Sample records for susan brown mcgreevy

  1. Susan Smith

    African Journals Online (AJOL)


    Soveel lesers soveel lokmiddele soveel re- sponse kan gelys word om toegang tot die lees van poësie te registreer. 'n Resep om ge- trou of in ontrou na te volg, bestaan nie. Ge- lukkig nie. Susan Smith se (debuut)bundel lok my helaas nie deur die voorblad as vertrek- punt te neem nie. Aan visuele prikkelkrag gaan.

  2. Dedication - Susan L Greenblatt (United States)

    Guberman, Steven L.


    Photo of Susan L Greenblatt Figure 1. Susan in May, 1994 This volume is dedicated to the memory of Susan L Greenblatt, the wife of Steven L Guberman. Susan attended 6 of the 8 dissociative recombination (DR) meetings. Her advice and wise counsel played a vital role in the organization of several of these meetings. The fifth meeting in Chicago in 2001 was her idea and it would not have occurred without her encouragement. Susan was always amused by the memory of the first group dinner at the second DR meeting at St Jacut in 1992. As we went around the dinner table identifying ourselves, it soon became her turn. Susan was a sociologist and after introducing herself she said: "I am not a chemist". A spontaneous chorus of attendees proclaimed "Neither are we!". Her husband and a few other chemists abstained. In 1983, Susan and I established the Institute for Scientific Research (ISR). The name was chosen so as to span sociology and chemical physics. Four years prior, an ophthalmologist had diagnosed a rare retinal condition of unknown origin and advised her to change her profession to one that did not involve reading. (She was able to read for the rest of her life.) Twenty years later we learned that the cause of the retinal and all her other health problems was a recently discovered rare mitochondrial mutation. Her experience with ophthalmologists and her life-long keen sense of injustice, led her to write a grant proposal to the US Department of Education to survey all ophthalmologists in the US to determine whether they were aware of and whether they told their patients about resources and aids that could help them to continue reading and participating in everyday activities. As part of the grant and based upon the survey results, she proposed to set up low-vision training programs for ophthalmology residents. We knew that the competition for funding was intense and included several well-known and more established organizations. Nevertheless, the proposal was funded

  3. Susan Flannery lahkub? / Harro Puusild

    Index Scriptorium Estoniae

    Puusild, Harro


    Ameerika teleseriaali "Vaprad ja ilusad" Stephanie Forresteri osatäitja Susan Flannery (1943) on seriaalis mänginud algusest peale s.o. 21 aastat. Lisatud intervjuu näitlejatariga. Sama ka Teleleht nr. 15, lk. 8-9 : ill

  4. In Conversation with Susan Holtz | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)


    Nov 26, 2010 ... Susan Holtz is a private consultant and Adjunct Professor in the Environmental Planning Department of the Nova Scotia College for Art and Design. As a consultant, Ms. Holtz specializes in energy, environment, and sustainable development policy, and works on related issues as a mediator and facilitator.

  5. Roberts, Dennis C. & Komives, Susan R.

    African Journals Online (AJOL)

    Enhancing Student Learning and Development in Cross-Border Higher Education, edited by. Dennis C. Roberts and Susan R. Komives, is a book that resulted from a short-term study-abroad experience between the Universities of Maryland and San Diego with the Qatar Foundation's Education City in Doha in 2010.

  6. Design package lazy susan for the fuel retrieval system

    Energy Technology Data Exchange (ETDEWEB)



    This is a design package that contains the details for a Lazy Susan style small tool for the Fuel Retrieval System. The Lazy Susan tool is used to help rotate an MCO Fuel Basket when loading it. This document contains requirements, development design information, tests and test reports that pertain to the production of Lazy Susan small tool.

  7. Psychoanalytic Interpretation of Blueberries by Susan Gibb


    Zalbidea Paniagua, Maya


    [ES] La obra de ficción digital titulada Blueberries (2009) de Susan Gibb, publicada en la ELO (Organización de literatura electrónica) invita al lector/a a viajar dentro de la mente de la protagonista para descubrir sus experiencias reales e imaginarias en las que se examinan las nociones de género, sexo, cuerpo e identidad de una mujer traumatizada. En este artículo se exploran los modos verbales y visuales en esta ficción digital breve siguiendo patrones semióticos así como se interpretan ...

  8. 75 FR 38837 - Susan Harwood Training Grant Program, FY 2010 (United States)


    ...: Notification of Funding Opportunity for Susan Harwood Training Grant Program, FY 2010. Funding Opportunity No... project performance period is $250,000. DATES: Targeted Topic training grant applications must be received... Links section, and then select ``Susan Harwood Training Grant Program''. Please note that on the Harwood...

  9. Susan Lindquist: Visionary scientist and peerless mentor. (United States)

    Bevis, Brooke J


    The science universe is dimmer after one of our brightest stars, Susan Lee Lindquist, was taken by cancer on October 27, 2016. Sue was an innovative, creative, out-of-the-box scientific thinker. She had unique biological intuition-an instinct for both the way things worked and the right questions to ask to uncover new research insights. Her wide-ranging career began with the study of protein folding and molecular chaperones, and she went on to show that protein folding can have profound and unexpected biological effects on such diverse processes as cancer, evolution, and neurodegenerative disease. As Sue's laboratory manager, I would like to offer a ground-floor perspective on what made her an exceptional scientist, mentor, and leader. She created a harmonious, collegial environment where collaborative synergy fueled meaningful progress that will impact science for decades to come. © 2017 Bevis.

  10. Psychoanalytic Interpretation of Blueberries by Susan Gibb

    Directory of Open Access Journals (Sweden)

    Maya Zalbidea Paniagua


    Full Text Available Blueberries (2009 by Susan Gibb, published in the ELO (Electronic Literature Organization, invites the reader to travel inside the protagonist’s mind to discover real and imaginary experiences examining notions of gender, sex, body and identity of a traumatised woman. This article explores the verbal and visual modes in this digital short fiction following semiotic patterns as well as interpreting the psychological states that are expressed through poetical and technological components. A comparative study of the consequences of trauma in the protagonist will be developed including psychoanalytic theories by Sigmund Freud, Jacques Lacan and the feminist psychoanalysts: Melanie Klein and Bracha Ettinger. The reactions of the protagonist will be studied: loss of reality, hallucinations and Electra Complex, as well as the rise of defence mechanisms and her use of the artistic creativity as a healing therapy. The interactivity of the hypermedia, multiple paths and endings will be analyzed as a literary strategy that increases the reader’s capacity of empathizing with the speaker.

  11. Susan Sontag — A Forgotten Mother?

    Directory of Open Access Journals (Sweden)

    Kludia Ziewiec


    Full Text Available The article discusses new and republished translations of Susan Sontag’s work, recently launched by the Karakter publishing house: Regarding the Pan of Others, On Photography, and Against Interpretation and Other Essays. The article focuses on the elements of Sontag’s thought that make her a forgotten mother of feminist and gender theoreticians, as well as such influential critics as Michel Foucault and Roland Barthes. The article points out to continuations of Sontag’s thought in contemporary theoretical and social projects, and to the pertinence of her critical observations on theories based on metaphysics of presence: psychoanalysis, Marxism, or hermeneutics. The article also touches upon history of war photography and related war journalism, and upon the ambivalent quality of imaging of the misery of war. It also present historical and cultural circumstances of the development of Sontag’s thought in the intellectual milieu of New York in the 1960s. The discussion recapitulates the main statements of Sontag’s essays, relating them to a wider theoretical context, which is aimed at a reappraisal of the forgotten intelectual in the history of literature.

  12. Meet EPA Scientist Susan Yee, Ph.D. (United States)

    Susan Yee, Ph.D., is an ecologist at EPA's Gulf Ecology Division. She is working on the Puerto Rico Sustainable Communities program, developing decision support tools to evaluate how alternative decisions impact coastal ecosystem goods and services

  13. Susan swan and the female grotesque Susan swan and the female grotesque

    Directory of Open Access Journals (Sweden)

    Suzana Bornéo Funck


    Full Text Available Introduced to readers as “the tallest woman freelance writer in Canada”, Susan Swan belongs to a generation of writers whose experimental, innovative fiction has proved vital in the contemporary project of de/re/constructing narrative practice. Her 1983 novel The Biggest Modern Woman of the World constitutes an excellent example of what critic Linda Hutcheon has termed “historiographic metafiction”—”fiction that is intensely, self-reflexively art, but is also grounded in historical, social, and political realities” (Canadian 13. As a conscious engagement with social and historical contexts, such fiction aims at destabilizing and subverting accepted patterns of belief by reconceptualizing and narrating possible subjectivities. By means of intertextuality, especially parody, it engages in an ideological critique in terms of both sexual and national politics. Introduced to readers as “the tallest woman freelance writer in Canada”, Susan Swan belongs to a generation of writers whose experimental, innovative fiction has proved vital in the contemporary project of de/re/constructing narrative practice. Her 1983 novel The Biggest Modern Woman of the World constitutes an excellent example of what critic Linda Hutcheon has termed “historiographic metafiction”—”fiction that is intensely, self-reflexively art, but is also grounded in historical, social, and political realities” (Canadian 13. As a conscious engagement with social and historical contexts, such fiction aims at destabilizing and subverting accepted patterns of belief by reconceptualizing and narrating possible subjectivities. By means of intertextuality, especially parody, it engages in an ideological critique in terms of both sexual and national politics.

  14. Collaborative Internet Projects: An Interview with Susan Silverman about Her Passion and Hobby. (United States)

    Strangman, Nicole


    Outlines an interview with Susan Silverman, an instructional technology integration teacher in the Comsewogue school district in Port Jefferson Station, New York. Describes Susan's transformation from technophobe to an innovator of collaborative Internet projects. (PM)

  15. Susan Dicklitch. The Elusive Promise of NGO's | Heck | Uganda ...

    African Journals Online (AJOL)

    Susan Dicklitch. The Elusive Promise of NGO's. Simon Heck. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

  16. Unwrapping the Thick Coat of Armor: A Conversation with Susan Albrecht (United States)

    Kaff, Marilyn; Teagarden, Jim; Zabel, Robert


    Susan Albrecht's career has spanned more than 40 years. During those years she has served as an English teacher, school psychologist, behavior consultant, coordinator of services, and special education faculty member. Her contributions to the field include leadership positions with the Council for Children with Behavioral Disorders. Susan shared…

  17. Practitioner Profile: An Interview with Susan Bross, AFC®

    Directory of Open Access Journals (Sweden)

    Susan Bross


    Full Text Available

    Susan Bross is a nationally accredited financial counselor who established her private practice in 1992. She currently lives in San Rafael, California. She brings a multi-faceted background and a combination of skills to her work. As a financial counselor, she works with individuals, couples, and entrepreneurs throughout the nation to help clients develop a practical and emotionally healthy relationship with money. When asked, she will tell you that she is passionate about her work because it mirrors her own hard-won path with money. Readers of the Journal will find Ms. Bross’s approach to financial therapy inspiring. She teaches simple tools for effortless and sustainable cash flow and money management. She also guides her clients to balanced attitudes and beliefs about money and success.

  18. [The Durkheim Test. Remarks on Susan Leigh Star's Boundary Objects]. (United States)

    Gießmann, Sebastian


    The article reconstructs Susan Leigh Star's conceptual work on the notion of 'boundary objects'. It traces the emergence of the concept, beginning with her PhD thesis and its publication as Regions of the Mind in 1989. 'Boundary objects' attempt to represent the distributed, multifold nature of scientific work and its mediations between different 'social worlds'. Being addressed to several 'communities of practice', the term responded to questions from Distributed Artificial Intelligence in Computer Science, Workplace Studies and Computer Supported Cooperative Work (CSCW), and microhistorical approaches inside the growing Science and Technology Studies. Yet the interdisciplinary character and interpretive flexibility of Star’s invention has rarely been noticed as a conceptual tool for media theory. I therefore propose to reconsider Star's 'Durkheim test' for sociotechnical media practices.

  19. Brown Syndrome (United States)

    ... extraction) have also been linked to acquired Brown syndrome. Inflammation of the tendon-trochlea complex (from adult and juvenile rheumatoid arthritis, systemic lupus erythematosus and sinusitis) can be ... syndrome hereditary? Hereditary cases of Brown syndrome are rare. ...

  20. Susan J. Quaal: the global and local impact of a transformational leader. (United States)

    Finlay, L D


    To be a transformational leader in nursing, one must have forever changed the course of our practice. This article highlights the qualities of a great leader, Susan J. Quaal, PhD, APRN, CVS, CCRN. Described are examples of Susan's incredible clinical expertise and also the attributes that make her such a dynamic leader in all domains of the clinical nurse specialist role: Practitioner, educator/mentor, consultant, leader/administrator, and researcher. Interwoven in this article, you will also find the threads of humility and charity that make Susan such an extraordinary human being and a blessing to all the lives she touches.

  1. Textual Rhetorics and Textual Carnivals: Susan Miller and the "Subjects" of Rhetoric and Composition. (United States)

    Reynolds, Nedra


    Reviews two books by Susan Miller: "Rescuing the Subject: A Critical Introduction to Rhetoric and the Writer" (1989) and "Textual Carnivals: The Politics of Composition" (1991). Notes how she rereads dominant histories of rhetoric and writing instruction, argues for a theory of textuality, and illustrates how attention to…

  2. Don't Take Touch for Granted: An Interview with Susan Lederman. (United States)

    Verry, Rene


    Presents an interview with Susan Lederman that contains a fascinating and informative overview of the recent developments in neuropsychological research concerning the sense of touch. Discusses the physiological processes that support this sensory experience and reveals them to be much more flexible, intricate, and adaptive than previously…

  3. Re-Establishing Social Studies as a Core Subject: An Interview with Susan Griffin (United States)

    Griffin, Susan


    NCSS Executive Director Susan Griffin was chair of the Task Force of Professional Organizations that worked with the Social Studies Assessment, Curriculum, and Instruction Collaborative (SSACI) of the Council of Chief State School Officers to initiate and guide the development of the "College, Career and Civic Life (C3) Framework for Social…

  4. Teaching Students About Stereotypes, Prejudice, and Discrimination: An Interview with Susan Fiske (United States)

    Hackney, Amy


    Susan T. Fiske is professor of psychology, Princeton University (PhD, Harvard University; honorary doctorate, Universite Catholique de Louvain-la-Neuve, Belgium). She wrote Social Cognition (with Taylor) on how people make sense of each other. Currently, she investigates emotional prejudices (pity, contempt, envy, and pride) at cultural,…

  5. Inside the Sex Ed Studio: An Interview with Susan N. Wilson (United States)

    Taverner, William J.


    "Inside the Sex Ed Studio" profiles leaders in the field of sexuality education. Susan N. Wilson, former Executive Coordinator of the Network for Family Life Education, long-time advocate for sexuality education, and the driving force behind New Jersey's K-12 mandate for comprehensive sexuality education was the first such leader to be…

  6. Unmaking Brown (United States)

    Lockette, Tim


    America's schools are more segregated now than they were in the late 1960s. More than 50 years after "Brown v. Board of Education," educators need to radically rethink the meaning of "school choice." For decades at Wake County, buses would pick up public school students in largely minority communities along the Raleigh…

  7. Brown recluse spider (image) (United States)

    The brown recluse is a venomous spider most commonly found in midwestern and southern states of the United States. It ... inch overall and has long skinny legs. The brown recluse is brown with a characteristic dark violin-shaped ...

  8. "A hint of it, with initials": adultery, textuality and publicity in Jane Austen's Lady Susan. (United States)

    Russell, Gillian


    In spite of Jane Austen's professed “eye” for an adulteress, comparatively little attention has been paid to adultery and divorce as themes and contexts of her fiction. Her unpublished epistolary novel Lady Susan has a distinctive status in Austen's oeuvre, recognized as being exemplary of her “style” and yet atypical of her later achievement. A neglected context for the novel is the extensive reporting of adultery trials in contemporary print culture and the moral panic concerning adultery in the 1780s and 1790s, focusing initially on the adulteress as the brazen woman of fashion and later as a figure of sentimentalized abjection. A particularly notorious case, that involving Lady Henrietta Grosvenor and George III's brother, the Duke of Cumberland, is directly alluded to in Lady Susan. The textual strategies of adultery trial literature, particularly its emphasis on indirection through the use of detail or “hint”, had a long-term influence on the development of Austen's fiction and her positioning of herself as a professional writer after the 1790s.

  9. Brown Recluse Spider (United States)

    ... 6.4-19.1mm) • Color: Golden brown • A dark violin/fiddle shape (see top photo) is located ... Habitat The Brown Recluse Spider builds small retreat webs behind objects of any type. Symptoms • The severity ...

  10. In the postmodern mirror: intertextuality in Angels and Insects by Antonia Susan Byatt

    Directory of Open Access Journals (Sweden)

    Buda Agata


    Full Text Available The aim of the paper is to analyse the novel Angels and Insects by Antonia Susan Byatt in terms of intertextual references. The author’s assumptions are based on the categorisation by Ryszard Nycz, who distinguishes three major types of intertexts: text versus text, text versus literary genre and text versus mimesis. Byatt uses intertextuality mainly to comment on the role of nature in the world, as well as to enhance the importance of human relationship with nature. Moreover, the writer moves towards literary criticism, discussing poems by famous artists, such as Alfred Tennyson or John Milton. In this way, the novel by Byatt is also an example of metafiction. All the narration techniques used by the English writer make the novel a typically postmodern work of art.

  11. Intermittent large amplitude internal waves observed in Port Susan, Puget Sound (United States)

    Harris, J. C.; Decker, L.


    A previously unreported internal tidal bore, which evolves into solitary internal wave packets, was observed in Port Susan, Puget Sound, and the timing, speed, and amplitude of the waves were measured by CTD and visual observation. Acoustic Doppler current profiler (ADCP) measurements were attempted, but unsuccessful. The waves appear to be generated with the ebb flow along the tidal flats of the Stillaguamish River, and the speed and width of the resulting waves can be predicted from second-order KdV theory. Their eventual dissipation may contribute significantly to surface mixing locally, particularly in comparison with the local dissipation due to the tides. Visually the waves appear in fair weather as a strong foam front, which is less visible the farther they propagate.


    Directory of Open Access Journals (Sweden)

    Sandra Camacho


    Full Text Available Looking at susan pui san lok's projects News (2005 and RoCH (2013, this paper contemplates the notions put forward by Michel-Rolph Trouillot and Jacques Derrida on the power of archivists, not solely as guardians of documents but also as their interpreters. Taking into consideration that photographic and moving image archives present unique difficulties in their cataloguing processes, I examine silences that might be generated by a thematic classification that is not impervious to archivists' biases. Moreover, I consider if the silences created by manual processes of classification and retrieval might be surpassed through digital technologies, or if it is possible that new technologies simply create different types of silencing.

  13. "I Am Not a Fairy Tale": Contextualizing Sioux Spirituality and Story Traditions in Susan Power's "The Grass Dancer" (United States)

    Diana, Vanessa Holford


    Standing Rock Sioux writer Susan Power's best-selling novel "The Grass Dancer" (1994) includes depictions of the supernatural and spiritual that do not conform to the Judeo-Christian or, in some cases, the atheist or rationalist worldviews of many readers. Power writes of ghost characters and haunted places, communication between the living and…

  14. 78 FR 75676 - Mark W. Dobronski and Susan K. Dobronski-Acquisition of Control Exemption-Adrian & Blissfield... (United States)


    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Surface Transportation Board Mark W. Dobronski and Susan K. Dobronski--Acquisition of Control Exemption... Company, Lapeer Industrial Railroad Company and Jackson & Lansing Railroad Company Mark W. Dobronski and...

  15. [Human brown adipose tissue]. (United States)

    Virtanen, Kirsi A; Nuutila, Pirjo


    Adult humans have heat-producing and energy-consuming brown adipose tissue in the clavicular region of the neck. There are two types of brown adipose cells, the so-called classic and beige adipose cells. Brown adipose cells produce heat by means of uncoupler protein 1 (UCP1) from fatty acids and sugar. By applying positron emission tomography (PET) measuring the utilization of sugar, the metabolism of brown fat has been shown to multiply in the cold, presumably influencing energy consumption. Active brown fat is most likely present in young adults, persons of normal weight and women, least likely in obese persons.

  16. Brown recluse spider envenomation. (United States)

    Furbee, R Brent; Kao, Louise W; Ibrahim, Danyal


    Brown recluse spider bite is a common diagnosis in almost every state in America. In fact, cases have been reported in areas where the spider has never been seen. A review of medical literature reveals that most current concepts regarding brown recluse spider envenomation are based on supposition. In this article, we attempt to review critically our present understanding of brown recluse bites with a focus on the published evidence.

  17. Brown Fat Cell Isolation




    Author: C.R. Kahn ### 1.) ISOLATION AND PRIMARY CULTURE OF BROWN FAT PREADIPOCYTES ### Rationale: To prepare primary brown preadipocytes for immortalization: useful for metabolic studies from knockout mice. This consists of the following five protocols. References: Fasshauer, M., J. Klein, K M. Kriauciunas, K. Ueki, M.Benito, and C.R. Kahn. 2001. Essential role of insulin substrate 1 in differentiation of brown adipocytes. *Mol Cell Biol* 21: 319-329. Fasshauer, M....

  18. Plasmodesmata of brown algae


    Terauchi, Makoto; Nagasato, Chikako; Motomura, Taizo


    Plasmodesmata (PD) are intercellular connections in plants which play roles in various developmental processes. They are also found in brown algae, a group of eukaryotes possessing complex multicellularity, as well as green plants. Recently, we conducted an ultrastructural study of PD in several species of brown algae. PD in brown algae are commonly straight plasma membrane-lined channels with a diameter of 10?20?nm and they lack desmotubule in contrast to green plants. Moreover, branched PD ...

  19. A Journey, the Pain of Others, and Historical Experience: Susan Silas

    Directory of Open Access Journals (Sweden)

    Sendyka, Roma


    Full Text Available The author interprets Susan Silas' Helmbrechts walk (1998-2003, a unique series of forty-five photographs and supplementing visual and textual materials collected during the walk along the route of two hundred and twenty-five miles. The walk repeats the route which in 1945 had to undertake women prisoners from the concentration camp in Helmbrechts near Flossenbürg in their death march to Prachatice in Czech Republic. The pictures Silas takes, the people she meets, and finally the trees, the very materiality of the road become the factors of creating her own, individual memory of the event from the past. Silas selects an object from "the margins of the Holocaust" – a forgotten event that she re-presents by reacting to contemporary objects placed along the route of the event. Silas' work offers an opportunity to critically review the concept of memory landscapes (where is memory located in a landscape? and the phenomenon of dark tourism (is following in the footsteps of the prisoners a kind of pilgrimage, tourism, or therapy?. Silas problematises the question of memory, as well as examines different kinds of non-memory. Her camera is directed at locations that can be termed "the non-sites of memory."


    Directory of Open Access Journals (Sweden)



    Full Text Available Throughout history of thought, there have been many views about the women, their status in society, their struggle with patriarchy, and inequality  applied to them in all areas. There are different ways of oppression on women, such as confinement to home, inequality in wages between both sexes.  However, few scholars have written and declared their own views about how the patriarchal world and companies form women as they wish. Susan Bordo is one of  the most outstanding and distinguished feminist writers in the world who focuses on  how patriarchal capitalist understanding works on women’s body in terms of weight and weakness. According to Susan Bordo, male dominated capital world decides on women about what to wear and what to eat and women try to lose weight to be in the form men wish. State of  starving all the time leads to an illness called anorexia. The writer bases her views on the thoughts of literary critic and thinker, Foucault. The  objective of this article is to help the readers understand Susan Bordo’s views and analyse her impressive work; Unbearable Weight: Feminism, Western Culture and  the Body  and make her known in academic world.

  1. Bárbara Mujica, ed., Shakespeare and the Spanish «Comedia». Translation, Interpretation, Performance. Essays in Honor of Susan L. Fischer

    Directory of Open Access Journals (Sweden)

    Alejandro García-Reidy


    Full Text Available Reseña de Bárbara Mujica, ed., Shakespeare and the Spanish «Comedia». Translation, Interpretation, Performance. Essays in Honor of Susan L. Fischer, Bucknell University Press, Lewisburg, 2013, 298 pp. ISBN 9781611485172.

  2. Father Brown, Selected sories

    NARCIS (Netherlands)

    Chesterton, G.K.


    Father Brown, a small, round Catholic priest with a remarkable understanding of the criminal mind, is one of literature's most unusual and endearing detectives, able to solve the strangest crimes in a most fascinating manner. This collection draws from all five Father Brown books, and within their

  3. Brown adipocyte function

    DEFF Research Database (Denmark)

    Winther, Sally

    . The first part of this thesis explores this by identifying and investigating two novel kinase regulators of brown adipocyte function. Study 1 demonstrates that spleen tyrosine kinase is a hitherto undescribed regulator of brown adipocyte differentiation and activation. Study 2 identifies glycogen synthase...... kinase 3 as a negative regulator of the canonical p38 mitogen-activated protein kinase signaling cascade. Thus both studies add novel regulatory layers to the growing understanding of brown adipocyte signal transduction. Activated BAT also exerts great influence on whole body glucose homeostasis......, of great interest for diabetes treatment. The second part of this thesis explores this by investigating glycolytic flux in activated brown adipocytes. Study 3 identifies hypoxia-inducible factor 1α as an important regulator of glycolytic gene expression in brown adipocytes. Study 4 establishes...

  4. Podróż, cudze cierpienie i doświadczenie historyczne: Susan Silas

    Directory of Open Access Journals (Sweden)

    Sendyka, Roma


    Full Text Available Autorka interpretuje pracę Susan Silas Helmbrechts walk (1998-2003, szczególny cykl czterdziestu pięciu zdjęć i dołączonych do nich materiałów wizualnych oraz tekstowych zbudowany podczas przejścia trasy dwustu dwudziestu pięciu mil, które w 1945 roku musiały przebyć kobiety pędzone w marszu śmierci z Helmbrecht koło Flossenbürga do czeskich Prachatic. Wykonywane zdjęcia, napotykani ludzie, w końcu – drzewa, sama materialność drogi stają się czynnikami wytwarzania własnej, indywidualnej pamięci wydarzenia sprzed lat. Silas wybiera szczególny obiekt "z marginesów Zagłady" – zapomniane zdarzenie, które przedstawia obserwując współczesne obiekty położone wzdłuż trasy tego zdarzenia. Praca Silas pozwala przyjrzeć się krytycznie koncepcji memory landscapes (gdzie w krajobrazie umiejscawia się pamięć? i zjawisku dark tourism (czy podążanie śladami więźniarek to pielgrzymka, turystyka czy terapia?. Silas problematyzuje nie tylko kwestię pamięci, bada również rodzaje nie-pamiętania. Jej kamera zostaje zwrócona ku lokalizacjom, które można nazwać "nie-miejscami pamięci".

  5. Treasure Your Exceptions: An Interview with 2017 George Beadle Award Recipient Susan A. Gerbi. (United States)

    Gerbi, Susan A


    THE Genetics Society of America's (GSA) George W. Beadle Award honors individuals who have made outstanding contributions to the community of genetics researchers and who exemplify the qualities of its namesake. The 2017 recipient is Susan A. Gerbi, who has been a prominent leader and advocate for the scientific community. In the course of her research on DNA replication, Gerbi helped develop the method of Replication Initiation Point (RIP) mapping to map replication origins at the nucleotide level, improving resolution by two orders of magnitude. RIP mapping also provides the basis for the now popular use of λ-exonuclease to enrich nascent DNA to map replication origins genome-wide. Gerbi's second area of research on ribosomal RNA revealed a conserved core secondary structure, as well as conserved nucleotide elements (CNEs). Some CNEs are universally conserved, while other CNEs are conserved in all eukaryotes but not in archaea or bacteria, suggesting a eukaryotic function. Intriguingly, the majority of the eukaryotic-specific CNEs line the tunnel of the large ribosomal subunit through which the nascent polypeptide exits. Gerbi has promoted the fly Sciara coprophila as a model organism ever since she used its enormous polytene chromosomes to help develop the method of in situ hybridization during her Ph.D. research in Joe Gall's laboratory. The Gerbi laboratory maintains the Sciara International Stock Center and manages its future, actively spreading Sciara stocks to other laboratories. Gerbi has also served in many leadership roles, working on issues of science policy, women in science, scientific training, and career preparation. This is an abridged version of the interview. The full interview is available on the Genes to Genomes blog, at Copyright © 2017 by the Genetics Society of America.

  6. Plasmodesmata of brown algae. (United States)

    Terauchi, Makoto; Nagasato, Chikako; Motomura, Taizo


    Plasmodesmata (PD) are intercellular connections in plants which play roles in various developmental processes. They are also found in brown algae, a group of eukaryotes possessing complex multicellularity, as well as green plants. Recently, we conducted an ultrastructural study of PD in several species of brown algae. PD in brown algae are commonly straight plasma membrane-lined channels with a diameter of 10-20 nm and they lack desmotubule in contrast to green plants. Moreover, branched PD could not be observed in brown algae. In the brown alga, Dictyota dichotoma, PD are produced during cytokinesis through the formation of their precursor structures (pre-plasmodesmata, PPD). Clustering of PD in a structure termed "pit field" was recognized in several species having a complex multicellular thallus structure but not in those having uniseriate filamentous or multiseriate one. The pit fields might control cell-to-cell communication and contribute to the establishment of the complex multicellular thallus. In this review, we discuss fundamental morphological aspects of brown algal PD and present questions that remain open.

  7. How, Now, Brown Dwarfs? (United States)

    Brecher, Kenneth


    The vocabulary of astronomy is riddled with colorful names for stars, from red giants to blue stragglers. Objects with masses between roughly .01 and .1 solar masses are called "brown dwarfs". Do they - could they - ever actually appear brown? Color is not a one-dimensional physical parameter like wavelength. It is a complex, psychophysical phenomenon involving not only three degrees of freedom - hue (often incorrectly equated with "color"), saturation and brightness - but also observational context. The perceptual nature of color has been known since Newton wrote in his "Opticks” in 1704: "For the Rays to speak properly are not coloured. In them there is nothing else than a certain Power and disposition to stir up a Sensation of this or that Colour.” To most observers, the 2000 or so naked eye stars observable from the northern hemisphere all appear white, with the half dozen exceptions which look reddish/orange like Betelgeuse, Arcturus and Antares. But what color would Betelgeuse (effective temperature 3600 K) appear at a distance of, say, 100 times the Earth-Sun separation? Not red. In fact, it has a temperature about 40% higher than that of an ordinary incandescent light bulb. It would appear white (or yellowish)! Can a very cool radiating (emissive) object ever appear brown? What is brown anyway? It is not a primary or even secondary color. In this presentation, we will explore the nature and meaning of "brown” by the use of several physical and computer demonstrations developed as part of "Project LITE- Light Inquiry Through Experiments", an educational materials development project. These demonstrations show that an isolated thermally radiating object will never appear brown. Hence the term "Brown Dwarf” is as nonsensical as the phrase "How, Now, Brown Cow?". Project LITE is supported by the NSF through DUE Grant # 0715975.

  8. Tune Your Brown Clustering, Please

    DEFF Research Database (Denmark)

    Derczynski, Leon; Chester, Sean; Bøgh, Kenneth Sejdenfaden


    Brown clustering, an unsupervised hierarchical clustering technique based on ngram mutual information, has proven useful in many NLP applications. However, most uses of Brown clustering employ the same default configuration; the appropriateness of this configuration has gone predominantly...

  9. Natural Inhibitors of Maillard Browning (United States)


    incorporated into pre-selected candidate ration components for evaluation via storage, sensory and chemical analysis. The concentration of inhibitor was...inhibiting Maillard browning, also known as non-enzymatic browning, a complex reaction which can lead to darkening of color, off- odors , off-flavors...nutritional intake, and decrease waste due to non-consumption of sensory degraded ration components. 1.1 Maillard Browning Maillard browning, also

  10. Susan Magoffin’s Santa Fe Days in 1846: The Value of Testimony Les journées de Santa Fé en 1846 de Susan Magoffin : la valeur du témoignage

    Directory of Open Access Journals (Sweden)

    Susanne Berthier-Foglar


    Full Text Available Susan Magoffin, la jeune épouse d’un commerçant de la piste de Santa Fe, accompagna son mari en 1846 pour un voyage où la caravane suivait de près l’Armée de l’Ouest et pendant lequel elle tint un journal. Cet article traite des 37 jours que dura la pause de la caravane à Santa Fe et aborde plus spécifiquement la façon dont l’auteur appréhendait l’altérité dans un environnement inhabituel et parfois dangereux. Pour apprécier la valeur du témoignage, je combine une analyse du discours avec une évaluation statistique du contenu. La description, parfois naïve, de Santa Fe sous l’occupation américaine illustre les raisons de la guerre contre le Mexique. En tant qu’agent de la destinée manifeste, Susan Magoffin admirait le général Kearny en lui attribuant des qualités surhumaines et en participant à ses efforts de propagande. Alors qu’elle était enracinée dans sa classe et sa culture, elle voyait la population mexicaine et les Amérindiens avec un esprit ouvert bien que ses motifs pour apprendre l’espagnol, ainsi que le métier de commerçante, avaient une fonction plus prosaïque.

  11. Fucoidans from brown seaweeds

    DEFF Research Database (Denmark)

    Ale, Marcel Tutor; Meyer, Anne S.


    structural details of fucoidans. Mild extraction techniques coupled with the use of new tools such as enzymes can provide the much needed knowledge about structural characteristics of different fucoidan molecules and thus pave the way for a better understanding of the structural chemistry and bioactivities......-proliferative effects on cancer cells. Recent work has revealed distinct structural features of fucoidans obtained from different brown seaweed sources. Fucoidans are classically obtained from brown seaweeds by multi-step, hot acid extraction, but the structural and compositional traits, and possibly the bioactivity......, of the fucoidan polysaccharides are significantly influenced by the extraction parameters. This review discusses the structural features of fucoidans, the significance of different extraction technologies, and reviews enzymatic degradation of fucoidans and the use of fucoidan-modifying enzymes for elucidating...

  12. [Brown recluse bite]. (United States)

    Nehemya, Moshe


    Spider bites are not uncommon in our warm climate. The most prevalent species of venomous spiders in Israel are the brown recluse and the black widow. Although the black widow is more notorious than the recluse, for every bite by a black widow there are hundreds of recluse bites reported. Despite the numerous bites, there is little awareness amongst physicians with regard to the clinical signs of recluse bites, and very often the wrong diagnosis is made, resulting in complex and unnecessary treatments. The basis of this error stems from the numerous clinical diagnoses which closely imitate a recluse bite, the relative scarceness of documented recluse bites and the fact that in most cases the spider is not witnessed by the victim. The following article describes three cases of children admitted to our department, presenting with high fever, a necrotic lesion and an extensive maculopapular rash. The children were eventually diagnosed with brown recluse bites. Furthermore, the article summarizes the literature regarding the clinical signs of recluse bites, possible complications and treatment options. The objective of this review is to increase awareness towards recluse bites, thereby preventing misdiagnoses and unnecessary treatments.

  13. ‘Speaking Kleinian’: Susan Isaacs as Ursula Wise and the Inter-War Popularisation of Psychoanalysis (United States)

    Shapira, Michal


    How did the complex concepts of psychoanalysis become popular in early twentieth-century Britain? This article examines the contribution of educator and psychoanalyst Susan Isaacs (1885–1948) to this process, as well as her role as a female expert in the intellectual and medical history of this period. Isaacs was one of the most influential British psychologists of the inter-war era, yet historical research on her work is still limited. The article focuses on her writing as ‘Ursula Wise’, answering the questions of parents and nursery nurses in the popular journal Nursery World, from 1929 to 1936. Researched in depth for the first time, Isaacs’ important magazine columns reveal that her writing was instrumental in disseminating the work of psychoanalyst Melanie Klein in Britain. Moreover, Isaacs’ powerful rebuttals to behaviourist, disciplinarian parenting methods helped shift the focus of caregivers to the child’s perspective, encouraging them to acknowledge children as independent subjects and future democratic citizens. Like other early psychoanalysts, Isaacs was not an elitist; she was in fact committed to disseminating her ideas as broadly as possible. Isaacs taught British parents and child caregivers to ‘speak Kleinian’, translating Klein’s intellectual ideas into ordinary language and thus enabling their swift integration into popular discourse. PMID:28901872

  14. Evaluation of Four Bed Bug Traps for Surveillance of the Brown Dog Tick (Acari: Ixodidae). (United States)

    Carnohan, Lucas P; Kaufman, Phillip E; Allan, Sandra A; Gezan, Salvador A; Weeks, Emma N I


    The brown dog tick, Rhipicephalus sanguineus (Latrielle), can be a serious residential pest due to its unique ability, among ticks, to complete its lifecycle indoors. A single engorged and fertilized female tick can oviposit around 4,000 eggs, allowing indoor establishment to be rapid and easy to miss in early-stage infestations. Acaricide treatment is currently the primary method of control, but can be costly and can lead to the development of acaricide resistance in tick populations. Traps of various designs can be used to help monitor and manage populations of indoor pests, such as cockroaches and bed bugs, but there are currently no commercially available traps for use with brown dog tick infestations. This study included a comparison of four commercially available bed bug traps (NightWatch [BioSensory Inc., Putnam, CT], Bed Bug Beacon [PackTite, Fort Collins, CO], ClimbUp [Susan McKnight Inc., Memphis, TN], and Verify [FMC Corporation, Philadelphia, PA]) with regard to their efficacy in capturing brown dog ticks, and also compared tick attraction to ClimbUp traps baited with several stimuli including CO2. Significantly more ticks were captured and attracted to the NightWatch and CO2-baited ClimbUp traps than the other two trap models. The results suggest that bed bug traps may be useful in brown dog tick monitoring, and CO2 will likely be an important component of a trapping system employed in the future. Published by Oxford University Press on behalf of Entomological Society of America 2015. This work is written by US Government employees and is in the public domain in the US.

  15. Diasporic Reconciliations of Politics, Love and Trauma: Susan Abulhawa’s Quest for Identity in Mornings in Jenin

    Directory of Open Access Journals (Sweden)

    Ayman M Abu-Shomar


    Full Text Available Negotiating human conditions is an emblematic critical impetus of diaspora informed by multiple cultural possibilities practiced through the creation of multiple spaces that cross the realm of the ‘self’ to that of the ‘other’. It offers a locale to cross from the oppressed ‘self’ to an understanding of an oppressor ‘other’. Yet, diasporic negotiation is politically involved in the most responsible manner; it engages the contextual social realities in order to enable creative possibilities for overcoming the logic of the politics altogether. It invites a kind of political involvement that assures the ‘situatedness of the ethical’ in a framework of moral humanistic realisations. The realisation of diasporic negotiations is dialogically engaged in manners that will give birth to new possibilities for human togetherness. In this essay, I trace the signs of diasporic negotiations of politics, love and trauma in Susan Abulhawa’s Mornings in Jenin by focusing on the Diasporic identity of Amal (the central character. I consider the intersections between diaspora, dislocation of identity and the creation of negotiating spaces that qualify an 'epistemology of Diaspora' against essentialised and ethnocentric construction of realities. I argue that Abulhawa creates diasporic spaces and immense moral scenes to transcend a particular stance of politics via transcending love in opposition to suffering and tribulation. I contend that Abulhawa’s conceptualisation of Diasporic negotiations enables her to depict and gauge two extreme human sentiments: love and trauma, yet, without yielding or compromising the right of just resistance and dissent. Keywords: Diaspora, humanism, Trauma, identity, negotiating difference, and 'Otherness'

  16. Vozvrashtshenije "Ekzorsista" / Susan Howard

    Index Scriptorium Estoniae

    Howard, Susan


    William Friedkini 1973.a. valminud õudusfilm "Exorcist", selle järjed ja selle hiljuti restaureeritud ja taas ekraanile paisatud versioon ning nende mõju näitlejanna Linda Blair'i elukäigule, kes filmis mängis saatanast vaevatud teistmelist

  17. Dennis C. Roberts & Susan R. Komives (Eds. (2016. Enhancing Student Learning and Development in Cross-Border Higher Education. San Francisco: Jossey-Bass.

    Directory of Open Access Journals (Sweden)

    Munita Dunn-Coetzee


    Full Text Available Enhancing Student Learning and Development in Cross-Border Higher Education, edited by Dennis C. Roberts and Susan R. Komives, is a book that resulted from a short-term study-abroad experience between the Universities of Maryland and San Diego with the Qatar Foundation’s Education City in Doha in 2010. This partnership challenged the way in which higher education internalisation was viewed – in such a way that the visit was replicated in 2012 and this book was authored.

  18. How brown is brown fat that we can see? (United States)

    Kolonin, Mikhail G


    There are many unanswered questions related to the heterogeneity of adipose tissue depots and the paucity of their function, development, and organization at the cellular level. Much effort has been directed at studying white adipose tissue (WAT), the driver of obesity and the associated metabolic disease. In recent years, the importance of brown adipose tissue (BAT) has also been appreciated. While BAT depots are prominent in many small mammal species, their detection in adult humans has been technically challenging and the identity of brown human adipocytes found within depots of WAT has remained controversial. We recently reported a peptide probe that binds to BAT vasculature and, when coupled with a near-infrared fluorophore, can be used to detect BAT in whole body imaging. This probe reliably discriminates between endothelium associated with brown or brown-like (beige/brite) adipocytes and endothelium of visceral WAT. Improved probes based on this approach could aid in assessing human adipose tissue body distribution and remodeling, which is a process underlying various pathologies. This commentary aims at discussing open questions that need to be addressed before full clinical advantage can be taken from adipose tissue imaging, as well as its metabolic activation strategies.

  19. Live-trapping and handling brown bear (United States)

    US Fish and Wildlife Service, Department of the Interior — This paper reports techniques developed to live trap and handle brown bears on the Kodiak National Wildlife Refuge. The brown bears (Ursus middendorffi) on the...

  20. Brown Adipose Tissue: Function and Physiological Significance

    National Research Council Canada - National Science Library



    .... Brown Adipose Tissue: Function and Physiological Significance. Physiol Rev 84: 277–359, 2004; 10.1152/physrev.00015.2003.—The function of brown adipose tissue is to transfer energy from food into heat...

  1. Hydrothermal-mechanical dewatering of brown coal


    Guo, Jian


    There are enormous reserves of brown coal in the world. In Australia, brown coal is used to generate most of electricity in the states of Victoria and South Australia. Brown coal is characterised by very high moisture content (around 60 wt% on a wet basis). Therefore, boilers used in the power station are very large and have low thermal efficiency, leading to high cost and large emissions of green house gas. High moisture content also makes brown coal uneconomical for transport...

  2. Fulfilling the Promise of Brown. (United States)

    Winston, Judith A.


    Summarizes the U.S. Department of Education's efforts to implement the mandate of "Brown v. Board of Education of Topeka, Kansas" and the Civil Rights Act of 1964, examining traditional tools used in enforcing civil rights laws and reviewing new strategies to promote high quality education, equal educational opportunity, and diversity.…

  3. 21 CFR 184.1120 - Brown algae. (United States)


    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Brown algae. 184.1120 Section 184.1120 Food and... Substances Affirmed as GRAS § 184.1120 Brown algae. (a) Brown algae are seaweeds of the species Analipus.../code_of_federal_regulations/ibr_locations.html. (c) In accordance with § 184.1(b)(2), the ingredient is...

  4. Loss of the tumour suppressor gene AIP mediates the browning of human brown fat tumours. (United States)

    Magnusson, Linda; Hansen, Nils; Saba, Karim H; Nilsson, Jenny; Fioretos, Thoas; Rissler, Pehr; Nord, Karolin H


    Human brown fat tumours (hibernomas) show concomitant loss of the tumour suppressor genes MEN1 and AIP. We hypothesized that the brown fat phenotype is attributable to these mutations. Accordingly, in this study, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumours, loss of MEN1 was found both in white (one of 51 lipomas) and in brown fat tumours. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumours is mediated by the loss of AIP. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  5. Surprising Legacies of Brown v. Board


    Minow, Martha Louise


    Perhaps the most powerful legacy of Brown v. Board is this: opponents in varied political battles fifty years later each claim ties to the decision and its meaning. So although the analogy between Brown and same-sex marriage has divided Black clergy, each side vies to inherit the civil rights heritage. President George W. Bush invoked Brown in opposing race-conscious college admission practices. The success of Brown in reshaping the moral landscape has been so profound that I fear we do not f...

  6. Seasonality of brown recluse populations is reflected by numbers of brown recluse envenomations


    Rader, RK; Stoecker, WV; Malters, JM; Marr, MT; Dyer, JA


    A significant seasonal correlation was recently shown for brown recluse spider activity. Vetter (2011) observed brown recluse spiders were submitted by the general public predominantly during April–October. For patients with suspected brown recluse spider bites (BRSB), we have observed the same seasonality. Among 45 cases with features consistent of a BRSB, 43 (95.6%) occurred during April–October. Both the Vetter study and our study serve to demonstrate seasonal activity for brown recluse sp...

  7. Enzymatic Browning: a practical class

    Directory of Open Access Journals (Sweden)

    Maria Teresa Pedrosa Silva Clerici


    Full Text Available This paper presents a practical class about the enzymes polyphenol oxidases, which have been shown to be responsible for the enzymatic browning of fruits and vegetables. Vegetables samples were submitted to enzymatic inactivation process with chemical reagents, as well as by bleaching methods of applying heat by conventional oven and microwave oven. Process efficiency was assessed qualitatively by both observing the guaiacol peroxidase activity and after the storage period under refrigeration or freezing. The practical results obtained in this class allow exploring multidisciplinary knowledge in food science, with practical applications in everyday life.

  8. Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders

    Directory of Open Access Journals (Sweden)

    So Hun Kim


    Full Text Available Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the field of the study of brown fat has gained great interest and is rapidly growing. Brown fat expansion and/or activation results in increased energy expenditure and a negative energy balance in mice and limits weight gain. Brown fat is also able to utilize blood glucose and lipid and results in improved glucose metabolism and blood lipid independent of weight loss. Prolonged cold exposure and beta adrenergic agonists can induce browning of white adipose tissue. The inducible brown adipocyte, beige adipocyte evolving by thermogenic activation of white adipose tissue have different origin and molecular signature from classical brown adipocytes but share the characteristics of high mitochondria content, UCP1 expression and thermogenic capacity when activated. Increasing browning may also be an efficient way to increase whole brown fat activity. Recent human studies have shown possibilities that findings in mice can be reproduced in human, making brown fat a good candidate organ to treat obesity and its related disorders.

  9. Brown dwarf disks with ALMA

    Energy Technology Data Exchange (ETDEWEB)

    Ricci, L.; Isella, A. [Department of Astronomy, California Institute of Technology, MC 249-17, Pasadena, CA 91125 (United States); Testi, L.; De Gregorio-Monsalvo, I. [European Southern Observatory, Karl-Schwarzschild-Strasse 2, D-85748 Garching (Germany); Natta, A. [INAF-Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy); Scholz, A., E-mail: [School of Cosmic Physics, Dublin Institute for Advanced Studies, 31 Fitzwilliam Place, Dublin 2 (Ireland)


    We present Atacama Large Millimeter/submillimeter Array continuum and spectral line data at 0.89 mm and 3.2 mm for three disks surrounding young brown dwarfs and very low mass stars in the Taurus star forming region. Dust thermal emission is detected and spatially resolved for all the three disks, while CO(J = 3-2) emission is seen in two disks. We analyze the continuum visibilities and constrain the disks' physical structure in dust. The results of our analysis show that the disks are relatively large; the smallest one has an outer radius of about 70 AU. The inferred disk radii, radial profiles of the dust surface density, and disk to central object mass ratios lie within the ranges found for disks around more massive young stars. We derive from our observations the wavelength dependence of the millimeter dust opacity. In all the three disks, data are consistent with the presence of grains with at least millimeter sizes, as also found for disks around young stars, and confirm that the early stages of the solid growth toward planetesimals occur also around very low-mass objects. We discuss the implications of our findings on models of solids evolution in protoplanetary disks, the main mechanisms proposed for the formation of brown dwarfs and very low-mass stars, as well as the potential of finding rocky and giant planets around very low-mass objects.

  10. The brain and brown fat. (United States)

    Contreras, Cristina; Gonzalez, Francisco; Fernø, Johan; Diéguez, Carlos; Rahmouni, Kamal; Nogueiras, Rubén; López, Miguel


    Brown adipose tissue (BAT) is a specialized organ responsible for thermogenesis, a process required for maintaining body temperature. BAT is regulated by the sympathetic nervous system (SNS), which activates lipolysis and mitochondrial uncoupling in brown adipocytes. For many years, BAT was considered to be important only in small mammals and newborn humans, but recent data have shown that BAT is also functional in adult humans. On the basis of this evidence, extensive research has been focused on BAT function, where new molecules, such as irisin and bone morphogenetic proteins, particularly BMP7 and BMP8B, as well as novel central factors and new regulatory mechanisms, such as orexins and the canonical ventomedial nucleus of the hypothalamus (VMH) AMP- activated protein kinase (AMPK)-SNS-BAT axis, have been discovered and emerged as potential drug targets to combat obesity. In this review we provide an overview of the complex central regulation of BAT and how different neuronal cell populations co-ordinately work to maintain energy homeostasis.

  11. Hey! A Brown Recluse Spider Bit Me! (United States)

    ... System Taking Care of Your Teeth Bad Breath Hey! A Brown Recluse Spider Bit Me! KidsHealth > For Kids > Hey! A Brown Recluse Spider Bit Me! Print A ... For Kids For Parents MORE ON THIS TOPIC Hey! A Fire Ant Stung Me! Hey! A Tarantula ...

  12. Microlensing Binaries with Candidate Brown Dwarf Companions

    DEFF Research Database (Denmark)

    Shin, I.-G; Han, C.; Gould, A.


    Brown dwarfs are important objects because they may provide a missing link between stars and planets, two populations that have dramatically different formation histories. In this paper, we present the candidate binaries with brown dwarf companions that are found by analyzing binary microlensing ...

  13. Remembering "Brown": Silence, Loss, Rage, and Hope (United States)

    Banks, James A.


    The author was in the seventh grade at the Newsome Training School in Aubrey, Arkansas when the Supreme Court handed down "Brown v. Board of Education" on May 17, 1954. His most powerful memory of the "Brown" decision is that he has no memory of it being rendered or mentioned by his parents, teachers, or preachers. In his rural…

  14. Isolation of glycoproteins from brown algae

    DEFF Research Database (Denmark)


    The present invention relates to a novel process for the isolation of unique anti-oxidative glycoproteins from the pH precipitated fractions of enzymatic extracts of brown algae. Two brown seaweeds viz, Fucus serratus and Fucus vesiculosus were hydrolysed by using 3 enzymes viz, Alcalase, Viscozyme...

  15. Brown vs. Board of Education Booklet




    This booklet was designed for K-12 classrooms and community groups examining the legacy of Brown v Board for California. The booklet chronicles the national battle for equal schooling up to and since the Brown decision. It also highlights the history of school segregation in California and the ongoing struggle for equal schooling.

  16. "Brown" and Black-White Achievement (United States)

    Armor, David J.


    "Brown v. Board of Education" only presumed to eliminate the "de jure" apartheid that existed in 1954. It was never intended to resolve the "de facto" gap in minority achievement that still faces education policymakers today. Sociologist David J. Armor goes beyond "Brown" to identify a set of definite risk…

  17. Brown recluse spider bite on the breast. (United States)

    Norris, Kori; Misra, Subhasis


    Brown recluse spiders are one of two types of spiders in the United States that can cause significant tissue damage and, in rare cases, death. Brown recluse spider bites are most often benign and self-limiting, but in a few cases can cause severe necrotic skin lesions.

  18. Some Aspects of Enzymatic Browning in Apples (United States)

    Liffen, C. L.; Cleeve, H. N.


