Implementación de un sistema de telediagnóstico de tuberculosis y determinación de multidrogorresistencia basada en el método Mods en Trujillo, Perú

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Luis Rodríguez

Full Text Available Objetivos. Implementar un sistema para el diagnóstico remoto de tuberculosis y multidrogorresistencia (MDR usando el método Microscopic-Observation Drug Susceptibility Assay (MODS en el Laboratorio de Micobacterias del Centro de Excelencia en Tuberculosis de Trujillo (CENEX-Trujillo. El sistema incluyó una variante de un algoritmo de reconocimiento de Mycobacterium tuberculosis recientemente reportado a partir de imágenes digitales de cultivos MODS de muestras de esputo. Materiales y métodos. Se optimizó un algoritmo de reconocimiento por medio de un reentrenamiento del modelo estadístico basado en imágenes digitales de cultivos MODS provenientes del Laboratorio de Micobacterias del CENEX-Trujillo. Se obtuvieron imágenes de 50 cultivos MODS positivos de pacientes con sospecha de tuberculosis multidrogorresistente entre enero y octubre de 2012 en el CENEX-Trujillo. Resultados. La sensibilidad y la especificidad en objetos, para reconocer cordones de tuberculosis fueron de 92,04% y de 94,93% respectivamente. La sensibilidad y la especificidad en foto, para determinar un campo positivo a tuberculoisis fueron 95,4% y de 98,07% respectivamente. Conclusiones. Los resultados demostraron la factibilidad de la implementación de telediagnóstico en lugares remotos, el cual puede contribuir con la detección temprana de tuberculosis multidrogorresistente mediante el método MODS

Mod i ledelse

DEFF Research Database (Denmark)

Mellon, Karsten

2016-01-01

Mod i ledelse er en efterspurgt vare i offentligt regi som modsvar på stigende kompleksitet og pres. Men hvad er ’mod i ledelse’ – og er du selv en modig leder?......Mod i ledelse er en efterspurgt vare i offentligt regi som modsvar på stigende kompleksitet og pres. Men hvad er ’mod i ledelse’ – og er du selv en modig leder?...

In-vitro antimycobacterial drug susceptibility testing of non-tubercular mycobacteria by tetrazolium microplate assay.

Science.gov (United States)

Sankar, Manimuthu Mani; Gopinath, Krishnamoorthy; Singla, Roopak; Singh, Sarman

2008-07-11

Non-tubercular mycobacteria (NTM) has not been given due attention till the recent epidemic of HIV. This has led to increasing interest of health care workers in their biology, epidemiology and drug resistance. However, timely detection and drug susceptibility profiling of NTM isolates are always difficult in resource poor settings like India. Furthermore, no standardized methodology or guidelines are available to reproduce the results with clinical concordance. To find an alternative and rapid method for performing the drug susceptibility assay in a resource limited settings like India, we intended to evaluate the utility of Tetrazolium microplate assay (TEMA) in comparison with proportion method for reporting the drug resistance in clinical isolates of NTM. A total of fifty-five NTM isolates were tested for susceptibility against Streptomycin, Rifampicin, Ethambutol, Ciprofloxacin, Ofloxacin, Azithromycin, and Clarithromycin by TEMA and the results were compared with agar proportion method (APM). Of the 55 isolates, 23 (41.8%) were sensitive to all the drugs and the remaining 32 (58.2%) were resistant to at least one drug. TEMA had very good concordance with APM except with minor discrepancies. Susceptibility results were obtained in the median of 5 to 9 days by TEMA. The NTM isolates were highly sensitive against Ofloxacin (98.18% sensitive) and Ciprofloxacin (90.09% sensitive). M. mucogenicum was sensitive only to Clarithromycin and resistant to all the other drugs tested. The concordance between TEMA and APM ranged between 96.4 - 100%. Tetrazolium Microplate Assay is a rapid and highly reproducible method. However, it must be performed only in tertiary level Mycobacteriology laboratories with proper bio-safety conditions.

Algebraic Structures on MOD Planes

OpenAIRE

Kandasamy, Vasantha; Ilanthenral, K.; Smarandache, Florentin

2015-01-01

Study of MOD planes happens to a very recent one. In this book, systematically algebraic structures on MOD planes like, MOD semigroups, MOD groups and MOD rings of different types are defined and studied. Such study is innovative for a large four quadrant planes are made into a small MOD planes. Several distinct features enjoyed by these MOD planes are defined, developed and described.

A dual reporter cell assay for identifying serotype and drug susceptibility of herpes simplex virus.

Science.gov (United States)

Lu, Wen-Wen; Sun, Jun-Ren; Wu, Szu-Sian; Lin, Wan-Hsuan; Kung, Szu-Hao

2011-08-15

A dual reporter cell assay (DRCA) that allows real-time detection of herpes simplex virus (HSV) infection was developed. This was achieved by stable transfection of cells with an expression cassette that contains the dual reporter genes, secreted alkaline phosphatase (SEAP) and enhanced green fluorescent protein (EGFP), under the control of an HSV early gene promoter. Baby hamster kidney (BHK) and Chinese hamster ovary (CHO) cell lines were used as parental cell lines because the former is permissive for both HSV serotypes, HSV-1 and HSV-2, whereas the latter is susceptible to infection only by HSV-2. The DRCA permitted differential detection of HSV-1 and HSV-2 by observation of EGFP-positive cells, as substantiated by screening a total of 35 samples. The BHK-based cell line is sensitive to a viral titer as low as a single plaque-forming unit with a robust assay window as measured by a chemiluminescent assay. Evaluations of the DRCA with representative acyclovir-sensitive and acyclovir-resistant HSV strains demonstrated that their drug susceptibilities were accurately determined by a 48-h format. In summary, this novel DRCA is a useful means for serotyping of HSV in real time as well as a rapid screening method for determining anti-HSV susceptibilities. Copyright © 2011 Elsevier Inc. All rights reserved.

Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: implications for gene regulation and virulence.

Science.gov (United States)

Tan, Aimee; Hill, Dorothea M C; Harrison, Odile B; Srikhanta, Yogitha N; Jennings, Michael P; Maiden, Martin C J; Seib, Kate L

2016-02-12

Neisseria meningitidis is a human-specific bacterium that varies in invasive potential. All meningococci are carried in the nasopharynx, and most genotypes are very infrequently associated with invasive meningococcal disease; however, those belonging to the 'hyperinvasive lineages' are more frequently associated with sepsis or meningitis. Genome content is highly conserved between carriage and disease isolates, and differential gene expression has been proposed as a major determinant of the hyperinvasive phenotype. Three phase variable DNA methyltransferases (ModA, ModB and ModD), which mediate epigenetic regulation of distinct phase variable regulons (phasevarions), have been identified in N. meningitidis. Each mod gene has distinct alleles, defined by their Mod DNA recognition domain, and these target and methylate different DNA sequences, thereby regulating distinct gene sets. Here 211 meningococcal carriage and >1,400 disease isolates were surveyed for the distribution of meningococcal mod alleles. While modA11-12 and modB1-2 were found in most isolates, rarer alleles (e.g., modA15, modB4, modD1-6) were specific to particular genotypes as defined by clonal complex. This suggests that phase variable Mod proteins may be associated with distinct phenotypes and hence invasive potential of N. meningitidis strains.

The detection and differentiation of methicillin-resistant and methicillin-susceptible Staphylococcus aureus endocarditis by using the BD GeneOhm StaphSR Assay.

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Frey, Amy B; Wilson, Deborah A; LaSalvia, Margaret M; Tan, Carmela D; Rodriguez, E Rene; Shrestha, Nabin K; Hall, Gerri S; Procop, Gary W

2011-11-01

We use the BD GeneOhm StaphSR Assay (BD Diagnostics, Oakville, Canada) to screen for Staphylococcus aureus nasal colonization and sought to evaluate this assay for the assessment of valve specimens from patients with endocarditis. We examined 23 paired fresh and formalin-fixed, paraffin-embedded cardiac valve tissue samples, 12 of which had S aureus endocarditis, using the BD GeneOhm StaphSR Assay for the detection and differentiation of methicillin-susceptible and methicillin-resistant S aureus. This assay appropriately characterized all specimens with respect to the presence or absence of S aureus. There was an 87.5% correlation between the presence or absence of the mecA gene and the oxacillin susceptibility results for the S aureus isolates studied. The GeneOhm StaphSR assay accurately detected S aureus in cardiac valve tissue samples. Rare discordances were observed between oxacillin susceptibility status and mecA gene detection by this assay.

A cell-based high-throughput screening assay for radiation susceptibility using automated cell counting

International Nuclear Information System (INIS)

Hodzic, Jasmina; Dingjan, Ilse; Maas, Mariëlle JP; Meulen-Muileman, Ida H van der; Menezes, Renee X de; Heukelom, Stan; Verheij, Marcel; Gerritsen, Winald R; Geldof, Albert A; Triest, Baukelien van; Beusechem, Victor W van

2015-01-01

Radiotherapy is one of the mainstays in the treatment for cancer, but its success can be limited due to inherent or acquired resistance. Mechanisms underlying radioresistance in various cancers are poorly understood and available radiosensitizers have shown only modest clinical benefit. There is thus a need to identify new targets and drugs for more effective sensitization of cancer cells to irradiation. Compound and RNA interference high-throughput screening technologies allow comprehensive enterprises to identify new agents and targets for radiosensitization. However, the gold standard assay to investigate radiosensitivity of cancer cells in vitro, the colony formation assay (CFA), is unsuitable for high-throughput screening. We developed a new high-throughput screening method for determining radiation susceptibility. Fast and uniform irradiation of batches up to 30 microplates was achieved using a Perspex container and a clinically employed linear accelerator. The readout was done by automated counting of fluorescently stained nuclei using the Acumen eX3 laser scanning cytometer. Assay performance was compared to that of the CFA and the CellTiter-Blue homogeneous uniform-well cell viability assay. The assay was validated in a whole-genome siRNA library screening setting using PC-3 prostate cancer cells. On 4 different cancer cell lines, the automated cell counting assay produced radiation dose response curves that followed a linear-quadratic equation and that exhibited a better correlation to the results of the CFA than did the cell viability assay. Moreover, the cell counting assay could be used to detect radiosensitization by silencing DNA-PKcs or by adding caffeine. In a high-throughput screening setting, using 4 Gy irradiated and control PC-3 cells, the effects of DNA-PKcs siRNA and non-targeting control siRNA could be clearly discriminated. We developed a simple assay for radiation susceptibility that can be used for high-throughput screening. This will aid

Expression, purification and DNA-binding activities of two putative ModE proteins of Herbaspirillum seropedicae (Burkholderiales, Oxalobacteraceae

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André L.F. Souza

2008-01-01

Full Text Available In prokaryotes molybdenum is taken up by a high-affinity ABC-type transporter system encoded by the modABC genes. The endophyte β-Proteobacterium Herbaspirillum seropedicae has two modABC gene clusters and two genes encoding putative Mo-dependent regulator proteins (ModE1 and ModE2. Analysis of the amino acid sequence of the ModE1 protein of H. seropedicae revealed the presence of an N-terminal domain containing a DNA-binding helix-turn-helix motif (HTH and a C-terminal domain with a molybdate-binding motif. The second putative regulator protein, ModE2, contains only the helix-turn-helix motif, similar to that observed in some sequenced genomes. We cloned the modE1 (810 bp and modE2 (372 bp genes and expressed them in Escherichia coli as His-tagged fusion proteins, which we subsequently purified. The over-expressed recombinant His-ModE1 was insoluble and was purified after solubilization with urea and then on-column refolded during affinity chromatography. The His-ModE2 was expressed as a soluble protein and purified by affinity chromatography. These purified proteins were analyzed by DNA band-shift assays using the modA2 promoter region as probe. Our results indicate that His-ModE1 and His-ModE2 are able to bind to the modA2 promoter region, suggesting that both proteins may play a role in the regulation of molybdenum uptake and metabolism in H. seropedicae.

Extension of the lod score: the mod score.

Science.gov (United States)

Clerget-Darpoux, F

2001-01-01

In 1955 Morton proposed the lod score method both for testing linkage between loci and for estimating the recombination fraction between them. If a disease is controlled by a gene at one of these loci, the lod score computation requires the prior specification of an underlying model that assigns the probabilities of genotypes from the observed phenotypes. To address the case of linkage studies for diseases with unknown mode of inheritance, we suggested (Clerget-Darpoux et al., 1986) extending the lod score function to a so-called mod score function. In this function, the variables are both the recombination fraction and the disease model parameters. Maximizing the mod score function over all these parameters amounts to maximizing the probability of marker data conditional on the disease status. Under the absence of linkage, the mod score conforms to a chi-square distribution, with extra degrees of freedom in comparison to the lod score function (MacLean et al., 1993). The mod score is asymptotically maximum for the true disease model (Clerget-Darpoux and Bonaïti-Pellié, 1992; Hodge and Elston, 1994). Consequently, the power to detect linkage through mod score will be highest when the space of models where the maximization is performed includes the true model. On the other hand, one must avoid overparametrization of the model space. For example, when the approach is applied to affected sibpairs, only two constrained disease model parameters should be used (Knapp et al., 1994) for the mod score maximization. It is also important to emphasize the existence of a strong correlation between the disease gene location and the disease model. Consequently, there is poor resolution of the location of the susceptibility locus when the disease model at this locus is unknown. Of course, this is true regardless of the statistics used. The mod score may also be applied in a candidate gene strategy to model the potential effect of this gene in the disease. Since, however, it

Molybdate transporter ModABC is important for Pseudomonas aeruginosa chronic lung infection.

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Périnet, Simone; Jeukens, Julie; Kukavica-Ibrulj, Irena; Ouellet, Myriam M; Charette, Steve J; Levesque, Roger C

2016-01-12

Mechanisms underlying the success of Pseudomonas aeruginosa in chronic lung infection among cystic fibrosis (CF) patients are poorly defined. The modA gene was previously linked to in vivo competitiveness of P. aeruginosa by a genetic screening in the rat lung. This gene encodes a subunit of transporter ModABC, which is responsible for extracellular uptake of molybdate. This compound is essential for molybdoenzymes, including nitrate reductases. Since anaerobic growth conditions are known to occur during CF chronic lung infection, inactivation of a molybdate transporter could inhibit proliferation through the inactivation of denitrification enzymes. Hence, we performed phenotypic characterization of a modA mutant strain obtained by signature-tagged mutagenesis (STM_modA) and assessed its virulence in vivo with two host models. The STM_modA mutant was in fact defective for anaerobic growth and unable to use nitrates in the growth medium for anaerobic respiration. Bacterial growth and nitrate usage were restored when the medium was supplemented with molybdate. Most significantly, the mutant strain showed reduced virulence compared to wild-type strain PAO1 according to a competitive index in the rat model of chronic lung infection and a predation assay with Dictyostelium discoideum amoebae. As the latter took place in aerobic conditions, the in vivo impact of the mutation in modA appears to extend beyond its effect on anaerobic growth. These results support the modABC-encoded transporter as important for the pathogenesis of P. aeruginosa, and suggest that enzymatic machinery implicated in anaerobic growth during chronic lung infection in CF merits further investigation as a potential target for therapeutic intervention.

TC-13 Mod 0 and Mod 2 Steam Catapult Test Site

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Federal Laboratory Consortium — Located on 11,000 feet of test runway, the TC-13 Mod 0 and Mod 2 Steam Catapult Test Site has in-ground catapults identical to those aboard carriers. This test site...

A rapid method for the determination of microbial susceptibility using the firefly luciferase assay for adenosine triphosphate (ATP)

Science.gov (United States)

Vellend, H.; Tuttle, S. A.; Barza, M.; Weinstein, L.; Picciolo, G. L.; Chappelle, E. W.

1975-01-01

Luciferase assay for adenosine triphosphate (ATP) was optimized for pure bacteria in broth in order to evaluate if changes in bacterial ATP content could be used as a rapid measure of antibiotic effect on microorganisms. Broth cultures of log phase bacteria were incubated at 310 K (37 C) for 2.5 hours at antimicrobial concentrations which resulted in the best discrimination between sensitive and resistant strains. Eighty-seven strains of 11 bacterial species were studied for their susceptibility to 12 commonly used antimicrobial agents: ampicillin, Penicillin G, nafcillin, carbenicillin, cephalothin, tetracycline, erythromycin, clindamycin, gentamicin, nitrofurantoin, colistin, and chloramplenicol. The major advantage of the ATP system over existing methods of rapid microbial susceptibility testing is that the assay can be made specific for bacterial ATP.

Functional characterization of the Bradyrhizobium japonicum modA and modB genes involved in molybdenum transport.

Science.gov (United States)

Delgado, María J; Tresierra-Ayala, Alvaro; Talbi, Chouhra; Bedmar, Eulogio J

2006-01-01

A modABC gene cluster that encodes an ABC-type, high-affinity molybdate transporter from Bradyrhizobium japonicum has been isolated and characterized. B. japonicum modA and modB mutant strains were unable to grow aerobically or anaerobically with nitrate as nitrogen source or as respiratory substrate, respectively, and lacked nitrate reductase activity. The nitrogen-fixing ability of the mod mutants in symbiotic association with soybean plants grown in a Mo-deficient mineral solution was severely impaired. Addition of molybdate to the bacterial growth medium or to the plant mineral solution fully restored the wild-type phenotype. Because the amount of molybdate required for suppression of the mutant phenotype either under free-living or under symbiotic conditions was dependent on sulphate concentration, it is likely that a sulphate transporter is also involved in Mo uptake in B. japonicum. The promoter region of the modABC genes has been characterized by primer extension. Reverse transcription and expression of a transcriptional fusion, P(modA)-lacZ, was detected only in a B. japonicum modA mutant grown in a medium without molybdate supplementation. These findings indicate that transcription of the B. japonicum modABC genes is repressed by molybdate.

Feasibility and cost analysis of programmatic implementation of ...

African Journals Online (AJOL)

Objectives: Detection of Multi-drug resistant tuberculosis in Nigeria still remains a challenge. We evaluated the feasibility of programmatic implementation of the Microscopic-Observation Drug Susceptibility (MODS) assay, a rapid culture and drug susceptibility testing technique for drug susceptibility testing in a low resource ...

An analysis of the binding of repressor protein ModE to modABCD (molybdate transport) operator/promoter DNA of Escherichia coli.

Science.gov (United States)

Grunden, A M; Self, W T; Villain, M; Blalock, J E; Shanmugam, K T

1999-08-20

Expression of the modABCD operon in Escherichia coli, which codes for a molybdate-specific transporter, is repressed by ModE in vivo in a molybdate-dependent fashion. In vitro DNase I-footprinting experiments identified three distinct regions of protection by ModE-molybdate on the modA operator/promoter DNA, GTTATATT (-15 to -8; region 1), GCCTACAT (-4 to +4; region 2), and GTTACAT (+8 to +14; region 3). Within the three regions of the protected DNA, a pentamer sequence, TAYAT (Y = C or T), can be identified. DNA-electrophoretic mobility experiments showed that the protected regions 1 and 2 are essential for binding of ModE-molybdate to DNA, whereas the protected region 3 increases the affinity of the DNA to the repressor. The stoichiometry of this interaction was found to be two ModE-molybdate per modA operator DNA. ModE-molybdate at 5 nM completely protected the modABCD operator/promoter DNA from DNase I-catalyzed hydrolysis, whereas ModE alone failed to protect the DNA even at 100 nM. The apparent K(d) for the interaction between the modA operator DNA and ModE-molybdate was 0.3 nM, and the K(d) increased to 8 nM in the absence of molybdate. Among the various oxyanions tested, only tungstate replaced molybdate in the repression of modA by ModE, but the affinity of ModE-tungstate for modABCD operator DNA was 6 times lower than with ModE-molybdate. A mutant ModE(T125I) protein, which repressed modA-lac even in the absence of molybdate, protected the same region of modA operator DNA in the absence of molybdate. The apparent K(d) for the interaction between modA operator DNA and ModE(T125I) was 3 nM in the presence of molybdate and 4 nM without molybdate. The binding of molybdate to ModE resulted in a decrease in fluorescence emission, indicating a conformational change of the protein upon molybdate binding. The fluorescence emission spectra of mutant ModE proteins, ModE(T125I) and ModE(Q216*), were unaffected by molybdate. The molybdate-independent mutant Mod

Who owns the mods?

OpenAIRE

Kow, Yong Ming; Nardi, Bonnie

2010-01-01

Modding, the development of end user software extensions to commercial products, is popular among video gamers. Modders form communities to help each other. Mods can shape software products by weaving in contributions from users themselves based on their own experience of a product. The purpose of this paper is to investigate a conflict between a modding community and a gaming company which reveals contested issues of ownership and governance. We studied an online game, World of Warcraft, a l...

Alcator C-Mod Tokamak

Data.gov (United States)

Federal Laboratory Consortium — Alcator C-Mod at the Massachusetts Institute of Technology is operated as a DOE national user facility. Alcator C-Mod is a unique, compact tokamak facility that uses...

Molybdate binding by ModA, the periplasmic component of the Escherichia coli mod molybdate transport system.

Science.gov (United States)

Imperial, J; Hadi, M; Amy, N K

1998-03-13

ModA, the periplasmic-binding protein of the Escherichia coli mod transport system was overexpressed and purified. Binding of molybdate and tungstate to ModA was found to modify the UV absorption and fluorescence emission spectra of the protein. Titration of these changes showed that ModA binds molybdate and tungstate in a 1:1 molar ratio. ModA showed an intrinsic fluorescence emission spectrum attributable to its three tryptophanyl residues. Molybdate binding caused a conformational change in the protein characterized by: (i) a shift of tryptophanyl groups to a more hydrophobic environment; (ii) a quenching (at pH 5.0) or enhancement (at pH 7.8) of fluorescence; and (iii) a higher availability of tryptophanyl groups to the polar quencher acrylamide. The tight binding of molybdate did not allow an accurate estimation of the binding constants by these indirect methods. An isotopic binding method with 99MoO42- was used for accurate determination of KD (20 nM) and stoichiometry (1:1 molar ratio). ModA bound tungstate with approximately the same affinity, but did not bind sulfate or phosphate. These KDs are 150- to 250-fold lower than those previously reported, and compatible with the high molybdate transport affinity of the mod system. The affinity of ModA for molybdate was also determined in vivo and found to be similar to that determined in vitro. Copyright 1998 Elsevier Science B.V.

Overexpression, purification, and partial characterization of ADP-ribosyltransferases modA and modB of bacteriophage T4.

Science.gov (United States)

Tiemann, B; Depping, R; Rüger, W

1999-01-01

There is increasing experimental evidence that ADP-ribosylation of host proteins is an important means to regulate gene expression of bacteriophage T4. Surprisingly, this phage codes for three different ADP-ribosyltransferases, gene products Alt, ModA, and ModB, modifying partially overlapping sets of host proteins. While gene product Alt already has been isolated as a recombinant protein and its action on host RNA polymerases and transcription regulation have been studied, the nucleotide sequences of the two mod genes was published only recently. Their mode of action in the course of the infection cycle and the consequences of the ADP-ribosylations catalyzed by these enzymes remain to be investigated. Here we describe the cloning of the genes, the overexpression, purification, and partial characterization of ADP-ribosyltransferases ModA and ModB. Both proteins seem to act independently, and the ADP-ribosyl moieties are transferred to different sets of host proteins. While gene product ModA, similarly to the Alt protein, acts also on the alpha-subunit of host RNA polymerase, the ModB activity serves another set of proteins, one of which was identified as the S1 protein associated with the 30S subunit of the E. coli ribosomes.

Assessment of RELAP5/MOD2 and RELAP5/MOD1-EUR codes on the basis of LOBI-MOD2 test results

International Nuclear Information System (INIS)

D'Auria, F.; Mazzini, M.; Oriolo, F.; Galassi, G.M.

1989-10-01

The present report deals with an overview of the application of RELAP5/MOD2 and RELAP5/MOD1-EUR codes to tests performed in the LOBI/MOD2 facility. The work has been carried out in the frame of a contract between Dipartimento di Costruzioni Meccaniche e Nucleari (DCMN) of Pisa University and CEC. The Universities of Roma, Pisa, Bologna and Palermo and the Polytechnic of Torino performed the post-test analysis of the LOBI experiment under the supervision of DCMN. In the report the main outcomes from the analysis of the LOBI experiments are given with the attempt to identify deficiencies in the modelling capabilities of the used codes

Binding and Oligomerization of Modified and Native Bt Toxins in Resistant and Susceptible Pink Bollworm.

Directory of Open Access Journals (Sweden)

Josue Ocelotl

Full Text Available Insecticidal proteins from Bacillus thuringiensis (Bt are used extensively in sprays and transgenic crops for pest control, but their efficacy is reduced when pests evolve resistance. Better understanding of the mode of action of Bt toxins and the mechanisms of insect resistance is needed to enhance the durability of these important alternatives to conventional insecticides. Mode of action models agree that binding of Bt toxins to midgut proteins such as cadherin is essential for toxicity, but some details remain unresolved, such as the role of toxin oligomers. In this study, we evaluated how Bt toxin Cry1Ac and its genetically engineered counterpart Cry1AcMod interact with brush border membrane vesicles (BBMV from resistant and susceptible larvae of Pectinophora gossypiella (pink bollworm, a global pest of cotton. Compared with Cry1Ac, Cry1AcMod lacks 56 amino acids at the amino-terminus including helix α-1; previous work showed that Cry1AcMod formed oligomers in vitro without cadherin and killed P. gossypiella larvae harboring cadherin mutations linked with >1000-fold resistance to Cry1Ac. Here we found that resistance to Cry1Ac was associated with reduced oligomer formation and insertion. In contrast, Cry1AcMod formed oligomers in BBMV from resistant larvae. These results confirm the role of cadherin in oligomerization of Cry1Ac in susceptible larvae and imply that forming oligomers without cadherin promotes toxicity of Cry1AcMod against resistant P. gossypiella larvae that have cadherin mutations.

RELAP5/MOD2 code assessment for the Semiscale Mod-2C Test S-LH-1

International Nuclear Information System (INIS)

Fineman, C.P.

1986-01-01

RELAP5/MOD2, Cycle 36.02, was assessed using data from Semiscale Mod-2C experiment S-LH-1. The major phenomena that occurred during the experiment were calculated by RELAP5/MOD2, although the duration and the magnitude of their effect on the transient were not always well calculated. Areas defined where further work was needed to improve the RELAP5 calculation include: (1) the system energy balance, (2) core interfacial drag, and 3) the heat transfer logic rod dryout criterion

R-HyMOD: an R-package for the hydrological model HyMOD

Science.gov (United States)

Baratti, Emanuele; Montanari, Alberto

2015-04-01

A software code for the implementation of the HyMOD hydrological model [1] is presented. HyMOD is a conceptual lumped rainfall-runoff model that is based on the probability-distributed soil storage capacity principle introduced by R. J. Moore 1985 [2]. The general idea behind this model is to describe the spatial variability of some process parameters as, for instance, the soil structure or the water storage capacities, through probability distribution functions. In HyMOD, the rainfall-runoff process is represented through a nonlinear tank connected with three identical linear tanks in parallel representing the surface flow and a slow-flow tank representing groundwater flow. The model requires the optimization of five parameters: Cmax (the maximum storage capacity within the watershed), β (the degree of spatial variability of the soil moisture capacity within the watershed), α (a factor for partitioning the flow between two series of tanks) and the two residence time parameters of quick-flow and slow-flow tanks, kquick and kslow respectively. Given its relatively simplicity but robustness, the model is widely used in the literature. The input data consist of precipitation and potential evapotranspiration at the given time scale. The R-HyMOD package is composed by a 'canonical' R-function of HyMOD and a fast FORTRAN implementation. The first one can be easily modified and can be used, for instance, for educational purposes; the second part combines the R user friendly interface with a fast processing unit. [1] Boyle D.P. (2000), Multicriteria calibration of hydrological models, Ph.D. dissertation, Dep. of Hydrol. and Water Resour., Univ of Arizona, Tucson. [2] Moore, R.J., (1985), The probability-distributed principle and runoff production at point and basin scale, Hydrol. Sci. J., 30(2), 273-297.

On mod 2 and higher elliptic genera

International Nuclear Information System (INIS)

Liu Kefeng

1992-01-01

In the first part of this paper, we construct mod 2 elliptic genera on manifolds of dimensions 8k+1, 8k+2 by mod 2 index formulas of Dirac operators. They are given by mod 2 modular forms or mod 2 automorphic functions. We also obtain an integral formula for the mod 2 index of the Dirac operator. As a by-product we find topological obstructions to group actions. In the second part, we construct higher elliptic genera and prove some of their rigidity properties under group actions. In the third part we write down characteristic series for all Witten genera by Jacobi theta-functions. The modular property and transformation formulas of elliptic genera then follow easily. We shall also prove that Krichever's genera, which come from integrable systems, can be written as indices of twisted Dirac operators for SU-manifolds. Some general discussions about elliptic genera are given. (orig.)

Analyzing pepsin degradation assay conditions used for allergenicity assessments to ensure that pepsin susceptible and pepsin resistant dietary proteins are distinguishable.

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Rong Wang

Full Text Available The susceptibility of a dietary protein to proteolytic degradation by digestive enzymes, such as gastric pepsin, provides information on the likelihood of systemic exposure to a structurally intact and biologically active macromolecule, thus informing on the safety of proteins for human and animal consumption. Therefore, the purpose of standardized in vitro degradation studies that are performed during protein safety assessments is to distinguish whether proteins of interest are susceptible or resistant to pepsin degradation via a study design that enables study-to-study comparison. Attempting to assess pepsin degradation under a wide-range of possible physiological conditions poses a problem because of the lack of robust and consistent data collected under a large-range of sub-optimal conditions, which undermines the needs to harmonize in vitro degradation conditions. This report systematically compares the effects of pH, incubation time, and pepsin-to-substrate protein ratio on the relative degradation of five dietary proteins: three pepsin susceptible proteins [ribulose 1,5-bisphosphate carboxylase-oxygenase (Rubisco, horseradish peroxidase (HRP, hemoglobin (Hb], and two pepsin resistant proteins [lipid transfer protein (LTP and soybean trypsin inhibitor (STI]. The results indicate that proteins susceptible to pepsin degradation are readily distinguishable from pepsin-resistant proteins when the reaction conditions are within the well-characterized optima for pepsin. The current standardized in vitro pepsin resistant assay with low pH and high pepsin-to-substrate ratio fits this purpose. Using non-optimal pH and/or pepsin-to-substrate protein ratios resulted in susceptible proteins no longer being reliably degraded by this stomach enzyme, which compromises the ability of this in vitro assay to distinguish between resistant and susceptible proteins and, therefore, no longer providing useful data to an overall weight-of-evidence approach to

RELAP5/MOD2 code assessment

International Nuclear Information System (INIS)

Nithianandan, C.K.; Shah, N.H.; Schomaker, R.J.; Miller, F.R.

1985-01-01

Babcock and Wilcox (B and W) has been working with the code developers at EG and G and the US Nuclear Regulatory Commission in assessing the RELAP5/MOD2 computer code for the past year by simulating selected separate-effects tests. The purpose of this assessment has been to evaluate the code for use in MIST (Ref. 2) and OTIS integral system tests simulations and in the prediction of pressurized water reactor transients. B and W evaluated various versions of the code and made recommendations to improve code performance. As a result, the currently released version (cycle 36.1) has been improved considerably over earlier versions. However, further refinements to some of the constitutive models may still be needed to further improve the predictive capability of RELAP5/MOD2. The following versions of the code were evaluated. (1) RELAP/MOD2/Cycle 22 - first released version; (2) YELAP5/Cycle 32 - EG and G test version of RELAP5/MOD2/Cycle 32; (3) RELAP5/MOD2/Cycle 36 - frozen cycle for international code assessment; (4) updates to cycle 36 based on recommendations developed by B and W during the simulation of a Massachusetts Institute of Technology (MIT) pressurizer test; and (5) cycle 36.1 updates received from EG and G

RELAP5/MOD2 code assessment

Energy Technology Data Exchange (ETDEWEB)

Nithianandan, C.K.; Shah, N.H.; Schomaker, R.J.; Miller, F.R.

1985-11-01

Babcock and Wilcox (B and W) has been working with the code developers at EG and G and the US Nuclear Regulatory Commission in assessing the RELAP5/MOD2 computer code for the past year by simulating selected separate-effects tests. The purpose of this assessment has been to evaluate the code for use in MIST (Ref. 2) and OTIS integral system tests simulations and in the prediction of pressurized water reactor transients. B and W evaluated various versions of the code and made recommendations to improve code performance. As a result, the currently released version (cycle 36.1) has been improved considerably over earlier versions. However, further refinements to some of the constitutive models may still be needed to further improve the predictive capability of RELAP5/MOD2. The following versions of the code were evaluated. (1) RELAP/MOD2/Cycle 22 - first released version; (2) YELAP5/Cycle 32 - EG and G test version of RELAP5/MOD2/Cycle 32; (3) RELAP5/MOD2/Cycle 36 - frozen cycle for international code assessment; (4) updates to cycle 36 based on recommendations developed by B and W during the simulation of a Massachusetts Institute of Technology (MIT) pressurizer test; and (5) cycle 36.1 updates received from EG and G.

Steady-state simulations of a 30-tube once-through steam generator with the RELAP5/MOD3 and RELAP5/MOD2 computer codes

International Nuclear Information System (INIS)

Hassan, Y.A.; Salim, P.

1991-01-01

This paper reports on a steady-state analysis of a 30-tube once-through steam generator that has been performed on the RELAPS/MOD3 and RELAPS/MOD2 computer codes for 100, 75, and 65% loads. Results obtained are compared with experimental data. The RELAP5/MOD3 results for the test facility generally agree reasonably well with the data for the primary-side temperature profiles. The secondary-side temperature profile predicted by RELAP5/MOD3 at 75 and 65% loads agrees fairly well with the data and is better than the RELAP5/MOD2 results. However, the RELAP5/MOD3 calculated secondary-side temperature profile does not compare well with the 100% load data

Post-test analysis of LOBI BT-01 using RELAP5/MOD2 and RELAP5/MOD3

International Nuclear Information System (INIS)

Holmes, B.J.

1991-08-01

LOBI is a high pressure, electrically heated integral system test facility simulating a KWU 1300 MW PWR scaled 1:712 by volume, although full scale has been maintained in the vertical direction. This report describes the results of an analysis of test BT-01, which simulates a 10% steam line break. The bulk of the analysis was performed using the Project Version of RELAP5/MOD2, with additional calculations using RELAP5/MOD3 for comparison. The codes provided generally good agreement with data. In particular, the break flows were well modelled, although the mass flow data proved to be unreliable, and this conclusion had to be derived from interpreting other signals. RELAP over-predicted primary/secondary heat transfer in the broken loop, however, leading to a more rapid cool-down of the primary circuit. Furthermore, the primary side pressure response was critically dependent upon the pressuriser behaviour, and the correct timing of the uncovery of the surge line. Inter-phase drag was not well predicted in the broken loop steam generator intermals, although some improvement was seen in the RELAP5/MOD3 predictions. MOD3 gave a reduction in primary/secondary heat transfer during the test pre-conditioning phase, resulting in a lower secondary side pressure at the start of the transient compared with MOD2. (author)

La Sémantique des Possibles Argumentatifs : un modèle de description-construction-représentation des significations lexicales

Directory of Open Access Journals (Sweden)

Virginie Marie

2009-12-01

Full Text Available Cet article se donne pour tâche d’illustrer le modèle théorique de la SPA (Sémantique des Possibles Argumentatifs proposé et développé par GALATANU. Cette théorie se présente comme un modèle de description de la signification lexicale susceptible de rendre compte aussi bien des représentations du monde perçu et « modélisé » par la langue que du « potentiel argumentatif » des mots, potentiel que l’environnement pragmatique de la phase énoncée et/ou l’environnement pragmatique (le contexte du discours peuvent activer, voire renforcer ou, au contraire, affaiblir, voire neutraliser ou même intervertir. Cette théorie s’inscrit dans la filiation de la sémantique argumentative (ANSCOMBRE, DUCROT, 1983, 1995 ; DUCROT, CAREL, 1999 et d’autre part, dans celle de la recherche sur les stéréotypes linguistiques (AMOSSY, 1994 ; KLEIBER, 1999a, b. Dans l’espace de cette communication nous nous proposons de présenter et d’appliquer ce modèle aux notions « francophile, francophilie, francophone, francophonie » qui rendra compte des déploiements argumentatifs en analysant l’évolution des définitions lexicographiques étudiées en termes de noyau et de stéréotypes.

CORCON-MOD1 modelling improvements

International Nuclear Information System (INIS)

Corradini, M.L.; Gonzales, F.G.; Vandervort, C.L.

1986-01-01

Given the unlikely occurrence of a severe accident in a light water reactor (LWR), the core may melt and slump into the reactor cavity below the reactor vessel. The interaction of the molten core with exposed concrete (a molten-core-concrete-interaction, MCCI) causes copious gas production which influences further heat transfer and concrete attack and may threaten containment integrity. In this paper the authors focus on the low-temperature phase of the MCCI where the molten pool is partially solidified, but is still capable of attacking concrete. The authors have developed some improved phenomenological models for pool freezing and molten core-coolant heat transfer and have incorporated them into the CORCON-MOD1 computer program. In the paper the authors compare the UW-CORCON/MOD1 calculations to CORCON/MOD2 and WECHSL results as well as the BETA experiments which are being conducted in Germany

TRAC-PF1/MOD2 status and plans

International Nuclear Information System (INIS)

Spore, J.W.; Steinke, R.G.; Nelson, R.A.; Cappiello, M.W.; Jenks, R.

1989-01-01

The development of the TRAC-PF1/MOD1 code was completed in July 1988 with the release of Version 14.4. A TRAC-PF1/MOD2 code development plan addresses code deficiencies identified in the MOD1 code in order to provide an accurate and defensible tool that can be used to simulate large-break loss-of-coolant accidents (LOCAs), small-break LOCAs, and operational transients. The MOD2 code development plan is an international cooperative effort that includes contributions from Los Alamos National Laboratory, Idaho National Engineering Laboratory (INEL), Japanese Atomic Energy Research Institute (JAERI), Cray Research, Central Electricity Generating Board (CEGB), and United Kingdom Atomic Energy Authority (UKAEA)

Estimating Fitness by Competition Assays between Drug Susceptible and Resistant Mycobacterium tuberculosis of Predominant Lineages in Mumbai, India

Science.gov (United States)

Bhatter, Purva; Chatterjee, Anirvan; D'souza, Desiree; Tolani, Monica; Mistry, Nerges

2012-01-01

Background Multi Drug Resistant Tuberculosis (MDR TB) is a threat to global tuberculosis control. A significant fitness cost has been associated with DR strains from specific lineages. Evaluation of the influence of the competing drug susceptible strains on fitness of drug resistant strains may have an important bearing on understanding the spread of MDR TB. The aim of this study was to evaluate the fitness of MDR TB strains, from a TB endemic region of western India: Mumbai, belonging to 3 predominant lineages namely CAS, Beijing and MANU in the presence of drug susceptible strains from the same lineages. Methodology Drug susceptible strains from a single lineage were mixed with drug resistant strain, bearing particular non synonymous mutation (rpoB D516V; inhA, A16G; katG, S315T1/T2) from the same or different lineages. Fitness of M.tuberculosis (M.tb) strains was evaluated using the difference in growth rates obtained by using the CFU assay system. Conclusion/Significance While MANU were most fit amongst the drug susceptible strains of the 3 lineages, only Beijing MDR strains were found to grow in the presence of any of the competing drug susceptible strains. A disproportionate increase in Beijing MDR could be an alarm for an impending epidemic in this locale. In addition to particular non synonymous substitutions, the competing strains in an environment may impact the fitness of circulating drug resistant strains. PMID:22479407

Simulation, modélisation et décision en pratique

CERN Document Server

Rennard, Jean-Philippe; Duymedjian, Raffi

2009-01-01

Avec l'explosion de la puissance informatique, le grand public dispose désormais d'outils aptes à résoudre des problèmes complexes, auparavant hors de portée des non-spécialistes. Le tableur notamment est particulièrement adapté à la modélisation et à la simulation de nombre de problèmes quotidiens de décision. En parallèle, le décideur est confronté à un environnement en évolution rapide, où la décision éclairée est une condition de succès. Face à une avalanche de données, il est le plus souvent amené à sélection intuitivement celles qui sont susceptibles de l'aide à anticiper les conséquences de ses décisions. Cet ouvrage se propose de présenter les principale méthodes d'aide à la décision et d'en montrer la mise en oeuvre avec le tableur. D'une difficulté progressive, l'ouvrage introduit à la modélisation e à la simulation pour la décision avant de présenter les outils dédiés à différents types de problèmes (prévision, optimisation, théorie des jeux, arbres d...

Rapid, low-cost fluorescent assay of β-lactamase-derived antibiotic resistance and related antibiotic susceptibility

Science.gov (United States)

Erdem, S. Sibel; Khan, Shazia; Palanisami, Akilan; Hasan, Tayyaba

2014-10-01

Antibiotic resistance (AR) is increasingly prevalent in low and middle income countries (LMICs), but the extent of the problem is poorly understood. This lack of knowledge is a critical deficiency, leaving local health authorities essentially blind to AR outbreaks and crippling their ability to provide effective treatment guidelines. The crux of the problem is the lack of microbiology laboratory capacity available in LMICs. To address this unmet need, we demonstrate a rapid and simple test of β-lactamase resistance (the most common form of AR) that uses a modified β-lactam structure decorated with two fluorophores quenched due to their close proximity. When the β-lactam core is cleaved by β-lactamase, the fluorophores dequench, allowing assay speeds of 20 min to be obtained with a simple, streamlined protocol. Furthermore, by testing in competition with antibiotics, the β-lactamase-associated antibiotic susceptibility can also be extracted. This assay can be easily implemented into standard lab work flows to provide near real-time information of β-lactamase resistance, both for epidemiological purposes as well as individualized patient care.

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

LENUS (Irish Health Repository)

Song, Yajun

2010-08-01

OBJECTIVES: Decreased susceptibility to fluoroquinolones has become a major problem for the successful therapy of human infections caused by Salmonella enterica, especially the life-threatening typhoid and paratyphoid fevers. METHODS: By using Luminex xTAG beads, we developed a rapid, reliable and cost-effective multiplexed genotyping assay for simultaneously detecting 11 mutations in gyrA, gyrB and parE of S. enterica serovars Typhi and Paratyphi A that result in nalidixic acid resistance (Nal(R)) and\\/or decreased susceptibility to fluoroquinolones. RESULTS: This assay yielded unambiguous single nucleotide polymorphism calls on extracted DNA from 292 isolates of Salmonella Typhi (Nal(R) = 223 and Nal(S) = 69) and 106 isolates of Salmonella Paratyphi A (Nal(R) = 24 and Nal(S) = 82). All of the 247 Nal(R) Salmonella Typhi and Salmonella Paratyphi A isolates were found to harbour at least one of the target mutations, with GyrA Phe-83 as the most common one (143\\/223 for Salmonella Typhi and 18\\/24 for Salmonella Paratyphi A). We also identified three GyrB mutations in eight Nal(S) Salmonella Typhi isolates (six for GyrB Phe-464, one for GyrB Leu-465 and one for GyrB Asp-466), and mutations GyrB Phe-464 and GyrB Asp-466 seem to be related to the decreased ciprofloxacin susceptibility phenotype in Salmonella Typhi. This assay can also be used directly on boiled single colonies. CONCLUSIONS: The assay presented here would be useful for clinical and reference laboratories to rapidly screen quinolone-resistant isolates of Salmonella Typhi and Salmonella Paratyphi A, and decipher the underlying genetic changes for epidemiological purposes.

NetMOD Version 2.0 User?s Manual.

Energy Technology Data Exchange (ETDEWEB)

Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-10-01

NetMOD ( Net work M onitoring for O ptimal D etection) is a Java-based software package for conducting simulation of seismic, hydracoustic, and infrasonic networks. Specifically, NetMOD simulates the detection capabilities of monitoring networks. Network simulations have long been used to study network resilience to station outages and to determine where additional stations are needed to reduce monitoring thresholds. NetMOD makes use of geophysical models to determine the source characteristics, signal attenuation along the path between the source and station, and the performance and noise properties of the station. These geophysical models are combined to simulate the relative amplitudes of signal and noise that are observed at each of the stations. From these signal-to-noise ratios (SNR), the probability of detection can be computed given a detection threshold. This manual describes how to configure and operate NetMOD to perform detection simulations. In addition, NetMOD is distributed with simulation datasets for the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) International Monitoring System (IMS) seismic, hydroacoustic, and infrasonic networks for the purpose of demonstrating NetMOD's capabilities and providing user training. The tutorial sections of this manual use this dataset when describing how to perform the steps involved when running a simulation. ACKNOWLEDGEMENTS We would like to thank the reviewers of this document for their contributions.

Comparison of SCDAP/RELAP5/MOD3 to TRAC-PF1/MOD1 for timing analysis of PWR fuel pin failures

International Nuclear Information System (INIS)

Jones, K.R.; Katsma, K.R.; Wade, N.L.; Siefken, L.J.; Straka, M.

1991-01-01

A comparison has been made of SCDAP/RELAP5/MOD3- and TRAC-PF1/MOD1- based calculations of the fuel pin failure timing (time from containment isolation signal to first fuel pin failure) in a loss-of-coolant accident (LOCA). The two codes were used to calculate the thermal-hydraulic boundary conditions for a complete, double-ended, offset-shear break of a cold leg in a Westinghouse 4-loop pressurized water reactor. Both calculations used the FRAPCON-2 code to calculate the steady-state fuel rod behavior and the FRAP-T6 code to calculate the transient fuel rod behavior. The analysis was performed for 16 combinations of fuel burnups and power peaking factors extending up to the Technical Specifications limits. While all calculations were made on a best-estimate basis, the SCDAP/RELAP5/MOD3 code has not yet been fully assessed for large-break LOCA analysis. The results indicate that SCDAP/RELAP5/MOD3 yields conservative fuel pin failure timing results in comparison to those generated using TRAC-PF1/MOD1. 7 refs., 5 figs

Alcator C-MOD proposal addendum

International Nuclear Information System (INIS)

Bonoli, P.; Greenwald, M.; Gwinn, D.

1986-04-01

Since the design concept and overall purpose of the Alcator C-MOD device are similar to that proposed in October 1985, we have chosen in this document only to highlight areas where changes or additions have been made. Chapters in the Addendum correspond to those in the Proposal, except Chapter 9 which describes a number of toroidal improvement concepts which are being considered for inclusion in the Alcator C-MOD experimental program. A description of the redesign and a discussion of the objectives of the experimental program are given

Apo and ligand-bound structures of ModA from the archaeon Methanosarcina acetivorans

International Nuclear Information System (INIS)

Chan, Sum; Giuroiu, Iulia; Chernishof, Irina; Sawaya, Michael R.; Chiang, Janet; Gunsalus, Robert P.; Arbing, Mark A.; Perry, L. Jeanne

2010-01-01

Crystal structures of ModA from M. acetivorans in the apo and ligand-bound conformations confirm domain rotation upon ligand binding. The trace-element oxyanion molybdate, which is required for the growth of many bacterial and archaeal species, is transported into the cell by an ATP-binding cassette (ABC) transporter superfamily uptake system called ModABC. ModABC consists of the ModA periplasmic solute-binding protein, the integral membrane-transport protein ModB and the ATP-binding and hydrolysis cassette protein ModC. In this study, X-ray crystal structures of ModA from the archaeon Methanosarcina acetivorans (MaModA) have been determined in the apoprotein conformation at 1.95 and 1.69 Å resolution and in the molybdate-bound conformation at 2.25 and 2.45 Å resolution. The overall domain structure of MaModA is similar to other ModA proteins in that it has a bilobal structure in which two mixed α/β domains are linked by a hinge region. The apo MaModA is the first unliganded archaeal ModA structure to be determined: it exhibits a deep cleft between the two domains and confirms that upon binding ligand one domain is rotated towards the other by a hinge-bending motion, which is consistent with the ‘Venus flytrap’ model seen for bacterial-type periplasmic binding proteins. In contrast to the bacterial ModA structures, which have tetrahedral coordination of their metal substrates, molybdate-bound MaModA employs octahedral coordination of its substrate like other archaeal ModA proteins

Bascule d'un modèle poutre à un modèle 3D en dynamique des machines tournantes

OpenAIRE

Tannous , Mikhael; Cartraud , Patrice; Dureisseix , David; Torkhani , Mohamed

2013-01-01

National audience; Les problèmes de machines tournantes incluant un contact rotor-stator, nécessitent un maillage 3D de la zone de contact. Cependant, un modèle 3D pour toute la durée de simulation conduit à des temps de calcul rédhibitoires. Or un modèle poutre est suffisant pour décrire la dynamique de la machine tournante hors contact. Une stratégie qui permet d'utiliser un modèle poutre et un autre 3D, pendant deux phases différentes durant la même simulation, permet donc de gagner en tem...

Apo and ligand-bound structures of ModA from the archaeon Methanosarcina acetivorans.

Science.gov (United States)

Chan, Sum; Giuroiu, Iulia; Chernishof, Irina; Sawaya, Michael R; Chiang, Janet; Gunsalus, Robert P; Arbing, Mark A; Perry, L Jeanne

2010-03-01

The trace-element oxyanion molybdate, which is required for the growth of many bacterial and archaeal species, is transported into the cell by an ATP-binding cassette (ABC) transporter superfamily uptake system called ModABC. ModABC consists of the ModA periplasmic solute-binding protein, the integral membrane-transport protein ModB and the ATP-binding and hydrolysis cassette protein ModC. In this study, X-ray crystal structures of ModA from the archaeon Methanosarcina acetivorans (MaModA) have been determined in the apoprotein conformation at 1.95 and 1.69 A resolution and in the molybdate-bound conformation at 2.25 and 2.45 A resolution. The overall domain structure of MaModA is similar to other ModA proteins in that it has a bilobal structure in which two mixed alpha/beta domains are linked by a hinge region. The apo MaModA is the first unliganded archaeal ModA structure to be determined: it exhibits a deep cleft between the two domains and confirms that upon binding ligand one domain is rotated towards the other by a hinge-bending motion, which is consistent with the 'Venus flytrap' model seen for bacterial-type periplasmic binding proteins. In contrast to the bacterial ModA structures, which have tetrahedral coordination of their metal substrates, molybdate-bound MaModA employs octahedral coordination of its substrate like other archaeal ModA proteins.

An Optimization Scheme for ProdMod

International Nuclear Information System (INIS)

Gregory, M.V.

1999-01-01

A general purpose dynamic optimization scheme has been devised in conjunction with the ProdMod simulator. The optimization scheme is suitable for the Savannah River Site (SRS) High Level Waste (HLW) complex operations, and able to handle different types of optimizations such as linear, nonlinear, etc. The optimization is performed in the stand-alone FORTRAN based optimization deliver, while the optimizer is interfaced with the ProdMod simulator for flow of information between the two

Conceptual design of the 7 megawatt Mod-5B wind turbine generator

Science.gov (United States)

Douglas, R. R.

1982-01-01

Similar to MOD-2, the MOD-5B wind turbine generator system is designed for the sole purpose of providing electrical power for distribution by a major utility network. The objectives of the MOD-2 and MOD-5B programs are essentially identical with one important exception; the cost-of-electricity (COE) target is reduced from 4 cent/Kwhr on MOD-2 to 3 cent/Kwhr on MOD-5B, based on mid 1977 dollars and large quantity production. The MOD-5B concept studies and eventual concept selection confirmed that the program COE targets could not only be achieved but substantially bettered. Starting from the established MOD-2 technology as a base, this achievement resulted from a combination of concept changes, size changes, and design refinements. The result of this effort is a wind turbine system that can compete with conventional power generation over significant geographical areas, increasing commercial market potential by an order of magnitude.

NetMOD version 1.0 user's manual

Energy Technology Data Exchange (ETDEWEB)

Merchant, Bion John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2014-01-01

NetMOD (Network Monitoring for Optimal Detection) is a Java-based software package for conducting simulation of seismic networks. Specifically, NetMOD simulates the detection capabilities of seismic monitoring networks. Network simulations have long been used to study network resilience to station outages and to determine where additional stations are needed to reduce monitoring thresholds. NetMOD makes use of geophysical models to determine the source characteristics, signal attenuation along the path between the source and station, and the performance and noise properties of the station. These geophysical models are combined to simulate the relative amplitudes of signal and noise that are observed at each of the stations. From these signal-to-noise ratios (SNR), the probability of detection can be computed given a detection threshold. This manual describes how to configure and operate NetMOD to perform seismic detection simulations. In addition, NetMOD is distributed with a simulation dataset for the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) International Monitoring System (IMS) seismic network for the purpose of demonstrating NetMOD's capabilities and providing user training. The tutorial sections of this manual use this dataset when describing how to perform the steps involved when running a simulation.

MOD silver metallization for photovoltaics

Science.gov (United States)

Vest, G. M.; Vest, R. W.

1984-01-01

The development of flat plate solar arrays is reported. Photovoltaic cells require back side metallization and a collector grid system on the front surface. Metallo-organic decomposition (MOD) silver films can eliminate most of the present problems with silver conductors. The objectives are to: (1) identify and characterize suitable MO compounds; (2) develop generic synthesis procedures for the MO compounds; (3) develop generic fabrication procedures to screen printable MOD silver inks; (4) optimize processing conditions to produce grid patterns and photovoltaic cells; and (5) develop a model which describes the adhesion between the fired silver film and the silicon surface.

NetMOD Version 2.0 Parameters

Energy Technology Data Exchange (ETDEWEB)

Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-08-01

NetMOD ( Net work M onitoring for O ptimal D etection) is a Java-based software package for conducting simulation of seismic, hydroacoustic and infrasonic networks. Network simulations have long been used to study network resilience to station outages and to determine where additional stations are needed to reduce monitoring thresholds. NetMOD makes use of geophysical models to determine the source characteristics, signal attenuation along the path between the source and station, and the performance and noise properties of the station. These geophysical models are combined to simulate the relative amplitudes of signal and noise that are observed at each of the stations. From these signal-to-noise ratios (SNR), the probability of detection can be computed given a detection threshold. This document describes the parameters that are used to configure the NetMOD tool and the input and output parameters that make up the simulation definitions.

RELAP5/MOD3 code coupling model

International Nuclear Information System (INIS)

Martin, R.P.; Johnsen, G.W.

1994-01-01

A new capability has been incorporated into RELAP5/MOD3 that enables the coupling of RELAP5/MOD3 to other computer codes. The new capability has been designed to support analysis of the new advanced reactor concepts. Its user features rely solely on new RELAP5 open-quotes styledclose quotes input and the Parallel Virtual Machine (PVM) software, which facilitates process management and distributed communication of multiprocess problems. RELAP5/MOD3 manages the input processing, communication instruction, process synchronization, and its own send and receive data processing. The flexible capability requires that an explicit coupling be established, which updates boundary conditions at discrete time intervals. Two test cases are presented that demonstrate the functionality, applicability, and issues involving use of this capability

Gas jet disruption mitigation studies on Alcator C-Mod

International Nuclear Information System (INIS)

Granetz, R.; Whyte, D.G.; Izzo, V.A.; Biewer, T.; Reinke, M.L.; Terry, J.; Bader, A.; Bakhtiari, M.; Jernigan, T.; Wurden, G.

2006-01-01

Damaging effects of disruptions are a major concern for Alcator C-Mod, ITER and future tokamak reactors. High-pressure noble gas jet injection is a mitigation technique which potentially satisfies the operational requirements of fast response time and reliability, while still being benign to subsequent discharges. Disruption mitigation experiments using an optimized gas jet injection system are being carried out on Alcator C-Mod to study the physics of gas jet penetration into high pressure plasmas, as well as the ability of the gas jet impurities to convert plasma energy into radiation on timescales consistent with C-Mod's fast quench times, and to reduce halo currents given C-Mod's high-current density. The dependence of impurity penetration and effectiveness on noble gas species (He, Ne, Ar, Kr) is also being studied. It is found that the high-pressure neutral gas jet does not penetrate deeply into the C-Mod plasma, and yet prompt core thermal quenches are observed on all gas jet shots. 3D MHD modelling of the disruption physics with NIMROD shows that edge cooling of the plasma triggers fast growing tearing modes which rapidly produce a stochastic region in the core of the plasma and loss of thermal energy. This may explain the apparent effectiveness of the gas jet in C-Mod despite its limited penetration. The higher-Z gases (Ne, Ar, Kr) also proved effective at reducing halo currents and decreasing thermal deposition to the divertor surfaces. In addition, noble gas jet injection proved to be benign for plasma operation with C-Mod's metal (Mo) wall, actually improving the reliability of the startup in the following discharge

VARSKIN MOD 2 and SADDE MOD2: Computer codes for assessing skin dose from skin contamination

International Nuclear Information System (INIS)

Durham, J.S.

1992-12-01

The computer code VARSKIN has been modified to calculate dose to skin from three-dimensional sources, sources separated from the skin by layers of protective clothing, and gamma dose from certain radionuclides correction for backscatter has also been incorporated for certain geometries. This document describes the new code, VARSKIN Mod 2, including installation and operation instructions, provides detailed descriptions of the models used, and suggests methods for avoiding misuse of the code. The input data file for VARSKIN Mod 2 has been modified to reflect current physical data, to include the contribution to dose from internal conversion and Auger electrons, and to reflect a correction for low-energy electrons. In addition, the computer code SADDE: Scaled Absorbed Dose Distribution Evaluator has been modified to allow the generation of scaled absorbed dose distributions for mixtures of radionuclides and intereat conversion and Auger electrons. This new code, SADDE Mod 2, is also described in this document. Instructions for installation and operation of the code and detailed descriptions of the models used in the code are provided

Implementation of the thermal-hydraulic transient analysis code RELAP4/MOD5 and MOD6 on the FACOM 230/75 computer system

International Nuclear Information System (INIS)

Kohsaka, Atsuo; Ishigai, Takahiro; Kumakura, Toshimasa; Naraoka, Ken-itsu

1979-03-01

Development efforts have continued on the extensively used LOCA analysis code RELAP-4, as seen in its history; that is, from the prototype version MOD2 to the latest one MOD6 which is capable of one-through calculations from blowdown to reflood phase of PWR-LOCA. Many improvements and refinements of the models have enlarged the scopes and extents of phenomena to treat. Correspondingly the size of program has increased version to version, and special programming techniques have continuously been introduced to manage the program within limited capacity of core memory. For example, the Dynamic Storage Allocation of MOD5 and the PRELOAD Preprocessor newly incorporated in MOD6 are those designed for the CDC computer with relatively small core size. Described are these programming techniques in detail and experiences on implementation of the codes on FACOM 230/75, together with some results of confirmatory calculations. (author)

Twenty Years of Research on the Alcator C-Mod Tokamak

Science.gov (United States)

Greenwald, Martin

2013-10-01

Alcator C-Mod is a compact, high-field tokamak, whose unique design and operating parameters have produced a wealth of new and important results since its start in 1993, contributing data that extended tests of critical physical models into new parameter ranges and into new regimes. Using only RF for heating and current drive with innovative launching structures, C-Mod operates routinely at very high power densities. Research highlights include direct experimental observation of ICRF mode-conversion, ICRF flow drive, demonstration of Lower-Hybrid current drive at ITER-like densities and fields and, using a set of powerful new diagnostics, extensive validation of advanced RF codes. C-Mod spearheaded the development of the vertical-target divertor and has always operated with high-Z metal plasma facing components--an approach adopted for ITER. C-Mod has made ground-breaking discoveries in divertor physics and plasma-material interactions at reactor-like power and particle fluxes and elucidated the critical role of cross-field transport in divertor operation, edge flows and the tokamak density limit. C-Mod developed the I-mode and EDA H-mode regimes which have high performance without large ELMs and with pedestal transport self-regulated by short-wavelength electromagnetic waves. C-Mod has carried out pioneering studies of intrinsic rotation and found that self-generated flow shear can be strong enough to significantly modify transport. C-Mod made the first quantitative link between pedestal temperature and H-mode performance, showing that the observed self-similar temperature profiles were consistent with critical-gradient-length theories and followed up with quantitative tests of nonlinear gyrokinetic models. Disruption studies on C-Mod provided the first observation of non-axisymmetric halo currents and non-axisymmetric radiation in mitigated disruptions. Work supported by U.S. DoE

NetMOD Version 2.0 Mathematical Framework

Energy Technology Data Exchange (ETDEWEB)

Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Young, Christopher J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Chael, Eric P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-08-01

NetMOD ( Net work M onitoring for O ptimal D etection) is a Java-based software package for conducting simulation of seismic, hydroacoustic and infrasonic networks. Network simulations have long been used to study network resilience to station outages and to determine where additional stations are needed to reduce monitoring thresholds. NetMOD makes use of geophysical models to determine the source characteristics, signal attenuation along the path between the source and station, and the performance and noise properties of the station. These geophysical models are combined to simulate the relative amplitudes of signal and noise that are observed at each of the stations. From these signal-to-noise ratios (SNR), the probabilities of signal detection at each station and event detection across the network of stations can be computed given a detection threshold. The purpose of this document is to clearly and comprehensively present the mathematical framework used by NetMOD, the software package developed by Sandia National Laboratories to assess the monitoring capability of ground-based sensor networks. Many of the NetMOD equations used for simulations are inherited from the NetSim network capability assessment package developed in the late 1980s by SAIC (Sereno et al., 1990).

Mod 1 ICS TI Report: ICS Conversion of a 140% HPGe Detector

Energy Technology Data Exchange (ETDEWEB)

Bounds, John Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-07-05

This report evaluates the Mod 1 ICS, an electrically cooled 140% HPGe detector. It is a custom version of the ORTEC Integrated Cooling System (ICS) modified to make it more practical for us to use in the field. Performance and operating characteristics of the Mod 1 ICS are documented, noting both pros and cons. The Mod 1 ICS is deemed a success. Recommendations for a Mod 2 ICS, a true field prototype, are provided.

20 years of research on the Alcator C-Mod tokamaka)

Science.gov (United States)

Greenwald, M.; Bader, A.; Baek, S.; Bakhtiari, M.; Barnard, H.; Beck, W.; Bergerson, W.; Bespamyatnov, I.; Bonoli, P.; Brower, D.; Brunner, D.; Burke, W.; Candy, J.; Churchill, M.; Cziegler, I.; Diallo, A.; Dominguez, A.; Duval, B.; Edlund, E.; Ennever, P.; Ernst, D.; Faust, I.; Fiore, C.; Fredian, T.; Garcia, O.; Gao, C.; Goetz, J.; Golfinopoulos, T.; Granetz, R.; Grulke, O.; Hartwig, Z.; Horne, S.; Howard, N.; Hubbard, A.; Hughes, J.; Hutchinson, I.; Irby, J.; Izzo, V.; Kessel, C.; LaBombard, B.; Lau, C.; Li, C.; Lin, Y.; Lipschultz, B.; Loarte, A.; Marmar, E.; Mazurenko, A.; McCracken, G.; McDermott, R.; Meneghini, O.; Mikkelsen, D.; Mossessian, D.; Mumgaard, R.; Myra, J.; Nelson-Melby, E.; Ochoukov, R.; Olynyk, G.; Parker, R.; Pitcher, S.; Podpaly, Y.; Porkolab, M.; Reinke, M.; Rice, J.; Rowan, W.; Schmidt, A.; Scott, S.; Shiraiwa, S.; Sierchio, J.; Smick, N.; Snipes, J. A.; Snyder, P.; Sorbom, B.; Stillerman, J.; Sung, C.; Takase, Y.; Tang, V.; Terry, J.; Terry, D.; Theiler, C.; Tronchin-James, A.; Tsujii, N.; Vieira, R.; Walk, J.; Wallace, G.; White, A.; Whyte, D.; Wilson, J.; Wolfe, S.; Wright, G.; Wright, J.; Wukitch, S.; Zweben, S.

