico de transporte disponível, para que os produtos mineiros sejam escoados para o mercado internacional, como instrumento para a melhor distribuição física de mercadorias exportadas através do estudo de caso com a empresa Labtest Diagnostica. Para tanto, são invocadas algumas teorias e posicionamento...

  2. Central nervous system Toll-like receptor expression in response to Theiler's murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains

    Directory of Open Access Journals (Sweden)

    Turrin Nicolas P

    2008-12-01

    Full Text Available Abstract Background In immunopathological diseases, such as multiple sclerosis (MS, genetic and environmental factors that contribute to the initiation and progression of the disease are often discussed. The Theiler murine encephalomyelitis virus-induced demyelination disease (TMEV-IDD model used to study MS reflects this: genetically susceptible mice infected intra-cerebrally with TMEV develop a chronic demyelination disease. TMEV-IDD can be induced in resistant mouse strains by inducing innate immunity with lipopolysaccharide (LPS. Interestingly, Toll-like receptor 4 (TLR4 is the cognate receptor for LPS and its activation can induces up-regulation of other TLRs, such as TLR7 (the receptor for TMEV and 9, known to be involved in autoimmunity. Up-regulation of TLRs could be involved in precipitating an autoimmune susceptible state. Consequently, we looked at TLR expression in the susceptible (SJL/J and resistant (C57BL/6 strains of mice infected with TMEV. The resistant mice were induced to develop TMEV-IDD by two LPS injections following TMEV infection. Results Both strains were found to up-regulate multiple TLRs (TLR2, 7 and 9 following the TMEV infection. Expression of these TLRs and of viral mRNA was significantly greater in infected SJL/J mice. The susceptible SJL/J mice showed up-regulation of TLR3, 6 and 8, which was not seen in C57BL/6 mice. Conclusion Expression of TLRs by susceptible mice and the up-regulation of the TLRs in resistant mice could participate in priming the mice toward an autoimmune state and develop TMEV-IDD. This could have implications on therapies that target TLRs to prevent the emergence of conditions such as MS in patients at risk for the disease.

  3. Geophysical log analysis of selected test and residential wells at the Shenandoah Road National Superfund Site, East Fishkill, Dutchess County, New York

    Science.gov (United States)

    Reynolds, Richard J.; Anderson, J. Alton; Williams, John H.

    2015-01-01

    The U.S. Geological Survey collected and analyzed geophysical logs from 20 test wells and 23 residential wells at the Shenandoah Road National Superfund Site in East Fishkill, New York, from 2006 through 2010 as part of an Interagency Agreement to provide hydrogeologic technical support to the U.S. Environmental Protection Agency, Region 2. The geophysical logs collected include caliper, gamma, acoustic and optical televiewer, deviation, electromagnetic-induction, magnetic-susceptibility, fluid-property, and flow under ambient and pumped conditions. The geophysical logs were analyzed along with single-well aquifer test data and drilling logs to characterize the lithology, fabric, fractures, and flow zones penetrated by the wells. The results of the geophysical log analysis were used as part of the hydrogeologic characterization of the site and in the design of discrete-zone monitoring installations in the test wells and selected residential wells.

  4. Illegal Logging: dari Persoalan Falsafati ke Penegakan Hukum

    OpenAIRE

    hermansyah,

    2009-01-01

    Banyaknya terdakwa dalam kasus illegal logging lebih dikarenakan kekacauan dan carut marutnya sistem penegakan hukum, terutama penegakan hukum dalam bidang kehutanan. Kekacauan bertambah lantaran dalam melihat illegal logging terselit cara pandang yang materialistik dan ekonomi.

  5. Shiitake mushroom production on small diameter oak logs in Ohio

    Science.gov (United States)

    S.M. Bratkovich

    1991-01-01

    Yields of different strains of shiitake mushrooms (Lentinus edodes) were evaluated when produced on small diameter oak logs in Ohio. Logs averaging between 3-4 inches in diameter were inoculated with four spawn strains in 1985.

  6. Differentiation of Primary Central Nervous System Lymphoma and High-Grade Glioma with Dynamic Susceptibility Contrast-Enhanced Perfusion Magnetic Resonance Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Weihua Liao; Yunhai Liu; Xiaoyi Wang; Xinya Jiang; Beisha Tang; Jiasheng Fang; Changqing Chen; Zhongliang Hu (Dept.s of Radiology, Neurology, Neurosurgery, and Pathology, Xiangya Hospital, Central South Univ., Changsha, Hunan (China))

    2009-02-15

    Background: Preoperative differentiation of primary central nervous system lymphomas (PCNSLs) from other tumors is important for presurgical staging, intraoperative management, and postoperative treatment. Dynamic susceptibility contrast-enhanced perfusion magnetic resonance imaging (DSC perfusion MRI) can provide in vivo assessment of the microvasculature in intracranial mass lesions. Purpose: To determine the utility of DSC perfusion MRI in the differentiation of PCNSLs and high-grade gliomas, as well as their pathological and physiological differences. Material and Methods: Nine patients with pathologically proven PCNSLs and 11 patients with high-grade gliomas were examined using a 1.5T MRI scanner. DSC perfusion MRI was performed by gradient-echo echo-planar imaging (GE-EPI). The maximum rCBV ratio, the signal intensity-time curves, and the percentage of signal intensity recovery were obtained. The maximum relative cerebral blood volume (rCBV) ratio and the percentage of signal intensity recovery of PCNSLs were compared with those of high-grade gliomas by using Student's t test. Microvessel density (MVD) was evaluated using immunohistochemical staining of surgical specimens with anti-CD34, and MVDs of the two tumor groups were compared by using Student's t test. Results: The maximum rCBV ratio of primary intracranial lymphomas was 1.72+-0.59, while that of high-grade gliomas was 4.86+-2.18. PCNSLs tended to have relatively low perfusion compared to high-grade gliomas (P=0.001), and the MVD labeled by anti-CD34 of PCNSLs was much lower than that of gliomas (P<0.001). The signal intensity-time curve of primary intracranial lymphomas was different from that of high-grade gliomas. The percentage of signal intensity recovery was significantly greater in PCNSLs compared with that of high-grade gliomas (P<0.001). Conclusion: The difference in DSC perfusion MRI characteristics between PCNSLs and high-grade gliomas is determined by their different

  7. Public PCs: Log Out or Lose Out

    CERN Multimedia

    Computer Security Team

    2013-01-01

    Do you regularly use one of the public Windows or Linux terminals in the CERN library or in front of the Users' Office? Or do you often give presentations or run meetings, workshops or conferences? Did you recently attend a training session in the CERN Training Centre? If you answered at least once with “yes”, we have a plea for you: LOG OUT when done in order to protect your data!   You might recall that CERN considers that “Your Privacy is Paramount”. But this does not come for free. In the few past months, we have received several reports from vigilant people who have spotted open user sessions on public PCs at CERN. Those users simply forgot to log out once their work, training or meeting was over. Their session continued without them being present. Worse, with CERN using a central Single Sign-On (SSO) portal, their login credentials would allow a malicious person at CERN to use those credentials to access that user’s mailbox, DFS ...

  8. The Log-Ratio Beam Position Monitor

    Science.gov (United States)

    Kalinin, A.

    2002-12-01

    Bergoz Instrumentation has designed a new Log-Ratio Beam Position Monitor (LRBPM). It can be used to measure position of a single short bunch, a bunch train, successive and repetitive (circulating) bunches/trains. The monitor has four parallel channels with band pass filters and logarithmic demodulating high dynamic range amplifiers. The amplifiers detect the envelopes of the RF-bursts brought about by the pickup signals in the filters. Log-ratio processing and conversion of the pickup axes to X,Y is done using a broadband analog technique. The monitor can be used either in a continuous mode, or Sample&Hold or Track&Hold modes. In the last two modes, the LRBPM can be triggered by the beam signal itself. The accuracy limits coming from an inherent demodulator noise, logarithmic nonlinearity, speed of response, etc. of the amplifiers (Analog Devices) are discussed. An accessory developed to determine the LRBPM center offset and resolution with the present beam signals is described.

  9. Web application for recording learners’ mouse trajectories and retrieving their study logs for data analysis

    Directory of Open Access Journals (Sweden)

    Yoshinori Miyazaki

    2012-03-01

    Full Text Available With the accelerated implementation of e-learning systems in educational institutions, it has become possible to record learners’ study logs in recent years. It must be admitted that little research has been conducted upon the analysis of the study logs that are obtained. In addition, there is no software that traces the mouse movements of learners during their learning processes, which the authors believe would enable teachers to better understand their students’ behaviors. The objective of this study is to develop a Web application that records students’ study logs, including their mouse trajectories, and to devise an IR tool that can summarize such diversified data. The results of an experiment are also scrutinized to provide an analysis of the relationship between learners’ activities and their study logs.

  10. Genetic susceptibility of periodontitis

    NARCIS (Netherlands)

    Laine, M.L.; Crielaard, W.; Loos, B.G.

    2012-01-01

    In this systematic review, we explore and summarize the peer-reviewed literature on putative genetic risk factors for susceptibility to aggressive and chronic periodontitis. A comprehensive literature search on the PubMed database was performed using the keywords ‘periodontitis’ or ‘periodontal

  11. Fourie susceptible.pmd

    African Journals Online (AJOL)

    Prof. Adipala Ekwamu

    a number of cultivars exhibited field resistance to halo blight and bacterial brown spot, all cultivars were more or less susceptible to .... Cerillos. Alubia. I. 91. 57. Kranskop. Red speckled sugar. II. 97. 63. OPS-RS1. Red speckled sugar. II. 96. 63. OPS-RS2. Red speckled sugar. I. 100. 61. OPS-RS3. Red speckled sugar. II. 97.

  12. Building Bridges with Logs: Collaborative Conversations about Discovery across Library Departments

    Directory of Open Access Journals (Sweden)

    Jimmy Ghaphery

    2016-04-01

    Full Text Available This article describes the use of discovery system search logs as a vehicle for encouraging constructive conversations across departments in an academic library. The project focused on bringing together systems and teaching librarians to evaluate the results of anonymized patron searches in order to improve communication across departments, as well as to identify opportunities for improvement to the discovery system itself.

  13. Development of regional stump-to-mill logging cost estimators

    Science.gov (United States)

    Chris B. LeDoux; John E. Baumgras

    1989-01-01

    Planning logging operations requires estimating the logging costs for the sale or tract being harvested. Decisions need to be made on equipment selection and its application to terrain. In this paper a methodology is described that has been developed and implemented to solve the problem of accurately estimating logging costs by region. The methodology blends field time...

  14. Positive Behavioral Supports: Empirically Supported Use of Behavioral Logs

    Science.gov (United States)

    Krach, S. Kathleen; McCreery, Michael P.; Wilcox, Raven; Focaracci, Shannon D.

    2017-01-01

    Teachers commonly use behavioral logs as a primary method for controlling classroom behavior, but frequently they are using these logs incorrectly. For this reason, this article provides specific information on how to correctly use behavioral logs for techniques such as check-in/check-out, behavioral report cards, and token economies. Each of…

  15. A survey of animal-powered logging in Alabama

    Science.gov (United States)

    Christopher W. Toms; Mark R. Dubois; John C. Bliss; John H. Wilhoit; Robert B. Rummer

    2001-01-01

    In a state with a very large, highly mechanized timber harvesting industry, animal-powered logging still occupies a niche in Alabama as a small-scale harvesting alternative. This article summarizes the results from a study that examined the extent of animal logging in Alabama. We investigated this topic by asking who is logging with animals, where are they working,...

