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Sample records for susceptibility assay mods

  1. Microscopic observation drug susceptibility assay (MODS for early diagnosis of tuberculosis in children.

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    Dang Thi Minh Ha

    2009-12-01

    Full Text Available MODS is a novel liquid culture based technique that has been shown to be effective and rapid for early diagnosis of tuberculosis (TB. We evaluated the MODS assay for diagnosis of TB in children in Viet Nam. 217 consecutive samples including sputum (n = 132, gastric fluid (n = 50, CSF (n = 32 and pleural fluid (n = 3 collected from 96 children with suspected TB, were tested by smear, MODS and MGIT. When test results were aggregated by patient, the sensitivity and specificity of smear, MGIT and MODS against "clinical diagnosis" (confirmed and probable groups as the gold standard were 28.2% and 100%, 42.3% and 100%, 39.7% and 94.4%, respectively. The sensitivity of MGIT and MODS was not significantly different in this analysis (P = 0.5, but MGIT was more sensitive than MODS when analysed on the sample level using a marginal model (P = 0.03. The median time to detection of MODS and MGIT were 8 days and 13 days, respectively, and the time to detection was significantly shorter for MODS in samples where both tests were positive (P<0.001. An analysis of time-dependent sensitivity showed that the detection rates were significantly higher for MODS than for MGIT by day 7 or day 14 (P<0.001 and P = 0.04, respectively. MODS is a rapid and sensitive alternative method for the isolation of M.tuberculosis from children.

  2. Reliability of the MODS assay decentralisation process in three health regions in Peru

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    Mendoza, A.; Castillo, E.; Gamarra, N.; Huamán, T.; Perea, M.; Monroi, Y.; Salazar, R.; Coronel, J.; Acurio, M.; Obregón, G.; Roper, M.; Bonilla, C.; Asencios, L.; Moore, D. A. J.

    2011-01-01

    OBJECTIVE To deliver rapid isoniazid (INH) and rifampicin (RMP) drug susceptibility testing (DST) close to the patient, we designed a decentralisation process for the microscopic observation drug susceptibility (MODS) assay in Peru and evaluated its reliability. METHODS After 2 weeks of training, laboratory staff processed ≥120 consecutive sputum samples each in three regional laboratories. Samples were processed in parallel with MODS testing at an expert laboratory. Blinded paired results were independently analysed by the Instituto Nacional de Salud (INS) according to predetermined criteria: concordance for culture, DST against INH and RMP and diagnosis of multidrug-resistant t uberculosis (MDR-TB) ≥ 95%, McNemar's P > 0.05, kappa index (κ) ≥ 0.75 and contamination 1–4%. Sensitivity and specificity for MDR-TB were calculated. RESULTS The accreditation process for Callao (126 samples, 79.4% smear-positive), Lima Sur (n = 130, 84%) and Arequipa (n = 126, 80%) took respectively 94, 97 and 173 days. Pre-determined criteria in all regional laboratories were above expected values. The sensitivity and specificity for detecting MDR-TB in regional laboratories were >95%, except for sensitivity in Lima Sur, which was 91.7%. Contamination was 1.0–2.3%. Mean delay to positive MODS results was 9.9–12.9 days. CONCLUSION Technology transfer of MODS was reliable, effective and fast, enabling the INS to accredit regional laboratories swiftly. PMID:21219684

  3. Evaluating the Auto-MODS Assay, a Novel Tool for Tuberculosis Diagnosis for Use in Resource-Limited Settings

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    Wang, Linwei; Mohammad, Sohaib H.; Li, Qiaozhi; Rienthong, Somsak; Rienthong, Dhanida; Nedsuwan, Supalert; Mahasirimongkol, Surakameth; Yasui, Yutaka

    2014-01-01

    There is an urgent need for simple, rapid, and affordable diagnostic tests for tuberculosis (TB) to combat the great burden of the disease in developing countries. The microscopic observation drug susceptibility assay (MODS) is a promising tool to fill this need, but it is not widely used due to concerns regarding its biosafety and efficiency. This study evaluated the automated MODS (Auto-MODS), which operates on principles similar to those of MODS but with several key modifications, making it an appealing alternative to MODS in resource-limited settings. In the operational setting of Chiang Rai, Thailand, we compared the performance of Auto-MODS with the gold standard liquid culture method in Thailand, mycobacterial growth indicator tube (MGIT) 960 plus the SD Bioline TB Ag MPT64 test, in terms of accuracy and efficiency in differentiating TB and non-TB samples as well as distinguishing TB and multidrug-resistant (MDR) TB samples. Sputum samples from clinically diagnosed TB and non-TB subjects across 17 hospitals in Chiang Rai were consecutively collected from May 2011 to September 2012. A total of 360 samples were available for evaluation, of which 221 (61.4%) were positive and 139 (38.6%) were negative for mycobacterial cultures according to MGIT 960. Of the 221 true-positive samples, Auto-MODS identified 212 as positive and 9 as negative (sensitivity, 95.9%; 95% confidence interval [CI], 92.4% to 98.1%). Of the 139 true-negative samples, Auto-MODS identified 135 as negative and 4 as positive (specificity, 97.1%; 95% CI, 92.8% to 99.2%). The median time to culture positivity was 10 days, with an interquartile range of 8 to 13 days for Auto-MODS. Auto-MODS is an effective and cost-sensitive alternative diagnostic tool for TB diagnosis in resource-limited settings. PMID:25378569

  4. Evaluation of the microscopic observational drug susceptibility assay for rapid and efficient diagnosis of multi-drug resistant tuberculosis

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    R P Lazarus

    2012-01-01

    Full Text Available Purpose: Tuberculosis (TB is endemic in India and the burden of multi-drug-resistant tuberculosis (MDR-TB is high. Early detection of MDR-TB is of primary importance in controlling the spread of TB. The microscopic observational drug susceptibility (MODS assay has been described as a cost-effective and rapid method by which mycobacterial culture and the drug susceptibility test (DST can be done at the same time. Materials and Methods: A total of 302 consecutive sputum samples that were received in an accredited mycobacteriology laboratory for conventional culture and DST were evaluated by the MODS assay. Results: In comparison with conventional culture on Lowenstein Jensen (LJ media, the MODS assay showed a sensitivity of 94.12% and a specificity of 89.39% and its concordance with the DST by the proportion method on LJ media to isoniazid and rifampicin was 90.8% and 91.5%, respectively. The turnaround time for results by MODS was 9 days compared to 21 days by culture on LJ media and an additional 42 days for DST by the 1% proportion method. The cost of performing a single MODS assay was Rs. 250/-, compared to Rs. 950/- for culture and 1st line DST on LJ. Conclusion: MODS was found to be a sensitive and rapid alternative method for performing culture and DST to identify MDR-TB in resource poor settings.

  5. The value of microscopic-observation drug susceptibility assay in the diagnosis of tuberculosis and detection of multidrug resistance.

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    Sertel Şelale, Denİz; Uzun, Meltem

    2018-01-01

    Inexpensive, rapid, and reliable tests for detecting the presence and drug susceptibility of Mycobacterium tuberculosis complex (MTBC) are urgently needed to control the transmission of tuberculosis. In this study, we aimed to assess the accuracy and speed of the microscopic-observation drug susceptibility (MODS) assay in the identification of MTBC and detection of multidrug resistance. Sputum samples from patients suspected to have tuberculosis were simultaneously tested with MODS and conventional culture [Löwenstein-Jensen (LJ) culture, BACTEC MGIT™ 960 (MGIT) system], and drug susceptibility testing (MGIT system) methods. A total of 331 sputum samples were analyzed. Sensitivity and specificity of MODS assay for detection of MTBC strains were 96% and 98.8%, respectively. MODS assay detected multidrug resistant MTBC isolates with 92.3% sensitivity and 96.6% specificity. Median time to culture positivity was similar for MGIT (8 days) and MODS culture (8 days), but was significantly longer with LJ culture (20 days) (p tuberculosis and detection of multidrug resistance. © 2017 APMIS. Published by John Wiley & Sons Ltd.

  6. Direct nitrate reductase assay versus microscopic observation drug susceptibility test for rapid detection of MDR-TB in Uganda.

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    Freddie Bwanga

    Full Text Available The most common method for detection of drug resistant (DR TB in resource-limited settings (RLSs is indirect susceptibility testing on Lowenstein-Jensen medium (LJ which is very time consuming with results available only after 2-3 months. Effective therapy of DR TB is therefore markedly delayed and patients can transmit resistant strains. Rapid and accurate tests suitable for RLSs in the diagnosis of DR TB are thus highly needed. In this study we compared two direct techniques--Nitrate Reductase Assay (NRA and Microscopic Observation Drug Susceptibility (MODS for rapid detection of MDR-TB in a high burden RLS. The sensitivity, specificity, and proportion of interpretable results were studied. Smear positive sputum was collected from 245 consecutive re-treatment TB patients attending a TB clinic in Kampala, Uganda. Samples were processed at the national reference laboratory and tested for susceptibility to rifampicin and isoniazid with direct NRA, direct MODS and the indirect LJ proportion method as reference. A total of 229 specimens were confirmed as M. tuberculosis, of these interpretable results were obtained in 217 (95% with either the NRA or MODS. Sensitivity, specificity and kappa agreement for MDR-TB diagnosis was 97%, 98% and 0.93 with the NRA; and 87%, 95% and 0.78 with the MODS, respectively. The median time to results was 10, 7 and 64 days with NRA, MODS and the reference technique, respectively. The cost of laboratory supplies per sample was low, around 5 USD, for the rapid tests. The direct NRA and MODS offered rapid detection of resistance almost eight weeks earlier than with the reference method. In the study settings, the direct NRA was highly sensitive and specific. We consider it to have a strong potential for timely detection of MDR-TB in RLS.

  7. Application of luciferase assay for ATP to antimicrobial drug susceptibility

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    Chappelle, E. W.; Picciolo, G. L.; Vellend, H.; Tuttle, S. A.; Barza, M. J.; Weinstein, L. (Inventor)

    1977-01-01

    The susceptibility of bacteria, particularly those derived from body fluids, to antimicrobial agents is determined in terms of an ATP index measured by culturing a bacterium in a growth medium. The amount of ATP is assayed in a sample of the cultured bacterium by measuring the amount of luminescent light emitted when the bacterial ATP is reacted with a luciferase-luciferin mixture. The sample of the cultured bacterium is subjected to an antibiotic agent. The amount of bacterial adenosine triphosphate is assayed after treatment with the antibiotic by measuring the luminescent light resulting from the reaction. The ATP index is determined from the values obtained from the assay procedures.

  8. Evaluation of Microscopic Observation Drug Susceptibility (MODS) and the string test for rapid diagnosis of pulmonary tuberculosis in HIV/AIDS patients in Bolivia.

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    Lora, Meredith H; Reimer-McAtee, Melissa J; Gilman, Robert H; Lozano, Daniel; Saravia, Ruth; Pajuelo, Monica; Bern, Caryn; Castro, Rosario; Espinoza, Magaly; Vallejo, Maya; Solano, Marco; Challapa, Roxana; Torrico, Faustino

    2015-06-06

    Tuberculosis (TB) is the most common opportunistic infection and the leading cause of death in HIV-positive people worldwide. Diagnosing TB is difficult, and is more challenging in resource-scarce settings where culture-based diagnostic methods rely on poorly sensitive smear microscopy by Ziehl-Neelsen stain (ZN). We performed a cross-sectional study examining the diagnostic utility of Microscopic Observation Drug Susceptibility liquid culture (MODS) versus traditional Ziehl-Neelsen staining (ZN) and Lowenstein Jensen culture (LJ) of pulmonary tuberculosis (TB) and multidrug-resistant tuberculosis (MDRTB) in HIV-infected patients in Bolivia. For sputum scarce individuals we assessed the value of the string test and induced sputum for TB diagnosis. The presence of Mycobacterium tuberculosis (Mtb) in the sputum of 107 HIV-positive patients was evaluated by ZN, LJ, and MODS. Gastric secretion samples obtained by the string test were evaluated by MODS in 102 patients. The TB-HIV co-infection rate of HIV patients with respiratory symptoms by sputum sample was 45 % (48/107); 46/48 (96 %) were positive by MODS, 38/48 (79 %) by LJ, and 30/48 (63 %) by ZN. The rate of MDRTB was 9 % (4/48). Median time to positive culture was 10 days by MODS versus 34 days by LJ (p Bolivia.

  9. Microscopic observation drug-susceptibility assay vs. Xpert® MTB/RIF for the diagnosis of tuberculosis in a rural African setting: a cost-utility analysis.

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    Wikman-Jorgensen, Philip E; Llenas-García, Jara; Pérez-Porcuna, Tomàs M; Hobbins, Michael; Ehmer, Jochen; Mussa, Manuel A; Ascaso, Carlos

    2017-06-01

    To compare the cost-utility of microscopic observation drug-susceptibility assay (MODS) and Xpert ® MTB/RIF implementation for tuberculosis (TB) diagnosis in rural northern Mozambique. Stochastic transmission compartmental TB model from the healthcare provider perspective with parameter input from direct measurements, systematic literature reviews and expert opinion. MODS and Xpert ® MTB/RIF were evaluated as replacement test of smear microscopy (SM) or as an add-on test after a negative SM. Costs were calculated in 2013 USD, effects in disability-adjusted life years (DALY). Willingness to pay threshold (WPT) was established at once the per capita Gross National Income of Mozambique. MODS as an add-on test to negative SM produced an incremental cost-effectiveness ratio (ICER) of 5647.89USD/DALY averted. MODS as a substitute for SM yielded an ICER of 5374.58USD/DALY averted. Xpert ® MTB/RIF as an add-on test to negative SM yielded ICER of 345.71USD/DALY averted. Xpert ® MTB/RIF as a substitute for SM obtained an ICER of 122.13USD/DALY averted. TB prevalence and risk of infection were the main factors impacting MODS and Xpert ® MTB/RIF ICER in the one-way sensitivity analysis. In the probabilistic sensitivity analysis, Xpert ® MTB/RIF was most likely to have an ICER below the WPT, whereas MODS was not. Our cost-utility analysis favours the implementation of Xpert ® MTB/RIF as a replacement of SM for all TB suspects in this rural high TB/HIV prevalence African setting. © 2017 John Wiley & Sons Ltd.

  10. Extended biofilm susceptibility assay for Staphylococcus aureus bovine mastitis isolates: evidence for association between genetic makeup and biofilm susceptibility.

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    Melchior, M B; van Osch, M H J; Lam, T J G M; Vernooij, J C M; Gaastra, W; Fink-Gremmels, J

    2011-12-01

    Staphylococcus aureus is one of the most prevalent causes of bovine mastitis. The antimicrobial treatment of this disease is currently based on antimicrobial susceptibility tests according to Clinical and Laboratory Standards Institute standards. However, various authors have shown a discrepancy between the results of this standard susceptibility test and the actual cure rate of the applied antimicrobial treatment. Increasing evidence suggests that in vivo biofilm formation by Staph. aureus, which is not assessed in the antimicrobial susceptibility tests, is associated with this problem, resulting in disappointing cure rates, especially for infections of longer duration. Previous data obtained with a limited number of strains showed that the extended biofilm antimicrobial susceptibility (EBS) assay reveals differences between strains, which cannot be derived from a standard susceptibility test or from a 24-h biofilm susceptibility test. The objective of this study was to test a collection of Staph. aureus bovine mastitis strains in the EBS assay and to model the effect of antimicrobial exposure, duration of antimicrobial exposure, and genotype profile of the strains on antimicrobial susceptibility. With the results from a previous study with the same collection of strains, the effect of genotype represented by accessory gene regulator gene (agr-type), the presence of insertional sequence 257 (IS257), intercellular adhesion (ica), and the β-lactamase (blaZ) gene were entered as explanatory factors in a logistic regression model. The agr locus of Staph. aureus controls the expression of most of the virulence factors, represses the transcription of several cell wall-associated proteins, and activates several exoproteins during the post-exponential phase. The IS257 gene has been related to biofilm formation in vitro and was found earlier in 50% of the agr-type 2 strains. The ica gene cluster encodes for the production of an extracellular polysaccharide adhesin, termed

  11. Rapid susceptibility testing of Mycobacterium tuberculosis by bioluminescence assay of mycobacterial ATP

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    Nilsson, L.E.; Hoffner, S.E.; Ansehn, S.

    1988-01-01

    Mycobacterial growth was monitored by bioluminescence assay of mycobacterial ATP. Cultures of Mycobacterium tuberculosis H37Rv and of 25 clinical isolates of the same species were exposed to serial dilutions of ethambutol, isoniazid, rifampin, and streptomycin. A suppression of ATP, indicating growth inhibition, occurred for susceptible but not resistant strains within 5 to 7 days of incubation. Breakpoint concentrations between susceptibility and resistance were determined by comparing these results with those obtained by reference techniques. Full agreement was found in 99% of the assays with the resistance ratio method on Lowenstein-Jensen medium, and 98% of the assays were in full agreement with the radiometric system (BACTEC). A main advantage of the bioluminescence method is its rapidity, with results available as fast as with the radiometric system but at a lower cost and without the need for radioactive culture medium. The method provides kinetic data concerning drug effects within available in vivo drug concentrations and has great potential for both rapid routine susceptibility testing and research applications in studies of drug effects on mycobacteria

  12. A dual reporter cell assay for identifying serotype and drug susceptibility of herpes simplex virus.

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    Lu, Wen-Wen; Sun, Jun-Ren; Wu, Szu-Sian; Lin, Wan-Hsuan; Kung, Szu-Hao

    2011-08-15

    A dual reporter cell assay (DRCA) that allows real-time detection of herpes simplex virus (HSV) infection was developed. This was achieved by stable transfection of cells with an expression cassette that contains the dual reporter genes, secreted alkaline phosphatase (SEAP) and enhanced green fluorescent protein (EGFP), under the control of an HSV early gene promoter. Baby hamster kidney (BHK) and Chinese hamster ovary (CHO) cell lines were used as parental cell lines because the former is permissive for both HSV serotypes, HSV-1 and HSV-2, whereas the latter is susceptible to infection only by HSV-2. The DRCA permitted differential detection of HSV-1 and HSV-2 by observation of EGFP-positive cells, as substantiated by screening a total of 35 samples. The BHK-based cell line is sensitive to a viral titer as low as a single plaque-forming unit with a robust assay window as measured by a chemiluminescent assay. Evaluations of the DRCA with representative acyclovir-sensitive and acyclovir-resistant HSV strains demonstrated that their drug susceptibilities were accurately determined by a 48-h format. In summary, this novel DRCA is a useful means for serotyping of HSV in real time as well as a rapid screening method for determining anti-HSV susceptibilities. Copyright © 2011 Elsevier Inc. All rights reserved.

  13. In-vitro antimycobacterial drug susceptibility testing of non-tubercular mycobacteria by tetrazolium microplate assay.

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    Sankar, Manimuthu Mani; Gopinath, Krishnamoorthy; Singla, Roopak; Singh, Sarman

    2008-07-11

    Non-tubercular mycobacteria (NTM) has not been given due attention till the recent epidemic of HIV. This has led to increasing interest of health care workers in their biology, epidemiology and drug resistance. However, timely detection and drug susceptibility profiling of NTM isolates are always difficult in resource poor settings like India. Furthermore, no standardized methodology or guidelines are available to reproduce the results with clinical concordance. To find an alternative and rapid method for performing the drug susceptibility assay in a resource limited settings like India, we intended to evaluate the utility of Tetrazolium microplate assay (TEMA) in comparison with proportion method for reporting the drug resistance in clinical isolates of NTM. A total of fifty-five NTM isolates were tested for susceptibility against Streptomycin, Rifampicin, Ethambutol, Ciprofloxacin, Ofloxacin, Azithromycin, and Clarithromycin by TEMA and the results were compared with agar proportion method (APM). Of the 55 isolates, 23 (41.8%) were sensitive to all the drugs and the remaining 32 (58.2%) were resistant to at least one drug. TEMA had very good concordance with APM except with minor discrepancies. Susceptibility results were obtained in the median of 5 to 9 days by TEMA. The NTM isolates were highly sensitive against Ofloxacin (98.18% sensitive) and Ciprofloxacin (90.09% sensitive). M. mucogenicum was sensitive only to Clarithromycin and resistant to all the other drugs tested. The concordance between TEMA and APM ranged between 96.4 - 100%. Tetrazolium Microplate Assay is a rapid and highly reproducible method. However, it must be performed only in tertiary level Mycobacteriology laboratories with proper bio-safety conditions.

  14. A cell-based high-throughput screening assay for radiation susceptibility using automated cell counting

    International Nuclear Information System (INIS)

    Hodzic, Jasmina; Dingjan, Ilse; Maas, Mariëlle JP; Meulen-Muileman, Ida H van der; Menezes, Renee X de; Heukelom, Stan; Verheij, Marcel; Gerritsen, Winald R; Geldof, Albert A; Triest, Baukelien van; Beusechem, Victor W van

    2015-01-01

    Radiotherapy is one of the mainstays in the treatment for cancer, but its success can be limited due to inherent or acquired resistance. Mechanisms underlying radioresistance in various cancers are poorly understood and available radiosensitizers have shown only modest clinical benefit. There is thus a need to identify new targets and drugs for more effective sensitization of cancer cells to irradiation. Compound and RNA interference high-throughput screening technologies allow comprehensive enterprises to identify new agents and targets for radiosensitization. However, the gold standard assay to investigate radiosensitivity of cancer cells in vitro, the colony formation assay (CFA), is unsuitable for high-throughput screening. We developed a new high-throughput screening method for determining radiation susceptibility. Fast and uniform irradiation of batches up to 30 microplates was achieved using a Perspex container and a clinically employed linear accelerator. The readout was done by automated counting of fluorescently stained nuclei using the Acumen eX3 laser scanning cytometer. Assay performance was compared to that of the CFA and the CellTiter-Blue homogeneous uniform-well cell viability assay. The assay was validated in a whole-genome siRNA library screening setting using PC-3 prostate cancer cells. On 4 different cancer cell lines, the automated cell counting assay produced radiation dose response curves that followed a linear-quadratic equation and that exhibited a better correlation to the results of the CFA than did the cell viability assay. Moreover, the cell counting assay could be used to detect radiosensitization by silencing DNA-PKcs or by adding caffeine. In a high-throughput screening setting, using 4 Gy irradiated and control PC-3 cells, the effects of DNA-PKcs siRNA and non-targeting control siRNA could be clearly discriminated. We developed a simple assay for radiation susceptibility that can be used for high-throughput screening. This will aid

  15. Physician-initiated courtesy MODS testing for TB and MDR-TB diagnosis and patient management.

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    Nic Fhogartaigh, C J; Vargas-Prada, S; Huancaré, V; Lopez, S; Rodríguez, J; Moore, D A J

    2008-05-01

    Laboratorio de Investigación de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia (UPCH) and government health centres, Lima, Peru. To evaluate the contribution of unselected (courtesy) microscopic observation drug susceptibility (MODS) testing to the diagnosis and/or drug susceptibility testing (DST) of tuberculosis and their subsequent impact upon patient management. Retrospective database analysis and case note review of MODS culture-positive cases. Mycobacterium tuberculosis was isolated in 28.9% of 225 samples (209 patients); 22.2% of 63 positive cases were multidrug-resistant. In 58 MODS culture-positive cases with follow-up data available, MODS provided culture confirmation of diagnosis, DST or both in 82.8%, before any standard method. In 41.4%, this result should have prompted a modification in patient management. Delays between laboratory result and initiation or change of treatment, where applicable, took on average 42 and 64 days, respectively, of which a delay of respectively 17 and 48 days occurred after the receipt of results by the health facility. MODS provides important data for clinical management within a meaningful timeframe and should contribute positively to patient outcomes due to earlier initiation of appropriate therapy. Although clinicians may successfully select patients likely to benefit from MODS, ongoing work is required to identify optimal implementation of the assay and to reduce logistical and health system derived delays.

  16. Identification of Bacillus thuringiensis Cry1AbMod binding-proteins from Spodoptera frugiperda.

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    Martínez de Castro, Diana L; García-Gómez, Blanca I; Gómez, Isabel; Bravo, Alejandra; Soberón, Mario

    2017-12-01

    Bacillus thuringiensis Cry toxins are currently used for pest control in transgenic crops but evolution of resistance by the insect pests threatens the use of this technology. The Cry1AbMod toxin was engineered to lack the alpha helix-1 of the parental Cry1Ab toxin and was shown to counter resistance to Cry1Ab and Cry1Ac toxins in different insect species including the fall armyworm Spodoptera frugiperda. In addition, Cry1AbMod showed enhanced toxicity to Cry1Ab-susceptible S. frugiperda populations. To gain insights into the mechanisms of this Cry1AbMod-enhanced toxicity, we isolated the Cry1AbMod toxin binding proteins from S. frugiperda brush border membrane vesicles (BBMV), which were identified by pull-down assay and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The LC-MS/MS results indicated that Cry1AbMod toxin could bind to four classes of aminopeptidase (N1, N3, N4 y N5) and actin, with the highest amino acid sequence coverage acquired for APN 1 and APN4. In addition to these proteins, we found other proteins not previously described as Cry toxin binding proteins. This is the first report that suggests the interaction between Cry1AbMod and APN in S. frugiperda. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. In planta assay of hygromycin susceptibility and mutant screening in rice at heading stage

    International Nuclear Information System (INIS)

    Fu Haowei; Li Youfa; Ma Xinghua; Shen Shengquan; Shu Xiaoli; Shu Qingyao; Chen Yang

    2012-01-01

    Cells and tissue of plants carrying the hygromycin phosphotransferase gene (HPT) are tolerant to antibiotic hygromycin and hence become the common selection gene for genetic transformation of crop plants, particularly monocots. The present study aimed at establishing a rapid method for in planta screening of hygromycin tolerant plants in transgenic breeding. At heading stage transgenic and conventional rice plants were sprayed with hygromycin solutions of different concentrations (25 ∼ 100 mg/L) and toxic symptoms were observed in the following days. It was observed that yellow-brown necrotic spots appeared in the leaves and grains of conventional rice varieties after foliar spraying of 50 mg/L hygromycin, and the more spots were occurred with the higher hygromycin solution. There were 21.1 and 19.2 spots per cm 2 on flag leaves of indica varieties Jiayou 99 and C10, respectively; while 27.6% and 23.5% grains were yellow-brown in the varieties, respectively. The corresponding data for two japonica varieties Jiayou 5 and R5 were 11.8 and 10.7 for leave spots and 11.2% and 11.6% for yellow-brown grains, respectively. These results indicated that the two indica varieties are more sensitive to hygromycin than the two japonica varieties. In the treatment of hygromycin with above levels, the transgenic rice line KMD1 with the HPT gene showed no toxic symptoms on leaf or panicles. The γ-rays treated M 2 population of KMD1 was sprayed with 100 mg/L hygromycin solution at heading stage and 42 plants were screened out with toxic symptoms in leaves and panicles form 120000 plants. Among the 42 hygromycin susceptible plants, 14 plants with leaves available for in vitro feeding assay were subjected to the feeding of rice striped steam borers [Chilo supperssalis (Walker)] and all showed high resistance. The above results showed that spraying of 100 mg/L hygromycin solution at heading stage would lead to visually apparent toxic symptoms in susceptibility rice plants and hence

  18. A field evaluation of the Hardy TB MODS Kit™ for the rapid phenotypic diagnosis of tuberculosis and multi-drug resistant tuberculosis.

    Directory of Open Access Journals (Sweden)

    Laura Martin

    Full Text Available Even though the WHO-endorsed, non-commercial MODS assay offers rapid, reliable TB liquid culture and phenotypic drug susceptibility testing (DST at lower cost than any other diagnostic, uptake has been patchy. In part this reflects misperceptions about in-house assay quality assurance, but user convenience of one-stop procurement is also important. A commercial MODS kit was developed by Hardy Diagnostics (Santa Maria, CA, USA with PATH (Seattle, WA, USA to facilitate procurement, simplify procedures through readymade media, and enhance safety with a sealing silicone plate lid. Here we report the results from a large-scale field evaluation of the MODS kit in a government service laboratory.2446 sputum samples were cultured in parallel in Lowenstein-Jensen (LJ, conventional MODS and in the MODS kit. MODS kit DST was compared with conventional MODS (direct DST and proportion method (indirect DST. 778 samples (31.8% were Mycobacterium tuberculosis culture-positive. Compared to conventional MODS the sensitivity, specificity, positive, and negative predictive values (95% confidence intervals of the MODS Kit were 99.3% (98.3-99.8%, 98.3% (97.5-98.8%, 95.8% (94.0-97.1%, and 99.7% (99.3-99.9%. Median (interquartile ranges time to culture-positivity (and rifampicin and isoniazid DST was 10 (9-13 days for conventional MODS and 8.5 (7-11 for MODS Kit (p<0.01. Direct rifampicin and isoniazid DST in MODS kit was almost universally concordant with conventional MODS (97.9% agreement, 665/679 evaluable samples and reference indirect DST (97.9% agreement, 687/702 evaluable samples.MODS kit delivers performance indistinguishable from conventional MODS and offers a convenient, affordable alternative with enhanced safety from the sealing silicone lid. The availability in the marketplace of this platform, which conforms to European standards (CE-marked, readily repurposed for second-line DST in the near future, provides a fresh opportunity for improving equity of

  19. A rapid method for the determination of microbial susceptibility using the firefly luciferase assay for adenosine triphosphate (ATP)

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    Vellend, H.; Tuttle, S. A.; Barza, M.; Weinstein, L.; Picciolo, G. L.; Chappelle, E. W.

    1975-01-01

    Luciferase assay for adenosine triphosphate (ATP) was optimized for pure bacteria in broth in order to evaluate if changes in bacterial ATP content could be used as a rapid measure of antibiotic effect on microorganisms. Broth cultures of log phase bacteria were incubated at 310 K (37 C) for 2.5 hours at antimicrobial concentrations which resulted in the best discrimination between sensitive and resistant strains. Eighty-seven strains of 11 bacterial species were studied for their susceptibility to 12 commonly used antimicrobial agents: ampicillin, Penicillin G, nafcillin, carbenicillin, cephalothin, tetracycline, erythromycin, clindamycin, gentamicin, nitrofurantoin, colistin, and chloramplenicol. The major advantage of the ATP system over existing methods of rapid microbial susceptibility testing is that the assay can be made specific for bacterial ATP.

  20. Algebraic Structures on MOD Planes

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    Kandasamy, Vasantha; Ilanthenral, K.; Smarandache, Florentin

    2015-01-01

    Study of MOD planes happens to a very recent one. In this book, systematically algebraic structures on MOD planes like, MOD semigroups, MOD groups and MOD rings of different types are defined and studied. Such study is innovative for a large four quadrant planes are made into a small MOD planes. Several distinct features enjoyed by these MOD planes are defined, developed and described.

  1. Estimating Fitness by Competition Assays between Drug Susceptible and Resistant Mycobacterium tuberculosis of Predominant Lineages in Mumbai, India

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    Bhatter, Purva; Chatterjee, Anirvan; D'souza, Desiree; Tolani, Monica; Mistry, Nerges

    2012-01-01

    Background Multi Drug Resistant Tuberculosis (MDR TB) is a threat to global tuberculosis control. A significant fitness cost has been associated with DR strains from specific lineages. Evaluation of the influence of the competing drug susceptible strains on fitness of drug resistant strains may have an important bearing on understanding the spread of MDR TB. The aim of this study was to evaluate the fitness of MDR TB strains, from a TB endemic region of western India: Mumbai, belonging to 3 predominant lineages namely CAS, Beijing and MANU in the presence of drug susceptible strains from the same lineages. Methodology Drug susceptible strains from a single lineage were mixed with drug resistant strain, bearing particular non synonymous mutation (rpoB D516V; inhA, A16G; katG, S315T1/T2) from the same or different lineages. Fitness of M.tuberculosis (M.tb) strains was evaluated using the difference in growth rates obtained by using the CFU assay system. Conclusion/Significance While MANU were most fit amongst the drug susceptible strains of the 3 lineages, only Beijing MDR strains were found to grow in the presence of any of the competing drug susceptible strains. A disproportionate increase in Beijing MDR could be an alarm for an impending epidemic in this locale. In addition to particular non synonymous substitutions, the competing strains in an environment may impact the fitness of circulating drug resistant strains. PMID:22479407

  2. Mod i ledelse

    DEFF Research Database (Denmark)

    Mellon, Karsten

    2016-01-01

    Mod i ledelse er en efterspurgt vare i offentligt regi som modsvar på stigende kompleksitet og pres. Men hvad er ’mod i ledelse’ – og er du selv en modig leder?......Mod i ledelse er en efterspurgt vare i offentligt regi som modsvar på stigende kompleksitet og pres. Men hvad er ’mod i ledelse’ – og er du selv en modig leder?...

  3. Evaluation of MODS Culture in the Diagnosis of Pulmonary Tuberculosis

    Directory of Open Access Journals (Sweden)

    Z Aminzadeh

    2012-05-01

    Full Text Available

    Background and Objectives

    Culture of M. tuberculosis is the golden standard for the diagnosis of TB which is a much more sensitive test than Smear examination. There is a strong need to use the new assays in order to speed up diagnostic methods. The aim of this research was to determine the evaluation of Microscopic Observation Drug Susceptibility culture in pulmonary tuberculosis in comparison with Ziehl-Neelsen stain and Lowenstein-Jensen culture of sputum.

     

    Methods

    The research method was a Cross-sectional (diagnostic test and the technique was observational-interview type. If the patient's history revealed clinical criteria compatible with TB and the infectious specialist’s judgment was that of "TB suspected case, the patient was considered a pulmonary TB suspect. Then, in addition to sputum Ziehl-Neelsen stain and culture for Lowenstein-Jensen, we carried out MODS culture as well.

     

    Results

    100 patients (48 male, 52 female with mean age of 52.9 ± 21.83 were evaluated. During sputum examination, 40% were Ziehl-Neelsen stain positive while 30% had positive sputum culture for Mycobacterium Tuberculosis in Lowenstein-Jensen and 47% had positive MODS culture. In comparison with sputum smear and Lowenstein-Jensen culture, MODS had a sensitivity of 82.5% and 86%, specificity of 77% and 70%, positive predictive value of 70% and 55%, negative predictive value of 86% and 92%, respectively.

     

    Conclusion

    MODS culture demonstrated faster recovery and higher negative predictive value than by Lowenstein-Jensen method; it could be a simple and rapid method in the diagnosis of pulmonary tuberculosis.

  4. Morphological characterization of Mycobacterium tuberculosis in a MODS culture for an automatic diagnostics through pattern recognition.

    Directory of Open Access Journals (Sweden)

    Alicia Alva

    Full Text Available Tuberculosis control efforts are hampered by a mismatch in diagnostic technology: modern optimal diagnostic tests are least available in poor areas where they are needed most. Lack of adequate early diagnostics and MDR detection is a critical problem in control efforts. The Microscopic Observation Drug Susceptibility (MODS assay uses visual recognition of cording patterns from Mycobacterium tuberculosis (MTB to diagnose tuberculosis infection and drug susceptibility directly from a sputum sample in 7-10 days with a low cost. An important limitation that laboratories in the developing world face in MODS implementation is the presence of permanent technical staff with expertise in reading MODS. We developed a pattern recognition algorithm to automatically interpret MODS results from digital images. The algorithm using image processing, feature extraction and pattern recognition determined geometrical and illumination features used in an object-model and a photo-model to classify TB-positive images. 765 MODS digital photos were processed. The single-object model identified MTB (96.9% sensitivity and 96.3% specificity and was able to discriminate non-tuberculous mycobacteria with a high specificity (97.1% M. avium, 99.1% M. chelonae, and 93.8% M. kansasii. The photo model identified TB-positive samples with 99.1% sensitivity and 99.7% specificity. This algorithm is a valuable tool that will enable automatic remote diagnosis using Internet or cellphone telephony. The use of this algorithm and its further implementation in a telediagnostics platform will contribute to both faster TB detection and MDR TB determination leading to an earlier initiation of appropriate treatment.

  5. Who owns the mods?

    OpenAIRE

    Kow, Yong Ming; Nardi, Bonnie

    2010-01-01

    Modding, the development of end user software extensions to commercial products, is popular among video gamers. Modders form communities to help each other. Mods can shape software products by weaving in contributions from users themselves based on their own experience of a product. The purpose of this paper is to investigate a conflict between a modding community and a gaming company which reveals contested issues of ownership and governance. We studied an online game, World of Warcraft, a l...

  6. Effects of agricultural fungicides on microorganisms associated with floral nectar: susceptibility assays and field experiments.

    Science.gov (United States)

    Bartlewicz, Jacek; Pozo, María I; Honnay, Olivier; Lievens, Bart; Jacquemyn, Hans

    2016-10-01

    Pesticides have become an inseparable element of agricultural intensification. While the direct impact of pesticides on non-target organisms, such as pollinators, has recently received much attention, less consideration has been given to the microorganisms that are associated with them. Specialist yeasts and bacteria are known to commonly inhabit floral nectar and change its chemical characteristics in numerous ways, possibly influencing pollinator attraction. In this study, we investigated the in vitro susceptibility of nectar yeasts Metschnikowia gruessi, Metschnikowia reukaufii, and Candida bombi to six widely used agricultural fungicides (prothioconazole, tebuconazole, azoxystrobin, fenamidone, boscalid, and fluopyram). Next, a commercial antifungal mixture containing tebuconazole and trifloxystrobin was applied to natural populations of the plant Linaria vulgaris and the occurrence, abundance, and diversity of nectar-inhabiting yeasts and bacteria was compared between treated and untreated plants. The results showed that prothioconazole and tebuconazole were highly toxic to nectar yeasts, inhibiting their growth at concentrations varying between 0.06 and 0.5 mg/L. Azoxystrobin, fenamidone, boscalid, and fluopyram on the other hand exhibited considerably lower toxicity, inhibiting yeast growth at concentrations between 1 and 32 mg/L or in many cases not inhibiting microbial growth at all. The application of the antifungal mixture in natural plant populations resulted in a significant decrease in the occurrence and abundance of yeasts in individual flowers, but this did not translate into noticeable changes in bacterial incidence and abundance. Yeast and bacterial species richness and distribution did not also differ between treated and untreated plants. We conclude that the application of fungicides may have negative effects on the abundance of nectar yeasts in floral nectar. The consequences of these effects on plant pollination processes in agricultural

  7. Rapid, low-cost fluorescent assay of β-lactamase-derived antibiotic resistance and related antibiotic susceptibility

    Science.gov (United States)

    Erdem, S. Sibel; Khan, Shazia; Palanisami, Akilan; Hasan, Tayyaba

    2014-10-01

    Antibiotic resistance (AR) is increasingly prevalent in low and middle income countries (LMICs), but the extent of the problem is poorly understood. This lack of knowledge is a critical deficiency, leaving local health authorities essentially blind to AR outbreaks and crippling their ability to provide effective treatment guidelines. The crux of the problem is the lack of microbiology laboratory capacity available in LMICs. To address this unmet need, we demonstrate a rapid and simple test of β-lactamase resistance (the most common form of AR) that uses a modified β-lactam structure decorated with two fluorophores quenched due to their close proximity. When the β-lactam core is cleaved by β-lactamase, the fluorophores dequench, allowing assay speeds of 20 min to be obtained with a simple, streamlined protocol. Furthermore, by testing in competition with antibiotics, the β-lactamase-associated antibiotic susceptibility can also be extracted. This assay can be easily implemented into standard lab work flows to provide near real-time information of β-lactamase resistance, both for epidemiological purposes as well as individualized patient care.

  8. The detection and differentiation of methicillin-resistant and methicillin-susceptible Staphylococcus aureus endocarditis by using the BD GeneOhm StaphSR Assay.

    Science.gov (United States)

    Frey, Amy B; Wilson, Deborah A; LaSalvia, Margaret M; Tan, Carmela D; Rodriguez, E Rene; Shrestha, Nabin K; Hall, Gerri S; Procop, Gary W

    2011-11-01

    We use the BD GeneOhm StaphSR Assay (BD Diagnostics, Oakville, Canada) to screen for Staphylococcus aureus nasal colonization and sought to evaluate this assay for the assessment of valve specimens from patients with endocarditis. We examined 23 paired fresh and formalin-fixed, paraffin-embedded cardiac valve tissue samples, 12 of which had S aureus endocarditis, using the BD GeneOhm StaphSR Assay for the detection and differentiation of methicillin-susceptible and methicillin-resistant S aureus. This assay appropriately characterized all specimens with respect to the presence or absence of S aureus. There was an 87.5% correlation between the presence or absence of the mecA gene and the oxacillin susceptibility results for the S aureus isolates studied. The GeneOhm StaphSR assay accurately detected S aureus in cardiac valve tissue samples. Rare discordances were observed between oxacillin susceptibility status and mecA gene detection by this assay.

  9. Evaluation of the MODS culture technique for the diagnosis of tuberculous meningitis.

    Directory of Open Access Journals (Sweden)

    Maxine Caws

    2007-11-01

    Full Text Available Tuberculous meningitis (TBM is a devastating condition. The rapid instigation of appropraite chemotherapy is vital to reduce morbidity and mortality. However rapid diagnosis remains elusive; smear microscopy has extremely low sensitivity on cerebrospinal fluid (CSF in most laboratories and PCR requires expertise with advanced infrastructure and has sensitivity of only around 60% under optimal conditions. Neither technique allows for the microbiological isolation of M. tuberculosis and subsequent drug susceptibility testing. We evaluated the recently developed microscopic observation drug susceptibility (MODS assay format for speed and accuracy in diagnosing TBM.Two hundred and thirty consecutive CSF samples collected from 156 patients clinically suspected of TBM on presentation at a tertiary referal hospital in Vietnam were enrolled into the study over a five month period and tested by Ziehl-Neelsen (ZN smear, MODS, Mycobacterial growth Indicator tube (MGIT and Lowenstein-Jensen (LJ culture. Sixty-one samples were from patients already on TB therapy for >1day and 19 samples were excluded due to untraceable patient records. One hundred and fifty samples from 137 newly presenting patients remained. Forty-two percent (n = 57/137 of patients were deemed to have TBM by clinical diagnostic and microbiological criteria (excluding MODS. Sensitivity by patient against clinical gold standard for ZN smear, MODS MGIT and LJ were 52.6%, 64.9%, 70.2% and 70.2%, respectively. Specificity of all microbiological techniques was 100%. Positive and negative predictive values for MODS were 100% and 78.7%, respectively for HIV infected patients and 100% and 82.1% for HIV negative patients. The median time to positive was 6 days (interquartile range 5-7, significantly faster than MGIT at 15.5 days (interquartile range 12-24, and LJ at 24 days (interquartile range 18-35 days (P<0.01.We have shown MODS to be a sensitive, rapid technique for the diagnosis of TBM with

  10. Analyzing pepsin degradation assay conditions used for allergenicity assessments to ensure that pepsin susceptible and pepsin resistant dietary proteins are distinguishable.

    Directory of Open Access Journals (Sweden)

    Rong Wang

    Full Text Available The susceptibility of a dietary protein to proteolytic degradation by digestive enzymes, such as gastric pepsin, provides information on the likelihood of systemic exposure to a structurally intact and biologically active macromolecule, thus informing on the safety of proteins for human and animal consumption. Therefore, the purpose of standardized in vitro degradation studies that are performed during protein safety assessments is to distinguish whether proteins of interest are susceptible or resistant to pepsin degradation via a study design that enables study-to-study comparison. Attempting to assess pepsin degradation under a wide-range of possible physiological conditions poses a problem because of the lack of robust and consistent data collected under a large-range of sub-optimal conditions, which undermines the needs to harmonize in vitro degradation conditions. This report systematically compares the effects of pH, incubation time, and pepsin-to-substrate protein ratio on the relative degradation of five dietary proteins: three pepsin susceptible proteins [ribulose 1,5-bisphosphate carboxylase-oxygenase (Rubisco, horseradish peroxidase (HRP, hemoglobin (Hb], and two pepsin resistant proteins [lipid transfer protein (LTP and soybean trypsin inhibitor (STI]. The results indicate that proteins susceptible to pepsin degradation are readily distinguishable from pepsin-resistant proteins when the reaction conditions are within the well-characterized optima for pepsin. The current standardized in vitro pepsin resistant assay with low pH and high pepsin-to-substrate ratio fits this purpose. Using non-optimal pH and/or pepsin-to-substrate protein ratios resulted in susceptible proteins no longer being reliably degraded by this stomach enzyme, which compromises the ability of this in vitro assay to distinguish between resistant and susceptible proteins and, therefore, no longer providing useful data to an overall weight-of-evidence approach to

  11. Alcator C-Mod Tokamak

    Data.gov (United States)

    Federal Laboratory Consortium — Alcator C-Mod at the Massachusetts Institute of Technology is operated as a DOE national user facility. Alcator C-Mod is a unique, compact tokamak facility that uses...

  12. NAUA Mod 4

    International Nuclear Information System (INIS)

    Bunz, H.; Koyro, M.; Schoeck, W.

    1983-08-01

    This report describes the computer program NAUA Mod4. Its purpose is to calculate the behaviour of a polydisperse aerosol system in a closed vessel containing a condensing atmosphere as a function of the time. The main object is to explain the physical background and to describe the structure of the code and the input and output in detail. (orig.) [de

  13. Teaching Mods with Class

    DEFF Research Database (Denmark)

    Champion, Erik

    2012-01-01

    from around the world, representing fields as diverse as architecture, ethnography, puppetry, cultural studies, music education, interaction design and industrial design. How can we design, play with and reflect on the contribution of game mods, related tools and techniques, to both game studies...

  14. A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

    LENUS (Irish Health Repository)

    Song, Yajun

    2010-08-01

    OBJECTIVES: Decreased susceptibility to fluoroquinolones has become a major problem for the successful therapy of human infections caused by Salmonella enterica, especially the life-threatening typhoid and paratyphoid fevers. METHODS: By using Luminex xTAG beads, we developed a rapid, reliable and cost-effective multiplexed genotyping assay for simultaneously detecting 11 mutations in gyrA, gyrB and parE of S. enterica serovars Typhi and Paratyphi A that result in nalidixic acid resistance (Nal(R)) and\\/or decreased susceptibility to fluoroquinolones. RESULTS: This assay yielded unambiguous single nucleotide polymorphism calls on extracted DNA from 292 isolates of Salmonella Typhi (Nal(R) = 223 and Nal(S) = 69) and 106 isolates of Salmonella Paratyphi A (Nal(R) = 24 and Nal(S) = 82). All of the 247 Nal(R) Salmonella Typhi and Salmonella Paratyphi A isolates were found to harbour at least one of the target mutations, with GyrA Phe-83 as the most common one (143\\/223 for Salmonella Typhi and 18\\/24 for Salmonella Paratyphi A). We also identified three GyrB mutations in eight Nal(S) Salmonella Typhi isolates (six for GyrB Phe-464, one for GyrB Leu-465 and one for GyrB Asp-466), and mutations GyrB Phe-464 and GyrB Asp-466 seem to be related to the decreased ciprofloxacin susceptibility phenotype in Salmonella Typhi. This assay can also be used directly on boiled single colonies. CONCLUSIONS: The assay presented here would be useful for clinical and reference laboratories to rapidly screen quinolone-resistant isolates of Salmonella Typhi and Salmonella Paratyphi A, and decipher the underlying genetic changes for epidemiological purposes.

  15. Implementación de un sistema de telediagnóstico de tuberculosis y determinación de multidrogorresistencia basada en el método Mods en Trujillo, Perú

    Directory of Open Access Journals (Sweden)

    Luis Rodríguez

    Full Text Available Objetivos. Implementar un sistema para el diagnóstico remoto de tuberculosis y multidrogorresistencia (MDR usando el método Microscopic-Observation Drug Susceptibility Assay (MODS en el Laboratorio de Micobacterias del Centro de Excelencia en Tuberculosis de Trujillo (CENEX-Trujillo. El sistema incluyó una variante de un algoritmo de reconocimiento de Mycobacterium tuberculosis recientemente reportado a partir de imágenes digitales de cultivos MODS de muestras de esputo. Materiales y métodos. Se optimizó un algoritmo de reconocimiento por medio de un reentrenamiento del modelo estadístico basado en imágenes digitales de cultivos MODS provenientes del Laboratorio de Micobacterias del CENEX-Trujillo. Se obtuvieron imágenes de 50 cultivos MODS positivos de pacientes con sospecha de tuberculosis multidrogorresistente entre enero y octubre de 2012 en el CENEX-Trujillo. Resultados. La sensibilidad y la especificidad en objetos, para reconocer cordones de tuberculosis fueron de 92,04% y de 94,93% respectivamente. La sensibilidad y la especificidad en foto, para determinar un campo positivo a tuberculoisis fueron 95,4% y de 98,07% respectivamente. Conclusiones. Los resultados demostraron la factibilidad de la implementación de telediagnóstico en lugares remotos, el cual puede contribuir con la detección temprana de tuberculosis multidrogorresistente mediante el método MODS

  16. Evaluation of GenoType® MTBDRplus assay for rapid detection of drug susceptibility testing of multi-drug resistance tuberculosis in Northern India

    Directory of Open Access Journals (Sweden)

    Anand Kumar Maurya

    2013-01-01

    Full Text Available Background: The problem of multi-drug resistance tuberculosis (MDR-TB is growing in several hotspots throughout the world. Rapid and accurate diagnosis of MDR-TB is crucial to facilitate early treatment and to reduce its spread in the community. The aim of the present study was to evaluate the new, novel GenoType® MTBDRplus assay for rapid detection of drug susceptibility testing (DST of MDR-TB cases in Northern India. Materials and Methods: A total of 550 specimens were collected from highly suspected drug resistant from pulmonary and extra-pulmonary TB cases. All the specimens were processed by Ziehl- Neelsen staining, culture, differentiation by the GenoType® CM assay, first line DST using BacT/ALERT 3D system and GenoType® MTBDRplus assay. The concordance of the GenoType® MTBDRplus assay was calculated in comparison with conventional DST results. Results: Overall the sensitivity for detection of rifampicin, isoniazid and MDR-TB resistance by GenoType® MTBDRplus assay was 98.0%, 98.4% and 98.2% respectively. Out of 55 MDR-TB strains, 45 (81.8%, 52 (94.5% and 17 (30.9% strains showed mutation in rpoB, katG and inhA genes respectively (P < 0.05. The most prominent mutations in rpoB, katG and inhA genes were; 37 (67.3% in S531L, 52 (94.5% in S315T1 and 11 (20% in C15T regions respectively (P < 0.05. Conclusions: Our study demonstrated a high concordance between the GenoType® MTBDRplus assay resistance patterns and those were observed by conventional DST with good sensitivity, specificity with short turnaround times and to control new cases of MDR-TB in countries with a high prevalence of MDR-TB.

  17. A new rapid colourimetric method for testing Mycobacterium tuberculosis susceptibility to isoniazid and rifampicin: a crystal violet decolourisation assay

    Directory of Open Access Journals (Sweden)

    Ahmet Yilmaz Coban

    2014-04-01

    Full Text Available The aim of this study was to investigate the performance of a new and accurate method for the detection of isoniazid (INH and rifampicin (RIF resistance among Mycobacterium tuberculosis isolates using a crystal violet decolourisation assay (CVDA. Fifty-five M. tuberculosis isolates obtained from culture stocks stored at -80ºC were tested. After bacterial inoculation, the samples were incubated at 37ºC for seven days and 100 µL of CV (25 mg/L stock solution was then added to the control and sample tubes. The tubes were incubated for an additional 24-48 h. CV (blue/purple was decolourised in the presence of bacterial growth; thus, if CV lost its colour in a sample containing a drug, the tested isolate was reported as resistant. The sensitivity, specificity, positive predictive value, negative predictive value and agreement for INH were 92.5%, 96.4%, 96.1%, 93.1% and 94.5%, respectively, and 88.8%, 100%, 100%, 94.8% and 96.3%, respectively, for RIF. The results were obtained within eight-nine days. This study shows that CVDA is an effective method to detect M. tuberculosis resistance to INH and RIF in developing countries. This method is rapid, simple and inexpensive. Nonetheless, further studies are necessary before routine laboratory implementation.

  18. Properties of the periplasmic ModA molybdate-binding protein of Escherichia coli.

    Science.gov (United States)

    Rech, S; Wolin, C; Gunsalus, R P

    1996-02-02

    The modABCD operon, located at 17 min on the Escherichia coli chromosome, encodes the protein components of a high affinity molybdate uptake system. Sequence analysis of the modA gene (GenBank L34009) predicts that it encodes a periplasmic binding protein based on the presence of a leader-like sequence at its N terminus. To examine the properties of the ModA protein, the modA structural gene was overexpressed, and its product was purified. The ModA protein was localized to the periplasmic space of the cell, and it was released following a gentle osmotic shock. The N-terminal sequence of ModA confirmed that a leader region of 24 amino acids was removed upon export from the cell. The apparent size of ModA is 31.6 kDa as determined by gel sieve chromatography, whereas it is 22.5 kDa when examined by SDS-polyacrylamide gel electrophoresis. A ligand-dependent protein mobility shift assay was devised using a native polyacrylamide gel electrophoresis protocol to examine binding of molybdate and other anions to the ModA periplasmic protein. Whereas molybdate and tungstate were bound with high affinity (approximately 5 microM), sulfate, chromate, selenate, phosphate, and chlorate did not bind even when tested at 2 mM. A UV spectral assay revealed apparent Kd values of binding for molybdate and tungstate of 3 and 7 microM, respectively. Strains defective in the modA gene were unable to transport molybdate unless high levels of the anion were supplied in the medium. Therefore the modA gene product is essential for high affinity molybdate uptake by the cell. Tungstate interference of molybdate acquisition by the cell is apparently due in part to the high affinity of the ModA protein for this anion.

  19. Diagnostic multiplex polymerase chain reaction assay for the identification of Pseudomonas aeruginosa from the skin biopsy specimens in burn wound infections and detection of antibiotic susceptibility

    International Nuclear Information System (INIS)

    Mashouf, Rasoul Y.; Farahani, Hadi S.; Zamani, A.

    2008-01-01

    Objective was to identify Pseudomonas aeruginosa (P. aeruginosa) from the skin biopsy specimens in burn wound infections by multiplex polymerase chain reaction (M-PCR) and detection of antimicrobial susceptibility of isolates from culture. We conducted the cross-sectional study in 140 patients with wound infections who admitted to referral burn center of Motahari, Tehran, Iran, during a 12-month period from 2005-2006. Skin biopsy specimens were aseptically taken from each patient, one for PCR and one for bacterial culture. A M-PCR test based on simultaneous amplification of 2 lipoprotein genes: oprI and oprL, was used to directly detect fluorescent pseudomonades and P. aeruginosa in skin biopsy specimens. The susceptibility of P. aeruginosa isolates to 16 antibiotics was determined using the disc diffusion method. Out of 140 biopsy specimens, M-PCR detected 66 (47.2%) isolates, while culture detected 57 (40.7%) isolates as P. aeruginosa. Positive results for both genes which observed only for P. aeruginosa, while only one gene, oprI, was amplified from other fluorescent pseudomonades (n=12) and all other bacterial tested (n=62) were negative by the amplification test. The most effective antibiotics against isolate of P. aeruginosa were cefepime (79%), azetreonam (76%), ticarcillin-clavulanic acid (68%), tobramycin (62%) and amikacin (61%). Multiplex PCR assay appears promising for the rapid and sensitive detection of P. aeruginosa from the burned skin biopsy specimens. Simultaneous amplification of 2 lipoprotein genes: oprI and oprL could detect P. aeruginosa and oprI gene only for other fluorescent pseudomonades. (author)

  20. Expression, purification and DNA-binding activities of two putative ModE proteins of Herbaspirillum seropedicae (Burkholderiales, Oxalobacteraceae

    Directory of Open Access Journals (Sweden)

    André L.F. Souza

    2008-01-01

    Full Text Available In prokaryotes molybdenum is taken up by a high-affinity ABC-type transporter system encoded by the modABC genes. The endophyte β-Proteobacterium Herbaspirillum seropedicae has two modABC gene clusters and two genes encoding putative Mo-dependent regulator proteins (ModE1 and ModE2. Analysis of the amino acid sequence of the ModE1 protein of H. seropedicae revealed the presence of an N-terminal domain containing a DNA-binding helix-turn-helix motif (HTH and a C-terminal domain with a molybdate-binding motif. The second putative regulator protein, ModE2, contains only the helix-turn-helix motif, similar to that observed in some sequenced genomes. We cloned the modE1 (810 bp and modE2 (372 bp genes and expressed them in Escherichia coli as His-tagged fusion proteins, which we subsequently purified. The over-expressed recombinant His-ModE1 was insoluble and was purified after solubilization with urea and then on-column refolded during affinity chromatography. The His-ModE2 was expressed as a soluble protein and purified by affinity chromatography. These purified proteins were analyzed by DNA band-shift assays using the modA2 promoter region as probe. Our results indicate that His-ModE1 and His-ModE2 are able to bind to the modA2 promoter region, suggesting that both proteins may play a role in the regulation of molybdenum uptake and metabolism in H. seropedicae.

  1. Rapid identification and susceptibility testing of uropathogenic microbes via immunosorbent ATP-bioluminescence assay on a microfluidic simulator for antibiotic therapy.

    Science.gov (United States)

    Dong, Tao; Zhao, Xinyan

    2015-02-17

    The incorporation of pathogen identification with antimicrobial susceptibility testing (AST) was implemented on a concept microfluidic simulator, which is well suited for personalizing antibiotic treatment of urinary tract infections (UTIs). The microfluidic device employs a fiberglass membrane sandwiched between two polypropylene components, with capture antibodies immobilized on the membrane. The chambers in the microfluidic device share the same geometric distribution as the wells in a standard 384-well microplate, resulting in compatibility with common microplate readers. Thirteen types of common uropathogenic microbes were selected as the analytes in this study. The microbes can be specifically captured by various capture antibodies and then quantified via an ATP bioluminescence assay (ATP-BLA) either directly or after a variety of follow-up tests, including urine culture, antibiotic treatment, and personalized antibiotic therapy simulation. Owing to the design of the microfluidic device, as well as the antibody specificity and the ATP-BLA sensitivity, the simulator was proven to be able to identify UTI pathogen species in artificial urine samples within 20 min and to reliably and simultaneously verify the antiseptic effects of eight antibiotic drugs within 3-6 h. The measurement range of the device spreads from 1 × 10(3) to 1 × 10(5) cells/mL in urine samples. We envision that the medical simulator might be broadly employed in UTI treatment and could serve as a model for the diagnosis and treatment of other diseases.

  2. MOD silver metallization for photovoltaics

    Science.gov (United States)

    Vest, G. M.; Vest, R. W.

    1984-01-01

    The development of flat plate solar arrays is reported. Photovoltaic cells require back side metallization and a collector grid system on the front surface. Metallo-organic decomposition (MOD) silver films can eliminate most of the present problems with silver conductors. The objectives are to: (1) identify and characterize suitable MO compounds; (2) develop generic synthesis procedures for the MO compounds; (3) develop generic fabrication procedures to screen printable MOD silver inks; (4) optimize processing conditions to produce grid patterns and photovoltaic cells; and (5) develop a model which describes the adhesion between the fired silver film and the silicon surface.

  3. Extension of the lod score: the mod score.

    Science.gov (United States)

    Clerget-Darpoux, F

    2001-01-01

    In 1955 Morton proposed the lod score method both for testing linkage between loci and for estimating the recombination fraction between them. If a disease is controlled by a gene at one of these loci, the lod score computation requires the prior specification of an underlying model that assigns the probabilities of genotypes from the observed phenotypes. To address the case of linkage studies for diseases with unknown mode of inheritance, we suggested (Clerget-Darpoux et al., 1986) extending the lod score function to a so-called mod score function. In this function, the variables are both the recombination fraction and the disease model parameters. Maximizing the mod score function over all these parameters amounts to maximizing the probability of marker data conditional on the disease status. Under the absence of linkage, the mod score conforms to a chi-square distribution, with extra degrees of freedom in comparison to the lod score function (MacLean et al., 1993). The mod score is asymptotically maximum for the true disease model (Clerget-Darpoux and Bonaïti-Pellié, 1992; Hodge and Elston, 1994). Consequently, the power to detect linkage through mod score will be highest when the space of models where the maximization is performed includes the true model. On the other hand, one must avoid overparametrization of the model space. For example, when the approach is applied to affected sibpairs, only two constrained disease model parameters should be used (Knapp et al., 1994) for the mod score maximization. It is also important to emphasize the existence of a strong correlation between the disease gene location and the disease model. Consequently, there is poor resolution of the location of the susceptibility locus when the disease model at this locus is unknown. Of course, this is true regardless of the statistics used. The mod score may also be applied in a candidate gene strategy to model the potential effect of this gene in the disease. Since, however, it

  4. ModA and ModB, two ADP-ribosyltransferases encoded by bacteriophage T4: catalytic properties and mutation analysis.

    Science.gov (United States)

    Tiemann, Bernd; Depping, Reinhard; Gineikiene, Egle; Kaliniene, Laura; Nivinskas, Rimas; Rüger, Wolfgang

    2004-11-01

    Bacteriophage T4 encodes three ADP-ribosyltransferases, Alt, ModA, and ModB. These enzymes participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. In order to obtain a better understanding of the phage-host interactions and their consequences for regulating the T4 replication cycle, we studied cloning, overexpression, and characterization of purified ModA and ModB enzymes. Site-directed mutagenesis confirmed that amino acids, as deduced from secondary structure alignments, are indeed decisive for the activity of the enzymes, implying that the transfer reaction follows the Sn1-type reaction scheme proposed for this class of enzymes. In vitro transcription assays performed with Alt- and ModA-modified RNA polymerases demonstrated that the Alt-ribosylated polymerase enhances transcription from T4 early promoters on a T4 DNA template, whereas the transcriptional activity of ModA-modified polymerase, without the participation of T4-encoded auxiliary proteins for middle mode or late transcription, is reduced. The results presented here support the conclusion that ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control. In contrast, subsequent modification of the other cellular target proteins limits transcription from phage early genes and participates in redirecting transcription to phage middle and late genes.

  5. Obamas Fortsatte Krig mod Terror

    DEFF Research Database (Denmark)

    Ulrich, Philip Christian

    2013-01-01

    Kronikken argumenterer for at den type overvågningsskandaler som er fulgt i kølvandet på Edward Snowdens afsløringer blot er et symptom på den nye fase af krigen mod terror som Obama administrationen har ønsket at føre USA ind i. Den nye fase vil være præget af mere efterretningsvirksomhed snarere...

  6. The Escherichia coli modE gene: effect of modE mutations on molybdate dependent modA expression.

    Science.gov (United States)

    McNicholas, P M; Chiang, R C; Gunsalus, R P

    1996-11-15

    The Escherichia coli modABCD operon, which encodes a high-affinity molybdate uptake system, is transcriptionally regulated in response to molybdate availability by ModE. Here we describe a highly effective enrichment protocol, applicable to any gene with a repressor role, and establish its application in the isolation of transposon mutations in modE. In addition we show that disruption of the ModE C-terminus abolishes derepression in the absence of molybdate, implying this region of ModE controls the repressor activity. Finally, a mutational analysis of a proposed molybdate binding motif indicates that this motif does not function in regulating the repressor activity of ModE.

  7. TC-13 Mod 0 and Mod 2 Steam Catapult Test Site

    Data.gov (United States)

    Federal Laboratory Consortium — Located on 11,000 feet of test runway, the TC-13 Mod 0 and Mod 2 Steam Catapult Test Site has in-ground catapults identical to those aboard carriers. This test site...

  8. RELAP5/MOD2 development

    International Nuclear Information System (INIS)

    Miller, C.S.