    Describes material modified from the Nuffield advanced chemistry course to make it meaningful and relevant to pupils in the middle school. Discusses a series of simple experiments on apple browning and summarizes the browning process and its control. (Author/GS)

  19. Traumatic Brown-Séquard-plus syndrome. (United States)

    McCarron, M O; Flynn, P A; Pang, K A; Hawkins, S A


    In the 1840s Brown-Séquard described the motor and sensory effects of sectioning half of the spinal cord. Penetrating injuries can cause Brown-Séquard or, more frequently, Brown-Séquard-plus syndromes. To report the case of a 25-year-old man who developed left-sided Brown-Séquard syndrome at the C8 level and left-sided Horner syndrome plus urinary retention and bilateral extensor responses following a stab wound in the right side of the neck. Magnetic resonance imaging demonstrated a low cervical lesion and somatosensory evoked potentials confirmed the clinical finding of left-side dorsal column disturbance. At follow-up, the patient's mobility and bladder function had returned to normal. This patient recovered well after a penetrating neck injury that disturbed function in more than half the lower cervical spinal cord (Brown-Séquard-plus syndrome).

  20. Brown Swiss cattle cytogenetic analysis

    Directory of Open Access Journals (Sweden)

    Rita Maria Ladeira Pires


    Full Text Available At 1985, a Brown Swiss herd from the Institute of Animal Science and Pastures, APTA/ SAA was cytogenetically analyzed and 1/29 Robertsonian translocation was observed. Such anomaly is related to fertility reduction. Quimeric abnormality such as 60,XX/60,XY in freemartin females. This study aimed to evaluate the incidence of cromossomic abnormalities in Brown Swiss animals, descending form herd karyotyped earlier. After 25 years, 127 animals (97 females and 30 males from this herd were karyotyped by metaphases obtained from blood lymphocyte cultures. The typical diploid number 2n=60, 58 acrocentric and two X submetacentric chromosomes were confirmed in 94 females and in 27 males the sexual complement X and Y, both submetacentric, although from different sizes. Four females from gemelar parturition whit males were karyotyped. Three of them presented quimerism 60,XX/60,XY (one with 25.8% of female cells (XX and 74.2% male cells (XY; one another with 10% of cells XX e 90% of XY and the third with 50% of each type showing genital masculinization, diagnosed as freemartism and discarded from herd. Two hundred and five cells were analyzed from another female twins and only 60,XX cells were found, diagnosed as normal. His sister also were normal (60,XY. The another three males were also analyzed from gemelar heterosexual parturition, with karyotype 60,XX/60,XY. Cytogenetic analysis are a safe methodology for freemartin abnormalities identification in female bovine twins with male bovine, giving the opportunity of selecting fertile animals, avoiding loses in the management of sterile animals. Robertsonian’s translocation was not observed in any of the animals analyzed.

  1. Brown recluse spider bite to the eyelid. (United States)

    Jarvis, R M; Neufeld, M V; Westfall, C T


    To present a photographically documented case of a known brown recluse spider bite to the eyelid. Interventional case report. The wound was photographed daily during an 11-day hospitalization and at 1 month and 6 months after the injury. Treatment included canthotomy and cantholysis; administration of dapsone, antibiotics, and steroids; and hyperbaric oxygen therapy. Clinical presentation and course of a known brown recluse spider bite. Complete recovery with cicatrization at the site of the bite. We present a case of a brown recluse spider bite to the left lower eyelid with a discussion of management and outcome of this rarely reported injury.

  2. Progress report: brown bear studies - 1984 (United States)

    US Fish and Wildlife Service, Department of the Interior — Forty-four brown bears (22 adult female, 22 offspring) were captured in the Ayakulik River, Sturgeon River, and Frazer Lake drainages of Kodiak Island in July, 1983....

  3. Live-trapping and handling brown bear (United States)

    US Fish and Wildlife Service, Department of the Interior — In recent years bears have become increasingly important as big game animals. The brown bears (Ursus middendorfi) on the Kodiak National Wildlife Refuge, Kodiak...

  4. Brown bear telemetry and trapping: Special report (United States)

    US Fish and Wildlife Service, Department of the Interior — Brown bear studies were continued during the 1967 field season with emphasis on development of techniques for instrumenting bears with radio transmitters and...

  5. Seasonality of brown recluse populations is reflected by numbers of brown recluse envenomations. (United States)

    Rader, R K; Stoecker, W V; Malters, J M; Marr, M T; Dyer, J A


    A significant seasonal correlation was recently shown for brown recluse spider activity. Vetter (2011) observed brown recluse spiders were submitted by the general public predominantly during April-October. For patients with suspected brown recluse spider bites (BRSB), we have observed the same seasonality. Among 45 cases with features consistent of a BRSB, 43 (95.6%) occurred during April-October. Both the Vetter study and our study serve to demonstrate seasonal activity for brown recluse spiders. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. "If you thought this story sour, sweeten it with your own telling" - a feminist poetics of rewriting in Susan Price's Ghost dance

    Directory of Open Access Journals (Sweden)

    Sanna Lehtonen


    Full Text Available The attempts to challenge conventional gendered discourses in children's fantasy have often resulted in feminist rewritings of earlier stories. Ghost dance (1994 by the English author Susan Price is a novel that reflects a specific feminist poetics of rewriting: metafictional passages highlight the constructedness of the narrative and at the end readers are invited to tell their own versions of the story. Moreover, the rewriting freely combines and recontextualises elements from different source texts and reformulates them to create a narrative that challenges conventional discourses of gender. While this poetics has an appeal from a feminist perspective, the play with cross-cultural intertexts and gender becomes more complex when the novel is examined in a postcolonialist framework in relation to ethnicity and the issue of cultural appropriation. Ghost dance is situated in a setting that has a real-world equivalent (Russia, involves characters that are identified with names of real-world ethnic groups (Lapps (Sámi, Russian, and mixes elements from Russian wonder tales, Nordic mythology and an Ojibwe legend. The novel does not aim at historical accuracy in its representations nor is it a direct retelling of any of the pre-texts but combines motifs, themes, names, characters and settings freely from each source. In this textual melting pot, the protagonist Shingebiss is, on one level, a revision of the witch Baba Yaga, but also described as a Lappish shaman with an Ojibwe name. To rewrite gendered discourses, certain elements from the pretexts are chosen and others left out – the question is, then, what effects does this recontextualisation have on the representation of ethnicity? Or, are the feminist rewriting strategies actually a form of cultural appropriation?

  7. Lightning on exoplanets and brown dwarfs


    Hodosán, Gabriella


    Lightning is an important electrical phenomenon, known to exist in several Solar System planets. Amongst others, it carries information on convection and cloud formation, and may be important for pre-biotic chemistry. Exoplanets and brown dwarfs have been shown to host environments appropriate for the initiation of lightning discharges. In this PhD project, I aim to determine if lightning on exoplanets and brown dwarfs can be more energetic than it is known from Solar System planets, what are...

  8. Brown recluse spider bites: a case report. (United States)

    Nunnelee, Janice D


    The brown recluse spider is found more commonly in the Southeast and the Central Midwest. Its bite is not common because it is a shy spider that only bites if cornered. A severe bite may necrose a large area that requires skin grafting; systemic reactions rarely occur. This article discusses the brown recluse spider and presents a case study of a patient with two spider bites that did require extensive grafting.

  9. Ecological pellets from brown coal and biomass


    Pavel Sedláček; Nikolas Mucha; Iva Pečtová; Peter Fečko


    One way of renewable energy sources applications in the Czech republic is a cultivation of biomass plants. After the biomass reformation, it is possible to add it to palletizing mixes with coal and delulfurisative additives. Possibilities of brown coal of palletizing with biomass adds were tested recently. The product represents a new coal-biomass combustible wich can be used in some types of boilers with a low pollutant production level (specially SO2).In the past brown-coal pellets weremade...

  10. European brown hare syndrome virus in free-ranging European brown hares from Argentina

    DEFF Research Database (Denmark)

    Frolich, K.; Kujawski, G.E.J.G.; Rudolph, M.


    From 1998 to 2000, serum samples of 80 shot European brown hares (Lepus europaeus) from Argentina were examined for antibodies against European brown hare syndrome virus (EBHSV) and 80 spleen samples were tested for EBHSV-antigen by enzyme linked immunosorbent assay (ELISA). Nine hares were...

  11. Idufirma Silicon Valleyta / Susan Adams

    Index Scriptorium Estoniae

    Adams, Susan


    Tarkvarafirma Apprenda toodab teenindusplatvormi tarkvara, mis võimaldab klientidel luua ja hoida käigus uusi mobiilseid ja pilvetehnoloogiapõhiseid rakendusi. Oma töötajatele pakub odavaid elamispindu ja madalaid makse

  12. Temperatures rising: brown fat and bone. (United States)

    Motyl, Katherine J; Rosen, Clifford J


    Caloric restriction is associated with a reduction in body weight and temperature, as well as a reduction in trabecular bone volume and paradoxically an increase in adipocytes within the bone marrow. The nature of these adipocytes is uncertain, although there is emerging evidence of a direct relationship between bone remodeling and brown adipocytes. For example, in heterotrophic ossification, brown adipocytes set up a hypoxic gradient that leads to vascular invasion, chondrocyte differentiation, and subsequent bone formation. Additionally, deletion of retinoblastoma protein in an osteosarcoma model leads to increased hibernoma (brown fat tumor). Brown adipose tissue (BAT) becomes senescent with age at a time when thermoregulation is altered, bone loss becomes apparent, and sympathetic activity increases. Interestingly, heart rate is an unexpected but good predictor of fracture risk in elderly individuals, pointing to a key role for the sympathetic nervous system in senile osteoporosis. Hence the possibility exists that BAT could play an indirect role in age-related bone loss. However, evidence of an indirect effect from thermogenic dysfunction on bone loss is currently limited. Here, we present current evidence for a relationship between brown adipose tissue and bone as well as provide novel insights into the effects of thermoregulation on bone mineral density.

  13. The colored Hanbury Brown-Twiss effect (United States)

    Silva, B.; Sánchez Muñoz, C.; Ballarini, D.; González-Tudela, A.; de Giorgi, M.; Gigli, G.; West, K.; Pfeiffer, L.; Del Valle, E.; Sanvitto, D.; Laussy, F. P.


    The Hanbury Brown-Twiss effect is one of the celebrated phenomenologies of modern physics that accommodates equally well classical (interferences of waves) and quantum (correlations between indistinguishable particles) interpretations. The effect was discovered in the late thirties with a basic observation of Hanbury Brown that radio-pulses from two distinct antennas generate signals on the oscilloscope that wiggle similarly to the naked eye. When Hanbury Brown and his mathematician colleague Twiss took the obvious step to propose bringing the effect in the optical range, they met with considerable opposition as single-photon interferences were deemed impossible. The Hanbury Brown-Twiss effect is nowadays universally accepted and, being so fundamental, embodies many subtleties of our understanding of the wave/particle dual nature of light. Thanks to a novel experimental technique, we report here a generalized version of the Hanbury Brown-Twiss effect to include the frequency of the detected light, or, from the particle point of view, the energy of the detected photons. Our source of light is a polariton condensate, that allows high-resolution filtering of a spectrally broad source with a high degree of coherence. In addition to the known tendencies of indistinguishable photons to arrive together on the detector, we find that photons of different colors present the opposite characteristic of avoiding each others. We postulate that fermions can be similarly brought to exhibit positive (boson-like) correlations by frequency filtering.

  14. Radial Velocity Variability of Field Brown Dwarfs (United States)

    Prato, L.; Mace, G. N.; Rice, E. L.; McLean, I. S.; Kirkpatrick, J. Davy; Burgasser, A. J.; Kim, Sungsoo S.


    We present paper six of the NIRSPEC Brown Dwarf Spectroscopic Survey, an analysis of multi-epoch, high-resolution (R ˜ 20,000) spectra of 25 field dwarf systems (3 late-type M dwarfs, 16 L dwarfs, and 6 T dwarfs) taken with the NIRSPEC infrared spectrograph at the W. M. Keck Observatory. With a radial velocity (RV) precision of ˜2 km s-1, we are sensitive to brown dwarf companions in orbits with periods of a few years or less given a mass ratio of 0.5 or greater. We do not detect any spectroscopic binary brown dwarfs in the sample. Given our target properties, and the frequency and cadence of observations, we use a Monte Carlo simulation to determine the detection probability of our sample. Even with a null detection result, our 1σ upper limit for very low mass binary frequency is 18%. Our targets included seven known, wide brown dwarf binary systems. No significant RV variability was measured in our multi-epoch observations of these systems, even for those pairs for which our data spanned a significant fraction of the orbital period. Specialized techniques are required to reach the high precisions sensitive to motion in orbits of very low-mass systems. For eight objects, including six T dwarfs, we present the first published high-resolution spectra, many with high signal to noise, that will provide valuable comparison data for models of brown dwarf atmospheres.

  15. Whither do the microlensing Brown Dwarfs rove?

    CERN Document Server

    De Rújula, Alvaro; Mollerach, S; Roulet, Esteban; de Rujula, A; Giudice, G; Mollerach, S; Roulet, E


    The EROS and MACHO collaborations have reported observations of light curves of stars in the Large Magellanic Cloud that are compatible with gravitational microlensing by intervening massive objects, presumably Brown-Dwarf stars. The OGLE and MACHO teams have also seen similar events in the direction of the galactic Bulge. Current data are insufficient to decide whether the Brown-Dwarfs are dark-matter constituents of the non-luminous galactic Halo, or belong to a more conventional population, such as that of faint stars in the galactic Spheroid, in its Thin or Thick Disks, or in their possible LMC counterparts. We discuss in detail how further observations of microlensing rates and of the moments of the distribution of event durations, can help resolve the issue of the Brown-Dwarf location, and eventually provide information on the mass function of the dark objects.

  16. Epidemiology of the brown recluse spider bite. (United States)

    Rhoads, Jacqueline


    The purpose of this article was to provide a comprehensive epidemiological and clinical description of the brown recluse spider bite. Review of evidenced-based scientific literature and practice guidelines. A specific descriptive case study is interwoven through the article to tie in the clinical presenting figure associated with this bite. The brown recluse lives in a circumscribed area of the United States (the south central Midwest) with a few less common recluse species living in the more sparsely populated southwest United States. In these areas, where spider populations may be dense, recluse spiders may be a cause of significant morbidity. Most spider bites are asymptomatic but what makes this bite so devastating is the toxin injected by the brown recluse spider, which can cause considerable systemic symptoms as well as necrotic skin ulcers (necrotic arachnidism). The article presents process for diagnosis and stresses the importance of identifying the spider if at all possible.

  17. Novel nuances of human brown fat

    DEFF Research Database (Denmark)

    Scheele, Camilla; Larsen, Therese Juhlin; Nielsen, Søren


    There is a current debate in the literature on whether human fat derived from the supraclavicular region should be classified as brown, or as the white fat-derived less potent, brite/beige. This commentary addresses whether the existing classification defined in mice is sufficient to describe...... the types of thermogenic adipocytes in humans. We recently published a contradictory mRNA expression signature of human supraclavicular fat defined by an upregulation of the brite marker TBX1 along with the classical brown markers ZIC1 and LHX8, as well as genes indicating brown fat activity including UCP1......, PGC-1α, and PRDM16; and, finally, a downregulation of the white/brite markers HOXC8 and HOXC9. Subcutaneous fat was used as reference material. Another recent study presents a higher expression of ZIC1 and a lower expression of TBX1 in interscapular compared with supraclavicular fat. Here, however...

  18. Brown adipogenesis of mouse embryonic stem cells in alginate microstrands (United States)

    Unser, Andrea Mannarino

    The ability of brown adipocytes (fat cells) to dissipate energy as heat shows great promise for the treatment of obesity and other metabolic disorders. Employing pluripotent stem cells, with an emphasis on directed differentiation, may overcome many issues currently associated with primary fat cell cultures. However, brown adipocytes are difficult to transplant in vivo due to the instability of fat, in terms of necrosis and neovascularization, once injected. Thus, 3D cell culture systems that have the potential to mimic adipogenic microenvironments are needed, not only to advance brown fat implantation, but also to better understand the role of brown adipocytes in treating obesity. To address this need, we created 3D "Brown-Fat-in-Microstrands" by microfluidic synthesis of alginate hydrogel microstrands that encapsulated cells and directly induced cell differentiation into brown adipocytes, using mouse embryonic stem cells (ESCs) as a model of pluripotent stem cells and brown preadipocytes as a positive control. The effect of hydrogel formation parameters on brown adipogenesis was studied, leading to the establishment of "Brown-Fat-in-Microstrands". Brown adipocyte differentiation within microstrands was confirmed by lipid droplet accumulation, immunocytochemistry and qPCR analysis of gene expression of brown adipocyte marker uncoupling protein 1 (UCP1) in addition to adipocyte marker expression. Compared to a 2D approach, 3D differentiated "Brown-Fat-in-Microstrands" exhibited higher level of brown adipocyte marker expression. The functional analysis of "Brown-Fat-in-Microstrands" was attempted by measuring the mitochondrial activity of ESC-differentiated brown adipocytes in 3D using Seahorse XF24 3 Extracellular Flux Analyzer. The ability to create "Brown-Fat-in-Microstrands" from pluripotent stem cells opens up a new arena to understanding brown adipogenesis and its implications in obesity and metabolic disorders.

  19. Hanbury Brown-Twiss interference of anyons. (United States)

    Campagnano, Gabriele; Zilberberg, Oded; Gornyi, Igor V; Feldman, Dmitri E; Potter, Andrew C; Gefen, Yuval


    We present a study of a Hanbury Brown-Twiss interferometer realized with anyons. Such a device can directly probe entanglement and fractional statistics of initially uncorrelated particles. We calculate Hanbury Brown-Twiss cross correlations of Abelian Laughlin anyons. The correlations we calculate exhibit partial bunching similar to bosons, indicating a substantial statistical transmutation from the underlying electronic degrees of freedom. We also find qualitative differences between the anyonic signal and the corresponding bosonic or fermionic signals, indicating that anyons cannot be simply thought of as intermediate between bosons and fermions.

  20. Briquetting of Coke-Brown Coal Mixture

    Directory of Open Access Journals (Sweden)

    Ïurove Juraj


    Full Text Available The paper presents the results of the research of briquetting a coke-brown coal composite The operation consists of the feeding crushed coal and coke to moulds and pressing into briquettes which have been made in the Laboratories at the Mining Faculty of Technical University of Košice (Slovakia. In this research, all demands will be analyzed including the different aspects of the mechanical quality of briquettes, the proportion of fine pulverulent coal and coke in bricks, the requirements for briquetting the coke-brown coal materials.

  1. Kodiak brown bear population on Kodiak Island, Alaska (United States)

    US Fish and Wildlife Service, Department of the Interior — Methods and estimates of the Brown bear population on Kodiak Island. The total number of Kodiak Brown Bears on Kodiak Island has been estimated to be 1669. Three...

  2. Trustworthy-looking face meets brown eyes.

    Directory of Open Access Journals (Sweden)

    Karel Kleisner

    Full Text Available We tested whether eye color influences perception of trustworthiness. Facial photographs of 40 female and 40 male students were rated for perceived trustworthiness. Eye color had a significant effect, the brown-eyed faces being perceived as more trustworthy than the blue-eyed ones. Geometric morphometrics, however, revealed significant correlations between eye color and face shape. Thus, face shape likewise had a significant effect on perceived trustworthiness but only for male faces, the effect for female faces not being significant. To determine whether perception of trustworthiness was being influenced primarily by eye color or by face shape, we recolored the eyes on the same male facial photos and repeated the test procedure. Eye color now had no effect on perceived trustworthiness. We concluded that although the brown-eyed faces were perceived as more trustworthy than the blue-eyed ones, it was not brown eye color per se that caused the stronger perception of trustworthiness but rather the facial features associated with brown eyes.

  3. Natural history of presumed congenital Brown syndrome. (United States)

    Kaban, T J; Smith, K; Orton, R B; Noel, L P; Clarke, W; Cadera, W


    To evaluate the stability of the ocular alignment in patients with presumed congenital Brown syndrome. A retrospective review of patients with Brown syndrome with an emphasis on nonsurgical cases. Follow-up of at least 1 year was required for inclusion in the study. Patients were selected for this study from the pediatric ophthalmology services at the Ivey Institute of Ophthalmology, London, Ontario, and the Children's Hospital of Eastern Ontario, Ottawa. A cohort of 71 patients with presumed congenital Brown syndrome. Two cases were bilateral. Eleven cases were excluded because of insufficient length of follow-up, leaving 60 patients with an average follow-up of 46 months. All patients were assessed and followed up by a pediatric ophthalmologist. Of 38 patients who had no hypotropia in primary position at presentation, only two (5%) patients experienced a worsening with the development of a small vertical strabismus during the follow-up period. Six (10%) of the entire group of 60 patients experienced a complete spontaneous resolution of the deficiency in elevation at 4, 6, 8, 10, 12, and 15 years of age. Among patients with congenital Brown syndrome, those who are orthotropic in the primary position tend to remain stable or improve over time without surgical intervention.

  4. Brown Bodies, Racialisation and physical education (United States)

    Fitzpatrick, Katie


    This article explores how school physical education (PE) can both reinforce stereotyped notions of the brown body as inherently physical while also allowing young people to gain educational success. Drawing on a critical ethnographic study of Maori and Pasifika (Pacific Island) youth in PE in New Zealand, the article explores how the academic…

  5. Maxillary brown tumour: unusual presentation of parathyroid ...

    African Journals Online (AJOL)

    This is a report of a maxillary brown tumour caused by primary hyperparathyroidism (HPT) secondary to parathyroid carcinoma. A 62-year-old man presented with a large swelling in the right maxilla, which caused right-sided nasal obstruction, intermittent bleeding and diplopia. A computed tomography scan demonstrated ...

  6. Molecular Selectivity of Brown Carbon Chromophores

    Energy Technology Data Exchange (ETDEWEB)

    Laskin, Julia; Laskin, Alexander; Nizkorodov, Sergey; Roach, Patrick J.; Eckert, Peter A.; Gilles, Mary K.; Wang, Bingbing; Lee, Hyun Ji; Hu, Qichi


    Complementary methods of high-resolution mass spectrometry and micro-spectroscopy were utilized for molecular analysis of secondary organic aerosol (SOA) generated from ozonolysis of two structural monoterpene isomers: D-limonene (LSOA) and a-pinene (PSOA). Laboratory simulated aging of LSOA and PSOA, through conversion of carbonyls into imines mediated by NH3 vapors in humid air, resulted in selective browning of the LSOA sample, while the PSOA sample remained white. Comparative analysis of the reaction products in the aged LSOA and PSOA samples provided insights into chemistry relevant to formation of brown carbon chromophores. A significant fraction of carbonyl-imine conversion products with identical molecular formulas were detected in both samples. This reflects the high level of similarity in the molecular composition of these two closely related SOA materials. Several highly conjugated products were detected exclusively in the brown LSOA sample and were identified as potential chromophores responsible for the observed color change. The majority of the unique products in the aged LSOA sample with the highest number of double bonds contain two nitrogen atoms. We conclude that chromophores characteristic of the carbonyl- imine chemistry in LSOA are highly conjugated oligomers of secondary imines (Schiff bases) present at relatively low concentrations. Formation of this type of conjugated compounds in PSOA is hindered by the structural rigidity of the a-pinene oxidation products. Our results suggest that the overall light-absorbing properties of SOA may be determined by trace amounts of strong brown carbon chromophores.

  7. The browning of Alaska's boreal forest (United States)

    Mary Beth Parent; David. Verbyla


    We used twelve Landsat scenes from the 1980s-2009 and regional 2000-2009 MODIS data to examine the long-term trend in the normalized difference vegetation index (NDVI) within unburned areas of the Alaskan boreal forest. Our analysis shows that there has been a declining trend in NDVI in this region, with the strongest "browning trend" occurring in eastern...

  8. Phospholipids of New Zealand Edible Brown Algae. (United States)

    Vyssotski, Mikhail; Lagutin, Kirill; MacKenzie, Andrew; Mitchell, Kevin; Scott, Dawn


    Edible brown algae have attracted interest as a source of beneficial allenic carotenoid fucoxanthin, and glyco- and phospholipids enriched in polyunsaturated fatty acids. Unlike green algae, brown algae contain no or little phosphatidylserine, possessing an unusual aminophospholipid, phosphatidyl-O-[N-(2-hydroxyethyl) glycine], PHEG, instead. When our routinely used technique of 31P-NMR analysis of phospholipids was applied to the samples of edible New Zealand brown algae, a number of signals corresponding to unidentified phosphorus-containing compounds were observed in total lipids. NI (negative ion) ESI QToF MS spectra confirmed the presence of more familiar phospholipids, and also suggested the presence of PHEG or its isomers. The structure of PHEG was confirmed by comparison with a synthetic standard. An unusual MS fragmentation pattern that was also observed prompted us to synthesise a number of possible candidates, and was found to follow that of phosphatidylhydroxyethyl methylcarbamate, likely an extraction artefact. An unexpected outcome was the finding of ceramidephosphoinositol that has not been reported previously as occurring in brown algae. An uncommon arsenic-containing phospholipid has also been observed and quantified, and its TLC behaviour studied, along with that of the newly synthesised lipids.

  9. Brown hares on the edge: Genetic population structure of the Danish brown hare

    DEFF Research Database (Denmark)

    Andersen, Liselotte W.; Fredsted, Tina; Wincentz, Trine


    Andersen L. W., Fredsted T., Wincentz T. and Pertoldi C. 2009. Brown hares on the edge: Genetic population structure of the Danish brown hare. Acta Theriologica 54: 97-110. Denmark lies on the edge of the distributional range of the brown hare Lepus europaeus Pallas, 1778, where population......-69.8 respectively). There was no correlation between the geographic and the genetic distance. Population structure was influenced by genetic drift, anthropogenic effects (eg translocation and escapes from hare-farms) and by post-glacial recolonization from southern refuges or refuges north east of the Black Sea...... glaciations or by stocking effects. Colonization from southern refuges was supported by the observation that haplotype 2 in the Danish brown hare was identical to the central European ancestral haplotype c07....

  10. Kenai Peninsula Brown Bear Studies : Report of the Interagency Brown Bear Study Team, 1986 (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes work conducted during the 1986 field season on brown bear (Ursus arctos) from the Kenai Peninsula, Alaska. Ground surveys were conducted to...

  11. Gas exchange and brown heart in conference pears

    NARCIS (Netherlands)

    Otma, E.C.; Peppelenbos, H.W.


    Brown heart is a tissue disorder found in Conference pears during CA storage. Differences in susceptibility for brown heart have been found between countries, orchards, harvest dates and storage conditions. One hypothesis is that brown heart is caused by increased internal CO2. This research

  12. 49 CFR 173.216 - Asbestos, blue, brown or white. (United States)


    ... 49 Transportation 2 2010-10-01 2010-10-01 false Asbestos, blue, brown or white. 173.216 Section... Class 7 § 173.216 Asbestos, blue, brown or white. (a) Asbestos, blue, brown or white, includes each of the following hydrated mineral silicates: chrysolite, crocidolite, amosite, anthophyllite asbestos...

  13. Simulationsverfahren fuer Brown-Resnick-Prozesse (Simulation Techniques for Brown-Resnick Processes)


    Oesting, Marco


    Generalized Brown-Resnick processes form a flexible class of stationary max-stable processes based on Gaussian random fields. With regard to applications fast and accurate simulation of these processes is an important issue. In fact, Brown-Resnick processes that are generated by a dissipative flow do not allow for good finite approximations using the definition of the processes. On large intervals we get either huge approximation errors or very long operating times. Looking for solutions of t...

  14. Mandibular brown tumor in renal osteodystrophy

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Woo; Choi, Bo Ram; Huh, Kyung Hoe; Yi, Won Jin; Choi, Soon Chul [Department of Oral and Maxillofacial Radiology, School of Dentistry, Seoul National University, Seoul (Korea, Republic of); Gang, In Tae [Department of Oral and Maxillofacial Surgery, Kangnam Sacred Heart Hospital, Hallym Medical Center, Seoul (Korea, Republic of)


    Brown tumor is a histologically benign lesion that is a serious complication of renal osteodystrophy because it may result in severe deformity and discomfort. We report a case of brown tumor, which occurred in a 35-year-old woman with chronic renal failure, who had been treated with hemodialysis for 14 years. The lesion was found on the lingual side of the mandible. Standard panoramic radiograph showed generally decreased bone mineral density, loss of lamina dura, and thin cortical plates. Computed tomography (CT) revealed multilocular expansible lesions with heterogeneous attenuation in the anterior mandible, as well as generalized trabecular alteration with homogeneous sclerosis, and thinning or obliteration of cortical plates. Excision of the mandibular lesion and curettage of the affected bone were performed.

  15. Identifying and misidentifying the brown recluse spider. (United States)

    Vetter, R


    The brown recluse spider, Loxosceles reclusa, is often implicated as a cause of necrotic skin lesions.[1-3] Diagnoses are most commonly made by clinical appearance and infrequently is a spider seen, captured or identified at the time of the bite.[1, 2, 4-6] The brown recluse lives in a circumscribed area of the U.S. (the south central Midwest) with a few less common recluse species living in the more sparsely-populated southwest U.S.[7] In these areas, where spider populations may be dense, recluse spiders may be a cause of significant morbidity. However, outside the natural range of these recluse species, the conviction that they are the etiological agents behind necrotic lesions of unknown origin is widespread, and most often erroneous. In some states such as California, unsubstantiated reports concerning recluse spider bites have taken on the status of "urban legend" leading to overdiagnosis and, therefore, inappropriate treatment.

  16. Histological findings after brown recluse spider envenomation. (United States)

    Elston, D M; Eggers, J S; Schmidt, W E; Storrow, A B; Doe, R H; McGlasson, D; Fischer, J R


    Histologic specimens from 41 rabbits were studied for changes resulting from the manual injection of brown recluse spider venom. Major findings included a mixed inflammatory cell infiltrate, coagulative tissue necrosis, and vasculitis. All specimens demonstrated a well-delineated zone of eosinophilic staining recognizable as "mummified" coagulative necrosis of the epidermis and dermis. A dense band of neutrophils bordered the zone of necrosis. Immediately adjacent to the neutrophilic band, small vessel vasculitis was a universal finding. Degranulated eosinophils and neutrophils and macrophages filled with eosinophilic granules were common. Inflammatory foci were often centered on groups of lipocytes within the dermis. Large vessel vasculitis resembling that seen in polyarteritis nodosa was present deep to 7 of the 40 eschars. Large vessel vasculitis may contribute to the large zones of necrosis seen after some brown recluse spider bites. Eosinophils may play a role in tissue damage after envenomation.

  17. Thermodynamic study of brown-coal gasification

    Energy Technology Data Exchange (ETDEWEB)

    Vonka, P.; Holub, R.; Schoengut, S.; Schoengut, J.


    Describes a method for calculating and assessing results of partial adiabatic oxidation of brown coal from the North Bohemian brown-coal field, which may in future act as a source of raw material for production of energy and synthesis gas. Calculations assume idealized fluid and burner generators and reaction parameters were selected to cover a range of operational values (these parameters include pressure, temperature, gasification ratio, water content, ash content and degree of coal conversion). After describing mathematics involved, concludes that thermodynamic analysis shows burner generator to have some advantages over fluid generator for production of synthesis gas, and vice versa for production of energy gas. However, final conclusions must await experimental evidence with regard to degree of conversion and composition of gas mixture; also, validity of this assessment is limited by the fact that no account was taken of the possibility of using reaction heat for production of steam or of any energy consumption involved. 10 refs.

  18. Ecological pellets from brown coal and biomass

    Directory of Open Access Journals (Sweden)

    Pavel Sedláček


    Full Text Available One way of renewable energy sources applications in the Czech republic is a cultivation of biomass plants. After the biomass reformation, it is possible to add it to palletizing mixes with coal and delulfurisative additives. Possibilities of brown coal of palletizing with biomass adds were tested recently. The product represents a new coal-biomass combustible wich can be used in some types of boilers with a low pollutant production level (specially SO2.In the past brown-coal pellets weremade with an addition of melted wood mass (wood fibres, wood wastes and mustard straw. Practical tests have shown of an extension the waste field of coal-pellets utilization.

  19. Deterministic remote preparation via the Brown state (United States)

    Ma, Song-Ya; Gao, Cong; Zhang, Pei; Qu, Zhi-Guo


    We propose two deterministic remote state preparation (DRSP) schemes by using the Brown state as the entangled channel. Firstly, the remote preparation of an arbitrary two-qubit state is considered. It is worth mentioning that the construction of measurement bases plays a key role in our scheme. Then, the remote preparation of an arbitrary three-qubit state is investigated. The proposed schemes can be extended to controlled remote state preparation (CRSP) with unit success probabilities. At variance with the existing CRSP schemes via the Brown state, the derived schemes have no restriction on the coefficients, while the success probabilities can reach 100%. It means the success probabilities are greatly improved. Moreover, we pay attention to the DRSP in noisy environments under two important decoherence models, the amplitude-damping noise and phase-damping noise.

  20. [Cancer cachexia and white adipose tissue browning]. (United States)

    Zhang, S T; Yang, H M


    Cancer cachexia occurs in a majority of advanced cancer patients. These patients with impaired physical function are unable to tolerance cancer treatment well and have a significantly reduced survival rate. Currently, there is no effective clinical treatment available for cancer cachexia, therefore, it is necessary to clarify the molecular mechanisms of cancer cachexia, moreover, new therapeutic targets for cancer cachexia treatment are urgently needed. Very recent studies suggest that, during cancer cachexia, white adipose tissue undergo a 'browning' process, resulting in increased lipid mobilization and energy expenditure, which may be necessary for the occurrence of cancer cachexia. In this article, we summarize the definition and characteristics of cancer cachexia and adipose tissue 'browning', then, we discuss the new study directions presented in latest research.

  1. Browning boreal forests of western North America (United States)

    David. Verbyla


    The GIMMS NDVI dataset has been widely used to document a “browning trend” in North American boreal forests (Goetz et al. 2005, Bunn et al. 2007, Beck and Goetz 2011). However, there has been speculation (Alcaraz-Segura et al. 2010) that this trend may be an artifact due to processing algorithms rather than an actual decline in vegetation activity. This conclusion was...

  2. Finding Brown's peony a sweet attraction (United States)

    Nan. Vance


    I first encountered Brown’s peony (Paeonia brownie) with its verdant, lavender-tinged leaves and elegantly nodding maroon flowers growing among bitterbrush and bunchgrass on the eastern flank of the Oregon Cascades. My first thought was “What is a plant like you doing in a place like this?” It would be natural to visualize this native wild peony as...

  3. Drivers of hibernation in the brown bear


    Evans, Alina; Singh, N.J.; Friebe, A.; Arnemo, Jon M.; Laske, T.G.; Fröbert, O.; Swenson, Jon E.; Blanc, S.


    Background Hibernation has been a key area of research for several decades, essentially in small mammals in the laboratory, yet we know very little about what triggers or ends it in the wild. Do climatic factors, an internal biological clock, or physiological processes dominate? Using state-of-the-art tracking and monitoring technology on fourteen free-ranging brown bears over three winters, we recorded movement, heart rate (HR), heart rate variability (HRV), body temperature (Tb), physical a...

  4. New brown dwarf candidates in the Pleiades (United States)

    Eisenbeiss, T.; Moualla, M.; Mugrauer, M.; Schmidt, T. O. B.; Raetz, St.; Neuhäuser, R.; Ginski, Ch.; Hohle, M. M.; Koeltzsch, A.; Marka, C.; Rammo, W.; Reithe, A.; Roell, T.; Vaňko, M.


    We have performed deep, wide-field imaging on a ˜ 0.4 deg2 field in the Pleiades (Melotte 22). The selected field was not yet target of a deep search for low mass stars and brown dwarfs. Our limiting magnitudes are R˜22 mag and I˜20 mag, sufficient to detect brown dwarf candidates down to 40 MJ. We found 197 objects, whose location in the (I, R-I) color magnitude diagram is consistent with the age and the distance of the Pleiades. Using CTK R and I as well as JHK photometry from our data and the 2MASS survey we were able to identify 7 new brown dwarf candidates. We present our data reduction technique, which enables us to resample, calibrate, and co-add many images by just two steps. We estimate the interstellar extinction and the spectral type from our optical and the NIR data using a two-dimensional χ2 fitting. Based on observations obtained with telescopes of the University Observatory Jena, which is operated by the Astrophysical Institute of the Friedrich- Schiller-University. Table A3 is available at the CDS via

  5. Disintegration of brown coal using alkaline solution

    Energy Technology Data Exchange (ETDEWEB)

    Vydra, J.; Skalicka, J.


    Investigations carried out by the Institute of Geology and Geotechnics of the Academy of Sciences of Czechoslovakia are discussed. The investigations were aimed at determining the optimum conditions for in situ solution mining of brown coal using alkaline solutions. Twelve brown coal samples with carbon content ranging from 64.5 to 90.7% were treated with sodium hydroxide solution with concentration ranging from 1 to 5%. Effects of hydrogen peroxide (15%) and ethanolamine (5%) also were investigated. Proportion of the 3 compounds in water was the following: 500 ml sodium hydroxide, 100 ml ethanolamine and 20 ml hydrogen peroxide. Effects of coal grain size on its disintegration in the alkaline solution also were analyzed. Conditions of in situ solution mining were simulated in the laboratory. Investigations showed that the optimum coal grain size was 2 mm, in which case disintegration efficiency depended on carbon content in coal. The lower the carbon content was, the more efficient was the alkaline disintegration. Alkaline solutions did not influence brown coal with carbon content higher than 85%. The optimum concentration of sodium hydroxide was 3%. Addition of hydrogen peroxide and ethanolamine did not influence disintegration. When alkaline solution was pumped 96 h long into a borehole, it penetrated coal to a depth of 2 mm causing swelling of the borehole walls but not coal disintegration. 8 references.

  6. Cannabidiol promotes browning in 3T3-L1 adipocytes. (United States)

    Parray, Hilal Ahmad; Yun, Jong Won


    Recruitment of the brown-like phenotype in white adipocytes (browning) and activation of existing brown adipocytes are currently being investigated as a means to combat obesity. Thus, a wide variety of dietary agents that contribute to browning of white adipocytes have been identified. The present study was designed to investigate the effects of cannabidiol (CBD), a major nonpsychotropic phytocannabinoid of Cannabis sativa, on induction of browning in 3T3-L1 adipocytes. CBD enhanced expression of a core set of brown fat-specific marker genes (Ucp1, Cited1, Tmem26, Prdm16, Cidea, Tbx1, Fgf21, and Pgc-1α) and proteins (UCP1, PRDM16, and PGC-1α). Increased expression of UCP1 and other brown fat-specific markers contributed to the browning of 3T3-L1 adipocytes possibly via activation of PPARγ and PI3K. In addition, CBD increased protein expression levels of CPT1, ACSL, SIRT1, and PLIN while down-regulating JNK2, SREBP1, and LPL. These data suggest possible roles for CBD in browning of white adipocytes, augmentation of lipolysis, thermogenesis, and reduction of lipogenesis. In conclusion, the current data suggest that CBD plays dual modulatory roles in the form of inducing the brown-like phenotype as well as promoting lipid metabolism. Thus, CBD may be explored as a potentially promising therapeutic agent for the prevention of obesity.

  7. Influence of selected factors on browning of Camembert cheese. (United States)

    Carreira, Alexandra; Dillinger, Klaus; Eliskases-Lechner, Frieda; Loureiro, Virgílio; Ginzinger, Wolfgang; Rohm, Harald


    Experimental Camembert cheeses were made to investigate the effects on browning of the following factors: inoculation with Yarrowia lipolytica, the use of Penicillium candidum strains with different proteolytic activity, the addition of tyrosine, and the addition of Mn2+ thus leading to 16 different variants of cheese. Two physical colour parameters were used to describe browning, depending on the location in the cheeses: a whiteness index for the outside browning (mould mycelium), and a brownness index for the inside browning (surface of the cheese body). Mn2+ promoted a significant increase of browning at both locations, whereas Yar. lipolytica had the opposite effect. Outside browning was significantly more intense when using the Pen. candidum strain with higher proteolytic activity. A significant interaction was found between Yar. lipolytica and Pen. candidum. The yeast had no effect in combination with a low proteolytic strain of Pen. candidum, but significantly reduced proteolysis and browning in combination with a high proteolytic strain of Pen. candidum. We further confirmed that both strains of Pen. candidum were able to produce brown pigments from tyrosine and thus both are presumably responsible for the browning activity in this type of cheese.

  8. Generalised Brown Clustering and Roll-up Feature Generation

    DEFF Research Database (Denmark)

    Derczynski, Leon; Chester, Sean


    Brown clustering is an established technique, used in hundreds of computational linguistics papers each year, to group word types that have similar distributional information. It is unsupervised and can be used to create powerful word representations for machine learning. Despite its improbable...... success relative to more complex methods, few have investigated whether Brown clustering has really been applied optimally. In this paper, we present a subtle but profound generalisation of Brown clustering to improve the overall quality by decoupling the number of output classes from the computational...... active set size. Moreover, the generalisation permits a novel approach to feature selection from Brown clusters: We show that the standard approach of shearing the Brown clustering output tree at arbitrary bitlengths is lossy and that features should be chosen instead by rolling up Generalised Brown...

  9. Genetic backgrounds determine brown remodeling of white fat in rodents


    Ferrannini, Giulia; Namwanje, Maria; Fang, Bin; Damle, Manashree; Li, Dylan; Liu, Qiongming; Lazar, Mitchell A.; Qiang, Li


    Objective: Genetic background largely contributes to the complexity of metabolic responses and dysfunctions. Induction of brown adipose features in white fat, known as brown remodeling, has been appreciated as a promising strategy to offset the positive energy balance in obesity and further to improve metabolism. Here we address the effects of genetic background on this process. Methods: We investigated browning remodeling in a depot-specific manner by comparing the response of C57BL/6J, 1...

  10. Study on enzymatic browning in suspension cultures of licorice cells


    Yali Li; Tingting Meng; Yuxi Wang; Xiaoli Zhang


    Enzymatic browning is one of the main obstacles encountered in the establishment of suspension systems of licorice cells. Browning of cells may result in decreased viability, poor growth and even death. The present study investigated the mechanism of browning reactions and the effective controlling methods. The results showed that the cell viability and membrane permeabilization obviously changed when the cells were transferred to liquid medium. The transformation caused rapid increase in the...

  11. Regulation of glycolysis in brown adipocytes by HIF-1α

    DEFF Research Database (Denmark)

    Basse, Astrid L; Isidor, Marie S; Winther, Sally


    Brown adipose tissue takes up large amounts of glucose during cold exposure in mice and humans. Here we report an induction of glucose transporter 1 expression and increased expression of several glycolytic enzymes in brown adipose tissue from cold-exposed mice. Accordingly, these genes were also...... with glucose as the only exogenously added fuel. These data suggest that HIF-1α-dependent regulation of glycolysis is necessary for maximum glucose metabolism in brown adipocytes....

  12. Obituary: Beth Brown (1969-2008) (United States)

    Bregman, Joel


    The astronomical community lost one of its most buoyant and caring individuals when Beth Brown died, unexpectedly, at the age of 39 from a pulmonary embolism. Beth Brown was born in Roanoke, Virginia where she developed a deep interest in astronomy, science, and science fiction (Star Trek). After graduating as the valedictorian of William Fleming High School's Class of 1987, she attended Howard University, where she graduated summa cum laude in 1991 with a bachelor's degree in astrophysics. Following a year in the graduate physics program at Howard, she entered the graduate program in the Department of Astronomy at the University of Michigan, the first African-American woman in the program. She received her PhD in 1998, working with X-ray observations of elliptical galaxies from the Röntgen Satellite (ROSAT; Joel Bregman was her advisor). She compiled and analyzed the first large complete sample of such galaxies with ROSAT and her papers in this area made an impact in the field. Following her PhD, Beth Brown held a National Academy of Science & National Research Council Postdoctoral Research Fellowship at NASA's Goddard Space Flight Center. Subsequently, she became a civil servant at the National Space Science Data Center at GSFC, where she was involved in data archival activities as well as education and outreach, a continuing passion in her life. In 2006, Brown became an Astrophysics Fellow at GSFC, during which time she worked as a visiting Assistant Professor at Howard University, where she taught and worked with students and faculty to improve the teaching observatory. At the time of her death, she was eagerly looking forward to a new position at GSFC as the Assistant Director for Science Communications and Higher Education. Beth Brown was a joyous individual who loved to work with people, especially in educating them about our remarkable field. Her warmth and openness was a great aid in making accessible explanations of otherwise daunting astrophysical

  13. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

    DEFF Research Database (Denmark)

    Hiraike, Yuta; Waki, Hironori; Yu, Jing


    Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white fat followed by motif analysis of brown-fat-specific open chromatin regions...... results in brown adipocyte differentiation. Conversely, the brown fat of NFIA-knockout mice displays impaired expression of the brown-fat-specific genes and reciprocal elevation of muscle genes. Finally, expression of NFIA and the brown-fat-specific genes is positively correlated in human brown fat...

  14. The Luminosities of the Coldest Brown Dwarfs (United States)

    Tinney, C. G.; Faherty, Jacqueline K.; Kirkpatrick, J. Davy; Cushing, Mike; Morley, Caroline V.; Wright, Edward L.


    In recent years, brown dwarfs have been extended to a new Y-dwarf class with effective temperatures colder than 500 K and masses in the range of 5-30 Jupiter masses. They fill a crucial gap in observable atmospheric properties between the much colder gas-giant planets of our own solar system (at around 130 K) and both hotter T-type brown dwarfs and the hotter planets that can be imaged orbiting young nearby stars (both with effective temperatures in the range of 1500-1000 K). Distance measurements for these objects deliver absolute magnitudes that make critical tests of our understanding of very cool atmospheres. Here we report new distances for nine Y dwarfs and seven very late T dwarfs. These reveal that Y dwarfs do indeed represent a continuation of the T-dwarf sequence to both fainter luminosities and cooler temperatures. They also show that the coolest objects display a large range in absolute magnitude for a given photometric color. The latest atmospheric models show good agreement with the majority of these Y-dwarf absolute magnitudes. This is also the case for WISE0855-0714, the coldest and closest brown dwarf to the Sun, which shows evidence for water ice clouds. However, there are also some outstanding exceptions, which suggest either binarity or the presence of condensate clouds. The former is readily testable with current adaptive optics facilities. The latter would mean that the range of cloudiness in Y dwarfs is substantial with most hosting almost no clouds—while others have dense clouds, making them prime targets for future variability observations to study cloud dynamics. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

  15. The luminosities of the coldest brown dwarfs

    Energy Technology Data Exchange (ETDEWEB)

    Tinney, C. G. [School of Physics, UNSW Australia, NSW 2052 (Australia); Faherty, Jacqueline K. [Department of Terrestrial Magnetism, Carnegie Institution of Washington, Washington DC 20005 (United States); Kirkpatrick, J. Davy [Infrared Processing and Analysis Center, MS100-22, California Institute of Technology, Pasadena, CA 91125 (United States); Cushing, Mike [Department of Physics and Astronomy, The University of Toledo, OH 43606 (United States); Morley, Caroline V. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Wright, Edward L., E-mail: [Department of Physics and Astronomy, UCLA, Los Angeles, CA 90095-1547 (United States)


    In recent years, brown dwarfs have been extended to a new Y-dwarf class with effective temperatures colder than 500 K and masses in the range of 5-30 Jupiter masses. They fill a crucial gap in observable atmospheric properties between the much colder gas-giant planets of our own solar system (at around 130 K) and both hotter T-type brown dwarfs and the hotter planets that can be imaged orbiting young nearby stars (both with effective temperatures in the range of 1500-1000 K). Distance measurements for these objects deliver absolute magnitudes that make critical tests of our understanding of very cool atmospheres. Here we report new distances for nine Y dwarfs and seven very late T dwarfs. These reveal that Y dwarfs do indeed represent a continuation of the T-dwarf sequence to both fainter luminosities and cooler temperatures. They also show that the coolest objects display a large range in absolute magnitude for a given photometric color. The latest atmospheric models show good agreement with the majority of these Y-dwarf absolute magnitudes. This is also the case for WISE0855-0714, the coldest and closest brown dwarf to the Sun, which shows evidence for water ice clouds. However, there are also some outstanding exceptions, which suggest either binarity or the presence of condensate clouds. The former is readily testable with current adaptive optics facilities. The latter would mean that the range of cloudiness in Y dwarfs is substantial with most hosting almost no clouds—while others have dense clouds, making them prime targets for future variability observations to study cloud dynamics.

  16. Dan Brown : The Da Vinci Code (Sakrileg)


    Meier, Albert


    Wer in Paris die Kirche Saint-Sulpice besucht, wird dort in mehreren Sprachen vor einem Buch gewarnt: »Le risque de Da Vinci Code: semer le doute«. Die Lektüre von The Da Vinci Code soll also mit einer Gefahr verbunden sein: dass Zweifel gesät werden am katholischen Glauben und an der Autorität der römischen Kirche. Der amerikanische Bestseller-Autor Dan Brown hätte insofern tatsächlich das begangen, was sein 2003 erschienener Thriller über die Suche nach dem heiligen Gral zum deutschen Titel...

  17. Brown Dwarf Like Behaviors of Jupiter (United States)

    Ghosh, K.


    Jupiter is by far the most massive object in our solar system after the Sun having mass of about 10-3 M&odot, M&odot being the mass of the Sun. Its density is significantly lower than that of the inner planets; just 1.3 g cm-3 while the densities of Mercury, Venus, Earth and Mars are respectively 5.4, 5.3, 5.5 and 3.9 g cm-3. Jupiter radiates more energy into space than it receives from the Sun. It is proposed that the interior of Jupiter has excess energy stored since the time of its collapse. The heat is also generated by the Kelvin-Helmholtz mechanism, the slow gravitational compression of the configuration. This heat within Jupiter contributes to the unusual motion in the internal rotation in Jupiter. Motions in the interior of Jupiter contribute in a very special way to the development of the powerful and extensive magnetosphere of Jupiter. These observations indicate that the composition of Jupiter is basically different from that of the inner planets and these properties of Jupiter are significantly similar to the features of rotating brown dwarfs under the consideration of magnetic field which are thought to be objects having mass between stars and planets. The stellar bodies with mass less than the lower mass limit of the main sequence become completely degenerate as a consequence of gravitational contraction and consequently they cannot go through normal stellar evolution. Primarily they were named 'Black Dwarf.' The modern term for these objects is 'Brown Dwarf.' In their young age (<10^8 years) they contract rapidly and the gravitational binding energy released makes them quite luminous, but as they age they cool rapidly and make them harder to detect. Calculations show a significant similarity in this paper between the presently observed configuration of Jupiter with that of the model brown dwarf under the consideration of internal rotation and magnetic field with mass, composition and age same that of Jupiter which leads to to a conclusion that

  18. Analysis of Brown camera distortion model (United States)

    Nowakowski, Artur; Skarbek, Władysław


    Contemporary image acquisition devices introduce optical distortion into image. It results in pixel displacement and therefore needs to be compensated for many computer vision applications. The distortion is usually modeled by the Brown distortion model, which parameters can be included in camera calibration task. In this paper we describe original model, its dependencies and analyze orthogonality with regard to radius for its decentering distortion component. We also report experiments with camera calibration algorithm included in OpenCV library, especially a stability of distortion parameters estimation is evaluated.

