The labour ward analgesic service at King Edward VIII Hospital ...

African Journals Online (AJOL)

The labour ward analgesic service at King Edward VIII. Hospital, Durban. D. A. ROCKE, C. C. ROUT, H. D. RUSSELL, S. SINGH. Abstract The provision of analgesic services to the labour ward at King Edward VIII Hospital was studied during a I-week period. Of249 patients, 113 (45%) received no analgesia whatsoever.

Thermoelectrical properties of the compounds ScM{sup VIII}Sb and YM{sup VIII}Sb (M{sup VIII} = Ni, Pd, Pt)

Energy Technology Data Exchange (ETDEWEB)

Oestreich, J; Probst, U; Richardt, F; Bucher, E [University of Konstanz, PO Box X916, D-78457 Konstanz (Germany)

2003-02-05

The research into new materials with good thermoelectric properties has revealed new compounds consisting of metallic elements (Bando Y, Suemitsu T, Takagi K, Tokushima H, Echizen Y, Katoh K, Umeo K, Maeda Y and Takabatake T 2000 J. Alloys Compounds 313 1-6, Ghelani N, Loo S, Chung D, Sportouch S, Nardi S, Kanatzidis M, Hogan T and Nolas G 2000 Mater. Res. Soc. 626 Z8.6.1). The half-Heusler compound ZrNiSn, in particular, shows promising thermoelectric properties and has been studied by many scientists during recent years (Uher C, Hu S, Yang J, Meisner G P and Morelli D T 1997 Proc. ICT'97: 16th Int. Conf. on Thermoelectrics pp 485-8, Romaka L P, Stadnyk Yu V, Goryn A M, Gorelenko Yu K and Skolozdra R V 1997 Proc. ICT'97: 16th Int. Conf. on Thermoelectrics pp 516-19, Hohl H, Ramirez A P, Goldmann C, Ernst G, Woelfing B and Bucher E 1998 J. Phys.: Condens. Matter 11 1697-709, Oestreich J, Kaefer W, Richardt F, Probst U and Bucher E 1999 Proc. 5th European Workshop on Thermoelectrics pp 192-5). In an effort to find new thermoelectric materials, the half-Heusler compounds of the groups ScM{sup VIII}Sb and YM{sup VIII}Sb (M{sup VIII} = Ni, Pd, Pt) were synthesized by arc melting and the thermoelectric properties were examined by standard characterization methods. Doping experiments showed that it is possible to change the electrical properties of the compounds while retaining the half-Heusler structure. Within the two groups, YPtSb showed the best thermoelectrical properties. At a temperature of 400 K the electrical conductivity of YPtSb is 748{omega}{sup -1} cm{sup -1} and the Seebeck coefficient is 116.3{mu}V K{sup -1}. The thermal conductivity at 400 K extrapolated using the Wiedemann-Franz law is 2.87 W K{sup -1} m{sup -1}. This leads to a dimensionless figure of merit of 0.14.

New study on the XeVIII spectrum

International Nuclear Information System (INIS)

Gallardo, M.; Raineri, M.; Giuliani, M.; Lagorio, C.; Padilla, S.; Sarmiento, R.; Reyna Almandos, J.G.

2005-01-01

Capillary light sources were used to observe the spectrum of seven-times-ionized xenon, XeVIII, in the 300-6000 A wavelength range. Twenty-eight energy levels belonging to the 5s-9s, 5d-9d, 5g-9g, 7i-10i, 9l, 5p-9p, 4f-9f, 6h-9h and 8k-10k configurations were adjusted and 38 new spectral lines were classified. The XeVIII ionization energy was determined with improved accuracy using the polarization model. The analysis was supported by Hartree-Fock calculations. The weighted oscillator strengths for all the observed spectral lines were also calculated considering the fitted values for the energy parameters

New study on the XeVIII spectrum

Energy Technology Data Exchange (ETDEWEB)

Gallardo, M. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail: gallardom@ciop.unlp.edu.ar; Raineri, M. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail: monicar@ciop.unlp.edu.ar; Giuliani, M. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Lagorio, C. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Padilla, S. [Dto. de Fisica, Fac. de C. Exactas y Naturales, Universidad Nacional de Mar del Plata Funes 3350 (7600) Mar del Plata (Argentina); Sarmiento, R. [Dto. De Fisica, Universidad del Atlantico, A.A 1890 Barranquilla (Colombia); Reyna Almandos, J.G. [Centro de Investigaciones Opticas (CIOp) Casilla de Correo 124, 1900 La Plata (Argentina)]. E-mail: jreyna@ciop.unlp.edu.ar

2005-10-15

Capillary light sources were used to observe the spectrum of seven-times-ionized xenon, XeVIII, in the 300-6000 A wavelength range. Twenty-eight energy levels belonging to the 5s-9s, 5d-9d, 5g-9g, 7i-10i, 9l, 5p-9p, 4f-9f, 6h-9h and 8k-10k configurations were adjusted and 38 new spectral lines were classified. The XeVIII ionization energy was determined with improved accuracy using the polarization model. The analysis was supported by Hartree-Fock calculations. The weighted oscillator strengths for all the observed spectral lines were also calculated considering the fitted values for the energy parameters.

Effectiveness of Mind Mapping in English Teaching among VIII Standard Students

Science.gov (United States)

Hallen, D.; Sangeetha, N.

2015-01-01

The aim of the study is to find out the effectiveness of mind mapping technique over conventional method in teaching English at high school level (VIII), in terms of Control and Experimental group. The sample of the study comprised, 60 VIII Standard students in Tiruchendur Taluk. Mind Maps and Achievement Test (Pretest & Posttest) were…

Population pharmacokinetics of recombinant coagulation factor VIII-SingleChain in patients with severe hemophilia A.

Science.gov (United States)

Zhang, Y; Roberts, J; Tortorici, M; Veldman, A; St Ledger, K; Feussner, A; Sidhu, J

2017-06-01

Essentials rVIII-SingleChain is a unique recombinant factor VIII (FVIII) molecule. A population pharmacokinetic model was based on FVIII activity of severe hemophilia A patients. The model was used to simulate factor VIII activity-time profiles for various dosing scenarios. The model supports prolonged dosing of rVIII-SingleChain with intervals of up to twice per week. Background Single-chain recombinant coagulation factor VIII (rVIII-SingleChain) is a unique recombinant coagulation factor VIII molecule. Objectives To: (i) characterize the population pharmacokinetics (PK) of rVIII-SingleChain in patients with severe hemophilia A; (ii) identify correlates of variability in rVIII-SingleChain PK; and (iii) simulate various dosing scenarios of rVIII-SingleChain. Patients/Methods A population PK model was developed, based on FVIII activity levels of 130 patients with severe hemophilia A (n = 91 for ≥ 12-65 years; n = 39 for  85% and > 93% of patients were predicted to maintain FVIII activity level above 1 IU dL -1 , at all times with three-times-weekly dosing (given on days 0, 2, and 4.5) at the lowest (20 IU kg -1 ) and highest (50 IU kg -1 ) doses, respectively. For twice weekly dosing (days 0 and 3.5) of 50 IU kg -1 rVIII-SingleChain, 62-80% of patients across all ages were predicted to maintain a FVIII activity level above 1 IU dL -1 at day 7. Conclusions The population PK model adequately characterized rVIII-SingleChain PK, and the model can be utilized to simulate FVIII activity-time profiles for various dosing scenarios. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

Acquired high titre factor VIII inhibitor with underlying polyarteritis nodosa.

Science.gov (United States)

Snowden, J A; Hutchings, M; Spearing, R; Patton, W N

1997-05-01

We here present the case of a 70-year-old woman referred to our unit for investigation of bleeding. Investigations confirmed a high titre acquired Factor VIII inhibitor. In association there was relapse of systemic illness associated with anti-neutrophil cytoplasmic antibodies (atypical pattern) for which she had been treated five years previously. Immunosuppression was attempted, but it failed to have an impact both on the inhibitor titre and on the underlying disorder. The patient died from multi-organ failure and massive chest hemorrhage. Post-mortem showed necrotizing vasculitis of medium sized vessels at several sites, including the kidney, consistent with a diagnosis of polyarteritis nodosa. Although it is well recognised that Factor VIII inhibitors are found in conjunction with autoimmune disorders, this case is significant in that it is the first associated with histologically proven polyarteritis nodosa type vasculitis. The case illustrates the difficulties in the investigation and management of patients with acquired high titre Factor VIII inhibitors.

Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A.

Science.gov (United States)

Rodgers, Susan; Duncan, Elizabeth

2017-01-01

Hemophilia A is an inherited bleeding disorder caused by a reduced level of factor VIII coagulant activity (FVIII:C) in blood. Bleeding episodes may occur spontaneously in the severe form of hemophilia or after trauma in the milder forms. It is important that patients are diagnosed correctly, which includes placing them into the correct severity category of the disorder so that appropriate treatment can be given. Diagnosis is made by determination of the amount of FVIII:C in the blood, usually using a one-stage factor VIII:C assay. However, approximately one third of patients with mild or moderate hemophilia will have much lower results by the chromogenic assay, with some of them having normal results by the one-stage assay. The chromogenic factor VIII assay is used in some specialized hemophilia reference centers and is recommended for the diagnosis of mild hemophilia A, as this assay is considered to better reflect the severity status of hemophilia patients than the one-stage assay.

Type VIII collagen is elevated in diseases associated with angiogenesis and vascular remodeling

DEFF Research Database (Denmark)

Hansen, N. U. B.; Willumsen, N.; Bülow Sand, Jannie Marie

2016-01-01

Objectives Type VIII collagen is involved in angiogenesis and remodeling of arteries. We hypothesized that type VIII collagen was upregulated in diseases associated with vascular remodeling, e.g. pulmonary fibrosis and cancer. In this paper we present the development and validation of a competitive...

The F309S mutation increases factor VIII secretion in human cell line

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Daianne Maciely Carvalho Fantacini

2016-06-01

Full Text Available ABSTRACT OBJECTIVES: The capacity of a human cell line to secrete recombinant factor VIII with a F309S point mutation was investigated, as was the effect of the addition of chemical chaperones (betaine and sodium-4-phenylbutyrate on the secretion of factor VIII. METHODS: This work used a vector with a F309S mutation in the A1 domain to investigate FVIII production in the HEK 293 human cell line. Factor VIII activity was measured by chromogenic assay. Furthermore, the effects of chemical drugs on the culture were evaluated. RESULTS: The addition of the F309S mutation to a previously described FVIII variant increased FVIII secretion by 4.5 fold. Moreover, the addition of betaine or sodium-4-phenylbutyrate increased the secretion rate of FVIIIΔB proteins in HEK 293 cells, but the same effect was not seen for FVIIIΔB-F309S indicating that all the recombinant protein produced had been efficiently secreted. CONCLUSION: Bioengineering factor VIII expressed in human cells may lead to an efficient production of recombinant factor VIII and contribute toward low-cost coagulation factor replacement therapy for hemophilia A. FVIII-F309S produced in human cells can be effective in vivo.

Myosin VIII regulates protonemal patterning and developmental timing in the moss Physcomitrella patens.

Science.gov (United States)

Wu, Shu-Zon; Ritchie, Julie A; Pan, Ai-Hong; Quatrano, Ralph S; Bezanilla, Magdalena

2011-09-01

Plants have two classes of myosins. While recent work has focused on class XI myosins showing that myosin XI is responsible for organelle motility and cytoplasmic streaming, much less is known about the role of myosin VIII in plant growth and development. We have used a combination of RNAi and insertional knockouts to probe myosin VIII function in the moss Physcomitrella patens. We isolated Δmyo8ABCDE plants demonstrating that myosin VIII is not required for plant viability. However, myosin VIII mutants are smaller than wild-type plants in part due to a defect in cell size. Additionally, Δmyo8ABCDE plants produce more side branches and form gametophores much earlier than wild-type plants. In the absence of nutrient media, Δmyo8ABCDE plants exhibit significant protonemal patterning defects, including highly curved protonemal filaments, morphologically defective side branches, as well as an increase in the number of branches. Exogenous auxin partially rescues protonemal defects in Δmyo8ABCDE plants grown in the absence of nutrients. This result, together with defects in protonemal branching, smaller caulonemal cells, and accelerated development in the Δmyo8ABCDE plants, suggests that myosin VIII is involved in hormone homeostasis in P. patens.

Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine.

Science.gov (United States)

Gilbert, G E; Drinkwater, D

1993-09-21

Phosphatidylserine, a negatively charged lipid, is exposed on the platelet membrane following cell stimulation, correlating with the expression of factor VIII receptors. We have explored the importance of the negative electrostatic potential of phosphatidylserine vs chemical moieties of phosphatidylserine for specific membrane binding of factor VIII. Fluorescein-labeled factor VIII bound to membranes containing 15% phosphatidic acid, a negatively charged phospholipid, with low affinity compared to phosphatidylserine-containing membranes. Binding was not specific as it was inhibited by other proteins in plasma. Factor VIII bound to membranes containing 10% phosphatidylserine in spite of a varying net charge provided by 0-15% stearylamine, a positively charged lipid. The soluble phosphatidylserine moiety, O-phospho-L-serine, inhibited factor VIII binding to phosphatidylserine-containing membranes with a Ki of 20 mM, but the stereoisomer, O-phospho-D-serine, was 5-fold less effective. Furthermore, binding of factor VIII to membranes containing synthetic phosphatidyl-D-serine was 5-fold less than binding to membranes containing phosphatidyl-L-serine. Membranes containing synthetic phosphatidyl-L-homoserine, differing from phosphatidylserine by a single methylene, supported high-affinity binding, but it was not specific as factor VIII was displaced by other plasma proteins. O-Phospho-L-serine also inhibited the binding of factor VIII to platelet-derived microparticles with a Ki of 20 mM, and the stereoisomer was 4-fold less effective. These results indicate that membrane binding of factor VIII is mediated by a stereoselective recognition O-phospho-L-serine of phosphatidylserine and that negative electrostatic potential is of lesser importance.

VIII Olimpíada Brasileira de Astronomia e Astronáutica

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Garcia Canalle, João Batista; Villas da Rocha, Jaime Fernando; Wuensche de Souza, Carlos Alexandre; Pereira Ortiz, Roberto; Aguilera, Nuricel Villalonga; Padilha, Maria De Fátima Catta Preta; Pessoa Filho, José Bezerra; Soares Rodrigues, Ivette Maria

2007-07-01

Neste trabalho apresentamos as motivações pelas quais organizamos, em conjunto, pela primeira vez, a Olimpíada Brasileira de Astronomia incluindo a Astronáutica, em colaboração com a Agência Espacial Brasileira. Esta ampliação contribuiu para atrair ainda mais alunos, professores, escolas e patrocinadores para participarem desta Olimpíada. Em 2005 participaram da VIII Olimpíada Brasileira de Astronomia e Astronáutica (VIII OBA) 187.726 alunos distribuídos por 3.229 escolas, pertencentes a todos os estados brasileiros, incluindo o Distrito Federal. O crescimento em número de alunos participantes foi 52,4% maior do que em 2004. Em abril de 2005 organizamos, em Itapecerica da Serra, SP, um curso para os 50 alunos previamente selecionados e participantes da VII OBA e ao final selecionamos, dentre eles, uma equipe de 5 alunos, os quais representaram o Brasil na X Olimpíada Internacional de Astronomia, na China, em outubro de 2005. Ganhamos, pela primeira vez, uma medalha de ouro naquele evento. Em Agosto de 2005, organizamos a VIII Escola de Agosto para 50 alunos e respectivos professores, em Águas de Lindóia, SP, juntamente com a XXXI reunião anual da Sociedade Astronômica Brasileira (SAB). Em novembro de 2005 realizamos a I Jornada Espacial, em São José dos Campos, com 22 alunos e 22 professores selecionados dentre os participantes que melhores resultados obtiveram nas questões de Astronáutica da VIII OBA. Neste trabalho detalhamos os resultados da VIII OBA bem como as ações subseqüentes.

Dissemination of evidence-based cancer control interventions among Catholic faith-based organizations: results from the CRUZA randomized trial.

Science.gov (United States)

Allen, Jennifer D; Torres, Maria Idalí; Tom, Laura S; Leyva, Bryan; Galeas, Ana V; Ospino, Hosffman

2016-05-18

The CRUZA randomized trial tested the efficacy of an organizational-level intervention to increase the capacity of Catholic faith-based organizations (FBOs) serving Latinos to implement evidence-based strategies (EBS) for cancer control. Thirty-one Catholic parishes were enrolled. Twenty were randomized to a "capacity enhancement" (CE) intervention and 11 to a "standard dissemination" (SD) condition. Each received a Program Implementation Manual and Toolkit of materials culturally adapted for FBOs with Latino audiences for five types of EBS recommended by the US Preventive Services Community Guide. CE parishes were offered a menu of capacity-building activities over a 3-month period, while SD parishes were provided a one-time consultation by an Intervention Specialist. Baseline and follow-up surveys compared the number and types of EBS offered. At baseline, only one parish had offered any cancer-related program in the prior year, yet a third (36 %) had offered some other type of health program or service. At post-intervention follow-up, all parishes offered a greater number of EBS. The only statistically significant difference between CE and SD groups was the number of parishes offering small media interventions (90 % in CE, 64 % in SD; p support to carry out programming. Further research is needed to examine the extent to which program offerings continued after the period of grant funding. Clinicaltrials.gov NCT01740219 .

Analysis of mutations in the entire coding sequence of the factor VIII gene

Energy Technology Data Exchange (ETDEWEB)

Bidichadani, S.I.; Lanyon, W.G.; Connor, J.M. [Glascow Univ. (United Kingdom)] [and others

1994-09-01

Hemophilia A is a common X-linked recessive disorder of bleeding caused by deleterious mutations in the gene for clotting factor VIII. The large size of the factor VIII gene, the high frequency of de novo mutations and its tissue-specific expression complicate the detection of mutations. We have used a combination of RT-PCR of ectopic factor VIII transcripts and genomic DNA-PCRs to amplify the entire essential sequence of the factor VIII gene. This is followed by chemical mismatch cleavage analysis and direct sequencing in order to facilitate a comprehensive search for mutations. We describe the characterization of nine potentially pathogenic mutations, six of which are novel. In each case, a correlation of the genotype with the observed phenotype is presented. In order to evaluate the pathogenicity of the five missense mutations detected, we have analyzed them for evolutionary sequence conservation and for their involvement of sequence motifs catalogued in the PROSITE database of protein sites and patterns.

The vestibulocochlear nerve (VIII).

Science.gov (United States)

Benoudiba, F; Toulgoat, F; Sarrazin, J-L

2013-10-01

The vestibulocochlear nerve (8th cranial nerve) is a sensory nerve. It is made up of two nerves, the cochlear, which transmits sound and the vestibular which controls balance. It is an intracranial nerve which runs from the sensory receptors in the internal ear to the brain stem nuclei and finally to the auditory areas: the post-central gyrus and superior temporal auditory cortex. The most common lesions responsible for damage to VIII are vestibular Schwannomas. This report reviews the anatomy and various investigations of the nerve. Copyright © 2013. Published by Elsevier Masson SAS.

Fundamentos geométricos, metrológicos y sistemas de proporción en la arquitectura altomedieval asturiana (siglos VIII y X

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Arias Páramo, Lorenzo

2001-12-01

Full Text Available This paper aims to establish the criteria that ruled the proportions and order in early mediaeval Asturian architecture ( 8th-10th centuries. It includes the study of the metrological system and the module of proportions used in these buildings. As a result, these principles are used as a basis for establishing the forms and principles of proportion common to all Asturian architecture.Estudiamos los criterios de orden y proporción presentes en la arquitectura altomedieval asturiana (siglos VIII-X. El estudio abarca igualmente el sistema metrologico aplicado, estudiando asimismo el módulo de proporción presente en sus edificios. A partir de estos principios se establecen las formas tipológicas y los cánones de proporción comunes al conjunto de la arquitectura asturiana.

Practical experience and lessons learned through implementation of Appendix VIII performance demonstration requirements

International Nuclear Information System (INIS)

Ashwin, P.J.; Becker, F.L.; Latiolais, C.L.; Spanner, J.C.

1996-01-01

To provide the US nuclear industry with a uniform implementation of the Performance Demonstration requirements within the 1989 edition of ASME Section XI, Appendix VIII, representatives from all US nuclear utilities formed the Performance Demonstration Initiative (PDI). The PDI recognized the potential benefits that Appendix VIII offered the nuclear industry and initiated a proactive approach to implement the requirements. In doing so it was expected that performance demonstration of ultrasonic examination procedures would allow for improvement in the efficiency and credibility of inservice inspection to be realized. Explicit within the performance demonstration requirements of Appendix VIII is the need for a Performance Demonstration Administrator, a difficult requirement to fulfill. Not only must the administrator exhibit the attributes of understanding the demonstration requirements, but also have solid technical knowledge, integrity and be able to interface with the industry at all levels, from operations to regulatory. For the nuclear industry, the EPRI NDE Center is an obvious choice to fulfill this position. This paper provides a brief background of the PDI, a nuclear industry-wide initiative to implement the performance demonstration requirements of Appendix VIII. Even though the consensus approach adopted by the PDI is discussed, the paper's primary objective is to provide examples of the lessons learned by the Center through the specific requirements of Appendix VIII

Igor Zabel 14. VIII 1958 - 23. VII 2005

Index Scriptorium Estoniae

2005-01-01

Igor Zabel oli Ida-Euroopa tuntumaid kunstiteoreetikuid ja kuraatoreid. Töötas 1986. aastast Ljubljana moodsa kunsti muuseumi kuraatorina. 9. VIII avatakse seal viimane I. Zabeli kureeritud näitus "Territories, Identities, Nets-Slovene Art 1995-2005"

Home therapy with continuous infusion of factor VIII after minor surgery or serious haemorrhage.