2014-11-01

The object of this review is to summarize the achievements of research on the Alcator C-Mod tokamak [Hutchinson et al., Phys. Plasmas 1, 1511 (1994) and Marmar, Fusion Sci. Technol. 51, 261 (2007)] and to place that research in the context of the quest for practical fusion energy. C-Mod is a compact, high-field tokamak, whose unique design and operating parameters have produced a wealth of new and important results since it began operation in 1993, contributing data that extends tests of critical physical models into new parameter ranges and into new regimes. Using only high-power radio frequency (RF) waves for heating and current drive with innovative launching structures, C-Mod operates routinely at reactor level power densities and achieves plasma pressures higher than any other toroidal confinement device. C-Mod spearheaded the development of the vertical-target divertor and has always operated with high-Z metal plasma facing components—approaches subsequently adopted for ITER. C-Mod has made ground-breaking discoveries in divertor physics and plasma-material interactions at reactor-like power and particle fluxes and elucidated the critical role of cross-field transport in divertor operation, edge flows and the tokamak density limit. C-Mod developed the I-mode and the Enhanced Dα H-mode regimes, which have high performance without large edge localized modes and with pedestal transport self-regulated by short-wavelength electromagnetic waves. C-Mod has carried out pioneering studies of intrinsic rotation and demonstrated that self-generated flow shear can be strong enough in some cases to significantly modify transport. C-Mod made the first quantitative link between the pedestal temperature and the H-mode's performance, showing that the observed self-similar temperature profiles were consistent with critical-gradient-length theories and followed up with quantitative tests of nonlinear gyrokinetic models. RF research highlights include direct experimental

Hot particle dose calculations using the computer code VARSKIN Mod 2

International Nuclear Information System (INIS)

Durham, J.S.

1991-01-01

The only calculational model recognised by the Nuclear Regulatory Commission (NRC) for hot particle dosimetry is VARSKIN Mod 1. Because the code was designed to calculate skin dose from distributed skin contamination and not hot particles, it is assumed that the particle has no thickness and, therefore, that no self-absorption occurs within the source material. For low energy beta particles such as those emitted from 60 Co, a significant amount of self-shielding occurs in hot particles and VARSKIN Mod 1 overestimates the skin dose. In addition, the presence of protective clothing, which will reduce the calculated skin dose for both high and low energy beta emitters, is not modelled in VARSKIN Mod 1. Finally, there is no provision in VARSKIN Mod 1 to calculate the gamma contribution to skin dose from radionuclides that emit both beta and gamma radiation. The computer code VARSKIN Mod 1 has been modified to model three-dimensional sources, insertion of layers of protective clothing between the source and skin, and gamma dose from appropriate radionuclides. The new code, VARSKIN Mod 2, is described and the sensitivity of the calculated dose to source geometry, diameter, thickness, density, and protective clothing thickness are discussed. Finally, doses calculated using VARSKIN Mod 2 are compared to doses measured from hot particles found in nuclear power plants. (author)

Teaching Mods with Class

DEFF Research Database (Denmark)

Champion, Erik

2012-01-01

from around the world, representing fields as diverse as architecture, ethnography, puppetry, cultural studies, music education, interaction design and industrial design. How can we design, play with and reflect on the contribution of game mods, related tools and techniques, to both game studies...

NAUA Mod 4

International Nuclear Information System (INIS)

Bunz, H.; Koyro, M.; Schoeck, W.

1983-08-01

This report describes the computer program NAUA Mod4. Its purpose is to calculate the behaviour of a polydisperse aerosol system in a closed vessel containing a condensing atmosphere as a function of the time. The main object is to explain the physical background and to describe the structure of the code and the input and output in detail. (orig.) [de

Developmental assessment of RELAP5/MOD3 using the semiscale natural circulation tests

International Nuclear Information System (INIS)

Carlson, K.E.

1990-01-01

A code development effort creating RELAP5/MOD3 from RELAP5/MOD2 has been completed. Upon completion, a developmental assessment task was performed. One of the problems used for the developmental assessment was the Semiscale Natural Circulation Test. Calculated results from RELAP5/MOD3 are compared to measured data and previously calculated results from RELAP5/MOD2. 10 refs., 6 figs., 1 tab

A fast, simple method for screening radiation susceptibility genes by RNA interference

International Nuclear Information System (INIS)

Tsuji, Atsushi B.; Sudo, Hitomi; Sugyo, Aya; Otsuki, Marika; Miyagishi, Makoto; Taira, Kazunari; Imai, Takashi; Harada, Yoshi-nobu

2005-01-01

Radiotherapy can cause unacceptable levels of damage to normal tissues in some cancer patients. To understand the molecular mechanisms underlying radiation-induced physiological responses, and to be able to predict the radiation susceptibility of normal tissues in individual patients, it is important to identify a comprehensive set of genes responsible for radiation susceptibility. We have developed a simple and rapid 96-well screening protocol using cell proliferation assays and RNA interference to identify genes associated with radiation susceptibility. We evaluated the performance of alamarBlue-, BrdU-, and sulforhodamine B-based cell proliferation assays using the 96-well format. Each proliferation assay detected the known radiation susceptibility gene, PRKDC. In a trial screen using 28 shRNA vectors, another known gene, CDKN1A, and one new radiation susceptibility gene, ATP5G3, were identified. Our results indicate that this method may be useful for large-scale screens designed to identify novel radiation susceptibility genes

Københavns Kommunes indsats mod social dumping - målopfyldelsesevaluering

DEFF Research Database (Denmark)

Baadsgaard, Kelvin; Jørgensen, Henning

2016-01-01

Evaluering af, om de politiske intentioner med indsats mod social dumping i Københavns Kommune er blevet indfriet......Evaluering af, om de politiske intentioner med indsats mod social dumping i Københavns Kommune er blevet indfriet...

RELAP5/MOD3 AP600 problems

International Nuclear Information System (INIS)

Riemke, R.A.

1993-01-01

RELAP5/MOD3 is a reactor systems analysis code that has been developed jointly by the US Nuclear Regulatory Commission (USNRC) and a consortium consisting of several of the countries and domestic organizations that were members of the International Code Assessment and Applications Program (ICAP). The code is currently being used to simulate transients for the next generation of advanced light water reactors (ALWR's). One particular reactor design is the Westinghouse AP600 pressurized water reactor (PWR), which consists of two hot legs and four cold legs as well as passive emergency core cooling (ECC) systems. Initial calculations with RELAP5/MOD3 indicated that the code was not as robust as RELAP5/MOD2.5 with regard to AP600 calculations. Recent modifications in the areas of condensation wall heat transfer, interfacial heat transfer in the presence of noncondensibles, bubbly flow interfacial heat transfer, and time smoothing of both interfacial drag and interfacial heat transfer have improved the robustness, although more reliability is needed

20 years of research on the Alcator C-Mod tokamak

International Nuclear Information System (INIS)

Greenwald, M.; Baek, S.; Barnard, H.; Beck, W.; Bonoli, P.; Brunner, D.; Burke, W.; Ennever, P.; Ernst, D.; Faust, I.; Fiore, C.; Fredian, T.; Gao, C.; Golfinopoulos, T.; Granetz, R.; Hartwig, Z.; Hubbard, A.; Hughes, J.; Hutchinson, I.; Irby, J.

2014-01-01

The object of this review is to summarize the achievements of research on the Alcator C-Mod tokamak [Hutchinson et al., Phys. Plasmas 1, 1511 (1994) and Marmar, Fusion Sci. Technol. 51, 261 (2007)] and to place that research in the context of the quest for practical fusion energy. C-Mod is a compact, high-field tokamak, whose unique design and operating parameters have produced a wealth of new and important results since it began operation in 1993, contributing data that extends tests of critical physical models into new parameter ranges and into new regimes. Using only high-power radio frequency (RF) waves for heating and current drive with innovative launching structures, C-Mod operates routinely at reactor level power densities and achieves plasma pressures higher than any other toroidal confinement device. C-Mod spearheaded the development of the vertical-target divertor and has always operated with high-Z metal plasma facing components—approaches subsequently adopted for ITER. C-Mod has made ground-breaking discoveries in divertor physics and plasma-material interactions at reactor-like power and particle fluxes and elucidated the critical role of cross-field transport in divertor operation, edge flows and the tokamak density limit. C-Mod developed the I-mode and the Enhanced Dα H-mode regimes, which have high performance without large edge localized modes and with pedestal transport self-regulated by short-wavelength electromagnetic waves. C-Mod has carried out pioneering studies of intrinsic rotation and demonstrated that self-generated flow shear can be strong enough in some cases to significantly modify transport. C-Mod made the first quantitative link between the pedestal temperature and the H-mode's performance, showing that the observed self-similar temperature profiles were consistent with critical-gradient-length theories and followed up with quantitative tests of nonlinear gyrokinetic models. RF research highlights include direct experimental

Vaccine mod halthed testes i besætning

DEFF Research Database (Denmark)

Lauritsen, Klara Tølbøll

2012-01-01

Ny vaccine mod ledbetændelse forårsaget af Mycoplasma hyosynoviae testes nu hos 200 svin i en problembesætning. Håbet er færre halte svin og en nedbringelse af antibiotikaforbruget.......Ny vaccine mod ledbetændelse forårsaget af Mycoplasma hyosynoviae testes nu hos 200 svin i en problembesætning. Håbet er færre halte svin og en nedbringelse af antibiotikaforbruget....

Functional overview of the Production Planning Model (ProdMod)

International Nuclear Information System (INIS)

Gregory, M.V.; Paul, P.K.

1995-09-01

The Production Planning Model (ProdMod) has been developed by SRTC for use by High Level Waste Program Management and High Level Waste Engineering as a fast running, integrated, comprehensive model of the entire SRS high level waste (HLW) complex. ProdMod can simulate the response of the HLW complex from its current state to the end of tank clean-up or to any intermediate point. The present document describes the initial release of ProdMod at the end of FY95: a model version that contains all the significant elements from the High-level Waste System Plan Revision 5 and is capable of running the simulation all the way to the postulated completion of waste removal. For the scenario represented by this release, that simulates approximately 70 years of operation of the HLW complex (out to FY2065). This initial release of ProdMod will serve as the immediate starting point for the modeling of the High-Level Waste System Plan Revision 6. Thus ProdMod is expected to be in a state of continuous change and improvement.the initial goal has been to generate a simulation of the processes of interest, with the emphasis on mass and volume balances tracked throughout the HLW complex. That has been accomplished. Future development will add a set of cost equations to the process equations and extend the model for use as a linear programming (optimization) application. The goal of this later phase will be to free the ProdMod user to some extent from the need to set up detailed simulation scenarios: the model will automatically make operational choices which minimize or maximize a given objective function. Appendix A contains the source code

Comparision of calculations for the ROSA-IV LSTF with RELAP5/MOD0 and RELAP5/MOD1 (cycle 1)

International Nuclear Information System (INIS)

Fineman, C.P.; Tanaka, Mitsugu; Tasaka, Kanji

1982-03-01

10% and 2.5% cold leg break analyses have been completed for the ROSA-IV Large Scale Test Facility (LSTF) with the RELAP5/MOD0 and RELAP5/MOD1, cycle 1, computer codes. Comparisons between the calculations were made to determine any differences in the results obtained from the two versions of RELAP5. Differences in the two calculations were found which can be attributed to changes in the flow regime maps and critical flow model. (author)

Cloud-based uniform ChIP-Seq processing tools for modENCODE and ENCODE.

Science.gov (United States)

Trinh, Quang M; Jen, Fei-Yang Arthur; Zhou, Ziru; Chu, Kar Ming; Perry, Marc D; Kephart, Ellen T; Contrino, Sergio; Ruzanov, Peter; Stein, Lincoln D

2013-07-22

Funded by the National Institutes of Health (NIH), the aim of the Model Organism ENCyclopedia of DNA Elements (modENCODE) project is to provide the biological research community with a comprehensive encyclopedia of functional genomic elements for both model organisms C. elegans (worm) and D. melanogaster (fly). With a total size of just under 10 terabytes of data collected and released to the public, one of the challenges faced by researchers is to extract biologically meaningful knowledge from this large data set. While the basic quality control, pre-processing, and analysis of the data has already been performed by members of the modENCODE consortium, many researchers will wish to reinterpret the data set using modifications and enhancements of the original protocols, or combine modENCODE data with other data sets. Unfortunately this can be a time consuming and logistically challenging proposition. In recognition of this challenge, the modENCODE DCC has released uniform computing resources for analyzing modENCODE data on Galaxy (https://github.com/modENCODE-DCC/Galaxy), on the public Amazon Cloud (http://aws.amazon.com), and on the private Bionimbus Cloud for genomic research (http://www.bionimbus.org). In particular, we have released Galaxy workflows for interpreting ChIP-seq data which use the same quality control (QC) and peak calling standards adopted by the modENCODE and ENCODE communities. For convenience of use, we have created Amazon and Bionimbus Cloud machine images containing Galaxy along with all the modENCODE data, software and other dependencies. Using these resources provides a framework for running consistent and reproducible analyses on modENCODE data, ultimately allowing researchers to use more of their time using modENCODE data, and less time moving it around.

Modding a free and open source software video game: "Play testing is hard work"

Directory of Open Access Journals (Sweden)

Giacomo Poderi

2014-03-01

Full Text Available Video game modding is a form of fan productivity in contemporary participatory culture. We see modding as an important way in which modders experience and conceptualize their work. By focusing on modding in a free and open source software video game, we analyze the practice of modding and the way it changes modders' relationship with their object of interest. The modders' involvement is not always associated with fun and creativity. Indeed, activities such as play testing often undermine these dimensions of modding. We present a case study of modding that is based on ethnographic research done for The Battle for Wesnoth, a free and open source software strategy video game entirely developed by a community of volunteers.

Ny vaccine mod ledbetændelse er ikke effektiv

DEFF Research Database (Denmark)

Nielsen, Elisabeth Okholm; Lauritsen, Klara Tølbøll

2013-01-01

En ny mulighed for at vaccinere mod mykoplasma-ledbetændelse er undersøgt hos en slagtesvineproducent. Vaccinen kunne desværre ikke forebygge halthed eff ektivt.......En ny mulighed for at vaccinere mod mykoplasma-ledbetændelse er undersøgt hos en slagtesvineproducent. Vaccinen kunne desværre ikke forebygge halthed eff ektivt....

Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni.

Directory of Open Access Journals (Sweden)

Sandra D Melman

2009-08-01

Full Text Available The near exclusive use of praziquantel (PZQ for treatment of human schistosomiasis has raised concerns about the possible emergence of drug-resistant schistosomes.We measured susceptibility to PZQ of isolates of Schistosoma mansoni obtained from patients from Kisumu, Kenya continuously exposed to infection as a consequence of their occupations as car washers or sand harvesters. We used a an in vitro assay with miracidia, b an in vivo assay targeting adult worms in mice and c an in vitro assay targeting adult schistosomes perfused from mice. In the miracidia assay, in which miracidia from human patients were exposed to PZQ in vitro, reduced susceptibility was associated with previous treatment of the patient with PZQ. One isolate ("KCW" that was less susceptible to PZQ and had been derived from a patient who had never fully cured despite multiple treatments was studied further. In an in vivo assay of adult worms, the KCW isolate was significantly less susceptible to PZQ than two other isolates from natural infections in Kenya and two lab-reared strains of S. mansoni. The in vitro adult assay, based on measuring length changes of adults following exposure to and recovery from PZQ, confirmed that the KCW isolate was less susceptible to PZQ than the other isolates tested. A sub-isolate of KCW maintained separately and tested after three years was susceptible to PZQ, indicative that the trait of reduced sensitivity could be lost if selection was not maintained.Isolates of S. mansoni from some patients in Kisumu have lower susceptibility to PZQ, including one from a patient who was never fully cured after repeated rounds of treatment administered over several years. As use of PZQ continues, continued selection for worms with diminished susceptibility is possible, and the probability of emergence of resistance will increase as large reservoirs of untreated worms diminish. The potential for rapid emergence of resistance should be an important

SCDAP/RELAP5/MOD3 code development and assessment

International Nuclear Information System (INIS)

Allison, C.M.; Heath, C.H.; Siefken, L.J.; Hohorst, J.K.

1991-01-01

The SCDAP/RELAP5/MOD3 computer code is designed to describe the overall reactor coolant system (RCS) thermal-hydraulic response, core damage progression, and fission product release and transport during severe accidents. The code is being developed at the Idaho National Engineering Laboratory (INEL) under the primary sponsorship of the Office of Nuclear Regulatory Research of the Nuclear Regulatory Commission (NRC). SCDAP/RELAP5/MOD3, created in January, 1991, is the result of merging RELAP5/MOD3 with SCDAP and TRAP-MELT models from SCDAP/RELAP5/MOD2.5. The RELAP5 models calculate the overall RCS thermal-hydraulics, control system interactions, reactor kinetics, and the transport of noncondensible gases, fission products, and aerosols. The SCDAP models calculate the damage progression in the core structures, the formation, heatup, and melting of debris, and the creep rupture failure of the lower head and other RCS structures. The TRAP-MELT models calculate the deposition of fission products upon aerosols or structural surfaces; the formation, growth, or deposition of aerosols; and the evaporation of species from surfaces. The systematic assessment of modeling uncertainties in SCDAP/RELAP5 code is currently underway. This assessment includes (a) the evaluation of code-to-data comparisons using stand-alone SCDAP and SCDAP/RELAP5/MOD3, (b) the estimation of modeling and experimental uncertainties, and (c) the determination of the influence of those uncertainties on predicted severe accident behavior

GeoMod 2014 - Modelling in geoscience

Science.gov (United States)

Leever, Karen; Oncken, Onno

2016-08-01

GeoMod is a biennial conference to review and discuss latest developments in analogue and numerical modelling of lithospheric and mantle deformation. GeoMod2014 took place at the GFZ German Research Centre for Geosciences in Potsdam, Germany. Its focus was on rheology and deformation at a wide range of temporal and spatial scales: from earthquakes to long-term deformation, from micro-structures to orogens and subduction systems. It also addressed volcanotectonics and the interaction between tectonics and surface processes (Elger et al., 2014). The conference was followed by a 2-day short course on "Constitutive Laws: from Observation to Implementation in Models" and a 1-day hands-on tutorial on the ASPECT numerical modelling software.

Assessment and improvement of condensation models in RELAP5/MOD3.2

Energy Technology Data Exchange (ETDEWEB)

Choi, Ki Yong; Park, Hyun Sik; Kim, Sang Jae; No, Hee Chen [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1998-12-31

The condensation models in the standard RELAP5/MOD3.2 code are assessed and improved based on the database, which is constructed from the previous experimental data on various condensation phenomena. The default model of the laminar film condensation in RELAP5/MOD3.2 does not give any reliable predictions, and its alternative model always predicts higher values than the experimental data. Therefore, it is needed to develop a new correlation based on the experimental data of various operating ranges in the constructed database. The Shah correlation, which is used to calculate the turbulent film condensation heat transfer coefficients in the standard RELAP5/MOD3.2, well predicts the experimental data in the database. The horizontally stratified condensation model of RELAP5/MOD3.2 overpredicts both cocurrent and countercurrent experimental data. The correlation proposed by H.J.Kim predicts the database relatively well compared with that of RELAP6/MOD3.2. The RELAP5/MOD3.2 model should use the liquid velocity for the calculation of the liquid Reynolds number and be modified to consider the effects of the gas velocity and the film thickness. 2 refs., 5 figs., 1 tab. (Author)

Assessment and improvement of condensation models in RELAP5/MOD3.2

Energy Technology Data Exchange (ETDEWEB)

Choi, Ki Yong; Park, Hyun Sik; Kim, Sang Jae; No, Hee Chen [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1997-12-31

The condensation models in the standard RELAP5/MOD3.2 code are assessed and improved based on the database, which is constructed from the previous experimental data on various condensation phenomena. The default model of the laminar film condensation in RELAP5/MOD3.2 does not give any reliable predictions, and its alternative model always predicts higher values than the experimental data. Therefore, it is needed to develop a new correlation based on the experimental data of various operating ranges in the constructed database. The Shah correlation, which is used to calculate the turbulent film condensation heat transfer coefficients in the standard RELAP5/MOD3.2, well predicts the experimental data in the database. The horizontally stratified condensation model of RELAP5/MOD3.2 overpredicts both cocurrent and countercurrent experimental data. The correlation proposed by H.J.Kim predicts the database relatively well compared with that of RELAP6/MOD3.2. The RELAP5/MOD3.2 model should use the liquid velocity for the calculation of the liquid Reynolds number and be modified to consider the effects of the gas velocity and the film thickness. 2 refs., 5 figs., 1 tab. (Author)

Prevalence and Antibiotic susceptibility pattern of Panton-Valentine ...

African Journals Online (AJOL)

Staphylococcal cassette chromosome mec typing by two standard multiplex PCR assay, revealed an uncharacterized resistance element. Overall antibiotic susceptibility pattern showed relatively high degree of susceptibility,however 1 isolate demostrated multidrug resistant pattern, 37(74.0%)resistant to only penicillin, 5 to ...

Using computer program RELAP5/MOD2 on microcomputers

International Nuclear Information System (INIS)

Grgic, D.; Bajs, T; Cavlina, N.; Debrecin, N.

1990-01-01

Our work on installation of RELAP5/MOD2 code on IBM4341, mVAX 11, MGT-386 and COMPAQ-386/20e computers is described. Main characteristics of RELAP5/MOD2 structure programming style and differences between FORTRAN VS, VAX-11 FORTRAN and NDP FORTRAN 386 are presented. We discussed basic philosophy used in modification and testing and test results. (author)

Characterization of the Hamamatsu 8" R5912-MOD Photomultiplier tube

Science.gov (United States)

Kaptanoglu, Tanner

2018-05-01

Current and future neutrino and direct detection dark matter experiments hope to take advantage of improving technologies in photon detection. Many of these detectors are large, monolithic optical detectors that use relatively low-cost, large-area, and efficient photomultiplier tubes (PMTs). A candidate PMT for future experiments is a newly developed prototype Hamamatsu PMT, the R5912-MOD. In this paper we describe measurements made of the single photoelectron time and charge response of the R5912-MOD, as well as detail some direct comparisons to similar PMTs. Most of these measurements were performed on three R5912-MOD PMTs operating at gains close to 1 × 107. The transit time spread (σ) and the charge peak-to-valley were measured to be on average 680ps and 4.2 respectively. The results of this paper show the R5912-MOD is an excellent candidate for future experiments in several regards, particularly due to its narrow spread in timing.

Brazilian Irradiation Project: CAFE-MOD1 validation experimental program

International Nuclear Information System (INIS)

Mattos, Joao Roberto Loureiro de; Costa, Antonio Carlos L. da; Esteves, Fernando Avelar; Dias, Marcio Soares

1999-01-01

The Brazilian Irradiation Project whose purpose is to provide Brazil with a minimal structure to qualify the design, fabrication and quality procedures of nuclear fuels, consists of three main facilities: IEA-R1 reactor of IPEN-CNEN/SP, CAFE-MOD1 irradiation device and a unit of hot cells. The CAFE-MOD1 is based on concepts successfully used for more than 20 years in the main nuclear institutes around the world. Despite these concepts are already proved it should be adapted to each reactor condition. For this purpose, there is an ongoing experimental program aiming at the certification of the criteria and operational limits of the CAFE-MOD1 in order to get the allowance for its installation at the IEA-R1 reactor. (author)

RELAP5/MOD2: for PWR transient analysis

International Nuclear Information System (INIS)

Ransom, V.H.

1983-01-01

RELAP5 is a light water reactor system transient simulation code for use in nuclear plant safety analysis. Development of a new version, RELAP5/MOD2, has been completed and will be released to the United States Nuclear Regulatory Commission during September of 1983. The new and improved modeling capability of RELAP5/MOD2 is described and some developmental assessment results are presented. The future plans for extension to severe accident modeling are briefly discussed

RELAP5/MOD2 calculation of OECD LOFT test LP-FW-01

International Nuclear Information System (INIS)

Croxfod, M.G.; Harwood, C.; Hall, P.C.

1992-04-01

RELAP5/MOD2 is being used by GDCD for calculation of certain small break loss-of-coolant accidents and pressurized transients in the Sizewell ''B'' PWR. To test the ability of RELAP5/MOD2 to model the primary feed-and-bleed recovery procedure following a complete loss- of-feedwater event, post test calculations have been carried out of OECD LOFT test LP-FW-01. This report describes the comparison between the code calculations and the test data. It is found that although the standard version of RELAP5/MOD2 gives a reasonable prediction of the experimental transient, the long term pressure history is better calculated with a modified code version containing a revised horizontal stratification entrainment model. The latter allows an improved calculation of entrainment of liquid from the hot leg into the surge line. RELAP5/MOD2 is found to give a more accurate simulation of the experimental transient than was achieved in previous UK studies using RETRAN-02/MOD2

RELAP5/MOD1-EUR evaluation. Comparison with the INEL original version

International Nuclear Information System (INIS)

Mazzantini, O.A.

1990-01-01

In this work, the values calculated from two versions of the RELAP5/MOD1 code are compared with those measured in different tests. The first version of RELAP5 is the cycle 19 of the original version of INEL (RELAP5/MOD1-INEL) and the second version improved by EURATOM (RELAP5/MOD1-EUR) which was transferred to ENACE through agreements made with SIEMENS/KWU. (Author) [es

MOD-5A wind turbine generator program design report: Volume 1: Executive Summary

Science.gov (United States)

1984-01-01

The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator covering work performed between July 1980 and June 1984 is discussed. The report is divided into four volumes: Volume 1 summarizes the entire MOD-5A program, Volume 2 discusses the conceptual and preliminary design phases, Volume 3 describes the final design of the MOD-5A, and Volume 4 contains the drawings and specifications developed for the final design. Volume 1, the Executive Summary, summarizes all phases of the MOD-5A program. The performance and cost of energy generated by the MOD-5A are presented. Each subsystem - the rotor, drivetrain, nacelle, tower and foundation, power generation, and control and instrumentation subsystems - is described briefly. The early phases of the MOD-5A program, during which the design was analyzed and optimized, and new technologies and materials were developed, are discussed. Manufacturing, quality assurance, and safety plans are presented. The volume concludes with an index of volumes 2 and 3.

Sur la modélisation des supraconducteurs : le ``modèle de l'état critique'' de Bean, en trois dimensions

Science.gov (United States)

Bossavit, A.

1993-03-01

Macroscopic modelling of superconductors demands a substitution of some nonlinear behavior law for Ohm's law. For this, a version of Bean's “critical state” model, derived from the setting of a convex functional of the current density field, valid in dimension 3 without any previous assumption about the direction of currents, is proposed. It is shown how two standard three-dimensional finite element methods (“h-formulation” and “e-formulation”), once fitted with this model, can deal with situations were superconductors are present. La modélisation macroscopique des supraconducteurs suppose le remplacement de la loi d'Ohm par une loi de comportement non linéaire adéquate. On présente à cet effet une version du “modèle de Bean”, ou modèle de l'état critique, basée sur la construction d'une certaine fonctionnelle convexe du champ des densités de courant, qui est valable en dimension 3 sans hypothèses préalables sur la direction des courants. On montre comment adapter deux méthodes standards de calcul de courants de Foucault par élérnents finis en trois dimensions (“en h” et “en e”) à la présence de supraconducteurs, en incorporant ce modèle.

Resistance of solanum species to phytophthora infestans evaluated in the detached-leaf and whole-plant assays

International Nuclear Information System (INIS)

Akhtar, K.P.; Saleem, M.Y.; Asghar, M.

2012-01-01

The reaction of 82 tomato genotypes belonging to 8 Solanum and a Lycopersicon species against Phytophthora infestans causing late blight was determined using detached-leaf and whole-plant assays. None of the test genotypes was immune or highly resistant. Of the 82 commercial and wild genotypes only TMS-2 (male-sterile and characterized by indeterminate growth) belonging to Lycopersicon esculentum was resistant with severity index of 2.4 in the detached-leaf assay on 0-5 scale (where 5 was highly susceptible) and percent disease index (%DI) of 23.3% under the whole-plant assay. Among the remaining genotypes, 41 were susceptible and 40 were highly susceptible under the detached-leaf assay, while 18 were susceptible and 63 were highly susceptible under the whole-plant assay. However, there was a significant difference in %DI for genotypes under the whole-plant assay. The response of whole-plants to inoculation with P. infestans in the detached-leaf assay was similar in all cases. The overall screening results indicate that TMS-2 is a good source of resistance and it can be useful for the development of tomato hybrid cultivars resistant to late blight. (author)

RELAP5/MOD2 assessment at Babcock and Wilcox

International Nuclear Information System (INIS)

Nithianandan, C.K.; Shah, N.H.; Schomaker, R.J.; Turk, C.

1986-01-01

Babcock and Wilcox (B and W) has been working with the code developers at EG and G Idaho, Inc. and the NRC assessing the RELAP5/MOD2 computer code by simulating selected separate effects tests. The purpose of this B and W Owners Group-sponsored assessment was to evaluate RELAP5/MOD2 for use in design calculations for the MIST and OTIS integral system tests and in predicting pressurized water reactor (PWR) transients. B and W evaluated various versions of the code and made recommendations to improve code performance. As a result, the currently released version (Cycle 36.1) has been improved considerably over earlier versions. However, further refinements to some of the constitutive models may still be needed to further improve specific predictive capabilities of RELAP5/MOD2

Plans and status of RELAP5/MOD3

International Nuclear Information System (INIS)

Weaver, W.L.

1989-01-01

RELAP5/MOD3 is a pressurized water reactor (PWR) system analysis code being developed jointly by the US Nuclear Regulatory Commission (USNRC) and consisting of several of the countries that are members of the International Code Assessment and Applications Program (ICAP). This code development program is called the ICAP Code Improvement Program. The mission of the RELAP5/MOD3 code improvement program is to develop a code version suitable for the analysis of all transients and postulated accidents in PER systems including both large and small break loss of coolant accidents (LOCA's) as well as the full range of operational transients. The emphasis of the RELAP5/MOD3 development will be on large break LOCA since previous versions of RELAP5 were developed for and assessed against small break LOCA and operation transient test data. The paper discusses the various code models to be improved and presents the results of work completed to date

Code development and analysis program. RELAP4/MOD7 (Version 2): user's manual

International Nuclear Information System (INIS)

1978-08-01

This manual describes RELAP4/MOD7 (Version 2), which is the latest version of the RELAP4 LPWR blowdown code. Version 2 is a precursor to the final version of RELAP4/MOD7, which will address LPWR LOCA analysis in integral fashion (i.e., blowdown, refill, and reflood in continuous fashion). This manual describes the new code models and provides application information required to utilize the code. It must be used in conjunction with the RELAP4/MOD5 User's Manual (ANCR-NUREG-1335, dated September 1976), and the RELAP4/MOD6 User's Manual

Les enjeux du modèle standard

CERN Document Server

CERN. Geneva

2008-01-01

Toute la matière visible dans l'Univers est décrite par le « Modèle Standard ». Selon cette théorie, la matière est constituée d'atomes, qui contiennent des électrons orbitant autour de noyaux, dont les composants fondamentaux sont les quarks. Quatre forces fondamentales agissent entre ces particules élémentaires : les forces électromagnétique est gravitationnelle, et les interactions nucléaires forte et faible. La description fournie par le Modèle Standard de ces particules et de leurs interactions est en parfait accord avec les expériences. Néanmoins, des questions fondamentales restent sans réponse jusqu'à maintenant : d'où vient la masse des particules ? Pourquoi y a-t-il tant de types de particules ? Existe-t-il une théorie unifiée de toutes les interactions ? Quelle est la nature de la matière cachée prédite par les astrophysiciens ? Le LHC au CERN donnera des éléments de réponse à ces questions au-delà du Modèle Standard.

Mod two homology and cohomology

CERN Document Server

Hausmann, Jean-Claude

2014-01-01

Cohomology and homology modulo 2 helps the reader grasp more readily the basics of a major tool in algebraic topology. Compared to a more general approach to (co)homology this refreshing approach has many pedagogical advantages: It leads more quickly to the essentials of the subject, An absence of signs and orientation considerations simplifies the theory, Computations and advanced applications can be presented at an earlier stage, Simple geometrical interpretations of (co)chains. Mod 2 (co)homology was developed in the first quarter of the twentieth century as an alternative to integral homology, before both became particular cases of (co)homology with arbitrary coefficients. The first chapters of this book may serve as a basis for a graduate-level introductory course to (co)homology. Simplicial and singular mod 2 (co)homology are introduced, with their products and Steenrod squares, as well as equivariant cohomology. Classical applications include Brouwer's fixed point theorem, Poincaré duality, Borsuk-Ula...

Modèle exploitable pour la définition de la commande du robot

OpenAIRE

ZIMMER-CHEVRET, Sandra; LANGLOIS, Laurent; BEN ATTAR, Amarilys

2014-01-01

Ce document traite de la modélisation des actions mécaniques entre l’outil et la matière. L’objectif est de définir un modèle exploitable pour la définition de la commande du robot. Dans un premier temps, le rapport présente une synthèse bibliographique des modèles des interactions mécaniques développés à ce jour. Pour un modèle choisi, les paramètres constituant ce dernier ont été calculés à partir de données expérimentales. Puis, la validité du modèle a été étudiée. Pour une même configurat...

Cost-effectiveness analysis of microscopic observation drug susceptibility test versus Xpert MTB/Rif test for diagnosis of pulmonary tuberculosis in HIV patients in Uganda.

Science.gov (United States)

Walusimbi, Simon; Kwesiga, Brendan; Rodrigues, Rashmi; Haile, Melles; de Costa, Ayesha; Bogg, Lennart; Katamba, Achilles

2016-10-10

Microscopic Observation Drug Susceptibility (MODS) and Xpert MTB/Rif (Xpert) are highly sensitive tests for diagnosis of pulmonary tuberculosis (PTB). This study evaluated the cost effectiveness of utilizing MODS versus Xpert for diagnosis of active pulmonary TB in HIV infected patients in Uganda. A decision analysis model comparing MODS versus Xpert for TB diagnosis was used. Costs were estimated by measuring and valuing relevant resources required to perform the MODS and Xpert tests. Diagnostic accuracy data of the tests were obtained from systematic reviews involving HIV infected patients. We calculated base values for unit costs and varied several assumptions to obtain the range estimates. Cost effectiveness was expressed as costs per TB patient diagnosed for each of the two diagnostic strategies. Base case analysis was performed using the base estimates for unit cost and diagnostic accuracy of the tests. Sensitivity analysis was performed using a range of value estimates for resources, prevalence, number of tests and diagnostic accuracy. The unit cost of MODS was US$ 6.53 versus US$ 12.41 of Xpert. Consumables accounted for 59 % (US$ 3.84 of 6.53) of the unit cost for MODS and 84 % (US$10.37 of 12.41) of the unit cost for Xpert. The cost effectiveness ratio of the algorithm using MODS was US$ 34 per TB patient diagnosed compared to US$ 71 of the algorithm using Xpert. The algorithm using MODS was more cost-effective compared to the algorithm using Xpert for a wide range of different values of accuracy, cost and TB prevalence. The cost (threshold value), where the algorithm using Xpert was optimal over the algorithm using MODS was US$ 5.92. MODS versus Xpert was more cost-effective for the diagnosis of PTB among HIV patients in our setting. Efforts to scale-up MODS therefore need to be explored. However, since other non-economic factors may still favour the use of Xpert, the current cost of the Xpert cartridge still needs to be reduced further by more than

Development and application of STCP Mod 1.1

International Nuclear Information System (INIS)

Hu Zhiyi

1990-01-01

A state-of-the-art Source Term Code Package-STCP Mod 1.1 is used for assessing the release of radioactive materials to the environment in severe reactor accidents. Its structure and function, and its installation and development on CYBER computer in China are introduced. Through calculations and analyses for 4 selected severe accident sequences from ZION Nuclear Power Plant of the U.S., it shows that the developed STCP Mod 1.1 is suitable to calculate varios scenarios as long as the selections of the model and parameters are reasonable

Evaluation and assessment of reflooding models in RELAP5/Mod2.5 and RELAP5/Mod3 codes using Lehigh University and PSI-Neptun bundle experimental data

Energy Technology Data Exchange (ETDEWEB)

Sencar, M.; Aksan, N. [Paul Scherrer Institute, Villigen (Switzerland)

1995-09-01

An extensive analysis and assessment work on reflooding models of RELAP5/Mod2.5 and, RELAP5/Mod3/v5m5 and RELAP/Mod3/v7j have been performed. Experimental data from LehighUniversityv. and PSI-NEPTUN bundle reflooding experiments have been used for the assessment, since both of these tests cover a broad range of initial conditions. Within the range of these initial conditions, it was tried to identify their separate impacts on the calculated results. A total of six Lehigh University reflooding bundle tests and two PSI-NEPTUN tests with bounding initial conditions are selected for the analysis. Detailed nodalisation studies both for hydraulic and conduction heat transfer were done. On the basis of the results obtained from these cases, a base nodalisation scheme was established. All the other analysis work was performed by using this base nodalisation. RELAP5/Mod2.5 results do not change with renodalisation but RELAP5/Mod3 results are more sensitive to renodalisation. The results of RELAP5/Mod2.5 versions show very large deviations from the used experimental data. These results indicate that some of the phenomenology of the events occurring during the reflooding could not be identified. In the paper, detailed discussions on the main reasons of the deviations from the experimental data will be presented. Since, the results and findings of this study are meant to be a developmental aid, some recommendations have been drawn and some of these have already been implemented at PSI with promising results.

KONVENCIJE MOD O PRISILNEM DELU V LUČI DANAŠNJEGA ČASA

OpenAIRE

Kokoravec, Mateja

2015-01-01

Prisilno delo je antiteza dostojnega dela, za katerega se zavzema MOD. Za 21 milijonov ljudi to ni samo bled spomin iz preteklosti, ampak težka realnost še danes. Mednarodni delovni standardi, ki jih oblikuje MOD, predstavljajo temeljne minimalne socialne standarde, dogovorjene s strani glavnih udeležencev v svetovnem gospodarstvu. Z njimi si MOD prizadeva doseči dostojne delovne pogoje, saj je v današnjem svetu globalizacije za doseganje teh ciljev potrebno ukrepanje na mednarodni ravni. ...

The mod industries? The industrial logic of non-market game production

NARCIS (Netherlands)

Nieborg, D.B.; van der Graaf, S.

2008-01-01

This article seeks to make the relationship between non-market game developers (modders) and the game developer company explicit through game technology. It investigates a particular type of modding, i.e. total conversion mod teams, whose organization can be said to conform to the high-risk,

Development of sorbent therapy for multiple organ dysfunction syndrome (MODS)

International Nuclear Information System (INIS)

Li Li; Pan Jilun; Yu Yaoting

2007-01-01

As a syndrome, multiple organ dysfunction (MODS) is defined as an altered organ function in the setting of sepsis, septic shock or systemic inflammatory response syndrome (SIRS) and is the most common cause of death in intensive care units. Endotoxin, a constituent of cell walls of Gram-negative bacteria, plays an important role in the initiation and development of MODS. The cytokines, especially tumor necrosis factor alpha (TNF-alpha), are early regulators of the immune response and can induce the release of secondary cytokines. To remove endotoxin and TNF-alpha from patients with MODS, the adsorption method has proven to be most effective. In this review, we provide various methods of removal of endotoxins and TNF-alpha using different adsorbents. (topical review)

Nonaxisymmetric field effects on Alcator C-Mod

International Nuclear Information System (INIS)

Wolfe, S.M.; Hutchinson, I.H.; Granetz, R.S.; Rice, J.; Hubbard, A.; Lynn, A.; Phillips, P.; Hender, T.C.; Howell, D.F.; La Haye, R.J.; Scoville, J.T.

2005-01-01

A set of external coils (A-coils) capable of producing nonaxisymmetric, predominantly n=1, fields with different toroidal phase and a range of poloidal mode m spectra has been used to determine the threshold amplitude for mode locking over a range of plasma parameters in Alcator C-Mod [I. H. Hutchinson, R. Boivin, F. Bombarda, P. Bonoli, S. Fairfax, C. Fiore, J. Goetz, S. Golovato, R. Granetz, M. Greenwald et al., Phys. Plasmas 1, 1511 (1994)]. The threshold perturbations and parametric scalings, expressed in terms of (B 21 /B T ), are similar to those observed on larger, lower field devices. The threshold is roughly linear in density, with typical magnitudes of order 10 -4 . This result implies that locked modes should not be significantly more problematic for the International Thermonuclear Experimental Reactor [I. P. B. Editors, Nucl. Fusion 39, 2286 (1999)] than for existing devices. Coordinated nondimensional identity experiments on the Joint European Torus [Fusion Technol. 11, 13 (1987)], DIII-D [Fusion Technol. 8, 441 (1985)], and C-Mod, with matching applied mode spectra, have been carried out to determine more definitively the field and size scalings. Locked modes on C-Mod are observed to result in braking of core toroidal rotation, modification of sawtooth activity, and significant reduction in energy and particle confinement, frequently leading to disruptions. Intrinsic error fields inferred from the threshold studies are found to be consistent in amplitude and phase with a comprehensive model of the sources of field errors based on 'as-built' coil and bus-work details and coil imperfections inferred from measurements using in situ magnetic diagnostics on dedicated test pulses. Use of the A-coils to largely cancel the 2/1 component of the intrinsic nonaxisymmetric field has led to expansion of the accessible operating space in C-Mod, including operation up to 2 MA plasma current at 8 T

Automotive Stirling engine: Mod 2 design report

Science.gov (United States)

Nightingale, Noel P.

1986-01-01

The design of an automotive Stirling engine that achieves the superior fuel economy potential of the Stirling cycle is described. As the culmination of a 9-yr development program, this engine, designated the Mod 2, also nullifies arguments that Stirling engines are heavy, expensive, unreliable, demonstrating poor performance. Installed in a General Motors Chevrolet Celebrity car, this engine has a predicted combined fuel economy on unleaded gasoline of 17.5 km/l (41 mpg)- a value 50% above the current vehicle fleet average. The Mod 2 Stirling engine is a four-cylinder V-drive design with a single crankshaft. The engine is also equipped with all the controls and auxiliaries necessary for automotive operation.

SCDAP/RELAP5/MOD3 code development

International Nuclear Information System (INIS)

Allison, C.M.; Siefken, J.L.; Coryell, E.W.

1992-01-01

The SCOAP/RELAP5/MOD3 computer code is designed to describe the overall reactor coolant system (RCS) thermal-hydraulic response, core damage progression, and fission product release and transport during severe accidents. The code is being developed at the Idaho National Engineering Laboratory (INEL) under the primary sponsorship of the Office of Nuclear Regulatory Research of the US Nuclear Regulatory Commission (NRC). Code development activities are currently focused on three main areas - (a) code usability, (b) early phase melt progression model improvements, and (c) advanced reactor thermal-hydraulic model extensions. This paper describes the first two activities. A companion paper describes the advanced reactor model improvements being performed under RELAP5/MOD3 funding

Alcator C-MOD final safety analysis

International Nuclear Information System (INIS)

Fiore, C.L.

1989-06-01

This document is designed to address the safety issues involved with the Alcator C-Mod project. This report will begin with a brief description of the experimental objectives which will be followed by information concerning the site. The Alcator C-Mod experiment is a pulsed fusion experiment in which a plasma formed from small amounts of hydrogen or deuterium gas is confined in a magnetic field for short periods (∼1 s). No radioactive fuels or fissile materials are used in the device, so that no criticality hazard exists and no credible nuclear accident can occur. During deuterium operation, the production of a small number of neutrons from a short pulse could result in a small amount of short- and intermediate-lived radioactive isotopes being produced inside the experimental cell. This report will demonstrate that this does not pose an additional hazard to the general population. The health and safety hazards resulting from Alcator C-Mod occur to the workers on the experiment, each of which is described in its own chapter with the steps taken to minimize the risk to employees. These hazards include fire, chemicals and cryogenics, air quality, electrical, electromagnetic radiation, ionizing radiation, and mechanical and natural phenomena. None of these hazards is unique to the facility, and methods of protection from them are well defined and are discussed in the chapter which describes each hazard. The quality assurance program, critical to ensuring the safety aspects of the program, will also be described

Kyllinger har effektivt immunforsvar mod herpes

DEFF Research Database (Denmark)

Buchmann, Kurt

2008-01-01

Forskere ved Københavns Universitet, Fakultet for Biovidenskab har studeret kyllingens MHC molekyler og kan derigennem forklare hvorfor en særlig stamme indenfor denne art er modstandsdygtige mod en særlig herpesvirus. Udgivelsesdato: 18. januar 2008...

Estimation des paramètres de modèles pour la digestion anaérobie

OpenAIRE

Martinez , Ricardo

2003-01-01

La finalité de ce travail a été d'estimer de la meilleure manière possible des paramètres de différents modèles sur la respiration anaérobie. Dans un premier temps nous présentons les bases qu'on utilise pour construire les modèles du procédé biochimique. Puis nous faisons une analyse qualitative des modèles les plus connus sur le sujet. Dans un deuxième temps nous avons suggéré différents modèles, afin de mieux estimer les paramètres du modèle initial. Nous avons mis au point un programme d'...

The Calgary Biofilm Device: New Technology for Rapid Determination of Antibiotic Susceptibilities of Bacterial Biofilms

OpenAIRE

Ceri, H.; Olson, M. E.; Stremick, C.; Read, R. R.; Morck, D.; Buret, A.

1999-01-01

Determination of the MIC, based on the activities of antibiotics against planktonic bacteria, is the standard assay for antibiotic susceptibility testing. Adherent bacterial populations (biofilms) present with an innate lack of antibiotic susceptibility not seen in the same bacteria grown as planktonic populations. The Calgary Biofilm Device (CBD) is described as a new technology for the rapid and reproducible assay of biofilm susceptibilities to antibiotics. The CBD produces 96 equivalent bi...

The LHCD Launcher for Alcator C-Mod - Design, Construction, Calibration and Testing

International Nuclear Information System (INIS)

Hosea, J.; Beals, D.; Beck, W.; Bernabei, S.; Burke, W.; Childs, R.; Ellis, R.; Fredd, E.; Greenough, N.; Grimes, M.; Gwinn, D.; Irby, J.; Jurczynski, S.; Koert, P.; Kung, C.C.; Loesser, G.D.; Marmar, E.; Parker, R.; Rushinski, J.; Schilling, G.; Terry, D.; Vieira, R.; Wilson, J.R.; Zaks, J.

2005-01-01

MIT and PPPL have joined together to fabricate a high-power lower hybrid current drive (LHCD) system for supporting steady-state AT regime research on Alcator C-Mod. The goal of the first step of this project is to provide 1.5 MW of 4.6 GHz rf [radio frequency] power to the plasma with a compact launcher which has excellent spectral selectivity and fits into a single C-Mod port. Some of the important design, construction, calibration and testing considerations for the launcher leading up to its installation on C-Mod are presented here

Fatigue Properties of Aged Mod. 9Cr-1Mo

International Nuclear Information System (INIS)

Kim, Dae Whan; Kim, Sung Ho; Lee, Chan Bock

2007-01-01

Ferritic/Martensitic steel has a good mechanical properties and a lower thermal expansion coefficient than austenitic stainless steel. Mechanical property of Mod. 9Cr-1Mo steel is less than austenitic stainless steel at high temperature. High temperature mechanical properties are affected by precipitation for Mod. 9Cr-1Mo. FMS steel is used for long time at high temperature and the effect of aging on mechanical properties is very important. In this study, low cycle fatigue properties with aging were investigated

Assessment of RELAP5/MOD3 with condensation experiment for pure steam condensation in a vercal tube

Energy Technology Data Exchange (ETDEWEB)

Kim, Sang Jae; No, Hee Cheon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1999-12-31

The film condensation models in RELAP5/MOD3.1 and RELAP5/MOD3.2 are assessed with the data of experiment performed in the scaled down condensation experimental facility with a single vertical tube of inner diameter of 46 mm in the range of pressure 0.1 {approx} 7.5 MPa for the PSCS(Passive Secondary Condenser System). Both MOD3.1 and MOD3.2 don`t shows any reliable predictions of the experimental data. The RELAP5/MOD3.1 overpredicts the heat transfer coefficients of experiment, whereas the RELAP5/MOD3.2 underpredicts those data. It is recommended that the film condensation model in RELAP5/MOD3.2 should be modified to have a larger heat transfer coefficient than those of the present model to give the reliable predictions. 7 refs., 6 figs., 1 tab. (Author)

Assessment of RELAP5/MOD3 with condensation experiment for pure steam condensation in a vercal tube

Energy Technology Data Exchange (ETDEWEB)

Kim, Sang Jae; No, Hee Cheon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1998-12-31

The film condensation models in RELAP5/MOD3.1 and RELAP5/MOD3.2 are assessed with the data of experiment performed in the scaled down condensation experimental facility with a single vertical tube of inner diameter of 46 mm in the range of pressure 0.1 {approx} 7.5 MPa for the PSCS(Passive Secondary Condenser System). Both MOD3.1 and MOD3.2 don`t shows any reliable predictions of the experimental data. The RELAP5/MOD3.1 overpredicts the heat transfer coefficients of experiment, whereas the RELAP5/MOD3.2 underpredicts those data. It is recommended that the film condensation model in RELAP5/MOD3.2 should be modified to have a larger heat transfer coefficient than those of the present model to give the reliable predictions. 7 refs., 6 figs., 1 tab. (Author)

Vold mod børn

DEFF Research Database (Denmark)

Christensen, Else; Agerlund Sloth Larsen, Dorthe

er der gennemført en interviewundersøgelse, hvor i alt 14 sagsbehandlere fra fire forskellige store kommuner er interviewet om deres erfaringer fra sager med (mistanke om) fysisk vold mod børn, om hvordan sådanne sager sædvanligvis starter i socialforvaltningen, om undersøgelsesforløbet, om...

Assessment of RELAP/MOD2 using large break loss-of-coolant experimental data

International Nuclear Information System (INIS)

Kao, L.; Liao, L.Y.; Liang, K.S.; Wang, S.F.; Chen, Y.B.

1989-01-01

In this paper assessment of RELAP5/MOD2 using LOFT L2-5 and Semiscale S-06-3 tests are performed to provide information of the code capability and its limitation in analyzing large break LOCA of a nuclear power plant. Experiments L2-5 and S-06-3 are conducted to simulate a hypothetical LOCA which results from a 200% double-ended offset shear break in the cold-leg of a typical pressurized water reactor by utilizing scaling facilities of the LOFT and Semiscale Mod-1 systems, respectively. The RELAP5/MOD2 calculations for both tests begin with break initiation and subsequent blowdown, continue through lower plenum refill, core reflood, and terminate with corewide quench. Major phenomena of both large break loss-of-coolant tests are well predicted by RELAP5/MOD2. The results indicate that the break flow and system pressure are reasonably calculated. The cladding temperature response during blowdown period, which is the major importance to a large break LOCA, calculated by RELAP5/MOD2 shows good agreement with the test data

Comparison of MAAP4.03 with RELAP/SCDAPSIM/MOD3.2

Energy Technology Data Exchange (ETDEWEB)

Kohriyama, T.; Ohtani, M. [Technical Support Project, Institute of Nuclear Technology, Institute of Nuclear Safety System, Incorporated, Mihama, Fukui (Japan); Ezzidi, A.; Morota, H. [Computer Software Development Co., Ltd., Tokyo (Japan)

2000-11-01

The MAAP4.03 code has been widely used for analyses of severe accident phenomena. It is, however, a system level code applying simpler models and could show phenomenological uncertainties. In order to support MAAP4.03 by a more detailed mechanistic code such as RELAP/SCDAPSIM/MOD3.2, code-to-code comparisons are performed. For a typical 4 loop PWR, analyses of two severe accident sequences were executed. Both codes predicted similar tendencies until the beginning of core melt. MAAP4.03 showed earlier slumping of molten core to a lower head of a reactor pressure vessel than RELAP/SCDAPSIM/MOD3.2. MAAP4.03 considers only axial flows of molten core and crusts suddenly breach by Creep Rupture. RELAP/SCDAPSIM/MOD3.2 treats axial and radial spreads by repeated cycles of melting, flowing and freezing. Bottom crusts can be supported by intact fuel rods. By these more realistic RELAP/SCDAPSIM/MOD3.2 models, MAAP4.03 could be supported maintaining conservatism. (author)

The mod industries? The industrial logic of non-market game production

OpenAIRE

2008-01-01

Abstract This article seeks to make the relationship between non-market game developers (modders) and the game developer company explicit through game technology. It investigates a particular type of modding, i.e. total conversion mod teams, whose organization can be said to conform to the high-risk, technologically-advanced, capital-intensive, proprietary practice of the developer company. The notion ...

MOD-RTG multicouple test results and mission readiness

International Nuclear Information System (INIS)

Hartman, R.F.; Kelly, C.E.

1993-01-01

MOD-RTG represents the design configuration for the next generation of Radioisotope Thermoelectric Generators (RTG), aimed at improving specific power and efficiency over current General Purpose Heat Source Radioisotope Thermoelectric Generators (GPHS-RTGs). The modular RTG reference design has been described in previous papers (Hartman 1988). The multicouple is a key element required for the successful development of the modular RTG. The multicouple is a high voltage, thermoelectric device employing a close packed, glass bonded thermopile array of twenty thermoelectric couples, connected in a series circuit. The multicouple is designed to operate at a 1270 K hot junction temperature and a 570 K cold junction temperature, yielding a power output of approximately 2.1 watts at 3.5 volts at beginning of life. The objectives of the MOD-RTG program are focused on establishing a multicouple life test data base and life prediction capability which will permit, with reasonable margin, a projected multicouple life of greater than eight (8) years. This paper summarizes the current status of multicouple life testing and performance modeling and the level of technology readiness needed to demonstrate mission readiness for MOD-RTG

Recueil de modèles aléatoires

CERN Document Server

Chafai, Djalil

2016-01-01

Ce recueil puise sa source dans les cours de master de mathématiques appliquées et de préparation à l’épreuve de modélisation de l’agrégation de mathématiques. Le parti pris de cet ouvrage est de polariser la rédaction par les modèles plutôt que par les outils, et de consacrer chaque chapitre à un modèle. Le premier public visé est celui des enseignants-chercheurs en probabilités, débutants ou confirmés. De nombreux chapitres peuvent également bénéficier directement à des étudiants de master ou préparant l’agrégation. Collected Stochastic Models This collection was inspired by applied mathematics Master classes in stochastic modeling. The focus is on models rather than on tools, and each chapter is devoted to a specific model. Though the book is primarily intended for academics in the field of probability theory, beginners and experienced researchers alike, many chapters will also benefit students preparing to pursue their Master degree in mathematics. .

The molybdate-binding protein (ModA) of the plant pathogen Xanthomonas axonopodis pv. citri.

Science.gov (United States)

Balan, Andrea; Santacruz, Carolina P; Moutran, Alexandre; Ferreira, Rita C C; Medrano, Francisco J; Pérez, Carlos A; Ramos, Carlos H I; Ferreira, Luís C S

2006-12-01

The modABC operon of phytopathogen Xanthomonas axonopodis pv. citri (X. citri) encodes a putative ABC transporter involved in the uptake of the molybdate and tungstate anions. Sequence analyses showed high similarity values of ModA orthologs found in X. campestris pv. campestris (X. campestris) and Escherichia coli. The X. citri modA gene was cloned in pET28a and the recombinant protein, expressed in the E. coli BL21 (DE3) strain, purified by immobilized metal affinity chromatography. The purified protein remained soluble and specifically bound molybdate and tungstate with K(d) 0.29+/-0.12 microM and 0.58+/-0.14 microM, respectively. Additionally binding of molybdate drastically enhanced the thermal stability of the recombinant ModA as compared to the apoprotein. This is the first characterization of a ModA ortholog expressed by a phytopathogen and represents an important tool for functional, biochemical and structural analyses of molybdate transport in Xanthomonas species.

Moving Past "Hello World": Learning to Mod in an Online Affinity Space

Science.gov (United States)

Subramanian, Shree Durga

2012-01-01

Game modding has increasingly become a mainstream and "cutting edge" medium to foster a broad range of critical software design and programming practices to learners coming from wide-ranging educational and professional backgrounds. Participatory practices, like game modding, are highly interest-driven and entail intense engagement with…

MOD-2 wind turbine system concept and preliminary design report. Volume 2: Detailed report

Science.gov (United States)

1979-01-01

The configuration development of the MOD-2 wind turbine system (WTS) is documented. The MOD-2 WTS project is a continuation of DOE programs to develop and achieve early commercialization of wind energy. The MOD-2 is design optimized for commercial production rates which, in multiunit installations, will be integrated into a utility power grid and achieve a cost of electricity at less than four cents per kilowatt hour.

Integrated uncertainty analysis using RELAP/SCDAPSIM/MOD4.0

International Nuclear Information System (INIS)

Perez, M.; Reventos, F.; Wagner, R.; Allison, C.

2009-01-01

The RELAP/SCDAPSIM/MOD4.0 code, designed to predict the behavior of reactor systems during normal and accident conditions, is being developed as part of an international nuclear technology Software Development and Training Program (SDTP). RELAP/SCDAPSIM/MOD4.0, which is the first version of RELAP5 completely rewritten to FORTRAN 90/95/2000 standards, uses the publicly available RELAP5 and SCDAP models in combination with (a) advanced programming and numerical techniques, (b) advanced SDTP-member-developed models for LWR, HWR, and research reactor analysis, and (c) a variety of other member-developed computational packages. One such computational package is an integrated uncertainty analysis package being developed jointly by the Technical University of Catalunya (UPC) and Innovative Systems Software (ISS). The integrated uncertainty analysis approach used in the package uses the following steps: 1. Selection of the plant; 2. Selection of the scenario; 3. Selection of the safety criteria; 4. Identification and ranking of the relevant phenomena based on the safety criteria; 5. Selection of the appropriate code parameters to represent those phenomena; 6. Association of uncertainty by means of Probability Distribution Functions (PDFs) for each selected parameter; 7. Random sampling of the selected parameters according to its PDF and performing multiple computer runs to obtain uncertainty bands with a certain percentile and confidence level; 8. Processing the results of the multiple computer runs to estimate the uncertainty bands for the computed quantities associated with the selected safety criteria. The first four steps are performed by the user prior to the RELAP/SCDAPSIM/MOD4.0 analysis. The remaining steps are included with the MOD4.0 integrated uncertainty analysis (IUA) package. This paper briefly describes the integrated uncertainty analysis package including (a) the features of the package, (b) the implementation of the package into RELAP/SCDAPSIM/MOD4.0, and

Modélisation de l'évaporation en milieu poreux: développement de modèles fondamentaux et appliqués

OpenAIRE

Debaste, Frédéric

2008-01-01

L'étude des phénomènes fondamentaux detransport et de thermodynamique apparaissant lors de l'évaporationen milieu poreux permet l'investigation d'applications pratiquesvariées. Dans ce travail, nous développons des modèles fondamentauxd'évaporation en milieu poreux que nous appliquons ensuite auséchage en lit fluidisé de deux matériaux granulaires poreux :lePVC et la levure.Les modèles mis au point sont réalisés suivant une approchemultiéchelle. Nous nous intéressons tout d'abord aux phénomèn...

Origin of the diversity in DNA recognition domains in phasevarion associated modA genes of pathogenic Neisseria and Haemophilus influenzae.

Science.gov (United States)

Gawthorne, Jayde A; Beatson, Scott A; Srikhanta, Yogitha N; Fox, Kate L; Jennings, Michael P

2012-01-01

Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic bacteria. In some it has been demonstrated that the random switching of the mod (DNA methyltransferase) gene mediates the coordinated expression of multiple genes and constitutes a phasevarion (phase variable regulon). ModA of Neisseria and Haemophilus influenzae contain a highly variable, DNA recognition domain (DRD) that defines the target sequence that is modified by methylation and is used to define modA alleles. 18 distinct modA alleles have been identified in H. influenzae and the pathogenic Neisseria. To determine the origin of DRD variability, the 18 modA DRDs were used to search the available databases for similar sequences. Significant matches were identified between several modA alleles and mod gene from distinct bacterial species, indicating one source of the DRD variability was via horizontal gene transfer. Comparison of DRD sequences revealed significant mosaicism, indicating exchange between the Neisseria and H. influenzae modA alleles. Regions of high inter- and intra-allele similarity indicate that some modA alleles had undergone recombination more frequently than others, generating further diversity. Furthermore, the DRD from some modA alleles, such as modA12, have been transferred en bloc to replace the DRD from different modA alleles.

Udvikling af vaccine mod dyr tarmsygdom

DEFF Research Database (Denmark)

Jungersen, Gregers

2012-01-01

DTU Veterinærinstituttet arbejder på at udvikle en effektiv vaccine mod bakterien Lawsonia intracellularis, der forårsager den antibiotikakrævende tarmsygdom proliferativ enteritis. Bakterien driller i laboratoriet, så forskerne må finde innovative veje til vaccinen. Målet er, at vaccinens...

Obamas Fortsatte Krig mod Terror

DEFF Research Database (Denmark)

Ulrich, Philip Christian

2013-01-01

Kronikken argumenterer for at den type overvågningsskandaler som er fulgt i kølvandet på Edward Snowdens afsløringer blot er et symptom på den nye fase af krigen mod terror som Obama administrationen har ønsket at føre USA ind i. Den nye fase vil være præget af mere efterretningsvirksomhed snarere...

Beskyttelse mod passiv rygning i botilbud

DEFF Research Database (Denmark)

Faber, Louise

2018-01-01

ikke tidligere har været forbud. Denne problemstilling er aktuelt lige nu i forhold til passiv rygning, der tolereres mindre end tidligere. I denne artikel undersøges, i hvilket omfang der er mulighed for, at udstede rygeforbud på botilbud, når formålet med forbuddet er at beskytte andre beboere mod......Myndigheder har pligt til at beskytte individer mod ufrivillig sundhedsskadelig påvirkning i medfør af EMRK art. 8, stk. 1. På områder, hvor individets tolerancetærskel for sundhedsskadelig påvirkning bliver mindre end tidligere, kan der opstå behov for at udstede forbud i situationer, hvor der...... ufrivillig passiv rygning. Problemstilingen belyses i en forvaltningsretlig kontekst med udgangspunkt i dansk ret. Forfatteren konkluderer, at der er hjemmel i den danske Lov om Røgfrie Miljøer til at forbyde rygning, men at reglerne ikke giver tilstrækkelig beskyttelse i den situation, hvor en beboer...

RELAP4/MOD5: a computer program for transient thermal-hydraulic analysis of nuclear reactors and related systems. User's manual. Supplement 1, RELAP4/MOD5, Update 2

International Nuclear Information System (INIS)

Bruch, C.G.