    1986-01-01

    Status of the RELAP5/MOD2 computer code is discussed. While the code is undergoing international assessment, emphasis is on user support and code maintenance with modifications allowed only for error correction and user convenience improvements. User support discussed is the response to user inquiries, maintenance of manuals and the implementation of a PC based newletter service. The major 1986 user convenience improvement is the self-initialization option. The method is discussed and examples for PWR ''U tube'' and ''once through'' plants are illustrated. Future plans are also outlined

  9. RELAP5/MOD2 development

    International Nuclear Information System (INIS)

    Miller, C.S.

    1987-01-01

    Status of the RELAP5/MOD2 computer code is discussed. While the code is undergoing international assessment, emphasis is on user support and code maintenance with modifications allowed only for error correction and user convenience improvements. User support discussed is the response to user inquiries, maintenance of manuals and the implementation of a PC based newsletter service. The major 1986 user convenience improvement is the self-initialization option. The method is discussed and examples for PWR U tube and once through plants are illustrated. Future plans are also outlined

  10. Mod two homology and cohomology

    CERN Document Server

    Hausmann, Jean-Claude

    2014-01-01

    Cohomology and homology modulo 2 helps the reader grasp more readily the basics of a major tool in algebraic topology. Compared to a more general approach to (co)homology this refreshing approach has many pedagogical advantages: It leads more quickly to the essentials of the subject, An absence of signs and orientation considerations simplifies the theory, Computations and advanced applications can be presented at an earlier stage, Simple geometrical interpretations of (co)chains. Mod 2 (co)homology was developed in the first quarter of the twentieth century as an alternative to integral homology, before both became particular cases of (co)homology with arbitrary coefficients. The first chapters of this book may serve as a basis for a graduate-level introductory course to (co)homology. Simplicial and singular mod 2 (co)homology are introduced, with their products and Steenrod squares, as well as equivariant cohomology. Classical applications include Brouwer's fixed point theorem, Poincaré duality, Borsuk-Ula...

  11. On mod 2 and higher elliptic genera

    International Nuclear Information System (INIS)

    Liu Kefeng

    1992-01-01

    In the first part of this paper, we construct mod 2 elliptic genera on manifolds of dimensions 8k+1, 8k+2 by mod 2 index formulas of Dirac operators. They are given by mod 2 modular forms or mod 2 automorphic functions. We also obtain an integral formula for the mod 2 index of the Dirac operator. As a by-product we find topological obstructions to group actions. In the second part, we construct higher elliptic genera and prove some of their rigidity properties under group actions. In the third part we write down characteristic series for all Witten genera by Jacobi theta-functions. The modular property and transformation formulas of elliptic genera then follow easily. We shall also prove that Krichever's genera, which come from integrable systems, can be written as indices of twisted Dirac operators for SU-manifolds. Some general discussions about elliptic genera are given. (orig.)

  12. Molybdate transporter ModABC is important for Pseudomonas aeruginosa chronic lung infection.

    Science.gov (United States)

    Périnet, Simone; Jeukens, Julie; Kukavica-Ibrulj, Irena; Ouellet, Myriam M; Charette, Steve J; Levesque, Roger C

    2016-01-12

    Mechanisms underlying the success of Pseudomonas aeruginosa in chronic lung infection among cystic fibrosis (CF) patients are poorly defined. The modA gene was previously linked to in vivo competitiveness of P. aeruginosa by a genetic screening in the rat lung. This gene encodes a subunit of transporter ModABC, which is responsible for extracellular uptake of molybdate. This compound is essential for molybdoenzymes, including nitrate reductases. Since anaerobic growth conditions are known to occur during CF chronic lung infection, inactivation of a molybdate transporter could inhibit proliferation through the inactivation of denitrification enzymes. Hence, we performed phenotypic characterization of a modA mutant strain obtained by signature-tagged mutagenesis (STM_modA) and assessed its virulence in vivo with two host models. The STM_modA mutant was in fact defective for anaerobic growth and unable to use nitrates in the growth medium for anaerobic respiration. Bacterial growth and nitrate usage were restored when the medium was supplemented with molybdate. Most significantly, the mutant strain showed reduced virulence compared to wild-type strain PAO1 according to a competitive index in the rat model of chronic lung infection and a predation assay with Dictyostelium discoideum amoebae. As the latter took place in aerobic conditions, the in vivo impact of the mutation in modA appears to extend beyond its effect on anaerobic growth. These results support the modABC-encoded transporter as important for the pathogenesis of P. aeruginosa, and suggest that enzymatic machinery implicated in anaerobic growth during chronic lung infection in CF merits further investigation as a potential target for therapeutic intervention.

  13. An Optimization Scheme for ProdMod

    International Nuclear Information System (INIS)

    Gregory, M.V.

    1999-01-01

    A general purpose dynamic optimization scheme has been devised in conjunction with the ProdMod simulator. The optimization scheme is suitable for the Savannah River Site (SRS) High Level Waste (HLW) complex operations, and able to handle different types of optimizations such as linear, nonlinear, etc. The optimization is performed in the stand-alone FORTRAN based optimization deliver, while the optimizer is interfaced with the ProdMod simulator for flow of information between the two

  14. Repair competence assay in studies of the influence of environmental exposure to c-PAHs on individual susceptibility to induction of DNA damage

    International Nuclear Information System (INIS)

    Cebulska-Wasilewska, Antonina; Binkova, Blanka; Sram, Radim J.; Kalina, Ivan; Popov, Teodor; Farmer, Peter B.

    2007-01-01

    susceptibility in molecular epidemiology or preclinical studies, aimed at predicting susceptibility to various genotoxic exposures (environmental, occupational, therapeutic). To conclude, the research proved the influence of environmental c-PAHs, genotypes, and life styles on DNA damage and on its repair efficiency. Even low exposure to environmental c-PAHs altered DNA repair abilities of the subjects, which may result in an increased cancer risk. The findings confirm that c-PAHs should become pollutants that are subject to regulation

  15. Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: implications for gene regulation and virulence.

    Science.gov (United States)

    Tan, Aimee; Hill, Dorothea M C; Harrison, Odile B; Srikhanta, Yogitha N; Jennings, Michael P; Maiden, Martin C J; Seib, Kate L

    2016-02-12

    Neisseria meningitidis is a human-specific bacterium that varies in invasive potential. All meningococci are carried in the nasopharynx, and most genotypes are very infrequently associated with invasive meningococcal disease; however, those belonging to the 'hyperinvasive lineages' are more frequently associated with sepsis or meningitis. Genome content is highly conserved between carriage and disease isolates, and differential gene expression has been proposed as a major determinant of the hyperinvasive phenotype. Three phase variable DNA methyltransferases (ModA, ModB and ModD), which mediate epigenetic regulation of distinct phase variable regulons (phasevarions), have been identified in N. meningitidis. Each mod gene has distinct alleles, defined by their Mod DNA recognition domain, and these target and methylate different DNA sequences, thereby regulating distinct gene sets. Here 211 meningococcal carriage and >1,400 disease isolates were surveyed for the distribution of meningococcal mod alleles. While modA11-12 and modB1-2 were found in most isolates, rarer alleles (e.g., modA15, modB4, modD1-6) were specific to particular genotypes as defined by clonal complex. This suggests that phase variable Mod proteins may be associated with distinct phenotypes and hence invasive potential of N. meningitidis strains.

  16. Repair competence assay in studies of the influence of environmental exposure to c-PAHs on individual susceptibility to induction of DNA damage

    Energy Technology Data Exchange (ETDEWEB)

    Cebulska-Wasilewska, Antonina [Department of Radiation and Environmental Biology, H. Niewodniczanski Institute of Nuclear Physics PAN, Radzikowskiego 152, 31-342 Cracow (Poland) and Chair of the Epidemiology and Preventive Medicine, Collegium Medicum of Jagiellonian University, Cracow (Poland)]. E-mail: b7wasile@cyf-kr.edu.pl; Binkova, Blanka [Institute of Experimental Medicine AS CR and Health Institute of Central Bohemia, Prague (Czech Republic); Sram, Radim J. [Institute of Experimental Medicine AS CR and Health Institute of Central Bohemia, Prague (Czech Republic); Kalina, Ivan [Department of Molecular Biology of the P.J. Safarik University, Kosice (Slovakia); Popov, Teodor [Department of Toxicology, National Center of Public Health Protection, Sofia (Bulgaria); Farmer, Peter B. [Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester (United Kingdom)

    2007-07-01

    acetylators, for the control group was 68.0% versus significantly less in the exposed subjects, 60.6%, p < 0.05). Smoking habits, or the diet's vitamin content, significantly affected the process. The results obtained confirm a potential value of the method as a biomarker of susceptibility in molecular epidemiology or preclinical studies, aimed at predicting susceptibility to various genotoxic exposures (environmental, occupational, therapeutic). To conclude, the research proved the influence of environmental c-PAHs, genotypes, and life styles on DNA damage and on its repair efficiency. Even low exposure to environmental c-PAHs altered DNA repair abilities of the subjects, which may result in an increased cancer risk. The findings confirm that c-PAHs should become pollutants that are subject to regulation.

  17. RELAP5/MOD2 code assessment

    International Nuclear Information System (INIS)

    Nithianandan, C.K.; Shah, N.H.; Schomaker, R.J.; Miller, F.R.

    1985-01-01

    Babcock and Wilcox (B and W) has been working with the code developers at EG and G and the US Nuclear Regulatory Commission in assessing the RELAP5/MOD2 computer code for the past year by simulating selected separate-effects tests. The purpose of this assessment has been to evaluate the code for use in MIST (Ref. 2) and OTIS integral system tests simulations and in the prediction of pressurized water reactor transients. B and W evaluated various versions of the code and made recommendations to improve code performance. As a result, the currently released version (cycle 36.1) has been improved considerably over earlier versions. However, further refinements to some of the constitutive models may still be needed to further improve the predictive capability of RELAP5/MOD2. The following versions of the code were evaluated. (1) RELAP/MOD2/Cycle 22 - first released version; (2) YELAP5/Cycle 32 - EG and G test version of RELAP5/MOD2/Cycle 32; (3) RELAP5/MOD2/Cycle 36 - frozen cycle for international code assessment; (4) updates to cycle 36 based on recommendations developed by B and W during the simulation of a Massachusetts Institute of Technology (MIT) pressurizer test; and (5) cycle 36.1 updates received from EG and G

  18. RELAP5/MOD2 code assessment

    Energy Technology Data Exchange (ETDEWEB)

    Nithianandan, C.K.; Shah, N.H.; Schomaker, R.J.; Miller, F.R.

    1985-11-01

    Babcock and Wilcox (B and W) has been working with the code developers at EG and G and the US Nuclear Regulatory Commission in assessing the RELAP5/MOD2 computer code for the past year by simulating selected separate-effects tests. The purpose of this assessment has been to evaluate the code for use in MIST (Ref. 2) and OTIS integral system tests simulations and in the prediction of pressurized water reactor transients. B and W evaluated various versions of the code and made recommendations to improve code performance. As a result, the currently released version (cycle 36.1) has been improved considerably over earlier versions. However, further refinements to some of the constitutive models may still be needed to further improve the predictive capability of RELAP5/MOD2. The following versions of the code were evaluated. (1) RELAP/MOD2/Cycle 22 - first released version; (2) YELAP5/Cycle 32 - EG and G test version of RELAP5/MOD2/Cycle 32; (3) RELAP5/MOD2/Cycle 36 - frozen cycle for international code assessment; (4) updates to cycle 36 based on recommendations developed by B and W during the simulation of a Massachusetts Institute of Technology (MIT) pressurizer test; and (5) cycle 36.1 updates received from EG and G.

  19. RELAP5/MOD3 code coupling model

    International Nuclear Information System (INIS)

    Martin, R.P.; Johnsen, G.W.

    1994-01-01

    A new capability has been incorporated into RELAP5/MOD3 that enables the coupling of RELAP5/MOD3 to other computer codes. The new capability has been designed to support analysis of the new advanced reactor concepts. Its user features rely solely on new RELAP5 open-quotes styledclose quotes input and the Parallel Virtual Machine (PVM) software, which facilitates process management and distributed communication of multiprocess problems. RELAP5/MOD3 manages the input processing, communication instruction, process synchronization, and its own send and receive data processing. The flexible capability requires that an explicit coupling be established, which updates boundary conditions at discrete time intervals. Two test cases are presented that demonstrate the functionality, applicability, and issues involving use of this capability

  20. CORCON-MOD1 modelling improvements

    International Nuclear Information System (INIS)

    Corradini, M.L.; Gonzales, F.G.; Vandervort, C.L.

    1986-01-01

    Given the unlikely occurrence of a severe accident in a light water reactor (LWR), the core may melt and slump into the reactor cavity below the reactor vessel. The interaction of the molten core with exposed concrete (a molten-core-concrete-interaction, MCCI) causes copious gas production which influences further heat transfer and concrete attack and may threaten containment integrity. In this paper the authors focus on the low-temperature phase of the MCCI where the molten pool is partially solidified, but is still capable of attacking concrete. The authors have developed some improved phenomenological models for pool freezing and molten core-coolant heat transfer and have incorporated them into the CORCON-MOD1 computer program. In the paper the authors compare the UW-CORCON/MOD1 calculations to CORCON/MOD2 and WECHSL results as well as the BETA experiments which are being conducted in Germany

  1. Alcator C-MOD proposal addendum

    International Nuclear Information System (INIS)

    Bonoli, P.; Greenwald, M.; Gwinn, D.

    1986-04-01

    Since the design concept and overall purpose of the Alcator C-MOD device are similar to that proposed in October 1985, we have chosen in this document only to highlight areas where changes or additions have been made. Chapters in the Addendum correspond to those in the Proposal, except Chapter 9 which describes a number of toroidal improvement concepts which are being considered for inclusion in the Alcator C-MOD experimental program. A description of the redesign and a discussion of the objectives of the experimental program are given

  2. Qualification of the AUTOBUS Mod. 2 Code

    International Nuclear Information System (INIS)

    Ciarniello, U.; Peroni, P.

    1988-01-01

    The paper presents the qualification of AUTOBUS MOD.2 code. After a brief description of the code itself, all the critical experiments simulated by the code are illustrated to prove the accuracy of criticality calculation and power distribution. An interpretation of the results and a conclusion close this presentation

  3. Vold mod børn

    DEFF Research Database (Denmark)

    Christensen, Else; Agerlund Sloth Larsen, Dorthe

    er der gennemført en interviewundersøgelse, hvor i alt 14 sagsbehandlere fra fire forskellige store kommuner er interviewet om deres erfaringer fra sager med (mistanke om) fysisk vold mod børn, om hvordan sådanne sager sædvanligvis starter i socialforvaltningen, om undersøgelsesforløbet, om...

  4. Udvikling af vaccine mod dyr tarmsygdom

    DEFF Research Database (Denmark)

    Jungersen, Gregers

    2012-01-01

    DTU Veterinærinstituttet arbejder på at udvikle en effektiv vaccine mod bakterien Lawsonia intracellularis, der forårsager den antibiotikakrævende tarmsygdom proliferativ enteritis. Bakterien driller i laboratoriet, så forskerne må finde innovative veje til vaccinen. Målet er, at vaccinens...

  5. RETRAN02/MOD02: an outside perspective

    International Nuclear Information System (INIS)

    Wei, T.Y.C.

    1984-03-01

    ANL recently participated in a review of the RETRAN02/MOD02 code to determine the range of accuracy, the reliability and the reproducibility of results obtained with the code for Chapter 15 non-LOCA system transients for both pressurized water reactors (PWRs) and boiling water reactors (BWRs). This paper summarizes the technical aspects of that review

  6. Kyllinger har effektivt immunforsvar mod herpes

    DEFF Research Database (Denmark)

    Buchmann, Kurt

    2008-01-01

    Forskere ved Københavns Universitet, Fakultet for Biovidenskab har studeret kyllingens MHC molekyler og kan derigennem forklare hvorfor en særlig stamme indenfor denne art er modstandsdygtige mod en særlig herpesvirus. Udgivelsesdato: 18. januar 2008...

  7. GeoMod 2014 - Modelling in geoscience

    Science.gov (United States)

    Leever, Karen; Oncken, Onno

    2016-08-01

    GeoMod is a biennial conference to review and discuss latest developments in analogue and numerical modelling of lithospheric and mantle deformation. GeoMod2014 took place at the GFZ German Research Centre for Geosciences in Potsdam, Germany. Its focus was on rheology and deformation at a wide range of temporal and spatial scales: from earthquakes to long-term deformation, from micro-structures to orogens and subduction systems. It also addressed volcanotectonics and the interaction between tectonics and surface processes (Elger et al., 2014). The conference was followed by a 2-day short course on "Constitutive Laws: from Observation to Implementation in Models" and a 1-day hands-on tutorial on the ASPECT numerical modelling software.

  8. Automotive Stirling engine: Mod 2 design report

    Science.gov (United States)

    Nightingale, Noel P.

    1986-01-01

    The design of an automotive Stirling engine that achieves the superior fuel economy potential of the Stirling cycle is described. As the culmination of a 9-yr development program, this engine, designated the Mod 2, also nullifies arguments that Stirling engines are heavy, expensive, unreliable, demonstrating poor performance. Installed in a General Motors Chevrolet Celebrity car, this engine has a predicted combined fuel economy on unleaded gasoline of 17.5 km/l (41 mpg)- a value 50% above the current vehicle fleet average. The Mod 2 Stirling engine is a four-cylinder V-drive design with a single crankshaft. The engine is also equipped with all the controls and auxiliaries necessary for automotive operation.

  9. Study of MOD control system in ECRH

    International Nuclear Information System (INIS)

    Su Yu; Liu Baohua; Ding Tonghai; Kuang Guangli

    2005-01-01

    High-voltage power supply (HVPS) is one of the important components in ECRH (Electron Cyclotron Resonance Heating). The MOD (modulator) control system is a key of the operation of HVPS and the whole system. The background and principium is introduced in this paper, especially the detail of the hardware and software of the control system is shown. The experiment, that shows stability, accuracy and reliability had reached the expected goal. (authors)

  10. Alcator C-MOD final safety analysis

    International Nuclear Information System (INIS)

    Fiore, C.L.

    1989-06-01

    This document is designed to address the safety issues involved with the Alcator C-Mod project. This report will begin with a brief description of the experimental objectives which will be followed by information concerning the site. The Alcator C-Mod experiment is a pulsed fusion experiment in which a plasma formed from small amounts of hydrogen or deuterium gas is confined in a magnetic field for short periods (∼1 s). No radioactive fuels or fissile materials are used in the device, so that no criticality hazard exists and no credible nuclear accident can occur. During deuterium operation, the production of a small number of neutrons from a short pulse could result in a small amount of short- and intermediate-lived radioactive isotopes being produced inside the experimental cell. This report will demonstrate that this does not pose an additional hazard to the general population. The health and safety hazards resulting from Alcator C-Mod occur to the workers on the experiment, each of which is described in its own chapter with the steps taken to minimize the risk to employees. These hazards include fire, chemicals and cryogenics, air quality, electrical, electromagnetic radiation, ionizing radiation, and mechanical and natural phenomena. None of these hazards is unique to the facility, and methods of protection from them are well defined and are discussed in the chapter which describes each hazard. The quality assurance program, critical to ensuring the safety aspects of the program, will also be described

  11. RELAP5/MOD3 AP600 problems

    International Nuclear Information System (INIS)

    Riemke, R.A.

    1993-01-01

    RELAP5/MOD3 is a reactor systems analysis code that has been developed jointly by the US Nuclear Regulatory Commission (USNRC) and a consortium consisting of several of the countries and domestic organizations that were members of the International Code Assessment and Applications Program (ICAP). The code is currently being used to simulate transients for the next generation of advanced light water reactors (ALWR's). One particular reactor design is the Westinghouse AP600 pressurized water reactor (PWR), which consists of two hot legs and four cold legs as well as passive emergency core cooling (ECC) systems. Initial calculations with RELAP5/MOD3 indicated that the code was not as robust as RELAP5/MOD2.5 with regard to AP600 calculations. Recent modifications in the areas of condensation wall heat transfer, interfacial heat transfer in the presence of noncondensibles, bubbly flow interfacial heat transfer, and time smoothing of both interfacial drag and interfacial heat transfer have improved the robustness, although more reliability is needed

  12. Susceptibility Testing

    Science.gov (United States)

    ... Marker Bicarbonate (Total CO2) Bilirubin Blood Culture Blood Gases Blood Ketones Blood Smear Blood Typing Blood Urea ... hours depending on the method used. There are commercial tests available that offer rapid susceptibility testing and ...

  13. An analysis of the binding of repressor protein ModE to modABCD (molybdate transport) operator/promoter DNA of Escherichia coli.

    Science.gov (United States)

    Grunden, A M; Self, W T; Villain, M; Blalock, J E; Shanmugam, K T

    1999-08-20

    Expression of the modABCD operon in Escherichia coli, which codes for a molybdate-specific transporter, is repressed by ModE in vivo in a molybdate-dependent fashion. In vitro DNase I-footprinting experiments identified three distinct regions of protection by ModE-molybdate on the modA operator/promoter DNA, GTTATATT (-15 to -8; region 1), GCCTACAT (-4 to +4; region 2), and GTTACAT (+8 to +14; region 3). Within the three regions of the protected DNA, a pentamer sequence, TAYAT (Y = C or T), can be identified. DNA-electrophoretic mobility experiments showed that the protected regions 1 and 2 are essential for binding of ModE-molybdate to DNA, whereas the protected region 3 increases the affinity of the DNA to the repressor. The stoichiometry of this interaction was found to be two ModE-molybdate per modA operator DNA. ModE-molybdate at 5 nM completely protected the modABCD operator/promoter DNA from DNase I-catalyzed hydrolysis, whereas ModE alone failed to protect the DNA even at 100 nM. The apparent K(d) for the interaction between the modA operator DNA and ModE-molybdate was 0.3 nM, and the K(d) increased to 8 nM in the absence of molybdate. Among the various oxyanions tested, only tungstate replaced molybdate in the repression of modA by ModE, but the affinity of ModE-tungstate for modABCD operator DNA was 6 times lower than with ModE-molybdate. A mutant ModE(T125I) protein, which repressed modA-lac even in the absence of molybdate, protected the same region of modA operator DNA in the absence of molybdate. The apparent K(d) for the interaction between modA operator DNA and ModE(T125I) was 3 nM in the presence of molybdate and 4 nM without molybdate. The binding of molybdate to ModE resulted in a decrease in fluorescence emission, indicating a conformational change of the protein upon molybdate binding. The fluorescence emission spectra of mutant ModE proteins, ModE(T125I) and ModE(Q216*), were unaffected by molybdate. The molybdate-independent mutant Mod

  14. Orbit Representations from Linear mod 1 Transformations

    Directory of Open Access Journals (Sweden)

    Carlos Correia Ramos

    2012-05-01

    Full Text Available We show that every point $x_0in [0,1]$ carries a representationof a $C^*$-algebra that encodes the orbit structure of thelinear mod 1 interval map $f_{eta,alpha}(x=eta x +alpha$. Such $C^*$-algebra is generated by partial isometries arising from the subintervals of monotonicity of the underlying map $f_{eta,alpha}$. Then we prove that such representation is irreducible. Moreover two such of representations are unitarily equivalent if and only if the points belong to the same generalized orbit, for every $alphain [0,1[$ and $etageq 1$.

  15. Vector models in RETRAN-02 MOD 2

    International Nuclear Information System (INIS)

    Kinnersly, S.R.

    1985-06-01

    The vector momentum model in RETRAN-02 allows momentum flux to be modelled in two dimensions. Vector models in RETRAN-2 are described, including both the actual implementation in the code and the specification given in the code manual. The vector momentum model is described in detail. Other models which use vector quantities include models for volume average flow, volume average slip velocity, volume average phase velocities and fill junction flows. Both code implementations and code manual descriptions are described and inconsistencies noted. The differences between the standard RETRA-02 Mod 2 version and the Winfrith version RETN2204 are noted. (U.K.)

  16. R-HyMOD: an R-package for the hydrological model HyMOD

    Science.gov (United States)

    Baratti, Emanuele; Montanari, Alberto

    2015-04-01

    A software code for the implementation of the HyMOD hydrological model [1] is presented. HyMOD is a conceptual lumped rainfall-runoff model that is based on the probability-distributed soil storage capacity principle introduced by R. J. Moore 1985 [2]. The general idea behind this model is to describe the spatial variability of some process parameters as, for instance, the soil structure or the water storage capacities, through probability distribution functions. In HyMOD, the rainfall-runoff process is represented through a nonlinear tank connected with three identical linear tanks in parallel representing the surface flow and a slow-flow tank representing groundwater flow. The model requires the optimization of five parameters: Cmax (the maximum storage capacity within the watershed), β (the degree of spatial variability of the soil moisture capacity within the watershed), α (a factor for partitioning the flow between two series of tanks) and the two residence time parameters of quick-flow and slow-flow tanks, kquick and kslow respectively. Given its relatively simplicity but robustness, the model is widely used in the literature. The input data consist of precipitation and potential evapotranspiration at the given time scale. The R-HyMOD package is composed by a 'canonical' R-function of HyMOD and a fast FORTRAN implementation. The first one can be easily modified and can be used, for instance, for educational purposes; the second part combines the R user friendly interface with a fast processing unit. [1] Boyle D.P. (2000), Multicriteria calibration of hydrological models, Ph.D. dissertation, Dep. of Hydrol. and Water Resour., Univ of Arizona, Tucson. [2] Moore, R.J., (1985), The probability-distributed principle and runoff production at point and basin scale, Hydrol. Sci. J., 30(2), 273-297.

  17. Ny vaccine mod ledbetændelse er ikke effektiv

    DEFF Research Database (Denmark)

    Nielsen, Elisabeth Okholm; Lauritsen, Klara Tølbøll

    2013-01-01

    En ny mulighed for at vaccinere mod mykoplasma-ledbetændelse er undersøgt hos en slagtesvineproducent. Vaccinen kunne desværre ikke forebygge halthed eff ektivt.......En ny mulighed for at vaccinere mod mykoplasma-ledbetændelse er undersøgt hos en slagtesvineproducent. Vaccinen kunne desværre ikke forebygge halthed eff ektivt....

  18. Waste removal sequencing using ProdMod

    International Nuclear Information System (INIS)

    Paul, P.K.; Gregory, M.V.; Davis, N.R.; Brooke, J.N.

    1996-01-01

    The Savannah River Site (SRS) is starting to solidify its accumulated high-level radioactive waste into borosilicate glass in stainless steel canisters for eventual permanent storage. The in-tank precipitation process (ITP) and extended sludge processing (ESP) are two key operations in the waste processing complex. The supernate and dissolved salt from the waste storage tanks are transferred to the ITP process tank where the solution is decontaminated in batch processes. Soluble radioactive cesium is precipitated with sodium tetraphenylborate and strontium, uranium, and plutonium are adsorbed on monosodium titanate. The precipitate and adsorbent solids, which now contain the radionuclides, are concentrated using crossflow filters. The concentrated solids are sent to the high-level waste vitrification process. The decontaminated salt solution is sent to the low-level waste solidification process to form cement grout. In parallel with the precipitate operations, insoluble sludges that settled originally to the bottom of the waste tanks are reslurried and sent to ESP to undergo washing to reduce soluble salt content and aluminum dissolution, if required. In the vitrification process in the Defense Waste Processing Facility (DWPF), the concentrated precipitate from the ITP is mixed with the washed sludge from ESP and glass frit in proportion to form a stable borosilicate glass. A novel and fast-running Production Planning Model (ProdMod) has been developed to simulate the waste processing operation. This paper describes the application of ProdMod in sequencing the ITP batches and scheduling the ESP batches

  19. The alcator C-MOD control system

    International Nuclear Information System (INIS)

    Bosco, J.; Fairfax, S.

    1992-01-01

    The Alcator C-MOD experiment includes over 30 engineering and diagnostic subsystems. The control system hardware and software is a mixture of custom and commercial products which includes sensors, signal conditioners, hard-wired controls, programmable logic controllers, displays, a hybrid analog/digital computer, networked personal computers, and networked VAX workstations. This paper describes the computer-based portions of the control system. The control system coordinates all C-MOD systems including power, vacuum, heating and cooling, access control, plasma shape and position control, and diagnostics. Programmable logic controllers (PLC's) are located near each subsystem. The control room is isolated by fiber optics. Functions that are essential to personnel or equipment safety (e.g. access control) are implemented in hardwired logic and monitored but not controlled by the PLC's. The initial configuration will include over 25 Allen-Bradley PLC-5 units. The PLCs in each subsystem are connected to personal computers (PC's) in the control room. The PC's provide graphical displays and operator interface. The Pc's are networked and share process data with each other and with a master control console and a large mimic panel

  20. Mechanical measurements in RFX-mod experiment

    Energy Technology Data Exchange (ETDEWEB)

    Dalla Palma, M., E-mail: mauro.dallapalma@igi.cnr.it [Consorzio RFX, EURATOM-ENEA Association, Corso Stati Uniti 4, 35127 Padova (Italy); Ravarotto, D.; Dal Bello, S.; Fincato, M.; Ghiraldelli, R.; Marchiori, G.; Taliercio, C.; Zaccaria, P. [Consorzio RFX, EURATOM-ENEA Association, Corso Stati Uniti 4, 35127 Padova (Italy)

    2010-12-15

    The ongoing experimental campaigns of RFX-mod are performed setting operational parameters at the nominal or exceeding design values of the experiment. Compressive forces up to 11 MN are produced by high magnetizing currents that reach values up to 50 kA. These forces heavily load the mechanical structure of RFX-mod and their effects are measured and monitored in order to assess the expected structural response and machine reliability during operation. Mechanical strains and relative displacements are real time measured during each experimental pulse by 48 strain gauges located on 12 mechanical struts and 16 potentiometers positioned between the toroidal assembly and the support mechanical structure. The strains in the most stressed components are measured by means of 24 half bridge gauges preliminarily calibrated. Particular care has been given to sensor choices and installation in order to minimize signal noises induced by the electrical and magnetic fields. The residual noises have been further reduced by proper sampling frequency and averaging techniques. The strains measured on the struts are then post-processed to calculate the resultant forces and bending moments, while the displacement measurements give an estimate of the overall stiffness of the mechanical structure. The measured forces and displacements are shown per toroidal locations and as a function of the current intensity, so verifying the uniform sharing of forces among the different struts and the proper square law correlation with the magnetizing current intensity.

  1. Beskyttelse mod passiv rygning i botilbud

    DEFF Research Database (Denmark)

    Faber, Louise

    2018-01-01

    ikke tidligere har været forbud. Denne problemstilling er aktuelt lige nu i forhold til passiv rygning, der tolereres mindre end tidligere. I denne artikel undersøges, i hvilket omfang der er mulighed for, at udstede rygeforbud på botilbud, når formålet med forbuddet er at beskytte andre beboere mod......Myndigheder har pligt til at beskytte individer mod ufrivillig sundhedsskadelig påvirkning i medfør af EMRK art. 8, stk. 1. På områder, hvor individets tolerancetærskel for sundhedsskadelig påvirkning bliver mindre end tidligere, kan der opstå behov for at udstede forbud i situationer, hvor der...... ufrivillig passiv rygning. Problemstilingen belyses i en forvaltningsretlig kontekst med udgangspunkt i dansk ret. Forfatteren konkluderer, at der er hjemmel i den danske Lov om Røgfrie Miljøer til at forbyde rygning, men at reglerne ikke giver tilstrækkelig beskyttelse i den situation, hvor en beboer...

  2. Molybdate binding by ModA, the periplasmic component of the Escherichia coli mod molybdate transport system.

    Science.gov (United States)

    Imperial, J; Hadi, M; Amy, N K

    1998-03-13

    ModA, the periplasmic-binding protein of the Escherichia coli mod transport system was overexpressed and purified. Binding of molybdate and tungstate to ModA was found to modify the UV absorption and fluorescence emission spectra of the protein. Titration of these changes showed that ModA binds molybdate and tungstate in a 1:1 molar ratio. ModA showed an intrinsic fluorescence emission spectrum attributable to its three tryptophanyl residues. Molybdate binding caused a conformational change in the protein characterized by: (i) a shift of tryptophanyl groups to a more hydrophobic environment; (ii) a quenching (at pH 5.0) or enhancement (at pH 7.8) of fluorescence; and (iii) a higher availability of tryptophanyl groups to the polar quencher acrylamide. The tight binding of molybdate did not allow an accurate estimation of the binding constants by these indirect methods. An isotopic binding method with 99MoO42- was used for accurate determination of KD (20 nM) and stoichiometry (1:1 molar ratio). ModA bound tungstate with approximately the same affinity, but did not bind sulfate or phosphate. These KDs are 150- to 250-fold lower than those previously reported, and compatible with the high molybdate transport affinity of the mod system. The affinity of ModA for molybdate was also determined in vivo and found to be similar to that determined in vitro. Copyright 1998 Elsevier Science B.V.

  3. Functional characterization of the Bradyrhizobium japonicum modA and modB genes involved in molybdenum transport.

    Science.gov (United States)

    Delgado, María J; Tresierra-Ayala, Alvaro; Talbi, Chouhra; Bedmar, Eulogio J

    2006-01-01

    A modABC gene cluster that encodes an ABC-type, high-affinity molybdate transporter from Bradyrhizobium japonicum has been isolated and characterized. B. japonicum modA and modB mutant strains were unable to grow aerobically or anaerobically with nitrate as nitrogen source or as respiratory substrate, respectively, and lacked nitrate reductase activity. The nitrogen-fixing ability of the mod mutants in symbiotic association with soybean plants grown in a Mo-deficient mineral solution was severely impaired. Addition of molybdate to the bacterial growth medium or to the plant mineral solution fully restored the wild-type phenotype. Because the amount of molybdate required for suppression of the mutant phenotype either under free-living or under symbiotic conditions was dependent on sulphate concentration, it is likely that a sulphate transporter is also involved in Mo uptake in B. japonicum. The promoter region of the modABC genes has been characterized by primer extension. Reverse transcription and expression of a transcriptional fusion, P(modA)-lacZ, was detected only in a B. japonicum modA mutant grown in a medium without molybdate supplementation. These findings indicate that transcription of the B. japonicum modABC genes is repressed by molybdate.

  4. VARSKIN MOD 2 and SADDE MOD2: Computer codes for assessing skin dose from skin contamination

    International Nuclear Information System (INIS)

    Durham, J.S.

    1992-12-01

    The computer code VARSKIN has been modified to calculate dose to skin from three-dimensional sources, sources separated from the skin by layers of protective clothing, and gamma dose from certain radionuclides correction for backscatter has also been incorporated for certain geometries. This document describes the new code, VARSKIN Mod 2, including installation and operation instructions, provides detailed descriptions of the models used, and suggests methods for avoiding misuse of the code. The input data file for VARSKIN Mod 2 has been modified to reflect current physical data, to include the contribution to dose from internal conversion and Auger electrons, and to reflect a correction for low-energy electrons. In addition, the computer code SADDE: Scaled Absorbed Dose Distribution Evaluator has been modified to allow the generation of scaled absorbed dose distributions for mixtures of radionuclides and intereat conversion and Auger electrons. This new code, SADDE Mod 2, is also described in this document. Instructions for installation and operation of the code and detailed descriptions of the models used in the code are provided

  5. RELAP5/MOD2 models and correlations

    International Nuclear Information System (INIS)

    Dimenna, R.A.; Larson, J.R.; Johnson, R.W.; Larson, T.K.; Miller, C.S.; Streit, J.E.; Hanson, R.G.; Kiser, D.M.

    1988-08-01

    A review of the RELAP5/MOD2 computer code has been performed to assess the basis for the models and correlations comprising the code. The review has included verification of the original data base, including thermodynamic, thermal-hydraulic, and geothermal conditions; simplifying assumptions in implementation or application; and accuracy of implementation compared to documented descriptions of each of the models. An effort has been made to provide the reader with an understanding of what is in the code and why it is there and to provide enough information that an analyst can assess the impact of the correlation or model on the ability of the code to represent the physics of a reactor transient. Where assessment of the implemented versions of the models or correlations has been accomplished and published, the assessment results have been included

  6. Alcator C-Mod predictive modeling

    International Nuclear Information System (INIS)

    Pankin, Alexei; Bateman, Glenn; Kritz, Arnold; Greenwald, Martin; Snipes, Joseph; Fredian, Thomas

    2001-01-01

    Predictive simulations for the Alcator C-mod tokamak [I. Hutchinson et al., Phys. Plasmas 1, 1511 (1994)] are carried out using the BALDUR integrated modeling code [C. E. Singer et al., Comput. Phys. Commun. 49, 275 (1988)]. The results are obtained for temperature and density profiles using the Multi-Mode transport model [G. Bateman et al., Phys. Plasmas 5, 1793 (1998)] as well as the mixed-Bohm/gyro-Bohm transport model [M. Erba et al., Plasma Phys. Controlled Fusion 39, 261 (1997)]. The simulated discharges are characterized by very high plasma density in both low and high modes of confinement. The predicted profiles for each of the transport models match the experimental data about equally well in spite of the fact that the two models have different dimensionless scalings. Average relative rms deviations are less than 8% for the electron density profiles and 16% for the electron and ion temperature profiles

  7. Overexpression, purification, and partial characterization of ADP-ribosyltransferases modA and modB of bacteriophage T4.

    Science.gov (United States)

    Tiemann, B; Depping, R; Rüger, W

    1999-01-01

    There is increasing experimental evidence that ADP-ribosylation of host proteins is an important means to regulate gene expression of bacteriophage T4. Surprisingly, this phage codes for three different ADP-ribosyltransferases, gene products Alt, ModA, and ModB, modifying partially overlapping sets of host proteins. While gene product Alt already has been isolated as a recombinant protein and its action on host RNA polymerases and transcription regulation have been studied, the nucleotide sequences of the two mod genes was published only recently. Their mode of action in the course of the infection cycle and the consequences of the ADP-ribosylations catalyzed by these enzymes remain to be investigated. Here we describe the cloning of the genes, the overexpression, purification, and partial characterization of ADP-ribosyltransferases ModA and ModB. Both proteins seem to act independently, and the ADP-ribosyl moieties are transferred to different sets of host proteins. While gene product ModA, similarly to the Alt protein, acts also on the alpha-subunit of host RNA polymerase, the ModB activity serves another set of proteins, one of which was identified as the S1 protein associated with the 30S subunit of the E. coli ribosomes.

  8. RELAP5/MOD2 code assessment for the Semiscale Mod-2C Test S-LH-1

    International Nuclear Information System (INIS)

    Fineman, C.P.

    1986-01-01

    RELAP5/MOD2, Cycle 36.02, was assessed using data from Semiscale Mod-2C experiment S-LH-1. The major phenomena that occurred during the experiment were calculated by RELAP5/MOD2, although the duration and the magnitude of their effect on the transient were not always well calculated. Areas defined where further work was needed to improve the RELAP5 calculation include: (1) the system energy balance, (2) core interfacial drag, and 3) the heat transfer logic rod dryout criterion

  9. TRAC-PF1/MOD2 status and plans

    International Nuclear Information System (INIS)

    Spore, J.W.; Steinke, R.G.; Nelson, R.A.; Cappiello, M.W.; Jenks, R.

    1989-01-01

    The development of the TRAC-PF1/MOD1 code was completed in July 1988 with the release of Version 14.4. A TRAC-PF1/MOD2 code development plan addresses code deficiencies identified in the MOD1 code in order to provide an accurate and defensible tool that can be used to simulate large-break loss-of-coolant accidents (LOCAs), small-break LOCAs, and operational transients. The MOD2 code development plan is an international cooperative effort that includes contributions from Los Alamos National Laboratory, Idaho National Engineering Laboratory (INEL), Japanese Atomic Energy Research Institute (JAERI), Cray Research, Central Electricity Generating Board (CEGB), and United Kingdom Atomic Energy Authority (UKAEA)

  10. Characterization of the Hamamatsu 8" R5912-MOD Photomultiplier tube

    Science.gov (United States)

    Kaptanoglu, Tanner

    2018-05-01

    Current and future neutrino and direct detection dark matter experiments hope to take advantage of improving technologies in photon detection. Many of these detectors are large, monolithic optical detectors that use relatively low-cost, large-area, and efficient photomultiplier tubes (PMTs). A candidate PMT for future experiments is a newly developed prototype Hamamatsu PMT, the R5912-MOD. In this paper we describe measurements made of the single photoelectron time and charge response of the R5912-MOD, as well as detail some direct comparisons to similar PMTs. Most of these measurements were performed on three R5912-MOD PMTs operating at gains close to 1 × 107. The transit time spread (σ) and the charge peak-to-valley were measured to be on average 680ps and 4.2 respectively. The results of this paper show the R5912-MOD is an excellent candidate for future experiments in several regards, particularly due to its narrow spread in timing.

  11. Fatigue Properties of Aged Mod. 9Cr-1Mo

    International Nuclear Information System (INIS)

    Kim, Dae Whan; Kim, Sung Ho; Lee, Chan Bock

    2007-01-01

    Ferritic/Martensitic steel has a good mechanical properties and a lower thermal expansion coefficient than austenitic stainless steel. Mechanical property of Mod. 9Cr-1Mo steel is less than austenitic stainless steel at high temperature. High temperature mechanical properties are affected by precipitation for Mod. 9Cr-1Mo. FMS steel is used for long time at high temperature and the effect of aging on mechanical properties is very important. In this study, low cycle fatigue properties with aging were investigated

  12. Vaccine mod halthed testes i besætning

    DEFF Research Database (Denmark)

    Lauritsen, Klara Tølbøll

    2012-01-01

    Ny vaccine mod ledbetændelse forårsaget af Mycoplasma hyosynoviae testes nu hos 200 svin i en problembesætning. Håbet er færre halte svin og en nedbringelse af antibiotikaforbruget.......Ny vaccine mod ledbetændelse forårsaget af Mycoplasma hyosynoviae testes nu hos 200 svin i en problembesætning. Håbet er færre halte svin og en nedbringelse af antibiotikaforbruget....

  13. Using computer program RELAP5/MOD2 on microcomputers

    International Nuclear Information System (INIS)

    Grgic, D.; Bajs, T; Cavlina, N.; Debrecin, N.

    1990-01-01

    Our work on installation of RELAP5/MOD2 code on IBM4341, mVAX 11, MGT-386 and COMPAQ-386/20e computers is described. Main characteristics of RELAP5/MOD2 structure programming style and differences between FORTRAN VS, VAX-11 FORTRAN and NDP FORTRAN 386 are presented. We discussed basic philosophy used in modification and testing and test results. (author)

  14. RELAP5/MOD2: for PWR transient analysis

    International Nuclear Information System (INIS)

    Ransom, V.H.

    1983-01-01

    RELAP5 is a light water reactor system transient simulation code for use in nuclear plant safety analysis. Development of a new version, RELAP5/MOD2, has been completed and will be released to the United States Nuclear Regulatory Commission during September of 1983. The new and improved modeling capability of RELAP5/MOD2 is described and some developmental assessment results are presented. The future plans for extension to severe accident modeling are briefly discussed

  15. Assessment of RELAP5/MOD2 and RELAP5/MOD1-EUR codes on the basis of LOBI-MOD2 test results

    International Nuclear Information System (INIS)

    D'Auria, F.; Mazzini, M.; Oriolo, F.; Galassi, G.M.

    1989-10-01

    The present report deals with an overview of the application of RELAP5/MOD2 and RELAP5/MOD1-EUR codes to tests performed in the LOBI/MOD2 facility. The work has been carried out in the frame of a contract between Dipartimento di Costruzioni Meccaniche e Nucleari (DCMN) of Pisa University and CEC. The Universities of Roma, Pisa, Bologna and Palermo and the Polytechnic of Torino performed the post-test analysis of the LOBI experiment under the supervision of DCMN. In the report the main outcomes from the analysis of the LOBI experiments are given with the attempt to identify deficiencies in the modelling capabilities of the used codes

  16. Ohmic ITBs in Alcator C-Mod

    Science.gov (United States)

    Fiore, C. L.; Rowan, W. L.; Dominguez, A.; Hubbard, A. E.; Ince-Cushman, A.; Greenwald, M. J.; Lin, L.; Marmar, E. S.; Reinke, M.; Rice, J. E.; Zhurovich, K.

    2007-11-01

    Internal transport barrier plasmas can arise spontaneously in ohmic Alcator C-Mod plasmas where an EDA H-mode has been developed by magnetic field ramping. These ohmic ITBs share the hallmarks of ITBs created with off-axis ICRF injection in that they have highly peaked density and pressure profiles and the peaking can be suppressed by on-axis ICRF. There is a reduction of particle and thermal flux in the barrier region which then allows the neoclassical pinch to peak the central density. Recent work on ITB onset conditions [1] which was motivated by turbulence studies [2] points to the broadening of the Ti profile with off-axis ICRF acting to reduce the ion temperature gradient. This suppresses ITG instability driven particle fluxes, which is thought to be the primary mechanism for ITB formation. The object of this study is to examine the characteristics of ohmic ITBs to find whether the stability of plasmas and the plasma parameters support the onset model. [1]K. Zhurovich, et al., To be published in Nuclear Fusion [2] D. R. Ernst, et al., Phys. Plasmas 11, 2637 (2004)

  17. Overview of Alcator C-Mod Research

    Science.gov (United States)

    White, A. E.

    2017-10-01

    Alcator C-Mod, a compact (R =0.68m, a =0.21m), high magnetic field, Bt Research spans the topics of core transport and turbulence, RF heating and current drive, pedestal physics, scrape-off layer, divertor and plasma wall interactions. In the last experimental campaign, Super H-mode was explored and featured the highest pedestal pressures ever recorded, pped 90 kPa (90% of ITER target), consistent with EPED predictions. Optimization of naturally ELM-suppressed EDA H-modes accessed the highest volume averaged pressures ever achieved (〈p〉>2 atm), with pped 60 kPa. The SOL heat flux width has been measured at Bpol = 1.25T, confirming the Eich scaling over a broader poloidal field range than before. Multi-channel transport studies focus on the relationship between momentum transport and heat transport with perturbative experiments and new multi-scale gyrokinetic simulation validation techniques were developed. U.S. Department of Energy Grant No. DE-FC02-99ER54512.

  18. Edge Thomson scattering on RFX-mod

    International Nuclear Information System (INIS)

    Alfier, A.; Pasqualotto, R.

    2006-01-01

    Electron temperature and density profiles of the RFX-mod experiment are characterized by edge gradients typically steeper than the flatter central region. The main Thomson scattering (TS) diagnostic which measures 84-point profiles along a diameter is mainly devoted to cover the core region. A second TS system has been developed to measure 12-point profiles in the external region 0.8< r/a<1, with a spatial resolution of 1 cm. It uses a single shot ruby laser. Input and collection optics share the same vacuum port and they are mounted on one optical bench, which allows offline aligning the system before connecting it to the vessel. The scattered signal is collected by a row of 12 fibers, while 4 fibers on the sides are used to check the alignment and measure the plasma light. The fibers, arranged in a 4x4 pattern, are fed into a four channel filter spectrometer and the spectrum is detected by a GaAs intensified charge-coupled device camera. The filters are arranged in a zigzag geometry, such that only one detector is needed

  19. Gas jet disruption mitigation studies on Alcator C-Mod

    International Nuclear Information System (INIS)

    Granetz, R.; Whyte, D.G.; Izzo, V.A.; Biewer, T.; Reinke, M.L.; Terry, J.; Bader, A.; Bakhtiari, M.; Jernigan, T.; Wurden, G.

    2006-01-01

    Damaging effects of disruptions are a major concern for Alcator C-Mod, ITER and future tokamak reactors. High-pressure noble gas jet injection is a mitigation technique which potentially satisfies the operational requirements of fast response time and reliability, while still being benign to subsequent discharges. Disruption mitigation experiments using an optimized gas jet injection system are being carried out on Alcator C-Mod to study the physics of gas jet penetration into high pressure plasmas, as well as the ability of the gas jet impurities to convert plasma energy into radiation on timescales consistent with C-Mod's fast quench times, and to reduce halo currents given C-Mod's high-current density. The dependence of impurity penetration and effectiveness on noble gas species (He, Ne, Ar, Kr) is also being studied. It is found that the high-pressure neutral gas jet does not penetrate deeply into the C-Mod plasma, and yet prompt core thermal quenches are observed on all gas jet shots. 3D MHD modelling of the disruption physics with NIMROD shows that edge cooling of the plasma triggers fast growing tearing modes which rapidly produce a stochastic region in the core of the plasma and loss of thermal energy. This may explain the apparent effectiveness of the gas jet in C-Mod despite its limited penetration. The higher-Z gases (Ne, Ar, Kr) also proved effective at reducing halo currents and decreasing thermal deposition to the divertor surfaces. In addition, noble gas jet injection proved to be benign for plasma operation with C-Mod's metal (Mo) wall, actually improving the reliability of the startup in the following discharge

  20. Novel Tetra-Primer ARMS-PCR Assays for Thiopurine Intolerance Susceptibility Mutations NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C in East Asians

    Directory of Open Access Journals (Sweden)

    Chi-Chun Ho

    2017-10-01

    Full Text Available Thiopurines are clinically useful in the management of diverse immunological and malignant conditions. Nevertheless, these purine analogues can cause lethal myelosuppression, which may be prevented by prospective testing for variants in the thiopurine S-methyltransferase (TPMT and, in East Asians, Nudix hydrolase 15 (NUDT15 genes. Two single-tube, tetra-primer amplification refractory mutation system polymerase chain reaction (ARMS-PCR assays were developed to genotype the common loss-of-function variants NUDT15 c.415C>T (rs116855232 and TPMT*3C c.719A>G (rs1142345. In a group of 60 unselected patients, one and seven were found to be homozygous and heterozygous, respectively, for NUDT15 c.415C>T; one was found to be heterozygous for TPMT*3C c.719A>G. There was no non-specific amplification, and the genotypes were 100% concordant with Sanger sequencing. Limit-of-detection for both assays was below 1 ng of heterozygous template per reaction. Time- and cost-effective ARMS-PCR assays, suitable for genotyping East-Asian patients for thiopurine intolerance, were successfully developed and validated.

  1. SCDAP/RELAP5/MOD3 code development and assessment

    International Nuclear Information System (INIS)

    Allison, C.M.; Heath, C.H.; Siefken, L.J.; Hohorst, J.K.

    1991-01-01

    The SCDAP/RELAP5/MOD3 computer code is designed to describe the overall reactor coolant system (RCS) thermal-hydraulic response, core damage progression, and fission product release and transport during severe accidents. The code is being developed at the Idaho National Engineering Laboratory (INEL) under the primary sponsorship of the Office of Nuclear Regulatory Research of the Nuclear Regulatory Commission (NRC). SCDAP/RELAP5/MOD3, created in January, 1991, is the result of merging RELAP5/MOD3 with SCDAP and TRAP-MELT models from SCDAP/RELAP5/MOD2.5. The RELAP5 models calculate the overall RCS thermal-hydraulics, control system interactions, reactor kinetics, and the transport of noncondensible gases, fission products, and aerosols. The SCDAP models calculate the damage progression in the core structures, the formation, heatup, and melting of debris, and the creep rupture failure of the lower head and other RCS structures. The TRAP-MELT models calculate the deposition of fission products upon aerosols or structural surfaces; the formation, growth, or deposition of aerosols; and the evaporation of species from surfaces. The systematic assessment of modeling uncertainties in SCDAP/RELAP5 code is currently underway. This assessment includes (a) the evaluation of code-to-data comparisons using stand-alone SCDAP and SCDAP/RELAP5/MOD3, (b) the estimation of modeling and experimental uncertainties, and (c) the determination of the influence of those uncertainties on predicted severe accident behavior

  2. Hormone assay

    International Nuclear Information System (INIS)

    Eisentraut, A.M.

    1977-01-01

    An improved radioimmunoassay is described for measuring total triiodothyronine or total thyroxine levels in a sample of serum containing free endogenous thyroid hormone and endogenous thyroid hormone bound to thyroid hormone binding protein. The thyroid hormone is released from the protein by adding hydrochloric acid to the serum. The pH of the separated thyroid hormone and thyroid hormone binding protein is raised in the absence of a blocking agent without interference from the endogenous protein. 125 I-labelled thyroid hormone and thyroid hormone antibodies are added to the mixture, allowing the labelled and unlabelled thyroid hormone and the thyroid hormone antibody to bind competitively. This results in free thyroid hormone being separated from antibody bound thyroid hormone and thus the unknown quantity of thyroid hormone may be determined. A thyroid hormone test assay kit is described for this radioimmunoassay. It provides a 'single tube' assay which does not require blocking agents for endogenous protein interference nor an external solid phase sorption step for the separation of bound and free hormone after the competitive binding step; it also requires a minimum number of manipulative steps. Examples of the assay are given to illustrate the reproducibility, linearity and specificity of the assay. (UK)

  3. Assay system

    International Nuclear Information System (INIS)

    Patzke, J.B.; Rosenberg, B.J.

    1984-01-01

    The accuracy of assays for monitoring concentrations of basic drugs in biological fluids containing a 1 -acid glycoproteins, such as blood (serum or plasma), is improved by the addition of certain organic phosphate compounds to minimize the ''protein effect.'' Kits containing the elements of the invention are also disclosed

  4. Post-test analysis of LOBI BT-01 using RELAP5/MOD2 and RELAP5/MOD3

    International Nuclear Information System (INIS)

    Holmes, B.J.

    1991-08-01

    LOBI is a high pressure, electrically heated integral system test facility simulating a KWU 1300 MW PWR scaled 1:712 by volume, although full scale has been maintained in the vertical direction. This report describes the results of an analysis of test BT-01, which simulates a 10% steam line break. The bulk of the analysis was performed using the Project Version of RELAP5/MOD2, with additional calculations using RELAP5/MOD3 for comparison. The codes provided generally good agreement with data. In particular, the break flows were well modelled, although the mass flow data proved to be unreliable, and this conclusion had to be derived from interpreting other signals. RELAP over-predicted primary/secondary heat transfer in the broken loop, however, leading to a more rapid cool-down of the primary circuit. Furthermore, the primary side pressure response was critically dependent upon the pressuriser behaviour, and the correct timing of the uncovery of the surge line. Inter-phase drag was not well predicted in the broken loop steam generator intermals, although some improvement was seen in the RELAP5/MOD3 predictions. MOD3 gave a reduction in primary/secondary heat transfer during the test pre-conditioning phase, resulting in a lower secondary side pressure at the start of the transient compared with MOD2. (author)

  5. Plans and status of RELAP5/MOD3

    International Nuclear Information System (INIS)

    Weaver, W.L.

    1989-01-01

    RELAP5/MOD3 is a pressurized water reactor (PWR) system analysis code being developed jointly by the US Nuclear Regulatory Commission (USNRC) and consisting of several of the countries that are members of the International Code Assessment and Applications Program (ICAP). This code development program is called the ICAP Code Improvement Program. The mission of the RELAP5/MOD3 code improvement program is to develop a code version suitable for the analysis of all transients and postulated accidents in PER systems including both large and small break loss of coolant accidents (LOCA's) as well as the full range of operational transients. The emphasis of the RELAP5/MOD3 development will be on large break LOCA since previous versions of RELAP5 were developed for and assessed against small break LOCA and operation transient test data. The paper discusses the various code models to be improved and presents the results of work completed to date

  6. RELAP5/MOD2 assessment at Babcock and Wilcox

    International Nuclear Information System (INIS)

    Nithianandan, C.K.; Shah, N.H.; Schomaker, R.J.; Turk, C.

    1986-01-01

    Babcock and Wilcox (B and W) has been working with the code developers at EG and G Idaho, Inc. and the NRC assessing the RELAP5/MOD2 computer code by simulating selected separate effects tests. The purpose of this B and W Owners Group-sponsored assessment was to evaluate RELAP5/MOD2 for use in design calculations for the MIST and OTIS integral system tests and in predicting pressurized water reactor (PWR) transients. B and W evaluated various versions of the code and made recommendations to improve code performance. As a result, the currently released version (Cycle 36.1) has been improved considerably over earlier versions. However, further refinements to some of the constitutive models may still be needed to further improve specific predictive capabilities of RELAP5/MOD2

  7. NetMOD Version 2.0 Parameters

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    NetMOD ( Net work M onitoring for O ptimal D etection) is a Java-based software package for conducting simulation of seismic, hydroacoustic and infrasonic networks. Network simulations have long been used to study network resilience to station outages and to determine where additional stations are needed to reduce monitoring thresholds. NetMOD makes use of geophysical models to determine the source characteristics, signal attenuation along the path between the source and station, and the performance and noise properties of the station. These geophysical models are combined to simulate the relative amplitudes of signal and noise that are observed at each of the stations. From these signal-to-noise ratios (SNR), the probability of detection can be computed given a detection threshold. This document describes the parameters that are used to configure the NetMOD tool and the input and output parameters that make up the simulation definitions.

  8. Development of sorbent therapy for multiple organ dysfunction syndrome (MODS)

    International Nuclear Information System (INIS)

    Li Li; Pan Jilun; Yu Yaoting

    2007-01-01

    As a syndrome, multiple organ dysfunction (MODS) is defined as an altered organ function in the setting of sepsis, septic shock or systemic inflammatory response syndrome (SIRS) and is the most common cause of death in intensive care units. Endotoxin, a constituent of cell walls of Gram-negative bacteria, plays an important role in the initiation and development of MODS. The cytokines, especially tumor necrosis factor alpha (TNF-alpha), are early regulators of the immune response and can induce the release of secondary cytokines. To remove endotoxin and TNF-alpha from patients with MODS, the adsorption method has proven to be most effective. In this review, we provide various methods of removal of endotoxins and TNF-alpha using different adsorbents. (topical review)

  9. Brazilian Irradiation Project: CAFE-MOD1 validation experimental program

    International Nuclear Information System (INIS)

    Mattos, Joao Roberto Loureiro de; Costa, Antonio Carlos L. da; Esteves, Fernando Avelar; Dias, Marcio Soares

    1999-01-01

    The Brazilian Irradiation Project whose purpose is to provide Brazil with a minimal structure to qualify the design, fabrication and quality procedures of nuclear fuels, consists of three main facilities: IEA-R1 reactor of IPEN-CNEN/SP, CAFE-MOD1 irradiation device and a unit of hot cells. The CAFE-MOD1 is based on concepts successfully used for more than 20 years in the main nuclear institutes around the world. Despite these concepts are already proved it should be adapted to each reactor condition. For this purpose, there is an ongoing experimental program aiming at the certification of the criteria and operational limits of the CAFE-MOD1 in order to get the allowance for its installation at the IEA-R1 reactor. (author)

  10. Functional overview of the Production Planning Model (ProdMod)

    International Nuclear Information System (INIS)

    Gregory, M.V.; Paul, P.K.

    1995-09-01

    The Production Planning Model (ProdMod) has been developed by SRTC for use by High Level Waste Program Management and High Level Waste Engineering as a fast running, integrated, comprehensive model of the entire SRS high level waste (HLW) complex. ProdMod can simulate the response of the HLW complex from its current state to the end of tank clean-up or to any intermediate point. The present document describes the initial release of ProdMod at the end of FY95: a model version that contains all the significant elements from the High-level Waste System Plan Revision 5 and is capable of running the simulation all the way to the postulated completion of waste removal. For the scenario represented by this release, that simulates approximately 70 years of operation of the HLW complex (out to FY2065). This initial release of ProdMod will serve as the immediate starting point for the modeling of the High-Level Waste System Plan Revision 6. Thus ProdMod is expected to be in a state of continuous change and improvement.the initial goal has been to generate a simulation of the processes of interest, with the emphasis on mass and volume balances tracked throughout the HLW complex. That has been accomplished. Future development will add a set of cost equations to the process equations and extend the model for use as a linear programming (optimization) application. The goal of this later phase will be to free the ProdMod user to some extent from the need to set up detailed simulation scenarios: the model will automatically make operational choices which minimize or maximize a given objective function. Appendix A contains the source code

  11. Københavns Kommunes indsats mod social dumping - målopfyldelsesevaluering

    DEFF Research Database (Denmark)

    Baadsgaard, Kelvin; Jørgensen, Henning

    2016-01-01

    Evaluering af, om de politiske intentioner med indsats mod social dumping i Københavns Kommune er blevet indfriet......Evaluering af, om de politiske intentioner med indsats mod social dumping i Københavns Kommune er blevet indfriet...

  12. Conceptual design of the 7 megawatt Mod-5B wind turbine generator

    Science.gov (United States)

    Douglas, R. R.

    1982-01-01

    Similar to MOD-2, the MOD-5B wind turbine generator system is designed for the sole purpose of providing electrical power for distribution by a major utility network. The objectives of the MOD-2 and MOD-5B programs are essentially identical with one important exception; the cost-of-electricity (COE) target is reduced from 4 cent/Kwhr on MOD-2 to 3 cent/Kwhr on MOD-5B, based on mid 1977 dollars and large quantity production. The MOD-5B concept studies and eventual concept selection confirmed that the program COE targets could not only be achieved but substantially bettered. Starting from the established MOD-2 technology as a base, this achievement resulted from a combination of concept changes, size changes, and design refinements. The result of this effort is a wind turbine system that can compete with conventional power generation over significant geographical areas, increasing commercial market potential by an order of magnitude.

  13. Improved guidelines for RELAP4/MOD6 reflood calculations

    International Nuclear Information System (INIS)

    Chen, T.H.; Fletcher, C.D.

    1980-01-01

    Computer simulations were performed for an extensive selection of forced- and gravity-feed reflood experiments. This effort was a portion of the assessment procedure for the RELAP4/MOD6 thermal hydraulic computer code. A common set of guidelines, based on recommendations from the code developers, was used in determining the model and user-selected input options for each calculation. The comparison of code-calculated and experimental data was then used to assess the capability of the RELAP4/MOD6 code to model the reflood phenomena. As a result of the assessment, the guidelines for determining the user-selected input options were improved

  14. Development and application of STCP Mod 1.1

    International Nuclear Information System (INIS)

    Hu Zhiyi

    1990-01-01

    A state-of-the-art Source Term Code Package-STCP Mod 1.1 is used for assessing the release of radioactive materials to the environment in severe reactor accidents. Its structure and function, and its installation and development on CYBER computer in China are introduced. Through calculations and analyses for 4 selected severe accident sequences from ZION Nuclear Power Plant of the U.S., it shows that the developed STCP Mod 1.1 is suitable to calculate varios scenarios as long as the selections of the model and parameters are reasonable

  15. Developmental assessment of RELAP5/MOD3 using the semiscale natural circulation tests

    International Nuclear Information System (INIS)

    Carlson, K.E.

    1990-01-01

    A code development effort creating RELAP5/MOD3 from RELAP5/MOD2 has been completed. Upon completion, a developmental assessment task was performed. One of the problems used for the developmental assessment was the Semiscale Natural Circulation Test. Calculated results from RELAP5/MOD3 are compared to measured data and previously calculated results from RELAP5/MOD2. 10 refs., 6 figs., 1 tab

  16. Mod 1 ICS TI Report: ICS Conversion of a 140% HPGe Detector

    Energy Technology Data Exchange (ETDEWEB)

    Bounds, John Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-07-05

    This report evaluates the Mod 1 ICS, an electrically cooled 140% HPGe detector. It is a custom version of the ORTEC Integrated Cooling System (ICS) modified to make it more practical for us to use in the field. Performance and operating characteristics of the Mod 1 ICS are documented, noting both pros and cons. The Mod 1 ICS is deemed a success. Recommendations for a Mod 2 ICS, a true field prototype, are provided.

  17. Application of a qPCR assay in the investigation of susceptibility to malaria infection of the M and S molecular forms of An. gambiae s.s. in Cameroon.