  19. Cause and control of Radix Ophiopogonis browning during storage. (United States)

    Wang, Hui; Qi, Jin; Han, Dong-Qi; Xu, Tian; Liu, Ji-Hua; Qin, Min-Jian; Zhu, Dan-Ni; Bo-Yang, Yu


    In the storage of Radix Ophiopogonis, browning often happens to cause potential risk with regard to safety. Previously few reports investigate the browning of Radix Ophiopogonis. In this research, the causes and mechanisms of the browning of Radix Ophiopogonis were preliminarily elucidated. Content determination by high-performance liquid chromatography (HPLC) and spectrophotometry, enzyme activity determination by colorimetry, and morphological observation by electron microscopy were performed in the present study. Uniform design and three-dimensional response surfaces were applied to investigate the relationship between browning and storage factors. The cortex cell wall of browned Radix Ophiopogonis was ruptured. Compared with the normal Radix Ophiopogonis, cellulase and polyphenol oxidase enzymes were activated, the levels of 5-hydroxymethylfurfural (5-HMF), total sugars, and reducing sugars were increased, while the levels of polysaccharides and methylophiopogonanone A were decreased in browned Radix Ophiopogonis. The relationship between the storage factors and degree of browning (Y) could be described by following correlation equation: Y = - 0.625 4 + 0.020 84 × X3 + 0.001 514 × X1 × X2 - 0.000 964 4 × X2 × X3. Accompanied with browning under storage conditions, the chemical composition of Radix Ophiopogonis was altered. Following the activation of cellulase, the rupture of the cortex cell wall and the outflow of cell substances flowed out, which caused the Radix Ophiopogonis tissue to become soft and sticky. The main causes of the browning were the production of 5-HMF, the activation of polyphenol oxidase, Maillard reactions and enzymatic browning. Browning could be effectively prevented when the air relative humidity (HR), temperature, and moisture content were under 25% RH, 12 °C and 18%, respectively. Copyright © 2015 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  20. Chandra Captures Flare From Brown Dwarf (United States)


    The first flare ever seen from a brown dwarf, or failed star, was detected by NASA's Chandra X-ray Observatory. The bright X-ray flare has implications for understanding the explosive activity and origin of magnetic fields of extremely low mass stars. Chandra detected no X-rays at all from LP 944-20 for the first nine hours of a twelve hour observation, then the source flared dramatically before it faded away over the next two hours. "We were shocked," said Dr. Robert Rutledge of the California Institute of Technology in Pasadena, the lead author on the discovery paper to appear in the July 20 issue of Astrophysical Journal Letters. "We didn't expect to see flaring from such a lightweight object. This is really the 'mouse that roared.'" Chandra LP 944-20 X-ray Image Press Image and Caption The energy emitted in the brown dwarf flare was comparable to a small solar flare, and was a billion times greater than observed X-ray flares from Jupiter. The flaring energy is believed to come from a twisted magnetic field. "This is the strongest evidence yet that brown dwarfs and possibly young giant planets have magnetic fields, and that a large amount of energy can be released in a flare," said Dr. Eduardo Martin, also of Caltech and a member of the team. Professor Gibor Basri of the University of California, Berkeley, the principal investigator for this observation, speculated that the flare "could have its origin in the turbulent magnetized hot material beneath the surface of the brown dwarf. A sub-surface flare could heat the atmosphere, allowing currents to flow and give rise to the X-ray flare -- like a stroke of lightning." LP 944-20 is about 500 million years old and has a mass that is about 60 times that of Jupiter, or 6 percent that of the Sun. Its diameter is about one-tenth that of the Sun and it has a rotation period of less than five hours. Located in the constellation Fornax in the southern skies, LP 944-20 is one of the best studied brown dwarfs because it is

  1. Brown Dwarfs: Up Close and Physical (United States)

    Basri, G. B.


    I review what has now been nearly a decade of progress in the study of brown dwarfs as physical objects. The definition of brown dwarfs as distinct from stars or planets has some subtlety, and is an amalgam of considerations. I briefly discuss their internal structure, and the evolution of luminosity sources within them. Deuterium and lithium can be used as external probes of their internal state. I next discuss the effective temperature scale for the new L and T spectral classes. Formation of dust in the atmospheres of these objects is a crucial determinant of their spectral appearance, as is the conversion of typical molecules from oxides to hydrides. Not only is the chemical formation of dust important, but proper treatment of cloud formation and dust settling is clearly important (``meteorology'' becomes a consideration). This can strongly affect the colors of the objects, and the visibility of spectral features. Finally, I summarize results on other physical properties which can be studied using high spectral and angular resolution, including angular momentum, magnetic activity, surface gravity, and binarity.

  2. Dermatoses of Belchatow brown coal mine employees

    Energy Technology Data Exchange (ETDEWEB)

    Ruszczak, Z.; Bienias, L.; Proszczynska-Kuczynska, W.


    Evaluates the results of examinations carried out in the Belchatow brown coal surface mine on skin diseases. Influence of working conditions specific for brown coal mines on the development of some dermatoses is analyzed. From 1978 to 1979 443 miners were examined. Two groups of miners were examined separately: 1. 235 miners who contacted the firm physician due to skin problems and 2. 208 miners who underwent a periodic examination. In group 1 skin dermatoses were found in 86% of all cases, and in group 2 in 48%. Foot skin inflammation, particularly interdigital intertrigo, was the most common dermatosis. Oil acne (occupational disease of coal miners) was diagnosed in 15 cases, common acne in 23 cases, pytiriasis versicolor in 19 cases, erythrasma in 10, eczema and other contact dermatitis in 10 cases. Investigations show that 23% of the foot interdigital intertrigo is caused by mycotic infections. Dermatoses of the skin of miners' feet are caused mainly by rubber protective boots. (10 refs.) (In Polish)

  3. The role of lipids in nonenzymatic browning

    Directory of Open Access Journals (Sweden)

    Zamora, Rosario


    Full Text Available The role of lipids in nonenzymatic browning is studied by reviewing oxidized lipid/protein reactions in comparison with other reactions where the production of browning is known: the Maillard reaction, the ascorbic acid browning, and the quinone/amine reactions. The mechanisms proposed in these reactions for production of color and fluorescence, as well as the formation of melanoidins, lipofuscins, and low molecular weight colored products are discussed comparatively, concluding that the role of lipids in these reactions does not seem to be very different to the role of carbohydrates in the Maillard reaction or the phenols in the enzymatic browning. These carbonyl-amine reactions seem to be a group of gradual, partially reversible, universal, and inevitable side reactions in both food and biological systems. However, most of these results were obtained in model systems and additional studies should be carried out in systems closer to real foods or living beings, which should provide a more complete understanding of nonenzymatic browning, and, therefore, to afford a much more comprehensive knowledge of food and human biochemistry.En este trabajo se hace una revisión del papel de los lípidos en el pardeamiento no enzimático de alimentos mediante el estudio de las reacciones proteína/lípido oxidado en comparación con otras reacciones donde ocurre también este oscurecimiento: la reacción de Maillard, el pardeamiento producido por el ácido ascórbico, y las reacciones de las quinonas con los grupos amino. Los mecanismos propuestos para estas reacciones de producción de color y fluorescencia, así como la formación de melanoidinas, lipofuscinas y productos coloreados de bajo peso molecular son discutidos de forma comparada, concluyendo que el papel de los lípidos en estas reacciones no parece ser muy diferente del papel de los carbohidratos en el Maillard o de los fenoles en el pardeamiento enzimático. Estas reacciones carbonil

  4. File list: Unc.Adp.05.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Adp.05.AllAg.Brown_preadipocytes mm9 Unclassified Adipocyte Brown preadipocytes... ...

  5. File list: Unc.Adp.50.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Adp.50.AllAg.Brown_preadipocytes mm9 Unclassified Adipocyte Brown preadipocytes... ...

  6. File list: Unc.Adp.10.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Adp.10.AllAg.Brown_preadipocytes mm9 Unclassified Adipocyte Brown preadipocytes... ...

  7. File list: Unc.Adp.20.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.Adp.20.AllAg.Brown_preadipocytes mm9 Unclassified Adipocyte Brown preadipocytes... ...

  8. Genetic backgrounds determine brown remodeling of white fat in rodents. (United States)

    Ferrannini, Giulia; Namwanje, Maria; Fang, Bin; Damle, Manashree; Li, Dylan; Liu, Qiongming; Lazar, Mitchell A; Qiang, Li


    Genetic background largely contributes to the complexity of metabolic responses and dysfunctions. Induction of brown adipose features in white fat, known as brown remodeling, has been appreciated as a promising strategy to offset the positive energy balance in obesity and further to improve metabolism. Here we address the effects of genetic background on this process. We investigated browning remodeling in a depot-specific manner by comparing the response of C57BL/6J, 129/Sv and FVB/NJ mouse strains to cold. Surprisingly, 129/Sv and FVB/NJ mice showed distinct brown remodeling features despite their similar resistance to metabolic disorders in comparison to the obesity-prone C57BL/6J mice. FVB/NJ mice demonstrated a preference of brown remodeling in inguinal subcutaneous white adipose tissue (iWAT), whereas 129/Sv mice displayed robust brown remodeling in visceral epididymal fat (eWAT). We further compared gene expression in different depots by RNA-sequencing and identified Hoxc10 as a novel "brake" of brown remodeling in iWAT. Rodent genetic background determines the brown remodeling of different white fat depots. This study provides new insights into the role of genetic variation in fat remodeling in susceptibility to metabolic diseases.

  9. Parent–offspring recognition in the Brown-headed Parrot ...

    African Journals Online (AJOL)

    Parent–offspring recognition in the Brown-headed Parrot Poicephalus cryptoxanthus. ... Parent–offspring recognition in the Brown-headed Parrot Poicephalus cryptoxanthus. Stuart Taylor, Michael R Perrin. Abstract. Recognition by vocal characteristics between parents and their offspring is thought to be ubiquitous in ...

  10. Mir193b-365 is essential for brown fat differentiation. (United States)

    Sun, Lei; Xie, Huangming; Mori, Marcelo A; Alexander, Ryan; Yuan, Bingbing; Hattangadi, Shilpa M; Liu, Qingqing; Kahn, C Ronald; Lodish, Harvey F


    Mammals have two principal types of fat. White adipose tissue primarily serves to store extra energy as triglycerides, whereas brown adipose tissue is specialized to burn lipids for heat generation and energy expenditure as a defence against cold and obesity. Recent studies have demonstrated that brown adipocytes arise in vivo from a Myf5-positive, myoblastic progenitor by the action of Prdm16 (PR domain containing 16). Here, we identified a brown-fat-enriched miRNA cluster, MiR-193b-365, as a key regulator of brown fat development. Blocking miR-193b and/or miR-365 in primary brown preadipocytes markedly impaired brown adipocyte adipogenesis by enhancing Runx1t1 (runt-related transcription factor 1; translocated to, 1) expression, whereas myogenic markers were significantly induced. Forced expression of Mir193b and/or Mir365 in C2C12 myoblasts blocked the entire programme of myogenesis, and, in adipogenic conditions, miR-193b induced myoblasts to differentiate into brown adipocytes. Mir193b-365 was upregulated by Prdm16 partially through Pparα. Our results demonstrate that Mir193b-365 serves as an essential regulator for brown fat differentiation, in part by repressing myogenesis.

  11. Phytase activity in brown rice during steeping and sprouting

    NARCIS (Netherlands)

    Ou, K.; Cheng, Y.; Xing, Y.; Lin, L.; Nout, M.J.R.; Liang, J.


    Phytase in brown rice will be activated and accumulated during seed germination. Changes of phytase activity in brown rice during two stages of germination (steeping and sprouting) affected by process conditions were studied. It was shown that steeping led to significant decrease of phytase activity

  12. Ouabain-sensitive component of brown fat thermogenesis. (United States)

    Horwitz, B. A.


    The study discussed was undertaken to quantify the amount of energy utilized by the ouabain-sensitive Na(+)-K(+) membrane pump during the norepinephrine-induced thermogenesis of brown adipose tissue. The data obtained indicate that the observed inhibition of the catecholamine-induced increase in brown fat thermogenesis by ouabain does not reflect an inhibition of cyclic AMP synthesis.

  13. Witnessing "Brown": Pursuit of an Equity Agenda in American Education (United States)

    Smith, Anne; Kozleski, Elizabeth B.


    The 50th anniversary of the "Brown v. Board of Education" decision provides a critical opportunity to reflect on "Brown's" importance, impact, and the lessons it provides on achieving racial desegregation and its relationship to the progressive inclusion of students with disabilities into public schools across the United…

  14. The Troublesome Legacy of "Brown v. Board of Education" (United States)

    López, Gerardo R.; Burciaga, Rebeca


    Purpose: This article reflects on the 60th anniversary of the "Brown v. Board of Education" Supreme Court decision while discussing the significant lessons learned from this and subsequent court decisions. Argument: In this article, we posit that a fundamentally different conversation surrounding the legacy of Brown is needed if we are…

  15. Lyme disease masquerading as brown recluse spider bite. (United States)

    Osterhoudt, Kevin C; Zaoutis, Theoklis; Zorc, Joseph J


    We report a case of Lyme disease with clinical features resembling those described from brown recluse spider bites. The most striking manifestation was a necrotic skin wound. Brown recluse spider bites may be overdiagnosed in some geographic regions. Tick bite and infection with Borrelia burgdorferi should be considered in the differential diagnosis of necrotic arachnidism in regions endemic for Lyme disease.

  16. Enzymatic browning and its control in fresh-cut produce (United States)

    Enzymatic browning of damaged tissues of fruits and vegetables during postharvest handling and processing degrades the sensory properties and nutritional value and discourages the consumer purchase of fresh-cut products. Consequently, enzymatic browning results in significant economic losses for the...

  17. Brown Adipogenic Reprogramming Induced by a Small Molecule

    Directory of Open Access Journals (Sweden)

    Baoming Nie


    Full Text Available Brown adipose tissue (BAT has attracted considerable research interest because of its therapeutic potential to treat obesity and associated metabolic diseases. Augmentation of brown fat mass and/or its function may represent an attractive strategy to enhance energy expenditure. Using high-throughput phenotypic screening to induce brown adipocyte reprogramming in committed myoblasts, we identified a retinoid X receptor (RXR agonist, bexarotene (Bex, that efficiently converted myoblasts into brown adipocyte-like cells. Bex-treated mice exhibited enlarged BAT mass, enhanced BAT function, and a modest browning effect in subcutaneous white adipose tissue (WAT. Expression analysis showed that Bex initiated several “browning” pathways at an early stage during brown adipocyte reprogramming. Our findings suggest RXRs as new master regulators that control brown and beige fat development and activation, unlike the common adipogenic regulator PPARγ. Moreover, we demonstrated that selective RXR activation may potentially offer a therapeutic approach to manipulate brown/beige fat function in vivo.

  18. Differential gene expression in white and brown preadipocytes

    NARCIS (Netherlands)

    Boeuf, S.; Klaus, S.; Klingenspor, M.; Schneider, T.; Franssen-Hal, van N.L.W.; Keijer, J.


    White (WAT) and brown (BAT) adipose tissue are tissues of energy storage and energy dissipation, respectively. Experimental evidence suggests that brown and white preadipocytes are differentially determined, but so far not much is known about the genetic control of this determination process. The

  19. Physicochemical properties of germinated brown rice ( Oryza sativa L.)

    African Journals Online (AJOL)

    Physicochemical properties of white rice (WR), brown rice (BR) and germinated brown rice (GBR) starches from a mixed variety of MR219 and MR220, commonly consumed Malaysian varieties, were compared in this study. The granular size of the starch particles, measured using scanning electron microscope (SEM), ...

  20. Investigation of metal ions sorption of brown peat moss powder (United States)

    Kelus, Nadezhda; Blokhina, Elena; Novikov, Dmitry; Novikova, Yaroslavna; Chuchalin, Vladimir


    For regularities research of sorptive extraction of heavy metal ions by cellulose and its derivates from aquatic solution of electrolytes it is necessary to find possible mechanism of sorption process and to choice a model describing this process. The present article investigates the regularities of aliovalent metals sorption on brown peat moss powder. The results show that sorption isotherm of Al3+ ions is described by Freundlich isotherm and sorption isotherms of Na+ i Ni2+ are described by Langmuir isotherm. To identify the mechanisms of brown peat moss powder sorption the IR-spectra of the initial brown peat moss powder samples and brown peat moss powder samples after Ni (II) sorption were studied. Metal ion binding mechanisms by brown peat moss powder points to ion exchange, physical adsorption, and complex formation with hydroxyl and carboxyl groups.

  1. Platform construction of molecular breeding for utilization of brown macroalgae. (United States)

    Takagi, Toshiyuki; Kuroda, Kouichi; Ueda, Mitsuyoshi


    Brown macroalgae are characterized by a large size and high productivity without requiring arable land, fresh water, and fertilizer. Furthermore, since brown macroalgae contain little or no lignin, simple biorefinery processing can efficiently produce sugars from this material. Therefore, brown macroalgae have attracted attention as an alternative feedstock for bioethanol production. However, the utilization of biotechnologies previously developed for terrestrial biomass processing results in difficulties in the bioconversion of brown macroalgae. Recently, several studies have developed biotechnologies for using major carbohydrates of brown macroalgae, such as laminarin, mannitol, and alginate. This review focuses on these fermentation biotechnologies using natural or engineered microorganisms. Copyright © 2017 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  2. MiR-193b-365, a brown fat enriched microRNA cluster, is essential for brown fat differentiation (United States)

    Sun, Lei; Xie, Huangming; Mori, Marcelo A; Alexander, Ryan; Yuan, Bingbing; Hattangadi, Shilpa M.; Liu, Qingqing; Kahn, C. Ronald; Lodish, Harvey F.


    Mammals have two principal types of fat. White adipose tissue (WAT) primarily serves to store extra energy as triglycerides, while brown adipose tissue (BAT) is specialized to burn lipids for heat generation and energy expenditure as a defense against cold and obesity 1, 2. Recent studies demonstrate that brown adipocytes arise in vivo from a Myf5-positive, myoblastic progenitor by the action of Prdm16 (PR domain containing 16). Here, we identified a brown fat-enriched miRNA cluster, miR-193b-365, as a key regulator of brown fat development. Blocking miR-193b and/or miR-365 in primary brown preadipocytes dramatically impaired brown adipocyte adipogenesis by enhancing Runx1t1 (runt-related transcription factor 1; translocated to, 1) expression whereas myogenic markers were significantly induced. Forced expression of miR-193b and/or miR-365 in C2C12 myoblasts blocked the entire program of myogenesis, and, in adipogenic condition, miR-193b induced myoblasts to differentiate into brown adipocytes. MiR-193b-365 was upregulated by Prdm16 partially through Pparα. Our results demonstrate that miR-193b-365 serves as an essential regulator for brown fat differentiation, in part by repressing myogenesis. PMID:21743466

  3. Tony L. Brown and Joshua A. Brown d/b/a Riverview Cattle - Clean Water Act Public Notice (United States)

    The EPA is providing notice of a proposed Administrative Penalty Assessment against Tony L. Brown and Joshua A. Brown d/b/a Riverview Cattle, located in Emmet County, Iowa, for alleged violations at their concentrated animal feeding operation located at 18

  4. Browning and graying: novel transcriptional regulators of brown and beige fat tissues and aging

    Directory of Open Access Journals (Sweden)

    Elisabetta eMueller


    Full Text Available Obesity represents a major risk factor for the development of a number of metabolic disorders, including cardiovascular disease and type 2 diabetes. Since the discovery that brown and beige fat cells exist in adult humans and contribute to energy expenditure, increasing interest has been devoted to the understanding of the molecular switches turning on calorie utilization. It has been reported that the ability of thermogenic tissues to burn energy declines during aging, possibly contributing to the development of metabolic dysfunction late in life. This review will focus on the recently identified transcriptional modulators of brown and beige cells and will discuss the potential impact of some of these thermogenic factors on age-associated metabolic disorders.

  5. NMR studies of polysaccharides from brown seaweeds

    Energy Technology Data Exchange (ETDEWEB)

    Noseda, M.D.; Tisher, C.A.; Gorin, P.A.J.; Duarte, M.E.R. [Parana Univ., Curitiba, PR (Brazil). Dept. de Bioquimica; Cerezo, A.S. [Buenos Aires Univ. Nacional (Argentina). Dept. de Quimica Organica


    Alginic acid is the major intercellular polysaccharide serving as matrix in the brown algae and is comprised of an unbranched chain of (1->4)-linked {beta}-D-mannuronic acid (M) and {alpha}-L-guluronic acid (G), arranged in a blockwise fashion. The composition of the monomer residues and the block structure varies depending on the source of the polymer. The selective binding of cations to alginate accounts for its ability to form gels, which is dependent on the number and lenght of the G-blocks. They are widely used industrially for their ability to retain water, and for their gelling, viscosifying and stabilizing properties (Smidsrod and draget, 1996). In this study, alginate composition and block structure in Sargassum stenophyllum has been determined by chemical methods and NMR spectroscopic analysis. (author) 4 refs., 3 figs.

  6. From a Brown to a Green Economy

    DEFF Research Database (Denmark)

    Svendsen, Gert Tinggaard


    One main theme in the Rio+20 Conference was how to facilitate the growth of green industries. How can politicians more specifically promote renewable green industries such as wind turbines or solar energy? How can we get prices right in the market? Prices can be adjusted by the use of economic...... instruments such as taxes and subsidies. In this way, renewable energy sources and green industries become more competitive, thus enhancing the transition from brown to green economy. Not only can these economic incentives accelerate the so-called switch point in time from fossil fuel–based energy sources...... to those not based on fossil fuel, they also encourage innovation. An illustrative example of this logic in practice is the case of Danish wind energy production....

  7. Brown v. Plata: prison overcrowding in California. (United States)

    Newman, William J; Scott, Charles L


    California's prisons are currently designed to house approximately 85,000 inmates. At the time of the U.S. Supreme Court's 2011 decision in Brown v. Plata, the California prison system housed nearly twice that many (approximately 156,000 inmates). The Supreme Court held that California's prison system violated inmates' Eighth Amendment rights. The Court upheld a three-judge panel's order to decrease the population of California's prisons by an estimated 46,000 inmates. They determined that overcrowding was the primary cause of the inmates' inadequate medical and mental health care. As a result, the California Department of Corrections and Rehabilitation (CDCR) has been working to redistribute inmates and parolees safely and decrease the overall population to the mandated levels. These large-scale adjustments to California's penal system create potential opportunities to study the long-term effects on affected inmates.

  8. Applied paleobotany and brown coal petrology: plant texture as a basis for brown coal structure

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, W.


    A selection of 28 microscopic oil immersion photographs is provided showing major groups of plant tissue found in Tertiary brown coal deposits. These groups are bark tissue (peridermo-textit), leaf tissue (phyllo-textit), palm tree tissue and root tissue (rhizo-textit). Explanations on type of plants, cell structures of plants, and degree of coalification are also provided. Conclusions on the paleoenvironment are made. 25 references.

  9. Arsenic, organic foods, and brown rice syrup. (United States)

    Jackson, Brian P; Taylor, Vivien F; Karagas, Margaret R; Punshon, Tracy; Cottingham, Kathryn L


    Rice can be a major source of inorganic arsenic (Asi) for many sub-populations. Rice products are also used as ingredients in prepared foods, some of which may not be obviously rice based. Organic brown rice syrup (OBRS) is used as a sweetener in organic food products as an alternative to high-fructose corn syrup. We hypothesized that OBRS introduces As into these products. We determined the concentration and speciation of As in commercially available brown rice syrups and in products containing OBRS, including toddler formula, cereal/energy bars, and high-energy foods used by endurance athletes. We used inductively coupled plasma mass spectrometry (ICP-MS) and ion chromatography coupled to ICP-MS to determine total As (Astotal) concentrations and As speciation in products purchased via the Internet or in stores in the Hanover, New Hampshire, area. We found that OBRS can contain high concentrations of Asi and dimethyl-arsenate (DMA). An "organic" toddler milk formula containing OBRS as the primary ingredient had Astotal concentrations up to six times the U.S. Environmental Protection Agency safe drinking water limit. Cereal bars and high-energy foods containing OBRS also had higher As concentrations than equivalent products that did not contain OBRS. Asi was the main As species in most food products tested in this study. There are currently no U.S. regulations applicable to As in food, but our findings suggest that the OBRS products we evaluated may introduce significant concentrations of Asi into an individual's diet. Thus, we conclude that there is an urgent need for regulatory limits on As in food.

  10. Avipoxvirus infections in brown kiwi (Apteryx mantelli). (United States)

    Ha, H J; Alley, Mr; Howe, L; Castro, I; Gartrell, B


    Nodular lesions were found on the skin of two immature brown kiwi (Apteryx mantelli) less than 6 months of age living freely on Ponui Island off the North Island of New Zealand. The lesions were observed during routine external examination undertaken as a part of the management of other research projects, one in 2006 and the other in 2011. Apart from the skin lesions, both birds showed no signs of illness and the lesions resolved spontaneously over a 2-month period. The first case showed several 3-mm diameter firm, brown nodules located on the skin below the hock of both legs. The second case had a single multinodular mass that measured 7×20 mm, on the base of the bill. A portion of the mass and scab samples were collected for diagnosis. Histological examination of the nodules revealed severe ballooning degeneration of keratinocytes and epithelial hyperplasia. Round eosinophilic structures resembling avipoxvirus (APV) intracytoplasmic inclusion bodies (Bollinger bodies) were observed in the layers of keratinocytes. In deeper layers of the epidermis, there was evidence of secondary bacterial growth and inflammation. DNA was extracted from tissue samples and subjected to PCR analysis. Avipoxvirus 4b core protein gene was detected in both samples by PCR. Bootstrap analysis of APV 4b core protein gene revealed that APV isolates from two kiwi comprised two different subclades. One isolate displayed 100% sequence homology to subclade B1, and the other presented 100% sequence homology to subclade A3. This study confirmed that kiwi are susceptible to APV infection and that at least two different strains of APV are present in the population examined. Since there is no information on the origin, virulence, or prevalence of APV in kiwi, a seroprevalence study would be useful to elucidate the degree of exposure and immune response to the disease. This would allow a more informed approach to risk management of the disease in wild and captive populations.

  11. Drivers of hibernation in the brown bear. (United States)

    Evans, A L; Singh, N J; Friebe, A; Arnemo, J M; Laske, T G; Fröbert, O; Swenson, J E; Blanc, S


    Hibernation has been a key area of research for several decades, essentially in small mammals in the laboratory, yet we know very little about what triggers or ends it in the wild. Do climatic factors, an internal biological clock, or physiological processes dominate? Using state-of-the-art tracking and monitoring technology on fourteen free-ranging brown bears over three winters, we recorded movement, heart rate (HR), heart rate variability (HRV), body temperature (Tb), physical activity, ambient temperature (TA), and snow depth to identify the drivers of the start and end of hibernation. We used behavioral change point analyses to estimate the start and end of hibernation and convergent cross mapping to identify the causal interactions between the ecological and physiological variables over time. To our knowledge, we have built the first chronology of both ecological and physiological events from before the start to the end of hibernation in the field. Activity, HR, and Tb started to drop slowly several weeks before den entry. Bears entered the den when snow arrived and when ambient temperature reached 0 °C. HRV, taken as a proxy of sympathetic nervous system activity, dropped dramatically once the bear entered the den. This indirectly suggests that denning is tightly coupled to metabolic suppression. During arousal, the unexpected early rise in Tb (two months before den exit) was driven by TA, but was independent of HRV. The difference between Tb and TA decreased gradually suggesting that bears were not thermoconforming. HRV increased only three weeks before exit, indicating that late activation of the sympathetic nervous system likely finalized restoration of euthermic metabolism. Interestingly, it was not until TA reached the presumed lower critical temperature, likely indicating that the bears were seeking thermoneutrality, that they exited the den. We conclude that brown bear hibernation was initiated primarily by environmental cues, but terminated by

  12. Brown adipose tissue in cetacean blubber.

    Directory of Open Access Journals (Sweden)

    Osamu Hashimoto

    Full Text Available Brown adipose tissue (BAT plays an important role in thermoregulation in species living in cold environments, given heat can be generated from its chemical energy reserves. Here we investigate the existence of BAT in blubber in four species of delphinoid cetacean, the Pacific white-sided and bottlenose dolphins, Lagenorhynchus obliquidens and Tursiops truncates, and Dall's and harbour porpoises, Phocoenoides dalli and Phocoena phocoena. Histology revealed adipocytes with small unilocular fat droplets and a large eosinophilic cytoplasm intermingled with connective tissue in the innermost layers of blubber. Chemistry revealed a brown adipocyte-specific mitochondrial protein, uncoupling protein 1 (UCP1, within these same adipocytes, but not those distributed elsewhere throughout the blubber. Western blot analysis of extracts from the inner blubber layer confirmed that the immunohistochemical positive reaction was specific to UCP1 and that this adipose tissue was BAT. To better understand the distribution of BAT throughout the entire cetacean body, cadavers were subjected to computed tomography (CT scanning. Resulting imagery, coupled with histological corroboration of fine tissue structure, revealed adipocytes intermingled with connective tissue in the lowest layer of blubber were distributed within a thin, highly dense layer that extended the length of the body, with the exception of the rostrum, fin and fluke regions. As such, we describe BAT effectively enveloping the cetacean body. Our results suggest that delphinoid blubber could serve a role additional to those frequently attributed to it: simple insulation blanket, energy storage, hydrodynamic streamlining or contributor to positive buoyancy. We believe delphinoid BAT might also function like an electric blanket, enabling animals to frequent waters cooler than blubber as an insulator alone might otherwise allow an animal to withstand, or allow animals to maintain body temperature in cool

  13. Effects of brown coal treatment with hydrogen peroxide on brown coal wax yield

    Energy Technology Data Exchange (ETDEWEB)

    Bazarova, O.V.; Shevchenko, A.G.; Ruban, I.V.; Ksenofontov, V.G.; Turovskii, N.A. (Institut Fiziko-Organicheskoi Khimii i Uglekhimii AN UkrSSR (USSR))


    Studies preliminary treatment of brown coal with 30% hydrogen peroxide. Experiments employed 0.1-0.2 mm fractions of brown coal and were carried out at ambient temperature for 30 min with a coal:oxidizer ratio of 1:6. Sample demineralization met the requirements of ISO 602. Spectral resonance methods were employed to find that the oxidation processes of brown coal and of anthracite are similar; two spectra are presented. Coal extraction employed petroleum ether. Pre-treatment increased the wax yield from 4.3% to 10.5% in terms of coal organic mass. Wax elemental compositions are presented. Six IR spectra are shown and discussed: of initial coal wax, of pre-treated coal wax, of initial coal, of pre-treated coal, of initial coal residue (after its extraction) and of pre-treated coal residue. The 1,020 cm{sup -1} band was observed to suggest the formation of phenol structures during oxidation. The 1,610 cm{sup -1} band of aromatic structures with carboxylic groups increased its intensity. The wax hydrogen content doubled and H/O increased by 1/3-1/4. 12 refs.

  14. Study on enzymatic browning in suspension cultures of licorice cells

    Directory of Open Access Journals (Sweden)

    Yali Li


    Full Text Available Enzymatic browning is one of the main obstacles encountered in the establishment of suspension systems of licorice cells. Browning of cells may result in decreased viability, poor growth and even death. The present study investigated the mechanism of browning reactions and the effective controlling methods. The results showed that the cell viability and membrane permeabilization obviously changed when the cells were transferred to liquid medium. The transformation caused rapid increase in the levels of polyphenol oxidase activity and in the production of polyphenols. Osmotic and hydrodynamic stresses arising from liquid culture were regarded as the major causes of enzymatic browning. Ascorbic acid and L-cysteine were found to be the most significant anti-browning agents that could decrease the degree of browning with 55.8% and 52.2%, respectively, at the end of the suspension culture's lag phase. When cultured with a cycle of 21 days, the maximum biomass of the cells cultured with ascorbic acid and L-cysteine increased with 31.1% and 26.5%, respectively, when compared to the control. These findings may be essential for the development of licorice cell cultures devoted to browning prevention and cell viability maintaining.

  15. Browning control of fresh-cut lettuce by phytoncide treatment. (United States)

    Kim, Do-Hee; Kim, Han-Bit; Chung, Hun-Sik; Moon, Kwang-Deog


    Phytoncide essential oil derived from pine leaves was applied for the control of enzymatic browning of fresh-cut lettuce. Changes in the browning characteristics of cut lettuce treated with phytoncide in an water or ethanol solution (1%, v/v) at 10°C were investigated for 12days at 4°C. Other samples dipped in distilled water or 95% ethanol were used as the controls. The samples treated with phytoncide in an ethanol solution showed significantly higher L* values and lower a* values, ΔE values, browning index, phenolic compounds, and enzyme activities (PPO, POD, PAL) related to browning. The samples dipped in distilled water showed the opposite tendency. On the basis of changes in the browning characteristics, anti-browning effects of each treatment, phytoncide in an ethanol solution was the most effective treatment applied. These results suggest that phytoncide treatment could be used as an effective method for controlling enzymatic browning in fresh-cut lettuce. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. The Gq signalling pathway inhibits brown and beige adipose tissue (United States)

    Klepac, Katarina; Kilić, Ana; Gnad, Thorsten; Brown, Loren M.; Herrmann, Beate; Wilderman, Andrea; Balkow, Aileen; Glöde, Anja; Simon, Katharina; Lidell, Martin E.; Betz, Matthias J.; Enerbäck, Sven; Wess, Jürgen; Freichel, Marc; Blüher, Matthias; König, Gabi; Kostenis, Evi; Insel, Paul A.; Pfeifer, Alexander


    Brown adipose tissue (BAT) dissipates nutritional energy as heat via the uncoupling protein-1 (UCP1) and BAT activity correlates with leanness in human adults. Here we profile G protein-coupled receptors (GPCRs) in brown adipocytes to identify druggable regulators of BAT. Twenty-one per cent of the GPCRs link to the Gq family, and inhibition of Gq signalling enhances differentiation of human and murine brown adipocytes. In contrast, activation of Gq signalling abrogates brown adipogenesis. We further identify the endothelin/Ednra pathway as an autocrine activator of Gq signalling in brown adipocytes. Expression of a constitutively active Gq protein in mice reduces UCP1 expression in BAT, whole-body energy expenditure and the number of brown-like/beige cells in white adipose tissue (WAT). Furthermore, expression of Gq in human WAT inversely correlates with UCP1 expression. Thus, our data indicate that Gq signalling regulates brown/beige adipocytes and inhibition of Gq signalling may be a novel therapeutic approach to combat obesity. PMID:26955961

  17. Browning boreal forests of western North America (United States)

    Verbyla, David


    The GIMMS NDVI dataset has been widely used to document a 'browning trend' in North American boreal forests (Goetz et al 2005, Bunn et al 2007, Beck and Goetz 2011). However, there has been speculation (Alcaraz-Segura et al 2010) that this trend may be an artifact due to processing algorithms rather than an actual decline in vegetation activity. This conclusion was based primarily on the fact that GIMMS NDVI did not capture NDVI recovery within most burned areas in boreal Canada, while another dataset consistently showed post-fire increasing NDVI. I believe that the results of Alcaraz-Segura et al (2010) were due simply to different pixel sizes of the two datasets (64 km2 versus 1 km2 pixels). Similar results have been obtained from tundra areas greening in Alaska, with the results simply due to these pixel size differences (Stow et al 2007). Furthermore, recent studies have documented boreal browning trends based on NDVI from other sensors. Beck and Goetz (2011) have shown the boreal browning trend derived from a different sensor (MODIS) to be very similar to the boreal browning trend derived from the GIMMS NDVI dataset for the circumpolar boreal region. Parent and Verbyla (2010) found similar declining NDVI patterns based on NDVI from Landsat sensors and GIMMS NDVI in boreal Alaska. Zhang et al (2008) found a similar 'browning trend' in boreal North America based on a production efficiency model using an integrated AVHRR and MODIS dataset. The declining NDVI trend in areas of boreal North America is consistent with tree-ring studies (D'Arrigo et al 2004, McGuire et al 2010, Beck et al 2011). The decline in tree growth may be due to temperature-induced drought stress (Barber et al 2000) caused by higher evaporative demands in a warming climate (Lloyd and Fastie 2002). In a circumpolar boreal study, Lloyd and Bunn (2007) found that a negative relationship between temperature and tree-ring growth occurred more frequently in warmer parts of species' ranges

  18. Discovery of Nearest Known Brown Dwarf (United States)


    Bright Southern Star Epsilon Indi Has Cool, Substellar Companion [1] Summary A team of European astronomers [2] has discovered a Brown Dwarf object (a 'failed' star) less than 12 light-years from the Sun. It is the nearest yet known. Now designated Epsilon Indi B, it is a companion to a well-known bright star in the southern sky, Epsilon Indi (now "Epsilon Indi A"), previously thought to be single. The binary system is one of the twenty nearest stellar systems to the Sun. The brown dwarf was discovered from the comparatively rapid motion across the sky which it shares with its brighter companion : the pair move a full lunar diameter in less than 400 years. It was first identified using digitised archival photographic plates from the SuperCOSMOS Sky Surveys (SSS) and confirmed using data from the Two Micron All Sky Survey (2MASS). Follow-up observations with the near-infrared sensitive SOFI instrument on the ESO 3.5-m New Technology Telescope (NTT) at the La Silla Observatory confirmed its nature and has allowed measurements of its physical properties. Epsilon Indi B has a mass just 45 times that of Jupiter, the largest planet in the Solar System, and a surface temperature of only 1000 °C. It belongs to the so-called 'T dwarf' category of objects which straddle the domain between stars and giant planets. Epsilon Indi B is the nearest and brightest T dwarf known. Future studies of the new object promise to provide astronomers with important new clues as to the formation and evolution of these exotic celestial bodies, at the same time yielding interesting insights into the border zone between planets and stars. TINY MOVING NEEDLES IN GIANT HAYSTACKS ESO PR Photo 03a/03 ESO PR Photo 03a/03 [Preview - JPEG: 400 x 605 pix - 92k [Normal - JPEG: 1200 x 1815 pix - 1.0M] Caption: PR Photo 03a/03 shows Epsilon Indi A (the bright star at far right) and its newly discovered brown dwarf companion Epsilon Indi B (circled). The upper image comes from one of the SuperCOSMOS Sky

  19. Pre-germinated Parboiled Brown Rice Drying Using Fluidization Technique


    Nattapol Poomsa-ad; Lamul Wiset


    Pre-germinated parboiled brown rice or Khao hang (in Thai) is paddy which undergoing the processes of soaking, steaming, drying and dehusking to obtain the edible form for consumption. The objectives of this research were to study the kinetic of pre-germinated parboiled brown rice drying using fluidization technique and to study the properties of pre-germinated parboiled brown rice after drying. The dryings were performed at the different temperatures of 110, 120 and 130 oC at the bed depth o...

  20. The browning kinetics of the non-enzymatic browning reaction in L-ascorbic acid/basic amino acid systems

    Directory of Open Access Journals (Sweden)

    Ai-Nong YU

    Full Text Available Abstract Under the conditions of weak basis and the reaction temperature range of 110-150 °C, lysine, arginine and histidine were reacted with L-ascorbic acid at equal amount for 30-150 min, respectively and the formation of browning products was monitored with UV–vis spectrometry. The kinetic characteristics of their non-enzymatic browning reaction were investigated. The study results indicated that the non-enzymatic browning reaction of these three amino acids with L-ascorbic acid to form browning products was zero-order reaction. The apparent activation energies for the formation of browning products from L-ascorbic acid/lysine, L-ascorbic acid/arginine and L-ascorbic acid/histidine systems were 54.94, 50.08 and 35.31kJ/mol. The activation energy data indicated the degree of effects of reaction temperature on non-enzymatic browning reaction. Within the temperature range of 110-150 °C, the reaction rate of L-ascorbic acid/lysine system was the fastest one, followed by that of the L-ascorbic acid/arginine system. The reaction rate of L-ascorbic acid/histidine system was the slowest one. Based on the observed kinetic data, the formation mechanisms of browning products were proposed.

  1. The browning kinetics of the non-enzymatic browning reaction in L-ascorbic acid/basic amino acid systems


    YU,Ai-Nong; Li, Ya; Yang, Yan; Yu, Ke


    Abstract Under the conditions of weak basis and the reaction temperature range of 110-150 °C, lysine, arginine and histidine were reacted with L-ascorbic acid at equal amount for 30-150 min, respectively and the formation of browning products was monitored with UV–vis spectrometry. The kinetic characteristics of their non-enzymatic browning reaction were investigated. The study results indicated that the non-enzymatic browning reaction of these three amino acids with L-ascorbic acid to ...

  2. Genetic backgrounds determine brown remodeling of white fat in rodents

    Directory of Open Access Journals (Sweden)

    Giulia Ferrannini


    Conclusion: Rodent genetic background determines the brown remodeling of different white fat depots. This study provides new insights into the role of genetic variation in fat remodeling in susceptibility to metabolic diseases.

  3. Rüütel, Halonen ja Brown? / Eve Heinla

    Index Scriptorium Estoniae

    Heinla, Eve, 1966-


    James Browni kontserdil 27. juulil Tallinna laulukaare all loodetakse kaasa tõmmata ka poliitikud. Ameerika soulmuusik James Brown esitas president Arnold Rüütlile kutse laulda koos temaga duetti. Lisa: Rüütlil siiani Annaniga laulmata

  4. Stock status update of Browns Bank North Scallops (Placopecten magellanicus)

    National Research Council Canada - National Science Library

    Keith, David; Broome, Jeremy; Reeves, Alan; Drew, Tricia Pearo; Themelis, Daphne; Stone, Heath; Bennett, Lottie; Docherty, Verna


    .... The purpose of this report is to update the status of Browns Bank North Scallop with data from the 2016 Scallop survey and fishery to provide science advice for the management of the 2017 fishery...

  5. Data for Brown et al MEA Developmental Neurotoxicity Screening Manuscript (United States)

    U.S. Environmental Protection Agency — These data are the individual parameter and well-level data that were support the conclusions in Brown et al. Note: the parameters CVtime and CVnetwork were not...

  6. John Browne (1642-1702): anatomist and plagiarist. (United States)

    Loukas, Marios; Akiyama, Matthew; Shoja, Mohammadali M; Yalçin, Bulent; Tubbs, R Shane; Cohen-Gadol, Aaron A


    In contrast to many other physicians of his age, John Browne (1642-1702), an English anatomist and surgeon, managed to strike a balance in his career that spanned relative obscurity, prestige, and notoriety. Among his more prestigious credits, Browne was Surgeon in Ordinary to King Charles II and William III. He also had numerous publications to his name, some of which are credited as great innovations. His career, however, was tempered by his most important book, which has been critiqued by his contemporaries as well as modern historians as plagiarism. Although Browne undeniably copied the works of others and published them under his name, he was not alone in this practice. Various forms of intellectual thievery were common in Browne's day, and there were many perpetrators. The life of this overlooked figure in the history of anatomy and the stigma attached to him will be examined.

  7. Regulatory circuits controlling white versus brown adipocyte differentiation

    DEFF Research Database (Denmark)

    Hansen, Jacob B; Kristiansen, Karsten


    1 (uncoupling protein 1), can dissipate energy through adaptive thermogenesis. In rodents, ample evidence supports BAT as an organ counteracting obesity, whereas less is known about the presence and significance of BAT in humans. Despite the different functions of white and brown adipocytes......, knowledge of factors differentially influencing the formation of white and brown fat cells is sparse. Here we summarize recent progress in the molecular understanding of white versus brown adipocyte differentiation, including novel insights into transcriptional and signal transduction pathways. Since...... expression of UCP1 is the hallmark of BAT and a key factor determining energy expenditure, we also review conditions associated with enhanced energy expenditure and UCP1 expression in WAT that may provide information on processes involved in brown adipocyte differentiation....

  8. Brown Trout Distribution, Pacific Northwest (updated March, 2006) (United States)

    Pacific States Marine Fisheries Commission — This dataset is a record of fish distribution and activity for BROWN TROUT contained in the StreamNet database. This feature class was created based on linear event...

  9. Narrative report Browns Park National Wildlife Refuge: Calendar year 1965 (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Browns Park National Wildlife Refuge outlines Refuge accomplishments during the 1965 calendar year. The report begins with a brief...

  10. Integrated Pest Management Plan Browns Park National Wildlife Refuge (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of the Integrated Pest Management Plan is to provide a comprehensive, environmentally sensitive approach to managing pests on the Browns Park National...

  11. Narrative report : Browns Park National Wildlife Refuge 1968 (United States)

    US Fish and Wildlife Service, Department of the Interior — This annual narrative report for Browns Park National Wildlife Refuge outlines Refuge accomplishments during the 1968 calendar year. The report begins by summarizing...

  12. Ectocarpus: a model organism for the brown algae. (United States)

    Coelho, Susana M; Scornet, Delphine; Rousvoal, Sylvie; Peters, Nick T; Dartevelle, Laurence; Peters, Akira F; Cock, J Mark


    The brown algae are an interesting group of organisms from several points of view. They are the dominant organisms in many coastal ecosystems, where they often form large, underwater forests. They also have an unusual evolutionary history, being members of the stramenopiles, which are very distantly related to well-studied animal and green plant models. As a consequence of this history, brown algae have evolved many novel features, for example in terms of their cell biology and metabolic pathways. They are also one of only a small number of eukaryotic groups to have independently evolved complex multicellularity. Despite these interesting features, the brown algae have remained a relatively poorly studied group. This situation has started to change over the last few years, however, with the emergence of the filamentous brown alga Ectocarpus as a model system that is amenable to the genomic and genetic approaches that have proved to be so powerful in more classical model organisms such as Drosophila and Arabidopsis.

  13. News and Reports Notes on the Observations of Brown Water ...

    African Journals Online (AJOL)

    News and Reports Notes on the Observations of Brown Water Discolouration off the Light House Beach, Lagos, Nigeria. D I Nwankwo, I C Onyema, C O Labiran, A O Otuorumo, E I Onadipe, M O Ebulu, N Emubaiye ...

  14. Postcolonial Anxieties and the Browning of New Zealand Rugby

    National Research Council Canada - National Science Library

    Andrew D Grainger; Mark Falcous; Joshua I Newman


    This article examines postcolonial race politics and the re-centering of embodied whiteness and mediated white bodies as constituted through "white flight" and the so-called browning of rugby in New Zealand...

  15. NOAA Ship Ronald Brown Underway Meteorological Data, Near Real Time (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship Ronald Brown Underway Meteorological Data (Near Real Time, updated daily) are from the Shipboard Automated Meteorological and Oceanographic System (SAMOS)...

  16. NOAA Ship Ronald Brown Underway Meteorological Data, Quality Controlled (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Ship Ronald Brown Underway Meteorological Data (delayed ~10 days for quality control) are from the Shipboard Automated Meteorological and Oceanographic System...

  17. characterisation of bacterial brown spot pathogen from dry bean ...

    African Journals Online (AJOL)

    Prof. Adipala Ekwamu

    2011 $ ... BROWN SPOT PATHOGEN FROM DRY BEAN. PRODUCTION AREAS OF SOUTH AFRICA. H.T.H. MUEDI, D. FOURIE and N.W. MCLAREN1. Agricultural Research Council - Grain Crops Institute, 114 Chris Hani Street, Potchefstroom,.

  18. Personality variation in little brown bats. (United States)

    Menzies, Allyson K; Timonin, Mary E; McGuire, Liam P; Willis, Craig K R


    Animal personality or temperament refers to individual differences in behaviour that are repeatable over time and across contexts. Personality has been linked to life-history traits, energetic traits and fitness, with implications for the evolution of behaviour. Personality has been quantified for a range of taxa (e.g., fish, songbirds, small mammals) but, so far, there has been little work on personality in bats, despite their diversity and potential as a model taxon for comparative studies. We used a novel environment test to quantify personality in little brown bats (Myotis lucifugus) and assess the short-term repeatability of a range of behaviours. We tested the hypothesis that development influences values of personality traits and predicted that trait values associated with activity would increase between newly volant, pre-weaning young-of-the-year (YOY) and more mature, self-sufficient YOY. We identified personality dimensions that were consistent with past studies of other taxa and found that these traits were repeatable over a 24-hour period. Consistent with our prediction, older YOY captured at a fall swarming site prior to hibernation had higher activity scores than younger YOY bats captured at a maternity colony, suggesting that personality traits vary as development progresses in YOY bats. Thus, we found evidence of short-term consistency of personality within individuals but with the potential for temporal flexibility of traits, depending on age.

  19. JVLA Observations of Young Brown Dwarfs

    Energy Technology Data Exchange (ETDEWEB)

    Rodríguez, Luis F.; Zapata, Luis A.; Palau, Aina, E-mail:, E-mail:, E-mail: [Instituto de Radioastronomía y Astrofísica, UNAM, Apdo. Postal 3-72 (Xangari), 58089 Morelia, Michoacán, México (Mexico)


    We present sensitive 3.0 cm JVLA radio continuum observations of six regions of low-mass star formation that include twelve young brown dwarfs (BDs) and four young BD candidates. We detect a total of 49 compact radio sources in the fields observed, of which 24 have no reported counterparts and are considered new detections. Twelve of the radio sources show variability in timescales of weeks to months, suggesting gyrosynchrotron emission produced in active magnetospheres. Only one of the target BDs, FU Tau A, was detected. However, we detected radio emission associated with two of the BD candidates, WL 20S and CHLT 2. The radio flux densities of the sources associated with these BD candidates are more than an order of magnitude larger than expected for a BD and suggest a revision of their classification. In contrast, FU Tau A falls on the well-known correlation between radio luminosity and bolometric luminosity, suggesting that the emission comes from a thermal jet and that this BD seems to be forming as a scaled-down version of low-mass stars.

  20. Brown Grease to Biodiesel Demonstration Project Report

    Energy Technology Data Exchange (ETDEWEB)

    San Francisco Public Utilities Commission; URS Corporation; Biofuels, Blackgold; Carollo Engineers


    program by other municipal agencies (as applicable). In order to accomplish the goals of the project, the following steps were performed: 1. Operation of a demonstration facility designed to receive 10,000 to 12,000 gallons of raw Trap Waste each day from private Trap Waste hauling companies. The demonstration facility was designed and built by Pacific Biodiesel Technologies (PBTech). The demonstration facility would also recover 300 gallons of Brown Grease per day from the raw Trap Waste. The recovered Brown Grease was expected to contain no more than 2% Moisture, Insolubles, and Unsaponifiables (MIU) combined. 2. Co-digestion of the side streams (generated during the recovery of 300 gallons of Brown Grease from the raw Trap Waste) with wastewater sludge in the WWTP's anaerobic digesters. The effects of the side streams on anaerobic digestion were quantified by comparison with baseline data. 3. Production of 240 gallons per day of ASTM D6751-S15 grade Biodiesel fuel via a Biodiesel conversion demonstration facility, with the use of recovered Brown Grease as a feedstock. The demonstration facility was designed and built by Blackgold Biofuels (BGB). Side streams from this process were also co-digested with wastewater sludge. Bench-scale anaerobic digestion testing was conducted on side streams from both demonstration facilities to determine potential toxicity and/or changes in biogas production in the WWTP anaerobic digester. While there is a lot of theoretical data available on the lab-scale production of Biodiesel from grease Trap Waste, this full-scale demonstration project was one of the first of its kind in the United States. The project's environmental impacts were expected to include: Reduction of greenhouse gas emissions by prevention of the release of methane at landfills. Although the combustion product of Biodiesel and Methane gas produced in the Anaerobic digester, Carbon Dioxide, is also a greenhouse gas; it is 20 times weaker for the same amount

  1. The NIRSPEC Brown Dwarf Spectroscopic Survey (United States)

    McGovern, M. R.; McLean, I. S.; Prato, L.; Burgasser, A. J.; Kirkpatrick, J. D.


    The major goal of the NIRSPEC Brown Dwarf Spectroscopic Survey (BDSS - McLean et al. 2000, ApJ, 533, L45) is to obtain a complete sample of low resolution (R ~ 2000) spectra spanning the M, L, and T dwarf sub-classes in order to extend spectral classification schemes to near-infrared wavebands and to investigate the spectral signatures of temperature, gravity, and composition by comparison to theoretical models. Additional goals include the acquisition of higher resolution spectra (R ~ 25,000) of a sub-sample of the survey for detailed comparison with models and to search for radial velocity variations. The initial phase of the survey is complete with the acquisition of low resolution J-band spectra for two objects per sub-class spanning the range M6 to T8, with one object every other sub-class, in the same range, observed from 0.9-2.35 microns to produce a complete, flux-calibrated spectrum overlapping with previously obtained Keck LRIS data from 0.5-1.0 microns. Several of the brighter sources have also been observed at high resolution at J-band. To date, over 70 objects have been studied including 17 M dwarfs, 36 L dwarfs and 18 T dwarfs. Results from the initial phase of the survey are presented along with some preliminary results from our next directed phase study into the investigation of gravity signatures in these low-mass objects based upon infrared spectral features.