1976-08-01

RELAP4/MOD5, Update 1 was released to the Nuclear Regulatory Commission in January 1976. Six months of extensive use of Update 1 has led to the identification and correction of a number of errors in the code, as well as some logic changes, additional Evaluation Model (EM) checks, and one model revision. These changes have culminated in the release of an improved code identified as RELAP4/MOD5, Update 2. The RELAP4/MOD5 interim User's Manual (Interim Report SRD-113-76) reflected the Update 1 version of the code. The purpose of the supplement presented is to update the Interim User's Manual for use with RELAP4/MOD5, Update 2. Major differences between Updates 1 and 2 and the checkout of Update 2 are discussed. The final version of the User's Manual will be written in accordance with Update 2 and will be published as ANCR-NUREG 1335 during September 1976. Annotation of the existing three volumes of the User's Manual to cross-reference this Supplement is recommended

Evaluation of GenoType® MTBDRplus assay for rapid detection of drug susceptibility testing of multi-drug resistance tuberculosis in Northern India

Directory of Open Access Journals (Sweden)

Anand Kumar Maurya

2013-01-01

Full Text Available Background: The problem of multi-drug resistance tuberculosis (MDR-TB is growing in several hotspots throughout the world. Rapid and accurate diagnosis of MDR-TB is crucial to facilitate early treatment and to reduce its spread in the community. The aim of the present study was to evaluate the new, novel GenoType® MTBDRplus assay for rapid detection of drug susceptibility testing (DST of MDR-TB cases in Northern India. Materials and Methods: A total of 550 specimens were collected from highly suspected drug resistant from pulmonary and extra-pulmonary TB cases. All the specimens were processed by Ziehl- Neelsen staining, culture, differentiation by the GenoType® CM assay, first line DST using BacT/ALERT 3D system and GenoType® MTBDRplus assay. The concordance of the GenoType® MTBDRplus assay was calculated in comparison with conventional DST results. Results: Overall the sensitivity for detection of rifampicin, isoniazid and MDR-TB resistance by GenoType® MTBDRplus assay was 98.0%, 98.4% and 98.2% respectively. Out of 55 MDR-TB strains, 45 (81.8%, 52 (94.5% and 17 (30.9% strains showed mutation in rpoB, katG and inhA genes respectively (P < 0.05. The most prominent mutations in rpoB, katG and inhA genes were; 37 (67.3% in S531L, 52 (94.5% in S315T1 and 11 (20% in C15T regions respectively (P < 0.05. Conclusions: Our study demonstrated a high concordance between the GenoType® MTBDRplus assay resistance patterns and those were observed by conventional DST with good sensitivity, specificity with short turnaround times and to control new cases of MDR-TB in countries with a high prevalence of MDR-TB.

Radon transport modelling: User's guide to RnMod3d

DEFF Research Database (Denmark)

Andersen, Claus Erik

2000-01-01

RnMod3d is a numerical computer model of soil-gas and radon transport in porous media. It can be used, for example, to study radon entry from soil into houses in response to indoor-outdoor pressure differences or changes in atmospheric pressure. It canalso be used for flux calculations of radon...... decay, diffusion and advection of radon can be solved. Moisture is included in the model, and partitioning ofradon between air, water and soil grains (adsorption) is taken into account. Most parameters can change in time and space, and transport parameters (diffusivity and permeability) may...... be anisotropic. This guide includes benchmark tests based on simpleproblems with known solutions. RnMod3d has also been part of an international model intercomparison exercise based on more complicated problems without known solutions. All tests show that RnMod3d gives results of good quality....

PReMod: a database of genome-wide mammalian cis-regulatory module predictions.

Science.gov (United States)

Ferretti, Vincent; Poitras, Christian; Bergeron, Dominique; Coulombe, Benoit; Robert, François; Blanchette, Mathieu

2007-01-01

We describe PReMod, a new database of genome-wide cis-regulatory module (CRM) predictions for both the human and the mouse genomes. The prediction algorithm, described previously in Blanchette et al. (2006) Genome Res., 16, 656-668, exploits the fact that many known CRMs are made of clusters of phylogenetically conserved and repeated transcription factors (TF) binding sites. Contrary to other existing databases, PReMod is not restricted to modules located proximal to genes, but in fact mostly contains distal predicted CRMs (pCRMs). Through its web interface, PReMod allows users to (i) identify pCRMs around a gene of interest; (ii) identify pCRMs that have binding sites for a given TF (or a set of TFs) or (iii) download the entire dataset for local analyses. Queries can also be refined by filtering for specific chromosomal regions, for specific regions relative to genes or for the presence of CpG islands. The output includes information about the binding sites predicted within the selected pCRMs, and a graphical display of their distribution within the pCRMs. It also provides a visual depiction of the chromosomal context of the selected pCRMs in terms of neighboring pCRMs and genes, all of which are linked to the UCSC Genome Browser and the NCBI. PReMod: http://genomequebec.mcgill.ca/PReMod.

Culture and Creativity: World of Warcraft Modding in China and the US

Science.gov (United States)

Kow, Yong Ming; Nardi, Bonnie

Modding - end-user modification of commercial hardware and software - can be traced back at least to 1961 when Spacewar! was developed by a group of MIT students on a DEC PDP-1. Spacewar! evolved into arcade games including Space Wars produced in 1977 by Cinematronics (Sotamaa 2003). In 1992, players altering Wolfenstein 3-D (1992), a first person shooter game made by id Software, overwrote the graphics and sounds by editing the game files. Learning from this experience, id Software released Doom in 1993 with isolated media files and open source code for players to develop custom maps, images, sounds, and other utilities. Players were able to pass on their modifications to others. By 1996, with the release of Quake, end-user modifications had come to be known as "mods," and modding was an accepted part of the gaming community (Kucklich 2005; Postigo 2008a, b). Since late-2005, we have been studying World of Warcraft (WoW) in which the use of mods is an important aspect of player practice (Nardi and Harris 2006; Nardi et al. 2007). Technically minded players with an interest in extending the game write mods and make them available to players for free download on distribution sites. Most modders work for free, but the distribution sites are commercial enterprises with advertising.

Penicillin-susceptible Staphylococcus aureus: susceptibility testing, resistance rates and outcome of infection.

Science.gov (United States)

Hagstrand Aldman, Malin; Skovby, Annette; I Påhlman, Lisa

2017-06-01

Staphylococcus aureus (SA) is an important human pathogen that causes both superficial and invasive infections. Penicillin is now rarely used in the treatment of SA infections due to widespread resistance and a concern about the accuracy of existing methods for penicillin susceptibility testing. The aims of the present study were to determine the frequency of penicillin-susceptible SA isolates from blood and wound cultures in Lund, Sweden, and to evaluate methods for penicillin testing in SA. We also wanted to investigate if penicillin-susceptible isolates are associated with higher mortality. Hundred blood culture isolates collected 2008/2009, 140 blood culture isolates from 2014/2015, and 141 superficial wound culture strains from 2015 were examined. Penicillin susceptibility was tested with disk diffusion according to EUCAST guidelines, and results were confirmed with a cloverleaf assay and PCR amplification of the BlaZ gene. Patient data for all bacteraemia cases were extracted from medical records. The disk diffusion method with assessment of both zone size and zone edge appearance had high accuracy in our study. About 57% of bacteraemia isolates from 2008/2009 were sensitive to penicillin compared to 29% in 2014/2015 (p penicillin susceptible. There was no difference in co-morbidity or mortality rates between patients with penicillin resistant and penicillin sensitive SA bacteraemia. Disk-diffusion is a simple and reliable method to detect penicillin resistance in SA, and susceptibility rates are significant. Penicillin has many theoretical advantages and should be considered in the treatment of SA bacteraemia when susceptible.

Modèle d’alerte des crises bancaires basé sur une approche hybride : modèle bayésien – machines à vecteurs supports

Directory of Open Access Journals (Sweden)

Taha Zaghdoudi

2016-09-01

Full Text Available Ces dernières années, la succession des crises bancaires, qui dans la plupart ont été soldées par des pertes économiques et financières énormes, a suscité l’intérêt de plusieurs chercheurs. Empiriquement, ces auteurs ont opté pour des modèles d’alerte précoce (Early Warning System pour prévenir leurs occurrences. L’objectif de ce papier est de construire un Modèle d’alerte des crises bancaires basé sur une approche hybride. Sur la base des données relatives à 22 pays qui ont subi des crises bancaires observées sur la période 1990–2011, nous avons développé un modèle d’alerte des crises bancaires. Ce modèle est basé sur une approche hybride Bayesian model averaging–Support vectors machine. Sur les 25 variables explicatives retenues, les résultats empiriques du modèle hybride ont fait ressortir 9 indicateurs qui sont considérés comme les principaux facteurs déterminants du déclenchement des crises bancaires. Ces derniers ont une probabilité postérieure d’inclusion supérieure à 0,5. Ces indicateurs potentiels sont la rentabilité nette des actifs, la compétitivité de l’intermédiation bancaire, les provisions sur les créances douteuses, les investissements directs étrangers, la concentration bancaire, la stabilité financière des banques, les produits nets financiers, le taux d’intérêt réel et le taux d’inflation.

Dimensionering af stålrammebygninger mod kipning

DEFF Research Database (Denmark)

Borchersen, E.; Frederiksen, J.O.; Skov, K.

Rapporten beskriver en metode til dimensionering af stålrammebygninger mod kipning. Metoden er baseret dels på elasticitetsteoretiske overvejelser, dels på forsøg udført med 3-charniers stålrammmer i fuld skala....

Conceptual design of the 6 MW Mod-5A wind turbine generator

Science.gov (United States)

Barton, R. S.; Lucas, W. C.

1982-01-01

The General Electric Company, Advanced Energy Programs Department, is designing under DOE/NASA sponsorship the MOD-5A wind turbine system which must generate electricity for 3.75 cent/KWH (1980) or less. During the Conceptual Design Phase, completed in March, 1981, the MOD-5A WTG system size and features were established as a result of tradeoff and optimization studies driven by minimizing the system cost of energy (COE). This led to a 400' rotor diameter size. The MOD-5A system which resulted is defined in this paper along with the operational and environmental factors that drive various portions of the design. Development of weight and cost estimating relationships (WCER's) and their use in optimizing the MOD-5A are discussed. The results of major tradeoff studies are also presented. Subsystem COE contributions for the 100th unit are shown along with the method of computation. Detailed descriptions of the major subsystems are given, in order that the results of the various trade and optimization studies can be more readily visualized.

Adhesion, biofilm formation, cell surface hydrophobicity, and antifungal planktonic susceptibility: relationship among Candida spp.

OpenAIRE

Silva-Dias, Ana; Miranda, Isabel M.; Branco, Joana; Monteiro-Soares, Matilde; Pina-Vaz, Cid?lia; Rodrigues, Ac?cio G.

2015-01-01

We have performed the characterization of the adhesion profile, biofilm formation, cell surface hydrophobicity (CSH) and antifungal susceptibility of 184 Candida clinical isolates obtained from different human reservoirs. Adhesion was quantified using a flow cytometric assay and biofilm formation was evaluated using two methodologies: XTT and crystal violet assay. CSH was quantified with the microbial adhesion to hydrocarbons test while planktonic susceptibility was assessed accordingly the C...

Biomonitoring of genotoxic risk in radar facility workers: comparison of the comet assay with micronucleus assay and chromatid breakage assay

International Nuclear Information System (INIS)

Garaj-Vrhovac, V.; Kopjar, N.

2003-01-01

Genotoxic risks of occupational exposure in a radar facility were evaluated by using alkaline comet assay, micronucleus assay and chromatid breakage assay on peripheral blood leukocytes in exposed subjects and corresponding controls. Results show that occupational exposure to microwave radiation correlates with an increase of genome damage in somatic cells. The levels of DNA damage in exposed subjects determined by using alkaline comet assay were increased compared to control and showed interindividual variations. Incidence of micronuclei was also significantly increased compared to baseline control values. After short exposure of cultured lymphocytes to bleomycin, cells of occupationally exposed subjects responded with high numbers of chromatid breaks. Although the level of chromosome damage generated by bleomycin varied greatly between individuals, in exposed subjects a significantly elevated number of chromatid breaks was observed. Our results support data reported in literature indicating that microwave radiation represents a potential DNA-damaging hazard. Alkaline comet assay is confirmed as a sensitive and highly reproducible technique for detection of primary DNA damage inflicted in somatic cells. Micronucleus assay was confirmed as reliable bio-markers of effect and chromatid breakage assay as sensitive bio-marker of individual cancer susceptibility. The results obtained also confirm the necessity to improve measures and to perform accurate health surveillance of individuals occupationally exposed to microwave radiation

International Code Assessment and Applications Program: Summary of code assessment studies concerning RELAP5/MOD2, RELAP5/MOD3, and TRAC-B

International Nuclear Information System (INIS)

Schultz, R.R.

1993-12-01

Members of the International Code Assessment Program (ICAP) have assessed the US Nuclear Regulatory Commission (USNRC) advanced thermal-hydraulic codes over the past few years in a concerted effort to identify deficiencies, to define user guidelines, and to determine the state of each code. The results of sixty-two code assessment reviews, conducted at INEL, are summarized. Code deficiencies are discussed and user recommended nodalizations investigated during the course of conducting the assessment studies and reviews are listed. All the work that is summarized was done using the RELAP5/MOD2, RELAP5/MOD3, and TRAC-B codes

Perspectives d’avenir du modèle autrichien

OpenAIRE

Neisser, Heinrich

2018-01-01

Plusieurs de ceux qui m’ont précédé ont déjà décrit des éléments de ce modèle autrichien qui suscite beaucoup d’intérêt à l’étranger, mais qui – et cela aussi a été signalé un certain nombre de fois – ne peut pas être transposé dans sa totalité à d’autres pays. De tels modèles concrets pour la solution de conflits sociaux naissent à partir d’un certain contexte historique. Ils se développent de manière pragmatique, c’est-à-dire pour résoudre, le mieux possible, des problèmes qui se posent à u...

Preliminary validation of RELAP5/Mod4.0 code for LBE cooled NACIE facility

Energy Technology Data Exchange (ETDEWEB)

Kumari, Indu; Khanna, Ashok, E-mail: akhanna@iitk.ac.in

2017-04-01

Highlights: • Detail discussion of thermo physical properties of Lead Bismuth Eutectic incorporated in the code RELAP5/Mod4.0 included. • Benchmarking of LBE properties in RELAP5/Mod4.0 against literature. • NACIE facility for three different power levels (10.8, 21.7 and 32.5 kW) under natural circulation considered for benchmarking. • Preliminary validation of the LBE properties against experimental data. • NACIE facility for power level 22.5 kW considered for validation. - Abstract: The one-dimensional thermal hydraulic computer code RELAP5 was developed for thermal hydraulic study of light water reactor as well as for nuclear research reactors. The purpose of this work is to evaluate the code RELAP5/Mod4.0 for analysis of research reactors. This paper consists of three major sections. The first section presents detailed discussions on thermo-physical properties of Lead Bismuth Eutectic (LBE) incorporated in RELAP5/Mod4.0 code. In the second section, benchmarking of RELAP5/Mod4.0 has been done with the Natural Circulation Experimental (NACIE) facility in comparison with Barone’s simulations using RELAP5/Mod3.3. Three different power levels (10.8 kW, 21.7 kW and 32.5 kW) under natural circulation conditions are considered. Results obtained for LBE temperatures, temperature difference across heat section, pin surface temperatures, mass flow rates and heat transfer coefficients in heat section heat exchanger are in agreement with Barone’s simulation results within 7% of average relative error. Third section presents validation of RELAP5/Mod4.0 against the experimental data of NACIE facility performed by Tarantino et al. test number 21 at power of 22.5 kW comparing the profiles of temperatures, mass flow rate and velocity of LBE. Simulation and experimental results agree within 7% of average relative error.

Improved guidelines for RELAP4/MOD6 reflood calculations

International Nuclear Information System (INIS)

Chen, T.H.; Fletcher, C.D.

1980-01-01

Computer simulations were performed for an extensive selection of forced- and gravity-feed reflood experiments. This effort was a portion of the assessment procedure for the RELAP4/MOD6 thermal hydraulic computer code. A common set of guidelines, based on recommendations from the code developers, was used in determining the model and user-selected input options for each calculation. The comparison of code-calculated and experimental data was then used to assess the capability of the RELAP4/MOD6 code to model the reflood phenomena. As a result of the assessment, the guidelines for determining the user-selected input options were improved

A modified MOD16 algorithm to estimate evapotranspiration over alpine meadow on the Tibetan Plateau, China

Science.gov (United States)

Chang, Y.; Ding, Y.; Zhao, Q.; Zhang, S.

2017-12-01

The accurate estimation of evapotranspiration (ET) is crucial for managing water resources in areas with extreme climates affected by climate change, such as the Tibetan Plateau (TP). The MOD16 ET product has also been validated and applied in many countries with various climates, however, its performance varies under different climates and regions. Several have studied ET based on satellite-based models on the TP. However, only a few studies on the performance of MOD16 in the TP with heterogeneous land cover have been reported. This study proposes an improved algorithm for estimating ET based on a proposed modified MOD16 method over alpine meadow on the TP in China. Wind speed and vegetation height were integrated to estimate aerodynamic resistance, while the temperature and moisture constraint for stomatal conductance were revised based on the technique proposed by Fisher et al. (2008). Moreover, Fisher's method for soil evaporation was introduced to decrease the uncertainty of soil evaporation estimation. Five representative alpine meadow sites on the TP were selected to investigate the performance of the modified algorithm. Comparisons between ET observed using Eddy Covariance (EC) and estimated using both the original method and modified method suggest that the modified algorithm had better performance than the original MOD16 method. This result was achieved considering that the coefficient of determination (R2) increased from 0.28 to 0.70, and the root mean square error (RMSE) decreased from 1.31 to 0.77 mm d-1. The modified algorithm also outperformed on precipitation days compared to non-precipitation days at Suli and Hulugou sites, while it performed well for both non-precipitation and precipitation days at Tanggula site. Comparisons of the 8-day ET estimation using the MOD16 product, original MOD16 method, and modified MOD16 method with observed ET suggest that MOD16 product underestimated ET over the alpine meadow of the TP during the growing season

An evaluation of TRAC-PF1/MOD1 computer code performance during posttest simulations of Semiscale MOD-2C feedwater line break transients

International Nuclear Information System (INIS)

Hall, D.G.; Watkins, J.C.

1987-01-01

This report documents an evaluation of the TRAC-PF1/MOD1 reactor safety analysis computer code during computer simulations of feedwater line break transients. The experimental data base for the evaluation included the results of three bottom feedwater line break tests performed in the Semiscale Mod-2C test facility. The tests modeled 14.3% (S-FS-7), 50% (S-FS-11), and 100% (S-FS-6B) breaks. The test facility and the TRAC-PF1/MOD1 model used in the calculations are described. Evaluations of the accuracy of the calculations are presented in the form of comparisons of measured and calculated histories of selected parameters associated with the primary and secondary systems. In addition to evaluating the accuracy of the code calculations, the computational performance of the code during the simulations was assessed. A conclusion was reached that the code is capable of making feedwater line break transient calculations efficiently, but there is room for significant improvements in the simulations that were performed. Recommendations are made for follow-on investigations to determine how to improve future feedwater line break calculations and for code improvements to make the code easier to use

Disruption Warning Database Development and Exploratory Machine Learning Studies on Alcator C-Mod

Science.gov (United States)

Montes, Kevin; Rea, Cristina; Granetz, Robert

2017-10-01

A database of about 1800 shots from the 2015 campaign on the Alcator C-Mod tokamak is assembled, including disruptive and non-disruptive discharges. The database consists of 40 relevant plasma parameters with data taken from 160k time slices. In order to investigate the possibility of developing a robust disruption prediction algorithm that is tokamak-independent, we focused machine learning studies on a subset of dimensionless parameters such as βp, n /nG , etc. The Random Forests machine learning algorithm provides insight on the available data set by ranking the relative importance of the input features. Its application on the C-Mod database, however, reveals that virtually no one parameter has more importance than any other, and that its classification algorithm has a low rate of successfully predicted samples, as well as poor false positive and false negative rates. Comparing the analysis of this algorithm on the C-Mod database with its application to a similar database on DIII-D, we conclude that disruption prediction may not be feasible on C-Mod. This conclusion is supported by empirical observations that most C-Mod disruptions are caused by radiative collapse due to molybdenum from the first wall, which happens on just a 1-2ms timescale. Supported by the US Dept. of Energy under DE-FC02-99ER54512 and DE-FC02-04ER54698.

TRAC-PF1/MOD1 independent assessment: Semiscale Mod-2A intermediate break test S-IB-3

International Nuclear Information System (INIS)

Kmetyk, L.N.

1986-02-01

The TRAC-PF1/MOD1 independent assessment project at Sandia National Laboratories is part of an overall effort funded by the NRC to determine the ability of various system codes to predict the detailed thermal/hydraulic response of light water reactors during accident and off-normal conditions. The TRAC code is being assessed at SNLA against test data from various integral and separate effects test facilities. As part of this assessment matrix, an intermediate break test (S-IB-3), performed at the Semiscale Mod-2A facility, has been analyzed. Using an input model with a 3-D VESSEL component, the vessel and downcomer inventories during 3-IB-3 were generally well predicted, but the core heatup was underpredicted compared to data. An equivalent calculation with an all 1-D input model ran about twice as fast as our basecase analysis using a 3-D VESSEL in the input model, but the results of the two calculations diverged significantly for many parameters of interest, with the 3-D VESSEL model results in better agreement with data. 22 refs., 100 figs

Autres modèles de prestation de services publics dans les ...

International Development Research Centre (IDRC) Digital Library (Canada)

Les écrits sur la prestation de services publics à l'aide de modèles différents ont porté jusqu'à maintenant sur des endroits très précis. Ils ont par ailleurs été circonscrits à des secteurs donnés et ont manqué d'uniformité sur le plan méthodologique. Ce projet vise à analyser les modèles de prestation de services de santé, ...

In planta assay of hygromycin susceptibility and mutant screening in rice at heading stage

International Nuclear Information System (INIS)

Fu Haowei; Li Youfa; Ma Xinghua; Shen Shengquan; Shu Xiaoli; Shu Qingyao; Chen Yang

2012-01-01

Cells and tissue of plants carrying the hygromycin phosphotransferase gene (HPT) are tolerant to antibiotic hygromycin and hence become the common selection gene for genetic transformation of crop plants, particularly monocots. The present study aimed at establishing a rapid method for in planta screening of hygromycin tolerant plants in transgenic breeding. At heading stage transgenic and conventional rice plants were sprayed with hygromycin solutions of different concentrations (25 ∼ 100 mg/L) and toxic symptoms were observed in the following days. It was observed that yellow-brown necrotic spots appeared in the leaves and grains of conventional rice varieties after foliar spraying of 50 mg/L hygromycin, and the more spots were occurred with the higher hygromycin solution. There were 21.1 and 19.2 spots per cm 2 on flag leaves of indica varieties Jiayou 99 and C10, respectively; while 27.6% and 23.5% grains were yellow-brown in the varieties, respectively. The corresponding data for two japonica varieties Jiayou 5 and R5 were 11.8 and 10.7 for leave spots and 11.2% and 11.6% for yellow-brown grains, respectively. These results indicated that the two indica varieties are more sensitive to hygromycin than the two japonica varieties. In the treatment of hygromycin with above levels, the transgenic rice line KMD1 with the HPT gene showed no toxic symptoms on leaf or panicles. The γ-rays treated M 2 population of KMD1 was sprayed with 100 mg/L hygromycin solution at heading stage and 42 plants were screened out with toxic symptoms in leaves and panicles form 120000 plants. Among the 42 hygromycin susceptible plants, 14 plants with leaves available for in vitro feeding assay were subjected to the feeding of rice striped steam borers [Chilo supperssalis (Walker)] and all showed high resistance. The above results showed that spraying of 100 mg/L hygromycin solution at heading stage would lead to visually apparent toxic symptoms in susceptibility rice plants and hence

ModFOLD6: an accurate web server for the global and local quality estimation of 3D protein models.

Science.gov (United States)

Maghrabi, Ali H A; McGuffin, Liam J

2017-07-03

Methods that reliably estimate the likely similarity between the predicted and native structures of proteins have become essential for driving the acceptance and adoption of three-dimensional protein models by life scientists. ModFOLD6 is the latest version of our leading resource for Estimates of Model Accuracy (EMA), which uses a pioneering hybrid quasi-single model approach. The ModFOLD6 server integrates scores from three pure-single model methods and three quasi-single model methods using a neural network to estimate local quality scores. Additionally, the server provides three options for producing global score estimates, depending on the requirements of the user: (i) ModFOLD6_rank, which is optimized for ranking/selection, (ii) ModFOLD6_cor, which is optimized for correlations of predicted and observed scores and (iii) ModFOLD6 global for balanced performance. The ModFOLD6 methods rank among the top few for EMA, according to independent blind testing by the CASP12 assessors. The ModFOLD6 server is also continuously automatically evaluated as part of the CAMEO project, where significant performance gains have been observed compared to our previous server and other publicly available servers. The ModFOLD6 server is freely available at: http://www.reading.ac.uk/bioinf/ModFOLD/. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Preliminary assessment of PWR Steam Generator modelling in RELAP5/MOD3

International Nuclear Information System (INIS)

Preece, R.J.; Putney, J.M.

1993-07-01

A preliminary assessment of Steam Generator (SG) modelling in the PWR thermal-hydraulic code RELAP5/MOD3 is presented. The study is based on calculations against a series of steady-state commissioning tests carried out on the Wolf Creek PWR over a range of load conditions. Data from the tests are used to assess the modelling of primary to secondary side heat transfer and, in particular, to examine the effect of reverting to the standard form of the Chen heat transfer correlation in place of the modified form applied in RELAP5/MOD2. Comparisons between the two versions of the code are also used to show how the new interphase drag model in RELAP5/MOD3 affects the calculation of SG liquid inventory and the void fraction profile in the riser

Betænkning om Indsatsen mod ungdomskriminalitet

DEFF Research Database (Denmark)

Reimann, Johan; Balvig, Flemming; Bay, Jens

Kommissionen foretager i betænkningen en samlet gennemgang af indsatsen mod ungdomskriminalitet og præsenterer på grundlag heraf en række forslag til, hvordan indsatsen kan styrkes med henblik på at gøre den så målrettet og virkningsfuld som mulig. Til brug for sine overvejelser har kommissionen...... overvejelser og forslag vedrørende indsatsen mod ungdomskriminalitet omfatter dels den forebyggende indsats, dels reaktionen på kriminalitet, der begås af børn og unge. På baggrund af erfaringerne fra eksisterende tiltag fremhæver kommissionen generelt den tidlige, helhedsorienterede, tværsektorielle og...... sammenhængende kriminalitetsforebyggende indsats som den væsentligste, hvis man for alvor ønsker at sætte effektivt ind for at begrænse ungdomskriminaliteten. Derudover stiller kommissionen en lang række forslag om konkrete tiltag med henblik på at styrke henholdsvis den forebyggende indsats og reaktionen på...

Multiple drug-susceptibility screening in Mycobacterium bovis: new nucleotide polymorphisms in the embB gene among ethambutol susceptible strains

Directory of Open Access Journals (Sweden)

Cinzia Marianelli

2015-04-01

Conclusion: All M. bovis isolates were sensitive to the most common antituberculosis drugs used for treatment. There was a good agreement between the d-REMA assay and the agar based reference method. Among ethambutol susceptible isolates, four new embB mutations were found.

Relap4/SAS/Mod5 - A version of Relap4/Mod 5 adapted to IPEN/CNEN - SP computer center

International Nuclear Information System (INIS)

Sabundjian, G.

1988-04-01

In order to improve the safety of nuclear reactor power plants several computer codes have been developed in the area of thermal - hydraulics accident analysis. Among the public-available codes, RELAP4, developed by Aerojet Nuclear Company, has been the most popular one. RELAP4 has produced satisfactory results when compared to most of the available experimental data. The purposes of the present work are: optimization of RELAP4 output and messages by writing there information in temporary records, - display of RELAP4 results in graphical form through the printer. The sample problem consists on a simplified model of a 150 MW (e) PWR whose primary circuit is simulated by 6 volumes, 8 junctions and 1 heat slab. This new version of RELAP4 (named RELAP4/SAS/MOD5) have produced results which show that the above mentioned purposes have been reached. Obviously the graphical output by RELAP4/SAS/MOD5 favors the interpretation of results by the user. (author) [pt

Qualification of the AUTOBUS Mod. 2 Code

International Nuclear Information System (INIS)

Ciarniello, U.; Peroni, P.

1988-01-01

The paper presents the qualification of AUTOBUS MOD.2 code. After a brief description of the code itself, all the critical experiments simulated by the code are illustrated to prove the accuracy of criticality calculation and power distribution. An interpretation of the results and a conclusion close this presentation

Development of a solid-phase assay for measurement of proteolytic enzyme activity

International Nuclear Information System (INIS)

Varani, J.; Johnson, K.; Kaplan, J.

1980-01-01

A solid-phase, plate assay was developed for the measurement of proteolytic enzyme activity. In this assay procedure, radiolabeled substrates were dried onto the surface of microtiter wells. Following drying, the wells were washed two times with saline to remove the nonadherent substrate. When proteolytic enzymes were added to the wells, protein hydrolysis occurred, releasing radioactivity into the supernatant fluid. The amount of protein hydrolysis that occurred was reflected by the amount of radioactivity in the supernatant fluid. When 125 I-hemoglobin was used as the substrate, it was as susceptible to hydrolysis by trypsin in the solid-phase assay as it was in solution in a standard assay procedure. Protease activity from a variety of sources (including from viable cells as well as from extracellular sources) were also able to hydrolyze the hemoglobin on the plate. 125 I-Labeled serum albumen, fibrinogen, and rat pulmonary basement membrane were also susceptible to hydrolysis by trypsin in the solid phase. When [ 14 C]elastin was dried onto the plate, it behaved in a similar manner to elastin in solution. It was resistant to hydrolysis by nonspecific proteases such as trypsin and chymotrypsin but was highly susceptible to hydrolysis by elastase. The solid-phase plate assay has several features which recommended it for routine use. It is as sensitive as standard tube assays (and much more sensitive than routinely used colormetric assays). It is quick and convenient; there are no precipitation, centrifugation, or filtration steps. In addition, very small volumes of radioactive wastes are generated. Another advantage of the solid-phase plate assay is the resistance of the dried substrates to spontaneous breakdown and to microbial contamination. Finally, this assay is suitable for use with viable cells as well as for extracellular proteases

MOD-AGE - an algorithm for age-depth model construction; U-series dated speleothems case study

Science.gov (United States)

Hercman, H.; Pawlak, J.

2012-04-01

We present MOD-AGE - a new system for chronology construction. MOD-AGE can be used for profiles that have been dated by different methods. As input data, the system uses the following basic measurements: activities, atomic ratios or age, as well as depth measurement. Based on probability distributions describing the measurement results, MOD-AGE estimates the age~depth relation and its confidence bands. To avoid the use of difficult-to-meet assumptions, MOD-AGE uses nonparametric methods. We applied a Monte Carlo simulation to model age and depth values based on the real distribution of counted data (activities, atomic ratios, depths etc.). Several fitting methods could be applied for estimating the relationships; based on several tests, we decide to use LOESS method (locally weighted scatterplot smoothing). The stratigraphic correction procedure applied in the MOD-AGE program uses a probability calculus, which assumes that the ages of all the samples are correctly estimated. Information about the probability distribution of the samples' ages is used to estimate the most probable sequence that is concordant according to the superposition rule. MOD-AGE is presented as a tool for the chronology construction of speleothems that have been analyzed by the U-series method, and it is compared to the StalAge algorithm presented by D. Scholtz and D.L Hoffmann (2011). Scholtz, D., Hoffmann, D. L., 2011. StalAge - An algorithm designed for construction of speleothem age models. Quaternary Geochronology 6, 369-382.

Mod-2 wind turbine system concept and preliminary design report. Volume 1: Executive summary

Science.gov (United States)

1979-01-01

The configuration development of the MOD-2 wind turbine system is presented. The MOD-2 is design optimized for commercial production rates which, in multi-unit installations, will be integrated into a utility power grid and achieve a cost of electricity at less than 4 cents per kilowatt hour.

The alcator C-MOD control system

International Nuclear Information System (INIS)

Bosco, J.; Fairfax, S.

1992-01-01

The Alcator C-MOD experiment includes over 30 engineering and diagnostic subsystems. The control system hardware and software is a mixture of custom and commercial products which includes sensors, signal conditioners, hard-wired controls, programmable logic controllers, displays, a hybrid analog/digital computer, networked personal computers, and networked VAX workstations. This paper describes the computer-based portions of the control system. The control system coordinates all C-MOD systems including power, vacuum, heating and cooling, access control, plasma shape and position control, and diagnostics. Programmable logic controllers (PLC's) are located near each subsystem. The control room is isolated by fiber optics. Functions that are essential to personnel or equipment safety (e.g. access control) are implemented in hardwired logic and monitored but not controlled by the PLC's. The initial configuration will include over 25 Allen-Bradley PLC-5 units. The PLCs in each subsystem are connected to personal computers (PC's) in the control room. The PC's provide graphical displays and operator interface. The Pc's are networked and share process data with each other and with a master control console and a large mimic panel

Calculation of pre and post-test of the third. proposed standard problem exercise, for the PMK-NVH-IAEA experiment using the RELAP4/MOD5 and RELAP5/MOD1

International Nuclear Information System (INIS)

Neves Conti, T. das; Sabundjian, G.; Oliveira Neto, J.M. de

1992-01-01

The results of RELAP4/MOD5 and RELAP5/MOD1 modeling tests against the steam generator tube rupture experiments performed at PMK-NVH Experimental Loop Facility (IAEA-Standard Problem Exercise-3) are presented in the report. The pre and post-test results, when compared against the experimental data were satisfactorily good, except a discrepancy in the steam-generator relief valve opening time. (author)

Three-dimensional Simulation of Gas Conductance Measurement Experiments on Alcator C-Mod

International Nuclear Information System (INIS)

Stotler, D.P.; LaBombard, B.

2004-01-01

Three-dimensional Monte Carlo neutral transport simulations of gas flow through the Alcator C-Mod subdivertor yield conductances comparable to those found in dedicated experiments. All are significantly smaller than the conductance found with the previously used axisymmetric geometry. A benchmarking exercise of the code against known conductance values for gas flow through a simple pipe provides a physical basis for interpreting the comparison of the three-dimensional and experimental C-Mod conductances

BLOW.MOD2: program for a vessel depressurization calculation with the contribution of structures

International Nuclear Information System (INIS)

Doval, A.

1990-01-01

The BLOW.MOD2 program developed to calculate pressure vessels' depressurization is presented, considering heat contribution of the structures. The results are opposite to those obtained from other more complex numerical models, being the comparison extremely satisfactory. BLOW.MOD2 is a software of the 'Systems Sub-Branch', INVAP S.E. (Author) [es

Analysis of the OECD-LOFT International Standard Problem 31 using SCDAP/RELAP5/MOD3

International Nuclear Information System (INIS)

Hohorst, J.K.; Allison, C.M.

1992-01-01

The CORA-13 bundle heating and melting experiment performed at the Kernforechungszentrum, Karlaruhe, (KfK) was analyzed at the Idaho National Engineering Laboratory (INEL) using SCDAP/RELAP5/MOD3. This analysis was part of a systematic assessment of SCDAP/RELAP5/MOD3 for the US Nuclear Regulatory Commission to (a) evaluate the variances between calculated and observed behavior, (b) identify outstanding modeling deficiencies, and (c) to evaluate the impact of ongoing modeling improvements. A brief discussion of the CORA-13 experiment including a description of the facility, important test conditions, and comparisons with other CORA experimental conditions and results is provided in this report. This report describes the results of the SCDAP/RELAPS/MOD3 analysis including a description of the SCDAP/RELAPS model of the facility, base case results, sensitivity results, and a comparison with other SCDAP/RELAP5/MOD3 code-to-data comparisons

Implementation of PWR steady state self-initialization feature into RELAP4/MOD6/U4/J3

International Nuclear Information System (INIS)

Yoshida, Kazuo

1987-07-01

A PWR steady state self-initialization feature has been implemented into the RELAP4/MOD6/U4/J3 code which is an improved version of RELAP4/MOD6 and can analyze not only large break but also small break LOCA in LWRs. This feature is originated from RELAP4/MOD7 which is the most updated released version of RELAP4 from INEL. Several FORTRAN subroutines in MOD7 related to this feature were transplanted into MOD6/U4/J3 with some improvements, which were the modification of method to take a balance of heat transfer between primary and secondary side at SG-U tubes, and to make it possible to nodalize secondary side of SG as multi-node. Advantages realized by implementation of this option are saving of time in initializaing a new model and an assurance of steady state and self consistency of input data in a small break LOCA analysis of a PWR. (author)

Rotation and transport in Alcator C-Mod ITB plasmas

Science.gov (United States)

Fiore, C. L.; Rice, J. E.; Podpaly, Y.; Bespamyatnov, I. O.; Rowan, W. L.; Hughes, J. W.; Reinke, M.

2010-06-01

Internal transport barriers (ITBs) are seen under a number of conditions in Alcator C-Mod plasmas. Most typically, radio frequency power in the ion cyclotron range of frequencies (ICRFs) is injected with the second harmonic of the resonant frequency for minority hydrogen ions positioned off-axis at r/a > 0.5 to initiate the ITBs. They can also arise spontaneously in ohmic H-mode plasmas. These ITBs typically persist tens of energy confinement times until the plasma terminates in radiative collapse or a disruption occurs. All C-Mod core barriers exhibit strongly peaked density and pressure profiles, static or peaking temperature profiles, peaking impurity density profiles and thermal transport coefficients that approach neoclassical values in the core. The strongly co-current intrinsic central plasma rotation that is observed following the H-mode transition has a profile that is peaked in the centre of the plasma and decreases towards the edge if the ICRF power deposition is in the plasma centre. When the ICRF resonance is placed off-axis, the rotation develops a well in the core region. The central rotation continues to decrease as long as the central density peaks when an ITB develops. This rotation profile is flat in the centre (0 ITB density profile is observed (0.5 ITB foot that is sufficiently large to stabilize ion temperature gradient instabilities that dominate transport in C-Mod high density plasmas.

Influence of doxorubicin on fluconazole susceptibility and efflux pump gene expression of Candida dubliniensis.

LENUS (Irish Health Repository)

Schulz, Bettina

2012-05-01

The effect of doxorubicin (DOX) on the fluconazole (FLU) susceptibility of C. dubliniensis was investigated. Isolates were exposed to DOX and FLU in a chequerboard assay and resistance gene expressions were analysed after DOX exposure. The susceptibility of the yeast to FLU was decreased in the presence of DOX in the chequerboard assay with FIC indices suggesting an antagonistic effect. Gene expression analyses showed an overexpression of CdCDR2. Hence, DOX was found to have an impact on resistance mechanisms in C. dubliniensis isolates.

Long Term Retention of Deuterium and Tritium in Alcator C-Mod

International Nuclear Information System (INIS)

FIORE, C.; LABOMBARD, B.; LIPSCHULTZ, B.; PITCHER, C.S.; SKINNER, C.H.; WAMPLER, WILLIAM R.

1999-01-01

We estimate the total in-vessel deuterium retention in Alcator C-Mod from a run campaign of about 1090 plasmas. The estimate is based on measurements of deuterium retained on 22 molybdenum tiles from the inner wall and divertor. The areal density of deuterium on the tiles was measured by nuclear reaction analysis. From these data, the in-vessel deuterium inventory is estimated to be about 0.1 gram, assuming the deuterium coverage is toroidally symmetric. Most of the retained deuterium is on the walls of the main plasma chamber, only about 2.5% of the deuterium is in the divertor. The D coverage is consistent with a layer saturated by implantation with ions and charge-exchange neutrals from the plasma. This contrasts with tokamaks with carbon plasma-facing components (PFC's) where long-term retention of tritium and deuterium is large and mainly in the divertor due to codeposition with carbon eroded by the plasma. The low deuterium retention in the C-Mod divertor is mainly due to the absence of carbon PFC's in C-Mod and the low erosion rate of Mo

64 Application d'un modèle conceptuel et d'un modèle de réseaux ...

African Journals Online (AJOL)

PR BOKO

Application of a conceptual model and a model of artificial neural networks for the ... évaluer l'impact hydrologique d'un aménagement d'un bassin ou pour ... une catégorie de modèles pluie–débit basée sur l'intelligence artificielle [4]. ..... et D.P. SOLOMATINE, « River flow forecasting using Artificial Neuronal Networks”.

MOD control center automated information systems security evolution

Science.gov (United States)

Owen, Rich

1991-01-01

The role of the technology infusion process in future Control Center Automated Information Systems (AIS) is highlighted. The following subject areas are presented in the form of the viewgraphs: goals, background, threat, MOD's AISS program, TQM, SDLC integration, payback, future challenges, and bottom line.

Vold mod førskolebørn

DEFF Research Database (Denmark)

Oldrup, Helene; Lindstrøm, Maia; Korzen, Sara

Denne rapport handler om praksis og barrierer for opsporing af og underretning om vold mod førskolebørn. Rapporten er baseret på 22 kvalitative interviews med fagfolk inden for dagpasning, sundhedsvæsen og det sociale system. Undersøgelsen viser bl.a., at en del af fagfolkene ofte tøver med at un...

RETRAN02/MOD02: an outside perspective

International Nuclear Information System (INIS)

Wei, T.Y.C.

1984-03-01

ANL recently participated in a review of the RETRAN02/MOD02 code to determine the range of accuracy, the reliability and the reproducibility of results obtained with the code for Chapter 15 non-LOCA system transients for both pressurized water reactors (PWRs) and boiling water reactors (BWRs). This paper summarizes the technical aspects of that review

Irradiation hardening of Mod.9Cr-1Mo steel

International Nuclear Information System (INIS)

Ryu, Woo-Seog; Kim, Sung-Ho; Choo, Kee-Nam; Kim, Do-Sik

2009-01-01

An irradiation test of Mod.9Cr-1Mo steel was carried out in the OR5 test hole of HANARO of a 30 MW thermal power at 390±10degC up to a fast neutron fluence of 4.4x10 19 (n/cm 2 ) (E > 1.0 MeV). The dpa of the irradiated specimens was evaluated to be 0.034 - 0.07. Tensile and impact tests of the irradiated Mod.9Cr-1Mo were done in the hot cell of the IMEF. The change of the tensile strength by irradiation was similar to the change of the yield strength. The increase of the yield and tensile strengths was up to 18% and 10% respectively. The elongation reduction of the weldment was up to 65%. (author)

Analysis of the reflood experiment by RELAP5/MOD2 code

International Nuclear Information System (INIS)

Prosek, A.; Stritar, A.

1990-01-01

The analysis of the reflood experiment on the test rig Achilles has been performed. The analysis has been done by the RELAP5/MOD2 code after the results of the experiment had been released. The experiment has been analyze in several other laboratories around the world. Our results are comparable to other analyses and are in the range of RELAP5/MOD2 capabilities. Two analyses have been done: the core only and the complete system. Computed clad temperatures in the first case are higher than measured, in the second case they are somewhat lower. (author)

Chromate Binding and Removal by the Molybdate-Binding Protein ModA.

Science.gov (United States)

Karpus, Jason; Bosscher, Michael; Ajiboye, Ifedayo; Zhang, Liang; He, Chuan

2017-04-04

Effective and cheap methods and techniques for the safe removal of hexavalent chromate from the environment are in increasingly high demand. High concentrations of hexavalent chromate have been shown to have numerous harmful effects on human biology. We show that the E. coli molybdate-binding protein ModA is a genetically encoded tool capable of removing chromate from aqueous solutions. Although previously reported to not bind chromate, we show that ModA binds chromate tightly and is capable of removing chromate to levels well below current US federal standards. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Modélisation multi-échelles en viscoplasticité endommageable de composites thermoplastiques renforcés par des fibres discontinues

OpenAIRE

ACHOUR, Nadia; CHATZIGEORGIOU, George; BONNAY, Kevin; MERAGHNI, Fodil

2017-01-01

Un nouveau modèle multi-échelles en régime viscoplastique endommageable est développé pour un composite à matrice polypropylène renforcé par des fibres de verre courtes. Basé sur l’approche en champs moyens de Mori Tanaka, il intègre une matrice viscoplastique modélisée par un modèle phénoménologique nommé par ses auteurs DSGZ et des fibres de verres modélisées par un comportement élastique linéaire. Le modèle multi-échelles permet d’intégrer la microstructure du composite préalablement carac...

Élaborer un modèle d'équilibre général dynamique et stochastique ...

International Development Research Centre (IDRC) Digital Library (Canada)

Un éventail d'outils employés en économie appliquée, comme les modèles de série chronologique ou les modèles économétriques qui s'appuient sur des propriétés ... Ces dernières années, des recherches ont montré que les modèles estimés d'EGDS peuvent produire des prévisions d'une plus grande exactitude que les ...

A Comparison of Nuclear Power Plant Simulator with RELAP5/MOD3 code about Steam Generator Tube Rupture

International Nuclear Information System (INIS)

Kim, Sung Hyun; Moon, Chan Ki; Park, Sung Baek; Na, Man Gyun

2013-01-01

The RELAP5/MOD3 code introduced in cooperation with U. S. NRC has been utilized mainly for validation calculation of accident analysis submitted by licensee in Korea. The Korea Institute of Nuclear Safety has built a verification system of LWR accident analysis with RELAP5/MOD3 code engine. Therefore, the simulator replicates the design basis accident and its results are compared with RELAP5/MOD3 code results that will have important implications in the verification of the simulator in the future. The SGTR simulations were performed by the simulator and its results were compared with ones by RELAP5/MOD3 code in this study. Thus, the results of this study can be used as materials to build the verification system of the nuclear power plant simulator. We tried to compare with RELAP5/MOD3 verification code by replicating major parameters of steam generator tube rupture using the simulator for OPR-1000 in Yonggwang training center. By comparing the changes in temperature, pressure and inventory of the reactor coolant system and main steam system during the SGTR, it was confirmed that the main behaviors of SGTR which the simulator and RELAP5/MOD3 code showed are similar. However, the behavior of SG pressure and level that are important parameters to diagnose the accident were a little different. We estimated that RELAP5/MOD3 code was not reflected the major control systems in detail, such as FWCS, SBCS and PPCS. The different behaviors of SG level and pressure in this study should be needed an additional review. As a result of the comparison, the major simulation parameters behavior by RELAP5/MOD3 code agreed well with the one by the simulator. Therefore, it is thought that RELAP5/MOD3 code is used as a tool for validation of NPP simulator in the near future through this study

Determination of Nitrate Reductase Assay Depending on the Microbial Growth

International Nuclear Information System (INIS)

El-Kabbany, H.M.

2012-01-01

A rapid micro-dilution assay for determination of the antimicrobial susceptibility of different bacterial isolates was developed. This assay is based on the ability of the most of viable organisms to reduce nitrates. The MIC or MBC could be determined by nitrate reductase (NR) only after 30 to 90 min of incubation depending on the behaviour of microbial growth. Bacterial viability is detected by a positive nitrite reduction rather than visible turbidity. The nitrate reduction assay was compared with standard micro-assay using 250 isolates of different taxa against 10 antibiotics belonging to different classes. An excellent agreement of 82.5 % was found between the two methods and only 17.5 % of 1794 trials showed difference in the determined MIC by tow-dilution interval above or below the MIC determined by the turbidimetric method under the same test conditions. However, the nitrate reduction assay was more rapid and sensitive in detecting viable bacteria and so, established an accurate estimate of the minimal inhibitory concentration (MIC) or the minimal bacterial concentration (MBC). The nitrate reduction assay offers the additional advantage that it could be used to determine the MBC without having to subculture the broth. 232 cases of resistance were detected by NR and 4 different media were tested for susceptibility test. The bacterial isolates were exposed to ultra violet (UV) light for different period

Peer review of RELAP5/MOD3 documentation

International Nuclear Information System (INIS)

Craddick, W.G.

1993-01-01

A peer review was performed on a portion of the documentation of the RELAP5/MOD3 computer code. The review was performed in two phases. The first phase was a review of Volume 3, Developmental Assessment problems, and Volume 4, Models and Correlations. The reviewers for this phase were Dr. Peter Griffith, Dr. Yassin Hassan, Dr. Gerald S. Lellouche, Dr. Marino di Marzo and Mr. Mark Wendel. The reviewers recommended a number of improvements, including using a frozen version of the code for assessment guided by a validation plan, better justification for flow regime maps and extension of models beyond their data base. The second phase was a review of Volume 6, Quality Assurance of Numerical Techniques in RELAP5/MOD3. The reviewers for the second phase were Mr. Mark Wendel and Dr. Paul T. Williams. Recommendations included correction of numerous grammatical and typographical errors and better justification for the use of Lax's Equivalence Theorem

RELAP 4/MOD 6 boiling water nodalization study

International Nuclear Information System (INIS)

Sonneck, G.; Pfau, H.

1985-09-01

The risk of nuclear steam supply systems is dominated by the core melt accidents. The first step to a realistic assessment of these sequences is the successful prediction of a loss of coolant event in a test loop. One of the codes for that is RELAP 4/MOD 6 and one of the important options in this code is the nodalization. The base of this work is the test LOCA No. 1 FIX II in Studsvik (Sweden) which also served as the OECD International Standard Problem 15. This report discusses the influence of different nodalizations, of different distributions of pressure, water and structural heat as well as of different bubble rise options, break flow coefficients, and heat transfer time steps. The most important result is that a simple RELAP 4/MOD6 model with less than 10 volumes is able to predict an experiment as LOCA No. 1 in FIX II successfully using only a fraction of the usual computing time. (Author)

Transport Studies in Alcator C-Mod ITB Plasmas

Science.gov (United States)

Fiore, C. L.; Bonoli, P. T.; Ernst, D.; Greenwald, M. J.; Ince-Cushman, A.; Lin, L.; Marmar, E. S.; Porkolab, M.; Rice, J. E.; Wukitch, S.; Rowan, W.; Bespamyatnov, I.; Phillips, P.

2008-11-01

Internal transport barriers occur in C-Mod plasmas that have off-axis ICRF heating and also in Ohmic H-mode plasmas. These ITBs are marked by highly peaked density and pressure profiles, as they rely on a reduction of particle and thermal flux in the barrier region which allows the neoclassical pinch to peak the central density without reducing the central temperature. Enhancement of several core diagnostics has resulted in increased understanding of C-Mod ITBs. Ion temperature profile measurements have been obtained using an innovative design for x-ray crystal spectrometry and clearly show a barrier forming in the ion temperature profile. The phase contrast imaging (PCI) provides limited localization of the ITB related fluctuations that increase in strength as the central density increases. Simulation of triggering conditions, integrated simulations with fluctuation measurements, parametric studies, and transport implications of fully ionized boron impurity profiles in the plasma are under study. A summary of these results will be presented.

RELAP5/MOD2 development

International Nuclear Information System (INIS)

Miller, C.S.

1986-01-01

Status of the RELAP5/MOD2 computer code is discussed. While the code is undergoing international assessment, emphasis is on user support and code maintenance with modifications allowed only for error correction and user convenience improvements. User support discussed is the response to user inquiries, maintenance of manuals and the implementation of a PC based newletter service. The major 1986 user convenience improvement is the self-initialization option. The method is discussed and examples for PWR ''U tube'' and ''once through'' plants are illustrated. Future plans are also outlined

RELAP5/MOD2 development

International Nuclear Information System (INIS)

Miller, C.S.

1987-01-01

Status of the RELAP5/MOD2 computer code is discussed. While the code is undergoing international assessment, emphasis is on user support and code maintenance with modifications allowed only for error correction and user convenience improvements. User support discussed is the response to user inquiries, maintenance of manuals and the implementation of a PC based newsletter service. The major 1986 user convenience improvement is the self-initialization option. The method is discussed and examples for PWR U tube and once through plants are illustrated. Future plans are also outlined

Modèles d'affaires ouverts : nouveaux mécanismes de revenus pour ...

International Development Research Centre (IDRC) Digital Library (Canada)

Ce projet de recherche vise à examiner les principaux modèles d'affaires qui émergent dans une société réseautée, les répercussions qu'ont ces modèles sur les droits des consommateurs et des créateurs et le rôle qu'ils peuvent jouer pour favoriser une plus grande inclusion et la diversité culturelle. Le projet se penchera ...

Detection of induced male germline mutation: Correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays

Energy Technology Data Exchange (ETDEWEB)

Singer, Timothy M. [Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont., K1A 0K9 (Canada); Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ont., K1S 5B6 (Canada); Lambert, Iain B. [Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, Ont., K1S 5B6 (Canada); Williams, Andrew [Biostatistics and Epidemiology Division, Safe Environments Programme, 6604B, Health Canada, Ottawa, Ont., K1A 0K9 (Canada); Douglas, George R. [Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont., K1A 0K9 (Canada); Yauk, Carole L. [Mutagenesis Section, Environmental and Occupational Toxicology Division, Safe Environments Programme, 0803A, Health Canada, Ottawa, Ont., K1A 0K9 (Canada)]. E-mail: carole_yauk@hc-sc.gc.ca

2006-06-25

Several rodent assays are capable of monitoring germline mutation. These include traditional assays, such as the dominant lethal (DL) assay, the morphological specific locus (SL) test and the heritable translocation (HT) assay, and two assays that have been developed more recently-the expanded simple tandem repeat (ESTR) and transgenic rodent (TGR) mutation assays. In this paper, we have compiled the limited amount of experimental data that are currently available to make conclusions regarding the comparative ability of the more recently developed assays to detect germline mutations induced by chemical and radiological agents. The data suggest that ESTR and TGR assays are generally comparable with SL in detecting germline mutagenicity induced by alkylating agents and radiation, though TGR offered less sensitivity than ESTR in some cases. The DL and HT assays detect clastogenic events and are most susceptible to mutations arising in post-spermatogonial cells, and they may not provide the best comparisons with TGR and ESTR instability. The measurement of induced ESTR instability represents a relatively sensitive method of identifying agents causing germline mutation in rodents, and may also be useful for bio-monitoring exposed individuals in the human population. Any future use of the TGR and ESTR germline mutation assays in a regulatory testing context will entail more robust and extensive characterization of assay performance. This will require substantially more data, including experiments measuring multiple endpoints, a greatly expanded database of chemical agents and a focus on characterizing stage-specific activity of mutagens in these assays, preferably by sampling epididymal sperm exposed at defined pre-meiotic, meiotic and post-meiotic stages of development.

Detection of induced male germline mutation: Correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays

International Nuclear Information System (INIS)

Singer, Timothy M.; Lambert, Iain B.; Williams, Andrew; Douglas, George R.; Yauk, Carole L.

2006-01-01

Several rodent assays are capable of monitoring germline mutation. These include traditional assays, such as the dominant lethal (DL) assay, the morphological specific locus (SL) test and the heritable translocation (HT) assay, and two assays that have been developed more recently-the expanded simple tandem repeat (ESTR) and transgenic rodent (TGR) mutation assays. In this paper, we have compiled the limited amount of experimental data that are currently available to make conclusions regarding the comparative ability of the more recently developed assays to detect germline mutations induced by chemical and radiological agents. The data suggest that ESTR and TGR assays are generally comparable with SL in detecting germline mutagenicity induced by alkylating agents and radiation, though TGR offered less sensitivity than ESTR in some cases. The DL and HT assays detect clastogenic events and are most susceptible to mutations arising in post-spermatogonial cells, and they may not provide the best comparisons with TGR and ESTR instability. The measurement of induced ESTR instability represents a relatively sensitive method of identifying agents causing germline mutation in rodents, and may also be useful for bio-monitoring exposed individuals in the human population. Any future use of the TGR and ESTR germline mutation assays in a regulatory testing context will entail more robust and extensive characterization of assay performance. This will require substantially more data, including experiments measuring multiple endpoints, a greatly expanded database of chemical agents and a focus on characterizing stage-specific activity of mutagens in these assays, preferably by sampling epididymal sperm exposed at defined pre-meiotic, meiotic and post-meiotic stages of development

Standardissimo. Les limitations théoriques du Modèle Standard. Quelles réponses y apporter?

Science.gov (United States)

Renard, F. M.

Nous présentons I 'état du Modèle Standard des interactions fortes, faibles et électromagnétiques. Après une description rapide de ses 3 secteurs, secteur de jauge (radiation), secteur fermionique (matière) et secteur scalaire (génération des masses), nous insistons sur le grand nombre de paramètres libres et sur les choix arbitraires qu'il a fallu faire dans l'élaboration du modèle. Nous faisons ressortir les problèmes techniques non résolus et nous dressons la liste des questions fondamentales restées sans réponses. Nous passons ensuite en revue les idées et méthodes proposées pour répondre à ces questions. Elles utilisent essentiellement 3 voies différentes. La première consiste à requérir plus de symétrie (extension du modèle, symétrie Gauche-Droite, Grandes Unifications, Supersymétrie,...). La seconde contient les diverses alternatives au Modèle Standard impliquant des modifications dans certains secteurs (par exemple le secteur scalaire avec le modèle de la Technicouleur) ou de façon plus violente l'hypothèse d'une sous-structure des leptons, des quarks et des bosons W et Z eux-mêmes. Une dernière voie cherche à justifier les particularités du Modèle Standard et relier ses paramètres libres en se basant sur des principes de cohérence interne du modèle. Les conséquences observables de ces diverses approches sont dans chaque cas mentionnées.

Mise en place d'une base de données pour une modélisation ...

African Journals Online (AJOL)

Mise en place d'une base de données pour une modélisation hydrologique distribuée du bassin versant du Bandama (Côte d'Ivoire) : apport d'un modèle numérique d'altitude, de la télédétection et du SIG Physitel.

Highly sensitive bacterial susceptibility test against penicillin using parylene-matrix chip.

Science.gov (United States)

Park, Jong-Min; Kim, Jo-Il; Song, Hyun-Woo; Noh, Joo-Yoon; Kang, Min-Jung; Pyun, Jae-Chul

2015-09-15

This work presented a highly sensitive bacterial antibiotic susceptibility test through β-lactamase assay using Parylene-matrix chip. β-lactamases (EC 3.5.2.6) are an important family of enzymes that confer resistance to β-lactam antibiotics by catalyzing the hydrolysis of these antibiotics. Here we present a highly sensitive assay to quantitate β-lactamase-mediated hydrolysis of penicillin into penicilloic acid. Typically, MALDI-TOF mass spectrometry has been used to quantitate low molecular weight analytes and to discriminate them from noise peaks of matrix fragments that occur at low m/z ratios (m/ztest was carried out using Parylene-matrix chip and MALDI-TOF mass spectrometry. The Parylene-matrix chip was successfully used to quantitate penicillin (m/z: [PEN+H](+)=335.1 and [PEN+Na](+)=357.8) and penicilloic acid (m/z: [PA+H](+)=353.1) in a β-lactamase assay with minimal interference of low molecular weight noise peaks. The β-lactamase assay was carried out with an antibiotic-resistant E. coli strain and an antibiotic-susceptible E. coli strain, revealing that the minimum number of E. coli cells required to screen for antibiotic resistance was 1000 cells for the MALDI-TOF mass spectrometry/Parylene-matrix chip assay. Copyright © 2015 Elsevier B.V. All rights reserved.

Phosphorylcholine impairs susceptibility to biofilm formation of hydrogel contact lenses.

Science.gov (United States)

Selan, Laura; Palma, Stefano; Scoarughi, Gian Luca; Papa, Rosanna; Veeh, Richard; Di Clemente, Daniele; Artini, Marco

2009-01-01

To compare silicone-hydrogel, poly(2-hydroxyethyl methacrylate) (pHEMA), and phosphorylcholine-coated (PC-C) contact lenses in terms of their susceptibility to biofilm formation by Staphylococcus epidermidis and Pseudomonas aeruginosa. Laboratory investigation. Biofilm formation on colonized test lenses was evaluated with confocal microscopy and in vitro antibiotic susceptibility assays. The results of the latter assays were compared with those performed on planktonic cultures of the same organism. For both microorganisms, sessile colonies on silicone-hydrogel and pHEMA lenses displayed lower antibiotic susceptibility than their planktonic counterparts. In contrast, the susceptibility of cultures growing on PC-C lenses was comparable with that for planktonic cultures. In particular, minimum inhibitory concentration for Tazocin (piperacillin plus tazobactam; Wyeth Pharmaceuticals, Aprilia, Italy; S. epidermidis) and gentamicin (P. aeruginosa) was identical, either in the presence of PC-C support or in planktonic cultures (Tazocin, aeruginosa) was two-fold higher for PC-C lenses (0.4 mug/ml) with respect to planktonic cultures (0.2 mug/ml). Confocal microscopy of lenses colonized for 24 hours with P. aeruginosa green fluorescent protein-expressing cells revealed a sessile colonization on silicone-hydrogel lens and a few isolated bacterial cells scattered widely over the surface of the PC-C lens. An increase in antibiotic susceptibility of bacterial cultures was associated with diminished bacterial adhesion. Our results indicate that PC-C lenses seem to be more resistant than silicone-hydrogel and pHEMA lenses to bacterial adhesion and colonization. This feature may facilitate their disinfection.

Genetic susceptibility of newborn daughters to oxidative stress

DEFF Research Database (Denmark)

Decordier, Ilse; De Bont, Kelly; De Bock, Kirsten

2007-01-01

A central question in risk assessment is whether newborns' susceptibility to mutagens is different from that of adults. Therefore we investigated whether genotype and/or the DNA strand break repair phenotype in combination with the MN assay would allow estimation of the relative sensitivity of a ...

TRAC-PF1/MOD1 assessment at Los Alamos

International Nuclear Information System (INIS)

Knight, T.D.

1984-01-01

The Los Alamos National Laboratory is developing the Transient Reactor Analysis Code (TRAC) to provide an advanced best-estimate predictive capability for the analysis of postulated accidents in pressurized water reactors (PWRs). Over the past several years, four distinct versions of the code have been released; each new version introduced improvements to the existing models and numerics and added new models to extend the applications of the code. The first goal of the code was to analyze large-break loss-of-coolant accidents (LOCAs), and the TRAC-P1A and TRAC-PD2 codes primarily addressed the large-break LOCA. (The TRAC-PD2/MOD1 code is essentially the same as the TRAC-PD2 code but it also includes a released set of error corrections.) The TRAC-PF1 code contained major changes to the models and trips and to the numerical methods. These modifications enhanced the computational speed of the code and improved the application to small-break LOCAs. The TRAC-PF1/MOD1 code, the latest released version, added improved steam-generator modeling, a turbine component, and a control system together with modified constitutive relations to model the balance of plant on the secondary side and to extend the applications to non-LOCA transients. The TRAC-PF1/MOD1 code also contains reasonably general reactor-kinetics modeling to facilitate the simulation of transients with delayed scram or without scram. 13 references, 24 figures

Feasibility of using auto Mod-MPI system, a novel technique for automated measurement of fetal modified myocardial performance index.

Science.gov (United States)

Lee, M-Y; Won, H-S; Jeon, E-J; Yoon, H C; Choi, J Y; Hong, S J; Kim, M-J

2014-06-01

To evaluate the reproducibility of measurement of the fetal left modified myocardial performance index (Mod-MPI) determined using a novel automated system. This was a prospective study of 116 ultrasound examinations from 110 normal singleton pregnancies at 12 + 1 to 37 + 1 weeks' gestation. Two experienced operators each measured the left Mod-MPI twice manually and twice automatically using the Auto Mod-MPI system. Intra- and interoperator reproducibility were assessed using intraclass correlation coefficients (ICCs) and the manual and automated measurements obtained by the more experienced operator were compared using Bland-Altman plots and ICCs. Both operators successfully measured the left Mod-MPI in all cases using the Auto Mod-MPI system. For both operators, intraoperator reproducibility was higher when performing automated measurements (ICC = 0.967 and 0.962 for Operators 1 and 2, respectively) than when performing manual measurements (ICC = 0.857 and 0.856 for Operators 1 and 2, respectively). Interoperator agreement was also better for automated than for manual measurements (ICC = 0.930 vs 0.723, respectively). There was good agreement between the automated and manual values measured by the more experienced operator. The Auto Mod-MPI system is a reliable technique for measuring fetal left Mod-MPI and demonstrates excellent reproducibility. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.

Improving containment mass and energy releases for CONTEMPT-LT/028 TU with RELAP5/MOD3

International Nuclear Information System (INIS)

DaSilva, H.C.; Choe, W.G.