Science.gov (United States)

Varon, D; Schulman, S; Bashari, D; Martinowitz, U

1996-10-01

Administration of factor VIII (F VIII) concentrates by continuous infusion is now routinely used at several haemophilia centers but almost exclusively for hospitalized patients. We evaluated various aspects of home therapy with continuous infusion of an immunoaffinity purified F VIII concentrate (Monoclate P®, Armour) in patients who would normally have been treated with high doses in bolus injections or with continuous infusion as in-patients. Twenty haemophilia A patients, eight after minor surgery and 12 for serious haemorrhage, received continuous infusion with undiluted F VIII by a minipump for a mean of 0.9 days in the hospital, followed by 3.3 days at home. Infusion bags were exchanged every 2.5 days. No haemorrhagic complications occurred, and five haemorrhages that had been resistant to treatment with bolus injections responded promptly to the continuous infusion. There were no technical problems and patient compliance and acceptance was good. We find this mode of therapy safe, efficacious and convenient for the patients as well as for the staff.

Produção de Carne em Cordeiros Cruza Border Leicester com Ovelhas Corriedale e Ideal

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Osório José Carlos da Silveira

2002-01-01

Full Text Available O estudo objetivou oferecer informações sobre a morfologia (in vivo e na carcaça, características comerciais, componentes do peso vivo, qualidade da carcaça e da carne em cordeiros não castrados cruzas de Border Leicester com ovelhas Corriedale e Ideal, criados em condições de campo nativo no Rio Grande do Sul, Brasil. Foram utilizados 24 cordeiros, 11 procedentes do cruzamento de Border x Corriedale e 13 de Border Leicester x Ideal, sacrificados com 6,5 meses de idade. Foi verificado um efeito entre os cruzamentos para a perda ao resfriamento (em kg e %, peso e percentagem da pele, peso e percentagem do pescoço e capacidade de retenção de água. Igualmente, foi verificado que há diferença no desenvolvimento relativo dos componentes do peso vivo, composição regional da carcaça e composição tecidual da paleta entre os cordeiros Border Leicester x Corriedale e Border Leicester x Ideal e, dentro de cada genotipo verificou-se uma diferença quantitativa e qualitativa entre a paleta e a perna. As diferença quanto à qualidade da carcaça e carne não apresentam importância prática que justifique uma diferenciação do produto; porém, a comercialização deve ser com base no peso de carcaça fria e não com base no peso vivo ou carcaça quente. A paleta é mais precoce que a perna em ambos grupos genéticos.

Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia a

NARCIS (Netherlands)

C.L. Eckhardt (Corien); A.S. van Velzen (Alice); M.A.D. Peters (Marjolein); J. Astermark (Jan); P.P. Brons; G. Castaman (Giancarlo); M.H. Cnossen (Marjon); N. Dors (N.); C. Escuriola-Ettingshausen (Carmen); K. Hamulyák (K.); D.P. Hart (Daniel); C.R.M. Hay (Charles R.); S. Haya (Saturnino); W.L. van Heerde; C. Hermans (Cédric); M. Holmström (Margareta); V. Jimenez-Yuste (Victor); R.D. Keenan (Russell); R. Klamroth (Robert); B.A.P. Laros-Van Gorkom (Britta); F.W.G. Leebeek (Frank); R. Liesner (Ri); A. Mäkipernaa (Anne); C. Male (Christoph); E.P. Mauser-Bunschoten (Eveline); M.G. Mazzucconi (Maria); S. McRae (Simon); K. Meijer (K.); M. Mitchell (Michael); M. Morfini (Massimo); M.R. Nijziel (Marten); J. Oldenburg (Jan); K. Peerlinck; P. Petrini (Pia); H. Platokouki (Helena); S.E. Reitter-Pfoertner (Sylvia); E. Santagostino (Elena); P. Schinco (Piercarla); F.J.W. Smiers (Frans); K.D. Siegmund (Kimberly); A. Tagliaferri (Annarita); T.T. Yee (Thynn); P.W. Kamphuisen (Pieter Willem); J.G. van der Bom (Anske); K. Fijnvandraat

2013-01-01

textabstractNeutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern. Identification of high-risk patients is hampered by lack of data that take exposure days to therapeutic factor VIII concentrates into

Characterization of five partial deletions of the factor VIII gene

International Nuclear Information System (INIS)

Youssoufian, H.; Antonarakis, S.E.; Aronis, S.; Tsiftis, G.; Phillips, D.G.; Kazazian, H.H. Jr.

1987-01-01

Hemophilia A is an X-linked disorder of coagulation caused by a deficiency of factor VIII. By using cloned DNA probes, the authors have characterized the following five different partial deletions of the factor VIII gene from a panel of 83 patients with hemophilia A: (i) a 7-kilobase (kb) deletion that eliminates exon 6; (ii) a 2.5-kb deletion that eliminates 5' sequences of exon 14; (iii) a deletion of at least 7 kb that eliminates exons 24 and 25; (iv) a deletion of at least 16 kb that eliminates exons 23-25; and (v) a 5.5-kb deletion that eliminates exon 22. The first four deletions are associated with severe hemophilia A. By contrast, the last deletion is associated with moderate disease, possibly because of in-frame splicing from adjacent exons. None of those patients with partial gene deletions had circulating inhibitors to factor VIII. One deletion occurred de novo in a germ cell of the maternal grandmother, while a second deletion occurred in a germ cell of the maternal grandfather. These observations demonstrate that de novo deletions of X-linked genes can occur in either male or female gametes

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

Energy Technology Data Exchange (ETDEWEB)

Ngo, J.C.; Huang, M.; Roth, D.A.; Furie, B.C.; Furie, B. (Wyeth); (MBL)

2008-06-03

Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca{sup 2+} and two Cu{sup 2+} ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

Energy Technology Data Exchange (ETDEWEB)

Chi Ki Ngo,J.; Huang, M.; Roth, D.; Furie, B.; Furie, B.

2008-01-01

Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca(2+) and two Cu(2+) ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

Evaluación de la producción de carne de ganado criollo patagónico

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Nora Abbiati C.

2012-08-01

Full Text Available Objetivo. Evaluar la producción de carne del ganado Criollo Patagónico respecto al Angus y cruzas entre ambas razas. Materiales y métodos. Se dispuso de una muestra de 42 animales de los genotipos Criollo Patagónico, Angus y cruza entre ambos, clasificados en novillitos o vaquillonas, terminados en feed lot durante un período de 114 y 156 días, a partir de los cuales se conformaron ocho grupos de análisis desbalanceados. Para la parte exploratoria se empleó análisis factorial. Se usaron modelos lineales mixtos para contemplar las correlaciones entre las mediciones sobre un mismo animal. Resultados. Se pudo constatar diferencias entre las medias de los pesos a faena de los dos períodos de engorde y que esta ganancia de peso se depositó en los cortes de menor valor comercial. Con relación al rendimiento de los cortes de alto valor económico, se detectó interacción entre éstos y los grupos, identificándose diferencias entre grupos para algunos de los cortes. Conclusiones. En virtud de los resultados obtenidos, se considera promisoria la producción de carne del ganado Criollo Patagónico con relación al rendimiento de los cortes de alto valor económico, pues sus rendimientos medios sólo se vieron superados en bife ancho por su cruza con Angus.

Henry VIII, McLeod syndrome and Jacquetta's curse.

Science.gov (United States)

Stride, P; Lopes Floro, K

2013-01-01

The mental decline of King Henry VIII from being a jovial, charismatic and athletic young man into an increasingly paranoid, brutal tyrant in later life, ever more concerned at his lack of one or more male heirs, has attracted many medical diagnostic theories. Previous hypotheses have included diabetes, syphilis and hypothyroidism, among others. However, these inadequately explain Henry's failure to produce a male heir, despite multiple pairings. The latest postulated diagnoses for Henry are the coexistence of both Kell blood group antigenicity (possibly inherited from Jacquetta Woodville, Henry's maternal great grandmother) causing related impaired fertility, and McLeod syndrome, causing psychotic changes. As the mutated McLeod protein of the syndrome significantly reduces the expression, effectively inactivating the Kell antigen, we critically review this theory, examining in detail the pathophysiology of these conditions and assessing the genealogy of Henry VIII and its effect in subsequent generations.

Evidence for the formation of sodium hassate(VIII)

International Nuclear Information System (INIS)

Zweidorf, A. von; Angert, R.; Bruechle, W.; Buerger, S.; Eberhardt, K.; Eichler, R.; Hummrich, H.; Jaeger, E.; Kling, H.O.; Kratz, J.V.; Kuczewski, B.; Langrock, G.; Mendel, M.; Rieth, U.; Schaedel, M.; Schausten, B.; Schimpf, E.; Thoerle, P.; Trautmann, N.; Tsukada, K.; Wiehl, N.; Wirth, G.

2004-01-01

Hassium, element 108, was produced in the fusion reaction between 26 Mg and 248 Cm. The hassium recoils were oxidized in-situ to a highly volatile oxide, presumably HsO 4 , and were transported in a mixture of He and O 2 to a deposition and detection system. The latter consisted of 16 silicon PIN-photodiodes facing a layer of NaOH, which served, in the presence of a certain partial pressure of water in the transport gas, as reactive surface for the deposition of the volatile tetroxides. Six correlated α-decay chains of Hs were detected in the first 5 detectors centred around detection position 3. In analogy to OsO 4 , which forms Na 2 [OsO 4 (OH) 2 ], an osmate(VIII), with aqueous NaOH, HsO 4 presumably was deposited as Na 2 [HsO 4 (OH) 2 ], a hassate(VIII). (orig.)

The spectrum and term system of S VIII

International Nuclear Information System (INIS)

Bengtsson, P.; Jupen, C.; Engstroem, L.; Redfors, A.; Westerlind, M.

1993-01-01

The spectrum of seven times ionized sulfur, S VIII, has been observed in the wavelength range 50-1200 A. Both beam-foil and laser-produced plasma light sources have been used. 71 new lines representing the transitions 2p 5 -2p 4 3d, 2p 4 3s-3p, 3p-3d, 3d-4f, 4f-5g and 5g-6h have been identified and 100 energy levels, of which 46 are new, are now accurately established. The spectral analysis is supported by isoelectronic comparisons along the F I-sequence and by parametric least-squares fits of Slater integrals to the observed levels. The ionization potential in S VIII is determined to 2 651 899 ± 60 cm -1 and estimated ionization energies are derived for the isoelectronic elements between F I and Ar X. (orig.)

Purification and characterization of factor VIII 1,689-Cys: a nonfunctional cofactor occurring in a patient with severe hemophilia A.

Science.gov (United States)

O'Brien, D P; Tuddenham, E G

1989-06-01

We have purified the factor VIII from a CRM+ Hemophilia A plasma (90 U/dL VIII:Ag but 0 U/dL VIII:C) and analyzed the protein before and after thrombin activation by Western blotting with monoclonal antibodies (MoAbs). Normal or patient citrated plasma was ultracentrifuged, cryo-ethanol-precipitated and chromatographed on Sepharose 6B. The void volume fractions were reduced and subjected to ion exchange chromatography yielding material of specific activity approximately 1,000 U/mg protein (VIII:C or VIII:Ag). Factor VIII purified in this way from normal plasma is fully activatable by thrombin with proteolytic fragmentation as previously described by F. Rotblat et al (Biochemistry 24: 4294, 1985). Factor VIII 1,689-Cys has the normal distribution of factor VIII light and heavy chains prior to thrombin activation. After exposure to thrombin the heavy chain polypeptides were fully proteolysed but the light chain was totally resistant to cleavage. This is consistent with the demonstration in the patient's leucocyte DNA of a C to T transition in codon 1,689 converting Arg to Cys at the light chain thrombin cleavage site as previously described by J. Gitschier et al (Blood 72:1022, 1988). Uncleaved light chain of Factor VIII 1,689-Cys is not released from von Willebrand factor (vWF) by thrombin, but this is not the sole cause of the functional defect since the protein purified free of vWF has no coagulant activity. We conclude that the functional defect in factor VIII 1,689-Cys is a consequence of failure to release the acidic peptide from the light chain upon thrombin activation.

40 CFR Appendix Viii to Part 266 - Organic Compounds for Which Residues Must Be Analyzed

Science.gov (United States)

2010-07-01

... AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR THE MANAGEMENT OF SPECIFIC HAZARDOUS WASTES AND SPECIFIC TYPES OF HAZARDOUS WASTE MANAGEMENT FACILITIES Pt. 266, App. VIII Appendix VIII to Part 266... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Organic Compounds for Which Residues...

40 CFR Appendix Viii to Part 268 - LDR Effective Dates of Injected Prohibited Hazardous Wastes

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false LDR Effective Dates of Injected Prohibited Hazardous Wastes VIII Appendix VIII to Part 268 Protection of Environment ENVIRONMENTAL PROTECTION... to Part 268—LDR Effective Dates of Injected Prohibited Hazardous Wastes National Capacity LDR...

Structural characterization of the novel aminoglycoside phosphotransferase AphVIII from Streptomyces rimosus with enzymatic activity modulated by phosphorylation

Energy Technology Data Exchange (ETDEWEB)

Boyko, Konstantin M., E-mail: kmb@inbi.ras.ru [Bach Institute of Biochemistry, Federal Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt. 33, Bld. 2, 119071, Moscow (Russian Federation); National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation); Gorbacheva, Marina A.; Korzhenevskiy, Dmitry A. [National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation); Alekseeva, Maria G.; Mavletova, Dilara A.; Zakharevich, Natalia V.; Elizarov, Sergey M.; Rudakova, Natalia N.; Danilenko, Valery N. [Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina str. 3, Moscow, 119333 (Russian Federation); Popov, Vladimir O. [Bach Institute of Biochemistry, Federal Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt. 33, Bld. 2, 119071, Moscow (Russian Federation); National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation)

2016-09-02

Aminoglycoside phosphotransferases represent a broad class of enzymes that promote bacterial resistance to aminoglycoside antibiotics via the phosphorylation of hydroxyl groups in the latter. Here we report the spatial structure of the 3′-aminoglycoside phosphotransferase of novel VIII class (AphVIII) solved by X-ray diffraction method with a resolution of 2.15 Å. Deep analysis of APHVIII structure and its comparison with known structures of aminoglycoside phosphotransferases of various types reveals that AphVIII has a typical two-domain fold and, however, possesses some unique characteristics that distinguish the enzyme from its known homologues. The most important difference is the presence of the activation loop with unique Ser146 residue. We demonstrate that in the apo-state of the enzyme the activation loop does not interact with other parts of the enzyme and seems to adopt catalytically competent state only after substrate binding. - Highlights: • 3D structure of the novel aminoglycoside phosphotransferase AphVIII was obtained. • AphVIII activation loop is clearly identified in the electron density. • AphVIII has some unique structural features in its substrate C-ring binding pocket.

Hemodialysis in a patient with severe hemophilia A and factor VIII inhibitor.

Science.gov (United States)

Gopalakrishnan, Natarajan; Usha, Thiruvengadam; Thopalan, Balasubramaniyan; Dhanapriya, Jeyachandran; Dineshkumar, Thanigachalam; Thirumalvalavan, Kaliaperumal; Sakthirajan, Ramanathan

2016-10-01

Hemophilia A is a hereditary X-linked recessive disease caused by mutations in the gene encoding factor VIII (FVIII), occurring in 1 out of 10,000 persons. Life expectancy and quality of life have dramatically improved recently in patients with hemophilia. Chronic kidney disease and need for renal replacement therapy in these patients are rare. The development of inhibitors to FVIII is the most serious complication of hemophilia and makes treatment of bleeds very challenging. We describe here a 28-year-old male patient with severe hemophilia A with presence of factor VIII inhibitor, who had end stage renal disease. Central venous access device was inserted along with infusion of factor eight inhibitor bypass activity before and after the procedure. He is currently on thrice weekly hemodialysis and doing well for 6 months without bleeding episodes. To our knowledge, hemophilia A with factor VIII inhibitor managed with hemodialysis has not been reported so far. © 2016 International Society for Hemodialysis.

Spectrophotometric determination of hydrogen peroxide with osmium(VIII) and m-carboxyphenylfluorone.

Science.gov (United States)

Hoshino, Mitsuru; Kamino, Shinichiro; Doi, Mitsunobu; Takada, Shingo; Mitani, Shota; Yanagihara, Rika; Asano, Mamiko; Yamaguchi, Takako; Fujita, Yoshikazu

2014-01-03

Spectrophotometric determination of hydrogen peroxide was accomplished with osmium(VIII) and m-carboxyphenylfluorone (MCPF) in the presence of cetyltrimethylammonium chloride (CTAC). In the determination of hydrogen peroxide based on the fading of the color of osmium(VIII)-MCPF complex, Beer's law was obeyed in the range 20-406 ng mL(-1), with an effective molar absorption coefficient (at 580 nm) of 5.21×10(4) L mol(-1) cm(-1) and a relative standard deviation of 0.33% (n=6). Further, we performed the characterization of MCPF and obtained the crystal structure. Copyright © 2013 Elsevier B.V. All rights reserved.

La inestabilidad política de los reyes visigodos de Toledo (s. VI-VIII: balance historiográfico y nueva propuesta de análisis

Directory of Open Access Journals (Sweden)

Sabrina Soledad Orlowski

2012-03-01

Full Text Available La inestabilidad política regia visigoda es un fenómeno tan constante en la documentación de los siglos VI-VIII que motiva una investigación para dar cuenta de sus principios estructurales. Se propone que la evolución política de la realeza visigoda corresponde a lógicas de funcionamiento de las aristocracias en sociedades de dominación incompleta, que expresan una dinámica general de la temprana Edad Media. Las opiniones de los autores sobre este fenómeno son tan variadas que se vuelve imperioso realizar un balance del estado de la investigación, detectar los problemas existentes y, lo más importante, delinear una línea de trabajo a seguir

Factor VIII-associated antigen in human lymphatic endothelium.

Science.gov (United States)

Nagle, R B; Witte, M H; Martinez, A P; Witte, C L; Hendrix, M J; Way, D; Reed, K

1987-03-01

Lymphatic vascular endothelium both on tissue section and in culture exhibits positivity for Factor VIII-associated antigen although staining is generally less intense and more spotty than in comparable blood vascular endothelium. Lymphatic endothelium also exhibits Weibel-Palade bodies. Neither marker, therefore, reliably distinguishes blood vascular endothelium from lymphatic endothelium.

Time Transfer Experiment by TCE on the ETS-VIII Satellite

National Research Council Canada - National Science Library

Nakagawa, Fumimaru; Takahashi, Yasuhiro; Amagai, Jun; Tabuchi, Ryo; Hama, Shin'ichi; Hosokawa, Mizuhiko

2007-01-01

.... At NICT, we developed Time Comparison Equipment (TCE) both onboard ETS-VIII and in the Earth station for precise time transfer between the atomic clocks on the satellite and a ground reference clock...

Mechanistic aspects of Os(VIII) catalysed oxidation of loop diuretic ...

Indian Academy of Sciences (India)

furosemide by Ag(III) periodate complex in aqueous alkaline medium. SHWETA J .... Os(VIII) catalysed DPA oxidation, the order in [OH. −. ] ... Victoria-3170, Australia) connected to a rapid ..... follows. The furosemide, periodate and hydroxide ion.

PERSEPSI SISWA KELAS VIII TENTANG KESEHATAN REPRODUKSI REMAJA DAN PENYAKIT MENULAR SEKSUAL

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Omega Rianda Rustian

2015-06-01

This study is based on interviews conducted in one of the BK school teacher. This study aimed to determine the perception class VIII student perceptions on adolescent reproductive health and sexually transmitted diseases in SMP Islam Sultan Agung 1 Semarang. The method used in this research is descriptive quantitative survey methods. Population in this research is class VIII SMP Islam Sultan Agung 1 Semarang totaling 151 students with a sampling technique used is accidental to obtain a sample of 60. Data collection tools in the form of a psychological scale with data analysis techniques using descriptive analysis percentage. The average result of students' perceptions on adolescent reproductive health in the high category (74% and perceptions of students about sexually transmitted diseases in the very high category (76%. That class VIII SMP Islam Sultan Agung 1 Semarang already have an idea of the meaning of adolescent reproductive health is a state of good health both physically healthy, functioning, as well as reproductive performance in adolescent and the  meaning of sexually transmitted diseases are caused by viruses, parasites, or function as a result of sexual intercourse.

Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation.

Science.gov (United States)

Witsenburg, C P J; Rosendaal, F R; Middeldorp, J M; Van der Meer, F J M; Scherjon, S A

2005-01-01

Recently, acquired as well as genetic prothrombotic factors are associated with thrombotic events. These factors have also been related to conditions of uteroplacental insufficiency such as pre-eclampsia, HELLP syndrome and severe intrauterine growth restriction (IUGR). The aim of this study was to determine whether elevated factor VIII levels are associated with uteroplacental insufficiency, in particular pre-eclampsia, HELLP syndrome or pregnancy-induced hypertension and intrauterine growth retardation. Plasma samples of 75 women with a history of pregnancy complicated by pre-eclampsia, HELLP syndrome, pregnancy induced hypertension or intrauterine growth restriction were tested for factor VIII:C (FVIII:C) levels at a minimum of 10 weeks post-partum. Laboratory results were compared to factor VIII:C levels found in a healthy control group of 272 women. Mean factor VIII:C levels were similar at 123 IU/dl in both the patient group and the controls. In a logistic regression model, after adjusting for age and blood group, no effect of factor VIII:C levels on the risk of pregnancy complications was observed, with the exception of IUGR with (OR 2.9, CI 1.0-8.7) or without hypertension (OR 2.0, CI 0.7-6.4). If the elevated level of factor VIII would be the sole factor responsible for the increased risk observed, one would expect to find an effect of blood group on risk as well (blood group being an important determinant of FVIII:C). While no such effect could be shown a causal relationship between elevated levels of factor VIII and conditions of uteroplacental insufficiency such as pre-eclampsia, HELLP syndrome, pregnancy-induced hypertension and IUGR is not very likely.

