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Sample records for susan gilbert beck

  1. Susan Smith

    African Journals Online (AJOL)

    Owner

    Soveel lesers soveel lokmiddele soveel re- sponse kan gelys word om toegang tot die lees van poësie te registreer. 'n Resep om ge- trou of in ontrou na te volg, bestaan nie. Ge- lukkig nie. Susan Smith se (debuut)bundel lok my helaas nie deur die voorblad as vertrek- punt te neem nie. Aan visuele prikkelkrag gaan.

  2. Gilbert\\'s Syndrome

    Directory of Open Access Journals (Sweden)

    Erkan Cure

    2014-04-01

    Full Text Available Gilbert\\'s syndrome (GS is a benign condition that does not progress to chronic liver disease or fibrosis. GS diagnosis should be considered in patients with chronic elevation of unconjugated bilirubin. In these patients the presence of hemolysis and other diseases of the liver should be excluded. GS is an autosomal recessive disease. The mutation of UDP-glucuronyl transferase is seen in 10-16% of the population. There is a 70-80% decrease in bilirubin glucuronidation. In cases of unexplained indirect hyperbilirubinemia with no history of drugs, smoking or alcohol use, GS should be considered. Firstly, hemolysis should be excluded. It has been reported that having increased levels of indirect bilirubin lowers the incidence of carotid plaque and coronary artery disease in patients of GS. The antioxidation and resistance to oxidative stress status of patients with GS is known to be high. However, GS is associated with breast and colon cancer. Several studies have reported that liver transplantation from a patient with GS had no harm to himself or to the recipient. An exact relationship between schizophrenia and GS has not been demonstrated. GS patients have a risk of breast and colon cancer so frequent follow up may be recommended.

  3. [Gilbert syndrome].

    Science.gov (United States)

    Faragó, Bernadett; Melegh, Béla

    2008-07-06

    Gilbert disease is a benign disorder of the bilirubin conjugation, which affects 7-10% of the average population. The symptoms are usually only mild jaundice and the slightly elevated unconjugated bilirubin level, other laboratory tests and the liver functions are usually normal. In most cases, mutation of the UDP glucuronyltransferase gene leads to impaired bilirubin conjugation. Besides the usual laboratory methods, genetic analyses of the UDP glucuronyltransferase gene can help in the diagnosis. In 80-100% of the patients the (TA)-insertion in the promoter-region of the gene is present in homozygous - (TA) 7 /(TA) 7 - form, and leads to the decrease of the amount of functionally active enzyme. The role of missense mutations localized in the coding region has not been clarified yet, but their co-occurrence with the (TA) 7 promoter-variant might mean an explanation to the elevated bilirubin level, jaundice, and the familiar aggregation of Gilbert disease.

  4. Ulrich Beck

    DEFF Research Database (Denmark)

    Sørensen, Mads P.; Christiansen, Allan

    Since the 1980s, Ulrich Beck has worked extensively on his theories of second modernity and the risk society. The book Ulrich Beck provides an extensive and thorough introduction to the German sociologist’s collected works. The book covers his sociology of work, his theories of individualization,...... of Ulrich Beck comes with a list of suggested further reading, as well as explanations of core terms. The book also includes a biography of Beck, and full bibliographies of his work in both English and German....

  5. Dedication - Susan L Greenblatt

    Science.gov (United States)

    Guberman, Steven L.

    2011-07-01

    Photo of Susan L Greenblatt Figure 1. Susan in May, 1994 This volume is dedicated to the memory of Susan L Greenblatt, the wife of Steven L Guberman. Susan attended 6 of the 8 dissociative recombination (DR) meetings. Her advice and wise counsel played a vital role in the organization of several of these meetings. The fifth meeting in Chicago in 2001 was her idea and it would not have occurred without her encouragement. Susan was always amused by the memory of the first group dinner at the second DR meeting at St Jacut in 1992. As we went around the dinner table identifying ourselves, it soon became her turn. Susan was a sociologist and after introducing herself she said: "I am not a chemist". A spontaneous chorus of attendees proclaimed "Neither are we!". Her husband and a few other chemists abstained. In 1983, Susan and I established the Institute for Scientific Research (ISR). The name was chosen so as to span sociology and chemical physics. Four years prior, an ophthalmologist had diagnosed a rare retinal condition of unknown origin and advised her to change her profession to one that did not involve reading. (She was able to read for the rest of her life.) Twenty years later we learned that the cause of the retinal and all her other health problems was a recently discovered rare mitochondrial mutation. Her experience with ophthalmologists and her life-long keen sense of injustice, led her to write a grant proposal to the US Department of Education to survey all ophthalmologists in the US to determine whether they were aware of and whether they told their patients about resources and aids that could help them to continue reading and participating in everyday activities. As part of the grant and based upon the survey results, she proposed to set up low-vision training programs for ophthalmology residents. We knew that the competition for funding was intense and included several well-known and more established organizations. Nevertheless, the proposal was funded

  6. Lewis, Prof. Gilbert Newton

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Lewis, Prof. Gilbert Newton. Date of birth: 25 October 1875. Date of death: 24 March 1946. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on ...

  7. Susan Flannery lahkub? / Harro Puusild

    Index Scriptorium Estoniae

    Puusild, Harro

    2008-01-01

    Ameerika teleseriaali "Vaprad ja ilusad" Stephanie Forresteri osatäitja Susan Flannery (1943) on seriaalis mänginud algusest peale s.o. 21 aastat. Lisatud intervjuu näitlejatariga. Sama ka Teleleht nr. 15, lk. 8-9 : ill

  8. Gilbert Omenn and his syndrome

    Directory of Open Access Journals (Sweden)

    Ahmad Al Aboud

    2012-01-01

    Full Text Available Gilbert Omenn is a well-known American Geneticist. In the 1965, He reported a rare genetic disorder —later known as Omenn syndrome. This syndrome is a variant of severe combined immunodeficiency which is associated with hypereosinophilia. It is one of the differential diagnoses of neonatal erythroderma.This concise report sheds light on Gilbert Omenn and the syndrome that bears his name.

  9. Gilbert Simondon: Information, Technology & Media

    OpenAIRE

    Mills, Simon

    2016-01-01

    Gilbert Simondon: Information, Technology and Media is a comprehensive introduction to the work of the French philosopher Gilbert Simondon. In particular it examines Simondon's original informational ontology, as developed from a synthesis of Cybernetics, thermodynamics and French epistemology, The book goes on to delineate the role this ontology plays in developing an original account of individuation in the physical, biological and psycho-social regimes. This is done, in part, through readi...

  10. Beck's Cosmopolitan Politics

    OpenAIRE

    Martell, Luke

    2008-01-01

    This article evaluates Ulrich Beck’s cosmopolitan global politics. I argue that areas where Beck sees bases for communal and cosmopolitan politics are structured by power, inequality and conflict. Beck has a conflict perspective on local responses to globalisation but this is not carried through to his global politics. There are issues that need to be tackled at a global level but I argue that this will have to be done on the basis of conflicting interests, power and nation-states as much as ...

  11. In Conversation with Susan Holtz | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2010-11-26

    Nov 26, 2010 ... Susan Holtz is a private consultant and Adjunct Professor in the Environmental Planning Department of the Nova Scotia College for Art and Design. As a consultant, Ms. Holtz specializes in energy, environment, and sustainable development policy, and works on related issues as a mediator and facilitator.

  12. Roberts, Dennis C. & Komives, Susan R.

    African Journals Online (AJOL)

    Enhancing Student Learning and Development in Cross-Border Higher Education, edited by. Dennis C. Roberts and Susan R. Komives, is a book that resulted from a short-term study-abroad experience between the Universities of Maryland and San Diego with the Qatar Foundation's Education City in Doha in 2010.

  13. Design package lazy susan for the fuel retrieval system

    Energy Technology Data Exchange (ETDEWEB)

    TEDESCHI, D.J.

    1999-09-10

    This is a design package that contains the details for a Lazy Susan style small tool for the Fuel Retrieval System. The Lazy Susan tool is used to help rotate an MCO Fuel Basket when loading it. This document contains requirements, development design information, tests and test reports that pertain to the production of Lazy Susan small tool.

  14. Psychoanalytic Interpretation of Blueberries by Susan Gibb

    OpenAIRE

    Zalbidea Paniagua, Maya

    2014-01-01

    [ES] La obra de ficción digital titulada Blueberries (2009) de Susan Gibb, publicada en la ELO (Organización de literatura electrónica) invita al lector/a a viajar dentro de la mente de la protagonista para descubrir sus experiencias reales e imaginarias en las que se examinan las nociones de género, sexo, cuerpo e identidad de una mujer traumatizada. En este artículo se exploran los modos verbales y visuales en esta ficción digital breve siguiendo patrones semióticos así como se interpretan ...

  15. 75 FR 38837 - Susan Harwood Training Grant Program, FY 2010

    Science.gov (United States)

    2010-07-06

    ...: Notification of Funding Opportunity for Susan Harwood Training Grant Program, FY 2010. Funding Opportunity No... project performance period is $250,000. DATES: Targeted Topic training grant applications must be received... Links section, and then select ``Susan Harwood Training Grant Program''. Please note that on the Harwood...

  16. Susan Lindquist: Visionary scientist and peerless mentor.

    Science.gov (United States)

    Bevis, Brooke J

    2017-01-02

    The science universe is dimmer after one of our brightest stars, Susan Lee Lindquist, was taken by cancer on October 27, 2016. Sue was an innovative, creative, out-of-the-box scientific thinker. She had unique biological intuition-an instinct for both the way things worked and the right questions to ask to uncover new research insights. Her wide-ranging career began with the study of protein folding and molecular chaperones, and she went on to show that protein folding can have profound and unexpected biological effects on such diverse processes as cancer, evolution, and neurodegenerative disease. As Sue's laboratory manager, I would like to offer a ground-floor perspective on what made her an exceptional scientist, mentor, and leader. She created a harmonious, collegial environment where collaborative synergy fueled meaningful progress that will impact science for decades to come. © 2017 Bevis.

  17. Psychoanalytic Interpretation of Blueberries by Susan Gibb

    Directory of Open Access Journals (Sweden)

    Maya Zalbidea Paniagua

    2014-06-01

    Full Text Available Blueberries (2009 by Susan Gibb, published in the ELO (Electronic Literature Organization, invites the reader to travel inside the protagonist’s mind to discover real and imaginary experiences examining notions of gender, sex, body and identity of a traumatised woman. This article explores the verbal and visual modes in this digital short fiction following semiotic patterns as well as interpreting the psychological states that are expressed through poetical and technological components. A comparative study of the consequences of trauma in the protagonist will be developed including psychoanalytic theories by Sigmund Freud, Jacques Lacan and the feminist psychoanalysts: Melanie Klein and Bracha Ettinger. The reactions of the protagonist will be studied: loss of reality, hallucinations and Electra Complex, as well as the rise of defence mechanisms and her use of the artistic creativity as a healing therapy. The interactivity of the hypermedia, multiple paths and endings will be analyzed as a literary strategy that increases the reader’s capacity of empathizing with the speaker.

  18. Susan Sontag — A Forgotten Mother?

    Directory of Open Access Journals (Sweden)

    Kludia Ziewiec

    2013-01-01

    Full Text Available The article discusses new and republished translations of Susan Sontag’s work, recently launched by the Karakter publishing house: Regarding the Pan of Others, On Photography, and Against Interpretation and Other Essays. The article focuses on the elements of Sontag’s thought that make her a forgotten mother of feminist and gender theoreticians, as well as such influential critics as Michel Foucault and Roland Barthes. The article points out to continuations of Sontag’s thought in contemporary theoretical and social projects, and to the pertinence of her critical observations on theories based on metaphysics of presence: psychoanalysis, Marxism, or hermeneutics. The article also touches upon history of war photography and related war journalism, and upon the ambivalent quality of imaging of the misery of war. It also present historical and cultural circumstances of the development of Sontag’s thought in the intellectual milieu of New York in the 1960s. The discussion recapitulates the main statements of Sontag’s essays, relating them to a wider theoretical context, which is aimed at a reappraisal of the forgotten intelectual in the history of literature.

  19. Meet EPA Scientist Susan Yee, Ph.D.

    Science.gov (United States)

    Susan Yee, Ph.D., is an ecologist at EPA's Gulf Ecology Division. She is working on the Puerto Rico Sustainable Communities program, developing decision support tools to evaluate how alternative decisions impact coastal ecosystem goods and services

  20. Pregnancy with gilbert syndrome - a case report.

    Science.gov (United States)

    Mohan, Mini; P, Lakshmi Sailaja; Reddy, Peddireddy Vijaya Narasimha

    2014-06-01

    A primigravida presented to us at 32 weeks of gestation with vomiting, myalgia and jaundice. On examination she had icterus, she was dehydrated, uterus was corresponding to dates and the fetal heart rate was good. On evaluation, all the investigations were normal except mild unconjugated hyperbilirubinaemia and hypoglycaemia. Based on the above findings we derived at a diagnosis of Gilbert syndrome. Dehydration due to vomiting aggravated her jaundice. On correcting her dehydration jaundice resolved, patient improved symptomatically and was discharged two days later. She was later admitted at term and underwent emergency caesarian section in view of fetal distress. Mother and baby were fine postoperatively and was discharged on the fifth postoperative day Gilbert syndrome is rare in obstetric practice. Virtually all patients have decreased activity of Uridine diphosphate glucuronosyl transferase (UDPGT). The case is reported due to its rarity.

  1. Susan swan and the female grotesque Susan swan and the female grotesque

    Directory of Open Access Journals (Sweden)

    Suzana Bornéo Funck

    2008-04-01

    Full Text Available Introduced to readers as “the tallest woman freelance writer in Canada”, Susan Swan belongs to a generation of writers whose experimental, innovative fiction has proved vital in the contemporary project of de/re/constructing narrative practice. Her 1983 novel The Biggest Modern Woman of the World constitutes an excellent example of what critic Linda Hutcheon has termed “historiographic metafiction”—”fiction that is intensely, self-reflexively art, but is also grounded in historical, social, and political realities” (Canadian 13. As a conscious engagement with social and historical contexts, such fiction aims at destabilizing and subverting accepted patterns of belief by reconceptualizing and narrating possible subjectivities. By means of intertextuality, especially parody, it engages in an ideological critique in terms of both sexual and national politics. Introduced to readers as “the tallest woman freelance writer in Canada”, Susan Swan belongs to a generation of writers whose experimental, innovative fiction has proved vital in the contemporary project of de/re/constructing narrative practice. Her 1983 novel The Biggest Modern Woman of the World constitutes an excellent example of what critic Linda Hutcheon has termed “historiographic metafiction”—”fiction that is intensely, self-reflexively art, but is also grounded in historical, social, and political realities” (Canadian 13. As a conscious engagement with social and historical contexts, such fiction aims at destabilizing and subverting accepted patterns of belief by reconceptualizing and narrating possible subjectivities. By means of intertextuality, especially parody, it engages in an ideological critique in terms of both sexual and national politics.

  2. Gilbert White talks about natural hazards

    Science.gov (United States)

    Spall, H.

    1978-01-01

    Dr. Gilbert White is Director of the Institute of Behavioral Science at the University of Colorado, Boulder, where he is responsible for natural Hazards Research and Applications Information Center supported by the National Science Foundation. He served in the Executive Office of the president in 1941-42, on the Federal Flood Control Policy Task Force in 1964-65, and on the U.S Geological Survey Advisory Panel on Earthquake Studies. Dr. White has authored five books on the social and economic aspects of natural resources, including water supply and river development, and on floods and other natural hazards. 

  3. Friends: Gilbert Romme and the Stroganovs

    Directory of Open Access Journals (Sweden)

    Victoria Sophia Frede

    2015-09-01

    Full Text Available This article analyzes the intersection of sentimental codes of friendship and pedagogical theory in Russia and France in the second half of the eighteenth century, concentrating on a single group, Aleksandr Stroganov, Pavel Stroganov, and Gilbert Romme. Reading their correspondence in tandem with treatises on friendship and education, the article investigates how such key concepts as equality and virtue were understood at their time. It further explores how they negotiated differences in status and age in constructing what they called a friendship.

  4. Gilbert ja George lasevad oma kunstiteose alla laadida

    Index Scriptorium Estoniae

    2007-01-01

    9.05.2007 öösel on kõigil soovijail võimalik tasuta interneti vahendusel omandada Londonis tegutseva kunstnikepaari Gilbert & George (Gilbert Proesch ja George Passmore) teos "Planed". Aadressid: www.bbc.co.uk/imagine ja www.guardian.co.uk/art

  5. Collaborative Internet Projects: An Interview with Susan Silverman about Her Passion and Hobby.

    Science.gov (United States)

    Strangman, Nicole

    2002-01-01

    Outlines an interview with Susan Silverman, an instructional technology integration teacher in the Comsewogue school district in Port Jefferson Station, New York. Describes Susan's transformation from technophobe to an innovator of collaborative Internet projects. (PM)

  6. Cognitive Therapist: A Dialogue with Aaron Beck.

    Science.gov (United States)

    Weinrach, Stephen G.

    1988-01-01

    Presents interview with cognitive therapist Aaron Beck in which Beck describes cognitive therapy; the contributions of Freud, Maslow, Rogers, and Ellis; cultural, class, and gender issues; training of cognitive-behavior therapists; and the future direction of treatment of anxiety and depression. (ABL)

  7. Adolf Beck: A forgotten pioneer in electroencephalography

    NARCIS (Netherlands)

    Coenen, A.M.L.; Fine, E.; Zayachkivska, O.

    2014-01-01

    Adolf Beck, born in 1863 at Cracow (Poland), joined the Department of Physiology of the Jagiellonian University in 1880 to work directly under the supervision of the prominent physiology professor, Napoleon Cybulski. Following his suggestion, Beck started experimental studies on the electrical brain

  8. [Gilbert Ballet (1853 - 1916). Reasonable psychiatry].

    Science.gov (United States)

    Vayre, Pierre

    2007-01-01

    Gilbert Ballet (1853-1916) was born into a medical family in the French province of Limousin. He completed a brilliant career in Paris hospitals: Resident (1875), Assistant to Professor Charcot of Salpêtrière Hospital (1882), Consultant (1884), Head of the Department of Neurology and Psychiatry (1890), and member of the Franch Academy of Medicine (1812). He had been teaching in the "Brain and mental diseases" course since 1891. In 1909, he held the chair of history of medicine. In 1911, he was Professor of mental diseases. He then advocated that nervous system disorders constituted a single thematic domain with two branches, organic neurology and psychiatry. He wrote a famous report on the forensic medicine assessment of criminal responsibility. His motto was "Let's use psychology as we can, not forgetting that we are physicians".

  9. Susan Dicklitch. The Elusive Promise of NGO's | Heck | Uganda ...

    African Journals Online (AJOL)

    Susan Dicklitch. The Elusive Promise of NGO's. Simon Heck. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/uj.v46i1.23044 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

  10. Kuu plaat : Beck "Guero". Plaadid kauplusest Lasering

    Index Scriptorium Estoniae

    2005-01-01

    Heliplaatidest: Beck "Guero", Common "Be", Stupid F ja Hash "Koodeks: R.L.V.", Kulo "Onarhia", Natalie Imbruglia "Counting Down the Days", New Order "Waiting for the Sirens' Call", Human Ground "Human Ground"

  11. The "Splendid Isolation" of Aaron T. Beck.

    Science.gov (United States)

    Rosner, Rachael I

    2014-12-01

    Aaron T. Beck's Cognitive Therapy (CT) is a school of psychotherapy, conceived in the 1960s, that is celebrated by many clinicians for having provided the scientific antidote to all that was wrong with psychoanalysis. This essay situates the origins of CT in the crisis of legitimacy in psychiatry in the 1960s and 1970s, when, among many charges, psycho- analysts had to face the accusation that analysis was not adequately scientific. Beck actually began his career as both a psychoanalyst and an experimentalist. Contrary to common triumphalist accounts, Beck created CT to be a neutral space, not a partisan one, in turbulent times. Other notable psychoanalysts also sought compromise, rather than partisanship, to bridge the transition to biomedical science. The biographical approach of this essay to the origins of Beck's CT both situates him historiographically and articulates the complex experiences of a generation of psychoanalysts otherwise opaque to standard narratives.

  12. Gilbert Lake: Mark Twain National Wildlife Refuge Complex : 1983

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for the Gilbert Lake District of Mark Twain National Wildlife Refuge summarizes Refuge activities during the 1983 calendar year. The...

  13. Hashimoto transform for stochastic Landau-Lifshitz-Gilbert equation

    OpenAIRE

    Neklyudov, Misha

    2014-01-01

    We show that Hashimoto transformation is applicable to the one dimensional stochastic Landau-Lifshitz-Gilbert (LLG) equation and transforms it to the stochastic generalized heat equation with nonlocal (in space) interaction.

  14. What is Orobanche haenseleri var. deludens Beck?

    Directory of Open Access Journals (Sweden)

    Pujadas Salvà, Antonio J.

    2004-12-01

    Full Text Available Orobanche haenseleri var. deludens Beck (Orobanchaceae, a problematic taxon described from Algeciras (Cádiz, S Spain is here identified after studying the original material of Wolley-Dod (BM 4476. It is considered to be the same as O. austrohispanica M.J.Y. Foley and better included, as a variety, under O. gracilis Sm. The new combination O. gracilis var. deludens (Beck A. Pujadas is consequently proposed. It mainly parasites Ulex (Fabaceae in the western Mediterranean Region (Iberian Peninsula and NW Africa.Se identifica Orobanche haenseleri var. deludens Beck (Orobanchaceae, un taxon conflictivo descrito de Algeciras (Cádiz, sur de España, a partir del análisis del material original de Wolley-Dod (BM 4476. Se considera que es lo mismo que O. austrohispanica M.J.Y. Foley, y se incluye en O. gracilis Sm. con rango varietal. Se propone la nueva combinación O. gracilis var. deludens (Beck A. Pujadas. Parasita principalmente a especies del género Ulex (Fabaceae en la Región Mediterránea Occidental (Península Ibérica y noroeste de África.

  15. [VISCOELASTISITY AND ELECTRICAL PARAMETERS OF ERYTHROCYTES IN GILBERT SYNDROME].

    Science.gov (United States)

    Kurilovich, S A; Nemtsova, E G; Kruchinina, M V; Maximov, V N

    2015-01-01

    Results of viscoelastic and electrical properties of erythrocytes study in patients with genetically confirmed Gilbert's syndrome (n = 81) are presented. Dielectrophoresis of erythrocytes in a nonuniform an alterning electric field was performed in81 patients with Gilbert's syndrome and in 20 persons of the comparison group without of the pathology identified by thelaboratory and instrumental examination. The significant differences in viscoelasticity properties of erythrocytes in Gilbert'ssyndrome were obtained. The amplitude of the deformation, the speed of movement to the electrodes and the polarizability on electric field's of all frequencies were significantly lower, but generalized rigidity index, viscosity, index of aggregationand degradation on electric field's of all frequencies were higher than in the comparison group. A number of electricalparameters (conductivity, the capacity of the cells and the relative polarizability) were also higher than in the comparisongroup. Some differences in the parameters of erythrocytes were obtained from homozygous and heterozygous carriers of A(TA), TAA of gene UGT1A1 promotor.

  16. Aaron Temkin Beck (born July 18, 1921- Biography

    Directory of Open Access Journals (Sweden)

    K. Fatih Yavuz

    2012-07-01

    Full Text Available he American Academy of Arts and Sciences in 2007. Beck is noted for his research in psychotherapy, psychopathology, suicide, and psychometrics, which led to his creation of cognitive therapy, for which he received the 2006 Lasker-DeBakey Clinical Medical Research Award, and the Beck Depression Inventory (BDI, one of the most widely used instruments for measuring depression severity. Beck is also known for his creation of the Beck Hopelessness Scale and the Beck Anxiety Inventory, and has founded the Beck Institute in Philadelphia, Pennsylvania, in which his daughter, Dr. Judith Beck, works. He is married with four children, Roy, Judy, Dan, and Alice. He has eight grandchildren.the American Academy of Arts and Sciences in 2007. Beck is noted for his research in psychotherapy, psychopathology, suicide, and psychometrics, which led to his creation of cognitive therapy, for which he received the 2006 Lasker-DeBakey Clinical Medical Research Award, and the Beck Depression Inventory (BDI, one of the most widely used instruments for measuring depression severity. Beck is also known for his creation of the Beck Hopelessness Scale and the Beck Anxiety Inventory, and has founded the Beck Institute in Philadelphia, Pennsylvania, in which his daughter, Dr. Judith Beck, works. He is married with four children, Roy, Judy, Dan, and Alice. He has eight grandchildren.

  17. Perturbation Theory For The Landau-Lifshits-Gilbert Equation

    Science.gov (United States)

    2012-09-01

    calculations for the response of a magnetic system to an external magnetic field, using the Landau-Lifshits-Gilbert ( LLG ) equation and a perturbation...convenient to first put this equation in Landau-Lifshits-Gilbert ( LLG ) form (2): if we define the torque vector 2 M H eff     and a dimensionless...magnetic field in the LLG equation as follows: mM Mst  (3) and h m , H Haeff     (4) where 0M Hast   and 0 0 0 0 0 0 N N Nz

  18. Effects of Landau-Lifshitz-Gilbert damping on domain growth

    Science.gov (United States)

    Kudo, Kazue

    2016-12-01

    Domain patterns are simulated by the Landau-Lifshitz-Gilbert (LLG) equation with an easy-axis anisotropy. If the Gilbert damping is removed from the LLG equation, it merely describes the precession of magnetization with a ferromagnetic interaction. However, even without the damping, domains that look similar to those of scalar fields are formed, and they grow with time. It is demonstrated that the damping has no significant effects on domain growth laws and large-scale domain structure. In contrast, small-scale domain structure is affected by the damping. The difference in small-scale structure arises from energy dissipation due to the damping.

  19. Is Gilbert syndrome a new risk factor for breast cancer?

    Science.gov (United States)

    Astolfi, Rafael Haddad; Bugano, Diogo Diniz Gomes; Francisco, Alice Aparecida Rodrigues Ferreira; de Souza, Marcelo Moreira Tavares; Ono-Nita, Suzane Kioko; Baracat, Edmund Chada

    2011-08-01

    Patients with Gilbert syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. Unwrapping the Thick Coat of Armor: A Conversation with Susan Albrecht

    Science.gov (United States)

    Kaff, Marilyn; Teagarden, Jim; Zabel, Robert

    2017-01-01

    Susan Albrecht's career has spanned more than 40 years. During those years she has served as an English teacher, school psychologist, behavior consultant, coordinator of services, and special education faculty member. Her contributions to the field include leadership positions with the Council for Children with Behavioral Disorders. Susan shared…

  1. Practitioner Profile: An Interview with Susan Bross, AFC®

    Directory of Open Access Journals (Sweden)

    Susan Bross

    2011-04-01

    Full Text Available

    Susan Bross is a nationally accredited financial counselor who established her private practice in 1992. She currently lives in San Rafael, California. She brings a multi-faceted background and a combination of skills to her work. As a financial counselor, she works with individuals, couples, and entrepreneurs throughout the nation to help clients develop a practical and emotionally healthy relationship with money. When asked, she will tell you that she is passionate about her work because it mirrors her own hard-won path with money. Readers of the Journal will find Ms. Bross’s approach to financial therapy inspiring. She teaches simple tools for effortless and sustainable cash flow and money management. She also guides her clients to balanced attitudes and beliefs about money and success.

  2. [The Durkheim Test. Remarks on Susan Leigh Star's Boundary Objects].

    Science.gov (United States)

    Gießmann, Sebastian

    2015-09-01

    The article reconstructs Susan Leigh Star's conceptual work on the notion of 'boundary objects'. It traces the emergence of the concept, beginning with her PhD thesis and its publication as Regions of the Mind in 1989. 'Boundary objects' attempt to represent the distributed, multifold nature of scientific work and its mediations between different 'social worlds'. Being addressed to several 'communities of practice', the term responded to questions from Distributed Artificial Intelligence in Computer Science, Workplace Studies and Computer Supported Cooperative Work (CSCW), and microhistorical approaches inside the growing Science and Technology Studies. Yet the interdisciplinary character and interpretive flexibility of Star’s invention has rarely been noticed as a conceptual tool for media theory. I therefore propose to reconsider Star's 'Durkheim test' for sociotechnical media practices.

  3. "The nature of morality‟ in Gilbert Harman: As appraisal | Oyedola ...

    African Journals Online (AJOL)

    This study examines Gilbert Harman's submission that moral beliefs are incapable of the sort of empirical confirmation characteristic of scientific beliefs, in his work, "The Nature of Morality.‟ This study argues that the incapability of moral beliefs to be empirically confirmed characteristic of scientific beliefs, as espoused by ...

  4. Portrait Face-Off: Gilbert Stuart vs. Peter Max

    Science.gov (United States)

    Crumpecker, Cheryl

    2012-01-01

    When art classes are short and infrequent, it is always a challenge to meet required state and national standards. A unit comparing and contrasting Peter Max's Pop art portraits with the realistic style of Gilbert Stuart's presidential portraits provides an opportunity to address a huge number of these requirements. Focus can change with the age…

  5. Backus-Gilbert inversion of travel time data

    Science.gov (United States)

    Johnson, L. E.

    1972-01-01

    Application of the Backus-Gilbert theory for geophysical inverse problems to the seismic body wave travel-time problem is described. In particular, it is shown how to generate earth models that fit travel-time data to within one standard error and having generated such models how to describe their degree of uniqueness. An example is given to illustrate the process.

  6. Right-lobe liver transplant from donors with Gilbert syndrome.

    Science.gov (United States)

    Demirbas, Tolga; Piskin, Turgut; Dayangac, Murat; Yaprak, Onur; Akyildiz, Murat; Tokat, Yaman; Yuzer, Yildiray

    2012-02-01

    Donor safety is one of the most important aspects of living-donor liver transplant. The preoperative evaluation of candidates for such transplants essentially starts with serologic and biochemical analyses. However, some potential liver donors with normal liver function test results may have isolated mild hyperbilirubinemia (serum indirect bilirubin level > 20.5 μmol/L [1.2 mg/dL]). Gilbert syndrome is an autosomal recessive condition that is a common cause of nonhemolytic unconjugated hyperbilirubinemia, and its prevalence is 3% to 10% in the healthy US population. Mild hyperbilirubinemia episodes are expected in people with Gilbert syndrome when they are exposed to physical stress, such as operative intervention or low energy intake. The liver morphologic findings of these individuals are normal; however, there is a debate on the use of people with Gilbert syndrome as living-liver donors. The purpose of this study was to assess the results of right-lobe living-donor hepatectomy of liver donors with Gilbert syndrome. Between 2004 and 2010, two hundred twenty-five living-donor liver transplants using right-lobe grafts were performed in our hospital. Donors with Gilbert syndrome were defined as those whose serum bilirubin level was greater than 20.5 μmol/L (1.2 mg/dL). Six of 225 right-lobe living-donor liver transplants were performed using donors with Gilbert syndrome. The median follow-up after transplant was 34 months (range, 18 to 51 mo). One week after the operation, the median bilirubin level for right-lobe liver donors was 34.5 μmol/L (2.02 mg/dL) (range, 17.1 to 51.3 μmol/L [1 to 3 mg/dL]), and the median prothrombin time (international normalized ratio) was 1.36 (range, 1.1 to 1.7). The median bilirubin level of the donors after 6 months was 29 μmol/L (1.7 mg/dL) (range, 20.5 to 41 μmol/L [1.2 to 2.4 mg/dL]). Living-donor liver transplant from Gilbert syndrome donors can be safely performed.

  7. Aaron Temkin Beck (born July 18, 1921-) Biography

    OpenAIRE

    K. Fatih Yavuz; M. Hakan Türkçapar

    2012-01-01

    he American Academy of Arts and Sciences in 2007. Beck is noted for his research in psychotherapy, psychopathology, suicide, and psychometrics, which led to his creation of cognitive therapy, for which he received the 2006 Lasker-DeBakey Clinical Medical Research Award, and the Beck Depression Inventory (BDI), one of the most widely used instruments for measuring depression severity. Beck is also known for his creation of the Beck Hopelessness Scale and the ...

  8. 77 FR 64973 - Don W. Gilbert Hydro Power, LLC; Notice of Application Accepted for Filing With the Commission...

    Science.gov (United States)

    2012-10-24

    ... Energy Regulatory Commission Don W. Gilbert Hydro Power, LLC; Notice of Application Accepted for Filing.... Date filed: May 30, 2012. d. Applicant: Don W. Gilbert Hydro Power, LLC. e. Name of Project: Gilbert... to: Federal Power Act, 16 U.S.C. 791(a)-825(r). (2006). h. Applicant Contact: Don W. Gilbert and De...

  9. Susan J. Quaal: the global and local impact of a transformational leader.

    Science.gov (United States)

    Finlay, L D

    1998-01-01

    To be a transformational leader in nursing, one must have forever changed the course of our practice. This article highlights the qualities of a great leader, Susan J. Quaal, PhD, APRN, CVS, CCRN. Described are examples of Susan's incredible clinical expertise and also the attributes that make her such a dynamic leader in all domains of the clinical nurse specialist role: Practitioner, educator/mentor, consultant, leader/administrator, and researcher. Interwoven in this article, you will also find the threads of humility and charity that make Susan such an extraordinary human being and a blessing to all the lives she touches.

  10. Beck's Song Reader: An Unbound Music Book

    OpenAIRE

    Maxwell, Kate

    2016-01-01

    This article is under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License. This article is also available via DOI:10.7202/1038035ar The pop/alternative musician Beck created a stir in the music world when he released his 2012 “album” Song Reader as a book compilation of individual pieces of sheet music. This included a guide to reading music notation, together with an introduction describing the work’s intentions and inviting readers to perform their own ...

  11. Obituary: James Gilbert Baker, 1914-2005

    Science.gov (United States)

    Baker, Neal Kenton

    2005-12-01

    Dr. James Gilbert Baker, renowned astronomer and optical physicist, died 29 June 2005 at his home in Bedford, New Hampshire at the age of 90. Although his scientific interest was astronomy, his extraordinary ability in optical design led to the creation of hundreds of optical systems that supported astronomy, aerial reconnaissance, instant photography (Polaroid SX70 camera), and the US space programs. He was the recipient of numerous awards for his creative work. He was born in Louisville, Kentucky, on 11 November 1914, the fourth child of Jesse B. Baker and Hattie M. Stallard. After graduating from Louisville DuPont Manual High, he went on to attend the University of Louisville majoring in Mathematics. He became very close to an Astronomy Professor, Dr. Moore, and many times used his telescopes to do nightly observations. While at the university, he built mirrors for his own telescopes and helped form the Louisville Astronomical Society in 1933. At the University of Louisville, he also met his future wife, Elizabeth Katherine Breitenstein of Jefferson County, Kentucky. He received his BA in 1935 at the height of the Depression. He began his graduate work in astronomy at the Harvard College Observatory. After his MA (1936), he was appointed a Junior Fellow (1937-1943) in the Prestigious Harvard Society of Fellows. He received his PhD in 1942 from Harvard in rather an unusual fashion, which is worth retelling. During an Astronomy Department dinner, Dr. Harlow Shapley (the director) asked him to give a talk. According to the "Courier-Journal Magazine", "Dr. Shapley stood up and proclaimed an on-the-spot departmental meeting and asked for a vote on recommending Baker for a Ph.D. on the basis of the 'oral exam' he had just finished. The vote was unanimous." It was at Harvard College Observatory during this first stage of his career that he collaborated with Donald H. Menzel, Lawrence H. Aller, and George H. Shortley on a landmark set of papers on the physical processes

  12. The Partition of the Gilbert and Ellice Islands

    Directory of Open Access Journals (Sweden)

    W. David McIntyre

    2012-05-01

    Full Text Available This paper reviews the separation of the Ellice Islands from the Gilbert and Ellice Islands Colony, in the central Pacific, in 1975: one of the few agreed boundary changes that were made during decolonization. Under the name Tuvalu, the Ellice Group became the world’s fourth smallest state and gained independence in 1978. The Gilbert Islands, (including the Phoenix and Line Islands, became the Republic of Kiribati in 1979. A survey of the tortuous creation of the colony is followed by an analysis of the geographic, ethnic, language, religious, economic, and administrative differences between the groups. When, belatedly, the British began creating representative institutions, the largely Polynesian, Protestant, Ellice people realized they were doomed to permanent minority status while combined with the Micronesian, half-Catholic, Gilbertese. To protect their identity they demanded separation, and the British accepted this after a UN-observed referendum.

  13. Periodic solutions for the Landau-Lifshitz-Gilbert equation

    OpenAIRE

    Huber, Alexander

    2010-01-01

    Ferromagnetic materials tend to develop very complex magnetization patterns whose time evolution is modeled by the so-called Landau-Lifshitz-Gilbert equation (LLG). In this paper, we construct time-periodic solutions for LLG in the regime of soft and small ferromagnetic particles which satisfy a certain shape condition. Roughly speaking, it is assumed that the length of the particle is greater than its hight and its width. The approach is based on a perturbation argument and the spectral anal...

  14. Comparison of the Image Rejection between the Passive and the Gilbert Mixer

    DEFF Research Database (Denmark)

    Wang, Xiaoyan; Andreani, Pietro

    2004-01-01

    This paper presents a comparison of the image rejection between Gilbert mixer and the passive mixer. A simple model for mixers is set up, and the image rejection performance of passive and Gilbert mixer is analyzed based on it. Simulations and calculations were done to compare the image rejection...... of the two mixers. The results show that the Gilbert mixer, comparing with the passive one, shows a stronger rejection to the amplitude error of the quadrature signals at its input....

  15. Periodic solutions for the Landau-Lifshitz-Gilbert equation

    Science.gov (United States)

    Huber, Alexander

    2011-03-01

    Ferromagnetic materials tend to develop very complex magnetization patterns whose time evolution is modeled by the so-called Landau-Lifshitz-Gilbert equation (LLG). In this paper, we construct time-periodic solutions for LLG in the regime of soft and small ferromagnetic particles which satisfy a certain shape condition. Roughly speaking, it is assumed that the length of the particle is greater than its hight and its width. The approach is based on a perturbation argument and the spectral analysis of the corresponding linearized problem as well as the theory of sectorial operators.

  16. Coexistence of Gilbert syndrome with hereditary haemolytic anaemias.

    Science.gov (United States)

    Rawa, Katarzyna; Adamowicz-Salach, Anna; Matysiak, Michal; Trzemecka, Anna; Burzynska, Beata

    2012-07-01

    Gilbert syndrome is an inherited disease characterised by mild unconjugated hyperbilirubinaemia caused by mutations in UGT1A1 gene which lead to decreased activity of UDP-glucuronosyltransferase 1A1. The most frequent genetic defect is a homozygous TA dinucleotide insertion in the regulatory TATA box in the UGT1A1 gene promoter. 182 Polish healthy individuals and 256 patients with different types of hereditary haemolytic anaemias were examined for the A(TA)(n)TAA motif. PCR was performed using sense primer labelled by 6-Fam and capillary electrophoresis was carried out in an ABI 3730 DNA analyser. The frequency of the (TA)(7)/(TA)(7) genotype in the control group was estimated at 18.13%, (TA)(6)/(TA)(7) at 45.05% and (TA)(6)/(TA)(6) at 36.26%. There was a statistically significant difference in the (TA)(6)/(TA)(6) genotype distribution between healthy individuals and patients with glucose-6-phosphate dehydrogenase deficiency (p=0.041). Additionally, uncommon genotypes, (TA)(5)/(TA)(6), (TA)(5)/(TA)(7) and (TA)(7)/(TA)(8) of the promoter polymorphism, were discovered. Genotyping of the UGT1A1 gene showed distinct distribution of the common A(TA)(n)TAA polymorphism relative to other European populations. Because of a greater risk of hyperbilirubinaemia due to hereditary haemolytic anaemia, the diagnosis of Gilbert syndrome in this group of patients is very important.

  17. The Beck Depression Inventory II and the Beck Anxiety Inventory in People with Intellectual Disabilities: Factor Analyses and Group Data

    Science.gov (United States)

    Lindsay, William R.; Skene, Danielle D.

    2007-01-01

    Background: There have been several developments in research on emotional disorders in people with intellectual disability (ID). Although a large amount of work has been completed in mainstream clinical fields on the "Beck Anxiety Inventory" (BAI) and the "Beck Depression Inventory"-2nd Edition (BDI-II), to date there has been…

  18. Conversion Matrix Analysis of GaAs HEMT Active Gilbert Cell Mixers

    DEFF Research Database (Denmark)

    Jiang, Chenhui; Johansen, Tom Keinicke; Krozer, Viktor

    2006-01-01

    In this paper, the nonlinear model of the GaAs HEMT active Gilbert cell mixer is investigated. Based on the model, the conversion gain expression of active Gilbert cell mixers is derived theoretically by using conversion matrix analysis method. The expression is verified by harmonic balance...

  19. Replication and Pedagogy in the History of Psychology IV: Patrick and Gilbert (1896) on Sleep Deprivation

    Science.gov (United States)

    Fuchs, Thomas; Burgdorf, Jeffrey

    2008-01-01

    We report an attempted replication of G. T. W. Patrick and J. A. Gilbert's pioneering sleep deprivation experiment "Studies from the psychological laboratory of the University of Iowa. On the effects of loss of sleep", conducted in 1895/96. Patrick and Gilbert's study was the first sleep deprivation experiment of its kind, performed by some of the…

  20. Conversion Matrix Analysis of GaAs HEMT Active Gilbert Cell Mixers

    OpenAIRE

    Jiang, Chenhui; Johansen, Tom Keinicke; Krozer, Viktor

    2006-01-01

    In this paper, the nonlinear model of the GaAs HEMT active Gilbert cell mixer is investigated. Based on the model, the conversion gain expression of active Gilbert cell mixers is derived theoretically by using conversion matrix analysis method. The expression is verified by harmonic balance simulation with Angelov HEMT model in Agilent Advanced Design System (ADS) and by chip measurement results.

  1. Gilbert Rahm and the Status of Mesotardigrada Rahm, 1937.

    Science.gov (United States)

    Grothman, Gary T; Johansson, Carl; Chilton, Glen; Kagoshima, Hiroshi; Tsujimoto, Megumu; Suzuki, Atsushi C

    2017-02-01

    The tardigrade class Mesotardigrada was erected on the basis of the description of Thermozodium esakii by Gilbert Rahm in 1937. In some characteristics, T. esakii is intermediate between members of the classes Eutardigrada and Heterotardigrada. The class Mesotardigrada is known only from Rahm's published drawings of T. esakii; no voucher specimens are known, and subsequent attempts to collect it at the locus typicus have been unsuccessful. Among the possible explanations for this situation are that Rahm may have collected specimens of a more typical tardigrade, but misinterpreted what he saw. Alternatively, changes in habitat in the area may have led to the tardigrade's extirpation. Perhaps T. esakii is a rare species, such that recent sampling efforts have been insufficient to rediscover it. Finally, Rahm's 1937 description may be an attempt at deception. Until physical evidence of T. esakii is found, the species, and by extension the class Mesotardigrada, should be considered nomen dubium.

  2. Gilbert Gottlieb: intermediator between psychology and evolutionary biology.

    Science.gov (United States)

    Rosenblatt, Jay S

    2007-12-01

    This article describes and evaluates Gilbert Gottlieb's role as an intermediator between psychology and evolutionary biology. He proposed that altered developmental conditions gave rise to new behavioral phenotypes (behavioral neophenotypes) that could provide the basis for initiating speciation. As an example, Gottlieb cited sympatric speciation of two species of fruit flies (Rhageletis pomella), which he believed was based on an ontogenetic shift in pupal feeding on apples or hawthorn fruit which determined their adult selection of apple or hawthorn trees for ovipositing. Recent evidence has provided additional links in the process of speciation of these fruit flies. Unlike other efforts to incorporate evolution in psychology, Gottlieb's theoretical contribution was based on actual evolutionary processes including recent developments in the field of evo-devo.

  3. Textual Rhetorics and Textual Carnivals: Susan Miller and the "Subjects" of Rhetoric and Composition.

    Science.gov (United States)

    Reynolds, Nedra

    1991-01-01

    Reviews two books by Susan Miller: "Rescuing the Subject: A Critical Introduction to Rhetoric and the Writer" (1989) and "Textual Carnivals: The Politics of Composition" (1991). Notes how she rereads dominant histories of rhetoric and writing instruction, argues for a theory of textuality, and illustrates how attention to…

  4. Don't Take Touch for Granted: An Interview with Susan Lederman.

    Science.gov (United States)

    Verry, Rene

    1998-01-01

    Presents an interview with Susan Lederman that contains a fascinating and informative overview of the recent developments in neuropsychological research concerning the sense of touch. Discusses the physiological processes that support this sensory experience and reveals them to be much more flexible, intricate, and adaptive than previously…

  5. Re-Establishing Social Studies as a Core Subject: An Interview with Susan Griffin

    Science.gov (United States)

    Griffin, Susan

    2014-01-01

    NCSS Executive Director Susan Griffin was chair of the Task Force of Professional Organizations that worked with the Social Studies Assessment, Curriculum, and Instruction Collaborative (SSACI) of the Council of Chief State School Officers to initiate and guide the development of the "College, Career and Civic Life (C3) Framework for Social…

  6. Teaching Students About Stereotypes, Prejudice, and Discrimination: An Interview with Susan Fiske

    Science.gov (United States)

    Hackney, Amy

    2005-01-01

    Susan T. Fiske is professor of psychology, Princeton University (PhD, Harvard University; honorary doctorate, Universite Catholique de Louvain-la-Neuve, Belgium). She wrote Social Cognition (with Taylor) on how people make sense of each other. Currently, she investigates emotional prejudices (pity, contempt, envy, and pride) at cultural,…

  7. Inside the Sex Ed Studio: An Interview with Susan N. Wilson

    Science.gov (United States)

    Taverner, William J.

    2007-01-01

    "Inside the Sex Ed Studio" profiles leaders in the field of sexuality education. Susan N. Wilson, former Executive Coordinator of the Network for Family Life Education, long-time advocate for sexuality education, and the driving force behind New Jersey's K-12 mandate for comprehensive sexuality education was the first such leader to be…

  8. Beck's Cognitive Therapy: An Overview for Rehabilitation Counselors.

    Science.gov (United States)

    Bowers, Wayne A.

    1988-01-01

    This article introduces Beck's Cognitive Therapy as a counseling model for rehabilitation counselors. The structured approach and success in treating anxiety and depression contribute to its validity as a tool in rehabilitation. (DB)

  9. Kashin-Beck disease and drinking water in Central Tibet

    OpenAIRE

    La Grange, M.; Mathieu, F.; Begaux, F.; Suetens, C.; Durand, M.-Cl.

    2001-01-01

    A cross-sectional survey was carried out in order to study the relationship between Kashin-Beck disease and drinking water. The average volume of the water containers was larger in families unaffected by the disease. Organic material was measured by ultraviolet (UV) spectroscopy. The UV absorbency was significantly lower in drinking water of unaffected families. Thus, the organic material in drinking water may play a role in the pathogenesis of Kashin-Beck disease.

  10. Anestesia em paciente com síndrome de Gilbert: relato de caso Anestesia en paciente con síndrome de Gilbert: relato de caso Anesthesia in a patient with Gilbert's syndrome: case report

    Directory of Open Access Journals (Sweden)

    Fabiano Timbó Barbosa

    2004-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A síndrome de Gilbert é uma doença crônica benigna, a qual leva à icterícia recorrente com grande aumento da bilirrubina não conjugada, que pode levar à toxicidade após o uso de medicações utilizadas na prática diária. O objetivo deste relato é descrever a conduta anestésica em uma paciente com síndrome de Gilbert, submetida à cirurgia videolaparoscópica. RELATO DO CASO: Paciente do sexo feminino, com 22 anos, portadora da síndrome de Gilbert, submetida à cirurgia videolaparoscópica sob anestesia geral com propofol, alfentanil, succinilcolina, atracúrio e isoflurano. Não houve sinais de toxicidade durante a anestesia. A paciente apresentou recuperação pós-operatória sem intercorrências e recebeu alta hospitalar após três dias. CONCLUSÕES: O paciente portador da síndrome de Gilbert pode ser submetido à anestesia geral de forma segura sem o aparecimento de toxicidade desde que sejam evitados os fatores que possam levar à diminuição da atividade da glicuroniltransferase.JUSTIFICATIVA Y OBJETIVOS: La síndrome de Gilbert es una enfermedad crónica benigna la cual lleva a la ictericia recurrente con grande aumento de la bilirrubina no conjugada, que puede llevar a la toxicidad después del uso de medicamentos utilizadas en la práctica diaria. El objetivo de este relato es describir la conducta anestésica en una paciente con síndrome de Gilbert, sometida a cirugía videolaparoscópica. RELATO DEL CASO: Paciente del sexo femenino, con 22 años, portadora de la síndrome de Gilbert fue sometida a cirugía videolaparoscópica bajo anestesia general con propofol, alfentanil, succinilcolina, atracúrio e isoflurano. No hubo señales de toxicidad durante la anestesia. La paciente presentó recuperación pós-operatoria sin intercurrencias y recibió alta hospitalar después de tres días. CONCLUSIONES: El paciente portador del síndrome de Gilbert puede ser sometido a la anestesia general de

  11. Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin: report of two cases

    Directory of Open Access Journals (Sweden)

    Eduardo Flores-Villalba

    2016-04-01

    Full Text Available Gilbert's syndrome is a benign condition characterized by asymptomatic sporadic episodes of jaundice, due to a mild unconjugated hyperbilirubinemia caused by a deficiency in bilirubin glucoronidation. Under certain physiologic or pathologic events, bilirubin level rises but according to literature it does not reach out more than 3 mg/dl. We report 2 cases of Gilbert's syndrome, genetically tested, which presented with bilirubin levels above 6 mg/dl without any trigger or coexisting condition. In conclusion, bilirubin levels higher than 6 mg/dl in Gilbert syndrome are rare, hemolytic and other metabolism diseases must be ruled out, and genetic testing may be necessary in some cases.

  12. [Clinical and pathological features of 16 patients with Gilbert syndrome and 2 cases with genetic analysis].

    Science.gov (United States)

    Peng, Xiang-xin; Wang, Tai-ling

    2008-05-01

    To summarize the clinical and pathological features of Gilbert syndrome. The clinical features and liver histological findings of 16 cases of Gilbert syndrome were reviewed. Of the 16 cases (13 males and 3 females, with an age range from 14 to 40 years), all had recurrent jaundice, unconjugated hyperbilirubinemia and lipofuscin granules in the hepatocytes around the hepatic perivenular areas. The genetic analysis of the two patients showed that the site of genetic mutations were located at exon 1 (Gly71Arg). The diagnosis of Gilbert disease can be improved by combining the data of clinical features, the genetic analysis findings and the histological changes of the livers of the patients.

  13. Unusual presentation of Gilbert disease with high levels of unconjugated bilirubin. Report of two cases.

    Science.gov (United States)

    Flores-Villalba, Eduardo; Rodriguez-Montalvo, Carlos; Bosques-Padilla, Francisco; Arredondo-Saldaña, Gabriela; Zertuche-Maldonado, Tania; Torre-Flores, Landy

    2016-04-01

    Gilbert's syndrome is a benign condition characterized by asymptomatic sporadic episodes of jaundice, due to a mild unconjugated hyperbilirubinemia caused by a deficiency in bilirubin glucoronidation. Under certain physiologic or pathologic events bilirubin level rises but according to literature it does not reach out more than 3 mg/dl. We report 2 cases of Gilbert's syndrome, genetically tested, which presented with bilirubin levels above 6 mg/dl without any trigger or coexisting condition. In conclusion, bilirubin levels higher than 6 mg/dL in Gilbert syndrome are rare, hemolytic and other metabolism diseases must be ruled out, and genetic testing may be necessary in some cases.

  14. Suicide risk screening: Comparing the Beck Depression Inventory-II, Beck Hopelessness Scale, and Psychache Scale in undergraduates.

    Science.gov (United States)

    Troister, Talia; D'Agata, Madeleine T; Holden, Ronald R

    2015-12-01

    The current research evaluates the effectiveness and relative merits of 3 screening measures (the Beck Depression Inventory-II, the Beck Hopelessness Scale, and the Psychache Scale) in evaluating preexisting suicide risk factors for a sample of 7,522 undergraduate students. All measures demonstrated significant diagnostic accuracy for indicating suicide ideation, previous single and multiple suicide attempts, and a recent suicide attempt, which are all serious risk factors for subsequent death by suicide in university students. However, the Psychache Scale displayed superior performance in accurately identifying suicide risk compared with both the Beck Depression Inventory-II and the Beck Hopelessness Scale. Identifying students most at risk for suicide requires diagnostically efficient measures, thus preliminary cut-scores for identifying at-risk students are provided. (c) 2015 APA, all rights reserved).

  15. Coexisting Duchenne Muscular Dystrophy and Gilbert’s Syndrome: A Case Report

    Directory of Open Access Journals (Sweden)

    Faruk Incecik

    2013-08-01

    Full Text Available Gilbert’s syndrome is characterized by unconjugated hyperbilirubinemia. A 5-year-old boy presented to our hospital with mild hyperbilirubinemia. The patient had persistent unconjugated hyperbilirubinemia with high liver enzymes and creatine phosphokinase. Haemolysis was excluded by normal haemoglobin, and reticulocyte count and finally he was diagnosed to have Gilbert’s syndrome. His creatine kinase concentration was 15600 U/l, and he had a deletion in the dystrophin gene. Finally, the patient was diagnosed both Gilbert’s syndrome and Duchenne muscular dystrophy. To our knowledge, this is the first report of the concomitance of Duchenne muscular dystrophy and Gilbert’s syndrome in the literature. [Cukurova Med J 2013; 38(4.000: 791-793

  16. Gilbert Lake Narrative Report : Mark Twain National Wildlife Refuge Complex : 1980

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Mark Twain National Wildlife Refuge summarizes Refuge activities during the 1980 calendar year for the Gilbert Lake Division. The...

  17. Urinary excretion of oxidative metabolites of bilirubin in subjects with Gilbert syndrome.

    Science.gov (United States)

    Vítek, Libor; Kráslová, Ivana; Muchová, Lucie; Novotný, Ladislav; Yamaguchi, Tokio

    2007-06-01

    Bilirubin is a potent endogenous antioxidant substance. Recent data suggest a direct relationship exists between urinary excretion of biopyrrins, a novel group of bilirubin oxidative metabolites, and severity of oxidative stress. The aim of this study was to evaluate urinary excretion of biopyrrins in subjects with Gilbert syndrome. The study included patients with Gilbert syndrome (n = 33) and healthy blood donors (n = 25). In all subjects complete biochemical tests were conducted along with analysis of urinary excretion of biopyrrins. Linear and logistic regression analyses were used for multiple adjustments of possible confounders/modifiers. As expected, high serum bilirubin levels were found in the Gilbert syndrome group as compared to controls (27.8 +/- 9.7 vs 9.9 +/- 3.0 micromol/L, P Gilbert syndrome group as compared to normobilirubinemic control subjects (19.9 +/- 26.0 vs 90.2 +/- 139.1 U/g urinary creatinine, P Gilbert syndrome group also had very low prevalence odds ratios for urinary biopyrrins above the median of the control values even after adjustment for possibly confounding factors (odds ratio 0.18, 95% confidence interval 0.33-0.94; P = 0.042). An inverse relationship was demonstrated between serum bilirubin level and urinary excretion of biopyrrins, which is presumably due to antioxidative effects of elevated serum bilirubin levels in Gilbert syndrome.

  18. Individuation, Cosmogenesis and Technology: Sri Aurobindo and Gilbert Simondon

    Directory of Open Access Journals (Sweden)

    Debashish Banerji

    2015-02-01

    Full Text Available The turn of the 19th/20th centuries saw a number of philosophers of conscious evolution emerging from different cultural backgrounds. This paper argues that this phenomenon, which has sometimes been seen as a philosophical consequence of Darwin’s evolutionary theory in the life sciences, is more importantly related to the enhanced scope of human subjectivity made possible by technology at this time. Yet technology remains the “unthought within the thought” of its times, an ambiguous presence, derided for its alienating effects and praised for its enhancement of human capacities and comforts. A later generation of thinkers, belonging to the post World War II era renews the thought of conscious evolution, now in engagement with new technologies of a planet spanning scope. This essay considers the ideas of these two generations of thinkers, focusing on Sri Aurobindo (1872-1950 from the earlier generation and Gilbert Simondon (1924-1989 from the more recent era, questioning the consequences of contemporary technology in their thoughts, goals and practices. In developing the historical continuity of ideas, it tracks the question of technology from the earlier to the later generation, highlighting the understanding of both its promise and its ills and engaging with it the possibilities of conscious evolution.

  19. Some psychometric characteristics of the Beck's Hopelessness Scale

    Directory of Open Access Journals (Sweden)

    Novović Zdenka

    2005-01-01

    Full Text Available The study tested reliability and construct validity of Serbian translation of Beck's Hopelessness scale on a sample of patients diagnosed as a depressive, anxious and anxious-depressive disorder. Scale was found to have a high degree of internal consistency (Cronbach alpha = 0.91. Principal component analysis, with Scree-test as the criterion of extraction, provided single factor as the best solution. Hopelessness Scale highly correlated with symptoms of depression, low self-concept and depressive automatic thoughts which the authors interpreted as the confirmation of Beck's theory. The hypothesis that hopelessness is construct specific to depression and not to anxiety is, also, confirmed.

  20. Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome.

    Science.gov (United States)

    Maruhashi, Tatsuya; Soga, Junko; Fujimura, Noritaka; Idei, Naomi; Mikami, Shinsuke; Iwamoto, Yumiko; Kajikawa, Masato; Matsumoto, Takeshi; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Tomiyama, Hirofumi; Takase, Bonpei; Yamashina, Akira; Higashi, Yukihito

    2012-07-31

    Patients with Gilbert syndrome have mild unconjugated hyperbilirubinemia. It has been shown that bilirubin is an endogenous antioxidant. We evaluated the role of oxidative stress in endothelial function in patients with Gilbert syndrome under normal conditions without cardiovascular risk factors. A total of 108 young men with Gilbert syndrome without cardiovascular risk factors and 108 age-matched healthy men (normal controls) were enrolled in this study. Serum concentrations of bilirubin were higher in patients with Gilbert syndrome than in control subjects (29.2±11.6 versus 9.4±2.7 μmol/L; PGilbert syndrome than in control subjects (61.8±24.5 versus 72.5±21.8 U/L, P=0.034; 7.8±2.4 versus 10.4±3.2 ng/mg creatinine, P=0.001, respectively). Flow-mediated vasodilation was greater in patients with Gilbert syndrome than in normal control subjects (7.2±2.2% versus 5.9±1.7%; PGilbert syndrome but not in control subjects. In addition, serum concentration of bilirubin correlated with malondialdehyde-modified low-density lipoprotein (r=-0.20, P=0.04) and 8-OHdG (r=-0.21, P=0.02) in patients with Gilbert syndrome but not in control subjects. Patients with Gilbert syndrome had low levels of oxidative stress associated with hyperbilirubinemia and enhancement of endothelium-dependent vasodilation. URL: http://www.umin.ac.jp. Unique identifier: UMIN000003409.

  1. LA ESPIRITUALIDAD EN LA OBRA DE GILBERT SIMONDON

    Directory of Open Access Journals (Sweden)

    María de Lourdes Solís Plancarte

    2013-06-01

    Full Text Available El objetivo de este artículo es presentar el tema de la espiritualidad, una de las tesis más polémicas dentro del pensamiento de Gilbert Simondon. Planteamos la espiritualidad a partir de  la obra más conocida de Simondon, El modo de existencia de los objetos técnicos (MEOT, así como de la última parte de su obra capital La individuación a la luz de las nociones de forma e información (ILFI, junto con el curso Imagination et invention. Se argumenta que la espiritualidad emerge de la relación del individuo con otros individuos y con el mundo, es decir, la transindividualidad, fase que atraviesa la composición de un sistema de relaciones que se extiende más allá de la percepción humana, bajo la forma de puntos claves. En otras palabras, intentamos mostrar cierto vínculo entre lo transindividual en ILFI y los puntos-clave en MEOT. El artículo ofrece una breve introducción al autor y su obra,  describe el sistema afectivo-emotivo que Jung descubrió en su análisis del subconsciente, para abordar el tema de la espiritualidad bajo la égida del mundo mágico primitivo, realizado a través de ciertos enfoques Mircea Eliade. El plano de la cultura es discutido desde la individuación psíquica colectiva.

  2. Brief Report Reliability of the Beck Depression Inventory and the ...

    African Journals Online (AJOL)

    Brief Report Reliability of the Beck Depression Inventory and the Self-Rating Anxiety Scale in a sample of South African adolescents. ... Anxiety Scale for epidemiological investigations of adolescents' symptoms. Method — Self-report questionnaires were administered on two ... Future studies should include larger and more ...

  3. Cholera, canals, and contagion: Rediscovering Dr. Beck's report.

    Science.gov (United States)

    Tuite, Ashleigh R; Chan, Christina H; Fisman, David N

    2011-08-01

    Cholera first appeared in North America (in Montreal and Quebec) in 1832 and spread rapidly across the eastern half of the continent. The dispatch of American disease control experts to Lower Canada in anticipation of cholera's spread implies that medical professionals expected spread, possibly from contagion, even though the notion that cholera was contagious was disparaged in medical writings of the time, and would be until John Snow's landmark work in London in the 1850s. Snow's insights derived largely from his observations on spatial and temporal patterns of cholera cases. We discuss a document from the 1832 epidemic, the report of Dr. Lewis Beck to New York's Governor Throop, which anticipates Snow in presenting geospatial data that imply cholera's contagiousness. Beck shows that the movements of immigrants along the newly completed New York state canal system resulted in sequential cholera outbreaks along the canal's path. Although aware of the degree to which this suggested contagion, Beck argues strenuously against the contagiousness of cholera. We explore the social context of early nineteenth-century medicine that probably led Beck to disbelieve his own observations, and to favor a medical model inconsistent with his data. Themes that emerge from our inquiry include belief in disease as a physical manifestation of defective morality, stigmatization of the poor and immigrant groups, and reluctance to overturn prevailing medical models that themselves reflected the economic position of medical practitioners. We show that these themes continue to serve as obstacles to innovation in medical and public health practice today.

  4. Increased prevalence of cholelithiasis in Gaucher disease: association with splenectomy but not with gilbert syndrome.

    Science.gov (United States)

    Ben Harosh-Katz, Miriam; Patlas, Michael; Hadas-Halpern, Irith; Zimran, Ari; Elstein, Deborah

    2004-08-01

    The purpose of this study is to ascertain the incidence of gallstones among adult patients with type 1 Gaucher disease and whether the presence of the UDPGT1 polymorphism (Gilbert syndrome), increases the incidence of gallstones. Cholelithiasis was been observed among patients with type I Gaucher disease with variable frequency. Too, studies have addressed the possibility of an association between Gilbert syndrome and formation of bilirubinate gallstones in hereditary spherocytosis wherein, like Gaucher disease, there is hemolysis of blood cell membranes. Medical records of all adult patients with type 1 disease in a referral clinic were reviewed for evidence of gallstones or cholecystectomy. Blood samples were collected for molecular analysis for Gilbert syndrome. Of 323 adult patients, 82 patients (25.4%), 54 women (65.9%) and 28 men (34.1%), had evidence of gallbladder disease (P Gilbert syndrome (P = 0.002). This study highlights an increase incidence of cholelithiasis but not Gilbert syndrome among patients with Gaucher disease. Storage of glycolipid per se or an immune reaction to storage, may explain these findings.

  5. [Prevalence of Gilbert syndrome and its genetic determinants in Chile].

    Science.gov (United States)

    Méndez, Luis; Lagoa, Marcela; Quiroga, Teresa; Margozzini, Paula; Azócar, Lorena; Molina, Héctor R; Vera, Alejandra; Villarroel, Luis; Arrese, Marco; Hampe, Jochen; Buch, Stephan; Miquel, Juan F

    2013-10-01

    In Europeans the TATA box TA7 repeat promoter variant in the UGT1A1 gene (UGT1A1*28) is the major determinant of bilirubin levels. To study the prevalence of Gilbert Syndrome (GS) and its genetic determinants in Chile. Three different studies were conducted. The prevalence of GS in Chile was assessed in 991 subjects with normal liver tests (ALT and GGT) from the 2nd National Health Survey. We defined GS as a total bilirubin (TB) between 1.4-5mg/dL. The second study assessed the genotype prevalence of SNP rs6742078 (in LD with UGT1A1*28) and rs4149056 in 500 DNA samples of non-related Hispanics. Finally, a case-control study was designed to assess the phenotype-genotype correlation. UGT1A1*28 and rs4149056 variants were determined by direct sequencing and allelic discrimination assays (TaqMan), respectively. Prevalence of GS in the general Chilean population was 2.6% (4.5% in males and 0.5% in female). No correlation with age, educational level or home location was found. Genotypes for UGT1A1*28 (TA6/6 50.5%, TA6/7 37.8%, TA7/7 11.7%) and rs4149056 (TT 74.1%, CT 22.8%, and CC 3.1%) variants were similar to Europeans. In the case-control study, most patients with GS were homozygotes for UGT1A1*28 (TA7/7, 74%). Of note, 44% of patients with intermediate TB levels were also TA7/7, compared to 7% in normal subjects. SLCO1B1 genotype was not correlated with TB levels. While the prevalence of GS was lower in Chile compared to Europeans (~5%), the prevalence of UGT1A1*28 homozygotes was similar (~12%). In Chilean Hispanics, the UGT1A1*28 variant explain 75% of GS phenotype.