  2. Rapid pyrolysis of Serbian soft brown coals

    Energy Technology Data Exchange (ETDEWEB)

    Goran G. Jankes; Olga Cvetkovic; Nebojsa M. Milovanovic; Marko Ercegovaci Ercegovac; Miroljub Adzic; Mirjana Stamenic [University of Belgrade, Belgrade (Serbia). Faculty of Mechanical Engineering


    Soft brown coals of the open coal fields of Kolubara and Kostolac are the main domestic energy sources of Serbia. This paper presents the results of investigations on rapid devolatilization of these two coals which have covered kinetics of devolatilization (based on total volatile yield), forms of sulphur and petrographic analysis of coal and char. Experiments of devolatilization were performed in inert gas (N{sub 2}) at atmospheric pressure and in batch-type hot-wire screen reactor. The mass-loss values of both coals at selected final reaction temperatures (300-900{sup o}C) and retention times (3-28 s) were obtained. Anthony and Howard's kinetic model was applied over two temperature ranges (300-500 and 700-900{sup o}C). The types of sulphur as monosulphide, sulphate, pyritic, and organic sulphur were determined for chars and original coals. Strong transformation of pyrite was evident even at low temperatures (300{sup o}C). Devolatilization of all types of sulphur has started over 600 and at 900{sup o}C the content of sulphur in char remained only 66% of total sulphur in original coal. Microscopic investigations were carried out on samples prepared for reflected light measurements. The petrographic analysis included: the ratio of unchanged and changed coal, maceral types, the share of cenospheres, isotropic mixed carbonized grains, mixed grains, small fragments, clay, and pyrite. The change of the structure of devolatilized coal was also observed. 20 refs., 10 figs., 6 tabs.

  3. Activation of brown adipose tissue in hypothyroidism. (United States)

    Lapa, Constantin; Maya, Yoshifumi; Wagner, Martin; Arias-Loza, Paula; Werner, Rudolf A; Herrmann, Ken; Higuchi, Takahiro


    Brown adipose tissue (BAT) attracts growing interest as a potential therapeutic target for obesity and diabetes. Hyperthyroidism is well-known to increase BAT activity, but the role of hypothyroidism is controversial. We aimed to investigate the association between different thyroid hormone (TH) states and BAT activity. FDG-PET studies were retrospectively evaluated in thyroid cancer patients after total thyroidectomy both at euthyroidism during TH replacement or at hypothyroidism after TH cessation. Serum TH levels were compared between patients with active BAT and control patients with non-active BAT matched for age, gender, and body mass index. Additionally, animal experiments with controls (n = 5) and hypothyroid rats (n = 5) were performed. Out of 124 patients, 6 patients with active BAT were identified. These patients showed significantly higher thyroid-stimulating hormone (TSH) levels than matched controls (P hypothyroid animals showed BAT activation at room temperature (24 °C), whereas controls did not (P hypothyroidism, which might be the result of a feedback mechanism to maintain body temperature in a state of reduced basal thermogenesis. Future research needs to explore the underlying mechanistic and biological implications.

  4. Brown Fat Expresses Adiponectin in Humans

    Directory of Open Access Journals (Sweden)

    Gianluca Iacobellis


    Full Text Available The presence of brown adipose tissue (BAT in humans is unclear. Pheochromocytomas (PHEO are rare tumors of neuroectodermal origin which occur in 0.1-0.2% of patients with hypertension. We sought to evaluate the presence and activity of BAT surrounding adrenal PHEO in a well-studied sample of 11 patients who were diagnosed with PHEO and then underwent adrenalectomy. Areas of white fat (WAT and BAT surrounding PHEO were obtained by Laser Capture Microdissection for analysis of uncoupling protein (UCP-1 and adiponectin mRNA expression. Adiponectin and UCP-1 mRNA levels were significantly higher in BAT than in WAT (0.62 versus 0.15 and 362.4 versus 22.1, resp., for both. Adiponectin mRNA levels significantly correlated with urinary metanephrines (, , vanilly mandelic acid (VMA (, , and serum adiponectin levels (, . Serum adiponectin levels significantly decreased ( μg/mL versus  μg/mL, after adrenalectomy in PHEO subjects. This study provides the following findings: (1 BAT surrounding PHEO expresses adiponectin and UCP-1 mRNA, (2 expression of adiponectin mRNA is significantly higher in BAT than in WAT surrounding PHEO, and (3 catecholamines and serum adiponectin levels significantly correlate with BAT UCP-1 and adiponectin mRNA.

  5. Rapid pyrolysis of Serbian soft brown coals

    Directory of Open Access Journals (Sweden)

    Jankes Goran


    Full Text Available Soft brown coals of the open coal fields of Kolubara and Kostolac are the main domestic energy sources of Serbia. This paper presents the results of investigations on rapid devolatilization of these two coals which have covered kinetics of devolatilization (based on total volatile yield, forms of sulphur and petrographic analysis of coal and char. Experiments of devolatilization were performed in inert gas (N2 at atmospheric pressure and in batch-type hot-wire screen reactor. The mass-loss values of both coals at selected final reaction temperatures (300-900°C and retention times (3-28 s were obtained. Anthony and Howard's kinetic model was applied over two temperature ranges (300-500 and 700-900°C. The types of sulphur as monosulphide, sulphate, pyritic, and organic sulphur were determined for chars and original coals. Strong transformation of pyrite was evident even at low temperatures (300°C. Devolatilization of all types of sulphur has started over 600 and at 900°C the content of sulphur in char remained only 66% of total sulphur in original coal. Microscopic investigations were carried out on samples prepared for reflected light measurements. The petrographic analysis included: the ratio of unchanged and changed coal, maceral types, the share of cenosferes, isotropic mixed carbonized grains, mixed grains, small fragments, clay, and pyrite. The change of the structure of devolatilized coal was also observed.

  6. Dietary Fat Overload Reprograms Brown Fat Mitochondria

    Directory of Open Access Journals (Sweden)



    Full Text Available Chronic nutrient overload accelerates the onset of several aging-related diseases reducing life expectancy. Although the mechanisms by which overnutrition affects metabolic processes in many tissues are known, its role on BAT physiology is still unclear. Herein, we investigated the mitochondrial responses in BAT of female mice exposed to high fat diet (HFD at different steps of life. Although adult mice showed an unchanged mitochondrial amount, both respiration and OxPHOS subunits were strongly affected. Differently, offspring pups exposed to HFD during pregnancy and lactation displayed reduced mitochondrial mass but high oxidative efficiency that, however, resulted in increased bioenergetics state of BAT rather than augmented uncoupling respiration. Interestingly, the metabolic responses triggered by HFD were accompanied by changes in mitochondrial dynamics characterized by decreased content of the fragmentation marker Drp1 both in mothers and offspring pups. HFD-induced inactivation of the FoxO1 transcription factor seemed to be the up-stream modulator of Drp1 levels in brown fat cells. Furthermore, HFD offspring pups weaned with normal diet only partially reverted the mitochondrial dysfunctions caused by HFD. Finally these mice failed in activating the thermogenic program upon cold exposure. Collectively our findings suggest that maternal dietary fat overload irreversibly commits BAT unresponsiveness to physiological stimuli such as cool temperature and this dysfunction in the early stage of life might negatively modulates health and lifespan.

  7. Method for baghouse brown plume pollution control

    Energy Technology Data Exchange (ETDEWEB)

    Hooper, R.G.


    This patent describes an SO{sub x}/NO{sub x} air pollution control process employing a baghouse to simultaneously control particulate emissions. It comprises: introducing a sodium-based reagent into a stream of flue gas containing SO{sub x} and NO{sub x}; introducing urea as an additive into the flue gases; maintaining the reagent and the additive in contact with the flue gas to react the reagent with some of the SO{sub x} and NO{sub x} thereby reducing the concentration of the SO{sub x} and NO{sub x} in the flue gas; the additive, as compared to use of the reagent without the additive, increasing the percent SO{sub x} removal and the percent NO{sub x} removal by the reagent while suppressing conversion of NO to NO{sub 2} by the reagent to below about the visible brown plume threshold; and collecting the reacted reagent and additive in a baghouse.

  8. Table grapes suffer water loss, stem browning during cooling delays


    Crisosto, Carlos H.; Smilanick, Joe L.; Dokoozlian, Nick


    The water loss in table grapes that occurs during postharvest handling can lead to stem browning, berry shatter, and wilting and shriveling of the fruit. Critical grape cluster water-loss threshold values for stem browning were determined for Perlette, Thompson Seedless, Flame Seedless, Fantasy Seedless and Redglobe table grape cultivars. Fantasy Seedless and Redglobe withstood higher levels of stem water loss than Perlette, Flame Seedless and Thompson Seedless before expressing moderate to s...

  9. Apple phenolics and their contribution to enzymatic browning reactions

    Directory of Open Access Journals (Sweden)

    Wiesław Oleszek


    Full Text Available Chlorogenic acid, epicatechin, procyanidin B2 and C1 were isolated from apple skin. These compounds as well as quercetine and phloretine glycosides isolated from apples were studied individually and as mixtures for their participation in the enzymatic browning reactions. The importance of quercetine glycosides and the synergistic effect of phloridzin and phloretine xyloglucoside with chlorogenic acid and flavans in the browning reaction are reported.

  10. Orexin receptor-1 mediates brown fat developmental differentiation


    Sellayah, Dyan; Sikder, Devanjan


    Orexin A (OX) is a small excitatory neuropeptide hormone that stimulates feeding, wakefulness and energy expenditure via a pair of G-coupled protein receptors, namely orexin receptor-1 (OXR1) and orexin receptor-2 (OXR2). OX-deficient mice are sensitive to obesity despite being hypophagic. The obesogenic effect of OX-deletion is due to brown adipose tissue (BAT) dysfunction, a defect that originates during fetal growth. Brown preadipocytes in OX-null mice display undifferentiated histological...

  11. Clouds and Hazes in Exoplanets and Brown Dwarfs


    Morley, Caroline Victoria


    The formation of clouds significantly alters the spectra of cool substellar atmospheres from terrestrial planets to brown dwarfs. In cool planets like Earth and Jupiter, volatile species like water and ammonia condense to form ice clouds. In hot planets and brown dwarfs, iron and silicates instead condense, forming dusty clouds. Irradiated methane-rich planets may have substantial hydrocarbon hazes. During my dissertation, I have studied the impact of clouds and hazes in a variety of substell...

  12. Absence of the fourth cranial nerve in congenital Brown syndrome. (United States)

    Kaeser, Pierre-François; Kress, Bodo; Rohde, Stefan; Kolling, Gerold


    To elucidate the aetiology of congenital Brown syndrome. Four consecutive patients diagnosed with unilateral congenital Brown syndrome had a comprehensive standardized ocular motility examination. Any compensatory head posture was measured. Brain magnetic resonance imaging (MRI) with regard for the IV cranial nerve (CN) was performed in all patients. Orbital MRI was performed in 2/4 patients, with images acquired in eight directions of gaze and superior oblique (SO) muscle areas compared. CN IV could not be identified bilaterally in two patients, but was absent only on the side of the Brown syndrome in the two other patients. On the normal side, orbital MRI revealed a smaller SO muscle area in upgaze than in downgaze, demonstrating normal actions of this muscle. On the side of the Brown syndrome, the SO area remained the same in upgaze and in downgaze and approximately symmetric to the area of SO in downgaze on the normal side. These cases add further anatomical support to the theory of paradoxical innervation in congenital Brown syndrome. CN IV was absent in two patients on the side of the Brown syndrome, but without muscle hypoplasia. SO muscle size did not vary in up- and downgaze, which we interpreted as a sign of constant innervation through branches of CN III. © 2012 The Authors. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation.

  13. Eggshell color in brown-egg laying hens - a review. (United States)

    Samiullah, S; Roberts, J R; Chousalkar, K


    The major pigment in eggshells of brown-egg laying hens is protoporphyrin IX, but traces of biliverdin and its zinc chelates are also present. The pigment appears to be synthesized in the shell gland. The protoporphyrin IX synthetic pathway is well defined, but precisely where and how it is synthesized in the shell gland of the brown-egg laying hen is still ambiguous. The pigment is deposited onto all shell layers including the shell membranes, but most of it is concentrated in the outermost layer of the calcareous shell and in the cuticle. Recently, the genes that are involved in pigment synthesis have been identified, but the genetic control of synthesis and deposition of brown pigment in the commercial laying hen is not fully understood. The brown coloration of the shell is an important shell quality parameter and has a positive influence on consumer preference. The extent of pigment deposition is influenced by the housing system, hen age, hen strain, diet, stressors, and certain diseases such as infectious bronchitis. In this article, the physiological and biochemical characteristics of the brown pigment in commercial brown-egg layers are reviewed in relation to its various functions in the poultry industry. © 2015 Poultry Science Association Inc.

  14. Platelet function in brown bear (Ursus arctos compared to man

    Directory of Open Access Journals (Sweden)

    Särndahl Eva


    Full Text Available Abstract Background Information on hemostasis and platelet function in brown bear (Ursus arctos is of importance for understanding the physiological, protective changes during hibernation. Objective The study objective was to document platelet activity values in brown bears shortly after leaving the den and compare them to platelet function in healthy humans. Methods Blood was drawn from immobilized wild brown bears 7-10 days after leaving the den in mid April. Blood samples from healthy human adults before and after clopidogrel and acetylsalicylic acid administration served as control. We analyzed blood samples by standard blood testing and platelet aggregation was quantified after stimulation with various agonists using multiple electrode aggregometry within 3 hours of sampling. Results Blood samples were collected from 6 bears (3 females between 1 and 16 years old and from 10 healthy humans. Results of adenosine diphosphate, aspirin, and thrombin receptor activating peptide tests in bears were all half or less of those in humans. Platelet and white blood cell counts did not differ between species but brown bears had more and smaller red blood cells compared with humans. Conclusion Using three different tests, we conclude that platelet function is lower in brown bears compared to humans. Our findings represent the first descriptive study on platelet function in brown bears and may contribute to explain how bears can endure denning without obvious thrombus building. However, the possibility that our findings reflect test-dependent and not true biological variations in platelet reactivity needs further studies.

  15. Brown Swiss in vergelijking met Braunvieh en enkele kruisingen (literatuuroverzicht) = Comparison of Brown Swiss with Braunvieh and some crossbreds

    NARCIS (Netherlands)

    Rooy, de J.


    De samengevatte literatuur betreft twee onderwerpen: vergelijkingen in de Verenigde Staten tussen de melkveerassen Brown Swiss en Braunvieh wat betreft melkgift en vruchtbaarheid en kruisingsproeven tussen deze rassen in Oostenrijk, Duitsland, Zwitserland en Denemarken

  16. An HST/STIS spectroscopic investigation: is Kelu-1 AB a brown dwarf - brown dwarf binary? (United States)

    Stumpf, Micaela


    We propose to obtain resolved HST/STIS spectroscopy for the benchmark binary brown dwarf Kelu-1 AB. Dynamical masses are being obtained by monitoring the orbital motion using ground-based telescopes with adaptive optics. The main goal of this program is to study the Li I resonance line at 670.8 nm and investigate if only one or even both components bear lithium. This observation will be compared to model predictions of lithium depletion as a function of age and mass, and including our model independent ground-based mass estimations, hence will provide an observational test to the theory of substellar objects. Spin-offs will be the measurement of the strength of H-alpha emission, an indicator of chromospheric activity in cool atmospheres, and comparing the shape of the optical continuum with model spectra with different dust opacities. Thus our program will be an important step towards the understanding of brown dwarf atmospheres and to establish precise models for their formation and evolution.

  17. Photochemical processing of aqueous atmospheric brown carbon

    Directory of Open Access Journals (Sweden)

    R. Zhao


    Full Text Available Atmospheric brown carbon (BrC is a collective term for light absorbing organic compounds in the atmosphere. While the identification of BrC and its formation mechanisms is currently a central effort in the community, little is known about the atmospheric removal processes of aerosol BrC. As a result, we report on a series of laboratory studies of photochemical processing of BrC in the aqueous phase, by direct photolysis and OH oxidation. Solutions of ammonium sulfate mixed with glyoxal (GLYAS or methylglyoxal (MGAS are used as surrogates for a class of secondary BrC mediated by imine intermediates. Three nitrophenol species, namely 4-nitrophenol, 5-nitroguaiacol and 4-nitrocatechol, were investigated as a class of water-soluble BrC originating from biomass burning. Photochemical processing induced significant changes in the absorptive properties of BrC. The imine-mediated BrC solutions exhibited rapid photo-bleaching with both direct photolysis and OH oxidation, with atmospheric half-lives of minutes to a few hours. The nitrophenol species exhibited photo-enhancement in the visible range during direct photolysis and the onset of OH oxidation, but rapid photo-bleaching was induced by further OH exposure on an atmospheric timescale of an hour or less. To illustrate the atmospheric relevance of this work, we also performed direct photolysis experiments on water-soluble organic carbon extracted from biofuel combustion samples and observed rapid changes in the optical properties of these samples as well. Overall, these experiments indicate that atmospheric models need to incorporate representations of atmospheric processing of BrC species to accurately model their radiative impacts.

  18. Brown-Vialetto-Van Laere syndrome

    Directory of Open Access Journals (Sweden)

    Sathasivam Sivakumar


    Full Text Available Abstract The Brown-Vialetto-Van Laere syndrome (BVVL is a rare neurological disorder characterized by progressive pontobulbar palsy associated with sensorineural deafness. Fifty-eight cases have been reported in just over 100 years. The female to male ratio is approximately 3:1. The age of onset of the initial symptom varies from infancy to the third decade. The syndrome most frequently presents with sensorineural deafness, which is usually progressive and severe. Lower cranial nerve involvement and lower and upper motor neuron limb signs are common neurological features. Other features include respiratory compromise (the most frequent non-neurological finding, limb weakness, slurring of speech, facial weakness, and neck and shoulder weakness. Optic atrophy, retinitis pigmentosa, macular hyperpigmentation, autonomic dysfunction, epilepsy may occur. The etiopathogenesis of the condition remains elusive. Approximately 50% of cases are familial, of which autosomal recessive is suggested. The remaining cases are sporadic. The diagnosis is usually based on the clinical presentation. Investigations (neurophysiological studies, magnetic resonance imaging of the brain, muscle biopsy, cerebrospinal fluid examination are done to exclude other causes or to confirm the clinical findings. The differential diagnoses include the Fazio-Londe syndrome, amyotrophic lateral sclerosis, Nathalie syndrome, Boltshauser syndrome and Madras motor neuron disease. Treatment with steroids or intravenous immunoglobulin may result in temporary stabilization of the syndrome. However, the mainstays of management are supportive and symptomatic treatment, in particular assisted ventilation and maintenance of nutrition via gastrostomy. The clinical course of BVVL is variable and includes gradual deterioration (almost half of cases, gradual deterioration with stable periods in between (a third of cases and deterioration with abrupt periods of worsening (just under a fifth of cases

  19. Central control of brown adipose tissue thermogenesis

    Directory of Open Access Journals (Sweden)

    Shaun F. Morrison


    Full Text Available Thermogenesis, the production of heat energy, is an essential component of the homeostatic repertoire to maintain body temperature during the challenge of low environmental temperature and plays a key role in elevating body temperature during the febrile response to infection. Mitochondrial oxidation in brown adipose tissue (BAT is a significant source of neurally-regulated metabolic heat production in many species from mouse to man. BAT thermogenesis is regulated by neural networks in the central nervous system which responds to feedforward afferent signals from cutaneous and core body thermoreceptors and to feedback signals from brain thermosensitive neurons to activate BAT sympathetic nerve activity. This review summarizes the research leading to a model of the feedforward reflex pathway through which environmental cold stimulates BAT thermogenesis and includes the influence on this thermoregulatory network of the pyrogenic mediator, prostaglandin E2, to increase body temperature during fever. The cold thermal afferent circuit from cutaneous thermal receptors, through second-order thermosensory neurons in the dorsal horn of the spinal cord ascends to activate neurons in the lateral parabrachial nucleus which drive GABAergic interneurons in the preoptic area to inhibit warm-sensitive, inhibitory output neurons of the preoptic area. The resulting disinhibition of BAT thermogenesis-promoting neurons in the dorsomedial hypothalamus activates BAT sympathetic premotor neurons in the rostral ventromedial medulla, including the rostral raphe pallidus, which provide excitatory, and possibly disinhibitory, inputs to spinal sympathetic circuits to drive BAT thermogenesis. Other recently recognized central sites influencing BAT thermogenesis and energy expenditure are also described.

  20. Introgressive hybridization: brown bears as vectors for polar bear alleles. (United States)

    Hailer, Frank


    The dynamics and consequences of introgression can inform about numerous evolutionary processes. Biologists have therefore long been interested in hybridization. One challenge, however, lies in the identification of nonadmixed genotypes that can serve as a baseline for accurate quantification of admixture. In this issue of Molecular Ecology, Cahill et al. (2015) analyse a genomic data set of 28 polar bears, eight brown bears and one American black bear. Polar bear alleles are found to be introgressed into brown bears not only near a previously identified admixture zone on the Alaskan Admiralty, Baranof and Chichagof (ABC) Islands, but also far into the North American mainland. Elegantly contrasting admixture levels at autosomal and X chromosomal markers, Cahill and colleagues infer that male-biased dispersal has spread these introgressed alleles away from the Late Pleistocene contact zone. Compared to a previous study on the ABC Island population in which an Alaskan brown bear served as a putatively admixture-free reference, Cahill et al. (2015) utilize a newly sequenced Swedish brown bear as admixture baseline. This approach reveals that brown bears have been impacted by introgression from polar bears to a larger extent (up to 8.8% of their genome), than previously known, including the bear that had previously served as admixture baseline. No evidence for introgression of brown bear into polar bear is found, which the authors argue could be a consequence of selection. Besides adding new exciting pieces to the puzzle of polar/brown bear evolutionary history, the study by Cahill and colleagues highlights that wildlife genomics is moving from analysing single genomes towards a landscape genomics approach. © 2015 John Wiley & Sons Ltd.

  1. Reports of envenomation by brown recluse spiders exceed verified specimens of Loxosceles spiders in South Carolina. (United States)

    Frithsen, Ivar L; Vetter, Richard S; Stocks, Ian C


    To determine whether the number of brown recluse spider bites diagnosed by South Carolina physicians coincides with evidence of brown recluse spiders found in the state. Brown recluse spider bite diagnosis data were extracted from 1990 and 2004 surveys of South Carolina physicians. This was compared with the known historical evidence of brown recluse spiders collected in South Carolina and derived from various sources, including state agencies, arachnologists, and museum specimens. South Carolina physicians diagnosed 478 brown recluse spider bites in 1990 and 738 in 2004. Dating to 1953, 44 brown recluse spider specimens have been verified from 6 locations in South Carolina. The number of brown recluse bites reportedly diagnosed in South Carolina greatly outnumbers the verified brown recluse specimens that have been collected in the state. The pattern of bite diagnoses outnumbering verified brown recluse specimens has been reported in other areas outside of this spider's known endemic range.

  2. Arctic Browning: vegetation damage and implications for carbon balance. (United States)

    Treharne, Rachael; Bjerke, Jarle; Emberson, Lisa; Tømmervik, Hans; Phoenix, Gareth


    'Arctic browning' is the loss of biomass and canopy in Arctic ecosystems. This process is often driven by climatic and biological extreme events - notably extreme winter warm periods, winter frost-drought and severe outbreaks of defoliating insects. Evidence suggests that browning is becoming increasingly frequent and severe at the pan-arctic scale, a view supported by observations from more intensely observed regions, with major and unprecedented vegetation damage reported at landscape (>1000km2) and regional (Nordic Arctic Region) scales in recent years. Critically, the damage caused by these extreme events is in direct opposition to 'Arctic greening', the well-established increase in productivity and shrub abundance observed at high latitudes in response to long-term warming. This opposition creates uncertainty as to future anticipated vegetation change in the Arctic, with implications for Arctic carbon balance. As high latitude ecosystems store around twice as much carbon as the atmosphere, and vegetation impacts are key to determining rates of loss or gain of ecosystem carbon stocks, Arctic browning has the potential to influence the role of these ecosystems in global climate. There is therefore a clear need for a quantitative understanding of the impacts of browning events on key ecosystem carbon fluxes. To address this, field sites were chosen in central and northern Norway and in Svalbard, in areas known to have been affected by either climatic extremes or insect outbreak and subsequent browning in the past four years. Sites were chosen along a latitudinal gradient to capture both conditions already causing vegetation browning throughout the Norwegian Arctic, and conditions currently common at lower latitudes which are likely to become more damaging further North as climate change progresses. At each site the response of Net Ecosystem CO2 Exchange to light was measured using a LiCor LI6400 Portable Photosynthesis system and a custom vegetation chamber with

  3. Effects of phenolic compounds on the browning of cooked barley. (United States)

    Kohyama, Noriko; Fujita, Masaya; Ono, Hiroshi; Ohnishi-Kameyama, Mayumi; Matsunaka, Hitoshi; Takayama, Toshiyuki; Murata, Masatsune


    Barley grain products undergo browning when cooked. To evaluate effects of phenolic compounds on browning, various amounts of (+)-catechin, proanthocyanidins, or related phenolic compounds were added to aqueous barley extracts or barley pastes, which were heated at 90 degrees C for 1 or 2 h, respectively. In barley extract, (+)-catechin, procyanidin B3 (PCB3), prodelphinidin B3 (PDB3), and a trimer of gallocatechin-gallocatechin-catechin (PDT1) dose-dependently elevated absorbance at 420 nm after heating. PDB3 caused browning faster than PCB3 and (+)-catechin. In barley paste, PDB3 and PDT1 decreased the L* value and increased the a* and b* values of the paste dose-dependently after heating and PCB3 and (+)-catechin did so to a lesser extent. Caffeic acid promoted the browning in both of the extract and paste, while protocatechuic acid, eriodictyol, and (+)-taxifolin promoted it in the extract and myricetin and quercetin promoted it in the paste. Compounds promoting browning have catechol or pyrogallol structures in common.

  4. Relationship in between Chemical Oxidation and Browning of Flavanols (United States)

    Dong, X.; Zhang, Y. L.; Wang, F.; Pang, M. X.; Qi, J. H.


    Catechin, epicatechin and chlorogenic acid are widely distributed in the plant kingdom. At present, influencing factors of phenol chemical oxidation is little research. In order to study non-enzymatic browning factors, this research utilized catechin, epicatechin and chlorogenic acid to establish simulation systems. The browning degree and products of flavanols were investigated by transmittance and high-performance liquid chromatography (HPLC). The main results and conclusions were follows. The brown generation is increased after phenols of chemical oxidation at 50°C and at pH 3.7 phosphate buffered saline, the sequence of influencing factor of browning is pH > kind of phenol > temperature. Oxidation of compounds of catechin and epicatechin results in formation of their Methylene quinone or o -Quinones. In addition, oxidation products of catechin, epicatechin and chlorogenic acid were mixture of different molecular sizes. The research has showed that brown generation correlated well with chemical oxidation of phenols and chemical oxidation reaction generated larger molecular weight polymers.

  5. Examining Cloud, Metallicity, and Gravity signatures in Brown Dwarfs (United States)

    Gonzales, Eileen; Faherty, Jacqueline K.; Gagné, Jonathan; Artigau, Étienne; BDNYC


    The nearby solar neighborhood is littered with low mass, low temperature objects called brown dwarfs. This population of ultracool objects do not have enough mass to sustain stable hydrogen burning so they never enter the main sequence and simply cool through time. Brown dwarfs span effective temperatures in the range 250 to 3000K. They also have age dependent observable properties. Young brown dwarfs appear to have redder near infrared colors than field age sources, while old objects tend to have bluer colors. Over the past several years, the research group entitled “Brown Dwarfs in New York City” (BDNYC) has been collecting optical, near and mid-infrared spectra, as well as photometry for sources that have well defined distances. In this poster, I will compare the distance calibrated spectral energy distributions of a sample of old, young, and field age brown dwarfs of the same effective temperature. In so doing, I will discern observables linked to gravity, atmosphere, metallicity and age effects.

  6. Monoclonal antibodies directed to fucoidan preparations from brown algae.

    Directory of Open Access Journals (Sweden)

    Thomas A Torode

    Full Text Available Cell walls of the brown algae contain a diverse range of polysaccharides with useful bioactivities. The precise structures of the sulfated fucan/fucoidan group of polysaccharides and their roles in generating cell wall architectures and cell properties are not known in detail. Four rat monoclonal antibodies, BAM1 to BAM4, directed to sulfated fucan preparations, have been generated and used to dissect the heterogeneity of brown algal cell wall polysaccharides. BAM1 and BAM4, respectively, bind to a non-sulfated epitope and a sulfated epitope present in the sulfated fucan preparations. BAM2 and BAM3 identified additional distinct epitopes present in the fucoidan preparations. All four epitopes, not yet fully characterised, occur widely within the major brown algal taxonomic groups and show divergent distribution patterns in tissues. The analysis of cell wall extractions and fluorescence imaging reveal differences in the occurrence of the BAM1 to BAM4 epitopes in various tissues of Fucus vesiculosus. In Ectocarpus subulatus, a species closely related to the brown algal model Ectocarpus siliculosus, the BAM4 sulfated epitope was modulated in relation to salinity levels. This new set of monoclonal antibodies will be useful for the dissection of the highly complex and yet poorly resolved sulfated polysaccharides in the brown algae in relation to their ecological and economic significance.

  7. The "Skinny" on brown fat, obesity, and bone. (United States)

    Devlin, Maureen J


    The discovery that metabolically active brown fat is present in humans throughout ontogeny raises new questions about the interactions between thermoregulatory, metabolic, and skeletal homeostasis. Brown adipose tissue (BAT) is distinct from white adipose tissue (WAT) for its ability to burn, rather than store, energy. BAT uniquely expresses uncoupling protein-1 (abbreviated as UCP1), which diverts the energy produced by cellular respiration to generate heat. While BAT is found in small mammals, hibernators, and newborns, this depot was thought to regress in humans during early postnatal life. Recent studies revealed that human BAT remains metabolically active throughout childhood and even in adulthood, particularly in response to cold exposure. In addition to the constitutive BAT depots present at birth, BAT cells can be induced within WAT depots under specific metabolic and climatic conditions. These cells, called inducible brown fat, "brite," or beige fat, are currently the focus of intense investigation as a possible treatment for obesity. Inducible brown fat is associated with higher bone mineral density, suggesting that brown fat interacts with bone growth in previously unrecognized ways. Finally, BAT may have contributed to climatic adaptation in hominins. Here, I review current findings on the role of BAT in thermoregulation, bone growth, and metabolism, describe the potential role of BAT in moderating the obesity epidemic, and outline possible functions of BAT across hominin evolutionary history. © 2014 American Association of Physical Anthropologists.

  8. Lettucenin sesquiterpenes contribute significantly to the browning of lettuce. (United States)

    Mai, Franziska; Glomb, Marcus A


    Wound-induced changes in the composition of secondary plant compounds cause the browning of processed lettuce. Cut tissues near the lettuce butt end clearly exhibit increased formation of yellow-brown pigments. This browning reaction is typically been attributed to the oxidation of polyphenols by the enzyme polyphenol oxidase (PPO). However, in our previous study on Iceberg lettuce, we showed that, besides the enzymatic polyphenol browning, other reactions must be involved in the formation of colored structures. With the present study for the first time, we isolated yellow sesquiterpenes by multilayer countercurrent chromatography (MLCCC), followed by preparative high-performance liquid chromatography (HPLC). Further analyses by nuclear magnetic resonance (NMR) and mass spectrometry (MS) techniques identified lettucenin A and three novel derivatives. We call these compounds lettucenins A1, B, and B1. Color-dilution analyses revealed these lettucenins as key chromophores in the browning of Iceberg lettuce. A time formation curve showed the accumulation of lettucenins A and B within 40 h after cutting. Thereafter, these structures were degraded to unknown colored compounds. Lettucenin A was verified in five varieties of Lactuca. In contrast to that, lettucenin A was present only at trace levels in five varieties of Cichorium. Therefore, lettucenin A might be used as a chemosystematic marker of the genus Lactuca.

  9. Being Black and Brown in the 21st Century

    Directory of Open Access Journals (Sweden)

    Pierre W. Orelus


    Full Text Available Depending on one’s level of understanding and awareness about the plight of Black and Brown people, one might argue that they are better off today than they were 50 years ago or so, especially when one remembers the Jim Crow era during which Black and Brown people were ruthlessly brutalized, particularly by White supremacist groups such as the Klu Klux Kan. However, if one critically analyzed the achievement gap between students of color and their White counterparts, the decline in incomes, and other forms of educational and socioeconomic inequality that Black and Brown people, particularly poor students of color, have been experiencing for the last several decades or so, one would realize that substantially nothing has changed for them. In light of this view, this article explores the educational and socioeconomic conditions of People of Color, including those of linguistically and culturally diverse students. Specifically, it examines the ways and the degree to which lack of resources combined with institutional racism and the legacy of slavery continue to limit the life chances of Black and Brown people in the 21st century. The author ends this article making recommendations to counter inequality in schools and society at large that Black and Brown people have been facing.

  10. Boron uptake, localization, and speciation in marine brown algae. (United States)

    Miller, Eric P; Wu, Youxian; Carrano, Carl J


    In contrast to the generally boron-poor terrestrial environment, the concentration of boron in the marine environment is relatively high (0.4 mM) and while there has been extensive interest in its use as a surrogate of pH in paleoclimate studies in the context of climate change-related questions, the relatively depth independent, and the generally non-nutrient-like concentration profile of this element have led to boron being neglected as a potentially biologically relevant element in the ocean. Among the marine plant-like organisms the brown algae (Phaeophyta) are one of only five lineages of photosynthetic eukaryotes to have evolved complex multicellularity. Many of unusual and often unique features of brown algae are attributable to this singular evolutionary history. These adaptations are a reflection of the marine coastal environment which brown algae dominate in terms of biomass. Consequently, brown algae are of fundamental importance to oceanic ecology, geochemistry, and coastal industry. Our results indicate that boron is taken up by a facilitated diffusion mechanism against a considerable concentration gradient. Furthermore, in both Ectocarpus and Macrocystis some boron is most likely bound to cell wall constituent alginate and the photoassimilate mannitol located in sieve cells. Herein, we describe boron uptake, speciation, localization and possible biological function in two species of brown algae, Macrocystis pyrifera and Ectocarpus siliculosus.

  11. Brown adipose tissue in morbidly obese subjects.

    Directory of Open Access Journals (Sweden)

    Guy H E J Vijgen

    Full Text Available BACKGROUND: Cold-stimulated adaptive thermogenesis in brown adipose tissue (BAT to increase energy expenditure is suggested as a possible therapeutic target for the treatment of obesity. We have recently shown high prevalence of BAT in adult humans, which was inversely related to body mass index (BMI and body fat percentage (BF%, suggesting that obesity is associated with lower BAT activity. Here, we examined BAT activity in morbidly obese subjects and its role in cold-induced thermogenesis (CIT after applying a personalized cooling protocol. We hypothesize that morbidly obese subjects show reduced BAT activity upon cold exposure. METHODS AND FINDINGS: After applying a personalized cooling protocol for maximal non-shivering conditions, BAT activity was determined using positron-emission tomography and computed tomography (PET-CT. Cold-induced BAT activity was detected in three out of 15 morbidly obese subjects. Combined with results from lean to morbidly obese subjects (n = 39 from previous study, the collective data show a highly significant correlation between BAT activity and body composition (P<0.001, respectively explaining 64% and 60% of the variance in BMI (r = 0.8; P<0.001 and BF% (r = 0.75; P<0.001. Obese individuals demonstrate a blunted CIT combined with low BAT activity. Only in BAT-positive subjects (n = 26 mean energy expenditure was increased significantly upon cold exposure (51.5±6.7 J/s versus 44.0±5.1 J/s, P = 0.001, and the increase was significantly higher compared to BAT-negative subjects (+15.5±8.9% versus +3.6±8.9%, P = 0.001, indicating a role for BAT in CIT in humans. CONCLUSIONS: This study shows that in an extremely large range of body compositions, BAT activity is highly correlated with BMI and BF%. BAT-positive subjects showed higher CIT, indicating that BAT is also in humans involved in adaptive thermogenesis. Increasing BAT activity could be a therapeutic target in (morbid obesity.

  12. Susan G. Komen for the Cure (United States)

    ... de sus senos:Consejos útiles para mujeres El Cancer de Mama y el Medio Ambiente: Preguntas y Respuestas Guía de herramientas de educación sobre el cancer de seno para comunidades hispanas/Latinas About Us ...

  13. Entretien avec Susan Holtz | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au seuil du prochain millénaire, le développement planétaire durable pose des défis complexes et d'envergure. Partout dans le monde, on cherche à relever ces défis en intégrant les politiques environnementales, sociales et économiques.

  14. Helminths of brown bears (Ursus arctos) in the Kola Peninsula. (United States)

    Bugmyrin, S V; Tirronen, K F; Panchenko, D V; Kopatz, A; Hagen, S B; Eiken, H G; Kuznetsova, A S


    We present data on the species composition of helminths in brown bears (Ursus arctos) from the Murmansk Region, Russia. The absence of any information about helminths of brown bear in the region necessitated the conduct of these studies. Samples were collected in 2014 and 2015 in the southern part of the Kola Peninsula from the White Sea coastal habitats. Annually, in the study area, 1-3 bears are legally hunted and biological samples for examination are very difficult to obtain. Therefore, we used fecal samples. We studied 93 feces and identified parasite eggs identified in 43 of them by morphometric criteria. The surveys revealed eggs of the following helminths: Dicrocoelium sp., Diphyllobothrium sp., Anoplocephalidae, Capillariidae, Baylisascaris sp., Strongylida 1, and Strongylida 2. These results represent the first reconnaissance stage, which allowed characterizing the taxonomic diversity and prevalence of parasites of brown bears of the Kola Peninsula.

  15. Characterization of the Mysteriously Cool Brown Dwarf HD 4113 (United States)

    Ednie, Michaela; Follette, Katherine; Ward-Duong, Kimberly


    Characterizing the physical properties of brown dwarfs is necessary to expand and improve our understanding of low mass companions, including exoplanets. Systems with both close radial velocity companions and distant directly imaged companions are particularly powerful in understanding planet formation mechanisms. Early in 2017, members of the SPHERE team discovered a companion brown dwarf in the HD 4113 system, which also contains a known RV planet. Atmospheric model fits to the Y and J-band spectra and H2/H3 photometry of the brown dwarf suggested it is unusually cool. We obtained new Magellan data in the Z and K’ bands in mid-2017. This data will help us to complete a more detailed atmospheric and astrometric characterization of this unusually cool companion. Broader wavelength coverage will help in accurate spectral typing and estimations of luminosity, temperature, surface gravity, radius, and composition. Additionally, a second astrometric epoch will help constrain the architecture of the system.

  16. Interspecific variation in total phenolic content in temperate brown algae

    Directory of Open Access Journals (Sweden)

    Anna Maria Mannino


    Full Text Available Marine algae synthesize secondary metabolites such as polyphenols that function as defense and protection mechanisms. Among brown algae, Fucales and Dictyotales (Phaeophyceae contain the highest levels of phenolic compounds, mainly phlorotannins, that play multiple roles. Four temperate brown algae (Cystoseira amentacea, Cystoseira compressa, Dictyopteris polypodioides and Padina pavonica were studied for total phenolic contents. Total phenolic content was determined colorimetrically with the Folin-Ciocalteu reagent. Significant differences in total phenolic content were observed between leathery and sheetlike algae and also within each morphological group. Among the four species, the sheet-like alga D. polypodioides, living in the upper infralittoral zone, showed the highest concentration of phenolic compounds. These results are in agreement with the hypothesis that total phenolic content in temperate brown algae is influenced by a combination of several factors, such as growth form, depth, and exposition to solar radiation.

  17. Brown Tumor Shown Flare Phenomenon On Bone Scan After Parathyroidectomy

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Kwang Ho; Park, Seol Hoon; Baek, So Ra; Chae, Sun Young; Koh, Jung Min; Kim, Jae Seung; Moon, Dae Hyuk; Ryu, Jin Sook [Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)


    Brown tumor is the benign bone lesion consists of woven bone and fibrous tissue without matrix, which develop due to chronic excessive osteoclastic activity such as hyperparathyroidism. Usually they appear with normal uptake or occasionally focally increased uptake on bone scan. We present a case with brown tumor shown more increased uptake and more number of lesions on bone scan after parathyroidectomy, and lesser increased uptake on serial bone scans without any other treatment through several months. This finding is thought to be similar to 'flare phenomenon' which is occasionally seen after treatment of metastatic bone lesions of malignant cancer, and may represent curative process of brown tumor with rapid normal bone formation.

  18. Necrotizing fasciitis developing from a brown recluse spider bite. (United States)

    Majeski, J


    A 20-year retrospective case series was analyzed to identify the brown recluse spider bite as a cause of necrotizing fasciitis. Data from 31 consecutive patients with necrotizing fasciitis were analyzed. Of the 31 patients with necrotizing fasciitis a brown recluse spider bite was found to be the initial cause in two patients. Both patients with spider bites delayed in obtaining medical treatment, and secondary infection of the necrotic tissue occurred. One patient was diagnosed by frozen section tissue biopsy, and the second patient was diagnosed by clinical examination. All patients in this series had immediate aggressive operative debridement. Both patients survived with functional limbs. There were no deaths in this large series. Necrotizing fasciitis can be caused by a secondarily infected brown recluse spider bite. Successful treatment of necrotizing fasciitis from any cause is associated with early diagnosis, immediate surgical debridement, and supplemental enteral or parenteral nutrition.


    Directory of Open Access Journals (Sweden)

    Vlastimil MONI


    Full Text Available This article presents summarizing information about the solution of partial part of research problem of prognoses of deposited brown coal spontaneous combustion sources genesis as a part of project TA01020351 – program ALFA. We will gradually describe the results of long term measurements carried out on selected brown coal heaps realized from 2011 to 2013. The attention is devoted to characterization of key parameters. These parameters influence the genesis of combustion. The second problem is the comparison of results of thermal imaging with laboratory results of gas and coal samples sampled in situ, with the influence of atmospheric conditions (insolation, aeration, rainfall, atmospheric pressure changes etc., with influence of coal mass degradation, physical and chemical factors and another failure factors to brown coal spontaneous combustion processes.

  20. The Genetics of Brown Adipocyte Induction in White Fat Depots

    Directory of Open Access Journals (Sweden)

    Leslie P. Kozak


    Full Text Available Evidence that adult humans have functional brown adipose tissue has stirred interest in the possibility that the impressive effectiveness of induction of brown adipocytes to reduce obesity in mice may be translated to the human condition. A major focus recently on the identification of signaling and transcription factor that stimulate the induction of brown adipocytes has come from transgenic and gene KO models. However, these models have created a very complex picture of the regulatory mechanisms for brown fat induction. In this review insights into the critical regulatory pathways involved in brown adipocyte induction in the retroperitoneal fat depot of mice are described from quantitative trait locus analysis of allelic variability determining Ucp1 levels and brown adipocyte induction in A/J vs B6 mice. The key observation is that recombinant genotypes, found in recombinant inbred stains and backcross and intercross progeny , show transgressive variation for Ucp1 mRNA levels. These genetic crosses also show that the levels of Ucp1 mRNA are determined by interactions that control the levels of PPARα, PGC-1α and type 2 deiodinase and that each factor is controlled by a subset of QTLs that also control Ucp1expression. These results indicate that induction of Ucp1 in the retroperitoneal fat depot involves synergy between signaling and transcription factors that vary depending upon the environmental conditions. Inherent in this model is the idea that there is a high level of redundancy that can involve any factor with the potential to influence expression of the core factors, PPARα, PGC-1a and DIO2.

  1. Regulation of brown adipocyte metabolism by myostatin/follistatin signaling

    Directory of Open Access Journals (Sweden)

    Rajan eSingh


    Full Text Available Obesity develops from perturbations of cellular bioenergetics, when energy uptake exceeds energy expenditure, and represents a major risk factor for the development of type 2 diabetes, dyslipidemia, cardiovascular disease, cancer, and other conditions. Brown adipose tissue (BAT has long been known to dissipate energy as heat and contribute to energy expenditure, but its presence and physiological role in adult human physiology has been questioned for years. Recent demonstrations of metabolically active brown fat depots in adult humans have revolutionized current therapeutic approaches for obesity-related diseases. The balance between white adipose tissue (WAT and BAT affects the systemic energy balance and is widely believed to be the key determinant in the development of obesity and related metabolic diseases. Members of the transforming growth factor-beta (TGF-β superfamily play an important role in regulating overall energy homeostasis by modulation of brown adipocyte characteristics. Inactivation of TGF-β/Smad3/myostatin (Mst signaling promotes browning of white adipocytes, increases mitochondrial biogenesis and protects mice from diet-induced obesity, suggesting the need for development of a novel class of TGF-β/Mst antagonists for the treatment of obesity and related metabolic diseases. We recently described an important role of follistatin (Fst, a soluble glycoprotein that is known to bind and antagonize Mst actions, during brown fat differentiation and the regulation of cellular metabolism. Here we highlight various investigations performed using different in vitro and in vivo models to support the contention that targeting TGF-β/Mst signaling enhances brown adipocyte functions and regulates energy balance, reducing insulin resistance and curbing the development of obesity and diabetes.


    Directory of Open Access Journals (Sweden)

    V. V. Kravchenko


    Full Text Available Methodology for economic evaluation of the effective use of the Belarusian brown coal deposits has been developed on the basis of systematic analysis of scientific, statistical and economic data. The obtained methodology allows to perform multi-variant optimization calculations under various uncertainty level without reduction to the same energy effect that is especially important while developing economic forecasts and programs for the long term perspective. Using this methodology evaluation of various directions pertaining to usage of the Belarusian brown coal has been done and recommendations on their possible application have been given in the paper.

  3. Brown Dwarfs: A New Class of Stellar Lighthouse (United States)


    Brown dwarfs, thought just a few years ago to be incapable of emitting any significant amounts of radio waves, have been discovered putting out extremely bright "lighthouse beams" of radio waves, much like pulsars. A team of astronomers made the discovery using the National Science Foundation's Very Large Array (VLA) radio telescope. Artist's Conception of Brown Dwarf Artist's conception of "mini-aurorae" at poles of brown dwarf, producing beams of strong radio emission. CREDIT: Hallinan et al., NRAO/AUI/NSF Click on image for page of graphics and full information "These beams rotate with the brown dwarf, and we see them when the beam passes over the Earth. This is the same way we see pulses from pulsars," said Gregg Hallinan of the National University of Ireland Galway. "We now think brown dwarfs may be a missing link between pulsars and planets in our own Solar System, which also emit, but more weakly," he added. Brown dwarfs are enigmatic objects that are too small to be stars but too large to be planets. They are sometimes called "failed stars" because they have too little mass to trigger hydrogen fusion reactions at their cores, the source of the energy output in larger stars. With roughly 15 to 80 times the mass of Jupiter, the largest planet in our Solar System, brown dwarfs were long thought to exist. However, it was not until 1995 that astronomers were able to actually find one. A few dozen now are known. In 2001, a group of summer students at the National Radio Astronomy Observatory used the VLA to observe a brown dwarf, even though they had been told by seasoned astronomers that brown dwarfs are not observable at radio wavelengths. Their discovery of a strong flare of radio emission from the object surprised astronomers and the students' scientific paper on the discovery was published in the prestigous scientific journal Nature. Hallinan and his team observed a set of brown dwarfs with the VLA last year, and found that three of the objects emit extremely

  4. Brown recluse spider bite to the upper lip. (United States)

    Dare, Ryan K; Conner, Kelly B; Tan, Poliana C; Hopkins, Robert H


    Brown recluse spiders are predominantly found in south central United States. Their bites usually cause mild self-limiting reactions, although localized tissue necrosis and rare systemic, potentially fatal, envenomations are known to occur. Herein, we report an atypical presentation of a brown recluse bite in a 20 year old female who was admitted to the intensive care unit due to angioedema and cellulitis. We photographically document the bite site for twenty-four hours following envenomation. She received glucocorticoids, antihistamines, antibiotics and dapsone while hospitalized and was subsequently discharged with complete resolution of symptoms without the development of tissue necrosis or scarring.

  5. Brown-McLean Syndrome in a Pediatric Patient

    Directory of Open Access Journals (Sweden)

    Abdo Karim Tourkmani


    Full Text Available The purpose of this manuscript is to report the case of a 12-year-old patient who presented for routine ophthalmic examination after congenital cataract surgery performed at 2 months of age. The patient was diagnosed with bilateral Brown-McLean syndrome by slit lamp examination. No treatment was required because the patient was asymptomatic and had a clear central cornea. This is the first described case of Brown-McLean syndrome in a pediatric patient, representing the importance of clinical examination in the pediatric age group after cataract surgery because of the risk for patients of developing peripheral edema.

  6. Mechanisms and effective control of physiological browning phenomena in plant cell cultures. (United States)

    Dong, Yan-Shan; Fu, Chun-Hua; Su, Peng; Xu, Xiang-Ping; Yuan, Jie; Wang, Sheng; Zhang, Meng; Zhao, Chun-Fang; Yu, Long-Jiang


    Browning phenomena are ubiquitous in plant cell cultures that severely hamper scientific research and widespread application of plant cell cultures. Up to now, this problem still has not been well controlled due to the unclear browning mechanisms in plant cell cultures. In this paper, the mechanisms were investigated using two typical materials with severe browning phenomena, Taxus chinensis and Glycyrrhiza inflata cells. Our results illustrated that the browning is attributed to a physiological enzymatic reaction, and phenolic biosynthesis regulated by sugar plays a decisive role in the browning. Furthermore, to confirm the specific compounds which participate in the enzymatic browning reaction, transcriptional profile and metabolites of T. chinensis cells, and UV scanning and high-performance liquid chromatography-mass spectrometry (HPLC-MS) profile of the browning compounds extracted from the brown-turned medium were analyzed, flavonoids derived from phenylpropanoid pathway were found to be the main compounds, and myricetin and quercetin were deduced to be the main substrates of the browning reaction. Inhibition of flavonoid biosynthesis can prevent the browning occurrence, and the browning is effectively controlled via blocking flavonoid biosynthesis by gibberellic acid (GA3 ) as an inhibitor, which further confirms that flavonoids mainly contribute to the browning. On the basis above, a model elucidating enzymatic browning mechanisms in plant cell cultures was put forward, and effective control approaches were presented. © 2015 Scandinavian Plant Physiology Society.