Class VIII Medical Materiel Controls in the U.S. European Command

National Research Council Canada - National Science Library

1991-01-01

.... Class VIII medical materiel inventories are maintained as part of the U.S. war reserve stocks to ensure military readiness and to provide needed health care during wartime or contingencies. The U.S...

Construction of a mouse model of factor VIII deficiency by gene targeting

Energy Technology Data Exchange (ETDEWEB)

Bi, L.; Lawler, A.; Gearhart, J. [Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [and others

1994-09-01

To develop a small animal model of hemophilia A for gene therapy experiments, we set out to construct a mouse model for factor VIII deficiency by gene targeting. First, we screened a mouse liver cDNA library using a human FVIII cDNA probe. We cloned a 2.6 Kb partial mouse factor VIII cDNA which extends from 800 base pairs of the 3{prime} end of exon 14 to the 5{prime} end of exon 26. A mouse genomic library made from strain 129 was then screened to obtain genomic fragments covering the exons desired for homologous recombination. Two genomic clones were obtained, and one covering exon 15 through 22 was used for gene targeting. To make gene targeting constructs, a 5.8 Kb genomic DNA fragment covering exons 15 to 19 of the mouse FVIII gene was subcloned, and the neo expression cassette was inserted into exons 16 and 17 separately by different strategies. These two constructs were named MFVIIIC-16 and MFVIIIC-17. The constructs were linearized and transfected into strain 129 mouse ES cells by electroporation. Factor VIII gene-knockout ES cell lines were selected by G-418 and screened by genomic Southern blots. Eight exon 16 targeted cell lines and five exon 17 targeted cell lines were obtained. Three cell lines from each construct were injected into blastocysts and surgically transferred into foster mothers. Multiple chimeric mice with 70-90% hair color derived from the ES-cell genotype were seen with both constructs. Germ line transmission of the ES-cell genotype has been obtained for the MFVIIIC-16 construct, and multiple hemophilia A carrier females have been identified. Factor VIII-deficient males will be conceived soon.

RELATIONSHIP OF INTEREST, LEARNING MOTIVATION AND ATTITUDE WITH RESULTS LEARNING CLASS VIII SMP STATE 13 MAKASSAR

Directory of Open Access Journals (Sweden)

Putri Athirah Azis

2016-12-01

Full Text Available The study aims at examining (1 the correlation of learning interest towards learning result of grade students, (2 the correlation of learning motivation towards learning result of grade students, (3 the correlation of students attitude towards learning result, (4 the correlationof interest, learning motivation, and attitude collaboratively towards learning result. The study is an ex post facto. The population of the study was grade VIII at SMPN 13 Makassar. Samples were 105 students taken by employing random sampling technique. Data were collected through questionnaire and documentation. Data were analyzed using regression test. The result of study reveal that (1 there is significant correlation (p<0,01 of interest towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,718 and its effectiveness contribution (R2 is 51,5%, (2 there is significant correlation (p<0,01 of motivation towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,775 and its effectiveness contribution (R2 is 60,1%, (3 there is significant correlation (p<0,01 of attitude towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,737 and its effectiveness contribution (R2 is 54,4%, (4 there is significant correlation (p<0,01 of interest, motivation and attitude collaboratively towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,861 and its effectiveness contribution (R2 is 74,1%,

Compact invariant sets of the Bianchi VIII and Bianchi IX Hamiltonian systems

International Nuclear Information System (INIS)

Starkov, Konstantin E.

2011-01-01

In this Letter we prove that all compact invariant sets of the Bianchi VIII Hamiltonian system are contained in the set described by several simple linear equalities and inequalities. Moreover, we describe invariant domains in which the phase flow of this system has no recurrence property and show that there are no periodic orbits and neither homoclinic, nor heteroclinic orbits contained in the zero level set of its Hamiltonian. Similar results are obtained for the Bianchi IX Hamiltonian system. -- Highlights: → Zero level set of Hamiltonian of Bianchi VIII/IX systems contains no periodic orbits. → Similar conditions for homoclinic/heteroclinic orbits are given. → General nonexistence conditions of compact invariant sets are got.

Compact invariant sets of the Bianchi VIII and Bianchi IX Hamiltonian systems

Energy Technology Data Exchange (ETDEWEB)

Starkov, Konstantin E., E-mail: konst@citedi.mx [CITEDI-IPN, Av. del Parque 1310, Mesa de Otay, Tijuana, BC (Mexico)

2011-08-22

In this Letter we prove that all compact invariant sets of the Bianchi VIII Hamiltonian system are contained in the set described by several simple linear equalities and inequalities. Moreover, we describe invariant domains in which the phase flow of this system has no recurrence property and show that there are no periodic orbits and neither homoclinic, nor heteroclinic orbits contained in the zero level set of its Hamiltonian. Similar results are obtained for the Bianchi IX Hamiltonian system. -- Highlights: → Zero level set of Hamiltonian of Bianchi VIII/IX systems contains no periodic orbits. → Similar conditions for homoclinic/heteroclinic orbits are given. → General nonexistence conditions of compact invariant sets are got.

Successful Pregnancy in a Patient with Combined Deficiency of Factor V and Factor VIII.

Science.gov (United States)

El Adib, Ahmed Ghassan; Majdi, Farah; Dilai, Mohamed Othmane; Asmouki, Hamid; Bassir, Ahlam; Harou, Karam; Soumani, Abderraouf; Younous, Said; Mahmal, Lahoucine

2014-01-01

Inherited combined factor V and factor VIII deficiency (F5F8D) is autosomal recessive transmission disorder. Epistaxis, postsurgical bleeding, and menorrhagia are the most common symptoms. The risk of miscarriage and placental abruption is consequent. We report a case of successful pregnancy in a patient with F5F8D. 20-year-old woman, born of consanguineous parents, third gestate, first parity, two miscarriages, admitted for child birth of a spontaneous pregnancy estimated at 38 weeks and was diagnosed with F5F8D. At admission, patient was hemodynamically stable, with good obstetric conditions. The biologic results showed low levels of PT (52%), factor V (7%), and factor VIII (5%), and the activated partial thromboplastin time was prolonged (68,6%). Parturient was admitted in intensive care unit, maternal and fetal monitoring was performed. Fresh frozen plasma (FFP) and factor VIII concentrates were perfused at the induction of labor. Analgesia used fentanyl titration. The delivery gave birth to a newborn male, with Apgar 10/10 and 3000 g. The puerperium was simple without any important bleeding. Laboratory tests for the newborn were acceptable. Little literature is available on this subject and there are no guidelines available concerning pregnancy; we chose to prescribe a combination of factor VIII concentrate and FFP in pre-, per- and postpartum. The same protocol was successfully used in a patient before dental extraction and prostatectomy. Vaginal delivery is possible, as our case. Management by multidisciplinary team is recommended.

A close insight to factor VIII inhibitor in the congenital hemophilia A.

Science.gov (United States)

Tabriznia-Tabrizi, Shamsoreza; Gholampour, Marzie; Mansouritorghabeh, Hassan

2016-09-01

Hemophilia A (HA) has an X-linked pattern of inheritance and is the most common of the hemorrhagic disorders. HA is caused by a decreased or deficiency of the functional clotting factor VIII (FVIII) and effects 1 in 5000-10,000 male births. The common treatment for hemophilia is replacement therapy by plasma-derived or recombinant FVIII. Approximately 20-30% of people with a severe type of HA develop an inhibitor and this phenomenon is the main challenge in the management of these patients. Genetic factors and environmental determinants contribute to inhibitor development. Here, the roles of various genetic and environmental factors such as the type of FVIII concentrate used, the number of exposure days, and peak treatment time will be discussed in detail. It seems this information is helpful for hematologists. A literature review was done in January 2016 on PubMed and Scopus using the following keywords:' h(a)emophilia A & factor VIII inhibitor', 'h(a)emophilia A & factor VIII alloantibody', 'h(a)emophilia A & inhibitor'. There was no time limitation; however, there was an English language limitation placed on the articles selected. Expert commentary: Influential genetic and environmental factors in developing inhibitors have been discussed. Most of the risk factors are related to previously untreated patients with hemophili.

Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A

Science.gov (United States)

Mahlangu, Johnny; Kuliczkowski, Kazimierz; Karim, Faraizah Abdul; Stasyshyn, Oleksandra; Kosinova, Marina V.; Lepatan, Lynda Mae; Skotnicki, Aleksander; Boggio, Lisa N.; Klamroth, Robert; Oldenburg, Johannes; Hellmann, Andrzej; Santagostino, Elena; Baker, Ross I.; Fischer, Kathelijn; Gill, Joan C.; P’Ng, Stephanie; Chowdary, Pratima; Escobar, Miguel A.; Khayat, Claudia Djambas; Rusen, Luminita; Bensen-Kennedy, Debra; Blackman, Nicole; Limsakun, Tharin; Veldman, Alex; St. Ledger, Katie

2016-01-01

Recombinant VIII (rVIII)-SingleChain is a novel B-domain–truncated recombinant factor VIII (rFVIII), comprised of covalently bonded factor VIII (FVIII) heavy and light chains. It was designed to have a higher binding affinity for von Willebrand factor (VWF). This phase 1/3 study investigated the efficacy and safety of rVIII-SingleChain in the treatment of bleeding episodes, routine prophylaxis, and surgical prophylaxis. Participants were ≥12 years of age, with severe hemophilia A (endogenous FVIII <1%). The participants were allocated by the investigator to receive rVIII-SingleChain in either an on-demand or prophylaxis regimen. Of the 175 patients meeting study eligibility criteria, 173 were treated with rVIII-SingleChain, prophylactically (N = 146) or on-demand (N = 27). The total cumulative exposure was 14 306 exposure days (EDs), with 120 participants reaching ≥50 EDs and 52 participants having ≥100 EDs. Hemostatic efficacy was rated by the investigator as excellent or good in 93.8% of the 835 bleeds treated and assessed. Across all prophylaxis regimens, the median annualized spontaneous bleeding rate was 0.00 (Q1, Q3: 0.0, 2.4) and the median overall annualized bleeding rate (ABR) was 1.14 (Q1, Q3: 0.0, 4.2). Surgical hemostasis was rated as excellent/good in 100% of major surgeries by the investigator. No participant developed FVIII inhibitors. In conclusion, rVIII-SingleChain is a novel rFVIII molecule showing excellent hemostatic efficacy in surgery and in the control of bleeding events, low ABR in patients on prophylaxis, and a favorable safety profile in this large clinical study. This trial was registered at www.clinicaltrials.gov as #NCT01486927. PMID:27330001

Efectos de cruzamiento para producción de leche y características de crecimiento en bovinos de doble propósito en el trópico húmedo

OpenAIRE

Sergio Iván Román-Ponce; Felipe de Jesús Ruiz-López; Hugo H. Montaldo; Rita Rizzi; Heriberto Román-Ponce

2013-01-01

Con el objetivo de evaluar los efectos de cruzamiento en tres subpoblaciones de ganado bovino cruzados de doble propósito en el trópico húmedo se utilizaron 5,040 lactancias y pesajes corporales al nacimiento [4,429] y pesos ajustados a 205 [3.878], 365 [3,017] y 540 [2,276] días (PN, P205, P365 y P540, respectivamente) de Cebú (CE) y sus cruzas con Holstein (HS), Suizo Pardo (SP) y Simmental (SM). Los efectos aditivos directos de raza (PG), heterocigocidad (HT) y pérdidas por recombinación (...

Performance of Angus, Devon and crossbred Angus x Devon x Nelore young steers in feedlot/ Desempenho de novilhos superprecoces Angus, Devon e cruzas Angus x Devon x Nelore em confinamento

Directory of Open Access Journals (Sweden)

Hélio Radke Bittencourt

2007-07-01

Full Text Available The study was based on data from 129 beef steers from three genetic groups: Angus (AN, n=45, Devon (DV, n=35 and Crossbred Angus x Devon x Nelore (CB, n=49, with an average beginning weight (ABWof 277.60, 278.00 and 295.53 kg, respectively. Those animals were in a feedlot with 11 months of age, to be slaughtered at 14 months. The parameters analyzed were: days on feed (DF, average weight gain (AWG, total weight gain (TWG, average slaughter weight (SW, average carcass weight (CW, average carcass yield (CY and carcass classification (CC. The analysis were done using the ABW as a covariate because of these variable in the group CB were higher (p0.05. CB animals got a higher SW (375.04 kg than DV (359.40 (p0.05. The CW (pForam analisados dados de 129 novilhos das raças Angus (AN, n=45, Devon (DV, n=35 e cruzas Angus x Devon x Nelore (CR, n=49, com peso médio inicial (PMI de 277,60, 278,00 e 295,53 kg, respectivamente, confinados aos 11 meses de idade para abate aos 14 meses. As variáveis-resposta mensuradas foram: tempo médio de permanência (TMP; ganho de peso médio diário (GMD; ganho de peso total (GP; peso médio ao abate (PMA; peso médio de carcaça (PC; rendimento médio de carcaça (RC e classificação de carcaça (CC. As análises foram realizadas utilizando o PMI como co-variável, visto que este foi maior (p 0,05. Animais CR apresentaram maior (p 0,05 de DV e CR. O PC (p < 0,05 e o RC (p < 0,01 foram maiores para CR (191,12 kg e 50,99% em relação à AN (179,81 kg e 49,73% e DV (177,23 kg e 49,41%, respectivamente, que não apresentaram variações significativas entre si. Novilhos Angus e Devon obtiveram resultados semelhantes em todas as variáveis analisadas. Animais cruza Angus x Devon x Nelore apresentaram maior peso e rendimento de carcaça do que animais puros.

Role of VI/II ratio on the growth of ZnO nanostructures using chemical bath deposition

Energy Technology Data Exchange (ETDEWEB)

Urgessa, Z.N., E-mail: zelalem.urgessa@nmmu.ac.za [Department of Physics, P.O. Box 77000, Nelson Mandela Metropolitan University, Port Elizabeth 6031 (South Africa); Oluwafemi, O.S. [Department of Chemistry and Chemical Technology, Walter Sisulu University, Mthatha Campus, Private Bag XI, 5117 (South Africa); Botha, J.R. [Department of Physics, P.O. Box 77000, Nelson Mandela Metropolitan University, Port Elizabeth 6031 (South Africa)

2012-05-15

In this paper the growth process and morphological evolution of ZnO nanostructures were investigated in a series of experiments using chemical bath deposition. The experimental results indicate that the morphological evolution depends on the reaction conditions, particularly on OH{sup -} to Zn{sup 2+} ratio (which directly affects the pH). For low VI/II ratios, quasi-spherical nanoparticles of an average diameter 30 nm are obtained, whereas for larger VI/II ratios, nanorods with an average diameter less than 100 nm are produced, which indicates that by systematically controlling the VI/II ratio, it is possible to produce different shapes and sizes of ZnO nanostructures. A possible mechanism for the nanostructural change of the as-synthesized ZnO from particle to rod was elucidated based on the relative densities of H{sup +} and OH{sup -} in the solution.

Role of VI/II ratio on the growth of ZnO nanostructures using chemical bath deposition

International Nuclear Information System (INIS)

Urgessa, Z.N.; Oluwafemi, O.S.; Botha, J.R.

2012-01-01

In this paper the growth process and morphological evolution of ZnO nanostructures were investigated in a series of experiments using chemical bath deposition. The experimental results indicate that the morphological evolution depends on the reaction conditions, particularly on OH − to Zn 2+ ratio (which directly affects the pH). For low VI/II ratios, quasi-spherical nanoparticles of an average diameter 30 nm are obtained, whereas for larger VI/II ratios, nanorods with an average diameter less than 100 nm are produced, which indicates that by systematically controlling the VI/II ratio, it is possible to produce different shapes and sizes of ZnO nanostructures. A possible mechanism for the nanostructural change of the as-synthesized ZnO from particle to rod was elucidated based on the relative densities of H + and OH − in the solution.

PENGEMBANGAN KARAKTER KEDISIPLINAN DAN KEMAMPUAN PEMECAHAN MASALAH MELALUI MODEL LAPS-HEURISTIK MATERI LINGKARAN KELAS-VIII

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Sri Wahyuni

2015-08-01

Full Text Available Tujuan penelitian ini adalah untuk mengetahui (1 apakah pembelajaran dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat mengembangkan karakter kedisiplinan peserta didik, (2 apakah pembelajaran dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat meningkatkan kemampuan pemecahan masalah peserta didik, (3 apakah kemampuan pemecahan masalah matematika peserta didik yang diajar dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat mencapai kriteria ketuntasan minimal yang ditentukan. Desain penelitian ini adalah kualitatif deskriptif, artinya menggambarkan atau mendeskripsikan kejadian-kejadian yang menjadi pusat perhatian secara kualitatif dan berdasar data kualitatif. Penentuan sumber data dalam penelitian ini menggunakan teknik purposive sampling, yaitu dipilih dengan pertimbangan dan tujuan tertentu. Data diperoleh dengan observasi, wawancara, dan tes yang kemudian dianalisis menggunakan analisis kualitatif dan analisis gain untuk mengukur peningkatan. Analisis kualitatif menunjukkan karakter kedisiplinan dan kemampuan pemecahan masalah peserta didik meningkat, serta kemampuan pemecahan masalah peserta didik mencapai KKM melalui model pembelajaran LAPS-Heuristik.

Chromosome VIII disomy influences the nonsense suppression efficiency and transition metal tolerance of the yeast Saccharomyces cerevisiae.

Science.gov (United States)

Zadorsky, S P; Sopova, Y V; Andreichuk, D Y; Startsev, V A; Medvedeva, V P; Inge-Vechtomov, S G

2015-06-01

The SUP35 gene of the yeast Saccharomyces cerevisiae encodes the translation termination factor eRF3. Mutations in this gene lead to the suppression of nonsense mutations and a number of other pleiotropic phenotypes, one of which is impaired chromosome segregation during cell division. Similar effects result from replacing the S. cerevisiae SUP35 gene with its orthologues. A number of genetic and epigenetic changes that occur in the sup35 background result in partial compensation for this suppressor effect. In this study we showed that in S. cerevisiae strains in which the SUP35 orthologue from the yeast Pichia methanolica replaces the S. cerevisiae SUP35 gene, chromosome VIII disomy results in decreased efficiency of nonsense suppression. This antisuppressor effect is not associated with decreased stop codon read-through. We identified SBP1, a gene that localizes to chromosome VIII, as a dosage-dependent antisuppressor that strongly contributes to the overall antisuppressor effect of chromosome VIII disomy. Disomy of chromosome VIII also leads to a change in the yeast strains' tolerance of a number of transition metal salts. Copyright © 2015 John Wiley & Sons, Ltd.

Progress toward inducing immunologic tolerance to factor VIII

OpenAIRE

Scott, David W.; Pratt, Kathleen P.; Miao, Carol H.

2013-01-01

A major problem in treating hemophilia A patients with therapeutic factor VIII (FVIII) is that 20% to 30% of these patients produce neutralizing anti-FVIII antibodies. These antibodies block (inhibit) the procoagulant function of FVIII and thus are termed “inhibitors.” The currently accepted clinical method to attempt to eliminate inhibitors is immune tolerance induction (ITI) via a protocol requiring intensive FVIII treatment until inhibitor titers drop. Although often successful, ITI is ext...

Fluid-phase immunoradiometric assay for the detection of qualitative abnormalities of factor VIII/von Willebrand factor in variants of von Willebrand's disease

International Nuclear Information System (INIS)

Girma, J.P.; Ardaillou, N.; Meyer, D.; Lavergne, J.M.; Larrieu, M.J.

1979-01-01

Antigenic reactivity of F.VIII/WF in variants of von Willebrand's disease (vWd) was studied with both fluid-phase and solid-phase immunoradiometric assays. Two different (rabbit and goat) 125 I-labeled specific antibodies against purified F.VIII/WF were used in both their divalent (lgG) and their monovalent (Fab fragment) forms. Dose-response curves obtained by reacting a constant amount of antibody with serial dilutions of plasmas from normal or homozygous vWd demonstrated the specificity of the test. The accuracy was significantly higher with 125 I-Fab fragments of goat anti-F.VIII/WF antiserum than intact goat lgG or rabbit lgG or Fab fragments. The significant decrease of the slope of the dose-response curves obtained with plasma from variants of vWd has been interpreted as due to the presence of abnormal F.VIII/WF molecules with decreased antigenic reactivity. A similar anomaly was found in cryosupernatant prepared from normal plasma, paralleling similarities demonstrated between variants of vWd and cryosupernatant. Results of experiments performed by reacting constant plasma dilutions from control or variants of vWd and varying concentrations of anti-F.VIII/WF Fab fragments (rabbit or goat) confirmed the decreased antigenic reactivity of variant F.VIII/WF

Glioneuronal Heterotopia Presenting As a Cerebellopontine angle Tumor of the cranial Nerve VIII, Case Report.

Science.gov (United States)

Peris-Celda, M; Giannini, C; Diehn, F E; Eckel, L J; Neff, B A; Van Gompel, J J

2018-04-03

Vestibular schwannomas and meningiomas account for the great majority of lesions arising in the cerebellopontine angle (CPA). In this report, we present a case of glioneuronal heterotopia, also known as glioneuronal hamartoma, arising from the VIII cranial nerve, which is an extremely uncommon lesion. Important radiologic and surgical aspects are reviewed, which may help in early recognition and intraoperative decision making when these lesions are encountered. A healthy 29-year-old female presented with intermittent right facial numbness. Magnetic resonance imaging (MRI) showed an incidental minimally enhancing cerebellopontine angle lesion on the right VII-VIII cranial nerve complex. The patient declined serial observation and opted for operative intervention for resection. Intraoperatively, the lesion resembled neural tissue and was continuous with the VIII cranial nerve. Pathological analysis demonstrated mature glioneuronal tissue consistent with hamartomatous brain tissue. The patient maintained normal hearing and facial nerve function after surgery. Radiologic, surgical and pathological characteristics are described. Ectopic glioneuronal tissue of the VIII cranial nerve is a rare non-neoplastic lesion, and should be considered in the differential diagnosis of unusual appearing intracanalicular and cerebellopontine angle lesions. The congenital and benign nature of this entity makes observation a valid option for these cases, although they are so infrequent that they are often presumptively managed as vestibular schwannomas. Attempts to radically resect these lesions may result in higher rates of hearing loss or facial palsy due to their continuity with the cranial nerves. Copyright © 2018 Elsevier Inc. All rights reserved.