    Directory of Open Access Journals (Sweden)

    Anne Boissière

    Full Text Available Plasmodium falciparum is the causative agent of malaria, a disease that kills almost one million persons each year, mainly in sub-Saharan Africa. P. falciparum is transmitted to the human host by the bite of an Anopheles female mosquito, and Anopheles gambiae sensus stricto is the most tremendous malaria vector in Africa, widespread throughout the afro-tropical belt. An. gambiae s.s. is subdivided into two distinct molecular forms, namely M and S forms. The two molecular forms are morphologically identical but they are distinct genetically, and differ by their distribution and their ecological preferences. The epidemiological importance of the two molecular forms in malaria transmission has been poorly investigated so far and gave distinct results in different areas. We have developed a real-time quantitative PCR (qPCR assay, and used it to detect P. falciparum at the oocyst stage in wild An. gambiae s.s. mosquitoes experimentally infected with natural isolates of parasites. Mosquitoes were collected at immature stages in sympatric and allopatric breeding sites and further infected at the adult stage. We next measured the infection prevalence and intensity in female mosquitoes using the qPCR assay and correlated the infection success with the mosquito molecular forms. Our results revealed different prevalence of infection between the M and S molecular forms of An. gambiae s.s. in Cameroon, for both sympatric and allopatric populations of mosquitoes. However, no difference in the infection intensity was observed. Thus, the distribution of the molecular forms of An. gambiae s.s. may impact on the malaria epidemiology, and it will be important to monitor the efficiency of malaria control interventions on the two M and S forms.

  18. Steady-state simulations of a 30-tube once-through steam generator with the RELAP5/MOD3 and RELAP5/MOD2 computer codes

    International Nuclear Information System (INIS)

    Hassan, Y.A.; Salim, P.

    1991-01-01

    This paper reports on a steady-state analysis of a 30-tube once-through steam generator that has been performed on the RELAPS/MOD3 and RELAPS/MOD2 computer codes for 100, 75, and 65% loads. Results obtained are compared with experimental data. The RELAP5/MOD3 results for the test facility generally agree reasonably well with the data for the primary-side temperature profiles. The secondary-side temperature profile predicted by RELAP5/MOD3 at 75 and 65% loads agrees fairly well with the data and is better than the RELAP5/MOD2 results. However, the RELAP5/MOD3 calculated secondary-side temperature profile does not compare well with the 100% load data

  19. MOD control center automated information systems security evolution

    Science.gov (United States)

    Owen, Rich

    1991-01-01

    The role of the technology infusion process in future Control Center Automated Information Systems (AIS) is highlighted. The following subject areas are presented in the form of the viewgraphs: goals, background, threat, MOD's AISS program, TQM, SDLC integration, payback, future challenges, and bottom line.

  20. Vold mod førskolebørn

    DEFF Research Database (Denmark)

    Oldrup, Helene; Lindstrøm, Maia; Korzen, Sara

    Denne rapport handler om praksis og barrierer for opsporing af og underretning om vold mod førskolebørn. Rapporten er baseret på 22 kvalitative interviews med fagfolk inden for dagpasning, sundhedsvæsen og det sociale system. Undersøgelsen viser bl.a., at en del af fagfolkene ofte tøver med at un...

  1. Power oscillation of the Mod-0 wind turbine

    Science.gov (United States)

    Seidel, R. C.

    1978-01-01

    The Mod-0 power has noise components with varying frequency patterns. Magnitudes reach more than forty percent power at the frequency of twice per rotor revolution. Analysis of a simple torsional model of the power train predicts less than half the observed magnitude and does not explain the shifting frequencies of the noise patterns.

  2. NetMOD Version 2.0 Mathematical Framework

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Young, Christopher J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Chael, Eric P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    NetMOD ( Net work M onitoring for O ptimal D etection) is a Java-based software package for conducting simulation of seismic, hydroacoustic and infrasonic networks. Network simulations have long been used to study network resilience to station outages and to determine where additional stations are needed to reduce monitoring thresholds. NetMOD makes use of geophysical models to determine the source characteristics, signal attenuation along the path between the source and station, and the performance and noise properties of the station. These geophysical models are combined to simulate the relative amplitudes of signal and noise that are observed at each of the stations. From these signal-to-noise ratios (SNR), the probabilities of signal detection at each station and event detection across the network of stations can be computed given a detection threshold. The purpose of this document is to clearly and comprehensively present the mathematical framework used by NetMOD, the software package developed by Sandia National Laboratories to assess the monitoring capability of ground-based sensor networks. Many of the NetMOD equations used for simulations are inherited from the NetSim network capability assessment package developed in the late 1980s by SAIC (Sereno et al., 1990).

  3. Dimensionering af stålrammebygninger mod kipning

    DEFF Research Database (Denmark)

    Borchersen, E.; Frederiksen, J.O.; Skov, K.

    Rapporten beskriver en metode til dimensionering af stålrammebygninger mod kipning. Metoden er baseret dels på elasticitetsteoretiske overvejelser, dels på forsøg udført med 3-charniers stålrammmer i fuld skala....

  4. Countercurrent flow limitation model for RELAP5/MOD3

    International Nuclear Information System (INIS)

    Riemke, R.A.

    1991-01-01

    This paper reports on a countercurrent flow limitation model incorporated into the RELAP5/MOD3 system transient analysis code. The model is implemented in a manner similar to the RELAP5 chocking model. Simulations using air/water flooding test problem demonstrate the ability of the code to significantly improve its comparison to data when a flooding correlation is used

  5. Insecticidal and sterilizing effect of Olyset Duo®, a permethrin and pyriproxyfen mixture net against pyrethroid-susceptible and -resistant strains of Anopheles gambiae s.s.: a release-recapture assay in experimental huts

    Directory of Open Access Journals (Sweden)

    Djènontin Armel

    2015-01-01

    Full Text Available In the context of the widespread distribution of pyrethroid resistance among malaria vectors, we did a release-recapture trial in experimental huts to investigate the insecticidal and sterilizing effects of a novel long-lasting net (LN, Olyset® Duo, incorporating a mixture of permethrin (PER and the insect growth regulator (IGR, pyri-proxyfen (PPF. An LN containing PPF alone and a classic Olyset® Net were tested in parallel as positive controls. The effect of progressive number of holes (6, 30, or 150 that may accrue in nets over time was simulated. We used two laboratory Anopheles gambiae s.s. strains: the susceptible Kisumu strain and the pyrethroid-resistant VK-Per strain having solely kdr as resistance mechanism. The effect of these nets on the reproductive success of blood-fed females that survived the different LNs conditions was recorded. Regardless of the mosquito strain, the LNs containing PPF alone with as many as 30 holes drastically reduced the number of eggs laid by females succeeding in feeding, i.e. fecundity by 98% and egg hatching rate (fertility by 93% relative to untreated control net. Very few of the resistant females blood fed and survived under the Olyset® Duo with similar number of holes (up to 30 but of these few, the inhibition of reproductive success was 100%. There was no evidence that the Olyset® Duo LN with 150 holes impacted fecundity or fertility of the resistant colony. The efficacy of Olyset® Duo is encouraging and clearly illustrates that this new net might be a promising tool for malaria transmission control and resistance management.

  6. Insecticidal and sterilizing effect of Olyset Duo®, a permethrin and pyriproxyfen mixture net against pyrethroid-susceptible and -resistant strains of Anopheles gambiae s.s.: a release-recapture assay in experimental huts.

    Science.gov (United States)

    Djènontin, Armel; Ahoua Alou, Ludovic P; Koffi, Alphonsine; Zogo, Barnabas; Duarte, Elves; N'Guessan, Raphael; Moiroux, Nicolas; Pennetier, Cédric

    2015-01-01

    In the context of the widespread distribution of pyrethroid resistance among malaria vectors, we did a release-recapture trial in experimental huts to investigate the insecticidal and sterilizing effects of a novel long-lasting net (LN), Olyset® Duo, incorporating a mixture of permethrin (PER) and the insect growth regulator (IGR), pyri-proxyfen (PPF). An LN containing PPF alone and a classic Olyset® Net were tested in parallel as positive controls. The effect of progressive number of holes (6, 30, or 150) that may accrue in nets over time was simulated. We used two laboratory Anopheles gambiae s.s. strains: the susceptible Kisumu strain and the pyrethroid-resistant VK-Per strain having solely kdr as resistance mechanism. The effect of these nets on the reproductive success of blood-fed females that survived the different LNs conditions was recorded. Regardless of the mosquito strain, the LNs containing PPF alone with as many as 30 holes drastically reduced the number of eggs laid by females succeeding in feeding, i.e. fecundity by 98% and egg hatching rate (fertility) by 93% relative to untreated control net. Very few of the resistant females blood fed and survived under the Olyset® Duo with similar number of holes (up to 30) but of these few, the inhibition of reproductive success was 100%. There was no evidence that the Olyset® Duo LN with 150 holes impacted fecundity or fertility of the resistant colony. The efficacy of Olyset® Duo is encouraging and clearly illustrates that this new net might be a promising tool for malaria transmission control and resistance management. © A. Djènontin et al., published by EDP Sciences, 2015.

  7. Apo and ligand-bound structures of ModA from the archaeon Methanosarcina acetivorans

    International Nuclear Information System (INIS)

    Chan, Sum; Giuroiu, Iulia; Chernishof, Irina; Sawaya, Michael R.; Chiang, Janet; Gunsalus, Robert P.; Arbing, Mark A.; Perry, L. Jeanne

    2010-01-01

    Crystal structures of ModA from M. acetivorans in the apo and ligand-bound conformations confirm domain rotation upon ligand binding. The trace-element oxyanion molybdate, which is required for the growth of many bacterial and archaeal species, is transported into the cell by an ATP-binding cassette (ABC) transporter superfamily uptake system called ModABC. ModABC consists of the ModA periplasmic solute-binding protein, the integral membrane-transport protein ModB and the ATP-binding and hydrolysis cassette protein ModC. In this study, X-ray crystal structures of ModA from the archaeon Methanosarcina acetivorans (MaModA) have been determined in the apoprotein conformation at 1.95 and 1.69 Å resolution and in the molybdate-bound conformation at 2.25 and 2.45 Å resolution. The overall domain structure of MaModA is similar to other ModA proteins in that it has a bilobal structure in which two mixed α/β domains are linked by a hinge region. The apo MaModA is the first unliganded archaeal ModA structure to be determined: it exhibits a deep cleft between the two domains and confirms that upon binding ligand one domain is rotated towards the other by a hinge-bending motion, which is consistent with the ‘Venus flytrap’ model seen for bacterial-type periplasmic binding proteins. In contrast to the bacterial ModA structures, which have tetrahedral coordination of their metal substrates, molybdate-bound MaModA employs octahedral coordination of its substrate like other archaeal ModA proteins

  8. Simulation, modélisation et décision en pratique

    CERN Document Server

    Rennard, Jean-Philippe; Duymedjian, Raffi

    2009-01-01

    Avec l'explosion de la puissance informatique, le grand public dispose désormais d'outils aptes à résoudre des problèmes complexes, auparavant hors de portée des non-spécialistes. Le tableur notamment est particulièrement adapté à la modélisation et à la simulation de nombre de problèmes quotidiens de décision. En parallèle, le décideur est confronté à un environnement en évolution rapide, où la décision éclairée est une condition de succès. Face à une avalanche de données, il est le plus souvent amené à sélection intuitivement celles qui sont susceptibles de l'aide à anticiper les conséquences de ses décisions. Cet ouvrage se propose de présenter les principale méthodes d'aide à la décision et d'en montrer la mise en oeuvre avec le tableur. D'une difficulté progressive, l'ouvrage introduit à la modélisation e à la simulation pour la décision avant de présenter les outils dédiés à différents types de problèmes (prévision, optimisation, théorie des jeux, arbres d...

  9. Apo and ligand-bound structures of ModA from the archaeon Methanosarcina acetivorans.

    Science.gov (United States)

    Chan, Sum; Giuroiu, Iulia; Chernishof, Irina; Sawaya, Michael R; Chiang, Janet; Gunsalus, Robert P; Arbing, Mark A; Perry, L Jeanne

    2010-03-01

    The trace-element oxyanion molybdate, which is required for the growth of many bacterial and archaeal species, is transported into the cell by an ATP-binding cassette (ABC) transporter superfamily uptake system called ModABC. ModABC consists of the ModA periplasmic solute-binding protein, the integral membrane-transport protein ModB and the ATP-binding and hydrolysis cassette protein ModC. In this study, X-ray crystal structures of ModA from the archaeon Methanosarcina acetivorans (MaModA) have been determined in the apoprotein conformation at 1.95 and 1.69 A resolution and in the molybdate-bound conformation at 2.25 and 2.45 A resolution. The overall domain structure of MaModA is similar to other ModA proteins in that it has a bilobal structure in which two mixed alpha/beta domains are linked by a hinge region. The apo MaModA is the first unliganded archaeal ModA structure to be determined: it exhibits a deep cleft between the two domains and confirms that upon binding ligand one domain is rotated towards the other by a hinge-bending motion, which is consistent with the 'Venus flytrap' model seen for bacterial-type periplasmic binding proteins. In contrast to the bacterial ModA structures, which have tetrahedral coordination of their metal substrates, molybdate-bound MaModA employs octahedral coordination of its substrate like other archaeal ModA proteins.

  10. Irradiation hardening of Mod.9Cr-1Mo steel

    International Nuclear Information System (INIS)

    Ryu, Woo-Seog; Kim, Sung-Ho; Choo, Kee-Nam; Kim, Do-Sik

    2009-01-01

    An irradiation test of Mod.9Cr-1Mo steel was carried out in the OR5 test hole of HANARO of a 30 MW thermal power at 390±10degC up to a fast neutron fluence of 4.4x10 19 (n/cm 2 ) (E > 1.0 MeV). The dpa of the irradiated specimens was evaluated to be 0.034 - 0.07. Tensile and impact tests of the irradiated Mod.9Cr-1Mo were done in the hot cell of the IMEF. The change of the tensile strength by irradiation was similar to the change of the yield strength. The increase of the yield and tensile strengths was up to 18% and 10% respectively. The elongation reduction of the weldment was up to 65%. (author)

  11. Peer review of RELAP5/MOD3 documentation

    International Nuclear Information System (INIS)

    Craddick, W.G.

    1993-01-01

    A peer review was performed on a portion of the documentation of the RELAP5/MOD3 computer code. The review was performed in two phases. The first phase was a review of Volume 3, Developmental Assessment problems, and Volume 4, Models and Correlations. The reviewers for this phase were Dr. Peter Griffith, Dr. Yassin Hassan, Dr. Gerald S. Lellouche, Dr. Marino di Marzo and Mr. Mark Wendel. The reviewers recommended a number of improvements, including using a frozen version of the code for assessment guided by a validation plan, better justification for flow regime maps and extension of models beyond their data base. The second phase was a review of Volume 6, Quality Assurance of Numerical Techniques in RELAP5/MOD3. The reviewers for the second phase were Mr. Mark Wendel and Dr. Paul T. Williams. Recommendations included correction of numerous grammatical and typographical errors and better justification for the use of Lax's Equivalence Theorem

  12. Perspectives d’avenir du modèle autrichien

    OpenAIRE

    Neisser, Heinrich

    2018-01-01

    Plusieurs de ceux qui m’ont précédé ont déjà décrit des éléments de ce modèle autrichien qui suscite beaucoup d’intérêt à l’étranger, mais qui – et cela aussi a été signalé un certain nombre de fois – ne peut pas être transposé dans sa totalité à d’autres pays. De tels modèles concrets pour la solution de conflits sociaux naissent à partir d’un certain contexte historique. Ils se développent de manière pragmatique, c’est-à-dire pour résoudre, le mieux possible, des problèmes qui se posent à u...

  13. RELAP 4/MOD 6 boiling water nodalization study

    International Nuclear Information System (INIS)

    Sonneck, G.; Pfau, H.

    1985-09-01

    The risk of nuclear steam supply systems is dominated by the core melt accidents. The first step to a realistic assessment of these sequences is the successful prediction of a loss of coolant event in a test loop. One of the codes for that is RELAP 4/MOD 6 and one of the important options in this code is the nodalization. The base of this work is the test LOCA No. 1 FIX II in Studsvik (Sweden) which also served as the OECD International Standard Problem 15. This report discusses the influence of different nodalizations, of different distributions of pressure, water and structural heat as well as of different bubble rise options, break flow coefficients, and heat transfer time steps. The most important result is that a simple RELAP 4/MOD6 model with less than 10 volumes is able to predict an experiment as LOCA No. 1 in FIX II successfully using only a fraction of the usual computing time. (Author)

  14. SCDAP/RELAP5/MOD3 code development

    International Nuclear Information System (INIS)

    Allison, C.M.; Siefken, J.L.; Coryell, E.W.

    1992-01-01

    The SCOAP/RELAP5/MOD3 computer code is designed to describe the overall reactor coolant system (RCS) thermal-hydraulic response, core damage progression, and fission product release and transport during severe accidents. The code is being developed at the Idaho National Engineering Laboratory (INEL) under the primary sponsorship of the Office of Nuclear Regulatory Research of the US Nuclear Regulatory Commission (NRC). Code development activities are currently focused on three main areas - (a) code usability, (b) early phase melt progression model improvements, and (c) advanced reactor thermal-hydraulic model extensions. This paper describes the first two activities. A companion paper describes the advanced reactor model improvements being performed under RELAP5/MOD3 funding

  15. Assessment of ICRF Antenna Performance in Alcator C-Mod

    International Nuclear Information System (INIS)

    Schilling, G.; Wukitch, S.J.; Lin, Y.; Basse, N.; Bonoli, P.T.; Edlund, E.; Lin, L.; Parisot, A.; Porkolab, M.

    2004-01-01

    The Alcator C-Mod has presented a challenge to install high-power ICRF antennas in a tight space. Modifications have been made to the antenna plasma-facing surfaces and the internal current-carrying structure in order to overcome performance limitations. At the present time, the antennas have exceeded 5 MW into plasma with heating phasing, up to 2.7 MW with current-drive phasing, with good efficiency and no deleterious effects

  16. RELAP4/MOD-5-CEA pump coastdown experiment simulation

    International Nuclear Information System (INIS)

    Borges, R.C.; Freitas, R.L.

    1988-07-01

    Since is important the theoretical-experimental comparison to evaluate the computer codes, these paper presents the simulation with RELAP4/MOD5 Code of a loss of power energy in the pump of the ''Circuito Experimental de Agua-CEA''. From the results attained, the existing models in the Code showed to be very satisfatory quantitative and qualitative behavior of the attained experimental results. (author) [pt

  17. C-Mod Collaboration Informal Technical Progress Report

    International Nuclear Information System (INIS)

    Kenneth W. Gentle

    2007-01-01

    The aims of the collaboration have not changed. A specific list of tasks was agreed upon during the Fall of 2006 in preparation for the 2007 C-Mod campaign by Earl Marmar, Head of the Alcator Project, Kenneth Gentle, Principal Investigator, and William Rowan, Collaboration Coordinator with the facilitation of Adam Rosenberg (DOE grant monitor for the collaboration). The activities follow the list of tasks and are discussed in this progress report

  18. Blow.MOD2: a program for blowdown transient calculations

    International Nuclear Information System (INIS)

    Doval, A.

    1990-01-01

    The BLOW.MOD2 program has been developed to calculate the blowdown phase in a pressurized vessel after a break/valve is opened. It is a one volume model where break height and flow area are specified. Moody critical flow model was adopted under saturation conditions for flow calculation through the break. Heat transfer from structures and internals have been taken into account. Long term depressurization results and a more complex model are compared satisfactorily. (Author)

  19. Quality Assurance Procedures for ModCat Database Code Files

    Energy Technology Data Exchange (ETDEWEB)

    Siciliano, Edward R.; Devanathan, Ram; Guillen, Zoe C.; Kouzes, Richard T.; Schweppe, John E.

    2014-04-01

    The Quality Assurance procedures used for the initial phase of the Model Catalog Project were developed to attain two objectives, referred to as “basic functionality” and “visualization.” To ensure the Monte Carlo N-Particle model input files posted into the ModCat database meet those goals, all models considered as candidates for the database are tested, revised, and re-tested.

  20. Nonaxisymmetric field effects on Alcator C-Mod

    International Nuclear Information System (INIS)

    Wolfe, S.M.; Hutchinson, I.H.; Granetz, R.S.; Rice, J.; Hubbard, A.; Lynn, A.; Phillips, P.; Hender, T.C.; Howell, D.F.; La Haye, R.J.; Scoville, J.T.

    2005-01-01

    A set of external coils (A-coils) capable of producing nonaxisymmetric, predominantly n=1, fields with different toroidal phase and a range of poloidal mode m spectra has been used to determine the threshold amplitude for mode locking over a range of plasma parameters in Alcator C-Mod [I. H. Hutchinson, R. Boivin, F. Bombarda, P. Bonoli, S. Fairfax, C. Fiore, J. Goetz, S. Golovato, R. Granetz, M. Greenwald et al., Phys. Plasmas 1, 1511 (1994)]. The threshold perturbations and parametric scalings, expressed in terms of (B 21 /B T ), are similar to those observed on larger, lower field devices. The threshold is roughly linear in density, with typical magnitudes of order 10 -4 . This result implies that locked modes should not be significantly more problematic for the International Thermonuclear Experimental Reactor [I. P. B. Editors, Nucl. Fusion 39, 2286 (1999)] than for existing devices. Coordinated nondimensional identity experiments on the Joint European Torus [Fusion Technol. 11, 13 (1987)], DIII-D [Fusion Technol. 8, 441 (1985)], and C-Mod, with matching applied mode spectra, have been carried out to determine more definitively the field and size scalings. Locked modes on C-Mod are observed to result in braking of core toroidal rotation, modification of sawtooth activity, and significant reduction in energy and particle confinement, frequently leading to disruptions. Intrinsic error fields inferred from the threshold studies are found to be consistent in amplitude and phase with a comprehensive model of the sources of field errors based on 'as-built' coil and bus-work details and coil imperfections inferred from measurements using in situ magnetic diagnostics on dedicated test pulses. Use of the A-coils to largely cancel the 2/1 component of the intrinsic nonaxisymmetric field has led to expansion of the accessible operating space in C-Mod, including operation up to 2 MA plasma current at 8 T

  1. Recueil de modèles aléatoires

    CERN Document Server

    Chafai, Djalil

    2016-01-01

    Ce recueil puise sa source dans les cours de master de mathématiques appliquées et de préparation à l’épreuve de modélisation de l’agrégation de mathématiques. Le parti pris de cet ouvrage est de polariser la rédaction par les modèles plutôt que par les outils, et de consacrer chaque chapitre à un modèle. Le premier public visé est celui des enseignants-chercheurs en probabilités, débutants ou confirmés. De nombreux chapitres peuvent également bénéficier directement à des étudiants de master ou préparant l’agrégation. Collected Stochastic Models This collection was inspired by applied mathematics Master classes in stochastic modeling. The focus is on models rather than on tools, and each chapter is devoted to a specific model. Though the book is primarily intended for academics in the field of probability theory, beginners and experienced researchers alike, many chapters will also benefit students preparing to pursue their Master degree in mathematics. .

  2. MOD-RTG multicouple test results and mission readiness

    International Nuclear Information System (INIS)

    Hartman, R.F.; Kelly, C.E.

    1993-01-01

    MOD-RTG represents the design configuration for the next generation of Radioisotope Thermoelectric Generators (RTG), aimed at improving specific power and efficiency over current General Purpose Heat Source Radioisotope Thermoelectric Generators (GPHS-RTGs). The modular RTG reference design has been described in previous papers (Hartman 1988). The multicouple is a key element required for the successful development of the modular RTG. The multicouple is a high voltage, thermoelectric device employing a close packed, glass bonded thermopile array of twenty thermoelectric couples, connected in a series circuit. The multicouple is designed to operate at a 1270 K hot junction temperature and a 570 K cold junction temperature, yielding a power output of approximately 2.1 watts at 3.5 volts at beginning of life. The objectives of the MOD-RTG program are focused on establishing a multicouple life test data base and life prediction capability which will permit, with reasonable margin, a projected multicouple life of greater than eight (8) years. This paper summarizes the current status of multicouple life testing and performance modeling and the level of technology readiness needed to demonstrate mission readiness for MOD-RTG

  3. Rotation and transport in Alcator C-Mod ITB plasmas

    Science.gov (United States)

    Fiore, C. L.; Rice, J. E.; Podpaly, Y.; Bespamyatnov, I. O.; Rowan, W. L.; Hughes, J. W.; Reinke, M.

    2010-06-01

    Internal transport barriers (ITBs) are seen under a number of conditions in Alcator C-Mod plasmas. Most typically, radio frequency power in the ion cyclotron range of frequencies (ICRFs) is injected with the second harmonic of the resonant frequency for minority hydrogen ions positioned off-axis at r/a > 0.5 to initiate the ITBs. They can also arise spontaneously in ohmic H-mode plasmas. These ITBs typically persist tens of energy confinement times until the plasma terminates in radiative collapse or a disruption occurs. All C-Mod core barriers exhibit strongly peaked density and pressure profiles, static or peaking temperature profiles, peaking impurity density profiles and thermal transport coefficients that approach neoclassical values in the core. The strongly co-current intrinsic central plasma rotation that is observed following the H-mode transition has a profile that is peaked in the centre of the plasma and decreases towards the edge if the ICRF power deposition is in the plasma centre. When the ICRF resonance is placed off-axis, the rotation develops a well in the core region. The central rotation continues to decrease as long as the central density peaks when an ITB develops. This rotation profile is flat in the centre (0 ITB density profile is observed (0.5 ITB foot that is sufficiently large to stabilize ion temperature gradient instabilities that dominate transport in C-Mod high density plasmas.

  4. TRAC-PF1/MOD1 assessment at Los Alamos

    International Nuclear Information System (INIS)

    Knight, T.D.

    1984-01-01

    The Los Alamos National Laboratory is developing the Transient Reactor Analysis Code (TRAC) to provide an advanced best-estimate predictive capability for the analysis of postulated accidents in pressurized water reactors (PWRs). Over the past several years, four distinct versions of the code have been released; each new version introduced improvements to the existing models and numerics and added new models to extend the applications of the code. The first goal of the code was to analyze large-break loss-of-coolant accidents (LOCAs), and the TRAC-P1A and TRAC-PD2 codes primarily addressed the large-break LOCA. (The TRAC-PD2/MOD1 code is essentially the same as the TRAC-PD2 code but it also includes a released set of error corrections.) The TRAC-PF1 code contained major changes to the models and trips and to the numerical methods. These modifications enhanced the computational speed of the code and improved the application to small-break LOCAs. The TRAC-PF1/MOD1 code, the latest released version, added improved steam-generator modeling, a turbine component, and a control system together with modified constitutive relations to model the balance of plant on the secondary side and to extend the applications to non-LOCA transients. The TRAC-PF1/MOD1 code also contains reasonably general reactor-kinetics modeling to facilitate the simulation of transients with delayed scram or without scram. 13 references, 24 figures

  5. Les enjeux du modèle standard

    CERN Document Server

    CERN. Geneva

    2008-01-01

    Toute la matière visible dans l'Univers est décrite par le « Modèle Standard ». Selon cette théorie, la matière est constituée d'atomes, qui contiennent des électrons orbitant autour de noyaux, dont les composants fondamentaux sont les quarks. Quatre forces fondamentales agissent entre ces particules élémentaires : les forces électromagnétique est gravitationnelle, et les interactions nucléaires forte et faible. La description fournie par le Modèle Standard de ces particules et de leurs interactions est en parfait accord avec les expériences. Néanmoins, des questions fondamentales restent sans réponse jusqu'à maintenant : d'où vient la masse des particules ? Pourquoi y a-t-il tant de types de particules ? Existe-t-il une théorie unifiée de toutes les interactions ? Quelle est la nature de la matière cachée prédite par les astrophysiciens ? Le LHC au CERN donnera des éléments de réponse à ces questions au-delà du Modèle Standard.

  6. Prevalence and Antibiotic susceptibility pattern of Panton-Valentine ...

    African Journals Online (AJOL)

    Staphylococcal cassette chromosome mec typing by two standard multiplex PCR assay, revealed an uncharacterized resistance element. Overall antibiotic susceptibility pattern showed relatively high degree of susceptibility,however 1 isolate demostrated multidrug resistant pattern, 37(74.0%)resistant to only penicillin, 5 to ...

  7. Modding a free and open source software video game: "Play testing is hard work"

    Directory of Open Access Journals (Sweden)

    Giacomo Poderi

    2014-03-01

    Full Text Available Video game modding is a form of fan productivity in contemporary participatory culture. We see modding as an important way in which modders experience and conceptualize their work. By focusing on modding in a free and open source software video game, we analyze the practice of modding and the way it changes modders' relationship with their object of interest. The modders' involvement is not always associated with fun and creativity. Indeed, activities such as play testing often undermine these dimensions of modding. We present a case study of modding that is based on ethnographic research done for The Battle for Wesnoth, a free and open source software strategy video game entirely developed by a community of volunteers.

  8. MOD-2 wind turbine system concept and preliminary design report. Volume 2: Detailed report

    Science.gov (United States)

    1979-01-01

    The configuration development of the MOD-2 wind turbine system (WTS) is documented. The MOD-2 WTS project is a continuation of DOE programs to develop and achieve early commercialization of wind energy. The MOD-2 is design optimized for commercial production rates which, in multiunit installations, will be integrated into a utility power grid and achieve a cost of electricity at less than four cents per kilowatt hour.

  9. RELAP5/MOD1-EUR evaluation. Comparison with the INEL original version

    International Nuclear Information System (INIS)

    Mazzantini, O.A.

    1990-01-01

    In this work, the values calculated from two versions of the RELAP5/MOD1 code are compared with those measured in different tests. The first version of RELAP5 is the cycle 19 of the original version of INEL (RELAP5/MOD1-INEL) and the second version improved by EURATOM (RELAP5/MOD1-EUR) which was transferred to ENACE through agreements made with SIEMENS/KWU. (Author) [es

  10. Binding and Oligomerization of Modified and Native Bt Toxins in Resistant and Susceptible Pink Bollworm.

    Directory of Open Access Journals (Sweden)

    Josue Ocelotl

    Full Text Available Insecticidal proteins from Bacillus thuringiensis (Bt are used extensively in sprays and transgenic crops for pest control, but their efficacy is reduced when pests evolve resistance. Better understanding of the mode of action of Bt toxins and the mechanisms of insect resistance is needed to enhance the durability of these important alternatives to conventional insecticides. Mode of action models agree that binding of Bt toxins to midgut proteins such as cadherin is essential for toxicity, but some details remain unresolved, such as the role of toxin oligomers. In this study, we evaluated how Bt toxin Cry1Ac and its genetically engineered counterpart Cry1AcMod interact with brush border membrane vesicles (BBMV from resistant and susceptible larvae of Pectinophora gossypiella (pink bollworm, a global pest of cotton. Compared with Cry1Ac, Cry1AcMod lacks 56 amino acids at the amino-terminus including helix α-1; previous work showed that Cry1AcMod formed oligomers in vitro without cadherin and killed P. gossypiella larvae harboring cadherin mutations linked with >1000-fold resistance to Cry1Ac. Here we found that resistance to Cry1Ac was associated with reduced oligomer formation and insertion. In contrast, Cry1AcMod formed oligomers in BBMV from resistant larvae. These results confirm the role of cadherin in oligomerization of Cry1Ac in susceptible larvae and imply that forming oligomers without cadherin promotes toxicity of Cry1AcMod against resistant P. gossypiella larvae that have cadherin mutations.

  11. Code development and analysis program. RELAP4/MOD7 (Version 2): user's manual

    International Nuclear Information System (INIS)

    1978-08-01

    This manual describes RELAP4/MOD7 (Version 2), which is the latest version of the RELAP4 LPWR blowdown code. Version 2 is a precursor to the final version of RELAP4/MOD7, which will address LPWR LOCA analysis in integral fashion (i.e., blowdown, refill, and reflood in continuous fashion). This manual describes the new code models and provides application information required to utilize the code. It must be used in conjunction with the RELAP4/MOD5 User's Manual (ANCR-NUREG-1335, dated September 1976), and the RELAP4/MOD6 User's Manual

  12. Cost-effectiveness analysis of microscopic observation drug susceptibility test versus Xpert MTB/Rif test for diagnosis of pulmonary tuberculosis in HIV patients in Uganda.

    Science.gov (United States)

    Walusimbi, Simon; Kwesiga, Brendan; Rodrigues, Rashmi; Haile, Melles; de Costa, Ayesha; Bogg, Lennart; Katamba, Achilles

    2016-10-10

    Microscopic Observation Drug Susceptibility (MODS) and Xpert MTB/Rif (Xpert) are highly sensitive tests for diagnosis of pulmonary tuberculosis (PTB). This study evaluated the cost effectiveness of utilizing MODS versus Xpert for diagnosis of active pulmonary TB in HIV infected patients in Uganda. A decision analysis model comparing MODS versus Xpert for TB diagnosis was used. Costs were estimated by measuring and valuing relevant resources required to perform the MODS and Xpert tests. Diagnostic accuracy data of the tests were obtained from systematic reviews involving HIV infected patients. We calculated base values for unit costs and varied several assumptions to obtain the range estimates. Cost effectiveness was expressed as costs per TB patient diagnosed for each of the two diagnostic strategies. Base case analysis was performed using the base estimates for unit cost and diagnostic accuracy of the tests. Sensitivity analysis was performed using a range of value estimates for resources, prevalence, number of tests and diagnostic accuracy. The unit cost of MODS was US$ 6.53 versus US$ 12.41 of Xpert. Consumables accounted for 59 % (US$ 3.84 of 6.53) of the unit cost for MODS and 84 % (US$10.37 of 12.41) of the unit cost for Xpert. The cost effectiveness ratio of the algorithm using MODS was US$ 34 per TB patient diagnosed compared to US$ 71 of the algorithm using Xpert. The algorithm using MODS was more cost-effective compared to the algorithm using Xpert for a wide range of different values of accuracy, cost and TB prevalence. The cost (threshold value), where the algorithm using Xpert was optimal over the algorithm using MODS was US$ 5.92. MODS versus Xpert was more cost-effective for the diagnosis of PTB among HIV patients in our setting. Efforts to scale-up MODS therefore need to be explored. However, since other non-economic factors may still favour the use of Xpert, the current cost of the Xpert cartridge still needs to be reduced further by more than

  13. La Sémantique des Possibles Argumentatifs : un modèle de description-construction-représentation des significations lexicales

    Directory of Open Access Journals (Sweden)

    Virginie Marie

    2009-12-01

    Full Text Available Cet article se donne pour tâche d’illustrer le modèle théorique de la SPA (Sémantique des Possibles Argumentatifs proposé et développé par GALATANU. Cette théorie se présente comme un modèle de description de la signification lexicale susceptible de rendre compte aussi bien des représentations du monde perçu et « modélisé » par la langue que du « potentiel argumentatif » des mots, potentiel que l’environnement pragmatique de la phase énoncée et/ou l’environnement pragmatique (le contexte du discours peuvent activer, voire renforcer ou, au contraire, affaiblir, voire neutraliser ou même intervertir. Cette théorie s’inscrit dans la filiation de la sémantique argumentative (ANSCOMBRE, DUCROT, 1983, 1995 ; DUCROT, CAREL, 1999 et d’autre part, dans celle de la recherche sur les stéréotypes linguistiques (AMOSSY, 1994 ; KLEIBER, 1999a, b. Dans l’espace de cette communication nous nous proposons de présenter et d’appliquer ce modèle aux notions « francophile, francophilie, francophone, francophonie » qui rendra compte des déploiements argumentatifs en analysant l’évolution des définitions lexicographiques étudiées en termes de noyau et de stéréotypes.

  14. Edge Turbulence Imaging on NSTX and Alcator C-Mod

    International Nuclear Information System (INIS)

    S.J. Zweben; R.A. Maqueda; J.L. Terry; B. Bai; C.J. Boswell; C.E. Bush; D. D'Ippolito; E.D. Fredrickson; M. Greenwald; K. Hallatschek; S. Kaye; B. LaBombard; R. Maingi; J. Myra; W.M. Nevins; B.N. Rogers; D.P. Stotler; J. Wilgen; and X.Q. Xu

    2002-01-01

    Edge turbulence images have been made using an ultra-high speed CCD camera on both NSTX and Alcator C-Mod. In both cases, the D-alpha or HeI (587.6 nm) line emission from localized deuterium or helium gas puffs was viewed along a local magnetic field line near the outer midplane. Fluctuations in this line emission reflect fluctuations in electron density and/or electron temperature through the atomic excitation rates, which can be modeled using the DEGAS-2 code. The 2-D structure of the measured turbulence can be compared with theoretical simulations based on 3-D fluid models

  15. Analyse, Modélisation et Simulation du Mouvement Humain

    OpenAIRE

    Multon , Franck

    2006-01-01

    Comprendre le mouvement humain mobilise des chercheurs de nombreuses disciplines scientifiques : physiologie, biomécanique, neurosciences comportementales, anatomie fonctionnelle, les sciences du sport... Mes travaux s'inscrivent donc dans une démarche pluridisciplinaire d'analyse/synthèse du mouvement humain. Pour mener à bien cette démarche, une première tâche consiste à modéliser et à simuler le système moteur ainsi qu'un ensemble d'hypothèses. L'objectif est de disposer d'une représentati...

  16. Mods and Rockers, Drunken Debutants, and Sozzled Students

    Directory of Open Access Journals (Sweden)

    Bill Thompson

    2012-07-01

    Full Text Available Over the last decade, moral panic theory has affected a paradigm shift in the social construction of deviance and social problems in the United States, without any real debate about its viability. This article raises key questions about this perspective by offering the first ever critique of the seminal case study of British youth subcultures on which the paradigm is based. It argues that when analyzed in the context of contemporary criticism of vandalism, hooliganism, and delinquency, the Mods and Rockers case study never justified Cohen’s original criteria for a moral panic.

  17. Blowdown heat transfer surface in RELAP4/MOD6

    International Nuclear Information System (INIS)

    Nelson, R.A.; Sullivan, L.H.

    1978-01-01

    New heat transfer correlations for both PWR and BWR blowdowns have been implemented in the RELAP4/MOD6 program. The concept of a multidimensional surface is introduced with the heat flux from a given heat transfer correlation or correlations depicted as a mathematical surface that is dependent upon quality, wall superheat, mass flow and pressure. The heat transfer logic has been modularized to facilitate replacing boiling curves for future correlation data comparisons and investigations. To determine the validity of the blowdown surface, comparison has been performed using data from the Semiscale experimental facility. (author)

  18. Conceptual design Alcator C-MOD magnetic systems

    International Nuclear Information System (INIS)

    Schultz, J.H.; Becker, H.; Fertl, K.; Gwinn, D.; Montgomery, D.B.; Pierce, N.T.; Pillsbury, R.D. Jr.; Thome, R.J.

    1986-01-01

    The conceptual designs of the magnetic systems for Alcator C-MOD, a proposed tokamak at M.I.T., are described, including the toroidal magnet, the poloidal field coils and the cryogenic system. The toroidal magnet is constructed from rectangular plates, connected by sliding joints. Toroidal magnet forces are contained by a steel superstructure. Poloidal coil system options are largely or wholly inside the TF magnet, in order to control plasmas with high current, strong shaping, and expanded boundaries. All magnets are cryocooled by the natural circulation of boiling liquid nitrogen. 3 refs., 5 figs

  19. Fatigue impact on Mod-1 wind turbine design

    Science.gov (United States)

    Stahle, C. V., Jr.

    1978-01-01

    Fatigue is a key consideration in the design of a long-life Wind Turbine Generator (WTG) system. This paper discusses the fatigue aspects of the large Mod-1 horizontal-axis WTG design starting with the characterization of the environment and proceeding through the design. Major sources of fatigue loading are discussed and methods of limiting fatigue loading are described. NASTRAN finite element models are used to determine dynamic loading and internal cyclic stresses. Recent developments in determining the allowable fatigue stress consistent with present construction codes are discussed relative to their application to WTG structural design.

  20. Implementation of the thermal-hydraulic transient analysis code RELAP4/MOD5 and MOD6 on the FACOM 230/75 computer system

    International Nuclear Information System (INIS)

    Kohsaka, Atsuo; Ishigai, Takahiro; Kumakura, Toshimasa; Naraoka, Ken-itsu

    1979-03-01

    Development efforts have continued on the extensively used LOCA analysis code RELAP-4, as seen in its history; that is, from the prototype version MOD2 to the latest one MOD6 which is capable of one-through calculations from blowdown to reflood phase of PWR-LOCA. Many improvements and refinements of the models have enlarged the scopes and extents of phenomena to treat. Correspondingly the size of program has increased version to version, and special programming techniques have continuously been introduced to manage the program within limited capacity of core memory. For example, the Dynamic Storage Allocation of MOD5 and the PRELOAD Preprocessor newly incorporated in MOD6 are those designed for the CDC computer with relatively small core size. Described are these programming techniques in detail and experiences on implementation of the codes on FACOM 230/75, together with some results of confirmatory calculations. (author)

  1. BLOW.MOD2: program for a vessel depressurization calculation with the contribution of structures

    International Nuclear Information System (INIS)

    Doval, A.

    1990-01-01

    The BLOW.MOD2 program developed to calculate pressure vessels' depressurization is presented, considering heat contribution of the structures. The results are opposite to those obtained from other more complex numerical models, being the comparison extremely satisfactory. BLOW.MOD2 is a software of the 'Systems Sub-Branch', INVAP S.E. (Author) [es

  2. Moving Past "Hello World": Learning to Mod in an Online Affinity Space

    Science.gov (United States)

    Subramanian, Shree Durga

    2012-01-01

    Game modding has increasingly become a mainstream and "cutting edge" medium to foster a broad range of critical software design and programming practices to learners coming from wide-ranging educational and professional backgrounds. Participatory practices, like game modding, are highly interest-driven and entail intense engagement with…

  3. The mod industries? The industrial logic of non-market game production

    OpenAIRE

    2008-01-01

    Abstract This article seeks to make the relationship between non-market game developers (modders) and the game developer company explicit through game technology. It investigates a particular type of modding, i.e. total conversion mod teams, whose organization can be said to conform to the high-risk, technologically-advanced, capital-intensive, proprietary practice of the developer company. The notion ...

  4. The mod industries? The industrial logic of non-market game production

    NARCIS (Netherlands)

    Nieborg, D.B.; van der Graaf, S.

    2008-01-01

    This article seeks to make the relationship between non-market game developers (modders) and the game developer company explicit through game technology. It investigates a particular type of modding, i.e. total conversion mod teams, whose organization can be said to conform to the high-risk,

  5. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 5

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. Detail drawings of several assemblies and subassemblies are given. This is the fifth book of volume 4.

  6. Mod-2 wind turbine system concept and preliminary design report. Volume 1: Executive summary

    Science.gov (United States)

    1979-01-01

    The configuration development of the MOD-2 wind turbine system is presented. The MOD-2 is design optimized for commercial production rates which, in multi-unit installations, will be integrated into a utility power grid and achieve a cost of electricity at less than 4 cents per kilowatt hour.

  7. The Calgary Biofilm Device: New Technology for Rapid Determination of Antibiotic Susceptibilities of Bacterial Biofilms

    OpenAIRE

    Ceri, H.; Olson, M. E.; Stremick, C.; Read, R. R.; Morck, D.; Buret, A.

    1999-01-01

    Determination of the MIC, based on the activities of antibiotics against planktonic bacteria, is the standard assay for antibiotic susceptibility testing. Adherent bacterial populations (biofilms) present with an innate lack of antibiotic susceptibility not seen in the same bacteria grown as planktonic populations. The Calgary Biofilm Device (CBD) is described as a new technology for the rapid and reproducible assay of biofilm susceptibilities to antibiotics. The CBD produces 96 equivalent bi...

  8. Betænkning om Indsatsen mod ungdomskriminalitet

    DEFF Research Database (Denmark)

    Reimann, Johan; Balvig, Flemming; Bay, Jens

    Kommissionen foretager i betænkningen en samlet gennemgang af indsatsen mod ungdomskriminalitet og præsenterer på grundlag heraf en række forslag til, hvordan indsatsen kan styrkes med henblik på at gøre den så målrettet og virkningsfuld som mulig. Til brug for sine overvejelser har kommissionen...... overvejelser og forslag vedrørende indsatsen mod ungdomskriminalitet omfatter dels den forebyggende indsats, dels reaktionen på kriminalitet, der begås af børn og unge. På baggrund af erfaringerne fra eksisterende tiltag fremhæver kommissionen generelt den tidlige, helhedsorienterede, tværsektorielle og...... sammenhængende kriminalitetsforebyggende indsats som den væsentligste, hvis man for alvor ønsker at sætte effektivt ind for at begrænse ungdomskriminaliteten. Derudover stiller kommissionen en lang række forslag om konkrete tiltag med henblik på at styrke henholdsvis den forebyggende indsats og reaktionen på...

  9. Peer review of RELAP5/MOD3 documentation

    International Nuclear Information System (INIS)

    Craddick, W.G.

    1994-01-01

    A peer review was performed on a portion of the documentation of the RELAP5/MOD3 computer code. The review was performed in two phases. The first phase was a review of Vol. III, Developmental Assessment Problems, and Vol. IV, Models and Correlations. The reviewers for this phase were Dr. Peter Griffith, Dr. Yassin Hassan, Dr. Gerald S. Lellouche, Dr. Marino di Marzo and Mr. Mark Wendel. The reviewers recommended a number of improvements, including using a frozen version of the code for assessment guided by a validation plan, better discussion of discrepancies between the code and experimental data, and better justification for flow regime maps and extension of models beyond their data base. The second phase was a review of Vol. VI, Quality Assurance of Numerical Techniques in RELAP5/MOD3. The reviewers for the second phase were Mr. Mark Wendel and Dr. Paul T. Williams. Recommendations included correction of numerous grammatical and typographical errors and better justification for the use of Lax's Equivalence Theorem

  10. Progress on MOD/RABiTSTM 2G HTS wire

    International Nuclear Information System (INIS)

    Rupich, M.W.; Zhang, W.; Li, X.; Kodenkandath, T.; Verebelyi, D.T.; Schoop, U.; Thieme, C.; Teplitsky, M.; Lynch, J.; Nguyen, N.; Siegal, E.; Scudiere, J.; Maroni, V.; Venkataraman, K.; Miller, D.; Holesinger, T.G.

    2004-01-01

    The development of the second generation (2G) high temperature superconducting wire has advanced beyond initial laboratory demonstrations and is now focused on developing and testing high critical current conductor designs required for commercial applications. The approach pursued at American Superconductor for 2G wire manufacturing is based on the combination of the RABiTS TM substrate-buffer technology with metal organic deposition (MOD) of the YBCO layer. This MOD/RABiTS TM approach has been demonstrated in 10 m lengths with critical currents of up to 184 A/cm-width (∼2.3 MA/cm 2 ) and in short length with critical currents of up to 270 A/cm-width (∼3.4 MA/cm 2 ). In addition to a high critical current, the superconducting wire must also meet stringent mechanical and electrical stability requirements that vary by application. Commercially viable architectures designed to meet these specifications have been fabricated and tested. Wires manufactured by this process have been successfully tested in prototype cable and coil applications

  11. Correlation ECE diagnostic in Alcator C-Mod

    International Nuclear Information System (INIS)

    Sung, C.; Irby, J.; Leccacorvi, R.; Vieira, R.; Oi, C.; Rice, J.; Reinke, M.; Gao, C.; Ennever, P.; Porkolab, M.; Churchill, R.; Theiler, C.; Walk, J.; Hughes, J.; Hubbard, A.; Greenwald, M.

    2015-01-01

    Correlation ECE (CECE) is a diagnostic technique that allows measurement of small amplitude electron temperature, Te, fluctuations through standard cross-correlation analysis methods. In Alcator C-Mod, a new CECE diagnostic has been installed[Sung RSI 2012], and interesting phenomena have been observed in various plasma conditions. We find that local Te fluctuations near the edge (ρ ~ 0:8) decrease across the linearto- saturated ohmic confinement transition, with fluctuations decreasing with increasing plasma density [Sung NF 2013], which occurs simultaneously with rotation reversals [Rice NF 2011]. Te fluctuations are also reduced across core rotation reversals with an increase of plasma density in RF heated L-mode plasmas, which implies that the same physics related to the reduction of Te fluctuations may be applied to both ohmic and RF heated L-mode plasmas. In I-mode plasmas, we observe the reduction of core Te fluctuations, which indicates changes of turbulence occur not only in the pedestal region but also in the core across the L/I transition [White NF 2014]. The present CECE diagnostic system in C-Mod and these experimental results are described in this paper

  12. Evaluation of the RELAP5/MOD3 multidimensional component model

    International Nuclear Information System (INIS)

    Tomlinson, E.T.; Rens, T.E.; Coffield, R.D.

    1994-01-01

    Accurate plenum predictions, which are directly related to the mixing models used, are an important plant modeling consideration because of the consequential impact on basic transient performance calculations for the integrated system. The effect of plenum is a time shift between inlet and outlet temperature changes to the particular volume. Perfect mixing, where the total volume interacts instantaneously with the total inlet flow, does not occur because of effects such as inlet/outlet nozzle jetting, flow stratification, nested vortices within the volume and the general three-dimensional velocity distribution of the flow field. The time lag which exists between the inlet and outlet flows impacts the predicted rate of temperature change experienced by various plant system components and this impacts local component analyses which are affected by the rate of temperature change. This study includes a comparison of two-dimensional plenum mixing predictions using CFD-FLOW3D, RELAP5/MOD3 and perfect mixing models. Three different geometries (flat, square and tall) are assessed for scalar transport times using a wide range of inlet velocity and isothermal conditions. In addition, the three geometries were evaluated for low flow conditions with the inlet flow experiencing a large step temperature decrease. A major conclusion from this study is that the RELAP5/MOD3 multidimensional component model appears to be adequately predicting plenum mixing for a wide range of thermal-hydraulic conditions representative of plant transients

  13. Testing Gyrokinetics on C-Mod and NSTX

    International Nuclear Information System (INIS)

    Redi, M.H.; Dorland, W.; Fiore, C.L.; Stutman, D.; Baumgaertel, J.A.; Davis, B.; Kaye, S.M.; McCune, D.C.; Menard, J.; Rewoldt, G.

    2005-01-01

    Quantitative benchmarks of computational physics codes against experiment are essential for the credible application of such codes. Fluctuation measurements can provide necessary critical tests of nonlinear gyrokinetic simulations, but such require extraordinary computational resources. Linear micro-stability calculations with the GS2 [1] gyrokinetic code have been carried out for tokamak and ST experiments which exhibit internal transport barriers (ITB) and good plasma confinement. Qualitative correlation is found for improved confinement before and during ITB plasmas on Alcator C-Mod [2] and NSTX [3], with weaker long wavelength micro-instabilities in the plasma core regions. Mixing length transport models are discussed. The NSTX L-mode is found to be near marginal stability for kinetic ballooning modes. Fully electromagnetic, linear, gyrokinetic calculations of the Alcator C-Mod ITB during off-axis rf heating, following four plasma species and including the complete electron response show ITG/TEM microturbulence is suppressed in the plasma core and in the barrier region before barrier formation, without recourse to the usual requirements of velocity shear or reversed magnetic shear [4-5]. No strongly growing long or short wavelength drift modes are found in the plasma core but strong ITG/TEM and ETG drift wave turbulence is found outside the barrier region. Linear microstability analysis is qualitatively consistent with the experimental transport analysis, showing low transport inside and high transport outside the ITB region before barrier formation, without consideration of ExB shear stabilization

  14. Upgrade of the RFX-mod real time control system

    Energy Technology Data Exchange (ETDEWEB)

    Manduchi, G., E-mail: gabriele.manduchi@igi.cnr.it [Consorzio RFX, Euratom-ENEA Association, Corso Stati Uniti 4, Padova 35127 (Italy); Barbalace, A.; Luchetta, A.; Soppelsa, A.; Taliercio, C.; Zampiva, E. [Consorzio RFX, Euratom-ENEA Association, Corso Stati Uniti 4, Padova 35127 (Italy)

    2012-12-15

    Highlights: Black-Right-Pointing-Pointer The paper describes the experience in running the real-time control system of RFX-mod. Black-Right-Pointing-Pointer It proposes a new architecture based multicore technology. Black-Right-Pointing-Pointer It analyzes two different solutions for data acquisition. Black-Right-Pointing-Pointer It discusses the effect of non simultaneous sampling in acquisition. Black-Right-Pointing-Pointer It provides some preliminary performance measurements. - Abstract: The real-time control system of RFX-mod, in operation since 2005, has been successful and has allowed several important achievements in the RFX physics research program. As a consequence of this fact, new control algorithms are under investigation, which are more demanding in terms of both enhanced computing power and reduced system latency, currently around 1.5 ms. For this reason, a major upgrade of the system is being considered, and a new architecture has been proposed, taking advantage of the rapid evolution of computer technology in the last years. The central component of the new architecture is a Linux-based multicore server, where individual cores replace the VME computers. The server is connected to the I/O via PCI-e based bus extenders, and every PCI-e connection is managed by a separate core. The system is supervised by MARTe, a software framework for real-time applications written in C++ and developed at JET and currently used for the JET vertical stabilization and in other fusion devices.

  15. Internal transport barriers on Alcator C-Mod

    International Nuclear Information System (INIS)

    Fiore, C.L.; Rice, J.E.; Bonoli, P.T.; Boivin, R.L.; Goetz, J.A.; Hubbard, A.E.; Hutchinson, I.H.; Granetz, R.S.; Greenwald, M.J.; Marmar, E.S.; Mossessian, D.; Porkolab, M.; Taylor, G.; Snipes, J.; Wolfe, S.M.; Wukitch, S.J.

    2001-01-01

    The formation of internal transport barriers (ITBs) has been observed in the core region of Alcator C-Mod [I. H. Hutchinson et al., Phys. Plasmas 1, 1511 (1994)] under a variety of conditions. The improvement in core confinement following pellet injection (pellet enhanced performance or PEP mode) has been well documented on Alcator C-Mod in the past. Recently three new ITB phenomena have been observed which require no externally applied particle or momentum input. Short lived ITBs form spontaneously following the high confinement to low confinement mode transition and are characterized by a large increase in the global neutron production (enhanced neutron or EN modes). Experiments with ion cyclotron range of frequencies power injection to the plasma off-axis on the high field side results in the central density rising abruptly and becoming peaked. The ITB formed at this time lasts for ten energy confinement times. The central toroidal rotation velocity decreases and changes sign as the density rises. Similar spontaneous ITBs have been observed in ohmically heated H-mode plasmas. All of these ITB events have strongly peaked density profiles with a minimum in the density scale length occurring near r/a=0.5 and have improved confinement parameters in the core region of the plasma

  16. Transport Studies in Alcator C-Mod ITB Plasmas

    Science.gov (United States)

    Fiore, C. L.; Bonoli, P. T.; Ernst, D.; Greenwald, M. J.; Ince-Cushman, A.; Lin, L.; Marmar, E. S.; Porkolab, M.; Rice, J. E.; Wukitch, S.; Rowan, W.; Bespamyatnov, I.; Phillips, P.

    2008-11-01

    Internal transport barriers occur in C-Mod plasmas that have off-axis ICRF heating and also in Ohmic H-mode plasmas. These ITBs are marked by highly peaked density and pressure profiles, as they rely on a reduction of particle and thermal flux in the barrier region which allows the neoclassical pinch to peak the central density without reducing the central temperature. Enhancement of several core diagnostics has resulted in increased understanding of C-Mod ITBs. Ion temperature profile measurements have been obtained using an innovative design for x-ray crystal spectrometry and clearly show a barrier forming in the ion temperature profile. The phase contrast imaging (PCI) provides limited localization of the ITB related fluctuations that increase in strength as the central density increases. Simulation of triggering conditions, integrated simulations with fluctuation measurements, parametric studies, and transport implications of fully ionized boron impurity profiles in the plasma are under study. A summary of these results will be presented.

  17. Pulsed klystrons with feedback controlled mod-anode modulators

    Energy Technology Data Exchange (ETDEWEB)

    Reass, William A [Los Alamos National Laboratory; Baca, David M [Los Alamos National Laboratory; Jerry, Davis L [Los Alamos National Laboratory; Rees, Daniel E [Los Alamos National Laboratory

    2009-01-01

    This paper describes a fast rise and fall, totem-pole mod-anode modulators for klystron application. Details of these systems as recently installed utilizing a beam switch tube ''on-deck'' and a planar triode ''off-deck'' in a grid-catch feedback regulated configuration will be provided. The grid-catch configuration regulates the klystron mod-anode voltage at a specified set-point during switching as well as providing a control mechanism that flat-top regulates the klystron beam current during the pulse. This flat-topped klystron beam current is maintained while the capacitor bank droops. In addition, we will review more modern on-deck designs using a high gain, high voltage planar triode as a regulating and switching element. These designs are being developed, tested, and implemented for the Los Alamos Neutron Science Center (LANSCE) accelerator refurbishment project, ''LANSCE-R''. An advantage of the planar triode is that the tube can be directly operated with solid state linear components and provides for a very compact design. The tubes are inexpensive compared to stacked semiconductor switching assemblies and also provide a linear control capability. Details of these designs are provided as well as operational and developmental results.

  18. Disruption Neutral Point Experiment on Alcator C-Mod

    Science.gov (United States)

    Granetz, R. S.; Nakamura, Y.

    2000-10-01

    Disruptions of single-null elongated plasmas generally result in loss of vertical position control, leading to a current quench occurring at the top or bottom of the machine, with all the attendant problems of halo and eddy currents flowing in divertor structures. On JT-60U, it has been found that if the plasma is operated with its magnetic axis at a particular height, called the neutral point, the initial vertical drift after a thermal quench is significantly slower than usual, and sometimes can even be arrested, thereby avoiding a current quench in the divertor region entirely. In an ongoing collaboration between MIT and JAERI, the neutral point concept is being tested in Alcator C-Mod, which has a significantly higher plasma elongation than JT-60U (1.65 vs 1.3). Calculations using TSC predict a neutral point at z~=+1 cm above the midplane (a=22 cm). The existence of a neutral point has now been experimentally confirmed, albeit at a height of z=+2.7 cm. The plasma has remained vertically stable for up to 9 ms after the disruption thermal quench, which in principle, is long enough for the PF control system to respond, if programmed appropriately. In addition, the physics of the neutral point stability on C-Mod appears to be somewhat different than that on JT-60U.

  19. 3D effects on RWM physics in RFX-mod

    International Nuclear Information System (INIS)

    Baruzzo, M.; Bolzonella, T.; Guo, S.C.; Marchiori, G.; Paccagnella, R.; Soppelsa, A.; Wang, Z.R.; Liu, Y.Q.; Villone, F.

    2011-01-01

    In this paper insights into the behaviour of resistive wall modes (RWMs) in the RFX-mod reversed field pinch device are given, with a focus on 3D issues in the characterization of the m spectrum of the mode and on the study of multi-harmonic coupling. In the first part of the paper the interaction between multiple unstable RWMs is studied and the presence of a coupling between different poloidal components of the most unstable RWM is demonstrated, taking advantage of the flexibility of the RFX-mod control system. In the second part of the work, the dependence of the growth rates of RWMs on a complete set of plasma parameters is studied in order to create a complete and homogeneous database, which permits a careful validation of stability codes. Finally, the experimental data are compared with the code predictions which take into account the 3D structure of conductors around the plasma. The different effects that modify the simple description, where unstable modes can be identified with single Fourier harmonics, appear to be explained by a mixture of toroidicity-induced and 3D eddy current effects.

  20. idRHa+ProMod - Rail Hardening Control System

    International Nuclear Information System (INIS)

    Ferro, L

    2016-01-01

    idRHa+ProMod is the process control system developed by Primetals Technologies to foresee the thermo-mechanical evolution and micro-structural composition of rail steels subjected to slack quenching into idRHa+ Rail Hardening equipments in a simulation environment. This tool can be used both off-line or in-line, giving the user the chance to test and study the best cooling strategies or letting the automatic control system free to adjust the proper cooling recipe. Optimization criteria have been tailored in order to determine the best cooling conditions according to the metallurgical requirements imposed by the main rail standards and also taking into account the elastoplastic bending phenomena occurring during all stages of the head hardening process. The computational core of idRHa+ProMod is a thermal finite element procedure coupled with special algorithms developed to work out the main thermo-physical properties of steel, to predict the non-isothermal austenite decomposition into all the relevant phases and subsequently to evaluate the amount of latent heat of transformation released, the compound thermal expansion coefficient and the amount of plastic deformation in the material. Air mist and air blades boundary conditions have been carefully investigated by means of pilot plant tests aimed to study the jet impingement on rail surfaces and the cooling efficiency at all working conditions. Heat transfer coefficients have been further checked and adjusted directly on field during commissioning. idRHa+ is a trademark of Primetals Technologies Italy Srl (paper)

  1. Migration of alcator C-Mod computer infrastructure to Linux

    International Nuclear Information System (INIS)

    Fredian, T.W.; Greenwald, M.; Stillerman, J.A.

    2004-01-01

    The Alcator C-Mod fusion experiment at MIT in Cambridge, Massachusetts has been operating for twelve years. The data handling for the experiment during most of this period was based on MDSplus running on a cluster of VAX and Alpha computers using the OpenVMS operating system. While the OpenVMS operating system provided a stable reliable platform, the support of the operating system and the software layered on the system has deteriorated in recent years. With the advent of extremely powerful low cost personal computers and the increasing popularity and robustness of the Linux operating system a decision was made to migrate the data handling systems for C-Mod to a collection of PC's running Linux. This paper will describe the new system configuration, the effort involved in the migration from OpenVMS, the results of the first run campaign under the new configuration and the impact the switch may have on the rest of the MDSplus community

  2. Upgrade of the RFX-mod real time control system

    International Nuclear Information System (INIS)

    Manduchi, G.; Barbalace, A.; Luchetta, A.; Soppelsa, A.; Taliercio, C.; Zampiva, E.

    2012-01-01

    Highlights: ► The paper describes the experience in running the real-time control system of RFX-mod. ► It proposes a new architecture based multicore technology. ► It analyzes two different solutions for data acquisition. ► It discusses the effect of non simultaneous sampling in acquisition. ► It provides some preliminary performance measurements. - Abstract: The real-time control system of RFX-mod, in operation since 2005, has been successful and has allowed several important achievements in the RFX physics research program. As a consequence of this fact, new control algorithms are under investigation, which are more demanding in terms of both enhanced computing power and reduced system latency, currently around 1.5 ms. For this reason, a major upgrade of the system is being considered, and a new architecture has been proposed, taking advantage of the rapid evolution of computer technology in the last years. The central component of the new architecture is a Linux-based multicore server, where individual cores replace the VME computers. The server is connected to the I/O via PCI-e based bus extenders, and every PCI-e connection is managed by a separate core. The system is supervised by MARTe, a software framework for real-time applications written in C++ and developed at JET and currently used for the JET vertical stabilization and in other fusion devices.

  3. RELAP4/MOD6 reflood heat transfer and data comparison

    International Nuclear Information System (INIS)

    Nelson, R.A.; Sullivan, L.H.