    Energy Technology Data Exchange (ETDEWEB)

    Reipurth, Bo [Institute for Astronomy and NASA Astrobiology Institute University of Hawaii, 640 N. Aohoku Place, Hilo, HI 96720 (United States); Mikkola, Seppo, E-mail:, E-mail: [Tuorla Observatory, University of Turku, Väisäläntie 20, Piikkiö (Finland)


    Binaries in which both components are brown dwarfs (BDs) are being discovered at an increasing rate, and their properties may hold clues to their origin. We have carried out 200,000 N-body simulations of three identical stellar embryos with masses drawn from a Chabrier IMF and embedded in a molecular core. The bodies are initially non-hierarchical and undergo chaotic motions within the cloud core, while accreting using Bondi–Hoyle accretion. The coupling of dynamics and accretion often leads to one or two dominant bodies controlling the center of the cloud core, while banishing the other(s) to the lower-density outskirts, leading to stunted growth. Eventually each system transforms either to a bound hierarchical configuration or breaks apart into separate single and binary components. The orbital motion is followed for 100 Myr. In order to illustrate 200,000 end-states of such dynamical evolution with accretion, we introduce the “triple diagnostic diagram,” which plots two dimensionless numbers against each other, representing the binary mass ratio and the mass ratio of the third body to the total system mass. Numerous freefloating BD binaries are formed in these simulations, and statistical properties are derived. The separation distribution function is in good correspondence with observations, showing a steep rise at close separations, peaking around 13 AU and declining more gently, reaching zero at separations greater than 200 AU. Unresolved BD triple systems may appear as wider BD binaries. Mass ratios are strongly peaked toward unity, as observed, but this is partially due to the initial assumptions. Eccentricities gradually increase toward higher values, due to the lack of viscous interactions in the simulations, which would both shrink the orbits and decrease their eccentricities. Most newborn triple systems are unstable and while there are 9209 ejected BD binaries at 1 Myr, corresponding to about 4% of the 200,000 simulations, this number has grown to



    Shah, Nilesh; Dave, Kirti


    The authors compared the serum acetylcholinesterase level in the patients of brown sugar dependence and the normal volunteers. Significantly lower level of serum acetylcholinesterase was found in patients of brown sugar dependence.

  9. Brown v. Board of Education and School Desegregation: An Analysis of Selected Litigation


    Brown, Lynn T.


    BROWN V. BOARD OF EDUCATION AND SCHOOL DESEGREGATION: AN ANALYSIS OF SELECTED LITIGATION Lynn T. Brown (ABSTRACT) Brown is often regarded among the most monumental decisions ever rendered by the United States Supreme Court. Its legacy includes a body of case law affecting the shape and meaning of school desegregation over the past fifty years. However, school desegregation and the transition of Brown from courtroom jurisprudence to a manifestation of equal educational opport...

  10. Vocalisations of the Brown-headed Parrot, Poicephalus cryptoxanthus

    African Journals Online (AJOL)

    The Brown-headed Parrot, Poicephalus cryptoxanthus, is a poorly-known species inhabiting eastern South Africa. This study details the vocalizations of the species and places these in their behavioural context. Seven distinct calls were identified. The magnitude of the vocabulary corresponds well with those that have been ...

  11. The "brown" environmental agenda and the constitutional duties of ...

    African Journals Online (AJOL)

    This discussion subsequently feeds into the argument that South Africa's constitutional environmental right also foresees the advancement of the brown environmental agenda, which has implications for the interpretation and enforcement of local government's service delivery mandate. This link between municipal service ...

  12. Evidence for cleavage of lignin by a brown rot basidiomycete (United States)

    Daniel J. Yelle; John Ralph; Fachuang Lu; Kenneth E. Hammel


    Biodegradation by brown-rot fungi is quantitatively one of the most important fates of lignocellulose in nature. It has long been thought that these basidiomycetes do not degrade lignin significantly, and that their activities on this abundant aromatic biopolymer are limited to minor oxidative modifications. Here we have applied a new technique for the complete...

  13. Screening and characterization a RAPD marker of tobacco brown ...

    African Journals Online (AJOL)

    RAPD) methods were used to analyze F2 individuals of 82-3041 × Yunyan 84 to screen and characterize the molecular marker linked to brown-spot resistant gene. A total of 800 arbitrary decamer oligonucleotide primers were used for RAPD ...

  14. Short Note DNA sequences from the Little Brown Bustard Eupodotis ...

    African Journals Online (AJOL)

    Taxonomic classification of birds based exclusively on morphology and plumage traits has often been found to be inconsistent with true evolutionary history when tested with molecular phylogenies based on neutrally evolving markers. Here we present cytochrome-b gene sequences for the poorly known Little Brown ...

  15. (Stanley, 2006; Brown, 2003; Shannon, 1997; etc) have established ...

    African Journals Online (AJOL)


    Similar problem has been envisaged around the globe ... global trend which addresses issues concerning environ- mental impacts. .... Generation of 1 kWh of electricity with biogas/diesel mixture. 700. Source: Brown (2003). Figure 9. Modified gas stove and pressure lamp attached to biogas storage container. Source: Forst ...

  16. PICTORIAL ESSAY Traumatic Brown-Sequard syndrome– clinico ...

    African Journals Online (AJOL)

    A 34-year-old man presented with a history of a stab wound to the left side of the neck. Physical examination revealed an ipsilateral left-sided hemiplegia and contralateral loss of sensation. A clinical diagnosis of. Brown-Sequard syndrome was made. Magnetic resonance imaging. (MRI) findings demonstrated ...

  17. "Brown," Political Economy, and the Scientific Education of African Americans (United States)

    Tate, William F., IV


    The goals of this chapter are threefold. The first goal is to examine the scientific attainment of African Americans in the post-"Brown" era. The term scientific attainment is used here to describe more broadly mathematics and scientific achievement as measured in trend studies, academic coursework, and degrees. A second, related goal is…

  18. Halogenated terpenoids from the brown alga Padina tetrastromatica (HAUCK)

    Digital Repository Service at National Institute of Oceanography (India)

    Parameswaran, P.S.; Bhat, K.L.; Das, B.; Kamat, S.Y.; Harnos, S.

    ranging from 14:0 to 22:0 with palmitic acid (16:0, 67.4%) and oleic acid (18:1, 17.1%) being the major constituents, have been isolated from the pet, ether soluble fraction of the methanol extract of the brown alga Padina tetrastromatica...

  19. Considerations on the etiology of congenital Brown syndrome. (United States)

    Coussens, Tracey; Ellis, Forrest J


    Brown syndrome is an ocular motility disorder characterized by limited volitional and passive elevation of the eye in adduction. Although originally thought due to abnormalities in the trochlea or tendon sheath (limiting the free movement of the tendon through the trochlea), recent evidence suggests that some cases of congenital Brown syndrome may be related to neurodevelopmental abnormalities of the extraocular muscles (congenital cranial dysinnervation disorders, CCDD). CCDD is a term encompassing congenital abnormalities of eye movements caused by congenital innervational abnormalities. The abnormal development of cranial nerve nuclei or abnormalities in cranial nerve axonal transport affects the development of the extraocular muscle(s). Currently, congenital fibrosis of the extraocular muscles, Duane syndrome, Moebius syndrome, Horizontal gaze palsy and progressive scoliosis, and synergistic divergence are included as CCDDs. In addition, congenial ptosis, Jaw Wink ptosis, and congenital superior oblique palsy are also included. Recently, it has been suggested that some cases of congenital Brown syndrome and congenital superior oblique paresis are related, and these entities may be part of the CCDDs spectrum. Important findings regarding the cause of congenital Brown syndrome will be reviewed.

  20. Cassava brown streak disease effects on leaf metabolites and ...

    African Journals Online (AJOL)

    Cassava Brown Streak Disease (CBSD) is a threat to productivity and product quality in East Africa. The objective of this study was to understand the effect of CBSD on the primary photosynthetic apparatus of cassava (Manihot esculenta Crantz). Three cassava varieties with varying levels of reaction to infection by CBSD ...

  1. User-Centered Design in Practice: The Brown University Experience (United States)

    Bordac, Sarah; Rainwater, Jean


    This article presents a case study in user-centered design that explores the needs and preferences of undergraduate users. An analysis of LibQual+ and other user surveys, interviews with public service staff, and a formal American with Disabilities Act accessibility review served as the basis for planning a redesign of the Brown University…

  2. The scent marking behaviour of the brown hyaena Hyaena brunnea ...

    African Journals Online (AJOL)

    The deposition onto grass stalks of two distinct, strongsmelling substances produced in the anal scent pouch, is the most common form of scent marking in the brown hyaena (Hyaena brunnea). It is called pasting. The behaviour associated with pasting is described, as is the related functional anatomy of the scent pouch.

  3. Stylistic Analysis of Robert Browning's Poem "Patriot into Traitor (United States)

    Ahmed, Mumtaz; Irshad, Ayesha


    The stylistic analysis of Robert Browning's poem "Patriot into Traitor" is done by using graphological, phonological, morphological and lexico-syntactic patterns. This analysis is helpful in decoding the underlying meanings of the poem. It clearly brings to surface what the poet really wants to impart.

  4. Beyond brown: polyphenol oxidases as enzymes of plant specialized metabolism (United States)

    Most cloned and/or characterized plant polyphenol oxidases (PPOs) have catecholase activity (i.e., they oxidize o-diphenols to o-quinones) and are localized or predicted to be localized to plastids. As a class, they have broad substrate specificity and are associated with browning of produce and oth...

  5. A case of multiple brown tumors with primary hyperparathyroidism. (United States)

    Mori, Hiroko; Okada, Yosuke; Arao, Tadashi; Shimaziri, Shohei; Tanaka, Yoshiya


    We report a case of large multiple brown tumors in a patient with primary hyperparathyroidism. A 52-year-old woman suffered from pain in the ribs and developed left facial swelling and deformity. CT showed a large destructive osteolytic lesion in the left maxillary sinus. Biopsy showed a lesion with newly formed bone tissue, diffuse giant cells and deposits of hemosiderin. In addition, similar lesions were also observed in the ribs, iliac bones and pelvis. The laboratory data showed hypercalcemia and hyperparathyroidism. Cervical echo and (201)Tl-(99m)TcO(4-) scintigraphy demonstrated a right lower swollen parathyroid adenoma. The diagnosis was multiple brown tumors with primary hyperparathyroidism and parathyroidectomy was performed. Follow-up CT showed marked decreases in the size of osteolytic lesions with calcification in the brown tumors compared to pre-treatment findings. These changes were associated with marked improvement in pain and facial deformity. We described a rare case of multiple brown tumors appeared in the maxilla associated with primary hyperparathyroidism.

  6. Primary hyperparathyroidism with rare presentation as multiple brown tumours

    Directory of Open Access Journals (Sweden)

    Smit Doshi


    Full Text Available We present a case of primary hyperparathyroidism with an uncommon presentation as multiple brown tumours, which may easily be mistaken for a primary bone neoplasm. A brief literature review and its clinical and surgical management are also discussed here.

  7. Peripheral plasma protein and progesterone profile in brown ...

    African Journals Online (AJOL)

    Experiment was done to determine total protein (TP) in eight multiparous Brown Savannah goats between two weeks preparturm and seven weeks post-partum. The mean value of plasma total protein, 8.17 ± 0.62 gm% obtained two weeks before parturition was higher than normal range of 6.0-7.5 gm% for caprine species.

  8. The Mechanism of White and Brown Adipocyte Differentiation

    Directory of Open Access Journals (Sweden)

    Hironori Nakagami


    Full Text Available Obesity gives vent to many diseases such as type 2 diabetes, hypertension, and hyperlipidemia, being considered as the main causes of mortality and morbidity worldwide. The pathogenesis and pathophysiology of metabolic syndrome can well be understood by studying the molecular mechanisms that control the development and function of adipose tissue. In human body, exist two types of adipose tissue, the white and the brown one, which are reported to play various roles in energy homeostasis. The major and most efficient storage of energy occurs in the form of triglycerides in white adipose tissue while brown adipose tissue actively participates in both basal and inducible energy consumption in the form of thermogenesis. Recent years have observed a rapid and greater interest towards developmental plasticity and therapeutic potential of stromal cells those isolated from adipose tissue. The adipocyte differentiation involves a couple of regulators in the white or brown adipogenesis. Peroxisome proliferators-activated receptor-γ actively participates in regulating carbohydrate and lipid metabolism, and also acts as main regulator of both white and brown adipogenesis. This review based on our recent research, seeks to highlight the adipocyte differentiation.

  9. Effective production of fermentable sugars from brown macroalgae biomass. (United States)

    Wang, Damao; Kim, Do Hyoung; Kim, Kyoung Heon


    Brown macroalgae are renewable and sustainable biomass resources for the production of biofuels and chemicals, owing to their high levels of carbohydrates and low levels of lignin. To increase the biological usage of brown macroalgae, it is necessary to depolymerize the polysaccharides that generate macroalgal monomeric sugars or sugar derivatives and to convert them into fermentable sugars for the production of biofuels and chemicals. In this review, we discuss the chemical and enzymatic saccharification of the major carbohydrates found in brown macroalgae and the use of the resulting constituents in the production of biofuels and chemicals, as well as high-value health-benefiting functional oligosaccharides and sugars. We also discuss recently reported experimental results, novel enzymes, and technological breakthroughs that are related to polysaccharide depolymerization, fermentable sugar production, and the biological conversion of non-favorable sugars for fermentation using industrial microorganisms. This review provides a comprehensive perspective of the efficient utilization of brown macroalgae as renewable resources for the production of biofuels and chemicals.

  10. Enzymatic Browning in Sugar Beet Leaves (Beta vulgaris L.)

    NARCIS (Netherlands)

    Vissers, Anne; Kiskini, Alexandra; Hilgers, Roelant; Marinea, Marina; Wierenga, Peter Alexander; Gruppen, Harry; Vincken, Jean Paul


    Sugar beet (Beta vulgaris L.) leaves of 8 month (8m) plants showed more enzymatic browning than those of 3 month (3m). Total phenolic content increased from 4.6 to 9.4 mg/g FW in 3m and 8m, respectively, quantitated by

  11. Gastrointestinal tract of the brown kiwi (Apteryx mantelli)

    NARCIS (Netherlands)

    Potter, M.A.; Lentle, R.G.; Birtles, M.J.; Thomas, D.; Hendriks, W.H.


    The caeca of the brown kiwi Apteryx mantelli increased in length isometrically with body mass, but wall mass and thus mucosal thickness increased allometrically. Kiwi caeca are sacculate, with greater thickness of mucosa in the proximal portions. The caecal mucosa is similar to the small intestinal

  12. Evaluating damage to nursery crops by brown marmorated stink bug (United States)

    Halyomorpha halys, commonly known as the brown marmorated stink bug (BMSB), has become a major pest and nuisance since it arrived in the US in 1998 for both agricultural growers and homeowners. They can feed on ~200 different plant species, several of which are important ornamental crop species. The...

  13. "Brown" at 62: School Segregation by Race, Poverty and State (United States)

    Orfield, Gary; Ee, Jongyeon; Frankenberg, Erica; Siegel-Hawley, Genevieve


    As the anniversary of "Brown v. Board of Education" decision arrives again without any major initiatives to mitigate spreading and deepening segregation in the nation's schools, the Civil Rights Project adds to a growing national discussion with a research brief drawn from a much broader study of school segregation to be published in…

  14. A Commentary: "Brown v. Board of Education I: A Reconsideration" (United States)

    Outlaw, Lucius T., Jr.


    This article, a reconsidering of both the benefits and the consequences of the Brown v. Board of Education (1954; Davis and Graham, 1995) case, posits determinations as to the historical significance of the U.S. Supreme Court justices' decision. Carefully weighing the words of the justices renders a position that the decision of the Court and the…

  15. Public School Administration and "Brown v. Board of Education" (United States)

    Hunter, Richard C.


    This article reviews educational initiatives of state and federal government that were designed to remedy the effects of racial segregation on Black public school students in the United States after the famous "Brown v. Board of Education" decisions. Several policy and legal initiatives are reviewed, including school desegregation,…

  16. Generalised Brown Clustering and Roll-up Feature Generation

    DEFF Research Database (Denmark)

    Derczynski, Leon; Chester, Sean


    Brown clustering is an established technique, used in hundreds of computational linguistics papers each year, to group word types that have similar distributional information. It is unsupervised and can be used to create powerful word representations for machine learning. Despite its improbable...

  17. Factors influencing the spawning migration of female anadromous brown trout

    DEFF Research Database (Denmark)

    Svendsen, Jon Christian; Koed, Anders; Aarestrup, Kim


    Radio telemetry was employed to study movements of adult female anadromous brown trout Salmo trutta (sea trout) during upstream spawning migration and following spawning in a stream with tributaries. Sea trout were monitored by manual tracking and by automatic listening stations. The latter sugge...

  18. Insecticide assays against the brown stink bug feeding on pecan (United States)

    The brown stink bug, Euschistus servus (Say) (Hemiptera: Pentatomidae), is an economic pest of pecan, Carya illinoinensis (Wangenh) K. Koch (Juglandaceae), and other agronomic crops across the southeastern U.S. Management of this pest is mainly via insecticides. Many commercial products indicate o...

  19. Pyrolysis of brown coals of the Lelchitsy deposit (United States)

    Lishtvan, I. I.; Falyushin, P. L.; Kraiko, V. M.; Dudarchik, V. M.


    Results of experimental studies on pyrolysis of brown coals of the Lelchitsy deposit, which were conducted on Laboratory setups in stationary and moving layers for producing high-caloric energy carriers, are presented. The yield of the pyrolysis products is determined; the chemical composition of solid, liquid, and gaseous products of thermochemical treatment is considered.

  20. Genomic inbreeding and relationships among Holsteins, Jerseys, and Brown Swiss (United States)

    Genomic measures of relationship and inbreeding within and across breeds were compared with pedigree measures using genotypes for 43,385 loci of 25,219 Holsteins, 3,068 Jerseys, and 872 Brown Swiss. Adjustment factors were estimated for means and regressions of genomic on pedigree relationships, for...

  1. Comparison of proximate and fatty acid compositions of wild brown ...

    African Journals Online (AJOL)

    The purpose of this study was to compare the fatty acid and proximate composition of two commercially exploited trout species (wild brown trout (WBT) and farmed rainbow trout (FRT)). The mean crude lipid content in FRT (4.3%) was significantly higher than that in WBT (2.7%). Total saturated fatty acid concentration ...

  2. Morphometric Study of Musanga cecropioides R. Brown and ...

    African Journals Online (AJOL)

    Morphometric or Numerical taxonomic analysis of 56 quantitative and qualitative characters, obtained from Musanga cecropioides R. Brown and five species of Myrianthus, M. arboreus Palisot de Beauvois, M. holstii Engler, M. libericus Rendle, M. preusii Engler and M. serratus (Trecul) Bentham was carried out by ...

  3. Social organization of the golden brown mouse lemur (Microcebus ravelobensis)

    NARCIS (Netherlands)

    Weidt, A.; Hagenah, N.; Randrianambinina, B.; Radespiel, U.


    Our study provides the first data on the social organization of the golden brown mouse lemur, a nocturnal primate discovered in northwestern Madagascar in 1994. The study was carried out in two 6-month field periods during the dry season, covering time before and during the mating season. The

  4. Follow-up of MARVELS Brown Dwarf Candidates using EXPERT (United States)

    Ma, Bo; Ge, Jian; Li, Rui; Sithajan, Sirinrat; Thomas, Neil; Wang, Ji; De Lee, Nathan


    The SDSS-III MARVELS survey is a comprehensive radial velocity survey of 3,300 nearby F-K stars, between 7.6 < V < 12.0 in 2008-2012. All of the survey data for 2580 FGK stars from the first two and half years have been processed with the latest data pipeline. A total of 26 new brown dwarfs (BD) candidates have been identified in the processed RV data. We expect to have 8 more BD candidates from the ~800 stars currently under processing, which will make a total of 34 BD candidates. This proposal requests KPNO 2.1m telescope time with the EXPERT instrument, to follow up all of these BD candidates to confirm the detections and characterize the orbits. The results will be used to (1) reveal the overall distribution of the new BDs in the parameter space; (2) measure the occurrence rate of BD around FGK type stars; (3) measure dryness of the brown dwarf desert around stars with different mass and metallicity; (4) constrain theoretical models regarding the formation of brown dwarfs; (5) confirm the discovery of `desert in the brown dwarf desert'; (6) identify additional companions associated with the detected systems.

  5. Performance, Health and Growth of Brown Swiss Calves Fed ...

    African Journals Online (AJOL)


    Abstract. To compare growth performance of Brown Swiss calves fed acidified milk replacer (AMR) at 8% of birth weight, 20 newborn calves were reared under a new calf-feeding programme. Body weights, total weight gains and gains in body measurements, feed intake and feed efficiency values determined at different.

  6. Controversies or Consistencies? A Reply to Brown and Weiner. (United States)

    Covington, Martin V.; Omelich, Carol L.


    This rejoinder to Brown and Weiner (TM 509 074) attempts to resolve areas of apparent conflict and to offer a broad synthesis around the self-worth theory of achievement motivation. The different yet compatible aspects of attribution and self-worth theories in regards to achievement effort are discussed. (BS)

  7. William Faulkner: No Friend of Brown v. Board of Education. (United States)

    Polsgrove, Carol


    In the years following the Supreme Court's Brown v. Board of Education decision to integrate America's public schools, William Faulkner, Norman Mailer, Hannah Arendt, Robert Penn Warren, and, to a lesser extent, C. Vann Woodward, provided intellectual sustenance to southern efforts to resist racial integration. Focuses on Faulkner's political…

  8. Screening lowland rice varieties for resistance to brown spot ...

    African Journals Online (AJOL)

    Twelve lowland rice varieties (BG 90-2, Cisadane, FARO 12, FARO 15 (early maturing), FARO 15 (late maturing), IR 5, ITA 123, ITA 306, MAS 2401, Suakoko 8 and TOS 2578) were planted in 2008 and 2009 growing seasons in Enyong creek rice field in Akwa Ibom State. The varieties were screened for resistance to brown ...

  9. Complete Plastid Genome Sequence of the Brown Alga Undaria pinnatifida.

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    Full Text Available In this study, we fully sequenced the circular plastid genome of a brown alga, Undaria pinnatifida. The genome is 130,383 base pairs (bp in size; it contains a large single-copy (LSC, 76,598 bp and a small single-copy region (SSC, 42,977 bp, separated by two inverted repeats (IRa and IRb: 5,404 bp. The genome contains 139 protein-coding, 28 tRNA, and 6 rRNA genes; none of these genes contains introns. Organization and gene contents of the U. pinnatifida plastid genome were similar to those of Saccharina japonica. There is a co-linear relationship between the plastid genome of U. pinnatifida and that of three previously sequenced large brown algal species. Phylogenetic analyses of 43 taxa based on 23 plastid protein-coding genes grouped all plastids into a red or green lineage. In the large brown algae branch, U. pinnatifida and S. japonica formed a sister clade with much closer relationship to Ectocarpus siliculosus than to Fucus vesiculosus. For the first time, the start codon ATT was identified in the plastid genome of large brown algae, in the atpA gene of U. pinnatifida. In addition, we found a gene-length change induced by a 3-bp repetitive DNA in ycf35 and ilvB genes of the U. pinnatifida plastid genome.

  10. Indirect benefits for female salmon from mating with brown trout. (United States)

    Castillo, Ana G F; Beall, Edward; Morán, Paloma; Martinez, Jose L; Garcia-Vazquez, Eva


    By genetic analysis of 1625 samples from 10 south European rivers, we have found that Atlantic salmon Salmo salar hybridize with sympatric brown trout S. trutta in the wild and provide the female in most heterospecific crosses. Hybrids exhibit reduced fertility and could be considered a wasted reproductive effort by salmon females. In 7 experiments involving salmon females, large brown trout males, and small salmon male sneakers, reproductive success of Atlantic salmon females mating with brown trout males was not significantly different from that of 5 experiments of females mating with conspecific males because small Atlantic salmon sneakers fertilized most ova (mean 93%) in salmon x trout matings. Although egg retention tended to be higher in heterospecific than in conspecific crosses (mean 5.7% vs. 20.5% respectively), mean offspring survival was 24.4% and 30.3%, respectively (t = 1.5 x 10(-8), not significant). Brown trout males taking on a courting role may benefit late-maturing females in absence or scarcity of anadromous salmon males because they play a protective role against disturbances from other fishes (including cannibal sneakers).

  11. Egg Quality Characteristics Of Isa – Brown Layers Fed Brewers ...

    African Journals Online (AJOL)

    Eggs laid by Isa-brown layers were used in this study to investigate the effect of partial substitution of biodegraded brewers' dried grains (BDG) for maize on egg quality parameters of laying hens. A total of 1,728 eggs were used for this study which spanned over a period of 84 days. Eggs were collected from laying birds fed ...

  12. Use of sodium metasilicate for management of peach brown rot

    Directory of Open Access Journals (Sweden)

    Elizandra Pivotto Pavanello


    Full Text Available Peach brown rot, caused by the Monilinia fructicola fungus, is the main disease affecting peach crops, and it is mainly controlled via frequent fungicide applications. This study aimed at searching for alternatives to the intensive use of chemicals, evaluating silicon doses to control pre and postharvest peach brown rot and their influence on maturation parameters and fruit quality. Treatments consisted of control (water and sodium metasilicate doses (2 g L-1, 4 g L-1, 6 g L-1, 8 g L-1 and 10 g L-1 of water. The following assessments were made: spore germination and in vitro mycelial growth, brown rot incidence, soluble solids, titratable acidity, flesh firmness, total polyphenol content and fruit ethylene production and respiration rate. The 2 g L-1 dose reduced spore germination by 95 %. Doses of 6 g L-1 and 8 g L-1 satisfactorily reduced the disease incidence in the field, with 77 % and 89.2 % control, respectively. Sodium metasilicate resulted in the maintenance of great fruit firmness, reduced respiration and ethylene production and increased total polyphenol synthesis, but it did not influence the titratable acidity or soluble solids. Applying 6 g L-1 may potentially control pre and postharvest peach brown rot, besides increasing the total polyphenol synthesis and maintaining a higher flesh firmness.

  13. Extension of gray-brown mouse lemur ( Microcebus griseorufus ...

    African Journals Online (AJOL)

    Extension of gray-brown mouse lemur (Microcebus griseorufus) activity period in a disturbed forest in southwestern Madagascar. K Fish ... lemur activity period in the unfenced forest may be due to differences in forest composition resulting in higher travel costs or a loss of canopy cover which may limit their use of torpor.

  14. Brown dwarf Atmosphere Monitoring (BAM): Characterizing the Coolest Atmosphere (United States)

    Patience, Jennifer


    Using the G141 WFC3/IR grism, we propose a HST spectrophotometric monitoring study of the coolest variable brown dwarf (~650K) identified as part of our Brown dwarf Atmosphere Monitoring (BAM) program. The proposed observations will enable exploration of the dynamic atmospheric evolution of a benchmark T8.5 binary brown dwarf system, which we have discovered to exhibit the second-largest amplitude variation amongst all currently known brown dwarf variables. The close binarity of this system requires the exquisite stability of the HST point spread function to enable resolved monitoring of both components and to discriminate the source of the variability - the second component is a planetary mass object based on evolutionary models. This BAM follow-up study is designed to characterize both the longitudinal and vertical structure of the atmospheric properties of this system via multi-wavelength observations covering the entire spectral range of the WFC3/IR detector. Additionally, by monitoring the target over two separate epochs we will measure the evolution of atmospheric features giving rise to the flux variations. The proposed program will provide a comprehensive dataset serving as a benchmark comparison to directly imaged planets, intensely irradiated Hot Jupiters, and synthetic atmospheric models incorporating different physical processes.

  15. File list: ALL.Adp.20.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Adp.20.AllAg.Brown_preadipocytes mm9 All antigens Adipocyte Brown preadipocytes...RX341044,SRX341420,SRX341421,SRX341046,SRX478161,SRX341027 ...

  16. File list: Pol.Adp.50.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Adp.50.AllAg.Brown_preadipocytes mm9 RNA polymerase Adipocyte Brown SRX341031,SRX341032,SRX341029,SRX341030 ...

  17. File list: NoD.Adp.10.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Adp.10.AllAg.Brown_preadipocytes mm9 No description Adipocyte Brown ...

  18. File list: ALL.Adp.50.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Adp.50.AllAg.Brown_preadipocytes mm9 All antigens Adipocyte Brown preadipocytes...RX341420,SRX341421,SRX341046,SRX478161,SRX341027,SRX478160 ...

  19. File list: Oth.Adp.10.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Adp.10.AllAg.Brown_preadipocytes mm9 TFs and others Adipocyte Brown preadipocyt...341763,SRX341767,SRX341419,SRX341028,SRX341766 ...

  20. File list: Oth.Adp.20.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Adp.20.AllAg.Brown_preadipocytes mm9 TFs and others Adipocyte Brown preadipocyt...341023,SRX341760,SRX341767,SRX341763,SRX341027 ...

  1. File list: InP.Adp.10.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Adp.10.AllAg.Brown_preadipocytes mm9 Input control Adipocyte Brown preadipocyte...058,SRX341056,SRX478161 ...

  2. File list: His.Adp.50.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Adp.50.AllAg.Brown_preadipocytes mm9 Histone Adipocyte Brown preadipocytes SRX3...RX341421,SRX341046,SRX478160 ...

  3. File list: InP.Adp.50.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Adp.50.AllAg.Brown_preadipocytes mm9 Input control Adipocyte Brown preadipocyte...056,SRX341058,SRX478161 ...

  4. File list: DNS.Adp.20.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Adp.20.AllAg.Brown_preadipocytes mm9 DNase-seq Adipocyte Brown preadipocytes ...

  5. File list: InP.Adp.20.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.Adp.20.AllAg.Brown_preadipocytes mm9 Input control Adipocyte Brown preadipocyte...782,SRX341056,SRX478161 ...

  6. File list: ALL.Adp.05.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Adp.05.AllAg.Brown_preadipocytes mm9 All antigens Adipocyte Brown preadipocytes...RX341419,SRX341767,SRX341421,SRX478161,SRX341039,SRX341040 ...

  7. File list: DNS.Adp.10.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Adp.10.AllAg.Brown_preadipocytes mm9 DNase-seq Adipocyte Brown preadipocytes ...

  8. File list: ALL.Adp.10.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Adp.10.AllAg.Brown_preadipocytes mm9 All antigens Adipocyte Brown preadipocytes...RX341420,SRX478161,SRX478160,SRX341040,SRX341041,SRX341039 ...

  9. File list: Pol.Adp.20.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Adp.20.AllAg.Brown_preadipocytes mm9 RNA polymerase Adipocyte Brown SRX341031,SRX341032,SRX341029,SRX341030 ...

  10. File list: His.Adp.20.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Adp.20.AllAg.Brown_preadipocytes mm9 Histone Adipocyte Brown preadipocytes SRX3...RX341420,SRX341421,SRX341046 ...

  11. File list: Pol.Adp.05.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Adp.05.AllAg.Brown_preadipocytes mm9 RNA polymerase Adipocyte Brown SRX341031,SRX341032,SRX341029,SRX341030 ...

  12. File list: NoD.Adp.50.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Adp.50.AllAg.Brown_preadipocytes mm9 No description Adipocyte Brown ...

  13. File list: Pol.Adp.10.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pol.Adp.10.AllAg.Brown_preadipocytes mm9 RNA polymerase Adipocyte Brown SRX341031,SRX341032,SRX341029,SRX341030 ...

  14. File list: His.Adp.05.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Adp.05.AllAg.Brown_preadipocytes mm9 Histone Adipocyte Brown preadipocytes SRX3...RX341421,SRX341039,SRX341040 ...

  15. File list: DNS.Adp.05.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Adp.05.AllAg.Brown_preadipocytes mm9 DNase-seq Adipocyte Brown preadipocytes ...

  16. File list: Oth.Adp.05.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Adp.05.AllAg.Brown_preadipocytes mm9 TFs and others Adipocyte Brown preadipocyt...341766,SRX341418,SRX341023,SRX341419,SRX341767 ...

  17. File list: NoD.Adp.20.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Adp.20.AllAg.Brown_preadipocytes mm9 No description Adipocyte Brown ...

  18. File list: Oth.Adp.50.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.Adp.50.AllAg.Brown_preadipocytes mm9 TFs and others Adipocyte Brown preadipocyt...341028,SRX341760,SRX341767,SRX341763,SRX341027 ...

  19. File list: DNS.Adp.50.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available DNS.Adp.50.AllAg.Brown_preadipocytes mm9 DNase-seq Adipocyte Brown preadipocytes ...

  20. File list: NoD.Adp.05.AllAg.Brown_preadipocytes [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available NoD.Adp.05.AllAg.Brown_preadipocytes mm9 No description Adipocyte Brown ...

  1. Justice Deferred A Half Century After Brown v. Board of Education (United States)

    Pettigrew, Thomas F.


    The road to Brown v. Board of Education (1954) was a slow and circuitous climb, whereas the retreat down from Brown has been swift and direct. This article reviews 4 distinct U.S. Supreme Court eras of racial decisions: the segregation, preparatory, desegregation, and resegregation eras. It notes both the strengths and weaknesses of Brown and…

  2. The Scientific Attack on Brown v. Board of Education, 1954-1964 (United States)

    Jackson, John P.


    Psychologists' work was cited in the Supreme Court case of Brown v. Board of Education (1954). One criticism of the citation was that psychology could be used to overturn the Brown decision and return the country to segregation. A historical examination of such an attempt to overturn Brown in the early 1960s on the basis of new psychological…

  3. Order of Argument in the Case Brown v. Board of Education (United States)

    Chism, Kahlil; Potter, Lee Ann


    The Supreme Court's opinion in the 1954 Brown v. Board of Education case legally ended decades of racial segregation in America's public schools. Originally named after Oliver Brown, the first of many plaintiffs listed in the lower court case of Brown v. Board of Education of Topeka, KS, the landmark decision actually resolved five separate…

  4. Inhibition of Enzymatic Browning of Chlorogenic Acid by Sulfur-Containing Compounds

    NARCIS (Netherlands)

    Kuijpers, T.F.M.; Narvaez Cuenca, C.E.; Vincken, J.P.; Verloop, J.W.; Berkel, van W.J.H.; Gruppen, H.


    The antibrowning activity of sodium hydrogen sulfite (NaHSO3) was compared to that of other sulfur-containing compounds. Inhibition of enzymatic browning was investigated using a model browning system consisting of mushroom tyrosinase and chlorogenic acid (5-CQA). Development of brown color

  5. Enzymatic oxalic acid regulation correlated with wood degradation in four brown-rot fungi (United States)

    Anne Christine Steenkjær Hastrup; Frederick Green III; Patricia K. Lebow; Bo Jensen


    Oxalic acid is a key component in the initiation of brown-rot decay and it has been suggested that it plays multiple roles during the degradation process. Oxalic acid is accumulated to varying degrees among brown-rot fungi; however, details on active regulation are scarce. The accumulation of oxalic acid was measured in this study from wood degraded by the four brown-...

  6. Database for content of mercury in Polish brown coal (United States)

    Jastrząb, Krzysztof


    Poland is rated among the countries with largest level of mercury emission in Europe. According to information provided by the National Centre for Balancing and Management of Emissions (KOBiZE) more than 10.5 tons of mercury and its compounds were emitted into the atmosphere in 2015 from the area of Poland. Within the scope of the BazaHg project lasting from 2014 to 2015 and co-financed from the National Centre of Research and Development (NCBiR) a database was set up with specification of mercury content in Polish hard steam coal, coking coal and brown coal (lignite) grades. With regard to domestic brown coal the database comprises information on coal grades from Brown Coal Mines of `Bełchatów', `Adamów', `Turów' and `Sieniawa'. Currently the database contains 130 records with parameters of brown coal, where each record stands for technical analysis (content of moisture, ash and volatile particles), elemental analysis (CHNS), content of chlorine and mercury as well as net calorific value and combustion heat. Content of mercury in samples of brown coal grades under test ranged from 44 to 985 μg of Hg/kg with the average level of 345 μg of Hg/kg. The established database makes up a reliable and trustworthy source of information about content of mercury in Polish fossils. The foregoing details completed with information about consumption of coal by individual electric power stations and multiplied by appropriate emission coefficients may serve as the background to establish loads of mercury emitted into atmosphere from individual stations and by the entire sector of power engineering in total. It will also enable Polish central organizations and individual business entities to implement reasonable policy with respect of mercury emission into atmosphere.

  7. NTT Observations Indicate that Brown Dwarfs Form Like Stars (United States)


    Dusty Disks Detected around Very Young Substellar Objects in the Orion Nebula Summary An international team of astronomers [2] is announcing today the discovery of dusty disks surrounding numerous very faint objects that are believed to be recently formed Brown Dwarfs in the Orion Nebula [3]. This finding is based on detailed observations with SOFI, a specialised infrared-sensitive instrument at the ESO 3.5-m New Technology Telescope at the La Silla Observatory. It is of special interest because it sheds light on the origin and nature of substellar objects, known as "Brown Dwarfs" . In particular, these results suggest that Brown Dwarfs share a common origin with stars and that Brown Dwarfs are more similar in nature to stars than to planets and, like stars, have the potential to form with accompanying systems of planets. Moreover, the presence of dusty protoplanetary disks around the faintest objects in the Orion Nebula cluster confirms both the membership of these faint stars in the cluster and their nature as bona-fide substellar objects, making this the largest population of Brown Dwarf objects yet known . These important results are being reported today to the American Astronomical Society Meeting in Pasadena (California, USA). PR Photo 22a/01 : Infrared picture of the Orion Nebula (NTT + SOFI). PR Photo 22b/01 : "Finding Chart" for Very Young Brown Dwarfs in the Orion Nebula. PR Photo 22c/01 : Animated GIF presentation of PR Photos 22a+b/01. Faint substellar objects in the Milky Way Over the past 5 years, several groups of astronomers have identified a type of very faint, substellar objects within our Milky Way galaxy. These gaseous objects have very low masses and will never shine like normal stars because they cannot achieve central temperatures high enough for sustained thermal nuclear reactions to occur in their cores. Such objects weigh less than about 7% of our Sun and have been variously called "Brown Dwarfs" , "Failed Stars" or "Super Planets

  8. Relationship between the enzymatic browning and phenylalanine ammonia-lyase activity of cut lettuce, and the prevention of browning by inhibitors of polyphenol biosynthesis. (United States)

    Hisaminato, H; Murata, M; Homma, S


    Cut lettuce stored at 4 degrees C gradually turned brown on the cut section after several days of storage. Three factors for enzymatic browning, the polyphenol content, polyphenol oxidase activity, and phenylalanine ammonia-lyase (PAL) activity, were examined during the cold storage of cut lettuce. A relationship between the browning and PAL activity was apparent. We tried to prevent this browning by using the two enzyme inhibitors, 2-aminoindane-2-phosphonic acid (AIP), an inhibitor of the phenylpropanoid pathway, and glyphosate, an inhibitor of the shikimate pathway. AIP and glyphosate significantly inhibited the browning of cut lettuce. The polyphenol content and PAL activity were both reduced by the treatment with AIP. These results show that regulating the biosynthesis of polyphenols is essential to prevent the browning of cut lettuce.

  9. Exposure of Brown Recluse and Brown Widow Spiders (Araneae: Sicariidae, Theridiidae) to a Commercial Sulfuryl Fluoride Fumigation. (United States)

    Vetter, Richard S; Hoddle, Mark S; Choe, Dong-Hwan; Thoms, Ellen


    The body of pesticide research on spiders is sparse with most studies using topical or residual applications to assess efficacy. Data on the effects of fumigation on spider survivorship are scarce in the scientific literature. In this study, we exposed adult male and female brown recluse spiders, Loxosceles reclusa Gertsch & Mulaik, and female brown widow spiders, Latrodectus geometricus C. L. Koch, to a commercial fumigation event using sulfuryl fluoride directed at termite control. General consensus from the pest control industry is that fumigation is not always effective for control of spiders for a variety of reasons, including insufficient fumigant dosage, particularly, for contents of egg sacs that require a higher fumigant dosage for control. We demonstrated that a sulfuryl fluoride fumigation with an accumulated dosage of 162 oz-h per 1,000 ft(3) at 21°C over 25 h (≈1.7 × the drywood termite dosage) directed at termites was sufficient to kill adult brown recluse and brown widow spiders. The effectiveness of commercial fumigation practices to control spiders, and particularly their egg sacs, warrants further study. © 2014 Entomological Society of America.

  10. The role of various amino acids in enzymatic browning process in potato tubers, and identifying the browning products. (United States)

    Ali, Hussein M; El-Gizawy, Ahmed M; El-Bassiouny, Rawia E I; Saleh, Mahmoud A


    The effects of five structurally variant amino acids, glycine, valine, methionine, phenylalanine and cysteine were examined as inhibitors and/or stimulators of fresh-cut potato browning. The first four amino acids showed conflict effects; high concentrations (⩾ 100mM for glycine and ⩾ 1.0M for the other three amino acids) induced potato browning while lower concentrations reduced the browning process. Alternatively, increasing cysteine concentration consistently reduced the browning process due to reaction with quinone to give colorless adduct. In PPO assay, high concentrations (⩾ 1.11 mM) of the four amino acids developed more color than that of control samples. Visible spectra indicated a continuous condensation of quinone and glycine to give colored adducts absorbed at 610-630 nm which were separated and identified by LC-ESI-MS as catechol-diglycine adduct that undergoes polymerization with other glycine molecules to form peptide side chains. In lower concentrations, the less concentration the less developed color was observed. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice. (United States)

    Ng, Raymond; Hussain, Nurul Attiqah; Zhang, Qiongyi; Chang, Chengwei; Li, Hongyu; Fu, Yanyun; Cao, Lei; Han, Weiping; Stunkel, Walter; Xu, Feng


    Brown adipose tissue (BAT) activation and subcutaneous white fat browning are essential components of the thermogenic response to cold stimulus in mammals. microRNAs have been shown to regulate both processes in cis. Here, we identify miR-32 as a BAT-specific super-enhancer-associated miRNA in mice that is selectively expressed in BAT and further upregulated during cold exposure. Inhibiting miR-32 in vivo led to impaired cold tolerance, decreased BAT thermogenesis, and compromised white fat browning as a result of reduced serum FGF21 levels. Further examination showed that miR-32 directly represses its target gene Tob1, thereby activating p38 MAP kinase signaling to drive FGF21 expression and secretion from BAT. BAT-specific miR-32 overexpression led to increased BAT thermogenesis and serum FGF21 levels, which further promotes white fat browning in trans. Our results suggested miR-32 and Tob1 as modulators of FGF21 signaling that can be manipulated for therapeutic benefit against obesity and metabolic syndrome. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  12. Prevention of enzymatic browning of yacon flour by the combined use of anti-browning agents and the study of its chemical composition


    Oscar Romero Lopes Rodrigues; Eduardo Ramirez Asquieri; Daniela Castilho Orsi


    Yacon roots present functional properties because of the high levels of fructooligosaccharides (FOS), which are considered as prebiotic fibers. In addition, yacon roots are rich in phenolic compounds. During the processing of yacon, the freshly cut surface undergoes rapid enzymatic browning. Control of enzymatic browning during processing is very important to preserve the appearance of yacon flour. In this study, it was evaluated the combined effect of anti-browning agents (ascorbic acid, cit...

  13. [Multiple brown tumors in a female hemodialyzed patient with severe secondary hyperparathyroidism]. (United States)

    Peces, R; Gil, F; González, F; Ablanedo, P


    Skeletal brown tumours are relatively uncommon, and brown tumours that involve multiple bones are considered very rare. We describe a 29-year-old woman with chronic renal failure (CRF) who had undergone hemodialysis for 21 years and developed multiple brown tumours associated with severe secondary hyperparathyroidism. Computed tomography (CT) revealed multiple brown tumours involving scapula, ribs, spine and sacroiliac bone. Microscopic analysis of the brown tumour showed dense infiltration of the marrow space by reactive fibroblastic tissue with irregularly distributed multinucleated osteoclastic giants cells and marked increase in hematopoietic elements.

  14. Glutathione suppresses the enzymatic and non-enzymatic browning in grape juice. (United States)

    Wu, Shengjun


    Browning tends to occur in grape juice during processing and storage and decreases the commercial value of it. Thus, browning inhibition is an important objective for manufacturers. This study aims to investigate the efficacy of glutathione as a browning inhibitor for use on grape juice. Grape juice browning treated with glutathione was monitored during processing and accelerated browning. 0.04% of glutathione inhibited 99.4% of the polyphenoloxidase activity in the grape juice. Consequently, during processing at room temperature and accelerated browning at 80 °C, the browning in the grape juice treated with glutathione was significantly lower than that in the control (pbrowning inhibitor used in grape juice. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Anthraquinones isolated from the browned Chinese chestnut kernels (Castanea mollissima blume) (United States)

    Zhang, Y. L.; Qi, J. H.; Qin, L.; Wang, F.; Pang, M. X.


    Anthraquinones (AQS) represent a group of secondary metallic products in plants. AQS are often naturally occurring in plants and microorganisms. In a previous study, we found that AQS were produced by enzymatic browning reaction in Chinese chestnut kernels. To find out whether non-enzymatic browning reaction in the kernels could produce AQS too, AQS were extracted from three groups of chestnut kernels: fresh kernels, non-enzymatic browned kernels, and browned kernels, and the contents of AQS were determined. High performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) methods were used to identify two compounds of AQS, rehein(1) and emodin(2). AQS were barely exists in the fresh kernels, while both browned kernel groups sample contained a high amount of AQS. Thus, we comfirmed that AQS could be produced during both enzymatic and non-enzymatic browning process. Rhein and emodin were the main components of AQS in the browned kernels.

  16. Low accumulation of chlorogenic acids represses reddening during flesh browning in Japanese peach "Okayama PEH7". (United States)

    Yokotani, Naoki; Uraji, Misugi; Hara, Miyuki; Hihara, Seisuke; Hatanaka, Tadashi; Oda, Kenji


    In peaches, fruit flesh browns unattractively after peeling or cutting. A recently developed cultivar, Okayama PEH7, was distinct from other Japanese cultivars, including Okayama PEH8, with respect to its reduced browning potential. Homogenate prepared from Okayama PEH7 flesh had significantly less reddening during the browning reaction. Okayama PEH7 had less soluble phenolic compounds and higher polyphenol oxidase activity than Okayama PEH8. Reduced browning was observed even when phenols prepared from Okayama PEH7 were incubated with crude extract from Okayama PEH8, suggesting that phenols lower the browning potential of Okayama PEH7. In Okayama PEH7, contents of chlorogenic acid and its isomers were about one-tenth compared to Okayama PEH8. Exogenous addition of chlorogenic acid to Okayama PEH7 homogenate increased the browning potential and visibly enhanced reddening. These results indicate that the reduced browning of Okayama PEH7 flesh is due to a defect in chlorogenic acid accumulation.

  17. Brown queer compositionistas and the reflective practice of automythnography. (United States)

    Inayatulla, Shereen


    Autoethnographic self-reflection is a strategy for teachers to examine their pedagogies and academic workspaces at large. In the process of moving from teaching composition at an institution in the Midwest to one in Southeast Queens, this author describes significant shifts in how she perceived herself as a Brown queer pedagogue. In order to analyze these shifts in ways that advance her pedagogical praxis, the author evaluates the research tools available to her and offers a hybrid method for reflection, which she calls "vulnerable automythnography." Applying this reflective practice to a specific classroom occurrence, the author considers some ways in which vulnerable automythnography offers underrepresented teachers and students an opportunity to examine the aggressions Black, Brown, and queer bodies face in academic settings. She posits this method of reflection as a tool for savvy resistance and intervention.

  18. Oxidative stress and partial migration in brown trout (Salmo trutta)

    DEFF Research Database (Denmark)

    Birnie-Gauvin, Kim; Peiman, K. S.; Larsen, Martin Hage


    During migration, animals are typically limited by their endogenous energetic resources which must be allocated to the physiological costs associated with locomotion, as well as avoiding and/or compensating for oxidative stress. To date, there have been few attempts to understand the role...... oxidative stress and migration. Using the brown trout, we obtained blood samples from juveniles from a coastal stream in Denmark in the fall prior to peak seaward migration which occurs in the spring, and assayed for antioxidant capacity (oxygen radical absorbance capacity) and oxidative stress levels...... of oxidative status in migration biology, particularly in fish. Semi-anadromous brown trout (Salmo trutta, Linnaeus 1758) exhibit partial migration, where some individuals smoltify and migrate to sea, and others become stream residents, providing us with an excellent model to investigate the link between...

  19. MicroRNA networks regulate development of brown adipocytes. (United States)

    Trajkovski, Mirko; Lodish, Harvey


    Brown adipose tissue (BAT) is specialized for heat generation and energy expenditure as a defense against cold and obesity; in both humans and mice increased amounts of BAT are associated with a lean phenotype and resistance to development of the metabolic syndrome and its complications. Here we summarize recent research showing that several BAT-expressed microRNAs (miRNAs) play important roles in regulating differentiation and metabolism of brown and beige adipocytes; we discuss the key mRNA targets downregulated by these miRNAs and show how these miRNAs affect directly or indirectly transcription factors important for BAT development. We suggest that these miRNAs could be part of novel therapeutics to increase BAT in humans. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Cervical disc herniation manifesting as a Brown-Sequard syndrome

    Directory of Open Access Journals (Sweden)

    Kunio Yokoyama


    Full Text Available Brown-Sequard syndrome is commonly seen in the setting of spinal trauma or an extramedullary spinal neoplasm. The clinical picture reflects hemisection of the spinal cord. We report a rare case of Brown-Sequard syndrome caused by a large cervical herniated disc. A 63-year-old man presented with progressive right hemiparesis and disruption of pain and temperature sensation on the left side of the body. Magnetic resonance imaging showed large C3-C4 disc herniation compressing the spinal cord at that level, with severe canal stenosis from C4 through C7. Decompressive cervical laminoplasty was performed. After surgery, complete sensory function was restored and a marked improvement in motor power was obtained.

  1. Surface gravity analysis of the NIRSPEC Brown Dwarf Spectroscopic Survey (United States)

    Martin, Emily; McLean, Ian S.; Mace, Gregory N.; Logsdon, Sarah E.; Rice, Emily L.


    We present an analysis of J band spectra for over two hundred M, L, and T dwarfs obtained from the Brown Dwarf Spectroscopic Survey (BDSS) using NIRSPEC on the Keck II Telescope. This R~2000 sample includes spectra presented in McLean et al. (2003), as well as many new, unpublished spectra observed for the BDSS, more than doubling the size of the original survey. We determine surface gravity-sensitive spectral indices from the literature, which probe K I and FeH absorption, and we estimate uncertainties using a Monte Carlo iterative method. With these indices we characterize surface gravities of our targets in order to disentangle temperature and age of brown dwarfs and low mass stars of various masses.

  2. Multiple brown tumors of the jaws in primary hyperparathyroidism

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyoung A; Koh, Kwang Joon [School of Dentisity, Chonbuk National University, Jeonju (Korea, Republic of)


    Brown tumor is usually diagnosed at the terminal stage of hyperparathyroidism. Diagnosis of this tumor is confirmed by endocrinologic investigations along with clinical and radiographic examination. Radiographical differential diagnosis of this tumor includes central giant cell granuloma, aneurysmal bone cyst, metastatic tumor, multiple myeloma, and Paget disease. This report presents a rare case of multiple brown tumors occurring at the maxilla and mandible, which was initially misdiagnosed as central giant cell granuloma. Plain radiographs demonstrated multiple well-defined multilocular radiolucency. CT images showed soft tissue mass with low attenuated lesions, perforation of the lingual cortical plate, and a heterogeneous mass at the right thyroid lobe. These findings were consistent with parathyroid adenoma. The patient had hypercalcemia, hypophosphatemia, and elevated alkaline phosphatase level. Surgical excision of the tumor was performed. No recurrence was observed during a 28-month follow-up.

  3. Crafting identities and accessing opportunities post-Brown. (United States)

    Spencer, Margaret Beale


    Decades following Brown v. Board of Education (1954), issues regarding the effects of skin color, poverty, and racial differences in the availability of protective factors persist. For a multiethnic sample of mainly African American (56%), female (69%), and high-achieving (65%) youths, a dual-axis model of vulnerability is used to compare four groups of youths identified as high, masked, low, and undetermined vulnerability on the basis of the presence of risk and protective factors. Risks included level of poverty, number of parents in home, and skin-color pigmentation. Protective factors included youths' perceptions of school climate, parental monitoring, and consonance between skin pigmentation and preferred skin color. The author suggests that 50 years post-Brown, issues concerning White privilege, color stereotyping, power discrepancies, and economic disparities maintain "invisible" and persistent hurdles for vulnerable youths who vary on available protective factors. Findings confirm the impact of vulnerability on psychosocial and achievement outcomes. Copyright (c) 2005 APA, all rights reserved.