  16. A Loblolly Pine Management Guide: Managing Site Damage from Logging

    Science.gov (United States)

    W.H. McKee; G.E. Hatchell; A.E. Tiarks

    1985-01-01

    Serious damage to forest sites during logging can be avoided through careful planning of logging, preparation of the site for logging, and close supervision of the work.Losses in productivity caused by compaction can be largely restored by cultivation and fertilization.

  17. 10 CFR 39.13 - Specific licenses for well logging.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific licenses for well logging. 39.13 Section 39.13 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR WELL LOGGING Specific Licensing Requirements § 39.13 Specific licenses for well logging. The Commission will approve an...

  18. Veneer-log production and receipts, North Central Region, 1970

    Science.gov (United States)

    Thomas P. Jr. Ginnaty

    1972-01-01

    The 1970 Lake States veneer-log production and mill receipts were 34.4 and 37.0 million board feet, respectively. The Central States produced 23.5 million board feet and received 30.0 million board feet of veneer logs. Veneer-log production and mill receipts dropped substantially throughout the north central region from 1968.

  19. Economic incentives exist to support measures to reduce illegal logging

    Science.gov (United States)

    J.A. Turner; J. Buongiorno; A. Katz; S. Zhu; R. Li

    2008-01-01

    Three studies of the global economic implications of eliminating illegal logging are summarized. Processors of illegally sourced wood would lose from the elimination of illegal logging through high prices for logs and decreased production of wood products. Associated with these changes could be losses in employment and income. Beyond these losses to the processing...

  20. Logging of Rare Rosewood and Palisandre (Dalbergia spp.) within ...

    African Journals Online (AJOL)

    Illegal logging of precious wood has emerged as one of the most severe threats to Madagascar's northeastern rainforests. Thousands of logs, worth millions of dollars, have recently been confiscated at ports of Vohémar, Antalaha, and Toamasina. This report details the logging of rare, endemic rosewood and palisandre ...

  1. Petroleum Potentials and Well Log Evaluation from Niger Delta Basin

    African Journals Online (AJOL)

    It has being shown that the Niger Delta Basin has spectacularly maintained a thick sedimentary apron and certain petroleum geological features favourable for petroleum generation. This study reports the petroleum potential and well log evaluation of logs in three wells to characterize the reservoir sand bodies. The well log ...

  2. Examples and counter-examples of log-symplectic manifolds

    NARCIS (Netherlands)

    Cavalcanti, Gil R.

    We study topological properties of log-symplectic structures and produce examples of compact manifolds with such structures. Notably, we show that several symplectic manifolds do not admit bona fide log-symplectic structures and several bona fide log-symplectic manifolds do not admit symplectic

  3. Displacement length and velocity of tagged logs in the tagliamento river

    Directory of Open Access Journals (Sweden)

    Diego Ravazzolo

    2013-09-01

    Full Text Available Large wood enhance the dynamics of geomorphic processes in river systems, increases the morphological complexity of the channel bed, and provides habitats for fish and invertebrates. On the other side, if transported during high-magnitude events, large wood pieces can increase flood risks in sensitive places such as bridges and narrow cross sections prone to outbank flows. However, the dynamics and mobility of logs in rivers is poorly understood, especially in wide gravel-bed rivers. Recent studies have employed fixed video cameras to assess logs velocity, but little evidence is still available about travel length during flood events of different magnitude. This study was conducted in a valley reach of the Tagliamento river, located in the North East of Italy. The Tagliamento river is approximately 800 m wide in the study area, and is characterized by relatively high natural conditions and complex fluvial dynamics. Log mobility have been studied from June 2010 to October 2011, a period characterized by a relatively high magnitude flood in November 2010. Log mobility and displacement during floods have been measured by implanting active radio transmitters (RFID in 113 logs and GPS track devices in 42 logs. The first devices allow to recover the log after flood events by using a portable antenna, and to derive the displacement length over the monitoring period, whereas the second devices allows to calculate instantaneous (1 sec and average log velocity of moving logs. Recovery rate of logs equipped with RFID and GPS was about 50% and 60%, respectively. A preliminary analysis of the data collected indicates that there is a positive relationship between displacement length and the peak of flood events, as well as a positive relationship between log velocity and the flood magnitude. Also, a critical flow rate over which logs stranded on active bars can be transported has been identified. The ability to predict wood mobility in gravel-bed rivers could

  4. An interactive machine-learning approach for defect detection in computed tomogaraphy (CT) images of hardwood logs

    Science.gov (United States)

    Erol Sarigul; A. Lynn Abbott; Daniel L. Schmoldt; Philip A. Araman

    2005-01-01

    This paper describes recent progress in the analysis of computed tomography (CT) images of hardwood logs. The long-term goal of the work is to develop a system that is capable of autonomous (or semiautonomous) detection of internal defects, so that log breakdown decisions can be optimized based on defect locations. The problem is difficult because wood exhibits large...

  5. Comparative trends in log populations in northern Arizona mixed-conifer and ponderosa pine forests following severe drought

    Science.gov (United States)

    Joseph L. Ganey; Scott C. Vojta

    2017-01-01

    Logs provide an important form of coarse woody debris in forest systems, contributing to numerous ecological processes and affecting wildlife habitat and fuel complexes. Despite this, little information is available on the dynamics of log populations in southwestern ponderosa pine (Pinus ponderosa) and especially mixed-conifer forests. A recent episode of elevated tree...

  6. Testing compression strength of wood logs by drilling resistance

    Science.gov (United States)

    Kalny, Gerda; Rados, Kristijan; Rauch, Hans Peter

    2017-04-01

    Soil bioengineering is a construction technique using biological components for hydraulic and civil engineering solutions, based on the application of living plants and other auxiliary materials including among others log wood. Considering the reliability of the construction it is important to know about the durability and the degradation process of the wooden logs to estimate and retain the integral performance of a soil bioengineering system. An important performance indicator is the compression strength, but this parameter is not easy to examine by non-destructive methods. The Rinntech Resistograph is an instrument to measure the drilling resistance by a 3 mm wide needle in a wooden log. It is a quasi-non-destructive method as the remaining hole has no weakening effects to the wood. This is an easy procedure but result in values, hard to interpret. To assign drilling resistance values to specific compression strengths, wooden specimens were tested in an experiment and analysed with the Resistograph. Afterwards compression tests were done at the same specimens. This should allow an easier interpretation of drilling resistance curves in future. For detailed analyses specimens were investigated by means of branch inclusions, cracks and distances between annual rings. Wood specimens are tested perpendicular to the grain. First results show a correlation between drilling resistance and compression strength by using the mean drilling resistance, average width of the annual rings and the mean range of the minima and maxima values as factors for the drilling resistance. The extended limit of proportionality, the offset yield strength and the maximum strength were taken as parameters for compression strength. Further investigations at a second point in time strengthen these results.

  7. The association forecasting of 13 variants within seven asthma susceptibility genes on 3 serum IgE groups in Taiwanese population by integrating of adaptive neuro-fuzzy inference system (ANFIS) and classification analysis methods.

    Science.gov (United States)

    Wang, Cheng-Hang; Liu, Baw-Jhiune; Wu, Lawrence Shih-Hsin

    2012-02-01

    Asthma is one of the most common chronic diseases in children. It is caused by complicated coactions between various genetic factors and environmental allergens. The study aims to integrate the concept of implementing adaptive neuro-fuzzy inference system (ANFIS) and classification analysis methods for forecasting the association of asthma susceptibility genes on 3 serum IgE groups. The ANFIS model was trained and tested with data sets obtained from 425 asthmatic subjects and 483 non-asthma subjects from the Taiwanese population. We assessed 13 single-nucleotide polymorphisms (SNPs) in seven well-known asthma susceptibility genes; firstly, the proposed ANFIS model learned to reduce input features from the 13 SNPs. And secondly, the classification will be used to classify the serum IgE groups from the simulated SNPs results. The performance of the ANFIS model, classification accuracies and the results confirmed that the integration of ANFIS and classified analysis has potential in association discovery.

  8. Use of historical logging patterns to identify disproportionately logged ecosystems within temperate rainforests of southeastern Alaska.

    Science.gov (United States)

    Albert, David M; Schoen, John W

    2013-08-01

    The forests of southeastern Alaska remain largely intact and contain a substantial proportion of Earth's remaining old-growth temperate rainforest. Nonetheless, industrial-scale logging has occurred since the 1950s within a relatively narrow range of forest types that has never been quantified at a regional scale. We analyzed historical patterns of logging from 1954 through 2004 and compared the relative rates of change among forest types, landform associations, and biogeographic provinces. We found a consistent pattern of disproportionate logging at multiple scales, including large-tree stands and landscapes with contiguous productive old-growth forests. The highest rates of change were among landform associations and biogeographic provinces that originally contained the largest concentrations of productive old growth (i.e., timber volume >46.6 m³/ha). Although only 11.9% of productive old-growth forests have been logged region wide, large-tree stands have been reduced by at least 28.1%, karst forests by 37%, and landscapes with the highest volume of contiguous old growth by 66.5%. Within some island biogeographic provinces, loss of rare forest types may place local viability of species dependent on old growth at risk of extirpation. Examination of historical patterns of change among ecological forest types can facilitate planning for conservation of biodiversity and sustainable use of forest resources. © 2013 Society for Conservation Biology.

  9. Rill erosion in burned and salvage logged western montane forests: Effects of logging equipment type, traffic level, and slash treatment

    Science.gov (United States)

    J. W. Wagenbrenner; P. R. Robichaud; R. E. Brown

    2016-01-01

    Following wildfires, forest managers often consider salvage logging burned trees to recover monetary value of timber, reduce fuel loads, or to meet other objectives. Relatively little is known about the cumulative hydrologic effects of wildfire and subsequent timber harvest using logging equipment. We used controlled rill experiments in logged and unlogged (control)...

  10. Does selective logging change ground-dwelling beetle assemblages in a subtropical broad-leafed forest of China?

    Science.gov (United States)

    Yu, Xiao-Dong; Liu, Chong-Ling; Lü, Liang; Bearer, Scott L; Luo, Tian-Hong; Zhou, Hong-Zhang

    2017-04-01

    Selective logging with natural regeneration is advocated as a near-to-nature strategy and has been implemented in many forested systems during the last decades. However, the efficiency of such practices for the maintenance of forest species are poorly understood. We compared the species richness, abundance and composition of ground-dwelling beetles between selectively logged and unlogged forests to evaluate the possible effects of selective logging in a subtropical broad-leafed forest in southeastern China. Using pitfall traps, beetles were sampled in two naturally regenerating stands after clearcuts (ca. 50 years old, stem-exclusion stage: selectively logged 20 years ago) and two mature stands (> 80 years old, understory re-initiation stage: selectively logged 50 years ago) during 2009 and 2010. Overall, selective logging had no significant effects on total beetle richness and abundance, but saproxylic species group and some abundant forest species significantly decreased in abundance in selectively logged plots compared with unlogged plots in mature stands. Beetle assemblages showed significant differences between selectively logged and unlogged plots in mature stands. Some environmental characteristics associated with selective logging (e.g., logging strategy, stand age, and cover of shrub and moss layers) were the most important variables explaining beetle assemblage structure. Our results conclude that selective logging has no significant impacts on overall richness and abundance of ground-dwelling beetles. However, the negative effects of selective logging on saproxylic species group and some unlogged forest specialists highlight the need for large intact forested areas for sustaining the existence of forest specialist beetles. © 2015 Institute of Zoology, Chinese Academy of Sciences.