    1981-01-01

    This discussion of RELAP4/MOD6 will be limited to the reflood heat transfer models and evaluation of these models by comparison of calculation with results from three reflood experiments. The discussion of the model includes the heat transfer surface concept, the heat transfer correlations, the superheat model and the entrainment model which presents both the two-phase heat transfer and hydraulic models. In the discussion of the reflood heat transfer, the mathematical concept of a multidimensional surface is used to represent the heat flux of a given heat transfer correlation or correlations dependent upon such variables as quality, wall superheat and flux. This concept has been used to investigate the characteristics of the correlations, which are discusssed in detail, and the way they are applied to the two-phase mixture. Of primary importance in the reflood core heat transfer is the consideration of thermal nonequilibrium between the phases and the liquid entrainment, and its distribution up the core. Results obtained to date show the heat transfer and hydraulics to be closely coupled. Comparison of the RELAP4/MOD6 reflood calculations with the data from the forced feed FLECHT and gravity feed FLECHT-SET and Semiscale reflood experiments indicates that the heat transfer and hydraulic models are operational and yield good results

  4. idRHa+ProMod - Rail Hardening Control System

    Science.gov (United States)

    Ferro, L.

    2016-03-01

    idRHa+ProMod is the process control system developed by Primetals Technologies to foresee the thermo-mechanical evolution and micro-structural composition of rail steels subjected to slack quenching into idRHa+ Rail Hardening equipments in a simulation environment. This tool can be used both off-line or in-line, giving the user the chance to test and study the best cooling strategies or letting the automatic control system free to adjust the proper cooling recipe. Optimization criteria have been tailored in order to determine the best cooling conditions according to the metallurgical requirements imposed by the main rail standards and also taking into account the elastoplastic bending phenomena occurring during all stages of the head hardening process. The computational core of idRHa+ProMod is a thermal finite element procedure coupled with special algorithms developed to work out the main thermo-physical properties of steel, to predict the non-isothermal austenite decomposition into all the relevant phases and subsequently to evaluate the amount of latent heat of transformation released, the compound thermal expansion coefficient and the amount of plastic deformation in the material. Air mist and air blades boundary conditions have been carefully investigated by means of pilot plant tests aimed to study the jet impingement on rail surfaces and the cooling efficiency at all working conditions. Heat transfer coefficients have been further checked and adjusted directly on field during commissioning. idRHa+ is a trademark of Primetals Technologies Italy Srl

  5. Comparision of calculations for the ROSA-IV LSTF with RELAP5/MOD0 and RELAP5/MOD1 (cycle 1)

    International Nuclear Information System (INIS)

    Fineman, C.P.; Tanaka, Mitsugu; Tasaka, Kanji

    1982-03-01

    10% and 2.5% cold leg break analyses have been completed for the ROSA-IV Large Scale Test Facility (LSTF) with the RELAP5/MOD0 and RELAP5/MOD1, cycle 1, computer codes. Comparisons between the calculations were made to determine any differences in the results obtained from the two versions of RELAP5. Differences in the two calculations were found which can be attributed to changes in the flow regime maps and critical flow model. (author)

  6. Modèle exploitable pour la définition de la commande du robot

    OpenAIRE

    ZIMMER-CHEVRET, Sandra; LANGLOIS, Laurent; BEN ATTAR, Amarilys

    2014-01-01

    Ce document traite de la modélisation des actions mécaniques entre l’outil et la matière. L’objectif est de définir un modèle exploitable pour la définition de la commande du robot. Dans un premier temps, le rapport présente une synthèse bibliographique des modèles des interactions mécaniques développés à ce jour. Pour un modèle choisi, les paramètres constituant ce dernier ont été calculés à partir de données expérimentales. Puis, la validité du modèle a été étudiée. Pour une même configurat...

  7. Cloud-based uniform ChIP-Seq processing tools for modENCODE and ENCODE.

    Science.gov (United States)

    Trinh, Quang M; Jen, Fei-Yang Arthur; Zhou, Ziru; Chu, Kar Ming; Perry, Marc D; Kephart, Ellen T; Contrino, Sergio; Ruzanov, Peter; Stein, Lincoln D

    2013-07-22

    Funded by the National Institutes of Health (NIH), the aim of the Model Organism ENCyclopedia of DNA Elements (modENCODE) project is to provide the biological research community with a comprehensive encyclopedia of functional genomic elements for both model organisms C. elegans (worm) and D. melanogaster (fly). With a total size of just under 10 terabytes of data collected and released to the public, one of the challenges faced by researchers is to extract biologically meaningful knowledge from this large data set. While the basic quality control, pre-processing, and analysis of the data has already been performed by members of the modENCODE consortium, many researchers will wish to reinterpret the data set using modifications and enhancements of the original protocols, or combine modENCODE data with other data sets. Unfortunately this can be a time consuming and logistically challenging proposition. In recognition of this challenge, the modENCODE DCC has released uniform computing resources for analyzing modENCODE data on Galaxy (https://github.com/modENCODE-DCC/Galaxy), on the public Amazon Cloud (http://aws.amazon.com), and on the private Bionimbus Cloud for genomic research (http://www.bionimbus.org). In particular, we have released Galaxy workflows for interpreting ChIP-seq data which use the same quality control (QC) and peak calling standards adopted by the modENCODE and ENCODE communities. For convenience of use, we have created Amazon and Bionimbus Cloud machine images containing Galaxy along with all the modENCODE data, software and other dependencies. Using these resources provides a framework for running consistent and reproducible analyses on modENCODE data, ultimately allowing researchers to use more of their time using modENCODE data, and less time moving it around.

  8. TRAC-PF1/MOD1 independent assessment: Semiscale Mod-2A intermediate break test S-IB-3

    International Nuclear Information System (INIS)

    Kmetyk, L.N.

    1986-02-01

    The TRAC-PF1/MOD1 independent assessment project at Sandia National Laboratories is part of an overall effort funded by the NRC to determine the ability of various system codes to predict the detailed thermal/hydraulic response of light water reactors during accident and off-normal conditions. The TRAC code is being assessed at SNLA against test data from various integral and separate effects test facilities. As part of this assessment matrix, an intermediate break test (S-IB-3), performed at the Semiscale Mod-2A facility, has been analyzed. Using an input model with a 3-D VESSEL component, the vessel and downcomer inventories during 3-IB-3 were generally well predicted, but the core heatup was underpredicted compared to data. An equivalent calculation with an all 1-D input model ran about twice as fast as our basecase analysis using a 3-D VESSEL in the input model, but the results of the two calculations diverged significantly for many parameters of interest, with the 3-D VESSEL model results in better agreement with data. 22 refs., 100 figs

  9. Identification of functional elements and regulatory circuits by Drosophila modENCODE

    Energy Technology Data Exchange (ETDEWEB)

    Roy, Sushmita; Ernst, Jason; Kharchenko, Peter V.; Kheradpour, Pouya; Negre, Nicolas; Eaton, Matthew L.; Landolin, Jane M.; Bristow, Christopher A.; Ma, Lijia; Lin, Michael F.; Washietl, Stefan; Arshinoff, Bradley I.; Ay, Ferhat; Meyer, Patrick E.; Robine, Nicolas; Washington, Nicole L.; Stefano, Luisa Di; Berezikov, Eugene; Brown, Christopher D.; Candeias, Rogerio; Carlson, Joseph W.; Carr, Adrian; Jungreis, Irwin; Marbach, Daniel; Sealfon, Rachel; Tolstorukov, Michael Y.; Will, Sebastian; Alekseyenko, Artyom A.; Artieri, Carlo; Booth, Benjamin W.; Brooks, Angela N.; Dai, Qi; Davis, Carrie A.; Duff, Michael O.; Feng, Xin; Gorchakov, Andrey A.; Gu, Tingting; Henikoff, Jorja G.; Kapranov, Philipp; Li, Renhua; MacAlpine, Heather K.; Malone, John; Minoda, Aki; Nordman, Jared; Okamura, Katsutomo; Perry, Marc; Powell, Sara K.; Riddle, Nicole C.; Sakai, Akiko; Samsonova, Anastasia; Sandler, Jeremy E.; Schwartz, Yuri B.; Sher, Noa; Spokony, Rebecca; Sturgill, David; van Baren, Marijke; Wan, Kenneth H.; Yang, Li; Yu, Charles; Feingold, Elise; Good, Peter; Guyer, Mark; Lowdon, Rebecca; Ahmad, Kami; Andrews, Justen; Berger, Bonnie; Brenner, Steven E.; Brent, Michael R.; Cherbas, Lucy; Elgin, Sarah C. R.; Gingeras, Thomas R.; Grossman, Robert; Hoskins, Roger A.; Kaufman, Thomas C.; Kent, William; Kuroda, Mitzi I.; Orr-Weaver, Terry; Perrimon, Norbert; Pirrotta, Vincenzo; Posakony, James W.; Ren, Bing; Russell, Steven; Cherbas, Peter; Graveley, Brenton R.; Lewis, Suzanna; Micklem, Gos; Oliver, Brian; Park, Peter J.; Celniker, Susan E.; Henikoff, Steven; Karpen, Gary H.; Lai, Eric C.; MacAlpine, David M.; Stein, Lincoln D.; White, Kevin P.; Kellis, Manolis

    2010-12-22

    To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. We have generated more than 700 data sets and discovered protein-coding, noncoding, RNA regulatory, replication, and chromatin elements, more than tripling the annotated portion of the Drosophila genome. Correlated activity patterns of these elements reveal a functional regulatory network, which predicts putative new functions for genes, reveals stage- and tissue-specific regulators, and enables gene-expression prediction. Our results provide a foundation for directed experimental and computational studies in Drosophila and related species and also a model for systematic data integration toward comprehensive genomic and functional annotation. Several years after the complete genetic sequencing of many species, it is still unclear how to translate genomic information into a functional map of cellular and developmental programs. The Encyclopedia of DNA Elements (ENCODE) (1) and model organism ENCODE (modENCODE) (2) projects use diverse genomic assays to comprehensively annotate the Homo sapiens (human), Drosophila melanogaster (fruit fly), and Caenorhabditis elegans (worm) genomes, through systematic generation and computational integration of functional genomic data sets. Previous genomic studies in flies have made seminal contributions to our understanding of basic biological mechanisms and genome functions, facilitated by genetic, experimental, computational, and manual annotation of the euchromatic and heterochromatic genome (3), small genome size, short life cycle, and a deep knowledge of development, gene function, and chromosome biology. The functions

  10. Edge Minority Heating Experiment in Alcator C-Mod

    International Nuclear Information System (INIS)

    Zweben, S.J.; Terry, J.L.; Bonoli, P.; Budny, R.; Chang, C.S.; Fiore, C.; Schilling, G.; Wukitch, S.; Hughes, J.; Lin, Y.; Perkins, R.; Porkolab, M.; Alcator C-Mod Team

    2005-01-01

    An attempt was made to control global plasma confinement in the Alcator C-Mod tokamak by applying ion cyclotron resonance heating (ICRH) power to the plasma edge in order to deliberately create a minority ion tail loss. In theory, an edge fast ion loss could modify the edge electric field and so stabilize the edge turbulence, which might then reduce the H-mode power threshold or improve the H-mode barrier. However, the experimental result was that edge minority heating resulted in no improvement in the edge plasma parameters or global stored energy, at least at power levels of P RF (le) 5.5 MW. A preliminary analysis of these results is presented and some ideas for improvement are discussed

  11. Two dimensional radiated power diagnostics on Alcator C-Mod

    International Nuclear Information System (INIS)

    Reinke, M. L.; Hutchinson, I. H.

    2008-01-01

    The radiated power diagnostics for the Alcator C-Mod tokamak have been upgraded to measure two dimensional structure of the photon emissivity profile in order to investigate poloidal asymmetries in the core radiation. Commonly utilized unbiased absolute extreme ultraviolet (AXUV) diode arrays view the plasma along five different horizontal planes. The layout of the diagnostic set is shown and the results from calibrations and recent experiments are discussed. Data showing a significant, 30%-40%, inboard/outboard emissivity asymmetry during ELM-free H-mode are presented. The ability to use AXUV diode arrays to measure absolute radiated power is explored by comparing diode and resistive bolometer-based emissivity profiles for highly radiative L-mode plasmas seeded with argon. Emissivity profiles match in the core but disagree radially outward resulting in an underprediction of P rad of nearly 50% by the diodes compared to P rad determined using resistive bolometers.

  12. Fooling the user? Modding in the video game industry

    Directory of Open Access Journals (Sweden)

    Merlin Münch

    2013-06-01

    Full Text Available Over the years, the video game industry has grown into one of the largest, most profitable entertainment industries in the world. In a highly competitive industry, legal difficulties to safeguard successful game concepts from copycats contribute to a trend of risk aversion and reliance on established game franchises. It does not come as a surprise then, that user-driven innovation, or 'modding', has come to play a considerably important role for the industry in recent years. While modders are becoming increasingly aware of the financial weight of their activities, game companies seek to secure the legal ownership of the content they create. By means of a literature review this article seeks to investigate the ongoing juridification of the relationship between modders and the industry, in order to provide a brief insight into the complex issue of intellectual property in relation to user generated content and the tensions that arise due to a mesh of messy legal and social arrangements.

  13. Self-similar current decay experiment in RFX-mod

    International Nuclear Information System (INIS)

    Zanca, Paolo

    2007-01-01

    The self-similar current decay (SSCD) has been suggested as a promising operation for reversed field pinch devices by numerical simulations, which show a decrease in modes amplitude and stochasticity when the magnetic field is forced to decay at a suitable rate at a fixed radial profile (Nebel et al 2002 Phys. Plasmas 9 4968). The first experimental test of SSCD has recently been performed in RFX-mod. An initial fast decrease in the mode amplitudes (about 40% of the initial value) is observed. After that, a regime characterized by transient states close to the single-helicity condition (Cappello and Paccagnella 1992 Phys. Fluids B 4 611, Finn et al 1992 Phys. Fluids B 4 1262) is established. This brings about a 50% increase in the global confinement parameters

  14. Molybdenum erosion measurements in Alcator C-Mod

    Energy Technology Data Exchange (ETDEWEB)

    Wampler, W.R. [Sandia National Labs., Albuquerque, NM (United States); LaBombard, B.; Lipshultz, B.; Pappas, D.; Pitcher, C.S. [Massachusetts Inst. of Tech., Cambridge, MA (United States); McCracken, G.M. [JET Joint Undertaking, Abingdon (United Kingdom)

    1998-05-01

    Erosion of molybdenum was measured on a set of 21 tiles after a run campaign of 1,090 shots in the Alcator C-Mod tokamak. The net erosion of molybdenum, was determined from changes in the depth of a thin chromium marker layer measured by Rutherford backscattering. Net Mo erosion was found to be approximately 150 nm near the outer divertor strike point, and much less everywhere else. Gross erosion rates by sputtering were estimated using ion energies and fluxes obtained from Langmuir probe measurements of edge-plasma conditions. Predicted net erosion using calculated gross erosion with prompt redeposition and measured net erosion agree within a factor of 3. Sputtering by boron and molybdenum impurities dominates erosion.

  15. Nonequilibrium constitutive models for RELAP5/MOD2

    International Nuclear Information System (INIS)

    Lin, J.C.; Trapp, J.A.; Riemke, R.A.; Ransom, V.H.

    1983-01-01

    RELAP5/MOD2 is a new version of RELAP5 containing improved modeling features that provide a generic pressurized-water transient simulation capability. In particular, the nonequilibrium modeling capability has been generalized to include conditions that occur in operational transients including repressurization and emergency-feed-water injection with loss-of-coolant accidents. The improvements include addition of a second energy equation to the hydrodynamic model, addition of nonequilibrium heat-transfer models, and the associated nonequilibrium vapor-generation models. The objective of this paper is to describe these models and to report the developmental assessment results obtained from similar of several separate effects experiments. The assessment shows that RELAP5 calculated results are in good agreement with data and the nonequilibrium phenomena are properly modeled

  16. Fast Wave Transmission Measurements on Alcator C-Mod

    Science.gov (United States)

    Reardon, J.; Bonoli, P. T.; Porkolab, M.; Takase, Y.; Wukitch, S. J.

    1997-11-01

    Data are presented from an array of single-turn loop probes newly installed on the inner wall of C-Mod, directly opposite one of the two fast-wave antennas. The 8-loop array extends 32^circ in the toroidal direction at the midplane and can distinguish electromagnetic from electrostatic modes. Data are acquired by 1GHz digitizer, spectrum analyzer, and RF detector circuit. Phase measurements during different heating scenarios show evidence of both standing and travelling waves. The measurement of toroidal mode number N_tor (conserved under the assumption of axisymmetry) is used to guide the toroidal full-wave code TORIC(Brambilla, M., IPP Report 5/66, February 1996). Amplitude measurements show modulation both by Type III ELMs and sawteeth; the observed sawtooth modulation may be interpreted as due to changes in central absorption. The amplitude of tildeB_tor measured at the inner wall is compared to the prediction of TORIC.

  17. PREFACE: Modern Technologies in Industrial Engineering (ModTech2015)

    Science.gov (United States)

    Oanta, E.; Comaneci, R.; Carausu, C.; Placzek, M.; Cohal, V.; Topala, P.; Nedelcu, D.

    2015-11-01

    The dominant feature of the current stage of society development is the update, refinement and innovation of the technological processes and products whose ultimate goal is to satisfy the market requirements. New and modern technologies should be considered in terms of their applicability in industry while the materials can lead to an increase in the quality of the end products. Replacing the existing technologies with innovative and eco-efficient technologies can contribute to an added value increase in the production of new materials. Materials are one of the most dynamic and prospective fields, with applications in all other fields. The development of new advanced materials and technologies shall contribute to the procurement of a wide range of reliable products, with competitive prices and worldwide performance, high sensitivity and functionality, user-friendly and reduced energy consumption, for different industrial applications. Research in the field of advanced/intelligent materials supposes a fundamental, experimental, laboratory and technological research and its approach has to be linked to the application. This involves, even for the niche fields, complex projects which result in scientific issues in top journals, patents and functional models. The third edition of ModTech International Conference was held in Mamaia, Romania, between June 17-20, with the Professional Association in Modern Manufacturing Technologies, ModTech, as main organizer, and the Constanta Maritime University, Constanta, Romania, Silesian University of Technology, Gliwice, Poland, the Technical University of Chisinau, Republic of Moldova and the Donetsk National Technical University, Donetsk, Ukraine as co-organizers. The ModTech2015 International Conference brought together representatives of technology and materials manufacturers, various universities, professional associations and research institutes that exchanged the latest knowledge on the conference topics. This edition was

  18. High speed movies of turbulence in Alcator C-Mod

    International Nuclear Information System (INIS)

    Terry, J.L.; Zweben, S.J.; Bose, B.; Grulke, O.; Marmar, E.S.; Lowrance, J.; Mastrocola, V.; Renda, G.

    2004-01-01

    A high speed (250 kHz), 300 frame charge coupled device camera has been used to image turbulence in the Alcator C-Mod Tokamak. The camera system is described and some of its important characteristics are measured, including time response and uniformity over the field-of-view. The diagnostic has been used in two applications. One uses gas-puff imaging to illuminate the turbulence in the edge/scrape-off-layer region, where D 2 gas puffs localize the emission in a plane perpendicular to the magnetic field when viewed by the camera system. The dynamics of the underlying turbulence around and outside the separatrix are detected in this manner. In a second diagnostic application, the light from an injected, ablating, high speed Li pellet is observed radially from the outer midplane, and fast poloidal motion of toroidal striations are seen in the Li + light well inside the separatrix

  19. Mod-ϕ convergence normality zones and precise deviations

    CERN Document Server

    Féray, Valentin; Nikeghbali, Ashkan

    2016-01-01

    The canonical way to establish the central limit theorem for i.i.d. random variables is to use characteristic functions and Lévy’s continuity theorem. This monograph focuses on this characteristic function approach and presents a renormalization theory called mod-ϕ convergence. This type of convergence is a relatively new concept with many deep ramifications, and has not previously been published in a single accessible volume. The authors construct an extremely flexible framework using this concept in order to study limit theorems and large deviations for a number of probabilistic models related to classical probability, combinatorics, non-commutative random variables, as well as geometric and number-theoretical objects. Intended for researchers in probability theory, the text is carefully well-written and well-structured, containing a great amount of detail and interesting examples. .

  20. Stationary density profiles in the Alcator C-mod tokamak

    International Nuclear Information System (INIS)

    Kesner, J.; Ernst, D.; Hughes, J.; Mumgaard, R.; Shiraiwa, S.; Whyte, D.; Scott, S.

    2012-01-01

    In the absence of an internal particle source, plasma turbulence will impose an intrinsic relationship between an inwards pinch and an outwards diffusion resulting in a stationary density profile. The Alcator C-mod tokamak utilizes RF heating and current drive so that fueling only occurs in the vicinity of the separatrix. Discharges that transition from L-mode to I-mode are seen to maintain a self-similar stationary density profile as measured by Thomson scattering. For discharges with negative magnetic shear, an observed rise of the safety factor in the vicinity of the magnetic axis appears to be accompanied by a decrease of electron density, qualitatively consistent with the theoretical expectations.

  1. Hot particle dose calculations using the computer code VARSKIN Mod 2

    International Nuclear Information System (INIS)

    Durham, J.S.

    1991-01-01

    The only calculational model recognised by the Nuclear Regulatory Commission (NRC) for hot particle dosimetry is VARSKIN Mod 1. Because the code was designed to calculate skin dose from distributed skin contamination and not hot particles, it is assumed that the particle has no thickness and, therefore, that no self-absorption occurs within the source material. For low energy beta particles such as those emitted from 60 Co, a significant amount of self-shielding occurs in hot particles and VARSKIN Mod 1 overestimates the skin dose. In addition, the presence of protective clothing, which will reduce the calculated skin dose for both high and low energy beta emitters, is not modelled in VARSKIN Mod 1. Finally, there is no provision in VARSKIN Mod 1 to calculate the gamma contribution to skin dose from radionuclides that emit both beta and gamma radiation. The computer code VARSKIN Mod 1 has been modified to model three-dimensional sources, insertion of layers of protective clothing between the source and skin, and gamma dose from appropriate radionuclides. The new code, VARSKIN Mod 2, is described and the sensitivity of the calculated dose to source geometry, diameter, thickness, density, and protective clothing thickness are discussed. Finally, doses calculated using VARSKIN Mod 2 are compared to doses measured from hot particles found in nuclear power plants. (author)

  2. CONTEMPT4/MOD6: a multicompartment containment system analysis program

    International Nuclear Information System (INIS)

    Lin, C.C.; Economos, C.; Lehner, J.R.; Maise, G.

    1986-03-01

    CONTEMPT4/MOD6 is a digital computer program that describes the response of multicompartment containment system subjected to postulated loss-of-coolant accident (LOCA) conditions. The program is written in FORTRAN IV and can accomodate both pressurized water reactor (PWR) and boiling water reactor (BWR) containment systems. Also, both design basis accident (DBA) and degraded core type LOCA conditions can be analyzed. The program calculates the time variation of compartment pressures, temperatures and mass and energy inventories due to intercompartment mass and energy exchange taking into account user supplied descriptions of compartments, intercompartment junction flow areas, LOCA source terms and user selected problem features. Analytical models available to describe containment systems include models for containment fans and pumps, cooling sprays, heat conducting structures, sump drains, PWR ice condensers and BWR pressure suppression systems. To accommodate degraded core type accidents, analytical models for hydrogen and carbon monoxide combustion within compartments and energy transfer due to gas radiation are also provided. Dynamic storage allocation (DSA) is used to limit the amount of computer core used for each problem. The flexibility needed to more realistically model the complexity of prototypical containments is provided by the multicompartment capability (up to 999 individual compartments) and generalized user oriented input data descriptions. The program employs an implicit algorithm to compute junction flow when numerically induced flow oscillations are encountered. This capability provides significant reduction of computer run time relative to previous codes in the CONTEMPT series. Descriptions of these analytical models are presented, together with input instructions for the CONTEMPT4/MOD6 program and sample problem results. 23 refs., 62 figs

  3. Neutral particle dynamics in the Alcator C-Mod tokamak

    International Nuclear Information System (INIS)

    Niemczewski, A.P.

    1995-08-01

    This thesis presents an experimental study of neutral particle dynamics in the Alcator C-Mod tokamak. The primary diagnostic used is a set of six neutral pressure gauges, including special-purpose gauges built for in situ tokamak operation. While a low main chamber neutral pressure coincides with high plasma confinement regimes, high divertor pressure is required for heat and particle flux dispersion in future devices such as ITER. Thus we examine conditions that optimize divertor compression, defined here as a divertor-to-midplane pressure ratio. We find both pressures depend primarily on the edge plasma regimes defined by the scrape-off-layer heat transport. While the maximum divertor pressure is achieved at high core plasma densities corresponding to the detached divertor state, the maximum compression is achieved in the high-recycling regime. Variations in the divertor geometry have a weaker effect on the neutral pressures. For otherwise similar plasmas the divertor pressure and compression are maximum when the strike point is at the bottom of the vertical target plate. We introduce a simple flux balance model, which allows us to explain the divertor neutral pressure across a wide range of plasma densities. In particular, high pressure sustained in the detached divertor (despite a considerable drop in the recycling source) can be explained by scattering of neutrals off the cold plasma plugging the divertor throat. Because neutrals are confined in the divertor through scattering and ionization processes (provided the mean-free-paths are much shorter than a typical escape distance) tight mechanical baffling is unnecessary. The analysis suggests that two simple structural modifications may increase the divertor compression in Alcator C-Mod by a factor of about 5. Widening the divertor throat would increase the divertor recycling source, while closing leaks in the divertor structure would eliminate a significant neutral loss mechanism. 146 refs., 82 figs., 14 tabs

  4. Neutral particle dynamics in the Alcator C-Mod tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Niemczewski, Artur P. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    1995-08-01

    This thesis presents an experimental study of neutral particle dynamics in the Alcator C-Mod tokamak. The primary diagnostic used is a set of six neutral pressure gauges, including special-purpose gauges built for in situ tokamak operation. While a low main chamber neutral pressure coincides with high plasma confinement regimes, high divertor pressure is required for heat and particle flux dispersion in future devices such as ITER. Thus we examine conditions that optimize divertor compression, defined here as a divertor-to-midplane pressure ratio. We find both pressures depend primarily on the edge plasma regimes defined by the scrape-off-layer heat transport. While the maximum divertor pressure is achieved at high core plasma densities corresponding to the detached divertor state, the maximum compression is achieved in the high-recycling regime. Variations in the divertor geometry have a weaker effect on the neutral pressures. For otherwise similar plasmas the divertor pressure and compression are maximum when the strike point is at the bottom of the vertical target plate. We introduce a simple flux balance model, which allows us to explain the divertor neutral pressure across a wide range of plasma densities. In particular, high pressure sustained in the detached divertor (despite a considerable drop in the recycling source) can be explained by scattering of neutrals off the cold plasma plugging the divertor throat. Because neutrals are confined in the divertor through scattering and ionization processes (provided the mean-free-paths are much shorter than a typical escape distance) tight mechanical baffling is unnecessary. The analysis suggests that two simple structural modifications may increase the divertor compression in Alcator C-Mod by a factor of about 5. Widening the divertor throat would increase the divertor recycling source, while closing leaks in the divertor structure would eliminate a significant neutral loss mechanism.

  5. High performance discharges and capabilities in Alcator C-Mod

    International Nuclear Information System (INIS)

    Porkolab, M.

    1996-01-01

    Alcator C-Mod is a compact, diverted, shaped, high magnetic field (B = 9 T) tokamak operating at the Massachusetts Institute of Technology Plasma Fusion Center. The machine interior is all metallic, and the walls and divertor region are covered with molybdenum tiles. The vacuum vessel is a continuous, thick wall stainless steel construction, prototypical of future fusion devices (e.g., ITER). Typical discharge cleaning utilizes ECDC, or electron-cyclotron discharge cleaning, in the steady state at low magnetic field (0.0875 T). While its dimensions are compact (R = 0.67 m, a = 0.22 m, K = 1.8), C-Mod is designed to operate up to 2.5 MA at 9.0 T magnetic field. To present date the machine has operated at currents up to 1.5 MA at B = 5.3 T, and magnetic fields up to 8.0 T at I p = 1.2 MA. Due to the high current density, line average densities of 4.0 x 10 20 m -3 are obtained with gas fueling, and peak densities in excess of 1.0 x 10 21 m -3 have been obtained with pellet fueling. Typical pulse lengths are up to 2.0 seconds, with a flat-top of typically 1.0 sec. Presently the device is equipped with 4.0 MW of ICRF heating power operating at 80 MHz, but this capability is being upgraded to 8.0 MW with the addition of 4.0 MW of tunable ICRF power operating at 40.80 MHz. A 20 pellet/pulse deuterium injector is operational, and a 4 pellet Li injector is also operational. To reduce the influx of metallic impurities during high power operation, recently boronization of the machine interior was begun prior to plasma discharges, this allowed plasma operation with full auxiliary power capability without excessive radiative power losses from the plasma core. 7 refs

  6. A fast, simple method for screening radiation susceptibility genes by RNA interference

    International Nuclear Information System (INIS)

    Tsuji, Atsushi B.; Sudo, Hitomi; Sugyo, Aya; Otsuki, Marika; Miyagishi, Makoto; Taira, Kazunari; Imai, Takashi; Harada, Yoshi-nobu

    2005-01-01

    Radiotherapy can cause unacceptable levels of damage to normal tissues in some cancer patients. To understand the molecular mechanisms underlying radiation-induced physiological responses, and to be able to predict the radiation susceptibility of normal tissues in individual patients, it is important to identify a comprehensive set of genes responsible for radiation susceptibility. We have developed a simple and rapid 96-well screening protocol using cell proliferation assays and RNA interference to identify genes associated with radiation susceptibility. We evaluated the performance of alamarBlue-, BrdU-, and sulforhodamine B-based cell proliferation assays using the 96-well format. Each proliferation assay detected the known radiation susceptibility gene, PRKDC. In a trial screen using 28 shRNA vectors, another known gene, CDKN1A, and one new radiation susceptibility gene, ATP5G3, were identified. Our results indicate that this method may be useful for large-scale screens designed to identify novel radiation susceptibility genes

  7. Assessment of RELAP5/MOD3 with condensation experiment for pure steam condensation in a vercal tube

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sang Jae; No, Hee Cheon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1999-12-31

    The film condensation models in RELAP5/MOD3.1 and RELAP5/MOD3.2 are assessed with the data of experiment performed in the scaled down condensation experimental facility with a single vertical tube of inner diameter of 46 mm in the range of pressure 0.1 {approx} 7.5 MPa for the PSCS(Passive Secondary Condenser System). Both MOD3.1 and MOD3.2 don`t shows any reliable predictions of the experimental data. The RELAP5/MOD3.1 overpredicts the heat transfer coefficients of experiment, whereas the RELAP5/MOD3.2 underpredicts those data. It is recommended that the film condensation model in RELAP5/MOD3.2 should be modified to have a larger heat transfer coefficient than those of the present model to give the reliable predictions. 7 refs., 6 figs., 1 tab. (Author)

  8. Assessment of RELAP5/MOD3 with condensation experiment for pure steam condensation in a vercal tube

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sang Jae; No, Hee Cheon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1998-12-31

    The film condensation models in RELAP5/MOD3.1 and RELAP5/MOD3.2 are assessed with the data of experiment performed in the scaled down condensation experimental facility with a single vertical tube of inner diameter of 46 mm in the range of pressure 0.1 {approx} 7.5 MPa for the PSCS(Passive Secondary Condenser System). Both MOD3.1 and MOD3.2 don`t shows any reliable predictions of the experimental data. The RELAP5/MOD3.1 overpredicts the heat transfer coefficients of experiment, whereas the RELAP5/MOD3.2 underpredicts those data. It is recommended that the film condensation model in RELAP5/MOD3.2 should be modified to have a larger heat transfer coefficient than those of the present model to give the reliable predictions. 7 refs., 6 figs., 1 tab. (Author)

  9. KONVENCIJE MOD O PRISILNEM DELU V LUČI DANAŠNJEGA ČASA

    OpenAIRE

    Kokoravec, Mateja

    2015-01-01

    Prisilno delo je antiteza dostojnega dela, za katerega se zavzema MOD. Za 21 milijonov ljudi to ni samo bled spomin iz preteklosti, ampak težka realnost še danes. Mednarodni delovni standardi, ki jih oblikuje MOD, predstavljajo temeljne minimalne socialne standarde, dogovorjene s strani glavnih udeležencev v svetovnem gospodarstvu. Z njimi si MOD prizadeva doseči dostojne delovne pogoje, saj je v današnjem svetu globalizacije za doseganje teh ciljev potrebno ukrepanje na mednarodni ravni. ...

  10. The LHCD Launcher for Alcator C-Mod - Design, Construction, Calibration and Testing

    International Nuclear Information System (INIS)

    Hosea, J.; Beals, D.; Beck, W.; Bernabei, S.; Burke, W.; Childs, R.; Ellis, R.; Fredd, E.; Greenough, N.; Grimes, M.; Gwinn, D.; Irby, J.; Jurczynski, S.; Koert, P.; Kung, C.C.; Loesser, G.D.; Marmar, E.; Parker, R.; Rushinski, J.; Schilling, G.; Terry, D.; Vieira, R.; Wilson, J.R.; Zaks, J.

    2005-01-01

    MIT and PPPL have joined together to fabricate a high-power lower hybrid current drive (LHCD) system for supporting steady-state AT regime research on Alcator C-Mod. The goal of the first step of this project is to provide 1.5 MW of 4.6 GHz rf [radio frequency] power to the plasma with a compact launcher which has excellent spectral selectivity and fits into a single C-Mod port. Some of the important design, construction, calibration and testing considerations for the launcher leading up to its installation on C-Mod are presented here

  11. Comparison of SCDAP/RELAP5/MOD3 to TRAC-PF1/MOD1 for timing analysis of PWR fuel pin failures

    International Nuclear Information System (INIS)

    Jones, K.R.; Katsma, K.R.; Wade, N.L.; Siefken, L.J.; Straka, M.

    1991-01-01

    A comparison has been made of SCDAP/RELAP5/MOD3- and TRAC-PF1/MOD1- based calculations of the fuel pin failure timing (time from containment isolation signal to first fuel pin failure) in a loss-of-coolant accident (LOCA). The two codes were used to calculate the thermal-hydraulic boundary conditions for a complete, double-ended, offset-shear break of a cold leg in a Westinghouse 4-loop pressurized water reactor. Both calculations used the FRAPCON-2 code to calculate the steady-state fuel rod behavior and the FRAP-T6 code to calculate the transient fuel rod behavior. The analysis was performed for 16 combinations of fuel burnups and power peaking factors extending up to the Technical Specifications limits. While all calculations were made on a best-estimate basis, the SCDAP/RELAP5/MOD3 code has not yet been fully assessed for large-break LOCA analysis. The results indicate that SCDAP/RELAP5/MOD3 yields conservative fuel pin failure timing results in comparison to those generated using TRAC-PF1/MOD1. 7 refs., 5 figs

  12. Biomonitoring of genotoxic risk in radar facility workers: comparison of the comet assay with micronucleus assay and chromatid breakage assay

    International Nuclear Information System (INIS)

    Garaj-Vrhovac, V.; Kopjar, N.

    2003-01-01

    Genotoxic risks of occupational exposure in a radar facility were evaluated by using alkaline comet assay, micronucleus assay and chromatid breakage assay on peripheral blood leukocytes in exposed subjects and corresponding controls. Results show that occupational exposure to microwave radiation correlates with an increase of genome damage in somatic cells. The levels of DNA damage in exposed subjects determined by using alkaline comet assay were increased compared to control and showed interindividual variations. Incidence of micronuclei was also significantly increased compared to baseline control values. After short exposure of cultured lymphocytes to bleomycin, cells of occupationally exposed subjects responded with high numbers of chromatid breaks. Although the level of chromosome damage generated by bleomycin varied greatly between individuals, in exposed subjects a significantly elevated number of chromatid breaks was observed. Our results support data reported in literature indicating that microwave radiation represents a potential DNA-damaging hazard. Alkaline comet assay is confirmed as a sensitive and highly reproducible technique for detection of primary DNA damage inflicted in somatic cells. Micronucleus assay was confirmed as reliable bio-markers of effect and chromatid breakage assay as sensitive bio-marker of individual cancer susceptibility. The results obtained also confirm the necessity to improve measures and to perform accurate health surveillance of individuals occupationally exposed to microwave radiation

  13. Bascule d'un modèle poutre à un modèle 3D en dynamique des machines tournantes

    OpenAIRE

    Tannous , Mikhael; Cartraud , Patrice; Dureisseix , David; Torkhani , Mohamed

    2013-01-01

    National audience; Les problèmes de machines tournantes incluant un contact rotor-stator, nécessitent un maillage 3D de la zone de contact. Cependant, un modèle 3D pour toute la durée de simulation conduit à des temps de calcul rédhibitoires. Or un modèle poutre est suffisant pour décrire la dynamique de la machine tournante hors contact. Une stratégie qui permet d'utiliser un modèle poutre et un autre 3D, pendant deux phases différentes durant la même simulation, permet donc de gagner en tem...

  14. Primes of the form x2 + dy2 with x ≡ 0(mod N)

    Indian Academy of Sciences (India)

    A Mersenne prime Mp = 2p −1 is a quadratic residue of 7 if and only if p ≡ 1(mod 3). In such cases Mp ≡ 1(mod 7) ... if the norm of Mp,α is a rational prime, then Mp,α is a quadratic residue of 7. Then it is proved that, for ..... [13] Vaugham T P, The construction of unramified cyclic quartic extension of Q(. √ m),. Math. Comput.

  15. Twenty Years of Research on the Alcator C-Mod Tokamak

    Science.gov (United States)

    Greenwald, Martin

    2013-10-01

    Alcator C-Mod is a compact, high-field tokamak, whose unique design and operating parameters have produced a wealth of new and important results since its start in 1993, contributing data that extended tests of critical physical models into new parameter ranges and into new regimes. Using only RF for heating and current drive with innovative launching structures, C-Mod operates routinely at very high power densities. Research highlights include direct experimental observation of ICRF mode-conversion, ICRF flow drive, demonstration of Lower-Hybrid current drive at ITER-like densities and fields and, using a set of powerful new diagnostics, extensive validation of advanced RF codes. C-Mod spearheaded the development of the vertical-target divertor and has always operated with high-Z metal plasma facing components--an approach adopted for ITER. C-Mod has made ground-breaking discoveries in divertor physics and plasma-material interactions at reactor-like power and particle fluxes and elucidated the critical role of cross-field transport in divertor operation, edge flows and the tokamak density limit. C-Mod developed the I-mode and EDA H-mode regimes which have high performance without large ELMs and with pedestal transport self-regulated by short-wavelength electromagnetic waves. C-Mod has carried out pioneering studies of intrinsic rotation and found that self-generated flow shear can be strong enough to significantly modify transport. C-Mod made the first quantitative link between pedestal temperature and H-mode performance, showing that the observed self-similar temperature profiles were consistent with critical-gradient-length theories and followed up with quantitative tests of nonlinear gyrokinetic models. Disruption studies on C-Mod provided the first observation of non-axisymmetric halo currents and non-axisymmetric radiation in mitigated disruptions. Work supported by U.S. DoE

  16. Three-dimensional Simulation of Gas Conductance Measurement Experiments on Alcator C-Mod

    International Nuclear Information System (INIS)

    Stotler, D.P.; LaBombard, B.

    2004-01-01

    Three-dimensional Monte Carlo neutral transport simulations of gas flow through the Alcator C-Mod subdivertor yield conductances comparable to those found in dedicated experiments. All are significantly smaller than the conductance found with the previously used axisymmetric geometry. A benchmarking exercise of the code against known conductance values for gas flow through a simple pipe provides a physical basis for interpreting the comparison of the three-dimensional and experimental C-Mod conductances

  17. Control of internal transport barriers on Alcator C-Mod

    International Nuclear Information System (INIS)

    Fiore, C.L.; Bonoli, P.T.; Ernst, D.R.; Hubbard, A.E.; Greenwald, M.J.; Lynn, A.; Marmar, E.S.; Phillips, P.; Redi, M.H.; Rice, J.E.; Wolfe, S.M.; Wukitch, S.J.; Zhurovich, K.

    2004-01-01

    Recent studies of internal transport and double transport barrier regimes in the Alcator C-Mod [I. H. Hutchinson et al., Phys. Plasmas 1, 1511 (1994)] have explored the limits for forming, maintaining, and controlling these plasmas. The C-Mod provides a unique platform for studying such discharges: the ions and electrons are tightly coupled by collisions and the plasma has no internal particle or momentum sources. The double-barrier mode comprised of an edge barrier with an internal transport barrier (ITB) can be induced at will using off-axis ion cyclotron range of frequency (ICRF) injection on either the low or high field side of the plasma with either of the available ICRF frequencies (70 or 80 MHz). When an enhanced D α high confinement mode (EDA H-mode) is accessed in Ohmic plasmas, the double barrier ITB forms spontaneously if the H-mode is sustained for ∼2 energy confinement times. The ITBs formed in both Ohmic and ICRF heated plasmas are quite similar regardless of the trigger method. They are characterized by strong central peaking of the electron density, and a reduction of the core particle and energy transport. The control of impurity influx and heating of the core plasma in the presence of the ITB have been achieved with the addition of central ICRF power in both the Ohmic H-mode and ICRF induced ITBs. The radial location of the particle transport barrier is dependent on the toroidal magnetic field but not on the location of the ICRF resonance. A narrow region of decreased electron thermal transport, as determined by sawtooth heat pulse analysis, is found in these plasmas as well. Transport analysis indicates that a reduction of the particle diffusivity in the barrier region allows the neoclassical pinch to drive the density and impurity accumulation in the plasma center. An examination of the gyrokinetic stability at the trigger time for the ITB suggests that the density and temperature profiles are inherently stable to ion temperature gradient and

  18. International Code Assessment and Applications Program: Summary of code assessment studies concerning RELAP5/MOD2, RELAP5/MOD3, and TRAC-B

    International Nuclear Information System (INIS)

    Schultz, R.R.

    1993-12-01

    Members of the International Code Assessment Program (ICAP) have assessed the US Nuclear Regulatory Commission (USNRC) advanced thermal-hydraulic codes over the past few years in a concerted effort to identify deficiencies, to define user guidelines, and to determine the state of each code. The results of sixty-two code assessment reviews, conducted at INEL, are summarized. Code deficiencies are discussed and user recommended nodalizations investigated during the course of conducting the assessment studies and reviews are listed. All the work that is summarized was done using the RELAP5/MOD2, RELAP5/MOD3, and TRAC-B codes

  19. NetMOD version 1.0 user's manual

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-01-01

    NetMOD (Network Monitoring for Optimal Detection) is a Java-based software package for conducting simulation of seismic networks. Specifically, NetMOD simulates the detection capabilities of seismic monitoring networks. Network simulations have long been used to study network resilience to station outages and to determine where additional stations are needed to reduce monitoring thresholds. NetMOD makes use of geophysical models to determine the source characteristics, signal attenuation along the path between the source and station, and the performance and noise properties of the station. These geophysical models are combined to simulate the relative amplitudes of signal and noise that are observed at each of the stations. From these signal-to-noise ratios (SNR), the probability of detection can be computed given a detection threshold. This manual describes how to configure and operate NetMOD to perform seismic detection simulations. In addition, NetMOD is distributed with a simulation dataset for the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) International Monitoring System (IMS) seismic network for the purpose of demonstrating NetMOD's capabilities and providing user training. The tutorial sections of this manual use this dataset when describing how to perform the steps involved when running a simulation.

  20. Assessment and improvement of condensation models in RELAP5/MOD3.2

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Ki Yong; Park, Hyun Sik; Kim, Sang Jae; No, Hee Chen [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1997-12-31

    The condensation models in the standard RELAP5/MOD3.2 code are assessed and improved based on the database, which is constructed from the previous experimental data on various condensation phenomena. The default model of the laminar film condensation in RELAP5/MOD3.2 does not give any reliable predictions, and its alternative model always predicts higher values than the experimental data. Therefore, it is needed to develop a new correlation based on the experimental data of various operating ranges in the constructed database. The Shah correlation, which is used to calculate the turbulent film condensation heat transfer coefficients in the standard RELAP5/MOD3.2, well predicts the experimental data in the database. The horizontally stratified condensation model of RELAP5/MOD3.2 overpredicts both cocurrent and countercurrent experimental data. The correlation proposed by H.J.Kim predicts the database relatively well compared with that of RELAP6/MOD3.2. The RELAP5/MOD3.2 model should use the liquid velocity for the calculation of the liquid Reynolds number and be modified to consider the effects of the gas velocity and the film thickness. 2 refs., 5 figs., 1 tab. (Author)

  1. Assessment and improvement of condensation models in RELAP5/MOD3.2

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Ki Yong; Park, Hyun Sik; Kim, Sang Jae; No, Hee Chen [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1998-12-31

    The condensation models in the standard RELAP5/MOD3.2 code are assessed and improved based on the database, which is constructed from the previous experimental data on various condensation phenomena. The default model of the laminar film condensation in RELAP5/MOD3.2 does not give any reliable predictions, and its alternative model always predicts higher values than the experimental data. Therefore, it is needed to develop a new correlation based on the experimental data of various operating ranges in the constructed database. The Shah correlation, which is used to calculate the turbulent film condensation heat transfer coefficients in the standard RELAP5/MOD3.2, well predicts the experimental data in the database. The horizontally stratified condensation model of RELAP5/MOD3.2 overpredicts both cocurrent and countercurrent experimental data. The correlation proposed by H.J.Kim predicts the database relatively well compared with that of RELAP6/MOD3.2. The RELAP5/MOD3.2 model should use the liquid velocity for the calculation of the liquid Reynolds number and be modified to consider the effects of the gas velocity and the film thickness. 2 refs., 5 figs., 1 tab. (Author)

  2. NetMOD Version 2.0 User?s Manual.

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    NetMOD ( Net work M onitoring for O ptimal D etection) is a Java-based software package for conducting simulation of seismic, hydracoustic, and infrasonic networks. Specifically, NetMOD simulates the detection capabilities of monitoring networks. Network simulations have long been used to study network resilience to station outages and to determine where additional stations are needed to reduce monitoring thresholds. NetMOD makes use of geophysical models to determine the source characteristics, signal attenuation along the path between the source and station, and the performance and noise properties of the station. These geophysical models are combined to simulate the relative amplitudes of signal and noise that are observed at each of the stations. From these signal-to-noise ratios (SNR), the probability of detection can be computed given a detection threshold. This manual describes how to configure and operate NetMOD to perform detection simulations. In addition, NetMOD is distributed with simulation datasets for the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) International Monitoring System (IMS) seismic, hydroacoustic, and infrasonic networks for the purpose of demonstrating NetMOD's capabilities and providing user training. The tutorial sections of this manual use this dataset when describing how to perform the steps involved when running a simulation. ACKNOWLEDGEMENTS We would like to thank the reviewers of this document for their contributions.

  3. MOD-5A wind turbine generator program design report: Volume 1: Executive Summary

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator covering work performed between July 1980 and June 1984 is discussed. The report is divided into four volumes: Volume 1 summarizes the entire MOD-5A program, Volume 2 discusses the conceptual and preliminary design phases, Volume 3 describes the final design of the MOD-5A, and Volume 4 contains the drawings and specifications developed for the final design. Volume 1, the Executive Summary, summarizes all phases of the MOD-5A program. The performance and cost of energy generated by the MOD-5A are presented. Each subsystem - the rotor, drivetrain, nacelle, tower and foundation, power generation, and control and instrumentation subsystems - is described briefly. The early phases of the MOD-5A program, during which the design was analyzed and optimized, and new technologies and materials were developed, are discussed. Manufacturing, quality assurance, and safety plans are presented. The volume concludes with an index of volumes 2 and 3.

  4. Susceptibility of pathogenic and nonpathogenic Naegleria ssp

    International Nuclear Information System (INIS)

    Whiteman, L.Y.

    1988-01-01

    The susceptibility of four species of Naegleria amoebae to complement-mediated lysis was determined. The amoebicidal activity of normal human serum (NHS) and normal guinea pig serum (NGPS) for Naegleria amoebae was measured by an in vitro cytotoxicity assay. Release of radioactivity from amoebae labeled with 3 H-uridine and visual observation with a compound microscope were used as indices of lysis. Susceptibility or resistance to complement-mediated lysis in vitro correlated with the in vivo pathogenic potential. Nonpathogenic Naegleria amoebae were lysed at a faster rate and at higher cell concentrations than were pathogenic amoebae. Electrophoretic analysis of NHS incubated with pathogenic or nonpathogenic Naegleria spp. demonstrated that amoebae activate the complement cascade resulting in the production of C3 and C5 complement cleavage products. Treatment with papain or trypsin for 1 h, but not with sialidase, increase the susceptibility of highly pathogenic, mouse-passaged N. fowleri to lysis. Treatment with actinomycin D, cycloheximide or various protease inhibitors for 4 h did not increase susceptibility to lysis. Neither a repair process involving de novo protein synthesis nor a complement-inactivating protease appear to account for the increase resistance of N. fowleri amoebae to complement-mediated lysis. A binding study with 125 I radiolabeled C9 indicated that the terminal complement component does not remain stably bound to the membrane of pathogenic amoebae

  5. CONTEMPT4/MOD2: a multicompartment containment system analysis program

    International Nuclear Information System (INIS)

    Metcalfe, L.J.; Mings, W.J.; Hartman, J.E.; Crail, A.C.

    1978-02-01

    CONTEMPT4/MOD2 is a digital computer program, written in FORTRAN IV, which describes the behavior of multicompartment pressurized water reactor (PWR) containment systems and experimental containment systems subjected to postulated loss-of-coolant accident (LOCA) conditions. The program calculates the time variation of compartment pressures, temperatures, mass and energy inventories, heat structure temperature distributions, and intercompartment mass and energy exchange based on user-supplied values for compartment descriptions, time step and edit controls, and selected problem features. Analytical models available to describe containment systems include models for containment fans and pumps, cooling sprays, fan coolers, heat conducting structures, sump drain, and PWR ice condensers. Dynamic storage allocations (DSA) is used to limit the amount of computer core used for each problem. Optional automatic time step control allows the code to determine time step sizes within limits dictated by the user. Multicompartment capability (up to 999 individual compartments) and generalized, user-oriented input data descriptions permit improved flexibility over previous codes in the CONTEMPT series. Analytical model descriptions, input instructions, and sample problem results are presented

  6. CONTEMPT 4/MOD 3: a multicompartment containment system analysis program

    International Nuclear Information System (INIS)

    Cheng, T.C.; Metcalfe, L.J.; Hartman, J.E.; Mings, W.J.; Crail, A.C.

    1982-12-01

    CONTEMPT4/MOD3 is a digital computer program, written in FORTRAN IV, that describes the behavior of multicompartment pressurized water reactor (PWR) containment systems and experimental containment systems subjected to postulated loss-of-coolant accident (LOCA) conditons. The program calculates the time variation of compartment pressures, temperatures, mass and energy inventories, heat structure temperature distributions, and intercompartment mass and energy exchange based on user-supplied values for compartment descriptions, time step and edit controls, and selected problem features. Analytical models available to describe containment systems include models for containment fans and pumps, cooling sprays, fan coolers, heat-conducting structures, sump drains, and PWR ice condensers. Dynamic stroage allocation (DSA) is used to limit the amount of computer core used for each problem. Optional automatic time step control allows the code to determine time step sizes within limits dictated by the user. Multicompartment capability (up to 999 individual compartments) and generalized, user-oriented input-data descriptions permit improved flexibility over previous codes in the CONTEMPT series. Analytical model descriptions, input instructions, and sample problem results are presented

  7. Neutral particle diagnostics for ALCATOR C-Mod

    International Nuclear Information System (INIS)

    Kurz, C.; Fiore, C.L.

    1990-01-01

    The ALCATOR C-Mod experiment will be equipped with two PPPL charge exchange neutral particle analyzers (CENAs), one of which views the plasma tangentially (R tan /R 0 =1.05), whereas the second has a horizontally scannable sight line (0≤R tan /R 0 ≤0.51). The perpendicularly viewing CENA will be capable of analyzing neutrals up to 600 keV amu for up to three separate species simultaneously. Thus high-energy tails can be observed together with the bulk ion temperature. The operation of both analyzers will allow simultaneous measurements from both the perpendicular and tangential chords. The CENAs will be used to study the effect of ICRF heating on the ion energy distribution with emphasis on the high-energy tail. A Fokker--Planck code (FPPRF) [Hammett, Ph.D. thesis, Princeton (1986)] is used to assess the appropriate operating regime of the analyzer (n≤4x10 20 m -3 for T i =2 keV, for Maxwellian ion energy distribution). The experimental design and computer simulations will be detailed

  8. Overview of Recent Alcator C-Mod Highlights

    Science.gov (United States)

    Marmar, Earl; C-Mod Team

    2013-10-01

    Analysis and modeling of recent C-Mod experiments has yielded significant results across multiple research topics. I-mode provides routine access to high confinement plasma (H98 up to 1.2) in quasi-steady state, without large ELMs; pedestal pressure and impurity transport are regulated by short-wavelength EM waves, and core turbulence is reduced. Multi-channel transport is being investigated in Ohmic and RF-heated plasmas, using advanced diagnostics to validate non-linear gyrokinetic simulations. Results from the new field-aligned ICRF antenna, including significantly reduced high-Z metal impurity contamination, and greatly improved load-tolerance, are being understood through antenna-plasma modeling. Reduced LHCD efficiency at high density correlates with parametric decay and enhanced edge absorption. Strong flow drive and edge turbulence suppression are seen from LHRF, providing new approaches for plasma control. Plasma density profiles directly in front of the LH coupler show non-linear modifications, with important consequences for wave coupling. Disruption-mitigation experiments using massive gas injection at multiple toroidal locations show unexpected results, with potentially significant implications for ITER. First results from a novel accelerator-based PMI diagnostic are presented. What would be the world's first actively-heated high-temperature advanced tungsten divertor is designed and ready for construction. Conceptual designs are being developed for an ultra-advanced divertor facility, Alcator DX, to attack key FNSF and DEMO heat-flux challenges integrated with a high-performance core. Supported by USDOE.

  9. Flux pinning in MOD YBCO films by chemical doping

    International Nuclear Information System (INIS)

    Zhou, Y X; Ghalsasi, S; Rusakova, I; Salama, K

    2007-01-01

    A novel nanomaterial synthesis technique has been developed to introduce 0D (particles), 1D (columnar defects) and 3D (domains) nanoscale pinning centres in MOD Y 1 Ba 2 Cu 3 O 7 (YBCO) coated conductors. We have succeeded in introducing nanoscale Y enriched particles, nanoscale 90 0 rotated Y 1/3 Sm 2/3 Ba 2 Cu 3 O 7 domains and nanoscale Zr enriched columnar defects into YBCO layers by different chemical doping. The pinning force density in Y 2 O 3 -doped YBCO film is found to be larger than that of pure YBCO film at all fields. Also it was found that YBCO films with Sm substituting for Y have yielded improved critical current density characteristics over a wide range of magnetic fields. Maximum pinning force densities exceeding 7 and 8 GN m -3 are obtained in 5% BZO-doped and Sm substituted YBCO films, respectively. Additionally, TEM studies revealed nanoscale Zr enriched columnar defects distributing in the matrix of the c-oriented YBCO film throughout the whole cross section. This indicates that chemical doping is a promising fabrication technique to create specific pinning landscapes in YBCO coated conductors

  10. Overview of the Alcator C-MOD Research Program

    International Nuclear Information System (INIS)

    Scott; S.; Bader, A.; Bakhtiari, M.; Basse, N.; Beck, W.; Biewer, T.; Bernabei, S.; Bonoli, P.

    2007-01-01

    Recent research on the high-field, high-density diverted Alcator C-MOD tokamak has focused on the plasma physics and plasma engineering required for ITER and for attractive fusion reactors. Experimental campaigns over the past two years have focused on understanding the physical mechanisms that affect the plasma performance realized with all-molybdenum walls versus walls with low-Z coatings. RF sheath rectification along flux tubes that intersect the RF antenna is found to be a major cause of localized boron erosion and impurity generation. Initial lower-hybrid current drive (LHCD) experiments (PLH p ∼ 1.0 MA with good efficiency, I drive = 0.4P LH /n eo R (MA,MW, 10 20 m -3 ,m). Disruption mitigation via massive gas-jet impurity puffing has proven successful at high plasma pressure, indicating this technique has promise for implementation on ITER. Pressure gradients in the near SOL of Ohmic L-mode plasmas are observed to scale consistently as I p 2 , and show a significant dependence on X-point topology. Modeling of H-mode edge fueling indicates high self-screening to neutrals in the pedestal and scrape-off layer (SOL), and reproduces experimental density pedestal response to changes in neutral source. Detailed measurements of the temperature and density profiles in the near sol and fast framing movies of the turbulent structures provide improved understanding of the mechanisms that control transport in the edge region.

  11. TRAC-PF1/MOD1 computer code

    International Nuclear Information System (INIS)

    Liles, D.R.; Mahaffy, J.H.

    1984-01-01

    The TRAC-P1 program was designed primarily for the analysis of large-break loss-of-coolant accidents (LOCAs) in pressurized water reactors (PWRs). Because of its versatility, however, it can be applied directly to many analyses ranging from blowdowns in simple pipes to integral LOCA tests in multiloop facilities. A refined version, called TRAC-P1A, was released to the National Energy Software Center (NESC) in March 1979. Although it still treats the same class of problems, TRAC-P1A is more efficient than TRAC-P1 and incorporates improved hydrodynamic and heat-transfer models. It also is easier to implement on various computers. TRAC-PD2 contains improved reflood and heat-transfer models and improvements in the numerical solution methods. Although a large LOCA code, it has been applied successfully to small-break problems and to the Three Mile Island incident. Distinguishing characteristics of the TRAC-PF1/MOD1 are summarized

  12. TRAC-PF1/MOD1 computer code

    International Nuclear Information System (INIS)

    Liles, D.R.; Mahaffy, J.H.

    1983-01-01

    TRAC-PF1 was designed to improve the ability of TRAC-PD2 to handle small-break LOCAs and other transients. TRAC-PF1 has all of the major improvements of TRAC-PD2 but, in addition, uses a full two-fluid model with two-step numerics in the one-dimensional components. The two-fluid model, in conjunction with a stratified-flow regime, handles countercurrent flow better than the drift-flux model previously used. The two-step numerics allow large time steps to be taken for slow transients. TRAC-PF1/MOD1 was designed to provide full balance-of-plant modeling capabilities. This required addition of a general capability for modeling plant control systems. The steam generator model was replaced to allow a wider variety of feedwater connections and better modeling of steam tube ruptures. A special turbine component also has been added, but new components were not required for adequate modeling of condensors, heaters, and pumps in the secondary system

  13. Transport of light, trace impurities in Alcator C-Mod

    Science.gov (United States)

    Rowan, W. L.; Bespamyatnov, I. O.; Liao, K. T.; Horton, W.; Fu, X. R.; Hughes, J. W.

    2012-10-01

    Light impurity profiles for boron were measured in ITB, H-mode, L-mode, and I-mode discharges in Alcator C-Mod. Within this wide range of modes, the profiles varied from peaked to hollow to flat. Specifically, hollow profiles are often observed in H-mode, while ITBs produce strong peaking, and L-mode produces moderate peaking. I-mode discharges are characterized by flat impurity profiles. For the study reported here, the profiles were measured with charge exchange recombination spectroscopy. The dependences of Rv/D were sought on dimensionless quantities including ion density scale length, effective charge, collisionality, and temperature scale length. We find that neoclassical transport consistently underestimates the measured transport. The excess measured transport is assumed to be turbulent. The strongest dependence of Rv/D is with temperature scale length. In addition, the measured transport was compared with the prediction of an analytical theory of drift wave turbulence that identifies transport implications for drift waves driven by ion and impurity density gradients.

  14. Highlights of the Alcator C-Mod Research Campaign

    Science.gov (United States)

    Greenwald, Martin; Alcator Team

    2011-10-01

    Alcator C-Mod has completed an experimental campaign focusing on broad scientific issues with particular emphasis on ITER needs and requests. Experiments with no NBI torque have investigated spontaneous flow reversal, creation of transport barriers aided by the shear of intrinsic rotation and a variety of RF flow drive schemes. Studies of I-mode have found conditions where a wide operating regime opens up, allowing easy access to long-lived, high-performance discharges with L-mode like particle confinement. We are validating the EPED and BOUT++ models for pedestal height/width and ELM onset using extended parameter scans in ELMy H-mode. The challenge of high-Z impurity generation with ICRF is being addressed first by deployment of a novel antenna whose current straps and antenna box are perpendicular to the total magnetic field -second by studies of the modification of edge impurity transport, where fine-scale Er structures in the SOL in the presence of ICRF heating have been found. LH current drive has produced non-inductive reversed shear regimes at n ~ 5x1019 which exhibit electron temperature ITBs. The first observations have been made of in-tokamak production of divertor tungsten nano-structures (fuzz), which had previously been seen only in linear laboratory experiments. Supported by DoE DE-FC02-99ER54512.

  15. Dissipative divertor operation in the Alcator C-Mod tokamak

    International Nuclear Information System (INIS)

    Lipschultz, B.; Goetz, J.; LaBombard, B.; McCracken, G.M.; Terry, J.L.; Graf, M.; Granetz, R.S.; Jablonski, D.; Kurz, C.; Niemczewski, A.; Snipes, J.

    1995-01-01

    The achievement of large volumetric power losses (dissipation) in the Alcator C-Mod divertor region is demonstrated in two operational modes: radiative divertor and detached divertor. During radiative divertor operation, the fraction of SOL power lost by radiation is P R /P SOL ∼0.8 with single null plasmas, n e 20 m -3 and I p e,div ≤6x10 20 m -3 . As the divertor radiation and density increase, the plasma eventually detaches abruptly from the divertor plates: I SAT drops at the target and the divertor radiation peak moves to the X-point region. Probe measurements at the divertor plate show that the transition occurs when T e ∼5 eV. The critical n e for detachment depends linearly on the input power. This abrupt divertor detachment is preceded by a comparatively long period ( similar 1-200 ms) where a partial detachment is observed to grow at the outer divertor plate. ((orig.))

  16. Vacuum boundary modifications of the RFX-mod machine

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Nisarg, E-mail: nisarg.patel@igi.cnr.it [University of Padova,Via 8 Febbraio 2, Padova 35122 (Italy); Consorzio RFX, Corso StatiUniti 4, Padova 35127 (Italy); Dalla Palma, Mauro; Dal Bello, Samuele; Grando, Luca; Peruzzo, Simone [Consorzio RFX, Corso StatiUniti 4, Padova 35127 (Italy); Sonato, Piergiorgio [University of Padova,Via 8 Febbraio 2, Padova 35122 (Italy); Consorzio RFX, Corso StatiUniti 4, Padova 35127 (Italy)

    2016-11-01

    Highlights: • Different vacuum sealing solutions are designed for cuts of Toroidal Support Structure. • New supporting rings are designed for In-TSS components. • Identified integration of the sub-assemblies. • Thermo-mechanical behaviour of components are verified against standard design rules. - Abstract: The results produced by experimental campaigns of RFX-mod shows the need to improve passive MHD control and minimise braking torque on plasma. These improvements require major mechanical changes on the present components of the machine including first wall, vacuum vessel, and toroidal support structure (TSS). The vacuum vessel will be removed and the first wall tiles will be directly supported by the passive stabilising shell, so increasing the poloidal cross section by 28 mm radially and bringing the passive stabilising shell as close as possible to the plasma boundary. This paper presents the mechanical design modifications of the torus assembly. Composite rings are designed to support the passive stabilising shell on the TSS. The vacuum boundary is shifted at the TSS by developing different joint solutions compatible with the stringent requirements of the present components: ceramic-metal brazed rings at the two poloidal joints, fully welded solution at the external equatorial joint, and resistive weld plate at the internal equatorial joint. The vacuum vessel portholes for pumping, fuelling, diagnostics, and sensor cable routing are redesigned to be integrated onto the TSS. The design is supported by thermo-mechanical analyses and verifications carried out applying load combinations corresponding to the expected load cases.