1996-01-01

In order to obtain boundary conditions for RELAP5/MOD3 best estimate (BE) large break (LB) loss-of-coolant accident (LOCA) calculations, it is necessary to utilize a separate containment analysis code CONTEMPT-LT/028 TU, which in turn accepts mass and energy releases from the RELAP5/MOD3 calculation. When these boundary conditions are obtained, they are observed to be significantly lower than those reported in FSAR containment analyses. This motivates the present study, where RELAP5/MOD3 mass and energy releases are generated using the same assumptions listed in the FSAR containment calculations. Then CONTEMPT-LT/028 TU pressures and temperatures calculated with both sets of mass and energy releases are compared. It is seen that those obtained with the RELAP5/MOD3 input are still significantly lower, indicating a level of conservatism in the FSAR mass and energy releases that is even above that explicitly listed and also incorporated into the RELAP5/MOD3 calculation. An important conclusion from this finding is that Environmental Qualification (EQ) issues requiring containment re-analyses are likely to be easily resolved if new mass and energy releases are calculated with state-of-the-art LOCA codes modeling the entire reactor coolant system, even when conservative assumptions are incorporated

Assessment and improvement of condensation model in RELAP5/MOD3

Energy Technology Data Exchange (ETDEWEB)

Rho, Hui Cheon; Choi, Kee Yong; Park, Hyeon Sik; Kim, Sang Jae [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of); Lee, Sang Il [Korea Power Engineering Co., Inc., Seoul (Korea, Republic of)

1997-07-15

The objective of this research is to remove the uncertainty of the condensation model through the assessment and improvement of the various heat transfer correlations used in the RELAP5/MOD3 code. The condensation model of the standard RELAP5/MOD3 code is systematically arranged and analyzed. A condensation heat transfer database is constructed from the previous experimental data on various condensation phenomena. Based on the constructed database, the condensation models in the code are assessed and improved. An experiment on the reflux condensation in a tube of steam generator in the presence of noncondensable gases is planned to acquire the experimental data.

A new formulation of the law of octic reciprocity for primes ≡±3(mod8 and its consequences

Directory of Open Access Journals (Sweden)

Richard H. Hudson

1982-01-01

Full Text Available Let p and q be odd primes with q≡±3(mod8, p≡1(mod8=a2+b2=c2+d2 and with the signs of a and c chosen so that a≡c≡1(mod4. In this paper we show step-by-step how to easily obtain for large q necessary and sufficient criteria to have (−1(q−1/2q(p−1/8≡(a−bd/acj(modp for j=1,…,8 (the cases with j odd have been treated only recently [3] in connection with the sign ambiguity in Jacobsthal sums of order 4. This is accomplished by breaking the formula of A.E. Western into three distinct parts involving two polynomials and a Legendre symbol; the latter condition restricts the validity of the method presented in section 2 to primes q≡3(mod8 and significant modification is needed to obtain similar results for q≡±1(mod8. Only recently the author has completely resolved the case q≡5(mod8, j=1,…,8 and a sketch of the method appears in the closing section of this paper.

Correlation ECE diagnostic in Alcator C-Mod

International Nuclear Information System (INIS)

Sung, C.; Irby, J.; Leccacorvi, R.; Vieira, R.; Oi, C.; Rice, J.; Reinke, M.; Gao, C.; Ennever, P.; Porkolab, M.; Churchill, R.; Theiler, C.; Walk, J.; Hughes, J.; Hubbard, A.; Greenwald, M.

2015-01-01

Correlation ECE (CECE) is a diagnostic technique that allows measurement of small amplitude electron temperature, Te, fluctuations through standard cross-correlation analysis methods. In Alcator C-Mod, a new CECE diagnostic has been installed[Sung RSI 2012], and interesting phenomena have been observed in various plasma conditions. We find that local Te fluctuations near the edge (ρ ~ 0:8) decrease across the linearto- saturated ohmic confinement transition, with fluctuations decreasing with increasing plasma density [Sung NF 2013], which occurs simultaneously with rotation reversals [Rice NF 2011]. Te fluctuations are also reduced across core rotation reversals with an increase of plasma density in RF heated L-mode plasmas, which implies that the same physics related to the reduction of Te fluctuations may be applied to both ohmic and RF heated L-mode plasmas. In I-mode plasmas, we observe the reduction of core Te fluctuations, which indicates changes of turbulence occur not only in the pedestal region but also in the core across the L/I transition [White NF 2014]. The present CECE diagnostic system in C-Mod and these experimental results are described in this paper

Real-time sensing and gas jet mitigation of VDEs on Alcator C-Mod

Science.gov (United States)

Granetz, R. S.; Wolfe, S. M.; Izzo, V. A.; Reinke, M. L.; Terry, J. L.; Hughes, J. W.; Zhurovich, K.; Whyte, D. G.; Bakhtiari, M.; Wurden, G.

2006-10-01

Experiments have been carried out in Alcator C-Mod to test the effectiveness of gas jet disruption mitigation of VDEs with real-time detection and triggering by the C-Mod digital plasma control system (DPCS). The DPCS continuously computes the error in the plasma vertical position from the magnetics diagnostics. When this error exceeds an adjustable preset value, the DPCS triggers the gas jet valve (with a negligible latency time). The high-pressure gas (argon) only takes a few milliseconds to enter the vacuum chamber and begin affecting the plasma, but this is comparable to the VDE timescale on C-Mod. Nevertheless, gas jet injection reduced the halo current, increased the radiated power fraction, and reduced the heating of the divertor compared to unmitigated disruptions, but not quite as well as in earlier mitigation experiments with vertically stable plasmas. Presumably a faster overall response time would be beneficial, and several ways to achieve this will also be discussed.

Experiment data report for Semiscale Mod-1 Test S-05-1 (alternate ECC injection test)

International Nuclear Information System (INIS)

Feldman, E.M.; Patton, M.L. Jr.; Sackett, K.E.

1977-02-01

Recorded test data are presented for Test S-05-1 of the Semiscale Mod-1 alternate ECC injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-1 was conducted from initial conditions of 2263 psia and 544 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the vessel lower plenum to simulate emergency core coolant injection in a PWR, with the flow rate based on system volume scaling

Power oscillation of the Mod-0 wind turbine

Science.gov (United States)

Seidel, R. C.

1978-01-01

The Mod-0 power has noise components with varying frequency patterns. Magnitudes reach more than forty percent power at the frequency of twice per rotor revolution. Analysis of a simple torsional model of the power train predicts less than half the observed magnitude and does not explain the shifting frequencies of the noise patterns.

Modélisation du comportement et des couplages HMC des milieux poreux

OpenAIRE

Hoang , Ha

2012-01-01

Modelling of the behavior and the couplings HMC of the porous circles; La modélisation du comportement hydromécanique chimique des milieux poreux saturés et non saturés est abordée au niveau microscopique et mésoscopique. Au niveau microscopique la modélisation des écoulements diphasiques est basée sur une représentation du réseau poral comme un ensemble de tubes dont les orientations et les rayons sont choisis sur un principe d’équivalence avec les pores. L’algorithme régissant la génération...

Peer review of RELAP5/MOD3 documentation

International Nuclear Information System (INIS)

Craddick, W.G.

1994-01-01

A peer review was performed on a portion of the documentation of the RELAP5/MOD3 computer code. The review was performed in two phases. The first phase was a review of Vol. III, Developmental Assessment Problems, and Vol. IV, Models and Correlations. The reviewers for this phase were Dr. Peter Griffith, Dr. Yassin Hassan, Dr. Gerald S. Lellouche, Dr. Marino di Marzo and Mr. Mark Wendel. The reviewers recommended a number of improvements, including using a frozen version of the code for assessment guided by a validation plan, better discussion of discrepancies between the code and experimental data, and better justification for flow regime maps and extension of models beyond their data base. The second phase was a review of Vol. VI, Quality Assurance of Numerical Techniques in RELAP5/MOD3. The reviewers for the second phase were Mr. Mark Wendel and Dr. Paul T. Williams. Recommendations included correction of numerous grammatical and typographical errors and better justification for the use of Lax's Equivalence Theorem

Investigation of RF-enhanced plasma potentials on Alcator C-Mod

International Nuclear Information System (INIS)

Ochoukov, R.; Whyte, D.G.; Brunner, D.; Cziegler, I.; LaBombard, B.; Lipschultz, B.; Myra, J.; Terry, J.; Wukitch, S.

2013-01-01

Radio frequency (RF) sheath rectification is a leading mechanism suspected of causing anomalously high erosion of plasma facing materials in RF-heated plasmas on Alcator C-Mod. An extensive experimental survey of the plasma potential (Φ P ) in RF-heated discharges on C-Mod reveals that significant Φ P enhancement (>100 V) is found on outboard limiter surfaces, both mapped and not mapped to active RF antennas. Surfaces that magnetically map to active RF antennas show Φ P enhancement that is, in part, consistent with the recently proposed slow wave rectification mechanism. Surfaces that do not map to active RF antennas also experience significant Φ P enhancement, which strongly correlates with the local fast wave intensity. In this case, fast wave rectification is a leading candidate mechanism responsible for the observed enhancement

Primes of the form x2 + dy2 with x ≡ 0(mod N)

Indian Academy of Sciences (India)

A Mersenne prime Mp = 2p −1 is a quadratic residue of 7 if and only if p ≡ 1(mod 3). In such cases Mp ≡ 1(mod 7) ... if the norm of Mp,α is a rational prime, then Mp,α is a quadratic residue of 7. Then it is proved that, for ..... [13] Vaugham T P, The construction of unramified cyclic quartic extension of Q(. √ m),. Math. Comput.

Assessment of PWR Steam Generator modelling in RELAP5/MOD2

International Nuclear Information System (INIS)

Putney, J.M.; Preece, R.J.

1993-06-01

An assessment of Steam Generator (SG) modelling in the PWR thermal-hydraulic code RELAP5/MOD2 is presented. The assessment is based on a review of code assessment calculations performed in the UK and elsewhere, detailed calculations against a series of commissioning tests carried out on the Wolf Creek PWR and analytical investigations of the phenomena involved in normal and abnormal SG operation. A number of modelling deficiencies are identified and their implications for PWR safety analysis are discussed -- including methods for compensating for the deficiencies through changes to the input deck. Consideration is also given as to whether the deficiencies will still be present in the successor code RELAP5/MOD3

Study of MOD control system in ECRH

International Nuclear Information System (INIS)

Su Yu; Liu Baohua; Ding Tonghai; Kuang Guangli

2005-01-01

High-voltage power supply (HVPS) is one of the important components in ECRH (Electron Cyclotron Resonance Heating). The MOD (modulator) control system is a key of the operation of HVPS and the whole system. The background and principium is introduced in this paper, especially the detail of the hardware and software of the control system is shown. The experiment, that shows stability, accuracy and reliability had reached the expected goal. (authors)

Experiments and Simulations of ITER-like Plasmas in Alcator C-Mod

International Nuclear Information System (INIS)

Wilson, R.; Kessel, C.E.; Wolfe, S.; Hutchinson, I.H.; Bonoli, P.; Fiore, C.; Hubbard, A.E.; Hughes, J.; Lin, Y.; Ma, Y.; Mikkelsen, D.; Reinke, M.; Scott, S.; Sips, A.C.C.; Wukitch, S.

2010-01-01

Alcator C-Mod is performing ITER-like experiments to benchmark and verify projections to 15 MA ELMy H-mode Inductive ITER discharges. The main focus has been on the transient ramp phases. The plasma current in C-Mod is 1.3 MA and toroidal field is 5.4 T. Both Ohmic and ion cyclotron (ICRF) heated discharges are examined. Plasma current rampup experiments have demonstrated that (ICRF and LH) heating in the rise phase can save voltseconds (V-s), as was predicted for ITER by simulations, but showed that the ICRF had no effect on the current profile versus Ohmic discharges. Rampdown experiments show an overcurrent in the Ohmic coil (OH) at the H to L transition, which can be mitigated by remaining in H-mode into the rampdown. Experiments have shown that when the EDA H-mode is preserved well into the rampdown phase, the density and temperature pedestal heights decrease during the plasma current rampdown. Simulations of the full C-Mod discharges have been done with the Tokamak Simulation Code (TSC) and the Coppi-Tang energy transport model is used with modified settings to provide the best fit to the experimental electron temperature profile. Other transport models have been examined also.

A study of the dispersed flow interfacial heat transfer model of RELAP5/MOD2.5 and RELAP5/MOD3

Energy Technology Data Exchange (ETDEWEB)

Andreani, M. [Swiss Federal Institute of Technology, Zurich (Switzerland); Analytis, G.T.; Aksan, S.N. [Paul Scherrer Institute, Villigen (Switzerland)

1995-09-01

The model of interfacial heat transfer for the dispersed flow regime used in the RELAP5 computer codes is investigated in the present paper. Short-transient calculations of two low flooding rate tube reflooding experiments have been performed, where the hydraulic conditions and the heat input to the vapour in the post-dryout region were controlled for the predetermined position of the quench front. Both RELAP5/MOD2.5 and RELAP5/MOD3 substantially underpredicted the exit vapour temperature. The mass flow rate and quality, however, were correct and the heat input to the vapour was larger than the actual one. As the vapour superheat at the tube exit depends on the balance between the heat input from the wall and the heat exchange with the droplets, the discrepancy between the calculated and the measured exit vapour temperature suggested that the inability of both codes to predict the vapour superheat in the dispersed flow region is due to the overprediction of the interfacial heat transfer rate.

Participer à l’évolution du modèle québécois

Directory of Open Access Journals (Sweden)

Manuel Dussault

2002-10-01

Full Text Available Ce court texte vise à expliquer la position de l’Association des manufacturiers et exportateurs du Québec (AMEQ sur la question du modèle québécois. Pour l’association, il existe un modèle québécois, comme il existe un modèle français, américain, japonais ou autres. Ce modèle, ni tout a fait original, ni tout à fait pareil aux autres, est à la fois libéral et social démocratique. Il se caractérise par le nationalisme, l’équité et la concertation. L’histoire économique moderne est devenue, en partie celle du rôle de l’État par les leviers économiques qu’il a mis en place depuis la révolution tranquille. Le modèle québécois a permis le rattrapage sur l’Ontario mais, en même temps, n’a pas réussi à abaisser son taux de chômage au niveau de la moyenne canadienne. Et après mûres réflexion, l’AMEQ est d’avis que la solution ne se trouve pas dans l’adoption d’éléments issus du modèle américain. Mais, le renouveau du modèle passe par la contribution de la société civile et non seulement par des solutions étatiques, marchandes ou encore de la concertation institutionnaliséeThis short text aims at explaining the position of the Association of the manufacturers and exporters of Quebec (AMEQ on the question of the Quebecois model. For the association, there is a Quebecois model, as there is a French, American, Japanese model or other. This model, neither everything made original, nor the completely similar to the others, is liberal and social at the same moment democratic. It is characterized by the nationalism, the equity and the dialogue. The modern economic story, partially that of the role of the state by the economic control levers which it set up since the “Révolution tranquille”. The Quebecois model allowed the picking up on Ontario but, at the same time, did not manage to lower its unemployment rate at the level of the Canadian avarage. And after reflection, the AMEQ is of

The susceptibility of circulating human influenza viruses to tizoxanide, the active metabolite of nitazoxanide.

Science.gov (United States)

Tilmanis, Danielle; van Baalen, Carel; Oh, Ding Yuan; Rossignol, Jean-Francois; Hurt, Aeron C

2017-11-01

Nitazoxanide is a thiazolide compound that was originally developed as an anti-parasitic agent, but has recently been repurposed for the treatment of influenza virus infections. Thought to exert its anti-influenza activity via the inhibition of hemagglutinin maturation and intracellular trafficking in infected cells, the effectiveness of nitazoxanide in treating patients with non-complicated influenza is currently being assessed in phase III clinical trials. Here, we describe the susceptibility of 210 seasonal influenza viruses to tizoxanide, the active circulating metabolite of nitazoxanide. An optimised cell culture-based focus reduction assay was used to determine the susceptibility of A(H1N1)pdm09, A(H3N2), and influenza B viruses circulating in the southern hemisphere from the period March 2014 to August 2016. Tizoxanide showed potent in vitro antiviral activity against all influenza viruses tested, including neuraminidase inhibitor-resistant viruses, allowing the establishment of a baseline level of susceptibility for each subtype. Median EC 50 values (±IQR) of 0.48 μM (0.33-0.71), 0.62 μM (0.56-0.75), 0.66 μM (0.62-0.69), and 0.60 μM (0.51-0.67) were obtained for A(H1N1)pdm09, A(H3N2), B(Victoria lineage), and B(Yamagata lineage) influenza viruses respectively. There was no significant difference in the median baseline tizoxanide susceptibility for each influenza subtype tested. This is the first report on the susceptibility of circulating viruses to tizoxanide. The focus reduction assay format described is sensitive, robust, and less laborious than traditional cell based antiviral assays, making it highly suitable for the surveillance of tizoxanide susceptibility in circulating seasonal influenza viruses. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Analysis of Rod Withdrawal at Power (RWAP) Accident using ATHLET Mod 2.2 Cycle A and RELAP5/mod 3.3 Codes

International Nuclear Information System (INIS)

Bencik, V.; Cavlina, N.; Grgic, D.

2012-01-01

The system code ATHLET is being developed at Gesellschaft fuer Anlagen-und Reaktorsicherheit (GRS) in Germany. In 1996, the NPP Krsko (NEK) input deck for ATHLET Mod 1.1 Cycle C has been developed at Faculty of Electrical Engineering (FER), University of Zagreb. The input deck was tested by analyzing the realistic plant event 'Main Steam Isolation Valve Closure' and the results were assessed against the measured data. The input deck was established before plant modernization that took place in 2000 and included the power uprate and SG replacement. The released ATHLET version (Mod 2.2 Cycle A) is now being available at FER Zagreb. Accordingly, the NEK input deck for ATHLET Mod 2.2 Cycle A has been developed. A completely new input deck has been created taking into account the large number of changes due to power uprate and SG replacement as well as taking advantage of developmental work on NEK data base performed at FER. The new NEK input deck for ATHLET code has been tested by analyzing the Rod Withdrawal Power (RWAP) accident and the results were assessed against the analysis performed by RELAP5/mod 3.3 code. The RWAP accident can be either Departure from Nucleate Boiling (DNB) ratio or overpower limiting accident depending on initial power and reactivity insertion rate. Since the automatic rod control system is assumed unavailable, the only negative reactivity is due to Doppler and moderator feedback. Consequently, the nuclear power and the transferred heat in the steam generators (SGs) increase. Since the steam flow to the turbine and the extracted power from the SGs remain constant, the SG secondary pressure and the temperatures on the primary side increase. Unless terminated by manual or automatic action, the power mismatch between primary and secondary side and the resultant coolant temperature rise could eventually result in DNB ratio and/or fuel centreline melt. In order to avoid core damage, the reactor protection system is designed to automatically

Migration of alcator C-Mod computer infrastructure to Linux

International Nuclear Information System (INIS)

Fredian, T.W.; Greenwald, M.; Stillerman, J.A.

2004-01-01

The Alcator C-Mod fusion experiment at MIT in Cambridge, Massachusetts has been operating for twelve years. The data handling for the experiment during most of this period was based on MDSplus running on a cluster of VAX and Alpha computers using the OpenVMS operating system. While the OpenVMS operating system provided a stable reliable platform, the support of the operating system and the software layered on the system has deteriorated in recent years. With the advent of extremely powerful low cost personal computers and the increasing popularity and robustness of the Linux operating system a decision was made to migrate the data handling systems for C-Mod to a collection of PC's running Linux. This paper will describe the new system configuration, the effort involved in the migration from OpenVMS, the results of the first run campaign under the new configuration and the impact the switch may have on the rest of the MDSplus community

Experiment data report for semiscale Mod-1 test S-06-4 (LOFT counterpart test)

International Nuclear Information System (INIS)

Gillins, R.L.; Sackett, K.E.; Coppin, C.E.

1977-12-01

Recorded test data are presented for Test S-06-4 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-4 was conducted from initial conditions of 15,653 kPa and 564 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 100 percent of the maximum peak power density

Experiment data report for semiscale Mod-1 test S-06-1 (LOFT counterpart test)

International Nuclear Information System (INIS)

Collins, B.L.; Patton, M.L. Jr.; Sackett, K.E.

1977-07-01

Recorded test data are presented for Test S-06-1 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying an hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-1 was conducted from initial conditions of 15 568 kPa and 564 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 30% of the maximum peak power density

Experiment data report for semiscale Mod-1 Test S-06-2 (LOFT counterpart test)

International Nuclear Information System (INIS)

Patton, M.L. Jr.; Collins, B.L.; Sackett, K.E.

1977-08-01

Recorded test data are presented for Test S-06-2 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying an hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-2 was conducted from initial conditions of 15 513 kPa and 563 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 50% of the maximum peak power density

Mod-5A wind turbine generator program design report. Volume 3: Final design and system description, book 2

Science.gov (United States)

1984-01-01

The design, development and analysis of the 7.3MW MOD-5A wind turbine generator is documented. The report is divided into four volumes: Volume 1 summarizes the entire MOD-5A program, Volume 2 discusses the conceptual and preliminary design phases, Volume 3 describes the final design of the MOD-5A, and Volume 4 contains the drawings and specifications developed for the final design. Volume 3, book 2 describes the performance and characteristics of the MOD-5A wind turbine generator in its final configuration. The subsystem for power generation, control, and instrumentation subsystems is described in detail. The manufacturing and construction plans, and the preparation of a potential site on Oahu, Hawaii, are documented. The quality assurance and safety plan, and analyses of failure modes and effects, and reliability, availability and maintainability are presented.

Internal transport barriers on Alcator C-Mod

International Nuclear Information System (INIS)

Fiore, C.L.; Rice, J.E.; Bonoli, P.T.; Boivin, R.L.; Goetz, J.A.; Hubbard, A.E.; Hutchinson, I.H.; Granetz, R.S.; Greenwald, M.J.; Marmar, E.S.; Mossessian, D.; Porkolab, M.; Taylor, G.; Snipes, J.; Wolfe, S.M.; Wukitch, S.J.

2001-01-01

The formation of internal transport barriers (ITBs) has been observed in the core region of Alcator C-Mod [I. H. Hutchinson et al., Phys. Plasmas 1, 1511 (1994)] under a variety of conditions. The improvement in core confinement following pellet injection (pellet enhanced performance or PEP mode) has been well documented on Alcator C-Mod in the past. Recently three new ITB phenomena have been observed which require no externally applied particle or momentum input. Short lived ITBs form spontaneously following the high confinement to low confinement mode transition and are characterized by a large increase in the global neutron production (enhanced neutron or EN modes). Experiments with ion cyclotron range of frequencies power injection to the plasma off-axis on the high field side results in the central density rising abruptly and becoming peaked. The ITB formed at this time lasts for ten energy confinement times. The central toroidal rotation velocity decreases and changes sign as the density rises. Similar spontaneous ITBs have been observed in ohmically heated H-mode plasmas. All of these ITB events have strongly peaked density profiles with a minimum in the density scale length occurring near r/a=0.5 and have improved confinement parameters in the core region of the plasma

Les industries culturelles en mutation : des modèles en question

Directory of Open Access Journals (Sweden)

Lucien Perticoz

2012-09-01

Full Text Available La présente contribution se propose de questionner la notion de modèles socio-économiques dans le cadre des travaux relatifs aux mutations des industries culturelles. À cette fin, l’exposé se déroulera en trois temps : nous reviendrons tout d’abord sur les caractéristiques essentielles des modèles génériques (modèle éditorial et de flot ainsi que sur leurs principaux apports ; nous expliquerons ensuite dans quelle mesure ils doivent être considérés, non comme une description fidèle de la réalité dont ils entendent rendre compte, mais davantage comme des règles du jeu permettant d’appréhender les mutations à l’œuvre ; enfin, à l’aune de la numérisation des contenus et de leur consommation via Internet, nous interrogerons l’hypothèse de l’émergence de nouveaux modèles génériques. En conclusion, nous insisterons sur la nécessité, à notre sens, de prendre en compte l’évolution des pratiques culturelles médiatiques en tant que dimension structurante de ces modèles.This paper aims to question the concept of socio-economic models within the framework of research about cultural industries mutations. For this purpose, our presentation will proceed in three parts : first of all, we will reconsider the essential characteristics of the generic models (publishing model and flow model and their main contributions to the research ; we will explain then why they must be considered, not as a faithful description of the reality of which they intend to give an account, but more like rules of the game allowing to understand the mutations of cultural industries ; finally, considering the digitalization of contents and their consumption using Internet, we will question the hypothesis of the emergence of new generic models. In conclusion, we will insist on the importance, from our opinion, to take into account the evolution of the media cultural practices as a structuring dimension of these models.

Second Generation HTs Wire Based on RABiTS Substrates and MOD YBCO

Energy Technology Data Exchange (ETDEWEB)

Schoop, U. [American Superconductor Corporation, Westborough, MA; Rupich, Marty [American Superconductor Corporation, Westborough, MA; Thieme, C. L. H. [American Superconductor Corporation, Westborough, MA; Verebelyi, D. T. [American Superconductor Corporation, Westborough, MA; Zhang, W. [American Superconductor Corporation, Westborough, MA; Li, Xiaoping [American Superconductor Corporation, Westborough, MA; Kodenkandath, Thomas [American Superconductor Corporation, Westborough, MA; Nguyen, N. [American Superconductor Corporation, Westborough, MA; Siegal, E. E. [American Superconductor Corporation, Westborough, MA; Civale, L. [Los Alamos National Laboratory (LANL); Holesinger, T. G. [Los Alamos National Laboratory (LANL); Maiorov, B. [Los Alamos National Laboratory (LANL); Goyal, Amit [ORNL; Paranthaman, Mariappan Parans [ORNL

2005-01-01

The performance of Second Generation (2G) high temperature superconducting wire manufactured by continuous reel-to-reel processes is nearing the 300 A/cm-width (77 K, self field) performance threshold for commercial power cable applications. The 2G manufacturing approach under development at American Superconductor is based on the combination of the RABiTS substrate-buffer technology with metal organic deposition (MOD) of the YBCO layer. The capability of this process has been demonstrated in multiple 10 meter lengths with critical currents exceeding 250 A/cm-width with high uniformity and reproducibility. Critical currents of 380 A/cm-width have been achieved in short length samples prepared by the same basic process. The incorporation of nanoparticles ('nanodots') into the YBCO layer using the MOD process has resulted in a 2-fold improvement in the critical current at 65 K in a 3 T field. The research and development focus at ASMC is now directed toward the economical scale-up of the RABiTS/MOD process, optimization of the conductor properties for targeted applications and the use of 2G wire in initial demonstration applications.

Radon transport modelling: User's guide to RnMod3d

International Nuclear Information System (INIS)

Andersen, C.E.

2000-08-01

RnMod3d is a numerical computer model of soil-gas and radon transport in porous media. It can be used, for example, to study radon entry from soil into houses in response to indoor-outdoor pressure differences or changes in atmospheric pressure. It can also be used for flux calculations of radon from the soil surface or to model radon exhalation from building materials such as concrete. The finite-volume model is a technical research tool, and it cannot be used meaningfully without good understanding of the involved physical equations. Some understanding of numerical mathematics and the programming language Pascal is also required. Originally, the code was developed for internal use at Risoe only. With this guide, however, it should be possible for others to use the model. Three-dimensional steady-state or transient problems with Darcy flow of soil gas and combined generation, radioactive decay, diffusion and advection of radon can be solved. Moisture is included in the model, and partitioning of radon between air, water and soil grains (adsorption) is taken into account. Most parameters can change in time and space, and transport parameters (diffusivity and permeability) may be anisotropic. This guide includes benchmark tests based on simple problems with known solutions. RnMod3d has also been part of an international model intercomparison exercise based on more complicated problems without known solutions. All tests show that RnMod3d gives results of good quality. (au)

Waste removal sequencing using ProdMod

International Nuclear Information System (INIS)

Paul, P.K.; Gregory, M.V.; Davis, N.R.; Brooke, J.N.

1996-01-01

The Savannah River Site (SRS) is starting to solidify its accumulated high-level radioactive waste into borosilicate glass in stainless steel canisters for eventual permanent storage. The in-tank precipitation process (ITP) and extended sludge processing (ESP) are two key operations in the waste processing complex. The supernate and dissolved salt from the waste storage tanks are transferred to the ITP process tank where the solution is decontaminated in batch processes. Soluble radioactive cesium is precipitated with sodium tetraphenylborate and strontium, uranium, and plutonium are adsorbed on monosodium titanate. The precipitate and adsorbent solids, which now contain the radionuclides, are concentrated using crossflow filters. The concentrated solids are sent to the high-level waste vitrification process. The decontaminated salt solution is sent to the low-level waste solidification process to form cement grout. In parallel with the precipitate operations, insoluble sludges that settled originally to the bottom of the waste tanks are reslurried and sent to ESP to undergo washing to reduce soluble salt content and aluminum dissolution, if required. In the vitrification process in the Defense Waste Processing Facility (DWPF), the concentrated precipitate from the ITP is mixed with the washed sludge from ESP and glass frit in proportion to form a stable borosilicate glass. A novel and fast-running Production Planning Model (ProdMod) has been developed to simulate the waste processing operation. This paper describes the application of ProdMod in sequencing the ITP batches and scheduling the ESP batches

Mechanical measurements in RFX-mod experiment

Energy Technology Data Exchange (ETDEWEB)

Dalla Palma, M., E-mail: mauro.dallapalma@igi.cnr.it [Consorzio RFX, EURATOM-ENEA Association, Corso Stati Uniti 4, 35127 Padova (Italy); Ravarotto, D.; Dal Bello, S.; Fincato, M.; Ghiraldelli, R.; Marchiori, G.; Taliercio, C.; Zaccaria, P. [Consorzio RFX, EURATOM-ENEA Association, Corso Stati Uniti 4, 35127 Padova (Italy)

2010-12-15

The ongoing experimental campaigns of RFX-mod are performed setting operational parameters at the nominal or exceeding design values of the experiment. Compressive forces up to 11 MN are produced by high magnetizing currents that reach values up to 50 kA. These forces heavily load the mechanical structure of RFX-mod and their effects are measured and monitored in order to assess the expected structural response and machine reliability during operation. Mechanical strains and relative displacements are real time measured during each experimental pulse by 48 strain gauges located on 12 mechanical struts and 16 potentiometers positioned between the toroidal assembly and the support mechanical structure. The strains in the most stressed components are measured by means of 24 half bridge gauges preliminarily calibrated. Particular care has been given to sensor choices and installation in order to minimize signal noises induced by the electrical and magnetic fields. The residual noises have been further reduced by proper sampling frequency and averaging techniques. The strains measured on the struts are then post-processed to calculate the resultant forces and bending moments, while the displacement measurements give an estimate of the overall stiffness of the mechanical structure. The measured forces and displacements are shown per toroidal locations and as a function of the current intensity, so verifying the uniform sharing of forces among the different struts and the proper square law correlation with the magnetizing current intensity.

Analyse géographique et modélisation des dynamiques d’urbanisation à La Réunion

Directory of Open Access Journals (Sweden)

Pascal Thinon

2007-07-01

Full Text Available Cet article propose un prototype de modèle d’interprétation des dynamiques urbaines sur l’Ile de la Réunion. En entrée, le modèle combine un ensemble de champs géographiques jouant en faveur ou en défaveur de l’urbanisation ; en sortie, il indique une propension à l’urbanisation de chaque lieu. Il est conçu de manière à permettre une analyse exploratoire de ces dynamiques selon une approche heuristique. Les premiers résultats ont permis d’obtenir, sur l’ensemble de l’île, une carte de la propension à l’urbanisation, jugée satisfaisante eu égard aux dynamiques observées entre 1989 et 2002 ; un premier scénario d’évolution, concernant les espaces de savanes à l’ouest de l’île, est également proposé. Les premiers travaux sur ce modèle, encore à un stade préliminaire, sont encourageants mais soulèvent de nombreuses questions concernant notamment le calibrage des facteurs et leur rôle respectif, l’intégration de nouveaux champs comme le voisinage, l’analyse des résidus, la mesure de la qualité du modèle ou bien encore la mobilisation de ce type de modèle comme outil d’accompagnement de projets de territoires.

Investigation of RF-enhanced plasma potentials on Alcator C-Mod

Energy Technology Data Exchange (ETDEWEB)

Ochoukov, R., E-mail: ochoukov@psfc.mit.edu [PSFC MIT, NW17, 175 Albany Street, Cambridge, MA 02139 (United States); Whyte, D.G.; Brunner, D. [PSFC MIT, NW17, 175 Albany Street, Cambridge, MA 02139 (United States); Cziegler, I. [Center for Energy Research, UCSD, 9500 Gilman Drive, La Jolla, CA 92093 (United States); LaBombard, B.; Lipschultz, B. [PSFC MIT, NW17, 175 Albany Street, Cambridge, MA 02139 (United States); Myra, J. [Lodestar Research Corporation, 2400 Central Avenue P-5, Boulder, CO 80301 (United States); Terry, J.; Wukitch, S. [PSFC MIT, NW17, 175 Albany Street, Cambridge, MA 02139 (United States)

2013-07-15

Radio frequency (RF) sheath rectification is a leading mechanism suspected of causing anomalously high erosion of plasma facing materials in RF-heated plasmas on Alcator C-Mod. An extensive experimental survey of the plasma potential (Φ{sub P}) in RF-heated discharges on C-Mod reveals that significant Φ{sub P} enhancement (>100 V) is found on outboard limiter surfaces, both mapped and not mapped to active RF antennas. Surfaces that magnetically map to active RF antennas show Φ{sub P} enhancement that is, in part, consistent with the recently proposed slow wave rectification mechanism. Surfaces that do not map to active RF antennas also experience significant Φ{sub P} enhancement, which strongly correlates with the local fast wave intensity. In this case, fast wave rectification is a leading candidate mechanism responsible for the observed enhancement.

Analyses for MARIA Research Reactor with RELAP/MOD3 code

International Nuclear Information System (INIS)

Szczurek, J.; Czerski, P.

2004-01-01

This paper deals with the application of the RELAP5/MOD3 code to the transient analyses for MARIA research reactor. Poland's MARIA Research Reactor is water and beryllium moderated, water-cooled reactor of a pool type with pressurized fuel channels containing concentric multi-tube assemblies of highly enriched uranium clad in aluminium. The RELAP5/MOD3 input data model includes the whole primary cooling circuit of the MARIA reactor. The model was qualified against the reactor data at steady state conditions and additionally against the existing reliable experimental data for a transient initiated by the reactor scram. The RELAP transient simulation was performed for loss of forced flow accidents including two scenarios with protected and unprotected (no scram) reactor core. Calculations allow estimating time margin for reactor scram initiation and reactivity feedbacks contribution to the results. (author)

Analysis of Semiscale Mod-1 integral test with asymmetrical break (Test S-29-1)

International Nuclear Information System (INIS)

Langerman, M.A.

1977-03-01

Selected experimental data obtained from Semiscale Mod-1 cold leg break Test S-29-1 and results obtained from analytical codes are analyzed. This test was the first integral blowdown reflood test conducted with the Mod-1 system and was a special test designed specifically to evaluate the sensitivity of the early Mod-1 core thermal response (0 to 5 sec after rupture) to the magnitude and direction of the core flow. To achieve this specific objective in Test S-29-1, the vessel side break area was reduced to approximately one-half the scaled break area associated with a 200 percent cold leg break test. The reduction in break area significantly reduced the core flow reversal that took place immediately after rupture and resulted in periods of positive core flow in the early portion of the test. The results obtained from this test are compared with results obtained from a 200 percent cold leg break test and the effect of core flow on early core thermal response is evaluated. Since Test S-29-1 was the first integral blowdown reflood test conducted with the Mod-1 system, data are also presented through the reflood stage of the test and the results are analyzed. The test data and the core thermal response calculated with the RELAP4 code are also compared

C-Mod Collaboration Informal Technical Progress Report

International Nuclear Information System (INIS)

Kenneth W. Gentle

2007-01-01

The aims of the collaboration have not changed. A specific list of tasks was agreed upon during the Fall of 2006 in preparation for the 2007 C-Mod campaign by Earl Marmar, Head of the Alcator Project, Kenneth Gentle, Principal Investigator, and William Rowan, Collaboration Coordinator with the facilitation of Adam Rosenberg (DOE grant monitor for the collaboration). The activities follow the list of tasks and are discussed in this progress report

Intelligence artificielle et agents collectifs : le modèle EUROSIM

Directory of Open Access Journals (Sweden)

Denise Pumain

2007-07-01

Full Text Available EUROSIM est un modèle multi-agents conçu pour simuler l’évolution à moyen terme du système des villes européennes. Les agents sont des entités collectives, les grandes villes caractérisées par leur taille et leur fonction dans le système des villes, et dont les interactions (échanges modulés par des relations de proximité ou de réseau déterminent la dynamique relative, tandis que la croissance d’ensemble dépend de l’innovation. Des outils d’analyse multiscalaire ont été développés afin d’interpréter les sorties du modèle et faciliter le calibrage.

Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

International Nuclear Information System (INIS)

Yang, S.Y.; Lan, C.B.; Chen, C.H.; Horng, H.E.; Hong, Chin-Yih; Yang, H.C.; Lai, Y.K.; Lin, Y.H.; Teng, K.S.

2009-01-01

Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

Independency of Fe ions in hemoglobin on immunomagnetic reduction assay

Energy Technology Data Exchange (ETDEWEB)

Yang, S.Y. [MagQu Co. Ltd., Sindian City, Taipei County 231, Taiwan (China); Institute of Electro-optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (China); Lan, C.B.; Chen, C.H. [Institute of Electro-optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (China); Horng, H.E. [Institute of Electro-optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (China)], E-mail: phyfv001@scc.ntnu.edu.tw; Hong, Chin-Yih [Department of Mechanical Engineering, Nan-Kai University of Technology, Nantau County, Taiwan (China)], E-mail: cyhong@nkut.edu.tw; Yang, H.C. [Department of Physics, National Taiwan University, Taipei 106, Taiwan (China)], E-mail: hcyang@phys.ntu.edu.tw; Lai, Y.K. [College of Life Sciences, National Tsing Hua University, Hsinchu City 300, Taiwan (China); Department of Bioresources, Da-Yeh University, Changhua 515, Taiwan (China); Lin, Y.H.; Teng, K.S. [Apex Biotechnology Co. Ltd., Hsinchu City 300, Taiwan (China)

2009-10-15

Immunomagnetic reduction (IMR), which involves measuring the reduction in the ac magnetic susceptibility of magnetic reagents, is due to the association between bio-functionalized magnetic nanoparticles and target bio-molecules. This has been demonstrated for assaying proteins in solutions free of Fe ions, such as serum. In this work, the validity of IMR assay for samples rich in Fe ions like hemoglobin (Hb) is investigated. According to the results, there is no magnetic signal contributed by Fe-ion-rich Hb. Furthermore, the results show a high sensitivity in assaying hemoglobin A1c (HbA1c) by using IMR.

Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 5

Science.gov (United States)

1984-01-01

The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. Detail drawings of several assemblies and subassemblies are given. This is the fifth book of volume 4.

Experiment data report for semiscale Mod-1 Test S-06-5. (LOFT counterpart test)

International Nuclear Information System (INIS)

1977-06-01

Recorded test data are presented for Test S-06-5 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-5 was conducted from initial conditions of 2272 psia and 536 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold legs of the intact and broken loops to simulate emergency core coolant injection in a PWR. The purpose of Test S-06-5 was to assess the influence of the break nozzle geometry on core thermal and system response and on the subcooled and low quality mass flow rates at the break locations

Comparison of tungsten nano-tendrils grown in Alcator C-Mod and linear plasma devices

International Nuclear Information System (INIS)

Wright, G.M.; Brunner, D.; Baldwin, M.J.; Bystrov, K.; Doerner, R.P.; Labombard, B.; Lipschultz, B.; De Temmerman, G.; Terry, J.L.; Whyte, D.G.; Woller, K.B.

2013-01-01

Growth of tungsten nano-tendrils (“fuzz”) has been observed for the first time in the divertor region of a high-power density tokamak experiment. After 14 consecutive helium L-mode discharges in Alcator C-Mod, the tip of a tungsten Langmuir probe at the outer strike point was fully covered with a layer of nano-tendrils. The depth of the W fuzz layer (600 ± 150 nm) is consistent with an empirical growth formula from the PISCES experiment. Re-creating the C-Mod exposures as closely as possible in Pilot-PSI experiment can produce nearly-identical nano-tendril morphology and layer thickness at surface temperatures that agree with uncertainties with the C-Mod W probe temperature data. Helium concentrations in W fuzz layers are measured at 1–4 at.%, which is lower than expected for the observed sub-surface voids to be filled with several GPa of helium pressure. This possibly indicates that the void formation is not pressure driven

Experiment data report for Semiscale Mod-1 Test S-05-5 (alternate ECC injection test)

International Nuclear Information System (INIS)

Collins, B.L.; Patton, M.L. Jr.; Sackett, K.E.

1977-04-01

Recorded test data are presented for Test S-05-5 of the Semiscale Mod-1 alternate ECC injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-5 was conducted from initial conditions of 2263 psia and 537 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. The upper plenum was vented through a reflood bypass line interconnecting the hot and cold legs of the broken loop

Relap5/mod2 post-test calculation of a loss of feedwater experiment at the Pactel test facility

Energy Technology Data Exchange (ETDEWEB)

Protze, M. [Siemens-KWU, Erlangen (Germany)

1995-12-31

Post-test calculations for verification purposes of the thermal hydraulic code RELAP5/MOD2 are of fundamental importance for the licensing procedure. The RELAP5/MOD2 code has a large international assessment base regarding western PWR. WWER-reactors are russian designed PWRs with some specific differences compared with the western PWR`s, especially the horizontal steam generators. For that reason some post-test calculations have to be performed to verify the RELAP5/MOD2 code for these WWER typical phenomena. The impact of the horizontal steam generators on the accident behaviour during transients or pipe ruptures on the secondary side is significant. The nodalization of the test facility PACTEL was chosen equally to WWER plant nodalization to verify the use of a coarse modelling of the steam generator secondary side for analyses of transient with decreasing water level in the SG secondary side. The calculational results showed a good compliance to the test results, demonstrating the correct use of a coarse nodalization. To sum up, the RELAP5/ MOD2 results met the test results appropriately thereby the RELAP5/ MOD2 code is validated for analyses of transients with decreasing water level in a horizontal steam generator secondary side. (orig.). 4 refs.

Relap5/mod2 post-test calculation of a loss of feedwater experiment at the Pactel test facility

Energy Technology Data Exchange (ETDEWEB)

Protze, M [Siemens-KWU, Erlangen (Germany)

1996-12-31

Post-test calculations for verification purposes of the thermal hydraulic code RELAP5/MOD2 are of fundamental importance for the licensing procedure. The RELAP5/MOD2 code has a large international assessment base regarding western PWR. WWER-reactors are russian designed PWRs with some specific differences compared with the western PWR`s, especially the horizontal steam generators. For that reason some post-test calculations have to be performed to verify the RELAP5/MOD2 code for these WWER typical phenomena. The impact of the horizontal steam generators on the accident behaviour during transients or pipe ruptures on the secondary side is significant. The nodalization of the test facility PACTEL was chosen equally to WWER plant nodalization to verify the use of a coarse modelling of the steam generator secondary side for analyses of transient with decreasing water level in the SG secondary side. The calculational results showed a good compliance to the test results, demonstrating the correct use of a coarse nodalization. To sum up, the RELAP5/ MOD2 results met the test results appropriately thereby the RELAP5/ MOD2 code is validated for analyses of transients with decreasing water level in a horizontal steam generator secondary side. (orig.). 4 refs.

BioJava-ModFinder: identification of protein modifications in 3D structures from the Protein Data Bank.

Science.gov (United States)

Gao, Jianjiong; Prlic, Andreas; Bi, Chunxiao; Bluhm, Wolfgang F; Dimitropoulos, Dimitris; Xu, Dong; Bourne, Philip E; Rose, Peter W

2017-07-01

We developed a new software tool, BioJava-ModFinder, for identifying protein modifications observed in 3D structures archived in the Protein Data Bank (PDB). Information on more than 400 types of protein modifications were collected and curated from annotations in PDB, RESID, and PSI-MOD. We divided these modifications into three categories: modified residues, attachment modifications, and cross-links. We have developed a systematic method to identify these modifications in 3D protein structures. We have integrated this package with the RCSB PDB web application and added protein modification annotations to the sequence diagram and structure display. By scanning all 3D structures in the PDB using BioJava-ModFinder, we identified more than 30 000 structures with protein modifications, which can be searched, browsed, and visualized on the RCSB PDB website. BioJava-ModFinder is available as open source (LGPL license) at ( https://github.com/biojava/biojava/tree/master/biojava-modfinder ). The RCSB PDB can be accessed at http://www.rcsb.org . pwrose@ucsd.edu. © The Author 2017. Published by Oxford University Press.

Analysis of the VVER-440 reactor steam generator secondary side with the RELAP5/MOD3 code

International Nuclear Information System (INIS)

Tuunanen, J.

1993-01-01

Nuclear Engineering Laboratory of the Technical Research Centre of Finland has widely used RELAP5/MOD2 and -MOD3 codes to simulate horizontal steam generators. Several models have been developed and successfully used in the VVER-safety analysis. Nevertheless, the models developed have included only rather few nodes in the steam generator secondary side. The secondary side has normally been divided into about 10 to 15 nodes. Since the secondary side at the steam generators of VVER-440 type reactors consists of a rather large water pool, these models were only roughly capable to predict secondary side flows. The paper describes an attempt to use RELAP5/MOD3 code to predict secondary side flows in a steam generator of a VVER-440 reactor. A 2D/3D model has been developed using RELAP5/MOD3 codes cross-flow junctions. The model includes 90 volumes on the steam generator secondary side. The model has been used to calculate steady state flow conditions in the secondary side of a VVER-440 reactor steam generator. (orig.) (1 ref., 9 figs., 2 tabs.)

Conception d’un automate cellulaire non stationnaire à base de graphe pour modéliser la structure spatiale urbaine: le modèle Remus

Directory of Open Access Journals (Sweden)

Arnaud Banos

2007-10-01

Full Text Available Nous proposons dans cet article une formalisation originale des automates cellulaires géographiques, à même de mieux prendre en compte grâce à une structure de graphe le voisinage irrégulier et dynamique d’entités spatiales. Le modèle Remus permet ainsi de représenter sous la forme d’un graphe mathématique les entités spatiales du bâti et les réseaux de transport urbain (graphe urbain ; il permet aussi de calculer la distance-temps entre bâtiments par le réseau. Le modèle Remus permet l’extraction de différents graphes, dont le graphe fonctionnel des distances-temps entre les immeubles et le graphe de relations de voisinage qui représente le voisinage par le réseau pour un certain seuil de temps de trajet et pour un mode de transport donné.

Numerical modelling of ICRF physics experiments in the Alcator C-mod tokamak

International Nuclear Information System (INIS)

Bonoli, P.T.; Boivin, R.L.; Brambilla, M.

2001-01-01

A full-wave spectral code (TORIC) has been used to simulate mode converted ion Bernstein wave (IBW) propagation and absorption for the first time at high poloidal mode number (-80< m<+80). Converged wave solutions for the mode converted wave are obtained in this limit and the predicted electron damping of the IBW is found to be consistent with experimental measurements from the Alcator C-Mod tokamak. The TORIC code has also been coupled to a bounce-averaged Fokker Planck module FPPRF and the combined codes are now run within the transport analysis tool TRANSP. This model was used to analyze off-axis hydrogen minority heating experiments in C-Mod where an internal transport barrier was obtained. (author)

Antimicrobial Disk Susceptibility Testing of Leptospira spp. Using Leptospira Vanaporn Wuthiekanun (LVW) Agar.

Science.gov (United States)

Wuthiekanun, Vanaporn; Amornchai, Premjit; Langla, Sayan; White, Nicholas J; Day, Nicholas P J; Limmathurotsakul, Direk; Peacock, Sharon J

2015-08-01

Leptospira Vanaporn Wuthiekanun (LVW) agar was used to develop a disk diffusion assay for Leptospira spp. Ten pathogenic Leptospira isolates were tested, all of which were susceptible to 17 antimicrobial agents (amoxicillin/clavulanic acid, amoxicillin, azithromycin, cefoxitin, ceftazidime, ceftriaxone, chloramphenicol, ciprofloxacin, clindamycin, doripenem, doxycycline, gentamicin, linezolid, nitrofurantoin, penicillin, piperacillin/tazobactam, and tetracycline). All 10 isolates had no zone of growth inhibition for four antimicrobials (fosfomycin, nalidixic acid, rifampicin, and trimethoprim/sulfamethoxazole). Of the ten Leptospira, seven had a growth inhibition zone of ≤ 21 mm for aztreonam, the zone diameter susceptibility break point for Enterobacteriaceae. This assay could find utility as a simple screening method during the epidemiological surveillance of antimicrobial resistance in Leptospira spp. © The American Society of Tropical Medicine and Hygiene.

Experiment data report for Semiscale Mod-1 Test S-05-4 (alternate ECC injection test)

International Nuclear Information System (INIS)

Collins, B.L.; Feldman, E.M.

1977-03-01

Recorded test data are presented for Test S-05-4 of the Semiscale Mod-1 alternate emergency core coolant injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-4 was conducted from initial conditions of 2266 psia and 543 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the cold leg of each loop and into the vessel upper plenum to simulate emergency core coolant injection in a PWR. The upper plenum coolant injection was scaled according to the heat stored in the metal mass of the upper plenum

Progress on MOD/RABiTSTM 2G HTS wire

International Nuclear Information System (INIS)

Rupich, M.W.; Zhang, W.; Li, X.; Kodenkandath, T.; Verebelyi, D.T.; Schoop, U.; Thieme, C.; Teplitsky, M.; Lynch, J.; Nguyen, N.; Siegal, E.; Scudiere, J.; Maroni, V.; Venkataraman, K.; Miller, D.; Holesinger, T.G.

2004-01-01

The development of the second generation (2G) high temperature superconducting wire has advanced beyond initial laboratory demonstrations and is now focused on developing and testing high critical current conductor designs required for commercial applications. The approach pursued at American Superconductor for 2G wire manufacturing is based on the combination of the RABiTS TM substrate-buffer technology with metal organic deposition (MOD) of the YBCO layer. This MOD/RABiTS TM approach has been demonstrated in 10 m lengths with critical currents of up to 184 A/cm-width (∼2.3 MA/cm 2 ) and in short length with critical currents of up to 270 A/cm-width (∼3.4 MA/cm 2 ). In addition to a high critical current, the superconducting wire must also meet stringent mechanical and electrical stability requirements that vary by application. Commercially viable architectures designed to meet these specifications have been fabricated and tested. Wires manufactured by this process have been successfully tested in prototype cable and coil applications

TRAC-PF1/MOD2 best-estimate analysis of a large-break LOCA in a 15 x 15 generic four-loop Westinghouse nuclear power plant

International Nuclear Information System (INIS)

Spore, J.W.; Lin, J.C.; Schnurr, N.M.; White, J.R.; Cappiello, M.C.

1992-01-01

Calculations of a large-break loss-of-coolant accident (LOCA) in a 15 x 15 generic four-loop Westinghouse nuclear power plant with both the TRAC-PF1/MOD1 and TRAC-PF1/MOD2 computer codes will be presented. The Transient Reactor Analysis Code (TRAC) has been developed by Los Alamos National Laboratory to provide advanced best-estimate simulations of real postulated transients in pressurized light-water reactors (LWRs) and for many related thermal-hydraulic facilities. The latest released version of TRAC is TRAC-PF1/MOD2. Significant improvements and enhancements over the MOD1 version were implemented in the MOD2 heat-transfer and constitutive models. One of the most significant improvements in the MOD2 code has been the implementation of the two-step numerics method in the three-dimensional components, which can significantly reduce run times for long, slow transients. A very important area of improvement has been in the reflood heat-transfer models. Developmental assessment results (i.e., code comparisons with experimental data) will be discussed for several separate-effects and integral test, including analysis of the Upper Plenum Test Facility (UPTF), the Cylindrical Core Test Facility (CCTF), and the Loss-of-Fluid Test Facility (LOFT). The assessment results provide information on the anticipated accuracy for the best-estimate models in the MOD2 computer code. The MOD1 to MOD2 comparison will provide an estimate for the effect of improved heat-transfer models on predicted peak cladding temperatures

Evaporation in porous media modelling :fundamental and applied models development /Modélisation de l'évaporation en milieu poreux :développement de modèles fondamentaux et appliqués

OpenAIRE

Debaste, Frédéric

2008-01-01

L'étude des phénomènes fondamentaux de transport et de thermodynamique apparaissant lors de l'évaporation en milieu poreux permet l'investigation d'applications pratiques variées. Dans ce travail, nous développons des modèles fondamentaux d'évaporation en milieu poreux que nous appliquons ensuite au séchage en lit fluidisé de deux matériaux granulaires poreux :le PVC et la levure. Les modèles mis au point sont réalisés suivant une approche multiéchelle. Nous nous intér...

Mod-5A wind turbine generator program design report. Volume 3: Final design and system description, book 1

Science.gov (United States)

1984-01-01

The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. Volume 3, book 1 describes the performance and characteristics of the MOD-5A wind turbine generator in its final configuration. Each subsystem - the rotor, drivetrain, nacelle, tower and foundation is described in detail.

Assessment of TRAC-PF1/MOD1 code for large break LOCA in PWR

International Nuclear Information System (INIS)

Akimoto, Hajime; Ohnuki, Akira; Murao, Yoshio; Abe, Yutaka.

1993-03-01

As the first step of the REFLA/TRAC code development, the TRAC/PF1/MOD1 code has been assessed for various experiments that simulate postulated large-break loss-of-coolant accident (LBLOCA) in PWR to understand the predictive capability and to identify the problem areas of the code. The assessment calculations were performed for separate effect tests for critical flow, counter current flow, condensation at cold leg and reflood as well as integral tests to understand predictability for individual phenomena. This report summarizes results from the assessment calculations of the TRAC-PF1/MOD1 code for LBLOCA in PWR. The assessment calculations made clear the predictive capability and problem areas of the TRAC-PF1/MOD1 code for LBLOCA in PWR. The areas, listed below, should be improved for more realistic and effective simulation of LBLOCA in PWR: (1) core heat transfer model during blowdown, (2) ECC bypass model at downcomer during refill, (3) condensation model during accumulator injection, and (4) core thermal hydraulic model during reflood. (author) 57 refs

Prise en compte des ``courants de London'' dans la modélisation des supraconducteurs

Science.gov (United States)

Bossavit, Alain

1997-10-01

A model is given, in variational form, in which volumic “Bean currents”, ruled by Bean's law, and surface “London currents” coexist. This macroscopic model generalizes Bean's one, by appending to the critical density j_c a second parameter, with the dimension of a length, similar to London's depth λ. The one-dimensional version of the model is investigated, in order to link this parameter with the standard observable H-M characteristics On propose un modèle, sous forme variationnelle, associant des “courants de Bean” volumiques, décrits par la loi de Bean, et des “courants de London”, surfaciques. Ce modèle macroscopique généralise celui de Bean, caractérisé par le courant critique j_c, et fait intervenir un second paramètre, homogène à une longueur, analogue au λ de London. La version unidimensionnelle du modèle est étudiée en détail de manière à relier ce paramètre à l'observation des caractéristiques H-M usuelles.

Posttest analysis of international standard problem 10 using RELAP4/MOD7

International Nuclear Information System (INIS)

Hsu, M.; Davis, C.B.; Peterson, A.C. Jr.; Behling, S.R.

1981-01-01

RELAP4/MOD7, a best estimate computer code for the calculation of thermal and hydraulic phenomena in a nuclear reactor or related system, is the latest version in the RELAP4 code development series. This paper evaluates the capability of RELAP4/MOD7 to calculate refill/reflood phenomena. This evaluation uses the data of International Standard Problem 10, which is based on West Germany's KWU PKL refill/reflood experiment K9A. The PKL test facility represents a typical West German four-loop, 1300 MW pressurized water reactor (PWR) in reduced scale while maintaining prototypical volume-to-power ratio. The PKL facility was designed to specifically simulate the refill/reflood phase of a hypothetical loss-of-coolant accident

Background and system description of the Mod 1 wind turbine generator

Science.gov (United States)

Ernst, E. H.

1978-01-01

The Mod-1 wind turbine considered is a large utility-class machine, operating in the high wind regime, which has the potential for generation of utility grade power at costs competitive with other alternative energy sources. A Mod-1 wind turbine generator (WTG) description is presented, taking into account the two variable-pitch steel blades of the rotor, the drive train, power generation/control, the Nacelle structure, and the yaw drive. The major surface elements of the WTG are the ground enclosure, the back-up battery system, the step-up transformer, elements of the data system, cabling, area lighting, and tower foundation. The final system weight (rotor, Nacelle, and tower) is expected to be about 650,000 pounds. The WTG will be capable of delivering 1800 kW to the utility grid in a wind-speed above 25 mph.

Experiment data report for Semiscale Mod-1 Test S-05-3 (alternate ECC injection test)

International Nuclear Information System (INIS)

Feldman, E.M.; Patton, M.L. Jr.; Sackett, K.E.

1977-03-01

Recorded test data are presented for Test S-05-3 of the Semiscale Mod-1 alternate ECC injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-3 was conducted from initial conditions of 2263 psia and 545 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the cold leg sides of the intact and broken loops and into the vessel upper plenum to simulate emergency core coolant injection in a PWR. For Test S-05-3, specifically the effects of upper plenum coolant injection on core thermal and system response were being investigated

Pulsed klystrons with feedback controlled mod-anode modulators

Energy Technology Data Exchange (ETDEWEB)

Reass, William A [Los Alamos National Laboratory; Baca, David M [Los Alamos National Laboratory; Jerry, Davis L [Los Alamos National Laboratory; Rees, Daniel E [Los Alamos National Laboratory

2009-01-01

This paper describes a fast rise and fall, totem-pole mod-anode modulators for klystron application. Details of these systems as recently installed utilizing a beam switch tube ''on-deck'' and a planar triode ''off-deck'' in a grid-catch feedback regulated configuration will be provided. The grid-catch configuration regulates the klystron mod-anode voltage at a specified set-point during switching as well as providing a control mechanism that flat-top regulates the klystron beam current during the pulse. This flat-topped klystron beam current is maintained while the capacitor bank droops. In addition, we will review more modern on-deck designs using a high gain, high voltage planar triode as a regulating and switching element. These designs are being developed, tested, and implemented for the Los Alamos Neutron Science Center (LANSCE) accelerator refurbishment project, ''LANSCE-R''. An advantage of the planar triode is that the tube can be directly operated with solid state linear components and provides for a very compact design. The tubes are inexpensive compared to stacked semiconductor switching assemblies and also provide a linear control capability. Details of these designs are provided as well as operational and developmental results.

GalMod: the last frontier of Galaxy population synthesis models

Science.gov (United States)

Pasetto, Stefano; Kollmeier, Juna; Grebel, Eva K.; chiosi, cesare

2018-01-01

We present a novel Galaxy population synthesis model: GalMod (Pasetto et al. 2016, 2017a,b) is the only star-count model featuring an asymmetric bar/bulge as well as spiral arms as directly obtained by applying linear perturbative theory to self-consistent distribution function of the Galaxy stellar populations. Compared to previous literature models (e.g., Besancon, Trilegal), GalMod allows to generate full-sky mock catalogue, M31 surveys and provides a better match to observed Milky Way (MW) stellar fields.The model can generate synthetic mock catalogs of visible portions of the MW, external galaxies like M31, or N-body simulation initial conditions. At any given time, e.g., a chosen age of the Galaxy, the model contains a sum of discrete stellar populations, namely bulge/bar, disk, halo. The disk population is itself the sum of subpopulations: spiral arms, thin disk, thick disk, and gas component, while the halo is modeled as the sum of a stellar component, a hot coronal gas, and a dark matter component. The Galactic potential is computed from these subpopulations' density profiles and used to generate detailed kinematics by considering the first few moments of the Boltzmann collisionless equation for all the stellar subpopulations. The same density profiles are then used to define the observed color-magnitude diagrams within an input field of view from an arbitrary solar location. Several photometric systems have been included and made available on-line, e.g., SDSS, Gaia, 2MASS, HST WFC3, and others. Finally, we model the extinction with advanced ray tracing solutions.The model's web page (and tutorial) can be accessed at www.GalMod.org.

Code Development and Analysis Program: developmental checkout of the BEACON/MOD2A code

International Nuclear Information System (INIS)

Ramsthaler, J.A.; Lime, J.F.; Sahota, M.S.

1978-12-01

A best-estimate transient containment code, BEACON, is being developed by EG and G Idaho, Inc. for the Nuclear Regulatory Commission's reactor safety research program. This is an advanced, two-dimensional fluid flow code designed to predict temperatures and pressures in a dry PWR containment during a hypothetical loss-of-coolant accident. The most recent version of the code, MOD2A, is presently in the final stages of production prior to being released to the National Energy Software Center. As part of the final code checkout, seven sample problems were selected to be run with BEACON/MOD2A

Quality Assurance Procedures for ModCat Database Code Files

Energy Technology Data Exchange (ETDEWEB)

Siciliano, Edward R.; Devanathan, Ram; Guillen, Zoe C.; Kouzes, Richard T.; Schweppe, John E.

2014-04-01

The Quality Assurance procedures used for the initial phase of the Model Catalog Project were developed to attain two objectives, referred to as “basic functionality” and “visualization.” To ensure the Monte Carlo N-Particle model input files posted into the ModCat database meet those goals, all models considered as candidates for the database are tested, revised, and re-tested.

Countercurrent flow limitation model for RELAP5/MOD3

International Nuclear Information System (INIS)

Riemke, R.A.

1991-01-01

This paper reports on a countercurrent flow limitation model incorporated into the RELAP5/MOD3 system transient analysis code. The model is implemented in a manner similar to the RELAP5 chocking model. Simulations using air/water flooding test problem demonstrate the ability of the code to significantly improve its comparison to data when a flooding correlation is used

TRAC-PF1/MOD 1 independent assessment: Semiscale MOD-2A feedwater-line break (S-SF-3) and steam-line break (S-SF-5) tests

International Nuclear Information System (INIS)

Dobranich, D.

1985-11-01

The TRAC-PF1/MOD1 independent assessment project at Sandia is part of an overall effort funded by the NRC to determine the ability of various systems codes to predict the detailed thermal/hydraulic response of LWRs during accident and off-normal conditions. As part of this effort, calculations for Semiscale Mod-2A test S-SF-3, a feedwater-line break test, and S-SF-5, a steam-line break test, were performed with TRAC-PF1/MOD1. Most aspects of both the S-SF-3 and S-SF-5 steady-state calculations were found to be in good agreement with data. However, the need for a better steam separator model was identified from the S-SF-3 calculation. Overall, the qualitative behavior of both transients was calculated reasonably well; however, there were some discrepancies in the prediction of the quantitative behavior. The results for the S-SF-3 transient calculation indicate that the primary-to-secondary heat transfer degradation began too early. This was possibly due to overprediction of entrainment in the steam generator boiler, leading to an incorrect calculation of the secondary-side fluid distribution during the steady state. However, there was insufficient data to verify this. Results for the S-SF-5 transient calculation indicate that the primary-side fluid temperature response to a steam-line break was in reasonable agreement with data but the pressure response did not coincide with the data. Uncertainties in the data are sufficient to prevent us from determining the exact cause of this discrepancy, but there is indirect evidence that the calculated rate of phase change in the pressurizer was incorrect. 16 refs., 73 figs., 13 tabs

Antimicrobial susceptibility patterns of Brazilian Haemophilus parasuis field isolates

Directory of Open Access Journals (Sweden)

Michela Miani

Full Text Available ABSTRACT: Haemophilus parasuis is the etiological agent of Glässer’s disease (GD, an ubiquitous infection of swine characterized by systemic fibrinous polyserositis, polyarthritis and meningitis. Intensive use of antimicrobial agents in swine husbandries during the last years triggered the development of antibiotic resistances in bacterial pathogens. Thus, regular susceptibility testing is crucial to ensure efficacy of different antimicrobial agents to this porcine pathogen. In this study, 50 clinical isolates from South Brazilian pig herds were characterized and analyzed for their susceptibility to commonly used antibiotic. The identification and typing of clinical isolates was carried out by a modified indirect hemagglutination assay combined with a multiplex PCR. The susceptibility of each isolate was analyzed by broth microdilution method against a panel of 21 antimicrobial compounds. We found that field isolates are highly resistance to gentamycin, bacitracin, lincomycin and tiamulin, but sensitive to ampicillin, clindamycin, neomycin, penicillin, danofloxacin and enrofloxacin. Furthermore, an individual susceptibility analysis indicated that enrofloxacin is effective to treat clinical isolates with the exception of those classified as serovar 1. The results presented here firstly demonstrate the susceptibility of Brazilian clinical isolates of H. parasuis to antimicrobials widely used by swine veterinary practitioners and strengthen the need to perform susceptibility test prior to antibiotic therapy during GD outbreaks. In addition, because only six antimicrobial drugs (28.6% were found effective against field isolates, a continuous surveillance of the susceptibility profile should be of major concern to the swine industry.