  11. Simulation Control Graphical User Interface Logging Report

    Science.gov (United States)

    Hewling, Karl B., Jr.

    2012-01-01

    One of the many tasks of my project was to revise the code of the Simulation Control Graphical User Interface (SIM GUI) to enable logging functionality to a file. I was also tasked with developing a script that directed the startup and initialization flow of the various LCS software components. This makes sure that a software component will not spin up until all the appropriate dependencies have been configured properly. Also I was able to assist hardware modelers in verifying the configuration of models after they have been upgraded to a new software version. I developed some code that analyzes the MDL files to determine if any error were generated due to the upgrade process. Another one of the projects assigned to me was supporting the End-to-End Hardware/Software Daily Tag-up meeting.

  12. Regularized Multitask Learning for Multidimensional Log-Density Gradient Estimation.

    Science.gov (United States)

    Yamane, Ikko; Sasaki, Hiroaki; Sugiyama, Masashi

    2016-07-01

    Log-density gradient estimation is a fundamental statistical problem and possesses various practical applications such as clustering and measuring nongaussianity. A naive two-step approach of first estimating the density and then taking its log gradient is unreliable because an accurate density estimate does not necessarily lead to an accurate log-density gradient estimate. To cope with this problem, a method to directly estimate the log-density gradient without density estimation has been explored and demonstrated to work much better than the two-step method. The objective of this letter is to improve the performance of this direct method in multidimensional cases. Our idea is to regard the problem of log-density gradient estimation in each dimension as a task and apply regularized multitask learning to the direct log-density gradient estimator. We experimentally demonstrate the usefulness of the proposed multitask method in log-density gradient estimation and mode-seeking clustering.

  13. Genetic Susceptibility to Atherosclerosis

    Directory of Open Access Journals (Sweden)

    Sanja Kovacic

    2012-01-01

    Full Text Available Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic ground significantly influences susceptibility to atherosclerotic vascular diseases. Besides further investigations of monogenetic diseases, candidate genes, genetic polymorphisms, and susceptibility loci associated with atherosclerotic diseases have been identified in recent years, and their number is rapidly increasing. This paper discusses main genetic investigations fields associated with human atherosclerotic vascular diseases. The paper concludes with a discussion of the directions and implications of future genetic research in arteriosclerosis with an emphasis on prospective prediction from an early age of individuals who are predisposed to develop premature atherosclerosis as well as to facilitate the discovery of novel drug targets.

  14. An acousto-electric effect logging detector in boreholes

    Science.gov (United States)

    Lu, Junqiang; Ju, Xiaodong; Men, Baiyong; Zhao, Honglin; Qiao, Wenxiao; Duan, Wenxing

    2017-03-01

    An acousto-electric effect logging detector in boreholes is introduced. The detector can measure the first and second type of acousto-electric effect in the downhole. The acoustic transducer of the detector is composed of a transmitting transducer T and a receiving transducer array R1, R2, and R3, and the electrode is composed of power supply electrodes A and B, and measuring electrodes E1, E2, E3, and E4. The minimum spacing between the transmitter transducer T and the receiving transducer R1 is 2500 mm, and the spacing between the receiving transducer is 300 mm. The spacing of the power supply electrode is 1500 mm, and the spacing of the measuring electrode is 300 mm. The detector circuits include the acoustic transducer excitation circuit, power supply electrode excitation circuit, acoustic signal-processing and acquisition circuit, electrical signal-processing and acquisition circuit, system main control circuit, and telemetry interface circuit. Laboratory and field tests were conducted. The sound pressure of the acoustic transmitting transducer at 1 m is up to 70 kPa. The typical acousto-electric logging signal has been observed from the field test in the downhole formation.

  15. Effects of stream-adjacent logging in fishless headwaters on downstream coastal cutthroat trout

    Science.gov (United States)

    Bateman, Douglas S.; Sloat, Matthew R.; Gresswell, Robert E.; Berger, Aaron M.; Hockman-Wert, David; Leer, David W.; Skaugset, Arne E.

    2016-01-01

    To investigate effects of headwater logging on downstream coastal cutthroat trout (Oncorhynchus clarkii clarkii) populations, we monitored stream habitat and biotic indicators including biomass, abundance, growth, movement, and survival over 8 years using a paired-watershed approach. Reference and logged catchments were located on private industrial forestland on ∼60-year harvest rotation. Five clearcuts (14% of the logged catchment area) were adjacent to fishless portions of the headwater streams, and contemporary regulations did not require riparian forest buffers in the treatment catchment. Logging did not have significant negative effects on downstream coastal cutthroat trout populations for the duration of the sample period. Indeed, the only statistically significant response of fish populations following logging in fishless headwaters was an increase in late-summer biomass (g·m−2) of age-1+ coastal cutthroat trout in tributaries. Ultimately, the ability to make broad generalizations concerning effects of timber harvest is difficult because response to disturbance (anthropogenically influenced or not) in aquatic systems is complex and context-dependent, but our findings provide one example of environmentally compatible commercial logging in a regenerated forest setting.

  16. Self-similar log-periodic structures in western stock markets from 2000

    Energy Technology Data Exchange (ETDEWEB)

    M. Bartolozzi; S. Drozdz; D. B. Leinweber; J. Speth; A. W. Thomas

    2005-09-01

    The presence of log-periodic structures before and after stock market crashes is considered to be an imprint of an intrinsic discrete scale invariance (DSI) in this complex system. The fractal framework of the theory leaves open the possibility of observing self-similar log-periodic structures at different time scales. In the present work, we analyze the daily closures of four of the most important indices worldwide since 2000: the DAX for Germany and the NASDAQ-100, the S&P 500 and the Dow Jones for the United States. The qualitative behavior of these different markets is similar during the temporal frame studied. Evidence is found for decelerating log-periodic oscillations of duration about two years and starting in September 2000. Moreover, a nested sub-structure starting in May 2002 is revealed, bringing more evidence to support the hypothesis of self-similar, log-periodic behavior. Ongoing log-periodic oscillations are also revealed. A Lomb analysis over the aforementioned periods indicates a preferential scaling factor lambda~2. Higher order harmonics are also present. The spectral pattern of the data has been found to be similar to that of a Weierstrass-type function, used as a prototype of a log-periodic fractal function.

  17. Self-Similar Log-Periodic Structures in Western STOCK Markets from 2000

    Science.gov (United States)

    Bartolozzi, M.; Drożdż, S.; Leinweber, D. B.; Speth, J.; Thomas, A. W.

    The presence of log-periodic structures before and after stock market crashes is considered to be an imprint of an intrinsic discrete scale invariance (DSI) in this complex system. The fractal framework of the theory leaves open the possibility of observing self-similar log-periodic structures at different time scales. In the present work, we analyze the daily closures of four of the most important indices worldwide since 2000: the DAX for Germany and the NASDAQ-100, the S&P 500 and the Dow Jones for the United States. The qualitative behavior of these different markets is similar during the temporal frame studied. Evidence is found for decelerating log-periodic oscillations of duration about two years and starting in September 2000. Moreover, a nested sub-structure starting in May 2002 is revealed, bringing more evidence to support the hypothesis of self-similar, log-periodic behavior. Ongoing log-periodic oscillations are also revealed. A Lomb analysis over the aforementioned periods indicates a preferential scaling factor λ~2. Higher order harmonics are also present. The spectral pattern of the data has been found to be similar to that of a Weierstrass-type function, used as a prototype of a log-periodic fractal function.

  18. Coal log pipeline research at the University of Missouri. [Quarterly report No. 6, November 26, 1991--February 25, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Liu, H.

    1992-03-01

    Project tasks: Perform the necessary testing and development to demonstrate that the amount of binder in coal logs can be reduced to 8% or lower to produce logs with adequate strength to eliminate breakage during pipeline transportation, under conditions experienced in long distance pipeline systems. Prior to conducting any testing and demonstration, grantee shall perform an information search and make full determination of all previous attempts to extrude or briquette coal, upon which the testing and demonstration shall be based. Perform the necessary development to demonstrate a small model of the most promising injection system for coal-logs, and test the logs produced from Task 1. Conduct economic analysis of coal-log pipeline, based upon the work to date. Refine and complete the economic model. Prepare a final report for DOE.

  19. Marijuana Usage and Hypnotic Susceptibility

    Science.gov (United States)

    Franzini, Louis R.; McDonald, Roy D.

    1973-01-01

    Anonymous self-reported drug usage data and hypnotic susceptibility scores were obtained from 282 college students. Frequent marijuana users (more than 10 times) showed greater susceptibility to hypnosis than nonusers. (Author)

  20. Realisation of a system for interactive borehole logging data evaluation in the exploration of mineral resources (coal); Aufbau eines interaktiven Auswertesystems fuer Bohrlochmessungen in Explorationsbohrungen auf mineralische Rohstoffe (Kohle)

    Energy Technology Data Exchange (ETDEWEB)

    Ruebel, H.J.

    1998-08-01

    The project was intended to establish an integrated system for processing and evaluation of measured well data. With the ``Well Data System`` and its specially developed programs and interfaces to existing software, special evaluation programs can be run at any time. The system includes all peripheral devices, from data acquisition to data storage through to the plotting device. The report explains the performance of the system using as an example a very comprehensive examination of the capabilities to correct density data obtained in a coal desposit. (orig./CB) [Deutsch] Ziel des Projekts war die Schaffung eines integrierten Systems zur Bearbeitung von Bohrlochmessungen. Mit dem ``Well Data System`` und den neu entwickelten Programmen innerhalb des WDS sowie den Schnittstellen zu vorhandener Software koennen jederzeit spezielle Auswertungen durchgefuehrt werden. Die gesamte Peripherie, angefangen von der Datenerfassung ueber die Datenspeicherung bis hin zur Ausgabe (Plot) ist vorhanden. Im folgenden wird die Arbeitsweise des Systems mittels einer umfangreichen Untersuchung ueber die Korrekturmoeglichkeiten von Dichtemessungen fuer Kohle gezeigt. (orig./MSK)

  1. The electricity sector susceptibility of European countries to climate change

    Science.gov (United States)

    Klein, Daniel R.; Olonscheck, Mady; Walther, Carsten; Kropp, Jürgen P.

    2014-05-01

    Due to the close relationship between electricity consumption, production and temperature, the electricity systems of countries are particularly susceptible to climate change. Based on a number of quantitative influencing factors, we provide a relative index for 21 European countries. This allows relevant stakeholders to identify the main influencing factors that determine the electricity system susceptibility of their country. The index was determined using 14 influencing factors that include those that increase or decrease susceptibility. This includes information on monthly mean temperature, electricity consumption, import, export and production by energy source for the period 2000-2011. Moreover, we consider the results of nine global climate models regarding future temperature changes as well as data on air conditioner prevalence by country. A quantitative relative ranked index describing the susceptibility of each country's electricity system is provided. In both Luxembourg and Greece, which top the list, the inability to meet electricity demand with inland production as well as a heavy reliance on combustible fuel electricity production explain part of the high relative susceptibility. Summer electricity consumption (another influencing factor) is expected to increase in Greece where current relatively warm temperatures, in the context of the countries included in this study, are expected to increase in the future. Comparatively, Norway was the least susceptible country based on our index. Norway is expected to benefit from rising projected temperatures, which will decrease winter electricity consumption and limit susceptibility. Furthermore, Norway's current electricity production exceeds consumption demand and is largely based on hydro, which also decreases susceptibility. The findings of this study enable policy makers, scientists and energy managers to examine the most important influencing factors that increase susceptibility and focus their adaptation

  2. Detection of amphotericin B resistance in Candida haemulonii and closely related species by use of the Etest, Vitek-2 yeast susceptibility system, and CLSI and EUCAST broth microdilution methods.