  17. Active MHD control experiments in RFX-mod

    International Nuclear Information System (INIS)

    Ortolani, Sergio

    2006-01-01

    The RFX reversed field pinch experiment has been modified (RFX-mod) to address specific issues of active control of MHD instabilities. A thin shell (τ Bv ∼50 ms) has replaced the old thick one (τ Bv ∼500 ms) and 192 (4 poloidal x 48 toroidal) independently powered saddle coils surround the thin shell forming a cage completely covering the torus. This paper reports the results obtained during the first year of operation. The system has been used with various control scenarios including experiments on local radial field cancellation over the entire torus surface to mimic an ideal wall ('virtual shell') and on single and multiple mode feedback control. Successful virtual shell operation has been achieved leading to: a 3-fold increase in pulse length and well controlled 300 ms pulses(∼6 shell times) up to ∼1 MA plasma current; one order of magnitude reduction of the dominant radial field perturbations at the plasma edge and correspondingly 100% increase in global energy confinement time. Robust feedback stabilization of resistive wall modes has been demonstrated in conditions where rotation does not play a role and multiple unstable modes are present

  18. 3D effects on the RFX-mod boundary

    International Nuclear Information System (INIS)

    Vianello, N.; Spizzo, G.; Agostini, M.; Scarin, P.; Carraro, L.; Cavazzana, R.; De Masi, G.; Martines, E.; Momo, B.; Rea, C.; Spagnolo, S.; Spolaore, M.; Zuin, M.

    2013-01-01

    In present fusion research a strong effort is devoted to the studies of non-axisymmetric magnetic perturbations and consequent field ergodization on the external region of the plasma. On this topic interesting results can be drawn from the helical configuration observed in high-current regimes in reversed field pinches (RFPs) where the small edge helical ripple is sufficient to modulate the plasma–wall interaction and the plasma kinetic properties. This paper presents the most recent experimental results and physical interpretation of the phenomena observed in the edge region of the RFX-mod RFP device. Experimental observations indicate that plasma pressure and floating potential are spatially modulated according to the helical deformation. Helical flow is observed at the edge as a consequence of an ambipolar electric field. Emphasis will be devoted to the determination of the actual phase relation between magnetic perturbation and velocity perturbation. Evidence of the influence of the helical ripple on turbulence properties at the edge is also reported. (paper)

  19. Edge turbulence imaging in the Alcator C-Mod tokamak

    International Nuclear Information System (INIS)

    Zweben, S.J.; Stotler, D.P.; Terry, J.L.; La Bombard, B.; Greenwald, M.; Muterspaugh, M.; Pitcher, C.S.; Hallatschek, K.; Maqueda, R.J.; Rogers, B.; Lowrance, J.L.; Mastrocola, V.J.; Renda, G.F.

    2002-01-01

    The two-dimensional (2D) radial vs poloidal structure of edge turbulence in the Alcator C-Mod tokamak [I. H. Hutchinson, R. Boivin, P. T. Bonoli et al., Nucl. Fusion 41, 1391 (2001)] was measured using fast cameras and compared with three-dimensional numerical simulations of edge plasma turbulence. The main diagnostic is gas puff imaging, in which the visible D α emission from a localized D 2 gas puff is viewed along a local magnetic field line. The observed D α fluctuations have a typical radial and poloidal scale of ≅1 cm, and often have strong local maxima ('blobs') in the scrape-off layer. The motion of this 2D structure motion has also been measured using an ultrafast framing camera with 12 frames taken at 250 000 frames/s. Numerical simulations produce turbulent structures with roughly similar spatial and temporal scales and transport levels as that observed in the experiment; however, some differences are also noted, perhaps requiring diagnostic improvement and/or additional physics in the numerical model

  20. Genetic susceptibility of periodontitis

    NARCIS (Netherlands)

    Laine, M.L.; Crielaard, W.; Loos, B.G.

    2012-01-01

    In this systematic review, we explore and summarize the peer-reviewed literature on putative genetic risk factors for susceptibility to aggressive and chronic periodontitis. A comprehensive literature search on the PubMed database was performed using the keywords ‘periodontitis’ or ‘periodontal

  1. A modified MOD16 algorithm to estimate evapotranspiration over alpine meadow on the Tibetan Plateau, China

    Science.gov (United States)

    Chang, Y.; Ding, Y.; Zhao, Q.; Zhang, S.

    2017-12-01

    The accurate estimation of evapotranspiration (ET) is crucial for managing water resources in areas with extreme climates affected by climate change, such as the Tibetan Plateau (TP). The MOD16 ET product has also been validated and applied in many countries with various climates, however, its performance varies under different climates and regions. Several have studied ET based on satellite-based models on the TP. However, only a few studies on the performance of MOD16 in the TP with heterogeneous land cover have been reported. This study proposes an improved algorithm for estimating ET based on a proposed modified MOD16 method over alpine meadow on the TP in China. Wind speed and vegetation height were integrated to estimate aerodynamic resistance, while the temperature and moisture constraint for stomatal conductance were revised based on the technique proposed by Fisher et al. (2008). Moreover, Fisher's method for soil evaporation was introduced to decrease the uncertainty of soil evaporation estimation. Five representative alpine meadow sites on the TP were selected to investigate the performance of the modified algorithm. Comparisons between ET observed using Eddy Covariance (EC) and estimated using both the original method and modified method suggest that the modified algorithm had better performance than the original MOD16 method. This result was achieved considering that the coefficient of determination (R2) increased from 0.28 to 0.70, and the root mean square error (RMSE) decreased from 1.31 to 0.77 mm d-1. The modified algorithm also outperformed on precipitation days compared to non-precipitation days at Suli and Hulugou sites, while it performed well for both non-precipitation and precipitation days at Tanggula site. Comparisons of the 8-day ET estimation using the MOD16 product, original MOD16 method, and modified MOD16 method with observed ET suggest that MOD16 product underestimated ET over the alpine meadow of the TP during the growing season

  2. Microbead agglutination based assays

    KAUST Repository

    Kodzius, Rimantas

    2013-01-21

    We report a simple and rapid room temperature assay for point-of-care (POC) testing that is based on specific agglutination. Agglutination tests are based on aggregation of microbeads in the presence of a specific analyte thus enabling the macroscopic observation. Such tests are most often used to explore antibody-antigen reactions. Agglutination has been used for protein assays using a biotin/streptavidin system as well as a hybridization based assay. The agglutination systems are prone to selftermination of the linking analyte, prone to active site saturation and loss of agglomeration at high analyte concentrations. We investigated the molecular target/ligand interaction, explaining the common agglutination problems related to analyte self-termination, linkage of the analyte to the same bead instead of different microbeads. We classified the agglutination process into three kinds of assays: a two- component assay, a three-component assay and a stepped three- component assay. Although we compared these three kinds of assays for recognizing DNA and protein molecules, the assay can be used for virtually any molecule, including ions and metabolites. In total, the optimized assay permits detecting analytes with high sensitivity in a short time, 5 min, at room temperature. Such a system is appropriate for POC testing.

  3. Sur la modélisation des supraconducteurs : le ``modèle de l'état critique'' de Bean, en trois dimensions

    Science.gov (United States)

    Bossavit, A.

    1993-03-01

    Macroscopic modelling of superconductors demands a substitution of some nonlinear behavior law for Ohm's law. For this, a version of Bean's “critical state” model, derived from the setting of a convex functional of the current density field, valid in dimension 3 without any previous assumption about the direction of currents, is proposed. It is shown how two standard three-dimensional finite element methods (“h-formulation” and “e-formulation”), once fitted with this model, can deal with situations were superconductors are present. La modélisation macroscopique des supraconducteurs suppose le remplacement de la loi d'Ohm par une loi de comportement non linéaire adéquate. On présente à cet effet une version du “modèle de Bean”, ou modèle de l'état critique, basée sur la construction d'une certaine fonctionnelle convexe du champ des densités de courant, qui est valable en dimension 3 sans hypothèses préalables sur la direction des courants. On montre comment adapter deux méthodes standards de calcul de courants de Foucault par élérnents finis en trois dimensions (“en h” et “en e”) à la présence de supraconducteurs, en incorporant ce modèle.

  4. Genetic susceptibility of newborn daughters to oxidative stress

    DEFF Research Database (Denmark)

    Decordier, Ilse; De Bont, Kelly; De Bock, Kirsten

    2007-01-01

    A central question in risk assessment is whether newborns' susceptibility to mutagens is different from that of adults. Therefore we investigated whether genotype and/or the DNA strand break repair phenotype in combination with the MN assay would allow estimation of the relative sensitivity of a ...

  5. Radioreceptor opioid assay

    International Nuclear Information System (INIS)

    Miller, R.J.; Chang, K.-J.

    1981-01-01

    A radioreceptor assay is described for assaying opioid drugs in biological fluids. The method enables the assay of total opioid activity, being specific for opioids as a class but lacking specificity within the class. A radio-iodinated opioid and the liquid test sample are incubated with an opiate receptor material. The percentage inhibition of the binding of the radio-iodinated compound to the opiate receptor is calculated and the opioid activity of the test liquid determined from a standard curve. Examples of preparing radio-iodinated opioids and assaying opioid activity are given. A test kit for the assay is described. Compared to other methods, this assay is cheap, easy and rapid. (U.K.)

  6. Preliminary validation of RELAP5/Mod4.0 code for LBE cooled NACIE facility

    Energy Technology Data Exchange (ETDEWEB)

    Kumari, Indu; Khanna, Ashok, E-mail: akhanna@iitk.ac.in

    2017-04-01

    Highlights: • Detail discussion of thermo physical properties of Lead Bismuth Eutectic incorporated in the code RELAP5/Mod4.0 included. • Benchmarking of LBE properties in RELAP5/Mod4.0 against literature. • NACIE facility for three different power levels (10.8, 21.7 and 32.5 kW) under natural circulation considered for benchmarking. • Preliminary validation of the LBE properties against experimental data. • NACIE facility for power level 22.5 kW considered for validation. - Abstract: The one-dimensional thermal hydraulic computer code RELAP5 was developed for thermal hydraulic study of light water reactor as well as for nuclear research reactors. The purpose of this work is to evaluate the code RELAP5/Mod4.0 for analysis of research reactors. This paper consists of three major sections. The first section presents detailed discussions on thermo-physical properties of Lead Bismuth Eutectic (LBE) incorporated in RELAP5/Mod4.0 code. In the second section, benchmarking of RELAP5/Mod4.0 has been done with the Natural Circulation Experimental (NACIE) facility in comparison with Barone’s simulations using RELAP5/Mod3.3. Three different power levels (10.8 kW, 21.7 kW and 32.5 kW) under natural circulation conditions are considered. Results obtained for LBE temperatures, temperature difference across heat section, pin surface temperatures, mass flow rates and heat transfer coefficients in heat section heat exchanger are in agreement with Barone’s simulation results within 7% of average relative error. Third section presents validation of RELAP5/Mod4.0 against the experimental data of NACIE facility performed by Tarantino et al. test number 21 at power of 22.5 kW comparing the profiles of temperatures, mass flow rate and velocity of LBE. Simulation and experimental results agree within 7% of average relative error.

  7. Absolute nuclear material assay

    Science.gov (United States)

    Prasad, Manoj K [Pleasanton, CA; Snyderman, Neal J [Berkeley, CA; Rowland, Mark S [Alamo, CA

    2010-07-13

    A method of absolute nuclear material assay of an unknown source comprising counting neutrons from the unknown source and providing an absolute nuclear material assay utilizing a model to optimally compare to the measured count distributions. In one embodiment, the step of providing an absolute nuclear material assay comprises utilizing a random sampling of analytically computed fission chain distributions to generate a continuous time-evolving sequence of event-counts by spreading the fission chain distribution in time.

  8. Penicillin-susceptible Staphylococcus aureus: susceptibility testing, resistance rates and outcome of infection.

    Science.gov (United States)

    Hagstrand Aldman, Malin; Skovby, Annette; I Påhlman, Lisa

    2017-06-01

    Staphylococcus aureus (SA) is an important human pathogen that causes both superficial and invasive infections. Penicillin is now rarely used in the treatment of SA infections due to widespread resistance and a concern about the accuracy of existing methods for penicillin susceptibility testing. The aims of the present study were to determine the frequency of penicillin-susceptible SA isolates from blood and wound cultures in Lund, Sweden, and to evaluate methods for penicillin testing in SA. We also wanted to investigate if penicillin-susceptible isolates are associated with higher mortality. Hundred blood culture isolates collected 2008/2009, 140 blood culture isolates from 2014/2015, and 141 superficial wound culture strains from 2015 were examined. Penicillin susceptibility was tested with disk diffusion according to EUCAST guidelines, and results were confirmed with a cloverleaf assay and PCR amplification of the BlaZ gene. Patient data for all bacteraemia cases were extracted from medical records. The disk diffusion method with assessment of both zone size and zone edge appearance had high accuracy in our study. About 57% of bacteraemia isolates from 2008/2009 were sensitive to penicillin compared to 29% in 2014/2015 (p penicillin susceptible. There was no difference in co-morbidity or mortality rates between patients with penicillin resistant and penicillin sensitive SA bacteraemia. Disk-diffusion is a simple and reliable method to detect penicillin resistance in SA, and susceptibility rates are significant. Penicillin has many theoretical advantages and should be considered in the treatment of SA bacteraemia when susceptible.

  9. ModFOLD6: an accurate web server for the global and local quality estimation of 3D protein models.

    Science.gov (United States)

    Maghrabi, Ali H A; McGuffin, Liam J

    2017-07-03

    Methods that reliably estimate the likely similarity between the predicted and native structures of proteins have become essential for driving the acceptance and adoption of three-dimensional protein models by life scientists. ModFOLD6 is the latest version of our leading resource for Estimates of Model Accuracy (EMA), which uses a pioneering hybrid quasi-single model approach. The ModFOLD6 server integrates scores from three pure-single model methods and three quasi-single model methods using a neural network to estimate local quality scores. Additionally, the server provides three options for producing global score estimates, depending on the requirements of the user: (i) ModFOLD6_rank, which is optimized for ranking/selection, (ii) ModFOLD6_cor, which is optimized for correlations of predicted and observed scores and (iii) ModFOLD6 global for balanced performance. The ModFOLD6 methods rank among the top few for EMA, according to independent blind testing by the CASP12 assessors. The ModFOLD6 server is also continuously automatically evaluated as part of the CAMEO project, where significant performance gains have been observed compared to our previous server and other publicly available servers. The ModFOLD6 server is freely available at: http://www.reading.ac.uk/bioinf/ModFOLD/. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  10. Adhesion, biofilm formation, cell surface hydrophobicity, and antifungal planktonic susceptibility: relationship among Candida spp.

    OpenAIRE

    Silva-Dias, Ana; Miranda, Isabel M.; Branco, Joana; Monteiro-Soares, Matilde; Pina-Vaz, Cid?lia; Rodrigues, Ac?cio G.

    2015-01-01

    We have performed the characterization of the adhesion profile, biofilm formation, cell surface hydrophobicity (CSH) and antifungal susceptibility of 184 Candida clinical isolates obtained from different human reservoirs. Adhesion was quantified using a flow cytometric assay and biofilm formation was evaluated using two methodologies: XTT and crystal violet assay. CSH was quantified with the microbial adhesion to hydrocarbons test while planktonic susceptibility was assessed accordingly the C...

  11. Overview of recent Alcator C-Mod research

    International Nuclear Information System (INIS)

    Marmar, E.S.; Bai, B.; Boivin, R.L.

    2003-01-01

    Research on the Alcator C-Mod tokamak is focused on high particle- and power-density plasma regimes to understand particle and energy transport in the core, the dynamics of the H-mode pedestal, and scrape-off layer and divertor physics. The auxiliary heating is provided exclusively by RF waves, and both the physics and technology of RF heating and current drive are studied. The momentum which is manifested in strong toroidal rotation, in the absence of direct momentum input, has been shown to be transported in from the edge of the plasma following the L to H transition, with time scale comparable to that for energy transport. In discharges which develop internal transport barriers (ITBs), the rotation slows first inside the barrier region, and then subsequently outside of the barrier foot. Heat pulse propagation studies using sawteeth indicate a very narrow region of strongly reduced energy transport, located near r/a = 0.5. Addition of on-axis ICRF heating arrests the buildup of density and impurities, leading to quasi-steady conditions. The quasi-coherent mode associated with EDA H-mode appears to be due to a resistive ballooning instability. As the pedestal pressure gradient and temperature are increased in EDA H-mode, small ELMs appear; detailed modeling indicates that these are due to intermediate n peeling-ballooning modes. Phase Contrast Imaging (PCI) has been used to directly detect density fluctuations driven by ICRF waves in the core of the plasma, and mode conversion to an intermediate wavelength Ion Cyclotron Wave has been observed for the first time. The bursty turbulent density fluctuations, observed to drive rapid cross-field particle transport in the edge plasma, appear to play a key role the dynamics of the density limit. Preparations for quasi-steady-state Advanced Tokamak studies with lower hybrid current drive are well underway, and time dependent modeling indicates that regimes with high bootstrap fraction can be produced. (author)

  12. Measurement of particle transport coefficients on Alcator C-Mod

    International Nuclear Information System (INIS)

    Luke, T.C.T.

    1994-10-01

    The goal of this thesis was to study the behavior of the plasma transport during the divertor detachment in order to explain the central electron density rise. The measurement of particle transport coefficients requires sophisticated diagnostic tools. A two color interferometer system was developed and installed on Alcator C-Mod to measure the electron density with high spatial (∼ 2 cm) and high temporal (≤ 1.0 ms) resolution. The system consists of 10 CO 2 (10.6 μm) and 4 HeNe (.6328 μm) chords that are used to measure the line integrated density to within 0.08 CO 2 degrees or 2.3 x 10 16 m -2 theoretically. Using the two color interferometer, a series of gas puffing experiments were conducted. The density was varied above and below the threshold density for detachment at a constant magnetic field and plasma current. Using a gas modulation technique, the particle diffusion, D, and the convective velocity, V, were determined. Profiles were inverted using a SVD inversion and the transport coefficients were extracted with a time regression analysis and a transport simulation analysis. Results from each analysis were in good agreement. Measured profiles of the coefficients increased with the radius and the values were consistent with measurements from other experiments. The values exceeded neoclassical predictions by a factor of 10. The profiles also exhibited an inverse dependence with plasma density. The scaling of both attached and detached plasmas agreed well with this inverse scaling. This result and the lack of change in the energy and impurity transport indicate that there was no change in the underlying transport processes after detachment

  13. Measurement of particle transport coefficients on Alcator C-Mod

    Energy Technology Data Exchange (ETDEWEB)

    Luke, T.C.T.

    1994-10-01

    The goal of this thesis was to study the behavior of the plasma transport during the divertor detachment in order to explain the central electron density rise. The measurement of particle transport coefficients requires sophisticated diagnostic tools. A two color interferometer system was developed and installed on Alcator C-Mod to measure the electron density with high spatial ({approx} 2 cm) and high temporal ({le} 1.0 ms) resolution. The system consists of 10 CO{sub 2} (10.6 {mu}m) and 4 HeNe (.6328 {mu}m) chords that are used to measure the line integrated density to within 0.08 CO{sub 2} degrees or 2.3 {times} 10{sup 16}m{sup {minus}2} theoretically. Using the two color interferometer, a series of gas puffing experiments were conducted. The density was varied above and below the threshold density for detachment at a constant magnetic field and plasma current. Using a gas modulation technique, the particle diffusion, D, and the convective velocity, V, were determined. Profiles were inverted using a SVD inversion and the transport coefficients were extracted with a time regression analysis and a transport simulation analysis. Results from each analysis were in good agreement. Measured profiles of the coefficients increased with the radius and the values were consistent with measurements from other experiments. The values exceeded neoclassical predictions by a factor of 10. The profiles also exhibited an inverse dependence with plasma density. The scaling of both attached and detached plasmas agreed well with this inverse scaling. This result and the lack of change in the energy and impurity transport indicate that there was no change in the underlying transport processes after detachment.

  14. Design and Implementation of MOD-6 Synchronous Counter using VHDL

    Directory of Open Access Journals (Sweden)

    P. Y. Dibal

    2013-08-01

    Full Text Available This paper deals with the design of a MOD-6 synchronous counter using VHDL (VHSIC Hardware Description Language. The VHSIC stands for Very High Speed Integrated Circuit. Using this approach, the behaviour of the counter is the most important aspect of the design. In the first section, the paper introduced counters in general, and their areas of specialization, like frequency synthesizers. The synchronous counter was then introduced, stating the behaviour of the flip-flops that make the counter. The modulus of a counter was defined. In the second section, the Xilinx ISE (Integrated Simulation Environment and the ISIM (Integrated Simulator were presented and briefly described with their respective snapshots. The structure of a typical VHDL code was presented, which included LIBRARY, ENTITY, and ARCHITECTURE. Each of these structures was then briefly described. The main work in this paper was then presented. The count sequence steps were stated as . VHDL was used to model the counter to count through six steps, outputting count values according to desired steps. The hardware implementation of the design was presented, where the implementation process was described, with a supporting diagram, followed by the floor-planning technique, in which the PORTS described in the VHDL design were assigned to the physical pins of the XC3S1000 FPGA (Field Programmable Gate Array chip. The final steps of the hardware implementation process were then presented. These include bitstream generation and download to target device. The third section of the paper presented the results obtained. Simulation/timing results of the design were presented, showing the output of the counter at each state with respect to the clock signal. The result of the synthesis of the design was presented, which showed the FPGA area with the exact location of the pins on the FPGA chip. Finally, the fourth section presented the conclusion arrived at, in respect of the design that was carried

  15. Lower Hybrid Current Drive Experiments in Alcator C-Mod

    International Nuclear Information System (INIS)

    Wilson, J. R.; Bonoli, P.; Hubbard, A.; Parker, R.; Schmidt, A.; Wallace, G.; Wright, J.; Bernabei, S.

    2007-01-01

    A Lower Hybrid Current Drive (LHCD) system has been installed on the Alcator C-MOD tokamak at MIT. Twelve klystrons at 4.6 GHz feed a 4x22 waveguide array. This system was designed for maximum flexibility in the launched parallel wave-number spectrum. This flexibility allows tailoring of the lower hybrid deposition under a variety of plasma conditions. Power levels up to 900 kW have been injected into the tokomak. The parallel wave number has been varied over a wide range, n parallel ∼1.6-4. Driven currents have been inferred from magnetic measurements by extrapolating to zero loop voltage and by direct comparison to Fisch-Karney theory, yielding an efficiency of n 20 IR/P∼0.3. Modeling using the CQL3D code supports these efficiencies. Sawtooth oscillations vanish, accompanied with peaking of the electron temperature (T e0 rises from 2.8 to 3.8 keV). Central q is inferred to rise above unity from the collapse of the sawtooth inversion radius, indicating off-axis cd as expected. Measurements of non-thermal x-ray and electron cyclotron emission confirm the presence of a significant fast electron population that varies with phase and plasma density. The x-ray emission is observed to be radialy broader than that predicted by simple ray tracing codes. Possible explanations for this broader emission include fast electron diffusion or broader deposition than simple ray tracing predictions (perhaps due to diffractive effects)

  16. Transport mechanisms in the outer region of RFX-mod

    International Nuclear Information System (INIS)

    Vianello, N.; Martines, E.; Agostini, M.; Alfier, A.; Canton, A.; Cavazzana, R.; De Masi, G.; Fassina, A.; Lorenzini, R.; Scarin, P.; Serianni, G.; Spagnolo, S.; Spizzo, G.; Spolaore, M.; Zuin, M.

    2009-01-01

    Transport properties of the edge region of RFPs are characterized by complicated mechanisms further entangled by the complex magnetic topology. Recently on RFX-mod (Sonato 2003 Fusion Eng. Des. 66-68 161) the use of an efficient feedback system for MHD control allowed the achievement of an unprecedented plasma current for an RFP, of up to 1.6 MA, with an improvement in the confinement properties. This is accompanied by an amelioration of the magnetic boundary and the observation of different MHD regimes, moving from low current multiple helical regime, to high current quasi-single helical ones. At a low plasma current (I p ∼ 300-400 kA) in multiple helicity discharge the plasma parameter profiles at the edge are strongly influenced by the presence of m = 0 islands which flatten the temperature profile and modify substantially both the electric drift flow and the E x B shear. The particle diffusion coefficient and the thermal conductivity χ e in this regime are 10-20 m 2 s -1 and 100-200 m 2 s -1 , respectively. Both temperature and pressure characteristic scale lengths are found to scale favourably with the decrease in the secondary modes achieved through the increase in the plasma current. The same trend is observed for the thermal conductivity, and the recently discovered single helical axis states (Lorenzini et al 2008 Phys. Rev. Lett. 101 025005) exhibit an edge χ e reduced by a factor of up to 40%. Finally the perpendicular flow at the edge is found to scale with the density normalized to the Greenwald density with a saturation at values around n/n G ∼ 0.35.

  17. Excitation functions of the 98Mo+d reactions

    International Nuclear Information System (INIS)

    Zarubin, P.P.; Padalko, V.Yu.; Khrisanfov, Yu.V.; Lebedev, P.P.; Podkopaev, Yu.N.

    The excitation functions of the 98 Mo+d reactions were studied. The energy dependence of (d,p),(d,n) and (d,α) reactions was investigated by the activation analysis. The energies of deuterons in the range (6-12) MeV were determined by means of the aluminium filters. 98 Mo foils with surface densities of 1.02, 0.23 and 0.14 mgxcm -2 with 98 Mo enrichment of 94.1% were used as targets. The gamma spectra were measured by a Ge(Li) detector. The 98 Mo(d,p) 99 Mo reaction excitation function was determined via detection of 739 and 181 keV γ-radiation of 99 Mo (Tsub(1/2)=66.47h); 140 keV γ-radiation of 99 Tc (Tsub(1/2)=6h) was detected for the 98 Mo(d,n) 99 Tc reaction excitation function determination and 460, 568, 1091, 1200 and 1492 keV γ-quanta of 96 Nb (Tsub(1/2)=23.35h) - for the 98 Mo(d,α) 96 Nb reaction. In the excitation function the wide extremum was observed at Esub(d) approximately 10 MeV. The ratio of cross sections σsup(m)(d,n)/σ(d,p) on the 98 Mo target was determined. The ratio σsup(m)(d,n)/σ(d,p) was found to be decreasing function of the deuteron energy. The relative cross sections were determined with an accuracy of +-5%, while for the absolute values of cross sections the accuracy was +-15%

  18. 20 years of research on the Alcator C-Mod tokamak

    International Nuclear Information System (INIS)

    Greenwald, M.; Baek, S.; Barnard, H.; Beck, W.; Bonoli, P.; Brunner, D.; Burke, W.; Ennever, P.; Ernst, D.; Faust, I.; Fiore, C.; Fredian, T.; Gao, C.; Golfinopoulos, T.; Granetz, R.; Hartwig, Z.; Hubbard, A.; Hughes, J.; Hutchinson, I.; Irby, J.

    2014-01-01

    The object of this review is to summarize the achievements of research on the Alcator C-Mod tokamak [Hutchinson et al., Phys. Plasmas 1, 1511 (1994) and Marmar, Fusion Sci. Technol. 51, 261 (2007)] and to place that research in the context of the quest for practical fusion energy. C-Mod is a compact, high-field tokamak, whose unique design and operating parameters have produced a wealth of new and important results since it began operation in 1993, contributing data that extends tests of critical physical models into new parameter ranges and into new regimes. Using only high-power radio frequency (RF) waves for heating and current drive with innovative launching structures, C-Mod operates routinely at reactor level power densities and achieves plasma pressures higher than any other toroidal confinement device. C-Mod spearheaded the development of the vertical-target divertor and has always operated with high-Z metal plasma facing components—approaches subsequently adopted for ITER. C-Mod has made ground-breaking discoveries in divertor physics and plasma-material interactions at reactor-like power and particle fluxes and elucidated the critical role of cross-field transport in divertor operation, edge flows and the tokamak density limit. C-Mod developed the I-mode and the Enhanced Dα H-mode regimes, which have high performance without large edge localized modes and with pedestal transport self-regulated by short-wavelength electromagnetic waves. C-Mod has carried out pioneering studies of intrinsic rotation and demonstrated that self-generated flow shear can be strong enough in some cases to significantly modify transport. C-Mod made the first quantitative link between the pedestal temperature and the H-mode's performance, showing that the observed self-similar temperature profiles were consistent with critical-gradient-length theories and followed up with quantitative tests of nonlinear gyrokinetic models. RF research highlights include direct experimental

  19. 20 years of research on the Alcator C-Mod tokamaka)

    Science.gov (United States)

    Greenwald, M.; Bader, A.; Baek, S.; Bakhtiari, M.; Barnard, H.; Beck, W.; Bergerson, W.; Bespamyatnov, I.; Bonoli, P.; Brower, D.; Brunner, D.; Burke, W.; Candy, J.; Churchill, M.; Cziegler, I.; Diallo, A.; Dominguez, A.; Duval, B.; Edlund, E.; Ennever, P.; Ernst, D.; Faust, I.; Fiore, C.; Fredian, T.; Garcia, O.; Gao, C.; Goetz, J.; Golfinopoulos, T.; Granetz, R.; Grulke, O.; Hartwig, Z.; Horne, S.; Howard, N.; Hubbard, A.; Hughes, J.; Hutchinson, I.; Irby, J.; Izzo, V.; Kessel, C.; LaBombard, B.; Lau, C.; Li, C.; Lin, Y.; Lipschultz, B.; Loarte, A.; Marmar, E.; Mazurenko, A.; McCracken, G.; McDermott, R.; Meneghini, O.; Mikkelsen, D.; Mossessian, D.; Mumgaard, R.; Myra, J.; Nelson-Melby, E.; Ochoukov, R.; Olynyk, G.; Parker, R.; Pitcher, S.; Podpaly, Y.; Porkolab, M.; Reinke, M.; Rice, J.; Rowan, W.; Schmidt, A.; Scott, S.; Shiraiwa, S.; Sierchio, J.; Smick, N.; Snipes, J. A.; Snyder, P.; Sorbom, B.; Stillerman, J.; Sung, C.; Takase, Y.; Tang, V.; Terry, J.; Terry, D.; Theiler, C.; Tronchin-James, A.; Tsujii, N.; Vieira, R.; Walk, J.; Wallace, G.; White, A.; Whyte, D.; Wilson, J.; Wolfe, S.; Wright, G.; Wright, J.; Wukitch, S.; Zweben, S.

    2014-11-01

    The object of this review is to summarize the achievements of research on the Alcator C-Mod tokamak [Hutchinson et al., Phys. Plasmas 1, 1511 (1994) and Marmar, Fusion Sci. Technol. 51, 261 (2007)] and to place that research in the context of the quest for practical fusion energy. C-Mod is a compact, high-field tokamak, whose unique design and operating parameters have produced a wealth of new and important results since it began operation in 1993, contributing data that extends tests of critical physical models into new parameter ranges and into new regimes. Using only high-power radio frequency (RF) waves for heating and current drive with innovative launching structures, C-Mod operates routinely at reactor level power densities and achieves plasma pressures higher than any other toroidal confinement device. C-Mod spearheaded the development of the vertical-target divertor and has always operated with high-Z metal plasma facing components—approaches subsequently adopted for ITER. C-Mod has made ground-breaking discoveries in divertor physics and plasma-material interactions at reactor-like power and particle fluxes and elucidated the critical role of cross-field transport in divertor operation, edge flows and the tokamak density limit. C-Mod developed the I-mode and the Enhanced Dα H-mode regimes, which have high performance without large edge localized modes and with pedestal transport self-regulated by short-wavelength electromagnetic waves. C-Mod has carried out pioneering studies of intrinsic rotation and demonstrated that self-generated flow shear can be strong enough in some cases to significantly modify transport. C-Mod made the first quantitative link between the pedestal temperature and the H-mode's performance, showing that the observed self-similar temperature profiles were consistent with critical-gradient-length theories and followed up with quantitative tests of nonlinear gyrokinetic models. RF research highlights include direct experimental

  20. Disruption Warning Database Development and Exploratory Machine Learning Studies on Alcator C-Mod

    Science.gov (United States)

    Montes, Kevin; Rea, Cristina; Granetz, Robert

    2017-10-01

    A database of about 1800 shots from the 2015 campaign on the Alcator C-Mod tokamak is assembled, including disruptive and non-disruptive discharges. The database consists of 40 relevant plasma parameters with data taken from 160k time slices. In order to investigate the possibility of developing a robust disruption prediction algorithm that is tokamak-independent, we focused machine learning studies on a subset of dimensionless parameters such as βp, n /nG , etc. The Random Forests machine learning algorithm provides insight on the available data set by ranking the relative importance of the input features. Its application on the C-Mod database, however, reveals that virtually no one parameter has more importance than any other, and that its classification algorithm has a low rate of successfully predicted samples, as well as poor false positive and false negative rates. Comparing the analysis of this algorithm on the C-Mod database with its application to a similar database on DIII-D, we conclude that disruption prediction may not be feasible on C-Mod. This conclusion is supported by empirical observations that most C-Mod disruptions are caused by radiative collapse due to molybdenum from the first wall, which happens on just a 1-2ms timescale. Supported by the US Dept. of Energy under DE-FC02-99ER54512 and DE-FC02-04ER54698.

  1. PReMod: a database of genome-wide mammalian cis-regulatory module predictions.

    Science.gov (United States)

    Ferretti, Vincent; Poitras, Christian; Bergeron, Dominique; Coulombe, Benoit; Robert, François; Blanchette, Mathieu

    2007-01-01

    We describe PReMod, a new database of genome-wide cis-regulatory module (CRM) predictions for both the human and the mouse genomes. The prediction algorithm, described previously in Blanchette et al. (2006) Genome Res., 16, 656-668, exploits the fact that many known CRMs are made of clusters of phylogenetically conserved and repeated transcription factors (TF) binding sites. Contrary to other existing databases, PReMod is not restricted to modules located proximal to genes, but in fact mostly contains distal predicted CRMs (pCRMs). Through its web interface, PReMod allows users to (i) identify pCRMs around a gene of interest; (ii) identify pCRMs that have binding sites for a given TF (or a set of TFs) or (iii) download the entire dataset for local analyses. Queries can also be refined by filtering for specific chromosomal regions, for specific regions relative to genes or for the presence of CpG islands. The output includes information about the binding sites predicted within the selected pCRMs, and a graphical display of their distribution within the pCRMs. It also provides a visual depiction of the chromosomal context of the selected pCRMs in terms of neighboring pCRMs and genes, all of which are linked to the UCSC Genome Browser and the NCBI. PReMod: http://genomequebec.mcgill.ca/PReMod.

  2. Assessment of RELAP/MOD2 using large break loss-of-coolant experimental data

    International Nuclear Information System (INIS)

    Kao, L.; Liao, L.Y.; Liang, K.S.; Wang, S.F.; Chen, Y.B.

    1989-01-01

    In this paper assessment of RELAP5/MOD2 using LOFT L2-5 and Semiscale S-06-3 tests are performed to provide information of the code capability and its limitation in analyzing large break LOCA of a nuclear power plant. Experiments L2-5 and S-06-3 are conducted to simulate a hypothetical LOCA which results from a 200% double-ended offset shear break in the cold-leg of a typical pressurized water reactor by utilizing scaling facilities of the LOFT and Semiscale Mod-1 systems, respectively. The RELAP5/MOD2 calculations for both tests begin with break initiation and subsequent blowdown, continue through lower plenum refill, core reflood, and terminate with corewide quench. Major phenomena of both large break loss-of-coolant tests are well predicted by RELAP5/MOD2. The results indicate that the break flow and system pressure are reasonably calculated. The cladding temperature response during blowdown period, which is the major importance to a large break LOCA, calculated by RELAP5/MOD2 shows good agreement with the test data

  3. RELAP5/MOD2 calculation of OECD LOFT test LP-FW-01

    International Nuclear Information System (INIS)

    Croxfod, M.G.; Harwood, C.; Hall, P.C.

    1992-04-01

    RELAP5/MOD2 is being used by GDCD for calculation of certain small break loss-of-coolant accidents and pressurized transients in the Sizewell ''B'' PWR. To test the ability of RELAP5/MOD2 to model the primary feed-and-bleed recovery procedure following a complete loss- of-feedwater event, post test calculations have been carried out of OECD LOFT test LP-FW-01. This report describes the comparison between the code calculations and the test data. It is found that although the standard version of RELAP5/MOD2 gives a reasonable prediction of the experimental transient, the long term pressure history is better calculated with a modified code version containing a revised horizontal stratification entrainment model. The latter allows an improved calculation of entrainment of liquid from the hot leg into the surge line. RELAP5/MOD2 is found to give a more accurate simulation of the experimental transient than was achieved in previous UK studies using RETRAN-02/MOD2

  4. Culture and Creativity: World of Warcraft Modding in China and the US

    Science.gov (United States)

    Kow, Yong Ming; Nardi, Bonnie

    Modding - end-user modification of commercial hardware and software - can be traced back at least to 1961 when Spacewar! was developed by a group of MIT students on a DEC PDP-1. Spacewar! evolved into arcade games including Space Wars produced in 1977 by Cinematronics (Sotamaa 2003). In 1992, players altering Wolfenstein 3-D (1992), a first person shooter game made by id Software, overwrote the graphics and sounds by editing the game files. Learning from this experience, id Software released Doom in 1993 with isolated media files and open source code for players to develop custom maps, images, sounds, and other utilities. Players were able to pass on their modifications to others. By 1996, with the release of Quake, end-user modifications had come to be known as "mods," and modding was an accepted part of the gaming community (Kucklich 2005; Postigo 2008a, b). Since late-2005, we have been studying World of Warcraft (WoW) in which the use of mods is an important aspect of player practice (Nardi and Harris 2006; Nardi et al. 2007). Technically minded players with an interest in extending the game write mods and make them available to players for free download on distribution sites. Most modders work for free, but the distribution sites are commercial enterprises with advertising.

  5. The molybdate-binding protein (ModA) of the plant pathogen Xanthomonas axonopodis pv. citri.

    Science.gov (United States)

    Balan, Andrea; Santacruz, Carolina P; Moutran, Alexandre; Ferreira, Rita C C; Medrano, Francisco J; Pérez, Carlos A; Ramos, Carlos H I; Ferreira, Luís C S

    2006-12-01

    The modABC operon of phytopathogen Xanthomonas axonopodis pv. citri (X. citri) encodes a putative ABC transporter involved in the uptake of the molybdate and tungstate anions. Sequence analyses showed high similarity values of ModA orthologs found in X. campestris pv. campestris (X. campestris) and Escherichia coli. The X. citri modA gene was cloned in pET28a and the recombinant protein, expressed in the E. coli BL21 (DE3) strain, purified by immobilized metal affinity chromatography. The purified protein remained soluble and specifically bound molybdate and tungstate with K(d) 0.29+/-0.12 microM and 0.58+/-0.14 microM, respectively. Additionally binding of molybdate drastically enhanced the thermal stability of the recombinant ModA as compared to the apoprotein. This is the first characterization of a ModA ortholog expressed by a phytopathogen and represents an important tool for functional, biochemical and structural analyses of molybdate transport in Xanthomonas species.

  6. Endogenous Locus Reporter Assays.

    Science.gov (United States)

    Liu, Yaping; Hermes, Jeffrey; Li, Jing; Tudor, Matthew

    2018-01-01

    Reporter gene assays are widely used in high-throughput screening (HTS) to identify compounds that modulate gene expression. Traditionally a reporter gene assay is built by cloning an endogenous promoter sequence or synthetic response elements in the regulatory region of a reporter gene to monitor transcriptional activity of a specific biological process (exogenous reporter assay). In contrast, an endogenous locus reporter has a reporter gene inserted in the endogenous gene locus that allows the reporter gene to be expressed under the control of the same regulatory elements as the endogenous gene, thus more accurately reflecting the changes seen in the regulation of the actual gene. In this chapter, we introduce some of the considerations behind building a reporter gene assay for high-throughput compound screening and describe the methods we have utilized to establish 1536-well format endogenous locus reporter and exogenous reporter assays for the screening of compounds that modulate Myc pathway activity.

  7. Experiment data report for semiscale Mod-1 test S-06-4 (LOFT counterpart test)

    International Nuclear Information System (INIS)

    Gillins, R.L.; Sackett, K.E.; Coppin, C.E.

    1977-12-01

    Recorded test data are presented for Test S-06-4 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-4 was conducted from initial conditions of 15,653 kPa and 564 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 100 percent of the maximum peak power density

  8. Experiment data report for semiscale Mod-1 test S-06-1 (LOFT counterpart test)

    International Nuclear Information System (INIS)

    Collins, B.L.; Patton, M.L. Jr.; Sackett, K.E.

    1977-07-01

    Recorded test data are presented for Test S-06-1 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying an hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-1 was conducted from initial conditions of 15 568 kPa and 564 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 30% of the maximum peak power density

  9. Experiment data report for Semiscale Mod-1 Test S-05-1 (alternate ECC injection test)

    International Nuclear Information System (INIS)

    Feldman, E.M.; Patton, M.L. Jr.; Sackett, K.E.

    1977-02-01

    Recorded test data are presented for Test S-05-1 of the Semiscale Mod-1 alternate ECC injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-1 was conducted from initial conditions of 2263 psia and 544 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the vessel lower plenum to simulate emergency core coolant injection in a PWR, with the flow rate based on system volume scaling

  10. Experiment data report for Semiscale Mod-1 Test S-05-4 (alternate ECC injection test)

    International Nuclear Information System (INIS)

    Collins, B.L.; Feldman, E.M.

    1977-03-01

    Recorded test data are presented for Test S-05-4 of the Semiscale Mod-1 alternate emergency core coolant injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-4 was conducted from initial conditions of 2266 psia and 543 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the cold leg of each loop and into the vessel upper plenum to simulate emergency core coolant injection in a PWR. The upper plenum coolant injection was scaled according to the heat stored in the metal mass of the upper plenum

  11. Real-time sensing and gas jet mitigation of VDEs on Alcator C-Mod

    Science.gov (United States)

    Granetz, R. S.; Wolfe, S. M.; Izzo, V. A.; Reinke, M. L.; Terry, J. L.; Hughes, J. W.; Zhurovich, K.; Whyte, D. G.; Bakhtiari, M.; Wurden, G.

    2006-10-01

    Experiments have been carried out in Alcator C-Mod to test the effectiveness of gas jet disruption mitigation of VDEs with real-time detection and triggering by the C-Mod digital plasma control system (DPCS). The DPCS continuously computes the error in the plasma vertical position from the magnetics diagnostics. When this error exceeds an adjustable preset value, the DPCS triggers the gas jet valve (with a negligible latency time). The high-pressure gas (argon) only takes a few milliseconds to enter the vacuum chamber and begin affecting the plasma, but this is comparable to the VDE timescale on C-Mod. Nevertheless, gas jet injection reduced the halo current, increased the radiated power fraction, and reduced the heating of the divertor compared to unmitigated disruptions, but not quite as well as in earlier mitigation experiments with vertically stable plasmas. Presumably a faster overall response time would be beneficial, and several ways to achieve this will also be discussed.

  12. Radon transport modelling: User's guide to RnMod3d

    DEFF Research Database (Denmark)

    Andersen, Claus Erik

    2000-01-01

    RnMod3d is a numerical computer model of soil-gas and radon transport in porous media. It can be used, for example, to study radon entry from soil into houses in response to indoor-outdoor pressure differences or changes in atmospheric pressure. It canalso be used for flux calculations of radon...... decay, diffusion and advection of radon can be solved. Moisture is included in the model, and partitioning ofradon between air, water and soil grains (adsorption) is taken into account. Most parameters can change in time and space, and transport parameters (diffusivity and permeability) may...... be anisotropic. This guide includes benchmark tests based on simpleproblems with known solutions. RnMod3d has also been part of an international model intercomparison exercise based on more complicated problems without known solutions. All tests show that RnMod3d gives results of good quality....

  13. Preliminary assessment of PWR Steam Generator modelling in RELAP5/MOD3

    International Nuclear Information System (INIS)

    Preece, R.J.; Putney, J.M.

    1993-07-01

    A preliminary assessment of Steam Generator (SG) modelling in the PWR thermal-hydraulic code RELAP5/MOD3 is presented. The study is based on calculations against a series of steady-state commissioning tests carried out on the Wolf Creek PWR over a range of load conditions. Data from the tests are used to assess the modelling of primary to secondary side heat transfer and, in particular, to examine the effect of reverting to the standard form of the Chen heat transfer correlation in place of the modified form applied in RELAP5/MOD2. Comparisons between the two versions of the code are also used to show how the new interphase drag model in RELAP5/MOD3 affects the calculation of SG liquid inventory and the void fraction profile in the riser

  14. Experiment data report for semiscale Mod-1 Test S-06-2 (LOFT counterpart test)

    International Nuclear Information System (INIS)

    Patton, M.L. Jr.; Collins, B.L.; Sackett, K.E.

    1977-08-01

    Recorded test data are presented for Test S-06-2 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying an hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-2 was conducted from initial conditions of 15 513 kPa and 563 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 50% of the maximum peak power density

  15. Experiment data report for Semiscale Mod-1 Test S-05-5 (alternate ECC injection test)

    International Nuclear Information System (INIS)

    Collins, B.L.; Patton, M.L. Jr.; Sackett, K.E.

    1977-04-01

    Recorded test data are presented for Test S-05-5 of the Semiscale Mod-1 alternate ECC injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-5 was conducted from initial conditions of 2263 psia and 537 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. The upper plenum was vented through a reflood bypass line interconnecting the hot and cold legs of the broken loop

  16. Experiment data report for Semiscale Mod-1 Test S-05-3 (alternate ECC injection test)

    International Nuclear Information System (INIS)

    Feldman, E.M.; Patton, M.L. Jr.; Sackett, K.E.

    1977-03-01

    Recorded test data are presented for Test S-05-3 of the Semiscale Mod-1 alternate ECC injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-3 was conducted from initial conditions of 2263 psia and 545 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the cold leg sides of the intact and broken loops and into the vessel upper plenum to simulate emergency core coolant injection in a PWR. For Test S-05-3, specifically the effects of upper plenum coolant injection on core thermal and system response were being investigated

  17. Antimicrobial susceptibility patterns of Brazilian Haemophilus parasuis field isolates

    Directory of Open Access Journals (Sweden)

    Michela Miani

    Full Text Available ABSTRACT: Haemophilus parasuis is the etiological agent of Glässer’s disease (GD, an ubiquitous infection of swine characterized by systemic fibrinous polyserositis, polyarthritis and meningitis. Intensive use of antimicrobial agents in swine husbandries during the last years triggered the development of antibiotic resistances in bacterial pathogens. Thus, regular susceptibility testing is crucial to ensure efficacy of different antimicrobial agents to this porcine pathogen. In this study, 50 clinical isolates from South Brazilian pig herds were characterized and analyzed for their susceptibility to commonly used antibiotic. The identification and typing of clinical isolates was carried out by a modified indirect hemagglutination assay combined with a multiplex PCR. The susceptibility of each isolate was analyzed by broth microdilution method against a panel of 21 antimicrobial compounds. We found that field isolates are highly resistance to gentamycin, bacitracin, lincomycin and tiamulin, but sensitive to ampicillin, clindamycin, neomycin, penicillin, danofloxacin and enrofloxacin. Furthermore, an individual susceptibility analysis indicated that enrofloxacin is effective to treat clinical isolates with the exception of those classified as serovar 1. The results presented here firstly demonstrate the susceptibility of Brazilian clinical isolates of H. parasuis to antimicrobials widely used by swine veterinary practitioners and strengthen the need to perform susceptibility test prior to antibiotic therapy during GD outbreaks. In addition, because only six antimicrobial drugs (28.6% were found effective against field isolates, a continuous surveillance of the susceptibility profile should be of major concern to the swine industry.

  18. Solid phase assays

    International Nuclear Information System (INIS)

    Reese, M.G.; Johnson, L.R.; Ransom, D.K.

    1980-01-01

    In a solid phase assay for quantitative determination of biological and other analytes, a sample such as serum is contacted with a receptor for the analyte being assayed, the receptor being supported on a solid support. No tracer for the analyte is added to the sample before contacting with the receptor; instead the tracer is contacted with the receptor after unbound analyte has been removed from the receptor. The assay can be otherwise performed in a conventional manner but can give greater sensitivity. (author)

  19. Mise en place d'une base de données pour une modélisation ...

    African Journals Online (AJOL)

    Mise en place d'une base de données pour une modélisation hydrologique distribuée du bassin versant du Bandama (Côte d'Ivoire) : apport d'un modèle numérique d'altitude, de la télédétection et du SIG Physitel.

  20. Mod-5A wind turbine generator program design report. Volume 3: Final design and system description, book 1

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. Volume 3, book 1 describes the performance and characteristics of the MOD-5A wind turbine generator in its final configuration. Each subsystem - the rotor, drivetrain, nacelle, tower and foundation is described in detail.

  1. RELAP5/MOD2 Overview and Developmental. Assessment Results from TMl-1 Plant Transient Analysis

    International Nuclear Information System (INIS)

    Lin, J. C.; Tsai, C. C.; Ransom, V. H.; Johnsen, G. W.

    2013-01-01

    RELAP5/MOD2 is a new version of the RELAP5 thermal-hydraulic computer code containing improved modeling features that provide a generic capability for pressurized water reactor transient simulation. The objective of this paper is to provide code users with an overview of the code and to report developmental assessment results obtained from a Three Mile Island Unit One plant transient analysis. The assessment shows that the injection of highly sub-cooled water into a high-pressure primary coolant system does not cause unphysical results or pose a problem for RELAP5/MOD2. (author)

  2. Code Development and Analysis Program: developmental checkout of the BEACON/MOD2A code

    International Nuclear Information System (INIS)

    Ramsthaler, J.A.; Lime, J.F.; Sahota, M.S.

    1978-12-01

    A best-estimate transient containment code, BEACON, is being developed by EG and G Idaho, Inc. for the Nuclear Regulatory Commission's reactor safety research program. This is an advanced, two-dimensional fluid flow code designed to predict temperatures and pressures in a dry PWR containment during a hypothetical loss-of-coolant accident. The most recent version of the code, MOD2A, is presently in the final stages of production prior to being released to the National Energy Software Center. As part of the final code checkout, seven sample problems were selected to be run with BEACON/MOD2A

  3. Assessment of RELAP5/MOD2 against a natural circulation experiment in Nuclear Power Plant Borssele

    International Nuclear Information System (INIS)

    Winters, L.

    1993-07-01

    As part of the ICAP (International Code Assessment and Applications Program) agreement between ECN (Netherlands Energy Research Foundation) and USNRC, ECN has performed a number of assessment calculations for the thermohydraulic system analysis code RELAP5/MOD2/36.05. This document describes the assessment of this computer program versus a natural circulation experiment as conducted at the Borssele Nuclear Power Plant. The results of this comparison show that the code RELAP5/MOD2 predicts well the natural circulation behaviour of Nuclear Power Plant Borssele

  4. Autres modèles de prestation de services publics dans les ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les écrits sur la prestation de services publics à l'aide de modèles différents ont porté jusqu'à maintenant sur des endroits très précis. Ils ont par ailleurs été circonscrits à des secteurs donnés et ont manqué d'uniformité sur le plan méthodologique. Ce projet vise à analyser les modèles de prestation de services de santé, ...

  5. Assessment and improvement of condensation model in RELAP5/MOD3

    Energy Technology Data Exchange (ETDEWEB)

    Rho, Hui Cheon; Choi, Kee Yong; Park, Hyeon Sik; Kim, Sang Jae [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Lee, Sang Il [Korea Power Engineering Co., Inc., Seoul (Korea, Republic of)

    1997-07-15

    The objective of this research is to remove the uncertainty of the condensation model through the assessment and improvement of the various heat transfer correlations used in the RELAP5/MOD3 code. The condensation model of the standard RELAP5/MOD3 code is systematically arranged and analyzed. A condensation heat transfer database is constructed from the previous experimental data on various condensation phenomena. Based on the constructed database, the condensation models in the code are assessed and improved. An experiment on the reflux condensation in a tube of steam generator in the presence of noncondensable gases is planned to acquire the experimental data.

  6. Modèles d'affaires ouverts : nouveaux mécanismes de revenus pour ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Ce projet de recherche vise à examiner les principaux modèles d'affaires qui émergent dans une société réseautée, les répercussions qu'ont ces modèles sur les droits des consommateurs et des créateurs et le rôle qu'ils peuvent jouer pour favoriser une plus grande inclusion et la diversité culturelle. Le projet se penchera ...

  7. Use of moving heat conductor mesh to perform reflood calculations with RELAP4/MOD6

    International Nuclear Information System (INIS)

    Fischer, S.R.; Ellis, L.V.; Chen, Y.S.

    1979-01-01

    RELAP4 is a computer code which can be used for the transient thermal hydraulic analysis of light water reactors and related systems. RELAP4/MOD6 includes many new analytical models which were developed primarily for the analysis of the reflood phase of a PWR loss-of-coolant accident (LOCA) transient. The key feature forming the basis for the MOD6 reflood calculation is a unique moving finite differenced heat conductor. The development and application of the moving heat conductor mesh for use in reflood analysis are described

  8. Analysis of the reflood experiment by RELAP5/MOD2 code

    International Nuclear Information System (INIS)

    Prosek, A.; Stritar, A.

    1990-01-01

    The analysis of the reflood experiment on the test rig Achilles has been performed. The analysis has been done by the RELAP5/MOD2 code after the results of the experiment had been released. The experiment has been analyze in several other laboratories around the world. Our results are comparable to other analyses and are in the range of RELAP5/MOD2 capabilities. Two analyses have been done: the core only and the complete system. Computed clad temperatures in the first case are higher than measured, in the second case they are somewhat lower. (author)

  9. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 4

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator are documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This volume contains 5 books of which this is the fourth, providing drawings 47A380128 through 47A387125. In addition to the parts listing and where-used list, the logic design of the controller software and the code listing of the controller software are provided. Also given are the aerodynamic profile coordinates.

  10. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 2

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the second book of volume four. Some of the items it contains are specs for the emergency shutdown panel, specs for the simulator software, simulator hardware specs, site operator terminal requirements, control data system requirements, software project management plan, elastomeric teeter bearing requirement specs, specs for the controls electronic cabinet, and specs for bolt pretensioning.

  11. Mod-5A Wind Turbine Generator Program Design Report. Volume 4: Drawings and Specifications, Book 1

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. Volume 4 contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the first of five books of volume four. It contains structural design criteria, generator step-up transformer specs, specs for design, fabrication and testing of the system, specs for the ground control enclosure, systems specs, slip ring specs, and control system specs.

  12. Chromate Binding and Removal by the Molybdate-Binding Protein ModA.

    Science.gov (United States)

    Karpus, Jason; Bosscher, Michael; Ajiboye, Ifedayo; Zhang, Liang; He, Chuan

    2017-04-04

    Effective and cheap methods and techniques for the safe removal of hexavalent chromate from the environment are in increasingly high demand. High concentrations of hexavalent chromate have been shown to have numerous harmful effects on human biology. We show that the E. coli molybdate-binding protein ModA is a genetically encoded tool capable of removing chromate from aqueous solutions. Although previously reported to not bind chromate, we show that ModA binds chromate tightly and is capable of removing chromate to levels well below current US federal standards. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

    Energy Technology Data Exchange (ETDEWEB)

    Yang, S.Y. [MagQu Co. Ltd., Sindian City, Taipei County 231, Taiwan (China); Institute of Electro-optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (China); Lan, C.B.; Chen, C.H. [Institute of Electro-optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (China); Horng, H.E. [Institute of Electro-optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (China)], E-mail: phyfv001@scc.ntnu.edu.tw; Hong, Chin-Yih [Department of Mechanical Engineering, Nan-Kai University of Technology, Nantau County, Taiwan (China)], E-mail: cyhong@nkut.edu.tw; Yang, H.C. [Department of Physics, National Taiwan University, Taipei 106, Taiwan (China)], E-mail: hcyang@phys.ntu.edu.tw; Lai, Y.K. [College of Life Sciences, National Tsing Hua University, Hsinchu City 300, Taiwan (China); Department of Bioresources, Da-Yeh University, Changhua 515, Taiwan (China); Lin, Y.H.; Teng, K.S. [Apex Biotechnology Co. Ltd., Hsinchu City 300, Taiwan (China)

    2009-10-15

    Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

  14. Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

    International Nuclear Information System (INIS)

    Yang, S.Y.; Lan, C.B.; Chen, C.H.; Horng, H.E.; Hong, Chin-Yih; Yang, H.C.; Lai, Y.K.; Lin, Y.H.; Teng, K.S.

    2009-01-01

    Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

  15. Modélisation de l'évaporation en milieu poreux: développement de modèles fondamentaux et appliqués

    OpenAIRE

    Debaste, Frédéric

    2008-01-01

    L'étude des phénomènes fondamentaux detransport et de thermodynamique apparaissant lors de l'évaporationen milieu poreux permet l'investigation d'applications pratiquesvariées. Dans ce travail, nous développons des modèles fondamentauxd'évaporation en milieu poreux que nous appliquons ensuite auséchage en lit fluidisé de deux matériaux granulaires poreux :lePVC et la levure.Les modèles mis au point sont réalisés suivant une approchemultiéchelle. Nous nous intéressons tout d'abord aux phénomèn...

  16. Factor IX assay

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003679.htm Factor IX assay To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  17. Factor VIII assay

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003678.htm Factor VIII assay To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  18. Factor II assay

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003674.htm Factor II assay To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  19. Factor VII assay

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/003676.htm Factor VII assay To use the sharing features on ... M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health ...

  20. Microbead agglutination based assays

    KAUST Repository

    Kodzius, Rimantas; Castro, David; Foulds, Ian G.; Parameswaran, Ash M.; Sumanpreet, K. Chhina

    2013-01-01

    We report a simple and rapid room temperature assay for point-of-care (POC) testing that is based on specific agglutination. Agglutination tests are based on aggregation of microbeads in the presence of a specific analyte thus enabling

  1. Estimation des paramètres de modèles pour la digestion anaérobie

    OpenAIRE

    Martinez , Ricardo

    2003-01-01

    La finalité de ce travail a été d'estimer de la meilleure manière possible des paramètres de différents modèles sur la respiration anaérobie. Dans un premier temps nous présentons les bases qu'on utilise pour construire les modèles du procédé biochimique. Puis nous faisons une analyse qualitative des modèles les plus connus sur le sujet. Dans un deuxième temps nous avons suggéré différents modèles, afin de mieux estimer les paramètres du modèle initial. Nous avons mis au point un programme d'...

  2. 64 Application d'un modèle conceptuel et d'un modèle de réseaux ...

    African Journals Online (AJOL)

    PR BOKO

    Application of a conceptual model and a model of artificial neural networks for the ... évaluer l'impact hydrologique d'un aménagement d'un bassin ou pour ... une catégorie de modèles pluie–débit basée sur l'intelligence artificielle [4]. ..... et D.P. SOLOMATINE, « River flow forecasting using Artificial Neuronal Networks”.

  3. An evaluation of TRAC-PF1/MOD1 computer code performance during posttest simulations of Semiscale MOD-2C feedwater line break transients

    International Nuclear Information System (INIS)

    Hall, D.G.; Watkins, J.C.

    1987-01-01

    This report documents an evaluation of the TRAC-PF1/MOD1 reactor safety analysis computer code during computer simulations of feedwater line break transients. The experimental data base for the evaluation included the results of three bottom feedwater line break tests performed in the Semiscale Mod-2C test facility. The tests modeled 14.3% (S-FS-7), 50% (S-FS-11), and 100% (S-FS-6B) breaks. The test facility and the TRAC-PF1/MOD1 model used in the calculations are described. Evaluations of the accuracy of the calculations are presented in the form of comparisons of measured and calculated histories of selected parameters associated with the primary and secondary systems. In addition to evaluating the accuracy of the code calculations, the computational performance of the code during the simulations was assessed. A conclusion was reached that the code is capable of making feedwater line break transient calculations efficiently, but there is room for significant improvements in the simulations that were performed. Recommendations are made for follow-on investigations to determine how to improve future feedwater line break calculations and for code improvements to make the code easier to use

  4. Origin of the diversity in DNA recognition domains in phasevarion associated modA genes of pathogenic Neisseria and Haemophilus influenzae.

    Science.gov (United States)

    Gawthorne, Jayde A; Beatson, Scott A; Srikhanta, Yogitha N; Fox, Kate L; Jennings, Michael P

    2012-01-01

    Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic bacteria. In some it has been demonstrated that the random switching of the mod (DNA methyltransferase) gene mediates the coordinated expression of multiple genes and constitutes a phasevarion (phase variable regulon). ModA of Neisseria and Haemophilus influenzae contain a highly variable, DNA recognition domain (DRD) that defines the target sequence that is modified by methylation and is used to define modA alleles. 18 distinct modA alleles have been identified in H. influenzae and the pathogenic Neisseria. To determine the origin of DRD variability, the 18 modA DRDs were used to search the available databases for similar sequences. Significant matches were identified between several modA alleles and mod gene from distinct bacterial species, indicating one source of the DRD variability was via horizontal gene transfer. Comparison of DRD sequences revealed significant mosaicism, indicating exchange between the Neisseria and H. influenzae modA alleles. Regions of high inter- and intra-allele similarity indicate that some modA alleles had undergone recombination more frequently than others, generating further diversity. Furthermore, the DRD from some modA alleles, such as modA12, have been transferred en bloc to replace the DRD from different modA alleles.

  5. Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni.

    Directory of Open Access Journals (Sweden)

    Sandra D Melman

    2009-08-01

    Full Text Available The near exclusive use of praziquantel (PZQ for treatment of human schistosomiasis has raised concerns about the possible emergence of drug-resistant schistosomes.We measured susceptibility to PZQ of isolates of Schistosoma mansoni obtained from patients from Kisumu, Kenya continuously exposed to infection as a consequence of their occupations as car washers or sand harvesters. We used a an in vitro assay with miracidia, b an in vivo assay targeting adult worms in mice and c an in vitro assay targeting adult schistosomes perfused from mice. In the miracidia assay, in which miracidia from human patients were exposed to PZQ in vitro, reduced susceptibility was associated with previous treatment of the patient with PZQ. One isolate ("KCW" that was less susceptible to PZQ and had been derived from a patient who had never fully cured despite multiple treatments was studied further. In an in vivo assay of adult worms, the KCW isolate was significantly less susceptible to PZQ than two other isolates from natural infections in Kenya and two lab-reared strains of S. mansoni. The in vitro adult assay, based on measuring length changes of adults following exposure to and recovery from PZQ, confirmed that the KCW isolate was less susceptible to PZQ than the other isolates tested. A sub-isolate of KCW maintained separately and tested after three years was susceptible to PZQ, indicative that the trait of reduced sensitivity could be lost if selection was not maintained.Isolates of S. mansoni from some patients in Kisumu have lower susceptibility to PZQ, including one from a patient who was never fully cured after repeated rounds of treatment administered over several years. As use of PZQ continues, continued selection for worms with diminished susceptibility is possible, and the probability of emergence of resistance will increase as large reservoirs of untreated worms diminish. The potential for rapid emergence of resistance should be an important

  6. Detection of induced male germline mutation: Correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays

    Energy Technology Data Exchange (ETDEWEB)

    Singer, Timothy M. [Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont., K1A 0K9 (Canada); Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ont., K1S 5B6 (Canada); Lambert, Iain B. [Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ont., K1S 5B6 (Canada); Williams, Andrew [Biostatistics and Epidemiology Division, Safe Environments Programme, 6604B, Health Canada, Ottawa, Ont., K1A 0K9 (Canada); Douglas, George R. [Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont., K1A 0K9 (Canada); Yauk, Carole L. [Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont., K1A 0K9 (Canada)]. E-mail: carole_yauk@hc-sc.gc.ca

    2006-06-25

    Several rodent assays are capable of monitoring germline mutation. These include traditional assays, such as the dominant lethal (DL) assay, the morphological specific locus (SL) test and the heritable translocation (HT) assay, and two assays that have been developed more recently-the expanded simple tandem repeat (ESTR) and transgenic rodent (TGR) mutation assays. In this paper, we have compiled the limited amount of experimental data that are currently available to make conclusions regarding the comparative ability of the more recently developed assays to detect germline mutations induced by chemical and radiological agents. The data suggest that ESTR and TGR assays are generally comparable with SL in detecting germline mutagenicity induced by alkylating agents and radiation, though TGR offered less sensitivity than ESTR in some cases. The DL and HT assays detect clastogenic events and are most susceptible to mutations arising in post-spermatogonial cells, and they may not provide the best comparisons with TGR and ESTR instability. The measurement of induced ESTR instability represents a relatively sensitive method of identifying agents causing germline mutation in rodents, and may also be useful for bio-monitoring exposed individuals in the human population. Any future use of the TGR and ESTR germline mutation assays in a regulatory testing context will entail more robust and extensive characterization of assay performance. This will require substantially more data, including experiments measuring multiple endpoints, a greatly expanded database of chemical agents and a focus on characterizing stage-specific activity of mutagens in these assays, preferably by sampling epididymal sperm exposed at defined pre-meiotic, meiotic and post-meiotic stages of development.