  6. Aaron Temkin Beck (born July 18, 1921- Biography

    Directory of Open Access Journals (Sweden)

    K. Fatih Yavuz

    2012-08-01

    Full Text Available Aaron Beck was born in Providence, Rhode Island, USA, the youngest child of four siblings. Beck attended Brown University, graduating magna cum laude in 1942. Then he attended Yale Medical School, graduating with an M.D. in 1946. After his graduation, he served a rotating internship, followed by a residency in pathology at the Rhode Island Hospital. Although initially not interested in psychiatry, a residency in neurology at the Cushing Veterans Administration Hospital in Framingham, MA, required rotation in psychiatry intrigued him with some of the more recent developments in the field. He spent two years as a fellow at Austin Riggs Center at Stockbridge where he acquired substantial experience in conducting longterm psychotherapy. The Korean War shifted Beck’s area of work to the Valley Forge Army Hospital where he was Assistant Chief of Neuropsychiatry. Dr. Beck joined the Department of Psychiatry of the University of Pennsylvania in 1954. He initially conducted research into the psychoanalytic theories of depression. He developed a different theoretical-clinical approach that he labelled cognitive therapy. Since 1959 he has directed funded research investigations of the psychopathology of depression, suicide, anxiety disorders, panic disorders, alcoholism, drug abuse, personality disorders, and schizophrenia and of cognitive therapy of these disorders. Currently Aaron T. Beck, M.D., is the President Emeritus of the non-profit Beck Institute for Cognitive Therapy and Research, and University Professor in the Department of Psychiatry at the University of Pennsylvania and the director of the Psychopathology Research Unit (PRU, which is the parent organization of the Center for the treatment and Prevention of Suicide. He has published more than 550 scholarly articles and 18 books and has developed widely used assessment scales. He has received many prestigious awards including the 2006 Albert Lasker Clinical Medical Research Award for

  7. Role of UGT1A1 gene polymorphism in the pathogenesis of Gilbert syndrome

    Directory of Open Access Journals (Sweden)

    SONG Jinyun

    2016-03-01

    Full Text Available As a bilirubin metabolic disorder, Gilbert syndrome belongs to the category of congenital non-hemolytic jaundice. Deficiency or decrease in the activity of bilirubin-uridine diphosphate glucuronyltransferase (UGT is an important reason for the pathogenesis of Gilbert syndrome. UGT1A1, an isoenzyme of UGT, is a key enzyme to direct bilirubin in the liver. Mutations in UGT1A1 gene lead to the structural abnormality of UGT, and thus result in the decrease or loss of the ability of UGT to bind bilirubin. This article summarizes the research advances in the role of UGTA1 and its polymorphism in the pathogenesis and diagnosis of Gilbert syndrome.

  8. Coexistence of gilbert syndrome and hereditary spherocytosis in a child presenting with extreme jaundice.

    Science.gov (United States)

    Lee, Jae Hee; Moon, Kyung Rye

    2014-12-01

    Gilbert syndrome is the most common inherited disorder of bilirubin glucuronidation. It is characterized by intermittent episodes of jaundice in the absence of hepatocellular disease or hemolysis. Hereditary spherocytosis is the most common inherited hemolytic anemia and is characterized by spherical, osmotically fragile erythrocytes that are selectively trapped by the spleen. The patients have variable degrees of anemia, jaundice, and splenomegaly. Hereditary spherocytosis usually leads to mild-to-moderate elevation of serum bilirubin levels. Severe hyperbilirubinemia compared with the degree of hemolysis should be lead to suspicion of additional clinical conditions such as Gilbert syndrome or thalassemia. We present the case of a 12-year-old boy with extreme jaundice and nausea. The diagnosis of hereditary spherocytosis was confirmed by osmotic fragility test results and that of Gilbert syndrome by genetic analysis findings.

  9. Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome).

    Science.gov (United States)

    Strassburg, Christian P

    2010-10-01

    Hyperbilirubinemia is an important clinical sign that often indicates severe hepatobiliary disease of different etiologies. Inherited non-haemolytichyperbilirubinemic conditions include Dubin-Johnson, Rotor, and Gilbert-Meulengracht syndromes, which are important differential diagnoses indicating benign disease that require no immediate treatment. Dubin-Johnson and Rotor syndromes are rare, exhibit mixed direct and indirect hyperbilirubinemia as well as typical profiles or urinary coproporphyrin excretion. Gilbert-Meulengracht disease leads to unconjugated hyperbilirubinemia because of impaired glucuronidation activity, and is part of a spectrum of genetic variants also encompassing fatal Crigler-Najjar syndrome. Gilbert-Meulengracht syndrome can be diagnosed by clinical presentation, biochemistry and genotyping, and carries significance regarding the disposition towards drug-associated toxicity. In addition, the precise diagnosis of these inherited hyperbilirubinemic syndromes avoids unnecessary invasive procedures for suspected more severe hepatobiliary disease. Copyright © 2010 Elsevier Ltd. All rights reserved.

  10. [Clinical Characteristics and Gene Mutations of Gilbert Syndrome Complicated with Myeloproliferative Neoplasm].

    Science.gov (United States)

    Li, Xing-Xin; Shi, Jun; Huang, Zhen-Dong; Shao, Ying-Qi; Nie, Neng; Zhang, Jing; Ge, Mei-Li; Huang, Jin-Bo; Zheng, Yi-Zhou

    2017-04-01

    To investigate the clinical characteristics and gene mutations of patients with Gilbert syndrome complicated with myeloproliferative neoplasms (MPN). Peripheral blood samples from 1 patient with Gilbert syndrome complicated with MPN and his son were collected to analyse all exon mutations of UGT1A1 gene. The patient with leukocytosis, thrombocythemia, mild anemia and positive JAK2/V617F mutation was initially diagnosed as MPN. The hyperbilirubinemia suggested concurrent disease. Further gene evaluation disclosed a insertion mutation in the (TA)6TAA box, and a missense mutation(G→A) at 211 bp of exon 1, corresponding to the deficiency in the bilirubin-conjugating enzyme uridine-diphosphoglucuronosyl transferase1A1 (UGT1A1). His son only carried some polymorphism mutation without manifestation of this disease. It is a first report case of MPN complicated with Gilbert syndrome that can highlight the differential diagnosis for hyperbilirubinemia.

  11. Gilbert Syndrome with Concomitant Hereditary Spherocytosis Presenting with Moderate Unconjugated Hyperbilirubinemia.

    Science.gov (United States)

    Aiso, Mitsuhiko; Yagi, Minami; Tanaka, Atsushi; Miura, Kotaro; Miura, Ryo; Arizumi, Toshihiko; Takamori, Yoriyuki; Nakahara, Sayuri; Maruo, Yoshihiro; Takikawa, Hajime

    2017-01-01

    We experienced a case of a 19-year-old man with Gilbert syndrome with concomitant hereditary spherocytosis. The patient presented with moderate unconjugated hyperbilirubinemia, and inherited etiology was strongly suspected. The diagnosis of Gilbert syndrome was confirmed by the genetic analysis of the UGT1A1 gene, demonstrating UGT1A1*28 and compound heterozygote UGT1A1*6. In addition, since the laboratory findings and imaging studies revealed lysemia as well as gallstone and splenomegaly, a diagnosis of hereditary spherocytosis was made as a comorbidity. Both Gilbert syndrome and hereditary spherocytosis are hereditary diseases with a high frequency, and the hyperbilirubinemia may be exacerbated when these two diseases are concomitant.

  12. Hepatotoxicity of isotretinoin in patients with acne and Gilbert's syndrome: a comparative study

    Science.gov (United States)

    Fernández-Crehuet, Pablo; Fernández-Crehuet, José Luis; Allam, Mohamed Farouk; Fernández-Crehuet Navajas, Rafael

    2014-01-01

    Objectives The objective of our follow-up study is to evaluate liver function tests (LFTs) and lipid profiles in patients with Gilbert's syndrome treated with isotretinoin because of severe acne. Setting Dermatology outpatient clinics of three regional hospitals of Jaén (Spain). Participants Over 4 years, we included all patients diagnosed with severe acne. Only 37 patients were identified, of which 11 had Gilbert's syndrome. Interventions All patients were treated with isotretinoin and followed-up in our outpatient clinics after 10 and 20 weeks. Patients were subjected to an interview questionnaire which included data on age, gender, complete blood count, coagulation profile, fasting blood glucose, LFTs and lipid profiles. Data and results of patients with severe acne and Gilbert's syndrome were compared with those of 26 patients with only severe acne (control group). Primary outcome Blood analyses were repeated in the follow-up visits. Results In patients with Gilbert's syndrome, bilirubin levels showed substantial decrease over the 20-week follow-up, with more decrease after 10 weeks. None of the control group patients had significant increase in total bilirubin levels after 10 and 20 weeks of follow-up. Liver enzymes were maintained within normal levels in both groups. Both study groups did not show significant pathological increase in lipid profile levels. LDL levels were increased in the two study groups, but this increase was less substantial in patients with Gilbert's syndrome. Conclusions Our preliminary results suggest that oral isotretinoin could be an effective, safe treatment for patients with Gilbert's syndrome, and may lower bilirubin levels in the first 10 weeks of treatment. Limitations of the study include the small numbers of participants and the fact that it is restricted to one region of Spain. PMID:24650805

  13. Cognitiva (TC de Beck en una muestra costarricense

    Directory of Open Access Journals (Sweden)

    Hannia Cabezas Pizarro

    2006-01-01

    Full Text Available En este estudio se explora una posible relación empírica entre la terapia racional emotivoconductual (TREC de Ellis y la terapia cognitiva (TC de Beck, dos de los modelos más conspicuos en el campo de la psicoterapia cognitiva actual. Si bien este modelo utiliza el término “cognitivo” en forma tal que se encuentra asociado con el afecto, la fisiología y la conducta (Dobson, 1986, sostiene que las perturbaciones emocionales, en esencia, son causadas por el proceso cognitivo del individuo. En esta investigación, se trabajó con una muestra de 200 estudiantes de la Universidad de Costa Rica de diferentes áreas a quienes se les aplicaron las escalas de: Attitudes and Beliefs Inventory (ABI [Escala de Actitudes y Creencias], y el Beck Depression Inventory, 2ª edición (BDI-II [Inventario de Depresión de Beck], escalas que fueron adaptadas al español. El análisis estadístico de los datos confirma empíricamente la relación entre ambos modelos.

  14. Beck Hopelessness Scale: exploring its dimensionality in patients with schizophrenia.

    Science.gov (United States)

    Kao, Yu-Chen; Liu, Yia-Ping; Lu, Chien-Wen

    2012-06-01

    Hopelessness is a pre-eminent risk factor for suicide and non-fatal self-harm. Although the Beck Hopelessness Scale is often used for schizophrenia, its factor structure has been given relatively little consideration in this context. This study aimed to examine the reliability and validity of the Taiwanese version of the Beck Hopelessness Scale (BHS-T) in a chronic schizophrenia out-patient sample. One hundred and two (102) outpatients were evaluated using the translated Taiwanese version of the BHS (BHS-T), as well as several Beck-related symptom rating scales and the Positive and Negative Syndrome Scale (PANSS) for psycho-pathology. The patients were also evaluated for suicidal intent using the critical items of the Scale for Suicide Ideation (SSI) and suicide attempts. The psychometric properties of the BHS-T were also evaluated, including construct validity, internal consistency, test-retest reliability, convergence, and discriminative validity. The BHS-T showed good overall reliability and stability over time. This translated scale comprised a two-factor solution corresponding negative expectation and loss of motivation dimensions. Differences in mean hopelessness scores between participants with and without suicidal intent were significant. The results also indicated that, among individuals with schizophrenia, "negative expectation in the future" is more closely linked to suicide intent than "loss of motivation for the future". The BHS-T is a reliable and valid instrument for measuring the multi-dimensionality of hopelessness and may complement clinical suicidal risk assessments in individuals with schizophrenia.

  15. "A hint of it, with initials": adultery, textuality and publicity in Jane Austen's Lady Susan.

    Science.gov (United States)

    Russell, Gillian

    2010-01-01

    In spite of Jane Austen's professed “eye” for an adulteress, comparatively little attention has been paid to adultery and divorce as themes and contexts of her fiction. Her unpublished epistolary novel Lady Susan has a distinctive status in Austen's oeuvre, recognized as being exemplary of her “style” and yet atypical of her later achievement. A neglected context for the novel is the extensive reporting of adultery trials in contemporary print culture and the moral panic concerning adultery in the 1780s and 1790s, focusing initially on the adulteress as the brazen woman of fashion and later as a figure of sentimentalized abjection. A particularly notorious case, that involving Lady Henrietta Grosvenor and George III's brother, the Duke of Cumberland, is directly alluded to in Lady Susan. The textual strategies of adultery trial literature, particularly its emphasis on indirection through the use of detail or “hint”, had a long-term influence on the development of Austen's fiction and her positioning of herself as a professional writer after the 1790s.

  16. Psychometric Properties of the Beck Depression Inventory for Youth in a Sample of Girls

    Science.gov (United States)

    Stapleton, Laura M.; Sander, Janay B.; Stark, Kevin D.

    2007-01-01

    A new measure has been developed to assess depressive symptoms, the Beck Depression Inventory for Youth (BDI-Y; J. S. Beck, A. T. Beck, & J. B. Jolly, 2001). This research extends previous validation research of BDI-Y total scores by examining internal consistency and convergent and predictive validity within a school-based sample (n = 859) of…

  17. Galvanomagnetic transport properties and Gilbert damping in ferromagnetic PdCo alloy

    Czech Academy of Sciences Publication Activity Database

    Kudrnovský, Josef; Drchal, Václav; Turek, I.

    2017-01-01

    Roč. 30, č. 5 (2017), s. 1367-1370 ISSN 1557-1939 R&D Projects: GA ČR GA15-13436S Institutional support: RVO:68378271 Keywords : anomalous Hall effect * Gilbert damping * partial order * first-principles Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.180, year: 2016

  18. Insect-plant coevolution in the mountains of Sinai | Gilbert | Egyptian ...

    African Journals Online (AJOL)

    Insect-plant coevolution in the mountains of Sinai. Francis Gilbert, Samy Zalat, Fayez Semida. Abstract. Egyptian Journal of Biology Vol.1 1999: 142-152. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL.

  19. [The prevalence of hyperbilirubinaemia and the diagnostics of Gilbert-syndrome in our work fitness examinations].

    Science.gov (United States)

    Soós, Pál

    2007-11-11

    The Gilbert-syndrome is a mild metabolism anomaly, which is spread all over the world. Every twentieth person is affected in the general population. We examined 1307 people in MH EVI at expedient operated specialist' workplaces, where we investigate work capacity evaluation in the first three months of 2006. Estimating the laboratory results, the frequent increases of total bilirubin plasma levels were remarkable, which we observed in 117 cases. Our control examinations pointed out that in 57 cases of the 117 the increase was caused by the accumulation of indirect unconjugated bilirubin. In theses cases, aimed examinations indicated neither hepatic disease nor any disease with increased hemolysis. Therefore, lack of other diagnostic sign, the abnormal value led to the diagnosis of Gilbert-syndrome. In respect of physical loading capacity, there is no united stand in the judging of Gilbert-syndrome. Therefore we made a comparison between the results of 57 patients with Gilbert-syndrome and of 57 healthy controls with the same age and gender. We made this examination in our institute, at the department which investigates the fitness for physical activity. We didn't notice any difference between the two groups' loading capacity. In consequence of our study and of other observations till now, we should re-interpret the question of restriction in the field of work. Our observations refer to a representative group. We hope this study will help in diagnostic considerations and in the correct general estimation of the importance of this metabolic anomaly.

  20. [From gene to disease; unconjugated hyperbilirubinemia: Gilbert's syndrome and Crigler-Najjar types I and II

    NARCIS (Netherlands)

    Drenth, J.P.H.; Peters, W.H.M.; Jansen, J.B.M.J.

    2002-01-01

    Gilbert's syndrome consists of a mild unconjugated hyperbilirubinemia occurring in the absence of liver disease or haemolysis. Total plasma bilirubin can be as high as 80 mumol/l and mild intermittent jaundice does occur. The inheritance pattern is probably autosomal recessive. It has been estimated

  1. Gilbert syndrome increasing unconjugated hyperbilirubinemia in a child with hereditary spherocytosis.

    Science.gov (United States)

    Kumar, Dipti; Parakh, Ankit; Sharma, Sunita

    2012-01-01

    Hemolytic anemia usually gives rise to only a modest elevation of serum bilirubin. Unconjugated hyperbilirubinemia of an extreme degree should raise suspicion of additional factors. We describe a 10-year-old child suffering from hereditary spherocytosis, who had unusually high levels of unconjugated serum bilirubin and was diagnosed to have Gilbert syndrome on the basis of genetic analysis.

  2. Autogenic cyclicity of foreset sorting in experimental Gilbert-type deltas

    NARCIS (Netherlands)

    Kleinhans, M.G.

    2005-01-01

    Gilbert-type deltas are commonly characterised by steep foreset bedding. Changes in the foreset characteristics such as grain size, grading, alternating sand and gravel are often interpreted as records of changes of base level or sediment input due to diurnal, seasonal or climatic forcing. To aid

  3. An Interpretation of Part of Gilbert Gottlieb's Legacy: Developmental Systems Theory Contra Developmental Behavior Genetics

    Science.gov (United States)

    Molenaar, Peter C. M.

    2015-01-01

    The main theme of this paper concerns the persistent critique of Gilbert Gottlieb on developmental behavior genetics and my reactions to this critique, the latter changing from rejection to complete acceptation. Concise characterizations of developmental behavior genetics, developmental systems theory (to which Gottlieb made essential…

  4. A generalisation of the Gilbert-Varshamov bound and its asymptotic evaluation

    NARCIS (Netherlands)

    Tolhuizen, L.M.G.

    2011-01-01

    We generalize the Gilbert-Varshamov lower bound on the maximum sizeof a code with given minimum Hamming distance. By using the Delsarteinequalities, it is shown that no improvement is obtained in the asymptotic case. A further improvement is given as well; it is undecided if this improvement can

  5. Adaptation of the Beck Hopelessness Scale in Hungary

    Directory of Open Access Journals (Sweden)

    Sándor Rózsa

    2010-12-01

    Full Text Available Hopelessness Scale (BHS developed by Aaron Beck is an internationally accepted measure in the prediction of suicide. Our study focusssed on the adaptation of the scale in Hungary and its psychometric analysis. From the 1950s Hungary has always been among the top ten countries with the highest suicide rates in the world therefore a valid and reliable measure as a screening instrument in suicide prevention has utmost importance. Three different Hungarian samples (depressed patients with and without suicide attempt as well as control subjects participated in the research. Results showed that the Hungarian version of BHS is a valid and reliable measure.

  6. In the postmodern mirror: intertextuality in Angels and Insects by Antonia Susan Byatt

    Directory of Open Access Journals (Sweden)

    Buda Agata

    2015-05-01

    Full Text Available The aim of the paper is to analyse the novel Angels and Insects by Antonia Susan Byatt in terms of intertextual references. The author’s assumptions are based on the categorisation by Ryszard Nycz, who distinguishes three major types of intertexts: text versus text, text versus literary genre and text versus mimesis. Byatt uses intertextuality mainly to comment on the role of nature in the world, as well as to enhance the importance of human relationship with nature. Moreover, the writer moves towards literary criticism, discussing poems by famous artists, such as Alfred Tennyson or John Milton. In this way, the novel by Byatt is also an example of metafiction. All the narration techniques used by the English writer make the novel a typically postmodern work of art.

  7. Intermittent large amplitude internal waves observed in Port Susan, Puget Sound

    Science.gov (United States)

    Harris, J. C.; Decker, L.

    2017-07-01

    A previously unreported internal tidal bore, which evolves into solitary internal wave packets, was observed in Port Susan, Puget Sound, and the timing, speed, and amplitude of the waves were measured by CTD and visual observation. Acoustic Doppler current profiler (ADCP) measurements were attempted, but unsuccessful. The waves appear to be generated with the ebb flow along the tidal flats of the Stillaguamish River, and the speed and width of the resulting waves can be predicted from second-order KdV theory. Their eventual dissipation may contribute significantly to surface mixing locally, particularly in comparison with the local dissipation due to the tides. Visually the waves appear in fair weather as a strong foam front, which is less visible the farther they propagate.

  8. (REREADING INDEX CARDS: THE ARCHIVIST AS INTERPRETER IN SUSAN PUI SAN LOK'S 'NEWS'

    Directory of Open Access Journals (Sweden)

    Sandra Camacho

    2018-01-01

    Full Text Available Looking at susan pui san lok's projects News (2005 and RoCH (2013, this paper contemplates the notions put forward by Michel-Rolph Trouillot and Jacques Derrida on the power of archivists, not solely as guardians of documents but also as their interpreters. Taking into consideration that photographic and moving image archives present unique difficulties in their cataloguing processes, I examine silences that might be generated by a thematic classification that is not impervious to archivists' biases. Moreover, I consider if the silences created by manual processes of classification and retrieval might be surpassed through digital technologies, or if it is possible that new technologies simply create different types of silencing.

  9. "I Am Not a Fairy Tale": Contextualizing Sioux Spirituality and Story Traditions in Susan Power's "The Grass Dancer"

    Science.gov (United States)

    Diana, Vanessa Holford

    2009-01-01

    Standing Rock Sioux writer Susan Power's best-selling novel "The Grass Dancer" (1994) includes depictions of the supernatural and spiritual that do not conform to the Judeo-Christian or, in some cases, the atheist or rationalist worldviews of many readers. Power writes of ghost characters and haunted places, communication between the living and…

  10. 78 FR 75676 - Mark W. Dobronski and Susan K. Dobronski-Acquisition of Control Exemption-Adrian & Blissfield...

    Science.gov (United States)

    2013-12-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Mark W. Dobronski and Susan K. Dobronski--Acquisition of Control Exemption... Company, Lapeer Industrial Railroad Company and Jackson & Lansing Railroad Company Mark W. Dobronski and...

  11. Satire politique et sociale dans les opérettes de Gilbert et Sullivan Political and Social Satire in Gilbert and Sullivan’s Operettas

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    Anita Cornic

    2009-11-01

    Full Text Available Although Gilbert and Sullivan’s Operas were first and foremost light, humorous works devised to entertain their mostly middle-class audience, they are characterised by a certain amount of political and social satire, as this paper aims to show through telling examples. Beyond the merry and pleasant songs which remain part and parcel of the English cultural heritage, the shafts directed against the social and political institutions (especially the House of Lords and the class system have lost none of their piquancy and even relevance for today’s audience.

  12. THE GENETIC-BASIS OF THE REDUCED EXPRESSION OF BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE-1 IN GILBERTS-SYNDROME

    NARCIS (Netherlands)

    CHOWDHURY, [No Value; GANTLA, S; DEBOER, A; OOSTRA, BA; LINDHOUT, D; TYTGAT, GNJ; JANSEN, PLM; ELFERINK, RPJO; CHOWDHURY, NR

    1995-01-01

    Background. People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia in the absence of liver disease or overt hemolysis. Hepatic glucuronidating activity, essential for efficient biliary excretion of bilirubin, is reduced to about 30 percent of normal. Methods. We sequenced

  13. Bilirubin and beyond : A review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection

    NARCIS (Netherlands)

    Bulmer, A. C.; Verkade, H. J.; Wagner, K. -H.

    Gilbert's syndrome (GS) is characterized by a benign, mildly elevated bilirubin concentration in the blood. Recent reports show clear protection from cardiovascular disease in this population. Protection of lipids, proteins and other macromolecules from oxidation by bilirubin represents the most

  14. Effects of field annealing on Gilbert damping of polycrystalline CoFe thin films

    Science.gov (United States)

    Zhou, Jing; Chen, Shaohai; Lin, Weinan; Qin, Qing; Liu, Liang; He, Shikun; Chen, Jingsheng

    2017-11-01

    The effects of annealing and magnetic field annealing on the Gilbert damping constant of polycrystalline CoFe thin films were investigated. Angle dependent ferromagnetic resonance (FMR) demonstrates that an in-plane (IP) anisotropy is developed by field annealing which dramatically reduces the effective Gilbert damping constant. An inverse relation between effective IP anisotropic field and effective damping is shown by FMR measurement in cryogenic environment. This relation is further confirmed in bilayer films of IrMn/CoFe where a strong in-plane unidirectional anisotropy is developed. A large effective IP anisotropic field is possibly associated with a smaller distribution of local fields which reduces the FMR linewidths and subsequently effective damping.

  15. Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg?

    Science.gov (United States)

    Strassburg, Christian P

    2010-02-01

    Gilbert's syndrome is characterized by mild unconjugated nonhemolytic hyperbilirubinemia, without hepatic inflammation, fibrosis, chronic liver disease, or liver failure. It is readily diagnosed by genetic variants of the UGT1A1 gene, mainly UGT1A1*28, and is also associated with abnormalities of hepatobiliary transport and additional UGT1A gene variants. Apart from representing a potential risk factor in irinotecan and protease inhibitor therapy, it appears to exert protective effects in Hodgkin's lymphoma and cardiovascular disease. Gilbert's syndrome is part of a continuous spectrum of altered glucuronidation that extends to fatal Crigler-najjar disease. The complexity hidden behind this pharmacogenetic abnormality is of profound significance for drug development and therapy.

  16. Severe jaundice in two children with Kawasaki disease: a possible association with Gilbert syndrome.

    Science.gov (United States)

    Karpathios, Themistocles; Moustaki, Maria; Yiallouros, Panagiotis; Sharifi, Fariba; Attilakos, Achilleas; Papadopoulou, Anna; Fretzayas, Andrew

    2012-01-01

    Kawasaki disease is a systemic vasculitis, mainly encountered in children. It may affect any organ. Acute cholestasis and severe obstructive jaundice is an atypical manifestation of the disease. We herein present two children with Kawasaki disease and severe direct hypebilibirunemia who also were homozygous and heterozygous respectively for the (TA)(7) promoter polymorphism of Gilbert syndrome. Intravenous immunoglobulin was administered to both patients at the acute phase of the disease and the fever remitted within 24 hr following the immunoglobulin administration. Furthermore oral aspirin at a dose of 80-100 mg/kg/24 hr was also given. The first child did not develop any coronary ectasia or aneurysm, whereas dilation of the right coronary artery was identified in the second child, one month after the disease onset. We discuss the possible contribution of Gilbert syndrome to the development of jaundice in our patients.

  17. Thermokinetic approach of the generalized Landau-Lifshitz-Gilbert equation with spin polarized current

    OpenAIRE

    Wegrowe, J. -E.

    2000-01-01

    In order to describe the recently observed effect of current induced magnetization reversal in magnetic nanostructures, the thermokinetic theory is applied to a metallic ferromagnet in contact with a reservoir of spin polarized conduction electrons. The spin flip relaxation of the conduction electrons is described thermodynamically as a chemical reaction. The diffusion equation of the chemical potential (or the giant magnetoresistance) and the usual Landau-Lifshitz-Gilbert (LLG) equation are ...

  18. Role of co-inherited Gilbert syndrome on hyperbilirubinemia in Indian beta thalassemia patients.

    Science.gov (United States)

    Dabke, Pooja S; Colah, Roshan B; Ghosh, Kanjaksha K; Nadkarni, Anita H

    2014-10-01

    Gilbert syndrome is characterized by mild unconjugated hyperbilirubinemia. The high levels of bilirubin could be related to the co-inheritance of Gilbert syndrome determined either by mutations of the coding region or by variation in the (TA)n motifs of the promoter region of the bilirubin UGT1A1 gene. The co-inheritance of Gilbert syndrome has been reported to elevate bilirubin levels in beta thalassemia and sickle cell disease patients. Aim In this study, we have tried to investigate whether the variability in serum bilirubin levels found in transfusion-dependent beta thalassemia, beta thalassemia intermedia, and heterozygous beta thalassemia individuals could be related to the coexistence of Gilbert syndrome. The promoter region (TA)n motifs of the bilirubin UGT1A1 gene were analyzed in 104 beta thalassemia individuals. The control group consisted of 50 healthy individuals. The analysis of the UGT1A1 promoter showed three (TA) motifs: (TA)5, (TA)6, and (TA)7. The frequency of genotype (TA)7/(TA)7 did not differ significantly between the groups studied. A significant difference was observed in mean serum bilirubin levels between individuals showing (TA)7/(TA)7 and (TA)6/(TA)6 genotypes and also between (TA)7/(TA)7 and (TA)6/(TA)7 genotypes among all groups studied. According to the beta genotype, no differences were observed between mean serum bilirubin levels in the three groups (β(+)/β(+), β(0)/β(+), and β(0)/β(0)). These results indicate that the (TA)7/(TA)7 configuration is one of the factors responsible for hyperbilirubinemia and, therefore, seems to interfere with the clinical expression of homozygous beta thalassemia. This emphasizes the role played by co-inherited modifying genes on clinical heterogeneity of monogenic disorders.

  19. Gilbert syndrome as a predisposing factor for cholelithiasis risk in the Greek adult population.

    Science.gov (United States)

    Tsezou, Aspasia; Tzetis, Maria; Giannatou, Eirini; Spanos, Ierotheos; Roma, Eleutheria; Fretzayas, Alexandros; Kanavakis, Emmanuel; Kitsiou-Tzeli, Sofia

    2009-02-01

    We investigated the hypothesis that coinheritance of the common A(TA)(n)TAA promoter mutation at the UGT1A1 locus associated with Gilbert syndrome is a risk factor for gallstone formation in a homogeneous adult population, by conducting a case-control study that included 198 adult patients with cholelithiasis and 152 healthy controls both of Greek origin. Three genotypes were found: 7/7 (17.8% in controls and 23.3% in patients), 6/7 (33.5% in controls and 46.5% in patients), and normal homozygous 6/6 (48.7% in controls and 30.3% in patients). The Gilbert UGT1A1 genotypes 6/7 and 7/7 show significant association (odds ratio 2.225, 95% confidence interval 1.373-3.605, p=0.001, and odds ratio 2.101, 95% confidence interval 1.171-3.770, p=0.013, respectively) with cholelithiasis risk. This association supports the theory that genetic factors are responsible for a fraction of symptomatic gallstone disease; however, further studies are required in different ethnic groups to fully elucidate the involvement of Gilbert syndrome in gallstone disease.

  20. Ulrich Beck : ostmine võib olla sama mõjus poliitiline osalusvorm kui valimaskäimine / Ulrich Beck ; interv. Indrek Ibrus

    Index Scriptorium Estoniae

    Beck, Ulrich

    2005-01-01

    Sotsioloog on seisukohal, et tänapäeval, kus teadusest ja majandusest on kujunenud poliitika, saab erasektorit ja teadlasi mõjutada tarbijakäitumise ning riikidevahelise koostöö suurendamisega. Lisa: Ulrich Beck

  1. A Journey, the Pain of Others, and Historical Experience: Susan Silas

    Directory of Open Access Journals (Sweden)

    Sendyka, Roma

    2014-12-01

    Full Text Available The author interprets Susan Silas' Helmbrechts walk (1998-2003, a unique series of forty-five photographs and supplementing visual and textual materials collected during the walk along the route of two hundred and twenty-five miles. The walk repeats the route which in 1945 had to undertake women prisoners from the concentration camp in Helmbrechts near Flossenbürg in their death march to Prachatice in Czech Republic. The pictures Silas takes, the people she meets, and finally the trees, the very materiality of the road become the factors of creating her own, individual memory of the event from the past. Silas selects an object from "the margins of the Holocaust" – a forgotten event that she re-presents by reacting to contemporary objects placed along the route of the event. Silas' work offers an opportunity to critically review the concept of memory landscapes (where is memory located in a landscape? and the phenomenon of dark tourism (is following in the footsteps of the prisoners a kind of pilgrimage, tourism, or therapy?. Silas problematises the question of memory, as well as examines different kinds of non-memory. Her camera is directed at locations that can be termed "the non-sites of memory."

  2. The Effect of Beck?s Cognitive Therapy and Mindfulness-Based Cognitive Therapy on Sociotropic and Autonomous Personality Styles in Patients With Depression

    OpenAIRE

    Abolghasemi, Abbas; Gholami, Hossin; Narimani, Mohammad; Gamji, Masood

    2015-01-01

    Background: Depression is characterized by a great risk of relapse and recurrence. Mindfulness-based cognitive therapy (MBCT) and cognitive therapy are efficacious psychosocial interventions for recurrent depression. Objectives: The aim of the present research was to compare the effect of Beck?s cognitive therapy (BCT) and MBCT on reduction of depression and sociotropic and autonomous personality styles in Iranian depressed patients. Patients and Methods: The study sample consisted of 30 subj...

  3. UNDERSTANDİNG SUSAN BORDO AND HER WORK; UNBEARABLE WEİGHT :FEMİNİSM, WESTERN CULTURE, BODY

    Directory of Open Access Journals (Sweden)

    ÇAĞLAR DEMİR

    2017-02-01

    Full Text Available Throughout history of thought, there have been many views about the women, their status in society, their struggle with patriarchy, and inequality  applied to them in all areas. There are different ways of oppression on women, such as confinement to home, inequality in wages between both sexes.  However, few scholars have written and declared their own views about how the patriarchal world and companies form women as they wish. Susan Bordo is one of  the most outstanding and distinguished feminist writers in the world who focuses on  how patriarchal capitalist understanding works on women’s body in terms of weight and weakness. According to Susan Bordo, male dominated capital world decides on women about what to wear and what to eat and women try to lose weight to be in the form men wish. State of  starving all the time leads to an illness called anorexia. The writer bases her views on the thoughts of literary critic and thinker, Foucault. The  objective of this article is to help the readers understand Susan Bordo’s views and analyse her impressive work; Unbearable Weight: Feminism, Western Culture and  the Body  and make her known in academic world.

  4. Comparison of Factor Structure Models for the Beck Depression Inventory--II

    Science.gov (United States)

    Ward, L. Charles

    2006-01-01

    Factor analyses of the Beck Depression Inventory--II (A. T. Beck, R. A. Steer, & G. K. Brown, 1996) have frequently produced 2 different 2-factor oblique structures. The author used confirmatory factor analyses to compare these structures with a general-factor model with 2 orthogonal group factors. The general-factor model fit as well as or…

  5. The Factor Structure of the Beck Depression Inventory-II: An Evaluation

    Science.gov (United States)

    Vanheule, Stijn; Desmet, Mattias; Groenvynck, Hans; Rosseel, Yves; Fontaine, Johnny

    2008-01-01

    The Beck Depression Inventory-II (BDI-II) is a frequently used scale for measuring depressive severity. BDI-II data (404 clinical; 695 nonclinical adults) were analyzed by means of confirmatory factor analysis to test whether the factor structure model with a somatic-affective and cognitive component of depression, formulated by Beck and…

  6. On the factor structure of the Beck Depression Inventory-II: G is the key

    NARCIS (Netherlands)

    Brouwer, D.; Meijer, R.R.; Zevalkink, D.J.

    2013-01-01

    The Beck Depression Inventory II (BDI-II; Beck, Steer, & Brown, 1996) is intended to measure severity of depression, and because items represent a broad range of depressive symptoms, some multidimensionality exists. In recent factor-analytic studies, there has been a debate about whether the BDI-II

  7. On the Factor Structure of the Beck Depression Inventory-II: G Is the Key

    Science.gov (United States)

    Brouwer, Danny; Meijer, Rob R.; Zevalkink, Jolien

    2013-01-01

    The Beck Depression Inventory-II (BDI-II; Beck, Steer, & Brown, 1996) is intended to measure severity of depression, and because items represent a broad range of depressive symptoms, some multidimensionality exists. In recent factor-analytic studies, there has been a debate about whether the BDI-II can be considered as one scale or whether…

  8. On the Factor Structure of the Beck Depression Inventory-II : G Is the Key

    NARCIS (Netherlands)

    Brouwer, Danny; Meijer, Rob R.; Zevalkink, Jolien

    The Beck Depression Inventory II (BDI-II; Beck, Steer, & Brown, 1996) is intended to measure severity of depression, and because items represent a broad range of depressive symptoms, some multidimensionality exists. In recent factor-analytic studies, there has been a debate about whether the BDI-II

  9. Interview with Elisabeth Beck-Gernsheim – family structures and family life in second modernity

    DEFF Research Database (Denmark)

    Ravn, Tine; Sørensen, Mads P.

    2013-01-01

    In this interview with Tine Ravn and Mads P. Sørensen, Elisabeth Beck-Gernsheim discusses family structures, reproductive technologies and individualization in second modernity.......In this interview with Tine Ravn and Mads P. Sørensen, Elisabeth Beck-Gernsheim discusses family structures, reproductive technologies and individualization in second modernity....

  10. Bárbara Mujica, ed., Shakespeare and the Spanish «Comedia». Translation, Interpretation, Performance. Essays in Honor of Susan L. Fischer

    Directory of Open Access Journals (Sweden)

    Alejandro García-Reidy

    2016-01-01

    Full Text Available Reseña de Bárbara Mujica, ed., Shakespeare and the Spanish «Comedia». Translation, Interpretation, Performance. Essays in Honor of Susan L. Fischer, Bucknell University Press, Lewisburg, 2013, 298 pp. ISBN 9781611485172.

  11. Standardization of the Beck Hopelessness Scale in the general population.

    Science.gov (United States)

    Kocalevent, Rüya-Daniela; Finck, Carolyn; Pérez-Trujillo, Mónica; Sautier, Leon; Zill, Jördis; Hinz, Andreas

    2017-12-01

    The Beck Hopelessness Scale (BHS) is a self-report instrument for the quantification of hopelessness in nonpsychiatric, as well as psychiatric patients. Hopelessness is a key psychological variable in suicide prediction. Until now the psychometric properties of the instrument have not been studied in a representative sample of the general population. The objectives of the study were to generate normative data and to further investigate the construct validity and factorial structure of the BHS. A nationally representative face-to-face household survey was conducted in Colombia in 2012 (N = 1500). Cronbach's alpha coefficient for the BHS was 0.81. Confirmatory factor analysis supported a three-factor model, achieving good fit indices (total sample: RMSEA = 0.043, CFI = 0.936, TLI = 0.921). Normative data for the BHS were generated for both genders and different age levels. Intercorrelations with hopelessness were highest for depression (r = 0.57), followed by anxiety (r = 0.52). The normative data provide a framework for the interpretation and comparisons of the BHS with other populations. Evidence supports reliability and validity of the three-factor BHS as a measure of hopelessness in the general population.

  12. Consistencia interna y estructura factorial de la Escala de Desesperanza de Beck en estudiantes mexicanos

    Directory of Open Access Journals (Sweden)

    Martha Córdova Osnaya

    2011-12-01

    Full Text Available Internal consistency and factorial structure of the Beck Hopelessness Scale among Mexican students The Beck Hopelessness Scale was applied in a sample of 971 male and female students, chosen at random sampling from Mexico City, with an average age of 16.75 years. Results were compared to those reported by Beck, Weissman, Lester and Trexler (1974. Results showed adequate reliability (≥ 0.70 in the total sample by gender. Factorial structure matched only in the Affective factor as reported by Beck et al. (1974 with respect to the total sample. Differences in saturation and factorial structure in both sexes were observed. It was concluded that the factor structure of Beck Hopelessness Scale registers different factor structure in the total sample, according to sex.

  13. Podróż, cudze cierpienie i doświadczenie historyczne: Susan Silas

    Directory of Open Access Journals (Sweden)

    Sendyka, Roma

    2014-12-01

    Full Text Available Autorka interpretuje pracę Susan Silas Helmbrechts walk (1998-2003, szczególny cykl czterdziestu pięciu zdjęć i dołączonych do nich materiałów wizualnych oraz tekstowych zbudowany podczas przejścia trasy dwustu dwudziestu pięciu mil, które w 1945 roku musiały przebyć kobiety pędzone w marszu śmierci z Helmbrecht koło Flossenbürga do czeskich Prachatic. Wykonywane zdjęcia, napotykani ludzie, w końcu – drzewa, sama materialność drogi stają się czynnikami wytwarzania własnej, indywidualnej pamięci wydarzenia sprzed lat. Silas wybiera szczególny obiekt "z marginesów Zagłady" – zapomniane zdarzenie, które przedstawia obserwując współczesne obiekty położone wzdłuż trasy tego zdarzenia. Praca Silas pozwala przyjrzeć się krytycznie koncepcji memory landscapes (gdzie w krajobrazie umiejscawia się pamięć? i zjawisku dark tourism (czy podążanie śladami więźniarek to pielgrzymka, turystyka czy terapia?. Silas problematyzuje nie tylko kwestię pamięci, bada również rodzaje nie-pamiętania. Jej kamera zostaje zwrócona ku lokalizacjom, które można nazwać "nie-miejscami pamięci".

  14. Treasure Your Exceptions: An Interview with 2017 George Beadle Award Recipient Susan A. Gerbi.

    Science.gov (United States)

    Gerbi, Susan A

    2017-12-01

    THE Genetics Society of America's (GSA) George W. Beadle Award honors individuals who have made outstanding contributions to the community of genetics researchers and who exemplify the qualities of its namesake. The 2017 recipient is Susan A. Gerbi, who has been a prominent leader and advocate for the scientific community. In the course of her research on DNA replication, Gerbi helped develop the method of Replication Initiation Point (RIP) mapping to map replication origins at the nucleotide level, improving resolution by two orders of magnitude. RIP mapping also provides the basis for the now popular use of λ-exonuclease to enrich nascent DNA to map replication origins genome-wide. Gerbi's second area of research on ribosomal RNA revealed a conserved core secondary structure, as well as conserved nucleotide elements (CNEs). Some CNEs are universally conserved, while other CNEs are conserved in all eukaryotes but not in archaea or bacteria, suggesting a eukaryotic function. Intriguingly, the majority of the eukaryotic-specific CNEs line the tunnel of the large ribosomal subunit through which the nascent polypeptide exits. Gerbi has promoted the fly Sciara coprophila as a model organism ever since she used its enormous polytene chromosomes to help develop the method of in situ hybridization during her Ph.D. research in Joe Gall's laboratory. The Gerbi laboratory maintains the Sciara International Stock Center and manages its future, actively spreading Sciara stocks to other laboratories. Gerbi has also served in many leadership roles, working on issues of science policy, women in science, scientific training, and career preparation. This is an abridged version of the interview. The full interview is available on the Genes to Genomes blog, at genestogenomes.org/gerbi. Copyright © 2017 by the Genetics Society of America.

  15. A centennial tribute to G.K. Gilbert's Hydraulic Mining Débris in the Sierra Nevada

    Science.gov (United States)

    James, L. A.; Phillips, J. D.; Lecce, S. A.

    2017-10-01

    G.K. Gilbert's (1917) classic monograph, Hydraulic-Mining Débris in the Sierra Nevada, is described and put into the context of modern geomorphic knowledge. The emphasis here is on large-scale applied fluvial geomorphology, but other key elements-e.g., coastal geomorphology-are also briefly covered. A brief synopsis outlines key elements of the monograph, followed by discussions of highly influential aspects including the integrated watershed perspective, the extreme example of anthropogenic sedimentation, computation of a quantitative, semidistributed sediment budget, and advent of sediment-wave theory. Although Gilbert did not address concepts of equilibrium and grade in much detail, the rivers of the northwestern Sierra Nevada were highly disrupted and thrown into a condition of nonequilibrium. Therefore, concepts of equilibrium and grade-for which Gilbert's early work is often cited-are discussed. Gilbert's work is put into the context of complex nonlinear dynamics in geomorphic systems and how these concepts can be used to interpret the nonequilibrium systems described by Gilbert. Broad, basin-scale studies were common in the period, but few were as quantitative and empirically rigorous or employed such a range of methodologies as PP105. None demonstrated such an extreme case of anthropogeomorphic change.

  16. Relation between Neonatal Icter and Gilbert Syndrome in Gloucose-6-Phosphate Dehydrogenase Deficient Subjects.

    Science.gov (United States)

    Zahedpasha, Yadollah; Ahmadpour, Mousa; Niaki, Haleh Akhavan; Alaee, Ehsan

    2014-03-01

    The pathogenesis of neonatal hyperbilirubinemia hasn't been completely defined in Gloucose-6-Phosphate Dehydrogenase (G6PD) deficient newborns. The aim of this study was to detect the relationship between Gilbert's syndrome and hyperbilirubinemia in Gloucose-6-Phosphate Dehydrogenase (G6PD) deficient neonates. This case-control study was conducted in Amirkola pediatrics teaching hospital, Babol, Iran. A total number of one hundred four infants were included in the study (51 infants with neonatal jaundice and Gloucose-6-Phosphate Dehydrogenase (G6PD) deficiency admitted to phototherapy or transfusion were selected as the case group and 53 infants with Gloucose-6-Phosphate Dehydrogenase (G6PD) deficiency admitted for other reasons than jaundice were selected as the control group). Exclusion criteria were ABO or Rh incompatibility or other reasons that made Coombs test positive, sepsis, hepatosplenomegaly, metabolic diseases, medical treatment and phototherapy. The promoter and coding regions of Uridine diphosphate Glucuronosyl Transferase 1A1 (UGT1A1) of genomic DNA were amplified by polymerase chain reaction (PCR) isolated from leukocytes. We used chi-square test and t-test to compare cases and controls. Distribution of Gilbert genome was not significantly different between the two groups; among cases, 33.3% were homozygote, 35.3% heterozygote, and 31.4% normal. Among controls, 22.6% were homozygote, 34% heterozygote, and 43.4% normal (p-value=xxx). Hyperbilirubinemia family history didn't differ significantly between these two groups. We showed that in Gloucose-6-Phosphate Dehydrogenase (G6PD) deficient neonates, there was no significant association between Gilbert's syndrome (promoter polymorphism) and hyperbilirubinemia.

  17. Semi-implicit integration scheme for Landau-Lifshitz-Gilbert-Slonczewski equation

    Science.gov (United States)

    Giordano, A.; Finocchio, G.; Torres, L.; Carpentieri, M.; Azzerboni, B.

    2012-04-01

    This paper shows how to implement a semi-implicit algorithm based on the Adams-Bashforth algorithm as a predictor, and a second order Adams-Moulton procedure as a corrector in the Landau-Lifshitz-Gilbert-Slonczewski equation. We compare the results with a Runge-Kutta scheme of the 5th order, while for the standard problem #4 (and, in general, for the LLG equation) the computational speeds are of the same order, and we found better performance when the thermal fluctuations or the spin-polarized currents are taken into account.

  18. Ginzburg-Landau vortices driven by the Landau-Lifshitz-Gilbert equation

    Energy Technology Data Exchange (ETDEWEB)

    Kurzke, Matthias; Melcher, Christof; Moser, Roger; Spirn, Daniel

    2009-06-15

    A simplified model for the energy of the magnetization of a thin ferromagnetic film gives rise to a version of the theory of Ginzburg-Landau vortices for sphere-valued maps. In particular we have the development of vortices as a certain parameter tends to 0. The dynamics of the magnetization is ruled by the Landau-Lifshitz-Gilbert equation, which combines characteristic properties of a nonlinear Schroedinger equation and a gradient flow. This paper studies the motion of the vortex centers under this evolution equation. (orig.)

  19. Transient analysis of scattering from ferromagnetic objects using Landau-Lifshitz-Gilbert and volume integral equations

    KAUST Repository

    Sayed, Sadeed Bin

    2016-11-02

    An explicit marching on-in-time scheme for analyzing transient electromagnetic wave interactions on ferromagnetic scatterers is described. The proposed method solves a coupled system of time domain magnetic field volume integral and Landau-Lifshitz-Gilbert (LLG) equations. The unknown fluxes and fields are discretized using full and half Schaubert-Wilton-Glisson functions in space and bandlimited temporal interpolation functions in time. The coupled system is cast in the form of an ordinary differential equation and integrated in time using a PE(CE)m type linear multistep method to obtain the unknown expansion coefficients. Numerical results demonstrating the stability and accuracy of the proposed scheme are presented.

  20. Observation of Coherent Helimagnons and Gilbert Damping in an Itinerant Magnet

    Energy Technology Data Exchange (ETDEWEB)

    Koralek, J. D.; Meier, D.; Hinton, J. P.; Bauer, A.; Parameswaran, S. A.; Vishwanath, A.; Ramesh, R.; Schoenlein, R. W.; Pfleiderer, C.; Orenstein, J.

    2012-12-01

    We study the magnetic excitations of itinerant helimagnets by applying time-resolved optical spectroscopy to Fe0:8Co0:2Si. Optically excited oscillations of the magnetization in the helical state are found to disperse to lower frequency as the applied magnetic field is increased; the fingerprint of collective modes unique to helimagnets, known as helimagnons. The use of time-resolved spectroscopy allows us to address the fundamental magnetic relaxation processes by directly measuring the Gilbert damping, revealing the versatility of spin dynamics in chiral magnets.

  1. Size stratification in a Gilbert delta due to a varying base level: flume experiments.

    Science.gov (United States)

    Chavarrias, Victor; Orru, Clara; Viparelli, Enrica; Vide, Juan Pedro Martin; Blom, Astrid

    2014-05-01

    A foreset-dominated Gilbert delta is a delta that is dominated by sediment avalanches (i.e., discontinuous grain flows) over its front. It forms when a river flows into a basin or sea characterized by a flow depth that is much larger than the one in the fluvial reach, and the conditions are such that the transported sediment passing the brinkpoint forms a wedge at the topmost part of the foreset, which results in avalanches down the foreset and a fining upward pattern within the foreset deposit. A Gilbert delta is typically described in terms of a low-slope topset (resulting from deposition over the fluvial reach), a steep-slope foreset (resulting from sediment avalanches over the lee face), and a bottomset (resulting from deposition of fine sediment passing the brinkpoint as suspended load). The objective of the present study is to gain insight into the mechanisms taking part in Gilbert delta formation and progradation under variable base level conditions. In order to do so, three flume experiments were conducted in which the water discharge and sediment feed rate were maintained constant but the base level varied between the experiments: (I) constant base level, (II) a gradually rising base level, and (III) a slowly varying base level. The stratigraphy within the delta deposit was measured using image analysis combined with particle coloring. A steady base level resulted in aggradation over the fluvial reach in order to maintain a slope required to transport the supplied sediment downstream. Sea level rise enhanced the amount of aggradation over the fluvial reach due to the presence of an M1 backwater curve. The aggrading flux to the substrate was slightly coarser than the fed sediment. The sediment at the base of the foreset deposit appeared to become coarser in streamwise direction. Eventually, a fall of the base level induced an M2 backwater curve over the fluvial reach that caused degradation of the fluvial reach. Base level fall first induced erosion of the

  2. GUSTAVE MARK GILBERT: SEXTO PRESIDENTE DE LA SOCIEDAD INTERAMERICANA DE PSICOLOGÍA

    Directory of Open Access Journals (Sweden)

    Victor A. Colotla

    2015-01-01

    Full Text Available Este art í culo presenta una breve biografía de Gustave M. Gilbert (1911 - 1977, sexto presidente de la Sociedad Interamerican a de Psicología (SIP. Se describen datos biográficos, su papel como psicólogo de la cárcel de Núremberg y su contribución a la psicología de las dictaduras, para finalizar con su contacto con la psicología interamericana a través de la SIP.

  3. Correlation between the Beck Depression Inventory and bariatric surgical procedures.

    Science.gov (United States)

    Ayloo, Subhashini; Thompson, Kara; Choudhury, Nabajit; Sheriffdeen, Raiyah

    2015-01-01

    The Beck Depression Inventory (BDI) is a psychosocial screen for depression in obese patients seeking bariatric surgery. Gastric bypass improves postsurgical BDI scores due to weight loss, which predicts future weight loss. The effect of different bariatric procedures with differences in weight loss on BDI scores is unknown. To evaluate the relationship between different bariatric procedures and changes in the BDI scores, adjusting for the initial BDI score, and to consider the impact of psychosocial variables. The secondary objective was to assess the relationship between changes in BDI scores and weight loss at 6 to 12 months. University Hospital, United States. Bariatric surgical patients were prospectively enrolled and retrospectively reviewed. We assessed changes in BDI after adjusting for the presurgical BDI and analyzed the relationship between patient demographic characteristics/psychological disorders and changes in BDI. We enrolled 137 patients who underwent a gastric band procedure, sleeve gastrectomy, or gastric bypass. We found a significant decrease in BMI and BDI scores across the full sample. Unlike BDI, change in BMI varied with procedure. Normalizing for baseline BDI, change in BDI did not significantly correlate with change in BMI. Patients who were employed and those without psychiatric history experienced even greater improvement in BDI scores. No statistically significant correlation was found between the change in BDI and weight loss at 6-12 months. BDI scores were independent of the type of bariatric procedure and the amount of weight loss. Advantageous psychosocial parameters were associated with greater improvement in BDI scores. Copyright © 2015 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

  4. The Predictive Validity of the Beck Depression Inventory Suicide Item.

    Science.gov (United States)

    Green, Kelly L; Brown, Gregory K; Jager-Hyman, Shari; Cha, Jason; Steer, Robert A; Beck, Aaron T

    2015-12-01

    The current study examines the predictive validity of the Beck Depression Inventory (BDI) suicide item for death by suicide and suicide attempts. The study included 2 samples: (1) 5,200 psychiatric outpatients who were evaluated between 1975 and 1995 and followed prospectively for up to 20 years (all psychiatric diagnoses based on DSM-III and DSM-III-R), and (2) 119 patients who, between 2000 and 2004, participated in a randomized controlled trial of outpatient Cognitive Therapy for Suicide Prevention after a suicide attempt and were followed for 18 months (all psychiatric diagnoses based on DSM-IV-TR). All patients completed structured diagnostic interviews, as well as the BDI and Scale for Suicide Ideation. Cox regression models demonstrated that the BDI suicide item significantly predicted both deaths by suicide (Wald χ(2)1 = 35.67; P < .001 [N = 5,200]) and repeat suicide attempts (Wald χ(2)1 = 8.82; P < .01 [N = 119]), with each successive rating on the item conferring greater risk. Using receiver operating characteristic (ROC) curves, optimal cutoff scores of 1 and above for suicide and 2 and above for suicide attempts were identified as providing the best balance between sensitivity and specificity. The BDI suicide item is associated with both risk of repeat suicide attempts and death by suicide. The use of the item as a brief, efficient screen for suicide risk in routine clinical care is recommended. Clinicians would then conduct a comprehensive suicide risk assessment in response to a positive screen. Future research examining the item's performance in other at-risk groups (ie, older adults, adolescents, inpatients, etc) is encouraged. © Copyright 2015 Physicians Postgraduate Press, Inc.

  5. Gilbert's Syndrome

    Science.gov (United States)

    ... as a cold or the flu Fasting or eating a very low-calorie diet Dehydration Menstruation Stress Strenuous exercise Lack of sleep When to see ... extremely low-calorie diets. Stick to a routine eating schedule, and avoid fasting or skipping meals. Manage stress. Find ways to deal with the stresses in ...

  6. Self-similar solutions of the one-dimensional Landau-Lifshitz-Gilbert equation

    Science.gov (United States)

    Gutiérrez, Susana; de Laire, André

    2015-05-01

    We consider the one-dimensional Landau-Lifshitz-Gilbert (LLG) equation, a model describing the dynamics for the spin in ferromagnetic materials. Our main aim is the analytical study of the bi-parametric family of self-similar solutions of this model. In the presence of damping, our construction provides a family of global solutions of the LLG equation which are associated with discontinuous initial data of infinite (total) energy, and which are smooth and have finite energy for all positive times. Special emphasis will be given to the behaviour of this family of solutions with respect to the Gilbert damping parameter. We would like to emphasize that our analysis also includes the study of self-similar solutions of the Schrödinger map and the heat flow for harmonic maps into the 2-sphere as special cases. In particular, the results presented here recover some of the previously known results in the setting of the 1D-Schrödinger map equation.

  7. Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Hongmin [Cancer Center, School of Public Health, West Virginia University, Morgantown, WV 265050-9190 (United States); Department of Epidemiology and Statistics, School of Public Health, Hebei United University, Hebei 063000 (China); Ducatman, Alan [Department of Occupational and Environmental Health, School of Public Health, West Virginia University (United States); Department of Medicine, School of Medicine, West Virginia University (United States); Clinical Translational Science Institute, West Virginia University (United States); Zhang, Jianjun [Department of Biostatistics, School Public Health, West Virginia University (United States)

    2014-11-15

    Background: Gilbert syndrome (GS) is an inherited defect of bilirubin conjugation, most commonly caused by a gene mutation for the enzyme UGT1A. GS is known to affect the metabolism and excretion of drugs and xenobiotics. Perfluorocarbon compounds (PFCs) are bio-persistent environmental contaminants that affect metabolic regulation. In this study, we examined the associations of GS phenotype and serum PFCs in the C8 Health Study Population. Materials and methods: Using 2005–2006 data from a large PFC-exposure population survey, we compared serum PFCs concentrations between GS and non GS clinical phenotypes, in a cross sectional design, adjusting for standard risk factors, including age, BMI, smoking status, socioeconomic status and gender. Results: Among 10 PFC compounds considered, only perfluorohexanoic acid (PFHxA) was seen at a significantly higher concentration in GS men and women. Conclusion: PFHxA exposure may be associated with GS. Our findings do not support increased exposure in GS for other PFCs. - Highlights: • Most serum PFCs are not associated with clinically evident Gilbert syndrome. • However, serum perfluorohexanoic acid is positively associated. • The investigation addresses the clinical presentation, not the genetic mutation.

  8. Individuação, percepção, ambiente: Merleau-Ponty e Gilbert Simondon Individuation, perception, environment: Merleau-Ponty and Gilbert Simondon

    Directory of Open Access Journals (Sweden)

    Andréia A. Marin

    2009-12-01

    Full Text Available Este trabalho trata da individuação e da percepção a partir de duas filosofias contemporâneas: os fundamentos fenomenológicos da percepção (Merleau-Ponty e as relações entre percepção e individuação (Gilbert Simondon. Essas duas composições teóricas podem criar outros espaços de reflexão para as pesquisas em percepção ambiental. A percepção primordial, a importância da corporeidade como redescoberta do mundo vivido e a experiência estética que instaura os espaços de criação nas artes são categorias merleau-pontianas que permitem redimensionar os significados da relação humano-ambiente. O "diálogo" entre essas experiências de criação (discutidas por Merleau-Ponty e os processos de individuação da/com a percepção (Simondon pode suscitar novas abordagens de partida para estudos em percepção ambiental, inspirando novas possibilidades no domínio da Educação Ambiental.This work deals with individuation and perception from two contemporary philosophies. Phenomenological foundations of perception (Merleau-Ponty and the connections between perception and individuation (Gilbert Simondon. These two theoretical compositions may encourage reflections on researches into environmental perception. The primordial perception, the importance of corporeity as the rediscovery of a living world and the aesthetic experience that may restore spaces of creation in the arts are Merleau-Ponty's categories which allow a re-evaluation of the human-environment relationship. The "dialog" between these creation experiences (Merleau-Ponty and the processes of individuation of/with perception (Simondon may suggest new approaches to studies in environmental perception, inspire new possibilities in environmental education.

  9. Crigler-Najjar syndrome type I in a Turkish newborn caused by a novel mutation and Gilbert type genetic defect.

    Science.gov (United States)

    Yildiz, D; Alan, S; Kilic, A; Yaman, A; Erdeve, O; Kuloglu, Z; Atasay, B; Arsan, S

    2013-01-01

    Crigler-Najjar syndrome (CNS), caused by deficiency of bilirubin uridine diphosphate glucuronosyltransferase (UGT) 1A1, is a rare and autosomal recessive inherited disorder characterized by severe unconjugated nonhemolytic hyperbilirubinemia since birth. We present a girl with CNS type I caused by a novel mutation and Gilbert type genetic defect. Gilbert's Syndrome (GS) and CNS type I both involve abnormalities in bilirubin conjugation secondary to deficiency of bilirubin UGT. The combined defects even in benign genetic forms were shown to cause more serious clinical disease. The patient has been treated with daily home-based phototherapy for more than nine months and considered as a candidate for liver transplantation.

  10. [Gunnar Meyer. "Besitzende Bürger" und "Elende Sieche". Lübecks Gesellschaft im Spiegel ihrer Testamente 1400-1449] / Dennis Hortmuth

    Index Scriptorium Estoniae

    Hormuth, Dennis

    2012-01-01

    Arvustus: Gunnar Meyer. "Besitzende Bürger" und "Elende Sieche". Lübecks Gesellschaft im Spiegel ihrer Testamente 1400-1449. (Verhöffentlichungen zur Geschichte der Hansestadt Lübeck. B. 48). (Lübeck, 2010)

  11. „Cinemagraphs” Jamie Beck w kontekście dramatycznej teorii literatury

    OpenAIRE

    Woźniak, Ewelina

    2012-01-01

    The purpose of this article is to present works of a New York photographer Jamie Beck, who developed a new type of moving photography – cinemagraphs, and look at her work from the perspective of the dramatic theory of literature. Jamie Beck in her works redefines many notions related to the visual realm. Movement and time relationship, the model identity and the impact of material on the image perception are the most interesting problems, that are connected with cinemagraphs. A...

  12. Psychometric Properties of the Beck Scale for Depression (Beck Depression Inventory BDI-II)--A Study on a Sample of Students in the State of Kuwait Universities

    Science.gov (United States)

    Dahem, Ahmed Mohammed Faleh

    2016-01-01

    The study aimed to identify the psychometric properties of the Beck Depression Inventory (BDI-II) the Arabized version by Gharib (2000); the study sample consisted of 500 male and female students from the Kuwaiti universities by 250 males and 250 females on whom the BDI-II scale was applied twice; the psychometric characteristics such as the…

  13. Comics and the Structure of Childhood Feeling: Sublimation and the Play of Pretending in Gilbert Hernandez's "Marble Season"

    Science.gov (United States)

    Lewkowich, David

    2016-01-01

    In this paper, I study the narrative structure of comics as a means to describe the ways that indeterminate modes of representation can allow the reader to imagine that which in childhood can never be fully expressed. Analyzing a number of panels from Gilbert Hernandez's graphic novel, "Marble Season," I describe a conceptual link…

  14. Temperature-dependent Gilbert damping of Co2FeAl thin films with different degree of atomic order

    Science.gov (United States)

    Kumar, Ankit; Pan, Fan; Husain, Sajid; Akansel, Serkan; Brucas, Rimantas; Bergqvist, Lars; Chaudhary, Sujeet; Svedlindh, Peter

    2017-12-01

    Half-metallicity and low magnetic damping are perpetually sought for spintronics materials, and full Heusler compounds in this respect provide outstanding properties. However, it is challenging to obtain the well-ordered half-metallic phase in as-deposited full Heusler compound thin films, and theory has struggled to establish a fundamental understanding of the temperature-dependent Gilbert damping in these systems. Here we present a study of the temperature-dependent Gilbert damping of differently ordered as-deposited Co2FeAl full Heusler compound thin films. The sum of inter- and intraband electron scattering in conjunction with the finite electron lifetime in Bloch states governs the Gilbert damping for the well-ordered phase, in contrast to the damping of partially ordered and disordered phases which is governed by interband electronic scattering alone. These results, especially the ultralow room-temperature intrinsic damping observed for the well-ordered phase, provide fundamental insights into the physical origin of the Gilbert damping in full Heusler compound thin films.

  15. Through the Use of Gilbert's Behavioral Engineering Model, What Changes Can Management Make to Increase Blood Donations?

    Science.gov (United States)

    Russell, Heather Gordy

    2010-01-01

    The mixed method study focused on increasing blood donations from staff who work in a blood collecting organization and relies on Gilbert's Behavior Engineering Model as a framework. The qualitative phase of the study involved focus groups. Information from the focus groups and the literature review were used to create hypotheses. A survey was…

  16. Author's Response to Commentaries on: "An Interpretation of Part of Gilbert Gottlieb's Legacy: Developmental Systems Theory Contra Developmental Behavior Genetics"

    Science.gov (United States)

    Molenaar, Peter C. M.

    2015-01-01

    In this article, Peter Molenaar responds to three commentaries (this issue) on his article, "An Interpretation of Part of Gilbert Gottlieb's Legacy: Developmental Systems Theory Contra Developmental Behavior Genetics." He addresses aspects of relational developmental systems (RDS) mentioned and questions raised in each of the…

  17. A finite element approximation for the stochastic Landau-Lifshitz-Gilbert equation

    Science.gov (United States)

    Goldys, Beniamin; Le, Kim-Ngan; Tran, Thanh

    2016-01-01

    The stochastic Landau-Lifshitz-Gilbert (LLG) equation describes the behaviour of the magnetisation under the influence of the effective field containing random fluctuations. We first transform the stochastic LLG equation into a partial differential equation with random coefficients (without the Itô term). The resulting equation has time-differentiable solutions. We then propose a convergent θ-linear scheme for the numerical solution of the reformulated equation. As a consequence, we show the existence of weak martingale solutions to the stochastic LLG equation. A salient feature of this scheme is that it does not involve solving a system of nonlinear algebraic equations, and that no condition on time and space steps is required when θ ∈ (1/2 , 1 ]. Numerical results are presented to show the applicability of the method.

  18. Replication and Pedagogy in the History of Psychology IV: Patrick and Gilbert (1896) on Sleep Deprivation

    Science.gov (United States)

    Fuchs, Thomas; Burgdorf, Jeffrey

    2008-05-01

    We report an attempted replication of G. T. W. Patrick and J. A. Gilbert’s pioneering sleep deprivation experiment ‘Studies from the psychological laboratory of the University of Iowa. On the effects of loss of sleep’, conducted in 1895/96. Patrick and Gilbert’s study was the first sleep deprivation experiment of its kind, performed by some of the first formally trained psychologists. We attempted to recreate the original experience in two subjects, using similar apparatus and methodology, and drawing direct comparisons to the original study whenever possible. We argue for a strong influence of an ‘Americanized’ Wundtian psychology on Patrick and Gilbert, a claim supported biographically by their education and by their experimental methods. The replication thus opens interesting new perspectives, which are unlikely to be generated by any other historical approach.