    Science.gov (United States)

    Shin, Jong Hee; Kim, Mi-Na; Jang, Sook Jin; Ju, Min Young; Kim, Soo Hyun; Shin, Myung Geun; Suh, Soon Pal; Ryang, Dong Wook

    2012-06-01

    The emerging fungal pathogens Candida haemulonii and Candida pseudohaemulonii often show high-level resistance to amphotericin B (AMB). We compared the utilities of five antifungal susceptibility testing methods, i.e., the Etest using Mueller-Hinton agar supplemented with glucose and methylene blue (Etest-MH), the Etest using RPMI agar supplemented with glucose (Etest-RPG), the Vitek-2 yeast susceptibility system, and the Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) broth microdilution methods, for the detection of AMB-resistant isolates of C. haemulonii and closely related species. Thirty-eight clinical isolates (8 C. haemulonii, 10 C. pseudohaemulonii, and 20 Candida auris isolates) were analyzed. Of the 18 C. haemulonii and C. pseudohaemulonii isolates, 18, 15, 18, 10, and 9 exhibited AMB MICs of >1 μg/ml by the Etest-MH, Etest-RPG, Vitek-2, CLSI, and EUCAST methods, respectively. All 20 C. auris isolates showed AMB MICs of ≤1 μg/ml by all five methods. Of the methods, the Etest-MH generated the broadest distribution of AMB MICs for all 38 isolates and showed the best discrimination between the C. haemulonii and C. pseudohaemulonii isolates (4 to 32 μg/ml) and those of C. auris (0.125 to 0.5 μg/ml). Taking the Etest-MH as the reference method, the essential agreements (within two dilutions) for the Etest-RPG, Vitek-2, CLSI, and EUCAST methods were 84, 92, 55, and 55%, respectively; the categorical agreements were 92, 92, 79, and 76%, respectively. This study provides the first data on the efficacy of the Etest-MH and its excellent agreement with Vitek-2 for discriminating AMB-resistant from AMB-susceptible isolates of these Candida species.

  3. From Log Files to Assessment Metrics: Measuring Students' Science Inquiry Skills Using Educational Data Mining

    Science.gov (United States)

    Gobert, Janice D.; Sao Pedro, Michael; Raziuddin, Juelaila; Baker, Ryan S.

    2013-01-01

    We present a method for assessing science inquiry performance, specifically for the inquiry skill of designing and conducting experiments, using educational data mining on students' log data from online microworlds in the Inq-ITS system (Inquiry Intelligent Tutoring System; www.inq-its.org). In our approach, we use a 2-step process: First we use…

  4. The order parameter and susceptibility of the 3D Ising-like system in an external field near the phase transition point

    Directory of Open Access Journals (Sweden)

    M.P. Kozlovskii

    2010-01-01

    Full Text Available The present work is devoted to the investigation of the 3D Ising-like model in the presence of an external field in the vicinity of critical point. The method of collective variables is used. General expressions for the order parameter and susceptibility are calculated as functions of temperature and the external field as well as scaling functions of that are explicitly obtained. The results are compared with the ones obtained within the framework of parametric representation of the equation of state and Monte Carlo simulations. New expression for the exit point from critical regime of the order parameter fluctuations is proposed and used for the calculation.

  5. Thresholds of logging intensity to maintain tropical forest biodiversity.

    Science.gov (United States)

    Burivalova, Zuzana; Sekercioğlu, Cağan Hakkı; Koh, Lian Pin

    2014-08-18

    Primary tropical forests are lost at an alarming rate, and much of the remaining forest is being degraded by selective logging. Yet, the impacts of logging on biodiversity remain poorly understood, in part due to the seemingly conflicting findings of case studies: about as many studies have reported increases in biodiversity after selective logging as have reported decreases. Consequently, meta-analytical studies that treat selective logging as a uniform land use tend to conclude that logging has negligible effects on biodiversity. However, selectively logged forests might not all be the same. Through a pantropical meta-analysis and using an information-theoretic approach, we compared and tested alternative hypotheses for key predictors of the richness of tropical forest fauna in logged forest. We found that the species richness of invertebrates, amphibians, and mammals decreases as logging intensity increases and that this effect varies with taxonomic group and continental location. In particular, mammals and amphibians would suffer a halving of species richness at logging intensities of 38 m(3) ha(-1) and 63 m(3) ha(-1), respectively. Birds exhibit an opposing trend as their total species richness increases with logging intensity. An analysis of forest bird species, however, suggests that this pattern is largely due to an influx of habitat generalists into heavily logged areas while forest specialist species decline. Our study provides a quantitative analysis of the nuanced responses of species along a gradient of logging intensity, which could help inform evidence-based sustainable logging practices from the perspective of biodiversity conservation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Nut Production in Bertholletia excelsa across a Logged Forest Mosaic: Implications for Multiple Forest Use.

    Directory of Open Access Journals (Sweden)

    Cara A Rockwell

    Full Text Available Although many examples of multiple-use forest management may be found in tropical smallholder systems, few studies provide empirical support for the integration of selective timber harvesting with non-timber forest product (NTFP extraction. Brazil nut (Bertholletia excelsa, Lecythidaceae is one of the world's most economically-important NTFP species extracted almost entirely from natural forests across the Amazon Basin. An obligate out-crosser, Brazil nut flowers are pollinated by large-bodied bees, a process resulting in a hard round fruit that takes up to 14 months to mature. As many smallholders turn to the financial security provided by timber, Brazil nut fruits are increasingly being harvested in logged forests. We tested the influence of tree and stand-level covariates (distance to nearest cut stump and local logging intensity on total nut production at the individual tree level in five recently logged Brazil nut concessions covering about 4000 ha of forest in Madre de Dios, Peru. Our field team accompanied Brazil nut harvesters during the traditional harvest period (January-April 2012 and January-April 2013 in order to collect data on fruit production. Three hundred and ninety-nine (approximately 80% of the 499 trees included in this study were at least 100 m from the nearest cut stump, suggesting that concessionaires avoid logging near adult Brazil nut trees. Yet even for those trees on the edge of logging gaps, distance to nearest cut stump and local logging intensity did not have a statistically significant influence on Brazil nut production at the applied logging intensities (typically 1-2 timber trees removed per ha. In one concession where at least 4 trees ha-1 were removed, however, the logging intensity covariate resulted in a marginally significant (0.09 P value, highlighting a potential risk for a drop in nut production at higher intensities. While we do not suggest that logging activities should be completely avoided in Brazil

  7. Nut Production in Bertholletia excelsa across a Logged Forest Mosaic: Implications for Multiple Forest Use.

    Science.gov (United States)

    Rockwell, Cara A; Guariguata, Manuel R; Menton, Mary; Arroyo Quispe, Eriks; Quaedvlieg, Julia; Warren-Thomas, Eleanor; Fernandez Silva, Harol; Jurado Rojas, Edwin Eduardo; Kohagura Arrunátegui, José Andrés Hideki; Meza Vega, Luis Alberto; Revilla Vera, Olivia; Quenta Hancco, Roger; Valera Tito, Jonatan Frank; Villarroel Panduro, Betxy Tabita; Yucra Salas, Juan José

    2015-01-01

    Although many examples of multiple-use forest management may be found in tropical smallholder systems, few studies provide empirical support for the integration of selective timber harvesting with non-timber forest product (NTFP) extraction. Brazil nut (Bertholletia excelsa, Lecythidaceae) is one of the world's most economically-important NTFP species extracted almost entirely from natural forests across the Amazon Basin. An obligate out-crosser, Brazil nut flowers are pollinated by large-bodied bees, a process resulting in a hard round fruit that takes up to 14 months to mature. As many smallholders turn to the financial security provided by timber, Brazil nut fruits are increasingly being harvested in logged forests. We tested the influence of tree and stand-level covariates (distance to nearest cut stump and local logging intensity) on total nut production at the individual tree level in five recently logged Brazil nut concessions covering about 4000 ha of forest in Madre de Dios, Peru. Our field team accompanied Brazil nut harvesters during the traditional harvest period (January-April 2012 and January-April 2013) in order to collect data on fruit production. Three hundred and ninety-nine (approximately 80%) of the 499 trees included in this study were at least 100 m from the nearest cut stump, suggesting that concessionaires avoid logging near adult Brazil nut trees. Yet even for those trees on the edge of logging gaps, distance to nearest cut stump and local logging intensity did not have a statistically significant influence on Brazil nut production at the applied logging intensities (typically 1-2 timber trees removed per ha). In one concession where at least 4 trees ha-1 were removed, however, the logging intensity covariate resulted in a marginally significant (0.09) P value, highlighting a potential risk for a drop in nut production at higher intensities. While we do not suggest that logging activities should be completely avoided in Brazil nut rich

  8. Nut Production in Bertholletia excelsa across a Logged Forest Mosaic: Implications for Multiple Forest Use

    Science.gov (United States)

    Rockwell, Cara A.; Guariguata, Manuel R.; Menton, Mary; Arroyo Quispe, Eriks; Quaedvlieg, Julia; Warren-Thomas, Eleanor; Fernandez Silva, Harol; Jurado Rojas, Edwin Eduardo; Kohagura Arrunátegui, José Andrés Hideki; Meza Vega, Luis Alberto; Revilla Vera, Olivia; Valera Tito, Jonatan Frank; Villarroel Panduro, Betxy Tabita; Yucra Salas, Juan José

    2015-01-01

    Although many examples of multiple-use forest management may be found in tropical smallholder systems, few studies provide empirical support for the integration of selective timber harvesting with non-timber forest product (NTFP) extraction. Brazil nut (Bertholletia excelsa, Lecythidaceae) is one of the world’s most economically-important NTFP species extracted almost entirely from natural forests across the Amazon Basin. An obligate out-crosser, Brazil nut flowers are pollinated by large-bodied bees, a process resulting in a hard round fruit that takes up to 14 months to mature. As many smallholders turn to the financial security provided by timber, Brazil nut fruits are increasingly being harvested in logged forests. We tested the influence of tree and stand-level covariates (distance to nearest cut stump and local logging intensity) on total nut production at the individual tree level in five recently logged Brazil nut concessions covering about 4000 ha of forest in Madre de Dios, Peru. Our field team accompanied Brazil nut harvesters during the traditional harvest period (January-April 2012 and January-April 2013) in order to collect data on fruit production. Three hundred and ninety-nine (approximately 80%) of the 499 trees included in this study were at least 100 m from the nearest cut stump, suggesting that concessionaires avoid logging near adult Brazil nut trees. Yet even for those trees on the edge of logging gaps, distance to nearest cut stump and local logging intensity did not have a statistically significant influence on Brazil nut production at the applied logging intensities (typically 1–2 timber trees removed per ha). In one concession where at least 4 trees ha-1 were removed, however, the logging intensity covariate resulted in a marginally significant (0.09) P value, highlighting a potential risk for a drop in nut production at higher intensities. While we do not suggest that logging activities should be completely avoided in Brazil nut rich

  9. Reducing the risk of cyber threats in utilities through log management

    Energy Technology Data Exchange (ETDEWEB)

    Patnaik, A. [ArcSight, Cupertino, CA (United States)

    2010-01-15

    Electrical blackouts caused by terrorists hacking into targeted control systems have already occurred in Brazil. A patchwork of security tools is needed to reduce potential threats. The continuous collection and analysis of data is also needed to detect cyber threats. The real time correlation of logs across all systems, applications and users is needed to ensure the reliability and security of the power grid. Solutions must also integrate well with identity management sources in order to prevent remote access account hijacking. Effective log management can be used to detect threats and reduce the risk of power outages. 1 fig.