Testing Gyrokinetics on C-Mod and NSTX

International Nuclear Information System (INIS)

Redi, M.H.; Dorland, W.; Fiore, C.L.; Stutman, D.; Baumgaertel, J.A.; Davis, B.; Kaye, S.M.; McCune, D.C.; Menard, J.; Rewoldt, G.

2005-01-01

Quantitative benchmarks of computational physics codes against experiment are essential for the credible application of such codes. Fluctuation measurements can provide necessary critical tests of nonlinear gyrokinetic simulations, but such require extraordinary computational resources. Linear micro-stability calculations with the GS2 [1] gyrokinetic code have been carried out for tokamak and ST experiments which exhibit internal transport barriers (ITB) and good plasma confinement. Qualitative correlation is found for improved confinement before and during ITB plasmas on Alcator C-Mod [2] and NSTX [3], with weaker long wavelength micro-instabilities in the plasma core regions. Mixing length transport models are discussed. The NSTX L-mode is found to be near marginal stability for kinetic ballooning modes. Fully electromagnetic, linear, gyrokinetic calculations of the Alcator C-Mod ITB during off-axis rf heating, following four plasma species and including the complete electron response show ITG/TEM microturbulence is suppressed in the plasma core and in the barrier region before barrier formation, without recourse to the usual requirements of velocity shear or reversed magnetic shear [4-5]. No strongly growing long or short wavelength drift modes are found in the plasma core but strong ITG/TEM and ETG drift wave turbulence is found outside the barrier region. Linear microstability analysis is qualitatively consistent with the experimental transport analysis, showing low transport inside and high transport outside the ITB region before barrier formation, without consideration of ExB shear stabilization

Identification of functional elements and regulatory circuits by Drosophila modENCODE

Energy Technology Data Exchange (ETDEWEB)

Roy, Sushmita; Ernst, Jason; Kharchenko, Peter V.; Kheradpour, Pouya; Negre, Nicolas; Eaton, Matthew L.; Landolin, Jane M.; Bristow, Christopher A.; Ma, Lijia; Lin, Michael F.; Washietl, Stefan; Arshinoff, Bradley I.; Ay, Ferhat; Meyer, Patrick E.; Robine, Nicolas; Washington, Nicole L.; Stefano, Luisa Di; Berezikov, Eugene; Brown, Christopher D.; Candeias, Rogerio; Carlson, Joseph W.; Carr, Adrian; Jungreis, Irwin; Marbach, Daniel; Sealfon, Rachel; Tolstorukov, Michael Y.; Will, Sebastian; Alekseyenko, Artyom A.; Artieri, Carlo; Booth, Benjamin W.; Brooks, Angela N.; Dai, Qi; Davis, Carrie A.; Duff, Michael O.; Feng, Xin; Gorchakov, Andrey A.; Gu, Tingting; Henikoff, Jorja G.; Kapranov, Philipp; Li, Renhua; MacAlpine, Heather K.; Malone, John; Minoda, Aki; Nordman, Jared; Okamura, Katsutomo; Perry, Marc; Powell, Sara K.; Riddle, Nicole C.; Sakai, Akiko; Samsonova, Anastasia; Sandler, Jeremy E.; Schwartz, Yuri B.; Sher, Noa; Spokony, Rebecca; Sturgill, David; van Baren, Marijke; Wan, Kenneth H.; Yang, Li; Yu, Charles; Feingold, Elise; Good, Peter; Guyer, Mark; Lowdon, Rebecca; Ahmad, Kami; Andrews, Justen; Berger, Bonnie; Brenner, Steven E.; Brent, Michael R.; Cherbas, Lucy; Elgin, Sarah C. R.; Gingeras, Thomas R.; Grossman, Robert; Hoskins, Roger A.; Kaufman, Thomas C.; Kent, William; Kuroda, Mitzi I.; Orr-Weaver, Terry; Perrimon, Norbert; Pirrotta, Vincenzo; Posakony, James W.; Ren, Bing; Russell, Steven; Cherbas, Peter; Graveley, Brenton R.; Lewis, Suzanna; Micklem, Gos; Oliver, Brian; Park, Peter J.; Celniker, Susan E.; Henikoff, Steven; Karpen, Gary H.; Lai, Eric C.; MacAlpine, David M.; Stein, Lincoln D.; White, Kevin P.; Kellis, Manolis

2010-12-22

To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. We have generated more than 700 data sets and discovered protein-coding, noncoding, RNA regulatory, replication, and chromatin elements, more than tripling the annotated portion of the Drosophila genome. Correlated activity patterns of these elements reveal a functional regulatory network, which predicts putative new functions for genes, reveals stage- and tissue-specific regulators, and enables gene-expression prediction. Our results provide a foundation for directed experimental and computational studies in Drosophila and related species and also a model for systematic data integration toward comprehensive genomic and functional annotation. Several years after the complete genetic sequencing of many species, it is still unclear how to translate genomic information into a functional map of cellular and developmental programs. The Encyclopedia of DNA Elements (ENCODE) (1) and model organism ENCODE (modENCODE) (2) projects use diverse genomic assays to comprehensively annotate the Homo sapiens (human), Drosophila melanogaster (fruit fly), and Caenorhabditis elegans (worm) genomes, through systematic generation and computational integration of functional genomic data sets. Previous genomic studies in flies have made seminal contributions to our understanding of basic biological mechanisms and genome functions, facilitated by genetic, experimental, computational, and manual annotation of the euchromatic and heterochromatic genome (3), small genome size, short life cycle, and a deep knowledge of development, gene function, and chromosome biology. The functions

L’essai de la modélisation systématique de la transformation de l’espace et les modèles numériques prédictifs dans la géographie physique

Directory of Open Access Journals (Sweden)

Andrei-Emil BRICIU

2009-06-01

Full Text Available Dans cet article nous présentons les principes (géographique et informatique qui ont développé un modèledynamique des Collines de Tutova à l’aide du logiciel SpaCelle: on a une carte dynamique quiessaie (à partir d’une combinaison d'aléatoire et de déterminisme stricte, donc à partir d’unedérivation locale de la théorie du chaos de représenter l'évolution de la morphohydrographiedes Collines de Tutova depuis le Méotien jusqu'à l'Holocène. La prise en compte du temps nonseulement en tant que facteur abstrait ou coordonné, mais en tant qu’expression directe del'espace, impose une méthode géographique qui présente de nombreux potentiels.Des recherches récentes, faites en Roumanie ou à l'étranger, ont mis en évidencel'émergence d'un nouveau type d'analyse géographique. Il s’agit d’une analyse moins connue,une analyse spatio-temporelle qui traite de la dynamique des phénomènes géographiques. Elleutilise des automates cellulaires divers, tels que CAESAR (The Cellular AutomatonEvolutionary Slope And River model pour créer des modèles numériques de l'évolution quiprennent en compte un élément essentiel: le temps. Les modèles numériques standards enRoumanie sont statiques et, même s’ils présentent les différentes étapes d'un lieu, ces étapesne sont pas liées entre elles par un énoncé déterministe et continu.Nous avons utilisé l‘automate cellulaire SpaCelle v4.0 développé par Langlois (2000 dansle cadre du Laboratoire MTG, Université de Rouen. On a obtenu un modèle dynamique durelief. Nous avons adopté l’appellation de MNP (Modèle Numérique Prédictif pour ce modèleparce que, même si c’est le dynamisme qui caractérise les paramètres, ce dynamisme estsimplement le résultat des hypothèses et des perspectives théoriques. Ce qu’on vise par un telmodèle c’est l’identification des caractéristiques de l'évolution à partir d'un point de vuethéorique ou d'un autre, le

Experiment data report for Semiscale Mod-1 test S-28-3 (steam generator tube rupture test)

International Nuclear Information System (INIS)

Gillins, R.L.; Sackett, K.E.

1977-10-01

Recorded test data are presented for Test S-28-3 of the Semiscale Mod-1 steam generator tube rupture test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-28-3 was conducted from initial conditions of 15621 kPa and 555 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. Twelve steam generator tube ruptures were simulated by a controlled injection from a heated accumulator into the intact loop hot leg

Experiment data report for semiscale Mod-1 test S-28-2 (steam generator tube rupture test)

International Nuclear Information System (INIS)

Patton, M.L.; Sackett, K.E.

1977-10-01

Recorded test data are presented for Test S-28-2 of the Semiscale Mod-1 steam generator tube rupture test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-28-2 was conducted from initial conditions of 15 936 kPa and 558 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. For Test S-28-2, accumulator injection into the intact loop hot leg was provided to simulate simulate the rupture of six steam generator tubes

Experiment data report for semiscale Mod-1 test S-28-4 (steam generator tube rupture test)

International Nuclear Information System (INIS)

Esparza, V.; Sackett, K.E.

1977-10-01

Recorded test data are presented for Test S-28-4 of the Semiscale Mod-1 steam generator tube rupture test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-28-4 was conducted from initial conditions of 15 646 kPa and 557 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. Thirty steam generator tube ruptures were simulated by a controlled injection from a heated accumulator into the intact loop hot leg

Code option guideline improvement using comparisons of RELAP4/MOD6 with forced and gravity-feed reflood data. [PWR

Energy Technology Data Exchange (ETDEWEB)

Chen, T H; Fletcher, C D

1978-09-01

Improved guidelines are developed for the selection of RELAP4/MOD6 reflood heat transfer options. The development, involving modifications to the original guidelines, assessed the effect of those modifications on RELAP4/MOD6 data comparisons using previously analyzed reflood experiments. The report also presents an evaluation of the application of the revised guidelines. Data comparisons between RELAP4/MOD6, using the original and revised guidelines, and experimental data are presented for Semiscale and FLECHT, forced-feed reflood tests and Semiscale and FLECHT-SET gravity-feed reflood tests. Because a general improvement was evident in data comparisons using the revised guidelines, their use is recommended in future calculations.

Orbit Representations from Linear mod 1 Transformations

Directory of Open Access Journals (Sweden)

Carlos Correia Ramos

2012-05-01

Full Text Available We show that every point $x_0in [0,1]$ carries a representationof a $C^*$-algebra that encodes the orbit structure of thelinear mod 1 interval map $f_{eta,alpha}(x=eta x +alpha$. Such $C^*$-algebra is generated by partial isometries arising from the subintervals of monotonicity of the underlying map $f_{eta,alpha}$. Then we prove that such representation is irreducible. Moreover two such of representations are unitarily equivalent if and only if the points belong to the same generalized orbit, for every $alphain [0,1[$ and $etageq 1$.

Conceptual design Alcator C-MOD magnetic systems

International Nuclear Information System (INIS)

Schultz, J.H.; Becker, H.; Fertl, K.; Gwinn, D.; Montgomery, D.B.; Pierce, N.T.; Pillsbury, R.D. Jr.; Thome, R.J.

1986-01-01

The conceptual designs of the magnetic systems for Alcator C-MOD, a proposed tokamak at M.I.T., are described, including the toroidal magnet, the poloidal field coils and the cryogenic system. The toroidal magnet is constructed from rectangular plates, connected by sliding joints. Toroidal magnet forces are contained by a steel superstructure. Poloidal coil system options are largely or wholly inside the TF magnet, in order to control plasmas with high current, strong shaping, and expanded boundaries. All magnets are cryocooled by the natural circulation of boiling liquid nitrogen. 3 refs., 5 figs

Apport de la simulation numérique à la compréhension des mécanismes d'interaction de cavités dans le cadre de la modélisation de l'endommagement ductile sous sollicitation dynamique

Science.gov (United States)

Roy, G.; Buy, F.; Llorca, F.

2002-12-01

L'étude présentée s'inscrit dans le cadre d'une démarche menant à la construction d'un modèle analytique ou semi analytique de comportement élasto-visco-plastique endommageable, applicable aux chargements rencontrés en configuration d'impact violent et générant de l'écaillage ductile. La prise en compte des effets de compressibilité et de micro inertie est essentielle pour modéliser la phase de croissance. Des simulations numériques globales de la structure et locales à l'échelle des hétérogénéités permettent d'évaluer les niveaux de sollicitations dans les zones susceptibles de s'endommager, dévaluer des critères analytiques de germination de l'endommagement et de comprendre les mécanismes d'interaction entre les défauts. Les effets micro inertiels et de compressibilité sont ainsi mis en évidence dans les phases de germination et de coalescence des micro défauts. II s'agit ici d'une illustration non exhaustive de travaux engagés au CEA Valduc sur le tantale, dans le cadre d'une thèse [10]. Un programme matériaux en partenariat CEA-CNRS sur la modélisation multi échelles du comportement de structures a également été initié dans ce contexte.

Comparative susceptibility of veliger larvae of four bivalve mollusks to a Vibrio alginolyticus strain.

Science.gov (United States)

Luna-González, A; Maeda-Martínez, A N; Sainz, J C; Ascencio-Valle, F

2002-06-03

The susceptibility of 7 d old veliger larvae of the scallops Argopecten ventricosus and Nodipecten subnodosus, the penshell Atrina maura, and the Pacific oyster Crassostrea gigas to a pathogenic strain of Vibrio alginolyticus was investigated by challenging the larvae with different bacterial concentrations in a semi-static assay. The results indicate that the larvae of the 2 scallop species are more susceptible to the V. alginolyticus strain than those of the oyster and the penshell. Signs of the disease were similar to bacillary necrosis described in previous work. Interspecies differences in susceptibility to pathogens are discussed.

Use of moving heat conductor mesh to perform reflood calculations with RELAP4/MOD6

International Nuclear Information System (INIS)

Fischer, S.R.; Ellis, L.V.; Chen, Y.S.

1979-01-01

RELAP4 is a computer code which can be used for the transient thermal hydraulic analysis of light water reactors and related systems. RELAP4/MOD6 includes many new analytical models which were developed primarily for the analysis of the reflood phase of a PWR loss-of-coolant accident (LOCA) transient. The key feature forming the basis for the MOD6 reflood calculation is a unique moving finite differenced heat conductor. The development and application of the moving heat conductor mesh for use in reflood analysis are described

Construction of low-cost, Mod-OA wood composite wind turbine blades

Science.gov (United States)

Lark, R. F.

1983-01-01

Two sixty-foot, low-cost, wood composite blades for service on 200 kW Mod-OA wind turbines were constructed. The blades were constructed of epoxy resin-bonded Douglas fir veneers for the leading edge sections, and paper honeycombcored, birch plywood faced panels for the afterbody sections. The blades were joined to the wind turbine hub by epoxy resin-bonded steel load take-off studs embedded into the root end of the blades. The blades were installed on the 200 kW Mod-OA wind turbine facility at Kahuku, Hawaii, The blades completed nearly 8,000 hours of operation over an 18 month period at an average power of 150 kW prior to replacement with another set of wood composite blades. The blades were replaced because of a corrosion failure of the steel shank on one stud. Inspections showed that the wood composite structure remained in excellent condition.

3D effects on RWM physics in RFX-mod

International Nuclear Information System (INIS)

Baruzzo, M.; Bolzonella, T.; Guo, S.C.; Marchiori, G.; Paccagnella, R.; Soppelsa, A.; Wang, Z.R.; Liu, Y.Q.; Villone, F.

2011-01-01

In this paper insights into the behaviour of resistive wall modes (RWMs) in the RFX-mod reversed field pinch device are given, with a focus on 3D issues in the characterization of the m spectrum of the mode and on the study of multi-harmonic coupling. In the first part of the paper the interaction between multiple unstable RWMs is studied and the presence of a coupling between different poloidal components of the most unstable RWM is demonstrated, taking advantage of the flexibility of the RFX-mod control system. In the second part of the work, the dependence of the growth rates of RWMs on a complete set of plasma parameters is studied in order to create a complete and homogeneous database, which permits a careful validation of stability codes. Finally, the experimental data are compared with the code predictions which take into account the 3D structure of conductors around the plasma. The different effects that modify the simple description, where unstable modes can be identified with single Fourier harmonics, appear to be explained by a mixture of toroidicity-induced and 3D eddy current effects.

RELAP4/MOD6 analysis of forced- and gravity-feed reflood tests

International Nuclear Information System (INIS)

Chen, T.H.; Fletcher, C.D.

1980-01-01

The RELAP4/MOD6 computer code is used for the analysis of the reactor core heat transfer during the reflooding phase of a postulated loss-of-coolant accident (LOCA) in a pressurized water reactor (PWR). The code requires the user to specify input parameters for the reflood heat transfer models. Results of previous comparisons of code calculations with experimental data have indicated no single selection of input parameters is adequate for a spectrum of tests and test facilities. This paper presents the development of revised quidelines and assesses the effect of those modifications on RELAP4/MOD6 data comparisons using previously analyzed reflood experiments. The paper also presents an assessment of the revised guidelines and the original guidelines against experimental data significantly different from previously analyzed tests

Host Phenology and Leaf Effects on Susceptibility of California Bay Laurel to Phytophthora ramorum.

Science.gov (United States)

Johnston, Steven F; Cohen, Michael F; Torok, Tamas; Meentemeyer, Ross K; Rank, Nathan E

2016-01-01

Spread of the plant pathogen Phytophthora ramorum, causal agent of the forest disease sudden oak death, is driven by a few competent hosts that support spore production from foliar lesions. The relationship between traits of a principal foliar host, California bay laurel (Umbellularia californica), and susceptibility to P. ramorum infection were investigated with multiple P. ramorum isolates and leaves collected from multiple trees in leaf-droplet assays. We examined whether susceptibility varies with season, leaf age, or inoculum position. Bay laurel susceptibility was highest during spring and summer and lowest in winter. Older leaves (>1 year) were more susceptible than younger ones (8 to 11 months). Susceptibility was greater at leaf tips and edges than the middle of the leaf. Leaf surfaces wiped with 70% ethanol were more susceptible to P. ramorum infection than untreated leaf surfaces. Our results indicate that seasonal changes in susceptibility of U. californica significantly influence P. ramorum infection levels. Thus, in addition to environmental variables such as temperature and moisture, variability in host plant susceptibility contributes to disease establishment of P. ramorum.

Du teikei à l’AMAP, un modèle acculturé

Directory of Open Access Journals (Sweden)

Jean Lagane

2011-05-01

Full Text Available Cet article compare à travers deux ethnographies en France et au Japon le modèle français de l’AMAP – association de maintien de l’agriculture paysanne – au modèle dont il se réclame, le teikei, système japonais de partenariat agricole entre producteurs et consommateurs. Terrain en mutation permanente, le développement des formes de circuit court et leurs emprunts accentuent lors de la transposition la nécessité de coller le plus étroitement possible à la réalité du terrain, à son histoire sociétale, à ses traditions institutionnelles et culturelles, à ses crises, à ses dynamiques. L’analyse fait apparaître à travers les similitudes, dissemblances et adaptations de ce modèle d’emprunt, l’incidence et la complexité de la prise en compte de facteurs culturels.After two ethnological fieldworks completed in France and Japan, this article deals with the French system of Community Supported Agriculture - AMAP - and its Japanese inspiration counterpart, the Teikei system built upon local solidarity-based partnerships between farmers and members. Constantly evolving, the growing process of agriculture one-shot sale circuits and the way they are received in other cultures recalls the necessity to tune with the reality of these societies, their history, their institutional and cultural traditions as well as their crises and dynamics. The analysis emphasizes the complexity of the acculturation process related with points of convergence and discrepancy.

RELAP4/MOD-5-CEA pump coastdown experiment simulation

International Nuclear Information System (INIS)

Borges, R.C.; Freitas, R.L.

1988-07-01

Since is important the theoretical-experimental comparison to evaluate the computer codes, these paper presents the simulation with RELAP4/MOD5 Code of a loss of power energy in the pump of the ''Circuito Experimental de Agua-CEA''. From the results attained, the existing models in the Code showed to be very satisfatory quantitative and qualitative behavior of the attained experimental results. (author) [pt

TRAC-PF1 MOD1 post test calculations of the OECD LOFT Experiment LP-SB-1

International Nuclear Information System (INIS)

Allen, E.J.

1990-04-01

Analysis of the small, hot leg break, OECD LOFT Experiment LP-SB-1. using the ''best-estimate'' computer code TRAC-PF1/MOD1 is presented. Descriptions of the LOFT facility and the LP-SB-1 experiment are given and development of the TRAC-PF1/MOD1 input model is detailed. The calculations performed in achieving the steady state conditions, from which the experiment was initiated, and the specification of experimental boundary conditions are outlined. 24 refs., 66 figs., 12 tabs

Mod-5A Wind Turbine Generator Program Design Report. Volume 4: Drawings and Specifications, Book 1

Science.gov (United States)

1984-01-01

The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. Volume 4 contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the first of five books of volume four. It contains structural design criteria, generator step-up transformer specs, specs for design, fabrication and testing of the system, specs for the ground control enclosure, systems specs, slip ring specs, and control system specs.

Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

Energy Technology Data Exchange (ETDEWEB)

Lacko, Martin [Department of Otorhinolaryngology—Head and Neck Surgery, Maastricht University Medical Center, Maastricht (Netherlands); Braakhuis, Boudewijn J.M. [Department of Otolaryngology—Head and Neck Surgery, VU University Medical Center, Amsterdam (Netherlands); Sturgis, Erich M. [Department of Head and Neck Surgery and Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Boedeker, Carsten C. [Department of Otorhinolaryngology—Head and Neck Surgery, Albert-Ludwigs-University, Freiburg, Germany and Department of Otorhinolaryngology - Head and Neck Surgery, HELIOS Hanseklinikum Stralsund, Stralsund (Germany); Suárez, Carlos [Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo (Spain); Instituto Universitario de Oncología del Principado de Asturias, Oviedo (Spain); Rinaldo, Alessandra; Ferlito, Alfio [ENT Clinic, University of Udine, Udine (Italy); Takes, Robert P., E-mail: robert.takes@radboudumc.nl [Department of Otolaryngology—Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen (Netherlands)

2014-05-01

Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and its incidence is growing. Although environmental carcinogens and carcinogenic viruses are the main etiologic factors, genetic predisposition obviously plays a risk-modulating role, given that not all individuals exposed to these carcinogens experience the disease. This review highlights some aspects of genetic susceptibility to HNSCC: among others, genetic polymorphisms in biotransformation enzymes, DNA repair pathway, apoptotic pathway, human papillomavirus-related pathways, mitochondrial polymorphisms, and polymorphism related to the bilirubin-metabolized pathway. Furthermore, epigenetic variations, familial forms of HNSCC, functional assays for HNSCC risk assessment, and the implications and perspectives of research on genetic susceptibility in HNSCC are discussed.

Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

International Nuclear Information System (INIS)

Lacko, Martin; Braakhuis, Boudewijn J.M.; Sturgis, Erich M.; Boedeker, Carsten C.; Suárez, Carlos; Rinaldo, Alessandra; Ferlito, Alfio; Takes, Robert P.

2014-01-01

Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and its incidence is growing. Although environmental carcinogens and carcinogenic viruses are the main etiologic factors, genetic predisposition obviously plays a risk-modulating role, given that not all individuals exposed to these carcinogens experience the disease. This review highlights some aspects of genetic susceptibility to HNSCC: among others, genetic polymorphisms in biotransformation enzymes, DNA repair pathway, apoptotic pathway, human papillomavirus-related pathways, mitochondrial polymorphisms, and polymorphism related to the bilirubin-metabolized pathway. Furthermore, epigenetic variations, familial forms of HNSCC, functional assays for HNSCC risk assessment, and the implications and perspectives of research on genetic susceptibility in HNSCC are discussed

Mechanical behaviour of SFR materials: proposition of fatigue weld joint coefficient for MOD9CR-1MO

International Nuclear Information System (INIS)

Ancelet, O.; Matheron, Ph.

2012-01-01

Mod 9Cr-1Mo steel (T91) is a candidate material for steam generator of SFR (Sodium Fast Reactors). In order to validate this choice, it is necessary, firstly to verify that it is able to withstand the planned environmental and operating conditions, and secondly to check if it is covered by the existing design codes, concerning its procurement, fabrication, welding, examination methods and mechanical design rules. A large R and D program on mod9Cr-1Mo steel has been undertaken at CEA in order to characterize the behavior of this material and of its welded junctions. In this program, the role of the Laboratory for structural Integrity and Standards (LISN) is to develop high temperature defect assessment procedures under fatigue and creep loadings. In this frame, complementary studies are conducted in order to validate the existing methods (developed for the fast reactors) and to get new experimental data on Mod9Cr-1Mo steel. In particular, some new experiments are conducted on specimen with a weld joint and compared with classical experiments on base metal specimen. These results associated with finite element modeling allow to propose a weld joint coefficient at 550 degrees C for the Mod9Cr1Mo steel. (authors)

Evaluation of the RELAP4/MOD6 thermal-hydraulic code

International Nuclear Information System (INIS)

Haigh, W.S.; Margolis, S.G.; Rice, R.E.

1978-01-01

The NRC RELAP4/MOD6 computer code was recently released to the public for use in thermal-hydraulic analysis. This code has a unique new capability permitting analysis of both the blowdown and reflood portions of a postulated pressurized water reactor (PWR) loss-of-coolant accident (LOCA). A principal code evaluation objective is to assess the accuracy of the code for computing LOCA behavior over a wide range of system sizes and scaling concepts. The scales of interest include all LOCA experiments and will ultimately encompass full-sized PWR systems for which no experiments or data are available. Quantitative assessment of the accuracy of the code when it is applied to large PWR systems is still in the future. With RELAP4/MOD6, however, a technique has been demonstrated for using results derived from small-scale blowdown and reflood experiments to predict the accuracy of calculations for similar experiments of significantly different scale or component size. This demonstration is considered a first step in establishing confidence levels for the accuracy of calculations of a postulated LOCA

Measurement of local critical currents in TFA-MOD processed coated conductors by use of scanning Hall-probe microscopy

International Nuclear Information System (INIS)

Shiohara, K.; Higashikawa, K.; Kawaguchi, T.; Inoue, M.; Kiss, T.; Yoshizumi, M.; Izumi, T.

2011-01-01

We have investigated 2-dimensional distribution of critical current density. We have measured TFA-MOD processed YBCO coated conductor. We used scanning Hall-probe microscopy. These provided information is useful for fabrication process of coated conductor. We have carried out 2-dimensional (2D) measurement of local critical current in a Trifluoroacetates-Metal Organic Deposition (TFA-MOD) processed YBCO coated conductor using scanning Hall-probe microscopy. Recently, remarkable R and D accomplishments on the fabrication processes of coated conductors have been conducted extensively and reported. The TFA-MOD process has been expected as an attractive process to produce coated conductors with high performance at a low production cost due to a simple process using non-vacuum equipments. On the other hand, enhancement of critical currents and homogenization of the critical current distribution in the coated conductors are definitely very important for practical applications. According to our measurements, we can detect positions and spatial distribution of defects in the conductor. This kind of information will be very helpful for the improvement of the TFA-MOD process and for the design of the conductor intended for practical electric power device applications.

TRAC-PF1/MOD3 calculations of Savannah River Laboratory Rig FA single-annulus heated experiments

International Nuclear Information System (INIS)

Fischer, S.R.; McDaniel, C.K.

1992-01-01

This paper presents the results of TRAC-PF1/MOD3 benchmarks of the Rig FA experiments performed at the Savannah River Laboratory to simulate prototypic reactor fuel assembly behavior over a range of fluid conditions typical of the emergency cooling system (ECS) phase of a loss-of-coolant accident (LOCA). The primary purpose of this work was to use the SRL Rig FA tests to qualify the TRAC-PF1/MOD3 computer code and models for computing Mark-22 fuel assembly LOCA/ECS power limits. This qualification effort was part of a larger effort undertaken by the Los Alamos National Laboratory for the US Department of Energy to independently confirm power limits for the Savannah River Site K Reactor. The results of this benchmark effort as discussed in this paper demonstrate that TRAC/PF1/MOD3 coupled with proper modeling is capable of simulating thermal-hydraulic phenomena typical of that encountered in Mark-22 fuel assembly during LOCA/ECS conditions

RELAP5/MOD2 code modifications to obtain better predictions for the once-through steam generator

International Nuclear Information System (INIS)

Blanchat, T.; Hassan, Y.

1989-01-01

The steam generator is a major component in pressurized water reactors. Predicting the response of a steam generator during both steady-state and transient conditions is essential in studying the thermal-hydraulic behavior of a nuclear reactor coolant system. Therefore, many analytical and experimental efforts have been performed to investigate the thermal-hydraulic behavior of the steam generators during operational and accident transients. The objective of this study is to predict the behavior of the secondary side of the once-through steam generator (OTSG) using the RELAP5/MOD2 computer code. Steady-state conditions were predicted with the current version of the RELAP5/MOD2 code and compared with experimental plant data. The code predictions consistently underpredict the degree of superheat. A new interface friction model has been implemented in a modified version of RELAP5/MOD2. This modification, along with changes to the flow regime transition criteria and the heat transfer correlations, correctly predicts the degree of superheat and matches plant data

PREFACE: Modern Technologies in Industrial Engineering (ModTech2015)

Science.gov (United States)

Oanta, E.; Comaneci, R.; Carausu, C.; Placzek, M.; Cohal, V.; Topala, P.; Nedelcu, D.

2015-11-01

The dominant feature of the current stage of society development is the update, refinement and innovation of the technological processes and products whose ultimate goal is to satisfy the market requirements. New and modern technologies should be considered in terms of their applicability in industry while the materials can lead to an increase in the quality of the end products. Replacing the existing technologies with innovative and eco-efficient technologies can contribute to an added value increase in the production of new materials. Materials are one of the most dynamic and prospective fields, with applications in all other fields. The development of new advanced materials and technologies shall contribute to the procurement of a wide range of reliable products, with competitive prices and worldwide performance, high sensitivity and functionality, user-friendly and reduced energy consumption, for different industrial applications. Research in the field of advanced/intelligent materials supposes a fundamental, experimental, laboratory and technological research and its approach has to be linked to the application. This involves, even for the niche fields, complex projects which result in scientific issues in top journals, patents and functional models. The third edition of ModTech International Conference was held in Mamaia, Romania, between June 17-20, with the Professional Association in Modern Manufacturing Technologies, ModTech, as main organizer, and the Constanta Maritime University, Constanta, Romania, Silesian University of Technology, Gliwice, Poland, the Technical University of Chisinau, Republic of Moldova and the Donetsk National Technical University, Donetsk, Ukraine as co-organizers. The ModTech2015 International Conference brought together representatives of technology and materials manufacturers, various universities, professional associations and research institutes that exchanged the latest knowledge on the conference topics. This edition was

Mission Operations Directorate - Success Legacy of the Space Shuttle Program (Overview of the Evolution and Success Stories from MOD During the Space Shuttle program)

Science.gov (United States)

Azbell, Jim A.

2011-01-01

In support of the Space Shuttle Program, as well as NASA's other human space flight programs, the Mission Operations Directorate (MOD) at the Johnson Space Center has become the world leader in human spaceflight operations. From the earliest programs - Mercury, Gemini, Apollo - through Skylab, Shuttle, ISS, and our Exploration initiatives, MOD and its predecessors have pioneered ops concepts and emphasized a history of mission leadership which has added value, maximized mission success, and built on continual improvement of the capabilities to become more efficient and effective. This paper provides specific examples that illustrate how MOD's focus on building and contributing value with diverse teams has been key to their successes both with the US space industry and the broader international community. This paper will discuss specific examples for the Plan, Train, Fly, and Facilities aspects within MOD. This paper also provides a discussion of the joint civil servant/contractor environment and the relative badge-less society within MOD. Several Shuttle mission related examples have also been included that encompass all of the aforementioned MOD elements and attributes, and are used to show significant MOD successes within the Shuttle Program. These examples include the STS-49 Intelsat recovery and repair, the (post-Columbia accident) TPS inspection process and the associated R-Bar Pitch Maneuver for ISS missions, and the STS-400 rescue mission preparation efforts for the Hubble Space Telescope repair mission. Since their beginning, MOD has consistently demonstrated their ability to evolve and respond to an ever changing environment, effectively prepare for the expected and successfully respond to the unexpected, and develop leaders, expertise, and a culture that has led to mission and Program success.

Assessment of RELAP5/MOD3.2 with condensation experiment in the presence of noncondensables in a vertical tube

Energy Technology Data Exchange (ETDEWEB)

Park, Hyun Sik; No, Hee Cheon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1999-12-31

The standard RELAP5/MOD3.2 code were assessed with the condensation experiment in the presence of noncondensable gas in a vertical tube of PCCS of CP-1300. There are two wall film condensation models, the default model and the alternative model, in RELAP5/MOD3.2. The experimental apparatus was modeled with the two models, and simulations were performed for several sub-tests to be compared with the experimental results. In overall sense the simulation results showed that the default model of RELAP5/MOD3.2 under-predicts the heat transfer coefficients, while the alternative model over-predicts them throughout the condensing tube. 10 refs., 6 figs. (Author)

Assessment of RELAP5/MOD3.2 with condensation experiment in the presence of noncondensables in a vertical tube

Energy Technology Data Exchange (ETDEWEB)

Park, Hyun Sik; No, Hee Cheon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1998-12-31

The standard RELAP5/MOD3.2 code were assessed with the condensation experiment in the presence of noncondensable gas in a vertical tube of PCCS of CP-1300. There are two wall film condensation models, the default model and the alternative model, in RELAP5/MOD3.2. The experimental apparatus was modeled with the two models, and simulations were performed for several sub-tests to be compared with the experimental results. In overall sense the simulation results showed that the default model of RELAP5/MOD3.2 under-predicts the heat transfer coefficients, while the alternative model over-predicts them throughout the condensing tube. 10 refs., 6 figs. (Author)

Evaluation of the applicability of cladding deformation model in RELAP5/MOD3.2 code for VVER-1000 fuel

International Nuclear Information System (INIS)

Vorob'ev, Yu.; Zhabin, O.

2015-01-01

Applicability of cladding deformation model in RELAP5/MOD3.2 code is analyzed for VVER-1000 fuel cladding from Zr+1%Nb alloy. Experimental data and calculation model of fuel assembly channel of the core are used for this purpose. The model applicability is tested for the cladding temperature range from 600 to 1200 deg C and pressure range from 1 to 12 MPa. Evaluation results demonstrate limited applicability of built-in RELAP5/MOD3.2 cladding deformation model to the estimation of Zr+1%Nb cladding rupture conditions. The limitations found shall be considered in application of RELAP5/MOD3.2 cladding deformation model in the design-basis accident analysis of VVER reactors

L’esprit du droit : modèle russe contre modèle français Sense of law : Russian model versus French model

Directory of Open Access Journals (Sweden)

Chantal Kourilsky-Augeven

2009-06-01

Full Text Available Un stéréotype récurrent dans la littérature russe distingue entre un « esprit » ou « sens du droit » qui serait propre à la culture française et un « sens de la justice » qui serait propre à la culture russe. Cette distinction s’appliquerait au premier chef à une religion catholique qualifiée de juridique en ce qu’elle serait comptable des péchés et une religion orthodoxe davantage fondée sur l’amour. Mais le modèle traditionnel russe pris en compte par la littérature, l’histoire et l’anthropologie ne saurait être statique. Deux enquêtes menées auprès de populations d’adolescents et d’adultes en 1993 et 2000 montrent comment le modèle russe fondé sur la justice et la morale se juridicise et en arrive à rejoindre le modèle français sur plusieurs points.A recurring stereotype in Russian literature opposes a « sense of law » inherent to French culture to a « sense of justice » inherent to Russian culture.This distinction is first and foremost applied to a catholic religion qualified as legalistic due to a strict accounting of sins and an orthodox religion essentially based on love. But the traditional Russian model described by literature, history and anthropology is anything but static. Two research projects carried out among an adolescent and adult population sample in 1993 and 2000 show how a Russian model based on justice and morals is being judiciarized and is increasingly moving towards the French model on several accounts.

Disruption Neutral Point Experiment on Alcator C-Mod

Science.gov (United States)

Granetz, R. S.; Nakamura, Y.

2000-10-01

Disruptions of single-null elongated plasmas generally result in loss of vertical position control, leading to a current quench occurring at the top or bottom of the machine, with all the attendant problems of halo and eddy currents flowing in divertor structures. On JT-60U, it has been found that if the plasma is operated with its magnetic axis at a particular height, called the neutral point, the initial vertical drift after a thermal quench is significantly slower than usual, and sometimes can even be arrested, thereby avoiding a current quench in the divertor region entirely. In an ongoing collaboration between MIT and JAERI, the neutral point concept is being tested in Alcator C-Mod, which has a significantly higher plasma elongation than JT-60U (1.65 vs 1.3). Calculations using TSC predict a neutral point at z~=+1 cm above the midplane (a=22 cm). The existence of a neutral point has now been experimentally confirmed, albeit at a height of z=+2.7 cm. The plasma has remained vertically stable for up to 9 ms after the disruption thermal quench, which in principle, is long enough for the PF control system to respond, if programmed appropriately. In addition, the physics of the neutral point stability on C-Mod appears to be somewhat different than that on JT-60U.

Susceptibility of pathogenic and nonpathogenic Naegleria ssp

International Nuclear Information System (INIS)

Whiteman, L.Y.

1988-01-01

The susceptibility of four species of Naegleria amoebae to complement-mediated lysis was determined. The amoebicidal activity of normal human serum (NHS) and normal guinea pig serum (NGPS) for Naegleria amoebae was measured by an in vitro cytotoxicity assay. Release of radioactivity from amoebae labeled with 3 H-uridine and visual observation with a compound microscope were used as indices of lysis. Susceptibility or resistance to complement-mediated lysis in vitro correlated with the in vivo pathogenic potential. Nonpathogenic Naegleria amoebae were lysed at a faster rate and at higher cell concentrations than were pathogenic amoebae. Electrophoretic analysis of NHS incubated with pathogenic or nonpathogenic Naegleria spp. demonstrated that amoebae activate the complement cascade resulting in the production of C3 and C5 complement cleavage products. Treatment with papain or trypsin for 1 h, but not with sialidase, increase the susceptibility of highly pathogenic, mouse-passaged N. fowleri to lysis. Treatment with actinomycin D, cycloheximide or various protease inhibitors for 4 h did not increase susceptibility to lysis. Neither a repair process involving de novo protein synthesis nor a complement-inactivating protease appear to account for the increase resistance of N. fowleri amoebae to complement-mediated lysis. A binding study with 125 I radiolabeled C9 indicated that the terminal complement component does not remain stably bound to the membrane of pathogenic amoebae

Implementation of JAERI's reflood model into TRAC-PF1/MOD1 code

International Nuclear Information System (INIS)

Akimoto, Hajime; Ohnuki, Akira; Murao, Yoshio

1993-02-01

Selected physical models of REFLA code, that is a reflood analysis code developed at JAERI, were implemented into the TRAC-PF1/MOD1 code in order to improve the predictive capability of the TRAC-PF1/MOD1 code for the core thermal hydraulic behaviors during the reflood phase in a PWR LOCA. Through comparisons of physical models between both codes, (1) Murao-Iguchi void fraction correlation, (2) the drag coefficient correlation acting to drops, (3) the correlation for wall heat transfer coefficient in the film boiling regime, (4) the quench velocity correlation and (5) heat transfer correlations for the dispersed flow regime were selected from the REFLA code to be implemented into the TRAC-PF1/MOD1 code. A method for the transformation of the void fraction correlation to the equivalent interfacial friction model was developed and the effect of the transformation method on the stability of the solution was discussed. Through assessment calculation using data from CCTF (Cylindrical Core Test Facility) flat power test, it was confirmed that the predictive capability of the TRAC code for the core thermal hydraulic behaviors during the reflood can be improved by the implementation of selected physical models of the REFLA code. Several user guidelines for the modified TRAC code were proposed based on the sensitivity studies on fluid cell number in the hydraulic calculation and on node number and effect of axial heat conduction in the heat conduction calculation of fuel rod. (author)

Radon transport modelling: User's guide to RnMod3d

Energy Technology Data Exchange (ETDEWEB)

Andersen, C.E

2000-08-01

RnMod3d is a numerical computer model of soil-gas and radon transport in porous media. It can be used, for example, to study radon entry from soil into houses in response to indoor-outdoor pressure differences or changes in atmospheric pressure. It can also be used for flux calculations of radon from the soil surface or to model radon exhalation from building materials such as concrete. The finite-volume model is a technical research tool, and it cannot be used meaningfully without good understanding of the involved physical equations. Some understanding of numerical mathematics and the programming language Pascal is also required. Originally, the code was developed for internal use at Risoe only. With this guide, however, it should be possible for others to use the model. Three-dimensional steady-state or transient problems with Darcy flow of soil gas and combined generation, radioactive decay, diffusion and advection of radon can be solved. Moisture is included in the model, and partitioning of radon between air, water and soil grains (adsorption) is taken into account. Most parameters can change in time and space, and transport parameters (diffusivity and permeability) may be anisotropic. This guide includes benchmark tests based on simple problems with known solutions. RnMod3d has also been part of an international model intercomparison exercise based on more complicated problems without known solutions. All tests show that RnMod3d gives results of good quality. (au)

The design of a second harmonic tangential array interferometer for C-Mod

International Nuclear Information System (INIS)

Bretz, N.; Jobes, F.; Irby, J.

1997-01-01

A design for a tangential array interferometer for C-Mod operating at 1.06 and 0.53 μm is presented. This is a special type of two color interferometer in which a Nd:YAG laser is frequency doubled in a nonlinear crystal. Because the doubling efficiency is imperfect, two frequencies propagate collinearly through the plasma after which the 1.06 μm ray is doubled again mixing in the optical domain with the undoubled ray. The resulting interference is insensitive to path length but is affected by plasma dispersion in the usual way. A typical central fringe shift in C-Mod is expected to be 0.1 endash 1.0, but the absolute and relative accuracy in n e l measurements can be as high as in a conventional interferometer. This design uses a repetitively pulsed laser which is converted to a fan beam crossing the horizontal midplane. The chordal array is defined by internal retroreflectors on the C-Mod midplane which return the beam to the second doubler and a detector array. This interferometer design has beam diameters of a few millimeters and element spacings of a few centimeters, uses a repetitively pulsed, TEM 00 Nd:YAG laser, fiber optic beam transport, commercial components, and a compact optical design which minimizes port space requirements. An optical system design is presented which is based on the performance of a tabletop prototype at Princeton Plasma Physics Laboratory. copyright 1997 American Institute of Physics

Edge plasma physics modifications due to magnetic ripple in RFX-mod

International Nuclear Information System (INIS)

Scarin, P.; Agostini, M.; Carraro, L.; Cavazzana, R.; Ciaccio, G.; De Masi, G.; Spizzo, G.; Spolaore, M.; Vianello, N.

2015-01-01

The edge of the RFX-mod (R = 2 m, a = 0.46 m) Reversed Field Pinch is characterized by weak magnetic chaos affecting ion and electron diffusion. Edge particle transport is strongly influenced by a toroidal asymmetry caused by magnetic islands. An ambipolar radial electric field ensures local neutrality and possesses the same symmetry as the parent magnetic ripple: the result is the modulation of the perpendicular flow, with a slowing-down at the island X-point. In this paper we present a complete statistical analysis, over a large database of RFX-mod discharges, of the edge properties as they are modified by the magnetic topology: the plasma wall footprint follows the helical shape of the dominant central mode (m/n = 1/7), with an increase of H α emission and electron density corresponding to the O-point of the inner magnetic island. Edge turbulence is modified by the magnetic topology, being generated in the O-point region and damped near the X-point

The Role of Plasma Rotation in C-Mod Internal Transport Barriers

Science.gov (United States)

Fiore, C. L.; Ernst, D. R.; Rice, J. E.; Podpaly, Y.; Reinke, M. L.; Greenwald, M. J.; Hughes, J. W.; Ma, Y.; Bespamyatnov, I. O.; Rowan, W. L.

2010-11-01

ITBs in Alcator C-Mod featuring highly peaked density and pressure profiles are induced by injecting ICRF power with the second harmonic of the resonant frequency for minority hydrogen off-axis at the plasma half radius. These ITBs are formed in the absence of particle or momentum injection, and with monotonic q profiles with qmin ITB forms, this rotation decreases in the center of the plasma and forms a well, and often reverses direction in the core. This indicates that there is a strong EXB shearing rate in the region where the foot in the ITB density profile is observed. Preliminary gyrokinetic analyses indicate that this shearing rate is comparable to the ion temperature gradient mode (ITG) growth rate at this location and may be responsible for stabilizing the turbulence. Gyrokinetic analyses of recent experimental data obtained from a complete scan of the ICRF resonance position across the entire C-Mod plasma will be presented.

Assessment of RELAP5/MOD2 against a natural circulation experiment in Nuclear Power Plant Borssele

International Nuclear Information System (INIS)

Winters, L.

1993-07-01

As part of the ICAP (International Code Assessment and Applications Program) agreement between ECN (Netherlands Energy Research Foundation) and USNRC, ECN has performed a number of assessment calculations for the thermohydraulic system analysis code RELAP5/MOD2/36.05. This document describes the assessment of this computer program versus a natural circulation experiment as conducted at the Borssele Nuclear Power Plant. The results of this comparison show that the code RELAP5/MOD2 predicts well the natural circulation behaviour of Nuclear Power Plant Borssele

Blowdown heat transfer surface in RELAP4/MOD6 and data comparisons

International Nuclear Information System (INIS)

Nelson, R.A.; Sullivan, L.H.

1978-01-01

RELAP4 is a thermal hydraulic analysis tool written to analyze transients in light water reactors (LWR). To date, most of the applications for RELAP4 have been to analyze postulated LOCA transients in LWR and the response of experimental systems to loss-of-coolant experiments. An important part of these analyses is the prediction of the fuel rod or heater surface temperature which involves the calculation of surface heat transfer coefficients. The paper describes the outcome of a significant blowdown heat transfer development effort which is incorporated in RELAP4/MOD6 (the current version of the code available to the United States public from the Argonne Code Center). The primary emphasis in the MOD6 development was on a PWR reflood capability. The best-estimate blowdown heat transfer correlation and logic were added to provide improved blowdown predictive capability

RELAP5/MOD2 Overview and Developmental. Assessment Results from TMl-1 Plant Transient Analysis

International Nuclear Information System (INIS)

Lin, J. C.; Tsai, C. C.; Ransom, V. H.; Johnsen, G. W.

2013-01-01

RELAP5/MOD2 is a new version of the RELAP5 thermal-hydraulic computer code containing improved modeling features that provide a generic capability for pressurized water reactor transient simulation. The objective of this paper is to provide code users with an overview of the code and to report developmental assessment results obtained from a Three Mile Island Unit One plant transient analysis. The assessment shows that the injection of highly sub-cooled water into a high-pressure primary coolant system does not cause unphysical results or pose a problem for RELAP5/MOD2. (author)

Assessment of ICRF Antenna Performance in Alcator C-Mod

International Nuclear Information System (INIS)

Schilling, G.; Wukitch, S.J.; Lin, Y.; Basse, N.; Bonoli, P.T.; Edlund, E.; Lin, L.; Parisot, A.; Porkolab, M.

2004-01-01

The Alcator C-Mod has presented a challenge to install high-power ICRF antennas in a tight space. Modifications have been made to the antenna plasma-facing surfaces and the internal current-carrying structure in order to overcome performance limitations. At the present time, the antennas have exceeded 5 MW into plasma with heating phasing, up to 2.7 MW with current-drive phasing, with good efficiency and no deleterious effects

Fluorometric assay for phenotypic differentiation of drug-resistant HIV mutants

Science.gov (United States)

Zhu, Qinchang; Yu, Zhiqiang; Kabashima, Tsutomu; Yin, Sheng; Dragusha, Shpend; El-Mahdy, Ahmed F. M.; Ejupi, Valon; Shibata, Takayuki; Kai, Masaaki

2015-01-01

Convenient drug-resistance testing of viral mutants is indispensable to effective treatment of viral infection. We developed a novel fluorometric assay for phenotypic differentiation of drug-resistant mutants of human immunodeficiency virus-I protease (HIV-PR) which uses enzymatic and peptide-specific fluorescence (FL) reactions and high-performance liquid chromatography (HPLC) of three HIV-PR substrates. This assay protocol enables use of non-purified enzyme sources and multiple substrates for the enzymatic reaction. In this study, susceptibility of HIV mutations to drugs was evaluated by selective formation of three FL products after the enzymatic HIV-PR reaction. This proof-of-concept study indicates that the present HPLC-FL method could be an alternative to current phenotypic assays for the evaluation of HIV drug resistance. PMID:25988960

Vector models in RETRAN-02 MOD 2

International Nuclear Information System (INIS)

Kinnersly, S.R.

1985-06-01

The vector momentum model in RETRAN-02 allows momentum flux to be modelled in two dimensions. Vector models in RETRAN-2 are described, including both the actual implementation in the code and the specification given in the code manual. The vector momentum model is described in detail. Other models which use vector quantities include models for volume average flow, volume average slip velocity, volume average phase velocities and fill junction flows. Both code implementations and code manual descriptions are described and inconsistencies noted. The differences between the standard RETRA-02 Mod 2 version and the Winfrith version RETN2204 are noted. (U.K.)

Experiment data report for Semiscale Mod-1 Test S-28-1 (steam generator tube rupture test series)

International Nuclear Information System (INIS)

Collins, B.L.; Coppin, C.E.; Sackett, K.E.

1977-10-01

Recorded test data are presented for Test S-28-1 of the Semiscale Mod-1 steam generator tube rupture test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-28-1 was conducted from initial conditions of 15 767 kPa and 557 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. Sixty steam generator tube ruptures were simulated by a controlled injection from a heated accumulator into the intact loop hot leg

Calculation of design load for the MOD-5A 7.3 mW wind turbine system

Science.gov (United States)

Mirandy, L.; Strain, J. C.

1995-01-01

Design loads are presented for the General Electric MOD-SA wind turbine. The MOD-SA system consists of a 400 ft. diameter, upwind, two-bladed, teetered rotor connected to a 7.3 mW variable-speed generator. Fatigue loads are specified in the form of histograms for the 30 year life of the machine, while limit (or maximum) loads have been derived from transient dynamic analysis at critical operating conditions. Loads prediction was accomplished using state of the art aeroelastic analyses developed at General Electric. Features of the primary predictive tool - the Transient Rotor Analysis Code (TRAC) are described in the paper. Key to the load predictions are the following wind models: (1) yearly mean wind distribution; (2) mean wind variations during operation; (3) number of start/shutdown cycles; (4) spatially large gusts; and (5) spatially small gusts (local turbulence). The methods used to develop statistical distributions from load calculations represent an extension of procedures used in past wind programs and are believed to be a significant contribution to Wind Turbine Generator analysis. Test/theory correlations are presented to demonstrate code load predictive capability and to support the wind models used in the analysis. In addition MOD-5A loads are compared with those of existing machines. The MOD-5A design was performed by the General Electric Company, Advanced Energy Program Department, under Contract DEN3-153 with NASA Lewis Research Center and sponsored by the Department of Energy.

Simulation de l'habitat physique du barbeau fluviatile (Barbus barbus, L. 1758 : choix des modèles biologiques et sensibilité de la réponse

Directory of Open Access Journals (Sweden)

POUILLY M.

1994-07-01

Full Text Available Des courbes monovariées et des modèles multivariés de préférence d'habitat du barbeau, Barbus barbus, ont été établis à partir de données récoltées sur 3 cours d'eau. Dans les deux cas (monovarié et multivarié, trois modèles locaux, correspondant aux données d'une rivière, et un modèle général, regroupant l'ensemble des données, ont été établis. La qualité de la prédiction et la sensibilité de la réponse lors de la simulation des capacités d'accueil d'un cours d'eau révèlent : 1 que les modèles multivariés ont une valeur prédictive plus forte que les courbes de préférence, 2 que les modèles construits à partir de jeux de données locaux sont plus performants que les modèles généraux, et 3 que la perte de précision est moindre dans le cas du modèle général multivarié.

Web based electronic logbook and experiment run database viewer for Alcator C-Mod

International Nuclear Information System (INIS)

Fredian, T.W.; Stillerman, J.A.

2006-01-01

Since 1991, the scientists and engineers at the Alcator C-Mod experiment at MIT have been recording text entries about the experiments being performed in an electronic logbook. In addition, separate documents such as run plans, run summaries and experimental proposals have been created and stored in a variety of formats in computer files. This information has now been organized and made available via any modern web browser. The new web based interface permits the user to browse through all the logbook entries, run information and even view some key data traces of the experiment. Since this information is being catalogued by Internet search engines, these tools can also be used to quickly locate information. The web based logbook and run information interface provides some additional capabilities. Once logged into the web site, users can add, delete or modify logbook entries directly from their browser. The logbook window on their browser also provides dynamic updating when any new logbook entries are made. There is also live C-Mod operation status information with optional audio announcements available. The user can receive the same state change announcements such as 'entering init' or 'entering pulse' as they would if they were sitting in the C-Mod control room. This paper will describe the functionality of the web based logbook and how it was implemented

Models for the Behavior of Offshore Structure Foundations. Part One: Methodologies and Rheological Models for Soils Modèles pour le comportement des fondations d'ouvrages types marins. Première partie : Méthodologies et modèles rhéologiques de sols

Directory of Open Access Journals (Sweden)

Meimon Y.

2006-11-01

structure. Prospects opened up by the research are discussed. La conception des fondations de grands ouvrages est une tâche complexe qui requiert à la fois l'expérience de l'expert et l'utilisation de modèles numériques adéquats pour assurer la sécurité et optimiser les coûts de dimensionnement. En fait, prévoir le comportement d'une fondation nécessite de bien évaluer les effets combinés de la technique de mise en place, de la variabilité spatiale des propriétés mécaniques, de l'incertitude sur les chargements et des techniques de modélisation du comportement mécanique des géomatériaux. Ceci est particulièrement vrai pour les plates-formes marines, qu'elles soient destinées à l'exploration ou à la production du pétrole, dans la mesure où les chargements non-monotones dus à l'environnement marin, souvent très sévère, peuvent avoir des effets très néfastes sur le comportement de ces structures. On présente, en deux parties, la synthèse d'une dizaine d'années d'activités de recherche, menées par une équipe de l'Institut Français du Pétrole (IFP, en collaboration avec plusieurs équipes universitaires et des centres techniques et industriels, pour la mise au point de méthodologies et d'outils adaptés au calcul du comportement des fondations d'ouvrages types marins durant toute la durée de vie de la plate-forme. Cet article concerne la première partie qui est dévolue à l'exposé des démarches développées et à la modélisation de l'état local des géomatériaux par des modèles rhéologiques. Démarches de modélisation du comportement des fondations d'ouvrages marins : On analyse d'abord la spécificité des fondations de plates-formes marines en insistant sur les différences avec les ouvrages à terre : dimension inusitée, chargement aléatoire par les éléments marins. On peut alors dégager plusieurs types de fondation (fig. 2. 1 et 2. 2 et les classes de problèmes qu'il est important d'étudier, qui recouvrent aussi

The implementation of the CDC version of RELAP5/MOD1/019 on an IBM compatible computer system (AMDAHL 470/V8)

International Nuclear Information System (INIS)

Kolar, W.; Brewka, W.

1984-01-01

RELAP5/MOD1 is an advanced one-dimensional best estimate system code, which is used for safety analysis studies of nuclear pressurized water reactor systems and related integral and separate effect test facilities. The program predicts the system response for large break, small break LOCA and special transients. To a large extent RELAP5/MOD1 is written in Fortran, only a small part of the program is coded in CDC assembler. RELAP5/MOD1 was developed on the CDC CYBER 176 at INEL*. The code development team made use of CDC system programs like the CDC UPDATE facility and incorporated in the program special purpose software packages. The report describes the problems which have been encountered when implementing the CDC version of RELAP5/MOD1 on an IBM compatible computer systems (AMDAHL 470/V8)

Mod-1 wind turbine generator analysis and design report, volume 1

Science.gov (United States)

1979-01-01

The activities leading to the completion of detail design of the MOD-1 wind turbine generator are described. Emphasis is placed on the description of the design as it finally evolved. However, the steps through which the design progressed are also traced in order to understand the major design decisions.

Effect of reflection on Hα emissions in Alcator C-MOD

International Nuclear Information System (INIS)

Karney, C.F.; Stotler, D.P.; Skinner, C.H.; Terry, J.L.; Pappas, D.A.

1999-01-01

In order to explain anomalous intensity ratios which have been observed in Alcator C-MOD, the H α emissions in that experiment have been modeled with the DEGAS 2 code including the effects of wall reflection. By assuming that the first wall has different reflection coefficients for the two polarizations, we have qualitatively reproduced the observed anomaly. copyright 1999 American Institute of Physics

Antimicrobial susceptibility patterns of Ureaplasma species and Mycoplasma hominis in pregnant women.

Science.gov (United States)

Redelinghuys, Mathys J; Ehlers, Marthie M; Dreyer, Andries W; Lombaard, Hennie A; Kock, Marleen M

2014-03-28

Genital mycoplasmas colonise up to 80% of sexually mature women and may invade the amniotic cavity during pregnancy and cause complications. Tetracyclines and fluoroquinolones are contraindicated in pregnancy and erythromycin is often used to treat patients. However, increasing resistance to common antimicrobial agents is widely reported. The purpose of this study was to investigate antimicrobial susceptibility patterns of genital mycoplasmas in pregnant women. Self-collected vaginal swabs were obtained from 96 pregnant women attending an antenatal clinic in Gauteng, South Africa. Specimens were screened with the Mycofast Revolution assay for the presence of Ureaplasma species and Mycoplasma hominis. The antimicrobial susceptibility to levofloxacin, moxifloxacin, erythromycin, clindamycin and tetracycline were determined at various breakpoints. A multiplex polymerase chain reaction assay was used to speciate Ureaplasma positive specimens as either U. parvum or U. urealyticum. Seventy-six percent (73/96) of specimens contained Ureaplasma spp., while 39.7% (29/73) of Ureaplasma positive specimens were also positive for M. hominis. Susceptibilities of Ureaplasma spp. to levofloxacin and moxifloxacin were 59% (26/44) and 98% (43/44) respectively. Mixed isolates (Ureaplasma species and M. hominis) were highly resistant to erythromycin and tetracycline (both 97% resistance). Resistance of Ureaplasma spp. to erythromycin was 80% (35/44) and tetracycline resistance was detected in 73% (32/44) of Ureaplasma spp. Speciation indicated that U. parvum was the predominant Ureaplasma spp. conferring antimicrobial resistance. Treatment options for genital mycoplasma infections are becoming limited. More elaborative studies are needed to elucidate the diverse antimicrobial susceptibility patterns found in this study when compared to similar studies. To prevent complications in pregnant women, the foetus and the neonate, routine screening for the presence of genital mycoplasmas is

Plasma performance and scaling laws in the RFX-mod reversed-field pinch experiment

International Nuclear Information System (INIS)

Innocente, P.; Alfier, A.; Canton, A.; Pasqualotto, R.

2009-01-01

The large range of plasma currents (I p = 0.2-1.6 MA) and feedback-controlled magnetic boundary conditions of the RFX-mod experiment make it well suited to performing scaling studies. The assessment of such scaling, in particular those on temperature and energy confinement, is crucial both for improving the operating reversed-field pinch (RFP) devices and for validating the RFP configuration as a candidate for the future fusion reactors. For such a purpose scaling laws for magnetic fluctuations, temperature and energy confinement have been evaluated in stationary operation. RFX-mod scaling laws have been compared with those obtained from other RFP devices and numerical simulations. The role of the magnetic boundary has been analysed, comparing discharges performed with different active control schemes of the edge radial magnetic field.

Development of wide area reaction system for Reel-to-Reel TFA-MOD process

International Nuclear Information System (INIS)

Nomoto, Sukeharu; Aoki, Yuji; Teranishi, Ryo; Sato, Akihiro; Izumi, Teruo; Shiohara, Yuh

2006-01-01

The previously developed numerical simulation method for the TFA-MOD process, which calculated the YBCO growth kinetics, gas element diffusion and gas flow, was applied to study the suitable gas flow mode for a multi-turning Reel-to-Reel tape conveyance system of a long YBCO coated conductors. The high YBCO production rate with uniform J c distribution among tape lines is desired in the system. It was found by the numerical simulation for the vertical gas flow onto the tape surface to realize the above demands even in a wider reaction area. We developed a new wide area reaction tube for the Reel-to-Reel TFA-MOD process according to the numerically designed gas flow configuration. The demand for the new tube was confirmed to be satisfied by experiments

Vectorization of LWR transient analysis code RELAP5/MOD1 and its effect

International Nuclear Information System (INIS)

Ishiguro, Misako; Harada, Hiroo; Shinozawa, Naohisa; Naraoka, Ken-itsu

1985-03-01

The RELAP5/MOD1 is a large thermal-hydraulic code to analyze LWR LOCA and non-LOCA transients. The code originally was designed for use on a CDC Cyber-176. This report documents vectorization of the RELAP5/MOD1 code conducted for the purpose of efficient use of VP-100 (peak speed 250 MFLOPS, clock period 7.5 ns) at the JAERI. The code was vectorized using the junction and volume level parallelisms in the hydrodynamic calculations, and the heat-structure and heat-mesh level in the heat conduction calculations. The vectorized version runs as much as 2.4 to 2.8 times faster than the original scalar version, while the speedup ratio is dependent on the number of spactial cells included in the problem. (author)

L'utilisation d'un modèle spécifique: l'exemple de la Bolivie

Directory of Open Access Journals (Sweden)

1996-01-01

Full Text Available La modélisation graphique connaît aujourd’hui un essor certain depuis la publication de la Géographie Universelle sous la direction de R. Brunet en France. Les utilisations en sont diverses, qu’elles aient des fins pédagogiques, expérimentales ou prospectives, mais il n’en demeure pas moins qu’à la différence du langage mathématique, la pratique du langage graphique constitue un handicap lorsqu’il s’agit de valider ce type de modèles. Pourtant cette démarche est non seulement possible mais souhaitable, un modèle non validable n’étant plus un modèle. Cependant les tests de validation/vérification et de validation/exploration utilisés pour analyser le modèle de l’espace bolivien sont globalement satisfaisants. LA UTILIZACIÓN DE UN MODELO ESPECÍFICO: EL EJEMPLO DE BOLIVIA. La modelización gráfica tiene en Francia un verdadero desarrollo con la publicación de la Geografía Universal dirigida por R. Brunet. Las utilizaciones son variadas: pedagógicas, experimentales o de investigación pero la práctica del código gráfico es mucho más problemático que la práctica del código matemático cuando se necesita validar un modelo. Sin embargo las pruebas de validación/comprobación y de validación/investigación utilizadas para analizar el modelo del espacio boliviano son bastante satisfactorias. USING SPECIFIC MODELIZATION IN THE CASE OF BOLIVIA. The use of grafic modelization has grown to be acknowledged in France since the publishing of Géographie Universelle edited by R. Brunet. However, in spite of its various applications, whether pedagogical, experimental or prospective, evidence is there to show that graphic models do not as yet compare with mathematical models as regards the validating process. Nonetheless, the two-step testing based on validation/verification and validation/ exploration carried out here on a Bolivian space model does give quite satisfying results.