  19. Scoliosis in a Patient With Gilbert Syndrome: A Case Report and Review of the Literature.

    Science.gov (United States)

    Li, Zheng; Shen, Jianxiong; Liang, Jinqian

    2015-11-01

    Gilbert syndrome (GS) is mainly characterized by intermittent unconjugated hyperbilirubinemia in the absence of hepatocellular disease or hemolysis. Little data are available on operative outcomes in GS patients with spinal deformity surgery.This study has presented a case of GS occurring in the patient with scoliosis.The patient was a 30-year-old female with scoliosis and GS. She was taken a correction form Thoracic 2 to Lumbar 1) levels by using the USS-II spinal system. At 2 years follow-up, the patient was well balanced and pain free. Plain radiographs demonstrated spine solid fusion without correction loss.Although complex scoliosis surgery can be performed safely in these patients with GS, careful perioperative managements including liver function and coagulation function are required.

  20. The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert`s syndrome: an observational study.

    Science.gov (United States)

    Cüre, Erkan; Ciçek, Yüksel; Cumhur Cüre, Medine; Yüce, Süleyman; Kırbaş, Aynur; Yılmaz, Arif

    2013-12-01

    Atherosclerotic heart diseases are less frequently seen in patients with Gilbert's syndrome (GS). We aimed to investigate whether serum adiponectin (APN) and epicardial adipose tissue (EAT) thickness have an effect beside the antioxidant effect of bilirubin in lowering the incidence of the atherosclerotic process. Sixty-eight patients diagnosed with GS (39 females and 29 males) who had applied at the internal medicine clinic of the hospital were included in this cross-sectional, observational study. The control group included 63 healthy people (39 females and 24 males). EAT thickness was measured by echocardiography. The serum APN levels were also checked. Statistical analysis was performed by using independent sample t-test, Pearson correlation and linear regression analyses. The mean age of the GS group was 28 ± 9 years, and the average EAT thickness was found to be 2.5 ± 0.1 mm. The mean age of the control group was 26 ± 6 years, and the average EAT thickness was found to be 4.2 ± 0.5 mm. When comparing the two groups, the EAT thickness of the GS group was found to be significantly lower (p<0.001) than that of the control group. In the GS group the APN was 14.9 ± 4.2 mg/L, and in the control group the APN was 12.6 ± 4.5 mg/L (p<0.022). We found that total bilirubin (β=-1,607, p<0,001) and indirect bilirubin (β=1,086, p<0,001) have an independent association with decreased EAT thickness. EAT thickness is associated with coronary atherosclerosis. Low EAT thickness may be related with low release of proinflammatory cytokine. High levels of APN may be related high anti-inflammatory effect. Therefore, low EAT thickness and high levels of APN may demonstrate protective effect on atherosclerotic heart diseases in GS patients.

  1. Use of the Beck Depression Inventory-II with depressed geriatric inpatients.

    Science.gov (United States)

    Steer, R A; Rissmiller, D J; Beck, A T

    2000-03-01

    To provide information about the clinical utility of the Beck Depression Inventory-II (BDI-II) [Beck, A.T., Steer, R.A., & Brown, G.K. (1996b). Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation] with geriatric inpatients, the BDI-II was administered to 130 psychiatric inpatients who were 55 years old or above and who were diagnosed with principal DSM-IV major depressive disorders (MDD) (N = 85, 65%) or adjustment disorders with depressed mood (N = 45, 35%). The internal consistency of the BDI-II was high (coefficient alpha = 0.90), and its total score was not significantly related to sex, age, or ethnicity. An iterated maximum-likelihood factor analysis found the Cognitive and Noncognitive dimensions which have been reported for the BDI-II by Steer and co-workers (Steer R.A., Ball R., Ranieri W.F., & Beck A.T. (1999). Dimensions of the Beck Depression Inventory-II in clinically depressed outpatients. Journal of Psychopathology and Behavioral Assessment, 55, 117-128) in a younger sample of clinically depressed psychiatric outpatients. The mean BDI-II total score of the 85 geriatric inpatients with MDD was also comparable to that of 42 younger (< or = 54 years old) inpatients with MDD. The results were discussed as supporting the use of the BDI-II with clinically depressed geriatric inpatients.

  2. Susan Magoffin’s Santa Fe Days in 1846: The Value of Testimony Les journées de Santa Fé en 1846 de Susan Magoffin : la valeur du témoignage

    Directory of Open Access Journals (Sweden)

    Susanne Berthier-Foglar

    2009-11-01

    Full Text Available Susan Magoffin, la jeune épouse d’un commerçant de la piste de Santa Fe, accompagna son mari en 1846 pour un voyage où la caravane suivait de près l’Armée de l’Ouest et pendant lequel elle tint un journal. Cet article traite des 37 jours que dura la pause de la caravane à Santa Fe et aborde plus spécifiquement la façon dont l’auteur appréhendait l’altérité dans un environnement inhabituel et parfois dangereux. Pour apprécier la valeur du témoignage, je combine une analyse du discours avec une évaluation statistique du contenu. La description, parfois naïve, de Santa Fe sous l’occupation américaine illustre les raisons de la guerre contre le Mexique. En tant qu’agent de la destinée manifeste, Susan Magoffin admirait le général Kearny en lui attribuant des qualités surhumaines et en participant à ses efforts de propagande. Alors qu’elle était enracinée dans sa classe et sa culture, elle voyait la population mexicaine et les Amérindiens avec un esprit ouvert bien que ses motifs pour apprendre l’espagnol, ainsi que le métier de commerçante, avaient une fonction plus prosaïque.

  3. A individualização em Ulrich Beck: análise da sociedade contemporânea (Individualization in Ulrich Beck: an analysis of contemporary society

    Directory of Open Access Journals (Sweden)

    Vera Herweg Westphal

    2010-01-01

    Full Text Available Resumo: A individualização é tema da análise sociológica contemporânea e Ulrich Beck analisa esse processo no contexto de mudanças da primeira para a segunda modernidade. Na modernização reflexiva, marcada por riscos, há transformações relacionadas ao mundo do trabalho, à família, à política e ao lugar e papel do indivíduo na sociedade, ocorrendo a reflexividade da modernidade sobre ela mesma. Nesse processo, o indivíduo passou a ser a unidade referencial do social. A individualização é ambivalente, pois, ao libertar o indivíduo de padrões e referências tradicionais, implica novas liberdades, marcada por riscos. Para a análise da sociedade, Beck propõe alguns critérios que serão abordados neste artigo.Abstract: Individualization is one of the issues discussed in the contemporary sociological analysis. Ulrich Beck is one of the authors who analyze this process in the context of the changing from the first to the second modernity. The second modernity, which is marked by risks, experiences a reflexive modernization, in which significant changes took place in the work sphere, in the family, in politics and in the placing and role of individuals. Therefore, what occurs is the reflexivity of modernity upon itself. In this process, the individuals became the referential unit of society. Individualization is ambivalent, in the sense that while it sets the individuals free from traditional standards and references, it also entails new types of freedom, characterized by impending risks. Beck proposes some criteria for the analysis of society, which will be examined in this article.

  4. Validity study of the Beck Anxiety Inventory (Portuguese version by the Rasch Rating Scale model

    Directory of Open Access Journals (Sweden)

    Sónia Quintão

    2013-01-01

    Full Text Available Our objective was to conduct a validation study of the Portuguese version of the Beck Anxiety Inventory (BAI by means of the Rasch Rating Scale Model, and then compare it with the most used scales of anxiety in Portugal. The sample consisted of 1,160 adults (427 men and 733 women, aged 18-82 years old (M=33.39; SD=11.85. Instruments were Beck Anxiety Inventory, State-Trait Anxiety Inventory and Zung Self-Rating Anxiety Scale. It was found that Beck Anxiety Inventory's system of four categories, the data-model fit, and people reliability were adequate. The measure can be considered as unidimensional. Gender and age-related differences were not a threat to the validity. BAI correlated significantly with other anxiety measures. In conclusion, BAI shows good psychometric quality.

  5. Assessment of depression in medical patients: A systematic review of the utility of the Beck Depression Inventory-II

    OpenAIRE

    Yuan-Pang Wang; Clarice Gorenstein

    2013-01-01

    To perform a systematic review of the utility of the Beck Depression Inventory for detecting depression in medical settings, this article focuses on the revised version of the scale (Beck Depression Inventory-II), which was reformulated according to the DSM-IV criteria for major depression. We examined relevant investigations with the Beck Depression Inventory-II for measuring depression in medical settings to provide guidelines for practicing clinicians. Considering the inclusion and exclusi...

  6. [Correlations between Beck's suicidal ideation scale, suicidal risk assessment scale RSD and Hamilton's depression rating scale].

    Science.gov (United States)

    Ducher, J-L; Dalery, J

    2008-04-01

    Most of the people who will attempt suicide, talk about it beforehand. Therefore, recognition of suicidal risk is not absolutely impossible. Beck's suicidal ideation scale and Ducher's suicidal risk assessment scale (RSD) are common tools to help practicians in this way. These scales and the Hamilton's depression scale were included in an international multicentric, phase IV, double-blind study, according to two parallel groups who had been administered a fixed dose of fluvoxamin or fluoxetin for six weeks. This allowed examination of the correlations between these scales and the relations, which could possibly exist between suicidal risk, depression and anxiety. (a) Relationships between the Beck's suicidal ideation scale, the suicidal risk assessment scale RSD and Hamilton's depression before treatment. Before treatment, the analysis was conducted with 108 male and female depressive outpatients, aged 18 or over. Results revealed a significant positive correlation (with a Pearson's correlation coefficient r equal to 0.69 and risk pRSD. These scales correlate less consistently with Hamilton's depression (Beck/Hamilton's depression: r=0.34; p=0.0004-RSD/Hamilton's depression: r=0.35; p=0.0002). We observed that the clinical anxiety scale by Snaith is also strongly correlated to these two suicidal risk assessment scales (Beck/CAS: r=0.48; pRSD/CAS: r=0.35; p=0.0005). Besides, the item "suicide" of Hamilton's depression scale accounts for more than a third of the variability of Beck's suicidal ideation scale and the suicidal risk assessment scale RSD. According to these results, the suicidal risk evaluated by these two scales seems to be significantly correlated with anxiety as much as with depression. On the other hand, the Clinical Global Impression is fairly significantly correlated with Beck's suicidal ideation scale (r=0.22; p=0.02), unlike the suicidal risk assessment scale RSD (r=0.42; pRSD and Hamilton's depression under treatment. The follow-up under

  7. The quantum-mechanical basis of an extended Landau-Lifshitz-Gilbert equation for a current-carrying ferromagnetic wire

    OpenAIRE

    Edwards, D. M.; Wessely, O.

    2008-01-01

    An extended Landau-Lifshitz-Gilbert (LLG) equation is introduced to describe the dynamics of inhomogeneous magnetization in a current-carrying wire. The coefficients of all the terms in this equation are calculated quantum-mechanically for a simple model which includes impurity scattering. This is done by comparing the energies and lifetimes of a spin wave calculated from the LLG equation and from the explicit model. Two terms are of particular importance since they describe non-adiabatic spi...

  8. A finite element approximation for the stochastic Landau--Lifshitz--Gilbert equation with multi-dimensional noise

    OpenAIRE

    Goldys, Beniamin; Grotowski, Joseph; Le, Kim-Ngan

    2017-01-01

    We propose an unconditionally convergent linear finite element scheme for the stochastic Landau--Lifshitz--Gilbert (LLG) equation with multi-dimensional noise. By using the Doss-Sussmann technique, we first transform the stochastic LLG equation into a partial differential equation that depends on the solution of the auxiliary equation for the diffusion part. The resulting equation has solutions absolutely continuous with respect to time. We then propose a convergent $\\theta$-linear scheme for...

  9. Gilbert W. Beebe Symposium on 30 Years after the Chernobyl Accident: Current and Future Studies on Radiation Health Effects.

    Science.gov (United States)

    Samet, Jonathan M; de González, Amy Berrington; Dauer, Lawrence T; Hatch, Maureen; Kosti, Ourania; Mettler, Fred A; Satyamitra, Merriline M

    2018-01-01

    This commentary summarizes the presentations and discussions from the 2016 Gilbert W. Beebe symposium "30 years after the Chernobyl accident: Current and future studies on radiation health effects." The symposium was hosted by the National Academies of Sciences, Engineering, and Medicine (the National Academies). The symposium focused on the health consequences of the Chernobyl accident, looking retrospectively at what has been learned and prospectively at potential future discoveries using emerging 21st Century research methodologies.

  10. Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome patients and in healthy subjects.

    Science.gov (United States)

    Rodrigues, Carina; Vieira, Emília; Santos, Rosário; de Carvalho, João; Santos-Silva, Alice; Costa, Elísio; Bronze-da-Rocha, Elsa

    2012-03-15

    The Gilbert syndrome is a benign form of unconjugated hyperbilirubinemia, mainly associated with alterations in UGT1A1 gene. This work investigated the effect of UGT1A1 variants on total bilirubin levels in Gilbert patients (n=45) and healthy controls (n=161). Total bilirubin levels were determined using a colorimetric method; molecular analysis of exons 1-5 and two UGT1A1 promoter regions were performed by direct sequencing and automatic analysis of fragments. Five in silico methods predicted the effect of new identified variants. A significant different allelic distribution, in Gilbert patients and in controls, was found for two promoter polymorphisms. Among patients, 82.2% were homozygous and 17.8% heterozygous for the c.-41_-40dupTA allele; in control group, 9.9% were homozygous and 43.5% heterozygous for this promoter variant, while 46.6% (n=75) presented the [A(TA)6TAA]. For the T>G transition at c.-3279 promoter region, in patients, 86.7% were homozygous and 13.3% heterozygous; in control group, 33.5% were homozygous for the wild type allele, 44.1% were heterozygous and 22.4% homozygous for the mutated allele. The two polymorphisms were in Hardy-Weinberg equilibrium in both groups. Sequencing of UGT1A1 coding region identified nine novel variants, five in patients and four in controls. In silico analysis of these amino acids replacements predicted four of them as benign and three as damaging. In conclusion, we demonstrated that total bilirubin levels are mainly determined by the TA duplication in the TATA-box promoter and by the c.-3279T>G variant. Alterations in the UGT1A1 coding region seem to be associated with increased bilirubin levels, and, therefore, with Gilbert syndrome. Copyright © 2012 Elsevier Inc. All rights reserved.

  11. Donor Safety and Recipient Liver Function After Right-Lobe Liver Transplantation From Living Donors With Gilbert Syndrome.

    Science.gov (United States)

    Kang, W H; Hwang, S; Song, G W; Jung, D H; Kim, K H; Park, G C; Ha, T Y; Ahn, C S; Moon, D B; Yoon, Y I; Shin, M H; Kim, W J; Kim, S H; Lee, S G

    2015-12-01

    Donor safety is the most important aspect in living-donor liver transplantation (LDLT). Gilbert syndrome is an autosomal recessive condition that is a common cause of isolated unconjugated hyperbilirubinemia, and its prevalence is not negligibly low in the general population. This study intended to assess donor safety and recipient liver function after LDLT with the use of right liver grafts from living donors with Gilbert syndrome. Among 2,140 right liver transplantations performed from January 2002 to December 20113 at our institution, we identified 12 living donors (0.6%) who showed a preoperative serum total bilirubin level of ≥2 mg/dL. These donors were clinically diagnosed with Gilbert syndrome. The clinical outcomes of these donors and their recipients were analyzed retrospectively. The mean donor age was 24.6 ± 7.1 years, and 11 donors were male. All subjects met the preoperative evaluation conditions for right liver donation except for the level of unconjugated hyperbilirubinemia. The mean serum total bilirubin level of the donors was 2.23 ± 0.20 mg/dL before and 1.79 ± 0.61 mg/dL 1 year after right liver donation. The preoperative donor direct bilirubin level was 0.43 ± 0.19 mg/dL. The preoperative indocyanine green retention rate at 15 minutes was 8.2 ± 2.8%. All donors and recipients recovered uneventfully and were alive at the time of writing. The recipient serum total bilirubin level was 1.29 ± 0.47 mg/dL 1 year after LDLT. We suggest that LDLT with living donors with Gilbert syndrome can be safely performed, but that a meticulous preoperative evaluation is vital to maximize donor safety. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Attentiography of the Body: correlations between Lisa Nelson and Gilbert Simondon’s work from a narrative fragment

    Directory of Open Access Journals (Sweden)

    Francisco de Assis Gaspar Neto

    2017-01-01

    Full Text Available The paper suggests an interconnection between art and philosophy through approaching the practice of attention upon a section of Tuning Scores, described by the American choreographer and videomaker Lisa Nelson and the individual’s relationship with the environment and with others thought by the French philosopher Gilbert Simondon. Lisa Nelson’s fragment describing the Attentiography of Body is presented in conjunction with Simondon’s characters by covering some interpersonal relationship traits: individuation, individuality, and personality.

  13. Magnetic-field-induced domain-wall motion in permalloy nanowires with modified Gilbert damping

    Science.gov (United States)

    Moore, Thomas A.; Möhrke, Philipp; Heyne, Lutz; Kaldun, Andreas; Kläui, Mathias; Backes, Dirk; Rhensius, Jan; Heyderman, Laura J.; Thiele, Jan-Ulrich; Woltersdorf, Georg; Fraile Rodríguez, Arantxa; Nolting, Frithjof; Menteş, Tevfik O.; Niño, Miguel Á.; Locatelli, Andrea; Potenza, Alessandro; Marchetto, Helder; Cavill, Stuart; Dhesi, Sarnjeet S.

    2010-09-01

    Domain wall (DW) depinning and motion in the viscous regime induced by magnetic fields, are investigated in planar permalloy nanowires in which the Gilbert damping α is tuned in the range 0.008-0.26 by doping with Ho. Real time, spatially resolved magneto-optic Kerr effect measurements yield depinning field distributions and DW mobilities. Depinning occurs at discrete values of the field which are correlated with different metastable DW states and changed by the doping. For α<0.033 , the DW mobilities are smaller than expected while for α≥0.033 , there is agreement between the measured DW mobilities and those predicted by the standard one-dimensional model of field-induced DW motion. Micromagnetic simulations indicate that this is because as α increases, the DW spin structure becomes increasingly rigid. Only when the damping is large can the DW be approximated as a pointlike quasiparticle that exhibits the simple translational motion predicted in the viscous regime. When the damping is small, the DW spin structure undergoes periodic distortions that lead to a velocity reduction. We therefore show that Ho doping of permalloy nanowires enables engineering of the DW depinning and mobility, as well as the extent of the viscous regime.

  14. Nonlinear and chaotic magnetization dynamics near bifurcations of the Landau-Lifshitz-Gilbert equation

    Science.gov (United States)

    Ferona, Aaron M.; Camley, Robert E.

    2017-03-01

    The behavior of a uniformly magnetized domain of ellipsoidal shape subject to a static external field and oscillatory external driving field is analyzed near bifurcation events. The analysis includes the effects of both linear and circularly polarized driving fields and is performed using numerical simulations of the Landau-Lifshitz-Gilbert (LLG) equation. Under a linearly polarized driving field, the LLG equation is a nonautonomous differential equation which can lead to complex magnetization motions, such as bistability, multiperiodic orbits, quasiperiodicity, and chaos. Under a circularly polarized driving field, the LLG equation can be written in autonomous form by transforming to the frame rotating with the driving field. The autonomous nature allows one to perform a fixed-point analysis of the system for select demagnetization factors. Similarities and differences between the driven systems are highlighted through bifurcation diagrams, phase portraits, basins of attraction, and Lyapunov exponents. Magnetization switching, prolonged transients, quasiperiodicity, and chaos are observed with both linearly and circularly polarized driving fields in the magnetic systems investigated.

  15. Informational Ontology: The Meaning of Gilbert Simondon’s Concept of Individuation

    Directory of Open Access Journals (Sweden)

    Andrew Iliadis

    2013-09-01

    Full Text Available The French philosopher Gilbert Simondon (1924-1989 was the first true philosopher of information, yet he remains relatively unknown outside of his native France. This situation is curious, given the warm reception his work has received from a small group of internationally renowned thinkers. Simondon’s lifelong project was to expound the appearance of what I call an “informational ontology,” a subject that deserves to be addresses at length. This article limits itself by focusing on three aspects of Simondon’s philosophy of information. First, it situates Simondon within the French intellectual scene in post-World War II Europe to get sense of his cultural milieu. Second, it positions Simondon’s work in the context of the American cybernetic tradition from which it emerged. Finally, it offers an exegesis of Simondon’s informational ontology, a radically new materialism that stands to change contemporary debates surrounding issues related to information, communication, and technology.

  16. APC-PC Combined Scheme in Gilbert Two State Model: Proposal and Study

    Science.gov (United States)

    Bulo, Yaka; Saring, Yang; Bhunia, Chandan Tilak

    2017-04-01

    In an automatic repeat request (ARQ) scheme, a packet is retransmitted if it gets corrupted due to transmission errors caused by the channel. However, an erroneous packet may contain both erroneous bits and correct bits and hence it may still contain useful information. The receiver may be able to combine this information from multiple erroneous copies to recover the correct packet. Packet combining (PC) is a simple and elegant scheme of error correction in transmitted packet, in which two received copies are XORed to obtain the bit location of erroneous bits. Thereafter, the packet is corrected by bit inversion of bit located as erroneous. Aggressive packet combining (APC) is a logic extension of PC primarily designed for wireless communication with objective of correcting error with low latency. PC offers higher throughput than APC, but PC does not correct double bit errors if occur in same bit location of erroneous copies of the packet. A hybrid technique is proposed to utilize the advantages of both APC and PC while attempting to remove the limitation of both. In the proposed technique, applications of APC-PC on Gilbert two state model has been studied. The simulation results show that the proposed technique offers better throughput than the conventional APC and lesser packet error rate than PC scheme.

  17. Gilbert damping constant of FePd alloy thin films estimated by broadband ferromagnetic resonance

    Directory of Open Access Journals (Sweden)

    Kawai T.

    2014-07-01

    Full Text Available Magnetic relaxation of FePd alloy epitaxial thin films with very flat surfaces prepared on MgO(001 substrate are measured by in-plane broadband ferromagnetic resonance (FMR. Magnetic relaxation is investigated as Δω for FMR absorption peak by frequency sweep measurements. ΔH is calculated by using the measured Δω. Gilbert damping constant, α, is estimated by employing a straight line fitting of the resonant frequency dependence of ΔH. The α value for an FePd film deposited at 200 ˚C, which shows disordered A1 structure, is 0.010 and ΔH0, which is frequency independent part of ΔH, is 10 Oe. The α value for a film annealed at 400 ˚C, which shows partially L10 ordered structure (S=0.32, is 0.013, which is slightly larger than that for the disorder A1 structure film. However, ΔH0 for the annealed film is 85 Oe, which is much larger than that for the film with disordered structure. The results show that the magnetic relaxation of the 400 ˚C annealed film is mainly dominated by ΔH0, which is related with magnetic in-homogeneity caused by the appearance of perpendicular anisotropy of partially ordered phase.

  18. Low Gilbert damping in Co2FeSi and Fe2CoSi films

    Science.gov (United States)

    Sterwerf, Christian; Paul, Soumalya; Khodadadi, Behrouz; Meinert, Markus; Schmalhorst, Jan-Michael; Buchmeier, Mathias; Mewes, Claudia K. A.; Mewes, Tim; Reiss, Günter

    2016-08-01

    Thin highly textured Fe1+xCo2-xSi (0 ≤ x ≤ 1) films were prepared on MgO (001) substrates by magnetron co-sputtering. Magneto-optic Kerr effect (MOKE) and ferromagnetic resonance (FMR) measurements were used to investigate the composition dependence of the magnetization, the magnetic anisotropy, the gyromagnetic ratio, and the relaxation of the films. Both MOKE and FMR measurements reveal a pronounced fourfold anisotropy for all films. In addition, we found a strong influence of the stoichiometry on the anisotropy as the cubic anisotropy strongly increases with increasing Fe concentration. The gyromagnetic ratio is only weakly dependent on the composition. We find low Gilbert damping parameters for all films with values down to 0.0012 ±0.00010.0007 for Fe1.75Co1.25Si. The effective damping parameter for Co2FeSi is found to be 0.0018 ±0.00040.0034 . We also find a pronounced anisotropic relaxation, which indicates significant contributions of two-magnon scattering processes that is strongest along the easy axes of the films. This makes thin Fe1+xCo2-xSi films ideal materials for the application in spin transfer-torque magnetic RAM (STT-MRAM) devices.

  19. Magnetization dynamics: path-integral formalism for the stochastic Landau-Lifshitz-Gilbert equation

    Science.gov (United States)

    Aron, Camille; Barci, Daniel G.; Cugliandolo, Leticia F.; González Arenas, Zochil; Lozano, Gustavo S.

    2014-09-01

    We construct a path-integral representation of the generating functional for the dissipative dynamics of a classical magnetic moment as described by the stochastic generalization of the Landau-Lifshitz-Gilbert equation proposed by Brown (1963 Phys. Rev. 130 1677), with the possible addition of spin-torque terms. In the process of constructing this functional in the Cartesian coordinate system, we critically revisit this stochastic equation. We present it in a form that accommodates for any discretization scheme thanks to the inclusion of a drift term. The generalized equation ensures the conservation of the magnetization modulus and the approach to the Gibbs-Boltzmann equilibrium in the absence of non-potential and time-dependent forces. The drift term vanishes only if the mid-point Stratonovich prescription is used. We next reset the problem in the more natural spherical coordinate system. We show that the noise transforms non-trivially to spherical coordinates acquiring a non-vanishing mean value in this coordinate system, a fact that has been often overlooked in the literature. We next construct the generating functional formalism in this system of coordinates for any discretization prescription. The functional formalism in Cartesian or spherical coordinates should serve as a starting point to study different aspects of the out-of-equilibrium dynamics of magnets. Extensions to colored noise, micro-magnetism and disordered problems are straightforward.

  20. Ideias sobre progresso técnico em Vilém Flusser e Gilbert Simondon

    Directory of Open Access Journals (Sweden)

    Angélica Beatriz Castro Guimarães

    2013-07-01

    Full Text Available http://dx.doi.org/10.5007/1807-9288.2013v9n1p172   Esse artigo apresenta algumas ideias sobre o progresso técnico e a relação humano-máquina em Vilém Flusser e Gilbert Simondon. Os dois autores apresentam conceitos bem diferentes sobre a técnica, mas ambos projetam seus argumentos para a situação de intensificação técnica que ocorre a partir de meados do século XX. Simondon pensa a geração de objetos técnicos como modulação de intensidades. Flusser concebe o progresso técnico como uma escalada de abstração que não se encerra como modelo linear e acumulativo. Os dois autores pensam a situação de desorientação diante da aparente intencionalidade dos objetos técnicos. A partir dos conceitos propostos é possível pensar sobre a modulação do fluxo técnico pela arte no campo da sensibilidade.

  1. Classifying College Students as Depressed or Nondepressed Using the Beck Depression Inventory: An Empirical Analysis.

    Science.gov (United States)

    Hatzenbuehler, Linda C.; And Others

    1983-01-01

    Assessed the consistency of classification of depression in college students in two studies. The stability of the Beck Depression Inventory was tested after one day, one week, and using subsequent responses for subjects retested the same day. Results showed repeated administration resulted in a decline of high scores. (JAC)

  2. Integrating Beck's cognitive model and the response style theory in an adolescent sample.

    Science.gov (United States)

    Winkeljohn Black, Stephanie; Pössel, Patrick

    2015-01-01

    Depression becomes more prevalent as individuals progress from childhood to adulthood. Thus, empirically supported and popular cognitive vulnerability theories to explain depression in adulthood have begun to be tested in younger age groups, particularly adolescence, a time of significant cognitive development. Beck's cognitive theory and the response style theory are well known, empirically supported theories of depression. The current, two-wave longitudinal study (N = 462; mean age = 16.01 years; SD = 0.69; 63.9% female) tested various proposed integrative models of Beck's cognitive theory and the response style theory, as well as the original theories themselves, to determine if and how these cognitive vulnerabilities begin to intertwine in adolescence. Of the integrative models tested-all with structural equation modeling in AMOS 21-the best-fitting integrative model was a moderation model wherein schemata influenced rumination, and rumination then influenced other cognitive variables in Beck's model. Findings revealed that this integrated model fit the data better than the response style theory and explained 1.2% more variance in depressive symptoms. Additionally, multigroup analyses comparing the fit of the best-fitting integrated model across adolescents with clinical and subclinical depressive symptoms revealed that the model was not stable between these two subsamples. However, of the hypotheses relevant to the integrative model, only 1 of the 18 associations was significantly different between the clinical and subclinical samples. Regardless, the integrated model was not superior to the more parsimonious model from Beck's cognitive theory. Implications and limitations are discussed.

  3. A Psychometric Investigation of the Standard and Short Form Beck Depression Inventory.

    Science.gov (United States)

    Reynolds, William M.; Gould, Jonathan W.

    1981-01-01

    Investigated the reliability, validity, and factor structure of the standard 21-item and short 13-item forms of the Beck Depression Inventory. The sample consisted of 163 participants in a methadone maintenance program. Results support the use of the short form as a reliable and valid brief screening measure of depression. (Author)

  4. Measurement Invariance and Latent Mean Differences of the Beck Depression Inventory II across Gender Groups

    Science.gov (United States)

    Wu, Pei-Chen

    2010-01-01

    This study examined measurement invariance (i.e., configural invariance, metric invariance, scalar invariance) of the Chinese version of Beck Depression Inventory II (BDI-II-C) across college males and females and compared gender differences on depression at the latent factor mean level. Two samples composed of 402 male college students and 595…

  5. Longitudinal Stability of the Beck Depression Inventory II: A Latent Trait-State-Occasion Model

    Science.gov (United States)

    Wu, Pei-Chen

    2016-01-01

    In a six-wave longitudinal study with two cohorts (660 adolescents and 630 young adults), this study investigated the longitudinal stability of the Beck Depression Inventory II (BDI-II) using the Trait-State-Occasion (TSO) model. The results revealed that the full TSO model was the best fitting representation of the depression measured by the…

  6. Depression as Measured by the Beck Depression Inventory-II among Injecting Drug Users

    Science.gov (United States)

    Johnson, Mark E.; Neal, David B.; Brems, Christiane; Fisher, Dennis G.

    2006-01-01

    This study conducts a confirmatory factor analysis of the Beck Depression Inventory-II (BDI-II) with a sample of 598 individuals who reported recent injecting drug use. Findings indicate that out of four models tested, the best model for this sample is a three-factor solution (somatic, affective, and cognitive) previously reported by Buckley,…

  7. The Beck Depression Inventory, Second Edition (BDI-II): A Cross-Sample Structural Analysis

    Science.gov (United States)

    Strunk, Kamden K.; Lane, Forrest C.

    2017-01-01

    A common concern about the Beck Depression Inventory, Second edition (BDI-II) among researchers in the area of depression has long been the single-factor scoring scheme. Methods exist for making cross-sample comparisons of latent structure but tend to rely on estimation methods that can be imprecise and unnecessarily complex. This study presents a…

  8. Rasch Rating Scale Modeling of the Korean Version of the Beck Depression Inventory

    Science.gov (United States)

    Hong, Sehee; Wong, Eunice C.

    2005-01-01

    The Beck Depression Inventory (BDI) is one of the most frequently used instruments in the study of depression both within and outside of the United States. Though developed primarily with European American clinical populations, the BDI has been applied in nonclinical and non-Western samples. To determine whether such a practice is warranted, the…

  9. Validating the Beck Depression Inventory-II in Indonesia's general population and coronary heart disease patients

    NARCIS (Netherlands)

    Ginting, H.; Näring, G.W.B.; Veld, W.M. van der; Srisayekti, W.; Becker, E.S.

    2013-01-01

    This study assesses the validity and determines the cut-off point for the Beck Depression Inventory-II (the BDI-II) among Indonesians. The Indonesian version of the BDI-II (the Indo BDI-II) was administered to 720 healthy individuals from the general population, 215 Coronary Heart Disease (CHD)

  10. Validation of the Urdu Translation of the Beck Scale for Suicide Ideation

    Science.gov (United States)

    Ayub, Nailah

    2008-01-01

    This study aimed at developing an Urdu version of the Beck Scale for Suicide Ideation (BSI) for use with Pakistani adolescents and young adults. For this purpose, the English BSI was translated into Urdu and tested for psychometric properties. The analyses were carried out with data from a sample of 904 adolescents and young adults from eight…

  11. Effects of chondroitin sulfate and glucosamine in adult patients with Kaschin-Beck disease

    DEFF Research Database (Denmark)

    Zhang, Ya-xu; Dong, Wei; Liu, Hui

    2010-01-01

    The purpose is to investigate the effects of chondroitin sulfate and glucosamine on adult patients with Kaschin-Beck disease (KBD). A total of 80 patients, aged over 40 years, were randomized into two groups receiving either 1,600 mg oral mixture of chondroitin sulfate and glucosamine or placebo...... evidence for therapeutic drugs in adult patients with KBD....

  12. Psychometric Properties of the Beck Depression Inventories When Used with an Elderly Population.

    Science.gov (United States)

    Watkins, Arleen J.; Kligman, Evan

    The Beck Depression Inventory (BDI) is a self-reported inventory tapping current feelings only. A short form was published in 1972 consisting of 13 items from the original BDI, called the BDI-SF. In 1978 the original version was modified to eliminate double negative statements and alternative ways of asking the same question and then referred to…

  13. Meta-Analysis of the English Version of the Beck Depression Inventory-Second Edition

    Science.gov (United States)

    Erford, Bradley T.; Johnson, Erin; Bardoshi, Gerta

    2016-01-01

    This meta-analysis reviewed 144 studies from 1996 to 2013 using the Beck Depression Inventory-Second Edition. Internal consistency was 0.89 and test-retest reliability 0.75. Convergent comparisons were robust across 43 depression instruments. Structural validity supported both one- and two-factor solutions and diagnostic accuracy varied according…

  14. Confirmatory Factor Analysis of the Beck Depression Inventory-II in Bariatric Surgery Candidates

    Science.gov (United States)

    Hall, Brian J.; Hood, Megan M.; Nackers, Lisa M.; Azarbad, Leila; Ivan, Iulia; Corsica, Joyce

    2013-01-01

    Screening for depression is an integral part of psychological evaluations conducted prior to bariatric surgery. The Beck Depression Inventory-II (BDI-II) is the most commonly used measure of depression in these treatment evaluations. The reliability and validity of the BDI-II has not yet been evaluated within bariatric surgery-seeking samples,…

  15. The Latent Symptom Structure of the Beck Depression Inventory-II in Outpatients with Major Depression

    Science.gov (United States)

    Quilty, Lena C.; Zhang, K. Anne; Bagby, R. Michael

    2010-01-01

    The Beck Depression Inventory-II (BDI-II) is a self-report instrument frequently used in clinical and research settings to assess depression severity. Although investigators have examined the factor structure of the BDI-II, a clear consensus on the best fitting model has not yet emerged, resulting in different recommendations regarding how to best…

  16. Comparison of inguinal hernia repairs performed with lichtenstein, rutkow-robbins, and gilbert double layer graft methods.

    Science.gov (United States)

    Karaca, A Serdar; Ersoy, Omer Faik; Ozkan, Namik; Yerdel, Mehmet Ali

    2015-02-01

    Tension-free repairs are performed commonly in inguinal hernia operations. The objective of the present study is to compare the outcomes of three different tension-free repair methods known as Lichtenstein, Rutkow-Robbins, and Gilbert double layer. One-hundred and fifty patients diagnosed with inguinal hernia were randomly split into three groups. The comparisons across groups were carried out in terms of operation length, postoperative pain, femoral vein flow velocity, early and late complications, recurrence rates, length of hospital stay, time required to return to work, and cost analysis. No difference was found between the groups regarding age, gender, type and classification of hernia, postoperative pain, and late complications (p > 0.05). Operation length was 53.70 ± 12.32 min in the Lichtenstein group, 44.29 ± 12.37 min in the Rutkow-Robbins group, and 45.21 ± 14.36 min in the Gilbert group (p Robbins group, and 16.02 ± 3.19 and 15.52 ± 3.358 cm/s for the Gilbert group, respectively. Statistical difference was found between all the groups (p Robbins group, and three (6 %) patients of Gilbert group (p = 0.033). Cost analysis produced the following results for Lichtenstein, Rutkow-Robbins, and Gilbert groups: US $157.94 ± 50.05, $481.57 ± 11.32, and $501.51 ± 73.59, respectively (p < 0.001). Lichtenstein operation was found to be more advantageous compared with the other techniques in terms of cost analysis as well as having unaffected femoral blood flow. Therefore, we believe that Lichtenstein repair is still the most appropriate surgical option in patients diagnosed with inguinal hernia.

  17. Sociedade de risco: avanços e limites da teoria de Ulrich Beck / Risk society: advances and limits of Ulrich Beck´s theory

    OpenAIRE

    Falbo, Ricardo Nery; Keller, Rene José

    2015-01-01

    Trabalho enviado em 17 de outubro de 2015. Aceito em 22 de outubro de 2015DOI: http://dx.doi.org/10.12957/rqi.2015Resumo O principal objetivo deste trabalho consiste na análise dos avanços e limites da teoria do risco e da teoria da sociedade do risco de Ulrich Beck. A imprevisibilidade e magnitude que caracterizam as catástrofes da natureza e as incertezas e medos que elas produzem têm desafiado a “modernidade reflexiva” e levado cientistas de diversas áreas do conhecimento à procura de expl...

  18. The Beck Depression Inventory-II: Testing for Measurement Equivalence and Factor Mean Differences across Hong Kong and American Adolescents

    Science.gov (United States)

    Byrne, Barbara M.; Stewart, Sunita M.; Kennard, Betsy D.; Lee, Peter W. H.

    2007-01-01

    Working within the framework of a confirmatory factor analytic (CFA) model, this study adds another dimension to construct validation of both the Beck Depression Inventory-II (BDI-II; Beck, Steer, & Brown, 1996) and a Chinese version of the BDI-II (C-BDI-II; Chinese Behavioral Sciences Society, 2000). Specifically, we tested for measurement…

  19. Relationships between the Underlying Constructs of the Beck Depression Inventory and the Center for Epidemiological Studies Depression Scale.

    Science.gov (United States)

    Skorikov, Vladimir B.; Vandervoort, Debra J.

    2003-01-01

    Examined the relationships between the constructs of depression as measured by the Center for Epidemiological Studies Depression Scale (CES-D) and the revised Beck Depression Inventory (BDI; Beck and others, 1979) in 261 college students. Findings suggest the BDI and CES-D measure different aspects of depression and should not be used…

  20. Gilbert syndrome in patients with type 1 diabetes-Prevalence, glycemic control, and microalbuminuria.

    Science.gov (United States)

    Singer, Sigal; Pilpel, Nurit; Pinhas-Hamiel, Orit

    2017-01-17

    Gilbert syndrome (GS) is a common hereditary condition, characterized by intermittent unconjugated hyperbilirubinemia. In adults with type 2 diabetes and GS, a markedly lower prevalence of nephropathy was documented, suggesting a beneficial effect of hyperbilirubinemia. We investigated the prevalence of GS among individuals with type 1 diabetes mellitus (T1DM), and the prevalence of microalbuminuria. The prevalence of GS was assessed in 401 (204 female) patients with T1DM, median age 21.0 years, (interquartile range [IQR], 15.7-27.9), median disease duration 10.8 years (IQR, 5.7-15.8); and was compared with GS prevalence in 181 children (control). The prevalence of microalbuminuria was assessed in patients with T1DM and GS (group I) and compared with that of patients with T1DM alone (group II), in a ratio of 1:2 matched by gender, age, and duration of diabetes. The prevalence of GS in TIDM patients was significantly higher than in the control group (10.7% vs 3.3% respectively, p = .004), with no gender difference. Patients with T1DM and GS had significantly lower HbA1c levels than did those with T1DM alone 7.3 ± 1.2 vs 7.9 ± 1.3% respectively (56 ± 13 vs 63 ± 14 mmol/mol), p = .02. The rate of microalbuminuria was 14.0% vs 11.0% for patients with T1DM and GS, compared with those with T1DM alone (p = .6). The occurrence of GS was 3-fold higher among individuals with T1DM than in a healthy control group. Despite better glycemic control, the rate of microalbuminuria was similar among young individuals with T1DM and GS, and those with T1DM alone, suggesting no protective value to elevated bilirubin. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome.

    Science.gov (United States)

    Boon, Ai-Ching; Hawkins, Clare L; Bisht, Kavita; Coombes, Jeff S; Bakrania, Bhavisha; Wagner, Karl-Heinz; Bulmer, Andrew C

    2012-05-15

    A protective association between bilirubin and atherosclerosis/ischemic heart disease clearly exists in vivo. However, the relationship between bilirubin and in vivo oxidative stress parameters in a clinical population remains poorly described. The aim of this study was to assess whether persons expressing Gilbert syndrome (GS; i.e., unconjugated hyperbilirubinemia) are protected from thiol oxidation and to determine if this, in addition to their improved lipoprotein profile, could explain reduced oxidized low-density lipoprotein (oxLDL) status in them. Forty-four matched GS and control subjects were recruited and blood was prepared for the analysis of lipid profile and multiple plasma antioxidants and measures of oxidative stress. GS subjects possessed elevated plasma reduced thiol (8.03±1.09 versus 6.75±1.39 nmol/mg protein; P40 μM bilirubin versus controls (<17.1 μmol/L; P<0.05). Furthermore, absolute oxLDL concentrations were significantly lower in GS subjects (P<0.05). Forward stepwise regression analysis revealed that bilirubin was associated with increased GSH:GSSG ratio and reduced thiol concentrations, which, in addition to reduced circulating LDL, probably decreased oxLDL concentrations within the cohort. In addition, a marked reduction in total cholesterol concentrations in hyperbilirubinemic Gunn rats is presented (Gunn 0.57±0.09 versus control 1.69±0.40 mmol/L; P<0.001), arguing for a novel role for bilirubin in modulating lipid status in vivo. These findings implicate the physiological importance of bilirubin in protecting from atherosclerosis by reducing thiol and subsequent lipoprotein oxidation, in addition to reducing circulating LDL concentrations. Copyright © 2012 Elsevier Inc. All rights reserved.

  2. Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels.

    Science.gov (United States)

    Yüce, Süleyman; Cüre, Erkan; Çiçek, Yüksel; Cumhur Cüre, Medine; Yılmaz, Arif; Kızılkaya, Bayram

    2015-10-01

    Gilbert's syndrome (GS) is an autosomal recessive disease that is characterized by an increase in indirect bilirubin (IB). The incidence of atherosclerotic heart disease is decreased in GS. This study aimed to investigate the relation between pulse wave velocity (PWV) and the presence of GS. The study included 58 GS patients (32 females, age; 27.12 ± 7.27 years, 26 males, age; 26.63 ± 5.84 years) admitted to the internal medicine clinic of the hospital. The control group included 58 healthy individuals (35 females [27.33 ± 8.06 years old, p=0.716] and 23 males [27.38 ± 6.91 years old, p=0.923]). PWV of both groups was measured from the right carotid and femoral arteries. Mean age of the GS group was 26.03 ± 8.22 years, while that of the healthy group was 26.60 ± 5.84 years. The GS group's diastolic blood pressure and PWV were significantly lower than those of the control group: 67.76 ± 8.59 mmHg vs 71.72 ± 7.28 mmHg; p=0.008, and 5.63 ± 1.12 m/s vs 6.18 ± 1.22 m/s; p=0.014 respectively. The GS group's high density lipoprotein (HDL) level was significantly higher than that of the control group: 1.4 ± 0.3 mmol/L vs 1.2 ± 0.3 mmol/L, p=0.029. This study found PWV among GS patients to be lower than that among non-smoking and aged-matched healthy controls.

  3. Genetic susceptibility to Gilbert's syndrome in a valencian population; efficacy of the fasting test.

    Science.gov (United States)

    Torres, A K; Escartín, N; Monzó, C; Guzmán, C; Ferrer, I; González-Muñoz, C; Peña, P; Monzó, V; Marcaida, G; Rodríguez-López, R

    To describe the populational distribution of the UGT1A1*28 variant (genetic variant code rs8175347) located in the promotor of the UGT gene and correlate its genotypes with the results of the fasting test, as well as its relationship with the biochemical disorder of Gilbert's syndrome (GS) in a Valencian population. We studied the prevalence of the genotypes (TA) 6/6 (TA) 6/7 and (TA) 7/7 of the deleterious variant rs8175347 in 144 patients with hyperbilirubinemia, 38 of whom had previously undergone the fasting test to diagnose GS, and in 150 control patients. By analysing the genomic region of the TATA box of the UGT1A1 gene promotor using Sanger sequencing, we established the correlation between the rs8175347 genotypes and the fasting test results and with the patients' biochemical disorders. The rate of heterozygosity of allele (TA) 7 in the control population was 32% and increased to 87.59% among the patients with suspected GS. The rate of genotype TA 7/7 was 81.94% among the patients with hyperbilirubinemia, compared with 11.33% in the control patients. The fasting test showed a 15.79% rate of false negatives and a 5.26% rate of false positives. The high frequency of allele (TA) 7 among the Valencian control population, almost double the 5% reported for European control patients, confirms the high rate of GS reported in the Spanish population, without observing significant differences between the geographical ends of the country. The efficacy and reliability of the fasting test for the diagnosis of GS is questionable. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

  4. ‘Speaking Kleinian’: Susan Isaacs as Ursula Wise and the Inter-War Popularisation of Psychoanalysis

    Science.gov (United States)

    Shapira, Michal

    2017-01-01

    How did the complex concepts of psychoanalysis become popular in early twentieth-century Britain? This article examines the contribution of educator and psychoanalyst Susan Isaacs (1885–1948) to this process, as well as her role as a female expert in the intellectual and medical history of this period. Isaacs was one of the most influential British psychologists of the inter-war era, yet historical research on her work is still limited. The article focuses on her writing as ‘Ursula Wise’, answering the questions of parents and nursery nurses in the popular journal Nursery World, from 1929 to 1936. Researched in depth for the first time, Isaacs’ important magazine columns reveal that her writing was instrumental in disseminating the work of psychoanalyst Melanie Klein in Britain. Moreover, Isaacs’ powerful rebuttals to behaviourist, disciplinarian parenting methods helped shift the focus of caregivers to the child’s perspective, encouraging them to acknowledge children as independent subjects and future democratic citizens. Like other early psychoanalysts, Isaacs was not an elitist; she was in fact committed to disseminating her ideas as broadly as possible. Isaacs taught British parents and child caregivers to ‘speak Kleinian’, translating Klein’s intellectual ideas into ordinary language and thus enabling their swift integration into popular discourse. PMID:28901872

  5. Orobanche tunetana G. Beck (Orobanchaceae, especie nueva para el continente europeo

    Directory of Open Access Journals (Sweden)

    Pujadas, Antonio

    1997-12-01

    Full Text Available The presence of Orobanche tunetana G. Beck in the south-eastern part of the Iberian Península is noted. An original ilhistrabon, the chorology and the description of the Iberian specimens are given. The differences are also analysed between this species and O. caesia Rchb.. with which it shows certain similarities.Se indica la presencia de Orobanche tunetana G. Beck en el sudeste de la Península Ibérica. Aportamos un icono original, la corología y la descripción de los ejemplares ibéricos. Se analizan las diferencias con O. caesia Rchb., con el que presenta ciertas semejanzas.

  6. Beck Anxiety Inventory: psychometric characteristics in a sample from the clinical Spanish population.

    Science.gov (United States)

    Vázquez Morejón, Antonio J; Vázquez-Morejón Jiménez, Raquel; Zanin, Gloria Bellido

    2014-10-28

    Even though the Beck Anxiety Inventory (BAI) is one of the most popular instruments to assess anxiety today, only limited data is available about its psychometric characteristics and normative values in clinical Spanish populations. A study was conducted to test the psychometric characteristics of a Spanish adaptation of the Beck Anxiety Inventory (BAI) in a sample of 918 outpatients being treated at a community mental health center in Spain. Results confirmed the adaptation's high internal consistency (∝ = .91), substantial test-retest reliability at 8-10 weeks (r = .84, p Anxiety (r = .86, p Phobic Anxiety (r = .63, p < .01) dimensions of the SCL-90-R, and with the Anxious Thoughts Inventory (r = .57, p < .01). Gender differences in BAI scores did occur, so normative values appear separately for each gender.

  7. Aaron Temkin BECK: After Cricitical Thinking to A Creative Psychotherapy Theory

    OpenAIRE

    Mehmet DÝNÇ

    2012-01-01

    There is growing interest in the cognitive psychotherapy all around the world including Turkey. According to American Institute of cognitive Therapy; cognitive psychotherapy is the fastest growing and most rigorously studied kind of talk therapy and it is practiced around the world, taking hold in places from the Middle East to Japan. Cognitive psychotherapy was designed first by Aaron Temkin Beck in 1950’s. He has published over 450 articles and authored or co-authored seventeen books a...

  8. Aaron Temkin BECK: After Cricitical Thinking to A Creative Psychotherapy Theory

    OpenAIRE

    DİNÇ, Mehmet

    2012-01-01

    There is growing interest in the cognitive psychotherapy all around the world including Turkey. According to American Institute of Cognitive Therapy; cognitive psychotherapy is the fastest growing and most rigorously studied kind of talk therapy and it is practiced around the world, taking hold in places from the Middle East to Japan. Cognitive psychotherapy was designed first by Aaron Temkin Beck in 1950’s. He has published over 450 articles and authored or co-authored sevent...

  9. Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome

    Directory of Open Access Journals (Sweden)

    Sato Hiroshi

    2010-06-01

    Full Text Available Abstract Background Gilbert syndrome is caused by defects in bilirubin UDP-glucuronosyltransferase (UGT1A1. The most common variation believed to be involved is A(TA7TAA. Although several polymorphisms have been found to link with A(TA7TAA, the combined effect of regulatory polymorphisms in the development of Gilbert syndrome remains unclear. Methods In an analysis of 15 patients and 60 normal subjects, we detected 14 polymorphisms and nine haplotypes in the regulatory region. We classified the 4-kbp regulatory region of the patients into: the TATA box including A(TA7TAA; a phenobarbital responsive enhancer module including c.-3275T>G; and a region including other ten linked polymorphisms. The effect on transcription of these polymorphisms was studied. Results All haplotypes with A(TA7TAA had c.-3275T>G and additional polymorphisms. In an in-vitro expression study of the 4-kbp regulatory region, A(TA7TAA alone did not significantly reduce transcription. In contrast, c.-3275T>G reduced transcription to 69% of that of wild type, and the linked polymorphisms reduced transcription to 88% of wild type. Transcription of the typical regulatory region of the patients was 56% of wild type. Co-expression of constitutive androstane receptor (CAR increased the transcription of wild type by a factor of 4.3. Each polymorphism by itself did not reduce transcription to the level of the patients, however, even in the presence of CAR. Conclusions These results imply that co-operation of A(TA7TAA, c.-3275T>G and the linked polymorphisms is necessary in causing Gilbert syndrome.

  10. Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome.

    Science.gov (United States)

    Matsui, Katsuyuki; Maruo, Yoshihiro; Sato, Hiroshi; Takeuchi, Yoshihiro

    2010-06-08

    Gilbert syndrome is caused by defects in bilirubin UDP-glucuronosyltransferase (UGT1A1). The most common variation believed to be involved is A(TA)7TAA. Although several polymorphisms have been found to link with A(TA)7TAA, the combined effect of regulatory polymorphisms in the development of Gilbert syndrome remains unclear. In an analysis of 15 patients and 60 normal subjects, we detected 14 polymorphisms and nine haplotypes in the regulatory region. We classified the 4-kbp regulatory region of the patients into: the TATA box including A(TA)7TAA; a phenobarbital responsive enhancer module including c.-3275T>G; and a region including other ten linked polymorphisms. The effect on transcription of these polymorphisms was studied. All haplotypes with A(TA)7TAA had c.-3275T>G and additional polymorphisms. In an in-vitro expression study of the 4-kbp regulatory region, A(TA)7TAA alone did not significantly reduce transcription. In contrast, c.-3275T>G reduced transcription to 69% of that of wild type, and the linked polymorphisms reduced transcription to 88% of wild type. Transcription of the typical regulatory region of the patients was 56% of wild type. Co-expression of constitutive androstane receptor (CAR) increased the transcription of wild type by a factor of 4.3. Each polymorphism by itself did not reduce transcription to the level of the patients, however, even in the presence of CAR. These results imply that co-operation of A(TA)7TAA, c.-3275T>G and the linked polymorphisms is necessary in causing Gilbert syndrome.

  11. Assessment of depression in medical patients: a systematic review of the utility of the Beck Depression Inventory-II.

    Science.gov (United States)

    Wang, Yuan-Pang; Gorenstein, Clarice

    2013-09-01

    To perform a systematic review of the utility of the Beck Depression Inventory for detecting depression in medical settings, this article focuses on the revised version of the scale (Beck Depression Inventory-II), which was reformulated according to the DSM-IV criteria for major depression. We examined relevant investigations with the Beck Depression Inventory-II for measuring depression in medical settings to provide guidelines for practicing clinicians. Considering the inclusion and exclusion criteria seventy articles were retained. Validation studies of the Beck Depression Inventory-II, in both primary care and hospital settings, were found for clinics of cardiology, neurology, obstetrics, brain injury, nephrology, chronic pain, chronic fatigue, oncology, and infectious disease. The Beck Depression Inventory-II showed high reliability and good correlation with measures of depression and anxiety. Its threshold for detecting depression varied according to the type of patients, suggesting the need for adjusted cut-off points. The somatic and cognitive-affective dimension described the latent structure of the instrument. The Beck Depression Inventory-II can be easily adapted in most clinical conditions for detecting major depression and recommending an appropriate intervention. Although this scale represents a sound path for detecting depression in patients with medical conditions, the clinician should seek evidence for how to interpret the score before using the Beck Depression Inventory-II to make clinical decisions.

  12. Aaron T. Beck's drawings and the psychoanalytic origin story of cognitive therapy.

    Science.gov (United States)

    Rosner, Rachael I

    2012-02-01

    In this essay the author challenges the standard origin story of cognitive therapy, namely, that its founder Aaron T. Beck broke with psychoanalysis to pursue a more pragmatic, parsimonious, and experimentalist cognitive model. It is true that Beck broke with psychoanalysis in large measure as a result of his experimental disconfirmation of key psychoanalytic ideas. His new school of cognitive therapy brought the experimental ethos into every corner of psychological life, extending outward into the largest multisite randomized controlled studies of psychotherapy ever attempted and inward into the deepest recesses of our private worlds. But newly discovered hand-sketched drawings from 1964 of the schema, a conceptual centerpiece of cognitive therapy, as well as unpublished personal correspondence show that Beck continued to think psychoanalytically even after he broke with psychoanalysis. The drawings urge us to consider an origin story much more complex than the one of inherited tradition. This new, multifaceted origin story of cognitive therapy reaches beyond sectarian disagreements and speaks to a broader understanding of the theoretical underpinnings of cognitive therapy.

  13. Testing three different sequential mediational interpretations of Beck's cognitive model of the development of depression.

    Science.gov (United States)

    Pössel, Patrick; Black, Stephanie Winkeljohn

    2014-01-01

    This study tested and compared three sequential interpretations of Beck's cognitive model of the development of depression (1996). The causal mediational interpretation identifies dysfunctional attitudes as most distal to depressive symptoms, followed by cognitive distortions, the cognitive triad, and negative automatic thoughts, with each construct successively more proximal to depressive symptoms. By contrast, the symptom model reverses the causal chain with negative automatic thoughts as the most proximal consequence and dysfunctional attitudes as the most distal consequence of depression. The bidirectional model merges both interpretations into one model. Previous studies on sequential interpretations of Beck's model have not included cognitive distortions or the cognitive triad and did not test the bidirectional model finding contradictory empirical evidence for the sequential order. In the 3-wave longitudinal study, 308 German university students without clinically significant depressive symptoms (245 female, average age: 23.69 years) completed self-report questionnaires measuring their dysfunctional attitudes, cognitive distortions, cognitive triad, negative automatic thoughts, and depressive symptoms. The bidirectional model with partial mediation fit the data best and cognitive distortions mediated the relationship between dysfunctional attitudes and negative automatic thoughts and vice versa. The findings have important consequences for the prevention of depression. Prevention programs may want to focus on cognitive distortions, the only construct in Beck's model that influences every other construct in the model. © 2013 Wiley Periodicals, Inc.

  14. Reflections on family in the writings o f Józef Beck. Research results

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    AGNIESZKA SUSKA

    2017-10-01

    Full Text Available Issues connected with the families of the Second Republic are discussed in the article. The problem is addressed form the perspective of the writings of Józef Beck, a prominent politician and respected local official. There is a rich legacy of the opinions and aspirations of Józef Beck contained in newspapers, brochures and books. Issues conceming family are often addressed in these writings on diverse subjects. The views can be divided into two groups, with those in the first one directly addressing family issues and those in the second one implying indirect relation to family issues. The picture of the family to be found in the publications of Józef Alojzy Beck is a collection of issues and problems crucial to the family which may be greatly influenced by local govemment. Initiative in the areas of public healthcare, school education and combating illiteracy are but a few of the problems that need to be solved in order to improve the ąuality of life of village families

  15. ELEMENTOS SOBRE LA HISTORIA DEL CONCEPTO DE DESARROLLO SEGÚN LOS ECONOMISTAS THEOTONIO DOS SANTOS Y GILBERT RIST

    OpenAIRE

    Francisco Javier Criollo; Ana María Córdoba Barahona; Wilson Josué Segura; Ángela Castillo; Santiago Felipe Calderón; Miguel Ángel Figueroa

    2009-01-01

    El artículo tiene como propósito presentar la percepción y las inquietudes que dos importantes pensadores económicos ofrecen a través de sus obras sobre dependencia económica y desarrollo, como punto de partida en la reflexión que se ha iniciado sobre algunos conceptos que se convierten en clave para una discusión o debate. El estudio de una de las obras de Theotonio Dos Santos y otra de Gilbert Rist sobre la temática mencionada, le deja al grupo de investigación importantes inquietudes para ...

  16. Anesthetic management of a case of Gilbert's syndrome for mitral and aortic valve replacement: Role of transesophageal echocardiography

    Directory of Open Access Journals (Sweden)

    P S Nagaraja

    2017-01-01

    Full Text Available Gilbert's syndrome (GS is an autosomal inherited disorder characterized by relative deficiency of glucuronyl transferase and poor uptake of unconjugated bilirubin by hepatocytes. Cardiac surgery on cardiopulmonary bypass (CPB in these patients triggers further hepatic dysfunction. Transesophageal echocardiography (TEE and Doppler assessment of hepatic vein help in assessing hepatic blood flow (HBF during cardiac surgery. Here, we discuss anesthetic management and role of TEE in maintaining HBF perioperatively in a 25-year-old male patient with GS undergoing double valve replacement with tricuspid valve plasty. TEE-guided HBF monitoring and management of hepatic perfusion by modifying anesthetic and CPB protocol resulted in the favorable outcome.

  17. Prevalence of Gilbert syndrome in parents of neonates with pathologic indirect hyperbilirubinemia.

    Science.gov (United States)

    Saki, Forough; Hemmati, Fariba; Haghighat, Mahmoud

    2011-01-01

    The cause of hyperbilirubinemia cannot be found in about 45% of cases of neonatal jaundice. Gilbert syndrome (GS) is the most common congenital disease associated with bilirubin metabolism in the liver. Since the screening value of genetic tests cannot be fully determined until accurate data on the prevalence and penetrance of the GS genotype are known, we sought to estimate whether the prevalence of GS is higher in the parents of neonates with severe unexplained indirect hyperbilirubinemia. Case-control study of parents of neonates with severe unexplained indirect hyperbilirubinemia admitted to a neonatal ward. We used the rifampin test (checked bilirubin before and 4 hours after administration of 600 mg rifampin) for diagnosis of GS in parents of 115 neonates with severe unexplained indirect hyperbilirubinemia. We compared the prevalence of GS in these parents with that of a control group of 115 couples referred for premarital counseling. The 115 neonates were aged 5.2 (1.6) days (mean, standard deviation), all were breast-fed, and males constituted 56.5%. Mean total serum bilirubin (TSB) level was 20.96 (5.48) mg/dL. 14.8% were glucose 6 phosphate dehydrogenase (G6PD) deficiency was present in 14.8%, and 10.4% had A, B or O blood group (ABO) incompatibilities with their mothers. There was no difference in the prevalence of GS between parents of the group with hyperbilirubinemia (22.2%) and the control group (19.13%) (P=.42). Mean TSB in neonates with parents who had GS was more (about 3 mg/dL) than in neonates with normal parents (P=.004). Fathers had GS twice as often as the mothers among the parents of neonates with hyperbilirubinemia (P=.003), among the control group (P=.009) and among neonates (P=.014). This study showed that GS cannot cause severe indirect hyperbilirubinemia by itself, but it may have a summative effect on rising bilirubin when combined with other factors, for example, G6PD. Our results showed that in GS, males are affected about twice as

  18. Gilbert syndrome redefined: a complex genetic haplotype influences the regulation of glucuronidation.

    Science.gov (United States)

    Ehmer, Ursula; Kalthoff, Sandra; Fakundiny, Bastian; Pabst, Brigitte; Freiberg, Nicole; Naumann, Ronald; Manns, Michael P; Strassburg, Christian P

    2012-06-01

    Gilbert syndrome (GS) is characterized by intermittent unconjugated hyperbilirubinemia without structural liver damage, affecting about 10% of the white population. In GS the UGT1A1*28 variant reduces bilirubin conjugation by 70% and is associated with irinotecan and protease inhibitor side effects. The aim of this study was to characterize potential in vivo consequences of UGT1A gene variability in GS. Three hundred GS patients (UGT1A1*28 homozygous) and 249 healthy blood donors (HBD) were genotyped for UGT1A (UGT1A1*28, UGT1A3-66 T>C, UGT1A6*3a, UGT1A7*3) and transporter single nucleotide polymorphisms (SNPs) (SCLO1B1 p.V174A, SCLO1B1 p.N130D, ABCC2 p.I1324I, ABCC2-24 UTR) using TaqMan-5'-nuclease-assays. A humanized transgenic UGT1A-SNP and corresponding wildtype mouse model were established carrying the GS-associated UGT1A variant haplotype. UGT1A transcript and protein expression, and transcriptional activation were studied in vivo. Homozygous UGT1A1*28 GS individuals were simultaneously homozygous for UGT1A3-66 T>C (91%), UGT1A6*2a (77%), and UGT1A7*3 (77%). Seventy-six percent of GS and only 9% of HBD were homozygous for the variant haplotype spanning four UGT1A genes. SCLO1B1 and ABCC2 SNPs showed no differences. In transgenic humanized UGT1A SNP and wildtype mice this UGT1A haplotype led to lower UGT1A messenger RNA (mRNA) expression and UGT1A protein synthesis. UGT1A transcriptional activation by dioxin, phenobarbital, and endotoxin was significantly reduced in SNP mice. Our data redefine the genetic basis behind GS. In vivo data studying the genotype present in 76% of GS individuals suggest that transcription and transcriptional activation of glucuronidation genes responsible for conjugation and detoxification is directly affected, leading to lower responsiveness. This study suggests that GS should be considered a potential risk factor for drug toxicity. Copyright © 2011 American Association for the Study of Liver Diseases.

  19. Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey.

    Science.gov (United States)

    Lian, Wei; Liu, Hui; Song, QuanQuan; Liu, Yun Qi; Sun, Li Yan; Deng, Qing; Wang, Shao Ping; Cao, Yan Hong; Zhang, Xue Ying; Jiang, Yuan Yuan; Lv, Hong Yan; Duan, Li Bin; Yu, Jun

    2018-01-01

    Osteoarthritis (OA) is a considerable health problem worldwide, and the prevalence of OA varies in different regions. In this study, the prevalence of OA in Kashin-Beck disease (KBD) and non-KBD endemic areas was examined, respectively. According to monitoring data, 4 types of regions (including none, mild, moderate and high KBD endemic areas) in Heilongjiang and Jilin provinces were selected. All local residents were eligible for inclusion criteria have undergone X-ray images of hands and anteroposterior image of knees. A total of 1673 cases were collected, 1446 cases were analyzed after removing the KBD patients (227). The overall hand OA and knee OA detection rates were 33.3% (481/1446) and 56.6% (818/1446), respectively. After being standardized by age, the detection rate of hand OA in the KBD endemic areas was significantly higher than that in the non-endemic endemic areas. Differently, there was no significant difference in the detection rates of knee OA between the KBD endemic areas and the non-endemic area. The correlation coefficient between the severity of OA and the severity of knee OA was 0.358 and 0.197 in the KBD and non-KBD endemic areas, respectively. Where the KBD historical prevalence level was higher, the severity of the residents' hand OA was more serious. The detection rates of hand OA and knee OA increased with age. The detection rate of knee OA increased with the increase in body mass index. The prevalence of hand OA was closely related to the pathogenic factors of Kashin-Beck disease, and the prevalence of knee OA had no significant correlation with KBD pathogenic factors.