Characterization of a thrombin cleavage site mutation (Arg 1689 to Cys) in the factor VIII gene of two unrelated patients with cross-reacting material-positive hemophilia A.

Science.gov (United States)

Arai, M; Higuchi, M; Antonarakis, S E; Kazazian, H H; Phillips, J A; Janco, R L; Hoyer, L W

1990-01-15

The molecular defect responsible for moderate and severe hemophilia A has been identified for two unrelated patients with the CRM-positive form of this disorder (factor VIII activity of 0.02 and 0.05 U/mL with factor VIII antigen of 0.87 and 2.20 U/mL). In both cases, the immunopurified dysfunctional factor VIII protein is abnormal, in that the 80 Kd light chain is not cleaved by thrombin at arginine-1689. The basis for this failure was identified by polymerase chain reaction amplification of exon 14 of the variant factor VIII genes and direct sequencing of the amplified products. In both cases, a single base substitution (C to T) was identified that produces an arginine to cysteine substitution at amino acid residue 1689. These data identify the molecular defects of the two identical factor VIII variant proteins. The dysfunctional factor VIII has been designated "Factor VIII-East Hartford," the residence of the patient in whom the defect was first identified.

Lacerations to Zones VIII and IX: It Is Not Just a Tendon Injury

Directory of Open Access Journals (Sweden)

Charla R. Fischer

2011-01-01

Full Text Available Extensor tendon injuries are widely believed to be straightforward problems that are relatively simple to manage. However, these injuries can be complex and demand a thorough understanding of anatomy to achieve the best functional outcomes. When lacerations occur in the forearm as in Zones VIII and IX injury, the repair of the extensor tendon and muscle, and posterior interosseous nerve (PIN is often challenging. A review of the literature shows little guidance and attention for these injuries. We present four patients with injuries to Zones VIII and IX as well as a review of surgical technique, postoperative rehabilitation, and pearls that may be of benefit to those managing these injuries.

PENGARUH KEMANDIRIAN BELAJAR DAN PENGGUNAAN UANG SAKU TERHADAP PRESTASI BELAJAR KOMPETENSI DASAR EKONOMI KELAS VII DAN VIII

OpenAIRE

Apri Dwi Astuti

2012-01-01

Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah ...

Estudo citofotométrico da expressão do marcador tumoral Fator VIII e fatores prognósticos no adenocarcinoma gástrico Cytophotometric study of the expression of the tumoral marker Factor VIII and prognostic factors in gastrci adenocarcinoma

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Mary Tossa Nakamura

2007-12-01

Full Text Available RACIONAL: No câncer gástrico, a incidência, o diagnóstico e as opções terapêuticas apresentaram melhorias nas últimas décadas, porém o prognóstico permanece reservado, especialmente devido à maioria dos pacientes procurarem recurso médico com tumores avançados, metastáticos ou cirurgicamente irressecáveis já no diagnóstico. Biologia molecular é área de conhecimento recente com grandes questionamentos a serem respondidos e a atualidade dos fatos científicos mostra que o caminho deverá ser através da identificação de marcadores tumorais. Os grandes avanços na área da informática aprimoraram a análise da imagem celular através da citofotometria de imagem que possibilita através da imunoistoquímica estudar a proliferação celular e a angiogênese que participa em diversos processos tumorais, sendo pesquisadas por vários marcadores. Atualmente estudos são realizados para demonstrar o valor prognóstico de suas expressões, contudo, no adenocarcinoma gástrico resultados têm sido divergentes e estudos escassos. OBJETIVOS: Identificar e quantificar citofotometricamente a expressão dos marcadores da angiogênese através do fator VIII no adenocarcinoma e comparar suas expressões com fa classificação de Bormann, profundidade de invasão tumoral, grau de diferenciação, envolvimento nodal, padrão histológico e idade. MÉTODOS: Foram estudados 21 pacientes com adenocarcinoma gástrico, identificados de 1998 a 2006. Para a detecção do Fator VIII foi realizada imunoistoquímica, com anticorpo policlonal para Fator VIII. Foi realizada análise citofotométrica informatizada pelo sistema SAMBA 4000. RESULTADOS: Dos 21 pacientes 61,90% eram do sexo masculino e 38,10% do feminino, com idade mediana de 65 anos e apenas um não marcou para o Fator VIII (95,24% de marcação. As médias dos índices de marcagem para o Fator VIII foram de 61,14% (desvio-padrão de 15,06, variando de 29,16 a 73,91. Tumores com classifica

Factor VIII and von Willebrand factor co-delivery by endothelial cells

NARCIS (Netherlands)

Bouwens, E.A.M.|info:eu-repo/dai/nl/314061894

2011-01-01

A defect in coagulation factor VIII (FVIII) results in the inherited bleeding disorder hemophilia A. Current treatment of hemophilia A is hampered by the need of frequent administration of costly FVIII products. Therefore gene therapy is an attractive alternative for protein replacement to treat

Historical intensity VIII earthquakes along the Rhone valley (Valais, Switzerland): primary and secondary effects

Energy Technology Data Exchange (ETDEWEB)

Fritsche, S.; Faeh, D.; Schwarz-Zanetti, G.

2012-06-15

In recent years the upper Rhone Valley has been one of the most intensively investigated regions by the Swiss Seismological Service. The high seismicity in the region encourages research in the seismological field and one main focus has been historical seismology. This report presents the state of the art of our historical investigations by giving an overview of the effects of four damaging earthquakes with intensity larger than VII, for which a fairly large number of documents could be found and analyzed. The overview includes the events of 1584 (Aigle, epicentral intensity VIII), 1755 (Brig, epicentral intensity VIII), 1855 (Visp, epicentral intensity VIII), and 1946 (Sierre, epicentral intensity VIII for the main shock and intensity VII for the largest aftershock). The paper focuses mainly on primary and secondary effects in the epicentral region, providing the key data and a general characterization of the event. Generally, primary effects such as the reaction of the population and impact on buildings took more focus in the past. Thus building damage is more frequently described in historic documents. However, we also found a number of sources describing secondary effects such as landslides, snow avalanches, and liquefaction. Since the sources may be useful, we include citations of these documents. The 1584 Aigle event, for example, produced exceptional movements in the Lake of Geneva, which can be explained by an expanded sub aquatic slide with resultant tsunami and seiche. The strongest of the aftershocks of the 1584 event triggered a destructive landslide covering the villages Corbeyrier and Yvorne, Vaud. All macroseismic data on the discussed events are accessible through the web page of the Swiss Seismological Service (http://www.seismo.ethz.ch). (authors)

Effects of Mg/Ga and V/III source ratios on hole concentration of N-polar (000\\bar{1}) p-type GaN grown by metalorganic vapor phase epitaxy

Science.gov (United States)

Nonoda, Ryohei; Shojiki, Kanako; Tanikawa, Tomoyuki; Kuboya, Shigeyuki; Katayama, Ryuji; Matsuoka, Takashi

2016-05-01

The effects of growth conditions such as Mg/Ga and V/III ratios on the properties of N-polar (000\\bar{1}) p-type GaN grown by metalorganic vapor phase epitaxy were studied. Photoluminescence spectra from Mg-doped GaN depended on Mg/Ga and V/III ratios. For the lightly doped samples, the band-to-acceptor emission was observed at 3.3 eV and its relative intensity decreased with increasing V/III ratio. For the heavily doped samples, the donor-acceptor pair emission was observed at 2.8 eV and its peak intensity monotonically decreased with V/III ratio. The hole concentration was maximum for the Mg/Ga ratio. This is the same tendency as in group-III polar (0001) growth. The V/III ratio also reduced the hole concentration. The higher V/III ratio reduced the concentration of residual donors such as oxygen by substituting nitrogen atoms. The surface became rougher with increasing V/III ratio and the hillock density increased.

Idiopathic factor VIII inhibitor autoantibody in a man presented after accident.

NARCIS (Netherlands)

Mansouritorghabeh, H.; Lak, M.; Heerde, W.L. van

2009-01-01

Acquired hemophilia A is a rare but severe autoimmune bleeding disorder caused by autoantibodies against factor VIII activity and is a potentially life-threatening hemorrhagic disorder. The incidence of acquired hemophilia A has been estimated as 1.48 cases per million per year. The overall rate of

Selección de progenitores de maíz para la obtención de semilla híbrida por pequeños agricultores

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Roberto Valdivia

2000-01-01

Full Text Available El costo creciente de semilla híbrida de maíz ha limitado la productividad del cultivo en México. Por eso, los agricultores tienden a sembrar híbridos de segunda generación para reducir costos. Una mejor opción es utilizar el modelo Productor-Experimentador en la decisión de sembrar semilla de cruzas intervarietales. El objetivo del estudio fue describir la experiencia que ha tenido un grupo de productores de Santa María del Oro, Nayarit, en la producción, utilización y mejoramiento de cruzas intervarietales de maíz. En 1996, los productores sembraron seis experimentos donde observaron que la cruza B840xC343 rindió mejor que nueve híbridos comerciales. Con esta motivación, en 1997/98, los agricultores produjeron 20 toneladas de semilla de ocho cruzas. Los rendimientos de semilla fueron de 2 a 3 t/ha, así la semilla fue distribuida en la comunidad a menos del 50% del costo del híbrido comercial. En 1998, se sembraron alrededor de 400 ha con su semilla producida y se evaluaron las ocho cruzas, en cuatro experimentos. Los resultados mostraron que las mejores cruzas fueron P3028xA7573 y C385xD880. La primera cruza mostró una heterosis promedio y sobre el mejor progenitor de 4,9% y 4.1%, respectivamente; mientras que la segunda, tuvo similarmente una heterosis del 30% sobre un progenitor. A partir de 1999, los progenitores de la mejor cruza se mejorarán mediante un sistema de selección recurrente recíproca de medios hermanos, dos años por ciclo

One-electron spectrum of Xe VIII

International Nuclear Information System (INIS)

Roberts, J.R.; Knystautas, E.J.; Sugar, J.

1979-01-01

The spectrum of Xe VIII has been observed in a theta-pinch discharge. New line identifications were made that determine the energies of the 6s, 7s, 6p, and 5f terms relative to the 5s 2 S ground state and confirm the previously known 5p and 5d terms. An independent system of levels derived from the observed 4f-ng (n = 5,6) transitions was found. Its position relative to the ground state is obtained from a predicted value for the 5g effective quantum number n*. From the ns series (n=5--7) a value for the ionization enegy of 105.91 +- 0.05 eV was derived

46 CFR 54.01-2 - Adoption of division 1 of section VIII of the ASME Boiler and Pressure Vessel Code.

Science.gov (United States)

2010-10-01

... Boiler and Pressure Vessel Code. 54.01-2 Section 54.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND... division 1 of section VIII of the ASME Boiler and Pressure Vessel Code. (a) Pressure vessels shall be designed, constructed, and inspected in accordance with section VIII of the ASME Boiler and Pressure Vessel...

Influence of Problem Based Learning on Critical Thinking Skills and Competence Class VIII SMPN 1 Gunuang Omeh, 2016/2017

Science.gov (United States)

Aswan, D. M.; Lufri, L.; Sumarmin, R.

2018-04-01

This research intends to determine the effect of Problem Based Learning models on students' critical thinking skills and competences. This study was a quasi-experimental research. The population of the study was the students of class VIII SMPN 1 Subdistrict Gunuang Omeh. Random sample selection is done by randomizing the class. Sample class that was chosen VIII3 as an experimental class given that treatment study based on problems and class VIII1 as control class that treatment usually given study. Instrument that used to consist of critical thinking test, cognitive tests, observation sheet of affective and psychomotor. Independent t-test and Mann Whitney U test was used for the analysis. Results showed that there was significant difference (sig competences.

Safety, efficacy and pharmacokinetics of rVIII-SingleChain in children with severe hemophilia A: results of a multicenter clinical trial.

Science.gov (United States)

Stasyshyn, O; Djambas Khayat, C; Iosava, G; Ong, J; Abdul Karim, F; Fischer, K; Veldman, A; Blackman, N; St Ledger, K; Pabinger, I

2017-04-01

Essentials rVIII-SingleChain is a novel recombinant factor VIII with covalently bonded heavy and light chains. Efficacy, safety and pharmacokinetics were studied in pediatric patients with severe hemophilia A. Across all prophylaxis regimens, the median annualized spontaneous bleeding rate was 0.00. rVIII-SingleChain showed excellent hemostatic efficacy and a favorable safety profile. Background rVIII-SingleChain is a novel B-domain truncated recombinant factor VIII (rFVIII) comprised of covalently bonded FVIII heavy and light chains, demonstrating a high binding affinity to von Willebrand factor. Objectives This phase III study investigated the safety, efficacy and pharmacokinetics of rVIII-SingleChain in previously treated pediatric patients hemophilia A. Patients/Methods Patients could be assigned to prophylaxis or on-demand therapy by the investigator. For patients assigned to prophylaxis, the treatment regimen and dose were based on the bleeding phenotype. For patients receiving on-demand therapy, dosing was guided by World Federation of Hemophilia recommendations. The primary endpoint was treatment success, defined as a rating of 'excellent' or 'good' on the investigator's clinical assessment of hemostatic efficacy for all treated bleeding events. Results The study enrolled 84 patients (0 to 50 EDs. In the 347 bleeds treated and evaluated by the investigator, hemostatic efficacy was rated as excellent or good in 96.3%. The median annualized spontaneous bleeding rate was 0.00 (Q1, Q3: 0.00, 2.20), and the median annualized bleeding rate was 3.69 (Q1, Q3: 0.00, 7.20) across all prophylaxis regimens. No participant developed an inhibitor. Conclusions rVIII-SingleChain is a novel rFVIII molecule showing excellent hemostatic efficacy and a favorable safety profile in a clinical study in children hemophilia A. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and

Chaos in long-term behavior of some Bianchi-type VIII models

Energy Technology Data Exchange (ETDEWEB)

Halpern, P

1987-01-01

The long-term behavior of Bianchi-type VIII models with three different types of stress-energy tensors are examined and compared. The vacuum model, a matter-filled model, and a model with an electromagnetic field are considered. In each case the existence of chaotic behavior and transitions to chaotic behavior are discussed.

Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII

Science.gov (United States)

Lozier, Jay N; Kloos, Mark T; Merricks, Elizabeth P; Lemoine, Nathaly; Whitford, Margaret H; Raymer, Robin A; Bellinger, Dwight A; Nichols, Timothy C

2016-01-01

Animals with hemophilia are models for gene therapy, factor replacement, and inhibitor development in humans. We have actively sought dogs with severe hemophilia A that have novel factor VIII mutations unlike the previously described factor VIII intron 22 inversion. A male Old English Sheepdog with recurrent soft-tissue hemorrhage and hemarthrosis was diagnosed with severe hemophilia A (factor VIII activity less than 1% of normal). We purified genomic DNA from this dog and ruled out the common intron 22 inversion; we then sequenced all 26 exons. Comparing the results with the normal canine factor VIII sequence revealed a C→T transition in exon 12 of the factor VIII gene that created a premature stop codon at amino acid 577 in the A2 domain of the protein. In addition, 2 previously described polymorphisms that do not cause hemophilia were present at amino acids 909 and 1184. The hemophilia mutation creates a new TaqI site that facilitates rapid genotyping of affected offspring by PCR and restriction endonuclease analyses. This mutation is analogous to the previously described human factor VIII mutation at Arg583, which likewise is a CpG dinucleotide transition causing a premature stop codon in exon 12. Thus far, despite extensive treatment with factor VIII, this dog has not developed neutralizing antibodies (‘inhibitors’) to the protein. This novel mutation in a dog gives rise to severe hemophilia A analogous to a mutation seen in humans. This model will be useful for studies of the treatment of hemophilia. PMID:27780008

Synthesis of dispersive iron or iron–silver nanoparticles on engineered capsid pVIII of M13 virus with electronegative terminal peptides

Energy Technology Data Exchange (ETDEWEB)

Zhang, Shuai; Nakano, Kazuhiko; Zhang, Shu-liang; Yu, Hui-min, E-mail: yuhm@tsinghua.edu.cn [Tsinghua University, Key Laboratory of Industrial Biocatalysis of the Ministry of Education, Department of Chemical Engineering (China)

2015-10-15

M13 is a filamentous Escherichia coli virus covered with five types of capsid proteins, in which pVIII with ∼2700 copies was around the cylindered surface and pIII with five copies located at one end of the phage particle. The pIII-engineered M13 phages with enhanced binding specificity toward Fe were screened after five rounds of biopanning, and the one containing ATPTVAMSLSPL peptide at pIII-terminus was selected for mediated synthesis of zero valent (ZV) Fe nanoparticles (NPs) with the wild M13 as control. Under a reducing environment, uniformly dispersed ZVFeNPs with diameter of 5–10 nm were both synthesized and the morphologies after annealing were confirmed to be face-centered cubic type. The synthesized FeNPs mediated by the two phages showed no significant difference, revealing that the pVIII capsid did dominant contribution to metal binding in comparison with the pIII. A novel pVIII-engineered M13 containing AAEEEDPAK at terminus, named as 4ED-pVIII-M13, was constructed and it carried one more negatively charged residue than the wild one (AEGDDPAK). Metal adsorption quantification showed that the binding affinity of the 4ED-pVIII-M13 toward Ag and Ni ions improved to 62 and 18 % from original 21 and 6 %, respectively. The binding affinity toward Fe remained constant (∼85 %). ZVFe–Ag bi-NPs were successfully synthesized through mediation of 4ED-pVIII-M13. Particularly, the Fe:Ag ratio in the bi-NPs was conveniently controlled through changing the molar concentration of FeCl{sub 2} and AgNO{sub 3} solution before reduction.

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

NARCIS (Netherlands)

van den Biggelaar, M.; Bouwens, E.A.M.; Kootstra, N.A.; Hebbel, R.P.; Voorberg, J.; Mertens, K.

2009-01-01

Background Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

NARCIS (Netherlands)

van den Biggelaar, Maartje; Bouwens, Eveline A. M.; Kootstra, Neeltje A.; Hebbel, Robert P.; Voorberg, Jan; Mertens, Koen

2009-01-01

Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this study, we

The Effect of Growth Temperature and V/III Flux Ratio of MOCVD Antimony Based Semiconductors on Growth Rate and Surface Morphology

Directory of Open Access Journals (Sweden)

Ramelan Ari Handono

2017-01-01

Full Text Available Epitaxial Alx Ga1-x Sb layers on GaSb and GaAs substrates have been grown by atmospheric pressure metalorganic chemical vapor deposition using TMAl, TMGa and TMSb. Nomarski microscope and a profiler were employed to examine the surface morphology and growth rate of the samples. We report the effect of growth temperature and V/III flux ratio on growth rate and surface morphology. Growth temperatures in the range of 520°C and 680°C and V/III ratios from 1 to 5 have been investigated. A growth rate activation energy of 0.73 eV was found. At low growth temperatures between 520 and 540°C, the surface morphology is poor due to antimonide precipitates associated with incomplete decomposition of the TMSb. For layers grown on GaAs at 580°C and 600°C with a V/III ratio of 3 a high quality surface morphology is typical, with a mirror-like surface and good composition control. It was found that a suitable growth temperature and V/III flux ratio was beneficial for producing good AlGaSb layers. Undoped AlGaSb grown at 580°C with a V/III flux ratio of 3 at the rate of 3.5 μm/hour shows p-type conductivity with smooth surface morphology

Living in a physical world VIII. Gravity and life in water

Indian Academy of Sciences (India)

2006-07-31

Jul 31, 2006 ... Home; Journals; Journal of Biosciences; Volume 31; Issue 3. Living in a physical world VIII. Gravity and life in water. Steven Vogel. Series Volume 31 Issue 3 September 2006 pp 309-322. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/031/03/0309-0322 ...

Absorption signatures of warm-hot gas at low redshift : Ne VIII

NARCIS (Netherlands)

Tepper-García, T

2013-01-01

At z {lt} 1 a large fraction of the baryons is thought to reside in diffuse gas that has been shock-heated to high temperatures (10$^{5}$-10$^{6}$ K). Absorption by the 770.41, 780.32 å doublet of Ne VIII in quasar spectra represents a unique tool to study this elusive warm-hot phase. We have

Factor VIII S373L: mutation at P1' site confers thrombin cleavage resistance, causing mild haemophilia A.

Science.gov (United States)

Johnson, D J; Pemberton, S; Acquila, M; Mori, P G; Tuddenham, E G; O'Brien, D P

1994-04-01

A novel CRM+ mutation, factor VIII position 373 serine to leucine substitution (FVIII 373-Leu) was identified during a survey of Factor VIII (FVIII) mutations. We have purified the variant protein from the patient's plasma in order to allow further characterisation of the molecule. The CRM+ plasma contained 120% Factor VIII antigen (FVIII:Ag) and 6% Factor VIII coagulant activity (FVIII:C). After purification the mutant FVIII was subjected to thrombin proteolysis, and was thereby activated 5.6-fold compared with 7-fold for wild type molecule. Subsequently, spontaneous inactivation of the mutant was much slower than noted for wild type FVIII. Western blot analysis using monoclonal antibodies demonstrated that thrombin cleavage of FVIII 373-Leu at positions 740 and 1689 were normal but that cleavage at position 372 was completely absent. Crystallographic coordinates of the active site of thrombin complexed to fibrinopeptide A were used to explore possible mechanistic reasons for the failure of thrombin to cleave the mutant FVIII at position 372. Steric hindrance between the mutant side chain and the side chain of the P1 residue was apparent. We conclude that the functional defect of FVIII 373-Leu results from the inability of thrombin to cleave the mutant at position 372-373, and propose that this is due to steric hindrance by the side chain of leucine 373, preventing correct formation of the enzyme substrate complex.