Adhesion, biofilm formation, cell surface hydrophobicity and antifungal planktonic susceptibility: relationship among Candida spp.

Directory of Open Access Journals (Sweden)

Ana Isabel Silva-Dias

2015-03-01

Full Text Available We have performed the characterization of the adhesion profile, biofilm formation, cell surface hydrophobicity (CSH and antifungal susceptibility of 184 Candida clinical isolates obtained from different human reservoirs. Adhesion was quantified using a flow cytometric assay and biofilm formation was evaluated using two methodologies: XTT and crystal violet assay. CSH was quantified with the microbial adhesion to hydrocarbons test while planktonic susceptibility was assessed accordingly the CLSI protocol for yeast M27-A3 S4.Yeast cells of non-albicans species exhibit increased ability to adhere and form biofilm. However the correlation between adhesion and biofilm formation varied according to species and also with the methodology used for biofilm assessment. No association was found between strain´s site of isolation or planktonic antifungal susceptibility and adhesion or biofilm formation. Finally CSH seemed to be a good predictor for biofilm formation but not for adhesion.Despite the marked variability registered intra and inter species, C. tropicalis and C. parapsilosis were the species exhibiting high adhesion profile. C. tropicalis, C. guilliermondii and C. krusei revealed higher biofilm formation values in terms of biomass. C. parapsilosis was the species with lower biofilm metabolic activity.

Adhesion, biofilm formation, cell surface hydrophobicity, and antifungal planktonic susceptibility: relationship among Candida spp.

Science.gov (United States)

Silva-Dias, Ana; Miranda, Isabel M; Branco, Joana; Monteiro-Soares, Matilde; Pina-Vaz, Cidália; Rodrigues, Acácio G

2015-01-01

We have performed the characterization of the adhesion profile, biofilm formation, cell surface hydrophobicity (CSH) and antifungal susceptibility of 184 Candida clinical isolates obtained from different human reservoirs. Adhesion was quantified using a flow cytometric assay and biofilm formation was evaluated using two methodologies: XTT and crystal violet assay. CSH was quantified with the microbial adhesion to hydrocarbons test while planktonic susceptibility was assessed accordingly the CLSI protocol for yeast M27-A3 S4. Yeast cells of non-albicans species exhibit increased ability to adhere and form biofilm. However, the correlation between adhesion and biofilm formation varied according to species and also with the methodology used for biofilm assessment. No association was found between strain's site of isolation or planktonic antifungal susceptibility and adhesion or biofilm formation. Finally CSH seemed to be a good predictor for biofilm formation but not for adhesion. Despite the marked variability registered intra and inter species, C. tropicalis and C. parapsilosis were the species exhibiting high adhesion profile. C. tropicalis, C. guilliermondii, and C. krusei revealed higher biofilm formation values in terms of biomass. C. parapsilosis was the species with lower biofilm metabolic activity.

Insertion of lead lithium eutectic mixture in RELAP/SCDAPSIM Mod 4.0 for Fusion Reactor Systems

International Nuclear Information System (INIS)

Tiwari, Ashutosh; Allison, Brian; Hohorst, J.K.; Wagner, R.J.; Allison, Chris

2012-01-01

Highlights: ► Thermodynamic and transport properties of lead lithium eutectic mixture have been inserted in RELAP/SCDAPSIM MOD 4.0 code. ► Code results are verified for a simple pipe problem with lead lithium eutectic mixture flowing in it. ► Code is calculating the inserted properties of lead lithium eutectic mixture to a fairly good agreement. - Abstract: RELAP/SCDAPSIM Mod 4.0 code was developed by Innovative System Software (ISS) for the analysis of nuclear power plants (NPPs) cooled by light water and heavy water. Later on the code was expanded to analyze the NPPs cooled by liquid metal, in this sequence: lead bismuth eutectic mixture, liquid sodium and lead lithium eutectic mixture (LLE) are inserted in the code. This paper focuses on the insertion of liquid LLE as a coolant for NPPs in the RELAP/SCDAPSIM Mod 4.0 code. Evaluation of the code was made for a simple pipe problem connected with heat structures having liquid LLE as a coolant in it. The code is predicting well all the thermodynamic and transport properties of LLE.

Flux pinning characteristics of Sn-doped YBCO film by the MOD process

International Nuclear Information System (INIS)

Choi, S.M.; Shin, G.M.; Yoo, S.I.

2013-01-01

Highlights: ► The pinning effects of undoped and Sn-doped YBCO films by MOD were characterized. ► Sn-containing nanoparticles were trapped in Sn-doped YBCO films by MOD. ► Sn-containing nanoparticles were identified as the YBa 2 SnO 5.5 (YBSO) phase by TEM. ► The YBSO nanoparticles are responsible for improved flux pinning effect. ► We report the orientation relationship between YBSO nanoparticles and YBCO matrix. -- Abstract: Compared with the undoped YBa 2 Cu 3 O 7−δ (YBCO) film, 10 mol% Sn-doped YBCO film exhibited significantly enhanced critical current densities (J c ) in magnetic fields up to 5 T at 65 and 77 K for H//c, indicating that the Sn-doped YBCO film possesses more effective flux pinning centers. Both samples were grown on the SrTiO 3 (STO) (1 0 0) single crystal substrates by the metal-organic deposition (MOD) process. Larger J c (77 K, 1 T) values of Sn-doped YBCO film are observed over a wide field-orientation angle (θ) except the field-orientations close to the ab-plane of YBCO (85° c values for 85° 2 SnO 5.5 (YBSO) phase by STEM (scanning transmission electron microscopy)-EDS (energy dispersive X-ray spectroscopy) analysis. Further analyses by HR-TEM (high resolution-transmission electron microscopy) revealed that YBSO nanoparticles completely surrounded by the YBCO matrix had random orientation with YBCO while those located at the interface of YBCO/STO substrate had epitaxial relationship with YBCO

idRHa+ProMod - Rail Hardening Control System

International Nuclear Information System (INIS)

Ferro, L

2016-01-01

idRHa+ProMod is the process control system developed by Primetals Technologies to foresee the thermo-mechanical evolution and micro-structural composition of rail steels subjected to slack quenching into idRHa+ Rail Hardening equipments in a simulation environment. This tool can be used both off-line or in-line, giving the user the chance to test and study the best cooling strategies or letting the automatic control system free to adjust the proper cooling recipe. Optimization criteria have been tailored in order to determine the best cooling conditions according to the metallurgical requirements imposed by the main rail standards and also taking into account the elastoplastic bending phenomena occurring during all stages of the head hardening process. The computational core of idRHa+ProMod is a thermal finite element procedure coupled with special algorithms developed to work out the main thermo-physical properties of steel, to predict the non-isothermal austenite decomposition into all the relevant phases and subsequently to evaluate the amount of latent heat of transformation released, the compound thermal expansion coefficient and the amount of plastic deformation in the material. Air mist and air blades boundary conditions have been carefully investigated by means of pilot plant tests aimed to study the jet impingement on rail surfaces and the cooling efficiency at all working conditions. Heat transfer coefficients have been further checked and adjusted directly on field during commissioning. idRHa+ is a trademark of Primetals Technologies Italy Srl (paper)

idRHa+ProMod - Rail Hardening Control System

Science.gov (United States)

Ferro, L.

2016-03-01

idRHa+ProMod is the process control system developed by Primetals Technologies to foresee the thermo-mechanical evolution and micro-structural composition of rail steels subjected to slack quenching into idRHa+ Rail Hardening equipments in a simulation environment. This tool can be used both off-line or in-line, giving the user the chance to test and study the best cooling strategies or letting the automatic control system free to adjust the proper cooling recipe. Optimization criteria have been tailored in order to determine the best cooling conditions according to the metallurgical requirements imposed by the main rail standards and also taking into account the elastoplastic bending phenomena occurring during all stages of the head hardening process. The computational core of idRHa+ProMod is a thermal finite element procedure coupled with special algorithms developed to work out the main thermo-physical properties of steel, to predict the non-isothermal austenite decomposition into all the relevant phases and subsequently to evaluate the amount of latent heat of transformation released, the compound thermal expansion coefficient and the amount of plastic deformation in the material. Air mist and air blades boundary conditions have been carefully investigated by means of pilot plant tests aimed to study the jet impingement on rail surfaces and the cooling efficiency at all working conditions. Heat transfer coefficients have been further checked and adjusted directly on field during commissioning. idRHa+ is a trademark of Primetals Technologies Italy Srl

Particle size distribution of dust collected from Alcator C-MOD

International Nuclear Information System (INIS)

Gorman, S.V.; Carmack, W.J.; Hembree, P.B.

1998-01-01

There are important safety issues associated with tokamak dust, accumulated primarily from sputtering and disruptions. The dust may contain tritium, it may be activated, chemically toxic, and chemically reactive. The purpose of this paper is to present results from analyses of particulate collected from the Alcator C-MOD tokamak located at Massachusetts Institute of Technology (MIT) in Cambridge, Massachusetts. The sample obtained from C-MOD was not originally intended for examination outside of MIT. The sample was collected with the intent of performing only a composition analysis. However, MIT provided the INEEL with this sample for particle analysis. The sample was collected by vacuuming a section of the machine (covering approximately 1/3 of the machine surface) with a coarse fiber filter as the collection surface. The sample was then analyzed using an optical microscope, SEM microscope, Microtrac FRA particle size analyzer. The data fit a log-normal distribution. The count median diameter (CMD) of the samples ranged from 0.3 microm to 1.1 microm with geometric standard deviations (GSD) ranging from 2.8 to 5.2 and a mass median diameter (MMD) ranging from 7.22 to 176 microm

Detection of Reduced Susceptibility to Chlorfenapyr- and Bifenthrin-Containing Products in Field Populations of the Bed Bug (Hemiptera: Cimicidae).

Science.gov (United States)

Ashbrook, Aaron R; Scharf, Michael E; Bennett, Gary W; Gondhalekar, Ameya D

2017-06-01

Insecticide resistance is a major impediment for effective control of Cimex lectularius L. Previous resistance detection studies with bed bugs have focused on certain pyrethroid, neonicotinoid, organochlorine, organophosphate, and carbamate insecticides. Within the pyrethroid class, resistance studies have mostly been limited to deltamethrin, lambda-cyhalothrin, and alpha- and beta-cyfluthrin. The goal of this study was to develop diagnostic concentration bioassays for assessing bed bug susceptibility levels to chlorfenapyr- and bifenthrin-containing products. First, glass vial and filter paper bioassay methods were compared for their utility in susceptibility monitoring. Statistical comparison of toxicity data between bioassays indicated that the vial assay was less confounded by assay susbtrate effects, required less insecticide, and was faster, especially for chlorfenapyr. Next, using vial diagnostic concentrations (LC99) for each insecticide, 10 laboratory-adapted field strains and the Harlan lab-susceptible strain were screened for susceptibility to chlorfenapyr and bifenthrin. The results of this study reveal recent bed bug susceptibility levels to certain chlorfenapyr- and bifenthrin-containing products. Reduced susceptibility was detected in three and five field strains to chlorfenapyr and bifenthrin, respectively. Detection of reduced susceptibility suggests that certain strains may be segregating toward greater chlorfenapyr and bifenthrin resistance. These results merit continuous resistance monitoring efforts to detect chlorfenapyr and bifenthrin susceptibility shifts. Additionally, to reduce insecticide selection pressures and delay resistance development, adoption of integrated bed bug control strategies that combine chemical and nonchemical methods is recommended. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Combining MOD10A1 and MYD10A1 Images For Snow Cover Area Monitoring

Science.gov (United States)

Tekeli, A. E.

2008-12-01

MOD10A1 and MYD10A1 daily snow cover maps at 500 m resolution are available from MODIS sensors on Terra and Aqua satellites. Aqua obtains the image of same region approximately three hours after Terra over Turkey region. MODIS is an optic sensor and cloud cover degrades the usability of derived snow cover maps. Moreover, spectral similarity between clouds and snow complicates their separability in visible imagery. Fortunately, dynamic behavior of clouds enables their discrimination from snow stationary on the surface. Combined use of MOD10A1 and MYD10A1 images mostly reduces the cloud cover present in one image alone and provides better representation of surface snow cover. Comparison of merged images with in situ data indicated higher hit ratios. The individual comparison of MOD10A1 and MYD10A1 images with ground data each yielded 31% hit ratio whereas, the merged images provided 38%. One-day shifts in comparisons increased hit ratios to 52 % and 46% whereas and two-day shifts gave 77 % and 79 % for MOD10A1 and MYD10A1 respectively. Merged maps yielded 54% and 83% for one and two day shifts. The improvement provided by the merging technique is found to be 7% for the present day, 7 % for one- day and 5% for two-day shifts for the whole season. Monthly decomposition resulted 25% improvement as the maximum. The snow cover product obtained by merging Terra and Aqua satellites provided higher hit ratios, as expected.

Alcator C-Mod predictive modeling

International Nuclear Information System (INIS)

Pankin, Alexei; Bateman, Glenn; Kritz, Arnold; Greenwald, Martin; Snipes, Joseph; Fredian, Thomas

2001-01-01

Predictive simulations for the Alcator C-mod tokamak [I. Hutchinson et al., Phys. Plasmas 1, 1511 (1994)] are carried out using the BALDUR integrated modeling code [C. E. Singer et al., Comput. Phys. Commun. 49, 275 (1988)]. The results are obtained for temperature and density profiles using the Multi-Mode transport model [G. Bateman et al., Phys. Plasmas 5, 1793 (1998)] as well as the mixed-Bohm/gyro-Bohm transport model [M. Erba et al., Plasma Phys. Controlled Fusion 39, 261 (1997)]. The simulated discharges are characterized by very high plasma density in both low and high modes of confinement. The predicted profiles for each of the transport models match the experimental data about equally well in spite of the fact that the two models have different dimensionless scalings. Average relative rms deviations are less than 8% for the electron density profiles and 16% for the electron and ion temperature profiles

Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 4

Science.gov (United States)

1984-01-01

The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator are documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This volume contains 5 books of which this is the fourth, providing drawings 47A380128 through 47A387125. In addition to the parts listing and where-used list, the logic design of the controller software and the code listing of the controller software are provided. Also given are the aerodynamic profile coordinates.

Mod-5A wind turbine generator program design report. Volume 4: Drawings and specifications, book 2

Science.gov (United States)

1984-01-01

The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. There are four volumes. This volume contains the drawings and specifications that were developed in preparation for building the MOD-5A wind turbine generator. This is the second book of volume four. Some of the items it contains are specs for the emergency shutdown panel, specs for the simulator software, simulator hardware specs, site operator terminal requirements, control data system requirements, software project management plan, elastomeric teeter bearing requirement specs, specs for the controls electronic cabinet, and specs for bolt pretensioning.

Progress on MOD/RABiTS{sup TM} 2G HTS wire

Energy Technology Data Exchange (ETDEWEB)

Rupich, M.W.; Zhang, W.; Li, X.; Kodenkandath, T.; Verebelyi, D.T.; Schoop, U.; Thieme, C.; Teplitsky, M.; Lynch, J.; Nguyen, N.; Siegal, E.; Scudiere, J.; Maroni, V.; Venkataraman, K.; Miller, D.; Holesinger, T.G

2004-10-01

The development of the second generation (2G) high temperature superconducting wire has advanced beyond initial laboratory demonstrations and is now focused on developing and testing high critical current conductor designs required for commercial applications. The approach pursued at American Superconductor for 2G wire manufacturing is based on the combination of the RABiTS{sup TM} substrate-buffer technology with metal organic deposition (MOD) of the YBCO layer. This MOD/RABiTS{sup TM} approach has been demonstrated in 10 m lengths with critical currents of up to 184 A/cm-width ({approx}2.3 MA/cm{sup 2}) and in short length with critical currents of up to 270 A/cm-width ({approx}3.4 MA/cm{sup 2}). In addition to a high critical current, the superconducting wire must also meet stringent mechanical and electrical stability requirements that vary by application. Commercially viable architectures designed to meet these specifications have been fabricated and tested. Wires manufactured by this process have been successfully tested in prototype cable and coil applications.

Calculations of flow oscillations during reflood using RELAP4/MOD6

International Nuclear Information System (INIS)

Chen, Y.S.; Fischer, S.R.; Sullivan, L.H.

1979-01-01

RELAP4/MOD6 is an analytical computer code which can be used for best-estimate analysis of LWR reactor system blowdown and reflood response to a postulated LOCA. In this study, flow oscillations in the PKL reflood test K5A were investigated using RELAP4/MOD6. Both calculated and measured oscillations exhibited transient characteristics of density-wave and pressure-drop oscillations. The calculated average core mixture level rising rate agrees closely with the test data. Several mechanisms which appear to be responsible for initiation and continuation of calculated or experimental reflood flow oscillations are (a) the coupling between the vapor generation in the core channel and the U-tube geometrical arrangement of a downcomer and a heated core; (b) the inherent low core inlet resistance and the high system outlet resistance; (c) the dependence of heat transfer rate on mass flow rate especially in the dispersed flow ially in the dispersed flow regime; (d) the amount of the liquid entrainment fraction of the heated core channel

Blow.MOD2: a program for blowdown transient calculations

International Nuclear Information System (INIS)

Doval, A.

1990-01-01

The BLOW.MOD2 program has been developed to calculate the blowdown phase in a pressurized vessel after a break/valve is opened. It is a one volume model where break height and flow area are specified. Moody critical flow model was adopted under saturation conditions for flow calculation through the break. Heat transfer from structures and internals have been taken into account. Long term depressurization results and a more complex model are compared satisfactorily. (Author)

A closed-tube assay for genotyping of the 32-bp deletion polymorphism in the chemokine receptor 5 (CCR5) gene

DEFF Research Database (Denmark)

Rasmussen, Henrik Berg; Werge, Thomas

2007-01-01

We have developed a closed-tube assay for determination of the chemokine receptor type 5 (CCR5) 32-bp deletion allele, which protects against infections with HIV and modulates susceptibility to a variety of inflammatory diseases. This assay utilizes dissociation analysis of amplified products...

Study of the Relap5/mod3.2 wall heat flux partitioning model

International Nuclear Information System (INIS)

Hari, S.; Hassan, Y.A.

2001-01-01

The performance of the subcooled boiling model adapted in RELAP5/MOD3.2 computer code has been assessed in detail for low-pressure conditions and it has been found that the void fraction profile is under-predicted. In general, any subcooled boiling model is composed of individual sub-models that account for the different physical mechanism that govern the overall process, as the wall vapor generation, interfacial shear and condensation etc. The wall heat flux partitioning model is one of the important sub-models that is a constituent of any subcooled boiling model. The function of this model is to apportion the wall heat flux to the different components (as the single/two phase fluid or bubble), as the case may be, in a two-phase flow-boiling scenario adjacent to a heated wall. The ''pumping factor'' approach is generally followed by most of the wall heat flux partitioning models, for partitioning the wall heat flux. In this work, the wall heat flux partitioning model of RELAP5/MOD3.2 computer code is studied; in particular, the ''pumping factor'' formulation in the present code version is assessed for its performance under low-pressure conditions. In addition, three different ''pumping factor'' formulations available in the literature have been introduced into the RELAP5/MOD3.2 code. Simulations of two low-pressure subcooled flow boiling experiments were performed with the refined code versions to determine the appropriate pumping factor to be used under these conditions. (author)

Self-organized 3D equilibrium formation and its feedback control in RFX-mod

International Nuclear Information System (INIS)

Piovesan, P.; Bonfiglio, D.; Marrelli, L.; Soppelsa, A.; Spolaore, M.; Terranova, D.

2014-01-01

The reversed-field pinch exhibits a strong tendency to self-organize into a helical equilibrium as the plasma current is increased. The helical reversed-field pinch is characterized by reduced magnetic stochasticity and by the formation of electron internal transport barriers. The paper gives an update on recent experimental and modelling work on helical states in RFX-mod (Sonato et al 2003 Fusion Eng. Des. 66 161), also discussing similarities with 3D equilibria in tokamaks. The helical equilibrium is modelled with 3D codes developed for stellarators, such as VMEC/V3FIT. The reconstructed safety factor profile has low or reversed magnetic shear in the core, which may be related to transport barrier formation. A significant extension of the RFX-mod database to high current and density confirms the dependence observed before of various helical state properties on macroscopic quantities. Even under conditions where it does not form spontaneously, such as at low current or high density, the 3D magnetic equilibrium can be stimulated and robustly controlled with external fields applied by an extensive set of non axi-symmetric coils. An advanced magnetic feedback algorithm that compensates for error fields induced by eddy currents in the 3D wall structures has been developed. This work stimulated similar experiments in RFX-mod run as a tokamak, where external 3D fields are applied to control a m = 1/n = 1 helical equilibrium. (paper)

Evaluation of the larval migration inhibition assay for detecting macrocyclic lactone resistance in Dirofilaria immitis.

Science.gov (United States)

Evans, Christopher C; Moorhead, Andrew R; Storey, Bobby E; Blagburn, Byron L; Wolstenholme, Adrian J; Kaplan, Ray M

2017-11-15

Anthelmintics of the macrocyclic lactone (ML) drug class are widely used as preventives against the canine heartworm (Dirofilaria immitis). Over the past several years, however, reports of ML lack of efficacy (LOE) have emerged, in which dogs develop mature heartworm infection despite the administration of monthly prophylactics. More recently, isolates from LOE cases have been used to infect laboratory dogs and the resistant phenotype has been confirmed by the establishment of adult worms in the face of ML treatment at normally preventive dosages. Testing for and monitoring resistance in D. immitis requires a validated biological or molecular diagnostic assay. In this study, we assessed a larval migration inhibition assay (LMIA) that we previously optimized for use with D. immitis third-stage larvae (L 3 ). We used this assay to measure the in vitro ML susceptibilities of a known-susceptible laboratory strain of D. immitis and three highly suspected ML-resistant isolates originating from three separate LOE cases; progeny from two of these isolates have been confirmed ML-resistant by treatment of an infected dog in a controlled setting. A nonlinear regression model was fit to the dose-response data, from which IC 50 values were calculated. The D. immitis LMIA yielded consistent and reproducible dose-response data; however, no statistically significant differences in drug susceptibility were observed between control and LOE parasites. Additionally, the drug concentrations needed to paralyze the L 3 were much higher than those third- and fourth-stage larvae would experience in vivo. IC 50 values ranged from 1.57 to 5.56μM (p≥0.19). These data could suggest that ML resistance in this parasite is not mediated through a reduced susceptibility of L 3 to the paralytic effects of ML drugs, and therefore motility-based assays are likely not appropriate for measuring the effects of MLs against D. immitis in this target stage. Published by Elsevier B.V.

Experiment predictions of LOFT reflood behavior using the RELAP4/MOD6 code

International Nuclear Information System (INIS)

Lin, J.C.; Kee, E.J.; Grush, W.H.; White, J.R.

1978-01-01

The RELAP4/MOD6 computer code was used to predict the thermal-hydraulic transient for Loss-of-Fluid Test (LOFT) Loss-of-Coolant Accident (LOCA) experiments L2-2, L2-3, and L2-4. This analysis will aid in the development and assessment of analytical models used to analyze the LOCA performance of commercial power reactors. Prior to performing experiments in the LOFT facility, the experiments are modeled in counterpart tests performed in the nonnuclear Semiscale MOD 1 facility. A comparison of the analytical results with Semiscale data will verify the analytical capability of the RELAP4 code to predict the thermal-hydraulic behavior of the Semiscale LOFT counterpart tests. The analytical model and the results of analyses for the reflood portion of the LOFT LOCA experiments are described. These results are compared with the data from Semiscale

PL-MOD: a computer code for modular fault tree analysis and evaluation

International Nuclear Information System (INIS)

Olmos, J.; Wolf, L.

1978-01-01

The computer code PL-MOD has been developed to implement the modular methodology to fault tree analysis. In the modular approach, fault tree structures are characterized by recursively relating the top tree event to all basic event inputs through a set of equations, each defining an independent modular event for the tree. The advantages of tree modularization lie in that it is a more compact representation than the minimal cut-set description and in that it is well suited for fault tree quantification because of its recursive form. In its present version, PL-MOD modularizes fault trees and evaluates top and intermediate event failure probabilities, as well as basic component and modular event importance measures, in a very efficient way. Thus, its execution time for the modularization and quantification of a PWR High Pressure Injection System reduced fault tree was 25 times faster than that necessary to generate its equivalent minimal cut-set description using the computer code MOCUS

Investigation of the critical edge ion heat flux for L-H transitions in Alcator C-Mod and its dependence on B T

Science.gov (United States)

Schmidtmayr, M.; Hughes, J. W.; Ryter, F.; Wolfrum, E.; Cao, N.; Creely, A. J.; Howard, N.; Hubbard, A. E.; Lin, Y.; Reinke, M. L.; Rice, J. E.; Tolman, E. A.; Wukitch, S.; Ma, Y.; ASDEX Upgrade Team; Alcator C-Mod Team

2018-05-01

This paper presents investigations on the role of the edge ion heat flux for transitions from L-mode to H-mode in Alcator C-Mod. Previous results from the ASDEX Upgrade tokamak indicated that a critical value of edge ion heat flux per particle is needed for the transition. Analysis of C-Mod data confirms this result. The edge ion heat flux is indeed found to increase linearly with density at given magnetic field and plasma current. Furthermore, the Alcator C-Mod data indicate that the edge ion heat flux at the L-H transition also increases with magnetic field. Combining the data from Alcator C-Mod and ASDEX Upgrade yields a general expression for the edge ion heat flux at the L-H transition. These results are discussed from the point of view of the possible physics mechanism of the L-H transition. They are also compared to the L-H power threshold scaling and an extrapolation for ITER is given.

RELOS.MOD2: a code system for the determination of instationary fission product releases from molten pools

International Nuclear Information System (INIS)

Kortz, Ch.; Koch, M.K.; Unger, H.; Funke, F.

1999-01-01

For the assessment of molten corium pool source terms, a mechanistic model has been developed to describe the transport of fission products from liquid corium pool surfaces into a colder gas atmosphere. Modelling is based on an approach for diffusive and convective transport processes coupled with thermochemical equilibrium considerations enabling detailed speciation analyses of the fission products released. Both have been implemented into the code system RELOS.MOD2. RELOS.MOD2 sensitivity calculations on possible effects of anticipated uncertainties in the thermo-chemical data on the fission product release predictions are presented. (author)

Upgrade of the RFX-mod real time control system

International Nuclear Information System (INIS)

Manduchi, G.; Barbalace, A.; Luchetta, A.; Soppelsa, A.; Taliercio, C.; Zampiva, E.

2012-01-01

Highlights: ► The paper describes the experience in running the real-time control system of RFX-mod. ► It proposes a new architecture based multicore technology. ► It analyzes two different solutions for data acquisition. ► It discusses the effect of non simultaneous sampling in acquisition. ► It provides some preliminary performance measurements. - Abstract: The real-time control system of RFX-mod, in operation since 2005, has been successful and has allowed several important achievements in the RFX physics research program. As a consequence of this fact, new control algorithms are under investigation, which are more demanding in terms of both enhanced computing power and reduced system latency, currently around 1.5 ms. For this reason, a major upgrade of the system is being considered, and a new architecture has been proposed, taking advantage of the rapid evolution of computer technology in the last years. The central component of the new architecture is a Linux-based multicore server, where individual cores replace the VME computers. The server is connected to the I/O via PCI-e based bus extenders, and every PCI-e connection is managed by a separate core. The system is supervised by MARTe, a software framework for real-time applications written in C++ and developed at JET and currently used for the JET vertical stabilization and in other fusion devices.

Control of substrate oxidation in MOD ceramic coating on low-activation ferritic steel with reduced-pressure atmosphere

Energy Technology Data Exchange (ETDEWEB)

Tanaka, Teruya, E-mail: teru@nifs.ac.jp; Muroga, Takeo

2014-12-15

Highlights: • A Cr{sub 2}O{sub 3} layer was produced on a ferritic steel substrate with a reduced-pressure. • The Cr{sub 2}O{sub 3} layer prevents further substrate oxidation in following coating process. • The Cr{sub 2}O{sub 3} layer has a function as a hydrogen permeation barrier. • A smooth MOD Er{sub 2}O{sub 3} coating was successfully made on the Cr{sub 2}O{sub 3} layer by dip coating. • The Cr{sub 2}O{sub 3} layer would enhance flexibility in MOD coating process and performances. - Abstract: An Er{sub 2}O{sub 3} ceramic coating fabricated using the metal–organic decomposition (MOD) method on a Cr{sub 2}O{sub 3}-covered low-activation ferritic steel JLF-1 substrate was examined to improve hydrogen permeation barrier performance of the coating. The Cr{sub 2}O{sub 3} layer was obtained before coating by heat treating the substrate at 700 °C under reduced pressures of <5 × 10{sup −3} Pa and 5 Pa. The Cr{sub 2}O{sub 3} layer was significantly stable even with heat treatment at 700 °C in air. This layer prevented further production of Fe{sub 2}O{sub 3}, which has been considered to degrade coating performance. An MOD Er{sub 2}O{sub 3} coating with a smooth surface was successfully obtained on a Cr{sub 2}O{sub 3}-covered JLF-1 substrate by dip coating followed by drying and baking. Preprocessing to obtain a Cr{sub 2}O{sub 3} layer would provide flexibility in the coating process for blanket components and ducts. Moreover, the Cr{sub 2}O{sub 3} layer suppressed hydrogen permeation through the JLF-1 substrate. While further optimization of the coating fabrication process is required, it would be possible to suppress hydrogen permeation significantly by multilayers of Cr{sub 2}O{sub 3} and MOD oxide ceramic.

Blob sizes and velocities in the Alcator C-Mod scrape-off layer

DEFF Research Database (Denmark)

Kube, R.; Garcia, O.E.; LaBombard, B.

A new blob-tracking algorithm for the GPI diagnostic installed in the outboard-midplane of Alcator C-Mod is developed. I t tracks large-amplitude fluctuations propagating through the scrape-off layer and calculates blob sizes and velocities. We compare the results of this method to a blob velocity...

Application of RELAP5/MOD3.1 code to the LOFT test L3-6

International Nuclear Information System (INIS)

Pylev, S.S.; Roginskaja, V.L.

1998-02-01

A calculation of LOFT Experiment L3-6, a small break equivalent to a 4-in diameter rupture in the cold leg of a four-loop commercial pressurized water reactor, has been performed to help validate RELAP5/MOD3.1 for this application. The version of the code to be used is SCDAP/RELAP5/MOD3.1.8d0. Three calculations were carried out in order to study the sensitivity to change break nozzle superheated discharge coefficient. Conducted comparative analysis of the LOFT L3-6 experiment shows on the whole a reasonable agreement between calculated data. Some discrepancies in the system pressure do not distort a picture of the transient. 6 refs

Application of RELAP5/MOD3.1 code to the LOFT test L3-6

Energy Technology Data Exchange (ETDEWEB)

Pylev, S.S.; Roginskaja, V.L.

1998-02-01

A calculation of LOFT Experiment L3-6, a small break equivalent to a 4-in diameter rupture in the cold leg of a four-loop commercial pressurized water reactor, has been performed to help validate RELAP5/MOD3.1 for this application. The version of the code to be used is SCDAP/RELAP5/MOD3.1.8d0. Three calculations were carried out in order to study the sensitivity to change break nozzle superheated discharge coefficient. Conducted comparative analysis of the LOFT L3-6 experiment shows on the whole a reasonable agreement between calculated data. Some discrepancies in the system pressure do not distort a picture of the transient. 6 refs.

Modeling of BWR core meltdown accidents - for application in the MELRPI. MOD2 computer code

Energy Technology Data Exchange (ETDEWEB)

Koh, B R; Kim, S H; Taleyarkhan, R P; Podowski, M Z; Lahey, Jr, R T

1985-04-01

This report summarizes improvements and modifications made in the MELRPI computer code. A major difference between this new, updated version of the code, called MELRPI.MOD2, and the one reported previously, concerns the inclusion of a model for the BWR emergency core cooling systems (ECCS). This model and its computer implementation, the ECCRPI subroutine, account for various emergency injection modes, for both intact and rubblized geometries. Other changes to MELRPI deal with an improved model for canister wall oxidation, rubble bed modeling, and numerical integration of system equations. A complete documentation of the entire MELRPI.MOD2 code is also given, including an input guide, list of subroutines, sample input/output and program listing.

Rapid, radiolabeled-microculture method that uses macrophages for in vitro evaluation of Mycobacterium leprae viability and drug susceptibility.

Science.gov (United States)

Mittal, A; Sathish, M; Seshadri, P S; Nath, I

1983-04-01

This paper describes a microculture rapid assay using radiolabeling and mouse macrophages to determine the viability and the drug susceptibility or resistance of Mycobacterium leprae. Comparison of M. leprae resident macrophage cultures maintained in 96-well flat-bottomed plates showed results for viability and susceptibility or resistance to dapsone that were similar to results for concurrent cultures in Leighton tubes with greater numbers of bacilli and macrophages.

Rapid, Radiolabeled-Microculture Method That Uses Macrophages for In Vitro Evaluation of Mycobacterium leprae Viability and Drug Susceptibility

OpenAIRE

Mittal, A.; Sathish, M.; Seshadri, P. S.; Nath, Indira

1983-01-01

This paper describes a microculture rapid assay using radiolabeling and mouse macrophages to determine the viability and the drug susceptibility or resistance of Mycobacterium leprae. Comparison of M. leprae resident macrophage cultures maintained in 96-well flat-bottomed plates showed results for viability and susceptibility or resistance to dapsone that were similar to results for concurrent cultures in Leighton tubes with greater numbers of bacilli and macrophages.

Transport and confinement studies in the RFX-mod reversed-field pinch experiment

International Nuclear Information System (INIS)

Innocente, P.; Alfier, A.; Carraro, L.; Lorenzini, R.; Pasqualotto, R.; Terranova, D.

2007-01-01

In the modified RFX experiment (RFX-mod) external magnetic field coils and a close fitting thin conductive shell control radial magnetic fields. In the so-called virtual shell (VS) operation, radial field zeroing at the thin shell radius is stationary provided by the feedback-controlled coils. First experiments on RFX-mod proved the capability of the active scheme to steadily reduce the radial magnetic field. Furthermore it has been found that such edge magnetic field control extends its beneficial effects to the whole plasma. With respect to the old RFX, where magnetohydrodynamic modes amplitude was controlled by the use of a passive thick conductive shell, a stationary 2- to 3-fold reduction of the B r field amplitude in the core is obtained. The reduction of field fluctuations positively reflects on confinement. In fact, a strong reduction of the loop voltage is observed and correspondingly a 3-fold increase in pulse length is achieved by using the same poloidal flux swing. Temperature and particle measurements confirm the improved confinement properties of the VS operation. With a lower ohmic input power, higher electron temperature and lower particle influx are measured. Particle and heat transport have been studied by means of a 1D code. Local power balance was used to compute the heat conductivity profile: for the VS discharges a lower conductivity over a significant region of the plasma is found. The improved properties of RFX-mod VS operation provide a better confinement scaling in terms of plasma current. The results show that compared with the thick shell configuration, a significant confinement improvement can be obtained under stationary conditions by actively controlling the plasma magnetic boundary

Tableaux et modèles: «vive la sintayse»

Directory of Open Access Journals (Sweden)

Christian GERMANAZ

1994-09-01

Full Text Available L’image géographique et la peinture présentent beaucoup de similitudes. Il est possible d’analyser l’image picturale sous l’angle de la modélisation. Par l’intermédiaire de la chorématique une équivalence dans le langage plastique et pictural a été trouvée Le Christ jaune de Gauguin permet de tester cette transposition.

Response to challenging dose of x-rays as a predictive assay for molecular epidemiology

International Nuclear Information System (INIS)

Cebulska-Wasilewska, A.

2003-01-01

Human biomonitoring, as a tool to identify or quantify the potential risk from genotoxic exposures, has gained increasing interest especially in the areas of cancer risk assessment and diseases treatment. Chromosome aberrations resulting from direct DNA breakage or from inhibition of DNA repair or synthesis, measured in peripheral blood lymphocytes have been used in occupational health surveillance programs in order to assess risks from exposures. Many results in our human monitoring studies have shown influence of the environmental or occupational exposure on the cytogenetic damage detected in lymphocytes, confirming both, the association with adverse health outcome and the influence of life style related confounding factors. Susceptibility to the environmental agent actions was also evaluated in lymphocytes in the studies of variation between responses to the challenging dose of UV or X-rays followed by the evaluation of the repair capacity of the DNA damage induced by a challenging dose. The induced and residual DNA damage was analyzed with the use of SCGE assay. Susceptibility and repair capacities of healthy donors and cancer patients were compared. Studies have shown a good correlation between DNA damage induced in vivo or in vitro and cytogenetic measures. Results from studies on susceptibilities and repair competence performed in occupationally exposed and unexposed 475 healthy donors and patients with diagnosed cancer are discussed. Significantly lower efficiency of repair process was observed in cancer patients. The possible effects on repair competency of various occupational exposures and influence of the diet and other confounding factors is shown. Although in our preliminary studies comet assay failed to detect DNA damage repair disorders in a teratoma immature infant, though, prospective use of a challenging dose of radiation combined with the comet assay as a predictive assay is suggested and limitation discussed

RELAP5/MOD 3.3 analysis of Reactor Coolant Pump Trip event at NPP Krsko

International Nuclear Information System (INIS)

Bencik, V.; Debrecin, N.; Foretic, D.

2003-01-01

In the paper the results of the RELAP5/MOD 3.3 analysis of the Reactor Coolant Pump (RCP) Trip event at NPP Krsko are presented. The event was initiated by an operator action aimed to prevent the RCP 2 bearing damage. The action consisted of a power reduction, that lasted for 50 minutes, followed by a reactor and a subsequent RCP 2 trip when the reactor power was reduced to 28 %. Two minutes after reactor trip, the Main Steam Isolation Valves (MSIV) were isolated and the steam dump flow was closed. On the secondary side the Steam Generator (SG) pressure rose until SG 1 Safety Valve (SV) 1 opened. The realistic RELAP5/MOD 3.3 analysis has been performed in order to model the particular plant behavior caused by operator actions. The comparison of the RELAP5/MOD 3.3 results with the measurement for the power reduction transient has shown small differences for the major parameters (nuclear power, average temperature, secondary pressure). The main trends and physical phenomena following the RCP Trip event were well reproduced in the analysis. The parameters that have the major influence on transient results have been identified. In the paper the influence of SG 1 relief and SV valves on transient results was investigated more closely. (author)

From the Last Interglacial to the Anthropocene: Modelling a Complete Glacial Cycle (PalMod)

Science.gov (United States)

Brücher, Tim; Latif, Mojib

2017-04-01

We will give a short overview and update on the current status of the national climate modelling initiative PalMod (Paleo Modelling, www.palmod.de). PalMod focuses on the understanding of the climate system dynamics and its variability during the last glacial cycle. The initiative is funded by the German Federal Ministry of Education and Research (BMBF) and its specific topics are: (i) to identify and quantify the relative contributions of the fundamental processes which determined the Earth's climate trajectory and variability during the last glacial cycle, (ii) to simulate with comprehensive Earth System Models (ESMs) the climate from the peak of the last interglacial - the Eemian warm period - up to the present, including the changes in the spectrum of variability, and (iii) to assess possible future climate trajectories beyond this century during the next millennia with sophisticated ESMs tested in such a way. The research is intended to be conducted over a period of 10 years, but with shorter funding cycles. PalMod kicked off in February 2016. The first phase focuses on the last deglaciation (app. the last 23.000 years). From the ESM perspective PalMod pushes forward model development by coupling ESM with dynamical ice sheet models. Computer scientists work on speeding up climate models using different concepts (like parallelisation in time) and one working group is dedicated to perform a comprehensive data synthesis to validate model performance. The envisioned approach is innovative in three respects. First, the consortium aims at simulating a full glacial cycle in transient mode and with comprehensive ESMs which allow full interactions between the physical and biogeochemical components of the Earth system, including ice sheets. Second, we shall address climate variability during the last glacial cycle on a large range of time scales, from interannual to multi-millennial, and attempt to quantify the relative contributions of external forcing and processes

Application of a MODIS Soil Moisture-Evapotranspiration (MOD-SMET) Model to Evaluate Landscape and Hydrologic Recovery after the High Park Fire in Colorado, USA

Science.gov (United States)

Blount, W. K.; Hogue, T. S.; Franz, K.; Knipper, K. R.

2017-12-01

Accurate estimation of evapotranspiration (ET) is critical for the management of water resources, especially in water-stressed regions. ET accounts for approximately 60% of terrestrial precipitation globally and approaches 100% of annual rainfall in arid ecosystems, where transpiration becomes the dominant term. ET is difficult to measure due to its spatiotemporal variation, which requires adequate data coverage. While new remote sensing-based ET products are available at a 1 km spatial resolution, including the Operational Simplified Surface Energy Balance model (SSEBop) and the MODIS Global Evapotranspiration Project (MOD16), these products are available at monthly and 8-day temporal resolutions, respectively. To better understand the changing dynamics of hydrologic fluxes and the partitioning of water after land cover disturbances and to identify statically significant trends, more frequent observations are necessary. Utilizing the recently developed MODIS Soil Moisture-Evapotranspiration (MOD-SMET) model, daily temporal resolution is achieved. This presentation outlines the methodology of the MOD-SMET model and compares SSEBop, MOD16, and MOD-SMET ET estimates over the High Park Fire burn scar in Colorado, USA. MOD-SMET estimates are used to identify changes in fluxes and partitioning of the water cycle after a wildfire and during recovery in the High Park Fire near Fort Collins, Colorado. Initial results indicate greenness and ET from all three models decrease post-fire, with higher statistical confidence in high burn areas and spatial patterns that closely align with burn severity. MOD-SMET improves the ability to resolve statistically significant changes in ET following wildfires and better understand changes in the post-fire water budget. Utilizing this knowledge, water resource managers can better plan for, and mitigate, the short- and long-term impacts of wildfire on regional water supplies.

Use of Pinus sylvestris L. (Pinaceae), Origanum vulgare L. (Lamiaceae), and Thymus vulgaris L. (Lamiaceae) essential oils and their main components to enhance itraconazole activity against azole susceptible/not-susceptible Cryptococcus neoformans strains.

Science.gov (United States)

Scalas, Daniela; Mandras, Narcisa; Roana, Janira; Tardugno, Roberta; Cuffini, Anna Maria; Ghisetti, Valeria; Benvenuti, Stefania; Tullio, Vivian

2018-05-03

Cryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients. In addition, the lower susceptibility of this yeast to azoles is a growing problem in health care. To date, there are very few molecules with any activity towards Cryptococcus neoformans, leading to heightened interest in finding new alternatives or adjuvants to conventional drugs for the treatment of mycosis caused by this yeast. Since the essential oils (EOs) are considered as a potential rich source of bioactive antimicrobial compounds, we evaluated the antifungal activity of Origanum vulgare (oregano), Pinus sylvestris (pine), and Thymus vulgaris (thyme red) EOs, and their components (α-pinene, carvacrol, thymol) compared with fluconazole, itraconazole, and voriconazole, against C.neoformans clinical strains. Then, we investigated the effect of EOs and components in combination with itraconazole. EO composition was analysed by Gas chromatography-mass spectrometry (GC-MS). A broth microdilution method was used to evaluate the susceptibility of C.neoformans to azoles, EOs and components. Checkerboard tests, isobolograms and time-kill assays were carried out for combination studies. Six C.neoformans isolates were susceptible to azoles, while one C.neoformans exhibited a reduced susceptibility to all tested azole drugs. All EOs exerted a good inhibitory activity against all C.neoformans strains. Pine EO was the most effective. Among components, thymol exerted the most remarkable activity. By checkerboard testing and isobolographic analysis, combinations of itraconazole with oregano, pine, or thyme EOs, and carvacrol were found to be synergistic (FICI≤0.5) against azole susceptible C.neoformans. Regarding the azole not susceptible C.neoformans strain, the synergistic effect with itraconazole was observed with thyme EO (chemotype: thymol 26.52%; carvacrol 7.85%), and carvacrol. Time-kill assays confirmed the synergistic

Molybdenum erosion measurements in Alcator C-Mod

Energy Technology Data Exchange (ETDEWEB)

Wampler, W.R. [Sandia National Labs., Albuquerque, NM (United States); LaBombard, B.; Lipshultz, B.; Pappas, D.; Pitcher, C.S. [Massachusetts Inst. of Tech., Cambridge, MA (United States); McCracken, G.M. [JET Joint Undertaking, Abingdon (United Kingdom)

1998-05-01

Erosion of molybdenum was measured on a set of 21 tiles after a run campaign of 1,090 shots in the Alcator C-Mod tokamak. The net erosion of molybdenum, was determined from changes in the depth of a thin chromium marker layer measured by Rutherford backscattering. Net Mo erosion was found to be approximately 150 nm near the outer divertor strike point, and much less everywhere else. Gross erosion rates by sputtering were estimated using ion energies and fluxes obtained from Langmuir probe measurements of edge-plasma conditions. Predicted net erosion using calculated gross erosion with prompt redeposition and measured net erosion agree within a factor of 3. Sputtering by boron and molybdenum impurities dominates erosion.

Mods and Rockers, Drunken Debutants, and Sozzled Students

Directory of Open Access Journals (Sweden)

Bill Thompson

2012-07-01

Full Text Available Over the last decade, moral panic theory has affected a paradigm shift in the social construction of deviance and social problems in the United States, without any real debate about its viability. This article raises key questions about this perspective by offering the first ever critique of the seminal case study of British youth subcultures on which the paradigm is based. It argues that when analyzed in the context of contemporary criticism of vandalism, hooliganism, and delinquency, the Mods and Rockers case study never justified Cohen’s original criteria for a moral panic.

Fatigue impact on Mod-1 wind turbine design

Science.gov (United States)

Stahle, C. V., Jr.

1978-01-01

Fatigue is a key consideration in the design of a long-life Wind Turbine Generator (WTG) system. This paper discusses the fatigue aspects of the large Mod-1 horizontal-axis WTG design starting with the characterization of the environment and proceeding through the design. Major sources of fatigue loading are discussed and methods of limiting fatigue loading are described. NASTRAN finite element models are used to determine dynamic loading and internal cyclic stresses. Recent developments in determining the allowable fatigue stress consistent with present construction codes are discussed relative to their application to WTG structural design.

Transport and Stability in C-Mod ITBs in Diverse Regimes

Science.gov (United States)

Fiore, C. L.; Ernst, D. R.; Howard, N. T.; Kasten, C. P.; Mikkelsen, D.; Reinke, M. L.; Rice, J. E.; White, A. E.; Rowan, W. L.; Bespamyatnov, I.

2012-10-01

Internal Transport Barriers (ITBs) in C-Mod feature highly peaked density and pressure profiles and are typically induced by the introduction of radio frequency power in the ion cyclotron range of frequencies (ICRF) with the second harmonic of the resonance for minority hydrogen ions positioned off-axis at the plasma half radius on either the low or high field side of the plasma. These ITBs are formed in the absence of particle or momentum injection, and with monotonic q profiles with qminITB dynamics in a reactor relevant regime. Recently, linear and non-linear gyrokinetic simulations have demonstrated that changes in the ion temperature and plasma rotation profiles, coincident with the application of off-axis ICRF heating, contribute to greater stability to ion temperature gradient driven fluctuation in the plasma. This results in reduced turbulent driven outgoing heat flux. To date, ITB formation in C-Mod has only been observed in EDA H-mode plasmas with moderate (2-3 MW) ICRF power. Experiments to explore the formation of ITBs in other operating regimes such as I-mode and also with high ICRF power are being undertaken to understand further the process of ITB formation and sustainment, especially with regard to turbulent driven transport.

RELAP4/MOD6 reflood heat transfer and data comparison

International Nuclear Information System (INIS)

Nelson, R.A.; Sullivan, L.H.

1981-01-01

This discussion of RELAP4/MOD6 will be limited to the reflood heat transfer models and evaluation of these models by comparison of calculation with results from three reflood experiments. The discussion of the model includes the heat transfer surface concept, the heat transfer correlations, the superheat model and the entrainment model which presents both the two-phase heat transfer and hydraulic models. In the discussion of the reflood heat transfer, the mathematical concept of a multidimensional surface is used to represent the heat flux of a given heat transfer correlation or correlations dependent upon such variables as quality, wall superheat and flux. This concept has been used to investigate the characteristics of the correlations, which are discusssed in detail, and the way they are applied to the two-phase mixture. Of primary importance in the reflood core heat transfer is the consideration of thermal nonequilibrium between the phases and the liquid entrainment, and its distribution up the core. Results obtained to date show the heat transfer and hydraulics to be closely coupled. Comparison of the RELAP4/MOD6 reflood calculations with the data from the forced feed FLECHT and gravity feed FLECHT-SET and Semiscale reflood experiments indicates that the heat transfer and hydraulic models are operational and yield good results

Méditerranée asiatique : un modèle urbain polycentrique

OpenAIRE

Gipouloux , François

2012-01-01

Publication de la revue "Diplomatie. Affaires stratégiques et relations internationales" http://www.diplomatie-presse.com/; International audience; En Asie orientale, un corridor maritime a pris forme autour de plates-formes logistiques et portuaires, fidèles au modèle de Hong Kong. C'est là que bat le coeur de l'économie régionale.

MOD-1 Wind Turbine Generator Analysis and Design Report, Volume 2

Science.gov (United States)

1979-01-01

The MOD-1 detail design is appended. The supporting analyses presented include a parametric system trade study, a verification of the computer codes used for rotor loads analysis, a metal blade study, and a definition of the design loads at each principal wind turbine generator interface for critical loading conditions. Shipping and assembly requirements, composite blade development, and electrical stability are also discussed.

Tungsten impurity transport experiments in Alcator C-Mod to address high priority research and development for ITER

Energy Technology Data Exchange (ETDEWEB)

Loarte, A.; Polevoi, A. R.; Hosokawa, M. [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Reinke, M. L. [York Plasma Institute, Department of Physics, University of York, Heslington, York YO10 5DD (United Kingdom); Chilenski, M.; Howard, N.; Hubbard, A.; Hughes, J. W.; Rice, J. E.; Walk, J. [Plasma Science and Fusion Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Köchl, F. [Technische Universität Wien, Atominstitut, Stadionallee 2, 1020 Vienna (Austria); Pütterich, T.; Dux, R. [Max-Planck-Institut für Plasmaphysik, Boltzmanstraße 2, D-85748 Garching (Germany); Zhogolev, V. E. [NRC “Kurchatov Institute,” Kurchatov Square 1, 123098 Moscow (Russian Federation)

2015-05-15

Experiments in Alcator C-Mod tokamak plasmas in the Enhanced D-alpha H-mode regime with ITER-like mid-radius plasma density peaking and Ion Cyclotron Resonant heating, in which tungsten is introduced by the laser blow-off technique, have demonstrated that accumulation of tungsten in the central region of the plasma does not take place in these conditions. The measurements obtained are consistent with anomalous transport dominating tungsten transport except in the central region of the plasma where tungsten transport is neoclassical, as previously observed in other devices with dominant neutral beam injection heating, such as JET and ASDEX Upgrade. In contrast to such results, however, the measured scale lengths for plasma temperature and density in the central region of these Alcator C-Mod plasmas, with density profiles relatively flat in the core region due to the lack of core fuelling, are favourable to prevent inter and intra sawtooth tungsten accumulation in this region under dominance of neoclassical transport. Simulations of ITER H-mode plasmas, including both anomalous (modelled by the Gyro-Landau-Fluid code GLF23) and neoclassical transport for main ions and tungsten and with density profiles of similar peaking to those obtained in Alcator C-Mod show that accumulation of tungsten in the central plasma region is also unlikely to occur in stationary ITER H-mode plasmas due to the low fuelling source by the neutral beam injection (injection energy ∼ 1 MeV), which is in good agreement with findings in the Alcator C-Mod experiments.

De Bronislaw Malinowski à Virginia Henderson: révélation sur l'origine anthropologique d'un modèle de soins infirmiers

Directory of Open Access Journals (Sweden)

NICOLAS VONARX

2010-10-01

Full Text Available Le modèle des quatorze besoins fondamentaux de Virginia Henderson est sûrement le plus populaire des modèles de soins chez les infirmières d'ici et d'ailleurs. Par contre, son origine et les grandes inspirations d'Henderson dans l'élaboration de son modèle sont mal connues. Ce texte lève en quelque sorte le voile à ce sujet en montrant que ce modèle trouve sa source en anthropologie et qu'il entretient de très fortes correspondances avec les éléments clefs retrouvés dans les travaux de l'anthropologue Malinowski. En retraçant et en revenant sur ces correspondances, voire sur les emprunts qu'aurait faits Henderson des travaux de Malinowski, nous trouvons dans ce texte une bonne occasion de souligner la part des savoirs empruntés, et notamment des savoirs anthropo-sociologiques, au sein de la discipline infirmière.

Thermal fatigue crack growth tests and analyses of thick wall cylinder made of Mod.9Cr–1Mo steel

Energy Technology Data Exchange (ETDEWEB)

Wakai, Takashi, E-mail: wakai.takashi@jaea.go.jp [Japan Atomic Energy Agency, 4002 Narita-cho Oarai, Ibaraki 3111393 (Japan); Inoue, Osamu [IX Knowledge Inc., 3-22-23 MSC Center Bldg, Kaigan Minato-ku, Tokyo 1080022 Japan (Japan); Ando, Masanori; Kobayashi, Sumio [Japan Atomic Energy Agency, 4002 Narita-cho Oarai, Ibaraki 3111393 (Japan)

2015-12-15

Highlights: • A thermal fatigue crack growth test was performed using Mod.9Cr–1Mo steel cylinder. • Axial/circumferential notches were machined on the inner surface of the cylinder. • Simplified analytical results were compared to the test data. • Crack length could not be predicted by the analyses because of crack conjunctions. • If there are no surface cracks, the calculations might agree with the observations. - Abstract: In Japan, the basic designing works for a demonstration plant of Japan Sodium cooled Fast Reactor (JSFR) are now conducted. JSFR is an advanced loop type reactor concept. To enhance the safety and the economic competitiveness, JSFR employs modified 9% chromium–1% molybdenum (Mod.9Cr–1Mo) steel as a material for coolant pipes and components, because the steel has both excellent high temperature strength and thermal properties. The steel has been standardized as a nuclear material in Japan Society of Mechanical Engineers (JSME) code in 2012. In JSFR pipes, demonstration of Leak Before Break (LBB) aspect is strongly expected because the safety assessment may be performed on the premise of leak rate where the LBB aspect is assured. Although the authors have already performed a series of thermal fatigue crack growth tests of austenitic stainless steel cylinders (Wakai et al., 2005), crack growth behavior in the structures made of Mod.9Cr–1Mo steel has not been investigated yet. Especially for the welded joints of Mod.9Cr–1Mo steel, “Type-IV” cracking may occur at heat affected zone (HAZ). Therefore, this study performed a series of thermal fatigue crack growth tests of thick wall cylinders made of Mod.9Cr–1Mo steel including welds, to obtain the crack growth data under cyclic thermal transients. The test results were compared to the analytical results obtained from JAEA's simplified methods (Wakai et al., 2005).

Evaluation of a radiometric method for pyrazinamide susceptibility testing of Mycobacterium tuberculosis

International Nuclear Information System (INIS)

Tarrand, J.J.; Spicer, A.D.; Groeschel, D.H.

1986-01-01

Pyrazinamide susceptibility testing of Mycobacterium tuberculosis requires an acid environment. By controlling the method of acidification and the quality and quantity of the inoculum, the test can be performed with the BACTEC radiometric system (Johnston Laboratories, Towson, Md.). We acidified BACTEC 7H12 medium with buffered phosphoric acid and adjusted the test inoculum to 1/10 of that usually employed in BACTEC protocols; after 5 days of growth we correctly identified 36 of 36 strains susceptible to 50 micrograms of pyrazinamide per ml. All 18 resistant strains were classified as pyrazinamide resistant. (Susceptibility or resistance had been determined by standard plate assays.) The test was able to detect small resistant populations in artificial mixtures of 1 or 2% resistant bacteria with a susceptible strain (10 mixtures each). We tested 70 M. tuberculosis strains in acidified BACTEC 7H12 medium and by the plate dilution test at pH 5.5. All strains grew in the BACTEC medium, but three strains failed to grow on plates and were not tested further; the results of both methods agreed for the remaining strains

Developmental assessment of RELAP5/MOD3 code against ROSA-IV/TPTF horizontal two-phase flow experiments

International Nuclear Information System (INIS)

Kukita, Yutaka; Asaka, Hideaki; Anoda, Yoshinari; Ishiguro, Misako; Tasaka, Kanji; Mimura, Yuichi; Nemoto, Toshiyuki.

1990-03-01

A developmental version of the RELAP5/Mod3 code (as of June 1989) was assessed for accuracy using experimental data taken for high-pressure (7MPa) steam-water two-phase flow in a large-diameter (0.18 m) horizontal-pipe test section of the ROSA-IV Two-Phase Flow Test Facility (TPTF). The agreement between the measured and calculated test section void fractions was much better than that for the previous generation of RELAP5 (MOD2). The improvement was achieved primarily due to the code changes with respect to the flow stratification criterion and interfacial-drag calculation scheme. (author)

Assessment of TRAC-BD1/MOD1 using FIST data

International Nuclear Information System (INIS)

Jo, J.H.; Connell, H.R.

1985-01-01

This report is concerned with the assessment of the TRAC-BD1/MOD1 Code, developed at Idaho National Engineering Laboratory. The assessment was conducted using data from the FIST (Full Integral Simulation Test) facility, which is a BWR safety test facility which was built to investigate small break LOCA and operational transients in BWR's and to complement earlier large break LOCA test results from TLTA (Two-Loop Test Apparatus). 21 figs

MOD/R : A knowledge assisted approach towards top-down only CMOS VLSI design

NARCIS (Netherlands)

Spaanenburg, L.; Beunder, M.; Beune, F.A.; Gerez, Sabih H.; Holstein, B.; Luchtmeyer, R.C.C.; Smit, Jaap; van der Werf, A.; Willems, H.

1985-01-01

MOD/R models all views on the design space in relations. This is achieved by eliminating the package constraints, as are apparent in PCB oriented hardware description languages. Assisted by knowledge engineering it allows for a top-down, mostly hierarchical decomposition, virtually eliminating the

Design and operation of the RFX-mod plasma shape control system

Energy Technology Data Exchange (ETDEWEB)

Marchiori, G., E-mail: giuseppe.marchiori@igi.cnr.it [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Finotti, C. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Kudlacek, O. [Università di Padova, Padova (Italy); Villone, F. [Dipartimento di Ingegneria Elettrica e dell’Informazione (DIEI), Università di Cassino (Italy); Zanca, P. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Abate, D. [Dipartimento di Ingegneria Elettrica e dell’Informazione (DIEI), Università di Cassino (Italy); Cavazzana, R. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy); Jackson, G.L.; Luce, T.C. [General Atomics, San Diego, CA (United States); Marrelli, L. [Consorzio RFX, Corso Stati Uniti 4, 35127 Padova (Italy)

2016-10-15

Highlights: • Linearized plasma response model of RFX-mod Tokamak Double/Single Null discharges. • Model based design of a vertical stability control system. • Model based design of a plasma shape LQG control system with Kalman state estimator. • Real time plasma boundary reconstruction algorithm. • Tracking and disturbance rejection experimental tests. - Abstract: The aim of executing Single Null discharges in RFX-mod operating as a Tokamak led to the design and implementation of a plasma shape feedback control system. A fully model-based approach was followed which allowed dealing with critical issues such as the presence of a conducting shell, the strong coupling of the poloidal field coils and the voltage limits of the power supplies. A Linear Quadratic regulator and a Kalman state estimator were designed and implemented in the real time MARTe framework together with an algorithm for the real-time plasma boundary reconstruction. The problem of a number of sensors along the poloidal direction adequate only for circular discharges was also successfully tackled. The development of the system and its performances in terms of tracking and disturbance rejection capability are presented in the paper.

The measurement of the intrinsic impurities of molybdenum and carbon in the Alcator C-Mod tokamak plasma using low resolution spectroscopy

Science.gov (United States)

May, M. J.; Finkenthal, M.; Regan, S. P.; Moos, H. W.; Terry, J. L.; Goetz, J. A.; Graf, M. A.; Rice, J. E.; Marmar, E. S.; Fournier, K. B.; Goldstein, W. H.

1997-06-01

The intrinsic impurity content of molybdenum and carbon was measured in the Alcator C-Mod tokamak using low resolution, multilayer mirror (MLM) spectroscopy ( Delta lambda ~1-10 AA). Molybdenum was the dominant high-Z impurity and originated from the molybdenum armour tiles covering all of the plasma facing surfaces (including the inner column, the poloidal divertor plates and the ion cyclotron resonant frequency (ICRF) limiter) at Alcator C-Mod. Despite the all metal first wall, a carbon concentration of 1 to 2% existed in the plasma and was the major low-Z impurity in Alcator C-Mod. Thus, the behaviour of intrinsic molybdenum and carbon penetrating into the main plasma and the effect on the plasma must be measured and characterized during various modes of Alcator C-Mod operation. To this end, soft X-ray extreme ultraviolet (XUV) emission lines of charge states, ranging from hydrogen-like to helium-like lines of carbon (radius/minor radius, r/a~1) at the plasma edge to potassium to chlorine-like (0.4Data Nucl. Data Tables 33 (1985) 149), which were incorporated into the collisional radiative model. The intrinsic i

A highly scalable peptide-based assay system for proteomics.

Directory of Open Access Journals (Sweden)

Igor A Kozlov

Full Text Available We report a scalable and cost-effective technology for generating and screening high-complexity customizable peptide sets. The peptides are made as peptide-cDNA fusions by in vitro transcription/translation from pools of DNA templates generated by microarray-based synthesis. This approach enables large custom sets of peptides to be designed in silico, manufactured cost-effectively in parallel, and assayed efficiently in a multiplexed fashion. The utility of our peptide-cDNA fusion pools was demonstrated in two activity-based assays designed to discover protease and kinase substrates. In the protease assay, cleaved peptide substrates were separated from uncleaved and identified by digital sequencing of their cognate cDNAs. We screened the 3,011 amino acid HCV proteome for susceptibility to cleavage by the HCV NS3/4A protease and identified all 3 known trans cleavage sites with high specificity. In the kinase assay, peptide substrates phosphorylated by tyrosine kinases were captured and identified by sequencing of their cDNAs. We screened a pool of 3,243 peptides against Abl kinase and showed that phosphorylation events detected were specific and consistent with the known substrate preferences of Abl kinase. Our approach is scalable and adaptable to other protein-based assays.

Modélisation et simulation à base d'agents exemples commentés, outils informatiques et questions théoriques

CERN Document Server

Treuil, Jean-Pierre; Zucker, Jean-Daniel

2008-01-01

Cet ouvrage s'adresse aux étudiants de master des universités et aux élèves des écoles d'ingénieurs ainsi qu'aux mathématiciens, informaticiens et chercheurs de diverses disciplines qui sont amenés à créer des modèles dans leur domaine. La modélisation informatique à base d'agents permet de modéliser, à l'échelle macroscopique, des systèmes complexes à partir du comportement à l'échelle microscopique d'un grand nombre de leurs composants. L'objectif de ce livre se décline en cinq points complémentaires : Présenter au lecteur un panorama des approches de modélisation et simulation à base d'agents sous la forme de 11 exemples représentatifs puisés dans différents domaines scientifiques et technologiques. Proposer un cadre commun de définitions et une ébauche de démarche de conception qui permettent de fournir, au-delà de leur diversité apparente, une base sinon théorique du moins pratique de ces approches. Présenter les outils informatiques existants pour concevoir, spécifier...