  20. Diasporic Reconciliations of Politics, Love and Trauma: Susan Abulhawa’s Quest for Identity in Mornings in Jenin

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    Ayman M Abu-Shomar

    2015-04-01

    Full Text Available Negotiating human conditions is an emblematic critical impetus of diaspora informed by multiple cultural possibilities practiced through the creation of multiple spaces that cross the realm of the ‘self’ to that of the ‘other’. It offers a locale to cross from the oppressed ‘self’ to an understanding of an oppressor ‘other’. Yet, diasporic negotiation is politically involved in the most responsible manner; it engages the contextual social realities in order to enable creative possibilities for overcoming the logic of the politics altogether. It invites a kind of political involvement that assures the ‘situatedness of the ethical’ in a framework of moral humanistic realisations. The realisation of diasporic negotiations is dialogically engaged in manners that will give birth to new possibilities for human togetherness. In this essay, I trace the signs of diasporic negotiations of politics, love and trauma in Susan Abulhawa’s Mornings in Jenin by focusing on the Diasporic identity of Amal (the central character. I consider the intersections between diaspora, dislocation of identity and the creation of negotiating spaces that qualify an 'epistemology of Diaspora' against essentialised and ethnocentric construction of realities. I argue that Abulhawa creates diasporic spaces and immense moral scenes to transcend a particular stance of politics via transcending love in opposition to suffering and tribulation. I contend that Abulhawa’s conceptualisation of Diasporic negotiations enables her to depict and gauge two extreme human sentiments: love and trauma, yet, without yielding or compromising the right of just resistance and dissent. Keywords: Diaspora, humanism, Trauma, identity, negotiating difference, and 'Otherness'

  1. Spin dynamics and relaxation in the classical-spin Kondo-impurity model beyond the Landau-Lifschitz-Gilbert equation

    Science.gov (United States)

    Sayad, Mohammad; Potthoff, Michael

    2015-11-01

    The real-time dynamics of a classical spin in an external magnetic field and local exchange coupled to an extended one-dimensional system of non-interacting conduction electrons is studied numerically. Retardation effects in the coupled electron-spin dynamics are shown to be the source for the relaxation of the spin in the magnetic field. Total energy and spin is conserved in the non-adiabatic process. Approaching the new local ground state is therefore accompanied by the emission of dispersive wave packets of excitations carrying energy and spin and propagating through the lattice with Fermi velocity. While the spin dynamics in the regime of strong exchange coupling J is rather complex and governed by an emergent new time scale, the motion of the spin for weak J is regular and qualitatively well described by the Landau-Lifschitz-Gilbert (LLG) equation. Quantitatively, however, the full quantum-classical hybrid dynamics differs from the LLG approach. This is understood as a breakdown of weak-coupling perturbation theory in J in the course of time. Furthermore, it is shown that the concept of the Gilbert damping parameter is ill-defined for the case of a one-dimensional system.

  2. Mercury concentration in the freshwater bonefish Cyphocharax gilbert (Curimatidae and its parasite the crustacean Riggia paranensis (Cymothoidae

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    Débora C. Lins

    Full Text Available Fish parasites can accumulate heavy metals reaching higher concentrations than the host and may affect the host's bioaccumulation. The present study compared total mercury concentration in the liver and muscle of Cyphocharax gilbert and in the parasite Riggia paranensis sampled in the middle Itabapoana River, Brazil, also considering the reproductive stages of both fish and parasite. Mean concentrations of mercury in muscle of fish varied from 20.8 ng.g-1 in mature females to 38.1 ng.g-1 in post-spawning females. The mean concentrations in fish liver varied from 60.9 ng/g in post-spawning females to 110.4 ng.g-1 in infested males. The mean concentration of mercury in parasites varied from 26.2 ng.g-1 in specimens carrying early embryo to 39.5 ng.g-1 in specimens with eggs. Positive and significant associations (P<0.05 were found between the total mercury concentrations in parasites and muscle of host (both females and males, and between concentrations in parasites and in the liver of male hosts. These results suggest that R. paranensis can be used to indicate mercury levels in edible parts of C. gilbert.

  3. Parasitic castration, growth, and sex steroids in the freshwater bonefish Cyphocharax gilbert (Curimatidae infested by Riggia paranensis (Cymothoidea

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    Neuza R. W. Lima

    Full Text Available Cyphocharax gilbert shows parasitic castration when infested by the crustacean Riggia paranensis, being unable to reproduce. Fish were sampled in the middle rio Itabapoana, Brazil, to study the prevalence of parasitism, growth, and sex steroid concentrations, considering the body size, sex, and reproductive condition of specimens. Most of the fish analyzed were infested (56.0%. The presence of two lines on the scales was more frequent among infested fish (22.0% than among fish without parasites (12.0% for females and 10.0% for males. The occurrence of three lines on the scales was rare (3.5% among infested and 2.0% among females without parasites. These results suggest that growth of the host is faster than that of non infested fish. The serum concentrations of sex steroids from fish without parasites varied at different gonadal development stages (17 beta-estradiol: 60.0 to 976.7 pg/ml; total testosterone: 220.0 to 3,887.7 pg/ml. All infested fish had lower levels of the two sex steroids and undeveloped gonads. Sex steroids levels in infested females were close to those in females at post-spawning stages. Total testosterone concentrations of infested males were below those of males at early gonadal maturation stage. These results suggest that R. paranensis reduces the reproductive capacity of C. gilbert by affecting the host endocrine system.

  4. Preface to anthropogenic fluvial sedimentation: Centennial celebration of G.K. Gilbert's Hydraulic-Mining Débris in the Sierra Nevada

    Science.gov (United States)

    James, L. Allan; Phillips, Jonathan D.; Lecce, Scott A.

    2017-10-01

    This special issue celebrates the centennial of the publication of G.K. Gilbert's (1917) monograph, Hydraulic-Mining Débris in the Sierra Nevada, U.S. Geological Survey Professional Paper 105 (PP105). Reasons to celebrate PP105 are manifold. It was the last of four classic monographs that Gilbert wrote in a career that spanned five decades. The monograph, PP105, introduced several important concepts and provided an integrated view of watersheds that was uncommon in its day. It also provided an extreme, lucid example of anthropogenic changes and legacy sediment and how to approach such large-scale phenomena from an objective, quantitative basis.

  5. Impact on electroencephalography of Adolf Beck, a prominent Polish scientist and founder of the Lviv School of Physiology.

    Science.gov (United States)

    Zayachkivska, Oksana; Gzhegotsky, Mechyslav; Coenen, Anton

    2012-07-01

    Adolf Beck (1863-1942) can be regarded as the co-founder of electroencephalography. His studies on the cerebral cortex of animals have facilitated the introduction of the electroencephalogram (EEG) as a main tool for studying the brain. The localization of senses on the cortex with evoked potentials and the description of the desynchronization of the electrical brain activity upon stimulation, are hallmarks of the research of Beck. He performed his groundbreaking studies under supervision of the famous Napoleon Cybulski at the Jagiellonian University in Cracow (Poland) between 1888 and 1895. In that last year Beck was appointed professor at the University of Lemberg (Lviv), where he founded the Department of Physiology and recruited scientists to the Lviv School of Physiology. Beck was the leading authority of the University of Lemberg in the most turbulent period of the town's history. Together with Cybulski he wrote the influential textbook 'Human physiology' in 1915. Copyright © 2011 Elsevier B.V. All rights reserved.

  6. Vozvrashtshenije "Ekzorsista" / Susan Howard

    Index Scriptorium Estoniae

    Howard, Susan

    2001-01-01

    William Friedkini 1973.a. valminud õudusfilm "Exorcist", selle järjed ja selle hiljuti restaureeritud ja taas ekraanile paisatud versioon ning nende mõju näitlejanna Linda Blair'i elukäigule, kes filmis mängis saatanast vaevatud teistmelist

  7. Aaron Temkin BECK: After Cricitical Thinking to A Creative Psychotherapy Theory

    Directory of Open Access Journals (Sweden)

    Mehmet DÝNÇ

    2012-08-01

    Full Text Available There is growing interest in the cognitive psychotherapy all around the world including Turkey. According to American Institute of cognitive Therapy; cognitive psychotherapy is the fastest growing and most rigorously studied kind of talk therapy and it is practiced around the world, taking hold in places from the Middle East to Japan. Cognitive psychotherapy was designed first by Aaron Temkin Beck in 1950’s. He has published over 450 articles and authored or co-authored seventeen books and he has been listed as one of the “10 individuals who shaped the face of American Psychiatry” and one of the 5 most influential psychotherapists of all time since then. Beck’s groundbreaking systematic research established for the first time the efficacy of any psychotherapy for the treatment of depression. Moreover he not only developed and tested an effective short-term treatment (cognitive therapy for depression, but he and his former students have successfully adapted cognitive therapy to a wide range of other psychiatric disorders as well. Numerous controlled clinical trials have now demonstrated that cognitive therapy is effective in a variety of psychiatric conditions including depression, bulimia nervosa, hypochondriasis, social phobia, obsessive-compulsive disorder, substance abuse, body dysmorphic disorder, and post-traumatic stress disorder. Therefore knowing the father of cognitive therapy and his journey from 1950’s to 2010’s will help to understand cognitive therapy and its development during these years. This article aims to give an overview of the historical background to contemporary cognitive and cognitive-behavioral approaches to psychotherapy by focusing on Beck’s life, characteristics and works. [JCBPR 2012; 1(2.000: 70-76

  8. Validation of the Beck Hopelessness Scale in patients with suicide risk.

    Science.gov (United States)

    Rueda-Jaimes, German Eduardo; Castro-Rueda, Vanessa Alexandra; Rangel-Martínez-Villalba, Andrés Mauricio; Moreno-Quijano, Catalina; Martinez-Salazar, Gustavo Adolfo; Camacho, Paul Anthony

    2016-11-30

    Only a few scales have been validated in Spanish for the assessment of suicide risk, and none of them have achieved predictive validity. To determine the validity and reliability of the Beck Hopelessness Scale in patients with suicide risk attending the specialist clinic. The Beck Hopelessness Scale, reasons for living inventory, and the suicide behaviour questionnaire were applied in patients with suicide risk attending the psychiatric clinic and the emergency department. A new assessment was made 30 days later to determine the predictive validity of suicide or suicide attempt. The evaluation included a total of 244 patients, with a mean age of 30.7±13.2 years, and the majority were women. The internal consistency was .9 (Kuder-Richardson formula 20). Four dimensions were found which accounted for 50% of the variance. It was positively correlated with the suicidal behaviour questionnaire (Spearman .48, P<.001), number of suicide attempts (Spearman .25, P<.001), severity of suicide risk (Spearman .23, P<.001). The correlation with the reasons for living inventory was negative (Spearman -.52, P<.001). With a cut-off ≥12, the negative predictive value was 98.4% (95% CI: 94.2-99.8), and the positive predictive value was 14.8% (95% CI: 6.6-27.1). The Beck Hopelessness Scale in Colombian patients with suicidality shows results similar to the original version, with adequate reliability and moderate concurrent and predictive validity. Copyright © 2016 SEP y SEPB. Publicado por Elsevier España, S.L.U. All rights reserved.

  9. Weber, Beck y creación feminista de sentido en la escuela

    OpenAIRE

    Burgués, A. (Ana); Serradell Pumareda, Olga

    2009-01-01

    En las sociedades actuales se ha producido de manera generalizada una pérdida de sentido de las instituciones. Por un lado, a través de algunas de las aportaciones de autores de la teoría sociológica clásica como Weber y contemporánea como Beck, analizamos la pérdida de sentido que se da en las sociedades contemporáneas hacia la institución educativa. Por otro lado, analizamos algunas de las acciones que los sujetos llevan a cabo y que aportan de nuevo sentido a la escuela. Para ello partimos...

  10. Cytoskeleton remodeling and oxidative stress description in morphologic changes of chondrocyte in Kashin-Beck disease.

    Science.gov (United States)

    Ma, Wei Juan; Guo, Xiong; Yu, Yue Xiang; Gao, Zong Qiang

    2014-12-01

    Kashin-Beck disease (KBD) is a kind of deformity disease involved in cytoskeleton and inner homeostasis regulation. The enrichment analysis of bioprocess, networks, and related disease set were performed. The development regulation, metabolic process, and apoptosis were important procession in KBD; it revealed the up-regulated process in removal of superoxide radicals, glycolysis and glucose catabolic process, regulation of cytoskeleton rearrangement and phagosome in antigen presentation. Morphological changes of KBD chondrocyte were investigated by transmission electronic microscopy compare with the normal one. The ultrastructure of KBD chondrocyte referred to oxidative stress and metabolic dysfunction has been found.

  11. Depressive symptoms in breast cancer: Beck Depression Inventory – Short Form.

    OpenAIRE

    Cangussu, Renata de Oliveira; Soares, Thiago Barbabela de Castro; Barra, Alexandre de Almeida; Nicolato, Rodrigo

    2010-01-01

    Objetivos: Verificar a prevalência de sintomas depressivos em mulheres com câncer de mama e identificar os fatores de risco associados à sua ocorrência. Métodos: Foi realizado um estudo transversal, em que foram entrevistadas 71 mulheres com câncer de mama. Foram empregados dois instrumentos: um questionário para verificar os dados sociodemográficos e clínicos e o Inventário de Depressão de Beck – Short Form (BDI-SF), para avaliação dos sintomas depressivos. Para análise dos da...

  12. Beck Hopelessness Scale: Psychometric Properties Among Rural Chinese Suicide Attempters and Non-Attempters.

    Science.gov (United States)

    Zhang, Wen-Chao; Jia, Cun-Xian; Hu, Xia; Qiu, Hui-Min; Liu, Xian-Chen

    2015-01-01

    The authors recruited 401 suicide attempters from general hospitals and 409 matched non-attempters to evaluate the psychometric properties of the Beck Hopelessness Scale (BHS) in rural China. All participants completed the BHS, Center for Epidemiologic Studies Depression Scale (CES-D), and Trait Anxiety Inventory (TAI). Suicide attempters had higher BHS scores than non-attempters. Cronbach's alpha coefficients were satisfactory and BHS scores significantly correlated to CES-D and TAI scores. Confirmatory factor analysis supported a four-factor model for suicide attempters and a five-factor model for non-attempters. The BHS is satisfactory in assessing hopelessness among suicide attempters in rural China.

  13. Reut and Beck columns: effects of end gravity force, translational and rotational inertias

    OpenAIRE

    Luis G. Arboleda Monsalve; David G. Zapata Medina; J. Darío Aristizabal Ochoa

    2012-01-01

    Se presenta la estabilidad de las colunmas de Reut y Beck sometidas a cualquier combinación de fuerzas compresivas axiales de gravedad y no conservativas (fuerza fija a lo largo de una línea o seguidora) utilizando la formulación dinámica. El método propuesto es general y captura el pandeo estático (o divergencia) y la inestabilidad dinámica ("flameo") de columnas en voladizo. Los efectos de la fuerza de gravedad y las inercias traslacionales y rotacionales a lo largo del elemento se analizan...

  14. Dennis C. Roberts & Susan R. Komives (Eds. (2016. Enhancing Student Learning and Development in Cross-Border Higher Education. San Francisco: Jossey-Bass.

    Directory of Open Access Journals (Sweden)

    Munita Dunn-Coetzee

    2017-07-01

    Full Text Available Enhancing Student Learning and Development in Cross-Border Higher Education, edited by Dennis C. Roberts and Susan R. Komives, is a book that resulted from a short-term study-abroad experience between the Universities of Maryland and San Diego with the Qatar Foundation’s Education City in Doha in 2010. This partnership challenged the way in which higher education internalisation was viewed – in such a way that the visit was replicated in 2012 and this book was authored.

  15. Cross-cultural examination of measurement invariance of the Beck Depression Inventory-II.

    Science.gov (United States)

    Dere, Jessica; Watters, Carolyn A; Yu, Stephanie Chee-Min; Bagby, R Michael; Ryder, Andrew G; Harkness, Kate L

    2015-03-01

    Given substantial rates of major depressive disorder among college and university students, as well as the growing cultural diversity on many campuses, establishing the cross-cultural validity of relevant assessment tools is important. In the current investigation, we examined the Beck Depression Inventory-Second Edition (BDI-II; Beck, Steer, & Brown, 1996) among Chinese-heritage (n = 933) and European-heritage (n = 933) undergraduates in North America. The investigation integrated 3 distinct lines of inquiry: (a) the literature on cultural variation in depressive symptom reporting between people of Chinese and Western heritage; (b) recent developments regarding the factor structure of the BDI-II; and (c) the application of advanced statistical techniques to the issue of cross-cultural measurement invariance. A bifactor model was found to represent the optimal factor structure of the BDI-II. Multigroup confirmatory factor analysis showed that the BDI-II had strong measurement invariance across both culture and gender. In group comparisons with latent and observed variables, Chinese-heritage students scored higher than European-heritage students on cognitive symptoms of depression. This finding deviates from the commonly held view that those of Chinese heritage somatize depression. These findings hold implications for the study and use of the BDI-II, highlight the value of advanced statistical techniques such as multigroup confirmatory factor analysis, and offer methodological lessons for cross-cultural psychopathology research more broadly. 2015 APA, all rights reserved

  16. ELEMENTOS SOBRE LA HISTORIA DEL CONCEPTO DE DESARROLLO SEGÚN LOS ECONOMISTAS THEOTONIO DOS SANTOS Y GILBERT RIST

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    Francisco Javier Criollo

    2009-01-01

    Full Text Available El artículo tiene como propósito presentar la percepción y las inquietudes que dos importantes pensadores económicos ofrecen a través de sus obras sobre dependencia económica y desarrollo, como punto de partida en la reflexión que se ha iniciado sobre algunos conceptos que se convierten en clave para una discusión o debate. El estudio de una de las obras de Theotonio Dos Santos y otra de Gilbert Rist sobre la temática mencionada, le deja al grupo de investigación importantes inquietudes para la construcción de un pensamiento propio y alternativo.

  17. The extrapolated explicit midpoint scheme for variable order and step size controlled integration of the Landau-Lifschitz-Gilbert equation

    Science.gov (United States)

    Exl, Lukas; Mauser, Norbert J.; Schrefl, Thomas; Suess, Dieter

    2017-10-01

    A practical and efficient scheme for the higher order integration of the Landau-Lifschitz-Gilbert (LLG) equation is presented. The method is based on extrapolation of the two-step explicit midpoint rule and incorporates adaptive time step and order selection. We make use of a piecewise time-linear stray field approximation to reduce the necessary work per time step. The approximation to the interpolated operator is embedded into the extrapolation process to keep in step with the hierarchic order structure of the scheme. We verify the approach by means of numerical experiments on a standardized NIST problem and compare with a higher order embedded Runge-Kutta formula. The efficiency of the presented approach increases when the stray field computation takes a larger portion of the costs for the effective field evaluation.

  18. Atenciografia do Corpo: interseções entre Lisa Nelson e Gilbert Simondon a partir de um fragmento de relato

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    Francisco de Assis Gaspar Neto

    2017-01-01

    Full Text Available O artigo propõe uma interseção entre arte e filosofia aproximando uma pratica de atenção em uma seção de Tuning Scores, descrita pela coreografa e video-maker americana Lisa Nelson, a relação do individuo com o meio e com outros indivíduos, pensada pelo filósofo francês Gilbert Simondon. O fragmento de descrição de Lisa Nelson acerca da atenciografia do corpo será lido em conjugação com os caracteres que Simondon apresenta na relação interpessoal: individuação, individualização e personalidade.

  19. A Biography of Distinguished Scientist Gilbert Newton Lewis (by Edward S. Lewis)

    Science.gov (United States)

    Harris, Reviewed By Harold H.

    1999-11-01

    The Edward Mellen Press: Lewiston, NY, 1998. 114 pp + index. ISBN 0-7734-8284-9. $69.95. There may not be a surname better known to students of chemistry than Lewis, from the Lewis electron-dot diagrams and the Lewis theory of acids and bases. More advanced students may know of the groundbreaking textbook Thermodynamics, by Lewis and Randall. Yet few Americans know much about this remarkable U.S.-born scholar, whose contributions equal those of the greatest scientists. He is a chemist-educator of whom we should be as proud and as well informed as we are of Linus Pauling, who was part of the westward movement of science in this country that G. N. Lewis began, or of the recently deceased Glenn Seaborg, who was one of the many students of Lewis who achieved renown. Gilbert N. Lewis was born in Weymouth, Massachusetts, in 1875, but his family moved to near Lincoln, Nebraska, in 1884. He spent two years at the University of Nebraska, but then moved to Harvard when his father became an executive at Merchants Trust Company in Boston. Young Lewis (then only 17) was also said to have been disappointed with the quality of education in Nebraska, and this may have been part of the impetus for the family's move east. After earning his baccalaureate at Harvard, he taught for a year at Phillips Andover Academy before returning to Harvard to study for his doctorate, which he completed 100 years ago, in 1899, under T. W. Richards. Lewis's doctoral work was on the thermodynamics of zinc and cadmium amalgams. At that time, physical chemistry was only beginning to achieve recognition as a branch of science, and its boundaries were ill defined. Edward Lewis quotes his father as often saying, "Physical chemistry is anything interesting." Like many chemists of his time, Lewis went to Europe to complete his preparation for a career; he was in the laboratories of Ostwald in Leipzig and Nernst in Göttingen in 1900-1901. On his return to the United States, he was an instructor at Harvard

  20. Teoria da resposta ao item aplicada ao Inventário de Depressão Beck Item response theory applied to the Beck Depression Inventory

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    Stela Maris de Jezus Castro

    2010-09-01

    Full Text Available O Inventário de Depressão Beck (BDI, uma escala que mede o traço latente de intensidade de sintomas depressivos, pode ser avaliado através da Teoria da Resposta ao Item (TRI. Este estudo utilizou o modelo TRI de Resposta Gradual na avaliação da intensidade de sintomas depressivos de 4.025 indivíduos que responderam ao BDI, de modo a explorar eficientemente a informação disponível nos diferentes aspectos possibilitados pelo uso desta metodologia. O ajuste foi efetuado no software PARSCALE. Foram identificados 13 itens do BDI nos quais pelo menos uma categoria de resposta não tinha chance maior que as demais de ser escolhida, de modo que estes itens tiveram de ser recategorizados. Os itens com maior capacidade de discriminação são relativos à tristeza, pessimismo, sentimento de fracasso, insatisfação, auto-aversão, indecisão e dificuldade para trabalhar. Os itens mais graves são aqueles relacionados com perda de peso, retraimento social e idéias suicidas. O grupo dos 202 indivíduos com as maiores intensidades de sintomas depressivos foi composto por 74% de mulheres, e praticamente 84% possuíam diagnóstico de algum transtorno psiquiátrico. Os resultados evidenciam alguns dos inúmeros ganhos advindos da utilização da TRI na análise de traços latentes.The Beck Depression Inventory (BDI, a scale that measures the latent trait intensity of depression symptoms, can be assessed by the Item Response Theory (IRT. This study used the Graded-Response model (GRM to assess the intensity of depressive symptoms in 4,025 individuals who responded to the BDI, in order to efficiently use the information available on different aspects enabled by the use of this methodology. The fit of this model was done in PARSCALE software. We identified 13 items of the BDI in which at least one response category was not more likely than others to be chosen, so that these items had to be categorized again. The items with greater power of

  1. [Change on the rate of children's finger metaphysics in the non-Kaschin-Beck disease areas of China].

    Science.gov (United States)

    Gao, Mei; Liu, Yunqi; Zhou, Lingwang; Liu, Hui; Deng, Qing; Song, Jiucheng; Yu, Jun

    2014-11-01

    36 non-Kaschin-Beck disease villages in five provinces including Jilin, Liaoning, Shaanxi, Shanxi and Inner Mongolia in the severe endemic areas of Kaschin-Beck disease (KBD) were selected. The aim of this project was to provide the basis showing these KBD villages had already eliminated the KBD. Fully digital versatile X-ray radiography systems(DR) was used to shoot children's right hand X-ray, in accordance with the "Kashin-Beck Disease Diagnosis Standard" (WS/T 207-2010) for diagnosis. Results indicated that children showing metaphyseal changes only appeared in 13 of the 36 villages, where the rate of change on metaphyseal was less than or equal to three percent. When KBD had been eliminated in a village, the rate of change on aged 7 to 12 children's metaphyseal would have been less than three percent.

  2. The Beck Anxiety Inventory-Trait (BAIT): a measure of dispositional anxiety not contaminated by dispositional depression.

    Science.gov (United States)

    Kohn, Paul M; Kantor, Ludmila; DeCicco, Teresa L; Beck, Aaron T

    2008-09-01

    We describe development of the Beck Anxiety Inventory-Trait (BAIT), a measure of trait anxiety. In Study 1 with 191 undergraduates, the BAIT correlated higher with another trait-anxiety measure than with state anxiety and trait depressiveness and lower with depressiveness than the other trait-anxiety measure did. In Study 2 (Ns of 149 undergraduates initially and 107 at 3 weeks later), the BAIT demonstrated convergent validity against the Beck Anxiety Inventory (BAI; Beck, Epstein, Brown, & Steer, 1988) and self-rated trait anxiety plus discriminant validity against abstract curiosity. In Study 3 (Ns of 161 undergraduates initially and 121 at 3 weeks later), the BAIT correlated more highly with another anxiety measure than with depression, stress, positive affect, and negative affect. It also showed good internal consistency across studies and high stability in Studies 2 and 3, higher than the BAI's in Study 2. Factor analyses across studies all supported 2 factors, 1 Somatic and 1 Subjective.

  3. Requestioning depression in patients with cancer: contribution of somatic and affective symptoms to Beck's Depression Inventory.

    Science.gov (United States)

    Wedding, U; Koch, A; Röhrig, B; Pientka, L; Sauer, H; Höffken, K; Maurer, I

    2007-11-01

    Depressive symptoms are a major complaint reported by cancer patients. Somatic and affective symptoms can contribute to depression. We investigated the prevalence of somatic and affective depressive symptoms with the Beck Depression Inventory (BDI) in 213 hospitalized cancer patients prior to the start of chemotherapy. Seventeen of 213 patients (8%) were screened positive for major depression; 40 (19%) had mild to moderate depressive symptoms. The corresponding figures for somatic and affective symptoms were 33.3% and 2.8% in the patients with major depression and 23.0% and 8.0% in those with mild to moderate depressive symptoms. Female patients, patients with solid tumour and those with functional limitations had significantly higher mean scores. All differences were related to higher scores in somatic and not in affective items. Most alterations in the BDI in cancer patients are related to somatic and not to affective symptoms and may be attributed not to depression but to severity of the underlying disease.

  4. The role of psychological inflexibility in Beck's cognitive model of depression in a sample of undergraduates

    Directory of Open Access Journals (Sweden)

    Francisco J. Ruiz

    Full Text Available Beck's cognitive model of depression proposes that depressogenic schemas have an effect on depressive symptoms by increasing the frequency of negative automatic thoughts in response to negative life events. We aimed to test a moderated, serial mediation model where psychological inflexibility, a core concept of the Acceptance and Commitment Therapy (ACT model of psychopathology, both mediates and moderates the relationship between depressogenic schemas and the frequency of negative automatic thoughts. A cross-sectional design was used in which 210 undergraduates responded to questionnaires assessing the constructs of interest. Results supported the proposed moderated mediation model. Both psychological inflexibility and negative automatic thoughts were significant mediators of the relationship between depressogenic schemas and depressive symptoms, and psychological inflexibility also moderated the effect of depressogenic schemas on negative automatic thoughts. We conclude that the role of psychological inflexibility in the cognitive model of depression deserves more attention.

  5. A terapia cognitiva de Aaron Beck como reflexividade na alta modernidade: uma sociologia do conhecimento

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    Cláudio Ivan de Oliveira

    Full Text Available Uma sociologia do conhecimento interpreta a produção do conhecimento como vinculada a situações sociais. Partindo dessa premissa epistemológica, nosso artigo objetivou interpretar a terapia cognitiva de Aaron Beck como conhecimento construído e construtor do fenômeno de reflexividade da alta modernidade, conforme interpretada por Anthony Giddens. Nossa hipótese é que a reorientação do sistema de crenças do cliente, proposta pela terapia cognitiva, é uma forma de reconstrução reflexiva da autoidentidade, visando superar conflitos típicos da instabilidade da alta modernidade. Assinalamos aspectos na terapia cognitiva que a identificam com a reflexividade, sobretudo a ideia de que a construção da autoidentidade é uma tarefa na qual o indivíduo se engaja reflexivamente.

  6. Poor Sleep in Multiple Sclerosis Correlates with Beck Depression Inventory Values, but Not with Polysomnographic Data

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    Christian Veauthier

    2016-01-01

    Full Text Available Objectives. Pittsburgh Sleep Quality Index (PSQI values correlate with depression, but studies investigating the relationship between PSQI values and polysomnographic (PSG data showed inconsistent findings. Methods. Sixty-five consecutive patients with multiple sclerosis (MS were retrospectively classified as “good sleepers” (GS (PSQI ≤ 5 and “poor sleepers” (PS (PSQI > 5. The PSG data and the values of the Visual Analog Scale (VAS of fatigue, Modified Fatigue Impact Scale (MFIS, Fatigue Severity Scale (FSS, Epworth Sleepiness Scale (ESS, and the Beck Depression Inventory (BDI were compared. Results. No significant differences were found either for PSG data or for ESS, MFIS, and FSS values; but PS showed significantly increased BDI and VAS values. Conclusions. Poor sleep is associated with increased depression and fatigue scale values.

  7. Examination of the Beck Depression Inventory-II Factor Structure Among Bariatric Surgery Candidates.

    Science.gov (United States)

    Hayes, Sharon; Stoeckel, Nina; Napolitano, Melissa A; Collins, Charlotte; Wood, G Craig; Seiler, Jamie; Grunwald, Heidi E; Foster, Gary D; Still, Christopher D

    2015-07-01

    The Beck Depression Inventory-II (BDI-II) is frequently used to evaluate bariatric patients in clinical and research settings; yet, there are limited data regarding the factor structure of the BDI-II with a bariatric surgery population. Exploratory factor analysis (EFA) using principal axis factoring with oblimin rotation was employed with data from 1228 consecutive presurgical bariatric candidates. Independent t tests were used to examine potential differences between sexes. Confirmatory factor analysis (CFA) was conducted with the next 383 consecutive presurgical patients to evaluate the proposed model based on EFA results. EFA revealed three factors: negative perceptions, diminished vigor, and cognitive dysregulation, each with adequate internal consistency. Six BDI-II items did not load significantly on any of the three factors. CFA results largely supported the proposed model. Results suggest that dimensions of depression for presurgical bariatric candidates vary from other populations and raise important caveats regarding the utility of the BDI-II in bariatric research.

  8. Arthroscopic Ankle Arthrodesis for Treating Osteoarthritis in a Patient with Kashin-Beck Disease

    Directory of Open Access Journals (Sweden)

    Kenjiro Iwasa

    2014-01-01

    Full Text Available Kashin-Beck disease (KBD is an endemic degenerative osteoarthritis. Death of cartilage and growth plate is the pathologic feature; therefore, KBD involves skeletal deformity and often results in osteoarthritis. Deficiency of selenium, high humic acid levels in water, and fungi on storage gains are considered the cause of KBD. The most frequently involved joints are ankles, knees, wrists, and elbows and symptoms are pain and limited motions of those joints. The main treatments for KBD are rehabilitation and osteotomy to correct the deformities because preventive treatment has not been established. In this report, we present a case of ankle osteoarthritis due to KBD and first describe arthroscopic ankle arthrodesis for treating osteoarthritis of KBD.

  9. Validation of the Polish version of the Beck Depression Inventory in patients with epilepsy.

    Science.gov (United States)

    Wiglusz, Mariusz S; Landowski, Jerzy; Michalak, Lidia; Cubała, Wiesław J

    2017-10-27

    Despite the fact that depressive disorders are the most common comorbidities among patients with epilepsy (PWE), such disorders often go unrecognized and untreated. In addition, the availability of validated screening instruments to detect depression in PWE is limited. The aim of the present study was thus to validate the Polish version of the Beck Depression Inventory (BDI) in adult PWE. A group of 118 outpatient PWE were invited to participate in the study. Ninety-six patients meeting the inclusion criteria completed the Polish Version of Beck Depression Inventory-I (BDI-I) and were examined by a trained psychiatrist using the Structured Clinical Interview (SICD-I) for Diagnostic and statistical manual of mental disorders - fourth edition (Text revision) (DSM-IV-TR). Receiver operating characteristic (ROC) curves were used to determine the optimal threshold scores for BDI. Receiver operating characteristic analysis showed the area under the curve to be approximately 84%. For major depressive disorder (MDD) diagnosis, the BDI demonstrated the best psychometric properties for a cut-off score to be 18, with a sensitivity of 90.5%, specificity of 70.7%, positive predictive value (PPV) of 46.3%, and negative predictive value (NPV) of 96.4%. For the 'any depressive disorder' group, the BDI optimum cut-off score was 11, with a sensitivity of 82.5%, specificity of 73.2%, PPV of 68.8%, and NPV of 85.4%. The BDI score is a valid psychometric indicator for depressive disorders in PWE maintaining adequate sensitivity and specificity, high NPV, and acceptable PPV with an optimum cut-off score of 18 for MDD diagnosis. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Psychometric properties of the Beck Depression Inventory-II in low-income, African American suicide attempters.

    Science.gov (United States)

    Joe, Sean; Woolley, Michael E; Brown, Gregory K; Ghahramanlou-Holloway, Marjan; Beck, Aaron T

    2008-09-01

    Cross-cultural examinations of the validity and reliability of the Beck Depression Inventory-II (Beck, Steer, Ball, & Ranieri, 1996) is essential for its use in assessment and monitoring of the effectiveness of suicide interventions across racial groups. We tested the fit of a second-order, two-factor model and the internal reliability of the BDI-II in a sample of 133 African Americans with a recent history of suicide attempts. Additionally, we examined the convergent validity with the Hamilton Rating Scale for Depression (Reynolds & Koback, 1995). The results indicate that the BDI-II is a reliable and valid measure of depressive symptoms for African American suicide attempters.

  11. ''Iatrogenic Gilbert syndrome''--a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin.

    Science.gov (United States)

    McCarty, Mark F

    2007-01-01

    The catabolism of heme, generating biliverdin, carbon monoxide, and free iron, is mediated by heme oxygenase (HO). One form of this of this enzyme, heme oxygenase-1, is inducible by numerous agents which promote oxidative stress, and is now known to provide important antioxidant protection, as demonstrated in many rodent models of free radical-mediated pathogenesis, and suggested by epidemiology observing favorable health outcomes in individuals carrying high-expression alleles of the HO-1 gene. The antioxidant impact of HO-1 appears to be mediated by bilirubin, generated rapidly from biliverdin by ubiquitously expressed biliverdin reductase. Bilirubin efficiently scavenges a wide range of physiological oxidants by electron donation. In the process, it is often reconverted to biliverdin, but biliverdin reductase quickly regenerates bilirubin, thereby greatly boosting its antioxidant potential. There is also suggestive evidence that bilirubin inhibits the activity or activation of NADPH oxidase. Increased serum bilirubin is associated with reduced risk for atherogenic disease in epidemiological studies, and more limited data show an inverse correlation between serum bilirubin and cancer risk. Gilbert syndrome, a genetic variant characterized by moderate hyperbilirubinemia attributable to reduced hepatic expression of the UDP-glucuronosyltransferase which conjugates bilirubin, has been associated with a greatly reduced risk for ischemic heart disease and hypertension in a recent study. Feasible strategies for boosting serum bilirubin levels may include administration of HO-1 inducers, supplementation with bilirubin or biliverdin, and administration of drugs which decrease the efficiency of hepatic bilirubin conjugation. The well-tolerated uricosuric drug probenecid achieves non-competitive inhibition of hepatic glucuronidation reactions by inhibiting the transport of UDP-glucuronic acid into endoplasmic reticulum; probenecid therapy is included in the differential

  12. Normative Values for the Beck Anxiety Inventory, Fear Questionnaire, Penn State Worry Questionnaire, and Social Phobia and Anxiety Inventory.

    Science.gov (United States)

    Gillis, Martha M.; And Others

    1995-01-01

    Adult community norms were derived from 261 adults who completed the Social Phobia and Anxiety Inventory and 267 adults who completed the Beck Anxiety Inventory, the Fear Questionnaire, and the Penn State Worry Questionnaire. Percentile scores are provided for all measures, and their usefulness in assessing therapy outcomes is discussed. (SLD)

  13. Using the Beck Anxiety Inventory among South Africans Living with HIV: Exploratory and Higher Order Factor Analyses

    Science.gov (United States)

    Kagee, Ashraf; Coetzee, Bronwyne; Saal, Wylene; Nel, Adriaan

    2015-01-01

    We administered the Beck Anxiety Inventory (BAI) to 101 adults receiving HIV treatment. Exploratory factor analysis yielded a single anxiety factor that accounted for 68.7% of the variance in the data. A single score may be used to indicate the overall level of anxiety of individuals receiving HIV treatment in South Africa.

  14. Beck's cognitive theory and the response style theory of depression in adolescents with and without mild to borderline intellectual disability

    NARCIS (Netherlands)

    Weeland, M.M.; Nijhof, K.S.; Otten, R.; Vermaes, I.P.R.; Buitelaar, J.K.

    2017-01-01

    Aim: This study tests the validity of Beck’s cognitive theory and Nolen-Hoeksema's response style theory of depression in adolescents with and without MBID. Methods: The relationship between negative cognitive errors (Beck), response styles (Nolen-Hoeksema) and depressive symptoms was examined in

  15. Impact on electroencephalography of Adolf Beck, a prominent Polish scientist and founder of the Lviv School of Physiology

    NARCIS (Netherlands)

    Zayachkivska, O.; Gzhegotsky, M.; Coenen, A.M.L.

    2012-01-01

    Adolf Beck (1863–1942) can be regarded as the co-founder of electroencephalography. His studies on the cerebral cortex of animals have facilitated the introduction of the electroencephalogram (EEG) as a main tool for studying the brain. The localization of senses on the cortex with evoked potentials

  16. Cross-Cultural Validation of the Beck Depression Inventory-II across U.S. and Turkish Samples

    Science.gov (United States)

    Canel-Cinarbas, Deniz; Cui, Ying; Lauridsen, Erica

    2011-01-01

    The purpose of this study was to test the Beck Depression Inventory-II (BDI-II) for factorial invariance across Turkish and U.S. college student samples. The results indicated that (a) a two-factor model has an adequate fit for both samples, thus providing evidence of configural invariance, and (b) there is a metric invariance but "no"…

  17. Beck Depression Inventory is a useful screening tool for major depressive disorder in Gilles de la Tourette syndrome.

    NARCIS (Netherlands)

    Snijders, A.H.; Robertson, M.M.; Orth, M.

    2006-01-01

    This study determined the prevalence of and factors associated with comorbid major depressive disorder (MDD) in patients with Gilles de la Tourette syndrome (GTS). How a simple self-report instrument, the Beck Depression Inventory (BDI), correlates with clinical assessment of comorbid MDD in this

  18. Psychometric Properties of the Chinese Version of the Beck Depression Inventory-II Using the Rasch Model

    Science.gov (United States)

    Wu, Pei-Chen; Chang, Lily

    2008-01-01

    The authors investigated the Chinese version of the Beck Depression Inventory-II (BDI-II-C; Chinese Behavioral Science Corporation, 2000) within the Rasch framework in terms of dimensionality, item difficulty, and category functioning. Two underlying scale dimensions, relatively high item difficulties, and a need for collapsing 2 response…

  19. Validation of the Beck Depression Inventory-II in a Low-Income African American Sample of Medical Outpatients

    Science.gov (United States)

    Grothe, Karen B.; Dutton, Gareth R.; Jones, Glenn N.; Bodenlos, Jamie; Ancona, Martin; Brantley, Phillip J.

    2005-01-01

    The psychometric properties of the Beck Depression Inventory-II (BDI-II) are well established with primarily Caucasian samples. However, little is known about its reliability and validity with minority groups. This study evaluated the psychometric properties of the BDI-II in a sample of low-income African American medical outpatients (N = 220).…

  20. The Beck depression inventory as a measure of subjective well-being : A cross-national study

    NARCIS (Netherlands)

    van Hemert, D.A.; van de Vijver, F.J.R.; Poortinga, Y.H.

    2002-01-01

    The present study examined the question whether the Beck Depression Inventory (BDI), which is one of the most widely used instruments to assess depression, can be used to measure differences in subjective well-being at national level. In order to establish the meaning of depression scores at country

  1. Psychometric Properties of the Beck Depression Inventory-II in a Clinically-Identified Sample of Mexican American Adolescents

    Science.gov (United States)

    VanVoorhis, Carmen R. Wilson; Blumentritt, Tracie L.

    2007-01-01

    We examined the internal consistency reliability, convergent and divergent validity, and factor structure of the Beck Depression Inventory-II (BDI-II) in a sample of 131 Mexican American youth. The BDI-II demonstrated excellent internal consistency reliability (alpha = 0.90) and solid convergent and divergent validity with various clinical scales…

  2. Psychometric Properties of the Beck Depression Inventory-II (BDI-II) among Community-Dwelling Older Adults

    Science.gov (United States)

    Segal, Daniel L.; Coolidge, Frederick L.; Cahill, Brian S.; O'Riley, Alisa A.

    2008-01-01

    The psychometric properties of the Beck Depression Inventory-II (BDI-II) as a self-administered screening tool for depressive symptoms were examined in a sample of community-dwelling older and younger adults. Participants completed the BDI-II, the Center for Epidemiologic Studies Depression Scale, the Coolidge Axis II Inventory, the Perceived…

  3. Exploring the Old Town School of Folk Music's Beck "Song Reader" Ensemble: An Interview with Nathaniel Braddock

    Science.gov (United States)

    Thibeault, Matthew D.

    2014-01-01

    This column presents an interview with Nathaniel Braddock, who created and teaches an ensemble devoted to Beck's "Song Reader" at the Old Town School of Folk Music in Chicago, Illinois. "Song Reader" is a collection of 20 compositions published as sheet music for musicians to record and release, with over 17,000 versions…

  4. [Beck Anxiety Inventory German Version - A Reliable, Valid, Patientfriendly Instrument for Measuring Clinical Anxiety].

    Science.gov (United States)

    Geissner, Edgar; Huetteroth, Anne

    2018-01-19

    The Beck Anxiety Inventory (BAI) is available in German. Apart from data in its manual, there are no further reports on the psychometric properties of this questionnaire and on its suitability for clinical use in Germany. This study therefore offers an independent investigation into the psychometrics as well as the clinical characteristics of the BAI. Three samples with n=145, n=90, and n=174 comprised inpatients diagnosed with anxiety disorders and treated in a large psychosomatic hospital. In addition to the BAI, the clinician rating Hamilton Anxiety Scale (HamA), the State-Trait-Anxiety Inventory (STAI) as well as the two anxiety subscales of the Symptom Checklist 90 (SCL 90) were used to establish convergent validity. For divergent validity, patients filled out questionnaires measuring the motivational construct of Action versus State Orientation as well as the motivational scale of the Freiburg Personality Inventory (FPI). The Beck Depression Inventory II (BDI II) and a single item targeting a patient's psychotherapy goal achievement complemented the measures. Data collection times were admission to inpatient treatment, discharge from the hospital, and 6-month follow-up. For a subsample of patients, additional data from the weeks prior to hospital admission allowed for a test of the nonspecific Hope for Success in the absence of therapy. The inpatient intervention consisted of approximately 6 weeks of cognitive-behavioral psychotherapy. The German BAI is considered to be unidimensional. It is a homogeneous, reliable (3-day test-retest) inventory with excellent item characteristics. The data suggested good convergent validity with other anxiety measures, and divergent validity. However, the BAI and the BDI-II exhibited a midrange correlation with each other, which was an unexpected result. Groups of patients with different diagnoses could be differentiated. The questionnaire shows sensitivity to specific and nonspecific change. Goal attainment goes along with

  5. Metafísica de la violencia y de la paz. Análisis agustiniano de una definición de Paul Gilbert

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    Diego I. Rosales Meana

    2017-07-01

    Full Text Available En este trabajo intentaré trazar los lineamientos básicos de una metafísica de la violencia y de la paz en Paul Gilbert y Agustín de Hipona. Para ello, explicitaré los postulados agustinianos sobre los que descansa una definición Gilbert da de la violencia en su libro La paciencia de ser. La definición de Gilbert se pondrá a prueba en tres pasos. En primer lugar, exploraré lo que implica hablar de la violencia en metafísica concebida ésta como una «filosofía primera». En segundo lugar, recuperaré la fenomenología que Agustín de Hipona elabora principalmente en De libero arbitrio. En tercer lugar analizaré la libertad política y su sustitución a través de la noción de «legalidad». De este modo, la violencia quedará caracterizada como la renuncia a lo propiamente político, como la afirmación unilateral de la libertad individual y, por lo tanto, la negación de esa misma libertad.

  6. Disease-modifying influences of coexistent G6PD-deficiency, Gilbert syndrome and deletional alpha thalassemia in hereditary spherocytosis: A report of three cases.

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    Jamwal, Manu; Aggarwal, Anu; Kumar, Verinder; Sharma, Prashant; Sachdeva, Man Updesh Singh; Bansal, Deepak; Malhotra, Pankaj; Das, Reena

    2016-07-01

    Hereditary spherocytosis (HS) is a common inherited hemolytic anemia characterized by heterogeneous clinical presentations with variable degrees of anemia, jaundice, splenomegaly and gallstones. Although the underlying genetic defects in red cell membrane proteins may explain many phenotypic variations, a proportion of variability may be due to other co-inherited factors like enzymopathies, thalassemias and Gilbert syndrome. Associations of HS with glucose-6-phosphate dehydrogenase (G6PD) deficiency and Gilbert syndrome in isolation have been reported previously. We describe 3 adult cases of HS with concomitant Gilbert syndrome and G6PD-Mediterranean mutations (2 hemizygous males, aged 15 and 35y and 1 heterozygous 25-y female). Two patients required multiple transfusions that required splenectomy for management. One patient (15y male) also carried the single gene alpha 4.2 deletion and was less symptomatic. These cases illustrate the importance of clinico-pathological correlation and judicious extended testing for various contributing factors that may modify the clinical course of HS patients. G6PD deficiency is also a common enzymopathy in India and can contribute to the phenotypic heterogeneity. Its recognition is important for advising avoidance of oxidizing drug exposure. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Occurrence of Hysterothylacium and Anisakis nematodes (Ascaridida: Ascaridoidea) in the tanaka's snailfish Liparis tanakae (Gilbert & Burke) (Scorpaeniformes: Liparidae).

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    Guo, Yan-Ning; Xu, Zhen; Zhang, Lu-Ping; Hu, Yong-Hong; Li, Liang

    2014-04-01

    The tanaka's snailfish Liparis tanakae (Gilbert & Burke) (Scorpaeniformes: Liparidae) is an economically important marine fish species in China. However, the helminth parasites of this fish are still poorly known. During a helminthological survey of Chinese marine fishes from 2011 to 2012, we revealed that L. tanakae was heavily infected with third-stage larvae and adults of ascaridoid nematodes (total prevalence 100% and mean intensity 82.3 nematodes per fish). Four species of third-stage larvae Hysterothylacium liparis Li, Xu & Zhang, 2007, H. aduncum (Rudolphi, 1802), Hysterothylacium fabri (Rudolphi, 1819), and Anisakis pegreffii (Campana-Rouget & Biocca, 1955) and a single species of adults H. liparis were differentiated and identified by morphological and molecular methods. The detailed morphology of the four species of third-stage larvae was also studied using light microscopy and scanning electron microscopy. The morphological and molecular characterization of the third-stage larvae of H. liparis was reported. Liparis tanakae represents a new host record for A. pegreffii and H. fabri. In addition, a new name, Hysterothylacium zhoushanense nom. nov. was also given to Hysterothylacium zhoushanensis Li, Liu & Zhang, 2012 to make the latinized specific epithet agree with this neuter generic name.

  8. Oncology Drug Dosing in Gilbert Syndrome Associated with UGT1A1: A Summary of the Literature.

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    Ha, Vincent H; Jupp, Jennifer; Tsang, Roger Y

    2017-08-01

    Gilbert syndrome (GS) is a hereditary condition that affects ~10% of the population. It is characterized by intermittent, unconjugated hyperbilirubinemia in the absence of hepatocellular damage and hemolysis. Although GS is often described as a benign laboratory finding, it may alter drug metabolism by decreasing the ability to conjugate drugs. Genetic polymorphisms, specifically the UGT1A1*28 allele, may reduce glucuronidation by 30% that severely impacts the ability to metabolize certain medications. Antineoplastic agents used in oncologic settings have toxic side effects, and alterations in metabolism may result in severe or even life-threatening toxicities. Many of the drug monographs provided by manufacturers contain dose adjustment parameters for hepatic function, using serum bilirubin as a surrogate marker. However, in patients with GS, hepatic function remains normal in the setting of hyperbilirubinemia, and scant literature is available to provide guidance on empirical dosage adjustment. In this review, we conducted a literature search of routinely used oncology medications and assessed the need for empirical dose adjustments in the setting of GS. © 2017 Pharmacotherapy Publications, Inc.

  9. Gilbert syndrome: the UGT1A1*28 promoter polymorphism as a biomarker of multifactorial diseases and drug metabolism.

    Science.gov (United States)

    Gil, Justyna; Sąsiadek, Maria M

    2012-04-01

    Gilbert syndrome belongs to the group of the most common human metabolic disorders and is characterized by an elevated level of bilirubin in blood serum. A polymorphism of the 5´ end of the UGT1A1 gene promoter, a homozygous insertion of TA pairs (genotype UGT1A1*28/*28), results in a decrease in bilirubin glucuronidation activity and therefore leads to an increase in the level of unconjugated bilirubin (hyperbilirubinemia). Genotyping the UGT1A1 promoter is an important step in the determination of the etiology of free hyperbilirubinemia of unknown origin. Molecular diagnosis enables avoiding invasive diagnostic procedures, such as liver biopsy, in establishing the appropriate diagnosis and prognosis, as well as in establishing the correct therapeutic procedures in a variety of diseases (e.g., chemotherapy or bone marrow transplantation). Moreover, the UGT1A1*28/*28 genotype has emerged as an important element in drug tolerance, as well as in multifactorial diseases, such as cancer. However, the role of this polymorphism is still not completely understood. In this review we have summarized current knowledge and attempted to propose directions for further research.

  10. Differential Functioning of the Chinese Version of Beck Depression Inventory-II in Adolescent Gender Groups: Use of a Multiple-Group Mean and Covariance Structure Model

    Science.gov (United States)

    Wu, Pei-Chen

    2010-01-01

    The objectives of this study were (a) to investigate whether items of the Chinese version of Beck Depression Inventory II (BDI-II-C; "Chinese Behavioral Science Corporation" in "Manual for the Beck Depression Inventory-II" [in Chinese]. The Chinese Behavioral Science Corporation, Taiwan, 2000) exhibited DIF across adolescent…

  11. Do scores on the Beck Depression Inventory-II predict outcome in cognitive processing therapy?

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    Asamsama, Octaviana Hemmy; Dickstein, Benjamin D; Chard, Kathleen M

    2015-09-01

    Current treatment guidelines for posttraumatic stress disorder (PTSD) recognize that severe depression may limit the effectiveness of trauma-focused interventions, making it necessary to address depression symptomatology first. However, there is a paucity of research providing specific treatment recommendations using a common depression measure like the Beck Depression Inventory-II (BDI-II). Accordingly, we examined the utility of using BDI-II cutoff scores for predicting response to cognitive processing therapy (CPT). Our sample was 757 military veterans receiving outpatient therapy at a Department of Veterans Affairs specialty clinic. At baseline, the majority of participants (58.9%) reported BDI-II scores suggestive of severe depression, and 459 (60.7%) met DSM-IV diagnostic criteria for major depressive disorder (MDD). Despite this high level of depression severity, most participants who completed therapy experienced a clinically significant reduction in symptoms (75.1%). No differences were observed across BDI-II groups on rates of clinically significant change in PTSD symptoms or on rates of treatment completion. Taken together, results suggest that CPT is an effective treatment, even in cases of severe co-occurring depression. Limitations and implications for treatment guidelines are discussed. (c) 2015 APA, all rights reserved).

  12. Meta-Analysis of the Factor Structures of the Beck Depression Inventory-II.

    Science.gov (United States)

    Huang, Chiungjung; Chen, Jyun-Hong

    2015-08-01

    Two meta-analyses examined the factor structure of the Beck Depression Inventory-II (BDI-II). Study 1, which meta-analyzed 51 studies comprising 62 samples (N = 20,475) providing pattern matrices, determined that the two-factor solution comprising Cognitive and Somatic-Affective factors was supported for the full sample. The two-factor solution was also supported for subgroups of studies. As the factor structure varied somewhat between subgroups of studies, the strength of relationships between scale items and their underlying depressive symptoms varied. Hence, comparisons of mean BDI-II scores across subgroups can be misleading. Study 2 meta-analyzed 13 studies consisting of 16 samples (N = 5,128) providing covariance matrices among the 21 BDI-II items. The two-factor solution was again supported in Study 2. Nevertheless, the existence of a general depression factor was supported by the good fit of the one-factor model. © The Author(s) 2014.

  13. Survey of depression by Beck Depression Inventory in uremic patients undergoing hemodialysis and hemodiafiltration.

    Science.gov (United States)

    Su, Shu-Fen; Ng, Hwee-Yeong; Huang, Tiao-Lai; Chi, Po-Jui; Lee, Yueh-Ting; Lai, Chun-Ren; Lin, Yau-Hsing; Huang, Pei-Chen; Lee, Chien-Te

    2012-12-01

    High prevalence of depression has been reported in patients with end stage kidney disease and depression is associated with increased morbidity and mortality. We aimed to investigate the prevalence of depression in patients receiving standard hemodialysis (SHD) and hemodiafiltration (HDF) and compare the associated factors between these treatment modalities. The Beck Depression Inventory (BDI) was used to survey for major depressive symptoms. Demographic and biochemical data were reviewed and collected. Point prevalence of depression in HDF patients was significantly lower than SHD patients (23.9% vs. 43.1%, P grip strength but had higher prevalence of diabetes and high sensitivity C-reactive protein (hs-CRP) levels. In HDF patients, phosphorus level was significantly lower in patients with major depressive symptoms. Logistic regression analysis revealed that hs-CRP, serum sodium and hand grip strength were significantly associated with major depressive symptoms in patients treated with SHD; while serum phosphorus was identified in HDF groups. We concluded that prevalence of depression was high in dialysis patients. Patients receiving HDF had a lower mean BDI score and a nearly 50% lower prevalence rate of major depressive symptoms than that of SHD. Factors associated with depression were different between two modalities. © 2012 The Authors. Therapeutic Apheresis and Dialysis © 2012 International Society for Apheresis.

  14. Normative Data on the Beck Depression Inventory--Second Edition (BDI-II) in College Students.

    Science.gov (United States)

    Whisman, Mark A; Richardson, Emily D

    2015-09-01

    This study was conducted to provide normative data on the Beck Depression Inventory--Second Edition (BDI-II) in college students. Data were obtained from 15,233 college students drawn from 17 universities in the United States, weighted to match the gender and race/ethnicity of enrollment in degree-granting institutions. Descriptive statistics, point prevalence of individuals exceeding cutoff scores, and mean differences by gender and race/ethnicity were provided. Because the distribution of BDI-II scores was not normal, percentile ranks for raw scores were provided for the total sample and separately by gender and race/ethnicity for the total sample and by race/ethnicity for men and women. Normative data were used to calculate the Reliable Change Index on the BDI-II for college students. Because the distribution of BDI-II scores demonstrated significant skewness and non-normal kurtosis, percentile ranks are important to consider in interpreting scores on the measure, in addition to descriptive statistics. © 2015 Wiley Periodicals, Inc.

  15. The essential oil of Thymus aureopunctatus (Beck) K. Malý.

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    Cavara, Sanja; Maksimović, Milka; Vidic, Danijela

    2009-03-01

    Essential oil of Thymus aureopunctatus (Beck) K. Malý, obtained by hydrodistillation and headspace technique, was subjected to capillary GC-MS analysis, and its volatile composition was compared with essential oil profile of Thymus serpyllum L. and a botanically undetermined thyme species, Thymus spp., all growing wild in the same habitat in Bosnia and Herzegovina. This paper presents the first report on phytochemical analysis of the rare T. aureopunctatus species, and also the first report on headspace analysis of plants belonging to the genus Thymus. One hundred and two volatile constituents were identified. The investigated Thymus species of Bosnian origin clearly belong to the thymol-chemotype with relatively abundant level of this main constituent varying from 30.5% for T. serpyllum, and 34.5% for T. aureopunctatus, to 44.2% for Thymus spp., while their corresponding headspace samples contain very high percentage of p-cymene, thymol biosynthesis precursor, in the range from 29.1% to 68.1%.

  16. Béatrix Beck: The “Barny Cycle”: Writing to Inform and Heal the Self

    Directory of Open Access Journals (Sweden)

    Myrna Bell Rochester

    2012-01-01

    Full Text Available To cope with the traumatic reality of World War II, French society repressed its memories, resulting in a false collective memory. Today, a more truthful history can be restored with the study of wartime and post-war texts. We examine the first six books (1948-67 of Belgian-French writer Béatrix Beck (1914-2008, alongside the theories of psychiatrist Judith Lewis Herman, who wrote that “traumatic reactions occur when action is of no avail.” Beck’s semi-autobiographical protagonist, Barny, goes through Herman’s stages of forgetting and remembering, healing and recovery. Her emergence as a writer also follows that trajectory: Barny, like Occupied France, was isolated. Helpless to act or react, she was traumatized—by her father’s death, a dysfunctional childhood, her mother’s suicide, and, in Occupied France, her husband’s death, single motherhood, poverty, menial jobs, and fear of arrest. In the first stage of recovery, Barny reaches safety. In the second, she begins to remember, to probe the issues and articulate them, in their painful ambiguity. For Herman, the ultimate goal is to put the story, with its imagery, into words. In the third stage, Barny, against fierce odds, becomes a writer.

  17. Symptom profiles in depersonalization and anxiety disorders: an analysis of the Beck Anxiety Inventory.

    Science.gov (United States)

    Nestler, Steffen; Jay, Emma-Louise; Sierra, Mauricio; David, Anthony S

    2015-01-01

    Depersonalization disorder (DPD) entails distressing alterations in self-experiencing. However, it has long been recognized that depersonalisation symptoms occur in other disorders, particularly anxiety and panic. One strand of research proposes that depersonalization phenomenology arises through altered autonomic arousal in response to stress. We sought to examine profiles of anxiety symptoms through a secondary data analysis of individual items and factor subscales on the Beck Anxiety Inventory (BAI), comparing two relatively large patient samples with DPD or with a variety of anxiety conditions, respectively. The DPD sample (n = 106) had a lower overall BAI score than the combined anxiety disorders group (n = 525). After controlling for this as well as for potential confounders such as age and gender, the DPD group presented significantly lower scores on the panic subscale, marginally lower scores on the autonomic subscale and significantly higher scores on the neurophysiological subscale of the BAI. These differences imply similarities between the cognitive components of DPD and anxiety disorders while physiological experiences diverge. The findings encourage future research looking at direct physiological measures and longitudinal designs to confirm the mechanisms underlying different clinical manifestations of anxiety. © 2014 S. Karger AG, Basel.

  18. Longitudinal Measurement Invariance of Beck Depression Inventory-II in Early Adolescents.

    Science.gov (United States)

    Wu, Pei-Chen

    2017-04-01

    This study explored the longitudinal measurement invariance in the Beck Depression Inventory-II (BDI-II) in early adolescents (junior high school students). The participants were 730 early adolescents (330 boys and 400 girls), who were followed up over 3 years (in six waves). To reduce the size of longitudinal model and verify the stability of the findings, the Fall and Spring series data sets were analyzed separately. Each series includes three waves of data with about 1-year apart. It was found that the three-factor model (Negative Attitude, Performance Difficulty, and Somatic Elements) best fitted the data. Results of both data sets provided support for the longitudinal measurement invariance (threshold invariance) of the three-factor model, suggesting that the BDI-II measured the same construct over 3 years. The study also examined the category function of the BDI-II on the basis of the pattern of threshold estimates. Finally, the implications of the findings on the continuing use of the BDI-II are discussed.

  19. Minimal clinically important difference on the Beck Depression Inventory--II according to the patient's perspective.

    Science.gov (United States)

    Button, K S; Kounali, D; Thomas, L; Wiles, N J; Peters, T J; Welton, N J; Ades, A E; Lewis, G

    2015-11-01

    The Beck Depression Inventory, 2nd edition (BDI-II) is widely used in research on depression. However, the minimal clinically important difference (MCID) is unknown. MCID can be estimated in several ways. Here we take a patient-centred approach, anchoring the change on the BDI-II to the patient's global report of improvement. We used data collected (n = 1039) from three randomized controlled trials for the management of depression. Improvement on a 'global rating of change' question was compared with changes in BDI-II scores using general linear modelling to explore baseline dependency, assessing whether MCID is best measured in absolute terms (i.e. difference) or as percent reduction in scores from baseline (i.e. ratio), and receiver operator characteristics (ROC) to estimate MCID according to the optimal threshold above which individuals report feeling 'better'. Improvement in BDI-II scores associated with reporting feeling 'better' depended on initial depression severity, and statistical modelling indicated that MCID is best measured on a ratio scale as a percentage reduction of score. We estimated a MCID of a 17.5% reduction in scores from baseline from ROC analyses. The corresponding estimate for individuals with longer duration depression who had not responded to antidepressants was higher at 32%. MCID on the BDI-II is dependent on baseline severity, is best measured on a ratio scale, and the MCID for treatment-resistant depression is larger than that for more typical depression. This has important implications for clinical trials and practice.

  20. Psychometric properties and validity of Beck Depression Inventory II in multiple sclerosis.

    Science.gov (United States)

    Sacco, R; Santangelo, G; Stamenova, S; Bisecco, A; Bonavita, S; Lavorgna, L; Trojano, L; D'Ambrosio, A; Tedeschi, G; Gallo, A

    2016-04-01

    Depression is the most common psychiatric disorder in multiple sclerosis (MS). Self-report depression scales are frequently used as screening, diagnostic and grading instruments. This study investigated the psychometric properties of the Beck Depression Inventory second edition (BDI-II) for assessing depressive disorders in a sample of Italian MS patients. The sample included 141 consecutive non-demented MS patients who completed the BDI-II and the Chicago Multiscale Depression Inventory (CMDI). MS patients also completed a clinical interview, a neurological/neuropsychological examination and a Fatigue Severity Score (FSS) questionnaire in order to assess divergent validity. The BDI-II showed good internal consistency (Cronbach's alpha 0.89) and good convergent and divergent validity. With respect to CMDI serving as the 'gold standard', the receiver operating characteristic curve revealed that BDI-II is an adequate diagnostic measure and that the optimum total cut-off score was 18.5. Such score identified clinically relevant depressive symptoms in 25.5% of our MS sample. The BDI-II is a simple, reliable and valid tool for detecting and grading depressive symptoms in Italian MS patients. © 2016 EAN.

  1. An investigation of the factor structure of the beck depression inventory-II in anorexia nervosa.

    Science.gov (United States)

    Fuss, Samantha; Trottier, Kathryn; Carter, Jacqueline

    2015-01-01

    Symptoms of depression frequently co-occur with eating disorders and have been associated with negative outcomes. Self-report measures such as the Beck Depression Inventory-II (BDI-II) are commonly used to assess for the presence of depressive symptoms in eating disorders, but the instrument's factor structure in this population has not been examined. The purposes of this study were to explore the factor structure of the BDI-II in a sample of individuals (N = 437) with anorexia nervosa undergoing inpatient treatment and to examine changes in depressive symptoms on each of the identified factors following a course of treatment for anorexia nervosa in order to provide evidence supporting the construct validity of the measure. Exploratory factor analysis revealed that a three-factor model reflected the best fit for the data. Confirmatory factor analysis was used to validate this model against competing models and the three-factor model exhibited strong model fit characteristics. BDI-II scores were significantly reduced on all three factors following inpatient treatment, which supported the construct validity of the scale. The BDI-II appears to be reliable in this population, and the factor structure identified through this analysis may offer predictive utility for identifying individuals who may have more difficulty achieving weight restoration in the context of inpatient treatment. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.

  2. [Reliability and validity of the Revised Beck Depression Inventory (BDI-II). Results from German samples].

    Science.gov (United States)

    Kühner, C; Bürger, C; Keller, F; Hautzinger, M

    2007-06-01

    The Beck Depression Inventory (BDI) underwent revision in 1996 (BDI-II) with the goal of addressing DSM-IV depression criteria. The present study assessed psychometric properties of the German version of the BDI-II. The BDI-II was translated into German and evaluated in a series of studies with clinical and nonclinical samples. The content validity of the BDI-II has improved by following DSM-IV symptom criteria. Internal consistency was satisfactorily high (alpha>or=0.84), and retest reliability exceeded r>or=0.75 in nonclinical samples. Associations with construct-related scales (depression, dysfunctional cognitive constructs) were high, while those with nonsymptomatic personality assessment (NEO-FFI) were lower. The BDI-II differentiated well between different grades of depression and was sensitive to change. The German BDI-II demonstrates good reliability and validity in clinical and nonclinical samples. It may now replace the older version of the BDI for assessing self-rated severity of depression and course of depressed symptoms under treatment.