The new albumin-free recombinant factor VIII concentrates for treatment of hemophilia: do they represent an actual incremental improvement?

Science.gov (United States)

Josephson, Cassandra D; Abshire, Thomas

2004-07-01

The goal of eliminating the low levels of infectious disease risk from hemophilia treatment has resulted in the development of multiple generations of recombinant factor VIII (rFVIII) products. The ideal product should be devoid of human and animal proteins, which may transmit infectious agents. These products should also maintain molecular integrity, hemostatic efficacy, similar immunogenicity, and acceptable side effect profiles as compared to plasma-derived factor VIII. Currently available first-, second-, and third-generation rFVIII products include Recombinate; Kogenate FS/Helixate FS and ReFacto; and Advate, respectively. During the evolution of rFVIII products, either full-length or B-domain-deleted factor VIII were transfected into immortalized cell lines. The B-domain-deleted product, ReFacto, has resulted in an additional method to monitor factor VIII levels. The third-generation products offer the theoretical advantage of being produced without human and/or animal proteins. Upon initial introduction into the marketplace, the newer products have a higher cost. However, when analyzing historical trends, the prices of these products are almost equivalent to first-generation products within 3 years of licensure. Thus, the initial cost of the product may be a minimal issue in the medical decision process when selecting rFVIII replacement therapy.

Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

Indian Academy of Sciences (India)

In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the ... The self-bound state appears to be at ρ ... The observations suggest that the Hubble expansion of the Universe ... Taking motivation from.

PENGARUH KEMANDIRIAN BELAJAR DAN PENGGUNAAN UANG SAKU TERHADAP PRESTASI BELAJAR KOMPETENSI DASAR EKONOMI KELAS VII DAN VIII

Directory of Open Access Journals (Sweden)

Apri Dwi Astuti

2012-10-01

Full Text Available Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah semua siswa kelas VII dan VIII SMP Semesta Boarding School Semarang. Variabel penelitian ini adalah kemandirian belajar dan penggunaan uang saku sebagai variabel bebas, sedangkan untuk� variabel terikat adalah prestasi belajar kompetensi dasar ekonomi. Data diambil dengan metode wawancara, kuesioner dan dokumentasi guru. Analisis data menggunakan analisis regresi linear berganda.Berdasarkan penelitian secara simultan menunjukkan adanya pengaruh antara kemandirian belajar dan penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 51,3%. Secara parsial, pengaruh kemandirian belajar terhadap prestasi belajar kompetensi dasar ekonomi sebesar 66,2% dan pengaruh penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 62,5%.Berdasarkan hasil penelitian diatas disimpulkan bahwa kemandirian belajar dan penggunaan uang saku berpengaruh positif baik secara simultan maupun parsial terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta Boarding school semarang tahun pelajaran 2011/2012. Saran yang berkaitan dengan penelitian ini yaitu : 1 Sekolah disarankan untuk memberikan batasan siswa pulang ke rumah agar dapat membantu siswa beradaptasi dengan cepat dan mudah tinggal di asrama. 2 Orang tua disarankan untuk memberikan uang saku yang disesuaikan dengan kebutuhan siswa. 3 Siswa disarankan untuk meningkatkan kemandirian dalam aspek belajar terutama bagi mata pelajaran yang masih kurang dari

Leonor Plantagenet y la consolidación castellana en el reinado de Alfonso VIII

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Cerda, José Manuel

2012-12-01

Full Text Available The kingdom of Castile experienced a process of political and territorial consolidation between the death of Sancho III in 1158 and the Curia of Carrión de los Condes in 1188, leaving behind the troublesome minority of Alfonso VIII and the subordination to the kingdom of Leon, and thus becoming a dominant power within the peninsula, and one that achieved considerable success in the Reconquest. The following article is part of a biographical approach to Eleanor Plantagenet, queen consort of Alfonso VIII, and by means of a specifi c focus offers an analysis of the role played by the English queen in this process of political consolidation of Castile. As we approach the eighth centenary of her death, the life and work of this little-studied woman emerges as a testimony to the important diplomatic and cultural tasks assumed by queens in twelfth-century Europe.

Desde la muerte de Sancho III en 1158 a la Curia de Carrión de los Condes en 1188, el reino castellano experimentó una consolidación política y territorial que dejó atrás la problemática minoría de Alfonso VIII y la subordinación al reino de León, que lo constituyó en un poder dominante dentro de la península y que logró un avance importante en la empresa reconquistadora. El presente trabajo es parte de un acercamiento biográfico a Leonor Plantagenet, consorte de Alfonso VIII, y que por medio de un enfoque particular ofrece un análisis de la incidencia que tuvo la reina inglesa en este proceso de afianzamiento político de Castilla. En las vísperas del octavo centenario de su muerte, la vida y obra de esta mujer hasta ahora poco estudiada, surge como un testimonio importante a la labor diplomática y cultural que asumían las reinas en la Europa del siglo XII.

VIII Brazilian Meeting on Simulational Physics (BMSP)

International Nuclear Information System (INIS)

Branco, N. S.; Figueiredo, W.; Plascak, J. A.; Santos, M.

2016-01-01

This special issue includes invited and selected articles of the VIII Brazilian Meeting on Simulational Physics (BMSP), held in Florianópolis, Santa Catarina, Brazil, from 3rd to 8th August, 2015. This is the eighth such meeting, and the second one to have contributed papers published in Journal of Physics: Conference Series (the other was the VII BMSP). The previous meetings in the BMSP series took place in the mountains of Minas Gerais, in the region of the Brazilian Pantanal, and in the shores of Paraíba. Now, for the first time, the Meeting was held in Florianópolis, with its pleasing shores, the capital of Santa Catarina state. The VIII BMSP brought together about 50 researchers from all over the world for a vibrant and productive conference. As in the previous meetings, the talks and posters highlighted recent advances in applications, algorithms, and implementation of computer simulation methods for the study of condensed matter, materials, and out of equilibrium, quantum and biologically motivated systems. We are sure that this meeting series will continue to be an important occasion for people working in simulational physics to exchange ideas and discuss the state of the art of this always expanding field. We are very glad to put together this special issue, and are most appreciative of the efforts of the editors of the Journal of Physics: Conference Series for making this publication possible. We are grateful for the outstanding work of the Florianopolis team, for the financial support of the Brazilian agencies CAPES and CNPq, and of the Federal Universities UFPB and UFSC. At last, but not least, we would like to acknowledge all of the authors for their written submissions. (paper)

CARACTERIZACIÓN DE LA PRODUCCIÓN DE LECHE DE LA CONEJA CON ENFASIS EN LA SUPERVIVENCIA Y CRECIMIENTO DE LA CAMADA EN RAZAS NUEVA ZELANDA BLANCO Y CALIFORNIA

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Benjamin Gómez-Ramos

2010-10-01

Full Text Available El objetivo fue integrar los conocimientos sobre factores genéticos y ambientales que inciden en la producción de leche (PL de la coneja y su efecto en la supervivencia y crecimiento de la camada. Las investigaciones sugieren que la PL se relaciona con el crecimiento y supervivencia del gazapo durante las primeras tres semanas de vida. En cuanto a los aspectos genéticos, se ha estimado que existen diferencias en PL entre razas puras y sus cruzas, además de que el índice de herencia (h2 para PL en Nueva Zelanda Blanco, California y sus cruzas reciprocas es de 0.12%, lo cual establece un mayor efecto ambiental sobre PL. Al parecer la PL alcanza su máxima producción (219.6 g con 12 gazapos/camada y su pico de producción se alcanza al tercer parto y disminuye a partir del quinto parto. Sin embargo, la PL es determinada por: la condición fisiológica de la coneja -lactante-gestante (130 g/día o lactante-no gestante (141 g/día-; el número de pezones, conejas con 10 pezones produjeron 10% más leche que aquellas con 8; la temperatura ambiente, por cada grado centígrado por arriba de 20°C la PL disminuye 7.7 g/día. Los principales factores que influyen sobre la PL de la coneja no son atribuibles a esta. Por lo tanto, es importante controlar la naturaleza aleatoria de la mayoría de los factores no-genéticos que afectan a PL.

Complexation of the cesium cation with lithium ionophore VIII: extraction and DFT study

Czech Academy of Sciences Publication Activity Database

Makrlík, E.; Novák, Vít; Vaňura, P.; Bouř, Petr

2013-01-01

Roč. 298, č. 3 (2013), s. 2065-2068 ISSN 0236-5731 Institutional support: RVO:61388963 Keywords : cesium cation * lithium ionophore VIII * complexation * extraction and stability constants * water-nitrobenzene system * DFT calculations * structures Subject RIV: CB - Analytical Chemistry , Separation Impact factor: 1.415, year: 2013

The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces.

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Caileen M Brison

Full Text Available The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy for hemophilia A patients, or they may spontaneously arise in cases of acquired hemophilia. Porcine factor VIII is an effective therapeutic for hemophilia patients with inhibitor due to its low cross-reactivity; however, the molecular basis for this behavior is poorly understood. In this study, the X-ray crystal structure of the porcine factor VIII C2 domain was determined, and superposition of the human and porcine C2 domains demonstrates that most surface-exposed differences cluster on the face harboring the "non-classical" antibody epitopes. Furthermore, antibody-binding results illustrate that the "classical" 3E6 antibody can bind both the human and porcine C2 domains, although the inhibitory titer to human factor VIII is 41 Bethesda Units (BU/mg IgG versus 0.8 BU/mg IgG to porcine factor VIII, while the non-classical G99 antibody does not bind to the porcine C2 domain nor inhibit porcine factor VIII activity. Further structural analysis of differences between the electrostatic surface potentials suggest that the C2 domain binds to the negatively charged phospholipid surfaces of activated platelets primarily through the 3E6 epitope region. In contrast, the G99 face, which contains residue 2227, should be distal to the membrane surface. Phospholipid binding assays indicate that both porcine and human factor VIII C2 domains bind with comparable affinities, and the human K2227A and K2227E mutants bind to phospholipid surfaces with similar affinities as well. Lastly, the G99 IgG bound to PS-immobilized factor VIII C2 domain with an apparent dissociation constant of 15.5 nM, whereas 3E6 antibody binding to PS-bound C2 domain was not observed.

Structure and stability of hexa-aqua V(III) cations in vanadium redox flow battery electrolytes.

Science.gov (United States)

Vijayakumar, M; Li, Liyu; Nie, Zimin; Yang, Zhenguo; Hu, JianZhi

2012-08-07

The vanadium(III) cation structure in mixed acid based electrolyte solution from vanadium redox flow batteries is studied by (17)O and (35/37)Cl nuclear magnetic resonance (NMR) spectroscopy, electronic spectroscopy and density functional theory (DFT) based computational modelling. Both computational and experimental results reveal that the V(III) species can complex with counter anions (sulfate/chlorine) depending on the composition of its solvation sphere. By analyzing the powder precipitate it was found that the formation of sulfate complexed V(III) species is the crucial process in the precipitation reaction. The precipitation occurs through nucleation of neutral species formed through deprotonation and ion-pair formation process. However, the powder precipitate shows a multiphase nature which warrants multiple reaction pathways for precipitation reaction.

KEANEKARAGAMAN HYMENOPTERA PARASITOID PADA PERKEBUNAN KELAPA SAWIT PTPN VIII CINDALI, BOGOR

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Ichsan Luqmana Indra Putra

2016-09-01

Full Text Available Diversity of parasitic Hymenoptera in PTPN VIII oil palm plantation Cindali, Bogor. One group of important natural enemies in oil palm plantation is parasitic Hymenoptera. The purpose of this research is to know the diversity and fluctuation of parasitic Hymenoptera PTPN VIII Cindali oil palm plantation. This research was conducted in 6 blocks of oil palm in September 2014 – June 2015. There were 5 plots in every observation blocks 39.2 x 39.2 m in size, and used direct and indirect method. Direct method done by 5 plants in every plots was taken randomized to observed and taken the herbivore insects to reared until the parasitic Hymenoptera came out. Observation of cover crops conducted by 3 subplots determined diagonally in every plots 9.8 x 9.8 m in size and herbivore insects was observed and collected. Indirect methods used sweep net and yellow pan trap. The result of this research, 26 parasitic Hymenoptera families was found, with the Braconidae was the most morphospecies found and the most individual amount was Scelionidae. The abundance of parasitoid in every month fluctuated.

VIII International Meeting on Lorentzian Geometry

CERN Document Server

Flores, José; Palomo, Francisco; GeLoMa 2016; Lorentzian geometry and related topics

2017-01-01

This volume contains a collection of research papers and useful surveys by experts in the field which provide a representative picture of the current status of this fascinating area. Based on contributions from the VIII International Meeting on Lorentzian Geometry, held at the University of Málaga, Spain, this volume covers topics such as distinguished (maximal, trapped, null, spacelike, constant mean curvature, umbilical...) submanifolds, causal completion of spacetimes, stationary regions and horizons in spacetimes, solitons in semi-Riemannian manifolds, relation between Lorentzian and Finslerian geometries and the oscillator spacetime. In the last decades Lorentzian geometry has experienced a significant impulse, which has transformed it from just a mathematical tool for general relativity to a consolidated branch of differential geometry, interesting in and of itself. Nowadays, this field provides a framework where many different mathematical techniques arise with applications to multiple parts of mathem...

Expressão citofotométrica dos marcadores tumorais CD-34 e fator VIII no câncer de cólon

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Cacilda Joyce Ferreira da Silva Garcia

Full Text Available OBJETIVOS: Verificar a posssibilidade de quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII no câncer de cólon; verificar se existe superioridade entre um marcador e outro para estudo da angiogênese; verificar se há correlação na análise do índice de marcagem e a densidade óptica média nos marcadores utilizados. MÉTODOS: Dezessete casos de adenocarcinoma colorretal recuperados de blocos de parafina e confirmados pela hematoxilina-eosina, foram submetidos à coloração imunoistoquímica pelo método da estreptoavidina-biotina-peroxidase e utilizados os marcadores tumorais CD-34 e Fator VIII. Após este processo as lâminas foram submetidas à leitura no sistema Samba 4000® e avaliadas pelo software Immuno®. Os parâmetros estudados foram: índice de marcagem e densidade óptica, expressos por médias, medianas, valores mínimos, valores máximos e desvios-padrão, analisados estatisticamente. RESULTADOS: Para o marcador CD-34 não houve normalidade dos dados em relação ao índice de marcagem e houve para a densidade óptica. Para o Fator VIII, houve normalidade de dados em relação ao índice de marcagem e para a densidade óptica. CONCLUSÃO: Foi possível quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII através do índice de marcagem e da densidade óptica média; não houve diferença entre os marcadores em relação à média do índice de marcagem e da densidade óptica, não sendo possível definir superioridade entre um e outro; não foi observada tendência à correlação quando comparados densidade óptica e índice de marcagem do Fator VIII e do CD-34 isoladamente estudados; não houve correlação entre o índice de marcagem do Fator VIII quando comparado com o CD-34, bem como a densidade óptica do Fator VIII com o CD-34.

Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

Indian Academy of Sciences (India)

In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the context of general relativity are explored. To obtain deterministic solution of the Einstein's field equations, various techniques are adopted. The features of the obtained solution are discussed.

Safety and Efficacy of BAY 94-9027, a Prolonged-Half-Life Factor VIII

DEFF Research Database (Denmark)

Reding, M T; Ng, H J; Poulsen, Lone Hvitfeldt

2017-01-01

BACKGROUND: BAY 94-9027 is a B-domain-deleted prolonged-half-life recombinant factor VIII (FVIII) conjugates in a site-specific manner with polyethylene glycol. OBJECTIVE: Assess efficacy and safety of BAY 94-9027 for prophylaxis and treatment of bleeds in patients with severe hemophilia A PATIEN...

Keefektifan Experiential Learning Berbantuan Origami Terhadap Kemampuan Keruangan Siswa Kelas VIII

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Isnaeni Umi Machromah

2014-11-01

Full Text Available AbstrakPenelitian eksperimen ini bertujuan untuk mengetahui keefektifan pembelajaran Experiential Learning berbantuan origami terhadap kemampuan keruangan siswa dengan kualifikasi keefektifan yang telah ditentukan. Populasi yaitu siswa kelas VIII SMP Negeri 3 Colomadu tahun pelajaran 2012/2013. Sampel diambil secara simple random sampling. Hasil penelitian ini yaitu: (1 Uji proporsi ketuntasan belajar menunjukkan siswa kelompok eksperimen telah mencapai ketuntasan belajar; (2 Uji perbedaan dua rata-rata menghasilkan simpulan bahwa rata-rata hasil post-test kemam-puan keruangan siswa kelompok eksperimen lebih dari kelompok kontrol; (3 Analisis re-gresi menunjukkan bahwa motivasi belajar siswa memberikan pengaruh positif sebesar 49,3% terhadap kemampuan keruangan siswa; (4 Uji gain ternormalisasi menunjukkan terdapat peningkatan kemampuan keruangan siswa secara signifikan pada kategaori sedang untuk kelompok eksperimen dan kategori rendah untuk kelompok kontrol. Simpulan yang diperoleh yaitu Experiential Learning berbantuan origami efektif terhadap kemampuan keruangan siswa kelas VIII. AbstractThis experiment research aims to determine the effectiveness of Experiential Learning with Origami to the students’s spatial abilities by the criteria of effectiveness. The population of this research is students of grade VIII of SMP Negeri 3 Colomadu 2012/2013 academic year. Independent variables used in this research are learning by Experiential Learning with origami and student’s motivation. While the dependent variable is the student’s spatial abilities. This research is using documentation, spatial abilities’s test, dan motivation’s scale for collecting data method. Result of this research are: (1 proportion test show that the experiment group has reached mastering of learning clasically and personally; (2 result of spatial ablities’s post test in experiment group better than control group; (3 result of regretion shows that student�

Proteja a sus seres queridos de las quemaduras

Centers for Disease Control (CDC) Podcasts

Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres para ayudar a proteger a sus niños de las quemaduras, una de las principales causas de lesiones infantiles.

El folklore y sus paradojas

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HONORIO M. VELASCO MAILLO

1990-01-01

Full Text Available Uno de los rasgos más sobresalientes de la historia del folklore en España y otras naciones europeas son sus paradojas. Propuesto primero como ciencia ha llegado a ser claramente rechazado por posteriores ambientes científicos. Tendría interés hacer una historia social del folklore. Este artículo sugiere que tales paradojas y contradicciones están relacionadas con el paradigma científico que asumieron sus promotores, el evolucionismo cultural y con un concepto idealizado de "pueblo", que ayudaron a construir presentando colecciones de materiales. También analiza las diferentes funciones sociales que ha cumplido el discurso folklórico.

Proteja a sus seres queridos de un ahogamiento

Centers for Disease Control (CDC) Podcasts

Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de un ahogamiento, una de las principales causas de lesiones infantiles.

Neurotology findings in patients with diagnosis of vascular loop of cranial nerves VIII in magnetic resonance imaging

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Grocoske, Francisco Luiz Busato

Full Text Available Introduction: The vascular compression by redundant vessels under the VIII cranial nerves has been studied since the 80's, and many authors proposed correlations between the compression and the otoneurological findings (vertigo, tinnitus, hypoacusis, audiometry and electrophysiological findings. Objective: Analyze and correlate the different signs and otoneurological symptoms, the audiological findings and its incidence over individuals with Vascular Loop (VL diagnosis of VIII cranial nerves by magnetic resonance imaging (MRI. Method: Retrospective study through the analysis of medical records of 47 patients attended in the otoneurology clinic of Clinical Hospital of UFPR. All the patients have MRI exams with compatible pictures of VL of the VIII cranial nerves. Results: The tinnitus was the most frequent symptom, in 83% of the patients, followed by hypoacusis (60% and vertigo (36%. The audiometry presented alterations in 89%, the brainstem evoked auditory potential in 33% and the vecto-electronystagmography in 17% of the patients. Was not found statistically significant relation between the buzz or hypoacusis, and the presence of VL in MRI. Only 36% of patients had complaints of vertigo, the main symptom described in theory of vascular compression of the VIII pair of nerve. As in the audiometry and in brainstem evoked auditory potential was not found a statistically significant relation between the exam and the presence of the VL in the RMI. Conclusion: The results show independence between the findings of the RMI, clinical picture and audiological results (p>0,05 suggesting that there are no exclusive and direct relation between the diagnosis of vascular loop in the MRI and the clinical picture matching.

Valor preditivo da expressão dos anticorpos Antifator VIII no carcinoma epidermóide do esôfago Predictive value of antifactor VIII antibody expression in squamous cell carcinoma of the esophagus

Directory of Open Access Journals (Sweden)

Sebastião Gonzaga Barbosa-Neto

2007-12-01

Full Text Available RACIONAL: O carcinoma epidermóide do esôfago apresenta alta mortalidade, baixo índice de diagnóstico precoce e altos custos nos tratamentos, com resultados freqüentemente desapontadores e prognóstico sombrio. O melhor entendimento das técnicas de biologia molecular com citofotometria de imagem, permitiu avançar no conhecimento das alterações na expressão das proteínas desse câncer. OBJETIVOS: Quantificar a expressão das proteínas envolvidas na angiogênese e correlacioná-las com variáveis clínico-patológicas. MÉTODOS: Com o uso da técnica de imunoistoquímica, citofotometria de imagem pelo sistema SAMBA, foram analisadas 29 amostras de carcinoma epidermóide do esôfago incluídas em blocos de parafina. Critérios clínicos como idade, sexo e histopatológicos do grau de diferenciação tumoral, tamanho e localização do tumor foram analisados. Os parâmetros analisados foram o índice de marcagem e a densidade óptica. O marcador utilizado foi o anticorpo anti-Fator VIII. RESULTADOS: Foi possível verificar que as expressões médias do marcador no índice de marcagem foram maiores que as da densidade óptica. Fator VIII apresentou leituras homogêneas. O índice de marcagem foi de 80,17+/-10,40 com P=0,073 e a densidade óptica 51,25+/-11,02 com P=0,245. CONCLUSÃO: A análise quantificação da expressão das proteínas envolvidas na angiogênese permite definir subgrupos de acordo com a diferenciação do carcinoma, estágio tumoral, tamanho e localização do tumor, porém não associa-se com o sexo e a idade dos pacientes, e a densidade óptica do Fator VIII não tem expressão significativa em nenhum dos subgrupos analisados.BACKGROUND: Squamous cell carcinoma of the esophagus exhibits high mortality rate, rare precocious diagnosis, and expensive treatments, presenting frequently disappointed results and poor prognosis. The better understanding about Molecular Biology techniques using cytophotometric imaging allowed

Proteja a sus seres queridos de las intoxicaciones

Centers for Disease Control (CDC) Podcasts

Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de una intoxicación, una de las principales causas de lesiones infantiles.