  4. Brown recluse spider envenomation: dermatologic application of hyperbaric oxygen therapy. (United States)

    Tutrone, William D; Green, Kimberly M; Norris, Tom; Weinberg, Jeffrey M; Clarke, Dick


    Envenomation from the brown recluse (Loxosceles recluse) spider commonly proceed on one of three clinical pathways. The majority of bites (90%) result in nothing more than a local reaction. They are essentially self-limiting, require little if any attention, and resolve spontaneously. A great majority of the remaining bites will produce necrotic ulcerations of various sizes and dimensions, with systemic sequela ranging from fever to hemolysis and kidney failure. Finally, and in the most rare cases, the patient will succumb a fatal systemic reaction. Current therapeutic options for these wounds remain controversial and include the following: local care, corticosteroids, dapsone, and hyperbaric oxygen (HBO) therapy. This article will review the application of HBO therapy for patients who are envenomated by brown recluse spiders. Information for this manuscript was derived from multiple MEDLINE searches as well as searches of the National Baromedical Service's hyperbaric specialty literature collection.

  5. Electrocatalytic oxidation of brown coal from the Adamow mine

    Energy Technology Data Exchange (ETDEWEB)

    Studnicki, M. (Zaklad Karbochemii PAN, Gliwice (Poland))


    Studies the possibility of electrocatalytic oxidation of brown coal and products obtained therefrom. Two cycles of experiments were performed with either external or internal power supply. The results were compared to electrocatalytic oxidation of n-hexane in a fuel cell. Reaction products were subject to extraction in methylene chloride and analyzed with the use of high resolution NMR spectroscopy. Conditions for tests and for analyses are described. Two figures and six tables are provided. It was found that alternating electrocatalytic reduction and oxidation of the Adamow brown coal yields aliphatic carboxylic acids C20-C33. Electrocatalytic oxidation of n-hexane yields alcohols C1-C3. The tested method was found capable of producing oxygen-containing compounds and electricity without carbon dioxide release. 2 refs.


    Energy Technology Data Exchange (ETDEWEB)

    Skemer, Andrew J.; Morley, Caroline V.; Fortney, Jonathan J. [University of California, Santa Cruz, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Allers, Katelyn N. [Bucknell University, 701 Moore Avenue, Lewisburg, PA 17837 (United States); Geballe, Thomas R. [Gemini Observatory, 670 North A’ohoku Place, Hilo, HI 96720 (United States); Marley, Mark S.; Lupu, Roxana [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Faherty, Jacqueline K. [Carnegie Institute for Science, Department of Terrestrial Magnetism, 5241 Broad Branch Road, NW, Washington, DC 20015 (United States); Bjoraker, Gordon L. [NASA Goddard Space Flight Center, 8800 Greenbelt Road, Greenbelt, MD 20771 (United States)


    The recently discovered brown dwarf WISE 0855 presents the first opportunity to directly study an object outside the solar system that is nearly as cold as our own gas giant planets. However, the traditional methodology for characterizing brown dwarfs—near-infrared spectroscopy—is not currently feasible, as WISE 0855 is too cold and faint. To characterize this frozen extrasolar world we obtained a 4.5–5.2 μ m spectrum, the same bandpass long used to study Jupiter’s deep thermal emission. Our spectrum reveals the presence of atmospheric water vapor and clouds, with an absorption profile that is strikingly similar to Jupiter’s. The spectrum quality is high enough to allow for the investigation of dynamical and chemical processes that have long been studied in Jupiter’s atmosphere, but now on an extrasolar world.

  7. Primary hyperparathyroidism having multiple Brown tumors mimicking malignancy

    Directory of Open Access Journals (Sweden)

    Ekram Ullah


    Full Text Available Primary hyperparathyroidism is a disease characterized by excessive secretion of parathormone. During the course of this disease, bone loss occurs, particularly depending on resorption of the skeletal system. One of the complications of primary hyperparathyroidism is fibrotic, cystic bony changes which is called Brown tumor. Skeletal manifestations in the form of Brown tumors are rare and according to literature occur in less than 2% of patients suffering from any form of hyperparathyroidism. Such rare and multiple benign lesions may simulate a malignant neoplasm and pose a real challenge for the clinician in its differential diagnosis. We present a case of a 23-year-old Indian woman who was evaluated for multiple lytic expansile lesions with a strong suspicion of malignancy and fibrous dysplasia but turned out to be a case of primary hyperparathyroidism.

  8. A brown dwarf orbiting an M-dwarf

    DEFF Research Database (Denmark)

    Bachelet, E.; Fouqué, P.; Albrow, M.D.


    Context. Caustic crossing is the clearest signature of binary lenses in microlensing. In the present context, this signature is diluted by the large source star but a detailed analysis has allowed the companion signal to be extracted. Aims. MOA 2009-BLG-411 was detected on August 5, 2009 by the M....... Conclusions. As far as we are aware, this is the first detection using the microlensing technique of a binary system in our Galaxy composed of an M-star and a brown dwarf....... gives two local minima, which correspond to the theoretical degeneracy s ≡ s-1. We find that the lens is composed of a brown dwarf secondary of mass MS = 0.05 M⊙ orbiting a primary M-star of mass MP = 0.18 M⊙. We also reveal a new mass-ratio degeneracy for the central caustics of close binaries...

  9. Orexin receptor-1 mediates brown fat developmental differentiation (United States)

    Sellayah, Dyan; Sikder, Devanjan


    Orexin A (OX) is a small excitatory neuropeptide hormone that stimulates feeding, wakefulness and energy expenditure via a pair of G-coupled protein receptors, namely orexin receptor-1 (OXR1) and orexin receptor-2 (OXR2). OX-deficient mice are sensitive to obesity despite being hypophagic. The obesogenic effect of OX-deletion is due to brown adipose tissue (BAT) dysfunction, a defect that originates during fetal growth. Brown preadipocytes in OX-null mice display undifferentiated histological appearance and fail to support both diet- and cold-induced thermogenesis. We show that the OXR1-null mice phenocopies the differentiation defect observed in the ligand-null mice indicating that OXR1 relays OX’s differentiation and thermogenic function. Consistent with this, OX fails to induce differentiation in cultured OXR1-null preadipocytes. Thus, OX signaling via OXR1 constitutes an important thermoregulatory mechanism that defends against cold and obesity. PMID:23700511

  10. A role of active brown adipose tissue in cancer cachexia?

    Directory of Open Access Journals (Sweden)

    Emiel Beijer


    Full Text Available Until a few years ago, adult humans were not thought to have brown adipose tissue (BAT. Now, this is a rapidly evolving field of research with perspectives in metabolic syndromes such as obesity and new therapies targeting its bio-energetic pathways. White, brown and socalled brite adipose fat seem to be able to trans-differentiate into each other, emphasizing the dynamic nature of fat tissue for metabolism. Human and animal data in cancer cachexia to date provide some evidence for BAT activation, but its quantitative impact on energy expenditure and weight loss is controversial. Prospective clinical studies can address the potential role of BAT in cancer cachexia using 18F-fluorodeoxyglucose positron emission tomography-computed tomography scanning, with careful consideration of co-factors such as diet, exposure to the cold, physical activity and body mass index, that all seem to act on BAT recruitment and activity.

  11. Brown recluse spider (Loxosceles reclusa) envenomation in small animals. (United States)

    Pace, Lonny B; Vetter, Richard S


    To provide a comprehensive review of relevant literature regarding the brown recluse spider (BRS) and to define those criteria that must be satisfied before making a diagnosis of brown recluse envenomation. The complex venom of the BRS contains sphingomyelinase D, which is capable of producing all the clinical signs in the human and some animal models. There is no current commercially available test. In humans there are many proposed guidelines to achieve a definitive diagnosis; however, there are no established guidelines for veterinary patients. Currently, no consensus exists for treatment of BRS envenomation other than supportive care, which includes rest, thorough cleaning of the site, ice, compression, and elevation. Prognosis varies based on severity of clinical signs and response to supportive care. © Veterinary Emergency and Critical Care Society 2009.

  12. Ulcerative fungal keratitis in a Brown Swiss cow


    Voelter-Ratson, K; Monod, M; Braun, Ueli; Spiess, Bernhard M


    An 11-year-old Swiss Brown cow was referred to the Food Animal Department of the Veterinary Teaching Hospital in Zurich, Switzerland due to lateral recumbency of unknown origin. The animal had developed enophthalmos due to dehydration at the time of presentation. Two days after hospitalization, the cow showed blepharospasm and epiphora of the right eye and the Ophthalmology Service was consulted. Ophthalmic examination of the right eye revealed a fluorescein positive, paraxial, corneal superf...

  13. Brown Adipose Tissue Has Sympathetic-Sensory Feedback Circuits


    Ryu, Vitaly; Garretson, John T.; Liu, Yang; Vaughan, Cheryl H.; Bartness, Timothy J.


    Brown adipose tissue (BAT) is an important source of thermogenesis which is nearly exclusively dependent on its sympathetic nervous system (SNS) innervation. We previously demonstrated the SNS outflow from brain to BAT using the retrograde SNS-specific transneuronal viral tract tracer, pseudorabies virus (PRV152) and demonstrated the sensory system (SS) inflow from BAT to brain using the anterograde SS-specific transneuronal viral tract tracer, H129 strain of herpes simplex virus-1. Several b...

  14. Hanbury-Brown and Twiss interference of anyons


    Campagnano, Gabriele; Zilberberg, Oded; Gornyi, Igor V.; Feldman, Dmitri E.; Potter, Andrew C.; Gefen, Yuval


    We present a study of an Hanbury Brown and Twiss (HBT) interferometer realized with anyons. Such a device can directly probe entanglement and fractional statistics of initially uncorrelated particles. We calculate HBT cross-correlations of Abelian Laughlin anyons. The correlations we calculate exhibit partial bunching similar to bosons, indicating a substantial statistical transmuta- tion from the underlying electronic degrees of freedom. We also find qualitative differences between the anyon...

  15. Brown tumor of the hard palate in secondary hyperparathyroidism.

    Directory of Open Access Journals (Sweden)

    Shah B


    Full Text Available Jaw bones are rarely involved in secondary hyperparathyroidism. We report a case of 13 year old girl who presented with progressive chronic renal failure and secondary hyperparathyroidism. Five months after beginning of hemodialysis, a large brown tumor developed on the hard palate, extending to the maxilla causing difficulty in swallowing and breathing. She died of massive intestinal hemorrhage five months after excision of the mass.

  16. "Brown v. Board of Education": A South African Perspective (United States)

    Alexander, Neville


    Although this author knew very little about the details of "Brown v. Board of Education" as a legal matter when he read about it as a young second-year student at the University of Cape Town in 1954, the Court's verdict had a direct influence on his political perspectives and on his aspirations as a would-be teacher for the rest of his…

  17. Browning reaction systems as sources of mutagens and antimutagens.


    Powrie, W D; Wu, C.H.; Molund, V P


    Heated food systems contain hundreds of chemical compounds, some being mutagenic and others being antimutagenic. Studies have indicated that foods exposed to drying, frying, roasting, baking, and broiling conditions possess net mutagenic activity as assessed by the Ames/Salmonella/microsome mutagenicity test and the chromosome aberration assay with Chinese hamster ovary (CHO) cells. With the above-mentioned heat treatment of food, nonenzymic browning reactions are generally proceeding at rapi...

  18. Trap Design for the Brown Recluse Spider, Loxosceles reclusa


    Parks, Jennifer; Stoecker, William V.; Paige, Robert L.


    While there are limited options for chemical-free Arachnid pest control, glue-traps are one suitable alternative to pesticides. The effectiveness of several three-dimensional glue-trap shapes for trapping the brown recluse spider, Loxosceles reclusa Gertsch and Mulaik (Araneae: Sicariidae), was investigated using four novel glue-trap shape designs, which were compared to an existing design currently on the market. These four novel and one standard shape designs were tested using pairwise comp...

  19. Blast furnace coke substitutes from Victorian brown coal


    Mollah, Mamun


    Iron is usually produced from its ores using coke in a blast furnace (BF). Coke, a hard and macroporous carbon material, is produced from special coals (coking coals) and acts as fuel, smelting agent, and the permeable support for the charge to the BF. No material can completely replace coke in a BF. Coking coals are becoming harder (and more expensive) to obtain. Victorian brown coal (VBC) is accessible, cheap, with low mineral concentrations, which is favourable for iron production in a BF....

  20. Regulation of brown adipocyte metabolism by myostatin/follistatin signaling


    Rajan eSingh; Melissa eBraga; Shehla ePervin


    Obesity develops from perturbations of cellular bioenergetics, when energy uptake exceeds energy expenditure, and represents a major risk factor for the development of type 2 diabetes, dyslipidemia, cardiovascular disease, cancer, and other conditions. Brown adipose tissue (BAT) has long been known to dissipate energy as heat and contribute to energy expenditure, but its presence and physiological role in adult human physiology has been questioned for years. Recent demonstrations of metabolic...

  1. [MRI in congenital Brown's syndrome: report of 16 cases]. (United States)

    Cousin, M; Girard, N; Denis, D


    Superior oblique retraction syndrome or Brown's syndrome is one of the so-called restrictive syndromes causing anatomic strabismus. It is characterized by active and passive limitation of upward gaze in adduction in the field of action of the superior oblique muscle (SO). The etiology of this congenital syndrome remains unknown. The purpose of this prospective study is to analyze brain and orbital magnetic resonance imaging (MRI) in patients with congenital Brown's syndrome. Sixteen children (19 months - 9 years) underwent complete ophthalmologic evaluation followed by brain/orbital MRI with attention to the superior oblique muscle. Average age at time of MRI was 4.2 years old. Among patients included were eight girls and eight boys. MRI was performed on a 1.5T (Symphony TIM, Siemens, Erlangen) to visualize the orbit and specifically the SO. Of 16 eyes, 13 demonstrated radiologic abnormalities of the SO muscle; six demonstrated tendon-trochlea complex hypertrophy, four demonstrated complete SO hypertrophy (tendon-trochlea-muscle belly), one demonstrated trochlear hypertrophy, and two demonstrated abnormalities solely of the tendons, of which one was longer and one was thinner with fibrosis. MRI shows a high frequency of SO radiologic abnormalities in congenital Brown's syndrome. MRI permits the analysis of not only the tendon, but also the trochlea and muscle belly, whereas surgery only allows visualization of the tendon. MRI proved to be an interesting tool for investigation of these patients and for a better understanding of the pathogenesis. Copyright © 2012. Published by Elsevier Masson SAS.

  2. Recent Results of the NIRSPEC Brown Dwarf Spectroscopic Survey (United States)

    Rice, Emily L.; McLean, I. S.; Prato, L.; McGovern, M. R.; Burgasser, A. J.; Kirkpatrick, J.; Kim, S. S.


    The NIRSPEC Brown Dwarf Spectroscopic Survey (BDSS) began in 1999 with the commissioning of NIRSPEC on Keck II. In the first phase of the survey, J-band spectra of 53 objects covering all spectral types from M6 to T8 were obtained at a resolving power of R 2000 (McLean et al. 2003). This poster presents results from the second phase of the survey, which focused on high-resolution (R 20,000) J-band observations for a sample of 16 very low mass stars and brown dwarfs from M2.5 to T6 (McLean et al. 2006, submitted). By comparing opacity plots and line lists to the high-resolution spectra we identify hundreds of FeH, H2O, and atomic features and analyze how these features change with spectral type. We also begin to explore the apparently complex dependence of spectral features on the metallicity and surface gravity of brown dwarf atmospheres, which is the topic of the current phase of the BDSS. Data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation.

  3. Browning reaction systems as sources of mutagens and antimutagens. (United States)

    Powrie, W D; Wu, C H; Molund, V P


    Heated food systems contain hundreds of chemical compounds, some being mutagenic and others being antimutagenic. Studies have indicated that foods exposed to drying, frying, roasting, baking, and broiling conditions possess net mutagenic activity as assessed by the Ames/Salmonella/microsome mutagenicity test and the chromosome aberration assay with Chinese hamster ovary (CHO) cells. With the above-mentioned heat treatment of food, nonenzymic browning reactions are generally proceeding at rapid rates and are involved in the development of mutagens. Caramelization and Maillard reactions are two important pathways in the nonenzymic browning of food and are responsible for the formation of volatile aromatic compounds, intermediate nonvolatile compounds, and brown pigments called melanoidins. Heated sugar-amino acid mixtures possessed mutagenic activities which have been assessed by short-term bioassays. Purified Maillard and caramelization reaction products such as reductones, dicarbonyls, pyrazines, and furan derivatives have exhibited mutagenicity and clastogenicity. The water-insoluble fraction (WIF) of instant coffee and a model-system melanoidin (MSM) have been shown to inhibit the mutagenicity of known carcinogens--aflatoxin B1 (AFB1), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and benzo(a)pyrene (BP)--in aqueous dispersion. WIF and MSM were found to be effective binding agents for the carcinogens.

  4. Management of brown recluse spider bites in primary care. (United States)

    Mold, James W; Thompson, David M


    Treatment of brown recluse spider bites remains controversial; there are multiple options but little evidence of their effectiveness. Over a 5-year period, family physicians enrolled consecutive patients with suspected brown recluse spider bites. Usual care was provided based on physician preferences. Topical nitroglycerine patches and vitamin C tablets were provided at no cost for those who wished to use them. Baseline data were collected, and patients were followed-up weekly until healing occurred. Outcome measures included time to healing and occurrence of scarring. Regression methods were used to evaluate the impact of the 4 main treatment approaches (corticosteroids, dapsone, topical nitroglycerine, and high-dose vitamin C) after controlling for bite severity and other predictors. Two hundred and sixty-two patients were enrolled; outcomes were available for 189. The median healing time was 17 days. Only 21% had permanent scarring. One hundred seventy-four received a single treatment modality. Among this group, 12 different modalities were used. After controlling for other variables, predictors of more rapid healing included lower severity level, less erythema, and less necrosis at time of presentation, younger age, no diabetes, and earlier medical attention. Systemic corticosteroids and dapsone were associated with slower healing. Predictors of scarring were higher severity, presence of necrosis, and diabetes. Dapsone was associated with an increased probability of scarring. We found no evidence that commonly used treatment approaches reduced healing time or the likelihood of scarring in suspected brown recluse spider bites.

  5. Brown carbon in tar balls from smoldering biomass combustion (United States)

    Chakrabarty, R. K.; Moosmüller, H.; Chen, L.-W. A.; Lewis, K.; Arnott, W. P.; Mazzoleni, C.; Dubey, M. K.; Wold, C. E.; Hao, W. M.; Kreidenweis, S. M.


    We report the direct observation of laboratory production of spherical, carbonaceous particles - "tar balls" - from smoldering combustion of two commonly occurring dry mid-latitude fuels. Real-time measurements of spectrally varying absorption Ångström coefficients (AAC) indicate that a class of light absorbing organic carbon (OC) with wavelength dependent imaginary part of its refractive index - optically defined as "brown carbon" - is an important component of tar balls. The spectrum of the imaginary parts of their complex refractive indices can be described with a Lorentzian-like model with an effective resonance wavelength in the ultraviolet (UV) spectral region. Sensitivity calculations for aerosols containing traditional OC (no absorption at visible and UV wavelengths) and brown carbon suggest that accounting for near-UV absorption by brown carbon leads to an increase in aerosol radiative forcing efficiency and increased light absorption. Since particles from smoldering combustion account for nearly three-fourths of the total carbonaceous aerosol mass emitted globally, inclusion of the optical properties of tar balls into radiative forcing models has significance for the Earth's radiation budget, optical remote sensing, and understanding of anomalous UV absorption in the troposphere.

  6. Atmospheric brown clouds: regional assessment report with focus on Asia

    Energy Technology Data Exchange (ETDEWEB)

    Ramanathan, V.; M. Agrawal; H. Akimoto (and others)


    UNEP commissioned an assessment of the impacts of atmospheric brown clouds (ABCs) on regional radiative forcing, climate, agriculture, water and health. Part 1 of this report describes the impacts on radiative forcing and climate. The impacts of ABCs on agriculture and human health are described I Parts II and III, respectively. The study identified 13 cities as ABC hotspots, including Bangkok, Beijing, Mumbai, New Delhi, Seoul, Shanghai and Shenzhen. The effect of brown clouds is to make these cities darker or dimmer because particles such as sulfates from burning coal and other fossil fuels reflect and scatter rays back to space and other particles such as black carbon absorb sunlight before it reaches the ground. Brown clouds contain a variety of toxic aerosols, carcinogens and particles including particulate matter (PM) of less than 2.5 microns in width. These have been linked with a variety of health effects from respiratory disease and cardio-vascular problems. Increase in concentrations of PM 2.5 of 20 microgrammes per cubic metre could lead to about 340,000 excess deaths per year in China and India.

  7. Eradicant and curative treatments of hexanal against peach brown rot

    Directory of Open Access Journals (Sweden)

    Juliana Silveira Baggio


    Full Text Available Brown rot, caused by Monilinia spp. , is one of the most important peach (Prunuspersica (L. Batsch diseases and the main cause of postharvest losses. Currently, alternative methods for postharvest disease control, such as the use of volatiles, are under investigation. The objective of this study was to determine the effects of hexanal on the in vitro development of Monilinia fructicola and M. laxa and on monocyclic components of brown rot on peaches. To evaluate the effect on pathogen development in vitro, a single dose of 215 µL of liquid hexanal was placed on glass jars in closed plastic containers (4.3 L at the moment of fungi transfer, 24 or 48 h after transferring to Petri dishes. After hexanal application, the Petri dishes were kept inside the containers that were closed for 24 h at 20 ºC. Mycelial growth was measured seven days after hexanal removal. For in vivo assays, inoculated fruits were kept in closed plastic containers, and hexanal was applied at the moment of fruit inoculation or 24 hours thereafter. The monocyclic components infection frequency, expressed as brown rot incidence, lesion diameter and lesion sporulation, were assessed daily for seven days. Overall, hexanal was more effective in inhibiting mycelial growth when applied at the moment of pathogen transfer. Hexanal did not prevent pathogen infection, but reduced lesion diameter and completely inhibited spore production on the fruit for both treatments. Hexanal provides a promising alternative for chemical control and can be used in postharvest handling systems.

  8. Brown carbon in tar balls from smoldering biomass combustion

    Directory of Open Access Journals (Sweden)

    R. K. Chakrabarty


    Full Text Available We report the direct observation of laboratory production of spherical, carbonaceous particles – "tar balls" – from smoldering combustion of two commonly occurring dry mid-latitude fuels. Real-time measurements of spectrally varying absorption Ångström coefficients (AAC indicate that a class of light absorbing organic carbon (OC with wavelength dependent imaginary part of its refractive index – optically defined as "brown carbon" – is an important component of tar balls. The spectrum of the imaginary parts of their complex refractive indices can be described with a Lorentzian-like model with an effective resonance wavelength in the ultraviolet (UV spectral region. Sensitivity calculations for aerosols containing traditional OC (no absorption at visible and UV wavelengths and brown carbon suggest that accounting for near-UV absorption by brown carbon leads to an increase in aerosol radiative forcing efficiency and increased light absorption. Since particles from smoldering combustion account for nearly three-fourths of the total carbonaceous aerosol mass emitted globally, inclusion of the optical properties of tar balls into radiative forcing models has significance for the Earth's radiation budget, optical remote sensing, and understanding of anomalous UV absorption in the troposphere.

  9. PPAR{alpha} does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte

    Energy Technology Data Exchange (ETDEWEB)

    Walden, Tomas B.; Petrovic, Natasa [The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE-106 91 Stockholm (Sweden); Nedergaard, Jan, E-mail: [The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE-106 91 Stockholm (Sweden)


    Brown adipocytes and myocytes develop from a common adipomyocyte precursor. PPAR{alpha} is a nuclear receptor important for lipid and glucose metabolism. It has been suggested that in brown adipose tissue, PPAR{alpha} represses the expression of muscle-associated genes, in this way potentially acting to determine cell fate in brown adipocytes. To further understand the possible role of PPAR{alpha} in these processes, we measured expression of muscle-associated genes in brown adipose tissue and brown adipocytes from PPAR{alpha}-ablated mice, including structural genes (Mylpf, Tpm2, Myl3 and MyHC), regulatory genes (myogenin, Myf5 and MyoD) and a myomir (miR-206). However, in our hands, the expression of these genes was not influenced by the presence or absence of PPAR{alpha}, nor by the PPAR{alpha} activator Wy-14,643. Similarly, the expression of genes common for mature brown adipocyte and myocytes (Tbx15, Meox2) were not affected. However, the brown adipocyte-specific regulatory genes Zic1, Lhx8 and Prdm16 were affected by PPAR{alpha}. Thus, it would not seem that PPAR{alpha} represses muscle-associated genes, but PPAR{alpha} may still play a role in the regulation of the bifurcation of the adipomyocyte precursor into a brown adipocyte or myocyte phenotype.

  10. Top-of-atmosphere radiative forcing affected by brown carbon in the upper troposphere (United States)

    Zhang, Yuzhong; Forrister, Haviland; Liu, Jiumeng; Dibb, Jack; Anderson, Bruce; Schwarz, Joshua P.; Perring, Anne E.; Jimenez, Jose L.; Campuzano-Jost, Pedro; Wang, Yuhang; Nenes, Athanasios; Weber, Rodney J.


    Carbonaceous aerosols affect the global radiative balance by absorbing and scattering radiation, which leads to warming or cooling of the atmosphere, respectively. Black carbon is the main light-absorbing component. A portion of the organic aerosol known as brown carbon also absorbs light. The climate sensitivity to absorbing aerosols rapidly increases with altitude, but brown carbon measurements are limited in the upper troposphere. Here we present aircraft observations of vertical aerosol distributions over the continental United States in May and June 2012 to show that light-absorbing brown carbon is prevalent in the troposphere, and absorbs more short-wavelength radiation than black carbon at altitudes between 5 and 12 km. We find that brown carbon is transported to these altitudes by deep convection, and that in-cloud heterogeneous processing may produce brown carbon. Radiative transfer calculations suggest that brown carbon accounts for about 24% of combined black and brown carbon warming effect at the tropopause. Roughly two-thirds of the estimated brown carbon forcing occurs above 5 km, although most brown carbon is found below 5 km. The highest radiative absorption occurred during an event that ingested a wildfire plume. We conclude that high-altitude brown carbon from biomass burning is an unappreciated component of climate forcing.

  11. Loss of MyoD Promotes Fate Transdifferentiation of Myoblasts Into Brown Adipocytes

    Directory of Open Access Journals (Sweden)

    Chao Wang


    Full Text Available Brown adipose tissue (BAT represents a promising agent to ameliorate obesity and other metabolic disorders. However, the abundance of BAT decreases with age and BAT paucity is a common feature of obese subjects. As brown adipocytes and myoblasts share a common Myf5 lineage origin, elucidating the molecular mechanisms underlying the fate choices of brown adipocytes versus myoblasts may lead to novel approaches to expand BAT mass. Here we identify MyoD as a key negative regulator of brown adipocyte development. CRISPR/CAS9-mediated deletion of MyoD in C2C12 myoblasts facilitates their adipogenic transdifferentiation. MyoD knockout downregulates miR-133 and upregulates the miR-133 target Igf1r, leading to amplification of PI3K–Akt signaling. Accordingly, inhibition of PI3K or Akt abolishes the adipogenic gene expression of MyoD null myoblasts. Strikingly, loss of MyoD converts satellite cell-derived primary myoblasts to brown adipocytes through upregulation of Prdm16, a target of miR-133 and key determinant of brown adipocyte fate. Conversely, forced expression of MyoD in brown preadipocytes blocks brown adipogenesis and upregulates the expression of myogenic genes. Importantly, miR-133a knockout significantly blunts the inhibitory effect of MyoD on brown adipogenesis. Our results establish MyoD as a negative regulator of brown adipocyte development by upregulating miR-133 to suppress Akt signaling and Prdm16.

  12. Brown carbon formation from ketoaldehydes of biogenic monoterpenes

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Tran B.; Laskin, Alexander; Laskin, Julia; Nizkorodov, Sergey


    Sources and chemical composition of the brown carbon are poorly understood, and even less is known about the mechanisms of its atmospheric transformations. This work presents molecular level investigation of the reactive compound ketolimononaldehyde (KLA, C9H14O3), a second generation ozonolysis product of limonene (C10H16), as a potent brown carbon precursor in secondary organic aerosol (SOA) through its reactions with reduced nitrogen compounds such as ammonium ion (NH4+), ammonia, and amino acids. The reactions of synthesized and purified KLA with NH4+ and glycine resulted in the formation of chromophores nearly identical in spectral properties and formation rates to those found in similarly-aged limonene/O3 SOA. Similar chemical reaction processes of limononaldehyde (LA, C10H16O2) and pinonaldehyde (PA, C10H16O2), the first-generation ozonolysis products in the oxidation of limonene and α-pinene, respectively, were also studied, but the resulting products did not exhibit light absorption properties of brown carbon, suggesting that the unique molecular structure of KLA produces visible-light-absorbing compounds. The KLA/NH4+ and KLA/GLY reactions produce water-soluble, hydrolysis-resilient chromophores with high mass absorption coefficients (MAC = 2000-4000 cm2 g-1) at λ ~ 500 nm, precisely at the maximum of the solar emission spectrum. Liquid chromatography was used to isolate the light-absorbing fraction, and UV-Vis, FTIR, NMR and high-resolution mass spectrometry (HR-MS) techniques were used to investigate the structures and chemical properties of the light-absorbing compounds. The KLA browning reaction generates a diverse mixture of light-absorbing compounds, with the majority of the observable products containing 1-4 units of KLA and 0-2 nitrogen atoms. Based on the HR-MS product distribution, conjugated aldol condensates, secondary imines (Schiff bases), and N-heterocycles like pyrroles may contribute in varying degree to the light-absorbing properties

  13. Conservation Strategy for Brown Bear and Its Habitat in Nepal

    Directory of Open Access Journals (Sweden)

    Achyut Aryal


    Full Text Available The Himalaya region of Nepal encompasses significant habitats for several endangered species, among them the brown bear (Ursus arctos pruinosus. However, owing to the remoteness of the region and a dearth of research, knowledge on the conservation status, habitat and population size of this species is lacking. Our aim in this paper is to report a habitat survey designed to assess the distribution and habitat characteristics of the brown bear in the Nepalese Himalaya, and to summarize a conservation action plan for the species devised at a pair of recent workshops held in Nepal. Results of our survey showed that brown bear were potentially distributed between 3800 m and 5500 m in the high mountainous region of Nepal, across an area of 4037 km2 between the eastern border of Shey Phoksundo National Park (SPNP and the Manasalu Conservation Area (MCA. Of that area, 2066 km2 lie inside the protected area (350 km2 in the MCA; 1716 km2 in the Annapurna Conservation Area and 48% (1917 km2 lies outside the protected area in the Dolpa district. Furthermore, 37% of brown bear habitat also forms a potential habitat for blue sheep (or bharal, Pseudois nayaur, and 17% of these habitats is used by livestock, suggesting a significant potential for resource competition. Several plant species continue to be uprooted by local people for fuel wood. Based on the results of our field survey combined with consultations with local communities and scientists, we propose that government and non-government organizations should implement a three-stage program of conservation activities for the brown bear. This program should: (a Detail research activities in and outside the protected area of Nepal; (b support livelihood and conservation awareness at local and national levels; and (c strengthen local capacity and reduce human-wildlife conflict in the region.

  14. a Faint and Lonely Brown Dwarf in the Solar Vicinity (United States)


    Discovery of KELU-1 Promises New Insights into Strange Objects Brown Dwarfs are star-like objects which are too small to become real stars, yet too large to be real planets. Their mass is too small to ignite those nuclear processes which are responsible for the large energies and high temperatures of stars, but it is much larger than that of the planets we know in our solar system. Until now, very few Brown Dwarfs have been securely identified as such. Two are members of double-star systems, and a few more are located deep within the Pleiades star cluster. Now, however, Maria Teresa Ruiz of the Astronomy Department at Universidad de Chile (Santiago de Chile), using telescopes at the ESO La Silla observatory, has just discovered one that is all alone and apparently quite near to us. Contrary to the others which are influenced by other objects in their immediate surroundings, this new Brown Dwarf is unaffected and will thus be a perfect object for further investigations that may finally allow us to better understand these very interesting celestial bodies. It has been suggested that Brown Dwarfs may constitute a substantial part of the unseen dark matter in our Galaxy. This discovery may therefore also have important implications for this highly relevant research area. Searching for nearby faint stars The story of this discovery goes back to 1987 when Maria Teresa Ruiz decided to embark upon a long-term search (known as the Calan-ESO proper-motion survey ) for another type of unusual object, the so-called White Dwarfs , i.e. highly evolved, small and rather faint stars. Although they have masses similar to that of the Sun, such stars are no larger than the Earth and are therefore extremely compact. They are particularly interesting, because they most probably represent the future end point of evolution of our Sun, some billions of years from now. For this project, the Chilean astronomer obtained large-field photographic exposures with the 1-m ESO Schmidt telescope at

  15. Metabolic regulation and the anti-obesity perspectives of human brown fat

    DEFF Research Database (Denmark)

    Scheele, Camilla; Nielsen, Søren


    and differentiation of brown fat progenitors. Increasing human BAT capacity could thus include inducing brown fat biogenesis as well as identifying novel batokines. Another attractive approach would be to induce a brown fat phenotype, the so-called brite or beige fat, within the white fat depots. In adult humans......Activation of brown adipose tissue (BAT) in adult humans increase glucose and fatty acid clearance as well as resting metabolic rate, whereas a prolonged elevation of BAT activity improves insulin sensitivity. However, substantial reductions in body weight following BAT activation has not yet been...... shown in humans. This observation raise the possibility for feedback mechanisms in adult humans in terms of a brown fat-brain crosstalk, possibly mediated by batokines, factors produced by and secreted from brown fat. Batokines also seems to be involved in BAT recruitment by stimulating proliferation...

  16. Heated apple juice supplemented with onion has greatly improved nutritional quality and browning index. (United States)

    Lee, Bonggi; Seo, Jeong Dae; Rhee, Jin-Kyu; Kim, Choon Young


    Although fruit juices are very popular, enzymatic browning occurs easily. Browning of fruit juice deteriorates nutrition value and product quality due to oxidation of polyphenol compounds. Therefore, development of natural food additives that reduce browning will be beneficial for improving quality of fruit juices. Onion has been reported to be a potent natural anti-browning agent. Here, we compared unheated and heated apple juices pre-supplemented with onion with respect to browning and nutritional quality. The unheated apple juice supplemented with onion showed reduced browning as well as increased total soluble solid, total phenol concentration, radical scavenging activities, and ferric reducing and copper chelating activities without any change in flavonoid concentration. On the other hand, heated juice supplemented with onion not only showed improved values for these parameters but also markedly increased flavonoid concentration. Thus, we conclude that application of heating and onion addition together may greatly improve quality of apple juice. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Short communication: Reducing agents attenuate methylglyoxal-based browning in Parmesan cheese. (United States)

    Divine, R D; Rankin, S A


    The microbial production of methylglyoxal in cheese has been linked to the formation of brown pigmentation and distinctive volatiles. This study investigated methods for preventing methylglyoxal-induced browning in Parmesan cheese through the addition of reducing agents. Cheeses were treated with the reducing agents sodium bisulfite, glutathione, and erythorbate at 2:1 and 4:1 molar ratios with added methylglyoxal, and then incubated at 10 °C. Colorimetric methods were used to determine degree of browning at 0, 3, and 6 d. Sodium bisulfite and glutathione inhibited the browning reactions of methylglyoxal compared with the control. Erythorbate was much less effective than the other compounds at inhibiting browning, yet was significantly less browned than the control. These reducing agents are thought to act as strong nucleophiles that can form thiohemiketals and thioketals at the carbonyl carbons of methylglyoxal. Copyright © 2013 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  18. Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha

    DEFF Research Database (Denmark)

    Kang, Sona; Bajnok, Laszlo; Longo, Kenneth A


    expression of PGC-1alpha is required for activation of uncoupling protein 1 (UCP1). Wnt10b blocks brown adipose tissue development and expression of UCP1 when expressed from the fatty acid binding protein 4 promoter, even when mice are administered a beta3-agonist. In differentiated brown adipocytes...... expression of PGC-1alpha and UCP1, the presence of unilocular lipid droplets and expression of white adipocyte genes suggest conversion of brown adipose tissue to white. Reciprocal expression of Wnt10b with UCP1 and PGC-1alpha in interscapular tissue from cold-challenged or genetically obese mice provides...... further evidence for regulation of brown adipocyte metabolism by Wnt signaling. Taken together, these data suggest that activation of canonical Wnt signaling early in differentiation blocks brown adipogenesis, whereas activating Wnt signaling in mature brown adipocytes stimulates their conversion to white...

  19. The triumph of the segregationists? A historiographical inquiry into psychology and the Brown litigation. (United States)

    Jackson, J P


    Psychologists testified at the trials of Brown v. Board of Education and helped write briefs that were submitted to the Supreme Court on appeal. Psychologists were once proud of what they did in Brown but are now seen as liberal reformers who masked their political wishes in the guise of social science. The argument that psychologists involved with Brown were social reformers rather than objective scientists dates to the segregationist critique of Brown. The author traces the history of the critique of the Brown psychologists from its segregationist origins to its acceptance by mainstream social scientific and historical scholars. The author concludes that the critique is based on a misreading of what the Brown psychologists did during the litigation.

  20. Biosorption of Heavy Metal Ions to Brown Algae, Macrocystis pyrifera, Kjellmaniella crassiforia, and Undaria pinnatifida


    Seki, Hideshi; Suzuki, Akira


    A fundamental study of the application of brown algae to the aqueous-phase separation of toxic heavy metals was carried out. The biosorption characteristics of cadmium and lead ions were determined with brown algae, Macrocystis pyrifera, Kjellmaniella crassiforia, and Undaria pinnatifida. A metal binding model proposed by the authors was used for the description of metal binding data. The results showed that the biosorption of bivalent metal ions to brown algae was due to bivalent binding to ...

  1. Studies on the effect of brown rice and maize flour on the quality of bread


    M.Z. Islam; M. Shams


    Breads were prepared with various combinations of maize, brown rice and wheat flours in the basic formulation of bread. The baking properties and chemical composition of bread were evaluated and analysed, respectively. The bread volume decreased, where as bread weight and moisture content increased with the increasing level of maize and brown rice flour. The crumb and crust colour of breads were improved with addition of 8% maize and 8% brown rice flour in bread formulation. The protein conte...

  2. Osteomyelitis of the Mandibular Symphysis Caused by Brown Recluse Spider Bite


    Naidu, Deepak K.; Ghurani, Rami; Salas, R. Emerick; Mannari, Rudolph J.; Robson, Martin C.; Payne, Wyatt G.


    Background: Brown recluse spider bites cause significant trauma via their tissue toxic venom. Diagnosis of these injuries and envenomation is difficult and many times presumptive. Treatment is varied and dependent upon presentation and course of injury. Materials and Methods: We present a case of a previously unreported incidence of osteomyelitis of the mandible as a result of a brown recluse spider bite. A review of the literature and discussion of diagnosis and treatment of brown recluse sp...

  3. Cellulose Degradation by Cellulose-Clearing and Non-Cellulose-Clearing Brown-Rot Fungi


    Highley, Terry L.


    Cellulose degradation by four cellulose-clearing brown-rot fungi in the Coniophoraceae—Coniophora prasinoides, C. puteana, Leucogyrophana arizonica, and L. olivascens—is compared with that of a non-cellulose-clearing brown-rot fungus, Poria placenta. The cellulose- and the non-cellulose-clearing brown-rot fungi apparently employ similar mechanisms to depolymerize cellulose; most likely a nonenzymatic mechanism is involved.

  4. The taxonomic status of the Yucatan brown brocket, Mazama pandora (Mammalia: Cervidae) (United States)

    Medellin, R.A.; Gardner, A.L.; Aranda, J.M.


    The Yucatan brown brocket deer, described as Mazama pandora, is now treated as a subspecies of either the common brown brocket, Mazama gouazoubira, or of the red brocket, M. americana. Analysis of brocket deer from Mexico and Central and South America, reveals that the Yucatan brown brocket is sympatric with the red brocket in Mexico and, while similar to M. gouazoubira, warrents recognition as a separate species.

  5. Biosynthetic Pathway and Health Benefits of Fucoxanthin, an Algae-Specific Xanthophyll in Brown Seaweeds


    Mikami, Koji; Hosokawa, Masashi


    Fucoxanthin is the main carotenoid produced in brown algae as a component of the light-harvesting complex for photosynthesis and photoprotection. In contrast to the complete elucidation of the carotenoid biosynthetic pathways in red and green algae, the biosynthetic pathway of fucoxanthin in brown algae is not fully understood. Recently, two models for the fucoxanthin biosynthetic pathway have been proposed in unicellular diatoms; however, there is no such information for the pathway in brown...

  6. Antioxidant Activities of Various Brown Seaweeds from Seribu Islands

    Directory of Open Access Journals (Sweden)

    Seftylia Diachanty


    Full Text Available Brown seaweeds contain various metabolites (carotenoids, laminarin, alginate, fucoidan, mannitol, and phlorotannin as anticancer substances, antioxidants and chemopreventive agent against degenerative diseases. This research was aimed to determine the chemical properties and antioxidants activity of Sargassum polycystum, Padina minor and Turbinaria conoides. This research consisted of the proximate analysis, crude fiber, minerals, heavy metals, extraction, phytochemicals, analysis phenolic compound and antioxidant activity with DPPH, FRAP and CUPRAC methods. The results showed moisture content of S. polycystum, P.  minor, and T. conoides 24-31%, fat 0.23-0,47%, protein 3-4%, ash 27-45%, carbohydrate 26-38% and crude fiber 2-6%. Mineral Fe S. polycystum, P.minor and T.conoides about 0.03 g/kg to 0.39 g/kg, Ca 11.28 g/kg to 27.98 g/kg, K 13.86 g/kg to 41.15 g/kg, Na 16.31 g/kg to 20.51 g/kg and Mg 8.04 g/ kg to 18.68 g/kg. The range of heavy metals Pb S. polycystum, P.  m i n o r  and T. conoides 3.48 mg/kg to 12.68 mg/kg, Hg 0.24 mg/kg to 0.53 mg/kg and Cu 5.66 mg/kg to 7.02 mg/kg. Ethanol extract of S. polycystum, P. minor, and T. conoides contains alkaloids, phenolic, flavonoids, saponins, steroids, and triterpenoids. Total phenolic compounds of brown seaweeds ranged from 3758.97-8287.18 mg GAE/g. Brown seaweeds contain DPPH antioxidant activities within IC50 values of 1.9-9.6 mg/mL, FRAP 70.643-105.357 µmol Trolox/g and CUPRAC 85.268-201 µmol Trolox/g.

  7. Perspective: Does brown fat protect against diseases of aging? (United States)

    Mattson, Mark P


    The most commonly studied laboratory rodents possess a specialized form of fat called brown adipose tissue (BAT) that generates heat to help maintain body temperature in cold environments. In humans, BAT is abundant during embryonic and early postnatal development, but is absent or present in relatively small amounts in adults where it is located in paracervical and supraclavicular regions. BAT cells can 'burn' fatty acid energy substrates to generate heat because they possess large numbers of mitochondria in which oxidative phosphorylation is uncoupled from ATP production as a result of a transmembrane proton leak mediated by uncoupling protein 1 (UCP1). Studies of rodents in which BAT levels are either increased or decreased have revealed a role for BAT in protection against diet-induced obesity. Data suggest that individuals with low levels of BAT are prone to obesity, insulin resistance and cardiovascular disease, whereas those with higher levels of BAT maintain lower body weights and exhibit superior health as they age. BAT levels decrease during aging, and dietary energy restriction increases BAT activity and protects multiple organ systems including the nervous system against age-related dysfunction and degeneration. Future studies in which the effects of specific manipulations of BAT levels and thermogenic activity on disease processes in animal models (diabetes, cardiovascular disease, cancers, neurodegenerative diseases) are determined will establish if and how BAT affects the development and progression of age-related diseases. Data from animal studies suggest that BAT and mitochondrial uncoupling can be targeted for interventions to prevent and treat obesity and age-related diseases. Examples include: diet and lifestyle changes; specific regimens of mild intermittent stress; drugs that stimulate BAT formation and activity; induction of brown adipose cell progenitors in muscle and other tissues; and transplantation of brown adipose cells. Copyright 2009

  8. The role of active brown adipose tissue in human metabolism

    Energy Technology Data Exchange (ETDEWEB)

    Ozguven, Salih; Turoglu, H.T. [S.B. Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi, Department of Nuclear Medicine, Istanbul (Turkey); Ones, Tunc [S.B. Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi, Department of Nuclear Medicine, Istanbul (Turkey); Kozyatagi/Kadikoy, Istanbul (Turkey); Yilmaz, Yusuf; Imeryuz, Nese [S.B. Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi, Department of Internal Medicine, Division of Gastroenterology, Istanbul (Turkey)


    The presence of activated brown adipose tissue (ABAT) has been associated with a reduced risk of obesity in adults. We aimed to investigate whether the presence of ABAT in patients undergoing {sup 18}F-FDG PET/CT examinations was related to blood lipid profiles, liver function, and the prevalence of non-alcoholic fatty liver disease (NAFLD). We retrospectively and prospectively analysed the {sup 18}F-FDG PET/CT scans from 5,907 consecutive patients who were referred to the Nuclear Medicine Department of the Marmara University School of Medicine from outpatient oncology clinics between July 2008 and June 2014 for a variety of diagnostic reasons. Attenuation coefficients for the liver and spleen were determined for at least five different areas. Blood samples were obtained before PET/CT to assess the blood lipid profiles and liver function. A total of 25 of the 5,907 screened individuals fulfilling the inclusion criteria for the study demonstrated brown fat tissue uptake [ABAT(+) subjects]. After adjustment for potential confounders, 75 individuals without evidence of ABAT on PET [ABAT(-) subjects] were enrolled for comparison purposes. The ABAT(+) group had lower total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, and aspartate transaminase levels (p < 0.01), whereas we found no significant differences in the serum triglyceride and high-density lipoprotein cholesterol levels between the two groups. The prevalence of NAFLD was significantly lower in ABAT(+) than in ABAT(-) subjects (p < 0.01). Our study showed that the presence of ABAT in adults had a positive effect on their blood lipid profiles and liver function and was associated with reduced prevalence of NAFLD. Thus, our data suggest that activating brown adipose tissue may be a potential target for preventing and treating dyslipidaemia and NAFLD. (orig.)


    Directory of Open Access Journals (Sweden)

    Ira Djajanegara


    Full Text Available Genetic crossing of white oyster mushroom (Pleurotus floridae to introduce longer storage life trait can only be done within individuals in this particular species. However, longer storage life trait is possessed by brown oyster mushroom (Pleurotus cystidiosus. Therefore, a protoplast fusion experiment between white and brown oyster mushrooms was conducted to obtain an oyster mushroom strain showing high productivity and long storage life. The experiment was done at the biology laboratory of the University of Al Azhar Indonesia from May 2008 to August 2009. Protoplast fusion was done by isolating protoplast from 5-day old monokaryotic mycelia grown in potato dextrose broth (PDB. Around 3.15 x 105 protoplasts ml-1 were harvested using mixture of cellulase Onozuka R-10 (1% and macerozyme R-10 (1% from brown oyster mushroom with 80.61% viability. Similarly, 3.71 x 105 protoplasts ml-1 were harvested using lysing enzyme (2% from white oyster mushroom with 83.68% viability. Protoplast fusions were conducted using 40% PEG6000 for 10 minutes. The candidate fusants were then screened using minimum regeneration media (MRM. There were 22 colonies grew on MRM media and four colonies (FS1, FS2, FS3, and FS4 showed clamp connection as well as primordia formation to be chosen as candidate fusants. However, isozyme studies using malate dehydrogenase and acid phosphatase as marker enzymes confirmed that only FS1 and FS2 were the hybridized products. The two colonies showed different mycelia growth patterns and hyphae sizes, fruit body morphology and productivity compared to their parents. These two fusants, however, did not indicate the presence of longer storage life trait as expected despite a higher productivity achieved by FS1. In this study, the protoplast fusion only yielded higher productivity strain of mushroom with different colors without any changes in storage life.

  10. Phylogeography of mitochondrial DNA variation in brown bears and polar bears (United States)

    Shields, Gerald F.; Adams, Deborah; Garner, Gerald W.; Labelle, Martine; Pietsch, Jacy; Ramsay, Malcolm; Schwartz, Charles; Titus, Kimberly; Williamson, Scott


    We analyzed 286 nucleotides of the middle portion of the mitochondrial cytochrome b gene of 61 brown bears from three locations in Alaska and 55 polar bears from Arctic Canada and Arctic Siberia to test our earlier observations of paraphyly between polar bears and brown bears as well as to test the extreme uniqueness of mitochondrial DNA types of brown bears on Admiralty, Baranof, and Chichagof (ABC) islands of southeastern Alaska. We also investigated the phylogeography of brown bears of Alaska's Kenai Peninsula in relation to other Alaskan brown bears because the former are being threatened by increased human development. We predicted that: (1) mtDNA paraphyly between brown bears and polar bears would be upheld, (2) the mtDNA uniqueness of brown bears of the ABC islands would be upheld, and (3) brown bears of the Kenai Peninsula would belong to either clade II or clade III of brown bears of our earlier studies of mtDNA. All of our predictions were upheld through the analysis of these additional samples.

  11. Variation in natural selection for growth and phlorotannins in the brown alga Fucus vesiculosus

    National Research Council Canada - National Science Library

    Jormalainen, V; Honkanen, T


    .... We explore both the amount of genetic variation and variability of natural selection for growth and concentration of phenolic secondary compounds, phlorotannins, in the brown alga Fucus vesiculosus...

  12. Brown tumor of the mandible as first manifestation of primary hyperparathyroidism: diagnosis and treatment. (United States)

    Fernández-Sanromán, Jacinto; Antón-Badiola, Iosu María; Costas-López, Alberto


    Brown tumor is one of the lesions that develop in patients with hyperparathyroidism. Any of the skeletal bones can be affected including the cranio-maxillofacial ones. Most of the times the brown tumor appears after a final diagnosis of hyperparathyroidism is made. However brown tumor can be the first clinical sign of the disease. A clinical case in which a brown tumor located in the anterior part of the mandible appears as the first sign of primary hyperparathyroidism is presented. The possible differential clinical diagnosis and the recommended treatments are revised.

  13. Interspecific interactions between brown trout and slimy sculpin in stream enclosures (United States)

    Ruetz, C. R.; Hurford, A.L.; Vondracek, B.


    We conducted a 30-d manipulative experiment in Valley Creek, Minnesota, to examine interspecific interactions between juvenile brown trout Salmo trutta and adult slimy sculpin Cottus cognatus. We measured the instantaneous growth of each species in the presence and absence of the other in 1-m2 enclosures. We tested single-species (three slimy sculpins/m2 or three brown trout/m2) and combined-species (three sculpins/m2 and three trout/m2) combinations in each of six riffles. We placed a clay tile in each enclosure to evaluate the effects of fish combinations on benthic macroinvertebrates. Growth of brown trout was unaffected by the presence of slimy sculpins (P = 0.647, power [to detect 50% increase in growth] = 0.92), whereas slimy sculpin growth was less in the presence of brown trout (P = 0.038). Densities of total benthic macroinvertebrates, Chironomidae, Trichoptera, and Physa did not differ among fish combinations (P > 0.3). However, densities of Gammarus pseudolimnaeus were significantly less in the presence of brown trout irrespective of the presence of slimy sculpins (P = 0.024), which could be a causal factor underlying the interaction between brown trout and slimy sculpins. We found asymmetrical competition between brown trout and slimy sculpins in stream enclosures, with brown trout being the superior competitor. Nevertheless, the size of enclosures may have biased our results, making it more likely to detect an effect of brown trout on slimy sculpins than vice versa.