  3. Does the Beck Cognitive Insight Scale Predict Response to Cognitive Remediation in Schizophrenia?

    Science.gov (United States)

    Benoit, Audrey; Harvey, Philippe-Olivier; Bherer, Louis; Lepage, Martin

    2016-01-01

    Cognitive remediation therapy (CRT) has emerged as a viable treatment option for people diagnosed with schizophrenia presenting disabling cognitive deficits. However, it is important to determine which variables can influence response to CRT in order to provide cost-effective treatment. This study's aim was to explore cognitive insight as a potential predictor of cognitive improvement after CRT. Twenty patients with schizophrenia completed a 24-session CRT program involving 18 hours of computer exercises and 6 hours of group discussion to encourage generalization of cognitive training to everyday activities. Pre- and posttest assessments included the CogState Research Battery and the Beck Cognitive Insight Scale (BCIS). Lower self-certainty on the BCIS at baseline was associated with greater improvement in speed of processing (r s = -0.48; p cognitive improvement after CRT, a variable that can easily be measured in clinical settings to help evaluate which patients may benefit most from the intervention. They also underline the need to keep investigating the predictors of good CRT outcomes, which can vary widely between patients.

  4. Pattern of joints involvement in Kashin-Beck disease: a local osteochondropathy in China.

    Science.gov (United States)

    Farooq, Umer; Xiong, Guo; Irshad, Romana; Yaqoob, Shehzad

    2010-01-01

    Kashin-Beck Disease (KBD) is an endemic osteochondropathy. The disease starts in childhood and attacks the growth of joint cartilage, the joints become deformed and painful, and the worst forms result in dwarfism. The most fiequent joints involved are the finger, wrist, ankles, knees and elbows. In this study the pattern of joints involved in KBD was studied. A total of 368 patients aged above 13 from 6 villages in endemic areas of the Shaanxi province, located in the northwest of China, were selected through multistage stratified sampling. The patients were diagnosed based on the clinical criteria for diagnosis of KBD. The patients were administered with a battery of questionnaires along with clinical examination for joint involvement. The patients presented both as oligoarticular as well as polyarticular pattern. Smaller joints were more frequently involved with a proximal-distal pattern. The number of joints involved increased with the severity of the disease. Proximal smaller joints are more frequently involved in the disease. The involvement of bigger joints takes place in later stages of disease, i.e., in the second and third degree. The pattern of joint involvement shows some correlation with Rheumatoid Arthritis which needs further investigation and comparative studies.

  5. Modified Becke-Johnson exchange potential: improved modeling of lead halides for solar cell applications

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    Radi A. Jishi

    2016-01-01

    Full Text Available We report first-principles calculations, within density functional theory, on the lead halide compounds PbCl2, PbBr2, and CH3NH3PbBr3−xClx, taking into account spin-orbit coupling. We show that, when the modified Becke-Johnson exchange potential is used with a suitable choice of defining parameters, excellent agreement between calculations and experiment is obtained. The computational model is then used to study the effect of replacing the methylammonium cation in CH3NH3PbI3 and CH3NH3PbBr3 with either N2H5+or N2H3+, which have slightly smaller ionic radii than methylammonium. We predict that a considerable downshift in the values of the band gaps occurs with this replacement. The resulting compounds would extend optical absorption down to the near-infrared region, creating excellent light harvesters for solar cells.

  6. [Study of depressiveness with Beck Depression Inventory in patients with cardiac arrhythmias].

    Science.gov (United States)

    Hajduk, Anna; Korzonek, Maria; Przybycień, Krzysztof; Ertmański, Sławomir; Stolarek, Jolanta

    2011-01-01

    Atrial fibrillation belongs to the group of supraventricular arrhythmias. The episode begins with anxiety about the loss of health or life. Anxiety is accompanied by depressive disorders. The aim of this work was to study the intensity of depression in patients with atrial fibrillation. We used Beck Depression Inventory in 52 patients with atrial fibrillation hospitalized at the Department of Internal Medicine of the Poviat Hospital in Białogard. Correlations between the intensity of depression and age, gender, and education level were determined. The intensity of depression depended on age, gender, and education level. Mild depression was more common in women, moderate in men, and was very severe in 2 women. Patients between the age of 61 and 80 years and with incomplete primary and vocational education presented with all forms of depression. The intensity of depression correlates with episodes of atrial fibrillation and depends on such factors as age, gender, and education level (p Effective therapy of atrial fibrillation may help reduce the intensity of depression.

  7. Interrogating the Becke'05 density functional for non-locality information

    Science.gov (United States)

    Dale, Stephen G.; Johnson, Erin R.; Becke, Axel D.

    2017-10-01

    In two papers, Becke [J. Chem. Phys. 119, 2972 (2003) and J. Chem. Phys. 122, 064101 (2005)] introduced Kohn-Sham density-functional approximations for static and dynamical correlation to be partnered with 100 percent exactly computed exchange. Known as "B05," this was the first non-local correlation model designed to work with the full non-locality of exact (or Hartree-Fock) exchange. Non-locality issues, often referred to as the "delocalization" problem, are among the most vexing problems in density-functional theory today. How much exact exchange should be used in a hybrid functional? What value of the range parameter should be used in a long-range corrected functional? Questions such as these abound, and the answers are system dependent. The physics of non-locality is built into the B05 functional in a natural way, and one wonders, therefore, if B05 might provide a mechanism to answer such questions. Here we explore a variational procedure, "B05min," to do so. We compute dipole moments of 52 small molecules and find that B05min delivers better moments than parent hybrid and long-range corrected functionals. Furthermore, B05min provides a priori optimum exact-exchange mixing fractions and range parameters for the parent functionals, whose values agree with literature values fit to experimental data.

  8. Psychometric Properties of the Persian Version of the Short Beck Depression Inventory with Iranian Psychiatric Outpatients

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    Mahboubeh Dadfar

    2016-01-01

    Full Text Available The short form of the Beck Depression Inventory (BDI-13 is useful for the screening and assessment of depression in clinical and research settings. The aim of the present study was to investigate the psychometric properties of the Persian (Farsi version of BDI-13 in an Iranian clinical sample. The sample consisted of 52 Iranian psychiatric outpatients who received services at psychiatric and psychological clinics at the School of Behavioral Sciences & Mental Health-Tehran Institute of Psychiatry, Iran University of Medical Sciences (IUMS in Tehran, Iran. The study examined the reliability, construct validity, and factor structure of the instrument. The instrument indicated good reliability with Cronbach’s alpha of .85 and strong construct validity based on moderate to strong positive correlations with other measures of mental health issues. Using a Principal Component Analysis and Varimax Rotation with Kaiser Normalization, three factors were identified and labeled Affective (F1, Somatic/Vegetative (F2, and Cognitive/Loss of Functioning (F3. The current factor structure suggests that depression is a multidimensional construct in an Iranian clinical sample. This study provides further evidence that the Persian version of the BDI-13 is a psychometrically sound instrument that can be used for clinical and research purposes in Iran.

  9. Does the Beck Cognitive Insight Scale Predict Response to Cognitive Remediation in Schizophrenia?

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    Audrey Benoit

    2016-01-01

    Full Text Available Cognitive remediation therapy (CRT has emerged as a viable treatment option for people diagnosed with schizophrenia presenting disabling cognitive deficits. However, it is important to determine which variables can influence response to CRT in order to provide cost-effective treatment. This study’s aim was to explore cognitive insight as a potential predictor of cognitive improvement after CRT. Twenty patients with schizophrenia completed a 24-session CRT program involving 18 hours of computer exercises and 6 hours of group discussion to encourage generalization of cognitive training to everyday activities. Pre- and posttest assessments included the CogState Research Battery and the Beck Cognitive Insight Scale (BCIS. Lower self-certainty on the BCIS at baseline was associated with greater improvement in speed of processing (rs=-0.48; p<0.05 and visual memory (rs=-0.46; p<0.05. The results of this study point out potential associations between self-certainty and cognitive improvement after CRT, a variable that can easily be measured in clinical settings to help evaluate which patients may benefit most from the intervention. They also underline the need to keep investigating the predictors of good CRT outcomes, which can vary widely between patients.

  10. Correlação entre Inventário de Depressão de Beck e cortisol urinário em diabéticos tipo 2 Correlación entre el inventario de Depresión de Beck y el cortisol urinario en diabeticos tipo 2 Correlation between urine cortisol and scores on the Beck Depression inventory in patients with type 2 diabetes

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    Alexandra Bulgarelli do Nascimento

    2009-01-01

    Full Text Available OBJETIVO: Verificar a correlação entre o cortisol urinário e o Inventário de Depressão de Beck em diabéticos do tipo 2. MÉTODOS: O cortisol urinário foi avaliado em uma amostra composta por 40 pacientes da Liga de Controle de Diabetes da Disciplina de Endocrinologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo e para a avaliação dos sintomas de depressão foi aplicado o Inventário de Depressão de Beck. RESULTADOS: Alta confiabilidade para o Inventário de Depressão de Beck(Alfa de Cronbach=0,920e correlação significativa foi observada entre cortisol urinário e Inventário de Depressão de Beck(Spearman,r=0.523,pOBJETIVO: Verificar la correlación entre el cortisol urinario y el Inventario de Depresión de Beck en diabéticos del tipo 2. MÉTODOS: El cortisol urinario fue evaluado en una muestra compuesta por 40 pacientes de la Liga de Control de Diabetes de la Disciplina de Endocrinología del Hospital de las Clínicas de la Facultad de Medicina de la Universidad de Sao Paulo y para la evaluación de los síntomas de depresión fue aplicado el Inventario de Depresión de Beck. RESULTADOS: Alta confiabilidad para el Inventario de Depresión de Beck(Alfa de Cronbach=0,920 y correlación significativa observada entre el cortisol urinario e Inventario de Depresión de Beck (Spearman,r=0.523,pOBJECTIVE: To determine the relationship between urinary cortisol and scores on the Beck Depression Inventory in type 2 diabetics. METHODS: The sample consisted of 40 patients with type 2 diabetes from the diabetes control league of the discipline of endocrinology of the HCFM-USP. Measures consisted of urinary cortisol and depression symptoms using the Beck Depression Inventory. RESULTS: The Beck Depression Inventory had a Cronbach's alpha of 0.92. There was a statistically significant correlation between urinary cortisol and scores on the Beck Depression Inventory (Spearman r = 0.52, p < .001. CONCLUSIONS: The

  11. Funcionamento Diferencial do Item no Inventário de Depressão Beck

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    Stela Maris de Jezus Castro

    2015-03-01

    Full Text Available INTRODUÇÃO: Diversos estudos mostram o Funcionamento Diferencial do Item (DIF em itens do Inventário de Depressão Beck (BDI, ao compararem homens e mulheres. A presença de um grande número de itens com DIF no BDI é uma severa ameaça à validade da medida da intensidade de sintomas depressivos obtida pela Teoria da Resposta ao Item (TRI e às conclusões baseadas nos escores derivados dos itens com e sem DIF. OBJETIVO: Os objetivos deste estudo foram identificar esses itens do BDI, ajustar o modelo de TRI para itens constrangedores (modelo 2, o qual acomoda itens com a presença de DIF, e comparar esses resultados com os do ajuste do modelo logístico de dois parâmetros tradicional da TRI (modelo 1. MÉTODOS: Os resultados obtidos com ambos os modelos foram comparados. RESULTADOS: Os itens que apresentaram DIF foram: tristeza, sentimento de fracasso, insatisfações, culpa, punição, choro, fatigabilidade e perda da libido. Os resultados do ajuste dos dois modelos são similares quanto à discriminação, gravidade (à exceção dos itens com DIF e no cálculo de escores para os indivíduos. Apesar disso, o modelo 2 é vantajoso, pois mostra as diferenças em gravidade do sintoma depressivo para os grupos avaliados, trazendo, dessa forma, mais informação ao pesquisador sobre a população estudada. CONCLUSÃO: Esse modelo, que tem um alcance mais amplo em termos de população-alvo, pode ser uma ótima alternativa na identificação e acompanhamento de indivíduos com potencial depressivo.

  12. Disordered glycometabolism involved in pathogenesis of Kashin–Beck disease, an endemic osteoarthritis in China

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Cuiyan, E-mail: xj.cy.69@stu.xjtu.edu.cn [School of Public Health, Health Science Centre of Xi' an Jiaotong University, No. 76 Yanta West Road, Xi' an, Shaanxi 710061 (China); Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education (China); Key Laboratory of Trace elements and Endemic Diseases, Ministry of Health, Xi' an, Shaanxi 710061 (China); Lei, Ronghui, E-mail: leirh@mail.xjtu.edu.cn [School of Public Health, Health Science Centre of Xi' an Jiaotong University, No. 76 Yanta West Road, Xi' an, Shaanxi 710061 (China); Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education (China); Key Laboratory of Trace elements and Endemic Diseases, Ministry of Health, Xi' an, Shaanxi 710061 (China); Tiainen, Mika, E-mail: mika.tiainen@uef.fi [School of Pharmacy, University of Eastern Finland, Kuopio (Finland); Wu, Shixun, E-mail: wushixun313@stu.xjtu.edu.cn [School of Public Health, Health Science Centre of Xi' an Jiaotong University, No. 76 Yanta West Road, Xi' an, Shaanxi 710061 (China); Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education (China); Key Laboratory of Trace elements and Endemic Diseases, Ministry of Health, Xi' an, Shaanxi 710061 (China); Zhang, Qiang, E-mail: wdrr@163.com [Department of Kashin–Beck Disease, Qinghai Institute for Endemic Disease Control and Prevention, Xining, Qinghai 811602 (China); Pei, Fuxing, E-mail: peifuxing@vip.163.com [Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041 (China); Guo, Xiong, E-mail: guox@mail.xjtu.edu.cn [School of Public Health, Health Science Centre of Xi' an Jiaotong University, No. 76 Yanta West Road, Xi' an, Shaanxi 710061 (China); Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education (China); Key Laboratory of Trace elements and Endemic Diseases, Ministry of Health, Xi' an, Shaanxi 710061 (China)

    2014-08-15

    Kashin–Beck disease (KBD) is a chronic endemic osteoarthritis in China. Previous studies have suggested a role of metabolic dysfunction in causation of this disease. In this investigation, the metabolomics approach and cell experiments were used to discover the metabolic changes and their effects on KBD chondrocytes. Nuclear magnetic resonance ({sup 1}H NMR) spectroscopy was used to examine serum samples from both the KBD patients and normal controls. The pattern recognition multivariate analysis (OSC–PLS) and quantitative analysis (QMTLS iterator) revealed altered glycometabolism in KBD, with increased glucose and decreased lactate and citrate levels. IPA biological analysis showed the centric location of glucose in the metabolic network. Massive glycogen deposits in chondrocytes and increased uptake of glucose by chondrocytes further confirmed disordered glycometabolism in KBD. An in vitro study showed the effects of disordered glycometabolism in chondrocytes. When chondrocytes were treated with high glucose, expression of type II collagen and aggrecan were decreased, while TNF-α expression, the level of cellular reactive oxygen species and cell apoptosis rates all were increased. Therefore, our results demonstrated that disordered glycometabolism in patients with KBD was linked to the damage of chondrocytes. This may provide a new basis for understanding the pathogenesis of KBD. - Highlights: • Disordered glycometabolism in KBD was demonstrated by combining serum metabolomics and chondrocyte studies. • Glucose and TNF-α were key molecules linked to altered metabolism and inflammation in the pathophysiology of KBD. • The glycometabolism disorder was linked to expression of type II collagen and aggrecan, ROS and apoptosis of KBD chondrocytes.

  13. Whole-exome sequencing for the identification of susceptibility genes of Kashin-Beck disease.

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    Zhenxing Yang

    Full Text Available OBJECTIVE: To identify and investigate the susceptibility genes of Kashin-Beck disease (KBD in Chinese population. METHODS: Whole-exome capturing and sequencing technology was used for the detection of genetic variations in 19 individuals from six families with high incidence of KBD. A total of 44 polymorphisms from 41 genes were genotyped from a total of 144 cases and 144 controls by using MassARRAY under the standard protocol from Sequenom. Association was applied on the data by using PLINK1.07. RESULTS: In the sequencing stage, each sample showed approximately 70-fold coverage, thus covering more than 99% of the target regions. Among the single nucleotide polymorphisms (SNPs used in the transmission disequilibrium test, 108 had a p-value of <0.01, whereas 1056 had a p-value of <0.05. Kyoto Encyclopedia of Genes and Genomes(KEGG pathway analysis indicates that these SNPs focus on three major pathways: regulation of actin cytoskeleton, focal adhesion, and metabolic pathways. In the validation stage, single locus effects revealed that two of these polymorphisms (rs7745040 and rs9275295 in the human leukocyte antigen (HLA-DRB1 gene and one polymorphism (rs9473132 in CD2-associated protein (CD2AP gene have a significant statistical association with KBD. CONCLUSIONS: HLA-DRB1 and CD2AP gene were identified to be among the susceptibility genes of KBD, thus supporting the role of the autoimmune response in KBD and the possibility of shared etiology between osteoarthritis, rheumatoid arthritis, and KBD.

  14. Aaron Temkin BECK: After Cricitical Thinking to A Creative Psychotherapy Theory

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    Mehmet DİNÇ

    2012-07-01

    Full Text Available There is growing interest in the cognitive psychotherapy all around the world including Turkey. According to American Institute of Cognitive Therapy; cognitive psychotherapy is the fastest growing and most rigorously studied kind of talk therapy and it is practiced around the world, taking hold in places from the Middle East to Japan. Cognitive psychotherapy was designed first by Aaron Temkin Beck in 1950’s. He has published over 450 articles and authored or co-authored seventeen books and he has been listed as one of the “10 individuals who shaped the face of American Psychiatry” and one of the 5 most influential psychotherapists of all time since then. Beck’s groundbreaking systematic research established for the first time the efficacy of any psychotherapy for the treatment of depression. Moreover he not only developed and tested an effective short-term treatment (cognitive therapy for depression, but he and his former students have successfully adapted cognitive therapy to a wide range of other psychiatric disorders as well. Numerous controlled clinical trials have now demonstrated that cognitive therapy is effective in a variety of psychiatric conditions including depression, bulimia nervosa, hypochondriasis, social phobia, obsessive-compulsive disorder, substance abuse, body dysmorphic disorder, and post-traumatic stress disorder. Therefore knowing the father of cognitive therapy and his journey from 1950’s to 2010’s will help to understand cognitive therapy and its development during these years. This article aims to give an overview of the historical background to contemporary cognitive and cognitive-behavioral approaches to psychotherapy by focusing on Beck’s life, characteristics and works.

  15. Band gaps from the Tran-Blaha modified Becke-Johnson approach: a systematic investigation.

    Science.gov (United States)

    Jiang, Hong

    2013-04-07

    The semi-local Becke-Johnson (BJ) exchange-correlation potential and its modified form proposed by Tran and Blaha (TB-mBJ) have attracted a lot of interest recently because of the surprisingly accurate band gaps they can deliver for many semiconductors and insulators. In this work, we have investigated the performance of the TB-mBJ potential for the description of electronic band structures in a comprehensive set of semiconductors and insulators. We point out that a perturbative use of the TB-mBJ potential can give overall better results. By investigating a set of IIB-VI and III-V semiconductors, we point out that although the TB-mBJ approach can describe the band gap of these materials quite well, the binding energies of semi-core d-states in these materials deviate strongly from experiment. The difficulty of the TB-mBJ potential to describe the localized states is likely the cause for the fact that the electronic band structures of Cu2O and La2O3 are still poorly described. Based on these observations, we propose to combine the TB-mBJ approach with the Hubbard U correction for localized d∕f states, which is able to provide overall good descriptions for both the band gaps and semi-core states binding energies. We further apply the approach to calculate the band gaps of a set of Ti(IV)-oxides, many of which have complicated structures so that the more advanced methods like GW are expensive to treat directly. An overall good agreement with experiment is obtained, which is remarkable considering its little computational efforts compared to GW.

  16. Self, friends, and lovers: structural relations among Beck Depression Inventory scores and perceived mate values.

    Science.gov (United States)

    Kirsner, Beth R; Figueredo, Aurelio José; Jacobs, W Jake

    2003-07-01

    We used an economic model based on evolutionary theory to guide an examination of relations among self-reported depressive symptoms and ratings of mate values of self, social, and sexual partners. This model treats assortative mating as a form of social exchange between partners of socially and sexually desirable traits. Two studies used variants of the Mate Value Inventory (MVI), a multivariate assessment of attributes desired in social or sexual partners. For study 1, 115 male and 124 female undergraduates provided self reports on four forms of the MVI-11 and on the Beck Depression Inventory (BDI); for study 2, 208 male and 277 female undergraduates provided self reports on seven forms of the MVI-7 and on the BDI-II. Both multisample structural equations models indicated that the parameters were statistically equivalent between female and male subsamples and provided an adequate fit to the data. The models revealed significant relations between the mate values ascribed to the self and those ascribed to short- and long-term partners as well as best friends. Furthermore, greater BDI scores significantly predicted lesser ratings of mate value for the self, and hence indirectly predicted lesser ratings of mate value for all types of partners evaluated. Although the data obtained from the MVI demonstrated good psychometric validity, external validity has not yet been established. The results are consistent with models predicting: (1) assortative mating by mate value, (2) differential exchange rates of mate value for different types of partners, (3) a negative relation between depressive symptoms and assessment of one's own mate value, and (4) a possibly consequential mismatch of mate values when one partner exhibits or recovers from significant depressive symptoms. The results are inconsistent with models predicting (5) a generalized negativity bias due to depression.

  17. [Depression in Acute Coronary Syndromes: Application of the Beck Depression Inventory].

    Science.gov (United States)

    Arevalo, Jimmy J; Soto, Karen A; Caamaño, Beatriz

    2014-03-01

    Depression has been related to the occurrence of cardiovascular diseases, and also appears to increase the risk of death from coronary artery disease. The presence of depression after the occurrence of an acute coronary syndrome (ACS) and its relationship with socioeconomic factors has not been studied in Colombia. To describe the frequency of depression and associated factors in patients hospitalized with an ACS. A cross-sectional study was carried out between April and May 2008 in three coronary care units in Santa Marta, Colombia. The presence of depression was evaluated with the Beck Depression Inventory (BDI). Depression was considered to be present if BDI was equal or greater than 10. The relationship between the presence of depression and demographic, clinic and laboratory characteristics was analyzed. A BDI score ≥10 (any degree of depression) was seen in 21 (63.64%) of the patients. In 9 out of 10 (91.66%) patients without stable income had depression in contrast to 12 out of 23 (57.14%) with stable income (P=.037). Depression was found in in 8 of the 8 (100%) patients with electrocardiographic pathological T wave inversion, in contrast to 13 out of the 25 (52%) without changes in T wave (P=.014). Depression was detected in 17 of 22 (77.27%) patients who smoked cigarettes versus 4 of 11 (36.36%) of patients who have never smoked (P=.021). Depressive symptoms are significantly present in patients suffering an acute coronary syndrome. Unemployment, pathological T wave inversion, and smoking seem to be associated with the presence of depressive symptoms after an acute coronary event. Copyright © 2014 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  18. Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab.

    Science.gov (United States)

    Lee, Janet S; Wang, Jianmei; Martin, Mitchell; Germer, Soren; Kenwright, Andrew; Benayed, Ryma; Spleiss, Olivia; Platt, Adam; Pilson, Robert; Hemmings, Andrew; Weinblatt, Michael E; Kaplowitz, Neil; Krasnow, Joel

    2011-07-01

    Tocilizumab, a monoclonal antibody to interleukin-6 receptor, was recently approved for the treatment of moderate-to-severe rheumatoid arthritis. Two patients during clinical development met laboratory, but not clinical, criteria for Hy's law with bilirubin elevations suspected as a result of genetic variation in uridine diphosphoglucose glucuronosyltransferase (UGT1A1) typical of Gilbert syndrome. Genotyping of the two cases potentially meeting with Hy's law was performed using commercially available procedures. UGT1A1 single nucleotide polymorphism data were extracted from a genome-wide array database for 1187 patients from tocilizumab trials, and associations of UGT1A1 genotypes with bilirubin elevations were analyzed using logistic regression for associations with baseline and change from baseline in bilirubin levels as continuous variables. Bilirubin elevations were not associated with clinical adverse events. Both patients potentially meeting Hy's law carry homozygous UGT1A1*28 alleles and UGT1A1*60 alleles. UGT1A1*28 and three additional single nucleotide polymorphisms showed odds ratios greater than 25 for associations with elevated bilirubin. The presence of rs6742078 accounted for 32% of the total variance in bilirubin (P=2.2×10). Bilirubin increases occurring with tocilizumab appear to be related to anti-inflammatory effects extending to the liver. Thus, in the absence of other signs of hepatic dysfunction, bilirubin elevations after treatment with tocilizumab have a high probability of association with UGT1A1 polymorphism, which should alleviate concerns of serious hepatotoxicity. Our results underscore the value of genotyping in the clinical trial setting to avoid misinterpretations that could lead to terminating development of a promising new agent.

  19. Frequency of the UGT1A1*28 Polymorphism in a Romanian Cohort of Gilbert Syndrome Individuals.

    Science.gov (United States)

    Radoi, Viorica E; Ursu, Radu I; Poenaru, Elena; Arsene, Cosmin; Bohiltea, Camil L; Bohiltea, Roxana

    2017-03-01

    Gilbert syndrome (GS) is characterized by unconjugated hyperbilirubinemia without liver disease or overt hemolysis and it is found in 3-10% of the general population. Inherited hyperbilirubinaemia is attributable to a reduced UGT1A1 activity. The UGT1A1 promoter (TA) repeats variants are documented of being involved in abnormally elevated bilirubin levels. The aim of the present study is to analyze the impact of UGT1A1 promoter variants on bilirubin levels in Romanian patients clinically supected with GS. The study group included 897 subjects: 292 GS patients and 605 healthy controls. Genomic DNA was extracted from the peripheral blood leukocytes. All individuals were screened for the presence of the (TA) insertion in the TATA box region of UGT1A1 gene by PCR amplification. This case-control study was conducted at the Department of Medical Genetics, Synevo, Romania. UGT1A1*28 (7TA) revealed the highest frequency (61.87%) of all individuals, while the UGT1A1*1 (6TA) allele was found in 36.79%. We identified two other variants of the UGT1A1 gene, depending on the number of TA repeats in the promoter: 5TA (0.61%) and 8TA (0.72%). The (TA)7/7 homozygous genotype was identified in 32.33% of all individuals, while the (TA)6/7 heterozygous genotype was the most prevalent (57.64%). The wild type (TA)6/6 was identified in 7.36% of the whole cohort. Because other polymorphisms have been associated with GS, the absence of the UGT1A1*28 allele does not rule out this condition. The results suggest that in the Romanian population there is a strong correlation between the UGT1A1*28 polymorphism and hyperbilirubinemia in patients with GS.

  20. A generalized Grubbs-Beck test statistic for detecting multiple potentially influential low outliers in flood series

    Science.gov (United States)

    Cohn, T.A.; England, J.F.; Berenbrock, C.E.; Mason, R.R.; Stedinger, J.R.; Lamontagne, J.R.

    2013-01-01

    he Grubbs-Beck test is recommended by the federal guidelines for detection of low outliers in flood flow frequency computation in the United States. This paper presents a generalization of the Grubbs-Beck test for normal data (similar to the Rosner (1983) test; see also Spencer and McCuen (1996)) that can provide a consistent standard for identifying multiple potentially influential low flows. In cases where low outliers have been identified, they can be represented as “less-than” values, and a frequency distribution can be developed using censored-data statistical techniques, such as the Expected Moments Algorithm. This approach can improve the fit of the right-hand tail of a frequency distribution and provide protection from lack-of-fit due to unimportant but potentially influential low flows (PILFs) in a flood series, thus making the flood frequency analysis procedure more robust.

  1. Measuring Depression in a Non-Western War-Affected Displaced Population: Measurement Equivalence of the Beck Depression Inventory

    OpenAIRE

    Nuwan Jayawickreme; Jay Verkuilen; Eranda Jayawickreme; Kaylaliz Acosta; Foa, Edna B.

    2017-01-01

    Depression is commonly seen in survivors of conflict and disaster across the world. There is a dearth of research on the validity of commonly used measures of depression in these populations. Measurements of depression that are used in multiple contexts need to meet measurement equivalence, i.e., the instrument measures the same construct in the same manner across different groups. The Beck Depression Inventory (BDI) was administered to female trauma survivors in the United States (n = 268) a...

  2. Prevalence of depression and its associated factors using Beck Depression Inventory among students of a medical college in Karnataka

    OpenAIRE

    Ganesh S Kumar; Jain, Animesh; Hegde, Supriya

    2012-01-01

    Background and Objective: Depression among medical students is an area of increasing concern worldwide. This study aimed to assess the prevalence of depression and its associated factors among medical students. Materials and Methods: A stratified random sample of 400 students was assessed using Beck Depression Inventory by investigators. Associations between depression and class of studying, social factors like alcohol use, drug addiction, family problems, family history of depression, and st...

  3. Inventários Beck para crianças e adolescentes: revisão sistemática da literatura

    OpenAIRE

    Morais, Résia Silva de

    2014-01-01

    A teoria/terapia cognitiva (TC) promoveu profundas mudanças na psiquiatria e psicologia colaborando, assim, para o tratamento de uma ampla variedade de transtornos. Em termos diagnósticos, a TC faz uso de escalas psicométricas e de outros instrumentos. Por exemplo, em 1961, Beck desenvolveu as Escalas de Depressão de Beck (BDI) revisadas em 1978 (BDI-1A) e em 1996 a BDI-II foi publicada. Em 2001, elaborou o Beck Youth Inventory - (BYI-II) para crianças e adolescentes com idades entre 7 a 18 a...

  4. Once Upon A Journey - Travel Narratives by Women: The Philosophical Observations of Mary Wollstonecraft and the Cultural Meme of Elizabeth Gilbert

    OpenAIRE

    Faris, Reema

    2015-01-01

    This work analyzes travel writing by Mary Wollstonecraft and Elizabeth Gilbert to demonstrate that travel by women serves as a technology of the self or a means by which to attain a certain state of being. This examination of travel narratives from two different eras also reflects a shift in the nature of travel from a knowledge-expanding endeavour to a self-indulgent one prioritizing individual benefits. This emergent emphasis on travel as a means to self-improvement rather than self-under...

  5. EL «DE MODO ADDISCENDI» (C.1263) DE GILBERT DE TOURNAI O.F.M., UN PUENTE ENTRE LA TRADICIÓN Y EL RENACIMIENTO

    OpenAIRE

    Javier Vergara

    2013-01-01

    El renacimiento cultural que se produce en los siglos XII y XIII dio origen a una producción literaria abundante que tuvo en la educación uno de sus ejes más significativos. Un ejemplo patente es el De modo addiscendi, obra publicada hacia 1263, por el franciscano Gilbert de Tournai, en la que se resume una buena parte de la pedagogía escolástica. La obra, no traducida a lengua viva y apenas estudiada por la historiografía pedagógica, tiene por objeto mostrar cómo el maestro y el discípulo de...

  6. First-principles calculation of the effects of tetragonal distortions on the Gilbert damping parameter of Co2MnSi

    OpenAIRE

    Pradines, B; Arras, R.; Calmels, L

    2017-01-01

    We present an ab initio study of the influence of the tetragonal distortion, on the static and dynamic (Gilbert damping parameter) magnetic properties of a Co2MnSi crystal. This tetragonal distortion can for instance be due to strain, when Co2MnSi is grown on a substrate with a small lattice mismatch. Using fully relativistic Korringa-Kohn-Rostoker (KKR) calculations, in conjunction with the coherent potential approximation (CPA) to describe atomic disorder and the linear response formalism t...

  7. Prevalencia de síndrome de Gilbert y sus determinantes genéticas en población chilena

    OpenAIRE

    Méndez,Luis; Lagoa,Marcela; Quiroga,Teresa; Margozzini,Paula; Azócar,Lorena; Molina,Héctor R; Vera,Alejandra; Villarroel,Luis; Arrese,Marco; Hampe,Jochen; Buch,Stephan; Miquel,Juan F

    2013-01-01

    Background: In Europeans the TATA box TA7 repeat promoter variant in the UGT1A1 gene (UGT1A1*28) is the major determinant of bilirubin levels. Aim: To study the prevalence of Gilbert Syndrome (GS) and its genetic determinants in Chile. Material and Methods: Three different studies were conducted. The prevalence of GS in Chile was assessed in 991 subjects with normal liver tests (ALT and GGT) from the 2nd National Health Survey. We defined GS as a total bilirubin (TB) between 1.4-5mg/dL. The s...

  8. Diagnosis and treatment difficulties in 18-year-old male patient with hereditary hemochromatosis, chronic hepatitis B, Gilbert syndrome and ulcerative colitis.

    Science.gov (United States)

    Sikorska, Katarzyna; Liberek, Anna; Romanowski, Tomasz; Szlagatys-Sidorkiewicz, Agnieszka; Landowski, Piotr; Bielawski, Krzysztof P

    2011-01-01

    Among possible causes of chronic hepatitis in adolescents most common are infections, autoimmune disorders and metabolic diseases. Thus, diagnostic procedures should be multidirectional. This study reports diagnosis and treatment difficulties in an 18-year-old male patient with hereditary hemochromatosis (HH), ulcerative colitis (UC), chronic hepatitis B (CHB) and Gilbert syndrome. The presented case illustrates problems in diagnostics related to the presence of numerous disease conditions in one patient. It should be taken into consideration that these diseases coexisting in one patient can mutually affect their symptoms creating specific diagnostic difficulties.

  9. Genotype of UGT1A1 and phenotype correlation between Crigler-Najjar syndrome type II and Gilbert syndrome.

    Science.gov (United States)

    Maruo, Yoshihiro; Nakahara, Sayuri; Yanagi, Takahide; Nomura, Akitaka; Mimura, Yu; Matsui, Katsuyuki; Sato, Hiroshi; Takeuchi, Yoshihiro

    2016-02-01

    Hereditary unconjugated hyperbilirubinemias, Crigler-Najjar syndrome type I, Crigler-Najjar syndrome type II (CN-2), and Gilbert syndrome (GS) all result from mutations of the bilirubin uridine 5'-diphosphate (UDP)-glucuronosyltransferase gene (UGT1A1). Often, to distinguish between CN-2 and GS is difficult because the borderline of the two syndromes is unclear. We analyzed the genotypes and phenotypes of 163 Japanese patients with CN-2 or GS. Japanese patients (99 males and 64 females) with unconjugated hyperbilirubinemia were analyzed. Their serum bilirubin concentrations varied from 1.2 to 22.2 mg/dL (20 to 379 μM). Genetic analysis of UGT1A1 was performed by PCR-amplified direct sequencing. Association between serum bilirubin concentrations and genotypes group (typical CN-2, intermediate group, and typical GS) was studied. Most patients had biallelic mutations of UGT1A1. Moreover, many of them (78.5%) had multiple mutations. The mutation in typical CN-2 was a homozygous double missense mutation of p.[G71R:Y486D]. In typical GS group, four prevalent genotypes were detected: homozygous UGT1A1*28, UGT1A1*6/UGT1A1*28, and homozygous UGT1A1*6, and UGT1A1*27/UGT1A1*28. In the intermediate group, three genotypes, p.[G71R:Y486D]/UGT1A1*7, p.[G71R:Y486D]/UGT1A1*6, and homozygous UGT1A1*7, were detected. Serum bilirubin concentrations of typical CN-2, intermediate group, and typical GS are respectively 12.9 ± 5.1, 5.2 ± 2.2, and 2.8 ± 1.1 mg/dL. Serum bilirubin concentration among the three groups is statistically different (P syndromes. Clinically, it is difficult to distinguish clearly between the two syndromes. © 2015 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

  10. The Start of Plate Tectonics in the Eoarchean: A Tribute to Gilbert N Hanson, Pioneer in Archean Geochemistry

    Science.gov (United States)

    Shirey, S. B.; Kamber, B. S.; Whitehouse, M. J.; Mueller, P. A.; Basu, A. R.

    2007-05-01

    The use of isotopic and trace element geochemistry and igneous petrology to understand the petrogenesis of Archean rocks was pioneered by Gilbert Hanson and Joseph Arth at SUNY Stony Brook in the 1970's. Extension of these approaches allows the onset of plate tectonics on Earth shortly after the end of the Hadean to be specified. Nb/Th and Th/U ratios of mafic-ultramafic rocks from the depleted upper mantle begin to change from 7 to 18.2 and 4.7 to 2.9 (respectively) at 3.6 Ga. This signals the appearance of subduction-altered slabs in general mantle circulation from subduction initiated at 3.8 Ga. Juvenile crustal rocks begin to show derivation from progressively depleted mantle with typical igneous ɛNd:ɛHf = 1:2 after 3.6 Ga. Cratons with stable mantle keels that have subduction imprints begin to appear at 3.5 Ga. These changes all suggest that extraction of continental crust by plate tectonic processes was progressively depleting the mantle from 3.6 Ga onwards. Neoarchean subduction appears largely analogous to present subduction except in being able to produce large cratons with thick mantle keels. The earliest Eoarchean juvenile rocks and Hadean zircons have compositions that reflect the integrated effects of separation of an early enriched reservoir and fractionation of perovskite from the Mars-size impact-derived magma ocean, rather than separation of voluminous continental crust or oceanic plate tectonics. Hadean zircons most likely were derived from a continent-absent, mafic to ultramafic protocrust that was multiply remelted between 4.4 and 4.0 Ga under wet conditions to produce evolved felsic rocks. If the protocrust was produced by global mantle overturn at ca 4.4 Ga, then the transition to plate tectonics resulted from radioactive decay-driven mantle heating. Otherwise, such protocrust would have been the typical product of mantle convection and the transition to plate tectonics resulted from cooling to the extent that large lithospheric plates

  11. Sir Gilbert Thomas Walker

    Indian Academy of Sciences (India)

    and Iceland as 'North Atlantic Oscillation' and similar oscillation in the northern. Pacific Ocean as 'North Pacific Oscillation'. These three oscillations of surface pressure playa fundamental role in the variability of the earth's climate. Walker noted a tendency of the Southern Oscillation to persist for at least one to two seasons ...

  12. Infestation pattern and parasitic castration of the crustacean Riggia paranensis (Crustacea: Cymothoidea on the fresh water fish Cyphocharax gilbert (Teleostei: Curimatidae

    Directory of Open Access Journals (Sweden)

    Juliana de Souza Azevedo

    Full Text Available Cyphocharax gilbert infested by Riggia paranensis shows parasitic castration. The prevalence of parasitism in C. gilbert varied among different environments, being higher in the middle rio Itabapoana. Fish were collected monthly using two cast nets (thrown 30 times during the day and gillnets kept in the river during 12 hour, from sunset to sunrise, between September 1997 and August 2000. Infestation pattern was investigated on 1358 specimens. Most of them were infested (57.9%, with one or two parasites; the majority (62.9% was collected during the rainy season (spring-summer. The parasite did not show preference for sex or size of hosts. A total of 91.5% of the 511 examined parasites had a body size that represented 10.1% to 20% of host standard length. The reproductive condition of 311 specimens of R. paranensis was analyzed checking the presence of oocytes in the ovarian and eggs or embryos in the marsupium. Nearly 73% of them were at reproductive phase, and had a body size that represented 5.1% to 20% of host standard length. The size of the immature parasites varied from 0.1% to 5% of the host size. The results suggest that R. paranensis may adopt a fast growth rate strategy and increase the investment in reproduction when they occupy most of the host's pericardial space.

  13. EL «DE MODO ADDISCENDI» (C.1263 DE GILBERT DE TOURNAI O.F.M., UN PUENTE ENTRE LA TRADICIÓN Y EL RENACIMIENTO

    Directory of Open Access Journals (Sweden)

    Javier Vergara

    2013-01-01

    Full Text Available El renacimiento cultural que se produce en los siglos XII y XIII dio origen a una producción literaria abundante que tuvo en la educación uno de sus ejes más significativos. Un ejemplo patente es el De modo addiscendi, obra publicada hacia 1263, por el franciscano Gilbert de Tournai, en la que se resume una buena parte de la pedagogía escolástica. La obra, no traducida a lengua viva y apenas estudiada por la historiografía pedagógica, tiene por objeto mostrar cómo el maestro y el discípulo debían alcanzar la sabiduría. Un intento loable cuyo estudio y conocimiento ha exigido traducir y comparar diferentes manuscritos latinos, a la vez que analizar los principales estudios realizados sobre el tema. El resultado confirma a Gilbert de Tournai como uno de los pedagogos más importantes del siglo XIII y un puente de unión entre la tradición y la educación renacentista, que la historiografía pedagógica debe reivindicar y actualizar, siendo este trabajo una mínima aportación a su causa.

  14. Frequency of depression, according to Beck questionnaire, on medical students from Manizales city (Colombia), 2014: cross sectional study

    OpenAIRE

    Alonso Polo, José David; Castaño Castrillón, José Jaime M.Sc.; Cerón Rosero, Yesica Estefanía; Laura Melisa, Dávila Menjura; De la Rosa, Adonilson Julio psiquiatra.; De la Rosa Marrugo, Paola Edith; Montoya Arango, Verónica; Olave Peña, Cristian Manuel

    2015-01-01

    Objetivo: Establecer la frecuencia de depresión en estudiantes de los programas de medicina de la Universidad de Manizales y de la Universidad de Caldas (Manizales, Colombia). Materiales y métodos: Estudio de corte transversal analítico, en estudiantes de pregrado de medicina de 1° a 10° semestre de la universidad de Manizales y la universidad de Caldas. Se indagó sobre variables demográficas y otros antecedentes, se utilizó el inventario de depresión de Beck, al igual que el cues...

  15. Factorial Structure of Depressive Symptoms in Anglophone Caribbean University Students: Psychometric Properties of the Beck Depression Inventory-II

    OpenAIRE

    Michael H. Campbell; Jonathan W. Roberti; Donna-Maria Maynard; Maisha K. Emmanuel

    2009-01-01

    Este estudio buscó establecer propiedades psicométricas del Inventario de Depresión de Beck-Segunda Edición (BDI-II) con estudiantes de una universidad del Caribe (n=400, 76% mujeres, edad media=25.2). Además, administramos la Escala de Elasticidad de Ego-89, La Escala de Tensión Percibida, La Escala de Ansiedad Estado-Rasgo (Versión de Rasgo) y La Escala de Depresión de Zung. El análisis factorial confirmativo comparó la estructura observada con las estructuras oblicuas propuestas en los mod...

  16. Public-academic partnerships: the Beck Initiative: a partnership to implement cognitive therapy in a community behavioral health system.

    Science.gov (United States)

    Stirman, Shannon Wiltsey; Buchhofer, Regina; McLaulin, J Bryce; Evans, Arthur C; Beck, Aaron T

    2009-10-01

    The Beck Initiative is a partnership between researchers and clinicians at a large university and an urban behavioral health managed care system. Both partners share a commitment to ensuring that consumers in the community have access to competently delivered, individualized, evidence-based mental health care and that the providers who serve them have the support they need to deliver high-quality evidence-based treatments. Central features of the program are individualized training and consultation in cognitive therapy for each provider agency and policies to promote the sustainability of the initiative and its continuing evolution to meet the needs of providers and consumers.

  17. [Implementation of a Laparoscopic Simulation Training in Undergraduate Medical Education - The Lübeck Toolbox-Curriculum].

    Science.gov (United States)

    Laubert, Tilman; Thomaschewski, Michael; Auerswald, Paul; Zimmermann, Markus; Brüheim, Linda; Keck, Tobias; Benecke, Claudia

    2017-05-15

    Background Simulation-based training has become increasingly relevant in minimally invasive surgery (MIS). It is unclear whether or not the established Lübeck Toolbox (LTB) Curriculum for the acquisition of basic MIS skills can be implemented to supplement standard undergraduate education in surgery and how it would be accepted. Materials und Methods Since 04/2015, students at the medical school of the University of Lübeck have had the option to complete the highly standardized and validated LTB Curriculum. It consists of six subsequent tasks with pre-defined learning goals. Video tutorials allow for a self-educating approach. The individual training progress is documented continuously as scheduled by the curriculum. The program was evaluated in a standardized manner using an established online platform for the evaluation of university courses at the University of Lübeck. Results Between 04/2015 and 07/2016, 63 students completed the LTB Curriculum. The general interest in a surgical specialty rose from an average of 1.61 (SD 0.78) before to 1.12 after the curriculum. The numbers of required repetitions for the training tasks 1 - 6 were median 24 (6 - 79), 23 (5 - 61), 7 (5 - 33), 15 (5 - 59), 16 (5 - 50), and 18 (7 - 48), respectively. None of the 63 students terminated the curriculum prematurely. On average, 4.35 (SD 1.58) hours per week were spent training with an overall duration of 4.1 (SD 1.2) weeks required to go through the LTB Curriculum. Evaluation results showed an overall rating of 1.0 (SD 0.17). The average learning progress, didactics and structure of the curriculum were rated as 1.0 (SD 0.24), 1.14 (SD 0.36), and 1.0 (SD 0.24), respectively. The relevance for the following study years and the future professional activity was reported to be 1.2 (SD 0.45) on average. Conclusion As an addition to the regular undergraduate program, the Lübeck Toolbox Curriculum was well accepted by many students. Evaluation showed

  18. Crowdsourcing na música - análise de caso do projeto song reader do cantor Beck Hansen │ Crowdsourcing in music - Case study of singer Beck Hansen's Song Reader project

    Directory of Open Access Journals (Sweden)

    Cristiano Max Pereira Pinheiro

    2014-05-01

    ABSTRACT This study aims to analyze how the Song Reader project of singer Beck Hansen used Crowdsourcing and how participants felt to be part of it. Interviews were conducted with YouTube users having posted on their site their versions of the songs in the project; two reviews of news sites were also analyzed. The focus of the analysis was to identify the profiles of the people who participated in the project, to understand what types of participation/interaction were generated with the project, to analyze the motivations that led people to participate in the project and finally to understand how these people evaluated the experience. At the end of the study, we can make it clear that in the music business, generating experience with the public can be fundamental. After all, people crave and feel something when listening to the songs, and that defines the experience: how to make people feel and become involved. For this, one must know the audience, and it was just what the Song Reader project demonstrated in this work, caring and generating impact on its stakeholders: amateurs, artists and media. Keywords: Crowdsourcing; Music; Song Reader; Beck Hansen.

  19. "If you thought this story sour, sweeten it with your own telling" - a feminist poetics of rewriting in Susan Price's Ghost dance

    Directory of Open Access Journals (Sweden)

    Sanna Lehtonen

    2010-01-01

    Full Text Available The attempts to challenge conventional gendered discourses in children's fantasy have often resulted in feminist rewritings of earlier stories. Ghost dance (1994 by the English author Susan Price is a novel that reflects a specific feminist poetics of rewriting: metafictional passages highlight the constructedness of the narrative and at the end readers are invited to tell their own versions of the story. Moreover, the rewriting freely combines and recontextualises elements from different source texts and reformulates them to create a narrative that challenges conventional discourses of gender. While this poetics has an appeal from a feminist perspective, the play with cross-cultural intertexts and gender becomes more complex when the novel is examined in a postcolonialist framework in relation to ethnicity and the issue of cultural appropriation. Ghost dance is situated in a setting that has a real-world equivalent (Russia, involves characters that are identified with names of real-world ethnic groups (Lapps (Sámi, Russian, and mixes elements from Russian wonder tales, Nordic mythology and an Ojibwe legend. The novel does not aim at historical accuracy in its representations nor is it a direct retelling of any of the pre-texts but combines motifs, themes, names, characters and settings freely from each source. In this textual melting pot, the protagonist Shingebiss is, on one level, a revision of the witch Baba Yaga, but also described as a Lappish shaman with an Ojibwe name. To rewrite gendered discourses, certain elements from the pretexts are chosen and others left out – the question is, then, what effects does this recontextualisation have on the representation of ethnicity? Or, are the feminist rewriting strategies actually a form of cultural appropriation?

  20. A narrative review of the Beck Depression Inventory (BDI) and implications for its use in an alcohol-dependent population.

    Science.gov (United States)

    McPherson, A; Martin, C R

    2010-02-01

    The findings from the present study reveal that the Beck Depression Inventory (BDI) is a reliable and valid instrument for measuring depression in a variety of populations. This realization should enable nurses and other health professionals to utilize the tool with added confidence and assurance. * The main finding was that the BDI would probably be a reliable and valid screening tool in an alcohol-dependent population. This conclusion appears to echo the relationship that alcohol consumption generally has with depression. This finding is important to those practitioners using the BDI in this population in that it provides further evidence to enhance their practical experience. Abstract A psychometric evaluation of the Beck Depression Inventory (BDI) was carried out on contemporary studies to ascertain its suitability for use in an alcohol-dependent population. Three criteria were used for this: factor analysis, test-retest reliability and internal consistency reliability. Factor analysis revealed that its structure is consistent with either two or three factor models, depending on the population. Test-retest results concluded that the correlation coefficient remained above the recommended threshold and internal consistency reliability highlighted alpha coefficient results consistently above suggested scores, leading to the conclusion that the BDI is probably an effective screening tool in an alcohol-dependent population.

  1. Specificity and sensitivity of the Beck Hopelessness Scale for suicidal ideation among adolescents entering early intervention service.

    Science.gov (United States)

    Granö, Niklas; Oksanen, Jorma; Kallionpää, Santeri; Roine, Mikko

    2017-01-01

    Previous studies have shown an association between hopelessness and suicidal behaviour in clinical populations. The aim of the study was to investigate sensitivity, specificity, and predictive validity of the Beck Hopelessness Scale (BHS) for suicidal ideation in adolescents who show early risk signs on the psychiatric disorder continuum. Three-hundred and two help-seeking adolescents (mean age = 15.5 years) who were entering an early intervention team at Helsinki University Central Hospital, Finland, completed questionnaires of BHS and suicidal ideation, derived from Beck Depression Inventory (BDI-II). Results suggest that a BHS cut-off score ≥8 (sensitivity = 0.70, specificity = 0.76) or cut-off score ≥9 (sensitivity = 0.63, specificity = 0.80) may be useful to detect suicidal ideation with BHS in help-seeking adolescents population. Results remain mainly the same in a separate analysis with adolescents at risk for psychosis. The results support previous cut-off points for BHS in identification of suicidal ideation. The results suggest also that lower cut-off scores may be useful in sense of sensitivity, especially in clinical settings.

  2. Local Constructions of Vulnerability and Resilience in the Context of Climate Change. A Comparison of Lübeck and Rostock

    Directory of Open Access Journals (Sweden)

    Gabriela B. Christmann

    2014-02-01

    Full Text Available Climate change is globally defined as a “reality”. This does not mean however that the way in which it is understood is the same all over the world. Rather, perceptions may differ at different places and times, even if physical and geographical conditions are similar. For the time being, this phenomenon has not been dealt with on a theoretical-conceptual level. The article will address this desiderate. Based on the approaches of social constructivism as well as actor-network theory, a theoretical concept will be suggested as a heuristic model for empirical analysis. By the examples of Lübeck and Rostock, two cities on Germany’s Baltic coast, it will be shown that climate change related perceptions of vulnerability and resilience may build on physical-material aspects but that they are above all considerably interwoven with specific cultural and social patterns of interpretation. In the framework of the local discourse in Lübeck, it is the strong Hanseatic tradition which consumes the climate change issue, whereas in Rostock it is the problems and historical breaks of a transformation society which shape the way of viewing climate change.

  3. Using rf voltage induced ferromagnetic resonance to study the spin-wave density of states and the Gilbert damping in perpendicularly magnetized disks

    Science.gov (United States)

    Devolder, Thibaut

    2017-09-01

    We study how the shape of the spin-wave resonance lines in rf voltage induced FMR can be used to extract the spin-wave density of states and the Gilbert damping within the precessing layer in nanoscale magnetic tunnel junctions that possess perpendicular magnetic anisotropy. We work with a field applied along the easy axis to preserve the cylindrical symmetry of the uniaxial perpendicularly magnetized systems. We first describe the experimental setup to study the susceptibility contributions of the spin waves in the field-frequency space. We then identify experimentally the maximum device size above which the spin waves confined in the free layer can no longer be studied in isolation as the linewidths of their discrete responses make them overlap into a continuous density of states. The rf voltage induced signal is the sum of two voltages that have comparable magnitudes: a first voltage that originates from the linear transverse susceptibility and rectification by magnetoresistance and a second voltage that arises from the nonlinear longitudinal susceptibility and the resultant time-averaged change of the exact micromagnetic configuration of the precessing layer. The transverse and longitudinal susceptibility signals have different dc bias dependencies such that they can be separated by measuring how the device rectifies the rf voltage at different dc bias voltages. The transverse and longitudinal susceptibility signals have different line shapes; their joint studies in both fixed field-variable frequency, or fixed frequency-variable field configurations can yield the Gilbert damping of the free layer of the device with a degree of confidence that compares well with standard ferromagnetic resonance. Our method is illustrated on FeCoB-based free layers in which the individual spin waves can be sufficiently resolved only for disk diameters below 200 nm. The resonance line shapes on devices with 90-nm diameters are consistent with a Gilbert damping of 0.011 . A single

  4. Idufirma Silicon Valleyta / Susan Adams

    Index Scriptorium Estoniae

    Adams, Susan

    2014-01-01

    Tarkvarafirma Apprenda toodab teenindusplatvormi tarkvara, mis võimaldab klientidel luua ja hoida käigus uusi mobiilseid ja pilvetehnoloogiapõhiseid rakendusi. Oma töötajatele pakub odavaid elamispindu ja madalaid makse

  5. Escala de Desesperanza BHS (A. Beck, 1974: estudio de las propiedades psicométricas y baremización de la Adaptación Argentina Beck Hopelessness Scale BHS (A. Beck, 1974: psychometric study and standardization of Argentinian Adaptation

    Directory of Open Access Journals (Sweden)

    Isabel María Mikulic

    2009-12-01

    Full Text Available El presente estudio se propone presentar los resultados obtenidos en la adaptación, validación y estandarización de la Escala de Desesperanza-BHS (A. Beck, 1974; Adaptación Argentina: I.M. Mikulic, 1998. La adaptación se realizó mediante la técnica de "back translation" y en el proceso de validación participaron 377 participantes de Capital Federal y Gran Buenos Aires, entre las edades de 18 y 50 años (M: 28; SD: 7,9. Se analizó la consistencia interna de la escala, así como su validez concurrente, predictiva, diferencial y factorial. El coeficiente alpha de confiabilidad del instrumento fue aceptable. Los coeficientes de correlación de la BHS con la adaptación argentina del Inventario de Depresión de Beck (BDI-II demuestran ser significativos, sobre todo con aquellos ítems del BDI que evalúan pesimismo. El análisis de regresión realizado advierte que el 16% de la variabilidad en los puntajes de la prueba BDI pueden ser atribuidos a la variable desesperanza. El análisis factorial realizado con la técnica de Componentes Principales y rotación Varimax identificó tres factores que explican el 54,8 % de la varianza. Al considerar la validez diferencial de la BHS, se evidencia que no existe asociación entre desesperanza y género, y que las correlaciones con nivel educativo y edad son muy bajas. Con el fin de disponer de normas locales, se han elaborado las tablas de equivalencia para Capital Federal y Gran Buenos Aires. Los resultados obtenidos en el presente estudio permiten concluir que la Escala BHS adaptada evalúa un constructo psicológicamente significativo en nuestro medio y puede ser usada con propósitos de "screening" en diversos contextos.Present study aims to show adaptation process, validation procedures and standardization norms for Beck Hopelessness Scale BHS (A. Beck, 1974; Argentinian Version: I.M. Mikulic, 1998. Argentinian Adaptation underwent a "back translation" process and it has been validated in an

  6. Two linked polymorphic mutations (A(TA)7TAA and T-3279G) of UGT1A1 as the principal cause of Gilbert syndrome.

    Science.gov (United States)

    Maruo, Yoshihiro; D'Addario, Carlos; Mori, Asami; Iwai, Masaru; Takahashi, Hiroko; Sato, Hiroshi; Takeuchi, Yoshihiro

    2004-11-01

    Gilbert syndrome is a mild hereditary unconjugated hyperbilirubinemia caused by mutations in the bilirubin UDP-glucuronosyltransferase gene (UGT1A1). The mutation, A(TA)7TAA, is thought to be the sole cause of the syndrome in Caucasians, but an enhancer polymorphism (T-3279G) that lowers transcriptional activity has recently been reported. We have tested the linkage of the two mutations in 11 Caucasians and 12 Japanese patients who were homozygous for A(TA)7TAA. All 23 patients were also homozygous for T-3279G, indicating that T-3279G and A(TA)7TAA were linked. The decrease in transcription caused by both mutations together may be essential to the syndrome.

  7. Beck's cognitive theory and the response style theory of depression in adolescents with and without mild to borderline intellectual disability.

    Science.gov (United States)

    Weeland, Martine M; Nijhof, Karin S; Otten, R; Vermaes, Ignace P R; Buitelaar, Jan K

    2017-10-01

    This study tests the validity of Beck's cognitive theory and Nolen-Hoeksema's response style theory of depression in adolescents with and without MBID. The relationship between negative cognitive errors (Beck), response styles (Nolen-Hoeksema) and depressive symptoms was examined in 135 adolescents using linear regression. The cognitive error 'underestimation of the ability to cope' was more prevalent among adolescents with MBID than among adolescents with average intelligence. This was the only negative cognitive error that predicted depressive symptoms. There were no differences between groups in the prevalence of the three response styles. In line with the theory, ruminating was positively and problem-solving was negatively related to depressive symptoms. Distractive response styles were not related to depressive symptoms. The relationship between response styles, cognitive errors and depressive symptoms were similar for both groups. The main premises of both theories of depression are equally applicable to adolescents with and without MBID. The cognitive error 'Underestimation of the ability to cope' poses a specific risk factor for developing a depression for adolescents with MBID and requires special attention in treatment and prevention of depression. WHAT THIS PAPER ADDS?: Despite the high prevalence of depression among adolescents with MBID, little is known about the etiology and cognitive processes that play a role in the development of depression in this group. The current paper fills this gap in research by examining the core tenets of two important theories on the etiology of depression (Beck's cognitive theory and Nolen-Hoeksema's response style theory) in a clinical sample of adolescents with and without MBID. This paper demonstrated that the theories are equally applicable to adolescents with MBID, as to adolescents with average intellectual ability. However, the cognitive bias 'underestimation of the ability to cope' was the only cognitive error

  8. Psychometric properties of the Beck Depression Inventory II (BDI-II) among community-dwelling older adults.

    Science.gov (United States)

    Segal, Daniel L; Coolidge, Frederick L; Cahill, Brian S; O'Riley, Alisa A

    2008-01-01

    The psychometric properties of the Beck Depression Inventory-II (BDI-II) as a self-administered screening tool for depressive symptoms were examined in a sample of community-dwelling older and younger adults. Participants completed the BDI-II, the Center for Epidemiologic Studies Depression Scale, the Coolidge Axis II Inventory, the Perceived Stress Scale, and the Short Psychological Well-Being Scale. Internal reliability of the BDI-II was found to be good among older and younger adults. The average BDI-II depression score did not differ between younger and older adults. Solid evidence for convergent and discriminant validity was demonstrated by correlations between the BDI-II with the other measures. The BDI-II appears to have strong psychometric support as a screening measure for depression among older adults in the general population. Implications for using the BDI-II as an assessment instrument in behaviorally based psychotherapy are discussed.

  9. O velho mundo novo do trabalho: concepção e abordagem em Ulrick Beck e Zygmunt Bauman

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Chaves

    2006-01-01

    Full Text Available Este artigo tem por finalidade apresentar considerações delineadas por Beck e Bauman sobre o mundo do trabalho, problematizando as concepções e possibilidades apontadas por ambos. A hipótese de partida centra-se no argumento de que as constantes mudanças percebidas no mundo do trabalho, neste momento, ocorrem em decorrência de processos societais pretéritos e não propriamente em decorrência da vontade dos indivíduos. Entretanto, para se pensar a relação entre o mundo do trabalho e o indivíduo, na pós-modernidade, é imprescindível a leitura histórica dos aspectos sociais, psicológicos e fisiológicos do trabalho.

  10. Beck Depression Inventory II: evaluation of the psychometric properties and cut-off points in a Turkish adult population.

    Science.gov (United States)

    Kapci, Emine Gul; Uslu, R; Turkcapar, H; Karaoglan, A

    2008-01-01

    Numerous studies have been previously conducted to assess the Beck Depression Inventory-II's [BDI II; Beck et al., 1996] psychometric properties. However, none of these studies has examined whether the original cut-off scores were applicable to other cultures. Thus, in addition to evaluating its psychometric properties, we also determined the cut-off scores of the BDI II for the Turkish population. Data from nonclinical (n = 362) and clinical psychiatric outpatients diagnosed as depressive disorder according to DSM-IV criteria (n = 176) were gathered. Analyses for internal consistency and test-retest reliabilities and for convergent and discriminant validities were computed. Two confirmatory factor analyses, one derived from the present exploratory factor analyses and the other proposed in the original study were conducted for both groups. A receiver operating characteristics curve was utilized to determine the cut-off scores for the Turkish population revealing 0-12 for minimal, 13-18 for mild, 19-28 for moderate and 29-63 for severe depression. The internal consistency for the nonclinical and clinical groups were .90 and .89, respectively; test-retest stability was also high (r = .94). Convergent and discriminant validity results were satisfactory. Findings confirmed the present model for the clinical group and equally confirmed both models for the nonclinical group. Furthermore, the cut-off scores to classify minimal, mild, moderate, and severe depression were quite akin to the cut-off points previously suggested for the American population. Taken as a whole our findings revealed that BDI II has sound psychometric properties and comparable cut-off scores for the Turkish population. Depression and Anxiety, 2008. (c) 2007 Wiley-Liss, Inc.

  11. A inteligência do mundo : sobre a cognição de processos globais em Octavio Ianni e Ulrich Beck

    OpenAIRE

    Danilo Arnaut Saraiva

    2014-01-01

    Resumo: Esta dissertação materializa um conjunto de reflexões a respeito dos trabalhos de Octavio Ianni e Ulrich Beck sobre os processos de globalização. Trata-se de uma sociologia dessas sociologias que objetiva investigar a própria cognoscibilidade desses processos através dos elementos que orientam a criação sociológica desses autores. Abstract: This dissertation is based on a set of analyses of the works of Octavio Ianni, and Ulrich Beck on the processes of globalization. It constitut...

  12. Validity of the Hospital Anxiety and Depression Scale and the Beck Depression Inventory for use in end-stage renal disease patients

    NARCIS (Netherlands)

    Loosman, W.L.; Siegert, C.E.H.; Korzec, A.; Honig, A.

    2010-01-01

    Objective. To validate the Hospital Anxiety and Depression Scale (HADS) and the Beck Depression Inventory (BDI) for use in patients with end-stage renal disease (ESRD) and to compare the outcome of both screening measures with each other. Design. Cross-sectional and between-subjects design. The

  13. [Antjekathrin Grassmann. Zu den wirtschaftlichen und persönlichen Beziehungen Lübecks ins Baltikum im Lichte einer unbeachteten mittelalterlichen Quellegruppe]/ Dennis Hortmuth

    Index Scriptorium Estoniae

    Hormuth, Dennis

    2012-01-01

    Arvustus: Antjekathrin Grassmann. Zu den wirtschaftlichen und persönlichen Beziehungen Lübecks ins Baltikum im Lichte einer unbeachteten mittelalterlichen Quellegruppe. In: Leder ist Brot. Beiträge zur norddeutschen Landes- und Archivgeseten. Schwerin 2011. S. 125-135

  14. Adaptation and Latent Structure of the Swahili Version of Beck Depression Inventory-II in a Low Literacy Population in the Context of HIV

    NARCIS (Netherlands)

    Abubakar, A.; Kalu, Raphael Birya; Katana, Khamis; Kabunda, Beatrice; Hassan, Amin S.; Newton, Charles R.; Van de Vijver, Fons

    2016-01-01

    Objective We set out to adapt the Beck Depression Inventory (BDI)-II in Kenya and examine its factorial structure. Methods In the first phase we carried out in-depth interviews involving 29 adult members of the community to elicit their understanding of depression and identify aspects of the BDI-II

  15. Is the beck anxiety inventory a good tool to assess the severity of anxiety? A primary care study in The Netherlands study of depression and anxiety (NESDA)

    NARCIS (Netherlands)

    Muntingh, Anna D. T.; van der Feltz-Cornelis, Christina M.; van Marwijk, Harm W. J.; Spinhoven, Philip; Penninx, Brenda W. J. H.; van Balkom, Anton J. L. M.

    2011-01-01

    Background: Appropriate management of anxiety disorders in primary care requires clinical assessment and monitoring of the severity of the anxiety. This study focuses on the Beck Anxiety Inventory (BAI) as a severity indicator for anxiety in primary care patients with different anxiety disorders

  16. Is the beck anxiety inventory a good tool to assess the severity of anxiety? A primary care study in the Netherlands Study of Depression and Anxiety (NESDA)

    NARCIS (Netherlands)

    Muntingh, A.D.T.; van der Feltz-Cornelis, C.M.; van Marwijk, H.W.J.; Spinhoven, P.; Penninx, B.W.J.H.; van Balkom, A.J.L.M.