Penggunaan Media Presentase Microsoft Power Point Untuk Meningkatkan Hasil Belajar IPS Terpadu Pada Siswa Kelas VIII a SMP Negeri 2 Tanantovea

OpenAIRE

Hitler, Ahmad

2014-01-01

Permasalahan yang diangkat dalam penelitian adalah apakah dengan penggunaan media Presentase Microsoft Power Point pada mata pembelajaran IPS Terpadu dapat meningkatkan hasil belajar siswa kelas VIII A di SMP Negeri 2 Tanantovea. Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa pada pokok bahasan Kolonialisme dan Imperialisme Barat di kelas VIII A SMP Negeri 2 Tanantovea. Penelitian ini dilakukan dalam 2 siklus, setiap siklus terdiri dari perencanaan, pelaksanaan tindakan, obs...

La estructura del fullereno C60 y sus aplicaciones

OpenAIRE

Vasilievna Kharissova, Oxana; Ortiz Méndez, Ubaldo

2002-01-01

Se revisan los datos reportados de una nueva clase de materiales basados en los fullerenos. Se explica la estructura del fullereno C60 y sus compuestos con metales alcalinos, sus propiedades y aplicaciones. Se señala que estos compuestos tienen propiedades de superconducción comparable con la de los tradicionales cupratos. Se indica que esta modificación del carbono puede formar nanotubos que tienen varias aplicaciones prácticas debido a sus propiedades.

Significantly improved surface morphology of N-polar GaN film grown on SiC substrate by the optimization of V/III ratio

Science.gov (United States)

Deng, Gaoqiang; Zhang, Yuantao; Yu, Ye; Yan, Long; Li, Pengchong; Han, Xu; Chen, Liang; Zhao, Degang; Du, Guotong

2018-04-01

In this paper, N-polar GaN films with different V/III ratios were grown on vicinal C-face SiC substrates by metalorganic chemical vapor deposition. During the growth of N-polar GaN film, the V/III ratio was controlled by adjusting the molar flow rate of ammonia while keeping the trimethylgallium flow rate unchanged. The influence of the V/III ratio on the surface morphology of N-polar GaN film has been studied. We find that the surface root mean square roughness of N-polar GaN film over an area of 20 × 20 μm2 can be reduced from 8.13 to 2.78 nm by optimization of the V/III ratio. Then, using the same growth conditions, N-polar InGaN/GaN multiple quantum wells (MQWs) light-emitting diodes (LEDs) were grown on the rough and the smooth N-polar GaN templates, respectively. Compared with the LED grown on the rough N-polar GaN template, dramatically improved interface sharpness and luminescence uniformity of the InGaN/GaN MQWs are achieved for the LED grown on the smooth N-polar GaN template.

Synthesization of the Ar VIII 3s-3p beam-foil decay curve

International Nuclear Information System (INIS)

Lindgaard, A.; Veje, E.

1981-01-01

The beam-foil decay curve for the 3s-3p transition in Ar VIII has been simulated from experimentally determined relative initial level populations and transition probabilities calculated in the numerical Coulomb approximation. Good agreement is observed between simulated and measured decay curves. A discussion of the simulation is given. (Auth.)

Haemophilia A: Database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene

Energy Technology Data Exchange (ETDEWEB)

Tuddenham, E.G.D. (Clinical Research Centre, Harrow (United Kingdom)); Cooper, D.N. (Thrombosis Research Inst., London (United Kingdom)); Gitschier, J. (Univ. of California, San Francisco (United States)); Higuchi, M.; Kazazian, H.H.; Antonarakis, S.E. (Johns Hopkins Univ., Baltimore (United States)); Hoyer, L.W. (American Red Cross, Rockville (United States)); Yoshioka, A. (Nara Medical Coll., Kashihara City (Japan)); Peake, I.R. (Royal Hallamshire Hospital, Sheffield (United Kingdom)); Schwaab, R. (Inst. fuer Klinische Biochemie der Univ. Bonn (West Germany)); Lavergne, J.M. (Hopital de Bicetre (France)); Giannelli, F. (Guy' s Hospital, London (United Kingdom))

1991-09-25

Mutations at the factor VIII gene locus causing Haemophilia A have now been identified in many patients from a many ethnic groups. Earlier studies used biased methods which detected repetitive mutations at a few CG dinucleotides. More recently rapid gene scanning methods have uncovered an extreme diversity of mutations. Over 80 different point mutations, 6 insertions, 7 small deletions, and 60 large deletions have been characterized. Repetitive mutation has been proved for at least 16 CpG sites. All nonsense mutations cause severe disease. Most missense mutations appear to cause instability of the protein, but some are associated with production of dysfunctional factor VIII molecules, thereby localizing functionally critical regions of the cofactor. Variable phenotype has been observed in association with three of the latter class of genotype. This catalogue of gene lesions in Haemophilia A will be updated annually.

Detection of Intracellular Factor VIII Protein in Peripheral Blood Mononuclear Cells by Flow Cytometry

Directory of Open Access Journals (Sweden)

Gouri Shankar Pandey

2013-01-01

Full Text Available Flow cytometry is widely used in cancer research for diagnosis, detection of minimal residual disease, as well as immune monitoring and profiling following immunotherapy. Detection of specific host proteins for diagnosis predominantly uses quantitative PCR and western blotting assays. In this study, we optimized a flow cytometry-based detection assay for Factor VIII protein in peripheral blood mononuclear cells (PBMCs. An indirect intracellular staining (ICS method was standardized using monoclonal antibodies to different domains of human Factor VIII protein. The FVIII protein expression level was estimated by calculating the mean and median fluorescence intensities (MFI values for each monoclonal antibody. ICS staining of transiently transfected cell lines supported the method's specificity. Intracellular FVIII protein expression was also detected by the monoclonal antibodies used in the study in PBMCs of five blood donors. In summary, our data suggest that intracellular FVIII detection in PBMCs of hemophilia A patients can be a rapid and reliable method to detect intracellular FVIII levels.

Analysis of factor VIII gene inversions in 164 unrelated hemophilia A families

Energy Technology Data Exchange (ETDEWEB)

Vnencak-Jones, L.; Phillips, J.A. III; Janco, R.L. [Vanderbilt Univ. School of Medicine, Nashville, TN (United States)] [and others

1994-09-01

Hemophilia A is an X-linked recessive disease with variable phenotype and both heterogeneous and wide spread mutations in the factor VIII (F8) gene. As a result, diagnostic carrier or prenatal testing often relies upon laborious DNA linkage analysis. Recently, inversion mutations resulting from an intrachromosomal recombination between DNA sequences in one of two A genes {approximately}500 kb upstream from the F8 gene and a homologous A gene in intron 22 of the F8 gene were identified and found in 45% of severe hemophiliacs. We have analyzed banked DNA collected since 1986 from affected males or obligate carrier females representing 164 unrelated hemophilia A families. The disease was sporadic in 37%, familial in 54% and in 10% of families incomplete information was given. A unique deletion was identified in 1/164, a normal pattern was observed in 110/164 (67%), and 53/164 (32%) families had inversion mutations with 43/53 (81%) involving the distal A gene (R3 pattern) and 10/53 (19%) involving the proximal A gene (R2 pattern). While 19% of all rearrangements were R2, in 35 families with severe disease (< 1% VIII:C activity) all 16 rearrangements seen were R3. In 18 families with the R3 pattern and known activities, 16 (89%) had levels < 1%, with the remaining 2 families having {le} 2.4% activity. Further, 18 referrals specifically noted the production of inhibitors and 8/18 (45%) had the R3 pattern. Our findings demonstrate that the R3 inversion mutation patterns is (1) only seen with VIII:C activity levels of {le} 2.4%, (2) seen in 46% of families with severe hemophilia, (3) seen in 45% of hemophiliacs known to have inhibitors, (4) not correlated with sporadic or familial disease and (5) not in disequilibrium with the Bcl I or Taq I intron 18 or ST14 polymorphisms. Finally, in families positive for an inversion mutation, direct testing offers a highly accurate and less expensive alternative to DNA linkage analysis.

Strategies for sustainable households. The SusHouse project

International Nuclear Information System (INIS)

Vergragt, Ph.J.; Knot, J.M.C.

2001-01-01

The international SusHouse project has developed a strategy design approach that can contribute to major (factor 20) efficiency improvements in household activities. Stakeholder workshops have been held to develop scenarios for a sustainable future (2050). These scenarios were evaluated on their economic consequences, environmental impacts and consumer acceptance. the results were then used as the input for a second round of stakeholder workshops, which aimed at developing short-term strategies and implementation plans. This Research Note reviews the SusHouse approach and its results. It ends with suggestions for further steps to be taken. A SusHouse CD-ROM is available, containing all final project reports as well as a scenario presentation in the form of images and short texts. 22 refs

Entre público y privado. El espacio colectivo en la vivienda moderna chilena: arquitectura y legislación

Directory of Open Access Journals (Sweden)

Umberto Bonomo Shakti Feuerhake

2017-07-01

Full Text Available Este artículo explora el surgimiento y la consolidación del espacio colectivo de uso común de los conjuntos de vivienda moderna en Chile. Se cruza el análisis morfológico a escala urbana de algunos conjuntos construidos en Santiago entre 1906 y 1959 con la mirada referida al ámbito legislativo habitacional, para dibujar la estrecha relación que existe entre ellos. El artículo concluye mostrando cómo las experiencias radicales de los años cincuenta y sesenta de Chile son el resultado de un profundo y complejo proceso de modernización del Estado y sus instituciones, de los avances disciplinares y de una nueva cultura metropolitana.

Influence Model Assisted Learning Cycle Mind Map to Achievement Physics Laboratory Judging from the performance Grade VIII SMPN 1 Rejoso Pasuruan

OpenAIRE

Ary Analisa Rahma

2014-01-01

Pengaruh Model Siklus Belajar Berbantuan Mind Map terhadap Prestasi Belajar Fisika Ditinjau dari Kinerja Laboratorium Siswa Kelas VIII SMPN 1 Rejoso Kabupaten Pasuruan Abstract: This study aimed to examine the effect of the learning cycle models aided the mind map on the learning achievement in terms of the performance of laboratory physics class VIII student on light material in SMP Negeri 1 Rejoso Pasuruan. This study is a quasi-experimental research. The research design used is a 2 x 2...

Proteja a sus seres queridos de las lesiones viales

Centers for Disease Control (CDC) Podcasts

Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de las lesiones viales, una de las principales causas de lesiones infantiles.

Proteja a sus seres queridos de las quemaduras

Centers for Disease Control (CDC) Podcasts

2008-12-10

Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres para ayudar a proteger a sus niños de las quemaduras, una de las principales causas de lesiones infantiles.  Created: 12/10/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/1/2009.

Proteja a sus seres queridos de un ahogamiento

Centers for Disease Control (CDC) Podcasts

2008-12-10

Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de un ahogamiento, una de las principales causas de lesiones infantiles.  Created: 12/10/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/1/2009.

Efeitos de humor no poema VIII de Catulo

Directory of Open Access Journals (Sweden)

Paulo Sérgio Vasconcellos

1997-12-01

Full Text Available Neste artigo apresenta-se uma contribuição ao estudo dos efeitos de humor no poema VIII de Catulo; de fato, além do metro dessa composição e de outros elementos criadores de distanciamento irônico que os estudiosos têm apontado, um outro aspecto de sua forma, ainda pouco percebido, guia a leitura para essa interpretação: o jogo, a maneira de anagrama imperfeito (o “hipograma”, ou, mais precisamente, “criptograma”, de Saussure, com os sons do nome da amada, aparentemente calado. E mais uma das maneiras com que o poeta elabora a jocosa diferença entre o que se diz e o que, sentido e reprimido, deixa-se, porém, transparecer.

Staining for factor VIII related antigen and Ulex europaeus agglutinin I (UEA-I) in 230 tumours. An assessment of their specificity for angiosarcoma and Kaposi's sarcoma.

Science.gov (United States)

Leader, M; Collins, M; Patel, J; Henry, K

1986-11-01

In this study we examined the staining reactivity of commercially available antisera to factor VIII related antigen (F VIII RAg) and Ulex europaeus agglutinin I (UEA-I) on sections from 230 formalin fixed paraffin embedded tumours. These included 196 sarcomas, 20 carcinomas and 14 angiomas. All angiomas showed positive staining for F VIII RAg; all carcinomas showed negative staining; the vasoformative areas of all angiosarcomas stained positively but only four of six angiosarcomas showed positive staining of their solid areas; of seven Kaposi's sarcomas, all showed positive staining of vessels and six showed positive staining of the spindle cell component. In the remaining 181 non-vascular sarcomas there was a false positive result in four tumours (2.2%), three of which had a history of irradiation. Pre-radiotherapy biopsies of these three tumours stained negatively with anti-F VIII RAg. UEA-I was demonstrated in all the angiomas studied, in all angiosarcomas (including the solid components) and in well-formed vessels of all Kaposi's sarcomas, but only in the spindle cell component of 3/6. However, there was an unacceptably high rate of false positive staining amongst the carcinomas and non-vascular sarcomas. In conclusion, F VIII RAg is a specific but not a sensitive marker of angiosarcomas; UEA-I is a sensitive but not a specific marker of angiosarcomas.

Proteja a sus seres queridos de las intoxicaciones

Centers for Disease Control (CDC) Podcasts

2008-12-10

Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de una intoxicación, una de las principales causas de lesiones infantiles.  Created: 12/10/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/1/2009.

Anterior Inferior Cerebellar Arteries Juxtaposed with the Internal Acoustic Meatus and Their Relationship to the Cranial Nerve VII/VIII Complex.

Science.gov (United States)

Alonso, Fernando; Kassem, Mohammad W; Iwanaga, Joe; Oskouian, Rod J; Loukas, Marios; Demerdash, Amin; Tubbs, R Shane

2017-08-16

Vascular loops in the cerebellopontine angle (CPA) and their relationship to cranial nerves have been used to explain neurological symptoms. The anterior inferior cerebellar artery (AICA) has variable branches producing vascular loops that can compress the facial cranial nerve (CN) VII and vestibulocochlear (CN VIII) nerves. AICA compression of the facial-vestibulocochlear nerve complex can lead to various clinical presentations, including hemifacial spasm (HFS), tinnitus, and hemiataxia. The formation of arterial loops inside or outside of the internal auditory meatus (IAM) can cause abutment or compression of CN VII and CN VIII. Twenty-five (50 sides) fresh adult cadavers underwent dissection of the cerebellopontine angle in the supine position. In regard to relationships between the AICA and the nerves of the facial/vestibulocochlear complex, 33 arteries (66%) traveled in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Five arteries (10%) traveled below the CN VII/VIII complex, six (12%) traveled posterior to the nerve complex, four (8%) formed a semi-circle around the upper half of the nerve complex, and two (4%) traveled between and partially separated the nervus intermedius and facial nerve proper. Our study found that the majority of AICA will travel in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Although the relationship between the AICA and porus acusticus and AICA and the nerves of the CN VII/VIII complex are variable, based on our findings, some themes exist. Surgeons should consider these with approaches to the cerebellopontine angle.

In vivo recovery and safety of human factor VIII product AAFACT in patients with haemophilia A

NARCIS (Netherlands)

Vossebeld, P. J. M.; Tissing, M. H.; van den Berg, H. M.; Leebeek, F. W. G.; de Goede-Bolder, A.; Novakova, I. R. O.; Gerrits, W. B. J.; Peters, M.; Koopman, M. M. W.; Faber, A.; Hiemstra, H.; Grob, P.; Strengers, P. F. W.

2003-01-01

AAFACT, a monoclonal purified, solvent/detergent treated human plasma-derived coagulation factor VIII concentrate obtained from plasma of voluntary, non-remunerated blood donors, is manufactured and marketed in the Netherlands by Sanquin Plasma Products since 1995. In a postmarketing surveillance

Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A

Science.gov (United States)

Sherman, Alexandra; Biswas, Moanaro; Herzog, Roland W.

2017-01-01

Hemophilia A (coagulation factor VIII deficiency) is a debilitating genetic disorder that is primarily treated with intravenous replacement therapy. Despite a variety of factor VIII protein formulations available, the risk of developing anti-dug antibodies (“inhibitors”) remains. Overall, 20–30% of patients with severe disease develop inhibitors. Current clinical immune tolerance induction protocols to eliminate inhibitors are not effective in all patients, and there are no prophylactic protocols to prevent the immune response. New experimental therapies, such as gene and cell therapies, show promising results in pre-clinical studies in animal models of hemophilia. Examples include hepatic gene transfer with viral vectors, genetically engineered regulatory T cells (Treg), in vivo Treg induction using immune modulatory drugs, and maternal antigen transfer. Furthermore, an oral tolerance protocol is being developed based on transgenic lettuce plants, which suppressed inhibitor formation in hemophilic mice and dogs. Hopefully, some of these innovative approaches will reduce the risk of and/or more effectively eliminate inhibitor formation in future treatment of hemophilia A. PMID:29225598

ewes

Directory of Open Access Journals (Sweden)

M. R. Dally

2004-01-01

Full Text Available Con el fin de determinar la tasa de ovulación, parición, tamaño de la camada y supervivencia embrionaria, 225 borregas de siete genotipos se examinaron mediante endoscopio 7-8 días después de su cruza. Como resultado se encontró que un mayor número de ovulaciones unilaterales sencillas y dobles procedieron del ovario derecho (P0.05. Por otra parte, no se encontró diferencia en la supervivencia embrionaria (P>0.01 al comparar entre ovulaciones sencillas, dobles y triples (69.8%, 76.0% y 63.0%, respectivamente ni entre las ovulaciones unilaterales y bilaterales. La línea cuatera Targhee seleccionada (TW produjo las camadas más numerosas (media = 2.0±1.4 mientras que el rebaño Targhee comercial produjo las menos numerosas. La línea ½ Targhee, ¼ Barbados, ¼ Dorset mostró la tasa de parición mayor (94%, seguida de la Polypay (87%, sin encontrarse diferencia (P>0.05 entre estas dos líneas. Se concluye que: el ovario derecho es más activo que el izquierdo en cuanto a la producción de óvulos, de entre los genotipos estudiados; las ovulaciones dobles fueron más frecuentes que las sencillas y triples, y la línea cuatera Targhee seleccionada produjo las camadas más numerosas en comparación con el hato comercial Targhee o sus cruzas.

Uma análise da progressividade do financiamento do Sistema Único de Saúde (SUS Analysis of the progressivity of Brazilian Unified National Health System (SUS financing

Directory of Open Access Journals (Sweden)

Maria Alicia Domínguez Ugá

2006-08-01

Full Text Available Este artigo analisa o grau de progressividade dos tributos que financiam o Sistema Único de Saúde (SUS. Nele são identificados os principais tributos que financiam o SUS e, com base nos microdados da Pesquisa de Orçamentos Familiares 2002-2003, é inferida a distribuição do ônus do pagamento dos tributos diretos e indiretos que financiam o SUS e analisado o grau de progressividade dos mesmos. Foi, ainda, calculado o índice de Kakwani do financiamento do SUS, que sintetiza o grau de progressividade de um sistema tributário. Os dados mostraram que o índice de Kakwani do financiamento público é de ­0,008 e que, portanto, o financiamento do SUS corresponde a um sistema quase proporcional, que onera proporcionalmente à renda. Em uma sociedade com o grau de desigualdade da brasileira, que exibe um índice de Gini de 0,57, ter um financiamento do SUS proporcional é fortemente questionável sob a ótica da justiça social: ao contrário, seria desejável construir bases de financiamento do SUS francamente progressivas, de forma a contra-restar a fortíssima concentração de renda da nossa sociedade.This article analyzes the level of progressivity in taxes financing the Brazilian Unified National Health System (SUS. Distribution of the tax burden financing the SUS was calculated using micro-data from the Household Budgets Survey, 2002-2003. The Kakwani index, which shows a tax system's level of progressivity, was calculated. The Kakwani index of public financing was -0.008, and SUS financing was nearly proportional to income. From a social justice perspective this is highly undesirable in a society like Brazil, with a Gini index of 0.57. The system should be clearly progressive in order to counterbalance the country's extreme income concentration.

PENGARUH PENGUASAAN KONSEP TEOREMA PYTHAGORAS TERHADAP KEMAMPUAN MENYELESAIKAN SOAL-SOAL BANGUN RUANG SISI DATAR PADA SISWA KELAS VIII MTS NEGERI BALANG-BALANG

Directory of Open Access Journals (Sweden)

Syahrida Zaerani

2017-12-01

Abstract: This study aims to determine the impact of the mastery of Pythagoras Theorem concepts on the ability of MTs Negeri Balang-Balang grade VIII students to solve polyhedron problems. This study is a quantitative research with ex post facto design. Statistical population consists of all grade VIII students in MTs Negeri Balang-Balang which was 204 students. The number of sampling used is 102 respondents taken by simple random sampling technique. The research instrument was a test related to Pythagorean an polyhedron problems. Descriptive and inferential statistics were performed as the statistical analysis. The descriptive analysis result shows that the mastery of Pythagoras Theorem concepts is within the category of ‘high’ and the ability of solving polyhedron problems is as well. The inferential statistical analysis using simple linear regression shows that there is an impact of the mastery of Pythagoras Theorem concepts on polyhedron problem solving ability of Grade VIII students of MTs Negeri Balang-Balang.