  10. Gulf of Mexico Gas Hydrate Joint Industry Project Leg II logging-while-drilling data acquisition and anaylsis

    Science.gov (United States)

    Collett, Timothy S.; Lee, Myung W.; Zyrianova, Margarita V.; Mrozewski, Stefan A.; Guerin, Gilles; Cook, Ann E.; Goldberg, Dave S.

    2012-01-01

    One of the objectives of the Gulf of MexicoGasHydrateJointIndustryProjectLegII (GOM JIP LegII) was the collection of a comprehensive suite of logging-while-drilling (LWD) data within gas-hydrate-bearing sand reservoirs in order to make accurate estimates of the concentration of gashydrates under various geologic conditions and to understand the geologic controls on the occurrence of gashydrate at each of the sites drilled during this expedition. The LWD sensors just above the drill bit provided important information on the nature of the sediments and the occurrence of gashydrate. There has been significant advancements in the use of downhole well-logging tools to acquire detailed information on the occurrence of gashydrate in nature: From using electrical resistivity and acoustic logs to identify gashydrate occurrences in wells to where wireline and advanced logging-while-drilling tools are routinely used to examine the petrophysical nature of gashydrate reservoirs and the distribution and concentration of gashydrates within various complex reservoir systems. Recent integrated sediment coring and well-log studies have confirmed that electrical resistivity and acoustic velocity data can yield accurate gashydrate saturations in sediment grain supported (isotropic) systems such as sand reservoirs, but more advanced log analysis models are required to characterize gashydrate in fractured (anisotropic) reservoir systems. In support of the GOM JIP LegII effort, well-log data montages have been compiled and presented in this report which includes downhole logs obtained from all seven wells drilled during this expedition with a focus on identifying and characterizing the potential gas-hydrate-bearing sedimentary section in each of the wells. Also presented and reviewed in this report are the gas-hydrate saturation and sediment porosity logs for each of the wells as calculated from available downhole well logs.

  11. Gulf of Mexico Gas Hydrate Joint Industry Project Leg II logging-while-drilling data acquisition and analysis

    Science.gov (United States)

    Collett, Timothy S.; Lee, Wyung W.; Zyrianova, Margarita V.; Mrozewski, Stefan A.; Guerin, Gilles; Cook, Ann E.; Goldberg, Dave S.

    2012-01-01

    One of the objectives of the Gulf of Mexico Gas Hydrate Joint Industry Project Leg II (GOM JIP Leg II) was the collection of a comprehensive suite of logging-while-drilling (LWD) data within gas-hydrate-bearing sand reservoirs in order to make accurate estimates of the concentration of gas hydrates under various geologic conditions and to understand the geologic controls on the occurrence of gas hydrate at each of the sites drilled during this expedition. The LWD sensors just above the drill bit provided important information on the nature of the sediments and the occurrence of gas hydrate. There has been significant advancements in the use of downhole well-logging tools to acquire detailed information on the occurrence of gas hydrate in nature: From using electrical resistivity and acoustic logs to identify gas hydrate occurrences in wells to where wireline and advanced logging-while-drilling tools are routinely used to examine the petrophysical nature of gas hydrate reservoirs and the distribution and concentration of gas hydrates within various complex reservoir systems. Recent integrated sediment coring and well-log studies have confirmed that electrical resistivity and acoustic velocity data can yield accurate gas hydrate saturations in sediment grain supported (isotropic) systems such as sand reservoirs, but more advanced log analysis models are required to characterize gas hydrate in fractured (anisotropic) reservoir systems. In support of the GOM JIP Leg II effort, well-log data montages have been compiled and presented in this report which includes downhole logs obtained from all seven wells drilled during this expedition with a focus on identifying and characterizing the potential gas-hydrate-bearing sedimentary section in each of the wells. Also presented and reviewed in this report are the gas-hydrate saturation and sediment porosity logs for each of the wells as calculated from available downhole well logs.

  12. A routine test for the relative susceptibility of potato genotypes with resistance to Meloidogyne chitwoodi

    NARCIS (Netherlands)

    Teklu, Misghina G.; Schomaker, Corrie H.; Been, Thomas H.; Molendijk, Leendert P.G.

    2016-01-01

    The population dynamics of Meloidogyne chitwoodi on eight potato genotypes was compared to the susceptible cv. Desiree in four glasshouse experiments. The initial nematode densities consisted of log series 2x , with −4 < x < 8. Seinhorst’s logistic model was fitted to the final population

  13. Query Log Analysis of an Electronic Health Record Search Engine

    Science.gov (United States)

    Yang, Lei; Mei, Qiaozhu; Zheng, Kai; Hanauer, David A.

    2011-01-01

    We analyzed a longitudinal collection of query logs of a full-text search engine designed to facilitate information retrieval in electronic health records (EHR). The collection, 202,905 queries and 35,928 user sessions recorded over a course of 4 years, represents the information-seeking behavior of 533 medical professionals, including frontline practitioners, coding personnel, patient safety officers, and biomedical researchers for patient data stored in EHR systems. In this paper, we present descriptive statistics of the queries, a categorization of information needs manifested through the queries, as well as temporal patterns of the users’ information-seeking behavior. The results suggest that information needs in medical domain are substantially more sophisticated than those that general-purpose web search engines need to accommodate. Therefore, we envision there exists a significant challenge, along with significant opportunities, to provide intelligent query recommendations to facilitate information retrieval in EHR. PMID:22195150

  14. Geophysical well logging operations and log analysis in Geothermal Well Desert Peak No. B-23-1

    Energy Technology Data Exchange (ETDEWEB)

    Sethi, D.K.; Fertl, W.H.

    1980-03-01

    Geothermal Well Desert Peak No. B-23-1 was logged by Dresser Atlas during April/May 1979 to a total depth of 2939 m (9642 ft). A temperature of 209/sup 0/C (408/sup 0/F) was observed on the maximum thermometer run with one of the logging tools. Borehole tools rated to a maximum temperature of 204.4/sup 0/C (400/sup 0/F) were utilized for logging except for the Densilog tool, which was from the other set of borehole instruments, rated to a still higher temperature, i.e., 260/sup 0/C (500/sup 0/F). The quality of the logs recorded and the environmental effects on the log response have been considered. The log response in the unusual lithologies of igneous and metamorphic formations encountered in this well could be correlated with the drill cutting data. An empirical, statistical log interpretation approach has made it possible to obtain meaningful information on the rocks penetrated. Various crossplots/histograms of the corrected log data have been generated on the computer. These are found to provide good resolution between the lithological units in the rock sequence. The crossplotting techniques and the statistical approach were combined with the drill cutting descriptions in order to arrive at the lithological characteristics. The results of log analysis and recommendations for logging of future wells have been included.

  15. Western tight gas sands advanced logging workshop proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Jennings, J B; Carroll, Jr, H B [eds.

    1982-04-01

    An advanced logging research program is one major aspect of the Western Tight Sands Program. Purpose of this workshop is to help BETC define critical logging needs for tight gas sands and to allow free interchange of ideas on all aspects of the current logging research program. Sixteen papers and abstracts are included together with discussions. Separate abstracts have been prepared for the 12 papers. (DLC)

  16. Manufacturing Hardwood Dimension Products Directly from Logs: Potential Opportunities

    Science.gov (United States)

    D. Earl Kline; Wenjie Lin; Philip A. Araman

    1993-01-01

    When a hardwood log is sawn into lumber, over 16 percent of the volume is converted to sawdust. Furthermore, 12 percent of the log is converted to slabs and 17 percent is converted to edging and trimming pieces, all of which are chipped. Hence, less than 55 percent of the log is actually converted to lumber. Lumber must meet the requirements of specific NHLA grades and...

  17. Schistosoma mansoni enhances host susceptibility to mucosal but not intravenous challenge by R5 Clade C SHIV.

    Directory of Open Access Journals (Sweden)

    Nagadenahalli B Siddappa

    2011-08-01

    Full Text Available The high prevalence of HIV-1/AIDS in areas endemic for schistosomiasis and other helminthic infections has led to the hypothesis that parasites increase host susceptibility to immunodeficiency virus infection. We previously showed that rhesus macaques (RM with active schistosomiasis were significantly more likely to become systemically infected after intrarectal (i.r. exposure to an R5-tropic clade C simian-human immunodeficiency virus (SHIV-C than were parasite-free controls. However, we could not address whether this was due to systemic or mucosal effects. If systemic immunoactivation resulted in increased susceptibility to SHIV-C acquisition, a similarly large difference in host susceptibility would be seen after intravenous (i.v. SHIV-C challenge. Conversely, if increased host susceptibility was due to parasite-induced immunoactivation at the mucosal level, i.v. SHIV-C challenge would not result in significant differences between parasitized and parasite-free monkeys.We enrolled two groups of RM and infected one group with Schistosoma mansoni; the other group was left parasite-free. Both groups were challenged i.v. with decreasing doses of SHIV-C. No statistically significant differences in 50% animal infectious doses (AID(50 or peak viremia were seen between the two groups. These data strongly contrast the earlier i.r. SHIV-C challenge (using the same virus stock in the presence/absence of parasites, where we noted a 17-fold difference in AID(50 and one log higher peak viremia in parasitized monkeys (P90% of all new HIV-1 infections worldwide are acquired through mucosal contact, parasitic infections that inflame mucosae may play an important role in the spread of HIV-1.

  18. Middle Prut plain's erosion susceptibility evaluation

    Directory of Open Access Journals (Sweden)

    Tudor CASTRAVEȚ

    2011-07-01

    Full Text Available The given article is dedicated to Middle Prut Plain’s erosion susceptibility evaluation  using factorial analysis and methodology of principal component analysis implemented byGeographical Informational System GRASS. Susceptibility evaluation is executed in a qualitative mode, and the results have preliminary character, for further quantitative andmore precise study. This type of natural hazards analysis offers information on probable localization and severity of erosion phenomena, as well as their manifestation probabilityin a given place.

  19. Using a Log Analyser to Assist Research into Haptic Technology

    Science.gov (United States)

    Jónsson, Fannar Freyr; Hvannberg, Ebba Þóra

    Usability evaluations collect subjective and objective measures. Examples of the latter are time to complete a task. The paper describes use cases of a log analyser for haptic feedback. The log analyser reads a log file and extracts information such as time of each practice and assessment session, analyses whether the user goes off curve and measures the force applied. A study case using the analyser is performed using a PHANToM haptic learning environment application that is used to teach young visually impaired students the subject of polynomials. The paper answers six questions to illustrate further use cases of the log analyser.

  20. Effects of postfire salvage logging on deadwood-associated beetles.

    Science.gov (United States)

    Cobb, T P; Morissette, J L; Jacobs, J M; Koivula, M J; Spence, J R; Langor, D W

    2011-02-01

    In Canada and the United States pressure to recoup financial costs of wildfire by harvesting burned timber is increasing, despite insufficient understanding of the ecological consequences of postfire salvage logging. We compared the species richness and composition of deadwood-associated beetle assemblages among undisturbed, recently burned, logged, and salvage-logged, boreal, mixed-wood stands. Species richness was lowest in salvage-logged stands, largely due to a negative effect of harvesting on the occurrence of wood- and bark-boring species. In comparison with undisturbed stands, the combination of wildfire and logging in salvage-logged stands had a greater effect on species composition than either disturbance alone. Strong differences in species composition among stand treatments were linked to differences in quantity and quality (e.g., decay stage) of coarse woody debris. We found that the effects of wildfire and logging on deadwood-associated beetles were synergistic, such that the effects of postfire salvage logging could not be predicted reliably on the basis of data on either disturbance alone. Thus, increases in salvage logging of burned forests may have serious negative consequences for deadwood-associated beetles and their ecological functions in early postfire successional forests. ©2010 Society for Conservation Biology.