    2011-01-01

    Background: Appropriate management of anxiety disorders in primary care requires clinical assessment and monitoring of the severity of the anxiety. This study focuses on the Beck Anxiety Inventory (BAI) as a severity indicator for anxiety in primary care patients with different anxiety disorders

  17. Confirmatory factor analysis of the Beck Depression Inventory-II and the association with cardiac morbidity and mortality after coronary revascularization

    NARCIS (Netherlands)

    Tully, Phillip J.; Winefield, Helen R.; Baker, Robert A.; Turnbull, Deborah A.; de Jonge, Peter

    This study examined the Beck Depression Inventory-II (BDI-II) with Confirmatory Factor Analysis and followed up cardiac morbidity and mortality for a median of 4.9 years among 226 coronary artery bypass graft patients. Cardiac morbidity and mortality events (n = 65, 28.8%) were associated with

  18. Distribution and population structure of the fish Cyphocharax gilbert (Characiformes: Curimatidae in the Lower Paraíba do Sul River, Brazil

    Directory of Open Access Journals (Sweden)

    M.S Menezes

    2007-12-01

    Full Text Available The distribution and population structure of Cyphocharax gilbert in four areas of the lower Paraíba do Sul River and its major tributaries (22ºS, 43ºW were analyzed between March 1989 and February 1990. The species was common throughout the area, preferring major rivers with high turbidity and sand-mud substrates and range of length and size of specimens found varied depending on the particular characteristics of the site. A predominance of females was found in only area. Nevertheless, in all areas the bimonthly analysis showed preponderance of one of the sexes in periods before or after spawning. Males prevailed in shorter length classes and females in longer ones. There was a prevalence of young in one area that probably was used as a growth and feeding zone. Rev. Biol. Trop. 55 (3-4: 1015-1023. Epub 2007 December, 28.Se analizó aspectos de la distribución y estructura poblacional de Cyphocharax gilbert en cuatro diferentes áreas del cause bajo del Rio Paraíba do Sul y sus principales afluentes (22ºS, 43ºW, entre marzo de 1989 y febrero de 1990. La especie fue común en toda su extención, ocupando preferentemente los ríos grandes con aguas turbias y substrato de arena-lodo. Los ámbitos de longitud y frecuencia de tamaños variaron con el lugar. Solo en una de las áreas hubo mayor proporción de hembras. Sin embargo, el análisis bimensual mostró una preponderancia de uno de los sexos en períodos antes y después del período reprodutivo en todas las áreas. Los machos prevalecen en los tamaños inferiores y las hembras en los superiores. Huvo una prevalencia de jóvenes en un área usada probablemente como una región para alimentación y crecimiento.

  19. Electronic structure engineering of ZnO with the modified Becke-Johnson exchange versus the classical correlation potential approaches

    KAUST Repository

    Ul Haq, Bakhtiar

    2013-12-01

    In this study, we report investigations of structural and electronic properties of ZnO in wurtzite (WZ), rock salt (RS) and zinc-blende (ZB) phases. Calculations have been done with full-potential linearized augmented plane wave plus local orbital method developed within the frame work of Density Functional Theory (DFT). For structural properties investigations, Perdew and Wang proposed local density approximations (LDA) and Perdew et al. proposed generalized gradient approximations (GGA) have been applied. Where for electronic properties in addition to these, Tran-Blaha modified Becke-Johnson (mBJ) potential has been used. Our computed band gap values of ZnO in WZ and ZB phases with mBJ potential are significantly improved compared to those with LDA and GGA; however, in RS phase, energy gap is significantly overestimated compared to experimental measurements. The Zn-d band was found to be more narrower with mBJ potential than that of LDA and GGA. On the other hand, our evaluated crystal field splitting energy values overestimate the experimental values. © 2013 Taylor and Francis.

  20. Validating the Beck Depression Inventory-II in Indonesia’s general population and coronary heart disease patients

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    Henndy Ginting

    2013-01-01

    Full Text Available Este estudio evalúa la validez y determina los puntos de corte del Inventario de Depresión de Beck -II (BDI-II en Indonesia. La versión indonesia del BDI-II (BDI-II Indo se administró a 720 personas sanas de la población general, a 215 pacientes con Enfermedad Coronaria (EC y a 102 pacientes con depresión. El análisis factorial confirmatorio mostró similitud factorial de las tres muestras. Las correlaciones entre el Indo BDI-II y otras medidas de auto-percepción relacionadas con la depresión fueron significativas, mostrando la validez de constructo del Indo BDI-II. Además, la diferencia de puntuación del Indo BDI-II entre los participantes deprimidos y no deprimidos fue altamente significativa. La consistencia interna y la fiabilidad re- test fueron suficientemente altas. La curva ROC (receiver operating characteristic indicó que el punto de corte de la BDI-II para el nivel de gravedad leve de depresión la población de Indonesia es igual a 17. En conclusión, el Indo BDI-II es una medida válida de depresión, tanto para la población general indonesia como en pacientes con EC.

  1. Prediction of Beck Depression Inventory (BDI-II) Score Using Acoustic Measurements in a Sample of Iium Engineering Students

    Science.gov (United States)

    Fikri Zanil, Muhamad; Nur Wahidah Nik Hashim, Nik; Azam, Huda

    2017-11-01

    Psychiatrist currently relies on questionnaires and interviews for psychological assessment. These conservative methods often miss true positives and might lead to death, especially in cases where a patient might be experiencing suicidal predisposition but was only diagnosed as major depressive disorder (MDD). With modern technology, an assessment tool might aid psychiatrist with a more accurate diagnosis and thus hope to reduce casualty. This project will explore on the relationship between speech features of spoken audio signal (reading) in Bahasa Malaysia with the Beck Depression Inventory scores. The speech features used in this project were Power Spectral Density (PSD), Mel-frequency Ceptral Coefficients (MFCC), Transition Parameter, formant and pitch. According to analysis, the optimum combination of speech features to predict BDI-II scores include PSD, MFCC and Transition Parameters. The linear regression approach with sequential forward/backward method was used to predict the BDI-II scores using reading speech. The result showed 0.4096 mean absolute error (MAE) for female reading speech. For male, the BDI-II scores successfully predicted 100% less than 1 scores difference with MAE of 0.098437. A prediction system called Depression Severity Evaluator (DSE) was developed. The DSE managed to predict one out of five subjects. Although the prediction rate was low, the system precisely predict the score within the maximum difference of 4.93 for each person. This demonstrates that the scores are not random numbers.

  2. Optical response of mixed molybdenum dichalcogenides for solar cell applications using the modified Becke-Johnson potential

    Energy Technology Data Exchange (ETDEWEB)

    Ahuja, Ushma [Sardar Patel College of Engineering, Mumbai (India). Dept. of Electrical Engineering; Joshi, Ritu; Venugopalan, K. [M.L. Sukhadia Univ., Udaipur (India). Dept. of Physics; Kothari, D.C. [Mumbai Univ. (India). National Center for Nanosciences and Nanotechnology; Tiwari, Harpal [Malaviya National Institute of Technology, Jaipur (India). Dept. of Electrical Engineering

    2016-07-01

    Energy bands and density of states (DOS) of mixed molybdenum dichalcogenides like MoS{sub 2}, MoSeS, MoSe{sub 2}, MoTe{sub 2}, MoTeS, and MoTe{sub 0.5}S{sub 1.5} are reported for the first time using the Tran-Blaha modified Becke-Johnson potential within full potential-linearised augmented plane wave technique. From the partial DOS, a strong hybridisation between the Mo-d and chalcogen-p states is observed below the Fermi energy E{sub F}. In addition, the dielectric constants, absorption coefficients, and refractivity spectra of these compounds have also been deduced. The integrated absorption coefficients derived from the frequency-dependent absorption spectra within the energy range of 0-4.5 eV show a possibility of using molybdenum dichalcogenides, particularly MoTe{sub 0.5}S{sub 1.5}, in solar cell applications. Birefringence and degree of anisotropy are also discussed using the data on refractivity and imaginary components of the dielectric constant.

  3. Depressive Symptoms in Patients With Dry Eye Disease: A Case-Control Study Using the Beck Depression Inventory.

    Science.gov (United States)

    Hallak, Joelle A; Tibrewal, Sapna; Jain, Sandeep

    2015-12-01

    To measure depressive symptoms in patients with dry eye disease (DED) and controls using the Beck Depression Inventory (BDI) and to determine the association between depressive and DED symptoms. Fifty-three patients with DED and 41 controls were recruited to the study. DED symptoms were assessed using the Symptom Burden Tool and Ocular Surface Disease Index tool. Depressive symptoms were assessed using the BDI. Regression diagnostics were performed to detect outliers. Linear statistical models and polynomial regression were used to determine the relationship between depressive symptoms and DED symptoms. An independent t test was performed to determine differences in BDI scores between cases and controls. Scatter plots were generated and linear regression was used to estimate the association between scores. Logistic regression was used for the DED dichotomous outcome and depression status as exposure. Regression models revealed that the association is linear more than quadratic or cubic. After adjusting for age, sex, race, and psychiatric medication, the regression coefficient between DED symptoms and depressive symptoms among DED cases was 1.22 (95% confidence interval, 0.27-2.18). DED symptom scores and depression scores were statistically significantly different between DED cases and controls. Adjusted logistic regression revealed an odds ratio of 2.79 (95% confidence interval, 0.96-8.12). This study provides further evidence regarding the association between DED and depression and their symptoms. Prospective studies are needed to understand the mechanisms underlying the association between symptoms of depression and symptoms of DED.

  4. Diagnosing Depression in Chronic Pain Patients: DSM-IV Major Depressive Disorder vs. Beck Depression Inventory (BDI).

    Science.gov (United States)

    Knaster, Peter; Estlander, Ann-Mari; Karlsson, Hasse; Kaprio, Jaakko; Kalso, Eija

    2016-01-01

    Diagnosing depression in chronic pain is challenging due to overlapping somatic symptoms. In questionnaires, such as the Beck Depression Inventory (BDI), responses may be influenced more by pain than by the severity of depression. In addition, previous studies have suggested that symptoms of negative self-image, a key element in depression, are uncommon in chronic pain-related depression. The object of this study is to assess the relationship of the somatic and cognitive-emotional items of BDI with the diagnosis of depression, pain intensity, and disability. One hundred consecutive chronic pain patients completed the Structured Clinical Interview for DSM Disorders (SCID) for the diagnosis of major depressive disorder (MDD) according to DSM-IV. Two subscales of BDI (negative view of self and somatic-physical function) were created according to the factor model presented by Morley. In the regression analysis, the somatic-physical function factor associated with MDD, while the negative view of self factor did not. Patients with MDD had higher scores in several of the BDI items when analysed separately. Insomnia and weight loss were not dependent on the depression diagnosis. The relatively small sample size and the selected patient sample limit the generalisability of the results. Somatic symptoms of depression are also common in chronic pain and should not be excluded when diagnosing depression in pain patients. Regardless of the assessment method, diagnosing depression in chronic pain remains a challenge and requires careful interpretation of symptoms.

  5. Utility of the Beck Depression Inventory to Screen for and Track Depression in Injection Drug Users Seeking Hepatitis C Treatment

    Science.gov (United States)

    Holtzheimer, Paul E.; Veitengruber, Jason; Wang, Chia C.; Krows, Meighan; Thiede, Hanne; Wald, Anna; Roy-Byrne, Peter

    2010-01-01

    Objective Treating acute HCV in injection drug users (IDUs) is complicated by a high prevalence of psychiatric comorbidities that may lead to increased risk for depressive complications of interferon treatment. Effective screening strategies are needed to help non-psychiatric clinicians identify depressive disorders. Methods Thirty IDUs with acute HCV completed the Beck Depression Inventory (BDI), underwent a psychiatric examination, and were randomized to 24 weeks of pegylated interferon treatment (IFA) or observation (OBS). Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) of the BDI for diagnosing depression (with a cutoff >10) were calculated. The psychiatrist’s diagnosis was used as the gold standard. Depression severity was assessed over time with the BDI. Results Forty-seven percent of individuals met criteria for a depressive disorder. Sensitivity (91%) and NPV (92%) were high for the BDI; specificity (58%) and PPV (56%) were low. BDI worsened in 2 patients completing the study (one IFA, one OBS); two IFA patients were discontinued for possible depression-related complications. At baseline, subject-rated fatigue was associated with alanine aminotransferase (ALT) level. Conclusion The BDI is an adequate tool for ruling out depressive disorders in active IDUs with acute HCV, but specificity is low. Psychiatric consultation is recommended for all active IDUs being considered for acute HCV treatment. PMID:20633748

  6. [Factor models of the Beck Depression Inventory-II. Validation with coronary patients and a critique of Ward's model].

    Science.gov (United States)

    del Pino Pérez, Antonio; Ibáñez Fernández, Ignacio; Bosa Ojeda, Francisco; Dorta González, Ruth; Gaos Miezoso, María Teresa

    2012-02-01

    The objective of this study was to validate in a sample of 205 coronary patients a factor model for the BDI-II, especially a model that would allow for modeling of depressive symptoms after explicitly removing bias related to somatic symptoms of depression that would overlap those of heart disease. Exploratory and confirmatory factor analyses for ordinal data were conducted. A one-factor model, six correlated two-factor models and, derivatives thereof, seven models with a single General Depression factor and two uncorrelated factors, were analyzed. Exploratory analysis extracted two factors, Somatic-affective and Cognitive. Confirmatory factor analyses showed the worst fit for the one-factor model. Two-factor models were surpassed in goodness of fit by the models of general-factor and group factors. Among these, the General, Somatic-affective and Cognitive (G-Sa-C) model of Beck with students is noteworthy. The reduced General, Somatic and Cognitive (G-S-C) model of Ward showed the worst goodness of fit. Our model surpasses the cutoff criteria of all fit indexes. We conclude that the inclusion of a general-factor and group factors in all the models surpasses the results of G-S-C model and, therefore, questions it. The G-Sa-C model is strengthened.

  7. Validation of the Brazilian Portuguese version of the Beck Depression Inventory-II in a community sample.

    Science.gov (United States)

    Gomes-Oliveira, Marcio Henrique; Gorenstein, Clarice; Lotufo Neto, Francisco; Andrade, Laura Helena; Wang, Yuan Pang

    2012-12-01

    The Beck Depression Inventory (BDI) is used worldwide for detecting depressive symptoms. This questionnaire has been revised (1996) to match the DSM-IV criteria for a major depressive episode. We assessed the reliability and the validity of the Brazilian Portuguese version of the BDI-II for non-clinical adults. The questionnaire was applied to 60 college students on two occasions. Afterwards, 182 community-dwelling adults completed the BDI-II, the Self-Report Questionnaire, and the K10 Scale. Trained psychiatrists performed face-to-face interviews with the respondents using the Structured Clinical Interview (SCID-I), the Montgomery-Åsberg Depression Scale, and the Hamilton Anxiety Scale. Descriptive analysis, signal detection analysis (Receiver Operating Characteristics), correlation analysis, and discriminant function analysis were performed to investigate the psychometric properties of the BDI-II. The intraclass correlation coefficient of the BDI-II was 0.89, and the Cronbach's alpha coefficient of internal consistency was 0.93. Taking the SCID as the gold standard, the cut-off point of 10/11 was the best threshold for detecting depression, yielding a sensitivity of 70% and a specificity of 87%. The concurrent validity (a correlation of 0.63-0.93 with scales applied simultaneously) and the predictive ability of the severity level (over 65% correct classification) were acceptable. The BDI-II is reliable and valid for measuring depressive symptomatology among Portuguese-speaking Brazilian non-clinical populations.

  8. Screening for major depression in post-myocardial infarction patients: operating characteristics of the Beck Depression Inventory-II.

    Science.gov (United States)

    Huffman, Jeff C; Doughty, Christopher T; Januzzi, James L; Pirl, William F; Smith, Felicia A; Fricchione, Gregory L

    2010-01-01

    To assess the operating characteristics of the Beck-Depression Inventory-II (BDI-II) and the BDI-II cognitive subscale (BDI-II-cog) in screening for major depression (MDD) in post-myocardial infarction (MI) patients. Between October 2003 and July 2005, 131 post-MI patients admitted to an urban academic medical center completed the BDI-II and a semi-structured interview for depression within 72 hours of symptom onset. Sensitivity, specificity, positive and negative predictive values, overall correct classification, and likelihood ratios for various cutoff values on both scales were evaluated by comparing scores to interview diagnosis of MDD. Receiver-operator curves (ROC) were also calculated and area under the curve (AUC) measured. The optimal cutoff value for the BDI-II was > or = 16, with a sensitivity of 88.2% and a specificity of 92.1%. Cutoff values of > or = 3 or > or = 4 were both acceptable for the BDI-II-cog (sensitivity = 88.2% and 82.4%, respectively; specificity = 81.6% and 88.6 %, respectively). AUC was 0.96 for the BDI-II and 0.89 for the cognitive subscale. Effective depression screening is important in post-MI patients because of depression's independent association with morbidity and mortality following MI. Our results suggest that the BDI-II and its cognitive subscale are effective tools for screening for MDD in post-MI patients.

  9. A confirmatory factor analysis of the Beck Depression Inventory-II in end-stage renal disease patients.

    Science.gov (United States)

    Chilcot, Joseph; Norton, Sam; Wellsted, David; Almond, Mike; Davenport, Andrew; Farrington, Ken

    2011-09-01

    We sought to examine several competing factor structures of the Beck Depression Inventory-II (BDI) in a sample of patients with End-Stage Renal Disease (ESRD), in which setting the factor structure is poorly defined, though depression symptoms are common. In addition, demographic and clinical correlates of the identified factors were examined. The BDI was administered to clinical sample of 460 ESRD patients attending 4 UK renal centres. Competing models of the factor structure of the BDI were evaluated using confirmatory factor analysis. The best fitting model consisted of general depression factor that accounted for 81% of the common variance between all items along with orthogonal cognitive and somatic factors (G-S-C model, CFI=.983, TLI=.979, RMSEA=.037), which explained 8% and 9% of the common variance, respectively. Age, diabetes, and ethnicity were significantly related to the cognitive factor, whereas albumin, dialysis adequacy, and ethnicity were related to the somatic factor. No demographic or clinical variable was associated with the general factor. The general-factor model provides the best fitting and conceptually most acceptable interpretation of the BDI. Furthermore, the cognitive and somatic factors appear to be related to specific demographic and clinical factors. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. Confirmatory factor analysis of the Beck Depression Inventory-II in patients with advanced cancer: A theory-driven approach.

    Science.gov (United States)

    Tobias, Kristen G; Lehrfeld, Jonathan; Rosenfeld, Barry; Pessin, Hayley; Breitbart, William

    2017-08-24

    The diagnosis and treatment of depression are complicated by the presence of a serious medical illness, such as cancer. The role of inflammation in the pathophysiology of depression remains unknown; however, the symptom cluster of sickness behavior is more clearly related to inflammation. Symptom clusters may provide the specificity needed to improve treatment outcomes. The purpose of this study is to use confirmatory factor analysis to examine the construct of sickness behavior in patients with advanced cancer using the Beck Depression Inventory-II (BDI-II). Patients (N = 167) were recruited from chemotherapy clinics and the Department of Psychiatry at Memorial Sloan Kettering Cancer Center. Symptoms were a priori delineated using the factor labels sickness behavior and negative affectivity (two-factor model), and affective, cognitive, and sickness behavior (three-factor model). These data were also fit for a more traditional model using affective, cognitive, and somatic factors. The mean total BDI-II score was 14.74 (SD = 8.52; range = 1-46). Fit statistics for all models were good, but the novel three-factor model with sickness behavior provided the best fit: χ2(186) = 273.624; p factor models provide support for the unique construct of sickness behavior in patients with advanced cancer. High factor correlations with the BDI-II and other measures of distress were observed, which raises questions about theoretically distinct, but related, constructs.

  11. Factorial Structure of Depressive Symptoms in Anglophone Caribbean University Students: Psychometric Properties of the Beck Depression Inventory-II

    Directory of Open Access Journals (Sweden)

    Michael H. Campbell

    2009-01-01

    Full Text Available Este estudio buscó establecer propiedades psicométricas del Inventario de Depresión de Beck-Segunda Edición (BDI-II con estudiantes de una universidad del Caribe (n=400, 76% mujeres, edad media=25.2. Además, administramos la Escala de Elasticidad de Ego-89, La Escala de Tensión Percibida, La Escala de Ansiedad Estado-Rasgo (Versión de Rasgo y La Escala de Depresión de Zung. El análisis factorial confirmativo comparó la estructura observada con las estructuras oblicuas propuestas en los modelos de dos factores. Las estimaciones factoriales y los índices de calidad de ajuste sugirieron adecuado ajuste para modelos de dos factores. La consistencia interna (=.86 y la fiabilidad test-retest (n=57, r=.78 eran fuertes. Las correlaciones de validez eran significativas en las direcciones teóricamente esperadas. Los resultados apoyan el uso del BDI-II con estudiantes del Caribe.

  12. Adaptation of the Beck Hopelessness Scale as a suicide risk screening tool among Nigerian patients with schizophrenia.

    Science.gov (United States)

    Aloba, Olutayo; Esan, Olufemi; Alimi, Taiwo

    2017-08-11

    We examined the adaptation of the Beck Hopelessness Scale (BHS) as a subjective suicide risk assessment tool in detecting Nigerian patients with schizophrenia who are at a high risk of suicide. Schizophrenia patients (211) completed the BHS in addition to a sociodemographic questionnaire. They were objectively interviewed with the suicidality module of the Mini International Neuropsychiatric Interview (MINI) as the 'gold standard', against which the criterion validity of the BHS was examined. The receiver operating characteristics (ROC) curve of the 20-item BHS scale at a total cut-off score of 9 (sensitivity 0.889, specificity 0.916) against the patients' MINI Suicidality Module risk categorisation had an Area Under the Curve (AUC) of 0.96 (95% CI: 0.928-0.987), while, the four-item BHS scale demonstrated a ROC curve with an AUC of 0.92 (95% CI: 0.868-0.966) at a cut-off score of 1 (sensitivity 1.000, specificity 0.832). The BHS has proven to be valid in terms of its sensitivity and specificity in the identification of the high suicidal risk Nigerian schizophrenia outpatients.

  13. Proposal for a short version of the Beck Hopelessness Scale based on a national representative survey in Hungary.

    Science.gov (United States)

    Perczel Forintos, Dóra; Rózsa, Sándor; Pilling, János; Kopp, Mária

    2013-12-01

    In our study we assessed the frequency of reported hopelessness and suicide attempts in the national representative survey Hungarostudy 2002. The randomly selected sample consisted of 14,000 individuals over the age of 18. We created a short version of the widely used Beck Hopelessness Scale for screening purposes in suicide prevention. The short version of the BHS consists of four items and has high internal consistency (Cronbach's alpha = 0.85). Moreover, we conducted an investigation into psychological, somatic, sociological and socio-economic as well as cultural variables that show a positive or negative correlation with hopelessness and important predictors of suicide. The following psychological variables showing a positive correlation with hopelessness were identified: dysfunctional attitudes, exhaustion, psychological distress, hostility, lack of life goals and inability to cope emotionally. Sense of coherence, social support, perceived self-efficiency, subjective well-being and problem-solving coping showed a negative correlation with hopelessness. Concerning the relationship between hopelessness and suicide attempts, we found that participants who attempted suicide in the last year scored higher (mean = 4.86) than participants who attempted suicide more than 3 years ago (mean = 3.57). These results indicate that applying the short version of the BHS could be very useful in general practice and in psychiatric care.

  14. Realization of the thermal equilibrium in inhomogeneous magnetic systems by the Landau-Lifshitz-Gilbert equation with stochastic noise, and its dynamical aspects

    Science.gov (United States)

    Nishino, Masamichi; Miyashita, Seiji

    2015-04-01

    It is crucially important to investigate the effects of temperature on magnetic properties such as critical phenomena, nucleation, pinning, domain wall motion, and coercivity. The Landau-Lifshitz-Gilbert (LLG) equation has been applied extensively to study dynamics of magnetic properties. Approaches of Langevin noises have been developed to introduce the temperature effect into the LLG equation. To have the thermal equilibrium state (canonical distribution) as the steady state, the system parameters must satisfy some condition known as the fluctuation-dissipation relation. In inhomogeneous magnetic systems in which spin magnitudes are different at sites, the condition requires that the ratio between the amplitude of the random noise and the damping parameter depend on the magnitude of the magnetic moment at each site. Focused on inhomogeneous magnetic systems, we systematically showed agreement between the stationary state of the stochastic LLG equation and the corresponding equilibrium state obtained by Monte Carlo simulations in various magnetic systems including dipole-dipole interactions. We demonstrated how violations of the condition result in deviations from the true equilibrium state. We also studied the characteristic features of the dynamics depending on the choice of the parameter set. All the parameter sets satisfying the condition realize the same stationary state (equilibrium state). In contrast, different choices of parameter set cause seriously different relaxation processes. We show two relaxation types, i.e., magnetization reversals with uniform rotation and with nucleation.

  15. Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin.

    Science.gov (United States)

    Schwertner, Harvey A; Vítek, Libor

    2008-05-01

    Serum bilirubin has been shown to be inversely related to cardiovascular disease (CVD) in both retrospective and prospective studies. Meta-analysis of existing studies has also confirmed that serum bilirubin concentrations are inversely related to CVD. Less information is known about the protective effects of slightly elevated serum bilirubin concentrations. In this review, we will focus primarily on the association of serum bilirubin and CVD and the possible protective roles of bilirubin, heme oxygenase (HO), and bilirubin UDP-glucuronosyltransferase (UGT1A1). HO and biliverdin reductase control the formation of bilirubin, whereas UGT1A1 controls bilirubin conjugation and clearance. Because of the health and therapeutic implications of slightly elevated serum bilirubin concentrations, we will discuss the recent prospective studies on cardiovascular risk in individuals with Gilbert syndrome (GS) as well as those with the UGT1A1*28 allele. Such individuals have decreased hepatic bilirubin UDP-glucuronosyltransferase activity, decreased bilirubin clearance, and increased serum bilirubin concentrations. Lastly, we will discuss some of the therapeutic approaches that could be used to increase serum bilirubin concentrations to prevent CVD and other oxidative and inflammatory diseases.

  16. Outcome and toxicities associated to chemotherapy in children with acute lymphoblastic leukemia and Gilbert syndrome. Usefulness of UGT1A1 mutational screening.

    Science.gov (United States)

    Berrueco, R; Alonso-Saladrigues, A; Martorell-Sampol, L; Català-Temprano, A; Ruiz-Llobet, A; Toll, T; Torrebadell, M; Naudó, M; Camós, M; Rives, S

    2015-07-01

    Acute lymphoblastic leukemia (ALL) is the most frequent cancer in childhood. Although intensive chemotherapy has improved survival in those patients, important side effects, including hyperbilirubinemia, are frequent. Gilbert syndrome (GS) is a frequent condition that causes a reduction in glucuronidation and intermittent hyperbilirubinemia episodes. This could provoke a greater exposure to some cytotoxic agents used in ALL, increasing the risk of toxicity. On the other hand, unexplained hyperbilirubinemia could lead to unnecessary modifications or even treatment withdrawals, which could increase the risk of relapse, but data regarding this in ALL pediatric population are scarce. Retrospective study to analyze toxicity, outcome and treatment modifications related to GS in children diagnosed with ALL. A total of 23 of 159 patients were diagnosed with GS. They had statistically higher hyperbilirubinemias during all treatment phases (P < 0.0001) and a slower methotrexate clearance when it was administered during a 24-hr infusion at high doses (patients with GS: 74 hr ± 19 vs. patients without GS: 64 hr ± 8; P <  .002). However, no relevant toxicity or delays in treatment were found in them. Finally, changes in treatment due to hyperbilirubinemia were only done in 5 patients with GS. Differences in outcome were not found in patients with GS. Universal screening for GS appears to be not necessary in pediatric patients with ALL. However, when hyperbilirubinemia is observed, it must be rule out in order to avoid unnecessary changes in treatment. © 2015 Wiley Periodicals, Inc.

  17. Validação da bateria "Beck" de testes de habilidades para atletas brasileiros de "rugby" em cadeira de rodas Validation of beck battery of skills tests to Brazilian players of wheelchair rugby

    Directory of Open Access Journals (Sweden)

    José Irineu Gorla

    2011-09-01

    Full Text Available O "Rugby" em Cadeira de Rodas é uma modalidade praticada por sujeitos com tetraplegia ou tetra-equivalência, desde 2005 no Brasil, onde existem aproximadamente 10 equipes em atividade. A avaliação motora é um dos meios de controle do treinamento que possibilita conquistar avanços no planejamento. A bateria "Beck" de testes de habilidades (manejo de bola, precisão de passes, bloqueio, velocidade e passes de longa distância para atletas da modalidade foi desenvolvida nos EUA por Yilla e Sherrill (1998. O objetivo deste estudo foi analisar os critérios de autenticidade científica da bateria para a população de atletas brasileiros. Os resultados de duas avaliações com a bateria (teste e re-teste realizadas com 11 atletas (média de idade 27,59 ± 5,37 anos, tempo de lesão 8,19 ± 3,83 anos, foram registrados por três avaliadores, o que possibilitou a análise de objetividade, fidedignidade e consistência interna. Foram utilizadas as ferramentas ANOVA para análise de objetividade e, coeficiente de correlação intraclasse e teste t para análise de fidedignidade e consistência. Não foram encontradas diferenças entre os resultados dos diferentes avaliadores (valores de p variando de 0,45 a 1,00 e os valores de correlação intraclasse encontrados (variação de r de 0,78 a 0,99 permitem concluir que a bateria é consistente e fidedigna. Os resultados encontrados neste estudo são evidências de que os critérios de autenticidade científica para a bateria são satisfeitos e a bateria pode ser considerada um instrumento válido para avaliação motora de atletas brasileiros de "rugby" em cadeira de rodas.The Wheelchair Rugby is a sport practiced by subjects with tetraplegia or tetra-equivalence, since 2005 in Brazil, where there are approximately 10 teams in business. The motricity evaluation is a means of training control that allows achieve real progress in planning. The BECK battery of skills tests (ball handling, precision

  18. Sintomas depressivos no câncer de mama: Inventário de Depressão de Beck - Short Form Depressive symptoms in breast cancer: Beck Depression Inventory - Short Form

    Directory of Open Access Journals (Sweden)

    Renata de Oliveira Cangussu

    2010-01-01

    Full Text Available OBJETIVOS: Verificar a prevalência de sintomas depressivos em mulheres com câncer de mama e identificar os fatores de risco associados à sua ocorrência. MÉTODOS: Foi realizado um estudo transversal, em que foram entrevistadas 71 mulheres com câncer de mama. Foram empregados dois instrumentos: um questionário para verificar os dados sociodemográficos e clínicos e o Inventário de Depressão de Beck - Short Form (BDI-SF, para avaliação dos sintomas depressivos. Para análise dos dados, utilizaram-se medidas descritivas e o teste de qui-quadrado, que avaliou a associação entre variáveis sociodemográficas e clínicas e os sintomas depressivos. O nível de significância considerado foi de 5%. RESULTADOS: A prevalência de sintomas depressivos foi de 29,6%. Os fatores associados à presença desses sintomas foram o tratamento quimioterápico (p = 0,021, presença de dor (p = 0,018 e limitação do movimento do membro superior (p = 0,010 e pior percepção da saúde (p = 0,018. CONCLUSÃO: Sintomas depressivos são frequentes no câncer de mama, assim a saúde mental das mulheres com esse tipo de câncer deve ser investigada e tratada quando necessário, reduzindo o impacto desses sintomas na vida da mulher.OBJECTIVES: To verify the prevalence of depressive symptoms in women with breast cancer and identify risk factors associated to its occurrence. METHODS: It was a transversal study where 71 women with breast cancer were interviewed. Two instruments were applied, being one questionnaire used to verify sociodemographic and clinical data, and the Beck Depression Inventory - Short Form to evaluate depressive symptoms. Descriptive methods and chi-square test were utilized to analyze data, evaluating association between depressive symptoms, sociodemographic and clinical data. Significance level was considered of 5%. RESULTS: Depressive symptoms prevalence was 29,6%. Factors associated to the presence of this kind of symptoms were

  19. Distribution and translocation of selenium from soil to highland barley in the Tibetan Plateau Kashin-Beck disease area.

    Science.gov (United States)

    Wang, Jing; Li, Hairong; Yang, Linsheng; Li, Yonghua; Wei, Binggan; Yu, Jiangping; Feng, Fujian

    2017-02-01

    Kashin-Beck disease (KBD), which is still active and severe in the Tibetan Plateau, is considered to be a kind of selenium (Se)-deficient disease. Highland barley as the most popular staple food in the Tibetan Plateau is one of the dominant Se sources for local people. To improve Se levels in crops in the Tibetan Plateau KBD area, the distribution and translocation of Se from soil to highland barley in both non-KBD and KBD endemic areas were investigated. The results showed that Se levels in highland barley were too low to meet the minimum requirements of human for daily intake of Se. The total Se concentrations of highland barley fractions in KBD areas were lower than that in non-KBD areas (grain P = 0.238; straw P = 0.087; root P = 0.008). However, no significant difference was observed in corresponding cultivated soil Se between the two areas (P = 0.993). The calculation of Se transfer factors indicated that the restricting step for Se translocation was from soil to root. Water-soluble, exchangeable and fulvic acid-bound Se fractions in the soil are key species dominating in this transfer process, according to their significant correlations with root Se. Se transfer from soil to root significantly increases as the pH value of soil increases (P = 0.007), and soil organic matter content decreases (P = 0.019). The information obtained may have considerable significance for proposing effective agricultural measures to increase grain Se in KBD endemic areas.

  20. Beck Depression Inventory (BDI) in patients with breast disease and breast cancer: a prospective case-control study.

    Science.gov (United States)

    Eskelinen, Matti; Ollonen, Paula

    2011-01-01

    In 1972, Beck introduced an inventory (BDI) for rapid screening of depression. The associations between the BDI and the risk of breast cancer (BC) are rarely considered together in prospective studies. In an extension of the Kuopio Breast Cancer Study, 115 women with breast cancer symptoms were semi-structurally interviewed in-depth as well as asked to complete standardised questionnaires (Forsen, Spielberger, MADRS), and all study variables were obtained before any diagnostic procedures were carried out. BDI was used to evaluate the depression of the study participants. The clinical examinations and biopsies showed BC in 34 patients, benign breast disease (BBD) in 53 patients, and 28 individuals were shown to be healthy (HSS). There was a trend for the women with HSS to have less sadness (BDI mean score, 0.27) than those of the BC (BDI mean score, 0.56) and BBD groups (BDI mean score, 0.49). The HSS group tended to be less pessimistic (BDI mean score, 0.15) than the patients in the BC group (BDI mean score, 0.44) and in the BBD group (BDI mean score, 0.42). The HSS group also had less self-accusation (BDI mean score, 0.19) than the patients in the BC group (BDI mean score, 0.50) and the patients in the BBD group (BDI mean score, 0.62). The HSS group also reported less work inhibition and weight loss than the patients in the BC group and in the BBD group. The mean sum of the scores of BDI variables was significantly lower in the HSS group (BDI mean score, 7.1) than in the BC (BDI mean score, 8.4) or BBD groups (BDI mean score, 8.8). The results of this study do not support a specific link between BDI and breast cancer risk. However, the patients with BC and BBD tended to have an increased risk for depressive symptoms.

  1. Dimensional and hierarchical models of depression using the Beck Depression Inventory-II in an Arab college student sample

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    Ohaeri Jude U

    2010-07-01

    Full Text Available Abstract Background An understanding of depressive symptomatology from the perspective of confirmatory factor analysis (CFA could facilitate valid and interpretable comparisons across cultures. The objectives of the study were: (i using the responses of a sample of Arab college students to the Beck Depression Inventory (BDI-II in CFA, to compare the "goodness of fit" indices of the original dimensional three-and two-factor first-order models, and their modifications, with the corresponding hierarchical models (i.e., higher - order and bifactor models; (ii to assess the psychometric characteristics of the BDI-II, including convergent/discriminant validity with the Hopkins Symptom Checklist (HSCL-25. Method Participants (N = 624 were Kuwaiti national college students, who completed the questionnaires in class. CFA was done by AMOS, version 16. Eleven models were compared using eight "fit" indices. Results In CFA, all the models met most "fit" criteria. While the higher-order model did not provide improved fit over the dimensional first - order factor models, the bifactor model (BFM had the best fit indices (CMNI/DF = 1.73; GFI = 0.96; RMSEA = 0.034. All regression weights of the dimensional models were significantly different from zero (P Conclusion The broadly adequate fit of the various models indicates that they have some merit and implies that the relationship between the domains of depression probably contains hierarchical and dimensional elements. The bifactor model is emerging as the best way to account for the clinical heterogeneity of depression. The psychometric characteristics of the BDI-II lend support to our CFA results.

  2. Sensitivity and specificity of the Beck Depression Inventory in cardiologic inpatients: how useful is the conventional cut-off score?

    Science.gov (United States)

    Forkmann, Thomas; Vehren, Thomas; Boecker, Maren; Norra, Christine; Wirtz, Markus; Gauggel, Siegfried

    2009-10-01

    The Beck Depression Inventory (BDI) is widely used for depression screening in various patient populations. However, there are still insufficient data about its sensitivity and specificity in nonpsychiatric patients. Furthermore, some research suggests that somatic BDI items heighten its sum score artificially in physically ill patients. The aim of the present study was to validate the conventional BDI cut-off score by examination of its sensitivity and specificity in a mixed sample of cardiac inpatients and compare it to a modified "cognitive-emotional" BDI (BDI(c/e)) after exclusion of somatic items. A total of 126 cardiologic inpatients were assessed. Receiver operating characteristic curves (ROC) were calculated for total BDI (BDI(t)) and BDI(c/e). Screening performance of cut-off scores was evaluated using the Youden Index (Y). With the application of the conventional BDI cut-off score, ROC analysis revealed a moderate overall screening performance with Y=52.6 and an area under the curve (AUC) of 0.83. In contrast, Y improved to 57.5 at a cut-off score of >9, but screening performance was still not optimal. BDI(c/e) showed also a moderate screening performance (AUC=.82); Y was maximized at a cut-off score of >8 (Y=0.53.5). Again, no cut-off score provided optimal screening performance. The BDI cannot be recommended as a formal screening instrument in cardiac inpatients since no cut-off score for either BDI(t) or BDI(c/e) combined both sufficiently high sensitivity and specificity. However, the shorter BDI(c/e) could be used as alternative to BDI(t) which may be confounded in physically ill patients. Generally, researchers should consider using alternative screening instruments (e.g., the Hospital Anxiety and Depression Scale) instead.

  3. Validity of the Beck Depression Inventory as a screening tool for a clinical mood disorder in bariatric surgery candidates.

    Science.gov (United States)

    Hayden, Melissa J; Brown, Wendy A; Brennan, Leah; O'Brien, Paul E

    2012-11-01

    The Beck Depression Inventory (BDI) is one of the most commonly used instruments to assess depression in persons with obesity. While it has been validated in normal and psychiatric populations, in obese populations, its validity remains uncertain. This study aimed to investigate the validity and reliability of the BDI-IA and BDI-II in severely obese bariatric surgery candidates. Consecutive new candidates at a bariatric surgery clinic were invited to participate in the study by their consulting surgeon. All candidates were assessed using the Structured Clinical Interview for DSM-IV Disorders (SCID-I); 118 completed the BDI-IA and 83 completed the BDI-II. Two hundred one patients (response rate, 88 %) participated in the study. The current sample (82 % female) had an average body mass index of 42.83 ± 6.34 and an average age of 45 ± 12 years. Based on the SCID-I, 54 candidates (26.9 %) met the criteria for a mood disorder, with 37 meeting the criteria for current major depressive disorder. Individuals diagnosed with a clinical mood disorder had significantly higher scores on the BDI (BDI-IA, 23.59 ± 9.69 vs. 12.76 ± 8.29; BDI-II, 22.93 ± 5.22 vs. 11.25 ± 8.44). Our results indicated that, as a screening tool for a clinical mood disorder, the BDI-II had an optimal cutoff of 13, with a sensitivity of 100 and specificity of 67.75. Results indicated that the BDI-IA should not be used as a tool to measure depressive symptomatology in obese bariatric surgery candidates. No cutoff was identified with adequate sensitivity and specificity, and over 20 % of patients were misclassified. As a screening tool for a clinical mood disorder, the BDI-II was adequate; however, prevalence rates were significantly overestimated.

  4. Dimensional and hierarchical models of depression using the Beck Depression Inventory-II in an Arab college student sample.

    Science.gov (United States)

    Al-Turkait, Fawziyah A; Ohaeri, Jude U

    2010-07-29

    An understanding of depressive symptomatology from the perspective of confirmatory factor analysis (CFA) could facilitate valid and interpretable comparisons across cultures. The objectives of the study were: (i) using the responses of a sample of Arab college students to the Beck Depression Inventory (BDI-II) in CFA, to compare the "goodness of fit" indices of the original dimensional three-and two-factor first-order models, and their modifications, with the corresponding hierarchical models (i.e., higher - order and bifactor models); (ii) to assess the psychometric characteristics of the BDI-II, including convergent/discriminant validity with the Hopkins Symptom Checklist (HSCL-25). Participants (N = 624) were Kuwaiti national college students, who completed the questionnaires in class. CFA was done by AMOS, version 16. Eleven models were compared using eight "fit" indices. In CFA, all the models met most "fit" criteria. While the higher-order model did not provide improved fit over the dimensional first - order factor models, the bifactor model (BFM) had the best fit indices (CMNI/DF = 1.73; GFI = 0.96; RMSEA = 0.034). All regression weights of the dimensional models were significantly different from zero (P depression factor, indicating that the general depression score is an adequate representation of severity. The BDI-II had adequate internal consistency and convergent/discriminant validity. The mean BDI score (15.5, SD = 8.5) was significantly higher than those of students from other countries (P depression probably contains hierarchical and dimensional elements. The bifactor model is emerging as the best way to account for the clinical heterogeneity of depression. The psychometric characteristics of the BDI-II lend support to our CFA results.

  5. Factor Structure and Clinical Utility of the Beck Depression Inventory in Patients with Binge Eating Disorder and Obesity

    Science.gov (United States)

    Udo, Tomoko; McKee, Sherry A.; Grilo, Carlos M.

    2015-01-01

    Objective The Beck Depression Inventory (BDI) is often used to assess depression symptoms, but its factor structure and clinical utility have not been evaluated in patients with binge eating disorder (BED) and obesity. Methods 882 treatment-seeking obese patients with BED were administered structured interviews (SCID-I/P) and completed self-report questionnaires. Results Exploratory and confirmatory factor analyses supported a brief 16-item BDI version with a three-factor structure (affective, attitudinal, and somatic). Both 21- and 16-item versions showed excellent internal consistency (both α=0.89) and had significant correlation patterns with different aspects of eating disorder psychopathology; three factors showed significant but variable associations with eating disorder psychopathology. Area under the curves (AUC) for both BDI versions were significant in predicting major depressive disorder (MDD; AUC=0.773 [16-item], 73.5% sensitivity/70.2% specificity, AUC=0.769 [21-item], 79.5% sensitivity/64.1% specificity) and mood disorders (AUC=0.763 [16-item], 67.1% sensitivity/71.5% specificity, AUC=0.769 [21-item], 84.2% sensitivity/55.7% specificity). 21-item BDI (cut-off score ≥16) showed higher negative predictive values (94.0% vs. 93.0% [MDD]; 92.4% vs. 88.3% [mood disorders]) than brief 16-item BDI (cut-off score ≥13). Conclusions Both BDI versions demonstrated moderate performance as a screening instrument for MDD/mood disorders in obese patients with BED. Advantages and disadvantages for both versions are discussed. A three-factor structure has potential to inform the conceptualization of depression features. PMID:25537344

  6. Factor structure and clinical utility of the Beck depression inventory in patients with binge eating disorder and obesity.

    Science.gov (United States)

    Udo, Tomoko; McKee, Sherry A; Grilo, Carlos M

    2015-01-01

    The Beck Depression Inventory (BDI) is often used to assess depression symptoms, but its factor structure and its clinical utility have not been evaluated in patients with binge eating disorder (BED) and obesity. A total of 882 treatment-seeking obese patients with BED were administered structured interviews (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I Disorders) and completed self-report questionnaires. Exploratory and confirmatory factor analyses supported a brief 16-item BDI version with a three-factor structure (affective, attitudinal and somatic). Both 21- and 16-item versions showed excellent internal consistency (both α=0.89) and had significant correlation patterns with different aspects of eating disorder psychopathology; three factors showed significant but variable associations with eating disorder psychopathology. Area under the curves (AUC) for both BDI versions were significant in predicting major depressive disorder (MDD; AUC=0.773 [16-item], 73.5% sensitivity/70.2% specificity, AUC=0.769 [21-item], 79.5% sensitivity/64.1% specificity) and mood disorders (AUC=0.763 [16-item], 67.1% sensitivity/71.5% specificity, AUC=0.769 [21-item], 84.2% sensitivity/55.7% specificity). The 21-item BDI (cutoff score ≥16) showed higher negative predictive values (94.0% vs. 93.0% [MDD]; 92.4% vs. 88.3% [mood disorders]) than the brief 16-item BDI (cutoff score ≥13). Both BDI versions demonstrated moderate performance as a screening instrument for MDD/mood disorders in obese patients with BED. Advantages and disadvantages for both versions are discussed. A three-factor structure has potential to inform the conceptualization of depression features. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Is It the Appropriate Time to Stop Applying Selenium Enriched Salt in Kashin-Beck Disease Areas in China?

    Directory of Open Access Journals (Sweden)

    Yujie Ning

    2015-07-01

    Full Text Available We aimed to identify significant factors of selenium (Se nutrition of children in Kashin-Beck disease (KBD endemic areas and non-KBD area in Shaanxi Province for providing evidence of whether it is the time to stop applying Se-enriched salt in KBD areas. A cross-sectional study contained 368 stratified randomly selected children aged 4–14 years was conducted with 24-h retrospective questionnaire based on a pre-investigation. Food and hair samples were collected and had Se contents determined with hydride generation atomic fluorescence spectrometry. Average hair Se content of 349.0 ± 60.2 ng/g in KBD-endemic counties was significantly lower than 374.1 ± 47.0 ng/g in non-KBD counties. It was significantly higher in the male children (365.2 ± 52.3 ng/g than in the female (345.0 ± 62.2 ng/g, p = 0.002 and significantly higher in the 4.0–6.9 years group (375.2 ± 58.9 ng/g than the 7.0–14.0 years group (347.0 ± 56.1 ng/g, p < 0.01. Gender, living area, Se intake without supplements, Se-enriched salt, oil source and protein intake were identified as significant factors of hair Se contents. Cereals, meat and milk were commonly included as significant food categories that mainly contributed to Se intake without supplement of the whole population. Balanced dietary structure without Se supplement could effectively enhance and maintain children’s Se nutrition. It may be the time to stop applying Se-enriched salt in KBD areas in Shaanxi Province.

  8. Can we predict suicide and non-fatal self-harm with the Beck Hopelessness Scale? A meta-analysis.

    Science.gov (United States)

    McMillan, Dean; Gilbody, Simon; Beresford, Emma; Neilly, Liz

    2007-06-01

    Hopelessness is considered a pre-eminent risk factor for suicide and non-fatal self-harm. We aimed to quantify the ability of the Beck Hopelessness Scale (BHS) to predict these two outcomes. Medline, Embase, PsycINFO and Cinahl were searched to January 2006. We included cohort studies in which the BHS was applied and patients were followed-up to establish subsequent suicide or non-fatal self-harm. Four studies provided usable data on suicide, and six studies provided data on non-fatal self-harm. Summary sensitivity, specificity, likelihood ratios and diagnostic odds ratios (DORs) were calculated for each study. Random effects meta-analytic pooling across studies at the standard cut-off point (> or =9) was undertaken and summary receiver operating characteristic (ROC) curves constructed. For suicide, pooled sensitivity was 0.80 [95% confidence interval (CI) 0.68-0.90], pooled specificity was 0.42 (95% CI 0.41-0.44), and the pooled DOR was 3.39 (95% CI 1.29-8.88). For non-fatal self-harm, pooled sensitivity was 0.78 (95% CI 0.74-0.82), pooled specificity was 0.42 (95% CI 0.38-0.45), and the pooled DOR was 2.27 (95% CI 1.53-3.37). The standard cut-off point on the BHS identifies a high-risk group for potential suicide, but the magnitude of the risk is lower than previously reported estimates. The standard cut-off point is also capable of identifying those who are at risk of future self-harm, but the low specificity rate means it is unlikely to be of use in targeting treatment designed to lower the rate of repetition.

  9. Is the beck anxiety inventory a good tool to assess the severity of anxiety? A primary care study in The Netherlands study of depression and anxiety (NESDA)

    OpenAIRE

    van der Feltz-Cornelis Christina M; Muntingh Anna DT; van Marwijk Harm WJ; Spinhoven Philip; Penninx Brenda WJH; van Balkom Anton JLM

    2011-01-01

    Abstract Background Appropriate management of anxiety disorders in primary care requires clinical assessment and monitoring of the severity of the anxiety. This study focuses on the Beck Anxiety Inventory (BAI) as a severity indicator for anxiety in primary care patients with different anxiety disorders (social phobia, panic disorder with or without agoraphobia, agoraphobia or generalized anxiety disorder), depressive disorders or no disorder (controls). Methods Participants were 1601 primary...

  10. Guido Beck and the night of the long police batons: some observations about the relationship between physics and politics in the Argentinean context

    Directory of Open Access Journals (Sweden)

    Antonio Augusto Passos Videira

    2009-12-01

    Full Text Available The objective of this paper consists in presenting the reaction of the physicist Guido Beck (1903-1988 towards the political events that occurred in the University of Buenos Aires (UBA, during the second term of 1966. It is not our intention to write a deep treatise on the problem, but to outline some of the ideas that Guido Beck had on the relation between science, State and society in South-American context. That will be done by describing his reaction to the well-known ‘night of the long police batons’. Beck had always been sensitive to the political instability in Argentinean academic system, once that political and ideological disputes could jeopardize the work towards the establishment of a scientific community in that country. As a conclusion, I defend the thesis that in Beck’s point of view the physicists at UBA had misunderstood the importance they had to Argentinean government and to part of the population in that same country.

  11. Snapback primer genotyping of the Gilbert syndrome UGT1A1 (TA)(n) promoter polymorphism by high-resolution melting.

    Science.gov (United States)

    Farrar, Jared S; Palais, Robert A; Wittwer, Carl T

    2011-09-01

    Gilbert syndrome, a chronic nonhemolytic unconjugated hyperbilirubinemia, is associated with thymine-adenine (TA) insertions in the UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide A1) promoter. The UGT1A1 promoter genotype also correlates with toxicity induced by the chemotherapeutic drug irinotecan. Current closed-tube assays for genotyping the UGT1A1 (TA)(n) promoter polymorphism require multiple labeled probes and/or have difficulty classifying the (TA)(5) and (TA)(8) alleles. An unlabeled 5' extension on one primer that creates a hairpin after asymmetric PCR was used to develop a snapback primer high-resolution melting assay for the (TA)(n) polymorphism. A new method that plots the local deviation from exponential decay to improve genotype clustering was used to remove background fluorescence and to analyze the data. The snapback assay was compared with small-amplicon melting and fragment length analyses in a blinded study of DNA samples from 100 African Americans. Genotyping results obtained by small-amplicon melting and snapback primer melting were 83% and 99% concordant, respectively, with results obtained by fragment analysis. Reanalysis of the single discordant sample in the results of the snapback genotyping assay and the fragment analysis revealed an error in the fragment analysis. High-resolution melting was required for accurate snapback genotyping of the UGT1A1 (TA)(n) polymorphism. The 100% accuracy obtained with a capillary-based instrument fell to ≤81% with plate-based instruments. In contrast to small-amplicon genotyping, snapback primer genotyping can distinguish all UGT1A1 promoter genotypes. Rapid-cycle PCR combined with snapback primer analysis with only 2 unlabeled PCR primers (one with a 5' extension) and a saturating DNA dye can genotype loci with several alleles in <30 min.

  12. Reliability and validity of the EQ-5D-3L for Kashin-Beck disease in China.

    Science.gov (United States)

    Fang, Hua; Farooq, Umer; Wang, Dimiao; Yu, Fangfang; Younus, Mohammad Imran; Guo, Xiong

    2016-01-01

    Kashin-Beck Disease (KBD) is an endemic osteoarthropathy in areas which extend from the North-East to the South-West of China. Most of the patients with KBD suffer multiple dysfunctions in major joints causing decreased health status. However because of their low education level and unique living habits, it is hard to find tools to measure the health-related quality of life (HRQOL). European quality of life (EQ-5D-3L) patient-reported instrument is widely used to measure HRQOL. This study aimed to establish the validity and reliability of the Chinese version of the EQ-5D-3L for evaluating HRQOL of KBD individuals in rural area. 368 individuals who were suffering from KBD were recruited through stratified multistage random sampling from Shaanxi province, China. The EQ-5D-3L and the WHOQOL-BREF were administrated in each individual by face to face interview. Test-retest reliability was assessed at 10-14 days intervals. The test-retest reliability was measured by calculating the Kappa coefficients for EQ-5D-3L five dimensions. For the EQ VAS, the intraclass correlation coefficient (ICC) was computed. Convergent and divergent analysis, construct validity was established using Spearman's rank correlation between the EQ-5D-3L and the WHOQOL-BREF. Known groups' validity was examined by comparing groups with a priori expected differences in health-related quality of life (HRQOL). For 362 individuals (98%), comprehensive data of all the EQ-5D-3L dimensions were available. Kappa values of the EQ-5D-3L five items ranged from 0.324 to 0.554. ICC of the EQ VAS was 0.497. For convergent validity, the three items (self-care, usual activity, and mobility) of EQ-5D-3L, index scores, and VAS showed moderate correlations with the physical health domain of the WHOQOL-BREF (r absolute value ranged from 0.339 to 0.475). For divergent validity, the 5 items of EQ-5D-3L showed weak or no correlations with environment and social relationship domains of WHOQOL-BREF. The Chinese EQ-5D-3L

  13. [Analysis on allele frequencies of 7 short tandem repeat loci of Kashing-Beck disease patients on].

    Science.gov (United States)

    Kang, Long-li; Guo, Xiong; Zuo, Hong; Ping, Zhi-guang; Zhang, Bao-di; Lai, Jianghua; Geng, Dong

    2005-10-01

    To analyze the allele frequencies of 7 short tandem repeat (STR) loci (D12S1718, D12S1675, D12S358, D12S367, D12S1638, D12S1646 and D12S1682) on chromosome 12 among Kashing-Beck disease (KBD) patients and the control population living in the KBD areas and non-KBD area. EDTA-blood specimens were collected from 102 unrelated individuals of Chinese Han population in Shaanxi province including 29 KBD patients,30 controls living in the KBD area and 43 living in the non-KBD area. DNA samples were extracted using the Wizard Genomic DNA purification kit (http://www. Promega. com) and were amplified by polymerase chain reaction (PCR) technique. The PCR products were analyzed by ABI 3100 Genetic Analyzer. (1) In KBD patients group, the allele number for 7 STR loci were 4,7,7,8,5,5 and 7, the genotype number were 5,12,13,11,10,9 and 13; (2) In the control population living in KBD area, the allele number for 7 STR loci were 4,9,7,6,6,6 and 8,t he genotype number were 5,10,12,14,12,9 and 13;(3) In the control population living in the non-KBD area, the allele number for 7 STR loci were 7,9,7,7,5,8 and 11, the genotype number were 9,16, 17,16,12,15 and 20;(4) Compared with the allele frequencies among three groups, there were significant differences between KBD patients and the controls living in the KBD area (D12S367: P = 0.034; D12S1638: P = 0.041) and the controls living in the non-KBD area (D12S367: P = 0. 029; D12S1638: P= 0 .028) in the D12S367 and D12S1638 loci; (5) There were significant differences among KBD patients (P = 0.036), controls living in the KBD area (P = 0.039) and controls living in the non-KBD area in the D12S1646. There was significant difference between KBD patients and the controls in the D12S367 and D12S1638 loci.

  14. Mapping the Beck Depression Inventory to the EQ-5D-3L in Patients with Depressive Disorders.

    Science.gov (United States)

    Grochtdreis, Thomas; Brettschneider, Christian; Hajek, Andr; Schierz, Katharina; Hoyer, Juergen; Koenig, Hans-Helmut

    2016-06-01

    For cost-utility analyses, data on health state utilities, as provided by the EQ-5D-3L, is needed but not always available. This study specified mapping algorithms from the Beck Depression Inventory (BDI) index to the EQ-5D-3L index adjusted for specific socio-demographic variables for patients with depressive disorders. The objective of this study was to specify mapping algorithms from the BDI index to the preference-based EQ-5D index for patients with depressive disorders, adjusting for specific socio-demographic variables. A sample of 1,074 consecutive patients with depressive disorders from a psychotherapeutic outpatient clinic was included in the study. Standardized clinical interviews were applied to establish reliable diagnoses. For the prediction of the EQ-5D-3L index from the BDI index and selected patient socio-demographic characteristics, ordinary least squares regression with robust standard errors was used. Model prediction properties were tested using the root mean squared error and repeated random sub-sampling cross-validation. The BDI index predicted the EQ-5D-3L index with a significant proportion of variance explained. The highest model goodness of fit was estimated for models with the BDI index and age as independent variables. The root mean squared error of the predicted EQ-5D-3L index in the validation samples was 0.23 for all models. The mean observed EQ-5D-3L index values and the mean predicted EQ-5D-3L index values seemed not to differ between models. However, a reduction of variability using cross-validation led to those (rather) accurate mean predicted values. One limitation of this study was the restricted generalizability. Moreover, some uncertainty was introduced in model predictive performance by usage of a dependent estimation sample for validation. The specified mapping algorithms from the BDI index to the EQ-5D-3L index for patients with depressive disorders are acceptable as approximation in cost-utility analyses. A further

  15. [Manfred Schneider. Lübeck im 12. und 13. Jahrhundert. Archäologische Befunde zur entstehung einer mittelalterlichen Grossstadt. In : Expansion - integration? Danish-Baltic Contacts 1147-1410] / Dennis Hortmuth

    Index Scriptorium Estoniae

    Hortmuth, Dennis

    2011-01-01

    Arvustus:Manfred Schneider. Lübeck im 12. und 13. Jahrhundert. Archäologische Befunde zur entstehung einer mittelalterlichen Grossstadt. In : Expansion - integration? Danish-Baltic Contacts 1147-1410 AD. (Vordingborg, 2009).

  16. Aspectos reprodutivos de Sphoeroides greeleyi (Gilbert, Pisces, Osteichthyes, Tetraodontidae, da gamboa do Baguaçu, Baia De Paranaguá, Paraná, Brasil Reproductive aspects of Sphoeroides greeleyi (Gilbert, Tetraodontidae, from gamboa do Baguaçu, Paranaguá, State of Paraná, Brazil

    Directory of Open Access Journals (Sweden)

    Yart Damasceno Schultz

    2002-03-01

    Full Text Available The present study analyses the reproductive aspects of Sphoeroides greeleyi (Gilbert, 1900, such as morphology and histochemistry of carbohydrates in the oogenesis phases, maturity scale, time and type of spawn, sexual rate and first ripened mature size for females. From the monthly captured animais (Nov 1998 to Nov 1999 the morphometric data (entire length and total weight were extracted and the sex and the gonadal maturity were determined. Some ovaries were prepared for microscopic analysis that charac-terized six phases for the development of the ovarian folheies. Through the carbohydrates analysis the acid carbohydrates could be related to the oogenesis maintenance and the neutral carbohydrates to the beginning of embryonic development. A maturity scale containing six stages of gonadal development was determined. The reproductive period is between August and January and the spawn time is from October to January. The first ripened mature size for females oceurs between 6,5cm and 7.5 cm of total length. The sexual rate shows that there are more females than males during the reproductive period.

  17. Differences in UGT1A1 gene mutations and pathological liver changes between Chinese patients with Gilbert syndrome and Crigler-Najjar syndrome type II.

    Science.gov (United States)

    Sun, Lei; Li, Man; Zhang, Liang; Teng, Xiaoying; Chen, Xiangmei; Zhou, Xingang; Ma, Zhiyuan; Qi, Liming; Wang, Peng

    2017-11-01

    Diagnosis of Crigler-Najjar syndrome type II (CNS-II) and Gilbert syndrome (GS) based on the serum bilirubin concentration is difficult, because this parameter can fluctuate under certain conditions. The aim of this study was to explore differences in UGT1A1 gene mutations, which cause both CNS and GS, and pathological changes between CNS-II and GS.Ninety-five Chinese patients with hereditary unconjugated hyperbilirubinemia were enrolled in this study. Peripheral blood samples obtained from patients were used to evaluate bilirubin levels and for UGT1A1 gene testing. Percutaneous needle biopsy of the liver and staining of tissue samples with hematoxylin and eosin, Masson trichrome, reticulin, and Perl Prussian blue were performed for 59 patients. The Ishak scoring system was used to assess inflammatory activity and the extent of fibrosis.One hundred ninety-two UGT1A1 mutations at 6 sites were detected in the 95 patients; the most common mutation in GS was c.-3279T>G in the phenobarbital response enhancing motif of the UGT1A1 promoter, whereas the most common mutation in CNS-II was p.G71R. The frequency of heterozygous p.G71R mutations in CNS-II was significantly higher than that in GS (P = .001); however, the frequency of homozygous c.-3279T>G mutations in CNS-II was markedly lower than that in GS (P = .032). Among all patients with multiple mutations, the frequency of p.Y486D was significantly higher in CNS-II than in GS (P = .007). The frequency of compound c.-3279T>G, A(TA)7TAA, and p.G71R mutations in CNS-II was significantly higher than that in GS (P = .001). Among the 59 patients who underwent percutaneous needle biopsy, 20 had iron deposition in the liver. The frequency of hepatic iron deposition in CNS-II was significantly higher than that in GS (P = .002).The linked polymorphic mutations, A(TA)7TAA and c.-3279T>G in UGT1A1, were most strongly associated with GS, whereas mutations in the coding region, especially p.G71R and p.Y486D, were

  18. Genetics Home Reference: Gilbert syndrome

    Science.gov (United States)

    ... instance because of dehydration, prolonged periods without food (fasting), illness, vigorous exercise, or menstruation. Some people with ... but some mutations occur more often in particular populations. In many populations, the most common genetic change ...

  19. The Beck Depression Inventory (BDI-II) and a single screening question as screening tools for depressive disorder in Dutch advanced cancer patients.

    Science.gov (United States)

    Warmenhoven, Franca; van Rijswijk, Eric; Engels, Yvonne; Kan, Cornelis; Prins, Judith; van Weel, Chris; Vissers, Kris

    2012-02-01

    Depression is highly prevalent in advanced cancer patients, but the diagnosis of depressive disorder in patients with advanced cancer is difficult. Screening instruments could facilitate diagnosing depressive disorder in patients with advanced cancer. The aim of this study was to determine the validity of the Beck Depression Inventory (BDI-II) and a single screening question as screening tools for depressive disorder in advanced cancer patients. Patients with advanced metastatic disease, visiting the outpatient palliative care department, were asked to fill out a self-questionnaire containing the Beck Depression Inventory (BDI-II) and a single screening question "Are you feeling depressed?" The mood section of the PRIME-MD was used as a gold standard. Sixty-one patients with advanced metastatic disease were eligible to be included in the study. Complete data were obtained from 46 patients. The area under the curve of the receiver operating characteristics analysis of the BDI-II was 0.82. The optimal cut-off point of the BDI-II was 16 with a sensitivity of 90% and a specificity of 69%. The single screening question showed a sensitivity of 50% and a specificity of 94%. The BDI-II seems an adequate screening tool for a depressive disorder in advanced cancer patients. The sensitivity of a single screening question is poor.

  20. The Effect of Beck's Cognitive Therapy and Mindfulness-Based Cognitive Therapy on Sociotropic and Autonomous Personality Styles in Patients With Depression.

    Science.gov (United States)

    Abolghasemi, Abbas; Gholami, Hossin; Narimani, Mohammad; Gamji, Masood

    2015-12-01

    Depression is characterized by a great risk of relapse and recurrence. Mindfulness-based cognitive therapy (MBCT) and cognitive therapy are efficacious psychosocial interventions for recurrent depression. The aim of the present research was to compare the effect of Beck's cognitive therapy (BCT) and MBCT on reduction of depression and sociotropic and autonomous personality styles in Iranian depressed patients. The study sample consisted of 30 subjects randomly selected from patients with depression in Mashhad city, Iran. The subjects were assigned randomly to experimental groups. The 2 techniques used for treatment were BCT and MBCT. The data collection instruments used in the research consisted of psychological interview, the Beck Depression Inventory II and the revised Personal Style Inventory (RPSI). The research data was analyzed using repeated measures analysis of variance (ANOVA). BCT and MBCT were effective in reducing depression, but BCT and MBCT did not cause any change in the sociotropic and autonomous personality styles in patients with depression. The results provide support for the role of BCT and MBCT plays in reducing depression. However, the results did not approve their role in changing sociotropic and autonomous personality styles in patients with depression.

  1. Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease.

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    Charlene M Downey

    2009-08-01

    Full Text Available Kashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia. The disease has been postulated to result from a combination of different environmental factors, including contamination of barley by mold mycotoxins, iodine deficiency, presence of humic substances in drinking water, and, importantly, deficiency of selenium. This multifunctional trace element, in the form of selenocysteine, is essential for normal selenoprotein function, including attenuation of excessive oxidative stress, and for the control of redox-sensitive molecules involved in cell growth and differentiation. To investigate the effects of skeletal selenoprotein deficiency, a Cre recombinase transgenic mouse line was used to trigger Trsp gene deletions in osteo-chondroprogenitors. Trsp encodes selenocysteine tRNA([Ser]Sec, required for the incorporation of selenocysteine residues into selenoproteins. The mutant mice exhibited growth retardation, epiphyseal growth plate abnormalities, and delayed skeletal ossification, as well as marked chondronecrosis of articular, auricular, and tracheal cartilages. Phenotypically, the mice thus replicated a number of the pathological features of Kashin-Beck disease, supporting the notion that selenium deficiency is important to the development of this syndrome.