  7. Detection of induced male germline mutation: Correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays

    International Nuclear Information System (INIS)

    Singer, Timothy M.; Lambert, Iain B.; Williams, Andrew; Douglas, George R.; Yauk, Carole L.

    2006-01-01

    Several rodent assays are capable of monitoring germline mutation. These include traditional assays, such as the dominant lethal (DL) assay, the morphological specific locus (SL) test and the heritable translocation (HT) assay, and two assays that have been developed more recently-the expanded simple tandem repeat (ESTR) and transgenic rodent (TGR) mutation assays. In this paper, we have compiled the limited amount of experimental data that are currently available to make conclusions regarding the comparative ability of the more recently developed assays to detect germline mutations induced by chemical and radiological agents. The data suggest that ESTR and TGR assays are generally comparable with SL in detecting germline mutagenicity induced by alkylating agents and radiation, though TGR offered less sensitivity than ESTR in some cases. The DL and HT assays detect clastogenic events and are most susceptible to mutations arising in post-spermatogonial cells, and they may not provide the best comparisons with TGR and ESTR instability. The measurement of induced ESTR instability represents a relatively sensitive method of identifying agents causing germline mutation in rodents, and may also be useful for bio-monitoring exposed individuals in the human population. Any future use of the TGR and ESTR germline mutation assays in a regulatory testing context will entail more robust and extensive characterization of assay performance. This will require substantially more data, including experiments measuring multiple endpoints, a greatly expanded database of chemical agents and a focus on characterizing stage-specific activity of mutagens in these assays, preferably by sampling epididymal sperm exposed at defined pre-meiotic, meiotic and post-meiotic stages of development

  8. Local quantum thermal susceptibility

    Science.gov (United States)

    de Pasquale, Antonella; Rossini, Davide; Fazio, Rosario; Giovannetti, Vittorio

    2016-09-01

    Thermodynamics relies on the possibility to describe systems composed of a large number of constituents in terms of few macroscopic variables. Its foundations are rooted into the paradigm of statistical mechanics, where thermal properties originate from averaging procedures which smoothen out local details. While undoubtedly successful, elegant and formally correct, this approach carries over an operational problem, namely determining the precision at which such variables are inferred, when technical/practical limitations restrict our capabilities to local probing. Here we introduce the local quantum thermal susceptibility, a quantifier for the best achievable accuracy for temperature estimation via local measurements. Our method relies on basic concepts of quantum estimation theory, providing an operative strategy to address the local thermal response of arbitrary quantum systems at equilibrium. At low temperatures, it highlights the local distinguishability of the ground state from the excited sub-manifolds, thus providing a method to locate quantum phase transitions.

  9. Topological Susceptibility from Slabs

    CERN Document Server

    Bietenholz, Wolfgang; Gerber, Urs

    2015-01-01

    In quantum field theories with topological sectors, a non-perturbative quantity of interest is the topological susceptibility chi_t. In principle it seems straightforward to measure chi_t by means of Monte Carlo simulations. However, for local update algorithms and fine lattice spacings, this tends to be difficult, since the Monte Carlo history rarely changes the topological sector. Here we test a method to measure chi_t even if data from only one sector are available. It is based on the topological charges in sub-volumes, which we denote as slabs. Assuming a Gaussian distribution of these charges, this method enables the evaluation of chi_t, as we demonstrate with numerical results for non-linear sigma-models.

  10. Topological susceptibility from slabs

    Energy Technology Data Exchange (ETDEWEB)

    Bietenholz, Wolfgang [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, A.P. 70-543, Distrito Federal, C.P. 04510 (Mexico); Forcrand, Philippe de [Institute for Theoretical Physics, ETH Zürich,CH-8093 Zürich (Switzerland); CERN, Physics Department, TH Unit, CH-1211 Geneva 23 (Switzerland); Gerber, Urs [Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, A.P. 70-543, Distrito Federal, C.P. 04510 (Mexico); Instituto de Física y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo,Edificio C-3, Apdo. Postal 2-82, Morelia, Michoacán, C.P. 58040 (Mexico)

    2015-12-14

    In quantum field theories with topological sectors, a non-perturbative quantity of interest is the topological susceptibility χ{sub t}. In principle it seems straightforward to measure χ{sub t} by means of Monte Carlo simulations. However, for local update algorithms and fine lattice spacings, this tends to be difficult, since the Monte Carlo history rarely changes the topological sector. Here we test a method to measure χ{sub t} even if data from only one sector are available. It is based on the topological charges in sub-volumes, which we denote as slabs. Assuming a Gaussian distribution of these charges, this method enables the evaluation of χ{sub t}, as we demonstrate with numerical results for non-linear σ-models.

  11. Local quantum thermal susceptibility

    Science.gov (United States)

    De Pasquale, Antonella; Rossini, Davide; Fazio, Rosario; Giovannetti, Vittorio

    2016-01-01

    Thermodynamics relies on the possibility to describe systems composed of a large number of constituents in terms of few macroscopic variables. Its foundations are rooted into the paradigm of statistical mechanics, where thermal properties originate from averaging procedures which smoothen out local details. While undoubtedly successful, elegant and formally correct, this approach carries over an operational problem, namely determining the precision at which such variables are inferred, when technical/practical limitations restrict our capabilities to local probing. Here we introduce the local quantum thermal susceptibility, a quantifier for the best achievable accuracy for temperature estimation via local measurements. Our method relies on basic concepts of quantum estimation theory, providing an operative strategy to address the local thermal response of arbitrary quantum systems at equilibrium. At low temperatures, it highlights the local distinguishability of the ground state from the excited sub-manifolds, thus providing a method to locate quantum phase transitions. PMID:27681458

  12. Susceptibility to anchoring effects

    Directory of Open Access Journals (Sweden)

    Todd McElroy

    2007-02-01

    Full Text Available Previous research on anchoring has shown this heuristic to be a very robust psychological phenomenon ubiquitous across many domains of human judgment and decision-making. Despite the prevalence of anchoring effects, researchers have only recently begun to investigate the underlying factors responsible for how and in what ways a person is susceptible to them. This paper examines how one such factor, the Big-Five personality trait of openness-to-experience, influences the effect of previously presented anchors on participants' judgments. Our findings indicate that participants high in openness-to-experience were significantly more influenced by anchoring cues relative to participants low in this trait. These findings were consistent across two different types of anchoring tasks providing convergent evidence for our hypothesis.

  13. Modèles de gestion des ressources forestières du massif ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Expérimentation Participative et Adaptative de Modèles de Gestion des Ressources Forestières dans la Chaine Montagneuse de l'Atlas (Algérie, Maroc, Tunisie) : rapport final (17 mars 2009 au 18 septembre 2012). Download PDF. Reports. Unité de transformation de cire d'abeille (Commune de M'Sara). Download PDF ...

  14. Analysis of Semiscale Mod-1 integral test with asymmetrical break (Test S-29-1)

    International Nuclear Information System (INIS)

    Langerman, M.A.

    1977-03-01

    Selected experimental data obtained from Semiscale Mod-1 cold leg break Test S-29-1 and results obtained from analytical codes are analyzed. This test was the first integral blowdown reflood test conducted with the Mod-1 system and was a special test designed specifically to evaluate the sensitivity of the early Mod-1 core thermal response (0 to 5 sec after rupture) to the magnitude and direction of the core flow. To achieve this specific objective in Test S-29-1, the vessel side break area was reduced to approximately one-half the scaled break area associated with a 200 percent cold leg break test. The reduction in break area significantly reduced the core flow reversal that took place immediately after rupture and resulted in periods of positive core flow in the early portion of the test. The results obtained from this test are compared with results obtained from a 200 percent cold leg break test and the effect of core flow on early core thermal response is evaluated. Since Test S-29-1 was the first integral blowdown reflood test conducted with the Mod-1 system, data are also presented through the reflood stage of the test and the results are analyzed. The test data and the core thermal response calculated with the RELAP4 code are also compared

  15. Effect of reflection on Hα emissions in Alcator C-MOD

    International Nuclear Information System (INIS)

    Karney, C.F.; Stotler, D.P.; Skinner, C.H.; Terry, J.L.; Pappas, D.A.

    1999-01-01

    In order to explain anomalous intensity ratios which have been observed in Alcator C-MOD, the H α emissions in that experiment have been modeled with the DEGAS 2 code including the effects of wall reflection. By assuming that the first wall has different reflection coefficients for the two polarizations, we have qualitatively reproduced the observed anomaly. copyright 1999 American Institute of Physics

  16. Blob sizes and velocities in the Alcator C-Mod scrape-off layer

    DEFF Research Database (Denmark)

    Kube, R.; Garcia, O.E.; LaBombard, B.

    A new blob-tracking algorithm for the GPI diagnostic installed in the outboard-midplane of Alcator C-Mod is developed. I t tracks large-amplitude fluctuations propagating through the scrape-off layer and calculates blob sizes and velocities. We compare the results of this method to a blob velocity...

  17. RETRAN-3D MOD003 Peach Bottom Turbine Trip 2 Multidimensional Kinetics Analysis Models and Results

    International Nuclear Information System (INIS)

    Mori, Michitsugu; Ogura, Katsunori; Gose, Garry C.; Wu, J.-Y.

    2003-01-01

    An analysis of the Peach Bottom Unit 2 Turbine Trip Test 2 (PB2/TT2) has been performed using RETRAN-3D MOD003. The purpose of the analysis was to investigate the PB2/TT2 overpressurization transient using the RETRAN-3D multidimensional kinetics model

  18. Comparison of MAAP4.03 with RELAP/SCDAPSIM/MOD3.2

    Energy Technology Data Exchange (ETDEWEB)

    Kohriyama, T.; Ohtani, M. [Technical Support Project, Institute of Nuclear Technology, Institute of Nuclear Safety System, Incorporated, Mihama, Fukui (Japan); Ezzidi, A.; Morota, H. [Computer Software Development Co., Ltd., Tokyo (Japan)

    2000-11-01

    The MAAP4.03 code has been widely used for analyses of severe accident phenomena. It is, however, a system level code applying simpler models and could show phenomenological uncertainties. In order to support MAAP4.03 by a more detailed mechanistic code such as RELAP/SCDAPSIM/MOD3.2, code-to-code comparisons are performed. For a typical 4 loop PWR, analyses of two severe accident sequences were executed. Both codes predicted similar tendencies until the beginning of core melt. MAAP4.03 showed earlier slumping of molten core to a lower head of a reactor pressure vessel than RELAP/SCDAPSIM/MOD3.2. MAAP4.03 considers only axial flows of molten core and crusts suddenly breach by Creep Rupture. RELAP/SCDAPSIM/MOD3.2 treats axial and radial spreads by repeated cycles of melting, flowing and freezing. Bottom crusts can be supported by intact fuel rods. By these more realistic RELAP/SCDAPSIM/MOD3.2 models, MAAP4.03 could be supported maintaining conservatism. (author)

  19. MOD/R : A knowledge assisted approach towards top-down only CMOS VLSI design

    NARCIS (Netherlands)

    Spaanenburg, L.; Beunder, M.; Beune, F.A.; Gerez, Sabih H.; Holstein, B.; Luchtmeyer, R.C.C.; Smit, Jaap; van der Werf, A.; Willems, H.

    1985-01-01

    MOD/R models all views on the design space in relations. This is achieved by eliminating the package constraints, as are apparent in PCB oriented hardware description languages. Assisted by knowledge engineering it allows for a top-down, mostly hierarchical decomposition, virtually eliminating the

  20. MOD-1 Wind Turbine Generator Analysis and Design Report, Volume 2

    Science.gov (United States)

    1979-01-01

    The MOD-1 detail design is appended. The supporting analyses presented include a parametric system trade study, a verification of the computer codes used for rotor loads analysis, a metal blade study, and a definition of the design loads at each principal wind turbine generator interface for critical loading conditions. Shipping and assembly requirements, composite blade development, and electrical stability are also discussed.

  1. Mod-1 wind turbine generator analysis and design report, volume 1

    Science.gov (United States)

    1979-01-01

    The activities leading to the completion of detail design of the MOD-1 wind turbine generator are described. Emphasis is placed on the description of the design as it finally evolved. However, the steps through which the design progressed are also traced in order to understand the major design decisions.

  2. Conceptual design of the 6 MW Mod-5A wind turbine generator

    Science.gov (United States)

    Barton, R. S.; Lucas, W. C.

    1982-01-01

    The General Electric Company, Advanced Energy Programs Department, is designing under DOE/NASA sponsorship the MOD-5A wind turbine system which must generate electricity for 3.75 cent/KWH (1980) or less. During the Conceptual Design Phase, completed in March, 1981, the MOD-5A WTG system size and features were established as a result of tradeoff and optimization studies driven by minimizing the system cost of energy (COE). This led to a 400' rotor diameter size. The MOD-5A system which resulted is defined in this paper along with the operational and environmental factors that drive various portions of the design. Development of weight and cost estimating relationships (WCER's) and their use in optimizing the MOD-5A are discussed. The results of major tradeoff studies are also presented. Subsystem COE contributions for the 100th unit are shown along with the method of computation. Detailed descriptions of the major subsystems are given, in order that the results of the various trade and optimization studies can be more readily visualized.

  3. Assay method and compositions

    International Nuclear Information System (INIS)

    1977-01-01

    Methods are described for measuring catecholamine levels in human and animal body fluids and tissues using the catechol-O-methyl-transferase (COMT) radioassay. The assay involves incubating the biological sample with COMT and the tritiated methyl donor, S-adenosyl-L-methionine( 3 H)-methyl. The O-methylated ( 3 H) epinephrine and/or norepinephrine are extracted and oxidised to vanillin- 3 H which in turn is extracted and its radioactivity counted. When analysing dopamine levels the assay is extended by vanillin- 3 H and raising the pH of the aqueous periodate phase from which O-methylated ( 3 H) dopamine is extracted and counted. The assay may be modified depending on whether measurements of undifferentiated total endogenous catecholamine levels or differential analyses of the catecholamine levels are being performed. The sensitivity of the assay can be as low as 5 picograms for norepinephrine and epinephrine and 12 picograms for dopamine. The assemblance of the essential components of the assay into a kit for use in laboratories is also described. (U.K.)

  4. Rover waste assay system

    Energy Technology Data Exchange (ETDEWEB)

    Akers, D.W.; Stoots, C.M.; Kraft, N.C.; Marts, D.J. [Idaho National Engineering Lab., Idaho Falls, ID (United States)

    1997-11-01

    The Rover Waste Assay System (RWAS) is a nondestructive assay system designed for the rapid assay of highly-enriched {sup 235}U contaminated piping, tank sections, and debris from the Rover nuclear rocket fuel processing facility at the Idaho Chemical Processing Plant. A scanning system translates a NaI(Tl) detector/collimator system over the structural components where both relative and calibrated measurements for {sup 137}Cs are made. Uranium-235 concentrations are in operation and is sufficiently automated that most functions are performed by the computer system. These functions include system calibration, problem identification, collimator control, data analysis, and reporting. Calibration of the system was done through a combination of measurements on calibration standards and benchmarked modeling. A description of the system is presented along with the methods and uncertainties associated with the calibration and analysis of the system for components from the Rover facility. 4 refs., 2 figs., 4 tabs.

  5. Rover waste assay system

    International Nuclear Information System (INIS)

    Akers, D.W.; Stoots, C.M.; Kraft, N.C.; Marts, D.J.

    1997-01-01

    The Rover Waste Assay System (RWAS) is a nondestructive assay system designed for the rapid assay of highly-enriched 235 U contaminated piping, tank sections, and debris from the Rover nuclear rocket fuel processing facility at the Idaho Chemical Processing Plant. A scanning system translates a NaI(Tl) detector/collimator system over the structural components where both relative and calibrated measurements for 137 Cs are made. Uranium-235 concentrations are in operation and is sufficiently automated that most functions are performed by the computer system. These functions include system calibration, problem identification, collimator control, data analysis, and reporting. Calibration of the system was done through a combination of measurements on calibration standards and benchmarked modeling. A description of the system is presented along with the methods and uncertainties associated with the calibration and analysis of the system for components from the Rover facility. 4 refs., 2 figs., 4 tabs

  6. Radioreceptor assay for insulin

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Kazuo [Tokyo Univ. (Japan). Faculty of Medicine

    1975-04-01

    Radioreceptor assay of insulin was discussed from the aspects of the measuring method, its merits and problems to be solved, and its clinical application. Rat liver 10 x g pellet was used as receptor site, and enzymatic degradation of insulin by the system contained in this fraction was inhibited by adding 1 mM p-CMB. /sup 125/I-labelled porcine insulin was made by lactoperoxidase method under overnight incubation at 4/sup 0/C and later purification by Sephadex G-25 column and Whatman CF-11 cellulose powder. Dog pancreatic vein serum insulin during and after the glucose load was determined by radioreceptor assay and radioimmunoassay resulting that both measurements accorded considerably. Radioreceptor assay would clarify the pathology of disorders of glucose metabolism including diabetes.

  7. Integrated uncertainty analysis using RELAP/SCDAPSIM/MOD4.0

    International Nuclear Information System (INIS)

    Perez, M.; Reventos, F.; Wagner, R.; Allison, C.

    2009-01-01

    The RELAP/SCDAPSIM/MOD4.0 code, designed to predict the behavior of reactor systems during normal and accident conditions, is being developed as part of an international nuclear technology Software Development and Training Program (SDTP). RELAP/SCDAPSIM/MOD4.0, which is the first version of RELAP5 completely rewritten to FORTRAN 90/95/2000 standards, uses the publicly available RELAP5 and SCDAP models in combination with (a) advanced programming and numerical techniques, (b) advanced SDTP-member-developed models for LWR, HWR, and research reactor analysis, and (c) a variety of other member-developed computational packages. One such computational package is an integrated uncertainty analysis package being developed jointly by the Technical University of Catalunya (UPC) and Innovative Systems Software (ISS). The integrated uncertainty analysis approach used in the package uses the following steps: 1. Selection of the plant; 2. Selection of the scenario; 3. Selection of the safety criteria; 4. Identification and ranking of the relevant phenomena based on the safety criteria; 5. Selection of the appropriate code parameters to represent those phenomena; 6. Association of uncertainty by means of Probability Distribution Functions (PDFs) for each selected parameter; 7. Random sampling of the selected parameters according to its PDF and performing multiple computer runs to obtain uncertainty bands with a certain percentile and confidence level; 8. Processing the results of the multiple computer runs to estimate the uncertainty bands for the computed quantities associated with the selected safety criteria. The first four steps are performed by the user prior to the RELAP/SCDAPSIM/MOD4.0 analysis. The remaining steps are included with the MOD4.0 integrated uncertainty analysis (IUA) package. This paper briefly describes the integrated uncertainty analysis package including (a) the features of the package, (b) the implementation of the package into RELAP/SCDAPSIM/MOD4.0, and

  8. Clonogenic assay: adherent cells.

    Science.gov (United States)

    Rafehi, Haloom; Orlowski, Christian; Georgiadis, George T; Ververis, Katherine; El-Osta, Assam; Karagiannis, Tom C

    2011-03-13

    The clonogenic (or colony forming) assay has been established for more than 50 years; the original paper describing the technique was published in 1956. Apart from documenting the method, the initial landmark study generated the first radiation-dose response curve for X-ray irradiated mammalian (HeLa) cells in culture. Basically, the clonogenic assay enables an assessment of the differences in reproductive viability (capacity of cells to produce progeny; i.e. a single cell to form a colony of 50 or more cells) between control untreated cells and cells that have undergone various treatments such as exposure to ionising radiation, various chemical compounds (e.g. cytotoxic agents) or in other cases genetic manipulation. The assay has become the most widely accepted technique in radiation biology and has been widely used for evaluating the radiation sensitivity of different cell lines. Further, the clonogenic assay is commonly used for monitoring the efficacy of radiation modifying compounds and for determining the effects of cytotoxic agents and other anti-cancer therapeutics on colony forming ability, in different cell lines. A typical clonogenic survival experiment using adherent cells lines involves three distinct components, 1) treatment of the cell monolayer in tissue culture flasks, 2) preparation of single cell suspensions and plating an appropriate number of cells in petri dishes and 3) fixing and staining colonies following a relevant incubation period, which could range from 1-3 weeks, depending on the cell line. Here we demonstrate the general procedure for performing the clonogenic assay with adherent cell lines with the use of an immortalized human keratinocyte cell line (FEP-1811). Also, our aims are to describe common features of clonogenic assays including calculation of the plating efficiency and survival fractions after exposure of cells to radiation, and to exemplify modification of radiation-response with the use of a natural antioxidant

  9. Scintillation proximity assay

    International Nuclear Information System (INIS)

    Hart, H.

    1980-01-01

    In a method of immunological assay two different classes of particles which interact at short distances to produce characteristic detectable signals are employed in a modification of the usual latex fixation test. In one embodiment an aqueous suspension of antigen coated tritiated latex particles (LH) and antigen coated polystyrene scintillant particles (L*) is employed to assay antibody in the aqueous medium. The amount of (LH) (L*) dimer formation and higher order aggregation induced and therefore the concentration of antibody (or antigen) present which caused the aggregation can be determined by using standard liquid scintillation counting equipment. (author)

  10. Assays for calcitonin receptors

    International Nuclear Information System (INIS)

    Teitelbaum, A.P.; Nissenson, R.A.; Arnaud, C.D.

    1985-01-01

    The assays for calcitonin receptors described focus on their use in the study of the well-established target organs for calcitonin, bone and kidney. The radioligand used in virtually all calcitonin binding studies is 125 I-labelled salmon calcitonin. The lack of methionine residues in this peptide permits the use of chloramine-T for the iodination reaction. Binding assays are described for intact bone, skeletal plasma membranes, renal plasma membranes, and primary kidney cell cultures of rats. Studies on calcitonin metabolism in laboratory animals and regulation of calcitonin receptors are reviewed

  11. Feasibility of using auto Mod-MPI system, a novel technique for automated measurement of fetal modified myocardial performance index.

    Science.gov (United States)

    Lee, M-Y; Won, H-S; Jeon, E-J; Yoon, H C; Choi, J Y; Hong, S J; Kim, M-J

    2014-06-01

    To evaluate the reproducibility of measurement of the fetal left modified myocardial performance index (Mod-MPI) determined using a novel automated system. This was a prospective study of 116 ultrasound examinations from 110 normal singleton pregnancies at 12 + 1 to 37 + 1 weeks' gestation. Two experienced operators each measured the left Mod-MPI twice manually and twice automatically using the Auto Mod-MPI system. Intra- and interoperator reproducibility were assessed using intraclass correlation coefficients (ICCs) and the manual and automated measurements obtained by the more experienced operator were compared using Bland-Altman plots and ICCs. Both operators successfully measured the left Mod-MPI in all cases using the Auto Mod-MPI system. For both operators, intraoperator reproducibility was higher when performing automated measurements (ICC = 0.967 and 0.962 for Operators 1 and 2, respectively) than when performing manual measurements (ICC = 0.857 and 0.856 for Operators 1 and 2, respectively). Interoperator agreement was also better for automated than for manual measurements (ICC = 0.930 vs 0.723, respectively). There was good agreement between the automated and manual values measured by the more experienced operator. The Auto Mod-MPI system is a reliable technique for measuring fetal left Mod-MPI and demonstrates excellent reproducibility. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.

  12. A Comparison of Nuclear Power Plant Simulator with RELAP5/MOD3 code about Steam Generator Tube Rupture

    International Nuclear Information System (INIS)

    Kim, Sung Hyun; Moon, Chan Ki; Park, Sung Baek; Na, Man Gyun

    2013-01-01

    The RELAP5/MOD3 code introduced in cooperation with U. S. NRC has been utilized mainly for validation calculation of accident analysis submitted by licensee in Korea. The Korea Institute of Nuclear Safety has built a verification system of LWR accident analysis with RELAP5/MOD3 code engine. Therefore, the simulator replicates the design basis accident and its results are compared with RELAP5/MOD3 code results that will have important implications in the verification of the simulator in the future. The SGTR simulations were performed by the simulator and its results were compared with ones by RELAP5/MOD3 code in this study. Thus, the results of this study can be used as materials to build the verification system of the nuclear power plant simulator. We tried to compare with RELAP5/MOD3 verification code by replicating major parameters of steam generator tube rupture using the simulator for OPR-1000 in Yonggwang training center. By comparing the changes in temperature, pressure and inventory of the reactor coolant system and main steam system during the SGTR, it was confirmed that the main behaviors of SGTR which the simulator and RELAP5/MOD3 code showed are similar. However, the behavior of SG pressure and level that are important parameters to diagnose the accident were a little different. We estimated that RELAP5/MOD3 code was not reflected the major control systems in detail, such as FWCS, SBCS and PPCS. The different behaviors of SG level and pressure in this study should be needed an additional review. As a result of the comparison, the major simulation parameters behavior by RELAP5/MOD3 code agreed well with the one by the simulator. Therefore, it is thought that RELAP5/MOD3 code is used as a tool for validation of NPP simulator in the near future through this study

  13. Determination of Nitrate Reductase Assay Depending on the Microbial Growth

    International Nuclear Information System (INIS)

    El-Kabbany, H.M.

    2012-01-01

    A rapid micro-dilution assay for determination of the antimicrobial susceptibility of different bacterial isolates was developed. This assay is based on the ability of the most of viable organisms to reduce nitrates. The MIC or MBC could be determined by nitrate reductase (NR) only after 30 to 90 min of incubation depending on the behaviour of microbial growth. Bacterial viability is detected by a positive nitrite reduction rather than visible turbidity. The nitrate reduction assay was compared with standard micro-assay using 250 isolates of different taxa against 10 antibiotics belonging to different classes. An excellent agreement of 82.5 % was found between the two methods and only 17.5 % of 1794 trials showed difference in the determined MIC by tow-dilution interval above or below the MIC determined by the turbidimetric method under the same test conditions. However, the nitrate reduction assay was more rapid and sensitive in detecting viable bacteria and so, established an accurate estimate of the minimal inhibitory concentration (MIC) or the minimal bacterial concentration (MBC). The nitrate reduction assay offers the additional advantage that it could be used to determine the MBC without having to subculture the broth. 232 cases of resistance were detected by NR and 4 different media were tested for susceptibility test. The bacterial isolates were exposed to ultra violet (UV) light for different period

  14. Code option guideline improvement using comparisons of RELAP4/MOD6 with forced and gravity-feed reflood data. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Chen, T H; Fletcher, C D

    1978-09-01

    Improved guidelines are developed for the selection of RELAP4/MOD6 reflood heat transfer options. The development, involving modifications to the original guidelines, assessed the effect of those modifications on RELAP4/MOD6 data comparisons using previously analyzed reflood experiments. The report also presents an evaluation of the application of the revised guidelines. Data comparisons between RELAP4/MOD6, using the original and revised guidelines, and experimental data are presented for Semiscale and FLECHT, forced-feed reflood tests and Semiscale and FLECHT-SET gravity-feed reflood tests. Because a general improvement was evident in data comparisons using the revised guidelines, their use is recommended in future calculations.

  15. Lateral flow assays

    NARCIS (Netherlands)

    Posthuma-Trumpie, G.A.; Amerongen, van A.

    2012-01-01

    A simple version of immunochemical-based methods is the Lateral Flow Assay (LFA). It is a dry chemistry technique (reagents are included); the fluid from the sample runs through a porous membrane (often nitrocellulose) by capillary force. Typically the membrane is cut as a strip of 0.5*5 cm. In most

  16. Microchemiluminescent assay system

    Energy Technology Data Exchange (ETDEWEB)

    Kiel, J.L.

    1986-04-09

    The patent concerns a microchemiluminescent assay system, which can be used to detect ionizing radiation, heat or specific substances. The method involves the use of a complex formed from serum albumin and a luminescer which, in the presence of ionizing radiation (heat, or a specific analyte), will emit light in an amount proportional to the amount of radiation, etc. (U.K.).

  17. (MTT) dye reduction assay.

    African Journals Online (AJOL)

    to inhibit proliferation of HeLa cells was determined using the 3443- dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) dye reduction assay. Extracts from roots of Agathisanthemum bojeri, Synaptolepis kirkii and Zanha africana and the leaf extract of Physalis peruviana at a concentration of 10 pg/ml inhibited cell ...

  18. Hyaluronic Acid Assays

    DEFF Research Database (Denmark)

    Itenov, Theis S; Kirkby, Nikolai S; Bestle, Morten H

    2015-01-01

    BACKGROUD: Hyaluronic acid (HA) is proposed as a marker of functional liver capacity. The aim of the present study was to compare a new turbidimetric assay for measuring HA with the current standard method. METHODS: HA was measured by a particle-enhanced turbidimetric immunoassay (PETIA) and enzyme...

  19. FLUIDICS DEVICE FOR ASSAY

    DEFF Research Database (Denmark)

    2007-01-01

    The present invention relates to a device for use in performing assays on standard laboratory solid supports whereon chemical entities are attached. The invention furthermore relates to the use of such a device and a kit comprising such a device. The device according to the present invention is a...

  20. Analysis of Rod Withdrawal at Power (RWAP) Accident using ATHLET Mod 2.2 Cycle A and RELAP5/mod 3.3 Codes

    International Nuclear Information System (INIS)

    Bencik, V.; Cavlina, N.; Grgic, D.

    2012-01-01

    The system code ATHLET is being developed at Gesellschaft fuer Anlagen-und Reaktorsicherheit (GRS) in Germany. In 1996, the NPP Krsko (NEK) input deck for ATHLET Mod 1.1 Cycle C has been developed at Faculty of Electrical Engineering (FER), University of Zagreb. The input deck was tested by analyzing the realistic plant event 'Main Steam Isolation Valve Closure' and the results were assessed against the measured data. The input deck was established before plant modernization that took place in 2000 and included the power uprate and SG replacement. The released ATHLET version (Mod 2.2 Cycle A) is now being available at FER Zagreb. Accordingly, the NEK input deck for ATHLET Mod 2.2 Cycle A has been developed. A completely new input deck has been created taking into account the large number of changes due to power uprate and SG replacement as well as taking advantage of developmental work on NEK data base performed at FER. The new NEK input deck for ATHLET code has been tested by analyzing the Rod Withdrawal Power (RWAP) accident and the results were assessed against the analysis performed by RELAP5/mod 3.3 code. The RWAP accident can be either Departure from Nucleate Boiling (DNB) ratio or overpower limiting accident depending on initial power and reactivity insertion rate. Since the automatic rod control system is assumed unavailable, the only negative reactivity is due to Doppler and moderator feedback. Consequently, the nuclear power and the transferred heat in the steam generators (SGs) increase. Since the steam flow to the turbine and the extracted power from the SGs remain constant, the SG secondary pressure and the temperatures on the primary side increase. Unless terminated by manual or automatic action, the power mismatch between primary and secondary side and the resultant coolant temperature rise could eventually result in DNB ratio and/or fuel centreline melt. In order to avoid core damage, the reactor protection system is designed to automatically

  1. Calculation of pre and post-test of the third. proposed standard problem exercise, for the PMK-NVH-IAEA experiment using the RELAP4/MOD5 and RELAP5/MOD1

    International Nuclear Information System (INIS)

    Neves Conti, T. das; Sabundjian, G.; Oliveira Neto, J.M. de

    1992-01-01

    The results of RELAP4/MOD5 and RELAP5/MOD1 modeling tests against the steam generator tube rupture experiments performed at PMK-NVH Experimental Loop Facility (IAEA-Standard Problem Exercise-3) are presented in the report. The pre and post-test results, when compared against the experimental data were satisfactorily good, except a discrepancy in the steam-generator relief valve opening time. (author)

  2. Analysis of the OECD-LOFT International Standard Problem 31 using SCDAP/RELAP5/MOD3

    International Nuclear Information System (INIS)

    Hohorst, J.K.; Allison, C.M.

    1992-01-01

    The CORA-13 bundle heating and melting experiment performed at the Kernforechungszentrum, Karlaruhe, (KfK) was analyzed at the Idaho National Engineering Laboratory (INEL) using SCDAP/RELAP5/MOD3. This analysis was part of a systematic assessment of SCDAP/RELAP5/MOD3 for the US Nuclear Regulatory Commission to (a) evaluate the variances between calculated and observed behavior, (b) identify outstanding modeling deficiencies, and (c) to evaluate the impact of ongoing modeling improvements. A brief discussion of the CORA-13 experiment including a description of the facility, important test conditions, and comparisons with other CORA experimental conditions and results is provided in this report. This report describes the results of the SCDAP/RELAPS/MOD3 analysis including a description of the SCDAP/RELAPS model of the facility, base case results, sensitivity results, and a comparison with other SCDAP/RELAP5/MOD3 code-to-data comparisons

  3. Mod-5A wind turbine generator program design report. Volume 3: Final design and system description, book 2

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3MW MOD-5A wind turbine generator is documented. The report is divided into four volumes: Volume 1 summarizes the entire MOD-5A program, Volume 2 discusses the conceptual and preliminary design phases, Volume 3 describes the final design of the MOD-5A, and Volume 4 contains the drawings and specifications developed for the final design. Volume 3, book 2 describes the performance and characteristics of the MOD-5A wind turbine generator in its final configuration. The subsystem for power generation, control, and instrumentation subsystems is described in detail. The manufacturing and construction plans, and the preparation of a potential site on Oahu, Hawaii, are documented. The quality assurance and safety plan, and analyses of failure modes and effects, and reliability, availability and maintainability are presented.

  4. [Antimicrobial susceptibility in Chile 2012].

    Science.gov (United States)

    Cifuentes-D, Marcela; Silva, Francisco; García, Patricia; Bello, Helia; Briceño, Isabel; Calvo-A, Mario; Labarca, Jaime

    2014-04-01

    Bacteria antimicrobial resistance is an uncontrolled public health problem that progressively increases its magnitude and complexity. The Grupo Colaborativo de Resistencia, formed by a join of experts that represent 39 Chilean health institutions has been concerned with bacteria antimicrobial susceptibility in our country since 2008. In this document we present in vitro bacterial susceptibility accumulated during year 2012 belonging to 28 national health institutions that represent about 36% of hospital discharges in Chile. We consider of major importance to report periodically bacteria susceptibility so to keep the medical community updated to achieve target the empirical antimicrobial therapies and the control measures and prevention of the dissemination of multiresistant strains.

  5. Radioreceptor assay for oxyphenonium

    International Nuclear Information System (INIS)

    Ensing, K.; Zeeuw, R.A. de

    1984-01-01

    The development of a radioreceptor assay for the quaternary anticholinergic drug, oxyphenonium, in plasma is reported. It is based on competition between this drug and 3 H-dexetimide for binding to muscarinic receptors. After ion pair extraction and reextraction, the drug can be determined in plasma at concentrations down to a value of 100 pg/ml. This permits pharmacokinetic studies to be made after inhalation of oxyphenonium. (author)

  6. Dual isotope assays

    International Nuclear Information System (INIS)

    Smith, G.F.W.; Stevens, R.A.J.; Jacoby, B.

    1980-01-01

    Dual isotope assays for thyroid function are performed by carrying out a radio-immunoassay for two of thyroxine (T4), tri-iodothyronine (T3), thyroid stimulating hormone (TSH), and thyroxine binding globulin (TBG), by a method wherein a version of one of the thyroid components, preferably T4 or T3 is labelled with Selenium-75 and the version of the other thyroid component is labelled with a different radionuclide, preferably Iodine-125. (author)

  7. Numerical modelling of ICRF physics experiments in the Alcator C-mod tokamak

    International Nuclear Information System (INIS)

    Bonoli, P.T.; Boivin, R.L.; Brambilla, M.

    2001-01-01

    A full-wave spectral code (TORIC) has been used to simulate mode converted ion Bernstein wave (IBW) propagation and absorption for the first time at high poloidal mode number (-80< m<+80). Converged wave solutions for the mode converted wave are obtained in this limit and the predicted electron damping of the IBW is found to be consistent with experimental measurements from the Alcator C-Mod tokamak. The TORIC code has also been coupled to a bounce-averaged Fokker Planck module FPPRF and the combined codes are now run within the transport analysis tool TRANSP. This model was used to analyze off-axis hydrogen minority heating experiments in C-Mod where an internal transport barrier was obtained. (author)

  8. Investigation of RF-enhanced plasma potentials on Alcator C-Mod

    Energy Technology Data Exchange (ETDEWEB)

    Ochoukov, R., E-mail: ochoukov@psfc.mit.edu [PSFC MIT, NW17, 175 Albany Street, Cambridge, MA 02139 (United States); Whyte, D.G.; Brunner, D. [PSFC MIT, NW17, 175 Albany Street, Cambridge, MA 02139 (United States); Cziegler, I. [Center for Energy Research, UCSD, 9500 Gilman Drive, La Jolla, CA 92093 (United States); LaBombard, B.; Lipschultz, B. [PSFC MIT, NW17, 175 Albany Street, Cambridge, MA 02139 (United States); Myra, J. [Lodestar Research Corporation, 2400 Central Avenue P-5, Boulder, CO 80301 (United States); Terry, J.; Wukitch, S. [PSFC MIT, NW17, 175 Albany Street, Cambridge, MA 02139 (United States)

    2013-07-15

    Radio frequency (RF) sheath rectification is a leading mechanism suspected of causing anomalously high erosion of plasma facing materials in RF-heated plasmas on Alcator C-Mod. An extensive experimental survey of the plasma potential (Φ{sub P}) in RF-heated discharges on C-Mod reveals that significant Φ{sub P} enhancement (>100 V) is found on outboard limiter surfaces, both mapped and not mapped to active RF antennas. Surfaces that magnetically map to active RF antennas show Φ{sub P} enhancement that is, in part, consistent with the recently proposed slow wave rectification mechanism. Surfaces that do not map to active RF antennas also experience significant Φ{sub P} enhancement, which strongly correlates with the local fast wave intensity. In this case, fast wave rectification is a leading candidate mechanism responsible for the observed enhancement.

  9. Investigation of RF-enhanced plasma potentials on Alcator C-Mod

    International Nuclear Information System (INIS)

    Ochoukov, R.; Whyte, D.G.; Brunner, D.; Cziegler, I.; LaBombard, B.; Lipschultz, B.; Myra, J.; Terry, J.; Wukitch, S.

    2013-01-01

    Radio frequency (RF) sheath rectification is a leading mechanism suspected of causing anomalously high erosion of plasma facing materials in RF-heated plasmas on Alcator C-Mod. An extensive experimental survey of the plasma potential (Φ P ) in RF-heated discharges on C-Mod reveals that significant Φ P enhancement (>100 V) is found on outboard limiter surfaces, both mapped and not mapped to active RF antennas. Surfaces that magnetically map to active RF antennas show Φ P enhancement that is, in part, consistent with the recently proposed slow wave rectification mechanism. Surfaces that do not map to active RF antennas also experience significant Φ P enhancement, which strongly correlates with the local fast wave intensity. In this case, fast wave rectification is a leading candidate mechanism responsible for the observed enhancement

  10. Simulation of small break loss of coolant accident using relap 5/ MOD 2 computer code

    International Nuclear Information System (INIS)

    Megahed, M.M.

    1992-01-01

    An assessment of relap 5 / MOD 2/Cycle 36.05 best estimate computer code capabilities in predicting the thermohydraulic response of a PWR following a small break loss of coolant accident is presented. The experimental data base for the evaluation is the results of Test S-N H-3 performed in the semi scale MOD-2 c Test facility which modeled a 0.5% small break loss of coolant accident with an accompanying failure of the high pressure injection emergency core cooling system. A conclusion was reached that the code is capable of making small break loss of coolant accident calculations efficiently. However, some of the small break loss of coolant accident related phenomena were not properly predicted by the code, suggesting a need for code improvement.9 fig., 3 tab

  11. Intelligence artificielle et agents collectifs : le modèle EUROSIM

    Directory of Open Access Journals (Sweden)

    Denise Pumain

    2007-07-01

    Full Text Available EUROSIM est un modèle multi-agents conçu pour simuler l’évolution à moyen terme du système des villes européennes. Les agents sont des entités collectives, les grandes villes caractérisées par leur taille et leur fonction dans le système des villes, et dont les interactions (échanges modulés par des relations de proximité ou de réseau déterminent la dynamique relative, tandis que la croissance d’ensemble dépend de l’innovation. Des outils d’analyse multiscalaire ont été développés afin d’interpréter les sorties du modèle et faciliter le calibrage.

  12. Development of wide area reaction system for Reel-to-Reel TFA-MOD process

    International Nuclear Information System (INIS)

    Nomoto, Sukeharu; Aoki, Yuji; Teranishi, Ryo; Sato, Akihiro; Izumi, Teruo; Shiohara, Yuh

    2006-01-01

    The previously developed numerical simulation method for the TFA-MOD process, which calculated the YBCO growth kinetics, gas element diffusion and gas flow, was applied to study the suitable gas flow mode for a multi-turning Reel-to-Reel tape conveyance system of a long YBCO coated conductors. The high YBCO production rate with uniform J c distribution among tape lines is desired in the system. It was found by the numerical simulation for the vertical gas flow onto the tape surface to realize the above demands even in a wider reaction area. We developed a new wide area reaction tube for the Reel-to-Reel TFA-MOD process according to the numerically designed gas flow configuration. The demand for the new tube was confirmed to be satisfied by experiments

  13. PL-MOD: a computer code for modular fault tree analysis and evaluation

    International Nuclear Information System (INIS)

    Olmos, J.; Wolf, L.

    1978-01-01

    The computer code PL-MOD has been developed to implement the modular methodology to fault tree analysis. In the modular approach, fault tree structures are characterized by recursively relating the top tree event to all basic event inputs through a set of equations, each defining an independent modular event for the tree. The advantages of tree modularization lie in that it is a more compact representation than the minimal cut-set description and in that it is well suited for fault tree quantification because of its recursive form. In its present version, PL-MOD modularizes fault trees and evaluates top and intermediate event failure probabilities, as well as basic component and modular event importance measures, in a very efficient way. Thus, its execution time for the modularization and quantification of a PWR High Pressure Injection System reduced fault tree was 25 times faster than that necessary to generate its equivalent minimal cut-set description using the computer code MOCUS

  14. Plasma performance and scaling laws in the RFX-mod reversed-field pinch experiment

    International Nuclear Information System (INIS)

    Innocente, P.; Alfier, A.; Canton, A.; Pasqualotto, R.

    2009-01-01

    The large range of plasma currents (I p = 0.2-1.6 MA) and feedback-controlled magnetic boundary conditions of the RFX-mod experiment make it well suited to performing scaling studies. The assessment of such scaling, in particular those on temperature and energy confinement, is crucial both for improving the operating reversed-field pinch (RFP) devices and for validating the RFP configuration as a candidate for the future fusion reactors. For such a purpose scaling laws for magnetic fluctuations, temperature and energy confinement have been evaluated in stationary operation. RFX-mod scaling laws have been compared with those obtained from other RFP devices and numerical simulations. The role of the magnetic boundary has been analysed, comparing discharges performed with different active control schemes of the edge radial magnetic field.

  15. Posttest analysis of international standard problem 10 using RELAP4/MOD7

    International Nuclear Information System (INIS)

    Hsu, M.; Davis, C.B.; Peterson, A.C. Jr.; Behling, S.R.

    1981-01-01

    RELAP4/MOD7, a best estimate computer code for the calculation of thermal and hydraulic phenomena in a nuclear reactor or related system, is the latest version in the RELAP4 code development series. This paper evaluates the capability of RELAP4/MOD7 to calculate refill/reflood phenomena. This evaluation uses the data of International Standard Problem 10, which is based on West Germany's KWU PKL refill/reflood experiment K9A. The PKL test facility represents a typical West German four-loop, 1300 MW pressurized water reactor (PWR) in reduced scale while maintaining prototypical volume-to-power ratio. The PKL facility was designed to specifically simulate the refill/reflood phase of a hypothetical loss-of-coolant accident

  16. Analyses for MARIA Research Reactor with RELAP/MOD3 code

    International Nuclear Information System (INIS)

    Szczurek, J.; Czerski, P.

    2004-01-01

    This paper deals with the application of the RELAP5/MOD3 code to the transient analyses for MARIA research reactor. Poland's MARIA Research Reactor is water and beryllium moderated, water-cooled reactor of a pool type with pressurized fuel channels containing concentric multi-tube assemblies of highly enriched uranium clad in aluminium. The RELAP5/MOD3 input data model includes the whole primary cooling circuit of the MARIA reactor. The model was qualified against the reactor data at steady state conditions and additionally against the existing reliable experimental data for a transient initiated by the reactor scram. The RELAP transient simulation was performed for loss of forced flow accidents including two scenarios with protected and unprotected (no scram) reactor core. Calculations allow estimating time margin for reactor scram initiation and reactivity feedbacks contribution to the results. (author)

  17. Experiment predictions of LOFT reflood behavior using the RELAP4/MOD6 code

    International Nuclear Information System (INIS)

    Lin, J.C.; Kee, E.J.; Grush, W.H.; White, J.R.

    1978-01-01

    The RELAP4/MOD6 computer code was used to predict the thermal-hydraulic transient for Loss-of-Fluid Test (LOFT) Loss-of-Coolant Accident (LOCA) experiments L2-2, L2-3, and L2-4. This analysis will aid in the development and assessment of analytical models used to analyze the LOCA performance of commercial power reactors. Prior to performing experiments in the LOFT facility, the experiments are modeled in counterpart tests performed in the nonnuclear Semiscale MOD 1 facility. A comparison of the analytical results with Semiscale data will verify the analytical capability of the RELAP4 code to predict the thermal-hydraulic behavior of the Semiscale LOFT counterpart tests. The analytical model and the results of analyses for the reflood portion of the LOFT LOCA experiments are described. These results are compared with the data from Semiscale

  18. Assessment of PWR Steam Generator modelling in RELAP5/MOD2

    International Nuclear Information System (INIS)

    Putney, J.M.; Preece, R.J.

    1993-06-01

    An assessment of Steam Generator (SG) modelling in the PWR thermal-hydraulic code RELAP5/MOD2 is presented. The assessment is based on a review of code assessment calculations performed in the UK and elsewhere, detailed calculations against a series of commissioning tests carried out on the Wolf Creek PWR and analytical investigations of the phenomena involved in normal and abnormal SG operation. A number of modelling deficiencies are identified and their implications for PWR safety analysis are discussed -- including methods for compensating for the deficiencies through changes to the input deck. Consideration is also given as to whether the deficiencies will still be present in the successor code RELAP5/MOD3

  19. Vessel coolant mass depletion during a 5% SBLOCA in the Semiscale Mod-2C facility

    International Nuclear Information System (INIS)

    Shaw, R.A.; Loomis, G.G.

    1985-01-01

    Experimental results are presented from two 5% small-break loss-of-coolant accident (SBLOCA) simulations in the Semiscale Mod-2C facility. In performing the simulated 5% SBLOCAs, boundary conditions scaled from a pressurized water reactor (PWR) were used. The experiment was run with initial conditions typical of a PWR (15.6 MPa pressure and 35 K core differential temperature). The Mod-2C facility represents the state-of-the-art in small facilities scaled from PWRs. Phenomena which occurred during the transient included: primary fluid saturation (change from subcooled to saturated blowdown), break uncovery (a centerline break was simulated), condensation-induced liquid hold-up in the steam generator primary tubes, pump suction liquid seal formation and core level depression with resulting core rod temperature excursion, pump suction liquid seal clearance, loop fluid mass redistribution, and gradual core rewet. The influence of core bypass flow is also discussed. 11 refs., 13 figs

  20. The Role of Plasma Rotation in C-Mod Internal Transport Barriers

    Science.gov (United States)

    Fiore, C. L.; Ernst, D. R.; Rice, J. E.; Podpaly, Y.; Reinke, M. L.; Greenwald, M. J.; Hughes, J. W.; Ma, Y.; Bespamyatnov, I. O.; Rowan, W. L.

    2010-11-01

    ITBs in Alcator C-Mod featuring highly peaked density and pressure profiles are induced by injecting ICRF power with the second harmonic of the resonant frequency for minority hydrogen off-axis at the plasma half radius. These ITBs are formed in the absence of particle or momentum injection, and with monotonic q profiles with qmin ITB forms, this rotation decreases in the center of the plasma and forms a well, and often reverses direction in the core. This indicates that there is a strong EXB shearing rate in the region where the foot in the ITB density profile is observed. Preliminary gyrokinetic analyses indicate that this shearing rate is comparable to the ion temperature gradient mode (ITG) growth rate at this location and may be responsible for stabilizing the turbulence. Gyrokinetic analyses of recent experimental data obtained from a complete scan of the ICRF resonance position across the entire C-Mod plasma will be presented.

  1. Background and system description of the Mod 1 wind turbine generator

    Science.gov (United States)

    Ernst, E. H.

    1978-01-01

    The Mod-1 wind turbine considered is a large utility-class machine, operating in the high wind regime, which has the potential for generation of utility grade power at costs competitive with other alternative energy sources. A Mod-1 wind turbine generator (WTG) description is presented, taking into account the two variable-pitch steel blades of the rotor, the drive train, power generation/control, the Nacelle structure, and the yaw drive. The major surface elements of the WTG are the ground enclosure, the back-up battery system, the step-up transformer, elements of the data system, cabling, area lighting, and tower foundation. The final system weight (rotor, Nacelle, and tower) is expected to be about 650,000 pounds. The WTG will be capable of delivering 1800 kW to the utility grid in a wind-speed above 25 mph.

  2. Construction of low-cost, Mod-OA wood composite wind turbine blades

    Science.gov (United States)

    Lark, R. F.

    1983-01-01

    Two sixty-foot, low-cost, wood composite blades for service on 200 kW Mod-OA wind turbines were constructed. The blades were constructed of epoxy resin-bonded Douglas fir veneers for the leading edge sections, and paper honeycombcored, birch plywood faced panels for the afterbody sections. The blades were joined to the wind turbine hub by epoxy resin-bonded steel load take-off studs embedded into the root end of the blades. The blades were installed on the 200 kW Mod-OA wind turbine facility at Kahuku, Hawaii, The blades completed nearly 8,000 hours of operation over an 18 month period at an average power of 150 kW prior to replacement with another set of wood composite blades. The blades were replaced because of a corrosion failure of the steel shank on one stud. Inspections showed that the wood composite structure remained in excellent condition.

  3. Modeling of BWR core meltdown accidents - for application in the MELRPI. MOD2 computer code

    Energy Technology Data Exchange (ETDEWEB)

    Koh, B R; Kim, S H; Taleyarkhan, R P; Podowski, M Z; Lahey, Jr, R T

    1985-04-01

    This report summarizes improvements and modifications made in the MELRPI computer code. A major difference between this new, updated version of the code, called MELRPI.MOD2, and the one reported previously, concerns the inclusion of a model for the BWR emergency core cooling systems (ECCS). This model and its computer implementation, the ECCRPI subroutine, account for various emergency injection modes, for both intact and rubblized geometries. Other changes to MELRPI deal with an improved model for canister wall oxidation, rubble bed modeling, and numerical integration of system equations. A complete documentation of the entire MELRPI.MOD2 code is also given, including an input guide, list of subroutines, sample input/output and program listing.

  4. Blowdown heat transfer surface in RELAP4/MOD6 and data comparisons

    International Nuclear Information System (INIS)

    Nelson, R.A.; Sullivan, L.H.

    1978-01-01

    RELAP4 is a thermal hydraulic analysis tool written to analyze transients in light water reactors (LWR). To date, most of the applications for RELAP4 have been to analyze postulated LOCA transients in LWR and the response of experimental systems to loss-of-coolant experiments. An important part of these analyses is the prediction of the fuel rod or heater surface temperature which involves the calculation of surface heat transfer coefficients. The paper describes the outcome of a significant blowdown heat transfer development effort which is incorporated in RELAP4/MOD6 (the current version of the code available to the United States public from the Argonne Code Center). The primary emphasis in the MOD6 development was on a PWR reflood capability. The best-estimate blowdown heat transfer correlation and logic were added to provide improved blowdown predictive capability

  5. Vectorization of LWR transient analysis code RELAP5/MOD1 and its effect

    International Nuclear Information System (INIS)

    Ishiguro, Misako; Harada, Hiroo; Shinozawa, Naohisa; Naraoka, Ken-itsu

    1985-03-01

    The RELAP5/MOD1 is a large thermal-hydraulic code to analyze LWR LOCA and non-LOCA transients. The code originally was designed for use on a CDC Cyber-176. This report documents vectorization of the RELAP5/MOD1 code conducted for the purpose of efficient use of VP-100 (peak speed 250 MFLOPS, clock period 7.5 ns) at the JAERI. The code was vectorized using the junction and volume level parallelisms in the hydrodynamic calculations, and the heat-structure and heat-mesh level in the heat conduction calculations. The vectorized version runs as much as 2.4 to 2.8 times faster than the original scalar version, while the speedup ratio is dependent on the number of spactial cells included in the problem. (author)

  6. RELAP4/MOD6 analysis of forced- and gravity-feed reflood tests

    International Nuclear Information System (INIS)

    Chen, T.H.; Fletcher, C.D.

    1980-01-01

    The RELAP4/MOD6 computer code is used for the analysis of the reactor core heat transfer during the reflooding phase of a postulated loss-of-coolant accident (LOCA) in a pressurized water reactor (PWR). The code requires the user to specify input parameters for the reflood heat transfer models. Results of previous comparisons of code calculations with experimental data have indicated no single selection of input parameters is adequate for a spectrum of tests and test facilities. This paper presents the development of revised quidelines and assesses the effect of those modifications on RELAP4/MOD6 data comparisons using previously analyzed reflood experiments. The paper also presents an assessment of the revised guidelines and the original guidelines against experimental data significantly different from previously analyzed tests

  7. Modélisation du comportement et des couplages HMC des milieux poreux

    OpenAIRE

    Hoang , Ha

    2012-01-01

    Modelling of the behavior and the couplings HMC of the porous circles; La modélisation du comportement hydromécanique chimique des milieux poreux saturés et non saturés est abordée au niveau microscopique et mésoscopique. Au niveau microscopique la modélisation des écoulements diphasiques est basée sur une représentation du réseau poral comme un ensemble de tubes dont les orientations et les rayons sont choisis sur un principe d’équivalence avec les pores. L’algorithme régissant la génération...

  8. A study of the dispersed flow interfacial heat transfer model of RELAP5/MOD2.5 and RELAP5/MOD3

    Energy Technology Data Exchange (ETDEWEB)

    Andreani, M. [Swiss Federal Institute of Technology, Zurich (Switzerland); Analytis, G.T.; Aksan, S.N. [Paul Scherrer Institute, Villigen (Switzerland)

    1995-09-01

    The model of interfacial heat transfer for the dispersed flow regime used in the RELAP5 computer codes is investigated in the present paper. Short-transient calculations of two low flooding rate tube reflooding experiments have been performed, where the hydraulic conditions and the heat input to the vapour in the post-dryout region were controlled for the predetermined position of the quench front. Both RELAP5/MOD2.5 and RELAP5/MOD3 substantially underpredicted the exit vapour temperature. The mass flow rate and quality, however, were correct and the heat input to the vapour was larger than the actual one. As the vapour superheat at the tube exit depends on the balance between the heat input from the wall and the heat exchange with the droplets, the discrepancy between the calculated and the measured exit vapour temperature suggested that the inability of both codes to predict the vapour superheat in the dispersed flow region is due to the overprediction of the interfacial heat transfer rate.

  9. Relap4/SAS/Mod5 - A version of Relap4/Mod 5 adapted to IPEN/CNEN - SP computer center

    International Nuclear Information System (INIS)

    Sabundjian, G.

    1988-04-01

    In order to improve the safety of nuclear reactor power plants several computer codes have been developed in the area of thermal - hydraulics accident analysis. Among the public-available codes, RELAP4, developed by Aerojet Nuclear Company, has been the most popular one. RELAP4 has produced satisfactory results when compared to most of the available experimental data. The purposes of the present work are: optimization of RELAP4 output and messages by writing there information in temporary records, - display of RELAP4 results in graphical form through the printer. The sample problem consists on a simplified model of a 150 MW (e) PWR whose primary circuit is simulated by 6 volumes, 8 junctions and 1 heat slab. This new version of RELAP4 (named RELAP4/SAS/MOD5) have produced results which show that the above mentioned purposes have been reached. Obviously the graphical output by RELAP4/SAS/MOD5 favors the interpretation of results by the user. (author) [pt

  10. Conception d’un automate cellulaire non stationnaire à base de graphe pour modéliser la structure spatiale urbaine: le modèle Remus

    Directory of Open Access Journals (Sweden)

    Arnaud Banos

    2007-10-01

    Full Text Available Nous proposons dans cet article une formalisation originale des automates cellulaires géographiques, à même de mieux prendre en compte grâce à une structure de graphe le voisinage irrégulier et dynamique d’entités spatiales. Le modèle Remus permet ainsi de représenter sous la forme d’un graphe mathématique les entités spatiales du bâti et les réseaux de transport urbain (graphe urbain ; il permet aussi de calculer la distance-temps entre bâtiments par le réseau. Le modèle Remus permet l’extraction de différents graphes, dont le graphe fonctionnel des distances-temps entre les immeubles et le graphe de relations de voisinage qui représente le voisinage par le réseau pour un certain seuil de temps de trajet et pour un mode de transport donné.

  11. Improvement and validation of the wall heat transfer package of RELAP5/MOD3.3

    International Nuclear Information System (INIS)

    Wu, Pan; Xiong, Xiaofei; Shan, Jianqiang; Gou, Junli; Zhang, Bin; Zhang, Bo

    2016-01-01

    Highlights: • A new heat transfer package has been developed. • It has been incorporated into RELAP5/MOD3.3 to verify its advantages. • The results of modified code were compared with available experimental data. • The results showed that higher prediction accuracy was achieved. - Abstract: The process of energy transfer from heat structure to control volume is determined by the wall-to-fluid heat transfer package, which is crucial for nuclear reactor safety analysis codes. The current logic for selection of heat transfer modes of RELAP5/MOD3.3 code is too complex and may result in incorrect heat transfer mode judgment. Also, the narrow application scope of film boiling heat transfer correlations may result in large errors in film boiling region which is of paramount importance for the predicted peak clad temperatures during hypothetical LB-LOCAs in PWRs. In this study, a new heat transfer package has been developed and incorporated into the RELAP5/MOD3.3 code. Differing from the original package, the modified one consists of twelve heat transfer modes and proposes a new logic for selection of heat transfer modes. For each mode, the models in the existing safety analysis codes and the leading models in literature have been reviewed in order to determine the best model which can easily be applicable to the RELAP5/MOD3.3 code. Particularly (1) a new package of heat transfer correlations are produced; (2) a new logic for selection of film boiling and transition boiling heat transfer modes is proposed which use minimum film boiling temperature and critical heat flux temperature as distinguished points. The modified code has been validated by comparing the analysis results with available experimental data from tube post dryout experiments and loss-of-fluid test (LOFT) facility. The calculation results showed that the improved package could better predict the experimental phenomena with higher prediction accuracy.

  12. Assessment of TRAC-BD1/MOD1 using FIST data

    International Nuclear Information System (INIS)

    Jo, J.H.; Connell, H.R.

    1985-01-01

    This report is concerned with the assessment of the TRAC-BD1/MOD1 Code, developed at Idaho National Engineering Laboratory. The assessment was conducted using data from the FIST (Full Integral Simulation Test) facility, which is a BWR safety test facility which was built to investigate small break LOCA and operational transients in BWR's and to complement earlier large break LOCA test results from TLTA (Two-Loop Test Apparatus). 21 figs

  13. A containment convective loop analysis using the RELAP5-Mod 3.2

    International Nuclear Information System (INIS)

    Ventura, M.

    1996-01-01

    The present study was performed to verify the RELAP5-Mod 3.2 code capability to calculate convection phenomena of the type occurring in a convective loop. A simplified geometrical model of a reactor containment system was used. The parametric studies were made for the main variables which govern material transport in the volume junctions considered. The results obtained and that got using the same model with the CONTAIN code, were compared. The comparison is satisfactory. (author). 3 refs., 11 figs

  14. Se servir de la modélisation pour lutter contre les maladies ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    En se fondant sur des données émanant des activités de recherche et de surveillance du National Center for AIDS/STD Control and Prevention de la Chine, l'équipe de recherche s'emploie à concevoir des modèles propres à certaines maladies, en commençant par l'infection au VIH. Après avoir déterminé les différents ...

  15. Improvement and validation of the wall heat transfer package of RELAP5/MOD3.3

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Pan; Xiong, Xiaofei; Shan, Jianqiang, E-mail: jqshan@mail.xjtu.edu.cn; Gou, Junli; Zhang, Bin; Zhang, Bo

    2016-12-15

    Highlights: • A new heat transfer package has been developed. • It has been incorporated into RELAP5/MOD3.3 to verify its advantages. • The results of modified code were compared with available experimental data. • The results showed that higher prediction accuracy was achieved. - Abstract: The process of energy transfer from heat structure to control volume is determined by the wall-to-fluid heat transfer package, which is crucial for nuclear reactor safety analysis codes. The current logic for selection of heat transfer modes of RELAP5/MOD3.3 code is too complex and may result in incorrect heat transfer mode judgment. Also, the narrow application scope of film boiling heat transfer correlations may result in large errors in film boiling region which is of paramount importance for the predicted peak clad temperatures during hypothetical LB-LOCAs in PWRs. In this study, a new heat transfer package has been developed and incorporated into the RELAP5/MOD3.3 code. Differing from the original package, the modified one consists of twelve heat transfer modes and proposes a new logic for selection of heat transfer modes. For each mode, the models in the existing safety analysis codes and the leading models in literature have been reviewed in order to determine the best model which can easily be applicable to the RELAP5/MOD3.3 code. Particularly (1) a new package of heat transfer correlations are produced; (2) a new logic for selection of film boiling and transition boiling heat transfer modes is proposed which use minimum film boiling temperature and critical heat flux temperature as distinguished points. The modified code has been validated by comparing the analysis results with available experimental data from tube post dryout experiments and loss-of-fluid test (LOFT) facility. The calculation results showed that the improved package could better predict the experimental phenomena with higher prediction accuracy.