  14. Application of the sake cake from pre-germinated brown rice for food use


    牛越, 静子; 小木曽, 加奈


    Pre-germinated brown rice prepared by soaking brown rice in 37℃ water for 24-48 hours to initiate germination of sprouts not exceeding 0.5-1.0 mm in length. On the other hand, the rice bran and the embryo bud are removed from the brewer's rice brown rice during the brewing of sake, because of removing a rough taste. It is thought that sake and sake cake that fermented the pre-germinated brown rice remained without removing the element of the rice bran and the embryo bud. However, the sake m...

  15. Hanbury Brown-Twiss effect with electromagnetic waves. (United States)

    Hassinen, T; Tervo, J; Setälä, T; Friberg, A T


    The classic Hanbury Brown-Twiss experiment is analyzed in the space-frequency domain by taking into account the vectorial nature of the radiation. We show that as in scalar theory, the degree of electromagnetic coherence fully characterizes the fluctuations of the photoelectron currents when a random vector field with Gaussian statistics is incident onto the detectors. Interpretation of this result in terms of the modulations of optical intensity and polarization state in two-beam interference is discussed. We demonstrate that the degree of cross-polarization may generally diverge. We also evaluate the effects of the state of polarization on the correlations of intensity fluctuations in various circumstances.

  16. Students Use VLA to Make Startling Brown-Dwarf Discovery (United States)


    A group of summer students making a long-shot astronomical gamble with the National Science Foundation's (NSF) Very Large Array (VLA) have found the first radio emission ever detected from a brown dwarf, an enigmatic object that is neither a star nor a planet, but something in between. Their surprising discovery is forcing experts to re-think their theories about how brown dwarfs work. The Very Large Array "Many astronomers are surprised at this discovery, because they didn't expect such strong radio emission from this object," said Shri Kulkarni, a Caltech professor who was on the team that first discovered a brown dwarf in 1995, and advisor to one of the students. "What is so cool is that this is research that probably nobody else would have tried to do because of its low chance of success. That made it ideal for summer students -- we had almost nothing to lose," said Kate Becker, a student at Oberlin College in Ohio. "The radio emission these students discovered coming from this brown dwarf is 10,000 times stronger than anyone expected," said Dale Frail, an astronomer at the National Radio Astronomy Observatory (NRAO) in Socorro, NM. "This student project is going to open up a whole new area of research for the VLA," Frail added. The students, in addition to Becker, are: Edo Berger from Caltech; Steven Ball from New Mexico Tech in Socorro, NM; Melanie Clarke from Carleton College in Northfield, MN; Therese Fukuda from the University of Denver; Ian Hoffman from the University of New Mexico in Albuquerque; Richard Mellon from The Pennsylvania State University; Emmanuel Momjian from the University of Kentucky; Nathanial Murphy from Amherst College in Amherst, MA; Stacey Teng from the University of Maryland; Timothy Woodruff from Southwestern University in Georgetown, TX; Ashley Zauderer from Agnes Scott College in Decatur, GA; and Robert Zavala from New Mexico State University in Las Cruces, NM. Frail also is an author of the research paper, published in the March

  17. Animal welfare in brown trout farming: hematological results

    Directory of Open Access Journals (Sweden)

    G. Forneris


    Full Text Available The effect of stress resulting from fish farming has received considerable attention in this last period and fish welfare in aquaculture is a relevant topic, very important for the future of aquaculture (Watson et al., 2004; Klinger et al., 1996; Peres et al., 2004; Ron et al., 1995;Wagner et al., 1995;Watson et al., 1998. Brown trout farming is less developed then rainbow trout farming, but this kind of fish farming is increasing, mainly for fish conservation and restocking aquaculture.

  18. Ophthalmic patterns of captive brown brocket deer (Mazama gouazoubira). (United States)

    Martins, Bianca C; Oriá, Arianne P; Souza, Ana L G; Campos, Carla F; Almeida, Denise E; Duarte, Roberta A; Soares, Christiane P; Zuanon, José A S; Neto, Carlos B; Duarte, José M B; Schocken-Iturrino, Rubén P; Laus, José L


    Captive brown brocket deer (Mazama gouazoubira) were manually restrained to assess tear production by the Schirmer tear test I to measure intraocular pressure by applanation tonometry, to examine ocular conjunctival epithelial cells via cytologic and histologic samples, and to survey ocular conjunctival microflora by microbiologic culture. The mean value for the Schirmer tear test I was 8.9 +/- 1.8 mm/min, and the mean intraocular pressure was 15.3 +/- 3.1 mm Hg. Conjunctival epithelium contained stratified pavimentous layers of cells, and the microflora consisted of predominantly gram-positive bacteria.

  19. Microlensing of unresolved stars as a brown dwarf detection method

    CERN Document Server

    Bouquet, A; Melchior, A L; Giraud-Héraud, Yannick; Baillon, Paul


    We describe a project of brown dwarf detection in the dark halo of a galaxy using the microlensing effect. We argue that monitoring pixels instead of stars could provide an enhancement in the number of detectable events. We estimate the detection efficiency with a Monte-Carlo simulation. We expect a ten-fold increase with respect to current experiments. To assess the feasibility of this method we have determined the photometric precision of a pixel by comparing several pictures of a same field in the LMC. To be published in the Proceeding of the workshop 'The dark side of the universe...', Roma, Juin 1993,

  20. Clouds and hazes in exoplanets and brown dwarfs (United States)

    Morley, Caroline Victoria

    The formation of clouds significantly alters the spectra of cool substellar atmospheres from terrestrial planets to brown dwarfs. In cool planets like Earth and Jupiter, volatile species like water and ammonia condense to form ice clouds. In hot planets and brown dwarfs, iron and silicates instead condense, forming dusty clouds. Irradiated methane-rich planets may have substantial hydrocarbon hazes. During my dissertation, I have studied the impact of clouds and hazes in a variety of substellar objects. First, I present results for cool brown dwarfs including clouds previously neglected in model atmospheres. Model spectra that include sulfide and salt clouds can match the spectra of T dwarf atmospheres; water ice clouds will alter the spectra of the newest and coldest brown dwarfs, the Y dwarfs. These sulfide/salt and ice clouds potentially drive spectroscopic variability in these cool objects, and this variability should be distinguishable from variability caused by hot spots. Next, I present results for small, cool exoplanets between the size of Earth and Neptune. They likely have sulfide and salt clouds and also have photochemical hazes caused by stellar irradiation. Vast resources have been dedicated to characterizing the handful of super Earths and Neptunes accessible to current telescopes, yet of the planets smaller than Neptune studied to date, all have radii in the near-infrared consistent with being constant in wavelength, likely showing that these small planets are consistently enshrouded in thick hazes and clouds. For the super Earth GJ 1214b, very thick, lofted clouds of salts or sulfides in high metallicity (1000x solar) atmospheres create featureless transmission spectra in the near-infrared. Photochemical hazes also create featureless transmission spectra at lower metallicities. For the Neptune-sized GJ 436b, its thermal emission and transmission spectra combine indicate a high metallicity atmosphere, potentially heated by tides and affected by

  1. Tubulopapillary mammary carcinoma in a brown bear (Ursus arctos). (United States)

    Nak, Deniz; Cangul, I Taci; Nak, Yavuz; Cihan, Huseyin; Celimli, Nureddin


    A 28-yr-old, nulliparous female brown bear (Ursus arctos) at the Karacabey Ovakurusu Bear Sanctuary presented with an enlargement of the mammary gland. Three other nodules were also noted in the proximity of the mammary gland and over the vulva. Clinical, hematologic, ultrasonographic, and radiologic examinations were performed; the enlarged mammary gland was removed and the other masses were also excised. Histopathologic examination revealed tubulopapillary carcinoma of the mammary gland, and the other masses were diagnosed as epidermoid cysts. This is the first reported case of tubulopapillary mammary carcinoma accompanied by epidermoid cysts in a bear.

  2. Youngest Brown Dwarf Yet in a Multiple Stellar System (United States)


    ... and the Sharpest Optical Image (0.18 arcsec) from the VLT so far...! Astronomers are eager to better understand the formation of stars and planets - with an eye on the complex processes that lead to the emergence of our own solar system some 4600 million years ago. Brown Dwarfs (BDs) play a special role in this context. Within the cosmic zoo, they represent a class of "intermediate" objects. While they are smaller than normal stars, they shine by their own energy for a limited time, in contrast to planets. Recent observations with the ESO Very Large Telescope (VLT) of a "young" Brown Dwarf in a multiple stellar system are taking on a particular importance in this connection. An evaluation of the new data by an international team of astronomers [1] shows that it is by far the youngest of only four such objects found in a stellar system so far. The results are now providing new insights into the stellar formation process. This small object is known as TWA-5 B and with a mass of only 15 - 40 times that of Jupiter, it is near the borderline between planets and Brown Dwarfs, cf. the explanatory Appendix to this Press Release. However, visible and infrared VLT spectra unambiguously classify it in the latter category. Accurate positional measurements with the Hubble Space Telescope (HST) and the VLT hint that it is orbiting the central, much heavier and brighter star in this system, TWA-5 A (itself a close double star of which each component presumably has a mass of 0.75 solar masses), with a period that may be as long as 900 years. And, by the way, an (I-band) image of the TWA-5 system is the sharpest delivered by the VLT so far, with an image size of only 0.18 arcsec [2]! Brown Dwarfs: a cool subject In current astronomical terminology, Brown Dwarfs (BDs) are objects whose masses are below those of normal stars - the borderline is believed to be about 8% of the mass of our Sun - but larger than those of planets, cf. [3]. Unlike normal stars, Brown Dwarfs are unable

  3. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

    DEFF Research Database (Denmark)

    Barbatelli, G.; Murano, I.; Madsen, Lise


    The origin of brown adipocytes arising in white adipose tissue (WAT) after cold acclimatization is unclear. Here, we demonstrate that several UCP1-immunoreactive brown adipocytes occurring in WAT after cold acclimatization have a mixed morphology (paucilocular adipocytes). These cells also had a ...... for C/EBP (an antimitotic protein), whereas Ccna1 expression (related to cell proliferation) was unchanged. Overall, our data strongly suggest that the cold-induced emergence of brown adipocytes in WAT predominantly reflects ß3-adrenoceptor-mediated transdifferentiation....

  4. Síndrome de Brown: A propósito de 12 casos Brown's syndrome: Apropos of 12 cases


    Alina Pedroso Llanes; Teresita de J Méndez Sánchez; Rosa M Naranjo Fernández; Carmen M Padilla González


    Se realizó un estudio descriptivo retrospectivo de 12 pacientes con diagnóstico de síndrome de Brown, que asistieron a la Consulta de Oftalmología Pediátrica y Estrabismo del Hospital Oftalmológico Docente "Ramón Pando Ferrer" desde enero del 1999 a enero de 2000 con los objetivos de precisar la frecuencia del ojo afectado y el grado de severidad del síndrome, identificar los síntomas presentes que motivaron la consulta, determinar los criterios que decidieron la intervención quirúrgica y des...

  5. The brown dwarf atmosphere monitoring (BAM) project - II. Multi-epoch monitoring of extremely cool brown dwarfs (United States)

    Rajan, A.; Patience, J.; Wilson, P. A.; Bulger, J.; De Rosa, R. J.; Ward-Duong, K.; Morley, C.; Pont, F.; Windhorst, R.


    With the discovery of Y dwarfs by the WISE mission, the population of field brown dwarfs now extends to objects with temperatures comparable to those of Solar system planets. To investigate the atmospheres of these newly identified brown dwarfs, we have conducted a pilot study monitoring an initial sample of three late-T dwarfs (T6.5, T8 and T8.5) and one Y dwarf (Y0) for infrared photometric variability at multiple epochs. With J-band imaging, each target was observed for a period of 1.0-4.5 h per epoch, which covers a significant fraction of the expected rotational period. These measurements represent the first photometric monitoring for these targets. For three of the four targets (2M1047, Ross 458C and WISE0458), multi-epoch monitoring was performed, with the time span between epochs ranging from a few hours to ˜2 years. During the first epoch, the T8.5 target WISE0458 exhibited variations with a remarkable min-to-max amplitude of 13 per cent, while the second epoch light curve taken ˜2 years later did not note any variability to a 3 per cent upper limit. With an effective temperature of ˜600 K, WISE0458 is the coldest variable brown dwarf published to date, and combined with its high and variable amplitude makes it a fascinating target for detailed follow-up. The three remaining targets showed no significant variations, with a photometric precision between 0.8 and 20.0 per cent, depending on the target brightness. Combining the new results with previous multi-epoch observations of brown dwarfs with spectral types of T5 or later, the currently identified variables have locations on the colour-colour diagram better matched by theoretical models incorporating cloud opacities rather than cloud-free atmospheres. This preliminary result requires further study to determine if there is a definitive link between variability among late-T dwarfs and their location on the colour-colour diagram.

  6. Broad-scale patterns of Brook Trout responses to introduced Brown Trout in New York (United States)

    McKenna, James E.; Slattery, Michael T.; Kean M. Clifford,


    Brook Trout Salvelinus fontinalis and Brown Trout Salmo trutta are valuable sport fish that coexist in many parts of the world due to stocking introductions. Causes for the decline of Brook Trout within their native range are not clear but include competition with Brown Trout, habitat alteration, and repetitive stocking practices. New York State contains a large portion of the Brook Trout's native range, where both species are maintained by stocking and other management actions. We used artificial neural network models, regression, principal components analysis, and simulation to evaluate the effects of Brown Trout, environmental conditions, and stocking on the distribution of Brook Trout in the center of their native range. We found evidence for the decline of Brook Trout in the presence of Brown Trout across many watersheds; 22% of sampled reaches where both species were expected to occur contained only Brown Trout. However, a model of the direct relationship between Brook Trout and Brown Trout abundance explained less than 1% of data variation. Ordination showed extensive overlap of Brook Trout and Brown Trout habitat conditions, with only small components of the hypervolume (multidimensional space) being distinctive. Subsequent analysis indicated higher abundances of Brook Trout in highly forested areas, while Brown Trout were more abundant in areas with relatively high proportions of agriculture. Simulation results indicated that direct interactions and habitat conditions were relatively minor factors compared with the effects of repeated stocking of Brown Trout into Brook Trout habitat. Intensive annual stocking of Brown Trout could eliminate resident Brook Trout in less than a decade. Ecological differences, harvest behavior, and other habitat changes can exacerbate Brook Trout losses. Custom stocking scenarios with Brown Trout introductions at relatively low proportions of resident Brook Trout populations may be able to sustain healthy populations of both

  7. Movements and activity of juvenile Brown Treesnakes (Boiga irregularis) (United States)

    Lardner, Bjorn; Savidge, Julie A.; Reed, Robert N.; Rodda, Gordon H.


    Understanding the spatial ecology and foraging strategy of invasive animals is essential for success in control or eradication. We studied movements and activity in juvenile Brown Treesnakes on Guam, as this population segment has proven particularly difficult to control. Distance between daytime refugia (from telemetry of 18 juveniles, 423-800 mm snout-vent length) ranged from 0-118 m (n  =  86), with a grand mean of 43 m. There were tendencies for shorter snake movements on nights directly following a full moon and on dry nights, but variation among snakes was of a larger magnitude and would greatly reduce chances to detect moon or rain effects unless corrected for. Snake activity was estimated from audio recordings of signals from “tipping” radio transmitters, analyzed for pulse period and amplitude. Activity was highest in the hours immediately after sunset, and gradually declined throughout the night before dropping abruptly in conjunction with sunrise. Snake activity was higher on rainy nights, and tended to be highest during waning moons and when the moon was below the horizon. We conclude that small Brown Treesnakes forage actively and appear to move far enough to regularly encounter the traps and bait used on Guam for control purposes, suggesting that alternative explanations are required for their low capture rates with these control tools.

  8. Brown adipose tissue: Updates in cellular and molecular biology. (United States)

    Bargut, Thereza Cristina Lonzetti; Aguila, Marcia Barbosa; Mandarim-de-Lacerda, Carlos Alberto


    Brown adipose tissue (BAT) is mainly composed of adipocytes, it is highly vascularized and innervated, and can be activated in adult humans. Brown adipocytes are responsible for performing non-shivering thermogenesis, which is exclusively mediated by uncoupling protein (UCP) -1 (a protein found in the inner mitochondrial membrane), the hallmark of BAT, responsible for the uncoupling of the proton leakage from the ATP production, therefore, generating heat (i.e. thermogenesis). Besides UCP1, other compounds are essential not only to thermogenesis, but also to the proliferation and differentiation of BAT, including peroxisome proliferator-activated receptor (PPAR) family, PPARgamma coactivator 1 (PGC1)-alpha, and PRD1-BF-1-RIZ1 homologous domain protein containing protein (PRDM) -16. The sympathetic nervous system centrally regulates thermogenesis through norepinephrine, which acts on the adrenergic receptors of BAT. This bound leads to the initialization of the many pathways that may activate thermogenesis in acute and/or chronic ways. In summary, this mini-review aims to demonstrate the latest advances in the knowledge of BAT. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Spatial behaviour and survival of translocated wild brown hares

    Directory of Open Access Journals (Sweden)

    Fischer, C.


    Full Text Available The fragility of many populations of brown hares in Western Europe is a concern for managers, hunters and naturalists. We took advantage of a locally high density population to use wild individuals to restock areas where the species had disappeared or was close to disappearing. The aim of the project was to assess the evolution of the spatial behaviour after release using radio–tracking. Over 150 wild brown hares were translocated, one third of which were fitted with radio collars. In addition, fifteen individuals were radio–tagged and released back into the source population as a control. Most individuals settled in less than two months and their seasonal home range, once settled, was similar to that observed in the source population. Mean duration of tracking was not significantly different between the two groups. Moreover, two years after the last translocation, tagged individuals can still be observed, but most hares present are not tagged, which indicates natural reproduction of the released individuals. The translocation of wild individuals thus appears to give encouraging results.

  10. Distinct fatty acid profile of ten brown macroalgae

    Directory of Open Access Journals (Sweden)

    Graça Silva


    Full Text Available It is widely accepted that the consumption of ω-3 polyunsaturated fatty acids has beneficial effects on human health. In this work, ten brown macroalgae species collected along the Portuguese west coast were studied for their fatty acids composition by GC-MS after alkaline hydrolysis and derivatization. The results of this survey showed that different macroalgae from the same region display distinct fatty acids profile. Concerning ω-3 polyunsaturated fatty acids, eicosapentaenoic acid was found in all but one species. Additionally, some species contained docosahexaenoic acid. Linoleic acid, an essential fatty acid of the ω-6 series, was present in all studied macroalgae. Fucus spiralis L. exhibited the highest amounts of monounsaturated fatty acids and of polyunsaturated fatty acids of the ω-3 and ω-6 series. The ω-6/ω-3 ratio in half of the studied species was lower than 1. This information reinforces the potential application of some brown macroalgae as dietary sources of polyunsaturated fatty acids.

  11. Efficient Isolation of Cardiac Stem Cells from Brown Adipose

    Directory of Open Access Journals (Sweden)

    Zhiqiang Liu


    Full Text Available Cardiac stem cells represent a logical cell type to exploit in cardiac regeneration. The efficient harvest of cardiac stem cells from a suitable source would turn promising in cardiac stem cell therapy. Brown adipose was recently found to be a new source of cardiac stem cells, instrumental to myocardial regeneration. Unfortunately, an efficient method for the cell isolation is unavailable so far. In our study we have developed a new method for the efficient isolation of cardiac stem cells from brown adipose by combining different enzymes. Results showed that the total cell yield dramatically increased (more than 10 times, P<.01 compared with that by previous method. The content of CD133-positive cells (reported to differentiate into cardiomyocytes with a high frequency was much higher than that in the previous report (22.43% versus 3.5%. Moreover, the isolated cells could be the efficiently differentiated into functional cardiomyocytes in optimized conditions. Thus, the new method we established would be of great use in further exploring cardiac stem cell therapy.

  12. Classification of communication signals of the little brown bat. (United States)

    Melendez, Karla V; Jones, Douglas L; Feng, Albert S


    Little brown bats, Myotis lucifugus, are known for their ability to echolocate and utilize their echolocation system to navigate, and locate and identify prey. Their echolocation signals have been characterized in detail but their communication signals are less well understood despite their widespread use during social interactions. The goal of this study was to develop an automatic classification algorithm for characterizing the communication signals of little brown bats. Sound recordings were made overnight on five individual male bats (housed separately from a large group of captive bats) for 7 nights, using a bat detector and a digital recorder. The spectral and temporal characteristics of recorded sounds were first analyzed and classified by visual observation of a call's temporal pattern and spectral composition. Sounds were later classified using an automatic classification scheme based on multivariate statistical parameters in MATLAB. Human- and machine-based analysis revealed five discrete classes of bat's communication signals: downward frequency-modulated calls, steep frequency-modulated calls, constant frequency calls, broadband noise bursts, and broadband click trains.

  13. Brown tumor of the maxilla in patient with secondary hyperparathyroidism

    Directory of Open Access Journals (Sweden)

    Jović Nebojša


    Full Text Available Brown tumor or parathyroid osteopathy is a kind of bony lesion caused by hyperparathyroidism. It appears as an expansive osteolytic lesion mostly in mandible, ribs, pelvis and femur, but rarely in the upper jaw. Bone resorption is the result of osteoclastic activity due to an increased activity of parathyroid hormone. A 25-years-old male patient was operated on due to clinicaly and radiographicaly obvious maxillary tumor and increased values of parathyroid hormon (PTH - 1 050 ng/l. The level of calcium in blood was normal (Ca 2.34 mEq/L. The patient was dialyzed for years because of the chronic renal failure. Histopathologic analysis confirmed brown tumor, that appeared as bony lesion of secondary hyperparathyroidism due to the chronic renal failure. The operation of the upper jaw had been performed before parathyroidectomy, due to an excessive growth of tumor followed by heavy epistaxes. The subsequent parathyroidectomy was followed by the regression of remaining bony lesions.

  14. Behavioural Profiles of Brown and Sloth Bears in Captivity. (United States)

    Pastorino, Giovanni Quintavalle; Christodoulides, Yiannis; Curone, Giulio; Pearce-Kelly, Paul; Faustini, Massimo; Albertini, Mariangela; Preziosi, Richard; Mazzola, Silvia Michela


    Three brown bear (Ursusarctosarctos) individuals and two sloth bear (Melursusursinusinornatus) individuals were observed in captivity to produce behavioural profiles for each individual. Data collected through behavioural observations were used to produce activity budgets, and to identify space usage and certain aspects of social behavior. Behaviour monitoring allowed the researchers to evaluate the welfare of the animals by identifying the occurrence of stereotypic behaviours, which are sometimes associated with stress. Behavioural profiles were created using data obtained through behavioural observations (coding) and keeper questionnaires (rating). The behavioural observations indicated a number of stereotypic behaviours in sloth bears but not in brown bears. The uniformity of zone usage was calculated to investigate if the enclosure size and features were adequate for use, and a social aspect of otherwise solitary animals was also identified. The behavioural profiles generated through coding and rating were compared to determine the reliability between these two methods in Ursids. Profiles were not compared between individuals since this study is not a comparison between different personality types but rather an effort (one of the few ones existing in literature) to select a valid and reproducible methodology capable of assessing personality in bears.

  15. Enteric coccidiosis in the brown kiwi (Apteryx mantelli). (United States)

    Morgan, K J; Alley, M R; Pomroy, W E; Castro, I; Howe, L


    Enteric coccidiosis may cause significant morbidity and mortality in juvenile brown kiwi (Apteryx mantelli). Morphology of sporulated oocysts indicates that at least two Eimeria species are able to infect the brown kiwi. A histological study of the endogenous stages of coccidia was undertaken in the intestinal tracts of ten naturally infected young kiwi. Sequential sectioning of the entire intestinal tract allowed identification and recording of the distribution of the various coccidial life stages. Macromeronts measuring 268 × 162 μm when mature were found mainly within the lamina propria of the proximal one third of the small intestine. A smaller form of lamina propria meront was also identified (8.7 × 6.4 μm) with a similar distribution to the macromeronts. Small meronts (4.4 × 3.8 μm) were also identified in mucosal epithelial cells, with the overall peak in distribution within the intestinal tract being distal to the lamina propria meronts. Three morphologically distinctive gametocytes were identified. Type A gametocytes contained within epithelial cells shared the same distribution as the epithelial meronts. Polyps containing large numbers of type B gametocytes within the distal intestinal tract were found in two cases, and type C gametocytes were identified throughout the entire intestinal tract in one case only. The observational nature of this study precludes complete knowledge of the parasite life cycles using histology alone. However, it is likely that each of the three morphologically distinct gametocytes represents a separate species of enteric coccidia.

  16. Recent ecological transitions in China: greening, browning, and influential factors. (United States)

    Lü, Yihe; Zhang, Liwei; Feng, Xiaoming; Zeng, Yuan; Fu, Bojie; Yao, Xueling; Li, Junran; Wu, Bingfang


    Ecological conservation and restoration are necessary to mitigate environmental degradation problems. China has taken great efforts in such actions. To understand the ecological transition during 2000-2010 in China, this study analysed trends in vegetation change using remote sensing and linear regression. Climate and socioeconomic factors were included to screen the driving forces for vegetation change using correlation or comparative analyses. Our results indicated that China experienced both vegetation greening (restoration) and browning (degradation) with great spatial heterogeneity. Socioeconomic factors, such as human populations and economic production, were the most significant factors for vegetation change. Nature reserves have contributed slightly to the deceleration of vegetation browning and the promotion of greening; however, a large-scale conservation approach beyond nature reserves was more effective. The effectiveness of the Three-North Shelter Forest Program lay between the two above approaches. The findings of this study highlighted that vegetation trend detection is a practical approach for large-scale ecological transition assessments, which can inform decision-making that promotes vegetation greening via proper socioeconomic development and ecosystem management.

  17. Efficient xylose fermentation by the brown rot fungus Neolentinus lepideus. (United States)

    Okamoto, Kenji; Kanawaku, Ryuichi; Masumoto, Masaru; Yanase, Hideshi


    The efficient production of bioethanol on an industrial scale requires the use of renewable lignocellulosic biomass as a starting material. A limiting factor in developing efficient processes is identifying microorganisms that are able to effectively ferment xylose, the major pentose sugar found in hemicellulose, and break down carbohydrate polymers without pre-treatment steps. Here, a basidiomycete brown rot fungus was isolated as a new biocatalyst with unprecedented fermentability, as it was capable of converting not only the 6-carbon sugars constituting cellulose, but also the major 5-carbon sugar xylose in hemicelluloses, to ethanol. The fungus was identified as Neolentinus lepideus and was capable of assimilating and fermenting xylose to ethanol in yields of 0.30, 0.33, and 0.34 g of ethanol per g of xylose consumed under aerobic, oxygen-limited, and anaerobic conditions, respectively. A small amount of xylitol was detected as the major by-product of xylose metabolism. N. lepideus produced ethanol from glucose, mannose, galactose, cellobiose, maltose, and lactose with yields ranging from 0.34 to 0.38 g ethanol per g sugar consumed, and also exhibited relatively favorable conversion of non-pretreated starch, xylan, and wheat bran. These results suggest that N. lepideus is a promising candidate for cost-effective and environmentally friendly ethanol production from lignocellulosic biomass. To our knowledge, this is the first report on efficient ethanol fermentation from various carbohydrates, including xylose, by a naturally occurring brown rot fungus. Copyright © 2011 Elsevier Inc. All rights reserved.

  18. Changes in brown eggshell color as the hen ages. (United States)

    Odabaşi, A Z; Miles, R D; Balaban, M O; Portier, K M


    The color of eggshells from eggs laid by commercial-type Hy-Line brown hens 25 wk of age was studied over a period of 10 mo. Color measurements were made by a color machine vision system and were analyzed using a mixed model to calculate between and within hen variances and to investigate the effect of time on shell color. Hens laid eggs with lighter colored shells as the flock aged, as evidenced by the lightness (L*) values increasing in time. A decrease in pigmentation was associated with a decrease in the amount of redness (a*) in the eggshell. When L* and a* values were corrected for egg weight, the rate of change in the L* and a* values decreased, indicating that size of the egg was a major factor affecting the color of the eggshell. These findings quantified the observations that older hens lay lighter colored eggs due to an increase in egg size associated with no proportionate change in the quantity of pigment deposited over the shell surface. Using a 2-stage sampling analysis and the variances between and within hens, sample sizes required to estimate the color of eggshells within 5% of the true mean were calculated. Accordingly, 11 eggs would need to be collected from each of the 51 hens housed for a study of brown eggshell color using the L*, a*, and b* (yellowness) coordinates.

  19. Indications of Water Clouds in the Coldest Known Brown Dwarf (United States)

    Faherty, Jacqueline K.; Tinney, C. G.; Skemer, Andrew; Monson, Andrew J.


    We present a deep near-infrared image of the newly discovered brown dwarf WISE J085510.83-071442.5 (W0855) using the FourStar imager at Las Campanas Observatory. Our detection of J3 = 24.8^{+0.53}_{-0.35} (J MKO = 25.0^{+0.53}_{-0.35}) at 2.6σ—or equivalently an upper limit of J3 > 23.8 (J MKO > 24.0) at 5σ makes W0855 the reddest brown dwarf ever categorized (J MKO - W2 = 10.984^{+0.53}_{-0.35} at 2.6σ—or equivalently an upper limit of J MKO - W2 > 9.984 at 5σ) and refines its position on color-magnitude diagrams. Comparing the new photometry with chemical equilibrium model atmosphere predictions, we demonstrate that W0855 is 2.7σ from models using a cloudless atmosphere and well reproduced by partly cloudy models (50%) containing sulfide and water ice clouds. Non-equilibrium chemistry or non-solar metallicity may change predictions, however using currently available model approaches, this is the first candidate outside our own solar system to have direct evidence for water clouds. This Letter includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

  20. Peaches tree genetic divergence for brown rot reaction

    Directory of Open Access Journals (Sweden)

    Américo Wagner Júnior


    Full Text Available It was evaluated the genetic divergence in peach genotypes for brown rot reaction. It was evaluated 26 and 29 peach genotypes in the 2009/2010 and 2010/2011 production cycle, respectively. The experiment was carried out at the Laboratório de Fitossanidade, da UTFPR - Campus Dois Vizinhos. The experimental design was entirely randomized, considering each peach genotype a treatment, and it was use three replication of nine fruits. The treatment control use three replication of three peach. The fruit epidermis were inoculated individually with 0.15 mL of M. fructicola conidial suspension (1.0 x 10(5 spores mL-1. In the control treatment was sprayed with 0.15 mL of distilled water. The fruits were examined 72 and 120 hours after inoculation, and the incidence and severity disease were evaluated. These results allowed realized study for genetic divergence, used as dissimilarity measure the Generalized Mahalanobis distance. Cluster analysis using Tocher´s optimization method and distances in the plan were applied. There was smallest genetic divergence among peach trees evaluated for brown rot, what can difficult to obtain resistance in the genotypes.

  1. NEOWISE-R observation of the coolest known brown dwarf

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Edward L. [UCLA Astronomy, P.O. Box 951547, Los Angeles, CA 90095-1547 (United States); Mainzer, Amy; Bauer, James; Eisenhardt, Peter R. M. [Jet Propulsion Laboratory, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Davy Kirkpatrick, J.; Masci, Frank; Fajardo-Acosta, Sergio; Gelino, Christopher R.; Beichman, Charles A.; Cutri, Roc [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); Cushing, Michael C. [Department of Physics and Astronomy, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606-3328 (United States); Skrutskie, M. F. [Department of Astronomy, University of Virginia, Charlottesville, VA 22904 (United States); Grav, T., E-mail: [Planetary Science Institute, Tucson, AZ 85719 (United States)


    The Wide-field Infrared Survey Explorer (WISE) spacecraft has been reactivated as NEOWISE-R to characterize and search for near-Earth objects. The brown dwarf WISE J085510.83–071442.5 has now been re-observed by NEOWISE-R, and we confirm the results of Luhman, who found a very low effective temperature (≈250 K), a very high proper motion (8.''1 ± 0.''1 yr{sup –1}), and a large parallax (454 ± 45 mas). The large proper motion has separated the brown dwarf from the background sources that influenced the 2010 WISE data, allowing a measurement of a very red WISE color of W1 – W2 >3.9 mag. A re-analysis of the 2010 WISE astrometry using only the W2 band, combined with the new NEOWISE-R 2014 position, gives an improved parallax of 448 ± 33 mas and a proper motion of 8.''08 ± 0.''05 yr{sup –1}. These are all consistent with values from Luhman.

  2. Hypothalamic regulation of brown adipose tissue thermogenesis and energy homeostasis

    Directory of Open Access Journals (Sweden)

    Wei eZhang


    Full Text Available Obesity and diabetes are increasing at an alarming rate worldwide, but the strategies for the prevention and treatment of these disorders remain inadequate. Brown adipose tissue (BAT is important for cold protection by producing heat using lipids and glucose as metabolic fuels. This thermogenic action causes increased energy expenditure and significant lipid/glucose disposal. In addition, BAT in white adipose tissue (WAT or beige cells have been found and they also exhibit the thermogenic action similar to BAT. These data provide evidence indicating BAT/beige cells as a potential target for combating obesity and diabetes. Recent discoveries of active BAT and beige cells in adult humans have further highlighted this potential. Growing studies have also shown the importance of central nervous system in the control of BAT thermogenesis and WAT browning using animal models. This review is focused on central neural thermoregulation, particularly addressing our current understanding of the importance of hypothalamic neural signaling in the regulation of BAT/beige thermogenesis and energy homeostasis.

  3. Molecular phylogeography of the brown bear (Ursus arctos) in Northeastern Asia based on analyses of complete mitochondrial DNA sequences. (United States)

    Hirata, Daisuke; Mano, Tsutomu; Abramov, Alexei V; Baryshnikov, Gennady F; Kosintsev, Pavel A; Vorobiev, Alexandr A; Raichev, Evgeny G; Tsunoda, Hiroshi; Kaneko, Yayoi; Murata, Koichi; Fukui, Daisuke; Masuda, Ryuichi


    To further elucidate the migration history of the brown bears (Ursus arctos) on Hokkaido Island, Japan, we analyzed the complete mitochondrial DNA (mtDNA) sequences of 35 brown bears from Hokkaido, the southern Kuril Islands (Etorofu and Kunashiri), Sakhalin Island, and the Eurasian Continent (continental Russia, Bulgaria, and Tibet), and those of four polar bears. Based on these sequences, we reconstructed the maternal phylogeny of the brown bear and estimated divergence times to investigate the timing of brown bear migrations, especially in northeastern Eurasia. Our gene tree showed the mtDNA haplotypes of all 73 brown and polar bears to be divided into eight divergent lineages. The brown bear on Hokkaido was divided into three lineages (central, eastern, and southern). The Sakhalin brown bear grouped with eastern European and western Alaskan brown bears. Etorofu and Kunashiri brown bears were closely related to eastern Hokkaido brown bears and could have diverged from the eastern Hokkaido lineage after formation of the channel between Hokkaido and the southern Kuril Islands. Tibetan brown bears diverged early in the eastern lineage. Southern Hokkaido brown bears were closely related to North American brown bears.

  4. Browning in Apples: Exploring the Biochemical Basis of an Easily-Observable Phenotype (United States)

    Deutch, Charles E.


    Many fruits and vegetables undergo browning when they are cut and the tissue is exposed to the air. This is due to the activity of the enzyme polyphenol oxidase (PPO, EC with endogenous substrates. In this laboratory experiment, students prepare slices of different varieties of apples and assess the rate of browning. They make a simple…

  5. Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses (United States)

    Dowal, Louisa; Parameswaran, Pooja; Phat, Sarah; Akella, Syamala; Majumdar, Ishita Deb; Ranjan, Jyoti; Shah, Chahan; Mogre, Saie; Guntur, Kalyani; Thapa, Khampaseuth; Gesta, Stephane; Vishnudas, Vivek K.; Narain, Niven R.


    Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages. White and brown adipocytes were characterized by transcriptional regulation of UCP-1, PGC1α, PGC1β, and CIDEA and their level of IL-6 secretion. The inflammatory profile of PMA-differentiated U937 and THP-1 macrophages, in resting state and after stimulation with LPS/IFN-gamma and IL-4, was assessed by measuring IL-6 secretion and transcriptional regulation of a panel of inflammatory genes after mono- or indirect coculture with white and brown adipocytes. White adipocyte monocultures show increased IL-6 secretion compared to brown adipocytes. White adipocytes cocultured with U937 and THP-1 macrophages induced a greater increase in IL-6 secretion compared to brown adipocytes cocultured with both macrophages. White adipocytes cocultured with macrophages increased inflammatory gene expression in both types. In contrast, macrophages cocultured with brown adipocytes induced downregulation or no alterations in inflammatory gene expression. The effects of adipocytes on macrophages appear to be independent of stimulation state. Brown adipocytes exhibit an intrinsic ability to dampen inflammatory profile of macrophages, while white adipocytes enhance it. These data suggest that brown adipocytes may be less prone to adipose tissue inflammation that is associated with obesity. PMID:28458470

  6. Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses

    Directory of Open Access Journals (Sweden)

    Louisa Dowal


    Full Text Available Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages. White and brown adipocytes were characterized by transcriptional regulation of UCP-1, PGC1α, PGC1β, and CIDEA and their level of IL-6 secretion. The inflammatory profile of PMA-differentiated U937 and THP-1 macrophages, in resting state and after stimulation with LPS/IFN-gamma and IL-4, was assessed by measuring IL-6 secretion and transcriptional regulation of a panel of inflammatory genes after mono- or indirect coculture with white and brown adipocytes. White adipocyte monocultures show increased IL-6 secretion compared to brown adipocytes. White adipocytes cocultured with U937 and THP-1 macrophages induced a greater increase in IL-6 secretion compared to brown adipocytes cocultured with both macrophages. White adipocytes cocultured with macrophages increased inflammatory gene expression in both types. In contrast, macrophages cocultured with brown adipocytes induced downregulation or no alterations in inflammatory gene expression. The effects of adipocytes on macrophages appear to be independent of stimulation state. Brown adipocytes exhibit an intrinsic ability to dampen inflammatory profile of macrophages, while white adipocytes enhance it. These data suggest that brown adipocytes may be less prone to adipose tissue inflammation that is associated with obesity.

  7. 78 FR 52571 - Tennessee Valley Authority, Browns Ferry Nuclear Plant, Unit 1; Applications and Amendments to... (United States)


    ... COMMISSION Tennessee Valley Authority, Browns Ferry Nuclear Plant, Unit 1; Applications and Amendments to... (TVA or the licensee), for operation of the Browns Ferry Nuclear Plant (BFN) Unit 1, located in Alabama... Nuclear Regulatory Commission. Siva P. Lingam, Project Manager, Plant Licensing Branch 2-2, Division of...

  8. 75 FR 13327 - Tennessee Valley Authority; Browns Ferry Nuclear Plant, Units 1, 2, and 3; Exemption (United States)


    ... COMMISSION Tennessee Valley Authority; Browns Ferry Nuclear Plant, Units 1, 2, and 3; Exemption 1.0... DPR-33, DPR-52 and DPR-68, which authorize operation of the Browns Ferry Nuclear Plant, Units 1, 2... industry requests to extend the rule's compliance date for all operating nuclear power plants, but noted...

  9. Copper tolerance of brown-rot fungi : time course of oxalic acid production (United States)

    Frederick Green; Carol A. Clausen


    The increase in the use of non-arsenical copper-based wood preservatives in response to environmental concerns has been accompanied by interest in copper-tolerant decay fungi. Oxalic acid production by brown-rot fungi has been proposed as one mechanism of copper tolerance. Fifteen brown-rot fungi representing the genera Postia, Wolfiporia, Meruliporia, Gloeophyllum,...

  10. Application of Richards\\'s growth model to Brown-headed Parrot ...

    African Journals Online (AJOL)

    Application of Richards\\'s growth model to Brown-headed Parrot Poicephalus cryptoxanthus nestlings. ... Stuart Taylor, Michael R Perrin. Abstract. We generated a generalised growth curve for the Brown-headed Parrot Poicephalus cryptoxanthus. The growth model correlated well with the data from captive-bred chicks and ...

  11. Daytime habitat selection for juvenile parr brown trout (Salmo trutta) in small lowland streams

    DEFF Research Database (Denmark)

    Conallin, J.; Boegh, E.; Olsen, M.


    Physical habitat is important in determining the carrying capacity of juvenile brown trout, and within freshwater management. Summer daytime physical habitat selection for the parr lifestage (7-20 cm) juvenile brown trout (Salmo trutta) was assessed in 6 small lowland streams. Habitat preference ...

  12. Genomic evidence of geographically widespread effect of gene flow from polar bears into brown bears. (United States)

    Cahill, James A; Stirling, Ian; Kistler, Logan; Salamzade, Rauf; Ersmark, Erik; Fulton, Tara L; Stiller, Mathias; Green, Richard E; Shapiro, Beth


    Polar bears are an arctic, marine adapted species that is closely related to brown bears. Genome analyses have shown that polar bears are distinct and genetically homogeneous in comparison to brown bears. However, these analyses have also revealed a remarkable episode of polar bear gene flow into the population of brown bears that colonized the Admiralty, Baranof and Chichagof islands (ABC islands) of Alaska. Here, we present an analysis of data from a large panel of polar bear and brown bear genomes that includes brown bears from the ABC islands, the Alaskan mainland and Europe. Our results provide clear evidence that gene flow between the two species had a geographically wide impact, with polar bear DNA found within the genomes of brown bears living both on the ABC islands and in the Alaskan mainland. Intriguingly, while brown bear genomes contain up to 8.8% polar bear ancestry, polar bear genomes appear to be devoid of brown bear ancestry, suggesting the presence of a barrier to gene flow in that direction. © 2014 The Authors. Molecular Ecology Published by John Wiley & Sons Ltd.

  13. Possible association of congenital Brown syndrome with congenital cranial dysinnervation disorders. (United States)

    Ellis, Forrest J; Jeffery, Amy R; Seidman, David J; Sprague, James B; Coussens, Tracey; Schuller, Jane


    Congenital cranial dysinnervation disorders (CCDDs) are known to arise from abnormal development of individual and multiple cranial nerve nuclei or abnormalities in cranial nerve axonal transport. We report our findings for several patients with Brown syndrome in association with other known abnormalities characteristic of CCDDs. The medical records of patients presenting during a 4-year period with congenital Brown syndrome were retrospectively reviewed. Patients with Brown syndrome confirmed by forced ductions were included in the study if the Brown syndrome was associated with either an abnormal development of the superior oblique muscle or superior oblique paresis, ptosis, Duane syndrome, or other known CCDDs. A total of 9 patients with Brown syndrome were identified. Of these, 3 also demonstrated a contralateral superior oblique palsy; 2, a contralateral Duane syndrome; 1, an ipsilateral congenital ptosis; and 3, a moderate to severely hypoplastic ipsilateral superior oblique muscle. Some patients with congenital Brown syndrome are associated with and possibly in the spectrum of CCDDs. We propose that Brown syndrome may be due to abnormal development of the trochlear nerve, which results in physical changes in the superior oblique muscle-tendon-trochlea complex. This results in a tendon that is either long and lax, absent, or abnormally inserted (ie, superior oblique paresis) or a tendon that is restricted in its movements through the trochlea (Brown syndrome). Copyright © 2012 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.

  14. Fucoxanthin and Its Metabolites in Edible Brown Algae Cultivated in Deep Seawater

    Directory of Open Access Journals (Sweden)

    Kanami Mori


    Full Text Available Abstract: Three metabolites of fucoxanthin were isolated from a brown alga, Scytosiphon lomentaria, and the structure of a new compound was determined by NMR. The content of fucoxanthin, a biologically active carotenoid, in four edible brown algae, cultivated in deep seawater, was studied.

  15. Short communication: Evidence for methylglyoxal-mediated browning of Parmesan cheese during low temperature storage. (United States)

    Divine, R D; Sommer, D; Lopez-Hernandez, A; Rankin, S A


    Brown pigmentation can occasionally form in Parmesan cheese during the ripening process, creating an unappealing appearance and associated off-flavors. The browning reactions proceed at refrigerated temperatures and in the relative absence of reducing sugar, contrary to typical Maillard browning. Residual sugars, lipid oxidation products, byproducts of fermentation, and (or) enzymes may react with primary amines in cheese to form brown pigmentation and concomitantly generate volatile compounds unique to each of these reactions. Determining the volatile profiles provides a means of understanding the potential substrates involved and causative reaction pathways. This work is divided into 2 segments. The first portion characterized the pigmentation and the browning index of Parmesan cheeses with and without extensive browning. The second phase examined the volatile character of the cheeses using gas chromatography-mass spectrometry. Various pyrazines, such as 2,3,5-trimethylpyrazine and 3,5-diethyl-2-methylpyrazine, were found in the brown cheeses but were not present in the white samples. The formation of pyrazines is proposed to result from the spontaneous condensation of aminoacetone. Aminoacetone can be formed by the Strecker degradation of amino acids with methylglyoxal, the latter a byproduct of sugar fermentation. Evidence is provided to support a browning pathway mediated by the production of methylglyoxal in Parmesan cheese. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  16. Brown v. Board at 60: Why Have We Been so Disappointed? What Have We Learned? (United States)

    Rothstein, Richard


    May 17 is the 60th anniversary of "Brown v. Board of Education," the U.S. Supreme Court's 1954 decision that prohibited Southern states from segregating schools by race. The "Brown" decision annihilated the "separate but equal" rule, previously sanctioned by the Supreme Court in 1896, that permitted states and school…

  17. Application of exogenous ethylene inhibits postharvest peel browning of ‘Huangguan’ pear (United States)

    Peel browning disorder has an enormous impact on the exterior quality of ‘Huangguan’ pear whereas the underlying mechanism is still unclear. In this study, the effect of exogenous ethylene on peel browning of pear fruits stored at 0' was evaluated. Results showed that ethylene effectively inhibited ...

  18. Management options for brown shrimp (Crangon crangon) fisheries in the North Sea

    NARCIS (Netherlands)

    Steenbergen, J.; Kooten, van T.; Wolfshaar, van de K.E.; Trapman, B.K.; Reijden, van der K.J.


    Fisheries targeting brown shrimp (Crangon crangon) in the North Sea in European waters are largely unregulated in terms of landings and effort. A license system exists, but this did not prevent the current situation of overcapacity of the shrimp fleet. The governments of the North Sea brown shrimp

  19. Brown tumor of the spine with compression fracture: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Young Woo; Ok, Chul Su [Se Jong Medical Imaging Center, Seoul (Korea, Republic of)


    Brown tumor of bone is a severe form of skeletal complication in patients with hyperparathyroidism. The main sites of involvement are the mandible, sternum ribs, pelvis and femur. Involvement of the spine is less common. We report here a case of brown tumor of the spine that developed in a patient with right parathyroid adenoma.

  20. The Brown University Traumatic Brain Injury Research Consortium and the Norman Prince Neurosciences Institute. (United States)

    Rogg, Jeffrey; Spader, Heather; Wilcox, Bethany J; Ellermeier, Anna; Correira, Steven; Chodobski, Adam; Szmydynger-Chodobska, Joanna; Raukar, Neha; Machan, Jason T; Crisco, Joseph J; LaFrance, W Curt


    This article provides an overview of the Brown University Traumatic Brain Injury Research Consortium (TBIRC) and summarizes the multidisciplinary basic and clinical neuroscience work being conducted by investigators at Brown University and the affiliate hospitals in association with the Norman Prince Neurosciences Institute (NPNI).

  1. Radio-transmitted electromyogram signals as indicators of swimming speed in lake trout and brown trout

    DEFF Research Database (Denmark)

    Thorstad, E.B.; Økland, F.; Koed, Anders


    Swimming speed and average electromyogram (EMG) pulse intervals were highly correlated in individual lake trout Salvelinus namaycush (r(2)=0.52-0.89) and brown trout Salmo trutta (r(2)=0.45-0.96). High correlations were found also for pooled data in both lake trout (r(2)=0.90) and brown trout...

  2. Their Cries Went Up Together: Brown et al. v. Board of Education Then and Now (United States)

    Neal, La Vonne I.; Moore, Alicia L.


    This article speaks to the fragmentary information available about the 12 plaintiffs other than Oliver L. Brown who also were participants in the Brown v. Board of Education case. In particular, it highlights the experiences of Lucinda Todd, the first plaintiff in the case. It uses this case in a discussion of the importance of illuminating…

  3. Fifty Years after Brown: The Benefits and Tradeoffs for African American Educators and Students (United States)

    Lyons, James E.; Chesley, Joanne


    The benefits and tradeoffs for African American professional educators and students resulting from the profound Brown v. Board of Education decision are discussed. Results show that the vast majority of respondents believed that Brown had benefited both African American educators and students.

  4. Understanding the Biology of Thermogenic Fat: Is Browning A New Approach to the Treatment of Obesity? (United States)

    Vargas-Castillo, Ariana; Fuentes-Romero, Rebeca; Rodriguez-Lopez, Leonardo A; Torres, Nimbe; Tovar, Armando R


    Obesity is characterized by an excess of white adipose tissue (WAT). Recent evidence has demonstrated that WAT can change its phenotype to a brown-like adipose tissue known as beige/brite adipose tissue. This transition is characterized by an increase in thermogenic capacity mediated by uncoupling protein 1 (UCP1). This browning process is a potential new target for treating obesity. The aim of this review is to integrate the different mechanisms by which beige/brite adipocytes are formed and to describe the physiological, pharmacological and nutritional inducers that can promote browning. An additional aim is to show evidence of how some of these inducers can be used as potential therapeutic agents against obesity and its comorbidities. This review shows the importance of brown and beige/brite adipose tissue and the mechanisms of their formation. Particularly, the two theories of beige/brite adipocyte origin are discussed: de novo differentiation and transdifferentiation. The gene markers that identify these types of adipocytes and the involvement of microRNAs in the epigenetic regulation of the browning process is also discussed. Additionally, we describe the transcriptional control of UCP1 expression by some of the inducers of browning. Furthermore, we describe in detail how some bioactive dietary compounds can induce browning and their subsequent beneficial health effects. The evidence suggests that browning is a new potential strategy for the treatment of obesity and obesity-associated metabolic disorders. Copyright © 2017 IMSS. Published by Elsevier Inc. All rights reserved.

  5. Brown recluse spider (Loxosceles reclusa) envenomation leading to acute hemolytic anemia in six adolescents


    McDade, Jenny; Aygun, Banu; Ware, Russell E.


    Loxosceles reclusa (brown recluse spider) bites often cause local envenomation reactions, however acute hemolysis from systemic loxoscelism is rare. To highlight this important diagnostic consideration for unexplained hemolysis in areas endemic for brown recluse spiders, we report six adolescents with acute hemolytic anemia from presumed L. reclusa bites.

  6. Brown recluse spider (Loxosceles reclusa) envenomation leading to acute hemolytic anemia in six adolescents. (United States)

    McDade, Jenny; Aygun, Banu; Ware, Russell E


    Loxosceles reclusa (brown recluse spider) bites often cause local envenomation reactions; however, acute hemolysis from systemic loxoscelism is rare. To highlight this important diagnostic consideration for unexplained hemolysis in areas endemic for brown recluse spiders, we report on 6 adolescents with acute hemolytic anemia from presumed L reclusa bites.

  7. The feeding habits of brown hyaenas ( Hyaena brunnea ) on a game ...

    African Journals Online (AJOL)

    We analysed prey remains, particularly hair, in 38 brown hyaena Hyaena brunnea scats from a game ranch in the Limpopo Province, South Africa. The brown hyaenas fed on a wide variety of mammals, supplementing their diet with insects and plant material. Artiodactyls were the most important mammalian food source, ...