  2. The Yoruba version of the Beck Hopelessness Scale: psychometric characteristics and correlates of hopelessness in a sample of Nigerian psychiatric outpatients.

    Science.gov (United States)

    Aloba, Olutayo; Akinsulore, Adesanmi; Mapayi, Boladale; Oloniniyi, Ibiduniyi; Mosaku, Kolawole; Alimi, Taiwo; Esan, Olufemi

    2015-01-01

    Previous studies from the developed western countries have repeatedly demonstrated that hopelessness positively correlates with an increased risk of suicide in the context of chronic mental disorders such as schizophrenia and affective disorders. Despite this persistently strong association, the construct of hopelessness in terms of its factorial structure and correlates has not been explored among Nigerian psychiatric outpatients. The aim of this present study is to examine the psychometric characteristics of the Yoruba language culturally adapted version of the Beck Hopelessness Scale in a cross-sectional sample of psychiatric outpatients in South-western Nigeria. The participants were 327 Nigerian adult outpatients receiving treatment for schizophrenia, bipolar and depressive disorders, consecutively recruited from the outpatient psychiatric clinics of a university teaching hospital in South-western Nigeria. The outpatients were recruited over a one year period. They completed the Yoruba translated version of the Beck Hopelessness Scale (BHS-Y), a sociodemographic and illness-related questionnaire, the Beck Depression Inventory-II (BDI-II). Their level of functioning was assessed with the Global Assessment of Functioning Scale (GAF), psychopathology was evaluated with the Positive and Negative Syndrome Scale (PANSS) and the level of disability measured with the World Health Organization Disability Assessment Schedule (WHODAS-II). Suicidality and confirmation of the diagnoses of schizophrenia, bipolar and depressive disorders were evaluated with the Mini International Neuropsychiatric Interview (MINI). The construct of hopelessness in terms of factorial structure, reliability, validity and correlates was explored. Exploratory Factor Analysis using Principal Component Analysis with Varimax rotation was used to examine the factorial structure of the BHS-Y. Internal consistency was examined with Cronbach's alpha, and the construct validity of the scale was assessed

  3. 50 YEARS OF THE BECK DEPRESSION INVENTORY: RECOMMENDATIONS FOR USING THE SPANISH ADAPTATION OF THE BDI-II IN CLINICAL PRACTICE

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    Jesús Sanz

    2013-09-01

    Full Text Available The first Spanish adaptation of the Beck Depression Inventory-II (BDI-I was published in 2011, which happened to be the 50th anniversary of the publication of its first edition. In this time, the BDI has become the most widely-used self-report questionnaire in Spain and in the world for evaluating the severity of depression. In this study, the basic characteristics of the BDI-II are presented and compared with its earlier versions (BDI-I and BDI-IA, the process of its adaptation to the Spanish population is described, the psychometric properties of this adaptation are summarized and its use in clinical practice is discussed. Concerning this use, guidelines and cut-off scores are proposed for measuring the severity of depression, evaluating the clinical significance of therapeutic change, screening for depression and assisting in the differential diagnosis of depressive disorders.

  4. Measurement invariance of the Beck Depression Inventory-Second Edition (BDI-II) across gender, race, and ethnicity in college students.

    Science.gov (United States)

    Whisman, Mark A; Judd, Charles M; Whiteford, Natalie T; Gelhorn, Heather L

    2013-08-01

    Measurement invariance of the Beck Depression Inventory-Second Edition (BDI-II) across gender, race, and ethnic groups was evaluated in a large sample of college students, using pooled data from 11 universities from diverse geographical regions in the United States (N = 7,369). Confirmatory factor analysis was used to test the fit of several possible factor structures, and the results from these analyses indicated that the BDI-II was most adequately represented by a hierarchical four-factor structure, composed of three first-order factors and one second-order factor. Results based on analyses of covariance structures indicated there was factorial invariance for this hierarchical four-factor structure across groups, suggesting that the BDI-II provides an assessment of severity of depressive symptoms that is equivalent across gender, race, and ethnicity in college students.

  5. Growth, nutritional status, and signs of rickets in 0-5-year-old children in a Kashin-Beck disease endemic area of Central Tibet.

    Science.gov (United States)

    Rooze, Shancy; Dramaix-Wilmet, Michèle; Mathieu, Françoise; Bally, Pascale; Yangzom, Dikki; Li, Jin Zhong; Goyens, Philippe

    2012-08-01

    In order to describe the growth of 0-5-year-old Tibetan children living in a Kashin-Beck disease (KBD) endemic rural area and to examine the relationship between anthropometric indicators and clinical signs of rickets, we analyzed the baseline data of a cohort of 668 children enrolled in a prospective program of calcium and vitamin D supplementation. Tibetan children suffer from growth retardation. Z score of weight-for-age, height-for-age, weight-for-height was below -2 in 32.5%, 27.7%, and 12.1% of the children, respectively. Clinical signs of severe rickets are highly prevalent. Underweight, stunting, and clinical rickets increases with age. Prevalence of malnutrition was higher in the presence of signs of rickets. The proportion of children with a head circumference Z score rickets were observed. Stunting and underweight are frequent and probably associated with rickets.

  6. Band gap characterization of ternary BBi1-xNx (0≤x≤1) alloys using modified Becke-Johnson (mBJ) potential

    Science.gov (United States)

    Yalcin, Battal G.

    2015-04-01

    The semi-local Becke-Johnson (BJ) exchange-correlation potential and its modified form proposed by Tran and Blaha have attracted a lot of interest recently because of the surprisingly accurate band gaps they can deliver for many semiconductors and insulators (e.g., sp semiconductors, noble-gas solids, and transition-metal oxides). The structural and electronic properties of ternary alloys BBi1-xNx (0≤x≤1) in zinc-blende phase have been reported in this study. The results of the studied binary compounds (BN and BBi) and ternary alloys BBi1-xNx structures are presented by means of density functional theory. The exchange and correlation effects are taken into account by using the generalized gradient approximation (GGA) functional of Wu and Cohen (WC) which is an improved form of the most popular Perdew-Burke-Ernzerhof (PBE). For electronic properties the modified Becke-Johnson (mBJ) potential, which is more accurate than standard semi-local LDA and PBE calculations, has been chosen. Geometric optimization has been implemented before the volume optimization calculations for all the studied alloys structure. The obtained equilibrium lattice constants of the studied binary compounds are in coincidence with experimental works. And, the variation of the lattice parameter of ternary alloys BBi1-xNx almost perfectly matches with Vegard's law. The spin-orbit interaction (SOI) has been also considered for structural and electronic calculations and the results are compared to those of non-SOI calculations.

  7. Susan G. Komen for the Cure

    Science.gov (United States)

    ... de sus senos:Consejos útiles para mujeres El Cancer de Mama y el Medio Ambiente: Preguntas y Respuestas Guía de herramientas de educación sobre el cancer de seno para comunidades hispanas/Latinas About Us ...

  8. Entretien avec Susan Holtz | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au seuil du prochain millénaire, le développement planétaire durable pose des défis complexes et d'envergure. Partout dans le monde, on cherche à relever ces défis en intégrant les politiques environnementales, sociales et économiques.

  9. Hiperbilirrubinemia neonatal prolongada devido à associação entre síndrome de Gilbert e doença hemolítica por incompatibilidade RhD Persistent neonatal hyperbilirubinemia resulting from Gilbert's syndrome in association with RhD hemolytic disease

    Directory of Open Access Journals (Sweden)

    Fernando P. Facchini

    2005-10-01

    Full Text Available OBJETIVO: Relatar associação infreqüente de patologia que cause aumento considerável de produção de bilirrubina e outra diminuição importante na sua excreção. DESCRIÇÃO: Mãe tercigesta, Rh negativo. Na primeira gestação, gerou recém-nascido normal, de termo, não tendo recebido imunoglobulina humana anti-RhD. A segunda gestação complicou-se por isoimunização Rh, dando à luz neonato de termo, o qual necessitou três exsanguinotransfusões e faleceu com 8 dias de vida. Na gestação atual, conseguiu dar à luz a termo recém-nascido tipo ORh positivo, Coombs direto positivo, bilirrubina de cordão 6,5 mg/dl e hematócrito 44%. Com 5 horas de vida, estava ictérico, tendo sido iniciados fenobarbital (por 3 dias e fototerapia intensiva. A hiperbilirrubinemia foi logo controlada, porém ascendia rapidamente sempre que a fototerapia era suspensa. No 10° dia de vida, a criança foi transfundida por anemia importante. Em vista da persistência da icterícia, no 13° dia de vida pensou-se em associação com síndrome de Gilbert, e o seqüenciamento de DNA foi solicitado. O resultado mostrou genótipo mutante homozigoto UDPT1A1[TA]7TAA. Permaneceu em fototerapia até o 17° dia de vida. Recebeu alta no dia seguinte, após controle de bilirrubinemia. Voltou para acompanhamento ambulatorial e apresentou desenvolvimentos pondo-estatural e neurológico normais. COMENTÁRIOS: O caso ressalta a importância da associação do aumento de produção/diminuição de excreção de bilirrubina na gênese de hiperbilirrubinemias prolongadas, intensas e passíveis de causar kernicterus, se não tratadas vigorosamente. Demonstra, ainda, a eficácia da fototerapia intensiva, reduzindo os riscos de tratamentos mais agressivos. Ressalta, também, a importância do acompanhamento das icterícias neonatais até a completa remissão dos sintomas.OBJECTIVE: To report on an infrequent association of pathologies causing considerable increase in bilirubin

  10. Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population.

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    Lulin Huang

    Full Text Available BACKGROUND: Kashin-Beck disease is a kind of degenerative osteoarthropathy. Genetic factors may play an important role in the pathogenesis of KBD. OBJECTIVE: To investigate the association of the selenoprotein genes GPX1 (rs1050450, rs1800668, and rs3811699, TrxR2 (rs5748469, and DIO2 (rs225014 with Kashin-Beck disease (KBD in a Tibetan population and to investigate the association of these SNPs with the serum iodine/selenium concentration in the Tibetan population. DESIGN: Five SNPs including rs1050450, rs1800668, and rs3811699 in the GPX1 gene, rs5748469 in the TrxR2 gene, and rs225014 in the DIO2 gene were analyzed in Tibetan KBD patients and controls using the SNaPshot method. P trend values of the SNPs were calculated using an additive model. RESULTS: None of the five SNPs in the three genes showed a significant association with KBD. Haplotypes TCC, TTC and TTT of rs1050450, rs1800668 and rs3811699 in GPX1 showed a significant association with KBD and controls with P value of 0.0421, 5.0E-4 and 0.0066, respectively. The GPX1 gene (rs1050450 showed a potential significant association with the iodine concentration in the Tibetan study population (P = 0.02726. However, no such association was detected with the selenium concentration (P = 0.2849. CONCLUSIONS: In this study, we showed that single SNPs in the genes GPX1 (rs1050450, rs1800668 and rs3811699, TrxR2 (rs5748469, and DIO2 (rs225014 may not be significantly associated with KBD in a Tibetan population. However, haplotype analysis of SNPs rs1050450, rs1800668 and rs3811699 in GPX1 gene showed a significant association with KBD. The results suggested that GPX1 gene play a protective role in the susceptivity of KBD in Tibetans. Furthermore, the GPX1 gene (rs1050450 may be significantly associated with the serum iodine concentration in Tibetans.

  11. Is the Beck Anxiety Inventory a good tool to assess the severity of anxiety? A primary care study in the Netherlands Study of Depression and Anxiety (NESDA).

    Science.gov (United States)

    Muntingh, Anna D T; van der Feltz-Cornelis, Christina M; van Marwijk, Harm W J; Spinhoven, Philip; Penninx, Brenda W J H; van Balkom, Anton J L M

    2011-07-04

    Appropriate management of anxiety disorders in primary care requires clinical assessment and monitoring of the severity of the anxiety. This study focuses on the Beck Anxiety Inventory (BAI) as a severity indicator for anxiety in primary care patients with different anxiety disorders (social phobia, panic disorder with or without agoraphobia, agoraphobia or generalized anxiety disorder), depressive disorders or no disorder (controls). Participants were 1601 primary care patients participating in the Netherlands Study of Depression and Anxiety (NESDA). Regression analyses were used to compare the mean BAI scores of the different diagnostic groups and to correct for age and gender. Patients with any anxiety disorder had a significantly higher mean score than the controls. A significantly higher score was found for patients with panic disorder and agoraphobia compared to patients with agoraphobia only or social phobia only. BAI scores in patients with an anxiety disorder with a co-morbid anxiety disorder and in patients with an anxiety disorder with a co-morbid depressive disorder were significantly higher than BAI scores in patients with an anxiety disorder alone or patients with a depressive disorder alone. Depressed and anxious patients did not differ significantly in their mean scores. The results suggest that the BAI may be used as a severity indicator of anxiety in primary care patients with different anxiety disorders. However, because the instrument seems to reflect the severity of depression as well, it is not a suitable instrument to discriminate between anxiety and depression in a primary care population.

  12. Near-edge band structures and band gaps of Cu-based semiconductors predicted by the modified Becke-Johnson potential plus an on-site Coulomb U

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yubo; Zhang, Jiawei; Wang, Youwei [State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China); Gao, Weiwei; Abtew, Tesfaye A. [Department of Physics, University at Buffalo, SUNY, Buffalo, New York 14260 (United States); Zhang, Peihong, E-mail: pzhang3@buffalo.edu, E-mail: wqzhang@mail.sic.ac.cn [Department of Physics, University at Buffalo, SUNY, Buffalo, New York 14260 (United States); Beijing Computational Science Research Center, Beijing 100084 (China); Zhang, Wenqing, E-mail: pzhang3@buffalo.edu, E-mail: wqzhang@mail.sic.ac.cn [State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China); School of Chemistry and Chemical Engineering and Sate Key Laboratory of Coordination Chemistry, Nanjing University, Jiangsu 210093 (China)

    2013-11-14

    Diamond-like Cu-based multinary semiconductors are a rich family of materials that hold promise in a wide range of applications. Unfortunately, accurate theoretical understanding of the electronic properties of these materials is hindered by the involvement of Cu d electrons. Density functional theory (DFT) based calculations using the local density approximation or generalized gradient approximation often give qualitative wrong electronic properties of these materials, especially for narrow-gap systems. The modified Becke-Johnson (mBJ) method has been shown to be a promising alternative to more elaborate theory such as the GW approximation for fast materials screening and predictions. However, straightforward applications of the mBJ method to these materials still encounter significant difficulties because of the insufficient treatment of the localized d electrons. We show that combining the promise of mBJ potential and the spirit of the well-established DFT + U method leads to a much improved description of the electronic structures, including the most challenging narrow-gap systems. A survey of the band gaps of about 20 Cu-based semiconductors calculated using the mBJ + U method shows that the results agree with reliable values to within ±0.2 eV.

  13. First-principles energy band calculation of Ruddlesden-Popper compound Sr3Sn2O7 using modified Becke-Johnson exchange potential

    Science.gov (United States)

    Kamimura, Sunao; Obukuro, Yuki; Matsushima, Shigenori; Nakamura, Hiroyuki; Arai, Masao; Xu, Chao-Nan

    2015-12-01

    The electronic structure of Sr3Sn2O7 is evaluated by the scalar-relativistic full potential linearized augmented plane wave (FLAPW+lo) method using the modified Becke-Johnson potential (Tran-Blaha potential) combined with the local density approximation correlation (MBJ-LDA). The fundamental gap between the valence band (VB) and conduction band (CB) is estimated to be 3.96 eV, which is close to the experimental value. Sn 5s states and Sr 4d states are predominant in the lower and upper CB, respectively. On the other hand, the lower VB is mainly composed of Sn 5s, 5p, and O 2p states, while the upper VB mainly consists of O 2p states. These features of the DOS are well reflected by the optical transition between the upper VB and lower CB, as seen in the energy dependence of the dielectric function. Furthermore, the absorption coefficient estimated from the MBJ-LDA is similar to the experimental result.

  14. Psychometric properties and correlates of the beck hopelessness scale in family caregivers of Nigerian patients with psychiatric disorders in Southwestern Nigeria

    Directory of Open Access Journals (Sweden)

    Olutayo Aloba

    2016-01-01

    Full Text Available Objectives: To examine the construct and correlates of hopelessness among family caregivers of Nigerian psychiatric patients. Materials and Methods: This is a cross-sectional, descriptive study involving 264 family caregiver-patients' dyads recruited from two university teaching hospitals psychiatric clinics in Southwestern Nigeria. Results: Exploratory factor analysis revealed a two-factor 9-item model of the Beck Hopelessness Scale (BHS among the family caregivers. Confirmatory factor analysis of the model revealed satisfactory indices of fitness (goodness of fit index = 0.97, comparative fit index = 0.96, Chi-square/degree of freedom (CMIN/DF = 1.60, root mean square error of approximation = 0.048, expected cross-validation index = 0.307, and standardized root mean residual = 0.005. Reliability of the scale was modestly satisfactory (Cronbach's alpha 0.72. Construct validity of scale was supported by significant correlations with the family caregivers' scores on the Zarit Burden Interview, mini international neuropsychiatric interview suicidality module, General Health Questionnaire-12 (GHQ-12, and Patient Health Questionnaire-9. The greatest variance in the family caregivers' scores on the BHS was contributed by their scores on the psychological distress scale (GHQ-12. Conclusions: The BHS has adequate psychometric properties among Nigerian psychiatric patients' family caregivers. There is the need to pay attention to the psychological well-being of the family caregivers of Nigerian psychiatric patients.

  15. Psychometric properties of the Portuguese version of the State-Trait Anxiety Inventory applied to college students: factor analysis and relation to the Beck Depression Inventory

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    L. Andrade

    2001-03-01

    Full Text Available The psychometric properties of the Portuguese version of the trait form of the State-Trait Anxiety Inventory (STAI-T and its relation to the Beck Depression Inventory (BDI were evaluated in a large Brazilian college student sample containing 845 women and 235 men. STAI-T scores tended to be higher for women, singles, those who work, and subjects under 30 years. Factor analysis of the STAI-T for total sample and by gender yielded two factors: the first representing a mood dimension and the second being related to worrying or cognitive aspects of anxiety. In order to study the relation between anxiety and depression measures, factor analysis of the combination of the 21 BDI items and the 20 STAI-T items was also carried out. The analysis resulted in two factors that were analyzed according to the tripartite model of anxiety and depression. Most of the BDI items (measuring positive affectivity and nonspecific symptoms of depression were loaded on the first factor and four STAI-T items that measure positive affectivity. The remaining STAI-T items, all of them measuring negative affect, remained in the second factor. Thus, factor 1 represents a depression dimension and factor 2 measures a mood-worrying dimension. The findings of this study suggest that, although widely used as an anxiety scale, the STAI-T in fact measures mainly a general negative affect.

  16. Calibration of response and remission cut-points on the Beck Depression Inventory-Second Edition for monitoring seasonal affective disorder treatment outcomes.

    Science.gov (United States)

    Reeves, Gloria M; Rohan, Kelly J; Langenberg, Patricia; Snitker, Soren; Postolache, Teodor T

    2012-04-01

    The purpose of this study is to define treatment response and remission cut-point scores for the Beck Depression Inventory-Second Edition (BDI-II) when used to monitor seasonal affective disorder (SAD) treatment. Data from two published randomized clinical trials for SAD were utilized to complete a ROC analysis to define response and remission thresholds for the BDI-II. The Structured Interview Guide for the Hamilton Rating Scale for Depression-Seasonal Affective Disorder Version (SIGH-SAD) was used as a reference standard. Data from the two trials included BDI-II and SIGH-SAD scores for patients at baseline, 6 weeks (post-treatment), and 1 year (next winter). BDI-II score of ≤ 9 was the derived criterion for remission of SAD, and BDI-II score decrease of 50% from baseline was the criterion for treatment response. Study participants were primarily female (94%) and Caucasian (80%) so demographic diversity of the sample was limited. This study validated BDI-II scores compared to the SIGH-SAD reference standard. The BDI-II has greater potential for widespread use by clinicians than the SIGH-SAD to monitor SAD patients because it is a brief self-report instrument that can be conveniently administered in the waiting room. Copyright © 2011 Elsevier B.V. All rights reserved.

  17. What does the beck depression inventory measure in myocardial infarction patients? a psychometric approach using item response theory and person-fit.

    Science.gov (United States)

    Wardenaar, Klaas J; Wanders, Rob B K; Roest, Annelieke M; Meijer, Rob R; De Jonge, Peter

    2015-06-01

    Observed associations between depression following myocardial infarction (MI) and adverse cardiac outcomes could be overestimated due to patients' tendency to over report somatic depressive symptoms. This study was aimed to investigate this issue with modern psychometrics, using item response theory (IRT) and person-fit statistics to investigate if the Beck Depression Inventory (BDI) measures depression or something else among MI-patients. An IRT-model was fit to BDI-data of 1135 MI patients. Patients' adherence to this IRT-model was investigated with person-fit statistics. Subgroups of "atypical" (low person-fit) and "prototypical" (high person-fit) responders were identified and compared in terms of item-response patterns, psychiatric diagnoses, socio-demographics and somatic factors. In the IRT model, somatic items had lower thresholds compared to depressive mood/cognition items. Empirically identified "atypical" responders (n = 113) had more depressive mood/cognitions, scored lower on somatic items and more often had a Comprehensive International Diagnostic Interview (CIDI) depressive diagnosis than "prototypical" responders (n = 147). Additionally, "atypical" responders were younger and more likely to smoke. In conclusion, the BDI measures somatic symptoms in most MI patients, but measures depression in a subgroup of patients with atypical response patterns. The presented approach to account for interpersonal differences in item responding could help improve the validity of depression assessments in somatic patients. Copyright © 2015 John Wiley & Sons, Ltd.

  18. Pretreatment Beck Depression Inventory score is an important predictor for Post-treatment score in infertile patients: a before-after study

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    Ramezanzadeh Fatemeh

    2005-05-01

    Full Text Available Abstract Background The experience of infertility can be extremely stressful. Some of the risk factors for depression in infertility are being female, repeated unsuccessful treatment cycles or a 2 to 3 year history of infertility, low socioeconomic status, foreign nationality, lack of partner support, life events and previous depression. In this study, we analyzed the Beck Depression Inventory score at the beginning and the end of infertility treatment, to determine which factors may influence the BDI score after treatment of infertility. Methods In a before-after study, in a university-affiliated teaching hospital, 251 women who had been visited for assisted reproductive technology infertility treatment participated in the study. BDI score was assessed before and after treatment of infertility. Results The mean BDI score rose after unsuccessful treatment and dropped after successful treatment. Those with lower education levels had a higher BDI score before treatment. BDI score after treatment was positively correlated with pretreatment BDI scoreand duration of infertility. Conclusion BDI score after treatment was strongly connected to the BDI score before treatment, the result of therapy and to the duration of infertility. The influence of duration of infertility on BDI score after treatment of infertility is weak. So a simple method to screen patients at risk of depression after infertility treatment is determining pretreatment BDI score and predicting the result of infertility treatment by other risk factors.

  19. Validity of the Hospital Anxiety and Depression Scale and the Beck Depression Inventory for use in end-stage renal disease patients.

    Science.gov (United States)

    Loosman, W L; Siegert, C E H; Korzec, A; Honig, A

    2010-11-01

    To validate the Hospital Anxiety and Depression Scale (HADS) and the Beck Depression Inventory (BDI) for use in patients with end-stage renal disease (ESRD) and to compare the outcome of both screening measures with each other. Cross-sectional and between-subjects design. The independent variable was the diagnosis depression by the Mini International Neuropsychiatric Interview (MINI). The dependent variables were the HADS and BDI total score. All 130 patients with ESRD who were treated with haemodialysis (HD) or peritoneal dialyses in the Sint Lucas Andreas Hospital in Amsterdam were eligible for this study and were asked to fill out both HADS and BDI. The outcomes of both rating scales were compared with the diagnosis major depressive episode based on the MINI, which was seen as the gold standard. Receiver operating characteristic curves were used to choose optimal cut-off values. Of 62 enrolled subjects, 21 (34%) were diagnosed with a depressive disorder. Optimal cut-off values were ≥12 (HADS) and ≥13 (BDI). Sensitivity was 81.0% (HADS) and 75.0% (BDI). Specificity was 90.2% for both. Both HADS and BDI are valid screening instruments for the diagnosis depression in ESRD patients but there is no statistical difference found between both rating scales.

  20. Sensitivity to detect change and the correlation of clinical factors with the Hamilton Depression Rating Scale and the Beck Depression Inventory in depressed inpatients.

    Science.gov (United States)

    Schneibel, Rebecca; Brakemeier, Eva-Lotta; Wilbertz, Gregor; Dykierek, Petra; Zobel, Ingo; Schramm, Elisabeth

    2012-06-30

    Discrepancies between scores on the Hamilton Depression Rating Scale (HAMD) and the Beck Depression Inventory (BDI), as well as differences regarding their sensitivity to detect change, have been reported. This study investigates discrepancies and their potential prediction on the basis of demographic, personality, and clinical factors in depressed inpatients and analyzes the sensitivity to change. The HAMD and the BDI were administered to 105 inpatients with major depressive disorder randomized to 5 weeks of either interpersonal psychotherapy or clinical management. Personality was assessed with the NEO Five-Factor Inventory. Low extraversion and high neuroticism were associated with relatively higher endorsement of depressive symptoms on the BDI compared with the HAMD. The HAMD presented a greater reduction of symptom scores than the BDI. Patients with high BDI scores, high HAMD scores or both revealed the greatest change, possibly due to a statistical effect of regression to the mean. Restricted by sample size, analyses were not differentiated by treatment condition. Regression to the mean cannot be tested directly, but it might be considered as a possible explanation. The HAMD and the BDI should be regarded as two complementary rather than redundant or competing instruments as the discrepancy is associated with personality characteristics. Attributing large effect sizes solely to effective treatment and a sensitive measure may be misleading. Copyright © 2012 Elsevier Ltd. All rights reserved.

  1. [Assessment of severity of depressive symptoms using the Polish version IA of Beck Depression Inventory in healthy men, inhabitants of Wrocław].

    Science.gov (United States)

    Lopuszańska, Monika; Szklarska, Alicja; Jankowska, Ewa A

    2013-01-01

    Aging is accompanied by progression of depressive symptoms, which significantly impair the prognosis and quality of life of elderly men. Currently, there are no Polish reference values reflecting age-related changes in the intensity of depressive symptoms in healthy men. An assessment of the severity of depressive symptoms in a population of healthy Polish men, and an evaluation of the effects of age and education on the analyzed variables. We examined 341 healthy men, inhabitants of Wroclaw, aged 32-79, without any significant medical history. The intensity of depressive symptoms was assessed using the Polish version IA of Beck Depression Inventory (BDI). We observed an increase in the severity of depressive symptoms in the subsequent age categories in the examined men, in all the analyzed symptoms (32-45, 46-55, 56-65, 66-79 years--4.1 +/- 4.4, 8.2 +/- 4.2, 10.4+/- 3.6, 13.4 +/- 3.4 points, respectively, r = 0.65, p or = 10 and depression (BDI > or = 20 and depressive symptoms in the examined men (p > 0.2). In Poland, male aging is accompanied by an increase in the severity of depressive symptoms. Age, but not education, constitutes a major determinant of these symptoms. The presented data may be used as reference values for BDI scores of healthy Polish men in subsequent age categories.

  2. Fulvic acid supplementation and selenium deficiency disturb the structural integrity of mouse skeletal tissue. An animal model to study the molecular defects of Kashin-Beck disease.

    Science.gov (United States)

    Yang, C; Niu, C; Bodo, M; Gabriel, E; Notbohm, H; Wolf, E; Müller, P K

    1993-01-01

    High concentrations of fulvic acid and selenium deficiency are the main causative factors of Kashin-Beck disease, an endemic, chronic and degenerative osteoarticular disorder found in China. In the search for an animal model of this disease, mice were exposed to these pathogenetic conditions for two generations and the collagen types from skin, bone and cartilage were analysed. The growth of the treated mice was slightly retarded, and the rate of reproduction was lower in animals maintained on a fulvic acid-supplemented and/or selenium-deficient diet. Irregular bone formation was seen by radiography and morphometry. Biochemical analysis indicated that lysine residues in collagen I from bone and in collagen II from cartilage were overmodified. The values of Hyl/(Hyl+Lys) in bone collagen alpha 1(I) chains from treated mice were about 0.434-0.484, i.e. substantially higher than that of the control (0.277). The values of this parameter for collagen II were 0.482 for control and 0.546-0.566 for treated mice. The melting temperature of collagen I from bones of treated mice was 1 degrees C lower than that of control collagen, indicating decreased thermal stability. The breakage point of the tibiae of treated mice occurred at a lower preload force than for controls, suggesting that the overmodified and thermally less stable collagen molecules are causally related to a lower mechanical strength of bones. Images Figure 1 Figure 2 Figure 3 PMID:8435081

  3. Opto-electronic response of spinels MgAl2O4 and MgGa2O4 through modified Becke-Johnson exchange potential

    Science.gov (United States)

    Amin, B.; Khenata, R.; Bouhemadou, A.; Ahmad, Iftikhar; Maqbool, M.

    2012-07-01

    A first-principles technique capable of describing the state accurately near to excited states of semiconductors and insulators, namely the modified Becke-Johnson (mBJ) exchange potential approximation is used to investigate the opto-electronic response of magnesium spinel oxides: MgAl2O4 and MgGa2O4. The predicted bandgaps using the mBJ exchange approximation show a significant improvement over previous theoretical work using the common LDA and GGA, and are very closer to the experimental results. Band gap dependent optical parameters, like dielectric constant, index of refraction, reflectivity and optical conductivity are calculated and analyzed. The static dielectric constant and refractive index of MgGa2O4 are much larger than that of MgAl2O4. Refractive index drops below unity for higher energy photons, higher than 17 eV, show that the velocities of incident photons are greater than the velocity of light. However, these overlook can be explained by the fact that a signal must be transmitted as a wave packet rather than monochromatic wave. Moreover, the peak positions of the calculated optical parameters move down to low energies when the value of the band gap decreases. This comprehensive theoretical study of the optoelectronic properties predicts that these materials can be effectively used in the optical devices working in major part of the spectrum.

  4. Near-edge band structures and band gaps of Cu-based semiconductors predicted by the modified Becke-Johnson potential plus an on-site Coulomb U.

    Science.gov (United States)

    Zhang, Yubo; Zhang, Jiawei; Gao, Weiwei; Abtew, Tesfaye A; Wang, Youwei; Zhang, Peihong; Zhang, Wenqing

    2013-11-14

    Diamond-like Cu-based multinary semiconductors are a rich family of materials that hold promise in a wide range of applications. Unfortunately, accurate theoretical understanding of the electronic properties of these materials is hindered by the involvement of Cu d electrons. Density functional theory (DFT) based calculations using the local density approximation or generalized gradient approximation often give qualitative wrong electronic properties of these materials, especially for narrow-gap systems. The modified Becke-Johnson (mBJ) method has been shown to be a promising alternative to more elaborate theory such as the GW approximation for fast materials screening and predictions. However, straightforward applications of the mBJ method to these materials still encounter significant difficulties because of the insufficient treatment of the localized d electrons. We show that combining the promise of mBJ potential and the spirit of the well-established DFT + U method leads to a much improved description of the electronic structures, including the most challenging narrow-gap systems. A survey of the band gaps of about 20 Cu-based semiconductors calculated using the mBJ + U method shows that the results agree with reliable values to within ±0.2 eV.

  5. Prevalence of depression and its associated factors using Beck Depression Inventory among students of School of Health and Nutrition, Tabriz, Iran in 2009

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    Saeid Safiri

    2013-12-01

    Full Text Available BACKGROUND: Depression is a debilitating disease which is caused by social and environmental factors in additionto genetic factors. University students are among the young and vulnerable population to depression and theirpopulation is increasing with increase in universities and higher education institutions. Therefore, any disturbance instudent's mental and physical health is a serious threat for the next generation. In this study, we aimed to estimate theprevalence of depression and its related factors in students of School of Health and Nutrition at Tabriz University ofMedical Sciences, Iran. METHODS: This was a cross-sectional survey on 175 students selected by stratified random sampling, educating indifferent fields at School of Health and Nutrition in 2009. The data collection tool was the short form of the standardBeck Depression Inventory (BDI which is used for screening depression. The collected data were analyzed by softwareStata Statistical Software, Release 10.0 (Stata Corporation, College Station, TX, USA. RESULTS: The results showed that 62.7% of the students had depression and from these 10.9% suffered from severedepression. Significantly higher depression rates were seen in students with worrisome about the future. Marriedstudents, those interested in their field of study, those performing prayers and regularly reading the Quran hadsignificantly lower rates of depression. CONCLUSIONS: Due to the high prevalence of depression, screening strategies should be implemented to identifydepressed students. Counseling services should be available and accessible to students at risk.

  6. Genome-wide gene expression analysis suggests an important role of hypoxia in the pathogenesis of endemic osteochondropathy Kashin-Beck disease.

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    Feng Zhang

    Full Text Available Kashin-Beck Disease (KBD is an endemic osteochondropathy, the pathogenesis of which remains unclear now. In this study, we compared gene expression profiles of articular cartilage derived respectively from KBD patients and normal controls. Total RNA were isolated, amplified, labeled and hybridized to Agilent human 1A 22 k whole genome microarray chip. qRT-PCR was conducted to validate our microarray data. We detected 57 up-regulated genes (ratios ≥2.0 and 24 down-regulated genes (ratios ≤0.5 in KBD cartilage. To further identify the key genes involved in the pathogenesis of KBD, Bayesian analysis of variance for microarrays (BAM software was applied and identified 12 potential key genes with an average ratio 6.64, involved in apoptosis, metabolism, cytokine & growth factor and cytoskeleton & cell movement. Gene Set Enrichment Analysis (GSEA software was used to identify differently expressed gene ontology categories and pathways. GSEA found that a set of apoptosis, hypoxia and mitochondrial function related gene ontology categories and pathways were significantly up-regulated in KBD compared to normal controls. Based on the results of this study, we suggest that chronic hypoxia-induced mitochondrial damage and apoptosis might play an important role in the pathogenesis of KBD. Our efforts may help to understand the pathogenesis of KBD as well as other osteoarthrosis with similar articular cartilage lesions.

  7. Rediscovery of Sagittalarva inornata n. gen., n. comb. (Gilbert, 1890) (Perciformes: Labridae), a long-lost deepwater fish from the eastern Pacific Ocean: a case study of a forensic approach to taxonomy using DNA barcoding.

    Science.gov (United States)

    Victor, Benjamin C; Alfaro, Michael E; Sorenson, Laurie

    2013-01-01

    Some of the more valuable contributions of a standardized DNA sequence database (the DNA barcode) are matching specimens of different life stages and confirming the species identity of individuals from distant locations. These applications can facilitate the detective work required to solve difficult taxonomic problems. In this case, a match was made between the COI mtDNA sequence of an adult male wrasse recently caught at the tip of Baja California in Mexico in deep water (30-100m) and sequences from a series of unusual larvae collected about 3500 km to the south, in the open ocean over the Galápagos Rift hydrothermal vents in 1985. The Baja adults fit the recent description of Halichoeres raisneri Baldwin & McCosker, 2001 from the Galápagos and Cocos Islands. However, another deepwater labrid is known from the same site and depth in Baja; it is the type locality for the century-old holotype and only specimen of the Cape Wrasse Pseudojulis inornatus Gilbert, 1890 (later as Pseudojuloides inornatus). Deepwater video images from the tip of Baja show wrasses identical to H. raisneri photographed in Galápagos but who also fit the description of Pseudojulis inornatus. This coincidence led to a closer investigation of the holotype with x-ray, which revealed unanticipated caniniform teeth (vs. incisiform in Pseudojuloides) and an error in the fin-ray count in the original description, both of which mistakenly separated Halichoeres raisneri. The two species now match in markings, meristics, and morphology as well as overlapping range and are therefore synonymized. Phenetic and phylogenetic trees using mtDNA and nuclear DNA sequences show the species is not close to any other lineage and does not group with the other julidine labrids of the New World or the Pseudojuloides or Halichoeres of the Indo-Pacific. The distinctive larval morphology, long, thin, and flattened with a sharply pointed black-tipped snout, resembles no other described labrid larvae and, without an

  8. En kommentar til Becks model

    DEFF Research Database (Denmark)

    Philipps, Morten; Andersen, Thomas Dyreborg

    2014-01-01

    Flipped classroom – en trend vi må forholde os til Online læringsressourcer har de sidste par år fået mange til at indse at teknologien har noget radikalt andet at byde på, og dette har skabt en populær didaktik kaldet flipped classroom som vi både ser vinde indpas i folkeskolen og på...... Professionshøjskolen Metropol hvor vi er ansat. Kommentaren her retter sig mod en tidligere bragt artikel i MONA, “Det virtuelle læringsrums topologi” af Claus Jessen. Vi argumenterer for at den didaktiske model flipped classrooms brug af video, frem for tavleundervisning, kan frigøre undervisningstid til at arbejde...

  9. Kriisi fataalne oht / Ulrich Beck

    Index Scriptorium Estoniae

    Beck, Ulrich

    2009-01-01

    Sotsioloogi arvates peitub praeguses majanduskriisis võimalus tuua Euroopa Liit uutele alustele, võttes aluseks printsiibi, et poliitika on rahvuslikul tasemel seda edukam, mida euroopalikum, kosmopoliitlikum ta on

  10. Anxiety rating scales in Parkinson's disease: a validation study of the Hamilton anxiety rating scale, the Beck anxiety inventory, and the hospital anxiety and depression scale.

    Science.gov (United States)

    Leentjens, Albert F G; Dujardin, Kathy; Marsh, Laura; Richard, Irene H; Starkstein, Sergio E; Martinez-Martin, Pablo

    2011-02-15

    Anxiety is a prevalent and disabling condition in Parkinson's disease (PD). The lack of anxiety rating scales validated for this population hampers research into anxiety in PD. The aim of this study is to assess the clinimetric properties of the Hamilton anxiety rating scale (HARS), the Beck anxiety inventory (BAI), and the hospital anxiety and depression scale (HADS) in PD patients. Three hundred forty-two PD patients underwent a standardized assessment including a structured interview for diagnostic and statistical manual diagnoses of anxiety disorders and completion of the HARS, BAI, and HADS. Inter-rater reliability of the HARS was assessed in 60 patients; test-retest reliability of the BAI and HADS in 213 and 217 patients, respectively. Thirty-four percent of patients suffered from an anxiety disorder, whereas an additional 11.4% had clinically significant anxiety symptoms in the absence of a diagnosis of anxiety disorder. Acceptability, score distribution, and known groups validity over different levels of anxiety were adequate. Inter-rater reliability for the HARS and test-retest reliability for the BAI and HADS were good. The HARS, but not the BAI and HADS, had a satisfactory inter-item correlation, convergent validity and factorial structure. For all scales, the positive predictive value was poor, and the negative predictive value was moderate. Given the adequate known groups validity of all three rating scales, each of these scales is likely to be useful in clinical practice or research for evaluation of symptom severity. Limitations in the construct validity of the anxiety scales in this study raise questions regarding suitability for their use in PD. Copyright © 2011 Movement Disorder Society.

  11. Combination use of Beck Depression Inventory and two-question case-finding instrument as a screening tool for depression in the workplace

    Science.gov (United States)

    Adachi, Yasunori; Nobata, Ryoko; Suzuki, Tatsuyo; Yoshida, Keizo; Ono, Yuichiro; Ozaki, Norio

    2012-01-01

    Objectives The present study aimed to validate screening tools that could be used to identify depression among workers. Design Diagnostic test study. Settings Workers from three Japanese companies agreed to participate. Participants Recruitment for the group 1 occurred between January 2001 and February 2004, and 89 participants (81 men and 8 women with a mean age of 38.4±6.6 years) (98.8%) took part in the study. Recruitment for the group 2 occurred between July 2000 and February 2004, and 1500 participants (1408 men and 92 women with a mean age of 40.9±7.2 years) (94.2%) took part in the study. Demographic data are shown in supplementary table 1. Interventions Primary and secondary outcome measures: the Beck Depression Inventory (BDI) and a two-question case-finding instrument (TQI) were administered to 89 workers and Mini-International Neuropsychiatric Interview was conducted to verify the diagnosis of depression. A second group of 1500 workers completed the BDI and TQI to detect possible sample bias for the distribution of depression. Specificity, sensitivity and positive predictive value were calculated in order to obtain the optimal cut-off scores for BDI and TQI and receiver operating characteristic curves, and Youden Index were applied to further refine the optimal cut-off scores. Results When paired together, BDI score ≥10 and TQI score of 2 adequately identified workers who had major depressive disorder and those who had other psychiatric disorders that are frequently comorbid with major depressive disorder. Conclusions The combination of BDI score ≥10 and TQI score of 2 can adequately screen for current and potential cases of depression among workers. Furthermore, BDI and TQI offer the advantage of being relatively easy to administer to a large number of workers. Early detection of depression could improve treatment outcomes and decrease economic burden. Trail registration PMID:22566608

  12. Phylogeography of Beck's Desert Scorpion, Paruroctonus becki, reveals Pliocene diversification in the Eastern California Shear Zone and postglacial expansion in the Great Basin Desert.

    Science.gov (United States)

    Graham, Matthew R; Jaeger, Jef R; Prendini, Lorenzo; Riddle, Brett R

    2013-12-01

    The distribution of Beck's Desert Scorpion, Paruroctonus becki (Gertsch and Allred, 1965), spans the 'warm' Mojave Desert and the western portion of the 'cold' Great Basin Desert. We used genetic analyses and species distribution modeling to test whether P. becki persisted in the Great Basin Desert during the Last Glacial Maximum (LGM), or colonized the area as glacial conditions retreated and the climate warmed. Phylogenetic and network analyses of mitochondrial cytochrome c oxidase 1 (cox1), 16S rDNA, and nuclear internal transcribed spacer (ITS-2) DNA sequences uncovered five geographically-structured groups in P. becki with varying degrees of statistical support. Molecular clock estimates and the geographical arrangement of three of the groups suggested that Pliocene geological events in the tectonically dynamic Eastern California Shear Zone may have driven diversification by vicariance. Diversification was estimated to have continued through the Pleistocene, during which a group endemic to the western Great Basin diverged from a related group in the eastern Mojave Desert and western Colorado Plateau. Demographic and network analyses suggested that P. becki underwent a recent expansion in the Great Basin. According to a landscape interpolation of genetic distances, this expansion appears to have occurred from the northwest, implying that P. becki may have persisted in part of the Great Basin during the LGM. This prediction is supported by species distribution models which suggest that climate was unsuitable throughout most of the Great Basin during the LGM, but that small patches of suitable climate may have remained in areas of the Lahontan Trough. Published by Elsevier Inc.

  13. Rendimiento diagnóstico y estructura factorial del Inventario de Depresión de Beck-II (BDI-II

    Directory of Open Access Journals (Sweden)

    Jesús Sanz

    2013-01-01

    Full Text Available Este estudio tenía dos objetivos. Primero, analizar el rendimiento diagnóstico de la versión española del Inventario de Depresión de Beck-II (BDI-II en una muestra de pacientes con trastornos psicológicos y, segundo, examinar si las soluciones unifactoriales y bifactoriales del BDI-II encontradas previamente en muestras similares son replicables y, de ser así, analizar la contribución relativa del factor general y de los dos factores específicos a la varianza del BDI-II. El BDI-II, junto con el módulo de los trastornos del estado de ánimo de la Entrevista Clínica Estructurada para los Trastornos del Eje I del DSM-IV (SCID-I VC y un listado de cotejo de síntomas depresivos completado por el clínico, fueron aplicados a una muestra española de 322 pacientes adultos ambulatorios con diversos trastornos psicológicos. Tomando como criterio el diagnóstico clínico basado en la SCID-I VC y el listado de cotejo de síntomas depresivos, el BDI-II demostró un rendimiento diagnóstico aceptable para discriminar entre pacientes con trastorno depresivo mayor y pacientes sin depresión. Los análisis factoriales indicaron que el BDI-II mide una dimensión general de depresión compuesta por dos factores relacionados (somático y cognitivo, pero estos factores apenas explicaban varianza adicional más allá de la puntuación global.

  14. [Reliability and Validity of Function Score for Adult Tibetans with Kashin Beck Disease in Aba Tibetan Autonomous Area in Sichuan Province].

    Science.gov (United States)

    Huang, Qiang; Zhou, Zong-ke; Ma, Jun; Shen, Bin; Kang, Peng-de; Yang, Jing; Pei, Fu-xing

    2015-11-01

    To validate the function score for adult Tibetans with Kashin-Beck disease (FSAT- KBD) measuring daily life and work functional status of KBD patients. From September to October 2010, 352 adult KBD patients in Rangtang County of Aba Tibetan autonomous region were invited to complete FSAT-KBD. The internal consistency of FSAT-KBD was assessed using Cronbach's alpha coefficients. Principal component analysis with varimax rotation was performed to explore factor structure of the instrument, with item-domain correlations being examined using Spearman's rank correlation tests. Discriminant validity of the FSAT-KBD was assessed by comparing scores of the respondents with different ages and different functional status. Convergent validity of the FSAT-KBD was assessed through a comparison with the medical outcomes study short form health survey (SF-12) and visual analogue scale (VAS). 338 KBD patients (a response rate of 96.0%) completed the questionnaire in an average of (3.2 +/- 1.6) min. The instrument achieved a Cronbach's alpha of 0.945, with item-to-domain correlations exceeding 0.0. Two latent factors were extracted, which explained 72.8% of the total variance. The factor structure fitted well with our conceptual hypothesis. Respondents with different age, duration of suffering and number of affected joints had different FSAT-KBD scores. The FSAT-KBD results were correlated with those of SF-12 and VAS. FSAT-KBD is a reliable and valid instrument for measuring daily functional status of adult KBD patients in Aba Tibetan autonomous area in China.

  15. Trace Element Levels in Scalp Hair of School Children in Shigatse, Tibet, an Endemic Area for Kaschin-Beck Disease (KBD).

    Science.gov (United States)

    Guo, Ya'nan; Li, Hairong; Yang, Linsheng; Li, Yonghua; Wei, Binggan; Wang, Wuyi; Gong, Hongqiang; Guo, Min; Nima, Cangjue; Zhao, Shengcheng; Wang, Jing

    2017-11-01

    Kaschin-Beck disease (KBD) is an endemic osteoarthritis, and the etiology is closely related with levels of trace elements in the human body. Currently, it is clear that the selenium (Se) status of children in KBD areas is lower than that in non-KBD areas in the Tibetan Plateau, whereas role of other elements are yet unknown. This study aimed to assess some essential trace elements (Se, Mo, Mn, Zn, Fe, Cu, Co, and Sr) in children using scalp hair as a biomarker, and 157 samples from school children aged 8-14 years old were collected from both KBD and non-KBD areas in Shigatse, Tibet. Se and Mo were measured by inductive coupled plasma mass spectrometry, and the other elements were determined by inductive coupled plasma optical emission spectrometry. Compared with the non-KBD areas, Se, Mo, Mn, Fe, Zn, Co, and Sr levels of children in KBD areas were found to be significantly different (P 115 to 0.299 mg/kg, while in non-KBD areas it ranged from 0.135 to 0.519 mg/kg. The Zn content of children's hair was between 83 and 207 mg/kg in KBD areas, while it was 37 and 219 mg/kg in non-KBD areas. Lower Se and higher Zn levels in children in KBD areas was found when compared with non-KBD groups. In addition, Mo levels were found to be different between KBD areas and non-KBD areas on the opposite side of the Yarlung Zangbo River, but no close relationship was shown because there was no difference compared with the non-KBD area on the same side of the river. Our observations suggest that Se deficiency is still an important factor for the occurrence and prevalence of KBD, while the relationship between Zn and KBD needs to be further explored in the Tibetan Plateau.

  16. Adaptation and Latent Structure of the Swahili Version of Beck Depression Inventory-II in a Low Literacy Population in the Context of HIV.

    Directory of Open Access Journals (Sweden)

    Amina Abubakar

    Full Text Available We set out to adapt the Beck Depression Inventory (BDI-II in Kenya and examine its factorial structure.In the first phase we carried out in-depth interviews involving 29 adult members of the community to elicit their understanding of depression and identify aspects of the BDI-II that required adaptation. In the second phase, a modified version of BDI-II was administered to 221 adults randomly selected from the community to allow for the evaluation of its psychometric properties. In the third phase of the study we evaluated the discriminative validity of BDI-11 by comparing a randomly chosen community sample (n = 29 with caregivers of adolescents affected by HIV (n = 77.A considerable overlap between the BDI symptoms and those generated in the interviews was observed. Relevant idioms and symptoms such as 'thinking too much' and 'Kuchoka moyo (having a tired heart' were identified. The administration of the BDI had to be modified to make it suitable for the low literacy levels of our participants. Fit indices for several models (one factorial, two-factor model and a three factor model were all within acceptable range. Evidence indicated that while multidimensional models could be fitted, the strong correlations between the factors implied that a single factor model may be the best suited solution (alpha [0.89], and a significant correlation with locally identified items [r = 0.51] confirmed the good psychometric properties of the adapted BDI-II. No evidence was found to support the hypothesis that somatization was more prevalent. Lastly, caregivers of HIV affected adolescents had significantly higher scores compared to adults randomly selected from the community F(1, 121 = 23.31, p < .001 indicating the discriminative validity of the adapted BDI = II.With an adapted administration procedure, the BDI-II provides an adequate measure of depressive symptoms which can be used alongside other measures for proper diagnosis in a low literacy population.

  17. Is the beck anxiety inventory a good tool to assess the severity of anxiety? A primary care study in The Netherlands study of depression and anxiety (NESDA

    Directory of Open Access Journals (Sweden)

    van der Feltz-Cornelis Christina M

    2011-07-01

    Full Text Available Abstract Background Appropriate management of anxiety disorders in primary care requires clinical assessment and monitoring of the severity of the anxiety. This study focuses on the Beck Anxiety Inventory (BAI as a severity indicator for anxiety in primary care patients with different anxiety disorders (social phobia, panic disorder with or without agoraphobia, agoraphobia or generalized anxiety disorder, depressive disorders or no disorder (controls. Methods Participants were 1601 primary care patients participating in the Netherlands Study of Depression and Anxiety (NESDA. Regression analyses were used to compare the mean BAI scores of the different diagnostic groups and to correct for age and gender. Results Patients with any anxiety disorder had a significantly higher mean score than the controls. A significantly higher score was found for patients with panic disorder and agoraphobia compared to patients with agoraphobia only or social phobia only. BAI scores in patients with an anxiety disorder with a co-morbid anxiety disorder and in patients with an anxiety disorder with a co-morbid depressive disorder were significantly higher than BAI scores in patients with an anxiety disorder alone or patients with a depressive disorder alone. Depressed and anxious patients did not differ significantly in their mean scores. Conclusions The results suggest that the BAI may be used as a severity indicator of anxiety in primary care patients with different anxiety disorders. However, because the instrument seems to reflect the severity of depression as well, it is not a suitable instrument to discriminate between anxiety and depression in a primary care population.

  18. T-2 toxin contamination in grains and selenium concentration in drinking water and grains in Kaschin-Beck disease endemic areas of Qinghai Province.

    Science.gov (United States)

    Sun, Li-Yan; Li, Qiang; Meng, Fan-Gang; Fu, Ying; Zhao, Zhi-Jun; Wang, Li-Hua

    2012-12-01

    It has been strongly suggested that two factors are involved in the development of Kaschin-Beck Disease (KBD), namely grains contamination with T-2 toxin and selenium deficiency. So our team undertook a survey about grains and drinking water in three rural KBD endemic villages and one non-KBD village in Qinghai Province. The level of T-2 toxin contamination in 364 grain samples was assayed using an ELISA kit. The selenium concentration in these grains and 15 drinking water samples from three KBD endemic villages were determined using the 2,3-diaminonaphthalene fluorometric assay. The results revealed that the level of T-2 toxin contamination in the samples from three KBD endemic villages was relatively high with an average level of 78.91 ng/g in wheat and 47.47 ng/g in flour. The T-2 toxin level in samples from the non-KBD village (12.23 ng/g) was significantly lower than that of local grains from the three KBD endemic villages. The average selenium content in wheat and flour from KBD areas was 0.0045 and 0.0067 μg/g, respectively. The selenium concentration in local grain samples was significantly lower than that in samples from the non-KBD village (0.0604 μg/g). In addition, the selenium concentration in drinking water from three KBD endemic villages was also low (0.156 μg/L). These results support a potential role of T-2 toxin contamination and selenium deficiency in KBD. Compared with non-KBD endemic areas, health hazards in grains and in the environment of KBD endemic areas were observed.

  19. A general factor model for the Beck Depression Inventory-II: validation in a sample of patients hospitalized with acute myocardial infarction.

    Science.gov (United States)

    Thombs, Brett D; Ziegelstein, Roy C; Beck, Christine A; Pilote, Louise

    2008-08-01

    Many studies have linked symptoms of depression after an acute myocardial infarction (AMI) to negative health outcomes, including mortality. It has been suggested, however, that this link may be due to biased measurement of depressive symptoms in post-AMI patients related to confounding with somatic symptoms related to AMI. The objective of this study was to validate a factor model for the Beck Depression Inventory-II (BDI-II) that would allow for modeling of depressive symptoms after explicitly removing bias related to somatic symptom overlap. A total of 477 hospitalized post-AMI patients from 10 cardiac care units were administered the BDI-II. Confirmatory factor analysis models for ordinal data were conducted with MPLUS to test the fit of a model with a single General Depression factor (all 21 BDI-II items) and uncorrelated Somatic (5 items) and Cognitive (8 items) factors (G-S-C model) compared to standard correlated two-factor models. The G-S-C model fit as well or better than previously published correlated two-factor models. Seventy-three percent of variance in BDI-II scores is accounted for by the General Depression factor, whereas 11% and 13% respectively are accounted for by uncorrelated Somatic and Cognitive factors. The G-S-C model is a novel approach to understanding the measurement structure of the BDI-II, presents advantageous statistical and interpretive properties compared to standard correlated factor models, and provides a viable mechanism to test links between symptoms of depression, as measured by the General Depression factor, and health outcomes among patients with AMI after explicitly removing variance from somatic symptoms unrelated to the General Depression factor.

  20. Development and preliminary validation of a short form of the Beck Depression Inventory for Youth (BDI-Y) in a sample of adolescent cancer survivors.

    Science.gov (United States)

    Blackmon, Jaime E; Liptak, Cori; Recklitis, Christopher J

    2015-03-01

    The aim of this study was to analyze adolescent cancer survivors' responses to the Beck Depression Inventory for Youth (BDI-Y) to determine if a short form of the measure could be developed that would accurately identify survivors with clinically significant levels of depressive symptoms. Two hundred two adolescent survivors (mean age = 15.39 years, SD = 1.93) completed the BDI-Y at a single time point and were divided into two groups: a derivation sample (n = 105) and a replication sample (n = 97). Based on correlations with the total BDI-Y score in the derivation sample, items were selected for inclusion in three potential short forms, with 6, 8, and 11 items, respectively. These short forms were then evaluated against the full BDI-Y scale first in the derivation sample and subsequently in the replication sample (n = 97). Each of the three short forms had high correlations with the total BDI-Y scale (r > 0.95), good internal consistency (α > 0.80), and good overall discrimination compared to a standard BDI-Y cutoff score (AUC > 0.90). The eight-item short form demonstrated notable consistency across the derivation and replication samples, with high sensitivity and specificity using a cutoff score of ≥5, making it a promising tool for clinical screening. Abbreviated versions of the BDI-Y can accurately detect depression in adolescent cancer survivors. An eight-item short form demonstrates strong psychometric properties and potential for use as a screening measure in this population, while the 6- and 11-item short forms may be suited to other applications.

  1. Symptom reporting on the Beck Depression Inventory among post-myocardial infarction patients: in-hospital versus follow-up assessments.

    Science.gov (United States)

    Delisle, Vanessa C; Arthurs, Erin; Abbey, Susan E; Grace, Sherry L; Stewart, Donna E; Steele, Russell J; Ziegelstein, Roy C; Thombs, Brett D

    2012-11-01

    Depressive symptoms following myocardial infarction (MI) are often assessed using self-report questionnaires, such as the Beck Depression Inventory (BDI). No studies have examined whether depressive symptom scores assessed by self-report questionnaires during hospitalization post-MI are influenced by factors related to the acute event or hospitalization compared to subsequent outpatient assessments of the same patients. The objective of this study was to compare BDI total scores, somatic scores, and cognitive/affective scores among post-MI patients in-hospital versus at post-discharge follow-up. Secondary analysis of data from two existing cohorts of post-MI patients (Groningen, The Netherlands and Toronto, Canada). In-hospital BDI scores and follow-up scores were compared using paired samples t-tests. There were 1556 patients from the Groningen sample with BDI data in-hospital and at 3-months post-MI and 229 patients from Toronto with data in-hospital and at 6-months post-MI. BDI total, somatic, and cognitive/affective scores did not differ significantly between in-hospital and follow-up assessments in either sample. Similarly, there were no substantive differences in symptom composition in either sample. Somatic symptoms accounted for 66.3% of total BDI scores in-hospital versus 64.9% at 3-months post-MI for Groningen patients and for 62.1% of total scores in-hospital versus 64.3% at 6-months post-MI for Toronto patients. Overall BDI total scores, somatic scores, and cognitive/affective scores did not differ between in-hospital and subsequent outpatient assessments. The timing of when depressive symptoms are assessed post-MI does not appear to influence the overall level of BDI scores or the composition of symptoms that are reported. Copyright © 2012 Elsevier Inc. All rights reserved.

  2. Adaptation and Latent Structure of the Swahili Version of Beck Depression Inventory-II in a Low Literacy Population in the Context of HIV.

    Science.gov (United States)

    Abubakar, Amina; Kalu, Raphael Birya; Katana, Khamis; Kabunda, Beatrice; Hassan, Amin S; Newton, Charles R; Van de Vijver, Fons

    2016-01-01

    We set out to adapt the Beck Depression Inventory (BDI)-II in Kenya and examine its factorial structure. In the first phase we carried out in-depth interviews involving 29 adult members of the community to elicit their understanding of depression and identify aspects of the BDI-II that required adaptation. In the second phase, a modified version of BDI-II was administered to 221 adults randomly selected from the community to allow for the evaluation of its psychometric properties. In the third phase of the study we evaluated the discriminative validity of BDI-11 by comparing a randomly chosen community sample (n = 29) with caregivers of adolescents affected by HIV (n = 77). A considerable overlap between the BDI symptoms and those generated in the interviews was observed. Relevant idioms and symptoms such as 'thinking too much' and 'Kuchoka moyo (having a tired heart)' were identified. The administration of the BDI had to be modified to make it suitable for the low literacy levels of our participants. Fit indices for several models (one factorial, two-factor model and a three factor model) were all within acceptable range. Evidence indicated that while multidimensional models could be fitted, the strong correlations between the factors implied that a single factor model may be the best suited solution (alpha [0.89], and a significant correlation with locally identified items [r = 0.51]) confirmed the good psychometric properties of the adapted BDI-II. No evidence was found to support the hypothesis that somatization was more prevalent. Lastly, caregivers of HIV affected adolescents had significantly higher scores compared to adults randomly selected from the community F(1, 121) = 23.31, p depressive symptoms which can be used alongside other measures for proper diagnosis in a low literacy population.

  3. The electronic structure and optical properties of XSi(X = Fe,Ru,Os): A first principles investigation within the modified Becke-Johnson exchange potential plus LDA

    Energy Technology Data Exchange (ETDEWEB)

    Li Jia, E-mail: jiali@hebut.edu.cn; Zhang Zhidong; Ji Qing; Zhang Hui; Luo Hongzhi

    2012-10-05

    Highlights: Black-Right-Pointing-Pointer Reproduce of band gap for XSi(X = Fe,Ru,Os) with gap of {approx}10{sup -1} eV. Black-Right-Pointing-Pointer Using the mBJ + LDA first principles in comparison with GGA and LDA. Black-Right-Pointing-Pointer Theoretical optical conductivity is in agreement with the measurement. - Abstract: The electronic structure, optical reflectivity spectra and optical conductivity of semiconducting transition-metal silicides FeSi, RuSi and OsSi have been investigated by using first principles calculation within the recent developed modified Becke-Johnson exchange potential plus local-density approximation (mBJ + LDA). The electronic structures produced by mBJ + LDA, generalized gradient approximation (GGA) and LDA are rather similar although the band gap has been enlarged more or less by the mBJ + LDA compared to the GGA and LDA for the three compounds. The mBJ + LDA, GGA and LDA all have overestimated the band gap for FeSi and OsSi compared to the experiment. For RuSi, the theoretical gap values are basically close to the experimental values and the improvement of gap by mBJ + LDA is only 0.04 eV in comparison with the GGA. The mBJ + LDA and GGA also produce similar results with respect to their optical properties including the reflectivity spectra and optical conductivity except that for the reflectivity spectra of FeSi, the GGA result is little better consistent with the experimental measurement than the mBJ + LDA result. The optical conductivity calculated by mBJ + LDA and GGA both exhibits the absorption edge, in well correspondence to the optical measurement.

  4. Genome-wide pathway-based association study implicates complement system in the development of Kashin-Beck disease in Han Chinese.

    Science.gov (United States)

    Zhang, Feng; Wen, Yan; Guo, Xiong; Zhang, Yingang; Wang, Sen; Yang, Tielin; Shen, Hui; Chen, Xiangding; Tan, Lijun; Tian, Qing; Deng, Hong-Wen

    2015-02-01

    Kashin-Beck disease (KBD) is a chronic osteochondropathy. The pathogenesis of KBD remains unknown. To identify relevant biological pathways for KBD, we conducted a genome-wide pathway-based association study (GWPAS) following by replication analysis, totally using 2743 Chinese Han adults. A modified gene set enrichment algorithm was used to detect association between KBD and 963 biological pathways. Cartilage gene expression analysis and serum complement measurement were performed to evaluate the functional relevance of identified pathway with KBD. We found that the Complement and Coagulation Cascades (CACC) pathway was significantly associated with KBD (P value=3.09×10(-5), false-discovery rate=0.042). Within the CACC pathway, the most significant association was observed at rs1656966 (P value=1.97×10(-4)) of KNG1 gene. Further replication study observed that rs1656966 (P value=0.037) was significantly associated with KBD in an independent validation sample of 1026 subjects. Gene expression analysis observed that CFD (ratio=3.39±2.68), A2M (ratio=3.67±5.63), C5 (ratio=2.65±2.52) and CD46 (ratio=2.29±137) genes of the CACC pathway were up-regulated in KBD articular cartilage compared to healthy articular cartilage. The serum level of complement C5 in KBD patients were significantly higher than that in healthy controls (P value=0.038). Our study is the first to suggest that complement system-related CACC pathway contributed to the development of KBD. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Investigation of structural and multiferroic properties of three phases of BiFeO3 using modified Becke Johnson potential technique

    Science.gov (United States)

    Sagar, Elle; Mahesh, R.; Pavan Kumar, N.; Venugopal Reddy, P.

    2017-11-01

    Electronic band structure, ferroelectric and ferromagnetic properties of Cubic, Tetragonal and Rhombohedral (hexagonal axis) phases of multiferroic BiFeO3 compound has been investigated using first-principles calculations under the generalized gradient (GGA) and TB-mBJ semi local (Tran-Blaha modified Becke-Johnson) potential approximations using WIEN2k code. For this purpose, the total energies were calculated as a function of reduced volumes and the data were fitted to Brich Murnaghan equation. The estimated ground state parameters are found to be comparable with those of experimental ones. The semiconducting behavior of the material was obtained using TB-mBJ method in the spin polarized mode. Analysis of the density of states indicates that the valence band consists of Fe-d and O-p states, while the conduction band is composed of Fe-d and Bi-p states. The analysis of electron localization function shows that stereochemically active lone-pair electrons are present at Bi sites of Rhombohedral and Tetragonal phases and are responsible for the displacements of Bi atoms from the centro-symmetric to the non-centrosymmetric structure leading to the exhibition of ferroelectricity. Further, it has been concluded that the ;lone pair; may have been formed due to the hybridization of 6s and 6p atomic orbitals with 6s2 electrons filling one of the resulting orbitals in Bi. The Polarization and the magnetic properties including susceptibility were obtained. The calculated magnetic moments at the iron sites are not integer values, since Fe electrons have a hybridization interaction with the neighboring O ions.

  6. Psychometric properties and measurement equivalence of the English and Chinese versions of the Beck Anxiety Inventory in patients with breast cancer.

    Science.gov (United States)

    Ke, Yu; Ng, Terence; Yeo, Hui Ling; Shwe, Maung; Gan, Yan Xiang; Chan, Alexandre

    2017-02-01

    There is a lack of psychometric data for both the English and Chinese versions of Beck Anxiety Inventory (BAI) to support its usage among breast cancer patients. This study examined the psychometric properties and measurement equivalence of the English and Chinese versions of BAI among breast cancer patients in Singapore. Patients were recruited from two major cancer centers in Singapore. The criterion and construct validity of BAI was assessed by its correlation strength with (1) the emotional functioning subdomain of EORTC QLQ-C30 and (2) constructs related to anxiety, namely fatigue, dyspnea, and quality of life. The known-group validity was assessed according to the patients' breast cancer stage, religious beliefs, and emotional functioning levels. The internal consistency of the BAI domains was evaluated using Cronbach's alpha coefficient. Regression analysis was performed to compare the BAI total and domain scores between the two language versions. Data from 244 patients (144 English-speaking and 100 Chinese-speaking) were analyzed. For both language versions, the BAI total scores correlated moderately with the EORTC QLQ-C30 emotional functioning subdomain (r = -0.655 and -0.601). Correlations with fatigue, quality of life, and dyspnea were moderate (|r| = 0.456-0.606). Patients with poorer emotional functioning reported higher anxiety levels, establishing known-group validity. All BAI domains demonstrated satisfactory internal consistencies (α = 0.74-0.87), except for the panic domain (α = 0.57-0.61). Possible measurement equivalence between the language versions was established. Both English and Chinese versions of BAI are valid, reliable, and possibly equivalent for future use.