  1. Maintaining ecosystem resilience: functional responses of tree cavity nesters to logging in temperate forests of the Americas.

    Science.gov (United States)

    Ibarra, José Tomás; Martin, Michaela; Cockle, Kristina L; Martin, Kathy

    2017-06-30

    Logging often reduces taxonomic diversity in forest communities, but little is known about how this biodiversity loss affects the resilience of ecosystem functions. We examined how partial logging and clearcutting of temperate forests influenced functional diversity of birds that nest in tree cavities. We used point-counts in a before-after-control-impact design to examine the effects of logging on the value, range, and density of functional traits in bird communities in Canada (21 species) and Chile (16 species). Clearcutting, but not partial logging, reduced diversity in both systems. The effect was much more pronounced in Chile, where logging operations removed critical nesting resources (large decaying trees), than in Canada, where decaying aspen Populus tremuloides were retained on site. In Chile, logging was accompanied by declines in species richness, functional richness (amount of functional niche occupied by species), community-weighted body mass (average mass, weighted by species densities), and functional divergence (degree of maximization of divergence in occupied functional niche). In Canada, clearcutting did not affect species richness but nevertheless reduced functional richness and community-weighted body mass. Although some cavity-nesting birds can persist under intensive logging operations, their ecosystem functions may be severely compromised unless future nest trees can be retained on logged sites.

  2. Magnetic susceptibilities of minerals

    Science.gov (United States)

    Rosenblum, Sam; Brownfield, I.K.

    2000-01-01

    Magnetic separation of minerals is a topic that is seldom reported in the literature for two reasons. First, separation data generally are byproducts of other projects; and second, this study requires a large amount of patience and is unusually tedious. Indeed, we suspect that most minerals probably are never investigated for this property. These data are timesaving for mineralogists who concentrate mono-mineralic fractions for chemical analysis, age dating, and for other purposes. The data can certainly be used in the ore-beneficiation industries. In some instances, magnetic-susceptibility data may help in mineral identification, where other information is insufficient. In past studies of magnetic separation of minerals, (Gaudin and Spedden, 1943; Tille and Kirkpatrick, 1956; Rosenblum, 1958; Rubinstein and others, 1958; Flinter, 1959; Hess, 1959; Baker, 1962; Meric and Peyre, 1963; Rojas and others, 1965; and Duchesne, 1966), the emphasis has been on the ferromagnetic and paramagnetic ranges of extraction. For readers interested in the history of magnetic separation of minerals, Krumbein and Pettijohn (1938, p. 344-346) indicated nine references back to 1848. The primary purpose of this paper is to report the magnetic-susceptibility data on as many minerals as possible, similar to tables of hardness, specific gravity, refractive indices, and other basic physical properties of minerals. A secondary purpose is to demonstrate that the total and best extraction ranges are influenced by the chemistry of the minerals. The following notes are offered to help avoid problems in separating a desired mineral concentrate from mixtures of mineral grains.

  3. Alcohol increases hypnotic susceptibility.

    Science.gov (United States)

    Semmens-Wheeler, Rebecca; Dienes, Zoltán; Duka, Theodora

    2013-09-01

    One approach to hypnosis suggests that for hypnotic experience to occur frontal lobe activity must be attenuated. For example, cold control theory posits that a lack of awareness of intentions is responsible for the experience of involuntariness and/or the subjective reality of hypnotic suggestions. The mid-dorso-lateral prefrontal cortex and the ACC are candidate regions for such awareness. Alcohol impairs frontal lobe executive function. This study examined whether alcohol affects hypnotisability. We administered 0.8 mg/kg of alcohol or a placebo to 32 medium susceptible participants. They were subsequently hypnotised and given hypnotic suggestions. All participants believed they had received some alcohol. Participants in the alcohol condition were more susceptible to hypnotic suggestions than participants in the placebo condition. Impaired frontal lobe activity facilitates hypnotic responding, which supports theories postulating that attenuation of executive function facilitates hypnotic response, and contradicts theories postulating that hypnotic response involves enhanced inhibitory, attentional or other executive function. Copyright © 2013. Published by Elsevier Inc.

  4. Development of a glacially dominated shelf-slope-fan system in tectonically active southeast Alaska: Results of IODP Expedition 341 core-log-seismic integrated studies at glacial cycle resolution

    Science.gov (United States)

    Gulick, Sean; Jaeger, John; Mix, Alan; Swartz, John; Worthington, Lindsay; Reece, Robert

    2014-05-01

    Collision of the Yakutat microplate with North American formed the St. Elias Mountains in coastal Gulf of Alaska. While the tectonic driver for orogenesis has been ongoing since the Miocene, results from the Integrated Ocean Drilling Program Expedition 341 suggests that direct climatic perturbation of active orogenesis through glacial erosion is non-linear. Geophysical studies of the glaciated continental margin, slope, and adjacent deep-sea Surveyor Fan allow examination of the glaciated orogen from source to sink. Using high-resolution and crustal-scale seismic data and through comparison with other glaciated margins, we can identify key diagnostic seismic morphologies and facies indicative of glacial proximity and sediment routing. Expedition drilling results calibrated these images suggesting a timeline for initial advances of the Cordilleran ice sheet related glacial systems onto the shelf and a further timeline for the development of ice streams that reach the shelf edge. Comparisons can be made within this single margin between evolution of the tectonic-glacial system where erosion and sediment transport are occurring within a fold and thrust belt versus on a more stable shelf region. Onshore the Bering-Bagley glacial system in the west flows across the Yakataga fold and thrust belt, allowing examination of whether glacial erosion can cause tectonic feedbacks, whereas offshore the Bering-Bagley system interacts with the Pamplona Zone thrusts in a region of significant sediment accommodation. Results from Expedition 341 imply that timing of glacial advance to the shelf edge in this region may be driven by the necessity of filling up the accommodation through aggradation followed by progradation and thus is autogenic. In contrast the Malaspina-Hubbard glacial system to the east encountered significantly less accommodation and more directly responded to climatic forcing including showing outer shelf glacial occupation since the mid-Pleistocene transition-MPT to

  5. A novel instrument for logging nearwork distance.

    Science.gov (United States)

    Leung, Tsz-wing; Flitcroft, Daniel I; Wallman, Josh; Lee, Tat Hing; Zheng, Yongping; Lam, Carly Siu-yin; Kee, Chea-su

    2011-03-01

    To validate a novel ultrasonic sensor for logging reading distances. In addition, this device was used to compare the habitual reading distances between low and high myopes. First, the stability and sensitivity of the ultrasonic device were determined by repeated measures using artificial targets. Then, thirty Hong Kong Chinese (20-30 years) were recruited, of whom fifteen were considered to be high myopes (mean ± S.D. = -8.7 ± 0.5 D) and 15 to be low to non-myopes (mean ± S.D. = -2.0 ± 0.2 D). Each subject read a newspaper with their habitual visual aid continuously for 10 min in two sessions at their preferred working distance(s). The reading distances were recorded continuously using a novel nearwork analyzer. The modal working distance was considered as the 'habitual' reading distance. In addition, habitual reading distance was reported orally by each subject. The nearwork analyzer gave accurate and repeatable measurements over a range of distances and angles. Using this instrument, high myopes were found to have a significantly shorter reading distance than low myopes or non-myopes (mean ± S.D. = 35.9 ± 9.8 cm vs 50.9 ± 24.8 cm; two-sample t-test, p = 0.04, df = 18). The reading distances reported orally by the subjects were not correlated with those recorded by the nearwork analyzer. The nearwork analyzer was found to be an effective tool for measuring nearwork reading distance in a small group of emmetropic and myopic adults over a 10 min interval. Differences between the reading distance between high myopes and low/non-myopes was detected by the device. Further study is needed to determine if a closer working distance is a cause or effect of myopia development. © 2011 The College of Optometrists.

  6. Linking downhole logging data with geology and drilling /coring operations - Example from Chicxulub Expedition 364.

    Science.gov (United States)

    Lofi, Johanna; Smith, Dave; Delahunty, Chris; Le Ber, Erwan; Mellet, Claire; Brun, Laurent; Henry, Gilles; Paris, Jehanne

    2017-04-01

    Expedition 364 was a joint IODP/ICDP mission specific platform expedition to explore the Chicxulub impact crater buried below the Yucatán continental shelf. In April and May 2016, our Expedition drilled a single borehole at Site M0077A into the crater's peak ring. It allowed recovering 303 excellent quality cores from 505.7 to 1334.7 meters below sea floor and acquiring more than 5.8 km of high resolution open hole logs. Downhole logs are rapidly collected, continuous with depth, and measured in situ; these data are classically interpreted in terms of stratigraphy, lithology, porosity, fluid content, geochemical composition and structure of the formation drilled. Downhole logs also allow assessing borehole quality (eg. shape and trajectory), and can provide assistance for decision support during drilling operations. In this work, Expedition 364 downhole logs are used to improve our understanding of the drilling/coring operation history. Differentiating between natural geological features and borehole artifacts are also critical for data quality assessment. The set of downhole geophysical tools used during Expedition 364 was constrained by the scientific objectives, drilling/coring technique, hole conditions and temperature at the drill site. Wireline logging data were acquired with slimline tools in three logging phases at intervals 0-503, 506-699 and 700-1334 mbsf. Logs were recorded either with standalone logging tools or, for the first time in IODP, with stackable slimline tools. Log data included total gamma radiation, sonic velocity, acoustic and optical borehole images, resistivity, conductivity, magnetic susceptibility, caliper and borehole fluid parameters. The majority of measurements were performed in open borehole conditions. During the drilling operations some problems were encountered directly linked to the geology of the drilled formation. For example, two zones of mud circulation losses correlate in depth with the presence of karst cavities or open

  7. Real-Time Optical Antimicrobial Susceptibility Testing

    Science.gov (United States)

    Andersen, Klaus R.; Jørgensen, Erik; Droce, Aida; Olesen, Tom; Jensen, Bent B.; Rosenvinge, Flemming S.; Sondergaard, Teis E.

    2013-01-01

    Rapid antibiotic susceptibility testing is in high demand in health care fields as antimicrobial-resistant bacterial strains emerge and spread. Here, we describe an optical screening system (oCelloScope) which, based on time-lapse imaging of 96 bacteria-antibiotic combinations at a time, introduces real-time detection of bacterial growth and antimicrobial susceptibility with imaging material to support the automatically generated graphs. Automated antibiotic susceptibility tests of a monoculture showed statistically significant antibiotic effects within 6 min and within 30 min in complex samples from pigs suffering from catheter-associated urinary tract infections. The oCelloScope system provides a fast high-throughput screening method for detecting bacterial susceptibility that might entail an earlier diagnosis and introduction of appropriate targeted therapy and thus combat the threat from multidrug-resistant pathogenic bacteria. The oCelloScope system can be employed for a broad range of applications within bacteriology and might present new vistas as a point-of-care instrument in clinical and veterinary settings. PMID:23596243

  8. Graphene susceptibility in Holstein model

    Energy Technology Data Exchange (ETDEWEB)

    Mousavi, Hamze, E-mail: hamze.mousavi@gmail.co [Department of Physics, Razi University, Kermanshah (Iran, Islamic Republic of); Nano Science and Nano Technology Research Center, Razi University, Kermanshah (Iran, Islamic Republic of)

    2011-06-15

    We study the effects of the electron-phonon interaction on the temperature dependence of the orbital magnetic susceptibility of monolayer graphene. We use the linear response theory and Green's function formalism within the Holstein Hamiltonian model. The results show that the effects of the electron-phonon interaction on the susceptibility of graphene sheet have different behaviors in two temperature regions. In the low temperature region, susceptibility increases when the electron-phonon coupling strength increases. On the other hand, the susceptibility reduces with increasing the electron-phonon coupling strength in the high temperature region. - Highlights: Effect of electron-phonon interaction on the susceptibility of graphene is studied. Linear response theory and Green's function technique in Holstein model are used. Effect of electron-phonon on susceptibility has different behaviors in two temperature regions.