Lithium ionophore VIII as an extraordinarily effective receptor for the strontium cation: Experimental and theoretical study

Czech Academy of Sciences Publication Activity Database

Makrlík, E.; Novák, Vít; Vaňura, P.; Bouř, Petr

2014-01-01

Roč. 1061, Mar 5 (2014), s. 110-113 ISSN 0022-2860 Institutional support: RVO:61388963 Keywords : strontium cation * lithium ionophore VIII * complexation * extraction and stability constants * DFT calculations * structures Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.602, year: 2014

Improving attitudes toward mathematics learning with problem posing in class VIII

Science.gov (United States)

Vionita, Alfha; Purboningsih, Dyah

2017-08-01

This research is classroom action research which is collaborated to improve student's behavior toward math and mathematics learning at class VIII by using problem posing approach. The subject of research is all of students grade VIIIA which consist of 32 students. This research has been held on two period, first period is about 3 times meeting, and second period is about 4 times meeting. The instrument of this research is implementation of learning observation's guidance by using problem posing approach. Cycle test has been used to measure cognitive competence, and questionnaire to measure the students' behavior in mathematics learning process. The result of research shows the students' behavior has been improving after using problem posing approach. It is showed by the behavior's criteria of students that has increasing result from the average in first period to high in second period. Furthermore, the percentage of test result is also improve from 68,75% in first period to 78,13% in second period. On the other hand, the implementation of learning observation by using problem posing approach has also improving and it is showed by the average percentage of teacher's achievement in first period is 89,2% and student's achievement 85,8%. These results get increase in second period for both teacher and students' achievement which are 94,4% and 91,11%. As a result, students' behavior toward math learning process in class VIII has been improving by using problem posing approach.

ElecSus: Extension to arbitrary geometry magneto-optics

Science.gov (United States)

Keaveney, James; Adams, Charles S.; Hughes, Ifan G.

2018-03-01

We present a major update to ElecSus, a computer program and underlying model to calculate the electric susceptibility of an alkali-metal atomic vapour. Knowledge of the electric susceptibility of a medium is essential to predict its absorptive and dispersive properties. In this version we implement several changes which significantly extend the range of applications of ElecSus, the most important of which is support for non-axial magnetic fields (i.e. fields which are not aligned with the light propagation axis). Supporting this change requires a much more general approach to light propagation in the system, which we have now implemented. We exemplify many of these new applications by comparing ElecSus to experimental data. In addition, we have developed a graphical user interface front-end which makes the program much more accessible, and have improved on several other minor areas of the program structure.

Partial correction of a severe molecular defect in hemophilia A, because of errors during expression of the factor VIII gene

Energy Technology Data Exchange (ETDEWEB)

Young, M.; Antonarakis, S.E. [Univ. of Geneva (Switzerland); Inaba, Hiroshi [Tokyo Medical College (Japan)] [and others

1997-03-01

Although the molecular defect in patients in a Japanese family with mild to moderately severe hemophilia A was a deletion of a single nucleotide T within an A{sub 8}TA{sub 2} sequence of exon 14 of the factor VIII gene, the severity of the clinical phenotype did not correspond to that expected of a frameshift mutation. A small amount of functional factor VIII protein was detected in the patient`s plasma. Analysis of DNA and RNA molecules from normal and affected individuals and in vitro transcription/translation suggested a partial correction of the molecular defect, because of the following: (i) DNA replication/RNA transcription errors resulting in restoration of the reading frame and/or (ii) {open_quotes}ribosomal frameshifting{close_quotes} resulting in the production of normal factor VIII polypeptide and, thus, in a milder than expected hemophilia A. All of these mechanisms probably were promoted by the longer run of adenines, A{sub 10} instead of A{sub 8}TA{sub 2}, after the delT. Errors in the complex steps of gene expression therefore may partially correct a severe frameshift defect and ameliorate an expected severe phenotype. 36 refs., 6 figs.

Prospects and Challenges of Implementing the Hydrographic Region VIII Basin Plan

Directory of Open Access Journals (Sweden)

Nathalia Silva Duarte

2011-12-01

Full Text Available The current “National Water Law” states that water resources plans must be elaborated by basins, states, and for the country. This essay discusses the water management process considering federal and state legislations and their interrelations, for the purpose of elucidating the gaps found in them , aiming at their applicability to the system of water resources management within the CBH- Macaé and Ostras scope. It also discusses the construction and evolution process of the above-mentioned committee, and developments in the implementation of the Basin Plan of Hydrographic Region VIII.

Influence of V/III growth flux ratio on trap states in m-plane GaN grown by ammonia-based molecular beam epitaxy

International Nuclear Information System (INIS)

Zhang, Z.; Arehart, A. R.; Hurni, C. A.; Speck, J. S.; Ringel, S. A.

2012-01-01

Deep level transient spectroscopy (DLTS) and deep level optical spectroscopy (DLOS) were utilized to investigate the behavior of deep states in m-plane, n-type GaN grown by ammonia-based molecular beam epitaxy (NH 3 -MBE) as a function of systematically varied V/III growth flux ratios. Levels were detected at E C - 0.14 eV, E C - 0.21 eV, E C - 0.26 eV, E C - 0.62 eV, E C - 0.67 eV, E C - 2.65 eV, and E C - 3.31 eV, with the concentrations of several traps exhibiting systematic dependencies on V/III ratio. The DLTS spectra are dominated by traps at E C - 0.14 eV and E C - 0.67 eV, whose concentrations decreased monotonically with increasing V/III ratio and decreasing oxygen impurity concentration, and by a trap at E C - 0.21 eV that revealed no dependence of its concentration on growth conditions, suggestive of different physical origins. Higher concentrations of deeper trap states detected by DLOS with activation energies of E C - 2.65 eV and E C - 3.31 eV in each sample did not display measureable sensitivity to the intentionally varied V/III ratio, necessitating further study on reducing these deep traps through growth optimization for maximizing material quality of NH 3 -MBE grown m-plane GaN.

Thermo-mechanical treatment for improvement of superplasticity of SUS304; SUS304 no chososei kyodo kaizen no tame no kako netsu shori

Energy Technology Data Exchange (ETDEWEB)

Kato, M.; Torisaka, Y. [Mechanical Engineering Lab., Tokyo (Japan)

1998-01-25

Thermo-mechanical treatment was given to improve further the superplastic behavior of SUS 304 stainless steel. In the SUS 304, martensite phase produced by the processing induced transformation may be reversely transformed to the primary austenite phase by high-temperature heating. Crystal grain size is micronized to 1 {mu} m by combining this reverse transformation and recrystallization of the austenite phase. However, the straining rate at that time is as extremely low as 1 times 10 {sup -4}/s or lower, which is insufficient for an industrial material. Therefore, the SUS 304 processed as described above was given again a series of thermo-mechanical treatment of the similar forced cold processing and annealing to ultra-micronize the crystalline particles. Majority of the crystalline particles have come to have a grain size of several hundred nm. This test piece showed a total elongation of 400% or more at a test temperature of 973 K and a straining rate of 1.8 times 10 {sup -3}/s or lower. In addition, the straining rate sensitivity index `m` at that time was 0.45 or higher. The superplastic deformation of the SUS 304 has a high possibility of being governed by dynamic recrystallization. 4 refs., 7 figs., 1 tab.

Proteja a sus seres queridos de las lesiones viales

Centers for Disease Control (CDC) Podcasts

2008-12-10

Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de las lesiones viales, una de las principales causas de lesiones infantiles.  Created: 12/10/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/1/2009.

Obtenção e caracterização de anticorpo monoclonal murino anti-fator VIII da coagulação sangüínea Attainment and characterization of murine monoclonal anti-factor VIII antibodies

Directory of Open Access Journals (Sweden)

Rosana Rossi-Ferreira

2006-06-01

Full Text Available Entre os avanços da engenharia celular e biotecnologia nas últimas décadas, destaca-se a produção de anticorpos monoclonais murinos (AcMm utilizados no aprimoramento diagnóstico nas rotinas laboratoriais. A produção de fator VIII de alta pureza sempre foi o desejo e a preocupação das indústrias de hemoderivados para tratamento de pacientes portadores de hemofilia A, porém este produto inexiste no Brasil, sendo necessária sua obtenção no mercado internacional a custos elevados. O trabalho tem por objetivo a produção de AcMm anti-fator VIII humano (FVIII H através da expansão dos clones e caracterização imunoquímica do anticorpo. Camundongos Balb/c foram imunizados com FVIII H purificado como também proveniente de crioprecipitado e as células esplênicas dos animais foram fusionadas com células mielomatosas murinas segundo o método descrito por Kohler e Milstein para produção de híbridos em cultura. Foram testados 1.983 híbridos dos quais 105 foram submetidos à clonagem. Destes, 39 obtiveram monoclonalidade e 7 destes clones foram caracterizados através de técnicas de immunoblotting. Foram submetidas à purificação por cromatografia três imunoglobulinas de diferentes classes pertencentes aos clones LAMB1-10A1A4, LAMB1-17A1A1 e LAMB1-24A2A1. A imunoglobulina purificada pertencente ao clone LAMB1-10A1A4 foi adsorvida em coluna de imunoafinidade para purificação de concentrado de FVIII proveniente de crioprecipitado plasmático.Among the advances in cellular engineering and biotechnology over the last decades, the production of murine monoclonal antibodies (AcMm, used to improve laboratory diagnoses, stands out. The production of very pure factor VIII has always been a concern of suppliers of blood products to treat patients with hemophilia A and this product is still not produced in Brazil. Hence, it can only be attained on the international market at a high cost. The aim of this work was to produce AcMm anti

Structural Mimics of the [Fe]-Hydrogenase: A Complete Set for Group VIII Metals.

Science.gov (United States)

Barik, Chandan Kr; Ganguly, Rakesh; Li, Yongxin; Leong, Weng Kee

2018-06-18

A set of structural mimics of the [Fe]-hydrogenase active site comprising all the group VIII metals, viz., [M(2-NHC(O)C 5 H 4 N)(CO) 2 (2-S-C 5 H 4 N)], has been synthesized. They exist as a mixture of isomers in solution, and the relative stability of the isomers depends on the nature of the metal and the substituent at the 6-position of the pyridine ligand.

Genetic Variation of the SusC/SusD Homologs from a Polysaccharide Utilization Locus Underlies Divergent Fructan Specificities and Functional Adaptation in Bacteroides thetaiotaomicron Strains.

Science.gov (United States)

Joglekar, Payal; Sonnenburg, Erica D; Higginbottom, Steven K; Earle, Kristen A; Morland, Carl; Shapiro-Ward, Sarah; Bolam, David N; Sonnenburg, Justin L

2018-01-01

Genomic differences between gut-resident bacterial strains likely underlie significant interindividual variation in microbiome function. Traditional methods of determining community composition, such as 16S rRNA gene amplicon sequencing, fail to capture this functional diversity. Metagenomic approaches are a significant step forward in identifying strain-level sequence variants; however, given the current paucity of biochemical information, they too are limited to mainly low-resolution and incomplete functional predictions. Using genomic, biochemical, and molecular approaches, we identified differences in the fructan utilization profiles of two closely related Bacteroides thetaiotaomicron strains. B. thetaiotaomicron 8736 ( Bt-8736 ) contains a fructan polysaccharide utilization locus (PUL) with a divergent susC / susD homolog gene pair that enables it to utilize inulin, differentiating this strain from other characterized Bt strains. Transfer of the distinct pair of susC / susD genes from Bt-8736 into the noninulin using type strain B. thetaiotaomicron VPI-5482 resulted in inulin use by the recipient strain, Bt ( 8736-2 ). The presence of the divergent susC / susD gene pair alone enabled the hybrid Bt ( 8736-2 ) strain to outcompete the wild-type strain in vivo in mice fed an inulin diet. Further, we discovered that the susC / susD homolog gene pair facilitated import of inulin into the periplasm without surface predigestion by an endo-acting enzyme, possibly due to the short average chain length of inulin compared to many other polysaccharides. Our data builds upon recent reports of dietary polysaccharide utilization mechanisms found in members of the Bacteroides genus and demonstrates how the acquisition of two genes can alter the functionality and success of a strain within the gut. IMPORTANCE Dietary polysaccharides play a dominant role in shaping the composition and functionality of our gut microbiota. Dietary interventions using these m icrobiota- a

Santa Teresa y sus cartas, historia de los sentimientos

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Egido, Teófanes

2015-12-01

Full Text Available Historical reflection on a peculiar dimension of St. Teresa of Jesus: the expression of her feelings in her writings, particularly in her abundant letters. The article focuses on the sense of humor, the joyfulness, and the importance of laughter in St. Teresa language, and also on the feeling of endearment with her family, with her order, with fray Juan de la Cruz. Ample space is dedicated to the tenderness towards girls in her convents. St. Teresa of Jesus appears as transgressor of 16th century social behaviours.Reflexión histórica sobre una dimensión peculiar de santa Teresa de Jesús: la expresión de sus sentimientos en sus escritos, de forma más especial en sus cartas abundantes. El artículo se centra en el sentido del humor, de la alegría, en la importancia de la risa en el lenguaje de santa Teresa y en el sentimiento de ternura con su familia, con su orden, con fray Juan de la Cruz. Se dedica un espacio amplio a la ternura hacia las niñas en sus conventos. Aparece santa Teresa de Jesús como trasgresora de los comportamientos sociales del siglo XVI.

IMPLIKASI YURIDIS PUTUSAN MK NOMOR 46/PUU- VIII/ 2010 TERHADAP AKTA KELAHIRAN ANAK LUAR KAWIN

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Djumikasih Djumikasih

2014-08-01

Full Text Available Abstract This paper aims to identify and analyze what the juridical implications of the publication of the decision of the Constitutional Court No. 46/PUU-VIII / 2010 on Child Outside Marriage Deed which has been published by the Department of Population and Civil Registration prior to the establishment of the Constitutional Court's decision . The method used in this study is a normative juridical approach legislation. From the discussion, it can be concluded that the Constitutional Court 46/PUU-VIII/2010 Number of Tests on Article 43 paragraph ( 1 Marriage Act ( Act No. 1 of 1974 when viewed from the angle of legal certainty it will lead to legal certainty . But the decision will not have any juridical implications of the child's birth certificate that has been published outside of marriage and illegitimate child who was born before the date of February 17, 2012, as if enacted would be contrary to the principle of legality is interpreted Article 47 of the Law on the Constitutional Court and Article 28 ( i of the 1945 Constitution . Likewise, if the terms of the fairness and usefulness , especially for justice seekers / applicant , the timing of this decision is not fair and not useful , because although the Court granted the petition but the Constitutional Court can not be applied to her .   Key words: yuridical implication, birth certificate, children who are born outside of marriage   Abstrak   Tulisan ini bertujuan untuk mengetahui dan menganalisis apa implikasi yuridis dari terbitnya putusan MK Nomor 46/PUU-VIII/ 2010 terhadap Akta Anak Luar Kawin yang sudah diterbitkan oleh Dinas Kependudukan dan Catatan Sipil sebelum lahirnya putusan MK tersebut. Metode yang digunakan dalam penelitian ini adalah yuridis normative dengan pendekatan perundang-undangan. Dari pembahasan dapat disimpulkan bahwa Putusan MK Nomer 46/PUU-VIII/2010 tentang Pengujian terhadap Pasal 43 ayat (1 UU Perkawinan (UU NO 1 Tahun 1974 jika dilihat dari sudut kepastian

Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A

DEFF Research Database (Denmark)

Hvas, Anne-Mette; Sørensen, Hanne Thykjær; Norengaard, Lisbeth

2007-01-01

examined whether the clot stability in hemophiliacs could be improved by treatment with tranexamic acid (TXA) in combination with recombinant factor VIII (rFVIII). PATIENTS/METHODS: Baseline blood samples were obtained from eight males with severe hemophilia A. Thereafter, a bolus injection of r...

Hemophilia as a defect of the tissue factor pathway of blood coagulation: Effect of factors VIII and IX on factor X activation in a continuous-flow reactor

International Nuclear Information System (INIS)

Repke, D.; Gemmell, C.H.; Guha, A.; Turitto, V.T.; Nemerson, Y.; Broze, G.J. Jr.

1990-01-01

The effect of factors VIII and IX on the ability of the tissue factor-factor VIIa complex to activate factor X was studied in a continuous-flow tubular enzyme reactor. Tissue factor immobilized in a phospholipid bilayer on the inner surface of the tube was exposed to a perfusate containing factors VIIa, VIII, IX, and X flowing at a wall shear rate of 57, 300, or 1130 sec -1 . The addition of factors VIII and IX at their respective plasma concentrations resulted in a further 2 endash-to 3 endash fold increase. The direct activation of factor X by tissue factor-factor VIIa could be virtually eliminated by the lipoprotein-associated coagulation inhibitor. These results suggest that the tissue factor pathway, mediated through factors VIII and IX, produces significant levels of factor Xa even in the presence of an inhibitor of the tissue factor-factor VIIa complex; moreover, the activation is dependent on local shear conditions. These findings are consistent both with a model of blood coagulation in which initiation of the system results from tissue factor and with the bleeding observed in hemophilia

Visualizing the Life and Legacy of Henry VIII: Guiding Students with Eight Types of Graphic Organizers

Science.gov (United States)

Gallavan, Nancy P.; Kottler, Ellen

2010-01-01

Delving into the life and legacy of Henry VIII is both complex and captivating. People seem compelled to learn more abut his critical contributions and controversial conduct that range from the significant to the scandalous. Reflecting on the history of the world would be incomplete without investigating the events and escapades associated with…

Acquired factor VIII inhibitor syndrome: A rare cause of hematuria

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Muthuvel Seral Kannan

2015-01-01

Full Text Available A 50-year-old woman presented with gross hematuria for 1 month. Clinical examinations, laboratory investigations, ultrasound and contrast computed tomography were normal, except anemia. Cystoscopy revealed bloody efflux from the right side. Retrograde pyelogram showed filling defect in the renal pelvis and biopsy was inconclusive. Renal angiogram was normal. She developed ecchymosis on the right thigh and arm with elevated activated partial thromboplastin time. The partial thromboplastin time correction study and Bethesda study confirmed the presence of acquired factor VIII inhibitor (acquired hemophilia. With flexible ureterorenoscopy, the mass in the renal pelvis was removed and its histopathology revealed clotted blood. The patient was subsequently managed with steroids and Factor eight inhibitor bypass activity.

VIII All-Russian symposium on molecular liquid chromatography and capillary electrophoresis. Program. Summary of reports

International Nuclear Information System (INIS)

2001-01-01

Program and summary of reports of the VIII All-Russian symposium on molecular liquid chromatography and capillary electrophoresis are performed. The meeting took place 15-19 October, 2001 in Moscow. Many problems of liquid and ion exchange chromatography, capillary electrophoresis, thin-layer chromatography have been discussed extensively. Reports covering properties of sorbents and devices for chromatography are incorporated in the collection [ru

MENINGKATKAN AKTIVITAS BELAJAR SISWA DENGAN MENGGUNAKAN METODE GROUP INVESTIGATION (GI PADA POKOK BAHASAN PASAR DI KELAS VIII SMP 5 KUDUS

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Mutthofiyah Mutthofiyah

2016-03-01

Full Text Available Penelitian ini bertujuan untukmeningkatkan aktivitas belajar siswa dengan menggunakan metode group investigation (GI pada pokok bahasan pasar pada penelitian ini menggunakan penelitian tindakan kelas (PTK. Dalam penelitian ini dirancang menggunakan siklus, masing-masing siklus dengan tahapan perencanaan, pelaksanaan tindakan, observasi dan refleksi. Teknik pengumpulan data pada penelitian ini adalah dokumentasi, observasi dan tes.Hasil penelitian menunjukkan melalui meningkatkan metode group investigation (GI aktivitas siswa SMP 5 Kudus ada peningkatan yang sigifikan, dari siklus I kelas VIII F 15,8 (41,62% meningkat di siklus II menjadi 24,8 (72,9%, sedangkan di kelas VIII G siklus I 18,5 (47,04% meningkat menjadi 26,2 (74,7%; melalui penerapan metode group investigation hasil belajar siswa SMP 5 kudus meningkat sangat signifkan, ketuntasan belajar secara klasikal dari kelas VIII F pra siklus sebesar 17,64% terjadi peningkatan 47% ke siklus I dan meningkat menjadi 82,35% di siklus II. Sedangkan di kelas VII G pra siklus sebesar 22,85% meningkat 54,28% di siklus I dan meningkat menjadi 94,28% di siklus II. Saran yang peneliti berikan adalah sebagai berikut:1Kepada para guru diharapkan dapat menerapkan pembelajaran kooperatif khususnya pembelajaran kooperatif tipe Group Investigation (GI dalam proses pembelajaran ekonomi dan mata pelajaran lainya dan mengembangkannya; 2 Kepada para peneliti selanjutnya diharapkan dapat melakukan penelitian tentang penerapan model pembelajaran yang dapat membangkitkan keaktifan siswa untuk belajar ekonomi. This study aims to improve students' learning activities using group investigation (GI on the subject of markets in class VIII SMP 5 Kudus. In this study is designed to use cycles, with each cycle stages of planning, action, observation and reflection. Data collection techniques in this study is documentation, observation and tests. Results showed through improved methods of group investigation (GI junior 5 high

Isidore of Seville and comici ueteres. Ad Isid., Orig. VIII 7.7

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Krzysztof Rzepkowski

2012-12-01

Full Text Available In chapter 7 of book VIII of Etymologies dedicated to Roman poets (De poetis, Isidore draws a dividing line between the so-called ueteres and noui comici. Among ueteres he counts Plautus, Accius, Terentius, although Accius, according to our knowledge, composed only tragedies and can hardly be considered a comic playwright. In this paper I try to prove that all the palaeographic, phonetic, historical, and literary arguments speak in favour of emending in the discussed passage the peculiar «Accius» to the expected «Caecilius» (i.e. Caecilius Statius.