  7. [Rolf Hammel-Kiesow. Der Lübecker Katasterplan des 19. Jahrhunderts als historische Quelle. Überlegungen zur Stadtentwicklung Lübecks aus archäologischer, historischer und bauhistorischen Zicht] / Dennis Hormuth

    Index Scriptorium Estoniae

    Hormuth, Dennis

    2013-01-01

    Arvustus : Rolf Hammel-Kiesow. Der LÜbecker Katasterplan des 19. Jahrhunderts als historische Quelle. Überlegungen zur Stadtentwicklung Lübecks aus archäologischer, historischer und bauhistorischen Sicht. In: Stadtgründung und Stadterweiterung. Beiträge von Archäologie und Stadtgeschichtsforschung (=Beiträge zur Geschichte der Städte Mitteleuropas XXII). Linz, 2011. S. 75-104

  8. Study of wurtzite and zincblende GaN/InN based solar cells alloys: First-principles investigation within the improved modified Becke-Johnson potential

    KAUST Repository

    Ul Haq, Bakhtiar

    2014-09-01

    Wurtzite GaInN alloys with flexible energy gaps are pronounced for their potential applications in optoelectronics and solar cell technology. Recently the unwanted built-in fields caused by spontaneous polarization and piezoelectric effects in wurtzite (WZ) GaInN, has turned the focus towards zinc-blende (ZB) GaInN alloys. To comprehend merits and demerits of GaInN alloys in WZ and ZB structures, we performed a comparative study of the structural, electronic and optical properties of Ga1-xInxN alloys with different In concentration using first-principles methodology with density function theory with generalized gradient approximations (GGA) and modified Becke-Johnson (mBJ) potential. Investigations pertaining to total energy of GaInN for the both phases, demonstrate a marginal difference, reflecting nearly equivalent stability of the ZB-GaInN to WZ-GaInN. The larger ionic radii of indium (In), result in larger values of lattice parameters of Ga1-xInxN with higher In concentration. For In deficient Ga1-xInxN, at first, the formation enthalpies increase rapidly as the In content approaches to 45% in WZ and 47% in ZB, and then decreases with the further increase in In concentration. ZB-Ga1-xInxN alloys exhibit comparatively narrower energy gaps than WZ, and get smaller with increase in In contents. The smaller values of effective masses of free carriers, in WZ phase, than ZB phase, reflect higher carrier mobility and electrical conductivity of WZ-Ga1-xInxN. Moreover wide energy gap of WZ-Ga1-xInxN results in large values of the absorption coefficients comparatively and smaller static refractive indices compared to ZB-Ga1-xInxN. Comparable electronic and optical characteristics of the ZB-Ga1-xInxN to WZ-Ga1-xInxN endorses it a material of choice for optoelectronics and solar cell applications besides the WZ-Ga1-xInxN. © 2014 Elsevier Ltd.

  9. Screening for depressive symptoms among HCV-infected injection drug users: examination of the utility of the CES-D and the Beck Depression Inventory.

    Science.gov (United States)

    Golub, Elizabeth T; Latka, Mary; Hagan, Holly; Havens, Jennifer R; Hudson, Sharon M; Kapadia, Farzana; Campbell, Jennifer V; Garfein, Richard S; Thomas, David L; Strathdee, Steffanie A

    2004-06-01

    The prevalence of depression is high among injection drug users (IDUs) and among those infected with the hepatitis C virus (HCV). Moreover, one of the drugs used in the standard treatment for HCV infection (interferon) has been known to exacerbate underlying psychiatric disorders such as depression and has been associated with the development of major depressive disorder among HCV-infected patients. For these reasons, the most recent National Institutes of Health consensus statement on the management of HCV infection recommends the identification and treatment of depression prior to the start of HCV treatment. This study aimed to examine the extent of current moderate/severe depressive symptoms in a cohort of HCV-infected IDUs as measured by two screening tools, the Center for Epidemiologic Studies Depression Scale (CES-D) and the Beck Depression Inventory (BDI). Subjects were participants in a multisite behavioral intervention trial among HCV-seropositive, human immunodeficiency virus-negative IDUs aged 18-35 years; the trial was designed to prevent secondary transmission of HCV and to enhance uptake of HCV treatment. Baseline data on demographics, risk behaviors, depression, alcohol use, and health care utilization were measured via audio computer-assisted self-interview. A factor analysis was conducted on each scale to examine the clustering of items used in each to measure depressive symptoms. Baseline depressive symptoms, as measured via the CES-D and the BDI, were also compared using Pearson's correlation coefficient. Of 193 HCV-infected individuals enrolled to date, 75.6% were male, and 65.3% were white. Median age was 25.8 years. Factor analyses revealed that these scales measured depression differently; a distinct somatic component was present in the BDI, but not the CES-D. Using cutoff scores of 23 for the CES-D and 19 for the BDI, 44.0% and 41.5% of the participants were identified as having moderate/severe depressive symptoms, respectively. Over half

  10. The relevance of food composition data for nutrition surveys in rural Tibet: pilot study in the context of Kashin-Beck Disease

    Directory of Open Access Journals (Sweden)

    Dermience, M.

    2013-01-01

    Full Text Available Kashin-Beck disease (KBD is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People's Republic of China. The etiology of the disease remains obscure although environmental factors are assumed to be involved. Diet, in particular, differentiates the rural community, affected by KBD, from the other communities (nomads and city-dwellers, who remain unaffected. In anticipation of a nutrition survey, this study aimed to measure the mineral content (Ca, P, Mg, Fe, Zn, Mn, Cu, Ni, Se, Al, Sr, Mo, Cd, As, Pb, Hg, Cr, and Co of eight Tibetan staple foods and to compare the results against two food composition tables (FCTs. Foods were sampled in twenty households selected from both an endemic and a non-endemic area of rural Tibet. Ten minerals involved in bone metabolism were measured using atomic and molecular spectrometric methods. Results revealed that a very limited number of food/constituent pairs showed a variation in mineral composition during a single year of testing for a given region. In addition, results showed significant differences in mineral content between the endemic and the non-endemic area, especially for wheat flour. Following our analysis of the mineral content of the Tibetan food samples, results were statistically compared with similar foods listed in two food composition tables: the USDA National Nutrient Database (USDA Food Search for Windows, Version 1.0, database version SR23, and the China Food Composition Table (book 1, 2nd edition. More than 50 to 60% of p-values < 0.05 were highlighted, suggesting the inappropriateness of using FCTs as a reference for nutrition surveys in rural Tibet, and emphasizing the need for analysis of traditional foods. Differences were found to be more or less marked depending on the element considered, and calcium content seemed to show the greatest difference. Although it is obviously too early for definite

  11. Prevalence of depression and validation of the Beck Depression Inventory-II and the Children's Depression Inventory-Short amongst HIV-positive adolescents in Malawi

    Directory of Open Access Journals (Sweden)

    Maria H Kim

    2014-07-01

    Full Text Available Introduction: There is a remarkable dearth of evidence on mental illness in adolescents living with HIV/AIDS, particularly in the African setting. Furthermore, there are few studies in sub-Saharan Africa validating the psychometric properties of diagnostic and screening tools for depression amongst adolescents. The primary aim of this cross-sectional study was to estimate the prevalence of depression amongst a sample of HIV-positive adolescents in Malawi. The secondary aim was to develop culturally adapted Chichewa versions of the Beck Depression Inventory-II (BDI-II and Children's Depression Inventory-II-Short (CDI-II-S and conduct a psychometric evaluation of these measures by evaluating their performance against a structured depression assessment using the Children's Rating Scale, Revised (CDRS-R. Study design: Cross-sectional study. Methods: We enrolled 562 adolescents, 12–18 years of age from two large public HIV clinics in central and southern Malawi. Participants completed two self-reports, the BDI-II and CDI-II-S, followed by administration of the CDRS-R by trained clinicians. Sensitivity, specificity and positive and negative predictive values for various BDI-II and CDI-II-S cut-off scores were calculated with receiver operating characteristics analysis. The area under the curve (AUC was also calculated. Internal consistency was measured by standardized Cronbach's alpha coefficient, and correlation between self-reports and CDRS-R by Spearman's correlation. Results: Prevalence of depression as measured by the CDRS-R was 18.9%. Suicidal ideation was expressed by 7.1% (40 using the BDI-II. The AUC for the BDI-II was 0.82 (95% CI 0.78–0.89 and for the CDI-II-S was 0.75 (95% CI 0.70–0.80. A score of ≥13 in BDI-II achieved sensitivity of >80%, and a score of ≥17 had a specificity of >80%. The Cronbach's alpha was 0.80 (BDI-II and 0.66 (CDI-II-S. The correlation between the BDI-II and CDRS-R was 0.42 (p<0.001 and between the CDI

  12. Vitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients with Major Depressive Disorder: A Randomized, Controlled Clinical Trial.

    Science.gov (United States)

    Sepehrmanesh, Zahra; Kolahdooz, Fariba; Abedi, Fatemeh; Mazroii, Navid; Assarian, Amin; Asemi, Zatollah; Esmaillzadeh, Ahmad

    2016-02-01

    Vitamin D may decrease depression symptoms through its beneficial effects on neurotransmitters, metabolic profiles, biomarkers of inflammation, and oxidative stress. This study was designed to assess whether vitamin D supplementation can reduce symptoms of depression, metabolic profiles, serum high-sensitivity C-reactive protein (hs-CRP), and biomarkers of oxidative stress in patients with major depressive disorder (MDD). This randomized, double-blind, placebo-controlled clinical trial was performed in 40 patients between 18 and 65 y of age with a diagnosis of MDD based on criteria from the Diagnostic and Statistical Manual of Mental Disorders. Patients were randomly assigned to receive either a single capsule of 50 kIU vitamin D/wk (n = 20) or placebo (n = 20) for 8 wk. Fasting blood samples were taken at baseline and postintervention to quantify relevant variables. The primary [Beck Depression Inventory (BDI), which examines depressive symptoms] and secondary (glucose homeostasis variables, lipid profiles, hs-CRP, and biomarkers of oxidative stress) outcomes were assessed. Baseline concentrations of mean serum 25-hydroxyvitamin D were significantly different between the 2 groups (9.2 ± 6.0 and 13.6 ± 7.9 μg/L in the placebo and control groups, respectively, P = 0.02). After 8 wk of intervention, changes in serum 25-hydroxyvitamin D concentrations were significantly greater in the vitamin D group (+20.4 μg/L) than in the placebo group (-0.9 μg/L, P < 0.001). A trend toward a greater decrease in the BDI was observed in the vitamin D group than in the placebo group (-8.0 and -3.3, respectively, P = 0.06). Changes in serum insulin (-3.6 compared with +2.9 μIU/mL, P = 0.02), estimated homeostasis model assessment of insulin resistance (-1.0 compared with +0.6, P = 0.01), estimated homeostasis model assessment of β cell function (-13.9 compared with +10.3, P = 0.03), plasma total antioxidant capacity (+63.1 compared with -23.4 mmol/L, P = 0.04), and glutathione

  13. Relación empírica entre la Terapia Racional Emotivo-Conductual (TREC) de Ellis y la Terapia Cognitiva (TC) de Beck en una muestra costarricense

    OpenAIRE

    Cabezas Pizarro, Hannia; Lega, Leonor I.

    2012-01-01

    En este estudio se explora una posible relación empírica entre la terapia racional emotivoconductual (TREC) de Ellis y la terapia cognitiva (TC) de Beck, dos de los modelos más conspicuos en el campo de la psicoterapia cognitiva actual. Si bien este modelo utiliza el término “cognitivo” en forma tal que se encuentra asociado con el afecto, la fisiología y la conducta (Dobson, 1986), sostiene que las perturbaciones emocionales, en esencia, son causadas por el proceso cognitivo del individuo. E...

  14. Recomendaciones para la utilización de la adaptación española del Inventario de Ansiedad de Beck (BAI) en la práctica clínica

    OpenAIRE

    Jesús Sanz

    2014-01-01

    En sus 25 años de existencia, el Inventario de Ansiedad de Beck (BAI) se ha convertido en el cuestionario autoaplicado para evaluar la gravedad de la ansiedad más utilizado en los países con mayor producción científica en psicología, aunque en España dicho instrumento sigue siendo el Cuestionario de Ansiedad Estado-Rasgo (STAI). En este trabajo se presentan las características básicas del BAI en comparación con la escala de Ansiedad Rasgo del STAI, se describe el proceso de adapta...

  15. Validation of the Brazilian Portuguese version of the Beck Depression Inventory-II in a community sample Validação da versão brasileira em português do Inventário de Depressão de Beck-II numa amostra da comunidade

    Directory of Open Access Journals (Sweden)

    Marcio Henrique Gomes-Oliveira

    2012-12-01

    Full Text Available BACKGROUND: The Beck Depression Inventory (BDI is used worldwide for detecting depressive symptoms. This questionnaire has been revised (1996 to match the DSM-IV criteria for a major depressive episode. We assessed the reliability and the validity of the Brazilian Portuguese version of the BDI-II for non-clinical adults. METHODS: The questionnaire was applied to 60 college students on two occasions. Afterwards, 182 community-dwelling adults completed the BDI-II, the Self-Report Questionnaire, and the K10 Scale. Trained psychiatrists performed face-to-face interviews with the respondents using the Structured Clinical Interview (SCID-I, the Montgomery-Åsberg Depression Scale, and the Hamilton Anxiety Scale. Descriptive analysis, signal detection analysis (Receiver Operating Characteristics, correlation analysis, and discriminant function analysis were performed to investigate the psychometric properties of the BDI-II. RESULTS: The intraclass correlation coefficient of the BDI-II was 0.89, and the Cronbach's alpha coefficient of internal consistency was 0.93. Taking the SCID as the gold standard, the cut-off point of 10/11 was the best threshold for detecting depression, yielding a sensitivity of 70% and a specificity of 87%. The concurrent validity (a correlation of 0.63-0.93 with scales applied simultaneously and the predictive ability of the severity level (over 65% correct classification were acceptable. CONCLUSION: The BDI-II is reliable and valid for measuring depressive symptomatology among Portuguese-speaking Brazilian non-clinical populations.OBJETIVOS: O Inventário de Depressão de Beck (IDB é utilizado mundialmente para detectar sintomas depressivos. Este questionário foi revisado (1996 para se adequar aos critérios do DSM-IV para episódio depressivo maior. Avaliamos a confiabilidade e validade da versão I em português-brasileiro do IDB-I em uma amostra não clínica de adultos. MÉTODOS: O questionário foi aplicado em duas

  16. 2154-IJBCS-Article-Gilbert Tite Layeye

    African Journals Online (AJOL)

    hp

    faire automatiquement par utilisation d'un algorithme mathématique (Hung et al., 2005). A la fin des filtrages, les images résultantes sont importées sous le fichier type du logiciel. PCI Géomatica. A l'aide de ce dernier, nous passons une à une les images sous l'outil regroupant les algorithmes des divers traitements.

  17. 1651-IJBCS-Article-Gilbert Todou

    African Journals Online (AJOL)

    hp

    Dacryodes buettneri et Dacryodes edulis sont des espèces à usages multiples en Afrique centrale. Elles servent principalement de bois d'œuvre et de fruitier. Des échantillons de leurs folioles ont été récoltés sur 694 arbres répartis dans 29 populations au Cameroun et au Gabon, afin d'extraire l'ADNn et amplifier cinq.

  18. Gilbert Arenas ekstravertne introvert / Tanel Kapp

    Index Scriptorium Estoniae

    Kapp, Tanel

    2006-01-01

    NBA ühest ekstsentrilisemast mängijast, kes on meedia tähelepanu keskmes olnud juba esimesest hooajast peale, ent seda eelkõige oma pöörase käitumise ja koomiliste kommentaaride tõttu. Lisa: Statistika

  19. Olfaction in Accipitrid vultures | Gilbert | Vulture News

    African Journals Online (AJOL)

    No Abstract. Vulture News Vol. 55, 2006: 6-7. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

  20. 2154-IJBCS-Article-Gilbert Tite Layeye

    African Journals Online (AJOL)

    hp

    La région Zagnanado-Zogbodomey constituée de grandes dépressions et de vallée a été retenue pour mieux comprendre l'influence des eaux de ruissellement sur la qualité des eaux souterraines des aquifères continus du Bassin sédimentaire côtier. A partir d'analyses microbiologiques portant sur des échantillons.

  1. Adaptación española del Inventario para la Depresión de Beck-II (BDI-II: 3. Propiedades psicométricas en pacientes con trastornos psicológicos

    Directory of Open Access Journals (Sweden)

    JESÚS SANZ

    2005-01-01

    Full Text Available Se presentan datos sobre la fiabilidad y validez de la adaptación española del Inventario para la Depresión de Beck-II (BDI-II; Beck, Steer y Brown, 1996, obtenidos con una muestra de 305 pacientes ambulatorios con diversos diagnósticos psicopatológicos según el DSM-IV. El coeficiente alfa de fiabilidad fue alto (alfa = 0,89. Las correlaciones con otras medidas autoaplicadas y heteroaplicadas de depresión fueron elevadas y significativamente mayores que la correlación con una medida de ansiedad, lo que avala la validez convergente y discriminante del BDI-II, respectivamente. Respecto a la validez de criterio, los resultados demostraron que los pacientes diagnosticados con un trastorno depresivo mayor tenían niveles de depresión más elevados, medidos con el BDI-II, que los pacientes de otros grupos diagnósticos, aunque no hubo diferencias con los pacientes con trastornos de personalidad. Finalmente, la validación factorial del BDI-II proporcionó una solución bifactorial (factor somático- motivacional y factor cognitivo que coincide con la hallada en estudios previos. Se concluye que el BDI es un instrumento válido de detección y cuantificación de síntomas depresivos en pacientes, si bien su utilidad como herramienta para el diagnóstico diferencial de la depresión es una cuestión pendiente de investigación.

  2. Adaptación española del Inventario para la Depresión de Beck-II (BDI-II: 2. Propiedades psicométricas en población general

    Directory of Open Access Journals (Sweden)

    JESÚS SANZ

    2003-01-01

    Full Text Available Se presentan por primera vez datos normativos y de fiabilidad y validez factorial de la adaptación española del Inventario para la Depresión de Beck-II (BDI-II; Beck, Steer y Brown, 1996 obtenidos con una muestra de 470 adultos seleccionados de la población general española. La fiabilidad de consistencia interna del BDI-II fue elevada (coeficiente alfa de 0,87. Los análisis factoriales indicaron que el BDI-II mide una dimensión general de depresión compuesta por dos factores altamente relacionados, uno cognitivo-afectivo y otro somático-motivacional. En términos de consistencia interna y validez factorial, el BDI-II parece mejor instrumento para evaluar sintomatología depresiva en población general que su predecesor, el BDI-IA. La distribución de la puntuación total del BDI-II fue similar a la encontrada en estudios previos, con una media superior en 2 puntos a la que se suele obtener con el BDI-IA, lo que justifica incrementar las puntuaciones para definir las categorías de gravedad de la depresión. Además, se hallaron diferencias significativas en tales puntuaciones en función del sexo, la edad, el nivel de educación y el estado civil: las mujeres puntuaban más alto que los varones, las personas mayores de 60 años más que las personas de menor edad, las personas con estudios básicos o sin estudios más que las personas con estudios secundarios o universitarios, y las personas divorciadas, separadas o viudas más que las personas casadas o conviviendo con una pareja. Se ofrecen puntuaciones normativas para la muestra total, y se discute su utilidad para evaluar la significación clínica de los resultados de los tratamientos contra la depresión.

  3. Investigation of the structural, electronic and optical properties of the cubic RbMF{sub 3} perovskites (M = Be, Mg, Ca, Sr and Ba) using modified Becke-Johnson exchange potential

    Energy Technology Data Exchange (ETDEWEB)

    Sandeep, E-mail: sndp.chettri@gmail.com [Department of Physics, Mizoram University, Aizawl, 796004 (India); Rai, D.P. [Department of Physics, Pachhunga University College, Mizoram University, 796001 (India); Shankar, A. [Department of Physics, University of North Bengal, Darjeeling, 734013 (India); Ghimire, M.P. [Condensed Matter Physics Research Center, Butwal-13, Rupandehi, Lumbini (Nepal); IFW-Dresden, Helmholtzstraße 20, D-01069, Dresden (Germany); Khenata, R. [Laboratoire de Physique Quantique de la Mati´ere et de Modélisation Mathématique LPQ3M, Université de Mascara, Mascara, 29000 (Algeria); Bin Omran, S. [Department of Physics and Astronomy, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451 (Saudi Arabia); Syrotyuk, S.V. [Semiconductor Electronics Department, Lviv Polytechnic National University, Lviv, 79013 (Ukraine); Thapa, R.K. [Department of Physics, Mizoram University, Aizawl, 796004 (India)

    2017-05-01

    The structural, electronic and optical properties of the cubic RbMF{sub 3} perovskites (M = Be, Mg, Ca, Sr, Ba) have been investigated using the full-potential linearized augmented plane wave (FP-LAPW) method. The exchange and correlation potential was applied using the generalized gradient approximation for calculating the structural properties In addition, the modified Becke-Johnson (TB-mBJ) potential was used for calculating the electronic and optical properties. It was found that the lattice constant increases while the bulk modulus decreases with the change of cation (M) in going from Be to Ba in the RbMF{sub 3} perovskites (M = Be, Mg, Ca, Sr, Ba). The reflectivity and absorption properties were also studied using the mBJ method to understand the inter-band transitions and their possible applications in absorption devices in the UV-region. - Highlights: • Closer estimate of the band-gaps of RbMF{sub 3} with experimental results using GGA and mBJ results predicting them to be absorption devices and substrates for thin film growth. • The RbMF{sub 3} were also found to be potential candidate for in absorption devices in UV-region which were correlated to their calculated optical properties. • The materials are transparent, so may be used as substrates for thin film growth, for the optoelectric applications.

  4. Effects of the consumption of rice from non-KBD areas and selenium supplementation on the prevention and treatment of paediatric Kaschin-Beck disease: an epidemiological intervention trial in the Qinghai Province.

    Science.gov (United States)

    Sun, L Y; Meng, F G; Li, Q; Zhao, Z J; He, C Z; Wang, S P; Sa, R L; Man, W W; Wang, L H

    2014-12-01

    Based on the aetiological hypothesis of Kaschin-Beck disease (KBD), different interventions were adopted, and the preventive and therapeutic effects of interventions was observed and evaluated in this trial. A total of 358 children from seven villages of Qinghai Province in China were examined, and 280 children aged 6-11 years old were eligible for the trial. The children were divided into three groups that received either no intervention (n = 64), 150 kg/person of rice from non-KBD areas (n = 103) or 7 kg/family of selenium-iodine salt (n = 113) for 12 months. Data were collected and used to calculate the proportion of patients with X-ray lesions, the proportion of new patients and the metaphyseal repair rate. All indicators were analysed with Pearson chi-square or Fisher's exact tests. The registration number of this trial is ChiCTR-PNRC-12002309 (http://www.chictr.org). After interventions, the proportion of patients with X-ray lesions increased dramatically in the control group and decreased significantly in two intervention groups; significant differences were seen between the control group and two intervention groups (P selenium supplementation on the prevention and treatment of paediatric KBD were notable, the consumption of rice might be the most effective and safest intervention and should be encouraged. Copyright © 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

  5. 50 AÑOS DE LOS INVENTARIOS DE DEPRESIÓN DE BECK: CONSEJOS PARA LA UTILIZACIÓN DE LA ADAPTACIÓN ESPAÑOLA DEL BDI-II EN LA PRÁCTICA CLÍNICA

    Directory of Open Access Journals (Sweden)

    Jesús Sanz

    2013-09-01

    Full Text Available En 2011 se publicó la primera adaptación española del Inventario de Depresión de Beck-II (BDI-II, justo cuando se cumplía el 50º aniversario de la publicación de su primera edición. En este tiempo, el BDI se ha convertido en el cuestionario autoaplicado más utilizado en España y en el mundo para evaluar la gravedad de la depresión. En este trabajo se presentan las características básicas del BDI-II en relación con sus versiones anteriores (BDI-I y BDI-IA y el proceso de su adaptación a la población española, se resumen las propiedades psicométricas de dicha adaptación y se discute su utilización en la práctica clínica, proponiéndose pautas y puntuaciones de corte para la evaluación de la gravedad de la depresión, la evaluación de la significación clínica de los cambios terapéuticos, el cribado de personas con depresión y la ayuda en el diagnóstico diferencial de los trastornos depresivos.

  6. Contravene, write ... About the pain of others of Susan Sontag

    Directory of Open Access Journals (Sweden)

    Lucía Belén Couso

    2014-08-01

    Full Text Available Regarding the pain of others challenges our knowledge, challenges what is held as true. We appreciate this attitude condensed in the verb “to defy”. We analyze how Sontag develops her hypothesis and, from that point onward, which is the idea of criticism that emerges from the writing of Regarding the pain of others. Our analysis focuses on three of its topics: the reviewing of the ideas about the war that Virginia Woolf establishes on Three Guineas, the discussion of her own text On photography, and the criticism about Sebastião Salgado’s photography.

  7. From Estonian Exile to Executive Office / Susan Frith

    Index Scriptorium Estoniae

    Frith, Susan

    2008-01-01

    Eesti Vabariigi Presidendi Toomas Hendrik Ilvese elukäigust, haridusteest, poliitilistest vaadetest. T. H. Ilves lõpetas Pennsylvania ülikooli psühholoogia alal magistrikraadiga 1978. a. Artiklis on kasutatud telefoniintervjuud presidendiga. T. H. Ilvese kohta avaldavad arvamust ülikoolikaaslane Brian Wandell ja Eesti Rahvuskomitee Ühendriikides endine president Juhan Simonson. Ülevaade artiklist ilmunud ka: Vaba Eesti Sõna, 24. jaan. 2008, lk. 7, 10: Vaga, Airi. Eesti president Toomas H. Ilves Pennsylvania ülikooli ajakirjas

  8. Reading Susan Isaacs: toward a radically revised theory of thinking.

    Science.gov (United States)

    Ogden, Thomas H

    2011-08-01

    The author views Isaacs's (1952) paper, The nature and function of phantasy, as making an important contribution to the development of a radically revised psychoanalytic theory of thinking. Perhaps Isaacs's most important contribution is the notion that phantasy is the process that creates meaning, and that phantasy is the form in which all meanings - including feelings, defense 'mechanisms,' impulses, bodily experiences, and so on - exist in unconscious mental life. The author discusses both explicit formulations offered by Isaacs as well as his own extensions of her ideas. The latter include (1) the idea that phantasying generates not only unconscious psychic content, but also constitutes the entirety of unconscious thinking; (2) the notion that transference is a form of phantasying that serves as a way of thinking for the first time (in relation to the analyst) emotional events that occurred in the past, but were too disturbing to be experienced at the time they occurred and (3) a principal aim and function of phantasy is that of fulfilling the human need to get to know and understand the truth of one's experience. The author concludes by discussing the relationship between Isaacs's concept of phantasy and Bion's concepts of alpha function and the human need for the truth, as well as the differences between Fairbairn's and Isaacs's conceptions of the nature of unconscious internal object relationships. Copyright © 2011 Institute of Psychoanalysis.

  9. A polarised SUSANS facility to study magnetic systems

    Indian Academy of Sciences (India)

    magnet, at a small angle to the diagonal of the rectangle. Neutrons were thus de- flected by the 'magnetic air prism' [5] of 90◦ apex angle. The magnet was fabricated by attaching eight rare earth permanent magnet slabs (2 cm wide, 5 cm long and. 1.25 cm high, maximum energy product BHmax > 30 MGOe) each, just ...

  10. A polarised SUSANS facility to study magnetic systems

    Indian Academy of Sciences (India)

    Spatial pair-distribution functions for the up- and down-spins as well as the nuclear and magnetic scattering length density distributions in the micrometer domain, have ... Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India; Berlin Neutron Scattering Center, Hahn-Meitner-Institut, Glienicker ...

  11. Entretien avec Susan Holtz | CRDI - Centre de recherches pour le ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    26 nov. 2010 ... À l'échelle planétaire, toutes les institutions continueront d'évoluer et de changer, c'est sûr. C'est ce qui se passe présentement étant donné la conjugaison d'une intégration plus poussée de l'économie planétaire à l'évolution rapide des technologies, particulièrement dans le monde des communications.

  12. In Conversation with Susan Holtz | CRDI - Centre de recherches ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    In response to Chapter 8 of Agenda 21, "Integrating environment and development in decision making," IDRC undertook to research and document the practical, policy integration problems encountered in its development work. The Cornerstone of Development: Integrating Environmental, Social, and Economic Policies, ...

  13. Rene Valner ja Mikk Suursild - lihtsa elu tegelased / Susan Lahesalu

    Index Scriptorium Estoniae

    Lahesalu, Susan

    2007-01-01

    Arhitekt Rene Valner ja Mikk Suursild - tandem nimega UNITe - ehitavad ökonoomseid ja ökoloogilisi looduslikest materjalidest maju. Nende koostöös on valminud ka Peipsi ääres Nina külas 3 põhumaja. Ott Kadariku, Margit Mutso ja Kuido Kartau kommentaarid

  14. Band-gap engineering of La1-x Nd x AlO3 (x = 0, 0.25, 0.50, 0.75, 1) perovskite using density functional theory: A modified Becke Johnson potential study

    Science.gov (United States)

    Sandeep; D, P. Rai; A, Shankar; M, P. Ghimire; Anup Pradhan, Sakhya; T, P. Sinha; R, Khenata; S, Bin Omran; R, K. Thapa

    2016-06-01

    The structural, electronic, and magnetic properties of the Nd-doped Rare earth aluminate, La1-x Nd x AlO3 (x = 0% to 100%) alloys are studied using the full potential linearized augmented plane wave (FP-LAPW) method within the density functional theory. The effects of the Nd substitution in LaAlO3 are studied using the supercell calculations. The computed electronic structure with the modified Becke-Johnson (mBJ) potential based approximation indicates that the La1-x Nd x AlO3 alloys may possess half-metallic (HM) behaviors when doped with Nd of a finite density of states at the Fermi level (E F). The direct and indirect band gaps are studied each as a function of x which is the concentration of Nd-doped LaAlO3. The calculated magnetic moments in the La1-x Nd x AlO3 alloys are found to arise mainly from the Nd-4f state. A probable half-metallic nature is suggested for each of these systems with supportive integral magnetic moments and highly spin-polarized electronic structures in these doped systems at E F. The observed decrease of the band gap with the increase in the concentration of Nd doping in LaAlO3 is a suitable technique for harnessing useful spintronic and magnetic devices. Project supported by the DST-SERB, Dy (Grant No. SERB/3586/2013-14), the UGCBSR, FRPS (Grant No. F.30-52/2014), the UGC (New Delhi, India) Inspire Fellowship DST (India), and the Deanship of Scientific Research at King Saud University (Grant No. RPG-VPP-088). M P Ghimire thanks the Alexander von Humboldt Foundation, Germany for the financial support.

  15. Effect of calcium and vitamin D on growth, rickets and Kashin-Beck disease in 0- to 5-year-old children in a rural area of central Tibet.

    Science.gov (United States)

    Rooze, Shancy; Mathieu, Françoise; Claus, William; Yangzom, Tashi; Yangzom, Dikki; Goyens, Philippe; de Maertelaer, Viviane

    2016-06-01

    To evaluate the effect of calcium (15 mmol/day) and vitamin D (625 μg/month), as single supplement or in combination, vs. no supplement on growth, clinical signs of rickets and Kashin-Beck disease (KBD) and dental health. Prospective controlled trial involving children aged 0-5 years living in four groups of villages in a KBD-endemic rural area of central Tibet who received either calcium and/or vitamin D or no supplement. The cohort was followed over 3 years. Primary outcome was the impact of the different supplementation regimes on KBD, rickets and growth; secondary outcomes were impact on urinary levels of calcium and phosphorus, biomarkers of bone and cartilage turnover, and dental health. No difference was observed between the four groups with regard to anthropometric data, rickets, KBD, urinary levels of CrossLaps(®) and CartiLaps(®) . Weight for height or age, mid-upper arm circumference and skinfold thickness decreased in the four groups. Height for age increased and the prevalence of KBD fell in the four groups. Dental health was better in the group receiving calcium and vitamin D. Urinary calcium levels increased after 3 years of follow-up in all groups; the group receiving vitamin D had a higher increase (P-value: 0.044). The same global increase was observed for urinary phosphorus levels; the group receiving calcium had a higher increase (P-value: 0.01). Calcium and vitamin D failed to improve growth and bone metabolism of children living in a KBD-endemic rural area. Calcium and vitamin D supplementation improved dental health. © 2016 John Wiley & Sons Ltd.

  16. Inventário de Depressão de Beck (BDI e Escala de Avaliação de Depressão de Hamilton (HAM-D em pacientes com epilepsia

    Directory of Open Access Journals (Sweden)

    Guilherme Nogueira M. de Oliveira

    2011-01-01

    Full Text Available OBJETIVO: Determinar os pontos de melhor sensibilidade e especificidade do Inventário de Depressão de Beck (BDI e da Escala de Avaliação de Depressão de Hamilton (HAM-D no diagnóstico de depressão associada à epilepsia. MÉTODOS: Setenta e três pacientes de um centro de referência no tratamento da epilepsia foram submetidos à avaliação neuropsiquiátrica. Foram colhidos dados clínicos e sociodemográficos, sendo utilizados os seguintes instrumentos: entrevista clínica estruturada (MINI-PLUS para diagnóstico psiquiátrico conforme o DSM-IV, HAM-D e BDI. RESULTADOS: No momento da entrevista, 27,4% dos pacientes estavam deprimidos e 37% preenchiam critérios para diagnóstico de depressão maior ao longo da vida. A análise da curva ROC indicou que o ponto de corte em 16 (> 16 para o BDI (sensibilidade de 94,4%, especificidade de 90,6% e em 16 (> 16 para a HAM-D (sensibilidade de 95%, especificidade de 75,5% representou dicotomização ótima entre deprimidos e não deprimidos. Ambos os instrumentos apresentaram um valor preditivo negativo superior a 95%. CONCLUSÃO: A frequência de depressão maior é elevada em pacientes com epilepsia. BDI e a HAM-D podem auxiliar o clínico na identificação da depressão associada à epilepsia, diminuindo seu subdiagnóstico.

  17. Βιβλιοκρισία:P. SCHREINER-E. VOGT(eds., Karl Krumbacher. Leben und Werk, München, Verlag der Bayerischen Akademie der Wissenschaften in Kommission beim Verlag C. H. Beck, München 2011

    Directory of Open Access Journals (Sweden)

    Walter PUCHNER

    2013-04-01

    Full Text Available Βιβλιοκρισία: P. Schreiner-E. Vogt (eds., Karl Krumbacher. Leben und Werk, München, Verlag der Bayerischen Akademie der Wissenschaften in Kommission beim Verlag C. H. Beck, München 2011 (Bayerische Akademie der Wissenschaften, Philosophisch-historische Klasse, Sitzungsberichte, Jahrgang 2011, Heft 4, σελ. 147, 5 εικ., ΙSBN 978 3 7696 1569 0.

  18. Gene expression analysis suggests bone development-related genes GDF5 and DIO2 are involved in the development of Kashin-Beck disease in children rather than adults.

    Directory of Open Access Journals (Sweden)

    Yan Wen

    Full Text Available To investigate the differences in gene expression between children and adults with Kashin-Beck disease (KBD.12 children with KBD and 12 healthy children were selected and divided into 4 KBD vs. control pairs matched according to age and gender, with each pair having 3 KBD children and 3 healthy children. Additionally, 15 adults with KBD and 15 healthy adults were selected and divided into 5 KBD vs. control pairs matched according to age and gender, with each pair having 3 KBD adults and 3 healthy adults. Total RNA was isolated from peripheral blood mononuclear cells (PBMCs respectively. A total of 367 target genes were selected based on previous genome-wide gene expression profile analysis. Expression levels of the 367 genes were evaluated by customized oligonucleotide microarray and the differentially expressed genes were identified. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR was conducted to validate the microarray data.A total of 95 (25.9% genes in KBD children and 158 (43.1% genes in KBD adults were found to exhibit more than two-fold change in gene expression level relative to healthy controls. By comparing differentially expressed genes identified in KBD children to those of KBD adults, 42 genes were found to be differentially expressed only in KBD children. And 105 genes were found to be differentially expressed only in KBD adults. Further, 16 differentially expressed genes common to both KBD children and adults were found to be asynchronously expressed in KBD children compared to KBD adults.Significant differences in gene expression pattern were identified between KBD children and KBD adults, indicating different molecular mechanisms underlying cartilage lesions of KBD children and KBD adults. In addition, bone development-related genes GDF5 (expression ratio = 2.14±0.02 and DIO2 (expression ratio = 0.11±0.05 may contribute to the development of KBD in children rather than in adults.

  19. Prevalence of latent tuberculosis infection among foreign students in Lübeck, Germany tested with QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus.

    Science.gov (United States)

    Gallegos Morales, Elia Noemi; Knierer, Johannes; Schablon, Anja; Nienhaus, Albert; Kersten, Jan Felix

    2017-01-01

    The tuberculosis (TB) incidence rate in foreign-born individuals has been increasing in Germany in recent years. Foreign students may be an important source of latent tuberculosis infection (LTBI) in low-incidence countries. In Germany, there are no guidelines for LTBI screening of foreign students. The aim of the study was to estimate LTBI prevalence and evaluate associated risk factors among foreign students in Germany. The second purpose of our study was to compare the results of the new generation of QuantiFERON-TB Gold Plus (QFT-Plus) to those of its predecessor QuantiFERON-TB Gold In-Tube (QFT-GIT). This cross-sectional study was conducted between February 2016 and March 2016. Foreign students and young professionals attending the university and higher education institutes in Lübeck, Germany were tested with QFT-Plus and QFT-GIT. Participants filled out a questionnaire for the purpose of LTBI risk assessment and analysis. Variables associated with a positive test result were analyzed using logistic regression. One hundred thirty four students participated in the study. The overall prevalence as regards positive results from both tests, QFT-Plus and QFT-GIT, was 9.7%, and the prevalence of positive QFT-Plus results was 8.2%. The main independent variables associated with a positive QFT-Plus result were a) being born in a high-incidence country (OR = 6.7, 95% CI: 1.3-34.3) and b) previous contact with a person with active TB (OR = 4.5, 95% CI: 1.1-18.3). Higher age (OR = 2.8, 95% CI: 0.7-11.3) and male gender (OR = 1.6, 95% CI: 0.4-6.7) showed a tendency toward positive QFT-Plus results but this was not statistically significant. Agreement between QFT-Plus and QFT-GIT results was κ = 0.85, p foreign students was about 10%. We recommend implementing a policy whereby all foreign students are screened by means of a questionnaire about LTBI risk factors, so that only students with present risk factors are tested for LTBI. The agreement between the new

  20. On the applicability of Ulrich Beck's theory to Brazilian reality: health situation and political action Sobre a aplicabilidade da teoria de Ulrich Bech à realidade brasileira: situação de saúde e ação política

    Directory of Open Access Journals (Sweden)

    Aurea Maria Zöllner Ianni

    2010-09-01

    Full Text Available The present article discusses part of the results of our research on Ulrich Beck’s work, mainly focused on the Risk Society theory. Our essay discusses the relevance of the author’s theoretical propositions and their applicability to Brazilian studies. Based on the Brazilian Public Health fi eld, it indicates the health situation and the health system in the country as constitutive of social processes that reflect the theoretical questions posed by Beck. We discuss a new social inequality, the invisibility and imperceptibility of processes, the causal complexity of phenomena, the latent side effects and the (subpolitical issue. Keywords: Social theory. Risk society. Public health. Policies. Este artigo é parte dos resultados da pesquisa sobre a obra de Ulrich Beck, mais especifi camente sobre a teoria da sociedade de risco. Trata-se de um ensaio no qual se argumenta sobre a pertinência das proposições teóricas do autor e sua aplicabilidade aos estudos brasileiros. Toma-se o campo da Saúde Pública, no Brasil, como universo de análise, e mostra como a situação de saúde e o sistema de saúde, no país, refl etem as questões teóricas propostas por Beck. Abordam-se as novas desigualdades sociais, a invisibilidade e imperceptibilidade dos processos, a complexidade causal dos fenômenos, os efeitos colaterais latentes e a questão da (subpolítica, tendo sempre por referência o campo da Saúde Pública. Palavras-chave: Teoria social. Sociedade de risco. Saúde pública. Política.

  1. Post-critical behavior of Beck`s column with a tip mass

    DEFF Research Database (Denmark)

    Andersen, S. B.; Thomsen, Jon Juel

    2002-01-01

    This study examines how a tip mass with rotary inertia affects the stability of a follower-loaded cantilevered column. Using nonlinear modeling and perturbation analysis, expressions are set up for determining the stability of the straight column and the amplitude of post-critical flutter...... oscillations. Bifurcation diagrams are given, showing how the vibration amplitude changes with follower load and other parameters. These results agree closely with numerical simulation. It is found that sufficiently large values of tip mass rotary inertia can change the primary bifurcation from supercritical...

  2. Ulrich Beck : riskiühiskond / Ulrich Beck ; tõlk. Külli-Riin Tigasson

    Index Scriptorium Estoniae

    Beck, Ulrich

    2004-01-01

    Katkend raamatust "Risikogesellschaft". Autori hinnangul on tänapäeval poliitikute roll ühiskonna arengu otsustamisel kahanenud, sest võtmelise tähtsusega otsuseid teevad teadlased ja äriühingute juhid. Poliitika ja mittepoliitika vahetavad kohad

  3. Beating the Gilbert-Varshamov Bound for Online Channels

    OpenAIRE

    Haviv, Ishay; Langberg, Michael

    2011-01-01

    In the online channel coding model, a sender wishes to communicate a message to a receiver by transmitting a codeword x =(x_1,...,x_n) in {0,1}^n bit by bit via a channel limited to at most pn corruptions. The channel is online in the sense that at the ith step the channel decides whether to flip the ith bit or not and its decision is based only on the bits transmitted so far, i.e., (x_1,...,x_i). This is in contrast to the classical adversarial channel in which the corruption is chosen by a ...

  4. Coronary artery bypass grafting in a patient with Gilbert syndrome

    Directory of Open Access Journals (Sweden)

    Kemal Korkmaz

    2012-12-01

    Full Text Available Here in we present a case of a postoperative jaundicedue to Gilbert’s syndrome in a patient who was sufferingfrom coronary artery disease and undergone coronaryartery bypass grafting operation. Signs and symptoms ofjaundice developed on the postoperative first day andresolved spontaneously after 7 days. The diagnosis andcharacteristics of Gilbert’s syndrome and other relatedabnormalities and factors relevant to anesthesia and cardiopulmonaryby-pass, which affect bilirubin metabolism,are discussed. J Clin Exp Invest 2012; 3(4: 555-557Key words: Coronary artery disease, coronary artery bypassgrafting, Gilbert’s syndrome

  5. Gilbert Lake: Mark Twain National Wildlife Refuge Complex : 1981

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Mark Twain National Wildlife Refuge summarizes Refuge activities during the 1981 calendar year. The report begins with a summary of...

  6. Francis Gilbert * & Samy Zalat Introduction In collaboration with the ...

    African Journals Online (AJOL)

    Francis

    student:staff ratio is 14:1, of course with significant but not huge variation among disciplines. The total income of HE in the UK in 2004 was £ 16.9 billion (about LE 188 billion), only 60% of which comes from the UK government. The UK in general spends about 1.9% of its Gross National Product on science research.

  7. Особенности прорастания семян nepeta cataria L. var. Citriodora Beck. В лабораторных условиях

    OpenAIRE

    ШИЛОВА ИРИНА ВАСИЛЬЕВНА; ДЕМОЧКО ЮЛИЯ АЛЕКСАНДРОВНА; ИВАНОВА ЕЛЕНА ВИКТОРОВНА; ГЛАДИЛИНА ТАТЬЯНА ЮРЬЕВНА; ПЕТРОВА НАДЕЖДА АНДРЕЕВНА

    2014-01-01

    Определены энергия прорастания и всхожесть семян N. cataria L. var. citriodora Beck. Изучено влияние срока хранения, погодных условий вегетационного сезона, пониженных температур, стимулятора роста на прорастание семян.

  8. Maakoolid ja koduõpe Norras / Christian W. Beck

    Index Scriptorium Estoniae

    Beck, Christian W.

    2007-01-01

    Tänapäevane koduõpe sai Norras alguse aastatel 1991-1994. Aastail 1997-2004 püüdis meedia tähelepanu väikeste koolide sulgemine maarajoonides. Rahvas tahtis aga, et nende kodukohas oleks kool, ning kasutas oma õigust taotleda vabakooli. Avalduse käsitlemise ajal õpetasid vanemad lapsi kodus. Kohalikud koolivõimud püüdsid vanemaid takistada. Aktsiooni tulemuseks oli uut tüüpi külakoolide rajamine. Koduõpe kui väikekoolide ellujäämisstrateegia

  9. (Eds.). Lviv in the era of Adolf and Henryk Beck

    NARCIS (Netherlands)

    Zayachkivska, O.; Walentowska, W.M.; Coenen, A.M.L.

    2016-01-01

    Each generation of students and professors of the Medical Faculty of Lviv University, now known as Danylo Halytsky Lviv National Medical University, makes a considerable contribution to the development of world science through dedicated service to the ideals of truth, education, reputable and

  10. Depression in College Students; beyond the Beck Depression Inventory.

    Science.gov (United States)

    Hammen, Constance L.

    1980-01-01

    Interviews based on the Hamilton Rating Scale for Depression and the Research Diagnostic Criteria for Affective Disorders indicated that although depression was transitory for half of the students, many had diagnosable depressive disorders. (Author)

  11. BeckWith—Wiedemann syndrome (BWS): A case report and ...

    African Journals Online (AJOL)

    BWS. American Journal of Roentgenology 1997; 168(2):. 520 — 2. 12. Garvey MT, Daly D, McNamara T and BWS Dental Man- agement. International Journal of Paediatric Dentistry 1997;. 7(2): 95 ~ 9. i. 13. Debaun MR, Siegel MJ and Choyke PL. Neilihromegaly in infancy and early childhood: a risk factor for Wilm's tumour.

  12. BeckWith—Wiedemann syndrome (BWS): A case report and ...

    African Journals Online (AJOL)

    cations for partial glossectomy include recurrent airway ob- struction, poor speech development, cosmesis and prevention of development of mandibular prognatism. Maldescended tes- tes should be fixed as soon as possible to reduce the possible complications of subfertility, trauma, torsion and malignant trans- formation'” ...

  13. Morals, Metaphysics and The Method of Cases | Beck | South ...

    African Journals Online (AJOL)

    In this paper I discuss a set of problems concerning the method of cases as it is used in applied ethics and in the metaphysical debate about personal identity. These problems stem from research in social psychology concerning our access to the data with which the method operates. I argue that the issues facing ethics are ...

  14. Longitudinal measurement invariance of the Beck Scale for Suicide Ideation.

    NARCIS (Netherlands)

    Beurs, D.P. de; Fokkema, M.; Groot, M.H. de; Keijser, J. de; Kerkhof, A.J.F.M.

    2015-01-01

    In mental health care, both clinical and scientific decisions are based on within-subject comparisons of test scores on the same self-report questionnaire at different points in time. To establish the validity of test score comparisons over time, longitudinal measurement invariance should be

  15. Going narrative: Schechtman and the Russians | Beck | South ...

    African Journals Online (AJOL)

    No Abstract. South African Journal of Philosophy Vol. 27 (2) 2008: pp. 69-79. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/sajpem.v27i2.31502 · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

  16. Kaksikud lahendavad geneetilised mõistatused / Rasmus Thirup Beck

    Index Scriptorium Estoniae

    Beck, Rasmus Thirup

    2015-01-01

    Maailma ainsate astronautidest ühemunarakukaksikute Mark ja Scott Kellyga tehtud katsete ajal tehakse kindlaks, kuidas reageerib inimese organism pikaajalisele viibimisele kosmosekeskkonnas. Ka teistest kaksikute uuringutest

  17. Avalik kiri Euroopa tulevikust / Anthony Giddens, Ulrich Beck

    Index Scriptorium Estoniae

    Giddens, Anthony

    2005-01-01

    Autorid kutsuvad üles mõtlema Euroopa Liidust mitte kui "lõpetamata (rahvus)riigist" või "poolikust föderaalriigist", vaid pigem kui uuelaadsest kosmopoliitsest projektist. Kui Euroopa soovib, et teda maailmas kuulda võetaks, siis ei saa me deklareerida laienemise lõppemist ega loobuda EL-i juhtimismudeli muutmisest

  18. In Appreciation of Claude Warren and Susan Rose's "William Pengelly's Techniques of Archaeological Excavation"

    Directory of Open Access Journals (Sweden)

    David L. Browman

    1997-11-01

    Full Text Available The short (40 pages pamphlet by Warren and Rose (1994 provides the answer to a complex question regarding credit for an important archaeological methodology, stratigraphic excavation. Let me set the stage for this appreciation. Continuing research on the beginnings of stratigraphic excavations in North America (Browman and Givens 1996, I sought the origins of the idea of actually excavating by strata, rather than post-facto interpretation, seen in North American as early as 1895 in the work of Henry Chapman Mercer, but not really introduced into the repertoire of American techniques until the work of Gamio, Kidder and Nelson between 1911 and 1914. The roots of the latter three seemed to lie with individuals such as Reisner, Boas, Uhle, who in turn seemed to rely on Hugo Obennaier, Gabriel de Mortillet, Marcellin Boule, and perhaps Pitt-Rivers, while Mercer's work could be traced to Boule and Albert Gaudry. Doggedly following back the roots, I found that Chapman (1989 could make a reasonable case that Pitt-Rivers had actually learned of the idea of strati­graphic excavation from Evans, Prestwich, and Lubbock, from the British scientists working with the Upper and Middle Paleolithic excavations during 1858-1868.

  19. Nõukogude "kaasaegne stiil" : sotsialistlik modernism = The Soviet "contemporary style" : a socialist modernism / Susan E. Reid

    Index Scriptorium Estoniae

    Reid, Susan E., 1959-

    2009-01-01

    Modernismile lähenemisest nõukogude kunstis. Nõukogude kunstikriitikast ja -praktikast. Kaasaegne stiil sünteesis arhitektuuriga. Nõukogude Palee teostamata projektist Moskvas. 1962. aastal valminud Moskva Pioneeride Paleest kui stalinistliku praktika hülgamise näitest

  20. Comment on "Revisiting the 1872 owens valley, California, earthquake" by Susan E. Hough and Kate Hutton

    Science.gov (United States)

    Bakun, W.H.

    2009-01-01

    Bakun (2009) argues that the conclusions of Hough and Hutton (2008) are wrong because the study failed to take into account the Sierra Nevada attenuation model of Bakun (2006). In particular, Bakun (2009) argues that propagation effects can explain the relatively high intensities generated by the 1872 Owens Valley earthquake. Using an intensity attenuation model that attempts to account for attenuation through the Sierra Nevada, Bakun (2006) infers the magnitude estimate (Mw 7.4–7.5) that is currently accepted by National Earthquake Information Center (NEIC).

  1. David Brailer on a private-public health information technology infrastructure. Interview by Susan V. White.

    Science.gov (United States)

    Brailer, David

    2004-01-01

    David Brailer, MD PhD, was appointed the first National Health Information Technology Coordinator by the U.S. Department of Health and Human Services Secretary Tommy Thompson on May 6, 2004. As National Coordinator he is to execute President Bush's Executive Order of April 27, 2004, calling for widespread deployment of health information technology (HIT) within 10 years. Dr. Brailer is an authority on clinical data sharing, local health information exchanges, and the use of peer-to-peer technologies in healthcare. He is a leader in the strategy and financing of quality and efficiency in healthcare, with a particular emphasis on HIT and health systems management. Previously, Dr. Brailer was a Senior Fellow at the Health Technology Center in San Francisco, advising a variety of regional and national data-sharing projects and several major corporations about the role of IT in improving the quality of healthcare. Dr. Brailer recently completed 10 years as Chairman and CEO of CareScience, Inc., a provider of care management services and Internet-based solutions that help reduce medical errors and improve physician and hospital-based performance. Dr. Brailer holds doctoral degrees in both medicine and economics. While in medical school, he was a Charles A. Dana Scholar at the University of Pennsylvania School of Medicine and the first recipient of the National Library of Medicine Martin Epstein Award for his work in expert systems. Dr. Brailer was among the first medical students to serve on the Board of Trustees of the American Medical Association.

  2. 77 FR 73663 - Susan F. Knott; Denial of Hearing; Final Debarment Order

    Science.gov (United States)

    2012-12-11

    ... seeking treatment with BOTOX/BOTOX Cosmetic (BOTOX) with a product, TRI-toxin, distributed by Toxic Research International, Inc. (TRI). BOTOX is a biological product derived from botulinum toxin type A that... approved for use, to be offered for sale as an approved drug product, BOTOX. This conduct clearly relates...

  3. Cracking the finger code: an interview with CCR’s Susan Mackem | Center for Cancer Research

    Science.gov (United States)

    The creation of the digits in our hand—the thumb, index-middle-ring fingers and pinky—begins early in development, but little is known about the exact programming that occurs to produce the different digit types. Investigators in the Cancer and Developmental Biology Laboratory, (CDBL), provide the first genetic evidence of how the tuning of signals sets digit identity by studying the effects of dysregulation (abnormal regulation) in several mutations. Read more…

  4. Ten questions to Gilbert Ruelle: the wind energy, an energy for the 21. century; Dix questions a Gilbert Ruelle L'eolien, une energie du 21. siecle

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    The author gives explanations and answers and comments data on issues related to wind energy. He discusses why this energy which is one of the oldest, emerges in the 21. century again, what is its share in electricity production and what it may become, how to compare KWh costs (wind and other sources), what are the other consequences of wind intermittence, whether wind energy is actually a promising way to reduce greenhouse gas emissions, where this energy is growing the fastest, what are the best wind sites, what is the potential of offshore wind facilities, what are the other limits of the wind energy development, whether wind energy has a different behaviour than other generators with respect to network disturbances, what are the selling condition, what is the role of the European Union in the development of solar energy in France.

  5. Using the Gilbert-Johnson-Keerthi Algorithm for Collision Detection in System Effectiveness Modeling

    Science.gov (United States)

    2015-09-01

    ACDn ·AO > 0: ADn = ACDn×AD ACn = AC×ACDn if ADn ·AO > 0: self.next_simplex = Simplex([D, A]) self.next_direction = AD×AO×AD elif ACn ·AO > 0...ABn = ADBn×AB ADn = AD×ADBn if ABn ·AO > 0: self.next_simplex = Simplex([B, A]) self.next_direction = AB×AO×AB elif ADn ·AO > 0: self.next_simplex

  6. Page 1 110 Tetsuji Kametani et al Gilbert B. Autonaccio L.D and ...

    Indian Academy of Sciences (India)

    Johnson W S 1976 Angew. Chem., Int. Ed. Engl. 159. Johnson W S. Werthermann L, Bartlett W.R., Brocksom J J, Lee T. Faulkner D J and Peterson M R 1970. J. Am. Chem. Soc. 92 741 -. Jung M E 1976 Tetrahedron 32 3. Jung M E and Halweg K M 1981 Tetrahedron Lett. 22 3929. Jung M E and Shaw T J 1980 J. Am. Chem ...

  7. Data from Oceanographer, Lydonia, and Gilbert Canyons acquired in 1965 (SCHWARTZ65 shapefile)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Submarine canyons occur at the edge of the continental shelf and cut across the slope and rise along the U.S. east coast. Three of these canyons (Oceanographer,...

  8. 78 FR 52172 - Don W. Gilbert Hydro Power, LLC; Notice of Availability of Environmental Assessment

    Science.gov (United States)

    2013-08-22

    ... landscape. Cultural Resources No cultural resources eligible for or included in the National Register of... objects significant in American history, architecture, engineering, and culture that are eligible for...

  9. Perpendicularly magnetized Co20Fe60B20 layer sandwiched between Au with low Gilbert damping

    Science.gov (United States)

    Kuświk, Piotr; Głowiński, Hubert; Coy, Emerson; Dubowik, Janusz; Stobiecki, Feliks

    2017-11-01

    Nowadays, the CoFeB thin layered film is intensively studied because of its potential applications in spintronic devices, especially devices based on spin-transfer torque phenomena. Hitherto, it has been shown that CoFeB may possess perpendicular magnetic anisotropy (PMA) when it is sandwiched between different layers (e.g. MgO, Pt, Pd, Ta, W). However, there is no experimental evidence that CoFeB, sandwiched between Au layers, has strong PMA. Moreover, in comparison with other noble metals, Au-based film systems exhibit the smallest spin pumping effect, which provides the main contribution to the damping in thin films in contact with heavy metals. Therefore, Au/CoFeB/Au may be a good candidate for future applications, where perpendicular magnetic anisotropy and low damping are required. Here, we show that PMA and low damping can be achieved in a Au/CoFeB/Au system without annealing.

  10. Magnetic Circuit Model combined with Play Model Obtained from Landau-Lifshitz-Gilbert Equation

    Science.gov (United States)

    Tanaka, H.; Nakamura, K.; Ichinokura, O.

    2017-10-01

    This paper presents a novel magnetic circuit model considering magnetic hysteresis behavior, in which dc hysteresis is expressed by a play model while classical and anomalous eddy current losses are calculated by magnetic circuit elements. We describe an efficient method for obtaining the play model from the minimum measured B-H loops. It is proved that the proposed magnetic circuit model can calculate hysteresis loops under Pulse Width Modulation (PWM) excitation with high accuracy in a short time.

  11. Gilbert syndrome acts as a risk factor of developing gallstone among β hemoglobinopathy Tunisian patients.

    Science.gov (United States)

    Chaouch, Leila; Kalai, Miniar; Chaouachi, Dorra; Mallouli, Fethi; Hafsia, Raouf; Ben Ammar, Slim; Abbes, Salem

    2015-04-01

    As a result of chronic hemolysis, hyperbilirubinemia is often observed, leading to the formation of pigment cholelithiasis which could be busted by the presence of uridine diphosphoglucuronosyltransferase 1A1 defects. Herein, we investigated the effect of glibert mutation on the occurrence of pigment cholelithiasis in Tunisian patients with beta (β) hemoglobinopathy including sickle cell anemia and β thalassemia (minor). Our study included 151 subjects divided in 75 SCA patients and 76 β thalassemia patients. Both groups of patients were divided into two sub-groups according to the presence or absence of cholelithiasis. The relationship between A(TA)nTAA variation of UGT1A1 gene, the serum bilirubin level and the occurrence of cholilithiasis was investigated. Our results show a significant association between genotypes carrying variant (TA)7 and hyperbilirubinemia (p<0.05). Furthermore, we demonstrated a significant association between (TA)6/(TA)7 and (TA)7/(TA)7 genotypes with cholelithiasis among sickle cell anemia and thalassemia patients (p<0.05). Altogether, our data provide evidence that genotypes (TA)6/(TA)7 and (TA)7/(TA)7 and (TA)7 variant present a risk factor of developing gallstone among β hemoglobinopathy Tunisian patients.

  12. Perioperative management of a patient with Gilberts syndrome and rheumatic heart disease

    Directory of Open Access Journals (Sweden)

    R V Ranjan

    2012-01-01

    Full Text Available Anaesthetic management of patients with hepatic dysfunction can be quite challenging, as many anaesthetic agents are metabolized by liver. Heart disease on anti coagulation can pose additional challenge. Here we report a case of Gilbert′s syndrome with rheumatic heart disease on anti coagulation posted for elective hernia repair.

  13. Effects of Gilbert's Syndrome on Lipid Profile, Levels of Serum Uric Acid, Glucose and Insulin Resistance

    Directory of Open Access Journals (Sweden)

    Medine Cumhur Cure

    2014-06-01

    Results: Even insignificantly, GS patients had lower levels of total cholesterol whereas high-density lipoprotein was found to be higher. Conclusion: Our results shown that in GS patients, increased bilirubin levels are associated with decrease in UA, insulin, LDL, TG, and increased HDL. In GS patients, low level of UA, insulin and lipid profile may be contributed to cardioprotective effect. [Cukurova Med J 2014; 39(3.000: 443-450

  14. 75 FR 65663 - Gilbert Eugene Johnson, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-10-26

    ... establishing a valid doctor-patient relationship and a legitimate medical need for the prescription) and... * * * professional practice' and to issue a prescription for a `legitimate medical purpose,' '' as required by 21 CFR... individuals had a legitimate medical need for the prescriptions. Accordingly, I hold that in prescribing to...

  15. Insect-plant coevolution in the mountains of Sinai | Gilbert | Egyptian ...

    African Journals Online (AJOL)

    Egyptian Journal of Biology. Journal Home · ABOUT · Advanced Search · Current Issue · Archives · Journal Home > Vol 1 (1999) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Download this PDF file. The PDF file you selected should load here if your Web ...

  16. Persistent Neonatal Hyperbilirubinemia Resulting From Gilbert's Syndrome In Association With Rhd Hemolytic Disease

    OpenAIRE

    Facchini F.P.; De Assis A.M.

    2005-01-01

    OBJETIVO: Relatar associação infreqüente de patologia que cause aumento considerável de produção de bilirrubina e outra diminuição importante na sua excreção. DESCRIÇÃO: Mãe tercigesta, Rh negativo. Na primeira gestação, gerou recém-nascido normal, de termo, não tendo recebido imunoglobulina humana anti-RhD. A segunda gestação complicou-se por isoimunização Rh, dando à luz neonato de termo, o qual necessitou três exsanguinotransfusões e faleceu com 8 dias de vida. Na gestação atual, conseguiu...

  17. GILBERT SIMONDON. UNA METAFÍSICA DE LA PARTICIPACIÓN

    Directory of Open Access Journals (Sweden)

    Pierre Montebello

    2013-06-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 La filosofía de Simondon esboza, sobre la base de las ciencias de su época, una nueva metafísica de la naturaleza que engloba los niveles materiales, orgánicos y antropomórficos. El concepto de naturaleza es objeto de una profunda renovación en ella. La naturaleza ya no aparece como un conjunto de cosas hechas, definidas eternamente por su esencia. Ella es más bien la invención de procesos de individuación encajados los unos en los otros, y los cuales forman tantas dimensiones diferentes. Contrariamente al reduccionismo fisicalista que traza un mismo plano físico y determinista para todas las cosas, la naturaleza aparece en Simondon como multidimensional e inventiva. El conocimiento y la ética también son modificados por una concepción tal de la naturaleza: nosotros no conocemos y no actuamos más que participando en la naturaleza. Esta metafísica de la naturaleza es también una teoría renovada de la Participación. No estamos jamás en superposición, separados de las cosas, sino que participamos con nuestro conocimiento y nuestra acción en el movimiento íntimo de la naturaleza, en la resonancia que se establece entre sus diferentes dimensiones.

  18. Understanding Unlikeness, in John Chamberlain: Choices, Susan Davidson, ed. (New York: Solomon R. Guggenheim Museum, 2012), pp. 45–55

    OpenAIRE

    Adrian Kohn

    2017-01-01

    ere is just some of what we are given to understand John Chamberlain’s art as being like: car wrecks and dancers, artichokes and mummies and giant phalluses, drapery, a football player, ornaments for an immense Christmas tree and monstrous jungle-gyms, a sucked egg, and Titans beside themselves with rage. Next, a long list of the art-historical movements that his pieces have brought to mind: the baroque and rococo, neoclassicism, Cubism, Dada and Surrealism, both Abstract Expressionism and Po...

  19. Uncovering Our History, Teaching Primary Sources (Tarihimizi Keşfetme, Birincil Kaynaklarla Öğretim - Susan H. Veccia

    Directory of Open Access Journals (Sweden)

    Duygu Alphan Şentuna

    2014-05-01

    Full Text Available Okul yıllarından bahseden insanların büyük bir çoğunluğu için tarih dersi, not almak için isimlerin ve tarihlerin ezberlendiği, sınavdan sonra ise unutulduğu bir ders olarak hatıralarda yer alır. Günümüzde tarih öğretiminde önemli gelişmeler olmasına rağmen hala derslerde öğretmenlerin isim, tarih ve ders kitabı merkezli bir öğretim izledikleri görülmektedir. Öğrencilerin eleştirel ve tarihsel düşünme becerisi elde etmeleri için ilk önce bilgiye sahip olmaları gerektiği inancı, öğretmenlerin derslerde yenilikçi yöntemlere yeterli zaman ayırmalarını engellemektedir. Bu durum öğrencilerin tarih dersinden soğumalarına ve dersi zaman kaybı olarak görmelerine neden olmaktadır.

  20. 75 FR 22012 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition to List Susan's...

    Science.gov (United States)

    2010-04-27

    ... that incidental dispersal via wind or adhesion to animals or humans could occur, but neither dispersal... species is imperiled (at a high risk of extinction) globally due to a very restricted range, very few... Spring may be impacted by poor water quality because of large amounts of filamentous algae in Trout Creek...