  16. Optimisation de modèles de propagation à partir des données de ...

    African Journals Online (AJOL)

    optimisation radio dans les réseaux mobiles. Le présent article présente une étude comparative de cinq méthodes d'optimisation de modèles de propagation à savoir : La régression linéaire, la méthode de Newton de second ordre, le recuit ...

  17. Calculation of behaviour of the Juragua NPP containment with code TRACOV/MOD1

    International Nuclear Information System (INIS)

    Castillo Alvarez, J.; Valle Cepero, R.; Luis, J.; San Roman, J.C.; Pomier, L.

    1996-01-01

    The containment of Juragua NPP has some unique features, which differ from the rest of the PWR reactors design. Those features impose additional requirements for its numerical simulation. In this paper is analyzed the behaviour of the Juragua NPP containment during accident situation with double ended break of the primary pipelines with flow in both direction using the code TRACOV/MOD1. The results are compared with obtained by the designer. The main restrictions of the code are identified

  18. Transient simulation of ALWR passive safety systems using RELAP5/MOD2

    International Nuclear Information System (INIS)

    Elias, E.; Nekhamkin, Y.; Arshavski, I.

    2004-01-01

    Numerical simulation is presented of some passive safety systems currently incorporated in the design of the next generation advanced light water reactors (ALWRs). The performance and effectiveness of ex-core natural convection cooling and the concept of gravity driven water injection at high pressure are investigated using the RELAP5/MOD2 thermal-hydraulic code. The study identifies areas that should be investigated more fully in future experimental programs related to hypothetical large and small LOCA in ALWRs. (author)

  19. A CO2 laser polarimeter for measurement of plasma current profile in Alcator C-Mod

    International Nuclear Information System (INIS)

    Ma, C.H.; Hutchinson, D.P.; Richards, R.K.; Irby, J.; Luke, T.

    1994-01-01

    A multichannel infrared polarimeter system for measurement of the plasma current profile in Alcator C-Mod has been designed, constructed, and tested. The system utilizes a cw CO 2 , laser at a wavelength of 10.6 μm. An electro-optic polarization-modulation technique has been used to achieve the high sensitivity required for the measurement. The recent results of the measurements as well as the feasibility of its application on ITER are presented

  20. Méditerranée asiatique : un modèle urbain polycentrique

    OpenAIRE

    Gipouloux , François

    2012-01-01

    Publication de la revue "Diplomatie. Affaires stratégiques et relations internationales" http://www.diplomatie-presse.com/; International audience; En Asie orientale, un corridor maritime a pris forme autour de plates-formes logistiques et portuaires, fidèles au modèle de Hong Kong. C'est là que bat le coeur de l'économie régionale.

  1. High Speed Images of Edge Plasmas in NSTX and Alcator C-Mod

    International Nuclear Information System (INIS)

    Maqueda, R.J.; Grulke, O.; Terry, J.L.; Zweben, S.J.

    2007-01-01

    This talk will describe the high speed imaging diagnostics on NSTX and Alcator C-Mod and show movies of various edge phenomena, including turbulence during L-modes and H modes, L-H and H-L transitions, effects of MHD activity and ELMs of various types, and wide angle views of the toroidal vs. poloidal structure of these edge '' filaments ''. Issues concerning the interpretation of these images will be discussed. (author)

  2. Vertical downward subcooled bubbly flow modelling with RELAP5/MOD3.2.2 gamma

    International Nuclear Information System (INIS)

    Ristevski, R.; Parzer, I.; Markov, Z.

    2000-01-01

    The presented paper will consider the correlation for void fraction distribution in the subcooled boiling flow regime of downward liquid flow at low velocities. More specifically, it will focus on the choice of the most appropriate heat and mass transfer correlation. The experimental findings and theoretical consideration of these processes and phenomena will be compared with RELAP5/MOD3.2.2 Gamma predictions. (author)

  3. Assessment of Human Bio-Behavior During Gait Process Using LifeMOD Software

    Directory of Open Access Journals (Sweden)

    Liliana Rogozea

    2011-01-01

    Full Text Available In this paper we present a set of observations concerning the
    analysis and assessment of human bio-behavior during gait process. In the first part of the paper the fundamental and theoretical considerations of the gait process are approached and aspects connected to malfunctions are expressed. In the second part of the paper we present the modeling methodology using
    the LifeMOD software, while in the third part the results and conclusions are presented.

  4. Calculations of Changes in Reactivity during some regular periods of operation of JEN-1 MOD Reactor

    International Nuclear Information System (INIS)

    Alcala Ruiz, F.

    1973-01-01

    By a Point-Reactor model and Perturbation Theory, changes in reactivity during some regular operating periods of JEN-1 MOD Reactor have been calculated and compared with available measured values. they were in good agreement. Also changes in reactivity have been calculated during operations at higher power levels than the present one, concluding some practical consequences for the case of increasing the present power of this reactor. (Author)

  5. Combining MOD10A1 and MYD10A1 Images For Snow Cover Area Monitoring

    Science.gov (United States)

    Tekeli, A. E.

    2008-12-01

    MOD10A1 and MYD10A1 daily snow cover maps at 500 m resolution are available from MODIS sensors on Terra and Aqua satellites. Aqua obtains the image of same region approximately three hours after Terra over Turkey region. MODIS is an optic sensor and cloud cover degrades the usability of derived snow cover maps. Moreover, spectral similarity between clouds and snow complicates their separability in visible imagery. Fortunately, dynamic behavior of clouds enables their discrimination from snow stationary on the surface. Combined use of MOD10A1 and MYD10A1 images mostly reduces the cloud cover present in one image alone and provides better representation of surface snow cover. Comparison of merged images with in situ data indicated higher hit ratios. The individual comparison of MOD10A1 and MYD10A1 images with ground data each yielded 31% hit ratio whereas, the merged images provided 38%. One-day shifts in comparisons increased hit ratios to 52 % and 46% whereas and two-day shifts gave 77 % and 79 % for MOD10A1 and MYD10A1 respectively. Merged maps yielded 54% and 83% for one and two day shifts. The improvement provided by the merging technique is found to be 7% for the present day, 7 % for one- day and 5% for two-day shifts for the whole season. Monthly decomposition resulted 25% improvement as the maximum. The snow cover product obtained by merging Terra and Aqua satellites provided higher hit ratios, as expected.

  6. Tableaux et modèles: «vive la sintayse»

    Directory of Open Access Journals (Sweden)

    Christian GERMANAZ

    1994-09-01

    Full Text Available L’image géographique et la peinture présentent beaucoup de similitudes. Il est possible d’analyser l’image picturale sous l’angle de la modélisation. Par l’intermédiaire de la chorématique une équivalence dans le langage plastique et pictural a été trouvée Le Christ jaune de Gauguin permet de tester cette transposition.

  7. Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 3

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. This volume contains the drawings and specifications developed for the final design. This volume is divided into 5 books of which this is the third, containing drawings 47A380074 through 47A380126. A full breakdown parts listing is provided as well as a where used list.

  8. MOD-AGE - an algorithm for age-depth model construction; U-series dated speleothems case study

    Science.gov (United States)

    Hercman, H.; Pawlak, J.

    2012-04-01

    We present MOD-AGE - a new system for chronology construction. MOD-AGE can be used for profiles that have been dated by different methods. As input data, the system uses the following basic measurements: activities, atomic ratios or age, as well as depth measurement. Based on probability distributions describing the measurement results, MOD-AGE estimates the age~depth relation and its confidence bands. To avoid the use of difficult-to-meet assumptions, MOD-AGE uses nonparametric methods. We applied a Monte Carlo simulation to model age and depth values based on the real distribution of counted data (activities, atomic ratios, depths etc.). Several fitting methods could be applied for estimating the relationships; based on several tests, we decide to use LOESS method (locally weighted scatterplot smoothing). The stratigraphic correction procedure applied in the MOD-AGE program uses a probability calculus, which assumes that the ages of all the samples are correctly estimated. Information about the probability distribution of the samples' ages is used to estimate the most probable sequence that is concordant according to the superposition rule. MOD-AGE is presented as a tool for the chronology construction of speleothems that have been analyzed by the U-series method, and it is compared to the StalAge algorithm presented by D. Scholtz and D.L Hoffmann (2011). Scholtz, D., Hoffmann, D. L., 2011. StalAge - An algorithm designed for construction of speleothem age models. Quaternary Geochronology 6, 369-382.

  9. A new formulation of the law of octic reciprocity for primes ≡±3(mod8 and its consequences

    Directory of Open Access Journals (Sweden)

    Richard H. Hudson

    1982-01-01

    Full Text Available Let p and q be odd primes with q≡±3(mod8, p≡1(mod8=a2+b2=c2+d2 and with the signs of a and c chosen so that a≡c≡1(mod4. In this paper we show step-by-step how to easily obtain for large q necessary and sufficient criteria to have (−1(q−1/2q(p−1/8≡(a−bd/acj(modp for j=1,…,8 (the cases with j odd have been treated only recently [3] in connection with the sign ambiguity in Jacobsthal sums of order 4. This is accomplished by breaking the formula of A.E. Western into three distinct parts involving two polynomials and a Legendre symbol; the latter condition restricts the validity of the method presented in section 2 to primes q≡3(mod8 and significant modification is needed to obtain similar results for q≡±1(mod8. Only recently the author has completely resolved the case q≡5(mod8, j=1,…,8 and a sketch of the method appears in the closing section of this paper.

  10. Ancestral susceptibility to colorectal cancer

    Czech Academy of Sciences Publication Activity Database

    Huhn, S.; Pardini, Barbara; Naccarati, Alessio; Vodička, Pavel (ed.); Hemminki, K.; Försti, A.

    2012-01-01

    Roč. 27, č. 2 (2012), s. 197-204 ISSN 0267-8357 R&D Projects: GA ČR GA310/07/1430; GA ČR GAP304/10/1286 Grant - others:EU FP7(XE) HEALTH-F4-2007-200767 Institutional research plan: CEZ:AV0Z50390512 Keywords : cancer susceptibility * molecular epidemiology * genetic susceptibility Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.500, year: 2012

  11. Prise en compte des ``courants de London'' dans la modélisation des supraconducteurs

    Science.gov (United States)

    Bossavit, Alain

    1997-10-01

    A model is given, in variational form, in which volumic “Bean currents”, ruled by Bean's law, and surface “London currents” coexist. This macroscopic model generalizes Bean's one, by appending to the critical density j_c a second parameter, with the dimension of a length, similar to London's depth λ. The one-dimensional version of the model is investigated, in order to link this parameter with the standard observable H-M characteristics On propose un modèle, sous forme variationnelle, associant des “courants de Bean” volumiques, décrits par la loi de Bean, et des “courants de London”, surfaciques. Ce modèle macroscopique généralise celui de Bean, caractérisé par le courant critique j_c, et fait intervenir un second paramètre, homogène à une longueur, analogue au λ de London. La version unidimensionnelle du modèle est étudiée en détail de manière à relier ce paramètre à l'observation des caractéristiques H-M usuelles.

  12. Experiments and Simulations of ITER-like Plasmas in Alcator C-Mod

    International Nuclear Information System (INIS)

    Wilson, R.; Kessel, C.E.; Wolfe, S.; Hutchinson, I.H.; Bonoli, P.; Fiore, C.; Hubbard, A.E.; Hughes, J.; Lin, Y.; Ma, Y.; Mikkelsen, D.; Reinke, M.; Scott, S.; Sips, A.C.C.; Wukitch, S.

    2010-01-01

    Alcator C-Mod is performing ITER-like experiments to benchmark and verify projections to 15 MA ELMy H-mode Inductive ITER discharges. The main focus has been on the transient ramp phases. The plasma current in C-Mod is 1.3 MA and toroidal field is 5.4 T. Both Ohmic and ion cyclotron (ICRF) heated discharges are examined. Plasma current rampup experiments have demonstrated that (ICRF and LH) heating in the rise phase can save voltseconds (V-s), as was predicted for ITER by simulations, but showed that the ICRF had no effect on the current profile versus Ohmic discharges. Rampdown experiments show an overcurrent in the Ohmic coil (OH) at the H to L transition, which can be mitigated by remaining in H-mode into the rampdown. Experiments have shown that when the EDA H-mode is preserved well into the rampdown phase, the density and temperature pedestal heights decrease during the plasma current rampdown. Simulations of the full C-Mod discharges have been done with the Tokamak Simulation Code (TSC) and the Coppi-Tang energy transport model is used with modified settings to provide the best fit to the experimental electron temperature profile. Other transport models have been examined also.

  13. Second Generation HTs Wire Based on RABiTS Substrates and MOD YBCO

    Energy Technology Data Exchange (ETDEWEB)

    Schoop, U. [American Superconductor Corporation, Westborough, MA; Rupich, Marty [American Superconductor Corporation, Westborough, MA; Thieme, C. L. H. [American Superconductor Corporation, Westborough, MA; Verebelyi, D. T. [American Superconductor Corporation, Westborough, MA; Zhang, W. [American Superconductor Corporation, Westborough, MA; Li, Xiaoping [American Superconductor Corporation, Westborough, MA; Kodenkandath, Thomas [American Superconductor Corporation, Westborough, MA; Nguyen, N. [American Superconductor Corporation, Westborough, MA; Siegal, E. E. [American Superconductor Corporation, Westborough, MA; Civale, L. [Los Alamos National Laboratory (LANL); Holesinger, T. G. [Los Alamos National Laboratory (LANL); Maiorov, B. [Los Alamos National Laboratory (LANL); Goyal, Amit [ORNL; Paranthaman, Mariappan Parans [ORNL

    2005-01-01

    The performance of Second Generation (2G) high temperature superconducting wire manufactured by continuous reel-to-reel processes is nearing the 300 A/cm-width (77 K, self field) performance threshold for commercial power cable applications. The 2G manufacturing approach under development at American Superconductor is based on the combination of the RABiTS substrate-buffer technology with metal organic deposition (MOD) of the YBCO layer. The capability of this process has been demonstrated in multiple 10 meter lengths with critical currents exceeding 250 A/cm-width with high uniformity and reproducibility. Critical currents of 380 A/cm-width have been achieved in short length samples prepared by the same basic process. The incorporation of nanoparticles ('nanodots') into the YBCO layer using the MOD process has resulted in a 2-fold improvement in the critical current at 65 K in a 3 T field. The research and development focus at ASMC is now directed toward the economical scale-up of the RABiTS/MOD process, optimization of the conductor properties for targeted applications and the use of 2G wire in initial demonstration applications.

  14. Experiment data report for semiscale Mod-1 Test S-06-5. (LOFT counterpart test)

    International Nuclear Information System (INIS)

    1977-06-01

    Recorded test data are presented for Test S-06-5 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-5 was conducted from initial conditions of 2272 psia and 536 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold legs of the intact and broken loops to simulate emergency core coolant injection in a PWR. The purpose of Test S-06-5 was to assess the influence of the break nozzle geometry on core thermal and system response and on the subcooled and low quality mass flow rates at the break locations

  15. Implementation of JAERI's reflood model into TRAC-PF1/MOD1 code

    International Nuclear Information System (INIS)

    Akimoto, Hajime; Ohnuki, Akira; Murao, Yoshio

    1993-02-01

    Selected physical models of REFLA code, that is a reflood analysis code developed at JAERI, were implemented into the TRAC-PF1/MOD1 code in order to improve the predictive capability of the TRAC-PF1/MOD1 code for the core thermal hydraulic behaviors during the reflood phase in a PWR LOCA. Through comparisons of physical models between both codes, (1) Murao-Iguchi void fraction correlation, (2) the drag coefficient correlation acting to drops, (3) the correlation for wall heat transfer coefficient in the film boiling regime, (4) the quench velocity correlation and (5) heat transfer correlations for the dispersed flow regime were selected from the REFLA code to be implemented into the TRAC-PF1/MOD1 code. A method for the transformation of the void fraction correlation to the equivalent interfacial friction model was developed and the effect of the transformation method on the stability of the solution was discussed. Through assessment calculation using data from CCTF (Cylindrical Core Test Facility) flat power test, it was confirmed that the predictive capability of the TRAC code for the core thermal hydraulic behaviors during the reflood can be improved by the implementation of selected physical models of the REFLA code. Several user guidelines for the modified TRAC code were proposed based on the sensitivity studies on fluid cell number in the hydraulic calculation and on node number and effect of axial heat conduction in the heat conduction calculation of fuel rod. (author)

  16. Assessment of TRAC-PF1/MOD1 code for large break LOCA in PWR

    International Nuclear Information System (INIS)

    Akimoto, Hajime; Ohnuki, Akira; Murao, Yoshio; Abe, Yutaka.

    1993-03-01

    As the first step of the REFLA/TRAC code development, the TRAC/PF1/MOD1 code has been assessed for various experiments that simulate postulated large-break loss-of-coolant accident (LBLOCA) in PWR to understand the predictive capability and to identify the problem areas of the code. The assessment calculations were performed for separate effect tests for critical flow, counter current flow, condensation at cold leg and reflood as well as integral tests to understand predictability for individual phenomena. This report summarizes results from the assessment calculations of the TRAC-PF1/MOD1 code for LBLOCA in PWR. The assessment calculations made clear the predictive capability and problem areas of the TRAC-PF1/MOD1 code for LBLOCA in PWR. The areas, listed below, should be improved for more realistic and effective simulation of LBLOCA in PWR: (1) core heat transfer model during blowdown, (2) ECC bypass model at downcomer during refill, (3) condensation model during accumulator injection, and (4) core thermal hydraulic model during reflood. (author) 57 refs

  17. Radon transport modelling: User's guide to RnMod3d

    International Nuclear Information System (INIS)

    Andersen, C.E.

    2000-08-01

    RnMod3d is a numerical computer model of soil-gas and radon transport in porous media. It can be used, for example, to study radon entry from soil into houses in response to indoor-outdoor pressure differences or changes in atmospheric pressure. It can also be used for flux calculations of radon from the soil surface or to model radon exhalation from building materials such as concrete. The finite-volume model is a technical research tool, and it cannot be used meaningfully without good understanding of the involved physical equations. Some understanding of numerical mathematics and the programming language Pascal is also required. Originally, the code was developed for internal use at Risoe only. With this guide, however, it should be possible for others to use the model. Three-dimensional steady-state or transient problems with Darcy flow of soil gas and combined generation, radioactive decay, diffusion and advection of radon can be solved. Moisture is included in the model, and partitioning of radon between air, water and soil grains (adsorption) is taken into account. Most parameters can change in time and space, and transport parameters (diffusivity and permeability) may be anisotropic. This guide includes benchmark tests based on simple problems with known solutions. RnMod3d has also been part of an international model intercomparison exercise based on more complicated problems without known solutions. All tests show that RnMod3d gives results of good quality. (au)

  18. Web based electronic logbook and experiment run database viewer for Alcator C-Mod

    International Nuclear Information System (INIS)

    Fredian, T.W.; Stillerman, J.A.

    2006-01-01

    Since 1991, the scientists and engineers at the Alcator C-Mod experiment at MIT have been recording text entries about the experiments being performed in an electronic logbook. In addition, separate documents such as run plans, run summaries and experimental proposals have been created and stored in a variety of formats in computer files. This information has now been organized and made available via any modern web browser. The new web based interface permits the user to browse through all the logbook entries, run information and even view some key data traces of the experiment. Since this information is being catalogued by Internet search engines, these tools can also be used to quickly locate information. The web based logbook and run information interface provides some additional capabilities. Once logged into the web site, users can add, delete or modify logbook entries directly from their browser. The logbook window on their browser also provides dynamic updating when any new logbook entries are made. There is also live C-Mod operation status information with optional audio announcements available. The user can receive the same state change announcements such as 'entering init' or 'entering pulse' as they would if they were sitting in the C-Mod control room. This paper will describe the functionality of the web based logbook and how it was implemented

  19. Radon transport modelling: User's guide to RnMod3d

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, C.E

    2000-08-01

    RnMod3d is a numerical computer model of soil-gas and radon transport in porous media. It can be used, for example, to study radon entry from soil into houses in response to indoor-outdoor pressure differences or changes in atmospheric pressure. It can also be used for flux calculations of radon from the soil surface or to model radon exhalation from building materials such as concrete. The finite-volume model is a technical research tool, and it cannot be used meaningfully without good understanding of the involved physical equations. Some understanding of numerical mathematics and the programming language Pascal is also required. Originally, the code was developed for internal use at Risoe only. With this guide, however, it should be possible for others to use the model. Three-dimensional steady-state or transient problems with Darcy flow of soil gas and combined generation, radioactive decay, diffusion and advection of radon can be solved. Moisture is included in the model, and partitioning of radon between air, water and soil grains (adsorption) is taken into account. Most parameters can change in time and space, and transport parameters (diffusivity and permeability) may be anisotropic. This guide includes benchmark tests based on simple problems with known solutions. RnMod3d has also been part of an international model intercomparison exercise based on more complicated problems without known solutions. All tests show that RnMod3d gives results of good quality. (au)

  20. Comparison of tungsten nano-tendrils grown in Alcator C-Mod and linear plasma devices

    International Nuclear Information System (INIS)

    Wright, G.M.; Brunner, D.; Baldwin, M.J.; Bystrov, K.; Doerner, R.P.; Labombard, B.; Lipschultz, B.; De Temmerman, G.; Terry, J.L.; Whyte, D.G.; Woller, K.B.

    2013-01-01

    Growth of tungsten nano-tendrils (“fuzz”) has been observed for the first time in the divertor region of a high-power density tokamak experiment. After 14 consecutive helium L-mode discharges in Alcator C-Mod, the tip of a tungsten Langmuir probe at the outer strike point was fully covered with a layer of nano-tendrils. The depth of the W fuzz layer (600 ± 150 nm) is consistent with an empirical growth formula from the PISCES experiment. Re-creating the C-Mod exposures as closely as possible in Pilot-PSI experiment can produce nearly-identical nano-tendril morphology and layer thickness at surface temperatures that agree with uncertainties with the C-Mod W probe temperature data. Helium concentrations in W fuzz layers are measured at 1–4 at.%, which is lower than expected for the observed sub-surface voids to be filled with several GPa of helium pressure. This possibly indicates that the void formation is not pressure driven

  1. The design of a second harmonic tangential array interferometer for C-Mod

    International Nuclear Information System (INIS)

    Bretz, N.; Jobes, F.; Irby, J.

    1997-01-01

    A design for a tangential array interferometer for C-Mod operating at 1.06 and 0.53 μm is presented. This is a special type of two color interferometer in which a Nd:YAG laser is frequency doubled in a nonlinear crystal. Because the doubling efficiency is imperfect, two frequencies propagate collinearly through the plasma after which the 1.06 μm ray is doubled again mixing in the optical domain with the undoubled ray. The resulting interference is insensitive to path length but is affected by plasma dispersion in the usual way. A typical central fringe shift in C-Mod is expected to be 0.1 endash 1.0, but the absolute and relative accuracy in n e l measurements can be as high as in a conventional interferometer. This design uses a repetitively pulsed laser which is converted to a fan beam crossing the horizontal midplane. The chordal array is defined by internal retroreflectors on the C-Mod midplane which return the beam to the second doubler and a detector array. This interferometer design has beam diameters of a few millimeters and element spacings of a few centimeters, uses a repetitively pulsed, TEM 00 Nd:YAG laser, fiber optic beam transport, commercial components, and a compact optical design which minimizes port space requirements. An optical system design is presented which is based on the performance of a tabletop prototype at Princeton Plasma Physics Laboratory. copyright 1997 American Institute of Physics

  2. Self-organized 3D equilibrium formation and its feedback control in RFX-mod

    International Nuclear Information System (INIS)

    Piovesan, P.; Bonfiglio, D.; Marrelli, L.; Soppelsa, A.; Spolaore, M.; Terranova, D.

    2014-01-01

    The reversed-field pinch exhibits a strong tendency to self-organize into a helical equilibrium as the plasma current is increased. The helical reversed-field pinch is characterized by reduced magnetic stochasticity and by the formation of electron internal transport barriers. The paper gives an update on recent experimental and modelling work on helical states in RFX-mod (Sonato et al 2003 Fusion Eng. Des. 66 161), also discussing similarities with 3D equilibria in tokamaks. The helical equilibrium is modelled with 3D codes developed for stellarators, such as VMEC/V3FIT. The reconstructed safety factor profile has low or reversed magnetic shear in the core, which may be related to transport barrier formation. A significant extension of the RFX-mod database to high current and density confirms the dependence observed before of various helical state properties on macroscopic quantities. Even under conditions where it does not form spontaneously, such as at low current or high density, the 3D magnetic equilibrium can be stimulated and robustly controlled with external fields applied by an extensive set of non axi-symmetric coils. An advanced magnetic feedback algorithm that compensates for error fields induced by eddy currents in the 3D wall structures has been developed. This work stimulated similar experiments in RFX-mod run as a tokamak, where external 3D fields are applied to control a m = 1/n = 1 helical equilibrium. (paper)

  3. RELAP5/MOD 3.3 analysis of Reactor Coolant Pump Trip event at NPP Krsko

    International Nuclear Information System (INIS)

    Bencik, V.; Debrecin, N.; Foretic, D.

    2003-01-01

    In the paper the results of the RELAP5/MOD 3.3 analysis of the Reactor Coolant Pump (RCP) Trip event at NPP Krsko are presented. The event was initiated by an operator action aimed to prevent the RCP 2 bearing damage. The action consisted of a power reduction, that lasted for 50 minutes, followed by a reactor and a subsequent RCP 2 trip when the reactor power was reduced to 28 %. Two minutes after reactor trip, the Main Steam Isolation Valves (MSIV) were isolated and the steam dump flow was closed. On the secondary side the Steam Generator (SG) pressure rose until SG 1 Safety Valve (SV) 1 opened. The realistic RELAP5/MOD 3.3 analysis has been performed in order to model the particular plant behavior caused by operator actions. The comparison of the RELAP5/MOD 3.3 results with the measurement for the power reduction transient has shown small differences for the major parameters (nuclear power, average temperature, secondary pressure). The main trends and physical phenomena following the RCP Trip event were well reproduced in the analysis. The parameters that have the major influence on transient results have been identified. In the paper the influence of SG 1 relief and SV valves on transient results was investigated more closely. (author)

  4. Long Term Retention of Deuterium and Tritium in Alcator C-Mod

    International Nuclear Information System (INIS)

    FIORE, C.; LABOMBARD, B.; LIPSCHULTZ, B.; PITCHER, C.S.; SKINNER, C.H.; WAMPLER, WILLIAM R.

    1999-01-01

    We estimate the total in-vessel deuterium retention in Alcator C-Mod from a run campaign of about 1090 plasmas. The estimate is based on measurements of deuterium retained on 22 molybdenum tiles from the inner wall and divertor. The areal density of deuterium on the tiles was measured by nuclear reaction analysis. From these data, the in-vessel deuterium inventory is estimated to be about 0.1 gram, assuming the deuterium coverage is toroidally symmetric. Most of the retained deuterium is on the walls of the main plasma chamber, only about 2.5% of the deuterium is in the divertor. The D coverage is consistent with a layer saturated by implantation with ions and charge-exchange neutrals from the plasma. This contrasts with tokamaks with carbon plasma-facing components (PFC's) where long-term retention of tritium and deuterium is large and mainly in the divertor due to codeposition with carbon eroded by the plasma. The low deuterium retention in the C-Mod divertor is mainly due to the absence of carbon PFC's in C-Mod and the low erosion rate of Mo

  5. Radiorespirometic assay device

    International Nuclear Information System (INIS)

    Levin, G.V.; Straat, P.A.

    1981-01-01

    A radiorespirometic assay device is described in which the presence of microorganisms in a sample is determined by placing the sample in contact with a metabolisable radioactive labelled substrate, collecting any gas evolved, exposing a photosensitive material to the gas and determining if a spot is produced on the material. A spot indicates the presence of radioactivity showing that the substrate has been metabolized by a microorganism. Bacteria may be detected in body fluids, hospital operating rooms, water, food, cosmetics and drugs. (U.K.)

  6. Radon assay for SNO+

    Energy Technology Data Exchange (ETDEWEB)

    Rumleskie, Janet [Laurentian University, Greater Sudbury, Ontario (Canada)

    2015-12-31

    The SNO+ experiment will study neutrinos while located 6,800 feet below the surface of the earth at SNOLAB. Though shielded from surface backgrounds, emanation of radon radioisotopes from the surrounding rock leads to back-grounds. The characteristic decay of radon and its daughters allows for an alpha detection technique to count the amount of Rn-222 atoms collected. Traps can collect Rn-222 from various positions and materials, including an assay skid that will collect Rn-222 from the organic liquid scintillator used to detect interactions within SNO+.

  7. Les industries culturelles en mutation : des modèles en question

    Directory of Open Access Journals (Sweden)

    Lucien Perticoz

    2012-09-01

    Full Text Available La présente contribution se propose de questionner la notion de modèles socio-économiques dans le cadre des travaux relatifs aux mutations des industries culturelles. À cette fin, l’exposé se déroulera en trois temps : nous reviendrons tout d’abord sur les caractéristiques essentielles des modèles génériques (modèle éditorial et de flot ainsi que sur leurs principaux apports ; nous expliquerons ensuite dans quelle mesure ils doivent être considérés, non comme une description fidèle de la réalité dont ils entendent rendre compte, mais davantage comme des règles du jeu permettant d’appréhender les mutations à l’œuvre ; enfin, à l’aune de la numérisation des contenus et de leur consommation via Internet, nous interrogerons l’hypothèse de l’émergence de nouveaux modèles génériques. En conclusion, nous insisterons sur la nécessité, à notre sens, de prendre en compte l’évolution des pratiques culturelles médiatiques en tant que dimension structurante de ces modèles.This paper aims to question the concept of socio-economic models within the framework of research about cultural industries mutations. For this purpose, our presentation will proceed in three parts : first of all, we will reconsider the essential characteristics of the generic models (publishing model and flow model and their main contributions to the research ; we will explain then why they must be considered, not as a faithful description of the reality of which they intend to give an account, but more like rules of the game allowing to understand the mutations of cultural industries ; finally, considering the digitalization of contents and their consumption using Internet, we will question the hypothesis of the emergence of new generic models. In conclusion, we will insist on the importance, from our opinion, to take into account the evolution of the media cultural practices as a structuring dimension of these models.

  8. From the Last Interglacial to the Anthropocene: Modelling a Complete Glacial Cycle (PalMod)

    Science.gov (United States)

    Brücher, Tim; Latif, Mojib

    2017-04-01

    We will give a short overview and update on the current status of the national climate modelling initiative PalMod (Paleo Modelling, www.palmod.de). PalMod focuses on the understanding of the climate system dynamics and its variability during the last glacial cycle. The initiative is funded by the German Federal Ministry of Education and Research (BMBF) and its specific topics are: (i) to identify and quantify the relative contributions of the fundamental processes which determined the Earth's climate trajectory and variability during the last glacial cycle, (ii) to simulate with comprehensive Earth System Models (ESMs) the climate from the peak of the last interglacial - the Eemian warm period - up to the present, including the changes in the spectrum of variability, and (iii) to assess possible future climate trajectories beyond this century during the next millennia with sophisticated ESMs tested in such a way. The research is intended to be conducted over a period of 10 years, but with shorter funding cycles. PalMod kicked off in February 2016. The first phase focuses on the last deglaciation (app. the last 23.000 years). From the ESM perspective PalMod pushes forward model development by coupling ESM with dynamical ice sheet models. Computer scientists work on speeding up climate models using different concepts (like parallelisation in time) and one working group is dedicated to perform a comprehensive data synthesis to validate model performance. The envisioned approach is innovative in three respects. First, the consortium aims at simulating a full glacial cycle in transient mode and with comprehensive ESMs which allow full interactions between the physical and biogeochemical components of the Earth system, including ice sheets. Second, we shall address climate variability during the last glacial cycle on a large range of time scales, from interannual to multi-millennial, and attempt to quantify the relative contributions of external forcing and processes

  9. RAS - Screens & Assays - Drug Discovery

    Science.gov (United States)

    The RAS Drug Discovery group aims to develop assays that will reveal aspects of RAS biology upon which cancer cells depend. Successful assay formats are made available for high-throughput screening programs to yield potentially effective drug compounds.

  10. Phosphorylcholine impairs susceptibility to biofilm formation of hydrogel contact lenses.

    Science.gov (United States)

    Selan, Laura; Palma, Stefano; Scoarughi, Gian Luca; Papa, Rosanna; Veeh, Richard; Di Clemente, Daniele; Artini, Marco

    2009-01-01

    To compare silicone-hydrogel, poly(2-hydroxyethyl methacrylate) (pHEMA), and phosphorylcholine-coated (PC-C) contact lenses in terms of their susceptibility to biofilm formation by Staphylococcus epidermidis and Pseudomonas aeruginosa. Laboratory investigation. Biofilm formation on colonized test lenses was evaluated with confocal microscopy and in vitro antibiotic susceptibility assays. The results of the latter assays were compared with those performed on planktonic cultures of the same organism. For both microorganisms, sessile colonies on silicone-hydrogel and pHEMA lenses displayed lower antibiotic susceptibility than their planktonic counterparts. In contrast, the susceptibility of cultures growing on PC-C lenses was comparable with that for planktonic cultures. In particular, minimum inhibitory concentration for Tazocin (piperacillin plus tazobactam; Wyeth Pharmaceuticals, Aprilia, Italy; S. epidermidis) and gentamicin (P. aeruginosa) was identical, either in the presence of PC-C support or in planktonic cultures (Tazocin, aeruginosa) was two-fold higher for PC-C lenses (0.4 mug/ml) with respect to planktonic cultures (0.2 mug/ml). Confocal microscopy of lenses colonized for 24 hours with P. aeruginosa green fluorescent protein-expressing cells revealed a sessile colonization on silicone-hydrogel lens and a few isolated bacterial cells scattered widely over the surface of the PC-C lens. An increase in antibiotic susceptibility of bacterial cultures was associated with diminished bacterial adhesion. Our results indicate that PC-C lenses seem to be more resistant than silicone-hydrogel and pHEMA lenses to bacterial adhesion and colonization. This feature may facilitate their disinfection.

  11. Improving shuffler assay accuracy

    International Nuclear Information System (INIS)

    Rinard, P.M.

    1995-01-01

    Drums of uranium waste should be disposed of in an economical and environmentally sound manner. The most accurate possible assays of the uranium masses in the drums are required for proper disposal. The accuracies of assays from a shuffler are affected by the type of matrix material in the drums. Non-hydrogenous matrices have little effect on neutron transport and accuracies are very good. If self-shielding is known to be a minor problem, good accuracies are also obtained with hydrogenous matrices when a polyethylene sleeve is placed around the drums. But for those cases where self-shielding may be a problem, matrices are hydrogenous, and uranium distributions are non-uniform throughout the drums, the accuracies are degraded. They can be greatly improved by determining the distributions of the uranium and then applying correction factors based on the distributions. This paper describes a technique for determining uranium distributions by using the neutron count rates in detector banks around the waste drum and solving a set of overdetermined linear equations. Other approaches were studied to determine the distributions and are described briefly. Implementation of this correction is anticipated on an existing shuffler next year

  12. Competitive protein binding assay

    International Nuclear Information System (INIS)

    Kaneko, Toshio; Oka, Hiroshi

    1975-01-01

    The measurement of cyclic GMP (cGMP) by competitive protein binding assay was described and discussed. The principle of binding assay was represented briefly. Procedures of our method by binding protein consisted of preparation of cGMP binding protein, selection of 3 H-cyclic GMP on market, and measurement procedures. In our method, binding protein was isolated from the chrysalis of silk worm. This method was discussed from the points of incubation medium, specificity of binding protein, the separation of bound cGMP from free cGMP, and treatment of tissue from which cGMP was extracted. cGMP existing in the tissue was only one tenth or one scores of cGMP, and in addition, cGMP competed with cGMP in binding with binding protein. Therefore, Murad's technique was applied to the isolation of cGMP. This method provided the measurement with sufficient accuracy; the contamination by cAMP was within several per cent. (Kanao, N.)

  13. Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis.

    LENUS (Irish Health Repository)

    Schulz, Bettina

    2012-05-01

    The effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the presence of DOX in the chequerboard assay with FIC indices suggesting an antagonistic effect. Gene expression analyses showed an overexpression of CdCDR2. Hence, DOX was found to have an impact on resistance mechanisms in C. dubliniensis isolates.

  14. Multiple drug-susceptibility screening in Mycobacterium bovis: new nucleotide polymorphisms in the embB gene among ethambutol susceptible strains

    Directory of Open Access Journals (Sweden)

    Cinzia Marianelli

    2015-04-01

    Conclusion: All M. bovis isolates were sensitive to the most common antituberculosis drugs used for treatment. There was a good agreement between the d-REMA assay and the agar based reference method. Among ethambutol susceptible isolates, four new embB mutations were found.

  15. Aircraft Survivability. Susceptibility Reduction. Fall 2010

    Science.gov (United States)

    2010-01-01

    the angle and velocity of impact based on wind tunnel testing and ModSim. Test results will provide better insight into the consequences of a...http://www.ndia.org/meetings/1910/Pages/ default.aspx JASP Spring PMSG 29–31 March 2011 TBD

  16. Comparative susceptibility of veliger larvae of four bivalve mollusks to a Vibrio alginolyticus strain.

    Science.gov (United States)

    Luna-González, A; Maeda-Martínez, A N; Sainz, J C; Ascencio-Valle, F

    2002-06-03

    The susceptibility of 7 d old veliger larvae of the scallops Argopecten ventricosus and Nodipecten subnodosus, the penshell Atrina maura, and the Pacific oyster Crassostrea gigas to a pathogenic strain of Vibrio alginolyticus was investigated by challenging the larvae with different bacterial concentrations in a semi-static assay. The results indicate that the larvae of the 2 scallop species are more susceptible to the V. alginolyticus strain than those of the oyster and the penshell. Signs of the disease were similar to bacillary necrosis described in previous work. Interspecies differences in susceptibility to pathogens are discussed.

  17. Susceptibility Genes in Thyroid Autoimmunity

    Directory of Open Access Journals (Sweden)

    Yoshiyuki Ban

    2005-01-01

    Full Text Available The autoimmune thyroid diseases (AITD are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g. dietary iodine is believed to initiate the autoimmune response to thyroid antigens. Abundant epidemiological data, including family and twin studies, point to a strong genetic influence on the development of AITD. Various techniques have been employed to identify the genes contributing to the etiology of AITD, including candidate gene analysis and whole genome screening. These studies have enabled the identification of several loci (genetic regions that are linked with AITD, and in some of these loci, putative AITD susceptibility genes have been identified. Some of these genes/loci are unique to Graves' disease (GD and Hashimoto's thyroiditis (HT and some are common to both the diseases, indicating that there is a shared genetic susceptibility to GD and HT. The putative GD and HT susceptibility genes include both immune modifying genes (e.g. HLA, CTLA-4 and thyroid specific genes (e.g. TSHR, Tg. Most likely, these loci interact and their interactions may influence disease phenotype and severity.

  18. Resistance of solanum species to phytophthora infestans evaluated in the detached-leaf and whole-plant assays

    International Nuclear Information System (INIS)

    Akhtar, K.P.; Saleem, M.Y.; Asghar, M.

    2012-01-01

    The reaction of 82 tomato genotypes belonging to 8 Solanum and a Lycopersicon species against Phytophthora infestans causing late blight was determined using detached-leaf and whole-plant assays. None of the test genotypes was immune or highly resistant. Of the 82 commercial and wild genotypes only TMS-2 (male-sterile and characterized by indeterminate growth) belonging to Lycopersicon esculentum was resistant with severity index of 2.4 in the detached-leaf assay on 0-5 scale (where 5 was highly susceptible) and percent disease index (%DI) of 23.3% under the whole-plant assay. Among the remaining genotypes, 41 were susceptible and 40 were highly susceptible under the detached-leaf assay, while 18 were susceptible and 63 were highly susceptible under the whole-plant assay. However, there was a significant difference in %DI for genotypes under the whole-plant assay. The response of whole-plants to inoculation with P. infestans in the detached-leaf assay was similar in all cases. The overall screening results indicate that TMS-2 is a good source of resistance and it can be useful for the development of tomato hybrid cultivars resistant to late blight. (author)

  19. Standardissimo. Les limitations théoriques du Modèle Standard. Quelles réponses y apporter?

    Science.gov (United States)

    Renard, F. M.

    Nous présentons I 'état du Modèle Standard des interactions fortes, faibles et électromagnétiques. Après une description rapide de ses 3 secteurs, secteur de jauge (radiation), secteur fermionique (matière) et secteur scalaire (génération des masses), nous insistons sur le grand nombre de paramètres libres et sur les choix arbitraires qu'il a fallu faire dans l'élaboration du modèle. Nous faisons ressortir les problèmes techniques non résolus et nous dressons la liste des questions fondamentales restées sans réponses. Nous passons ensuite en revue les idées et méthodes proposées pour répondre à ces questions. Elles utilisent essentiellement 3 voies différentes. La première consiste à requérir plus de symétrie (extension du modèle, symétrie Gauche-Droite, Grandes Unifications, Supersymétrie,...). La seconde contient les diverses alternatives au Modèle Standard impliquant des modifications dans certains secteurs (par exemple le secteur scalaire avec le modèle de la Technicouleur) ou de façon plus violente l'hypothèse d'une sous-structure des leptons, des quarks et des bosons W et Z eux-mêmes. Une dernière voie cherche à justifier les particularités du Modèle Standard et relier ses paramètres libres en se basant sur des principes de cohérence interne du modèle. Les conséquences observables de ces diverses approches sont dans chaque cas mentionnées.

  20. An acoustic prion assay

    Directory of Open Access Journals (Sweden)

    Gordon Hayward

    2016-12-01

    Full Text Available An acoustic prion assay has been demonstrated for sheep brain samples. Only five false positives and no false negatives were observed in a test of 45 positive and 45 negative samples. The acoustic prion sensor was constructed using a thickness shear mode quartz resonator coated with a covalently bound recombinant prion protein. The characteristic indicator of a scrapie infected sheep brain sample was an observed shoulder in the frequency decrease in response to a sample.The response of the sensor aligns with a conformational shift in the surface protein and with the propagation mechanism of the disease. This alignment is evident in the response timing and shape, dependence on concentration, cross species behaviour and impact of blood plasma. This alignment is far from sufficient to prove the mechanism of the sensor but it does offer the possibility of a rapid and inexpensive additional tool to explore prion disease. Keywords: Prions, Thickness shear mode quartz sensor

  1. Assay of oestrogen

    International Nuclear Information System (INIS)

    Edwards, J.C.

    1981-01-01

    A particular problem with the direct radioimmunoassay of unconjugated oestriol in pregnancy is caused by the increased amount of steroid-binding proteins present in pregnancy serum and plasma. The steroid-binding proteins react with oestriol and 125 I-labelled oestriol during the assay procedure and the steroid-protein bound 125 I-labelled oestriol is precipitated along with the antibody-bound 125 I-labelled oestriol by the ammonium sulphate solution separation system. A novel method is described whereby progesterone (1-20 μg/ml) is used to block the action of steroid-binding proteins in pregnancy serum and plasma samples, thus minimizing interference in a direct radioimmunoassay for unconjugated oestriol using a specific anti-oestriol serum. (U.K.)

  2. Cerebral malaria: susceptibility weighted MRI

    Directory of Open Access Journals (Sweden)

    Vinit Baliyan

    2015-03-01

    Full Text Available Cerebral malaria is one of the fatal complications of Plasmodium falciparum infection. Pathogenesis involves cerebral microangiopathy related to microvascular plugging by infected red blood cells. Conventional imaging with MRI and CT do not reveal anything specific in case of cerebral malaria. Susceptibility weighted imaging, a recent advance in the MRI, is very sensitive to microbleeds related to microangiopathy. Histopathological studies in cerebral malaria have revealed microbleeds in brain parenchyma secondary to microangiopathy. Susceptibility weighted imaging, being exquisitely sensitive to microbleeds may provide additional information and improve the diagnostic accuracy of MRI in cerebral malaria.

  3. Topological susceptibility from the overlap

    DEFF Research Database (Denmark)

    Del Debbio, Luigi; Pica, Claudio

    2003-01-01

    The chiral symmetry at finite lattice spacing of Ginsparg-Wilson fermionic actions constrains the renormalization of the lattice operators; in particular, the topological susceptibility does not require any renormalization, when using a fermionic estimator to define the topological charge....... Therefore, the overlap formalism appears as an appealing candidate to study the continuum limit of the topological susceptibility while keeping the systematic errors under theoretical control. We present results for the SU(3) pure gauge theory using the index of the overlap Dirac operator to study...

  4. Effect of feeding broilers diets differing in susceptible phytate content

    Directory of Open Access Journals (Sweden)

    Natalie K. Morgan

    2016-03-01

    Full Text Available Measurements of total phytate phosphorus content of diets may be deceptive as they do not indicate substrate availability for phytase; it may be that measurements of phytate susceptible to phytase effects are a more accurate measure of phosphorus (P availability to the bird. To verify this hypothesis, an experiment was conducted to compare diets formulated to contain either high or low susceptible phytate, supplemented with either 0 or 500 FTU/kg phytase. Susceptible phytate was determined by exposing the feed samples to conditions that mimicked the average pH of the proximal gastrointestinal tract (pH 4.5 and the optimum temperature for phytase activity (37 °C and then measuring phytate dissolved. Ross 308 birds (n = 240 were fed one of 4 dietary treatments in a 2 × 2 factorial design; 2 diets with high (8.54 g/kg, 57.90% of total phytate or low (5.77 g/kg, 46.33% of total phytate susceptible phytate, containing 0 or 500 FTU/kg phytase. Diets were fed to broilers (12 replicate pens of 5 birds per pen from d 0 to 28 post hatch. Birds fed diets high in susceptible phytate had greater phytate hydrolysis in the gizzard (P < 0.001, jejunum (P < 0.001 and ileum (P < 0.001 and resulting greater body weight gain (BWG (P = 0.015 and lower FCR (P = 0.003 than birds fed the low susceptible phytate diets, irrespective of phytase presence. Birds fed the high susceptible diets also had greater P solubility in the gizzard and Ca and P solubility in the jejunum and ileum (P < 0.05 and resulting greater tibia and femur Ca and P (P < 0.05 content than those fed the low susceptible diets. All the susceptible phytate was fully degraded in the tract in the absence of added phytase, suggesting the assay used in this study was able to successfully estimate the amount of total dietary phytate that was susceptible to the effects of phytase when used at standard levels. No interactions were observed between susceptible phytate and phytase on

  5. Implementation of PWR steady state self-initialization feature into RELAP4/MOD6/U4/J3

    International Nuclear Information System (INIS)

    Yoshida, Kazuo

    1987-07-01

    A PWR steady state self-initialization feature has been implemented into the RELAP4/MOD6/U4/J3 code which is an improved version of RELAP4/MOD6 and can analyze not only large break but also small break LOCA in LWRs. This feature is originated from RELAP4/MOD7 which is the most updated released version of RELAP4 from INEL. Several FORTRAN subroutines in MOD7 related to this feature were transplanted into MOD6/U4/J3 with some improvements, which were the modification of method to take a balance of heat transfer between primary and secondary side at SG-U tubes, and to make it possible to nodalize secondary side of SG as multi-node. Advantages realized by implementation of this option are saving of time in initializaing a new model and an assurance of steady state and self consistency of input data in a small break LOCA analysis of a PWR. (author)

  6. Improving containment mass and energy releases for CONTEMPT-LT/028 TU with RELAP5/MOD3

    International Nuclear Information System (INIS)

    DaSilva, H.C.; Choe, W.G.

    1996-01-01

    In order to obtain boundary conditions for RELAP5/MOD3 best estimate (BE) large break (LB) loss-of-coolant accident (LOCA) calculations, it is necessary to utilize a separate containment analysis code CONTEMPT-LT/028 TU, which in turn accepts mass and energy releases from the RELAP5/MOD3 calculation. When these boundary conditions are obtained, they are observed to be significantly lower than those reported in FSAR containment analyses. This motivates the present study, where RELAP5/MOD3 mass and energy releases are generated using the same assumptions listed in the FSAR containment calculations. Then CONTEMPT-LT/028 TU pressures and temperatures calculated with both sets of mass and energy releases are compared. It is seen that those obtained with the RELAP5/MOD3 input are still significantly lower, indicating a level of conservatism in the FSAR mass and energy releases that is even above that explicitly listed and also incorporated into the RELAP5/MOD3 calculation. An important conclusion from this finding is that Environmental Qualification (EQ) issues requiring containment re-analyses are likely to be easily resolved if new mass and energy releases are calculated with state-of-the-art LOCA codes modeling the entire reactor coolant system, even when conservative assumptions are incorporated

  7. Relap5/mod2 post-test calculation of a loss of feedwater experiment at the Pactel test facility

    Energy Technology Data Exchange (ETDEWEB)

    Protze, M. [Siemens-KWU, Erlangen (Germany)

    1995-12-31

    Post-test calculations for verification purposes of the thermal hydraulic code RELAP5/MOD2 are of fundamental importance for the licensing procedure. The RELAP5/MOD2 code has a large international assessment base regarding western PWR. WWER-reactors are russian designed PWRs with some specific differences compared with the western PWR`s, especially the horizontal steam generators. For that reason some post-test calculations have to be performed to verify the RELAP5/MOD2 code for these WWER typical phenomena. The impact of the horizontal steam generators on the accident behaviour during transients or pipe ruptures on the secondary side is significant. The nodalization of the test facility PACTEL was chosen equally to WWER plant nodalization to verify the use of a coarse modelling of the steam generator secondary side for analyses of transient with decreasing water level in the SG secondary side. The calculational results showed a good compliance to the test results, demonstrating the correct use of a coarse nodalization. To sum up, the RELAP5/ MOD2 results met the test results appropriately thereby the RELAP5/ MOD2 code is validated for analyses of transients with decreasing water level in a horizontal steam generator secondary side. (orig.). 4 refs.

  8. Relap5/mod2 post-test calculation of a loss of feedwater experiment at the Pactel test facility

    Energy Technology Data Exchange (ETDEWEB)

    Protze, M [Siemens-KWU, Erlangen (Germany)

    1996-12-31

    Post-test calculations for verification purposes of the thermal hydraulic code RELAP5/MOD2 are of fundamental importance for the licensing procedure. The RELAP5/MOD2 code has a large international assessment base regarding western PWR. WWER-reactors are russian designed PWRs with some specific differences compared with the western PWR`s, especially the horizontal steam generators. For that reason some post-test calculations have to be performed to verify the RELAP5/MOD2 code for these WWER typical phenomena. The impact of the horizontal steam generators on the accident behaviour during transients or pipe ruptures on the secondary side is significant. The nodalization of the test facility PACTEL was chosen equally to WWER plant nodalization to verify the use of a coarse modelling of the steam generator secondary side for analyses of transient with decreasing water level in the SG secondary side. The calculational results showed a good compliance to the test results, demonstrating the correct use of a coarse nodalization. To sum up, the RELAP5/ MOD2 results met the test results appropriately thereby the RELAP5/ MOD2 code is validated for analyses of transients with decreasing water level in a horizontal steam generator secondary side. (orig.). 4 refs.

  9. ModSAF-based development of operational requirements for light armored vehicles

    Science.gov (United States)

    Rapanotti, John; Palmarini, Marc

    2003-09-01

    Light Armoured Vehicles (LAVs) are being developed to meet the modern requirements of rapid deployment and operations other than war. To achieve these requirements, passive armour is minimized and survivability depends more on sensors, computers, countermeasures and communications to detect and avoid threats. The performance, reliability, and ultimately the cost of these systems, will be determined by the technology trends and the rates at which they mature. Defining vehicle requirements will depend upon an accurate assessment of these trends over a longer term than was previously needed. Modelling and simulation are being developed to study these long-term trends and how they contribute to establishing vehicle requirements. ModSAF is being developed for research and development, in addition to the original requirement of Simulation and Modelling for Acquisition, Rehearsal, Requirements and Training (SMARRT), and is becoming useful as a means for transferring technology to other users, researchers and contractors. This procedure eliminates the need to construct ad hoc models and databases. The integration of various technologies into a Defensive Aids Suite (DAS) can be designed and analyzed by combining field trials and laboratory data with modelling and simulation. ModSAF (Modular Semi-Automated Forces,) is used to construct the virtual battlefield and, through scripted input files, a "fixed battle" approach is used to define and implement contributions from three different sources. These contributions include: models of technology and natural phenomena from scientists and engineers, tactics and doctrine from the military and detailed analyses from operations research. This approach ensures the modelling of processes known to be important regardless of the level of information available about the system. Survivability of DAS-equipped vehicles based on future and foreign technology can be investigated by ModSAF and assessed relative to a test vehicle. A vehicle can

  10. Flux pinning characteristics of Sn-doped YBCO film by the MOD process

    International Nuclear Information System (INIS)

    Choi, S.M.; Shin, G.M.; Yoo, S.I.

    2013-01-01

    Highlights: ► The pinning effects of undoped and Sn-doped YBCO films by MOD were characterized. ► Sn-containing nanoparticles were trapped in Sn-doped YBCO films by MOD. ► Sn-containing nanoparticles were identified as the YBa 2 SnO 5.5 (YBSO) phase by TEM. ► The YBSO nanoparticles are responsible for improved flux pinning effect. ► We report the orientation relationship between YBSO nanoparticles and YBCO matrix. -- Abstract: Compared with the undoped YBa 2 Cu 3 O 7−δ (YBCO) film, 10 mol% Sn-doped YBCO film exhibited significantly enhanced critical current densities (J c ) in magnetic fields up to 5 T at 65 and 77 K for H//c, indicating that the Sn-doped YBCO film possesses more effective flux pinning centers. Both samples were grown on the SrTiO 3 (STO) (1 0 0) single crystal substrates by the metal-organic deposition (MOD) process. Larger J c (77 K, 1 T) values of Sn-doped YBCO film are observed over a wide field-orientation angle (θ) except the field-orientations close to the ab-plane of YBCO (85° c values for 85° 2 SnO 5.5 (YBSO) phase by STEM (scanning transmission electron microscopy)-EDS (energy dispersive X-ray spectroscopy) analysis. Further analyses by HR-TEM (high resolution-transmission electron microscopy) revealed that YBSO nanoparticles completely surrounded by the YBCO matrix had random orientation with YBCO while those located at the interface of YBCO/STO substrate had epitaxial relationship with YBCO

  11. Study of the Relap5/mod3.2 wall heat flux partitioning model

    International Nuclear Information System (INIS)

    Hari, S.; Hassan, Y.A.

    2001-01-01

    The performance of the subcooled boiling model adapted in RELAP5/MOD3.2 computer code has been assessed in detail for low-pressure conditions and it has been found that the void fraction profile is under-predicted. In general, any subcooled boiling model is composed of individual sub-models that account for the different physical mechanism that govern the overall process, as the wall vapor generation, interfacial shear and condensation etc. The wall heat flux partitioning model is one of the important sub-models that is a constituent of any subcooled boiling model. The function of this model is to apportion the wall heat flux to the different components (as the single/two phase fluid or bubble), as the case may be, in a two-phase flow-boiling scenario adjacent to a heated wall. The ''pumping factor'' approach is generally followed by most of the wall heat flux partitioning models, for partitioning the wall heat flux. In this work, the wall heat flux partitioning model of RELAP5/MOD3.2 computer code is studied; in particular, the ''pumping factor'' formulation in the present code version is assessed for its performance under low-pressure conditions. In addition, three different ''pumping factor'' formulations available in the literature have been introduced into the RELAP5/MOD3.2 code. Simulations of two low-pressure subcooled flow boiling experiments were performed with the refined code versions to determine the appropriate pumping factor to be used under these conditions. (author)

  12. Evaluation of fuel-temperature feedback mechanisms in TRAC-PF1/MOD2/NESTLE

    International Nuclear Information System (INIS)

    Knepper, Paula L.; Feltus, Madeline; Hochreiter, L.E.; Ivanov, Kostadin

    1999-01-01

    Coupled spatial kinetics and thermal-hydraulics system codes provide a means to model transient nuclear reactor behavior more accurately. Transients marked by strong perturbations, both with thermal-hydraulics and neutronics, such as a control-rod ejection or a main steam-line break, are especially of interest. It is now feasible to model complex reactor behavior with a coupled thermal-hydraulics and spatial kinetics code that provides a means to forecast safety margins. Recently, the Transient Reactor Analysis Code (TRAC)-PF1/MOD2, Version 5.4.25, was coupled with the NESTLE code. This coupled code (TRAC-PF1/MOD2/NESTLE) is used to examine effective fuel-temperature models. The Electric Power Research Institute (EPRI) rod-ejection benchmark was analyzed to evaluate the influence of effective fuel temperature. The rod-ejection transient tests only the fuel-rod, heat-conduction coupling. The coolant thermal-hydraulic coupling is not tested because of the speed of the transient. The neutronics solution changes extremely rapidly, whereas the convective heat transfer at the fuel surface requires more time to influence the coolant temperature of the system. The need to model the response of the system coolant temperature is not crucial in this analysis. The influence of the effective fuel temperature is the key component of this study. Various models were examined using the coupled code to calculate effective fuel temperatures. The influence of different, effective fuel-temperature models on the coupled-code results is studied. Three effective fuel-temperature models are examined: (l) volume average effective fuel temperature, (2) the effective fuel-temperature model suggested by the Office of Economic Cooperation and Development (OECD) rod-ejection benchmark, and (3) the NESTLE effective fuel-temperature model. A discussion is provided describing the effective fuel-temperature models examined in TRAC-PF1/MOD2/NESTLE and the influence of effective fuel temperature in

  13. Production of internal transport barriers via self-generated mean flows in Alcator C-Mod

    Energy Technology Data Exchange (ETDEWEB)

    Fiore, C. L.; Ernst, D. R.; Podpaly, Y. A.; Howard, N. T.; Lee, Jungpyo; Reinke, M. L.; Rice, J. E.; Hughes, J. W.; Ma, Y. [MIT-PSFC, 77 Mass. Ave., Cambridge, Massachusetts 02139 (United States); Mikkelsen, D. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, New Jersey 08543-0451 (United States); Rowan, W. L.; Bespamyatnov, I. [FRC, U of Texas at Austin, Austin, Texas 78712 (United States)

    2012-05-15

    New results suggest that changes observed in the intrinsic toroidal rotation influence the internal transport barrier (ITB) formation in the Alcator C-Mod tokamak [E. S. Marmar and Alcator C-Mod group, Fusion Sci. Technol. 51, 261 (2007)]. These arise when the resonance for ion cyclotron range of frequencies (ICRF) minority heating is positioned off-axis at or outside of the plasma half-radius. These ITBs form in a reactor relevant regime, without particle or momentum injection, with Ti Almost-Equal-To Te, and with monotonic q profiles (q{sub min} < 1). C-Mod H-mode plasmas exhibit strong intrinsic co-current rotation that increases with increasing stored energy without external drive. When the resonance position is moved off-axis, the rotation decreases in the center of the plasma resulting in a radial toroidal rotation profile with a central well which deepens and moves farther off-axis when the ICRF resonance location reaches the plasma half-radius. This profile results in strong E Multiplication-Sign B shear (>1.5 Multiplication-Sign 10{sup 5} rad/s) in the region where the ITB foot is observed. Gyrokinetic analyses indicate that this spontaneous shearing rate is comparable to the linear ion temperature gradient (ITG) growth rate at the ITB location and is sufficient to reduce the turbulent particle and energy transport. New and detailed measurement of the ion temperature demonstrates that the radial profile flattens as the ICRF resonance position moves off axis, decreasing the drive for the ITG the instability as well. These results are the first evidence that intrinsic rotation can affect confinement in ITB plasmas.

  14. Du teikei à l’AMAP, un modèle acculturé

    Directory of Open Access Journals (Sweden)

    Jean Lagane

    2011-05-01

    Full Text Available Cet article compare à travers deux ethnographies en France et au Japon le modèle français de l’AMAP – association de maintien de l’agriculture paysanne – au modèle dont il se réclame, le teikei, système japonais de partenariat agricole entre producteurs et consommateurs. Terrain en mutation permanente, le développement des formes de circuit court et leurs emprunts accentuent lors de la transposition la nécessité de coller le plus étroitement possible à la réalité du terrain, à son histoire sociétale, à ses traditions institutionnelles et culturelles, à ses crises, à ses dynamiques. L’analyse fait apparaître à travers les similitudes, dissemblances et adaptations de ce modèle d’emprunt, l’incidence et la complexité de la prise en compte de facteurs culturels.After two ethnological fieldworks completed in France and Japan, this article deals with the French system of Community Supported Agriculture - AMAP - and its Japanese inspiration counterpart, the Teikei system built upon local solidarity-based partnerships between farmers and members. Constantly evolving, the growing process of agriculture one-shot sale circuits and the way they are received in other cultures recalls the necessity to tune with the reality of these societies, their history, their institutional and cultural traditions as well as their crises and dynamics. The analysis emphasizes the complexity of the acculturation process related with points of convergence and discrepancy.

  15. Transport and confinement studies in the RFX-mod reversed-field pinch experiment

    International Nuclear Information System (INIS)

    Innocente, P.; Alfier, A.; Carraro, L.; Lorenzini, R.; Pasqualotto, R.; Terranova, D.

    2007-01-01

    In the modified RFX experiment (RFX-mod) external magnetic field coils and a close fitting thin conductive shell control radial magnetic fields. In the so-called virtual shell (VS) operation, radial field zeroing at the thin shell radius is stationary provided by the feedback-controlled coils. First experiments on RFX-mod proved the capability of the active scheme to steadily reduce the radial magnetic field. Furthermore it has been found that such edge magnetic field control extends its beneficial effects to the whole plasma. With respect to the old RFX, where magnetohydrodynamic modes amplitude was controlled by the use of a passive thick conductive shell, a stationary 2- to 3-fold reduction of the B r field amplitude in the core is obtained. The reduction of field fluctuations positively reflects on confinement. In fact, a strong reduction of the loop voltage is observed and correspondingly a 3-fold increase in pulse length is achieved by using the same poloidal flux swing. Temperature and particle measurements confirm the improved confinement properties of the VS operation. With a lower ohmic input power, higher electron temperature and lower particle influx are measured. Particle and heat transport have been studied by means of a 1D code. Local power balance was used to compute the heat conductivity profile: for the VS discharges a lower conductivity over a significant region of the plasma is found. The improved properties of RFX-mod VS operation provide a better confinement scaling in terms of plasma current. The results show that compared with the thick shell configuration, a significant confinement improvement can be obtained under stationary conditions by actively controlling the plasma magnetic boundary

  16. GalMod: the last frontier of Galaxy population synthesis models

    Science.gov (United States)

    Pasetto, Stefano; Kollmeier, Juna; Grebel, Eva K.; chiosi, cesare

    2018-01-01

    We present a novel Galaxy population synthesis model: GalMod (Pasetto et al. 2016, 2017a,b) is the only star-count model featuring an asymmetric bar/bulge as well as spiral arms as directly obtained by applying linear perturbative theory to self-consistent distribution function of the Galaxy stellar populations. Compared to previous literature models (e.g., Besancon, Trilegal), GalMod allows to generate full-sky mock catalogue, M31 surveys and provides a better match to observed Milky Way (MW) stellar fields.The model can generate synthetic mock catalogs of visible portions of the MW, external galaxies like M31, or N-body simulation initial conditions. At any given time, e.g., a chosen age of the Galaxy, the model contains a sum of discrete stellar populations, namely bulge/bar, disk, halo. The disk population is itself the sum of subpopulations: spiral arms, thin disk, thick disk, and gas component, while the halo is modeled as the sum of a stellar component, a hot coronal gas, and a dark matter component. The Galactic potential is computed from these subpopulations' density profiles and used to generate detailed kinematics by considering the first few moments of the Boltzmann collisionless equation for all the stellar subpopulations. The same density profiles are then used to define the observed color-magnitude diagrams within an input field of view from an arbitrary solar location. Several photometric systems have been included and made available on-line, e.g., SDSS, Gaia, 2MASS, HST WFC3, and others. Finally, we model the extinction with advanced ray tracing solutions.The model's web page (and tutorial) can be accessed at www.GalMod.org.