Dynamic insecticide susceptibility changes in Florida populations of Diaphorina citri (Hemiptera: Psyllidae).

Science.gov (United States)

Tiwari, Siddharth; Killiny, Nabil; Stelinski, Lukasz L

2013-02-01

Five field populations of Diaphorina citri Kuwayama from various regions of Florida were evaluated in 2011 for resistance to commonly used insecticides. Three diagnostic doses (LD50, LD75, and LD95), developed in 2009 using a laboratory susceptible population, were used to measure changes in susceptibility levels of field-collected populations as compared with a susceptible laboratory population. Further reductions in the susceptibility levels of D. citri to chlorpyriphos and fenpropathrin were determined, compared with results obtained in 2010. Mean percent mortality obtained from all five locations was significantly lower than observed with the laboratory susceptible population for all insecticides tested. Previously, expression of five CYP4 genes was implicated in contributing to insecticide metabolism in D. citri. In the current study, we compared the relative expression of these five CYP4 genes and their associated levels of protein expression among field-collected and laboratory susceptible populations. Expression of all CYP4 genes investigated was higher in field-collected populations when normalized against the laboratory susceptible population. There was an increased signal of a band corresponding to a 45 kDa protein in four of the five field populations as measured by the Western blot assay, which suggests increased production of cytochrome P450 enzymes. The current results indicate that insecticide resistance continues to increase in Florida populations ofD. citri, particularly to chlorpyriphos and fenpropathrin. However, there was no further decrease in susceptibility of Florida populations of D. citri to neonicotinoid insecticides in 2011 as compared with previous years.

Application of Oral Fluid Assays in Support of Mumps, Rubella and Varicella Control Programs

Directory of Open Access Journals (Sweden)

Peter A. C. Maple

2015-12-01

Full Text Available Detection of specific viral antibody or nucleic acid produced by infection or immunization, using oral fluid samples, offers increased potential for wider population uptake compared to blood sampling. This methodology is well established for the control of HIV and measles infections, but can also be applied to the control of other vaccine preventable infections, and this review describes the application of oral fluid assays in support of mumps, rubella and varicella national immunization programs. In England and Wales individuals with suspected mumps or rubella, based on clinical presentation, can have an oral fluid swab sample taken for case confirmation. Universal varicella immunization of children has led to a drastic reduction of chickenpox in those countries where it is used; however, in England and Wales such a policy has not been instigated. Consequently, in England and Wales most children have had chickenpox by age 10 years; however, small, but significant, numbers of adults remain susceptible. Targeted varicella zoster virus (VZV immunization of susceptible adolescents offers the potential to reduce the pool of susceptible adults and oral fluid determination of VZV immunity in adolescents is a potential means of identifying susceptible individuals in need of VZV vaccination. The main application of oral fluid testing is in those circumstances where blood sampling is deemed not necessary, or is undesirable, and when the documented sensitivity and specificity of the oral fluid assay methodology to be used is considered sufficient for the purpose intended.

Stability of Microturbulent Drift Modes during Internal Transport Barrier Formation in the Alcator C-Mod Radio Frequency Heated H-mode

International Nuclear Information System (INIS)

Redi, M.H.; Fiore, C.L.; Dorland, W.; Mikkelsen, D.R.; Rewoldt, G.; Bonoli, P.T.; Ernst, D.R.; Rice, J.E.; Wukitch, S.J.

2003-01-01

Recent H-mode experiments on Alcator C-Mod [I.H. Hutchinson, et al., Phys. Plasmas 1 (1994) 1511] which exhibit an internal transport barrier (ITB), have been examined with flux tube geometry gyrokinetic simulations, using the massively parallel code GS2 [M. Kotschenreuther, G. Rewoldt, and W.M. Tang, Comput. Phys. Commun. 88 (1995) 128]. The simulations support the picture of ion/electron temperature gradient (ITG/ETG) microturbulence driving high xi/ xe and that suppressed ITG causes reduced particle transport and improved ci on C-Mod. Nonlinear calculations for C-Mod confirm initial linear simulations, which predicted ITG stability in the barrier region just before ITB formation, without invoking E x B shear suppression of turbulence. Nonlinear fluxes are compared to experiment, which both show low heat transport in the ITB and higher transport within and outside of the barrier region

Modèles de gestion des ressources forestières du massif ...

International Development Research Centre (IDRC) Digital Library (Canada)

Expérimentation Participative et Adaptative de Modèles de Gestion des Ressources Forestières dans la Chaine Montagneuse de l'Atlas (Algérie, Maroc, Tunisie) : rapport final (17 mars 2009 au 18 septembre 2012). Download PDF. Reports. Unité de transformation de cire d'abeille (Commune de M'Sara). Download PDF ...

Upgrade of the RFX-mod real time control system

Energy Technology Data Exchange (ETDEWEB)

Manduchi, G., E-mail: gabriele.manduchi@igi.cnr.it [Consorzio RFX, Euratom-ENEA Association, Corso Stati Uniti 4, Padova 35127 (Italy); Barbalace, A.; Luchetta, A.; Soppelsa, A.; Taliercio, C.; Zampiva, E. [Consorzio RFX, Euratom-ENEA Association, Corso Stati Uniti 4, Padova 35127 (Italy)

2012-12-15

Highlights: Black-Right-Pointing-Pointer The paper describes the experience in running the real-time control system of RFX-mod. Black-Right-Pointing-Pointer It proposes a new architecture based multicore technology. Black-Right-Pointing-Pointer It analyzes two different solutions for data acquisition. Black-Right-Pointing-Pointer It discusses the effect of non simultaneous sampling in acquisition. Black-Right-Pointing-Pointer It provides some preliminary performance measurements. - Abstract: The real-time control system of RFX-mod, in operation since 2005, has been successful and has allowed several important achievements in the RFX physics research program. As a consequence of this fact, new control algorithms are under investigation, which are more demanding in terms of both enhanced computing power and reduced system latency, currently around 1.5 ms. For this reason, a major upgrade of the system is being considered, and a new architecture has been proposed, taking advantage of the rapid evolution of computer technology in the last years. The central component of the new architecture is a Linux-based multicore server, where individual cores replace the VME computers. The server is connected to the I/O via PCI-e based bus extenders, and every PCI-e connection is managed by a separate core. The system is supervised by MARTe, a software framework for real-time applications written in C++ and developed at JET and currently used for the JET vertical stabilization and in other fusion devices.

Développement d'un modèle ostéoarticulaire du genou humain pour une analyse dynamique du contact en grands déplacements

OpenAIRE

Bideau , Nicolas; Dao , T.T.; Rassineux , Alain; Ho Ba Tho , Marie-Christine

2011-01-01

National audience; Le principal objectif de ce travail est le développement d'un modèle tridimensionnel de l'articulation du genou en grands déplacements. A partir des données d'imagerie médicale (IRM), un modèle géométrique 3D a été développé. Ce modèle est résolu par la méthode des éléments finis. La simulation proposée permet de comprendre le comportement dynamique des différentes structures articulaires lors d'un mouvement de grande amplitude.

MOD-0A 200 kW wind turbine generator design and analysis report

Science.gov (United States)

Anderson, T. S.; Bodenschatz, C. A.; Eggers, A. G.; Hughes, P. S.; Lampe, R. F.; Lipner, M. H.; Schornhorst, J. R.

1980-01-01

The design, analysis, and initial performance of the MOD-OA 200 kW wind turbine generator at Clayton, NM is documented. The MOD-OA was designed and built to obtain operation and performance data and experience in utility environments. The project requirements, approach, system description, design requirements, design, analysis, system tests, installation, safety considerations, failure modes and effects analysis, data acquisition, and initial performance for the wind turbine are discussed. The design and analysis of the rotor, drive train, nacelle equipment, yaw drive mechanism and brake, tower, foundation, electricl system, and control systems are presented. The rotor includes the blades, hub, and pitch change mechanism. The drive train includes the low speed shaft, speed increaser, high speed shaft, and rotor brake. The electrical system includes the generator, switchgear, transformer, and utility connection. The control systems are the blade pitch, yaw, and generator control, and the safety system. Manual, automatic, and remote control are discussed. Systems analyses on dynamic loads and fatigue are presented.

ModSAF-based development of operational requirements for light armored vehicles

Science.gov (United States)

Rapanotti, John; Palmarini, Marc

2003-09-01

Light Armoured Vehicles (LAVs) are being developed to meet the modern requirements of rapid deployment and operations other than war. To achieve these requirements, passive armour is minimized and survivability depends more on sensors, computers, countermeasures and communications to detect and avoid threats. The performance, reliability, and ultimately the cost of these systems, will be determined by the technology trends and the rates at which they mature. Defining vehicle requirements will depend upon an accurate assessment of these trends over a longer term than was previously needed. Modelling and simulation are being developed to study these long-term trends and how they contribute to establishing vehicle requirements. ModSAF is being developed for research and development, in addition to the original requirement of Simulation and Modelling for Acquisition, Rehearsal, Requirements and Training (SMARRT), and is becoming useful as a means for transferring technology to other users, researchers and contractors. This procedure eliminates the need to construct ad hoc models and databases. The integration of various technologies into a Defensive Aids Suite (DAS) can be designed and analyzed by combining field trials and laboratory data with modelling and simulation. ModSAF (Modular Semi-Automated Forces,) is used to construct the virtual battlefield and, through scripted input files, a "fixed battle" approach is used to define and implement contributions from three different sources. These contributions include: models of technology and natural phenomena from scientists and engineers, tactics and doctrine from the military and detailed analyses from operations research. This approach ensures the modelling of processes known to be important regardless of the level of information available about the system. Survivability of DAS-equipped vehicles based on future and foreign technology can be investigated by ModSAF and assessed relative to a test vehicle. A vehicle can

Assessment of TRAC-PF1/MOD3 Mark-22 assembly model using SRL ''A'' tank single-assembly flow experiments

International Nuclear Information System (INIS)

Fischer, S.R.; Lam, K.; Lin, J.C.

1991-01-01

This paper summarizes the results of an assessment of our TRAC-PF1/MOD3 Mark-22 prototype fuel assembly model against single-assembly data obtained from the ''A'' Tank single-assembly tests that were performed at the Savannah River Laboratory. We felt the data characterize prototypic assembly behavior over a range of air-water flow conditions of interest for loss-of-coolant accident (LOCA) calculations. This study was part of a benchmarking effort performed to evaluate and validate a multiple-assembly, full-plant model that is being developed by Los Alamos National Laboratory to study various aspects of the Savannah River plant operating conditions, including LOCA transients, using TRAC-PF1/MOD3 Version 1.10. The results of this benchmarking effort demonstrate that TRAC-PF1/MOD3 is capable pf calculating plenum conditions and assembly flows during conditions thought to be typical of the Emergency Cooling System (ECS) phase of a LOCA. 10 refs., 12 fig

Analyse, Modélisation et Simulation du Mouvement Humain

OpenAIRE

Multon , Franck

2006-01-01

Comprendre le mouvement humain mobilise des chercheurs de nombreuses disciplines scientifiques : physiologie, biomécanique, neurosciences comportementales, anatomie fonctionnelle, les sciences du sport... Mes travaux s'inscrivent donc dans une démarche pluridisciplinaire d'analyse/synthèse du mouvement humain. Pour mener à bien cette démarche, une première tâche consiste à modéliser et à simuler le système moteur ainsi qu'un ensemble d'hypothèses. L'objectif est de disposer d'une représentati...

Blowdown heat transfer surface in RELAP4/MOD6

International Nuclear Information System (INIS)

Nelson, R.A.; Sullivan, L.H.

1978-01-01

New heat transfer correlations for both PWR and BWR blowdowns have been implemented in the RELAP4/MOD6 program. The concept of a multidimensional surface is introduced with the heat flux from a given heat transfer correlation or correlations depicted as a mathematical surface that is dependent upon quality, wall superheat, mass flow and pressure. The heat transfer logic has been modularized to facilitate replacing boiling curves for future correlation data comparisons and investigations. To determine the validity of the blowdown surface, comparison has been performed using data from the Semiscale experimental facility. (author)

Double blind post-test prediction for LOBI-MOD2 small break experiment A2-81 using RELAP5/MOD1/19 computer code as contribution to international CSNI-standardproblem no. 18

International Nuclear Information System (INIS)

Jacobs, G.; Mansoor, S.H.

1986-06-01

The first small break experiment A2-81 performed in the LOBI-MOD2 test facility was the base of the 18th international CSNI standard problem (ISP 18). Taking part in this exercise, a blind post-test prediction was performed using the light water reactor transient analysis code RELAP5/MOD1. This paper describes the input model preparation and summarizes the findings of the pre-calculation comparing the calculational results with the experimental data. The results show that there was a good agreement between prediction and experiment in the initial stage (up to 250 sec) of the transient and an adequate prediction of the global behaviour (thermal response of the core), which is important for safety related considerations. However, the prediction confirmed some deficiencies of the models in the code concerning vertical and horizontal stratification resulting in a high break mass flow and an erroneous distribution of mass over the primary loops. (orig.) [de

Improvement and validation of the wall heat transfer package of RELAP5/MOD3.3

International Nuclear Information System (INIS)

Wu, Pan; Xiong, Xiaofei; Shan, Jianqiang; Gou, Junli; Zhang, Bin; Zhang, Bo

2016-01-01

Highlights: • A new heat transfer package has been developed. • It has been incorporated into RELAP5/MOD3.3 to verify its advantages. • The results of modified code were compared with available experimental data. • The results showed that higher prediction accuracy was achieved. - Abstract: The process of energy transfer from heat structure to control volume is determined by the wall-to-fluid heat transfer package, which is crucial for nuclear reactor safety analysis codes. The current logic for selection of heat transfer modes of RELAP5/MOD3.3 code is too complex and may result in incorrect heat transfer mode judgment. Also, the narrow application scope of film boiling heat transfer correlations may result in large errors in film boiling region which is of paramount importance for the predicted peak clad temperatures during hypothetical LB-LOCAs in PWRs. In this study, a new heat transfer package has been developed and incorporated into the RELAP5/MOD3.3 code. Differing from the original package, the modified one consists of twelve heat transfer modes and proposes a new logic for selection of heat transfer modes. For each mode, the models in the existing safety analysis codes and the leading models in literature have been reviewed in order to determine the best model which can easily be applicable to the RELAP5/MOD3.3 code. Particularly (1) a new package of heat transfer correlations are produced; (2) a new logic for selection of film boiling and transition boiling heat transfer modes is proposed which use minimum film boiling temperature and critical heat flux temperature as distinguished points. The modified code has been validated by comparing the analysis results with available experimental data from tube post dryout experiments and loss-of-fluid test (LOFT) facility. The calculation results showed that the improved package could better predict the experimental phenomena with higher prediction accuracy.

Adjoint sensitivity analysis of the RELAPS/MOD3.2 two-fluid thermal-hydraulic code system

International Nuclear Information System (INIS)

Ionescu-Bujor, M.

2000-10-01

This work presents the implementation of the Adjoint Sensitivity Analysis Procedure (ASAP) for the non-equilibrium, non-homogeneous two-fluid model, including boron concentration and non-condensable gases, of the RELAP5/MOD3.2 code. The end-product of this implementation is the Adjoint Sensitivity Model (ASM-REL/TF), which is derived for both the differential and discretized equations underlying the two-fluid model with non-condensable(s). The consistency requirements between these two representations are also highlighted. The validation of the ASM-REL/TF has been carried out by using sample problems involving: (i) liquid-phase only, (ii) gas-phase only, and (iii) two-phase mixture (of water and steam). Thus the 'Two-Loops with Pumps' sample problem supplied with RELAP5/MOD3.2 has been used to verify the accuracy and stability of the numerical solution of the ASM-REL/TF when only the liquid-phase is present. Furthermore, the 'Edwards Pipe' sample problem, also supplied with RELAP5/MOD3.2, has been used to verify the accuracy and stability of the numerical solution of the ASM-REL/TF when both (i.e., liquid and gas) phases are present. In addition, the accuracy and stability of the numerical solution of the ASM-REL/TF have been verified when only the gas-phase is present by using modified 'Two-Loops with Pumps' and the 'Edwards Pipe' sample problems in which the liquid and two-phase fluids, respectively, were replaced by pure steam. The results obtained for these sample problems depict typical sensitivities of junction velocities and volume-averaged pressures to perturbations in initial conditions, and indicate that the numerical solution of the ASM-REL/TF is as robust, stable, and accurate as the original RELAP5/MOD3.2 calculations. In addition, the solution of the ASM-REL/TF has been used to calculate sample sensitivities of volume-averaged pressures to variations in the pump head. (orig.) [de

Improvement and validation of the wall heat transfer package of RELAP5/MOD3.3

Energy Technology Data Exchange (ETDEWEB)

Wu, Pan; Xiong, Xiaofei; Shan, Jianqiang, E-mail: jqshan@mail.xjtu.edu.cn; Gou, Junli; Zhang, Bin; Zhang, Bo

2016-12-15

Highlights: • A new heat transfer package has been developed. • It has been incorporated into RELAP5/MOD3.3 to verify its advantages. • The results of modified code were compared with available experimental data. • The results showed that higher prediction accuracy was achieved. - Abstract: The process of energy transfer from heat structure to control volume is determined by the wall-to-fluid heat transfer package, which is crucial for nuclear reactor safety analysis codes. The current logic for selection of heat transfer modes of RELAP5/MOD3.3 code is too complex and may result in incorrect heat transfer mode judgment. Also, the narrow application scope of film boiling heat transfer correlations may result in large errors in film boiling region which is of paramount importance for the predicted peak clad temperatures during hypothetical LB-LOCAs in PWRs. In this study, a new heat transfer package has been developed and incorporated into the RELAP5/MOD3.3 code. Differing from the original package, the modified one consists of twelve heat transfer modes and proposes a new logic for selection of heat transfer modes. For each mode, the models in the existing safety analysis codes and the leading models in literature have been reviewed in order to determine the best model which can easily be applicable to the RELAP5/MOD3.3 code. Particularly (1) a new package of heat transfer correlations are produced; (2) a new logic for selection of film boiling and transition boiling heat transfer modes is proposed which use minimum film boiling temperature and critical heat flux temperature as distinguished points. The modified code has been validated by comparing the analysis results with available experimental data from tube post dryout experiments and loss-of-fluid test (LOFT) facility. The calculation results showed that the improved package could better predict the experimental phenomena with higher prediction accuracy.

Scaling criteria and an assessment of Semiscale Mod-3 scaling for small-break loss-of-coolant transients

International Nuclear Information System (INIS)

Larson, T.K.; Anderson, J.L.; Shimeck, D.J.

1982-01-01

Various methods of scaling fluid thermal-hydraulic test facilities and their relative merits and disadvantages are examined in light of nuclear reactor safety considerations. Particular emphasis is placed on examination of the scaling of the Semiscale Mod-3 system and determination of thermal-hydraulic phenomena thought to be important during a small break loss-of-coolant accident in a pressurized water nuclear reactor. The influence of geometric and dynamic scaling concerns in the Mod-3 system on small break behavior are addressed from an engineering viewpoint and corrective measures contemplated or required to make results from Semiscale tests more meaningful relative to expected PWR response are discussed

Modélisation et automatisation des procédés d’écriture et de production de supports de formation numérisés - Le modèle M.A.Ï.HEU.T.I.C. de la CCI de Paris

Directory of Open Access Journals (Sweden)

José Martin

2005-01-01

Full Text Available Cet article expose les conclusions d’un projet de recherche de la Direction de l’Enseignement de la Chambre de Commerce et d’Industrie de Paris (CCIP, mené de 2003 à 2005, dont l’aboutissement est un modèle didactique de production de contenus de cours numérisés, baptisé M.A.Ï.HEU.T.I.C.[[ M.A.Ï.HEU.T.I.C. : Modèle Appliqué d’Interprétation Heuristique des Technologies de l’Information et de la Communication.

Simulation of small break loss of coolant accident using relap 5/ MOD 2 computer code

International Nuclear Information System (INIS)

Megahed, M.M.

1992-01-01

An assessment of relap 5 / MOD 2/Cycle 36.05 best estimate computer code capabilities in predicting the thermohydraulic response of a PWR following a small break loss of coolant accident is presented. The experimental data base for the evaluation is the results of Test S-N H-3 performed in the semi scale MOD-2 c Test facility which modeled a 0.5% small break loss of coolant accident with an accompanying failure of the high pressure injection emergency core cooling system. A conclusion was reached that the code is capable of making small break loss of coolant accident calculations efficiently. However, some of the small break loss of coolant accident related phenomena were not properly predicted by the code, suggesting a need for code improvement.9 fig., 3 tab

Verification of the HDR-test V44 using the computer program RALOC-MOD1/83

International Nuclear Information System (INIS)

Jahn, H.; Pham, T. v.; Weber, G.; Pham, B.T.

1985-01-01

RALOC-MOD1/83 was extended by a drainage and sump level modul and several component models to serve as a containment systems code for various LWR types. One such application is to simulate the blowdown in a full pressure containment which is important for the short and long term hydrogen distribution. The post test calculation of the containment standard problem experiment HDR-V44 shows a good agreement, to the test data. The code may be used for short and long term predictions, but it was learned that double containments need the representation of the gap between the inner and outer shell into several zones to achieve a good long-term temperature prediction. The present work completes the development, verification and documentation of RALOC-MOD1. (orig.) [de

Estimation of pyrazinamidase activity using a cell-free In vitro synthesis of pnca and its association with pyrazinamide susceptibility in Mycobacterium tuberculosis

Directory of Open Access Journals (Sweden)

Daniel Rueda

2018-01-01

Full Text Available Background: The main mechanism of resistance to PZA in Mycobacterium tuberculosis relies on mutations on its pyrazinamidase/nicotinamidase. Recently, a rapid colorimetric test relying on the PCR-based in vitro-synthesized-PZase assay has been reported for PZase activity determination from clinical M. tuberculosis isolates but the assay has not been compared with other tests to evaluate PZA susceptibility in M. tuberculosis isolates. Methods: In this study, we have used the PCR-based in vitro-synthesized-PZase assay to analyze the specific pyrazinamidase (PZase activity of PncA mutants and have correlated the results to the PZA susceptibility phenotype determined by culture in acidic agar medium at pH 6.0. A set of 23 clinical isolates displaying mutated pncA genes (11 PZA-resistant and 12 PZA-susceptible and 55 PZA-susceptible clinical strains displaying a wild-type pncA gene were tested. Results: Among the 23 mutants tested, 4 corresponded to mutations not reported before (I5T, Y99S, T142R and P77L+V131G. Of the 11 PncA mutants expressed from PZA-resistant clinical isolates, 9 were expressed in vitro at yields > 50% relative to the wild type enzyme. Among them, 6 enzymes (T47P, H51P, H51R, H57D, L85R and T142R showed no detectable activity, while the relative activities for the 3 others, V9A (27%, G97D (10% and A146V (28% were low compared to the wild-type PZase. The remaining two mutants, I5T and V9G, presented very low relative expression (5% and relative activities values of 12 and 1%, respectively. Twelve mutants were expressed from PZA-susceptible isolates. Their expression was similar to the wild type enzyme and behaved as active pyrazinamidase with specific relative activities ranging from 34 to 314%. Finally, discrepant results were observed for two mutants, V7A and P62T. Conclusion: Thus, this study provides the proof of concept that the PCR-based in vitro-synthesized-PZase assay represents a promising rapid approach for the evaluation

Estimation of pyrazinamidase activity using a cell-free In vitro synthesis of pnca and its association with pyrazinamide susceptibility in Mycobacterium tuberculosis.

Science.gov (United States)

Rueda, Daniel; Bernard, Christine; Gandy, Lucas; Capton, Estelle; Boudjelloul, Rachid; Brossier, Florence; Veziris, Nicolas; Zimic, Mirko; Sougakoff, Wladimir

2018-01-01

The main mechanism of resistance to PZA in Mycobacterium tuberculosis relies on mutations on its pyrazinamidase/nicotinamidase. Recently, a rapid colorimetric test relying on the PCR-based in vitro-synthesized-PZase assay has been reported for PZase activity determination from clinical M. tuberculosis isolates but the assay has not been compared with other tests to evaluate PZA susceptibility in M. tuberculosis isolates. In this study, we have used the PCR-based in vitro-synthesized-PZase assay to analyze the specific pyrazinamidase (PZase) activity of PncA mutants and have correlated the results to the PZA susceptibility phenotype determined by culture in acidic agar medium at pH 6.0. A set of 23 clinical isolates displaying mutated pncA genes (11 PZA-resistant and 12 PZA-susceptible) and 55 PZA-susceptible clinical strains displaying a wild-type pncA gene were tested. Among the 23 mutants tested, 4 corresponded to mutations not reported before (I5T, Y99S, T142R and P77L+V131G). Of the 11 PncA mutants expressed from PZA-resistant clinical isolates, 9 were expressed in vitro at yields > 50% relative to the wild type enzyme. Among them, 6 enzymes (T47P, H51P, H51R, H57D, L85R and T142R) showed no detectable activity, while the relative activities for the 3 others, V9A (27%), G97D (10%) and A146V (28%) were low compared to the wild-type PZase. The remaining two mutants, I5T and V9G, presented very low relative expression (5%) and relative activities values of 12 and 1%, respectively. Twelve mutants were expressed from PZA-susceptible isolates. Their expression was similar to the wild type enzyme and behaved as active pyrazinamidase with specific relative activities ranging from 34 to 314%. Finally, discrepant results were observed for two mutants, V7A and P62T. Thus, this study provides the proof of concept that the PCR-based in vitro-synthesized-PZase assay represents a promising rapid approach for the evaluation of PZA susceptibility based on the estimation of the

Diagnostic multiplex polymerase chain reaction assay for the identification of Pseudomonas aeruginosa from the skin biopsy specimens in burn wound infections and detection of antibiotic susceptibility

International Nuclear Information System (INIS)

Mashouf, Rasoul Y.; Farahani, Hadi S.; Zamani, A.

2008-01-01

Objective was to identify Pseudomonas aeruginosa (P. aeruginosa) from the skin biopsy specimens in burn wound infections by multiplex polymerase chain reaction (M-PCR) and detection of antimicrobial susceptibility of isolates from culture. We conducted the cross-sectional study in 140 patients with wound infections who admitted to referral burn center of Motahari, Tehran, Iran, during a 12-month period from 2005-2006. Skin biopsy specimens were aseptically taken from each patient, one for PCR and one for bacterial culture. A M-PCR test based on simultaneous amplification of 2 lipoprotein genes: oprI and oprL, was used to directly detect fluorescent pseudomonades and P. aeruginosa in skin biopsy specimens. The susceptibility of P. aeruginosa isolates to 16 antibiotics was determined using the disc diffusion method. Out of 140 biopsy specimens, M-PCR detected 66 (47.2%) isolates, while culture detected 57 (40.7%) isolates as P. aeruginosa. Positive results for both genes which observed only for P. aeruginosa, while only one gene, oprI, was amplified from other fluorescent pseudomonades (n=12) and all other bacterial tested (n=62) were negative by the amplification test. The most effective antibiotics against isolate of P. aeruginosa were cefepime (79%), azetreonam (76%), ticarcillin-clavulanic acid (68%), tobramycin (62%) and amikacin (61%). Multiplex PCR assay appears promising for the rapid and sensitive detection of P. aeruginosa from the burned skin biopsy specimens. Simultaneous amplification of 2 lipoprotein genes: oprI and oprL could detect P. aeruginosa and oprI gene only for other fluorescent pseudomonades. (author)

RELAP/REFLA (Mod 0): a system reflooding analysis computer program

International Nuclear Information System (INIS)

Fujiki, Kazuo; Murao, Yoshio; Shimooke, Takanori.

1981-03-01

A new computer code RELAP/REFLA has been developed, aiming at analyses of the core reflooding phenomena during the postulated loss-of-coolant accident of PWRs. The code was originated from the combination of two distinct codes, RELAP4-FLOOD and REFLA-1D. The characteristics of the code are: (1) Kinematical model based on the observation and analysis of quench experiments is used for the thermal-hydraulic analysis of reflooding core, (2) it has the capability to analyse the reflooding phenomena in an arbitrary type of PWR or experimental facility, including the system feedback effects, (3) the flow paths in the actual system are represented by the combination of 1-dimentional flow paths, and vapor-liquid equilibrium model is applied except the reflooding core. This report is a code manual of RELAP/REFLA (version Mod 0) and contains the descriptions of the basic models, basic equations, code structure and input format. The calculated results of two kinds of sample problems, i.e., reflooding problem on the 4 loop PWR and FLECHT-SET experiment, are also presented. Relatively close agreement between FLECHT-SET data and the calculated results was obtained for the lower portion of the core, but poor agreement for the temperature histories in the upper core and carryover ratio. Running speed and core memory size are almost equal to those of RELAP 4/Mod 3. (author)

Aircraft Survivability. Susceptibility Reduction. Fall 2010

Science.gov (United States)

2010-01-01

the angle and velocity of impact based on wind tunnel testing and ModSim. Test results will provide better insight into the consequences of a...http://www.ndia.org/meetings/1910/Pages/ default.aspx JASP Spring PMSG 29–31 March 2011 TBD

Evaluation of genotype MTBDRplus assay for rapid detection of isoniazid and rifampicin resistance in Mycobacterium tuberculosis clinical isolates from Pakistan

Directory of Open Access Journals (Sweden)

Hasnain Javed

2016-01-01

Conclusions: As evidenced in this study, the major concern with the GenoType MTBDRplus assay were false negative results. In comparison to conventional drug susceptibility testing, the assay was unable to detect 30 (30/100; 30% strains resistant to INH and 23 (23/100; 23% strains resistant to RMP. The GenoType MTBDRplus failed to identify 38 MDR (38/100; 38% strains. Resistance in those strains probably originate from mutations in other codons and/or genes than those covered by the test. For detecting INH and RMP resistance in TB cases, especially in high TB incidence countries, such as Pakistan, molecular approaches should still be a complement rather than areplacement to conventional drug susceptibility testing.

Rapid identification and susceptibility testing of uropathogenic microbes via immunosorbent ATP-bioluminescence assay on a microfluidic simulator for antibiotic therapy.

Science.gov (United States)

Dong, Tao; Zhao, Xinyan

2015-02-17

The incorporation of pathogen identification with antimicrobial susceptibility testing (AST) was implemented on a concept microfluidic simulator, which is well suited for personalizing antibiotic treatment of urinary tract infections (UTIs). The microfluidic device employs a fiberglass membrane sandwiched between two polypropylene components, with capture antibodies immobilized on the membrane. The chambers in the microfluidic device share the same geometric distribution as the wells in a standard 384-well microplate, resulting in compatibility with common microplate readers. Thirteen types of common uropathogenic microbes were selected as the analytes in this study. The microbes can be specifically captured by various capture antibodies and then quantified via an ATP bioluminescence assay (ATP-BLA) either directly or after a variety of follow-up tests, including urine culture, antibiotic treatment, and personalized antibiotic therapy simulation. Owing to the design of the microfluidic device, as well as the antibody specificity and the ATP-BLA sensitivity, the simulator was proven to be able to identify UTI pathogen species in artificial urine samples within 20 min and to reliably and simultaneously verify the antiseptic effects of eight antibiotic drugs within 3-6 h. The measurement range of the device spreads from 1 × 10(3) to 1 × 10(5) cells/mL in urine samples. We envision that the medical simulator might be broadly employed in UTI treatment and could serve as a model for the diagnosis and treatment of other diseases.

Installation and validation of RELAP4/MOD6 on the VAX 11/780 computer at IKE

International Nuclear Information System (INIS)

Lang, U.; Haussmann, C.

1983-06-01

RELAP4/MOD6 is a FORTRAN 4 code for the transient thermohydraulic analysis of nuclear reactors and similar systems. This code has been developed by the Idaho National Engeneering Laboratory for CDC and IBM computers. The implementation of the code on a VAX 11/780 has been possible due to the fact, that this computer is a byte oriented system as the IBM machines, and that the code has been wirtten only in part in a machine dependent way. Two versions of RELAP4/MOD6 are available on the VAX-system, with different dimensions for the input parameters (SI-units or BTU-units). The implementation of the two versions and their validation is described in this report. (orig.) [de

Validation of the RALOC-mod.4 thermal-hydraulics code on evaporation transients in the Phebus containment

International Nuclear Information System (INIS)

Spitz, P.B.; Lemoine, F.; Tirini, S.

1997-01-01

IPSN (Nuclear Protection and Safety Institute) and GRS (Gesellschaft fur Anlagen und Reaktorsicherheit Schwertnergasse 1) are developing the ESCADRE-ASTEC systems of codes devoted to the prediction of the behaviour of water-cooled reactors during a severe accident. The RALOC-mod 4 code belongs to this system and is specifically devoted to containment thermal-hydraulics studies. IPSN has designed a Thermal Hydraulic Containment Test Program in support to the Phebus Fission Product Test Program/2/. Evaporation tests have been recently performed in the Phebus containment test facility. The objective of this work is to assess against these tests the capability of the RALOC -mod 4 code to capture the phenomena observed in these experiments and more particularly the evaporation heat transfer and wall heat transfers. (DM)

Assessment of RELAP5/Mod3 system thermal hydraulic code using power test data of a BWR6 reactor

International Nuclear Information System (INIS)

Lee, M.; Chiang, C.S.

1997-01-01

The power test data of Kuosheng Nuclear Power Plant were used to assess RELAP5/Mod3 system thermal hydraulic analysis code. The plant employed a General Electric designed Boiling Water Reactor (BWR6) with rated power of 2894 MWth. The purpose of the assessment is to verify the validity of the plant specific RELAP5/Mod3 input deck for transient analysis. The power tests considered in the assessment were 100% power generator load rejection, the closure of main steam isolation valves (MSIVs) at 96% power, and the trip of recirculation pumps at 68% power. The major parameters compared in the assessment were steam dome pressure, steam flow rate, core flow rate, and downcomer water level. The comparisons of the system responses predicted by the code and the power test data were reasonable which demonstrated the capabilities of the code and the validity of the input deck. However, it was also identified that the separator model of the code may cause energy imbalance problem in the transient calculation. In the assessment, the steam separators were modeled using time-dependent junctions. In the approach, a complete separation of steam and water was predicted. The system responses predicted by RELAP5/Mod3 code were also compared with those from the calculations of RETRAN code. When these results were compared with the power test data, the predictions of the RETRAN code were better than those of RELAP5/Mod3. In the simulation of 100% power generator load rejection, it was believed that the difference in the steam separator model of these two codes was one of the reason of the difference in the prediction of power test data. The predictions of RELAP/Mod3 code can also be improved by the incorporation of one-dimensional kinetic model. There was also some margin for the improvement of the input related to the feedwater control system. (author)

RELAP5/MOD3 analysis of a heated channel in downflow

International Nuclear Information System (INIS)

Dimenna, R.A.; Qureshi, Z.H.; Boman, A.L.

1993-01-01

The onset of flow instability (OFI) is a significant phenomenon affecting the determination of a safe operating power limit in the Savannah River Site production reactors. Tests performed at Columbia University for a single tube with uniform axial and azimuthal heating have been analyzed with RELAP5/NPR, Version 0, a version of RELAP5/MOD3. The tests include water flow rates from 3.2 x l0 -4 - 2.l x 10 -3 m 3 /s (5 - 33 gpm), Reynolds numbers from 30,000 - 400,000, and surface heat fluxes from 0 - 3.2 x l0 6 w/m 2 (0 - 1,000,000 Btu/hr- ft 2 ). Pressure drop versus flow rate curves were mapped for both fixed pressure boundary conditions and fixed flow boundary conditions. RELAP5/MOD3 results showed fair agreement with data for both types of boundary conditions, and good internal consistency between calculations using the two different types of boundary conditions. Under single-phase unheated conditions, the code overpredicted the pressure drop by 22 - 34%. Under single-phase heated conditions, the overprediction increased to as much as 55%. For those tests where two-phase conditions were observed at the channel exit, RELAP5 predicted lower flows than seen in the tests before voiding occurred

ANTIFUNGAL SUSCEPTIBILITY TESTING: CURRENT ROLE FROM THE CLINICAL LABORATORY PERSPECTIVE

Directory of Open Access Journals (Sweden)

Brunella Posteraro

2014-04-01

Full Text Available Despite availability of many antifungal agents, antifungal clinical resistance occurs, perhaps as a result of an infecting organism found to be resistant in vitro to one or more antifungals tested. Thus, antifungal susceptibility testing (AFST results, if timely generated by the clinical microbiology and communicated to clinicians, can aid them in the therapeutic decision making, especially for difficult-to-treat invasive candidiasis and aspergillosis. Although recently refined AFST methods are commercially available to allow a close antifungal resistance surveillance in many clinical setting, novel assays, relying on short-time antifungal drug exposure of fungal isolates, are upcoming tools for AFST. Based on emerging technologies such as flow cytometry, MALDI-TOF mass spectrometry, and isothermal microcalorimetry, these assays could provide a reliable means for quicker and sensitive assessment of AFST.

A specific interdomain interaction preserves the structural and binding properties of the ModA protein from the phytopathogen Xanthomonas citri domain interaction and transport in ModA.

Science.gov (United States)

Santacruz-Perez, Carolina; Pegos, Vanessa Rodrigues; Honorato, Rodrigo V; Verli, Hugo; Lindahl, Erik; Barbosa, João Alexandre Ribeiro Gonçalves; Balan, Andrea

2013-11-01

The periplasmic-binding proteins in ATP-binding cassette systems (ABC Transporters) are responsible for the capture and delivery of ligands to their specific transporters, triggering a series of ATP-driven conformational changes that leads to the transport of the ligand. Structurally consisting of two lobes, the proteins change conformation after interaction with the ligand. The structure of the molybdate-binding protein (ModA) from Xanthomonas citri, bound to molybdate, was previously solved by our group and an interdomain interaction, mediated by a salt bridge between K127 and D59, apparently supports the binding properties and keeps the domains closed. To determinate the importance of this interaction, we built two ModA mutants, K127S and D59A, and analysed their functional and structural properties. Based on a set of spectroscopic experiments, crystallisation trials, structure determination and molecular dynamics (MD) simulations, we showed that the salt bridge is essential to maintain the structure and binding properties. Additionally, the MD simulations revealed that this mutant adopted a more compact structure that packed down the ligand-binding pocket. From the closed bound to open structure, the positioning of the helices forming the dipole and the salt bridge are essential to induce an intermediate state. Copyright © 2013 Elsevier Inc. All rights reserved.

BEACON/MOD: a computer program for thermal-hydraulic analysis of nuclear reactor containments - user's manual

International Nuclear Information System (INIS)

Broadus, C.R.; Doyle, R.J.; James, S.W.; Lime, J.F.; Mings, W.J.

1980-04-01

The BEACON code is a best-estimate, advanced containment code designed to perform a best-estimate analysis of the flow of a mixture of air, water, and steam in a nuclear reactor containment system under loss-of-coolant accident conditions. The code can simulate two-component, two-phase fluid flow in complex geometries using a combination of two-dimensional, one-dimensional, and lumped-parameter representations for the various parts of the system. The current version of BEACON, which is designated BEACON/MOD3, contains mass and heat transfer models for wall film and wall conduction. It is suitable for the evaluation of short-term transients in dry-containment systems. This manual describes the models employed in BEACON/MOD3 and specifies code implementation requirements. It provides application information for input data preparation and for output data interpretation

Edge Turbulence Imaging on NSTX and Alcator C-Mod

International Nuclear Information System (INIS)

S.J. Zweben; R.A. Maqueda; J.L. Terry; B. Bai; C.J. Boswell; C.E. Bush; D. D'Ippolito; E.D. Fredrickson; M. Greenwald; K. Hallatschek; S. Kaye; B. LaBombard; R. Maingi; J. Myra; W.M. Nevins; B.N. Rogers; D.P. Stotler; J. Wilgen; and X.Q. Xu

2002-01-01

Edge turbulence images have been made using an ultra-high speed CCD camera on both NSTX and Alcator C-Mod. In both cases, the D-alpha or HeI (587.6 nm) line emission from localized deuterium or helium gas puffs was viewed along a local magnetic field line near the outer midplane. Fluctuations in this line emission reflect fluctuations in electron density and/or electron temperature through the atomic excitation rates, which can be modeled using the DEGAS-2 code. The 2-D structure of the measured turbulence can be compared with theoretical simulations based on 3-D fluid models

Modèles aléatoires en écologie et évolution

CERN Document Server

Méléard, Sylvie

2016-01-01

Le but du livre est de définir et développer une grande gamme d'outils probabilistes pour la modélisation en biologie des populations, afin de décrire des dynamiques temporelles de quantités biologiques telles que la taille d'une ou plusieurs populations, la proportion d'un allèle dans une population ou la position d'un individu. En partant de modèles markoviens discrets (marches aléatoires, processus de Galton-Watson), nous abordons progressivement le calcul stochastique et les équations différentielles stochastiques, puis les processus markoviens de saut, tels les processus de branchement à temps continu et les processus de naissance et mort. Nous étudions également les processus discret et continu pour l'évolution génétique et les généalogies: processus de Wright-Fisher et coalescent. Le livre détaille systématiquement les calculs de quantités d'intérêt pour les biologistes. De nombreux exercices d'application sont proposés. Le dernier chapitre montre l'apport de ces outils pour des...

Assessment of RELAP5/MOD3.3 condensation models for the tube bundle condensation in the PCCS of ESBWR

International Nuclear Information System (INIS)

Zhou, W.; Wolf, B.; Revankar, S.T.

2011-01-01

The passive containment condenser system (PCCS) in an ESBWR reactor consists of vertical tube bundle submerged in a large pool of water. The condensation model for the PCCS in a thermalhydraulics code RELAP5/MOD3.3 consists of the default Nusselt model and an alternate condensation model from UCB condensation correlation. An assessment of the PCCS condensation model in RELAP5/MOD3.3 was carried out using experiments conducted on a single tube and tube bundle PCCS tests at Purdue University. The experimental conditions were simulated with the default and the alternate condensation models in the REALP5/MOD3.3 beta version of the code. The default model and the UCB model (alternate model) give quite different results on condensation heat transfer for the PCCS. The default model predicts complete condensation well whereas the UCB model predicts the through flow condensation well. Based on this study it was found that none of the models in REALP5 can predict complete condensation as well as the through flow condensation well. (author)

Assessment of RELAP5/MOD3.3 condensation models for the tube bundle condensation in the PCCS of ESBWR

Energy Technology Data Exchange (ETDEWEB)

Zhou, W., E-mail: wenzzhou@cityu.edu.hk [Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong (China); Wolf, B. [Purdue University, West Lafayette, IN 47907 (United States); Revankar, S. [Purdue University, West Lafayette, IN 47907 (United States); POSTECH, Pohang (Korea, Republic of)

2013-11-15

The passive containment condenser system (PCCS) in an ESBWR reactor consists of vertical tube bundle submerged in a large pool of water. The condensation model for the PCCS in a thermalhydraulics code RELAP5/MOD3.3 consists of the default Nusselt model and an alternate condensation model from UCB condensation correlation. An assessment of the PCCS condensation model in RELAP5/MOD3.3 was carried out using experiments conducted on a single tube and tube bundle PCCS tests at Purdue University. The experimental conditions were simulated with the default and the alternate condensation models in the REALP5/MOD3.3 beta version of the code. The default model and the UCB model (alternate model) give quite different results on condensation heat transfer for the PCCS. The default model predicts complete condensation well whereas the UCB model predicts the through flow condensation well. Based on this study it was found that none of the models in REALP5 can predict complete condensation as well as the through flow condensation well.

Rapid detection of multidrug-resistant Mycobacterium tuberculosis using the malachite green decolourisation assay

Science.gov (United States)

Coban, Ahmet Yilmaz; Uzun, Meltem

2013-01-01

Early detection of drug resistance in Mycobacterium tuberculosis isolates allows for earlier and more effective treatment of patients. The aim of this study was to investigate the performance of the malachite green decolourisation assay (MGDA) in detecting isoniazid (INH) and rifampicin (RIF) resistance in M. tuberculosis clinical isolates. Fifty M. tuberculosis isolates, including 19 multidrug-resistant, eight INH-resistant and 23 INH and RIF-susceptible samples, were tested. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and agreement of the assay for INH were 92.5%, 91.3%, 92.5%, 91.3% and 92%, respectively. Similarly, the sensitivity, specificity, PPV, NPV and agreement of the assay for RIF were 94.7%, 100%, 100%, 96.8% and 98%, respectively. There was a major discrepancy in the tests of two isolates, as they were sensitive to INH by the MGDA test, but resistant by the reference method. There was a minor discrepancy in the tests of two additional isolates, as they were sensitive to INH by the reference method, but resistant by the MGDA test. The drug susceptibility test results were obtained within eight-nine days. In conclusion, the MGDA test is a reliable and accurate method for the rapid detection of INH and RIF resistance compared with the reference method and the MGDA test additionally requires less time to obtain results. PMID:24402143

Rapid detection of multidrug-resistant Mycobacterium tuberculosis using the malachite green decolourisation assay

Directory of Open Access Journals (Sweden)

Ahmet Yilmaz Coban

2013-12-01

Full Text Available Early detection of drug resistance in Mycobacterium tuberculosis isolates allows for earlier and more effective treatment of patients. The aim of this study was to investigate the performance of the malachite green decolourisation assay (MGDA in detecting isoniazid (INH and rifampicin (RIF resistance in M. tuberculosis clinical isolates. Fifty M. tuberculosis isolates, including 19 multidrug-resistant, eight INH-resistant and 23 INH and RIF-susceptible samples, were tested. The sensitivity, specificity, positive predictive value (PPV, negative predictive value (NPV and agreement of the assay for INH were 92.5%, 91.3%, 92.5%, 91.3% and 92%, respectively. Similarly, the sensitivity, specificity, PPV, NPV and agreement of the assay for RIF were 94.7%, 100%, 100%, 96.8% and 98%, respectively. There was a major discrepancy in the tests of two isolates, as they were sensitive to INH by the MGDA test, but resistant by the reference method. There was a minor discrepancy in the tests of two additional isolates, as they were sensitive to INH by the reference method, but resistant by the MGDA test. The drug susceptibility test results were obtained within eight-nine days. In conclusion, the MGDA test is a reliable and accurate method for the rapid detection of INH and RIF resistance compared with the reference method and the MGDA test additionally requires less time to obtain results.

Combustion Modeling with the G-Equation Modélisation de la combustion avec l'équation de G

Directory of Open Access Journals (Sweden)

Peters N.

2006-12-01

Full Text Available Numerical investigations concerning the turbulent flame front propagation in Gasoline Direct Injection (GDI engines were made by implementing a flamelet model in the CFD code Fire. The advantage of this combustion model is the decoupling of the chemistry from the turbulent flow. For this purpose the combustion chamber has to be divided into a burned and an unburned area, which is realized by transporting a scalar field (G-Equation. The reference value defines the present averaged flame position. The complete reaction kinetics is calculated interactively with the CFD code in a one dimensional Representative Interactive Flamelet (RIF code. This combustion model was verified by simulating a 2. 0 l-2 V gasoline engine with homogeneous combustion where a parameter study was conducted to check the flamelet model for plausibility. Finally, the potential of this combustion model was investigated by simulating a hypothetical 2. 0 1-4 V GDI engine. Une investigation numérique relative à la propagation des fronts de flammes turbulents dans les moteurs à essence à injection directe (GDI a été menée en implantant un modèle de flameletdans le code 3D Fire. L'avantage de ce modèle de combustion est de découpler la chimie de l'écoulement turbulent en divisant la chambre de combustion en deux zones : brûlée et imbrûlée, à l'aide d'une équation de transport d'un scalaire (équation de G. Une valeur de référence de ce scalaire définit la position moyenne de la flamme. Une chimie complète est calculée interactivement avec le calcul 3D à l'aide d'un code monodimensionnel RIF (Representative Interactive Flamelet. Le modèle de combustion a été validé sur la simulation d'un moteur 2 litres à 2 soupapes en combustion homogène pour vérifier la représentativité de l'approche flamelet . Puis, le potentiel du modèle de combustion a été étudié en simulant un moteur modèle 2 litres 4 soupapes GDI.

Validation of TGLF in C-Mod and DIII-D using machine learning and integrated modeling tools

Science.gov (United States)

Rodriguez-Fernandez, P.; White, Ae; Cao, Nm; Creely, Aj; Greenwald, Mj; Grierson, Ba; Howard, Nt; Meneghini, O.; Petty, Cc; Rice, Je; Sciortino, F.; Yuan, X.

2017-10-01

Predictive models for steady-state and perturbative transport are necessary to support burning plasma operations. A combination of machine learning algorithms and integrated modeling tools is used to validate TGLF in C-Mod and DIII-D. First, a new code suite, VITALS, is used to compare SAT1 and SAT0 models in C-Mod. VITALS exploits machine learning and optimization algorithms for the validation of transport codes. Unlike SAT0, the SAT1 saturation rule contains a model to capture cross-scale turbulence coupling. Results show that SAT1 agrees better with experiments, further confirming that multi-scale effects are needed to model heat transport in C-Mod L-modes. VITALS will next be used to analyze past data from DIII-D: L-mode ``Shortfall'' plasma and ECH swing experiments. A second code suite, PRIMA, allows for integrated modeling of the plasma response to Laser Blow-Off cold pulses. Preliminary results show that SAT1 qualitatively reproduces the propagation of cold pulses after LBO injections and SAT0 does not, indicating that cross-scale coupling effects play a role in the plasma response. PRIMA will be used to ``predict-first'' cold pulse experiments using the new LBO system at DIII-D, and analyze existing ECH heat pulse data. Work supported by DE-FC02-99ER54512, DE-FC02-04ER54698.

La modélisation mathématique éclaire les politiques de prévention ...

International Development Research Centre (IDRC) Digital Library (Canada)

27 avr. 2016 ... Un projet de recherche financé par le CRDI utilise la modélisation mathématique pour influer sur les politiques locales et nationales de réduction de la transmission du VIH en Chine.

Serial evaluation of the MODS, SOFA and LOD scores to predict ICU mortality in mixed critically ill patients.

Science.gov (United States)

Khwannimit, Bodin

2008-09-01

To perform a serial assessment and compare ability in predicting the intensive care unit (ICU) mortality of the multiple organ dysfunction score (MODS), sequential organ failure assessment (SOFA) and logistic organ dysfunction (LOD) score. The data were collected prospectively on consecutive ICU admissions over a 24-month period at a tertiary referral university hospital. The MODS, SOFA, and LOD scores were calculated on initial and repeated every 24 hrs. Two thousand fifty four patients were enrolled in the present study. The maximum and delta-scores of all the organ dysfunction scores correlated with ICU mortality. The maximum score of all models had better ability for predicting ICU mortality than initial or delta score. The areas under the receiver operating characteristic curve (AUC) for maximum scores was 0.892 for the MODS, 0.907 for the SOFA, and 0.92for the LOD. No statistical difference existed between all maximum scores and Acute Physiology and Chronic Health Evaluation II (APACHE II) score. Serial assessment of organ dysfunction during the ICU stay is reliable with ICU mortality. The maximum scores is the best discrimination comparable with APACHE II score in predicting ICU mortality.

Flux-driven turbulence GDB simulations of the IWL Alcator C-Mod L-mode edge compared with experiment

Science.gov (United States)

Francisquez, Manaure; Zhu, Ben; Rogers, Barrett

2017-10-01

Prior to predicting confinement regime transitions in tokamaks one may need an accurate description of L-mode profiles and turbulence properties. These features determine the heat-flux width upon which wall integrity depends, a topic of major interest for research aid to ITER. To this end our work uses the GDB model to simulate the Alcator C-Mod edge and contributes support for its use in studying critical edge phenomena in current and future tokamaks. We carried out 3D electromagnetic flux-driven two-fluid turbulence simulations of inner wall limited (IWL) C-Mod shots spanning closed and open flux surfaces. These simulations are compared with gas puff imaging (GPI) and mirror Langmuir probe (MLP) data, examining global features and statistical properties of turbulent dynamics. GDB reproduces important qualitative aspects of the C-Mod edge regarding global density and temperature profiles, within reasonable margins, and though the turbulence statistics of the simulated turbulence follow similar quantitative trends questions remain about the code's difficulty in exactly predicting quantities like the autocorrelation time A proposed breakpoint in the near SOL pressure and the posited separation between drift and ballooning dynamics it represents are examined This work was supported by DOE-SC-0010508. This research used resources of the National Energy Research Scientific Computing Center (NERSC).

Analysis of the General Electric Company swell tests with RELAP4/MOD7

International Nuclear Information System (INIS)

Fischer, S.R.; Hendrix, C.E.

1979-01-01

The RELAP4/MOD7 nuclear reactor transient analysis code, presently being developed by EG and G Idaho, Inc., will incorporate several significant improvements over earlier versions of RELAP4. As part of the development of RELAP4/MOD7, a thorough assessment of the capability of the code to simulate water reactor LOCA phenomena is being made. This assessment is accomplished in part by comparing results from code calculations with test data from experimental facilities. Simulations of the General Electric Company (GE) level swell tests were performed as part of the code checkout. In these tests, a pressurized vessel partially filled with nearly saturated water was blown down through a simulated break located near the top of the vessel. Comparison of RELAP4 calculations with data from these experiments indicates that the code has the capability to model the unequal phase velocity flow and resulting density gradients that might occur in a BWR steam line break transient. Comparisons of RELAP4 calculations with data from two level swell experiments are presented

Comparison and Evaluation of Annual NDVI Time Series in China Derived from the NOAA AVHRR LTDR and Terra MODIS MOD13C1 Products.

Science.gov (United States)

Guo, Xiaoyi; Zhang, Hongyan; Wu, Zhengfang; Zhao, Jianjun; Zhang, Zhengxiang

2017-06-06

Time series of Normalized Difference Vegetation Index (NDVI) derived from multiple satellite sensors are crucial data to study vegetation dynamics. The Land Long Term Data Record Version 4 (LTDR V4) NDVI dataset was recently released at a 0.05 × 0.05° spatial resolution and daily temporal resolution. In this study, annual NDVI time series that are composited by the LTDR V4 and Moderate Resolution Imaging Spectroradiometer (MODIS) NDVI datasets (MOD13C1) are compared and evaluated for the period from 2001 to 2014 in China. The spatial patterns of the NDVI generally match between the LTDR V4 and MOD13C1 datasets. The transitional zone between high and low NDVI values generally matches the boundary of semi-arid and sub-humid regions. A significant and high coefficient of determination is found between the two datasets according to a pixel-based correlation analysis. The spatially averaged NDVI of LTDR V4 is characterized by a much weaker positive regression slope relative to that of the spatially averaged NDVI of the MOD13C1 dataset because of changes in NOAA AVHRR sensors between 2005 and 2006. The measured NDVI values of LTDR V4 were always higher than that of MOD13C1 in western China due to the relatively lower atmospheric water vapor content in western China, and opposite observation appeared in eastern China. In total, 18.54% of the LTDR V4 NDVI pixels exhibit significant trends, whereas 35.79% of the MOD13C1 NDVI pixels show significant trends. Good agreement is observed between the significant trends of the two datasets in the Northeast Plain, Bohai Economic Rim, Loess Plateau, and Yangtze River Delta. By contrast, the datasets contrasted in northwestern desert regions and southern China. A trend analysis of the regression slope values according to the vegetation type shows good agreement between the LTDR V4 and MOD13C1 datasets. This study demonstrates the spatial and temporal consistencies and discrepancies between the AVHRR LTDR and MODIS MOD13C1 NDVI

Overview of Alcator C-Mod Research

Science.gov (United States)

White, A. E.

2017-10-01

Alcator C-Mod, a compact (R =0.68m, a =0.21m), high magnetic field, Bt Research spans the topics of core transport and turbulence, RF heating and current drive, pedestal physics, scrape-off layer, divertor and plasma wall interactions. In the last experimental campaign, Super H-mode was explored and featured the highest pedestal pressures ever recorded, pped 90 kPa (90% of ITER target), consistent with EPED predictions. Optimization of naturally ELM-suppressed EDA H-modes accessed the highest volume averaged pressures ever achieved (〈p〉>2 atm), with pped 60 kPa. The SOL heat flux width has been measured at Bpol = 1.25T, confirming the Eich scaling over a broader poloidal field range than before. Multi-channel transport studies focus on the relationship between momentum transport and heat transport with perturbative experiments and new multi-scale gyrokinetic simulation validation techniques were developed. U.S. Department of Energy Grant No. DE-FC02-99ER54512.

A Unified Model for Slug Flow Generation Modélisation de la formation des bouchons : vers un modèle stochastique unifié

Directory of Open Access Journals (Sweden)

Bernicot M.

2006-11-01

Full Text Available In order to improve the global safety and reliability level of multi-phase production systems and to guarantee their economical efficiency, we need a better understanding and control of hydraulic instabilities observed at the outlet of multi-phase sea-lines. This may be obtained through the development of slug flow stochastic models, which must be able to explain:(a The generation of the various types of slug length distributions which are observed on experimental data sets. (b The evolution of these distributions along the sea-lines up to their outlets, where large hydraulic fluctuations may be dangerous for the treatment installations. Based on experimental as well as theoretical arguments, we present such a model with emphasis on slug generation. We give a detailed theoretical analysis, together with a discussion of the underlying assumptions which justify the introduction of this model. Ce résumé contient des formules (*** qui ne peuvent s'afficher à l'écran. Pour garantir à la fois la sûreté de fonctionnement et la rentabilité des systèmes de production avec transport polyphasique, il est nécessaire de mieux comprendre et maîtriser les phénomènes d'instabilité hydraulique dans les conduites polyphasiques. Ceci suppose la mise au point et l'utilisation de Modèles de Simulation des écoulements portant, non seulement sur l'évolution dans le temps et en tout point de la conduite des valeurs moyennes des diverses variables (cf. le modèle TACITE, mais aussi sur leurs aspects stochastiques en prenant spécialement en compte : - les lois statistiques propres des divers mécanismes fondamentaux de formation des bouchons (distribution des longueurs de bouchons de liquide et de poches de gaz; - l'évolution de ces lois statistiques dans le temps et tout le long de la conduite (et ceci, jusqu'à son extrémité, extrémité dont les caractéristiques intéressent tout spécialement l'opérateur de la conduite. Nous présenterons ici

Bacterial Cytological Profiling (BCP as a Rapid and Accurate Antimicrobial Susceptibility Testing Method for Staphylococcus aureus

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D.T. Quach

2016-02-01

Full Text Available Successful treatment of bacterial infections requires the timely administration of appropriate antimicrobial therapy. The failure to initiate the correct therapy in a timely fashion results in poor clinical outcomes, longer hospital stays, and higher medical costs. Current approaches to antibiotic susceptibility testing of cultured pathogens have key limitations ranging from long run times to dependence on prior knowledge of genetic mechanisms of resistance. We have developed a rapid antimicrobial susceptibility assay for Staphylococcus aureus based on bacterial cytological profiling (BCP, which uses quantitative fluorescence microscopy to measure antibiotic induced changes in cellular architecture. BCP discriminated between methicillin-susceptible (MSSA and -resistant (MRSA clinical isolates of S. aureus (n = 71 within 1–2 h with 100% accuracy. Similarly, BCP correctly distinguished daptomycin susceptible (DS from daptomycin non-susceptible (DNS S. aureus strains (n = 20 within 30 min. Among MRSA isolates, BCP further identified two classes of strains that differ in their susceptibility to specific combinations of beta-lactam antibiotics. BCP provides a rapid and flexible alternative to gene-based susceptibility testing methods for S. aureus, and should be readily adaptable to different antibiotics and bacterial species as new mechanisms of resistance or multidrug-resistant pathogens evolve and appear in mainstream clinical practice.

Assessment of ICARE/CATHARE V1mod1 and V1 applications to full scale studies

International Nuclear Information System (INIS)

Chatelard, P.; Barre, F.; Mutelle, H.

2001-01-01

The objective initially assigned to the ICARE/CATHARE V1mod1 validation task was to draw a synthesis of the ability of the code to correctly reproduce the main physical processes occurring during severe accidents. Therefore, both the domain in which the ICARE/CATHARE V1mod1 predictions are satisfactory (good confidence level) and, conversely, the identification of the main code deficiencies have to be highlighted. After a brief recall of the validation strategy and the current status of the work, this paper summarizes the main lessons which were drawn by IPSN from the validation activity which was conducted during the last two years (in 2000-2001) in the particular framework of the Users' Club (both IPSN and several foreign partners were involved in this task, under the management of IPSN). (authors)

Testing of Software Routine to Determine Deviate and Cumulative Probability: ModStandardNormal Version 1.0

International Nuclear Information System (INIS)

A.H. Monib

1999-01-01

The purpose of this calculation is to document that the software routine ModStandardNomal Version 1.0 which is a Visual Fortran 5.0 module, provides correct results for a normal distribution up to five significant figures (three significant figures at the function tails) for a specified range of input parameters. The software routine may be used for quality affecting work. Two types of output are generated in ModStandardNomal: a deviate, x, given a cumulative probability, p, between 0 and 1; and a cumulative probability, p, given a deviate, x, between -8 and 8. This calculation supports Performance Assessment, under Technical Product Development Plan, TDP-EBS-MD-000006 (Attachment I, DIRS 3) and is written in accordance with the AP-3.12Q Calculations procedure (Attachment I, DIRS 4)

Evaluation of the RELAP5/MOD3 multidimensional component model

International Nuclear Information System (INIS)

Tomlinson, E.T.; Rens, T.E.; Coffield, R.D.

1994-01-01

Accurate plenum predictions, which are directly related to the mixing models used, are an important plant modeling consideration because of the consequential impact on basic transient performance calculations for the integrated system. The effect of plenum is a time shift between inlet and outlet temperature changes to the particular volume. Perfect mixing, where the total volume interacts instantaneously with the total inlet flow, does not occur because of effects such as inlet/outlet nozzle jetting, flow stratification, nested vortices within the volume and the general three-dimensional velocity distribution of the flow field. The time lag which exists between the inlet and outlet flows impacts the predicted rate of temperature change experienced by various plant system components and this impacts local component analyses which are affected by the rate of temperature change. This study includes a comparison of two-dimensional plenum mixing predictions using CFD-FLOW3D, RELAP5/MOD3 and perfect mixing models. Three different geometries (flat, square and tall) are assessed for scalar transport times using a wide range of inlet velocity and isothermal conditions. In addition, the three geometries were evaluated for low flow conditions with the inlet flow experiencing a large step temperature decrease. A major conclusion from this study is that the RELAP5/MOD3 multidimensional component model appears to be adequately predicting plenum mixing for a wide range of thermal-hydraulic conditions representative of plant transients

Production of internal transport barriers via self-generated mean flows in Alcator C-Mod

Energy Technology Data Exchange (ETDEWEB)

Fiore, C. L.; Ernst, D. R.; Podpaly, Y. A.; Howard, N. T.; Lee, Jungpyo; Reinke, M. L.; Rice, J. E.; Hughes, J. W.; Ma, Y. [MIT-PSFC, 77 Mass. Ave., Cambridge, Massachusetts 02139 (United States); Mikkelsen, D. [Princeton Plasma Physics Laboratory, P.O. Box 451, Princeton, New Jersey 08543-0451 (United States); Rowan, W. L.; Bespamyatnov, I. [FRC, U of Texas at Austin, Austin, Texas 78712 (United States)

2012-05-15

New results suggest that changes observed in the intrinsic toroidal rotation influence the internal transport barrier (ITB) formation in the Alcator C-Mod tokamak [E. S. Marmar and Alcator C-Mod group, Fusion Sci. Technol. 51, 261 (2007)]. These arise when the resonance for ion cyclotron range of frequencies (ICRF) minority heating is positioned off-axis at or outside of the plasma half-radius. These ITBs form in a reactor relevant regime, without particle or momentum injection, with Ti Almost-Equal-To Te, and with monotonic q profiles (q{sub min} < 1). C-Mod H-mode plasmas exhibit strong intrinsic co-current rotation that increases with increasing stored energy without external drive. When the resonance position is moved off-axis, the rotation decreases in the center of the plasma resulting in a radial toroidal rotation profile with a central well which deepens and moves farther off-axis when the ICRF resonance location reaches the plasma half-radius. This profile results in strong E Multiplication-Sign B shear (>1.5 Multiplication-Sign 10{sup 5} rad/s) in the region where the ITB foot is observed. Gyrokinetic analyses indicate that this spontaneous shearing rate is comparable to the linear ion temperature gradient (ITG) growth rate at the ITB location and is sufficient to reduce the turbulent particle and energy transport. New and detailed measurement of the ion temperature demonstrates that the radial profile flattens as the ICRF resonance position moves off axis, decreasing the drive for the ITG the instability as well. These results are the first evidence that intrinsic rotation can affect confinement in ITB plasmas.