  8. Inhibition of tyrosinase-mediated enzymatic browning by sulfite and natural alternatives

    NARCIS (Netherlands)

    Kuijpers, T.F.M.; Vincken, J.P.


    Although sulfite is widely used to counteract enzymatic browning, its mechanism has remained largely unknown. We describe a double inhibitory mechanism of sulfite on enzymatic browning, affecting both the enzymatic oxidation of phenols into o‑quinones, as well as the non‑enzymatic reactions of these

  9. The mechanism of ethanol treatment on inhibiting lettuce enzymatic browning and microbial growth (United States)

    Tissue browning of fresh-cut lettuce greatly affects its quality and consumers’ appreciation. This study investigated the effects of ethanol treatment on enzymatic browning and natural microflora growth of lettuce stem discs. After treated with 20% ethanol for 2 min and then drained by a spinner, le...

  10. Global population divergence and admixture of the brown rat (Rattus norvegicus)

    NARCIS (Netherlands)

    Puckett, Emily E.; Park, Jane; Combs, Matthew; Blum, Michael J.; Bryant, Juliet E.; Caccone, Adalgisa; Costa, Federico; Deinum, Eva E.; Esther, Alexandra; Himsworth, Chelsea G.; Keightley, Peter D.; Ko, Albert; Lundkvist, Åke; McElhinney, Lorraine M.; Morand, Serge; Robins, Judith; Russell, James; Strand, Tanja M.; Suarez, Olga; Yon, Lisa; Munshi-South, Jason


    Native to China and Mongolia, the brown rat (Rattus norvegicus) now enjoys a worldwide distribution. While black rats and the house mouse tracked the regional development of human agricultural settlements, brown rats did not appear in Europe until the 1500s, suggesting their range expansion was a

  11. Scanning electron microscopic observation of the brown tumor of the head of mandible. (United States)

    Tunali, Selcuk; Celik, Hamdi H; Uslu, Sabri S; Aldur, Mustafa M


    Brown tumors are tumor-like, expansile osteolytic lesions of bone which are seen in both primary and secondary hyperparathyroidism. They generally resolve after surgical treatment of the parathyroid adenoma. Here, we report a case of brown tumor of the mandible of a cadaver with its scanning electron microscopic observation and review of literature.

  12. 78 FR 48666 - Browns Valley Irrigation District; Notice of Declaration of Intention and Soliciting Comments... (United States)


    ... Energy Regulatory Commission Browns Valley Irrigation District; Notice of Declaration of Intention and... of Intention b. Docket No: DI13-6-000 c. Date Filed: July 15, 2013 d. Applicant: Browns Valley... Declaration of Intention is filed with the Federal Energy Regulatory Commission, the Federal Power Act...

  13. Pyrolysis of Compositions of Mixtures of Combustible Shales and Brown Coals Deposited in Belarus (United States)

    Lishtvan, I. I.; Dudarchik, V. M.; Kraiko, V. M.; Belova, Yu. V.


    This paper presents the results of investigating the pyrolysis of compositions of mixtures of brown coals and combustible shales in a close-packed and a moving layer and the yield dynamics of the pyrolysis gas and resin. A comparative analysis of the quality of pyrolysis products obtained from combustible shales and brown coal and from their mixtures has been performed.

  14. Effects of high-carbohydrate diets on lipogenesis in rat interscapular brown adipose tissue


    Weaire, P. John; Kanagasabai, Tazeen F.


    Cycloplasmic preparations from brown and white adipose tissues were assayed for three lipogenic enzymes throughout a programme of starvation followed by refeeding on either a normal or a white-bread diet. In the brown adipose tissue of rats fed on a white-bread diet the three enzymes were elevated to levels significantly higher than those in white adipose tissue.

  15. "'Look More Closely,' Said Mum": Mothers in Anthony Browne's Picture Books (United States)

    Joosen, Vanessa


    In this article, Vanessa Joosen explores Anthony Browne's construction of motherhood in four of his picture books that focus on family. She focuses on the use of narratological perspective, visual point of view, and intertextual references to explain how an ideology of motherhood is evoked. While Browne makes use of child narrators and focalizers…

  16. Influence of Didymosphenia geminata blooms on prey composition and associated diet and growth of Brown Trout (United States)

    James, Daniel A.; Chipps, Steven R.


    We compared diet, stomach fullness, condition, and growth of Brown Trout Salmo trutta among streams with or without blooms of the benthic diatom Didymosphenia geminata in the Black Hills, South Dakota. In Rapid Creek, where D. geminata blooms covered ∼30% of the stream bottom, Brown Trout consumed fewer ephemeropterans (6–8% by weight) than individuals from two stream sections that have not had D. geminatablooms (Castle and Spearfish creeks; 13–39% by weight). In contrast, dipterans (primarily Chironomidae) represented a larger percentage of Brown Trout diets from Rapid Creek (D. geminata blooms present; 16–28% dry weight) compared with diets of trout from streams without D. geminata blooms (6–19% dry weight). Diets of small Brown Trout (100–199 mm TL) reflected the invertebrate species composition in benthic stream samples; in Rapid Creek, ephemeropterans were less abundant whereas dipterans were more abundant than in streams without D. geminata blooms. Stomach fullness and condition of Brown Trout from Rapid Creek were generally greater than those of Brown Trout from other populations. Linkages among invertebrate availability, diet composition, and condition of Brown Trout support the hypothesis that changes in invertebrate assemblages associated with D. geminata (i.e., more Chironomidae) could be contributing to high recruitment success for small Brown Trout in Rapid Creek.

  17. Pre-germinated brown rice could enhance maternal mental health and immunity during lactation. (United States)

    Sakamoto, Shigeko; Hayashi, Takashi; Hayashi, Keiko; Murai, Fumie; Hori, Miyo; Kimoto, Koichi; Murakami, Kazuo


    Rice is a dietary staple worldwide, especially pre-germinated brown rice has recently been widely served in Japan because of its abundant nutrition. Relationship between lactation and pre-germinated brown rice has attracted interest in terms of mental health and immunity. To demonstrate that Japanese foods are beneficial for psychosomatic health, the effects of pre-germinated brown rice on the mental status and immunological features during lactation were investigated. Forty-one breast-feeding mothers were recruited, and randomly divided into two groups. One group took pre-germinated brown rice and the other white rice (control) as their staple diet for 2 weeks. The Profile of Mood States (POMS) and salivary amylase activity as psychological indices and secretory IgA (s-IgA) and lactoferrin (LTF) in breast milk as immunological indices were determined before and after dietary intervention, and changes were investigated. In the psychological assessment, the scores of depression, anger-hostility, and fatigue were decreased on POMS analysis in the pre-germinated brown rice diet group, resulting in a significant decrease in total mood disturbance (TMD). The salivary amylase activity measurement suggested that resistance to stress was increased in the pre-germinated brown rice diet group. On the immunological assessment, the s-IgA level was significantly increased in the pre-germinated brown rice diet group. We have shown that pre-germinated brown rice may have beneficial effects on psychosomatic health.

  18. Brown's syndrome with ocular albinism: Case report of a rare presentation and literature review. (United States)

    Nambiar, Soumya; Ramasubramanian, Srikanth; Swaminathan, Meenakshi


    We report a rare case of Brown's syndrome associated with ocular albinism in a 10-year-old boy. This report highlights the importance of further analysis of cases of Brown's syndrome and throws some light on the etiology and association of this rare condition.

  19. Data from: Global population divergence and admixture of the brown rat (Rattus norvegicus)

    NARCIS (Netherlands)

    Puckett, Emily E.; Park, Jane; Combs, Matthew; Blum, Michael J.; Bryant, Juliet E.; Caccone, Adalgisa; Costa, Federico; Deinum, E.E.


    Native to China and Mongolia, the brown rat (Rattus norvegicus) now enjoys a worldwide distribution. While black rats and the house mouse tracked the regional development of human agricultural settlements, brown rats did not appear in Europe until the 1500s, suggesting their range expansion was a

  20. An environmental DNA marker for detecting nonnative brown trout (Salmo trutta) (United States)

    K. J. Carim; T. M. Wilcox; M. Anderson; D. Lawrence; Michael Young; Kevin McKelvey; Michael Schwartz


    Brown trout (Salmo trutta) are widely introduced in western North America where their presence has led to declines of several native species. To assist conservation efforts aimed at early detection and eradication of this species, we developed a quantitative PCR marker to detect the presence of brown trout DNA in environmental samples. The marker strongly...

  1. Fertility and hatchability potentials of ShikaBrown® chickens and ...

    African Journals Online (AJOL)

    Six hundred ShikaBrown® chickens fertile eggs were sourced, incubated and 21 weeks old ShikaBrown® layers were used for studying some external egg quality traits. Data collected were subjected to Analysis of Variance (SAS 9); Univariate was applied to test the effects of age and body weight on external egg quality ...

  2. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation

    DEFF Research Database (Denmark)

    Hansen, Jacob B; Jørgensen, Claus; Petersen, Rasmus K


    Adipocyte precursor cells give raise to two major cell populations with different physiological roles: white and brown adipocytes. Here we demonstrate that the retinoblastoma protein (pRB) regulates white vs. brown adipocyte differentiation. Functional inactivation of pRB in wild-type mouse embryo...... into adipocytes with a gene expression pattern and mitochondria content resembling brown adipose tissue. pRB-deficient MEFs exhibit an increased expression of the Forkhead transcription factor Foxc2 and its target gene cAMP-dependent protein kinase regulatory subunit RIalpha, resulting in increased c......AMP sensitivity. Suppression of cAMP-dependent protein kinase activity in Rb(-/-)MEFs blocked the brown adipocyte-like gene expression pattern without affecting differentiation per se. Immunohistochemical studies revealed that pRB is present in the nuclei of white but not brown adipocyte precursor cells...

  3. In vitro gastric digestion of cooked white and brown rice using a dynamic rat stomach model. (United States)

    Wu, Peng; Deng, Renpan; Wu, Xuee; Wang, Yong; Dong, Zhizhong; Dhital, Sushil; Chen, Xiao Dong


    The changes in physical, rheological and enzyme-digestive behaviours of cooked white and brown rice, with similar amylose content, were investigated using a dynamic in vitro rat stomach (DIVRS) model and a static soaking method. The brown rice had a higher resistance on disintegration and lower gastric emptying rate with 53% of the brown rice particles retained in the stomach at the end compared to 32% for the white rice. Furthermore, the release rate of maltose from the starch hydrolysis was higher in the white rice throughout the digestion suggesting the lower glycemic potency of the brown rice. These differences could be contributed from the rigid bran layer in the brown rice which would inhibit the moisture absorption into rice kernels, limit textural degradation, and generate higher gastric digesta viscosity leading to lower mixing and mass transfer efficiency. This study suggests that the structural difference could affect physiochemical properties during gastric digestion. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Envenomation from the brown recluse spider: review of mechanism and treatment options. (United States)

    Merigian, K S; Blaho, K


    The brown recluse spider in commonly found throughout the midsouth region of the United States. Bites from the brown recluse occur when the spider is trapped in clothing or its nest is otherwise disturbed. The bite may be undetected by the patient until hours or days later when a characteristic lesion develops. Mild reactions to envenomation are usually limited to a lesion only. In some cases, a severe reaction results which can be life-threatening. Although there have been case reports of various pharmacological agents used for the treatment of brown recluse bites, none have been shown to be consistently effective. Therapy for brown recluse bites remains centered around aggressive wound care. Early surgical excision has not been shown to be of benefit and in most cases delays healing. This review focuses on the physiological mechanisms of the brown recluse venom and current treatment options.

  5. Honeys from different floral sources as inhibitors of enzymatic browning in fruit and vegetable homogenates. (United States)

    Chen, L; Mehta, A; Berenbaum, M; Zangerl, A R; Engeseth, N J


    Honeys from different floral sources were evaluated for their antioxidant content and for their ability to inhibit enzymatic browning in fruits and vegetables. Antioxidant contents of honeys vary widely from different floral sources, as do their abilities to protect against enzymatic browning. Polyphenol oxidase (PPO) activity was reduced over a range of approximately 2-45% in fruit and vegetable homogenates, corresponding to a reduction in browning index by 2.5-12 units. Soy honey was particularly effective when compared to clover honey, which had a similar antioxidant content. When compared to commercial inhibitors of browning, honeys were less effective; however, in combination they added to the effectiveness of metabisulfite and ascorbic acid. Honey has great potential to be used as a natural source of antioxidants to reduce the negative effects of PPO browning in fruit and vegetable processing.

  6. Influence of small hydropower plants on brown trout (Salmo trutta L. population in Mislinja River

    Directory of Open Access Journals (Sweden)

    Blaž Cokan


    Full Text Available The brown trout (Salmo trutta L. in the Mislinja River has been endangered for years because of small hydroelectric power plants. To find out how they are affecting the population of the brown trout in the Mislinja River, we conducted a sampling of the brown trout, using a generating set. We measured the length and weight of all caught specimens and analysed the obtained data. The results are presented in this paper, e.g., biomass, estimations of abundance, average weight, average length and number of captured brown trout. We discovered that the population of the brown trout has decreased in all the sections where water has been taken away for small hydroelectric power plants.

  7. Biosynthetic pathway and health benefits of fucoxanthin, an algae-specific xanthophyll in brown seaweeds. (United States)

    Mikami, Koji; Hosokawa, Masashi


    Fucoxanthin is the main carotenoid produced in brown algae as a component of the light-harvesting complex for photosynthesis and photoprotection. In contrast to the complete elucidation of the carotenoid biosynthetic pathways in red and green algae, the biosynthetic pathway of fucoxanthin in brown algae is not fully understood. Recently, two models for the fucoxanthin biosynthetic pathway have been proposed in unicellular diatoms; however, there is no such information for the pathway in brown seaweeds to date. Here, we propose a biosynthetic pathway for fucoxanthin in the brown seaweed, Ectocarpus siliculosus, derived from comparison of carotenogenic genes in its sequenced genome with those in the genomes of two diatoms, Thalassiosira pseudonana and Phaeodactylum tricornutum. Currently, fucoxanthin is receiving attention, due to its potential benefits for human health. Therefore, new knowledge regarding the medical and nutraceutical properties of fucoxanthin from brown seaweeds is also summarized here.

  8. Biosynthetic Pathway and Health Benefits of Fucoxanthin, an Algae-Specific Xanthophyll in Brown Seaweeds

    Directory of Open Access Journals (Sweden)

    Masashi Hosokawa


    Full Text Available Fucoxanthin is the main carotenoid produced in brown algae as a component of the light-harvesting complex for photosynthesis and photoprotection. In contrast to the complete elucidation of the carotenoid biosynthetic pathways in red and green algae, the biosynthetic pathway of fucoxanthin in brown algae is not fully understood. Recently, two models for the fucoxanthin biosynthetic pathway have been proposed in unicellular diatoms; however, there is no such information for the pathway in brown seaweeds to date. Here, we propose a biosynthetic pathway for fucoxanthin in the brown seaweed, Ectocarpus siliculosus, derived from comparison of carotenogenic genes in its sequenced genome with those in the genomes of two diatoms, Thalassiosira pseudonana and Phaeodactylum tricornutum. Currently, fucoxanthin is receiving attention, due to its potential benefits for human health. Therefore, new knowledge regarding the medical and nutraceutical properties of fucoxanthin from brown seaweeds is also summarized here.

  9. Current status of brown bears in the Manasalu Conservation Area, Nepal (United States)

    Aryal, Achyut; Sathyakumar, S.; Schwartz, Charles C.


    Although brown bears (Ursus arctos) are rare in the Himalayan region, populations have been documented in alpine habitats of Pakistan and India. Brown bears were once known to exist in both Nepal and Bhutan, but current information on their numbers and distributions was lacking. We document the presence of brown bears in the Manasalu Conservation Area (MCA) in Nepal using field surveys and interviews with local people. We were able to confirm the existence of a remnant population based on finding bear scat and locations where bears excavated for Himalayan marmots (Marmota himalayana). Based on interviews with local people, it appeared that the presence of brown bears in the area is relatively recent and likely a result of immigration of bears from the Tibetan Autonomous Region. Interviews with local herders also indicated that livestock losses from brown bear predation amounted to approximately 318,000 Nepali rupees (US $4,240) from February 2006 through July 2008.

  10. Application of Exogenous Ethylene Inhibits Postharvest Peel Browning of 'Huangguan' Pear. (United States)

    Ma, Yurong; Yang, Mengnan; Wang, Jingjing; Jiang, Cai-Zhong; Wang, Qingguo


    Peel browning disorder has an enormous impact on the exterior quality of 'Huangguan' pear whereas the underlying mechanism is still unclear. Although different methods have been applied for inhibiting the peel browning of 'Huangguan' pear, there are numerous issues associated with these approaches, such as time cost, efficacy, safety and stability. In this study, to develop a rapid, efficient and safe way to protect 'Huangguan' pear from skin browning, the effect of exogenous ethylene on peel browning of pear fruits stored at 0°C was evaluated. Results showed that ethylene treatments at 0.70-1.28 μL/L significantly decreased the browning rate and browning index from 73.80% and 0.30 to 6.80% and 0.02 after 20 days storage at 0°C, respectively, whereas ethylene treatments at 5 μL/L completely inhibited the occurrence of browning. In addition, ethylene treatments at 5 μL/L decreased the electrolyte leakage and respiration rate, delayed the loss of total phenolic compounds. Furthermore, ethylene (5 μL/L) treatment significantly enhanced the activity of catalase (CAT), ascorbate peroxidase (APX) and superoxide dismutase (SOD) and increased the 1, 1-diphenyl-2-picrylhydrazyl inhibition rate, but inhibited the activity of polyphenol oxidase (PPO) and peroxidase (POD). Our data revealed that ethylene prevented the peel browning through improving antioxidant enzymes (CAT, APX and SOD) activities and reducing PPO activity, electrolyte leakage rate and respiration rate. This study demonstrates that exogenous ethylene application may provide a safe and effective alternative method for controlling browning, and contributes to the understanding of peel browning of 'Huangguan' pear.

  11. Conservation implications of brown hyaena (Parahyaena brunnea population densities and distribution across landscapes in Botswana

    Directory of Open Access Journals (Sweden)

    Christiaan W. Winterbach


    Full Text Available The brown hyaena (Parahyaena brunnea is endemic to southern Africa. The largest population of this near-threatened species occurs in Botswana, but limited data were available to assess distribution and density. Our objectives were to use a stratified approach to collate available data and to collect more data to assess brown hyaena distribution and density across land uses in Botswana. We conducted surveys using track counts, camera traps and questionnaires and collated our results and available data to estimate the brown hyaena population based on the stratification of Botswana for large carnivores. Brown hyaenas occur over 533 050 km² (92% of Botswana. Our density estimates ranged from 0 brown hyaenas/100 km² in strata of northern Botswana to 2.94 (2.16–3.71 brown hyaenas/100 km² in the southern stratum of the Central Kalahari Game Reserve. We made assumptions regarding densities in strata that lacked data, using the best references available. We estimated the brown hyaena population in Botswana as 4642 (3133–5993 animals, with 6.8% of the population in the Northern Conservation Zone, 73.1% in the Southern Conservation Zone, 2.0% in the smaller conservation zones and 18.1% in the agricultural zones. The similar densities of brown hyaenas in the Central Kalahari Game Reserve and the Ghanzi farms highlight the potential of agricultural areas in Botswana to conserve this species. The conservation of brown hyaenas in the agricultural landscape of Botswana is critical for the long-term conservation of the species; these areas provide important links between populations in South Africa, Namibia and Zimbabwe.Conservation implications: Botswana contains the core of the brown hyaena population in southern Africa, and conflict mitigation on agricultural land is crucial to maintaining connectivity among the range countries.

  12. Brown Dwarf Binaries as Tests of Substellar Evolution (United States)

    Martin, Eduardo


    We propose to obtain STIS spectroscopy of two brown dwarf binaries for which dynamical masses are being obtained by monitoring the orbital motion using ground-based telescopes with adaptive optics. The HST/STIS spectra will allow to study the LiI resonance line at 670.8 nm. The lithium depletion of the members of these binaries will be estimated with the aid of synthetic spectra. These observations will be compared to model predictions of lithium depletion as a function of age and mass, and hence will provide an observational test to the theory of substellar objects. Spin-offs will be the measurement of the strength of Halpha emission, an indicator of chromospheric activity in cool atmospheres, and comparing the shape of the optical continuum with model spectra with different dust opacities.

  13. Bok Prize Lecture (shared) The Brown Dwarf Radial Velocity Survey (United States)

    Charbonneau, Dave


    The swarm of nearby brown dwarfs and very low mass stars is an attractive sample for radial velocity monitoring. Such work is best conducted with an echelle spectrograph operating at infrared wavelengths where these objects(i) are most luminous, (ii) have a forest of molecular features, providing an excellent velocity metric, and {iii) are superimposed on the telluric spectrum, which yields the requisite wavelength calibration. I will present first results from such a survey, with a precision sufficient to detect Jupiter-mass planets with orbital periods of less than a year. Should such systems be uncovered, the planets would be amenable to direct study, due to system proximity, and the favorable contrast ratio between the planet and parent object.

  14. Positive relationship between citrus leaf miner and alternaria brown spot

    Directory of Open Access Journals (Sweden)

    Fernando Alves de Azevedo


    Full Text Available Alternaria brown spot, or ABS (Alternaria alternata, is the most prevalent fungal disease of tangerines in the world. Field observations have revealed ABS lesions on leaves wounded by the citrus leaf miner (CLM. Thus, the objective of this study was to assess the relationship between CLM and ABS. Leaves from young Murcott tangor plants and detached leaves from 16 different varieties of tangerines with and without lesions caused by CLM were inoculated with A. alternata. The symptoms of the plants were subsequently quantified by counting the number of lesions, and the lesion area was estimated using a diagrammatic scale. The presence of CLM damage aggravates the severity of Alternaria alternata fungus infections in susceptible tangerine varieties.

  15. High efficiency Lifter based on the Biefeld-Brown effect

    Directory of Open Access Journals (Sweden)

    Moshe Einat


    Full Text Available The Biefeld-Brown is a fascinating effect with which levitation can be reached without moving or rotating elements. Static voltage is applied between asymmetric electrodes and a force towards the small electrode is generated. This effect is studied experimentally in this paper. Using this effect a set of experiments is conducted trying to clarify the relation of the model geometry to the induced force. The results show clear relations of the generated force to the model structure and dimensions. As the asymmetry is stronger, the force is stronger. According to the experimental results, a set of preferred parameters is given to strength the effect. Choosing the geometrical properties properly led to improvement of factor ∼9 in the generated force and efficiency. Nevertheless, some results provides contradictions to earlier models of electrohydrodynamicmic (EHD describing the effect and reveal unresolved questions regarding this effect.

  16. Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK (United States)

    Martínez de Morentin, Pablo B.; González-García, Ismael; Martins, Luís; Lage, Ricardo; Fernández-Mallo, Diana; Martínez-Sánchez, Noelia; Ruíz-Pino, Francisco; Liu, Ji; Morgan, Donald A.; Pinilla, Leonor; Gallego, Rosalía; Saha, Asish K.; Kalsbeek, Andries; Fliers, Eric; Bisschop, Peter H.; Diéguez, Carlos; Nogueiras, Rubén; Rahmouni, Kamal; Tena-Sempere, Manuel; López, Miguel


    Summary Estrogens play a major role in the modulation of energy balance through central and peripheral actions. Here, we demonstrate that central action of estradiol (E2) inhibits AMP-activated protein kinase (AMPK) through estrogen receptor alpha (ERα) selectively in the ventromedial nucleus of the hypothalamus (VMH), leading to activation of thermogenesis in brown adipose tissue (BAT) through the sympathetic nervous system (SNS) in a feeding-independent manner. Genetic activation of AMPK in the VMH prevented E2-induced increase in BAT-mediated thermogenesis and weight loss. Notably, fluctuations in E2 levels during estrous cycle also modulate this integrated physiological network. Together, these findings demonstrate that E2 regulation of the VMH AMPK-SNS-BAT axis is an important determinant of energy balance and suggest that dysregulation in this axis may account for the common changes in energy homeostasis and obesity linked to dysfunction of the female gonadal axis. PMID:24856932

  17. Fucoidans from brown alga Fucus evanescens: structure and biological activity

    Directory of Open Access Journals (Sweden)

    Roza Menshova


    Full Text Available Brown alga Fucus evanescens, widespread in the Far Eastern seas of Russia, is valuable source of sulfated polysaccharides – fucoidans with beneficial biological activities. The most homogenous fraction of fucoidan from F. evanescens was shown to be molecule containing linear main chain of alternating 2-sulfated 1,3- and 1,4-linked α-L-fucose residues. Few sulfate groups were found in position 4 of some 1,3-linked fucose residues. Acetyl groups occupied free C-3 of 1,4-linked residues and/or the C-4 of 1,3-linked fucose residues. Enzymatic hydrolysis, mild acid hydrolysis and autohydrolysis of native fucoidan were used for elucidation of the fine structural characteristics of fucoidan from F. evanescens. The aim of this review to summarize published data on biological activities of fucoidan from F. evanescens: antiviral, anticoagulant, thrombolytic, hepatoprotective, immunomodulatory, anticancer, and their practical application.

  18. Resonancias Vocales y Memoria Sonora en Helen Brown

    Directory of Open Access Journals (Sweden)

    Andrés Grumann Sölter


    Full Text Available El artículo se concentra en indagar aspectos referidos a la intensificación de los usos de la voz y la sonorización musical que proponen Trinidad Piriz y Daniel Marabolí en Helen Brown (2013. Dando cuenta de un marco teórico que cuestiona la dimensión referencial con la que se analiza frecuentemente al teatro y proponiendo una aproximación fenomenológica que dé cuenta de la materialidad performativa que insta a intensificar las resonancias de la voz y la capacidad audible del sonido, el escrito analiza dos escenas o tracks en los que la memoria hecha cuerpo compromete de un modo particular a los espectadores que participan de la performance escénica.

  19. Pharmacognostical study and phytochemical evaluation of brown seaweed Sargassum wightii

    Directory of Open Access Journals (Sweden)

    Jeyaraman Amutha Iswarya Devi


    Full Text Available Objective: To explore the pharmacognostical and phytochemical properties of Sargassum wightii. Methods: The qualitative microscopy, phytochemical screening, physicochemical evaluation and fluorescence analysis of the plant were carried out according to the standard procedure recommended in the WHO guidelines. Results: Macroscopic study showed that plants were dark brown, 20-30 cm in height, leaves were 5-8 cm length, shape: linear to ovate, apex: midrib in conspicuous and having the entire, serrate margin. Microscopic evaluation of the transverse section of the leaf, stem, air bladder, receptacles showed the presence of epidermis layer followed by thick cuticle, conducting strand, mesophyll and possessed antheridia or oogonia at the swollen terminal portions. The different extracts of Sargassum wightii showed the presence of steroids, alkaloids, phenolic compounds, saponins and flavonoids with varied degree. Conclusions: Various pharmacognostical parameters evaluated in this study help in the identification and standardization of the of the seaweed Sargassum wightii

  20. Outflows from low mass young stars and brown dwarfs (United States)

    Ray, T. P.

    The phenomenon of jets from young stars has been known for over two decades. In most cases the jet is generated either by an embedded (IRAS Class I) low mass star or its more evolved, optically visible counterpart (a classical T Tauri star). In the case of the latter the flow can be traced optically right back to the star although its apparent length may be small in angular terms (typically a few arcseconds). For this reason such jets are sometimes referred to as ``micro-jets''. It is argued that brown dwarfs (BDs) outflows, when observed will almost certainly look like scaled-down versions of the micro-jet phenomenon observed in classical T Tauri stars. Not only then will we need large telescopes to detect such flows but it may also be necessary to employ special techniques, like spectro-astrometry, to resolve them.

  1. Evaluation of conservation-oriented management on grayish brown soil

    Directory of Open Access Journals (Sweden)

    Consuelo E. Hernández Rodríguez


    Full Text Available Conservation and improvement actions were taken to ensure the soil preservation in agricultural areas affected by erosion on a grayish brown soil of Sarduy farm in Cumanayagua, Cuba. The technology that was used included strip-till, crop rotation, live and/or dead barriers, channel terraces, contour farming and the addition of organic matter and biofertilizers. The implementation of the soil conservation-oriented management had an influence on the yield increase of 10.6% - 20.2%, on the decrease of the erosive processes with a retention of soils to 13.33 t.ha -1, on maintaining the soil pH and on the increment of the assimilable P2O5 contents and soil organic matter.

  2. Enzymatic saccharification of brown seaweed for production of fermentable sugars. (United States)

    Sharma, Sandeep; Horn, Svein Jarle


    This study shows that high drying temperatures negatively affect the enzymatic saccharification yield of the brown seaweed Saccharina latissima. The optimal drying temperature of the seaweed in terms of enzymatic sugar release was found to be 30°C. The enzymatic saccharification process was optimized by investigating factors such as kinetics of sugar release, enzyme dose, solid loading and different blend ratios of cellulases and an alginate lyase. It was found that the seaweed biomass could be efficiently hydrolysed to fermentable sugars using a commercial cellulase cocktail. The inclusion of a mono-component alginate lyase was shown to improve the performance of the enzyme blend, in particular at high solid loadings. At 25% dry matter loading a combined glucose and mannitol concentration of 74g/L was achieved. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Trap design for the brown recluse spider, Loxosceles reclusa. (United States)

    Parks, Jennifer; Stoecker, William V; Paige, Robert L


    While there are limited options for chemical-free Arachnid pest control, glue-traps are one suitable alternative to pesticides. The effectiveness of several three-dimensional glue-trap shapes for trapping the brown recluse spider, Loxosceles reclusa Gertsch and Mulaik (Araneae: Sicariidae), was investigated using four novel glue-trap shape designs, which were compared to an existing design currently on the market. These four novel and one standard shape designs were tested using pairwise comparisons. The most preferred trap design was a flat glue-trap with no covering. Although this type of trap was most efficient for capturing L. reclusa, it can pose risks in homes with children and pets for obvious reasons. Among the traps with coverings, the vertical strut trap was most preferred by the spiders, and should perhaps be the trap of choice for homeowners with children and pets.

  4. Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

    Directory of Open Access Journals (Sweden)

    Delphine Duteil


    Full Text Available Previous work indicated that lysine-specific demethylase 1 (Lsd1 can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT and find that BAT-selective Lsd1 ablation induces a shift from oxidative to glycolytic metabolism. This shift is associated with downregulation of BAT-specific and upregulation of white adipose tissue (WAT-selective gene expression. This results in the accumulation of di- and triacylglycerides and culminates in a profound whitening of BAT in aged Lsd1-deficient mice. Further studies show that Lsd1 maintains BAT properties via a dual role. It activates BAT-selective gene expression in concert with the transcription factor Nrf1 and represses WAT-selective genes through recruitment of the CoREST complex. In conclusion, our data uncover Lsd1 as a key regulator of gene expression and metabolic function in BAT.

  5. Seasonal variations of antioxidants in the brown seaweed Saccharina latissima

    DEFF Research Database (Denmark)

    Sørensen, Ann-Dorit Moltke; Safafar, Hamed; Pedersen, Anja

    Mainly the brown seaweeds are known for their high antioxidative capacity within the specific compounds such as phlorotannins, polyphenols, flavonoids, pigments, and these natural antioxidants are of high industrial interest. Previous studies have shown large seasonal variations in biomass...... composition. The aim of this study was to see if there was a seasonal variation in the antioxidant content of sugar kelp (Saccharina latissima), compare two cultivation sites, REF and IMTA, and test different solvents applied for extractions, methanol or ethyl acetate. Rope cultivated sugar kelp were sampled...... solvents with different polarities were applied. Methanol was generally a better solvent for extracting the more polar compounds i.e. phenolics, whereas ethyl acetate tended more efficient for flavonoid extraction. There was no significant variation in the TAC between the two cultivation sites, ranging...


    Directory of Open Access Journals (Sweden)

    Rosana Gonçalves Pires Matias1


    Full Text Available The browning of litchi pericarp (Litchi chinensis Sonn. occurs rapidly after harvest, limiting the marketing period of the fruits. The objective of this study was to evaluate the effect of hot water treatments in preventing browning of the pericarp and the maintenance of postharvest quality of litchi fruit. Fruits of litchi cv. Bengal uniformly red pericarp were submitted to immersion in water at tree temperature (45, 50 and 55°C x five soaking times (0, 4, 8, 12 and 16 minutes in a completely randomized design with tree replications and five fruit per replicate. After drying, the fruits were packed in polystyrene trays, covered with plastic wrap with 12 mm thick and stored in the lab benches at room temperature (19.0 ± 2.4°C and 75 ± 5% RH to simulate the exposure conditions at supermarket counters. Every two days, during eight days, were evaluated the weight loss, color of the pericarp, soluble solids, titratable acidity of the pulp and ascorbic acid content of the pericarp and pulp. It was observed that the weight loss was higher in fruits that were not subjected to hydrothermal treatment. Fruits subjected to 50°C during 16 minutes and 55°C in all immersion times were evaluated only until the 4th day, thereafter, these fruits are not suitable for commercialization. Immersion at 45°C during four minutes was the most effective in maintaining the red color of the pericarp and did not affect the quality measured during the experimental period.

  7. Browning in desert boundaries in Asia in recent decades (United States)

    Jeong, Su-Jong; Ho, Chang-Hoi; Brown, Molly E.; Kug, Jong-Seong; Piao, Shilong


    In this study, the changes in desert boundaries in Asia (Gobi, Karakum, Lut, Taklimakan, and Thar deserts) during the growing season (April-October) in the years 1982-2008 were investigated by analyzing the normalized difference vegetation index (NDVI), precipitation, and temperature. In the desert boundary regions, the domain mean NDVI values increased by 7.2% per decade in 1982-1998 but decreased by 6.8% per decade thereafter. Accordingly, the bare soil areas (or nonvegetated areas) of the inside of the desert boundaries contracted by 9.8% per decade in the 1990s and expanded by 8.7% per decade in the 2000s. It is noted that the five deserts experience nearly simultaneous NDVI changes although they cover a very diverse area of Asia. In contrast, changes in temperature and precipitation in the deserts show rather diverse results. In desert boundaries located along 40°N (Gobi, Taklimakan, and Karakum), the decadal changes in vegetation greenness were mainly related to regional climate during the entire analysis period. Precipitation increased in the 1990s, providing favorable conditions for vegetation growth (i.e., greening), but precipitation reduced (19 mm per decade) and warming intensified (0.7°C per decade) in the 2000s, causing less moisture to be available for vegetation growth (i.e., browning). In desert boundaries below 40°N (Lut and Thar), although an increase in precipitation (8 mm per decade) led to greening in the 1990s, local changes in precipitation and temperature did not necessarily cause browning in the 2000s. Observed multidecadal changes in vegetation greenness in the present study suggest that under significant global and/or regional warming, changes in moisture availability for vegetation growth in desert boundaries are an important factor when understanding decadal changes in areas vulnerable to desertification over Asia.

  8. Benchmark Transiting Brown Dwarf LHS 6343 C: Spitzer Secondary Eclipse Observations Yield Brightness Temperature and Mid-T Spectral Class

    NARCIS (Netherlands)

    Montet, B.T.; Johnson, J.A.; Fortney, J.J.; Desert, J.-M.


    There are no field brown dwarf analogs with measured masses, radii, and luminosities, precluding our ability to connect the population of transiting brown dwarfs with measurable masses and radii and field brown dwarfs with measurable luminosities and atmospheric properties. LHS 6343 C, a weakly

  9. Síndrome de Brown: A propósito de 12 casos Brown's syndrome: Apropos of 12 cases

    Directory of Open Access Journals (Sweden)

    Alina Pedroso Llanes


    Full Text Available Se realizó un estudio descriptivo retrospectivo de 12 pacientes con diagnóstico de síndrome de Brown, que asistieron a la Consulta de Oftalmología Pediátrica y Estrabismo del Hospital Oftalmológico Docente "Ramón Pando Ferrer" desde enero del 1999 a enero de 2000 con los objetivos de precisar la frecuencia del ojo afectado y el grado de severidad del síndrome, identificar los síntomas presentes que motivaron la consulta, determinar los criterios que decidieron la intervención quirúrgica y describir las desviaciones horizontales y verticales asociadas. En la muestra estudiada el 50 % de los pacientes tenían afectación del ojo derecho, el 70 % de los casos presentaban un estadio ligero de la enfermedad, la limitación de la elevación en aducción estuvo presente en el 100 % de los casos, el 30 % de los pacientes tuvieron criterio quirúrgico y el 90 % presentaban desviaciones asociadasA descriptive retrospective study was conducted among 12 patients that were diagnosed Brown's syndrome and who were seen at the Pediatric Ophthalmology and Strabismus Office of "Ramón Pando Ferrer" Ophthalmological Teaching Hospital from January 1999 to January 2000 in order to determine the frequency of the affected eye and the severity degree, to identify the symptoms that motivated the visit, to determine the criteria that decided the surgical procedure and to describe the associated horizontal and vertical deviations. In the studied sample, 50 % of the patients had the right eye affected and 70 % of the cases presented a mild state of the disease. The limitation of the elevation in abduction was present in 100 % of the cases, 30 % of the cases had surgical criterion and 90 % presented associated deviations

  10. 50 years of brown dwarfs from prediction to discovery to forefront of research

    CERN Document Server


    The years 2012/2013 mark the 50th anniversary of the theoretical prediction that Brown Dwarfs, i.e. degenerate objects which are just not massive enough to sustain stable hydrogen fusion, exist. Some 20 years after their discovery, how Brown Dwarfs form is still one of the main open questions in the theory of star formation. In this volume, the pioneers of Brown Dwarf research review the history of the theoretical prediction and the subsequent discovery of Brown Dwarfs. After an introduction, written by Viki Joergens, reviewing Shiv Kumar's theoretical prediction of the existence of brown dwarfs, Takenori Nakano reviews his and Hayashi's calculation of the Hydrogen Burning Minimum Mass. Both predictions happened in the early 1960s. Jill Tarter then writes on the introduction of the term 'Brown Dwarf', before Ben Oppenheimer, Rafael Rebolo and Gibor Basri describe their first discovery of Brown Dwarfs in the 1990s. Lastly, Michael Cushing and Isabelle Baraffe describe the development of the field to the curren...

  11. Black widow spider and brown recluse spider bites in Texas from 1998 through 2002. (United States)

    Forrester, Mathias B; Stanley, Sharilyn K


    Black widow spiders and brown recluse spiders are of medical importance to humans in the US. However, these spiders differ in their habits, habitat, and the clinical effects and treatment of their bite. This study used data from human exposure calls to poison centers in Texas to compare the epidemioloy of bites from these 2 spiders. During 1998-2002, 760 black widow spider bites and 1,369 brown recluse spider bites were reported. Black widow spider bite penetrance demonstrated no secular trend during this time period while the penetrance of brown recluse spider bites increased. A higher percentage of black widow spider bites occurred among males, while a higher proportion of brown recluse spider bites were reported for females. Black widow spider bites most frequently had mild outcomes while brown recluse spider bites most often had moderate outcomes. The majority of reported bites for both types of spider occurred at the patient's own residence, although the percentage was lower for black widow spiders. Seasonal trends were noted for both black widow and brown recluse spiders. The highest penetrance of black widow spider bites was observed in western Texas while the highest penetrance of brown recluse spider bites was observed in central Texas. This information is useful for identifying those populations at greatest risk for the respective spider bites.

  12. An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice. (United States)

    Miao, Yi-Fei; Su, Wen; Dai, Yu-Bing; Wu, Wan-Fu; Huang, Bo; Barros, Rodrigo P A; Nguyen, Hao; Maneix, Laure; Guan, You-Fei; Warner, Margaret; Gustafsson, Jan-Åke


    Estrogen, via estrogen receptor alpha (ERα), exerts several beneficial effects on metabolism and energy homeostasis by controlling size, enzymatic activity and hormonal content of adipose tissue. The actions of estrogen on sympathetic ganglia, which are key players in the browning process, are less well known. In the present study we show that ERβ influences browning of subcutaneous adipose tissue (SAT) via its actions both on sympathetic ganglia and on the SAT itself. A 3-day-treatment with a selective ERβ agonist, LY3201, induced browning of SAT in 1-year-old obese WT and ERα(-/-) female mice. Browning was associated with increased expression of ERβ in the nuclei of neurons in the sympathetic ganglia, increase in tyrosine hydroxylase in both nerve terminals in the SAT and sympathetic ganglia neurons and an increase of β3-adrenoceptor in the SAT. LY3201 had no effect on browning in young female or male mice. In the case of young females browning was already maximal while in males there was very little expression of ERβ in the SAT and very little expression of the β3-adrenoceptor. The increase in both sympathetic tone and responsiveness of adipocytes to catecholamines reveals a novel role for ERβ in controlling browning of adipose tissue.

  13. Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats.

    Directory of Open Access Journals (Sweden)

    Clémence Blouet

    Full Text Available Previous evidence indicates that duodenal lipid sensing engages gut-brain neurocircuits to determine food intake and hepatic glucose production, but a potential role for gut-brain communication in the control of energy expenditure remains to be determined. Here, we tested the hypothesis that duodenal lipid sensing activates a gut-brain-brown adipose tissue neuraxis to regulate thermogenesis. We demonstrate that direct administration of lipids into the duodenum increases brown fat temperature. Co-infusion of the local anesthetic tetracaine with duodenal lipids abolished the lipid-induced increase in brown fat temperature. Systemic administration of the CCKA receptor antagonist devazepide blocked the ability of duodenal lipids to increase brown fat thermogenesis. Parenchymal administration of the N-methyl-d-aspartate receptor blocker MK-801 directly into the caudomedial nucleus of the solitary tract also abolished duodenal lipid-induced activation of brown fat thermogenesis. These findings establish that duodenal lipid sensing activates a gut-brain-brown fat axis to determine brown fat temperature, and thereby reveal a previously unappreciated pathway that regulates thermogenesis.

  14. Seasonal food habits of brown bear (Ursus arctos syriacus Linnaeus, 1758 in Cenral Alborz Protected Area

    Directory of Open Access Journals (Sweden)

    Bagher Nezami Balouchi


    Full Text Available Mountains of Central Alborz Protected Area hold a big population of brown bear, the largest varnivore species in Iran. Understanding food habits is crucial to understanding the ecology of the species. Diet influences many ecological and life-history traits, such as spatial distribution, social and foraging behavior, body mass and reproduction. Therefore, during Jun 2006 to May 2007 we had a comprehensive study on brown bear food habits, as the largest omnivorous of the country in Central Alborz Protected Area. Our investigation showed that plant materials composed the main proportion of food items of the brown bears in the spring until mid-summer. Insects, especially ants were predominantly eaten in the first half of summer. As approaching to hibernation period in late autumn, fruits played the main role of bear food items having high fat content. We never witnessed bear attack on wild herbivores. Furthermore, we never found remains of wild herbivores except a few livestock remains in brown bear scats during our survey period. Accordingly, we concluded that brown bears were almost herbivorous in the Central Alborz Protected Area. We never found any bear scats or fresh signs in three consecutive years, between first of December until mid of March. Also, no direct sighting of brown bear was reported to us by local people and game keepers within the mentioned period. Accordingly, it can be concluded that the brown bears hibernate for a period of 3-3.5 months in winter in the Central Alborz Protected Area.

  15. Population Genomics Reveals Speciation and Introgression between Brown Norway Rats and Their Sibling Species. (United States)

    Teng, Huajing; Zhang, Yaohua; Shi, Chengmin; Mao, Fengbiao; Cai, Wanshi; Lu, Liang; Zhao, Fangqing; Sun, Zhongsheng; Zhang, Jianxu


    Murine rodents are excellent models for study of adaptive radiations and speciation. Brown Norway rats (Rattus norvegicus) are successful global colonizers and the contributions of their domesticated laboratory strains to biomedical research are well established. To identify nucleotide-based speciation timing of the rat and genomic information contributing to its colonization capabilities, we analyzed 51 whole-genome sequences of wild-derived Brown Norway rats and their sibling species, R. nitidus, and identified over 20 million genetic variants in the wild Brown Norway rats that were absent in the laboratory strains, which substantially expand the reservoir of rat genetic diversity. We showed that divergence of the rat and its siblings coincided with drastic climatic changes that occurred during the Middle Pleistocene. Further, we revealed that there was a geographically widespread influx of genes between Brown Norway rats and the sibling species following the divergence, resulting in numerous introgressed regions in the genomes of admixed Brown Norway rats. Intriguing, genes related to chemical communications among these introgressed regions appeared to contribute to the population-specific adaptations of the admixed Brown Norway rats. Our data reveals evolutionary history of the Brown Norway rat, and offers new insights into the role of climatic changes in speciation of animals and the effect of interspecies introgression on animal adaptation. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  16. Transcriptome and biochemical analyses revealed a detailed proanthocyanidin biosynthesis pathway in brown cotton fiber.

    Directory of Open Access Journals (Sweden)

    Yue-Hua Xiao

    Full Text Available Brown cotton fiber is the major raw material for colored cotton industry. Previous studies have showed that the brown pigments in cotton fiber belong to proanthocyanidins (PAs. To clarify the details of PA biosynthesis pathway in brown cotton fiber, gene expression profiles in developing brown and white fibers were compared via digital gene expression profiling and qRT-PCR. Compared to white cotton fiber, all steps from phenylalanine to PA monomers (flavan-3-ols were significantly up-regulated in brown fiber. Liquid chromatography mass spectrometry analyses showed that most of free flavan-3-ols in brown fiber were in 2, 3-trans form (gallocatechin and catechin, and the main units of polymeric PAs were trihydroxylated on B ring. Consistent with monomeric composition, the transcript levels of flavonoid 3', 5'-hydroxylase and leucoanthocyanidin reductase in cotton fiber were much higher than their competing enzymes acting on the same substrates (dihydroflavonol 4-reductase and anthocyanidin synthase, respectively. Taken together, our data revealed a detailed PA biosynthesis pathway wholly activated in brown cotton fiber, and demonstrated that flavonoid 3', 5'-hydroxylase and leucoanthocyanidin reductase represented the primary flow of PA biosynthesis in cotton fiber.

  17. Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes. (United States)

    Lee, Sang Gil; Parks, John S; Kang, Hye Won


    Adipocyte browning is a promising strategy for obesity prevention. Using onion-peel-derived extracts and their bioactive compounds, we demonstrate that onion peel, a by-product of onion, can change the characteristics of white adipocytes to those of brown-like adipocytes in the white adipose tissue of mice and 3T3-L1 cells. The expression of the following brown adipose tissue-specific genes was increased in the retroperitoneal and subcutaneous adipose tissues of 0.5% onion-peel-extract-fed mice: PR domain-containing 16, peroxisome proliferator-activated receptor gamma coactivator 1α, uncoupling protein 1, fibroblast growth factor 21 and cell death-inducing DFFA-like effector. In 3T3-L1 adipocytes, onion peel extract induced the expression of brown adipose tissue-specific genes and increased the expression of carnitine palmitoyltransferase 1α. This effect was supported by decreased lipid levels and multiple small-sized lipid droplets. The ethyl acetate fraction of the onion peel extract that contained the highest proportion of hydrophobic molecules showed the same browning effect in 3T3-L1 adipocytes. A high-performance liquid chromatography analysis further identified quercetin as a functional compound in the browning effect of onion peel. The quercetin-associated browning effect was mediated in part by the activation of AMP-activated protein kinase. In summary, our study provides the first demonstration of the browning effects of onion peel and quercetin using both animal and cell models. This result indicates that onion peel has the potential to remodel the characteristics of white adipocytes to those of brown-like adipocytes. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Chronic hyperinsulinemia reduces insulin sensitivity and metabolic functions of brown adipocyte. (United States)

    Rajan, Sujith; Shankar, Kripa; Beg, Muheeb; Varshney, Salil; Gupta, Abhishek; Srivastava, Ankita; Kumar, Durgesh; Mishra, Raj K; Hussain, Zakir; Gayen, Jiaur R; Gaikwad, Anil N


    The growing pandemics of diabetes have become a real threat to world economy. Hyperinsulinemia and insulin resistance are closely associated with the pathophysiology of type 2 diabetes. In pretext of brown adipocytes being considered as the therapeutic strategy for the treatment of obesity and insulin resistance, we have tried to understand the effect of hyperinsulinemia on brown adipocyte function. We here with for the first time report that hyperinsulinemia-induced insulin resistance in brown adipocyte is also accompanied with reduced insulin sensitivity and brown adipocyte characteristics. CI treatment decreased expression of brown adipocyte-specific markers (such as PRDM16, PGC1α, and UCP1) and mitochondrial content as well as activity. CI-treated brown adipocytes showed drastic decrease in oxygen consumption rate (OCR) and spare respiratory capacity. Morphological study indicates increased accumulation of lipid droplets in CI-treated brown adipocytes. We have further validated these findings in vivo in C57BL/6 mice implanted with mini-osmotic insulin pump for 8weeks. CI treatment in mice leads to increased body weight gain, fat mass and impaired glucose intolerance with reduced energy expenditure and insulin sensitivity. CI-treated mice showed decreased BAT characteristics and function. We also observed increased inflammation and ER stress markers in BAT of CI-treated animals. The above results conclude that hyperinsulinemia has deleterious effect on brown adipocyte function, making it susceptible to insulin resistance. Thus, the above findings have greater implication in designing approaches for the treatment of insulin resistance and diabetes via recruitment of brown adipocytes. © 2016 Society for Endocrinology.

  19. Genome-wide transcriptome and expression profile analysis of Phalaenopsis during explant browning.

    Directory of Open Access Journals (Sweden)

    Chuanjun Xu

    Full Text Available Explant browning presents a major problem for in vitro culture, and can lead to the death of the explant and failure of regeneration. Considerable work has examined the physiological mechanisms underlying Phalaenopsis leaf explant browning, but the molecular mechanisms of browning remain elusive. In this study, we used whole genome RNA sequencing to examine Phalaenopsis leaf explant browning at genome-wide level.We first used Illumina high-throughput technology to sequence the transcriptome of Phalaenopsis and then performed de novo transcriptome assembly. We assembled 79,434,350 clean reads into 31,708 isogenes and generated 26,565 annotated unigenes. We assigned Gene Ontology (GO terms, Kyoto Encyclopedia of Genes and Genomes (KEGG annotations, and potential Pfam domains to each transcript. Using the transcriptome data as a reference, we next analyzed the differential gene expression of explants cultured for 0, 3, and 6 d, respectively. We then identified differentially expressed genes (DEGs before and after Phalaenopsis explant browning. We also performed GO, KEGG functional enrichment and Pfam analysis of all DEGs. Finally, we selected 11 genes for quantitative real-time PCR (qPCR analysis to confirm the expression profile analysis.Here, we report the first comprehensive analysis of transcriptome and expression profiles during Phalaenopsis explant browning. Our results suggest that Phalaenopsis explant browning may be due in part to gene expression changes that affect the secondary metabolism, such as: phenylpropanoid pathway and flavonoid biosynthesis. Genes involved in photosynthesis and ATPase activity have been found to be changed at transcription level; these changes may perturb energy metabolism and thus lead to the decay of plant cells and tissues. This study provides comprehensive gene expression data for Phalaenopsis browning. Our data constitute an important resource for further functional studies to prevent explant browning.

  20. Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment

    DEFF Research Database (Denmark)

    Murholm, Maria; Dixen, Karen; Qvortrup, Klaus


    ) and a remarkably higher mitochondrial abundance in brown adipocytes. METHODOLOGY/PRINCIPAL FINDINGS: Here we report a comprehensive characterisation of gene expression linked to mitochondrial DNA replication, transcription and function during white and brown fat cell differentiation in vitro as well as in white...... precursor cells promotes mitochondrial DNA replication, and that silencing of PRDM16 expression during brown fat cell differentiation blunts mitochondrial biogenesis and expression of brown fat cell markers. CONCLUSIONS/SIGNIFICANCE: Using both in vitro and in vivo model systems of white and brown fat cell...