  17. Prion protein and scrapie susceptibility

    NARCIS (Netherlands)

    Smits, M.A.; Bossers, A.; Schreuder, B.E.C.

    1997-01-01

    This article presents briefly current views on the role of prion protein (PrP) in Transmissible Spongiform Encephalopathies or prion diseases and the effect of PrP polymoryhisms on the susceptibility to these diseases, with special emphasis on sheep scrapie. The PrP genotype of sheep apears to be a

  18. Antifungal susceptibilities of Cryptococcus neoformans.

    Science.gov (United States)

    Archibald, Lennox K; Tuohy, Marion J; Wilson, Deborah A; Nwanyanwu, Okey; Kazembe, Peter N; Tansuphasawadikul, Somsit; Eampokalap, Boonchuay; Chaovavanich, Achara; Reller, L Barth; Jarvis, William R; Hall, Gerri S; Procop, Gary W

    2004-01-01

    Susceptibility profiles of medically important fungi in less-developed countries remain uncharacterized. We measured the MICs of amphotericin B, 5-flucytosine, fluconazole, itraconazole, and ketoconazole for Cryptococcus neoformans clinical isolates from Thailand, Malawi, and the United States and found no evidence of resistance or MIC profile differences among the countries.

  19. India, Genomic diversity & Disease susceptibility

    Indian Academy of Sciences (India)

    Table of contents. India, Genomic diversity & Disease susceptibility · India, a paradise for Genetic Studies · Involved in earlier stages of Immune response protecting us from Diseases, Responsible for kidney and other transplant rejections Inherited from our parents · PowerPoint Presentation · Slide 5 · Slide 6 · Slide 7.

  20. TRAC-BDl/MOD1 post-dryout wall heat transfer

    International Nuclear Information System (INIS)

    Shumway, R.W.

    1984-01-01

    A comparison of TRAC-BWR heat transfer package with 766 data points is presented. On the average, TRAC-BWR provides a better prediction of the data compared to any single correlation although there is still a large scatter in TRAC-BWR prediction. Regarding any potential changes in the TRAC-BD1/MOD1 wall heat transfer package, it is concluded that no significant improvement in the film boiling area can be made until data with better measurements are obtained and analyzed. Specifically, data is needed which has a wide range of accurately measured void fractions. Heated tube data is also needed which addresses the countercurrent flow transition conditions

  1. Posttest TRAC-PD2/MOD1 predictions for FLECHT SEASET test 31504

    International Nuclear Information System (INIS)

    Booker, C.P.

    1982-01-01

    TRAC-PD2/MOD1 is a publicly released version of TRAC that is used primarily to analyze large-break loss-of-coolant accidents in pressurized-water reactors (PWRs). TRAC-PD2 can calculate, among other things, reflood phenomena. TRAC posttest predictions are compared with test 31504 reflood data from the Full-Length Emergency Core Heat Transfer (FLECHT) System Effects and Separate Effects Tests (SEASET) facility. A false top-down quench is predicted near the top of the core and the subcooling is underpredicted at the bottom of the core. However, the overall TRAC predictions are good, especially near the center of the core

  2. RELAP5/MOD2 blind calculation of GERDA small break test and data comparison

    International Nuclear Information System (INIS)

    Ogden, D.M.; Steiner, J.L.; Waterman, M.E.

    1985-01-01

    The Idaho National Engineering Laboratory (INEL), in support of the USNRC, has developed a RELAP5/MOD2 model of the GERDA facility to be used for analysis of the GERDA data, particularly relative to the phenomena of natural circulation and the boiler condenser mode of heat transfer. A blind calculation of GERDA Test 1605AA and a preliminary comparison with experimental data has been performed. The GERDA facility is a single loop integral facility with an electrically heated core. A general arrangement diagram of the facility is shown. The GERDA facility was designed for the performance of both separate effects and overall systems tests

  3. Development and assessment of a modified version of RELAP5/MOD3

    Energy Technology Data Exchange (ETDEWEB)

    Analytis, G.T. [Paul Scherrer Institute, Villigen (Switzerland)

    1995-09-01

    A summary of a number of modifications introduced in RELAP/MOD3 is presented. These include implementation of different heat transfer packages for different processes, modification of the low mass-flux Groeneveld CHF look-up table and of the dispersed flow interfacial area (and shear) as well as of the criterion for transition into and out from this regime, elimination of the under-relaxation schemes of the interfacial closure coefficients etc. The modified code is assessed against a number of separate-effect and integral test experiments and in contrast to the frozen version, is shown to result in physically sound predictions which are close to the measurements.

  4. ModFossa: A library for modeling ion channels using Python.

    Science.gov (United States)

    Ferneyhough, Gareth B; Thibealut, Corey M; Dascalu, Sergiu M; Harris, Frederick C

    2016-06-01

    The creation and simulation of ion channel models using continuous-time Markov processes is a powerful and well-used tool in the field of electrophysiology and ion channel research. While several software packages exist for the purpose of ion channel modeling, most are GUI based, and none are available as a Python library. In an attempt to provide an easy-to-use, yet powerful Markov model-based ion channel simulator, we have developed ModFossa, a Python library supporting easy model creation and stimulus definition, complete with a fast numerical solver, and attractive vector graphics plotting.

  5. Evaluation of void fraction measurements from DADINE experience using RELAP4/MOD5 code

    International Nuclear Information System (INIS)

    Borges, R.C.; Freitas, R.L.

    1989-01-01

    The DADINE experiment measures the axial evolution of the void fraction by neutronic diffusion in two-phase flow in the wet regions of a pressurized water reactor in accident conditions. Since the theoretical/experimental confrontation is important for code evaluation, this paper presents the simulation with the RELAP4/MOD5 Code of the void fractions results obtained in the DADINE Experiment, that showed some deviation probably associated with the existing models in Code, special attention in the way of stablishing the two-phase flow and the no characterization of the differents flow regimes related with the void fractions. (author) [pt

  6. Assessment of critical flow models of RELAP5-MOD2 and CATHARE codes

    International Nuclear Information System (INIS)

    Hao Laomi; Zhu Zhanchuan

    1992-01-01

    The critical flow tests for the long and short nozzles conducted on the SUPER MOBY-DICK facility were analyzed using the RELAP5-MOD2 and CATHARE 1.3 codes to assess the critical flow models of two codes. The critical mass flux calculated for two nozzles are given. The CATHARE code has used the thermodynamic nonequilibrium sound velocity of the two-phase fluid as the critical flow criterion, and has the better interphase transfer models and calculates the critical flow velocities with the completely implicit solution. Therefore, it can well calculate the critical flowrate and can describe the effect of the geometry L/D on the critical flowrate

  7. ”Giv vold mod kvinder det røde kort” - En kampagneanalyse

    OpenAIRE

    Dührr, Tine; Jeberg Kjær, Cecilie; Lassen Jørgensen, Katrine; Linea Pohl, Dina

    2013-01-01

    This project investigates if the campaign “Giv vold mod kvinder det røde kort” is successful in reaching its target audience. We keep a strict focus on the campaign’s Facebook page, because of its obvious role as the primary place where the target audience will encounter the campaign. We examine the Facebook page through a discourse analysis, to get a clear sense of the difficulties with reaching the target audience. Afterwards we examine the target audience, with a focus group interview to g...

  8. CORCON-MOD3: An integrated computer model for analysis of molten core-concrete interactions

    International Nuclear Information System (INIS)

    Bradley, D.R.; Gardner, D.R.; Brockmann, J.E.; Griffith, R.O.

    1993-10-01

    The CORCON-Mod3 computer code was developed to mechanistically model the important core-concrete interaction phenomena, including those phenomena relevant to the assessment of containment failure and radionuclide release. The code can be applied to a wide range of severe accident scenarios and reactor plants. The code represents the current state of the art for simulating core debris interactions with concrete. This document comprises the user's manual and gives a brief description of the models and the assumptions and limitations in the code. Also discussed are the input parameters and the code output. Two sample problems are also given

  9. Thermal-hydraulic analysis of the semiscale Mod-1 blowdown heat transfer test series

    International Nuclear Information System (INIS)

    Cozzuol, J.M.

    1976-06-01

    Selected experimental thermal-hydraulic data from the recent Semiscale Mod-1 blowdown heat transfer test series are analyzed from an experimental viewpoint with emphasis on explaining those phenomena which influence core fluid behavior. Comparisons are made between the trends measured by the system instrumentation and the trends predicted by the RELAP4 computer code to aid in obtaining an understanding of the interactions between phenomena occurring in different parts of the system. The analyses presented in this report are valuable for evaluating the adequacy and improving the predictive capability of analytical models developed to predict the system response of a pressurized water reactor during a postulated loss-of-coolant accident

  10. Framatome's experience in implementing and runnig RELAP5 MOD1

    Energy Technology Data Exchange (ETDEWEB)

    Truong, T.X.; Rousset, P.

    1984-12-01

    Implementation of RELAP MOD1 on Framatome's computer began in 1982, when we were working with the electrical power research institute on a safety and relief valve test program. It has been carried out in two stages: a first implementation on the CISI CYBER 740 computer; a transfer of files and a second on implemented our own CYBER 835 computer. The RELAP5 version currently implemented and used in Framatome is the cycle 19 standard version, no modification has been made yet, though some changes in data output files are intended.

  11. The ModFOLD4 server for the quality assessment of 3D protein models

    OpenAIRE

    McGuffin, Liam J.; Buenavista, Maria T.; Roche, Daniel B.

    2013-01-01

    Once you have generated a 3D model of a protein,\\ud how do you know whether it bears any resemblance\\ud to the actual structure? To determine the usefulness\\ud of 3D models of proteins, they must be assessed in\\ud terms of their quality by methods that predict their\\ud similarity to the native structure. The ModFOLD4\\ud server is the latest version of our leading independent\\ud server for the estimation of both the global and\\ud local (per-residue) quality of 3D protein models. The\\ud server ...

  12. Implementation of a nonequilibrium condensation model in RELAP4/MOD7

    International Nuclear Information System (INIS)

    Fischer, S.R.; Chow, H.; Van Arsdall, G.

    1979-01-01

    RALAp, which is used to simulate the thermal hydraulic behavior of light water reactors subjected to various LOCA transients, is based on the assumption of thermodynamic equilibrium between liquid and vapor within fluid volumes. This assumption, while being appropriate for much of a LOCA transient, is not adequate during the ECC accumulator injection phase as determined by comparisons of code calculations with experimental data. To overcome this limitation, a general model to simulate the nonequilibrium phenomena associated with the mixing of subcooled water with saturated steam has been developed and is operational on preliminary versions of RELAP4/MOD7

  13. neutron radiography. Report prepared from contributions by members of the MOD Working Party on Neutron Radiography

    International Nuclear Information System (INIS)

    Halmshaw, R.

    1977-03-01

    Radiography with thermal or cold neutrons has some special advantages over X-rays and gamma rays, and some facilities for neutron radiography exist in the Ministry of Defence. This report gives a brief and simple description of the technique, its advantages and disadvantages, and is illustrated with a number of Ordnance applications taken from MOD work, to show examples where neutron radiographs provided extra important information not available from X- or gamma radiography. The facilities available in the UK for neutron radiography are listed. (author)

  14. Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Lacko, Martin [Department of Otorhinolaryngology—Head and Neck Surgery, Maastricht University Medical Center, Maastricht (Netherlands); Braakhuis, Boudewijn J.M. [Department of Otolaryngology—Head and Neck Surgery, VU University Medical Center, Amsterdam (Netherlands); Sturgis, Erich M. [Department of Head and Neck Surgery and Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Boedeker, Carsten C. [Department of Otorhinolaryngology—Head and Neck Surgery, Albert-Ludwigs-University, Freiburg, Germany and Department of Otorhinolaryngology - Head and Neck Surgery, HELIOS Hanseklinikum Stralsund, Stralsund (Germany); Suárez, Carlos [Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo (Spain); Instituto Universitario de Oncología del Principado de Asturias, Oviedo (Spain); Rinaldo, Alessandra; Ferlito, Alfio [ENT Clinic, University of Udine, Udine (Italy); Takes, Robert P., E-mail: robert.takes@radboudumc.nl [Department of Otolaryngology—Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen (Netherlands)

    2014-05-01

    Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and its incidence is growing. Although environmental carcinogens and carcinogenic viruses are the main etiologic factors, genetic predisposition obviously plays a risk-modulating role, given that not all individuals exposed to these carcinogens experience the disease. This review highlights some aspects of genetic susceptibility to HNSCC: among others, genetic polymorphisms in biotransformation enzymes, DNA repair pathway, apoptotic pathway, human papillomavirus-related pathways, mitochondrial polymorphisms, and polymorphism related to the bilirubin-metabolized pathway. Furthermore, epigenetic variations, familial forms of HNSCC, functional assays for HNSCC risk assessment, and the implications and perspectives of research on genetic susceptibility in HNSCC are discussed.

  15. Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

    International Nuclear Information System (INIS)

    Lacko, Martin; Braakhuis, Boudewijn J.M.; Sturgis, Erich M.; Boedeker, Carsten C.; Suárez, Carlos; Rinaldo, Alessandra; Ferlito, Alfio; Takes, Robert P.

    2014-01-01

    Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and its incidence is growing. Although environmental carcinogens and carcinogenic viruses are the main etiologic factors, genetic predisposition obviously plays a risk-modulating role, given that not all individuals exposed to these carcinogens experience the disease. This review highlights some aspects of genetic susceptibility to HNSCC: among others, genetic polymorphisms in biotransformation enzymes, DNA repair pathway, apoptotic pathway, human papillomavirus-related pathways, mitochondrial polymorphisms, and polymorphism related to the bilirubin-metabolized pathway. Furthermore, epigenetic variations, familial forms of HNSCC, functional assays for HNSCC risk assessment, and the implications and perspectives of research on genetic susceptibility in HNSCC are discussed

  16. Evaluation and assessment of reflooding models in RELAP5/Mod2.5 and RELAP5/Mod3 codes using Lehigh University and PSI-Neptun bundle experimental data

    Energy Technology Data Exchange (ETDEWEB)

    Sencar, M.; Aksan, N. [Paul Scherrer Institute, Villigen (Switzerland)

    1995-09-01

    An extensive analysis and assessment work on reflooding models of RELAP5/Mod2.5 and, RELAP5/Mod3/v5m5 and RELAP/Mod3/v7j have been performed. Experimental data from LehighUniversityv. and PSI-NEPTUN bundle reflooding experiments have been used for the assessment, since both of these tests cover a broad range of initial conditions. Within the range of these initial conditions, it was tried to identify their separate impacts on the calculated results. A total of six Lehigh University reflooding bundle tests and two PSI-NEPTUN tests with bounding initial conditions are selected for the analysis. Detailed nodalisation studies both for hydraulic and conduction heat transfer were done. On the basis of the results obtained from these cases, a base nodalisation scheme was established. All the other analysis work was performed by using this base nodalisation. RELAP5/Mod2.5 results do not change with renodalisation but RELAP5/Mod3 results are more sensitive to renodalisation. The results of RELAP5/Mod2.5 versions show very large deviations from the used experimental data. These results indicate that some of the phenomenology of the events occurring during the reflooding could not be identified. In the paper, detailed discussions on the main reasons of the deviations from the experimental data will be presented. Since, the results and findings of this study are meant to be a developmental aid, some recommendations have been drawn and some of these have already been implemented at PSI with promising results.

  17. Assessment of RELAP5/MOD3.2 with condensation experiment in the presence of noncondensables in a vertical tube

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyun Sik; No, Hee Cheon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1999-12-31

    The standard RELAP5/MOD3.2 code were assessed with the condensation experiment in the presence of noncondensable gas in a vertical tube of PCCS of CP-1300. There are two wall film condensation models, the default model and the alternative model, in RELAP5/MOD3.2. The experimental apparatus was modeled with the two models, and simulations were performed for several sub-tests to be compared with the experimental results. In overall sense the simulation results showed that the default model of RELAP5/MOD3.2 under-predicts the heat transfer coefficients, while the alternative model over-predicts them throughout the condensing tube. 10 refs., 6 figs. (Author)

  18. Evaluation of the applicability of cladding deformation model in RELAP5/MOD3.2 code for VVER-1000 fuel

    International Nuclear Information System (INIS)

    Vorob'ev, Yu.; Zhabin, O.

    2015-01-01

    Applicability of cladding deformation model in RELAP5/MOD3.2 code is analyzed for VVER-1000 fuel cladding from Zr+1%Nb alloy. Experimental data and calculation model of fuel assembly channel of the core are used for this purpose. The model applicability is tested for the cladding temperature range from 600 to 1200 deg C and pressure range from 1 to 12 MPa. Evaluation results demonstrate limited applicability of built-in RELAP5/MOD3.2 cladding deformation model to the estimation of Zr+1%Nb cladding rupture conditions. The limitations found shall be considered in application of RELAP5/MOD3.2 cladding deformation model in the design-basis accident analysis of VVER reactors

  19. Experiment data report for Semiscale Mod-1 test S-28-3 (steam generator tube rupture test)

    International Nuclear Information System (INIS)

    Gillins, R.L.; Sackett, K.E.

    1977-10-01

    Recorded test data are presented for Test S-28-3 of the Semiscale Mod-1 steam generator tube rupture test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-28-3 was conducted from initial conditions of 15621 kPa and 555 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. Twelve steam generator tube ruptures were simulated by a controlled injection from a heated accumulator into the intact loop hot leg

  20. Assessment of RELAP5/MOD3.2 with condensation experiment in the presence of noncondensables in a vertical tube

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyun Sik; No, Hee Cheon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1998-12-31

    The standard RELAP5/MOD3.2 code were assessed with the condensation experiment in the presence of noncondensable gas in a vertical tube of PCCS of CP-1300. There are two wall film condensation models, the default model and the alternative model, in RELAP5/MOD3.2. The experimental apparatus was modeled with the two models, and simulations were performed for several sub-tests to be compared with the experimental results. In overall sense the simulation results showed that the default model of RELAP5/MOD3.2 under-predicts the heat transfer coefficients, while the alternative model over-predicts them throughout the condensing tube. 10 refs., 6 figs. (Author)

  1. Experiment data report for Semiscale Mod-1 Test S-28-1 (steam generator tube rupture test series)

    International Nuclear Information System (INIS)

    Collins, B.L.; Coppin, C.E.; Sackett, K.E.

    1977-10-01

    Recorded test data are presented for Test S-28-1 of the Semiscale Mod-1 steam generator tube rupture test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-28-1 was conducted from initial conditions of 15 767 kPa and 557 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. Sixty steam generator tube ruptures were simulated by a controlled injection from a heated accumulator into the intact loop hot leg

  2. Experiment data report for semiscale Mod-1 test S-28-2 (steam generator tube rupture test)

    International Nuclear Information System (INIS)

    Patton, M.L.; Sackett, K.E.

    1977-10-01

    Recorded test data are presented for Test S-28-2 of the Semiscale Mod-1 steam generator tube rupture test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-28-2 was conducted from initial conditions of 15 936 kPa and 558 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. For Test S-28-2, accumulator injection into the intact loop hot leg was provided to simulate simulate the rupture of six steam generator tubes

  3. Experiment data report for semiscale Mod-1 test S-28-4 (steam generator tube rupture test)

    International Nuclear Information System (INIS)

    Esparza, V.; Sackett, K.E.

    1977-10-01

    Recorded test data are presented for Test S-28-4 of the Semiscale Mod-1 steam generator tube rupture test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-28-4 was conducted from initial conditions of 15 646 kPa and 557 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. Thirty steam generator tube ruptures were simulated by a controlled injection from a heated accumulator into the intact loop hot leg

  4. Susceptible-infected-recovered and susceptible-exposed-infected models

    International Nuclear Information System (INIS)

    Tome, Tania; De Oliveira, Mario J

    2011-01-01

    Two stochastic epidemic lattice models, the susceptible-infected-recovered and the susceptible-exposed-infected models, are studied on a Cayley tree of coordination number k. The spreading of the disease in the former is found to occur when the infection probability b is larger than b c = k/2(k - 1). In the latter, which is equivalent to a dynamic site percolation model, the spreading occurs when the infection probability p is greater than p c = 1/(k - 1). We set up and solve the time evolution equations for both models and determine the final and time-dependent properties, including the epidemic curve. We show that the two models are closely related by revealing that their relevant properties are exactly mapped into each other when p = b/[k - (k - 1)b]. These include the cluster size distribution and the density of individuals of each type, quantities that have been determined in closed forms.

  5. Host Phenology and Leaf Effects on Susceptibility of California Bay Laurel to Phytophthora ramorum.

    Science.gov (United States)

    Johnston, Steven F; Cohen, Michael F; Torok, Tamas; Meentemeyer, Ross K; Rank, Nathan E

    2016-01-01

    Spread of the plant pathogen Phytophthora ramorum, causal agent of the forest disease sudden oak death, is driven by a few competent hosts that support spore production from foliar lesions. The relationship between traits of a principal foliar host, California bay laurel (Umbellularia californica), and susceptibility to P. ramorum infection were investigated with multiple P. ramorum isolates and leaves collected from multiple trees in leaf-droplet assays. We examined whether susceptibility varies with season, leaf age, or inoculum position. Bay laurel susceptibility was highest during spring and summer and lowest in winter. Older leaves (>1 year) were more susceptible than younger ones (8 to 11 months). Susceptibility was greater at leaf tips and edges than the middle of the leaf. Leaf surfaces wiped with 70% ethanol were more susceptible to P. ramorum infection than untreated leaf surfaces. Our results indicate that seasonal changes in susceptibility of U. californica significantly influence P. ramorum infection levels. Thus, in addition to environmental variables such as temperature and moisture, variability in host plant susceptibility contributes to disease establishment of P. ramorum.

  6. Dynamic insecticide susceptibility changes in Florida populations of Diaphorina citri (Hemiptera: Psyllidae).

    Science.gov (United States)

    Tiwari, Siddharth; Killiny, Nabil; Stelinski, Lukasz L

    2013-02-01

    Five field populations of Diaphorina citri Kuwayama from various regions of Florida were evaluated in 2011 for resistance to commonly used insecticides. Three diagnostic doses (LD50, LD75, and LD95), developed in 2009 using a laboratory susceptible population, were used to measure changes in susceptibility levels of field-collected populations as compared with a susceptible laboratory population. Further reductions in the susceptibility levels of D. citri to chlorpyriphos and fenpropathrin were determined, compared with results obtained in 2010. Mean percent mortality obtained from all five locations was significantly lower than observed with the laboratory susceptible population for all insecticides tested. Previously, expression of five CYP4 genes was implicated in contributing to insecticide metabolism in D. citri. In the current study, we compared the relative expression of these five CYP4 genes and their associated levels of protein expression among field-collected and laboratory susceptible populations. Expression of all CYP4 genes investigated was higher in field-collected populations when normalized against the laboratory susceptible population. There was an increased signal of a band corresponding to a 45 kDa protein in four of the five field populations as measured by the Western blot assay, which suggests increased production of cytochrome P450 enzymes. The current results indicate that insecticide resistance continues to increase in Florida populations ofD. citri, particularly to chlorpyriphos and fenpropathrin. However, there was no further decrease in susceptibility of Florida populations of D. citri to neonicotinoid insecticides in 2011 as compared with previous years.

  7. Nonlinear electromagnetic susceptibilities of unmagnetized plasmas

    International Nuclear Information System (INIS)

    Yoon, Peter H.

    2005-01-01

    Fully electromagnetic nonlinear susceptibilities of unmagnetized plasmas are analyzed in detail. Concrete expressions of the second-order nonlinear susceptibility are found in various forms in the literature, usually in connection with the discussions of various three-wave decay processes, but the third-order susceptibilities are rarely discussed. The second-order susceptibility is pertinent to nonlinear wave-wave interactions (i.e., the decay/coalescence), whereas the third-order susceptibilities affect nonlinear wave-particle interactions (i.e., the induced scattering). In the present article useful approximate analytical expressions of these nonlinear susceptibilities that can be readily utilized in various situations are derived

  8. A Unified Model for Slug Flow Generation Modélisation de la formation des bouchons : vers un modèle stochastique unifié

    Directory of Open Access Journals (Sweden)

    Bernicot M.

    2006-11-01

    Full Text Available In order to improve the global safety and reliability level of multi-phase production systems and to guarantee their economical efficiency, we need a better understanding and control of hydraulic instabilities observed at the outlet of multi-phase sea-lines. This may be obtained through the development of slug flow stochastic models, which must be able to explain:(a The generation of the various types of slug length distributions which are observed on experimental data sets. (b The evolution of these distributions along the sea-lines up to their outlets, where large hydraulic fluctuations may be dangerous for the treatment installations. Based on experimental as well as theoretical arguments, we present such a model with emphasis on slug generation. We give a detailed theoretical analysis, together with a discussion of the underlying assumptions which justify the introduction of this model. Ce résumé contient des formules (*** qui ne peuvent s'afficher à l'écran. Pour garantir à la fois la sûreté de fonctionnement et la rentabilité des systèmes de production avec transport polyphasique, il est nécessaire de mieux comprendre et maîtriser les phénomènes d'instabilité hydraulique dans les conduites polyphasiques. Ceci suppose la mise au point et l'utilisation de Modèles de Simulation des écoulements portant, non seulement sur l'évolution dans le temps et en tout point de la conduite des valeurs moyennes des diverses variables (cf. le modèle TACITE, mais aussi sur leurs aspects stochastiques en prenant spécialement en compte : - les lois statistiques propres des divers mécanismes fondamentaux de formation des bouchons (distribution des longueurs de bouchons de liquide et de poches de gaz; - l'évolution de ces lois statistiques dans le temps et tout le long de la conduite (et ceci, jusqu'à son extrémité, extrémité dont les caractéristiques intéressent tout spécialement l'opérateur de la conduite. Nous présenterons ici

  9. Developmental assessment of RELAP5/MOD3 code against ROSA-IV/TPTF horizontal two-phase flow experiments

    International Nuclear Information System (INIS)

    Kukita, Yutaka; Asaka, Hideaki; Anoda, Yoshinari; Ishiguro, Misako; Tasaka, Kanji; Mimura, Yuichi; Nemoto, Toshiyuki.

    1990-03-01

    A developmental version of the RELAP5/Mod3 code (as of June 1989) was assessed for accuracy using experimental data taken for high-pressure (7MPa) steam-water two-phase flow in a large-diameter (0.18 m) horizontal-pipe test section of the ROSA-IV Two-Phase Flow Test Facility (TPTF). The agreement between the measured and calculated test section void fractions was much better than that for the previous generation of RELAP5 (MOD2). The improvement was achieved primarily due to the code changes with respect to the flow stratification criterion and interfacial-drag calculation scheme. (author)

  10. RELOS.MOD2: a code system for the determination of instationary fission product releases from molten pools

    International Nuclear Information System (INIS)

    Kortz, Ch.; Koch, M.K.; Unger, H.; Funke, F.

    1999-01-01

    For the assessment of molten corium pool source terms, a mechanistic model has been developed to describe the transport of fission products from liquid corium pool surfaces into a colder gas atmosphere. Modelling is based on an approach for diffusive and convective transport processes coupled with thermochemical equilibrium considerations enabling detailed speciation analyses of the fission products released. Both have been implemented into the code system RELOS.MOD2. RELOS.MOD2 sensitivity calculations on possible effects of anticipated uncertainties in the thermo-chemical data on the fission product release predictions are presented. (author)

  11. TRAC-PF1 MOD1 post test calculations of the OECD LOFT Experiment LP-SB-1

    International Nuclear Information System (INIS)

    Allen, E.J.

    1990-04-01

    Analysis of the small, hot leg break, OECD LOFT Experiment LP-SB-1. using the ''best-estimate'' computer code TRAC-PF1/MOD1 is presented. Descriptions of the LOFT facility and the LP-SB-1 experiment are given and development of the TRAC-PF1/MOD1 input model is detailed. The calculations performed in achieving the steady state conditions, from which the experiment was initiated, and the specification of experimental boundary conditions are outlined. 24 refs., 66 figs., 12 tabs

  12. A review of analyses of LOFT and semiscale tests made at IDAHO National Engineering Laboratory using RELAP5/MOD1

    International Nuclear Information System (INIS)

    Hall, P.C.

    1984-03-01

    Within the LOFT and Semiscale programs at INEL, many post-test analysis calculations have been performed using RELAP5/MOD1. In this report, these calculations are reviewed from the standpoint of assessing the performance of the code. Because the calculations were spread over a number of years, different cycles of RELAP5/MOD1 have been employed. Rather than explicitly assessing several cycles of the code, a more general view has been adopted and an attempt has been made to identify those areas in which the code is systematically successful or alternatively, frequently experiences difficulties. (author)

  13. Scaling criteria and an assessment of Semiscale Mod-3 scaling for small-break loss-of-coolant transients

    International Nuclear Information System (INIS)

    Larson, T.K.; Anderson, J.L.; Shimeck, D.J.

    1982-01-01

    Various methods of scaling fluid thermal-hydraulic test facilities and their relative merits and disadvantages are examined in light of nuclear reactor safety considerations. Particular emphasis is placed on examination of the scaling of the Semiscale Mod-3 system and determination of thermal-hydraulic phenomena thought to be important during a small break loss-of-coolant accident in a pressurized water nuclear reactor. The influence of geometric and dynamic scaling concerns in the Mod-3 system on small break behavior are addressed from an engineering viewpoint and corrective measures contemplated or required to make results from Semiscale tests more meaningful relative to expected PWR response are discussed

  14. RELAP5/MOD3 analysis of a heated channel in downflow

    International Nuclear Information System (INIS)

    Dimenna, R.A.; Qureshi, Z.H.; Boman, A.L.

    1993-01-01

    The onset of flow instability (OFI) is a significant phenomenon affecting the determination of a safe operating power limit in the Savannah River Site production reactors. Tests performed at Columbia University for a single tube with uniform axial and azimuthal heating have been analyzed with RELAP5/NPR, Version 0, a version of RELAP5/MOD3. The tests include water flow rates from 3.2 x l0 -4 - 2.l x 10 -3 m 3 /s (5 - 33 gpm), Reynolds numbers from 30,000 - 400,000, and surface heat fluxes from 0 - 3.2 x l0 6 w/m 2 (0 - 1,000,000 Btu/hr- ft 2 ). Pressure drop versus flow rate curves were mapped for both fixed pressure boundary conditions and fixed flow boundary conditions. RELAP5/MOD3 results showed fair agreement with data for both types of boundary conditions, and good internal consistency between calculations using the two different types of boundary conditions. Under single-phase unheated conditions, the code overpredicted the pressure drop by 22 - 34%. Under single-phase heated conditions, the overprediction increased to as much as 55%. For those tests where two-phase conditions were observed at the channel exit, RELAP5 predicted lower flows than seen in the tests before voiding occurred

  15. Design and operation of the RFX-mod plasma shape control system

    Energy Technology Data Exchange (ETDEWEB)

    Marchiori, G., E-mail: giuseppe.marchiori@igi.cnr.it [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Finotti, C. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Kudlacek, O. [Università di Padova, Padova (Italy); Villone, F. [Dipartimento di Ingegneria Elettrica e dell’Informazione (DIEI), Università di Cassino (Italy); Zanca, P. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Abate, D. [Dipartimento di Ingegneria Elettrica e dell’Informazione (DIEI), Università di Cassino (Italy); Cavazzana, R. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Jackson, G.L.; Luce, T.C. [General Atomics, San Diego, CA (United States); Marrelli, L. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy)

    2016-10-15

    Highlights: • Linearized plasma response model of RFX-mod Tokamak Double/Single Null discharges. • Model based design of a vertical stability control system. • Model based design of a plasma shape LQG control system with Kalman state estimator. • Real time plasma boundary reconstruction algorithm. • Tracking and disturbance rejection experimental tests. - Abstract: The aim of executing Single Null discharges in RFX-mod operating as a Tokamak led to the design and implementation of a plasma shape feedback control system. A fully model-based approach was followed which allowed dealing with critical issues such as the presence of a conducting shell, the strong coupling of the poloidal field coils and the voltage limits of the power supplies. A Linear Quadratic regulator and a Kalman state estimator were designed and implemented in the real time MARTe framework together with an algorithm for the real-time plasma boundary reconstruction. The problem of a number of sensors along the poloidal direction adequate only for circular discharges was also successfully tackled. The development of the system and its performances in terms of tracking and disturbance rejection capability are presented in the paper.

  16. Design of a New Optical System for Alcator C-Mod Motional Stark Effect Diagnostic

    International Nuclear Information System (INIS)

    Ko, Jinseok; Scott, Steve; Bitter, Manfred; Lerner, Scott

    2009-01-01

    The motional Stark effect (MSE) diagnostic on Alcator C-Mod uses an in-vessel optical system (five lenses and three mirrors) to relay polarized light to an external polarimeter because port access limitations on Alcator C-Mod preclude a direct view of the diagnostic beam. The system experiences unacceptable, spurious drifts of order several degrees in measured pitch angle over the course of a run day. Recent experiments illuminated the MSE diagnostic with polarized light of fixed orientation as heat was applied to various optical elements. A large change in measured angle was observed as two particular lenses were heated, indicating that thermal-stress-induced birefringence is a likely cause of the spurious variability. Several new optical designs have been evaluated to eliminate the affected in-vessel lenses and to replace the focusing they provide with curved mirrors; however, ray tracing calculations imply that this method is not feasible. A new approach is under consideration that utilizes in situ calibrations with in-vessel reference polarized light sources. 2008 American Institute of Physics.

  17. Assessment of a new interfacial friction correlation in TRAC-BD1/MOD1

    International Nuclear Information System (INIS)

    Analytis, G.T.

    1986-01-01

    Analysis of a number of 5-bar (and one 1-bar) boiloff experiments in the electrically heated 33-rod bundle NEPTUN at the Swiss Federal Institute for Reactor Research by TRAC-BD1 version 12 and MOD1 has shown that the code consistently underpredicts the collapsed liquid level histories, hence predicting earlier critical heat fluxes and higher peak rod surface temperatures than the measurements showed. Moreover, recent work has demonstrated that these differences can be attributed to the bubbly/churn interfacial friction model in TRAC-BD1 (resulting in rather large interfacial drag) whose appropriateness for rod bundles is questionable; decreasing the interfacial drag resulted in excellent agreement between measurements and code predictions. Recent analysis of boiloff experiments with the French code CATHARE and with a bubbly/churn interfacial drag force f/sub i/ similar to the one of TRAC-BD1 has also resulted in the underprediction of collapsed liquid level histories. In this work, it was shown that the usual vapor drift velocity correlations (through which f/sub i/ is derived) for this flow regime developed for tubes are not appropriate for rod bundles. Moreover, a new f/sub i/ correlation for bubbly/churn flow in rod bundles was developed based on the Froude number. The authors have modified this correlation slightly, implemented it in TRAC-BD1/MOD1, and reanalyzed most of the boiloff experiments in NEPTUN

  18. Progress on MOD/RABiTS{sup TM} 2G HTS wire

    Energy Technology Data Exchange (ETDEWEB)

    Rupich, M.W.; Zhang, W.; Li, X.; Kodenkandath, T.; Verebelyi, D.T.; Schoop, U.; Thieme, C.; Teplitsky, M.; Lynch, J.; Nguyen, N.; Siegal, E.; Scudiere, J.; Maroni, V.; Venkataraman, K.; Miller, D.; Holesinger, T.G

    2004-10-01

    The development of the second generation (2G) high temperature superconducting wire has advanced beyond initial laboratory demonstrations and is now focused on developing and testing high critical current conductor designs required for commercial applications. The approach pursued at American Superconductor for 2G wire manufacturing is based on the combination of the RABiTS{sup TM} substrate-buffer technology with metal organic deposition (MOD) of the YBCO layer. This MOD/RABiTS{sup TM} approach has been demonstrated in 10 m lengths with critical currents of up to 184 A/cm-width ({approx}2.3 MA/cm{sup 2}) and in short length with critical currents of up to 270 A/cm-width ({approx}3.4 MA/cm{sup 2}). In addition to a high critical current, the superconducting wire must also meet stringent mechanical and electrical stability requirements that vary by application. Commercially viable architectures designed to meet these specifications have been fabricated and tested. Wires manufactured by this process have been successfully tested in prototype cable and coil applications.

  19. Experiment data report for semiscale Mod-1 test S-04-1 (baseline ECC test)

    International Nuclear Information System (INIS)

    Crapo, H.S.; Collins, B.L.; Sackett, K.E.

    1976-09-01

    Recorded test data are presented for Test S-04-1 of the Semiscale Mod-1 Baseline ECC Test Series. This test is among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor system. Test S-04-1 was conducted from an initial cold leg fluid temperature of 542 0 F and an initial pressure of 2,263 psia. A simulated double-ended offset shear cold leg break was used to investigate the system response to a depressurization and reflood transient using system volume scaled coolant injection parameters. System flow was set to achieve a core fluid temperature differential of 66 0 F at a full core power of 1.6 MW. The flow resistance of the intact loop was based on core area scaling. An electrically heated core with a flat radial power profile was used in the pressure vessel to simulate the effects of a nuclear core. During system depressurization, core power was reduced from the initial level of 1.6 MW in such a manner as to simulate the surface heat flux response of nuclear fuel rods until such time that departure from nucleate boiling might occur. Blowdown to the pressure suppression system was accompanied by simulated emergency core cooling injection into both the intact and broken loops. Coolant injection was continued until test termination at 200 seconds after initiation of blowdown

  20. Experiment data report for Semiscale Mod-1 test S-02-5 (blowdown heat transfer test)

    International Nuclear Information System (INIS)

    1975-12-01

    Recorded test data are presented for Test S-02-5 of the Semiscale Mod-1 blowdown heat transfer test series. Test S-02-5 is one of several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a water-cooled nuclear reactor system and to provide data for the assessment of the Loss-of-Fluid Test (LOFT) design basis. Test S-02-5 was conducted from an initial cold leg fluid temperature of 544 0 F and an initial pressure of 2,253 psia. A simulated double-ended offset shear cold leg break was used to investigate the system response to a depressurization transient with full core power (1.6 MW). An electrically heated core was used in the pressure vessel to simulate the effects of a nuclear core. System flow was set to achieve the full design core temperature differential of 66 0 F. The flow resistance of the intact loop was based on core area scaling. During system depressurization, core power was reduced from the initial level of 1.6 MW in such a manner as to simulate the surface heat flux response of the LOFT nuclear fuel rods until such time that departure from nucleate boiling occurs

  1. Compatibility of dip-coated Er2O3 coating by MOD method with liquid Li

    International Nuclear Information System (INIS)

    Zhang Dongxun; Kondo, Masatoshi; Tanaka, Teruya; Muroga, Takeo; Valentyn, Tsisar

    2011-01-01

    An electrical insulating ceramic coating on the self-cooled lithium blanket is a promising technology for suppressing MHD pressure drop in the blanket system. Er 2 O 3 is thought to be one of the potential candidate materials for ceramic coatings because of their high electrical resistivity and high compatibility with liquid lithium. In this study, Er 2 O 3 coating was fabricated on the ferritic steels by dip-coating method with MOD (metal organic decomposition) liquid precursor followed by baking in different atmosphere. The coated specimens were immersed at 500 o C in the static liquid lithium to test the compatibility. It was shown that the compatibility of the coating was degraded when Fe 2 O 3 or Fe 3 O 4 was formed as the main composition of the substrate oxidation layer during the baking. On the other hand, thin Cr 2 O 3 layer in the substrate oxidation layer did not influence the stability of Er 2 O 3 coating. Atmosphere controlling for suppressing the substrate oxidation, especially Fe 2 O 3 or Fe 3 O 4 , during the baking is shown to be essential for the compatibility of MOD Er 2 O 3 coating on ferritic steels.

  2. Analysis of the General Electric Company swell tests with RELAP4/MOD7

    International Nuclear Information System (INIS)

    Fischer, S.R.; Hendrix, C.E.

    1979-01-01

    The RELAP4/MOD7 nuclear reactor transient analysis code, presently being developed by EG and G Idaho, Inc., will incorporate several significant improvements over earlier versions of RELAP4. As part of the development of RELAP4/MOD7, a thorough assessment of the capability of the code to simulate water reactor LOCA phenomena is being made. This assessment is accomplished in part by comparing results from code calculations with test data from experimental facilities. Simulations of the General Electric Company (GE) level swell tests were performed as part of the code checkout. In these tests, a pressurized vessel partially filled with nearly saturated water was blown down through a simulated break located near the top of the vessel. Comparison of RELAP4 calculations with data from these experiments indicates that the code has the capability to model the unequal phase velocity flow and resulting density gradients that might occur in a BWR steam line break transient. Comparisons of RELAP4 calculations with data from two level swell experiments are presented

  3. Evaluation of the RELAP4/MOD6 thermal-hydraulic code

    International Nuclear Information System (INIS)

    Haigh, W.S.; Margolis, S.G.; Rice, R.E.

    1978-01-01

    The NRC RELAP4/MOD6 computer code was recently released to the public for use in thermal-hydraulic analysis. This code has a unique new capability permitting analysis of both the blowdown and reflood portions of a postulated pressurized water reactor (PWR) loss-of-coolant accident (LOCA). A principal code evaluation objective is to assess the accuracy of the code for computing LOCA behavior over a wide range of system sizes and scaling concepts. The scales of interest include all LOCA experiments and will ultimately encompass full-sized PWR systems for which no experiments or data are available. Quantitative assessment of the accuracy of the code when it is applied to large PWR systems is still in the future. With RELAP4/MOD6, however, a technique has been demonstrated for using results derived from small-scale blowdown and reflood experiments to predict the accuracy of calculations for similar experiments of significantly different scale or component size. This demonstration is considered a first step in establishing confidence levels for the accuracy of calculations of a postulated LOCA

  4. Core heatup prediction during SB LOCA with RELAP5/MOD3.2.2 Gamma

    International Nuclear Information System (INIS)

    Parzer, I.; Mavko, B.; Petelin, S.

    2001-01-01

    The paper focuses on the phenomena leading to core uncovering and heatup during the SB LOCA and the ability of RELAP5/MOD3.2.2 Gamma to predict core overheating. The code prediction has been compared to the three experiments, one conducted on the separate effect test facility NEPTUN in Switzerland and the other two conducted on two integral test facilities, PMK-2 in Hungary and PACTEL facility in Finland. In the case of a series of boiloff experiments performed on the NEPTUN test facility the influence of the two correlations available in MOD3.2.2 Gamma for determining interphase drag has been studied. In the case of IAEA-SPE-4 experiment simulation on PMK-2 facility the main goal of the analysis was to study the adequate modeling of the hexagonal core channel with 19-rod bundle and the phenomena during the core uncovering. The third analyzed experiment, OECD-ISP-33, was performed on PACTEL facility to study different natural circulation modes during SB LOCA. The analysis also focused on the final stage of this SB LOCA experiment, when core dryout and heatup was observed due to gradual emptying of the primary system. Following the experience the appropriate modeling options have been used to achieve better representation of the important phenomena during the SB LOCA.(author)

  5. Validation of CATHENA MOD-3.5/Rev0 for single-phase water hammer

    International Nuclear Information System (INIS)

    Beuthe, T.G.

    2000-01-01

    This paper describes work performed to validate the system thermalhydraulics code CATHENA MOD-3.5c/Rev0 for single-phase water hammer. Simulations were performed and are compared quantitatively against numerical tests and experimental results from the Seven Sisters Water Hammer Facility to demonstrate CATHENA can predict the creation and propagation of pressure waves when valves are opened and closed. Simulations were also performed to show CATHENA can model the behaviour of reflected and transmitted pressure waves at area changes, dead ends, tanks, boundary conditions, and orifices in simple and more complex piping systems. The CATHENA results are shown to calculate pressure and wave propagation speeds to within 0.2% and 0.5% respectively for numerical tests and within 3.3% and 5% for experimental results respectively. These results are used to help validate CATHENA for use in single-phase water hammer analysis. They also provide assurance that the fundamental parameters needed to successfully model more complex forms of water hammer are accounted for in the MOD-3.5c/Rev0 version of CATHENA, and represent the first step in the process to validate the code for use in modelling two-phase water hammer and condensation-induced water hammer. (author)

  6. Thermal enhancement cartridge heater modified (TECH Mod) tritium hydride bed development, Part 1 - Design and fabrication

    Energy Technology Data Exchange (ETDEWEB)

    Klein, J.E.; Estochen, E.G. [Savannah River National Laboratory, Aiken, SC (United States)

    2015-03-15

    The Savannah River Site (SRS) tritium facilities have used first generation (Gen1) LaNi{sub 4.25}Al{sub 0.75} (LANA0.75) metal hydride storage beds for tritium absorption, storage, and desorption. The Gen1 design utilizes hot and cold nitrogen supplies to thermally cycle these beds. Second and third generation (Gen2 and Gen3) storage bed designs include heat conducting foam and divider plates to spatially fix the hydride within the bed. For thermal cycling, the Gen2 and Gen3 beds utilize internal electric heaters and glovebox atmosphere flow over the bed inside the bed external jacket for cooling. The currently installed Gen1 beds require replacement due to tritium aging effects on the LANA0.75 material, and cannot be replaced with Gen2 or Gen3 beds due to different designs of these beds. At the end of service life, Gen1 bed desorption efficiencies are limited by the upper temperature of hot nitrogen supply. To increase end-of-life desorption efficiency, the Gen1 bed design was modified, and a Thermal Enhancement Cartridge Heater Modified (TECH Mod) bed was developed. Internal electric cartridge heaters in the new design to improve end-of-life desorption, and also permit in-bed tritium accountability (IBA) calibration measurements to be made without the use of process tritium. Additional enhancements implemented into the TECH Mod design are also discussed. (authors)

  7. Detailed Post Analysis of HERMES-HALF Experiment using RELAP5/MOD3

    Energy Technology Data Exchange (ETDEWEB)

    Park, Rae Joon; Kang, Kyung Ho; Ha, Kwang Soon; Cho, Young Ro; Koo, Kil Mo; Kim, Sang Baik; Kim, Hee Dong

    2005-03-15

    As part of a study on a two-phase natural circulation flow between the outer reactor vessel and the insulation material in the reactor cavity under an external reactor vessel cooling of APR1400, a HERMES-HALF experiment has been analyzed to verify and evaluate the experimental results using the RELAP5/MOD3 computer code. The RELAP5/MOD3 results have shown that the water circulation mass flow rate is very similar to the experimental results of the HERMES-HALF, in general. Increases in the water inlet area and the water level in the reactor cavity lead to an increase in the water circulation mass flow rate. In the small water inlet area condition, the lower value of the water outlet area has an effect on the water circulation mass flow rate, but the larger value of this has no effect. The air injection mass flow rate has no effect on the water circulation mass flow rate when it is greater than 40 % at the small water inlet area condition. However, an increase in the air injection mass flow rate leads to an increase in the water circulation mass flow rate. In the large water inlet area condition, increases in the water outlet area and the air injection mass flow rate lead to an increase in the water circulation mass flow rate. As the water outlet moves to a lower position, the water circulation mass flow rate slowly increases.

  8. RELAP5/MOD2 implementation on various mainframes including the IBM and SX-2 supercomputer

    International Nuclear Information System (INIS)

    DeForest, D.L.; Hassan, Y.A.

    1987-01-01

    The RELAP5/MOD2 (cycle 36.04) code is a one-dimensional, two-fluid, nonequilibrium, nonhomogeneous transient analysis code designed to simulate operational and accident scenarios in pressurized water reactors (PWRs). System models are solved using a semi-implicit finite difference method. The code was developed at EG and G in Idaho Falls under sponsorship of the US Nuclear Regulatory Commission (NRC). The major enhancement from RELAP5/MOD1 is the use of a six-equation, two-fluid nonequilibrium and nonhomogeneous model. Other improvements include the addition of a noncondensible gas component and the revision and addition of drag formulation, wall friction, and wall heat transfer. Several test cases were run to benchmark the IBM and SX-2 installations against the CDC computer and the CRAY-2 and CRAY/XMP. These included the Edward's pipe blow-down and two separate reflood cases developed to simulate the FLECHT-SEASET reflood test 31504 and a postcritical heat flux (CHF) test performed at Lehigh University

  9. An assessment of the CORCON-MOD3 code. Part 1: Thermal-hydraulic calculations

    International Nuclear Information System (INIS)

    Strizhov, V.; Kanukova, V.; Vinogradova, T.; Askenov, E.; Nikulshin, V.

    1996-09-01

    This report deals with the subject of CORCON-Mod3 code validation (thermal-hydraulic modeling capability only) based on MCCI (molten core concrete interaction) experiments conducted under different programs in the past decade. Thermal-hydraulic calculations (i.e., concrete ablation, melt temperature, melt energy, concrete temperature, and condensible and non-condensible gas generation) were performed with the code, and compared with the data from 15 experiments, conducted at different scales using both simulant (metallic and oxidic) and prototypic melt materials, using different concrete types, and with and without an overlying water pool. Sensitivity studies were performed in a few cases involving, for example, heat transfer from melt to concrete, condensed phase chemistry, etc. Further, special analysis was performed using the ACE L8 experimental data to illustrate the differences between the experimental and the reactor conditions, and to demonstrate that with proper corrections made to the code, the calculated results were in better agreement with the experimental data. Generally, in the case of dry cavity and metallic melts, CORCON-Mod3 thermal-hydraulic calculations were in good agreement with the test data. For oxidic melts in a dry cavity, uncertainties in heat transfer models played an important role for two melt configurations--a stratified geometry with segregated metal and oxide layers, and a heterogeneous mixture. Some discrepancies in the gas release data were noted in a few cases

  10. Edge plasma physics modifications due to magnetic ripple in RFX-mod

    International Nuclear Information System (INIS)

    Scarin, P.; Agostini, M.; Carraro, L.; Cavazzana, R.; Ciaccio, G.; De Masi, G.; Spizzo, G.; Spolaore, M.; Vianello, N.

    2015-01-01

    The edge of the RFX-mod (R = 2 m, a = 0.46 m) Reversed Field Pinch is characterized by weak magnetic chaos affecting ion and electron diffusion. Edge particle transport is strongly influenced by a toroidal asymmetry caused by magnetic islands. An ambipolar radial electric field ensures local neutrality and possesses the same symmetry as the parent magnetic ripple: the result is the modulation of the perpendicular flow, with a slowing-down at the island X-point. In this paper we present a complete statistical analysis, over a large database of RFX-mod discharges, of the edge properties as they are modified by the magnetic topology: the plasma wall footprint follows the helical shape of the dominant central mode (m/n = 1/7), with an increase of H α emission and electron density corresponding to the O-point of the inner magnetic island. Edge turbulence is modified by the magnetic topology, being generated in the O-point region and damped near the X-point

  11. Thermal Aging Evaluation of Mod. 9Cr-1Mo Steel using Nonlinear Rayleigh Waves

    Energy Technology Data Exchange (ETDEWEB)

    Joo, Young-Sang; Kim, Hoe-Woong; Kim, Jong-Bum [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Marino, Daniel; Kim, Jin-Yeon; Jacobs, L.J [Georgia Institute of Technology, Atlanta (United States); Ruiz, Alberto [UMSNH, Morelia (Mexico)

    2014-10-15

    Thermal aging can pose a high risk to decreases in the mechanical properties such as strength or creep resistance. This can lead to an unexpected failure during long term operation. Nonlinear NDE techniques are preferred over conventional NDE techniques (linear ultrasonic measurements) because nonlinear ultrasonic techniques have shown their capability to detect a microstructural damage in the structures undergoing fatigue and creep. These nonlinear ultrasonic techniques make use of the fact that the dislocation density increases, which will create a nonlinear distortion of an ultrasonic wave; this damage causes the generation of measurable higher harmonic components in an initially mono-chromatic ultrasonic signal. This study investigates the recently developed non-contact nonlinear ultrasonic technique to detect the microstructural damage of mod. 9Cr-1Mo steel based on nonlinear Rayleigh wave with varying propagation distances. Nonlinear Rayleigh surface wave measurements using a non-contact, air-coupled ultrasonic transducer have been applied for the thermal aging evaluation of modified 9Cr-1Mo ferritic-martensitic steel. Thermal aging for various heat treatment times of mod.. 9Cr-1Mo steel specimens is performed to obtain the nucleation and growth of precipitated particles in specimens. The amplitudes of the first and second harmonics are measured along the propagation distance and the relative nonlinearity parameter is obtained from these amplitudes. The relative nonlinearity parameter shows a similar trend with the Rockwell C hardness.

  12. RELAP/REFLA (Mod 0): a system reflooding analysis computer program

    International Nuclear Information System (INIS)

    Fujiki, Kazuo; Murao, Yoshio; Shimooke, Takanori.

    1981-03-01

    A new computer code RELAP/REFLA has been developed, aiming at analyses of the core reflooding phenomena during the postulated loss-of-coolant accident of PWRs. The code was originated from the combination of two distinct codes, RELAP4-FLOOD and REFLA-1D. The characteristics of the code are: (1) Kinematical model based on the observation and analysis of quench experiments is used for the thermal-hydraulic analysis of reflooding core, (2) it has the capability to analyse the reflooding phenomena in an arbitrary type of PWR or experimental facility, including the system feedback effects, (3) the flow paths in the actual system are represented by the combination of 1-dimentional flow paths, and vapor-liquid equilibrium model is applied except the reflooding core. This report is a code manual of RELAP/REFLA (version Mod 0) and contains the descriptions of the basic models, basic equations, code structure and input format. The calculated results of two kinds of sample problems, i.e., reflooding problem on the 4 loop PWR and FLECHT-SET experiment, are also presented. Relatively close agreement between FLECHT-SET data and the calculated results was obtained for the lower portion of the core, but poor agreement for the temperature histories in the upper core and carryover ratio. Running speed and core memory size are almost equal to those of RELAP 4/Mod 3. (author)

  13. Experiment data report for Semiscale Mod-1 Test S-05-2 (alternate ECC injection test)

    International Nuclear Information System (INIS)

    Feldman, E.M.; Collins, B.L.; Sackett, K.E.

    1977-02-01

    Recorded test data are presented for Test S-05-2 of the Semiscale Mod-1 alternate emergency core coolant (ECC) injection test series. This test is one of several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-2 was conducted from an initial cold leg fluid temperature of 545 0 F and an initial pressure of 2263 psia. A simulated double-ended offset shear cold leg break was used to investigate core and system response to a depressurization and reflood transient with ECC injection at the intact loop pump suction and broken loop cold leg. A reduced lower plenum volume was used for this test to more accurately represent the lower plenum of a PWR, based on system volume scaling. System flow was set to achieve a core fluid temperature differential of 65 0 F at a core power level of 1.44 MW. The flow resistance of the intact loop was based on core area scaling. An electrically heated core with a slightly peaked radial power profile was used in the pressure vessel to simulate the predicted surface heat flux of nuclear fuel rods during a loss-of-coolant accident

  14. A comparison of the RELAP5/MOD3 code with the IIST natural circulation experiments

    International Nuclear Information System (INIS)

    Ferng, Y.M.; Lee, C.H.

    1995-01-01

    A series of experiments dealing with variable secondary-side cooling conditions have been conducted at the IIST facility, including the natural circulation experiments under the secondary-side conditions of normal feedwater, loss of feedwater, and full of air. Different cooling conditions at the secondary side directly affect the primary-to-secondary heat transfer and then may influence the heat removal capability of natural circulation in the primary system. The corresponding analytical work is performed using the RELAP5/MOD3 code. Good agreement is reached both qualitatively and quantitatively between the experimental data and calculated results, demonstrating the satisfactory assessment of RELAP5/MOD3 code compared with the IIST natural circulation experiments. The cooling conditions at the secondary side have no significant effect on the heat removal capability of natural circulation as long as sufficient coolant exists on the steam generator secondary side, based on current IIST data and analytical results. Continuous increase of the core temperature and system pressure is also demonstrated experimentally and analytically in the test with the secondary side dry for the sake of deficient heat transfer capability at the steam generator secondary system

  15. Transport and Stability in C-Mod ITBs in Diverse Regimes

    Science.gov (United States)

    Fiore, C. L.; Ernst, D. R.; Howard, N. T.; Kasten, C. P.; Mikkelsen, D.; Reinke, M. L.; Rice, J. E.; White, A. E.; Rowan, W. L.; Bespamyatnov, I.

    2012-10-01

    Internal Transport Barriers (ITBs) in C-Mod feature highly peaked density and pressure profiles and are typically induced by the introduction of radio frequency power in the ion cyclotron range of frequencies (ICRF) with the second harmonic of the resonance for minority hydrogen ions positioned off-axis at the plasma half radius on either the low or high field side of the plasma. These ITBs are formed in the absence of particle or momentum injection, and with monotonic q profiles with qminITB dynamics in a reactor relevant regime. Recently, linear and non-linear gyrokinetic simulations have demonstrated that changes in the ion temperature and plasma rotation profiles, coincident with the application of off-axis ICRF heating, contribute to greater stability to ion temperature gradient driven fluctuation in the plasma. This results in reduced turbulent driven outgoing heat flux. To date, ITB formation in C-Mod has only been observed in EDA H-mode plasmas with moderate (2-3 MW) ICRF power. Experiments to explore the formation of ITBs in other operating regimes such as I-mode and also with high ICRF power are being undertaken to understand further the process of ITB formation and sustainment, especially with regard to turbulent driven transport.

  16. Calculations of flow oscillations during reflood using RELAP4/MOD6

    International Nuclear Information System (INIS)

    Chen, Y.S.; Fischer, S.R.; Sullivan, L.H.

    1979-01-01

    RELAP4/MOD6 is an analytical computer code which can be used for best-estimate analysis of LWR reactor system blowdown and reflood response to a postulated LOCA. In this study, flow oscillations in the PKL reflood test K5A were investigated using RELAP4/MOD6. Both calculated and measured oscillations exhibited transient characteristics of density-wave and pressure-drop oscillations. The calculated average core mixture level rising rate agrees closely with the test data. Several mechanisms which appear to be responsible for initiation and continuation of calculated or experimental reflood flow oscillations are (a) the coupling between the vapor generation in the core channel and the U-tube geometrical arrangement of a downcomer and a heated core; (b) the inherent low core inlet resistance and the high system outlet resistance; (c) the dependence of heat transfer rate on mass flow rate especially in the dispersed flow ially in the dispersed flow regime; (d) the amount of the liquid entrainment fraction of the heated core channel

  17. RELAP5/MOD3.3 assessment against MSIV closure events in Krsko NPP

    International Nuclear Information System (INIS)

    Parzer, I.

    2002-01-01

    The paper presents RELAP5/MOD3.3 analysis of two abnormal events occurred in Krsko NPP originating from sudden closure of Main Steam Isolation Valve (MSIV). Both events occurred before the SG replacement in 2000, the first one in September 1995 and the second one in January 1997. Valuable plant data were obtained from real plant transients and the RELAP5 code assessment was performed. Recently the last frozen version RELAP5/MOD3.3 has been released, before merging with another best-estimate thermalhydraulic system code TRAC into an integrated code. It is thus of utmost importance to assess models built in RELAP5 code against real plant transients before the code merger. A full twoloop plant model, developed at Jozef Stefan Institute (JSI), has been used for the analyses. The model includes old Westinghouse D4 type steam generators (SGs) with assumed 18% Utubes plugged in both steam generators. In the first case a malfunction in the MSIV in SG-1 caused inadvertent valve closure, while in the second case the valve stem has been broken in the SG-2, which also caused sudden valve closure.(author)

  18. Analysis of loss of offsite power transient using RELAP5/MOD1/NSC

    International Nuclear Information System (INIS)

    Kim, Hho Jung; Chung, Bub Dong; Lee, Young Jin; Kim, Jin Soo

    1986-01-01

    System thermal-hydraulic parameters and simulated, using the best-estimate system code(RELAP5/MOD1/NSC), based upon the sequence of events for the KNU1( Korea Nuclear Unit 1) loss of offsite power transient at 77.5% power which occurred on June 9,1981. The results are compared with the actual plant transient data and show good agreements. After the flow coastdown following the trips of both reactor coolant pumps, the establishment of natural circulation by the temperature difference between the hot and the cold legs is confirmed. The calculated reactor coolant flowrate closely approximate the plant data indicating the validity of relevant thermal-hydraulic models in the RELAP5/MOD1/NSC. Results also show that the sufficient heat removal capability is secured by the appropriate supply of the auxiliary feedwater without the operation of S/G PORVs. In addition, a scenario accident at full power, based upon the same sequence of events described above, is also analysed and the results confirmed that the safety of KNU1 is secured by the appropriate operation of the S/G PORVs coupled with the supply of auxiliary feedwater which ensures sufficient heat removal capability. The characteristics of the non-safety related components such as the turbine stop valve closing time, S/G PORV setting etc. are recognized to be important in the transient analyses on a bestestimate basis. (Author)

  19. FUDA MOD-2: a computer program for simulation the performance of fuel element validation exercise

    International Nuclear Information System (INIS)

    Chouhan, S.K.; Tripathi, R.M.; Prasad, P.N.; Chauhan, Ashok

    2014-01-01

    The PHWR fuel element performance is evaluated using the fuel analysis computer code FUDA MOD2. It is specifically written for performance simulation of UO 2 fuel pellet, located in zirconium alloy sheath operating under coolant pressure. For specific element power histories, the code investigates the variables and their interactions that govern fuel element performance. The input data requires pellet dimensions, element dimensions, sheath properties, heat transfer data, thermal hydraulic parameters of coolant, the inner filler gas composition, flux gradient and linear heat ratings (LHR) at different burn up. The output data generated by the code are radial temperature profile of fuel and sheath, fuel sheath-gap heat transfer coefficient, fission gas generated and released, fission gas pressure, sheath stress and strain for different burn-up zones. The code has been verified against literature data and post irradiation examinations carried out. It is also bench marked against various international fuel element simulation programmes available with water cooled reactors operating countries. The present paper describes the FUDA MOD2 code verification studies carried out using the literature data and post irradiation examination data. (author)

  20. Three-dimensional equilibria and transport in RFX-mod: A description using stellarator tools

    International Nuclear Information System (INIS)

    Gobbin, M.; Bonfiglio, D.; Lorenzini, R.; Marrelli, L.; Martin, P.; Martines, E.; Momo, B.; Predebon, I.; Puiatti, M. E.; Spizzo, G.; Terranova, D.; Boozer, A. H.; Cooper, A. W.; Escande, D. F.; Hirshman, S. P.; Lore, J.; Sanchez, R.; Spong, D. A.; Pomphrey, N.

    2011-01-01

    RFX-mod self-organized single helical axis (SHAx) states provide a unique opportunity to advance 3D fusion physics and establish a common knowledge basis in a parameter region not covered by stellarators and tokamaks. The VMEC code has been adapted to the reversed-field pinch (RFP) to model SHAx equilibria in fixed boundary mode with experimental measurements as constraint. The averaged particle diffusivity over the helical volume, estimated with the Monte Carlo code ORBIT, has a neoclassical-like dependence on collisionality and does not show the 1/ν trend of un-optimized stellarators. In particular, the helical region boundary, corresponding to an electron transport barrier with zero magnetic shear and improved confinement, has been investigated using numerical codes common to the stellarator community. In fact, the DKES/PENTA codes have been applied to RFP for local neoclassical transport computations, including radial electric field, to estimate thermal diffusion coefficients in the barrier region for typical RFX-mod temperature and density profiles. A comparison with power balance estimates shows that residual chaos due to secondary tearing modes and small-scale turbulence still contribute to drive anomalous transport in the barrier region.