  9. Topological susceptibility from slabs

    Energy Technology Data Exchange (ETDEWEB)

    Bietenholz, Wolfgang [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, A.P. 70-543, Distrito Federal, C.P. 04510 (Mexico); Forcrand, Philippe de [Institute for Theoretical Physics, ETH Zürich,CH-8093 Zürich (Switzerland); CERN, Physics Department, TH Unit, CH-1211 Geneva 23 (Switzerland); Gerber, Urs [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, A.P. 70-543, Distrito Federal, C.P. 04510 (Mexico); Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo,Edificio C-3, Apdo. Postal 2-82, Morelia, Michoacán, C.P. 58040 (Mexico)

    2015-12-14

    In quantum field theories with topological sectors, a non-perturbative quantity of interest is the topological susceptibility χ{sub t}. In principle it seems straightforward to measure χ{sub t} by means of Monte Carlo simulations. However, for local update algorithms and fine lattice spacings, this tends to be difficult, since the Monte Carlo history rarely changes the topological sector. Here we test a method to measure χ{sub t} even if data from only one sector are available. It is based on the topological charges in sub-volumes, which we denote as slabs. Assuming a Gaussian distribution of these charges, this method enables the evaluation of χ{sub t}, as we demonstrate with numerical results for non-linear σ-models.

  10. Topological Susceptibility from Slabs

    CERN Document Server

    Bietenholz, Wolfgang; Gerber, Urs

    2015-01-01

    In quantum field theories with topological sectors, a non-perturbative quantity of interest is the topological susceptibility chi_t. In principle it seems straightforward to measure chi_t by means of Monte Carlo simulations. However, for local update algorithms and fine lattice spacings, this tends to be difficult, since the Monte Carlo history rarely changes the topological sector. Here we test a method to measure chi_t even if data from only one sector are available. It is based on the topological charges in sub-volumes, which we denote as slabs. Assuming a Gaussian distribution of these charges, this method enables the evaluation of chi_t, as we demonstrate with numerical results for non-linear sigma-models.

  11. Secure optionally passive RFID tag or sensor with external power source and data logging

    Energy Technology Data Exchange (ETDEWEB)

    Nekoogar, Faranak; Reynolds, Matthew; Lefton, Scott; Dowla, Farid; Twogood, Richard

    2016-05-31

    A secure optionally passive RFID tag or sensor system comprises a passive RFID tag having means for receiving radio signals from at least one base station and for transmitting radio signals to at least one base station, where the tag is capable of being powered exclusively by received radio energy, and an external power and data logging device having at least one battery and electronic circuitry including a digital memory configured for storing and recalling data. The external power and data logging device has a means for powering the tag, and also has a means.

  12. Log-concave Probability Distributions: Theory and Statistical Testing

    DEFF Research Database (Denmark)

    An, Mark Yuing

    1996-01-01

    This paper studies the broad class of log-concave probability distributions that arise in economics of uncertainty and information. For univariate, continuous, and log-concave random variables we prove useful properties without imposing the differentiability of density functions. Discrete...

  13. 14 CFR 125.407 - Maintenance log: Airplanes.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Maintenance log: Airplanes. 125.407 Section... OPERATIONS: AIRPLANES HAVING A SEATING CAPACITY OF 20 OR MORE PASSENGERS OR A MAXIMUM PAYLOAD CAPACITY OF 6... Maintenance log: Airplanes. (a) Each person who takes corrective action or defers action concerning a reported...

  14. Veneer-log production and receipts, North Central Region, 1974.

    Science.gov (United States)

    James E. Blyth; Jerold T. Hahn

    1976-01-01

    Shows 1974 veneer-log production and receipts by species in the Lake States (Michigan, Minnesota, and Wisconsin) and in the Central States (Illinois, Indiana, Iowa, and Missouri). Comparisons are made with similar data for 1972. Includes tables showing veneer-log production and receipts (for selected years) since 1946 in the Lake States and since 1956 in the Central...

  15. Veneer-log production and receipts, North Central Region, 1976.

    Science.gov (United States)

    James E. Blyth; Jerold T. Hahn

    1978-01-01

    Shows 1976 veneer-log production and receipts by species in the Lake States (Michigan, Minnesota, and Wisconsin) and in the Central States (Illinois, Indiana, Iowa, and Missouri). Comparisons are made with similar data for 1974. Includes tables showing veneer-log production and receipts (for selected years) since 1946 in the Lake States and since 1956 in the Central...

  16. Evaluation of logging impacts on tropical rainforest in Eastern ...

    African Journals Online (AJOL)

    Various strategies and techniques have been designed and implemented to study the effects of logging activities on tropical rainforest amongst which remote sensing and GIS analysis. But there are still few measures available on the effects of industrial timber on forest ecosystem. This paper examined the impact of logging ...

  17. The application of seismic-log sequence stratigraphy in mapping ...

    African Journals Online (AJOL)

    The concept of seismic-log sequence stratigraphy was used in mapping stratigraphic traps and reservoirs' facies in Afam Channel area, Niger Delta, for the purpose of prospect re-evaluation and improving production. The data set consists of 3-D seismic data and conventional well logs, which were interpreted iteratively ...

  18. 29 CFR 1401.32 - Logging of written requests.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Logging of written requests. 1401.32 Section 1401.32 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE PUBLIC INFORMATION Production or Disclosure of Information § 1401.32 Logging of written requests. (a) All requests for records...

  19. 14 CFR 60.20 - Logging FSTD discrepancies.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Logging FSTD discrepancies. 60.20 Section 60.20 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.20 Logging...

  20. 33 CFR 207.370 - Big Fork River, Minn.; logging.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Big Fork River, Minn.; logging. 207.370 Section 207.370 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE NAVIGATION REGULATIONS § 207.370 Big Fork River, Minn.; logging. (a) During the season...

  1. Impacts of salvage logging on biodiversity: a meta-analysis.

    Science.gov (United States)

    Thorn, Simon; Bässler, Claus; Brandl, Roland; Burton, Philip J; Cahall, Rebecca; Campbell, John L; Castro, Jorge; Choi, Chang-Yong; Cobb, Tyler; Donato, Daniel C; Durska, Ewa; Fontaine, Joseph B; Gauthier, Sylvie; Hebert, Christian; Hothorn, Torsten; Hutto, Richard L; Lee, Eun-Jae; Leverkus, Alexandro B; Lindenmayer, David B; Obrist, Martin K; Rost, Josep; Seibold, Sebastian; Seidl, Rupert; Thom, Dominik; Waldron, Kaysandra; Wermelinger, Beat; Winter, Maria-Barbara; Zmihorski, Michal; Müller, Jörg

    2018-01-01

    Logging to "salvage" economic returns from forests affected by natural disturbances has become increasingly prevalent globally. Despite potential negative effects on biodiversity, salvage logging is often conducted, even in areas otherwise excluded from logging and reserved for nature conservation, inter alia because strategic priorities for post-disturbance management are widely lacking.A review of the existing literature revealed that most studies investigating the effects of salvage logging on biodiversity have been conducted less than 5 years following natural disturbances, and focused on non-saproxylic organisms.A meta-analysis across 24 species groups revealed that salvage logging significantly decreases numbers of species of eight taxonomic groups. Richness of dead wood dependent taxa (i.e. saproxylic organisms) decreased more strongly than richness of non-saproxylic taxa. In contrast, taxonomic groups typically associated with open habitats increased in the number of species after salvage logging.By analysing 134 original species abundance matrices, we demonstrate that salvage logging significantly alters community composition in 7 of 17 species groups, particularly affecting saproxylic assemblages.Synthesis and applications. Our results suggest that salvage logging is not consistent with the management objectives of protected areas. Substantial changes, such as the retention of dead wood in naturally disturbed forests, are needed to support biodiversity. Future research should investigate the amount and spatio-temporal distribution of retained dead wood needed to maintain all components of biodiversity.

  2. Butt-log grade distributions for five Appalachian hardwood species

    Science.gov (United States)

    John R. Myers; Gary W. Miller; Harry V., Jr. Wiant; Joseph E. Barnard; Joseph E. Barnard

    1986-01-01

    Tree quality is an important factor in determining the market value of hardwood timber stands, but many forest inventories do not include estimates of tree quality. Butt-log grade distributions were developed for northern red oak, black oak, white oak, chestnut oak, and yellow-poplar using USDA Forest Service log grades on more than 4,700 trees in West Virginia. Butt-...

  3. Landslides after clearcut logging in a coast redwood forest

    Science.gov (United States)

    Leslie M. Reid; Elizabeth T. Keppeler

    2012-01-01

    Landslides have been mapped at least annually in the 473 ha North Fork Caspar Creek watershed since 1985, allowing evaluation of landslide distribution, characteristics, and rates associated with second-entry partial clearcut logging of 1989 to 1992. Comparison of sliding rates in logged and forested areas shows no appreciable difference for streamside slides (size...

  4. Teaching an Old Log New Tricks with Machine Learning.

    Science.gov (United States)

    Schnell, Krista; Puri, Colin; Mahler, Paul; Dukatz, Carl

    2014-03-01

    To most people, the log file would not be considered an exciting area in technology today. However, these relatively benign, slowly growing data sources can drive large business transformations when combined with modern-day analytics. Accenture Technology Labs has built a new framework that helps to expand existing vendor solutions to create new methods of gaining insights from these benevolent information springs. This framework provides a systematic and effective machine-learning mechanism to understand, analyze, and visualize heterogeneous log files. These techniques enable an automated approach to analyzing log content in real time, learning relevant behaviors, and creating actionable insights applicable in traditionally reactive situations. Using this approach, companies can now tap into a wealth of knowledge residing in log file data that is currently being collected but underutilized because of its overwhelming variety and volume. By using log files as an important data input into the larger enterprise data supply chain, businesses have the opportunity to enhance their current operational log management solution and generate entirely new business insights-no longer limited to the realm of reactive IT management, but extending from proactive product improvement to defense from attacks. As we will discuss, this solution has immediate relevance in the telecommunications and security industries. However, the most forward-looking companies can take it even further. How? By thinking beyond the log file and applying the same machine-learning framework to other log file use cases (including logistics, social media, and consumer behavior) and any other transactional data source.

  5. Secure Audit Logging with Tamper-Resistant Hardware

    NARCIS (Netherlands)

    Chong, C.N.; Peng, Z.; Peng, Z.; Hartel, Pieter H.; Gritzalis, D.; De Capitani di Vimercati, S.; Katsikas, S.K.; Samarati, P.