Le nouveau modèle québécois axé sur la gouvernance

Directory of Open Access Journals (Sweden)

Jeffrey Roy

2002-10-01

Full Text Available L'article soutient qu'il a bien eu un modèle québécois de développement, mais il est devenu inefficace et remis en question. Ce modèle se distinguait par son interventionniste étatique dynamique et par la constitution d'alliances entre les différents partenaires sociaux. Mais les fondements d'un modèle performant tels que l'étatisme et le nationalisme civique sont devenus empreints de faiblesses et d'insuffisances que l'utilisation du concept de gouvernance permet d'identifier. Le concept se définit comme étant « la coordination efficace de l'ensemble des activités d'une entité socio-économico-politique quand les ressources, le pouvoir et l'information sont vastement distribués ». Malgré l'inefficacité décrite, il est possible de repenser le modèle québécois de développement par la construction des communautés qui s'appuie sur la régionalité et la socialité. Finalement, le renouveau s'appuierait sur une stratégie de-gouvernance pour un meilleur usage de l'intelligence collective et des cités-régions intelligentes.The article supports that it indeed had a Quebecois model of development, but it became ineffective and questioned. This model distinguished itself by his(her dynamic state interventionist and by the constitution of alliances among the various social partners. But the foundations of a successful model such as the state control and the civil nationalism became printed by weaknesses and by incapacities which the use of the concept of governance allows to identify. The concept defines itself as being « the effective coordination of all the activities of an entity « socio-économico-politique » when the resources, the power and the information are distributed spaciously » Meanwhile the described ineffectiveness, it is possible to rethink the Quebecois model of development by the construction of the communities which leans on the regionality and the sociality. Finally, the flourish would lean on a strategy

Evaluation of the Roche prototype 454 HIV-1 ultradeep sequencing drug resistance assay in a routine diagnostic laboratory.

Science.gov (United States)

Garcia-Diaz, A; Guerrero-Ramos, A; McCormick, A L; Macartney, M; Conibear, T; Johnson, M A; Haque, T; Webster, D P

2013-10-01

Studies have shown that low-frequency resistance mutations can influence treatment outcome. However, the lack of a standardized high-throughput assay has precluded their detection in clinical settings. To evaluate the performance of the Roche prototype 454 UDS HIV-1 drug resistance assay (UDS assay) in a routine diagnostic laboratory. 50 plasma samples, previously characterized by population sequencing and that had shown ≥1 resistance associated mutation (RAM), were retrospectively tested by the UDS assay, including 18 B and 32 non-B subtypes; viral loads between 114-1,806,407 cp/ml; drug-naive (n=27) and drug-experienced (n=23) individuals. The UDS assay was successful for 37/50 (74%) samples. It detected all RAMs found by population sequencing at frequencies above 20%. In addition, 39 low-frequency RAMs were exclusively detected by the UDS assay at frequencies below 20% in both drug-naïve (19/26, 73%) and drug-experienced (9/18, 50%) individuals. UDS results would lead to changes from susceptible to resistant to efavirenz (EFV) in one drug-naive individual with suboptimal response to an EFV-containing regimen and from susceptible to resistance to lamivudine (3TC) in one drug naïve subject who subsequently failed a 3TC-containing regimen and in a treatment experienced subject who had failed a 3TC-containing regimen. The UDS assay performed well across a wide range of subtypes and viral loads; it showed perfect agreement with population sequencing for all RAMs analyzed. In addition, the UDS assay detected additional mutations at frequencies below 20% which correlate with patients' treatment history and had in some cases important prognostic implications. Copyright © 2013 Elsevier B.V. All rights reserved.

A histidine-rich protein 2-based malaria drug sensitivity assay for field use.

Science.gov (United States)

Noedl, Harald; Attlmayr, Bernhard; Wernsdorfer, Walther H; Kollaritsch, Herwig; Miller, Robert S

2004-12-01

With the spread of antimalarial drug resistance, simple and reliable tools for the assessment of antimalarial drug resistance, particularly in endemic regions and under field conditions, have become more important than ever before. We therefore developed a histidine-rich protein 2 (HRP2)-based drug sensitivity assay for testing of fresh isolates of Plasmodium falciparum in the field. In contrast to the HRP2 laboratory assay, the field assay uses a procedure that further simplifies the handling and culturing of malaria parasites by omitting centrifugation, washing, the use of serum, and dilution with uninfected red blood cells. A total of 40 fresh Plasmodium falciparum isolates were successfully tested for their susceptibility to dihydroartemisinin, mefloquine, quinine, and chloroquine (50% inhibitory concentration [IC50] = 3.43, 61.89, 326.75, and 185.31 nM, respectively). Results very closely matched those obtained with a modified World Health Organization schizont maturation assay (R2 = 0.96, P < 0.001; mean log difference at IC50 = 0.054).

Antibiotic susceptibility of periodontal Streptococcus constellatus and Streptococcus intermedius clinical isolates.

Science.gov (United States)

Rams, Thomas E; Feik, Diane; Mortensen, Joel E; Degener, John E; van Winkelhoff, Arie J

2014-12-01

Streptococcus constellatus and Streptococcus intermedius in subgingival dental plaque biofilms may contribute to forms of periodontitis that resist treatment with conventional mechanical root debridement/surgical procedures and may additionally participate in some extraoral infections. Because systemic antibiotics are often used in these clinical situations, and little is known of the antibiotic susceptibility of subgingival isolates of these two bacterial species, this study determined the in vitro susceptibility to six antibiotics of fresh S. constellatus and S. intermedius clinical isolates from human periodontitis lesions. A total of 33 S. constellatus and 17 S. intermedius subgingival strains, each recovered from separate patients with severe chronic periodontitis (n = 50) before treatment, were subjected to antibiotic gradient strip susceptibility testing with amoxicillin, azithromycin, clindamycin, ciprofloxacin, and doxycycline on blood-supplemented Mueller-Hinton agar and to the inhibitory effects of metronidazole at 16 mg/L in an enriched Brucella blood agar dilution assay. Clinical and Laboratory Standards Institute and European Committee on Antimicrobial Susceptibility Testing interpretative standards were used to assess the results. Clindamycin was the most active antibiotic against S. constellatus (minimum inhibitory concentration at 90% [MIC90] 0.25 mg/L), and amoxicillin was most active against S. intermedius (MIC90 0.125 mg/L). A total of 30% of the S. constellatus and S. intermedius clinical isolates were resistant in vitro to doxycycline, 98% were only intermediate in susceptibility to ciprofloxacin, and 90% were resistant to metronidazole at 16 mg/L. Subgingival S. constellatus and S. intermedius exhibited variable antibiotic susceptibility profiles, potentially complicating empirical selection of periodontitis antibiotic therapy in patients who are species positive.

In Vitro Antimicrobial Susceptibility of Pathogenic Leptospira Biofilm.

Science.gov (United States)

Vinod Kumar, Kirubakaran; Lall, Chandan; Raj, Ratchagadasse Vimal; Vedhagiri, Kumaresan; Sunish, Ittoop Pulikkottil; Vijayachari, Paluru

2016-10-01

Pathogenic Leptospira spp. are the causative agent of leptospirosis. Biofilm formation in leptospires is a new area of study, and its role in pathogenesis is not fully explored. As in other biofilm-forming bacteria, Leptospira biofilm may play a significant role in antibiotic resistance. In this study, the antimicrobial susceptibility of Leptospira biofilm was investigated by 96-well plate assay using Alamar Blue. Leptospira biofilm showed five to sixfold increase in resistance in all the strains used. The range of minimal bactericidal concentrations for penicillin G, ampicillin, tetracycline, and doxycycline was 1,600 U/ml, 800-1,600 μg/ml, 800-1,600 μg/ml, and 800-1,600 μg/ml, respectively. In agar substrate, the biofilm showed six- to sevenfold increase in resistance to antibiotics compared to planktonic cell. The present study emphasizes the importance of biofilm formation and its antibiotic susceptibility patterns. This could pave the way for devising appropriate strategy to prevent the occurrence of potential chronic leptospirosis in endemic areas and also during an outbreak situation.

RELAP5/MOD2 models and correlations

International Nuclear Information System (INIS)

Dimenna, R.A.; Larson, J.R.; Johnson, R.W.; Larson, T.K.; Miller, C.S.; Streit, J.E.; Hanson, R.G.; Kiser, D.M.

1988-08-01

A review of the RELAP5/MOD2 computer code has been performed to assess the basis for the models and correlations comprising the code. The review has included verification of the original data base, including thermodynamic, thermal-hydraulic, and geothermal conditions; simplifying assumptions in implementation or application; and accuracy of implementation compared to documented descriptions of each of the models. An effort has been made to provide the reader with an understanding of what is in the code and why it is there and to provide enough information that an analyst can assess the impact of the correlation or model on the ability of the code to represent the physics of a reactor transient. Where assessment of the implemented versions of the models or correlations has been accomplished and published, the assessment results have been included

Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer

Directory of Open Access Journals (Sweden)

Mohammad Habash

2017-10-01

Full Text Available Whilst the near instantaneous physical interaction of radiation energy with living cells leaves little opportunity for inter-individual variation in the initial yield of DNA damage, all the downstream processes in how damage is recognized, repaired or resolved and therefore the ultimate fate of cells can vary across the population. In the clinic, this variability is observed most readily as rare extreme sensitivity to radiotherapy with acute and late tissue toxic reactions. Though some radiosensitivity can be anticipated in individuals with known genetic predispositions manifest through recognizable phenotypes and clinical presentations, others exhibit unexpected radiosensitivity which nevertheless has an underlying genetic cause. Currently, functional assays for cellular radiosensitivity represent a strategy to identify patients with potential radiosensitivity before radiotherapy begins, without needing to discover or evaluate the impact of the precise genetic determinants. Yet, some of the genes responsible for extreme radiosensitivity would also be expected to confer susceptibility to radiation-induced cancer, which can be considered another late adverse event associated with radiotherapy. Here, the utility of functional assays of radiosensitivity for identifying individuals susceptible to radiotherapy-induced second cancer is discussed, considering both the common mechanisms and important differences between stochastic radiation carcinogenesis and the range of deterministic acute and late toxic effects of radiotherapy.

Se servir de la modélisation pour lutter contre les maladies ...

International Development Research Centre (IDRC) Digital Library (Canada)

En se fondant sur des données émanant des activités de recherche et de surveillance du National Center for AIDS/STD Control and Prevention de la Chine, l'équipe de recherche s'emploie à concevoir des modèles propres à certaines maladies, en commençant par l'infection au VIH. Après avoir déterminé les différents ...

High Speed Images of Edge Plasmas in NSTX and Alcator C-Mod

International Nuclear Information System (INIS)

Maqueda, R.J.; Grulke, O.; Terry, J.L.; Zweben, S.J.

2007-01-01

This talk will describe the high speed imaging diagnostics on NSTX and Alcator C-Mod and show movies of various edge phenomena, including turbulence during L-modes and H modes, L-H and H-L transitions, effects of MHD activity and ELMs of various types, and wide angle views of the toroidal vs. poloidal structure of these edge '' filaments ''. Issues concerning the interpretation of these images will be discussed. (author)

TRAC-BDl/MOD1 post-dryout wall heat transfer

International Nuclear Information System (INIS)

Shumway, R.W.

1984-01-01

A comparison of TRAC-BWR heat transfer package with 766 data points is presented. On the average, TRAC-BWR provides a better prediction of the data compared to any single correlation although there is still a large scatter in TRAC-BWR prediction. Regarding any potential changes in the TRAC-BD1/MOD1 wall heat transfer package, it is concluded that no significant improvement in the film boiling area can be made until data with better measurements are obtained and analyzed. Specifically, data is needed which has a wide range of accurately measured void fractions. Heated tube data is also needed which addresses the countercurrent flow transition conditions

Stationary density profiles in the Alcator C-mod tokamak

International Nuclear Information System (INIS)

Kesner, J.; Ernst, D.; Hughes, J.; Mumgaard, R.; Shiraiwa, S.; Whyte, D.; Scott, S.

2012-01-01

In the absence of an internal particle source, plasma turbulence will impose an intrinsic relationship between an inwards pinch and an outwards diffusion resulting in a stationary density profile. The Alcator C-mod tokamak utilizes RF heating and current drive so that fueling only occurs in the vicinity of the separatrix. Discharges that transition from L-mode to I-mode are seen to maintain a self-similar stationary density profile as measured by Thomson scattering. For discharges with negative magnetic shear, an observed rise of the safety factor in the vicinity of the magnetic axis appears to be accompanied by a decrease of electron density, qualitatively consistent with the theoretical expectations.

Utilization of the RELAP4/MOD5/SAS code version in loss of coolant accident in the Angra 1 nuclear power station

International Nuclear Information System (INIS)

Sabundjian, G.; Freitas, R.L.

1991-09-01

A new version of computer code RELAP4/MOD5 was developed to improve the output. The new version, called RELAP4/MOD5/SAS, prints the main variables in graphical form. In order to check the program, a 36 - volume simulation of the Loss-of-Coolant Accident for Angra - I was performed and the results compared to those of a existing 44 - volume simulation showed a satisfactory agreement with a substantial reduction in computing time. (author)

Edge Minority Heating Experiment in Alcator C-Mod

International Nuclear Information System (INIS)

Zweben, S.J.; Terry, J.L.; Bonoli, P.; Budny, R.; Chang, C.S.; Fiore, C.; Schilling, G.; Wukitch, S.; Hughes, J.; Lin, Y.; Perkins, R.; Porkolab, M.; Alcator C-Mod Team

2005-01-01

An attempt was made to control global plasma confinement in the Alcator C-Mod tokamak by applying ion cyclotron resonance heating (ICRH) power to the plasma edge in order to deliberately create a minority ion tail loss. In theory, an edge fast ion loss could modify the edge electric field and so stabilize the edge turbulence, which might then reduce the H-mode power threshold or improve the H-mode barrier. However, the experimental result was that edge minority heating resulted in no improvement in the edge plasma parameters or global stored energy, at least at power levels of P RF (le) 5.5 MW. A preliminary analysis of these results is presented and some ideas for improvement are discussed

Nonequilibrium constitutive models for RELAP5/MOD2

International Nuclear Information System (INIS)

Lin, J.C.; Trapp, J.A.; Riemke, R.A.; Ransom, V.H.

1983-01-01

RELAP5/MOD2 is a new version of RELAP5 containing improved modeling features that provide a generic pressurized-water transient simulation capability. In particular, the nonequilibrium modeling capability has been generalized to include conditions that occur in operational transients including repressurization and emergency-feed-water injection with loss-of-coolant accidents. The improvements include addition of a second energy equation to the hydrodynamic model, addition of nonequilibrium heat-transfer models, and the associated nonequilibrium vapor-generation models. The objective of this paper is to describe these models and to report the developmental assessment results obtained from similar of several separate effects experiments. The assessment shows that RELAP5 calculated results are in good agreement with data and the nonequilibrium phenomena are properly modeled

Susceptibility-Weighted Imaging and Quantitative Susceptibility Mapping in the Brain

Science.gov (United States)

Liu, Chunlei; Li, Wei; Tong, Karen A.; Yeom, Kristen W.; Kuzminski, Samuel

2015-01-01

Susceptibility-weighted imaging (SWI) is a magnetic resonance imaging (MRI) technique that enhances image contrast by using the susceptibility differences between tissues. It is created by combining both magnitude and phase in the gradient echo data. SWI is sensitive to both paramagnetic and diamagnetic substances which generate different phase shift in MRI data. SWI images can be displayed as a minimum intensity projection that provides high resolution delineation of the cerebral venous architecture, a feature that is not available in other MRI techniques. As such, SWI has been widely applied to diagnose various venous abnormalities. SWI is especially sensitive to deoxygenated blood and intracranial mineral deposition and, for that reason, has been applied to image various pathologies including intracranial hemorrhage, traumatic brain injury, stroke, neoplasm, and multiple sclerosis. SWI, however, does not provide quantitative measures of magnetic susceptibility. This limitation is currently being addressed with the development of quantitative susceptibility mapping (QSM) and susceptibility tensor imaging (STI). While QSM treats susceptibility as isotropic, STI treats susceptibility as generally anisotropic characterized by a tensor quantity. This article reviews the basic principles of SWI, its clinical and research applications, the mechanisms governing brain susceptibility properties, and its practical implementation, with a focus on brain imaging. PMID:25270052

Susceptibility-weighted imaging and quantitative susceptibility mapping in the brain.

Science.gov (United States)

Liu, Chunlei; Li, Wei; Tong, Karen A; Yeom, Kristen W; Kuzminski, Samuel

2015-07-01

Susceptibility-weighted imaging (SWI) is a magnetic resonance imaging (MRI) technique that enhances image contrast by using the susceptibility differences between tissues. It is created by combining both magnitude and phase in the gradient echo data. SWI is sensitive to both paramagnetic and diamagnetic substances which generate different phase shift in MRI data. SWI images can be displayed as a minimum intensity projection that provides high resolution delineation of the cerebral venous architecture, a feature that is not available in other MRI techniques. As such, SWI has been widely applied to diagnose various venous abnormalities. SWI is especially sensitive to deoxygenated blood and intracranial mineral deposition and, for that reason, has been applied to image various pathologies including intracranial hemorrhage, traumatic brain injury, stroke, neoplasm, and multiple sclerosis. SWI, however, does not provide quantitative measures of magnetic susceptibility. This limitation is currently being addressed with the development of quantitative susceptibility mapping (QSM) and susceptibility tensor imaging (STI). While QSM treats susceptibility as isotropic, STI treats susceptibility as generally anisotropic characterized by a tensor quantity. This article reviews the basic principles of SWI, its clinical and research applications, the mechanisms governing brain susceptibility properties, and its practical implementation, with a focus on brain imaging. © 2014 Wiley Periodicals, Inc.

La modélisation des réseaux d’habitat en archéologie: trois expériences.

Directory of Open Access Journals (Sweden)

Laure Nuninger

2006-09-01

Full Text Available Cet article est le résultat d’une collaboration entre archéologues et géographes utilisant les principes d’un modèle classique d’analyse spatiale, le modèle de gravité, pour formaliser les interactions entre des établissements humains à des époques anciennes (y compris protohistoriques. Trois expériences ont été réunies afin de rendre compte de l’émergence d’une démarche et de son adaptation/enrichissement selon l’époque, l’espace considérés et les hypothèses sur l’organisation des sociétés correspondantes.

Comparison of Measurements and FluorMOD Simulations for Solar Induced Chlorophyll Fluorescence and Reflectance of a Corn Crop under Nitrogen Treatments [SIF and Reflectance for Corn

Science.gov (United States)

Middleton, Elizabeth M.; Corp, Lawrence A.; Campbell, Petya K. E.

2007-01-01

The FLuorescence Explorer (FLEX) satellite concept is one of six semifinalist mission proposals selected in 2006 for pre-Phase studies by the European Space Agency (ESA). The FLEX concept proposes to measure passive solar induced chlorophyll fluorescence (SIF) of terrestrial ecosystems. A new spectral vegetation Fluorescence Model (FluorMOD) was developed to include the effects of steady state SIF on canopy reflectance. We used our laboratory and field measurements previously acquired from foliage and canopies of corn (Zea mays L.) under controlled nitrogen (N) fertilization to parameterize and evaluate FluorMOD. Our data included biophysical properties, fluorescence (F) and reflectance spectra for leaves; reflectance spectra of canopies and soil; solar irradiance; plot-level leaf area index; and canopy SIF emissions determined using the Fraunhofer Line Depth principal for the atmospheric telluric oxygen absorption features at 688 nm (O2-beta) and 760 nm (O2-alpha). FluorMOD simulations implemented in the default "look-up-table" mode did not reproduce the observed magnitudes of leaf F, canopy SIF, or canopy reflectance. However, simulations for all of these parameters agreed with observations when the default FluorMOD information was replaced with measurements, although N treatment responses were underestimated. Recommendations were provided to enhance FluorMOD's potential utility in support of SIF field experiments and studies of agriculture and ecosystems.

Drug susceptibility testing in microaerophilic parasites: Cysteine strongly affects the effectivities of metronidazole and auranofin, a novel and promising antimicrobial

Directory of Open Access Journals (Sweden)

David Leitsch

2017-12-01

Full Text Available The microaerophilic parasites Entamoeba histolytica, Trichomonas vaginalis, and Giardia lamblia annually cause hundreds of millions of human infections which are treated with antiparasitic drugs. Metronidazole is the most often prescribed drug but also other drugs are in use, and novel drugs with improved characteristics are constantly being developed. One of these novel drugs is auranofin, originally an antirheumatic which has been relabelled for the treatment of parasitic infections. Drug effectivity is arguably the most important criterion for its applicability and is commonly assessed in susceptibility assays using in vitro cultures of a given pathogen. However, drug susceptibility assays can be strongly affected by certain compounds in the growth media. In the case of microaerophilic parasites, cysteine which is added in large amounts as an antioxidant is an obvious candidate because it is highly reactive and known to modulate the toxicity of metronidazole in several microaerophilic parasites.In this study, it was attempted to reduce cysteine concentrations as far as possible without affecting parasite viability by performing drug susceptibility assays under strictly anaerobic conditions in an anaerobic cabinet. Indeed, T. vaginalis and E. histolytica could be grown without any cysteine added and the cysteine concentration necessary to maintain G. lamblia could be reduced to 20%. Susceptibilities to metronidazole were found to be clearly reduced in the presence of cysteine. With auranofin the protective effect of cysteine was extreme, providing protection to concentrations up to 100-fold higher as observed in the absence of cysteine. With three other drugs tested, albendazole, furazolidone and nitazoxanide, all in use against G. lamblia, the effect of cysteine was less pronounced. Oxygen was found to have a less marked impact on metronidazole and auranofin than cysteine but bovine bile which is standardly used in growth media for G

Assays of residual antibiotics after treatment of γ-ray and UV irradiation

International Nuclear Information System (INIS)

Shin, Ji Hye; Nam, Ji Hyun; Lee, Dong Hun; Yu, Seung Ho; Lee, Myun Joo

2010-01-01

The pollution of antibiotics is a major cause of spreading antibiotics resistant bacteria in the environment. Applications of ozonation, UV, and γ-ray irradiations have been introduced to remove antibiotics in the effluents from wastewater treatment system. In this study, we compared the chemical (HPLC) and biological (antimicrobial susceptibility test, AMS) assays in measuring of the concentrations of residual antibiotics after γ-ray and UV irradiation. Most samples were degraded by γ-ray irradiation (1 ∼ 2 kGy). However, lincomycin and tetracycline were not degraded by UV irradiation. The concentration of residual antibiotics, that was treated with γ-ray and UV irradiation, measuring by bioassay was similar to HPLC. The concentrations of γ-ray irradiated cephradine measured by AMS test were 2 times higher than of HPLC assay, indicating AMS test is more sensitive than HPLC assay. These results indicate that γ-ray irradiation technique is more useful than UV irradiation, and biological assay is more useful to detect the antibiotics and toxic intermediates in antibiotics degradation

Comet assay as a human biomonitoring tool: application in occupational exposure to antineoplastic drugs

Directory of Open Access Journals (Sweden)

Carina Ladeira

2015-05-01

Occupational exposure to antineoplastic drugs is associated with genotoxic effects, although comet assay analyzed parameters were higher in exposed comparing with controls, were not significant. Also the study of the susceptibility biomarkers did not show statistical significant differences, the small size of our sample hampered the finding of a possible association, let alone a causality relationship.

Reference cells and ploidy in the comet assay

Directory of Open Access Journals (Sweden)

Gunnar eBrunborg

2015-02-01

Full Text Available In the comet assay, single cells are analyzed with respect to their level of DNA damage. Discrimination of the individual cell or cell type based on DNA content, with concomitant scoring of the DNA damage, is useful since this may allow analysis of mixtures of cells. Different cells can then be characterized based on their ploidy, cell cycle stage, or genome size. We here describe two applications of such a cell type-specific comet assay: (i Testicular cell suspensions, analyzed on the basis of their ploidy during spermatogenesis; and (ii reference cells in the form of fish erythrocytes which can be included as internal standards to correct for inter-assay variations. With standard fluorochromes used in the comet assay, the total staining signal from each cell – whether damaged or undamaged – was found to be associated with the cell’s DNA content. Analysis of the fluorescence intensity of single cells is straightforward since these data are available in scoring systems based on image analysis. The analysis of testicular cell suspensions provides information on cell type specific composition, susceptibility to genotoxicants, and DNA repair. Internal reference cells, either untreated or carrying defined numbers of lesions induced by ionizing radiation, are useful for investigation of experimental factors that can cause variation in comet assay results, and for routine inclusion in experiments to facilitate standardization of methods and comparison of comet assay data obtained in different experiments or in different laboratories. They can also be used - in combination with a reference curve - to quantify the DNA lesions induced by a certain treatment. Fish cells of a range of genome sizes, both greater and smaller than human, are suitable for this purpose and they are inexpensive.

50 Modélisation des propriétés diélectriques des nanocomposites ...

African Journals Online (AJOL)

AKA BOKO

3 Laboratoire de Physique des Solides et des Couches Minces, Faculté des Sciences,. Sémlalia ... renfort (fibres de verre, carbone ou Kevlar,..) ont alors été utilisés ... diélectrique. Par ailleurs, pour modéliser le comportement diélectrique à la.

A review of analyses of LOFT and semiscale tests made at IDAHO National Engineering Laboratory using RELAP5/MOD1

International Nuclear Information System (INIS)

Hall, P.C.

1984-03-01

Within the LOFT and Semiscale programs at INEL, many post-test analysis calculations have been performed using RELAP5/MOD1. In this report, these calculations are reviewed from the standpoint of assessing the performance of the code. Because the calculations were spread over a number of years, different cycles of RELAP5/MOD1 have been employed. Rather than explicitly assessing several cycles of the code, a more general view has been adopted and an attempt has been made to identify those areas in which the code is systematically successful or alternatively, frequently experiences difficulties. (author)

RELAP5/MOD2 implementation on various mainframes including the IBM and SX-2 supercomputer

International Nuclear Information System (INIS)

DeForest, D.L.; Hassan, Y.A.

1987-01-01

The RELAP5/MOD2 (cycle 36.04) code is a one-dimensional, two-fluid, nonequilibrium, nonhomogeneous transient analysis code designed to simulate operational and accident scenarios in pressurized water reactors (PWRs). System models are solved using a semi-implicit finite difference method. The code was developed at EG and G in Idaho Falls under sponsorship of the US Nuclear Regulatory Commission (NRC). The major enhancement from RELAP5/MOD1 is the use of a six-equation, two-fluid nonequilibrium and nonhomogeneous model. Other improvements include the addition of a noncondensible gas component and the revision and addition of drag formulation, wall friction, and wall heat transfer. Several test cases were run to benchmark the IBM and SX-2 installations against the CDC computer and the CRAY-2 and CRAY/XMP. These included the Edward's pipe blow-down and two separate reflood cases developed to simulate the FLECHT-SEASET reflood test 31504 and a postcritical heat flux (CHF) test performed at Lehigh University

Vessel coolant mass depletion during a 5% SBLOCA in the Semiscale Mod-2C facility

International Nuclear Information System (INIS)

Shaw, R.A.; Loomis, G.G.

1985-01-01

Experimental results are presented from two 5% small-break loss-of-coolant accident (SBLOCA) simulations in the Semiscale Mod-2C facility. In performing the simulated 5% SBLOCAs, boundary conditions scaled from a pressurized water reactor (PWR) were used. The experiment was run with initial conditions typical of a PWR (15.6 MPa pressure and 35 K core differential temperature). The Mod-2C facility represents the state-of-the-art in small facilities scaled from PWRs. Phenomena which occurred during the transient included: primary fluid saturation (change from subcooled to saturated blowdown), break uncovery (a centerline break was simulated), condensation-induced liquid hold-up in the steam generator primary tubes, pump suction liquid seal formation and core level depression with resulting core rod temperature excursion, pump suction liquid seal clearance, loop fluid mass redistribution, and gradual core rewet. The influence of core bypass flow is also discussed. 11 refs., 13 figs

Optimisation de modèles de propagation à partir des données de ...

African Journals Online (AJOL)

optimisation radio dans les réseaux mobiles. Le présent article présente une étude comparative de cinq méthodes d'optimisation de modèles de propagation à savoir : La régression linéaire, la méthode de Newton de second ordre, le recuit ...

RELAP5/MOD3.3 assessment against MSIV closure events in Krsko NPP

International Nuclear Information System (INIS)

Parzer, I.

2002-01-01

The paper presents RELAP5/MOD3.3 analysis of two abnormal events occurred in Krsko NPP originating from sudden closure of Main Steam Isolation Valve (MSIV). Both events occurred before the SG replacement in 2000, the first one in September 1995 and the second one in January 1997. Valuable plant data were obtained from real plant transients and the RELAP5 code assessment was performed. Recently the last frozen version RELAP5/MOD3.3 has been released, before merging with another best-estimate thermalhydraulic system code TRAC into an integrated code. It is thus of utmost importance to assess models built in RELAP5 code against real plant transients before the code merger. A full twoloop plant model, developed at Jozef Stefan Institute (JSI), has been used for the analyses. The model includes old Westinghouse D4 type steam generators (SGs) with assumed 18% Utubes plugged in both steam generators. In the first case a malfunction in the MSIV in SG-1 caused inadvertent valve closure, while in the second case the valve stem has been broken in the SG-2, which also caused sudden valve closure.(author)

Three-dimensional equilibria and transport in RFX-mod: A description using stellarator tools

International Nuclear Information System (INIS)

Gobbin, M.; Bonfiglio, D.; Lorenzini, R.; Marrelli, L.; Martin, P.; Martines, E.; Momo, B.; Predebon, I.; Puiatti, M. E.; Spizzo, G.; Terranova, D.; Boozer, A. H.; Cooper, A. W.; Escande, D. F.; Hirshman, S. P.; Lore, J.; Sanchez, R.; Spong, D. A.; Pomphrey, N.

2011-01-01

RFX-mod self-organized single helical axis (SHAx) states provide a unique opportunity to advance 3D fusion physics and establish a common knowledge basis in a parameter region not covered by stellarators and tokamaks. The VMEC code has been adapted to the reversed-field pinch (RFP) to model SHAx equilibria in fixed boundary mode with experimental measurements as constraint. The averaged particle diffusivity over the helical volume, estimated with the Monte Carlo code ORBIT, has a neoclassical-like dependence on collisionality and does not show the 1/ν trend of un-optimized stellarators. In particular, the helical region boundary, corresponding to an electron transport barrier with zero magnetic shear and improved confinement, has been investigated using numerical codes common to the stellarator community. In fact, the DKES/PENTA codes have been applied to RFP for local neoclassical transport computations, including radial electric field, to estimate thermal diffusion coefficients in the barrier region for typical RFX-mod temperature and density profiles. A comparison with power balance estimates shows that residual chaos due to secondary tearing modes and small-scale turbulence still contribute to drive anomalous transport in the barrier region.

Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease

Directory of Open Access Journals (Sweden)

Margoth Moreno

2010-11-01

Full Text Available Therapeutic failure of benznidazole (BZ is widely documented in Chagas disease and has been primarily associated with variations in the drug susceptibility of Trypanosoma cruzi strains. In humans, therapeutic success has been assessed by the negativation of anti-T. cruzi antibodies, a process that may take up to 10 years. A protocol for early screening of the drug resistance of infective strains would be valuable for orienting physicians towards alternative therapies, with a combination of existing drugs or new anti-T. cruzi agents. We developed a procedure that couples the isolation of parasites by haemoculture with quantification of BZ susceptibility in the resultant epimastigote forms. BZ activity was standardized with reference strains, which showed IC50 to BZ between 7.6-32 µM. The assay was then applied to isolates from seven chronic patients prior to administration of BZ therapy. The IC50 of the strains varied from 15.6 ± 3-51.4 ± 1 µM. Comparison of BZ susceptibility of the pre-treatment isolates of patients considered cured by several criteria and of non-cured patients indicates that the assay does not predict therapeutic outcome. A two-fold increase in BZ resistance in the post-treatment isolates of two patients was verified. Based on the profile of nine microsatellite loci, sub-population selection in non-cured patients was ruled out.

Design of a New Optical System for Alcator C-Mod Motional Stark Effect Diagnostic

International Nuclear Information System (INIS)

Ko, Jinseok; Scott, Steve; Bitter, Manfred; Lerner, Scott

2009-01-01

The motional Stark effect (MSE) diagnostic on Alcator C-Mod uses an in-vessel optical system (five lenses and three mirrors) to relay polarized light to an external polarimeter because port access limitations on Alcator C-Mod preclude a direct view of the diagnostic beam. The system experiences unacceptable, spurious drifts of order several degrees in measured pitch angle over the course of a run day. Recent experiments illuminated the MSE diagnostic with polarized light of fixed orientation as heat was applied to various optical elements. A large change in measured angle was observed as two particular lenses were heated, indicating that thermal-stress-induced birefringence is a likely cause of the spurious variability. Several new optical designs have been evaluated to eliminate the affected in-vessel lenses and to replace the focusing they provide with curved mirrors; however, ray tracing calculations imply that this method is not feasible. A new approach is under consideration that utilizes in situ calibrations with in-vessel reference polarized light sources. 2008 American Institute of Physics.

Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals

OpenAIRE

Cordeiro,Rossana de Aguiar; Astete-Medrano,Delia Jessica; Marques,Francisca Jakelyne de Farias; Andrade,Heuziwanne Tavares Leite; Perdigão Neto,Lauro Vieira; Tavares,Juliane Lira; Lima,Rita Amanda Chaves de; Patoilo,Kharla Kharolyni Nobre Rabelo; Monteiro,Andre Jalles; Brilhante,Raimunda Sâmia Nogueira; Rocha,Marcos Fábio Gadelha; Camargo,Zoilo Pires de; Sidrim,José Júlio Costa

2011-01-01

The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amp...

Control of substrate oxidation in MOD cerawwwmic coating on low-activation ferritic steel with reduced-pressure atmosphere

Science.gov (United States)

Tanaka, Teruya; Muroga, Takeo

2014-12-01

An Er2O3 ceramic coating fabricated using the metal-organic decomposition (MOD) method on a Cr2O3-covered low-activation ferritic steel JLF-1 substrate was examined to improve hydrogen permeation barrier performance of the coating. The Cr2O3 layer was obtained before coating by heat treating the substrate at 700 °C under reduced pressures of baking. Preprocessing to obtain a Cr2O3 layer would provide flexibility in the coating process for blanket components and ducts. Moreover, the Cr2O3 layer suppressed hydrogen permeation through the JLF-1 substrate. While further optimization of the coating fabrication process is required, it would be possible to suppress hydrogen permeation significantly by multilayers of Cr2O3 and MOD oxide ceramic.

ModFossa: A library for modeling ion channels using Python.

Science.gov (United States)

Ferneyhough, Gareth B; Thibealut, Corey M; Dascalu, Sergiu M; Harris, Frederick C

2016-06-01

The creation and simulation of ion channel models using continuous-time Markov processes is a powerful and well-used tool in the field of electrophysiology and ion channel research. While several software packages exist for the purpose of ion channel modeling, most are GUI based, and none are available as a Python library. In an attempt to provide an easy-to-use, yet powerful Markov model-based ion channel simulator, we have developed ModFossa, a Python library supporting easy model creation and stimulus definition, complete with a fast numerical solver, and attractive vector graphics plotting.

Modélisation environnementale de l'estuaire de la Seine

OpenAIRE

Bacq, Nicolas; Cugier, Philippe; Grasso, Florent; Le Gendre, Romain; Le Hir, Pierre; Lemoine, Jean-philippe; Riou, Philippe; Schulz, Elisabeth; Thouvenin, Benedicte; Verney, Romaric

2015-01-01

Dans le cadre du programme de recherche Seine-Aval 5, différentes stratégies de modélisation numérique sont mises en place pour aider à répondre aux questionnements scientifiques et sociétaux associés au fonctionnement physique, biologique, chimique et écologique de l'estuaire de la Seine (ex. projets RESET et HYMOSED). Les forçages météo-marins (vent, vague, marée) et hydrologique (débit) contrôlent le fonctionnement hydro-morpho-sédimentaire et biogéochimique de l'estuaire, modifiant ainsi ...

Les adakites d'Equateur : modèle préliminaire

OpenAIRE

Monzier, Michel; Robin, Claude; Hall, M.L.; Cotten, J.; Mothes, P.; Eissen, Jean-Philippe; Samaniego, P.

1997-01-01

L'ensemble des roches de 12 volcans quaternaires des Andes équatoriennes (286 analyses nouvelles) présente une signature adakitique, plus ou moins forte selon les appareils. Cette signature proviendrait de la fusion partielle de matériaux basaltiques métamorphisés de la croûte continentale (MORB et/ou basaltes d'arc) sous l'action des remontées magmatiques d'origine mantellique. Un modèle pétrogénétique préliminaire est proposé, qui explique les grands traits d'ensemble de la géochimie des vo...

Edge Thomson scattering on RFX-mod

International Nuclear Information System (INIS)

Alfier, A.; Pasqualotto, R.

2006-01-01

Electron temperature and density profiles of the RFX-mod experiment are characterized by edge gradients typically steeper than the flatter central region. The main Thomson scattering (TS) diagnostic which measures 84-point profiles along a diameter is mainly devoted to cover the core region. A second TS system has been developed to measure 12-point profiles in the external region 0.8< r/a<1, with a spatial resolution of 1 cm. It uses a single shot ruby laser. Input and collection optics share the same vacuum port and they are mounted on one optical bench, which allows offline aligning the system before connecting it to the vessel. The scattered signal is collected by a row of 12 fibers, while 4 fibers on the sides are used to check the alignment and measure the plasma light. The fibers, arranged in a 4x4 pattern, are fed into a four channel filter spectrometer and the spectrum is detected by a GaAs intensified charge-coupled device camera. The filters are arranged in a zigzag geometry, such that only one detector is needed

Neutral particle dynamics in the Alcator C-Mod tokamak

Energy Technology Data Exchange (ETDEWEB)

Niemczewski, Artur P. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

1995-08-01

This thesis presents an experimental study of neutral particle dynamics in the Alcator C-Mod tokamak. The primary diagnostic used is a set of six neutral pressure gauges, including special-purpose gauges built for in situ tokamak operation. While a low main chamber neutral pressure coincides with high plasma confinement regimes, high divertor pressure is required for heat and particle flux dispersion in future devices such as ITER. Thus we examine conditions that optimize divertor compression, defined here as a divertor-to-midplane pressure ratio. We find both pressures depend primarily on the edge plasma regimes defined by the scrape-off-layer heat transport. While the maximum divertor pressure is achieved at high core plasma densities corresponding to the detached divertor state, the maximum compression is achieved in the high-recycling regime. Variations in the divertor geometry have a weaker effect on the neutral pressures. For otherwise similar plasmas the divertor pressure and compression are maximum when the strike point is at the bottom of the vertical target plate. We introduce a simple flux balance model, which allows us to explain the divertor neutral pressure across a wide range of plasma densities. In particular, high pressure sustained in the detached divertor (despite a considerable drop in the recycling source) can be explained by scattering of neutrals off the cold plasma plugging the divertor throat. Because neutrals are confined in the divertor through scattering and ionization processes (provided the mean-free-paths are much shorter than a typical escape distance) tight mechanical baffling is unnecessary. The analysis suggests that two simple structural modifications may increase the divertor compression in Alcator C-Mod by a factor of about 5. Widening the divertor throat would increase the divertor recycling source, while closing leaks in the divertor structure would eliminate a significant neutral loss mechanism.

High performance discharges and capabilities in Alcator C-Mod

International Nuclear Information System (INIS)

Porkolab, M.

1996-01-01

Alcator C-Mod is a compact, diverted, shaped, high magnetic field (B = 9 T) tokamak operating at the Massachusetts Institute of Technology Plasma Fusion Center. The machine interior is all metallic, and the walls and divertor region are covered with molybdenum tiles. The vacuum vessel is a continuous, thick wall stainless steel construction, prototypical of future fusion devices (e.g., ITER). Typical discharge cleaning utilizes ECDC, or electron-cyclotron discharge cleaning, in the steady state at low magnetic field (0.0875 T). While its dimensions are compact (R = 0.67 m, a = 0.22 m, K = 1.8), C-Mod is designed to operate up to 2.5 MA at 9.0 T magnetic field. To present date the machine has operated at currents up to 1.5 MA at B = 5.3 T, and magnetic fields up to 8.0 T at I p = 1.2 MA. Due to the high current density, line average densities of 4.0 x 10 20 m -3 are obtained with gas fueling, and peak densities in excess of 1.0 x 10 21 m -3 have been obtained with pellet fueling. Typical pulse lengths are up to 2.0 seconds, with a flat-top of typically 1.0 sec. Presently the device is equipped with 4.0 MW of ICRF heating power operating at 80 MHz, but this capability is being upgraded to 8.0 MW with the addition of 4.0 MW of tunable ICRF power operating at 40.80 MHz. A 20 pellet/pulse deuterium injector is operational, and a 4 pellet Li injector is also operational. To reduce the influx of metallic impurities during high power operation, recently boronization of the machine interior was begun prior to plasma discharges, this allowed plasma operation with full auxiliary power capability without excessive radiative power losses from the plasma core. 7 refs

Neutral particle dynamics in the Alcator C-Mod tokamak

International Nuclear Information System (INIS)

Niemczewski, A.P.

1995-08-01

This thesis presents an experimental study of neutral particle dynamics in the Alcator C-Mod tokamak. The primary diagnostic used is a set of six neutral pressure gauges, including special-purpose gauges built for in situ tokamak operation. While a low main chamber neutral pressure coincides with high plasma confinement regimes, high divertor pressure is required for heat and particle flux dispersion in future devices such as ITER. Thus we examine conditions that optimize divertor compression, defined here as a divertor-to-midplane pressure ratio. We find both pressures depend primarily on the edge plasma regimes defined by the scrape-off-layer heat transport. While the maximum divertor pressure is achieved at high core plasma densities corresponding to the detached divertor state, the maximum compression is achieved in the high-recycling regime. Variations in the divertor geometry have a weaker effect on the neutral pressures. For otherwise similar plasmas the divertor pressure and compression are maximum when the strike point is at the bottom of the vertical target plate. We introduce a simple flux balance model, which allows us to explain the divertor neutral pressure across a wide range of plasma densities. In particular, high pressure sustained in the detached divertor (despite a considerable drop in the recycling source) can be explained by scattering of neutrals off the cold plasma plugging the divertor throat. Because neutrals are confined in the divertor through scattering and ionization processes (provided the mean-free-paths are much shorter than a typical escape distance) tight mechanical baffling is unnecessary. The analysis suggests that two simple structural modifications may increase the divertor compression in Alcator C-Mod by a factor of about 5. Widening the divertor throat would increase the divertor recycling source, while closing leaks in the divertor structure would eliminate a significant neutral loss mechanism. 146 refs., 82 figs., 14 tabs

Evaluation of fuel-temperature feedback mechanisms in TRAC-PF1/MOD2/NESTLE

International Nuclear Information System (INIS)

Knepper, Paula L.; Feltus, Madeline; Hochreiter, L.E.; Ivanov, Kostadin

1999-01-01

Coupled spatial kinetics and thermal-hydraulics system codes provide a means to model transient nuclear reactor behavior more accurately. Transients marked by strong perturbations, both with thermal-hydraulics and neutronics, such as a control-rod ejection or a main steam-line break, are especially of interest. It is now feasible to model complex reactor behavior with a coupled thermal-hydraulics and spatial kinetics code that provides a means to forecast safety margins. Recently, the Transient Reactor Analysis Code (TRAC)-PF1/MOD2, Version 5.4.25, was coupled with the NESTLE code. This coupled code (TRAC-PF1/MOD2/NESTLE) is used to examine effective fuel-temperature models. The Electric Power Research Institute (EPRI) rod-ejection benchmark was analyzed to evaluate the influence of effective fuel temperature. The rod-ejection transient tests only the fuel-rod, heat-conduction coupling. The coolant thermal-hydraulic coupling is not tested because of the speed of the transient. The neutronics solution changes extremely rapidly, whereas the convective heat transfer at the fuel surface requires more time to influence the coolant temperature of the system. The need to model the response of the system coolant temperature is not crucial in this analysis. The influence of the effective fuel temperature is the key component of this study. Various models were examined using the coupled code to calculate effective fuel temperatures. The influence of different, effective fuel-temperature models on the coupled-code results is studied. Three effective fuel-temperature models are examined: (l) volume average effective fuel temperature, (2) the effective fuel-temperature model suggested by the Office of Economic Cooperation and Development (OECD) rod-ejection benchmark, and (3) the NESTLE effective fuel-temperature model. A discussion is provided describing the effective fuel-temperature models examined in TRAC-PF1/MOD2/NESTLE and the influence of effective fuel temperature in

Carbapenem-resistant and cephalosporin-susceptible: a worrisome phenotype among Pseudomonas aeruginosa clinical isolates in Brazil.

Science.gov (United States)

Campana, Eloiza Helena; Xavier, Danilo Elias; Petrolini, Fernanda Villas-Boas; Cordeiro-Moura, Jhonatha Rodrigo; Araujo, Maria Rita Elmor de; Gales, Ana Cristina

The mechanisms involved in the uncommon resistance phenotype, carbapenem resistance and broad-spectrum cephalosporin susceptibility, were investigated in 25 Pseudomonas aeruginosa clinical isolates that exhibited this phenotype, which were recovered from three different hospitals located in São Paulo, Brazil. The antimicrobial susceptibility profile was determined by CLSI broth microdilution. β-lactamase-encoding genes were investigated by PCR followed by DNA sequencing. Carbapenem hydrolysis activity was investigated by spectrophotometer and MALDI-TOF assays. The mRNA transcription level of oprD was assessed by qRT-PCR and the outer membrane proteins profile was evaluated by SDS-PAGE. Genetic relationship among P. aeruginosa isolates was assessed by PFGE. Carbapenems hydrolysis was not detected by carbapenemase assay in the carbapenem-resistant and cephalosporin-susceptible P. aueruginosa clinical isolates. OprD decreased expression was observed in all P. aeruginosa isolates by qRT-PCR. The outer membrane protein profile by SDS-PAGE suggested a change in the expression of the 46kDa porin that could correspond to OprD porin. The isolates were clustered into 17 genotypes without predominance of a specific PFGE pattern. These results emphasize the involvement of multiple chromosomal mechanisms in carbapenem-resistance among clinical isolates of P. aeruginosa, alert for adaptation of P. aeruginosa clinical isolates under antimicrobial selective pressure and make aware of the emergence of an uncommon phenotype among P. aeruginosa clinical isolates. Copyright © 2016 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.

Validation of one-dimensional module of MARS 2.1 computer code by comparison with the RELAP5/MOD3.3 developmental assessment results

International Nuclear Information System (INIS)

Lee, Y. J.; Bae, S. W.; Chung, B. D.

2003-02-01

This report records the results of the code validation for the one-dimensional module of the MARS 2.1 thermal hydraulics analysis code by means of result-comparison with the RELAP5/MOD3.3 computer code. For the validation calculations, simulations of the RELAP5 code development assessment problem, which consists of 22 simulation problems in 3 categories, have been selected. The results of the 3 categories of simulations demonstrate that the one-dimensional module of the MARS 2.1 code and the RELAP5/MOD3.3 code are essentially the same code. This is expected as the two codes have basically the same set of field equations, constitutive equations and main thermal hydraulic models. The results suggests that the high level of code validity of the RELAP5/MOD3.3 can be directly applied to the MARS one-dimensional module

A weighted least-squares lump correction algorithm for transmission-corrected gamma-ray nondestructive assay

International Nuclear Information System (INIS)

Prettyman, T.H.; Sprinkle, J.K. Jr.; Sheppard, G.A.

1993-01-01

With transmission-corrected gamma-ray nondestructive assay instruments such as the Segmented Gamma Scanner (SGS) and the Tomographic Gamma Scanner (TGS) that is currently under development at Los Alamos National Laboratory, the amount of gamma-ray emitting material can be underestimated for samples in which the emitting material consists of particles or lumps of highly attenuating material. This problem is encountered in the assay of uranium and plutonium-bearing samples. To correct for this source of bias, we have developed a least-squares algorithm that uses transmission-corrected assay results for several emitted energies and a weighting function to account for statistical uncertainties in the assay results. The variation of effective lump size in the fitted model is parameterized; this allows the correction to be performed for a wide range of lump-size distributions. It may be possible to use the reduced chi-squared value obtained in the fit to identify samples in which assay assumptions have been violated. We found that the algorithm significantly reduced bias in simulated assays and improved SGS assay results for plutonium-bearing samples. Further testing will be conducted with the TGS, which is expected to be less susceptible than the SGS to systematic source of bias

Mod-ϕ convergence normality zones and precise deviations

CERN Document Server

Féray, Valentin; Nikeghbali, Ashkan

2016-01-01

The canonical way to establish the central limit theorem for i.i.d. random variables is to use characteristic functions and Lévy’s continuity theorem. This monograph focuses on this characteristic function approach and presents a renormalization theory called mod-ϕ convergence. This type of convergence is a relatively new concept with many deep ramifications, and has not previously been published in a single accessible volume. The authors construct an extremely flexible framework using this concept in order to study limit theorems and large deviations for a number of probabilistic models related to classical probability, combinatorics, non-commutative random variables, as well as geometric and number-theoretical objects. Intended for researchers in probability theory, the text is carefully well-written and well-structured, containing a great amount of detail and interesting examples. .

Self-similar current decay experiment in RFX-mod

International Nuclear Information System (INIS)

Zanca, Paolo

2007-01-01

The self-similar current decay (SSCD) has been suggested as a promising operation for reversed field pinch devices by numerical simulations, which show a decrease in modes amplitude and stochasticity when the magnetic field is forced to decay at a suitable rate at a fixed radial profile (Nebel et al 2002 Phys. Plasmas 9 4968). The first experimental test of SSCD has recently been performed in RFX-mod. An initial fast decrease in the mode amplitudes (about 40% of the initial value) is observed. After that, a regime characterized by transient states close to the single-helicity condition (Cappello and Paccagnella 1992 Phys. Fluids B 4 611, Finn et al 1992 Phys. Fluids B 4 1262) is established. This brings about a 50% increase in the global confinement parameters

Un modèle cognitif computationnel de représentation de la connaissance au sein des environnements virtuels d’apprentissage

Directory of Open Access Journals (Sweden)

Mehdi Najjar

2005-01-01

Full Text Available Dans le cadre de la représentation des connaissances au sein des environnements virtuels d’apprentissage (EVA et du fait de la nature relationnelle et structurée de ces connaissances, leur exploitation nécessite de faire appel à des processus d’analyse capables de traiter et de manipuler un grand volume de données structurées. Dans ce sens, un modèle de représentation trouve sa pleine utilité pour la recherche et le traitement automatique d’information guidant le raisonnement, le diagnostic et la prédiction d’un système tuteur dont la tâche est de fournir des suggestions, des exemples et des explications bien adaptés à chaque apprenant. Nous présentons dans cet article un modèle pour représenter la connaissance du domaine et celle des usagers utilisant des EVA. Le modèle s’inspire des recherches en intelligence artificielle sur la modélisation computationnelle et des théories de la psychologie cognitive qui expliquent l’activité cognitive humaine en termes de sous-systèmes de la mémoire et de leurs processus. Ces sous-systèmes (implémentés dans un EVA, parce qu’ils sont similaires à ceux utilisés par l’apprenant, facilitent, d’une part, l’identification de la connaissance acquise correcte ou erronée, et suggèrent, d’autre part, la planification d’une séquence d’activités pédagogiques pour améliorer de manière significative le niveau cognitif de cet apprenant.

Design and operating experience on the U.S. Department of Energy Experimental Mod-O 100 kW Wind Turbine

Science.gov (United States)

Glasgow, J. C.; Birchenough, A. G.

1978-01-01

The Mod-O 100 kW Experimental Wind Turbine was designed and fabricated by NASA, as part of the Federal Wind Energy Program, to assess technology requirements and engineering problems of large wind turbines. The machine became operational in October 1975 and has demonstrated successful operation in all of its design modes. During the course of its operations the machine has generated a wealth of experimental data and has served as a prototype developmental test bed for the Mod-OA operational wind turbines which are currently used on utility networks. This paper describes the mechanical and control systems as they evolved in operational tests and describes some of the experience with various systems in the downwind rotor configuration.

Transient simulation of ALWR passive safety systems using RELAP5/MOD2

International Nuclear Information System (INIS)

Elias, E.; Nekhamkin, Y.; Arshavski, I.

2004-01-01

Numerical simulation is presented of some passive safety systems currently incorporated in the design of the next generation advanced light water reactors (ALWRs). The performance and effectiveness of ex-core natural convection cooling and the concept of gravity driven water injection at high pressure are investigated using the RELAP5/MOD2 thermal-hydraulic code. The study identifies areas that should be investigated more fully in future experimental programs related to hypothetical large and small LOCA in ALWRs. (author)

Assessment of Human Bio-Behavior During Gait Process Using LifeMOD Software

Directory of Open Access Journals (Sweden)

Liliana Rogozea

2011-01-01

Full Text Available In this paper we present a set of observations concerning the
analysis and assessment of human bio-behavior during gait process. In the first part of the paper the fundamental and theoretical considerations of the gait process are approached and aspects connected to malfunctions are expressed. In the second part of the paper we present the modeling methodology using
the LifeMOD software, while in the third part the results and conclusions are presented.

Evaluation of piping heat transfer, piping flow regimes, and steam generator heat transfer for the Semiscale Mod-1 isothermal tests

International Nuclear Information System (INIS)

French, R.T.

1975-08-01

Selected experimental data pertinent to piping heat transfer, transient fluid flow regimes, and steam generator heat transfer obtained during the Semiscale Mod-1 isothermal blowdown test series (Test Series 1) are analyzed. The tests in this first test series were designed to provide counterparts to the LOFT nonnuclear experiments. The data from the Semiscale Mod-1 intact and broken loop piping are evaluated to determine the surface heat flux and average heat transfer coefficients effective during the blowdown transient and compared with well known heat transfer correlations used in the RELAP4 computer program. Flow regimes in horizontal pipe sections are calculated and compared with data obtained from horizontal and vertical densitometers and with an existing steady state flow map. Effects of steam generator heat transfer are evaluated quantitatively and qualitatively. The Semiscale Mod-1 data and the analysis presented in this report are valuable for evaluating the adequacy and improving the predictive capability of analytical models developed to predict system response to piping heat transfer, piping flow regimes, and steam generator heat transfer during a postulated loss-of-coolant accident (LOCA) in a pressurized water reactor (PWR). 16 references. (auth)

Design and initial testing of a one-bladed 30-meter-diameter rotor on the NASA/DOE mod-O wind turbine

Science.gov (United States)

Corrigan, R. D.; Ensworth, C. B. F.

1986-01-01

The concept of a one-bladed horizontal-axis wind turbine has been of interest to wind turbine designers for many years. Many designs and economic analyses of one-bladed wind turbines have been undertaken by both United States and European wind energy groups. The analyses indicate significant economic advantages but at the same time, significant dynamic response concerns. In an effort to develop a broad data base on wind turbine design and operations, the NASA Wind Energy Project Office has tested a one-bladed rotor at the NASA/DOE Mod-O Wind Turbine Facility. This is the only known test on an intermediate-sized one-bladed rotor in the United States. The 15.2-meter-radius rotor consists of a tip-controlled blade and a counterweight assembly. A rigorous test series was conducted in the Fall of 1985 to collect data on rotor performance, drive train/generator dynamics, structural dynamics, and structural loads. This report includes background information on one-bladed rotor concepts, and Mod-O one-bladed rotor test configuration, supporting design analysis, the Mod-O one-blade rotor test plan, and preliminary test results.

Impact du BAO électronique sur l’intention d’achat du consommateur:Le rôle modérateur de l’âge et du genre

Directory of Open Access Journals (Sweden)

Manel Hamouda

2014-03-01

Full Text Available Les variables sociodémographiques tels que l’âge et le genre sont considérées comme des variables très importantes en comportement du consommateur que ce soit dans un contexte réel ou dans un environnement virtuel. A cet égard, cette recherche se propose d’étudier le rôle de l’âge et du genre dans la relation entre l’intention d’achat du consommateur et le Bouche à oreille électronique (BAO électronique. Les données utilisées dans cette recherche ont été collectées à travers une étude empirique menée sur un échantillon de 204 internautes. Les résultats indiquent que le genre et l’âge constituent deux variables susceptibles de modérer l’intention d’achat du consommateur suite à une exposition à un BAO électronique. Les implications inhérentes pour les chercheurs ainsi que pour les praticiens ont été par ailleurs suggérées.

Utility of a Multiplex PCR Assay for Detecting Herpesvirus DNA in Clinical Samples

Science.gov (United States)

Druce, Julian; Catton, Mike; Chibo, Doris; Minerds, Kirsty; Tyssen, David; Kostecki, Renata; Maskill, Bill; Leong-Shaw, Wendy; Gerrard, Marie; Birch, Chris

2002-01-01

A multiplex PCR was designed to amplify herpes simplex virus types 1 and 2, cytomegalovirus, and varicella-zoster virus DNA present in a diverse range of clinical material. The susceptibility of these viruses to in vivo inhibition by at least one antiviral drug was an important consideration in their inclusion in the multiplex detection system. An aliquot of equine herpesvirus was introduced into each specimen prior to extraction and served as an indicator of potential inhibitors of the PCR and a detector of suboptimal PCR conditions. Compared to virus isolation and immunofluorescence-based antigen detection, the multiplex assay yielded higher detection rates for all viruses represented in the assay. The turnaround time for performance of the assay was markedly reduced compared to those for the other techniques used to identify these viruses. More than 21,000 tests have been performed using the assay. Overall, the multiplex PCR enabled the detection of substantially increased numbers of herpesviruses, in some cases in specimens or anatomical sites where previously they were rarely if ever identified using traditional detection methods. PMID:11980951

Experimental/theoretical comparisons of the turbulence in the scrape-off-layers of Alcator C-Mod, DIII-D, and NSTX

International Nuclear Information System (INIS)

Terry, J.L. . E-mail : terry@psfc.mit.edu; Zweben, S.J.; Rudakov, D.L.

2003-01-01

The intermittent turbulent transport in the scrape-off-layers of Alcator C-Mod, DIII-D, and NSTX is studied experimentally. On DIII-D the fluctuations of both density and temperature have strongly non-Gaussian statistics, and events with amplitudes above 10 times the mean level are responsible for large fractions of the net particle and heat transport, indicating the importance of turbulence on the transport. In C-Mod and NSTX the turbulence is imaged with a very high density of spatial measurements. The 2-D structure and dynamics of emission from a localized gas puff are observed, and intermittent features (also sometimes called 'blobs') are typically seen. On DIII-D the turbulence is imaged using BES and similar intermittent features are seen. The dynamics of these intermittent features are discussed. The experimental observations are compared with numerical simulations of edge turbulence. The electromagnetic turbulence in a 3-D geometry is computed using non-linear plasma fluid equations. The wavenumber spectra in the poloidal dimension of the simulations are in reasonable agreement with those of the C-Mod experimental images once the response of the optical system is accounted for. The resistive ballooning mode is the dominant linear instability in the simulations. (author)

Boundary plasma heat flux width measurements for poloidal magnetic fields above 1 Tesla in the Alcator C-Mod tokamak

Science.gov (United States)

Brunner, Dan; Labombard, Brian; Kuang, Adam; Terry, Jim; Alcator C-Mod Team

2017-10-01

The boundary heat flux width, along with the total power flowing into the boundary, sets the power exhaust challenge for tokamaks. A multi-machine boundary heat flux width database found that the heat flux width in H-modes scaled inversely with poloidal magnetic field (Bp) and was independent of machine size. The maximum Bp in the database was 0.8 T, whereas the ITER 15 MA, Q =10 scenario will be 1.2 T. New measurements of the boundary heat flux width in Alcator C-Mod extend the international database to plasmas with Bp up to 1.3 T. C-Mod was the only experiment able to operate at ITER-level Bp. These new measurements are from over 300 plasma shots in L-, I-, and EDA H-modes spanning essentially the whole operating space in C-Mod. We find that the inverse-Bp dependence of the heat flux width in H-modes continues to ITER-level Bp, further reinforcing the empirical projection of 500 μm heat flux width for ITER. We find 50% scatter around the inverse-Bp scaling and are searching for the `hidden variables' causing this scatter. Supported by USDoE award DE-FC02-99ER54512.

Fluoromycobacteriophages for Rapid, Specific, and Sensitive Antibiotic Susceptibility Testing of Mycobacterium tuberculosis

Science.gov (United States)

Piuri, Mariana; Jacobs, William R.; Hatfull, Graham F.

2009-01-01

Rapid antibiotic susceptibility testing of Mycobacterium tuberculosis is of paramount importance as multiple- and extensively- drug resistant strains of M. tuberculosis emerge and spread. We describe here a virus-based assay in which fluoromycobacteriophages are used to deliver a GFP or ZsYellow fluorescent marker gene to M. tuberculosis, which can then be monitored by fluorescent detection approaches including fluorescent microscopy and flow cytometry. Pre-clinical evaluations show that addition of either Rifampicin or Streptomycin at the time of phage addition obliterates fluorescence in susceptible cells but not in isogenic resistant bacteria enabling drug sensitivity determination in less than 24 hours. Detection requires no substrate addition, fewer than 100 cells can be identified, and resistant bacteria can be detected within mixed populations. Fluorescence withstands fixation by paraformaldehyde providing enhanced biosafety for testing MDR-TB and XDR-TB infections. PMID:19300517

Effects of Insecticides on Strawberry Aphid Chaetosiphon fragaefolii (Cockerell on Resistant and Susceptible Strawberry Genotypes

Directory of Open Access Journals (Sweden)

Slobodan Milenković

2011-01-01

Full Text Available Strawberry aphid, Chaetosiphon fragaefolii (Cockerell, is the most important vector ofstrawberry virus. Breeding of genotypes resistant to this pest is an important preventivecontrol measure, which can be compatible with rational insecticide application. The aimof the paper was to determine effects of dimethoate and deltamethrin on C. fragaefoliipopulations reared on two strawberry genotypes different in susceptibility: susceptiblestrawberry cultivar Čačanska rana and medium resistant hybrid, zf/1/94/96 (Senga Fructarinax Del Norte. Lower toxicity of deltamethrin was observed (laboratory assay as well aslower biological efficacy of dimethoate at lower concentrations (field trial for specimensfrom C. fragaefolii population reared on susceptible strawberry cultivar Čačanska rana.

Analysis of loss of normal feedwater transient using RELAP5/MOD1/NSC; KNU1 plant simulation

International Nuclear Information System (INIS)