    Secure perimeter schemes (e.g. DRM) and tracing traitor schemes (e.g. watermarking, audit logging) strive to mitigate the problems of content escaping the control of the rights holder. Secure audit logging records the user's actions on content and enables detection of some forms of tampering with

  6. British Columbia log export policy: historical review and analysis.

    Science.gov (United States)

    Craig W. Shinn

    1993-01-01

    Log exports have been restricted in British Columbia for over 100 years. The intent of the restriction is to use the timber in British Columbia to encourage development of forest industry, employment, and well-being in the Province. Logs have been exempted from the within-Province manufacturing rule at various times, in varying amounts, for different reasons, and by...

  7. Log production in Washington and Oregon: an historical perspective.

    Science.gov (United States)

    Brian R. Wall

    1972-01-01

    In the history of the Pacific Northwest, log production and conversion have been major economic activities. The long-term trends in timber harvesting have been upward, and most of the harvest has come from large old-growth forest inventories. National and international demands for timber have been a major element in putting upward pressure on log production levels....

  8. Producing Hardwood Dimension Parts Directly From Logs: An Economic Feasibility Study

    Science.gov (United States)

    Wenjie Lin; D. Earl Kline; Philip A. Araman; Janice K. Wiedenbeck

    1995-01-01

    The economic feasibility and profitability of a direct processing system for converting Factory Grades 2 and 3 red oak logs directly into rough dimension parts were evaluated. New present value (NPV) and internal rate of return (IRR) were used as the measurement of economic feasibility, and return on sales (ROS) was used as the measurement of profitability. NPV and IRR...

  9. Three-dimensional microwave imaging for breast-cancer detection using the log-phase formulation

    DEFF Research Database (Denmark)

    Rubæk, Tonny; Meincke, Peter; Kim, Oleksiy S.

    2007-01-01

    The log-phase formulation is applied for the reconstruction of images from a simulation of a three-dimensional imaging system. By using this formulation, a clear improvement in the quality of the reconstructed images is achieved compared to the case in which the usual complex phasor notation...

  10. Combined eyetracking and keystroke-logging methods for studying cognitive processes in text production.

    Science.gov (United States)

    Wengelin, Asa; Torrance, Mark; Holmqvist, Kenneth; Simpson, Sol; Galbraith, David; Johansson, Victoria; Johansson, Roger

    2009-05-01

    Writers typically spend a certain proportion of time looking back over the text that they have written. This is likely to serve a number of different functions, which are currently poorly understood. In this article, we present two systems, ScriptLog+ TimeLine and EyeWrite, that adopt different and complementary approaches to exploring this activity by collecting and analyzing combined eye movement and keystroke data from writers composing extended texts. ScriptLog+ TimeLine is a system that is based on an existing keystroke-logging program and uses heuristic, pattern-matching methods to identify reading episodes within eye movement data. EyeWrite is an integrated editor and analysis system that permits identification of the words that the writer fixates and their location within the developing text. We demonstrate how the methods instantiated within these systems can be used to make sense of the large amount of data generated by eyetracking and keystroke logging in order to inform understanding of the cognitive processes that underlie written text production.

  11. Particle Filter ROV Navigation using Hydrodynamic Position and Speed log Measurements

    DEFF Research Database (Denmark)

    Zhao, Bo; Blanke, Mogens; Skjetne, Roger

    2012-01-01

    An integrated navigation system design is presented for an underwater remotely operated vehicle (ROV). The available navigation information is an acoustic position measurement and a Doppler log speed measurement. Both measurements are studied in detail and modeled statistically. A kinematic model...

  12. Production speed effects on log-making error rates and value ...

    African Journals Online (AJOL)

    Mechanized processing operations are complex “man-machine” systems. The impacts of changes to work practices are, therefore, dependent on the effects the changes have on both the machine and the man. A mechanized processor, delimbing and cutting tree length stems into logs on a landing, was studied in two Pinus ...

  13. Practical Aspects of Log-ratio Coordinate Representations in Regression with Compositional Response

    Directory of Open Access Journals (Sweden)

    Fišerová Eva

    2016-10-01

    Full Text Available Regression analysis with compositional response, observations carrying relative information, is an appropriate tool for statistical modelling in many scientific areas (e.g. medicine, geochemistry, geology, economics. Even though this technique has been recently intensively studied, there are still some practical aspects that deserve to be further analysed. Here we discuss the issue related to the coordinate representation of compositional data. It is shown that linear relation between particular orthonormal coordinates and centred log-ratio coordinates can be utilized to simplify the computation concerning regression parameters estimation and hypothesis testing. To enhance interpretation of regression parameters, the orthogonal coordinates and their relation with orthonormal and centred log-ratio coordinates are presented. Further we discuss the quality of prediction in different coordinate system. It is shown that the mean squared error (MSE for orthonormal coordinates is less or equal to the MSE for log-transformed data. Finally, an illustrative real-world example from geology is presented.

  14. Practical Aspects of Log-ratio Coordinate Representations in Regression with Compositional Response

    Science.gov (United States)

    Fišerová, Eva; Donevska, Sandra; Hron, Karel; Bábek, Ondřej; Vaňkátová, Kristýna

    2016-10-01

    Regression analysis with compositional response, observations carrying relative information, is an appropriate tool for statistical modelling in many scientific areas (e.g. medicine, geochemistry, geology, economics). Even though this technique has been recently intensively studied, there are still some practical aspects that deserve to be further analysed. Here we discuss the issue related to the coordinate representation of compositional data. It is shown that linear relation between particular orthonormal coordinates and centred log-ratio coordinates can be utilized to simplify the computation concerning regression parameters estimation and hypothesis testing. To enhance interpretation of regression parameters, the orthogonal coordinates and their relation with orthonormal and centred log-ratio coordinates are presented. Further we discuss the quality of prediction in different coordinate system. It is shown that the mean squared error (MSE) for orthonormal coordinates is less or equal to the MSE for log-transformed data. Finally, an illustrative real-world example from geology is presented.

  15. Work-related injuries in the Alaska logging industry, 1991-2014.

    Science.gov (United States)

    Springer, Yuri P; Lucas, Devin L; Castrodale, Louisa J; McLaughlin, Joseph B

    2018-01-01

    Although loggers in Alaska are at high risk for occupational injury, no comprehensive review of such injuries has been performed since the mid-1990s. We investigated work-related injuries in the Alaska logging industry during 1991-2014. Using data from the Alaska Trauma Registry and the Alaska Occupational Injury Surveillance System, we described fatal and nonfatal injuries by factors including worker sex and age, timing and geographic location of injuries, and four injury characteristics. Annual injury rates and associated 5-year simple moving averages were calculated. We identified an increase in the 5-year simple moving averages of fatal injury rates beginning around 2005. While injury characteristics were largely consistent between the first 14 and most recent 10 years of the investigation, the size of logging companies declined significantly between these periods. Factors associated with declines in the size of Alaska logging companies might have contributed to the observed increase in fatal injury rates. © 2017 Wiley Periodicals, Inc.

  16. Development of Cross-Platform Software for Well Logging Data Visualization

    Science.gov (United States)

    Akhmadulin, R. K.; Miraev, A. I.

    2017-07-01

    Well logging data processing is one of the main sources of information in the oil-gas field analysis and is of great importance in the process of its development and operation. Therefore, it is important to have the software which would accurately and clearly provide the user with processed data in the form of well logs. In this work, there have been developed a software product which not only has the basic functionality for this task (loading data from .las files, well log curves display, etc.), but can be run in different operating systems and on different devices. In the article a subject field analysis and task formulation have been performed, and the software design stage has been considered. At the end of the work the resulting software product interface has been described.

  17. Cased-hole log analysis and reservoir performance monitoring

    CERN Document Server

    Bateman, Richard M

    2015-01-01

    This book addresses vital issues, such as the evaluation of shale gas reservoirs and their production. Topics include the cased-hole logging environment, reservoir fluid properties; flow regimes; temperature, noise, cement bond, and pulsed neutron logging; and casing inspection. Production logging charts and tables are included in the appendices. The work serves as a comprehensive reference for production engineers with upstream E&P companies, well logging service company employees, university students, and petroleum industry training professionals. This book also: ·       Provides methods of conveying production logging tools along horizontal well segments as well as measurements of formation electrical resistivity through casing ·       Covers new information on fluid flow characteristics in inclined pipe and provides new and improved nuclear tool measurements in cased wells ·       Includes updates on cased-hole wireline formation testing  

  18. A regularity-based modeling of oil borehole logs

    Science.gov (United States)

    Gaci, Said; Zaourar, Naima

    2013-04-01

    Multifractional Brownian motions (mBms) are successfully used to describe borehole logs behavior. These local fractal models allow to investigate the depth-evolution of regularity of the logs, quantified by the Hölder exponent (H). In this study, a regularity analysis is carried out on datasets recorded in Algerian oil boreholes located in different geological settings. The obtained regularity profiles show a clear correlation with lithology. Each lithological discontinuity corresponds to a jump in H value. Moreover, for a given borehole, all the regularity logs are significantly correlated and lead to similar lithological segmentations. Therefore, the Hölderian regularity is a robust property which can be used to characterize lithological heterogeneities. However, this study does not draw any relation between the recorded physical property and its estimated regularity degree for all the analyzed logs. Keywords: well logs, regularity, Hölder exponent, multifractional Brownian motion

  19. Influence of borehole-eccentred tools on wireline and logging-while-drilling sonic logging measurements

    KAUST Repository

    Pardo, David

    2013-02-13

    We describe a numerical study to quantify the influence of tool-eccentricity on wireline (WL) and logging-while-drilling (LWD) sonic logging measurements. Simulations are performed with a height-polynomial-adaptive (hp) Fourier finite-element method that delivers highly accurate solutions of linear visco-elasto-acoustic problems in the frequency domain. The analysis focuses on WL instruments equipped with monopole or dipole sources and LWD instruments with monopole excitation. Analysis of the main propagation modes obtained from frequency dispersion curves indicates that the additional high-order modes arising as a result of borehole-eccentricity interfere with the main modes (i.e., Stoneley, pseudo-Rayleigh and flexural). This often modifies (decreases) the estimation of shear and compressional formation velocities, which should be corrected (increased) to account for borehole-eccentricity effects. Undesired interferences between different modes can occur at different frequencies depending upon the properties of the formation and fluid annulus size, which may difficult the estimation of the formation velocities. © 2013 European Association of Geoscientists & Engineers.

  20. An {Omega}({radical}log log n) lower bound for routing in optical networks

    Energy Technology Data Exchange (ETDEWEB)

    Goldberg, L.A. [Sandia National Labs., Albuquerque, NM (United States); Jerrum, M. [Edinburgh Univ. (United Kingdom). Dept. of Computer Science; MacKenzie, P.D. [Texas Univ., Austin, TX (United States). Dept. of Computer Sciences

    1993-11-06

    Optical communication is likely to significantly speed up parallel computation because the vast bandwidth of the optical medium can be divided to produce communication networks of very high degree. However, the problem of contention in high-degree networks makes the routing problem in these networks theoretically (and practically) difficult. In this paper we examine Valiant`s h-relation routing problem, which is a fundamental problem in the theory of parallel computing. The h-relation routing problem arises both in the direct implementation of specific parallel algorithms on distributed-memory machines and in the general simulation of shared memory models such as the PRAM on distributed-memory machines. In an h-relation routing problem each processor has up to h messages that it wishes to send to other processors and each processor is the destination of at most h messages. We present a lower bound for routing an h-relation (for any h > 1) on a complete optical network of size -n. Our lower bound applies to any randomized distributed algorithm for this task. Specifically, we show that the expected number of communication steps required to route an arbitrary h-relation is {Omega}(h + {radical}log log n). This is the first known lower bound for this problem which does not restrict the class of algorithms under consideration.