AKTIVITAS FISIK, ASUPAN ENERGI DAN STATUS GIZI WANITA PEMETIK TEH DI PTPN VIII BANDUNG, JAWA BARAT

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Venny Agustiani Mahardikawati

2012-03-01

Full Text Available 800x600 Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 Quality of human resources is very important to improve productivity. The worker productivity is correlated with nutritional status and health status. The objective of the research is to analyze physical activity, energy intake, nutritional status, of women workers at Tea Plantation PTPN VIII Bandung, West Java. The cross sectional design was used in this study to elaborate physical activity, nutritional status, and productivity of tea picker’s women. The criteria of study sample were tea picker’s women at cluster area of Malabar tea plantation of PTPN VIII Bandung, having infant and they were willing to be interviewed. The total number of 92 women sample was chosen randomly. Primary data consisted of physical activity recall (2x24 hours, food consumption recall (2x24 hours, anthropometry data (weight and height, and productivity (passage of tea sprout. Secondary data were included data of PT Perkebunan Nusantara VIII Bandung, West Java. The result showed that more than a half of samples having active or moderate physical activity level (PAL. The physical activity level of samples during work day (average PAL=1.87 was higher than holiday (average PAL=1.69 (p2362 kcal and 2134 kcal. The average energy adequacy level during workday and day off according to Schofield and Oxford equation were not significantly different, respectively 97,2% and 103,3%. The majority of samples had normal nutritional status, and 30.4% of the sample was overweight. The energy adequacy level according to Schofield and Oxford equation are related to nutritional status of women workers. Keywords: physical activity, energy expenditure, nutritional status, plantation women

Proteja a sus seres queridos de las caídas

Centers for Disease Control (CDC) Podcasts

Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de las caídas, una de las principales causas de lesiones infantiles.

Interiores y Hannah y sus hermanas: artistas y creadores en el cine de Woody Allen

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Francisco Casado Pérez

2015-01-01

Full Text Available Las reflexiones acerca del arte y las que tienen a los artistas que producen las obras como protagonistas son ejes fundamen- tales en la obra del cineasta neoyorquino Woody Allen. Mediante el estudio de dos de sus películas, Interiores y Hannah y sus hermanas, se analizan las diferentes actitudes de sus personajes al hacer frente a sus pulsiones creativas y cómo estas afectan a sus comportamientos en sociedad. En la primera, prácticamente todos los personajes proyectan en sus vidas sus insatisfacciones a la hora de desarrollar su arte, ya sea la escritura, la fotografía, la decoración, el cine o la interpretación. En la segunda, dos personajes, un pintor y un guionista televisivo, ofrecen más claves para dilucidar el amargo valor que da Allen a la labor artística.

Cuando el VIH se cruza en el camino del embarazo: dolor, incertidumbre y miedos

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Yurian Lida Rubiano Mesa

Full Text Available Recibir un diagnóstico de VIH durante la gestación es un evento traumático y que envuelve un proceso feliz y deseado, en uno doloroso, angustiante, lleno de miedos y medicalizado. También encierra a la mujer en un mar de incertidumbre por su futuro y el de su hijo. Este es el relato biográfico de una joven mujer que describe sus experiencias al enfrentarse al diagnóstico de VIH durante su primera gestación. A partir de este momento, su narrativa describe la discriminación y estigmatización por parte de los profesionales de la salud, la lucha diaria para tolerar los medicamentos y el miedo por la salud de su hija. Las implicaciones de la enfermedad en su vida como mujer y como madre también emergen en su relato, así como la fe en Dios, el apoyo de su madre y el amor hacia su hija como apoyos para enfrentar el VIH.

Molecular characterization of a novel family VIII esterase from burkholderia multivorans UWC10

CSIR Research Space (South Africa)

Rashamuse, KJ

2007-02-01

Full Text Available et al., 1992). Here we report the cloning, purification, and 3D model of a novel family VIII esterase from Burkholderia multivorans UWC10. To our knowledge no report of esterolytic activity from B. multivorans is currently available. METHODOLOGY... stream_source_info Rashamuse1_2007_d.pdf.txt stream_content_type text/plain stream_size 9884 Content-Encoding UTF-8 stream_name Rashamuse1_2007_d.pdf.txt Content-Type text/plain; charset=UTF-8 Molecular Characterization...

Pisanello’s hat. The costume and weapons depicted in Pisanello’s medal for John VIII Palaeologus. A discussion of the saber and related weapons

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Alexander, David

2004-12-01

Full Text Available A group of six drawings by the Veronese artist Antonio Pisano depicted the Bizantine Emperor John VIII Paleologus wearing costumes and weapons according to islamic types. This paper studies these objects in relation to other contemporary islamic weapons.

Un grupo de seis dibujos del artista veronés Antonio Pisano representa al emperador bizantino Juan VIII Paleólogo vestido y armado según modelos islámicos. Este trabajo estudia dichos objetos en relación a otras armas islámicas contemporáneas.

Altavoces y Sus Caracter?sticas.

OpenAIRE

Cabrera Ortiz, Juan Gabriel

2015-01-01

El contenido de aprendizaje aborda la definici?n de los altavoces desde el campo electroac?stico relacionando su principio de funcionamiento mec?nico el?ctrico y sus caracter?sticas mas importantes como lo son su tipo, respuesta en frecuencia, impedancia, sensibilidad y patr?n polar. Contenido realizado por el docente de la Escuela de Ciencias B?sicas Tecnolog?a e Ingenier?a Ing. Juan G. Cabrera O.

Penerapan Model Learning Cycle 5E untuk Meningkatkan Keterampilan Berpikir Kritis Siswa Pada Materi Fluida Statis Kelas VIII

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Irhamna Irhamna

2017-08-01

Full Text Available Penerapan model learning cycle 5E telah dilakukan pada siswa kelas VIII dengan materi fluida statis. Penelitian ini bertujuan untuk mendapatkan gambaran mengenai peningkatan keterampilan berpikir kritis siswa setelah diterapkan model learning cycle 5E pada materi fluida statis. Bentuk desain penelitian yang digunakan adalah pre-experimental dengan one group pre-test post-test design. Populasi pada penelitian ini adalah seluruh siswa kelas VIII di SMP Torsina Singkawang. Teknik pengambilan sampel menggunakan sampling purposive yang berjumlah 23 orang. Hasil penelitian menunjukkan bahwa model learning cyle 5E dapat meningkatkan keterampilan berpikir kritis siswa yaitu pada indikator pemecahan masalah dengan skor N-gain sebesar 0,43 dengan kategori sedang, indikator membuat keputusan dengan skor N-gain sebesar 0,42 dengan kategori sedang, indikator penyelidikan percobaan dengan skor N-gain sebesar 0,33 dengan kategori sedang dan indikator menyimpulkan dengan skor N-gain sebesar 0,37 dengan kategori sedang.

The influence of growth temperature and input V/III ratio on the initial nucleation and material properties of InN on GaN by MOCVD

International Nuclear Information System (INIS)

Wang, H; Jiang, D S; Zhu, J J; Zhao, D G; Liu, Z S; Wang, Y T; Zhang, S M; Yang, H

2009-01-01

The effects of growth temperature and V/III ratio on the InN initial nucleation of islands on the GaN (0 0 0 1) surface were investigated. It is found that InN nuclei density increases with decreasing growth temperature between 375 and 525 °C. At lower growth temperatures, InN thin films take the form of small and closely packed islands with diameters of less than 100 nm, whereas at elevated temperatures the InN islands can grow larger and well separated, approaching an equilibrium hexagonal shape due to enhanced surface diffusion of adatoms. At a given growth temperature of 500 °C, a controllable density and size of separated InN islands can be achieved by adjusting the V/III ratio. The larger islands lead to fewer defects when they are coalesced. Comparatively, the electrical properties of the films grown under higher V/III ratio are improved

Insight into resistance mechanism of anaplastic lymphoma kinase to alectinib and JH-VIII-157-02 caused by G1202R solvent front mutation

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Wang H

2018-05-01

Full Text Available Han Wang,1–3 Yao Wang,1–3 Wentao Guo,4 Bin Du,1–3 Xiaobing Huang,1–3 Riping Wu,1–3 Baoyu Yang,1–3 Xiaoyan Lin,1–3,5 Yilan Wu6 1Department of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 2Stem Cell Research Institute, Fujian Medical University, Fuzhou, People’s Republic of China; 3Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, People’s Republic of China; 4School of Pharmacy, Wenzhou Medical University, Wenzhou, People’s Republic of China; 5Graduate School of Education, Fujian Medical University, Fuzhou, People’s Republic of China; 6School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, People’s Republic of China Background: Mutated anaplastic lymphoma kinase (ALK drives the development of advanced non-small cell lung cancer (NSCLC. Most reported small-molecule inhibitors targeting the ALK domain do not display good inhibition of the G1202R solvent front mutation. The solvent front mutation was assumed to hinder drug binding. However, a different fact could be uncovered by the simulations reported in this study through a structural analog of alectinib (JH-VIII-157-02, which demonstrated potent effects against the G1202R mutation. Methods: Molecular docking, conventional molecular dynamics (MD simulations, free energy calculations, and umbrella sampling (US simulations were carried out to make clear the principles of the binding preferences of alectinib and JH-VIII-157-02 toward ALKWT and the ALK G1202R (ALKG1202R mutation. Results: JH-VIII-157-02 has similar binding affinities to both ALKWT and ALKG1202R whereas it has has a much lower binding affinity for alectinib to ALKG1202R. Analysis of individual energy terms indicate the major variation involves the van der Waals and entropy terms. Structural analysis reveals that the conformational change of the ATP-binding glycine-rich loop was primarily responsible for the alectinib

Grotrian diagrams for highly ionized cobalt Co VIII through Co XXVII

Energy Technology Data Exchange (ETDEWEB)

Shirai, Toshizo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Sugar, J.; Wiese, W.L.

1997-07-01

Grotrian diagrams are presented to provide graphical overviews for 1,247 spectral lines of highly ionized cobalt, Co VIII through Co XXVII. In the usual diagram display such as that by Bashkin and Stoner (North-Holland, Amsterdam, 1975), the density of transitions is often too high to allow each transition to be drawn separately. Here in our modified diagrams, the transitions are also represented by lines connecting the upper and lower energy levels, but the lower energy levels are extended and repeated for successive configurations as needed. As a sequence, dense packing is avoided and all lines in a multiplet can be accommodated. (author)

Comercio Internacional mediterráneo en el siglo VIII a.C.

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Paloma Cabrera Bonet

2018-01-01

Full Text Available The VIII century B.C. saw, for the first time after the breakdown of the system in the Late Bronze Age, the revival of a true intemational trade at a growing scale, especíally protagonized by Phoenicians and Greeks. In this article we analyze sorne aspects of this phenomenon, from the Aegean to the Far West, which made possíble, through a vaste network of trading routes, a large multinational ínteractíon. We understand the international trade as a key factor in the proccess of economic, social and political changes of the Mediterranean areas submerged in this complex "world-system".

The Safety and Feasibility of Three-Dimensional Visualization Technology Assisted Right Posterior Lobe Allied with Part of V and VIII Sectionectomy for Right Hepatic Malignancy Therapy.

Science.gov (United States)

Hu, Min; Hu, Haoyu; Cai, Wei; Mo, Zhikang; Xiang, Nan; Yang, Jian; Fang, Chihua

2018-05-01

Hepatectomy is the optimal method for liver cancer; the virtual liver resection based on three-dimensional visualization technology (3-DVT) could provide better preoperative strategy for surgeon. We aim to introduce right posterior lobe allied with part of V and VIII sectionectomy assisted by 3-DVT as a promising treatment for massive or multiple right hepatic malignancies to retain maximum residual liver volume on the basis of R0 resection. Among 126 consecutive patients who underwent hepatectomy, 9 (7%) underwent right posterior lobe allied with part of V and VIII sectionectomy. 21 (17%) underwent right hemihepatectomy (RH). The virtual RH was performed with 3-DVT, which provided better observation of spatial position relationship between tumor and vessels, and the more accurate estimation of the remnant liver volume. If remnant liver volume was right posterior lobe allied with part of V and VIII sectionectomy should be undergone. Then, the precut line ought to be planned on the basis of protecting the portal branch of subsegment 5 and 8. The postoperative outcome of patients was compared before and after propensity score matching. Nine patients meeting the eligibility criteria received right posterior lobe allied with part of V and VIII sectionectomy. The variables, including the overall mean operation time, blood transfusion, operation length, liver function, and postoperative complications, were similar between two groups before and after propensity matching. The postoperative first, third, fifth, and seventh days mean value of aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), and total bilirubin had no significant difference compared with preoperative value. One patient in each group had recurrence six months after surgery. Right posterior lobe allied with part of V and VIII sectionectomy based on 3-DVT is safe and feasible surgery way, and can be a very promising method in massive or multiple right hepatic malignancy therapy.

Analysis of inversions in the factor VIII gene in Spanish hemophilia A patients and families

Energy Technology Data Exchange (ETDEWEB)

Domenech, M.; Tizzano, E.; Baiget, M. [Hospital de Sant Pau, Barcelona (Spain); Altisent, C. [Hospital Vall d`Hebron, Barcelona (Spain)

1994-09-01

Intron 22 is the largest intron of the factor VIII gene and contains a CpG island from which two additional transcripts originate. One of these transcripts corresponds to the F8A gene which have telomeric extragenic copies in the X chromosome. An inversion involving homologous recombination between the intragenic and the distal or proximal copies of the F8A gene has been recently described as a common cause of severe hemophilia A (HA). We analyzed intron 22 rearrangements in 195 HA patients (123 familial and 72 sporadic cases). According to factor VIII levels, our sample was classified as severe in 114 cases, moderate in 29 cases and mild in 52 cases. An intron 22 (F8A) probe was hybridized to Southern blots of BcII digested DNA obtained from peripheral blood. A clear pattern of altered bands identifies distal or proximal inversions. We detected an abnormal pattern identifying an inversion in 49 (25%) of the analyzed cases. 43% of severe HA patients (49 cases) showed an inversion. As expected, no inversion was found in the moderate and mild group of patients. We found a high proportion (78%) of the distal rearrangement. From 49 identified inversions, 33 were found in familial cases (27%), while the remaining 15 were detected in sporadic patients (22%) in support that this mutational event occurs with a similar frequency in familial or sporadic cases. In addition, we detected a significant tendency of distal inversion to occur more frequently in familial cases than in sporadic cases. Inhibitor development to factor VIII was documented in approximately 1/3 of the patients with inversion. The identification of such a frequent molecular event in severe hemophilia A patients has been applied in our families to carrier and prenatal diagnosis, to determine the origin of the mutation in the sporadic cases and to detect the presence of germinal mosaicism.

Development of Integrated Natural Science Teaching Materials Webbed Type with Applying Discourse Analysis on Students Grade VIII in Physics Class

Science.gov (United States)

Sukariasih, Luh

2017-05-01

This study aims to produce teaching materials integrated natural science (IPA) webbed type of handout types are eligible for use in integrated science teaching. This type of research IS a kind of research and development / Research and Development (R & D) with reference to the 4D development model that is (define, design, develop, and disseminate). Data analysis techniques used to process data from the results of the assessment by the validator expert, and the results of the assessment by teachers and learners while testing is limited (12 students of class VIII SMPN 10 Kendari) using quantitative descriptive data analysis techniques disclosed in the distribution of scores on the scale of five categories grading scale that has been determined. The results of due diligence material gain votes validator material in the category of “very good” and “good”, of the data generated in the feasibility test presentation obtained the category of “good” and “excellent”, from the data generated in the feasibility of graphic test obtained the category of “very good “and” good “, as well as of the data generated in the test the feasibility of using words and language obtained the category of“very good “and” good “, so with qualifications gained the teaching materials IPA integrated type webbed by applying discourse analysis on the theme of energy and food for Junior High School (SMP) grade VIII suitable as teaching materials. In limited testing, data generated in response to a science teacher at SMPN 10 Kendari to product instructional materials as “excellent”, and from the data generated while testing is limited by the 12 students of class VIII SMPN 10 Kendari are more students who score indicates category “very good”, so that the qualification obtained by the natural science (IPA) teaching material integrated type webbed by applying discourse analysis on the theme of energy and food for SMP / class VIII fit for use as teaching material.

Low temperature grain boundary diffusion of chromium in SUS316 and 316L stainless steels

International Nuclear Information System (INIS)

Mizouchi, Masaki; Yamazaki, Yoshihiro; Iijima, Yoshiaki; Arioka, Koji

2004-01-01

Grain boundary diffusivity of chromium is SUS316 and 316L stainless steels has been determined in the temperature range between 518 and 1173 K. The magnitudes of the grain boundary diffusivities in four kinds of specimens are in the order of the cold-worked SUS316, the solution-treated SUS316L, the solution-treated SUS316 and the sensitized SUS316. The grain boundary diffusivities in these specimens are remarkably higher than those of previous works. The activation energies for the former are 85-91 kJmol -1 , whereas those for the latter are 151-234 kJmol -1 . (author)

El grafeno y sus propiedades especiales

OpenAIRE

F. Guinea

2011-01-01

El grafeno, formado por una capa de átomos de carbono, es un nuevo material con interesantes propiedades, desde un punto de vista fundamental, y también por sus posibles aplicaciones. Se describen algunas de estas propiedades, y se discuten algunos avances recientes en la investigación en este material.

Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models

OpenAIRE

Siner, Joshua I.; Samelson-Jones, Benjamin J.; Crudele, Julie M.; French, Robert A.; Lee, Benjamin J.; Zhou, Shanzhen; Merricks, Elizabeth; Raymer, Robin; Nichols, Timothy C.; Camire, Rodney M.; Arruda, Valder R.

2016-01-01

Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645–1648) in the design of B-domain–deleted FVIII (FVIII-BDD) products in current clinical use and in the drug development pipeline, as well as in experimental FVIII gene therapy strategies. Here, we report that processing by fu...

PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBANTUAN PEMETAAN PIKIRAN (MIND MAPPING TERHADAP KEMAMPUAN MENULIS TEKS BERITA SISWA KELAS VIII SMP NEGERI 1 PANTI

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Ricci Gemarni Tatalia, M.Pd

2017-05-01

Full Text Available This study was generated from the problem of students’ ability in writing news texts ini class VIII, SMPN 1 Panti. Some of the problem were (1 lack of the students’ response towards news writing teaching and learning process, (2 lack of teacher’s creativity in designing interesting news sriting learning model, (3 no appropriate creative techniques applied by the teacher which could train the students to develop their skill in writing news texts and (4 lack of the students’ motivation in participating in teaching and learning process because of their lack of understanding in the elements of news. Thus, this study was aimed at escribing the effect of the students’ ability ini writing news texts in class VIII SMP N 1 Panti. This was a quantitative research with factorial 2x2 experimental design. The population was the students in class VIII SMPN 1 Panti. Sampling technique was done by using random sampling and the data was collected through test. The result of the study revealed that cooperative learning model with STAD mind mapping type affected the students’ ability in writing news texts

A veces también llueve para arriba: de travestis, sus amores y desamores

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Luz Mary López Murcia

2010-10-01

estas, por un lado, se ubican en un orden heteronormativo del género y, por otro, legitiman y problematizan esta normatividad en sus modos de relacionarse consigo mismas y con los otros. En este texto se exponen algunos de los elementos que atraviesan la realidad de los travestis que ejercen la prostitución, a saber: la manera de construir sus identidades de género, sus nociones de la feminidad y la masculinidad, su cuerpo, sus concepciones sobre el amor y los roles que asumen y vivencian en las relaciones erótico-afectivas

An immunoradiometric assay for procoagulant factor VIII antigen: results in haemophilia, von Willebrand's disease and fetal plasma and serum

International Nuclear Information System (INIS)

Peake, I.R.; Bloom, A.L.; Giddings, J.C.; Ludlam, C.A.

1979-01-01

An immunoradiometric assay (IRMA) has been developed based on the inhibitor which arose in a polytransfused severe haemophiliac. The two-site IRMA measured antigens closely associated with the procoagulant parts of the factor VIII complex, which are termed FVIIIC antigens or FVIIICAG. FVIIICAG was present in normal plasma and also, at a slightly lower concentration, in normal serum. In 37 patients with haemophilia A, 36 had FVIIICAG levels of less than 10% of the normal plasma pool. In patients with von Willebrand's disease the levels of FVIIIC and FVIIICAG were in good agreement, both before and after treatment with cryoprecipitate or DDAVP. FVIIICAG was relatively stable in plasma at 37 0 C and could also be detected in cord and fetal serum. The assay is of potential value for detecting reduced levels of factor VIII, for carrier detection and for the prenatal diagnosis of haemophilia. (author)

Estudo da articulação temporomandibular em camundongos deficientes de fator VIII

OpenAIRE

Patricia do Socorro Queiroz Feio

2010-01-01

Resumo: A hemofilia é uma doença hemorrágica hereditária ligada ao cromossomo X, decorrente da ausência ou da baixa quantidade no plasma dos fatores de coagulação Fator VIII (hemofilia A) ou do Fator IX (hemofilia B). Clinicamente, a hemofilia se caracteriza por episódios recorrentes de sangramentos profundos, que podem ocorrer espontaneamente ou em decorrência de traumatismos. O sistema músculo-esquelético é freqüentemente afetado pelos eventos hemorrágicos nos pacientes portadores de hemofi...

An evaluation of designed Start-up System (SUS) for once-through steam generators

International Nuclear Information System (INIS)

Yu, Dali; Peng, Minjun; Xia, Genglei; Mao, Wanchao; Yang, Yang

2014-01-01

Highlights: • Four SUS solutions are established to help reactors complete the start-up process. • Solutions C and D lead to superior behaved than Solutions A and B. • Solution C is fit for propulsion reactors and Solution D for nuclear power reactors. - Abstract: In this paper, we report on research that has been carried out both on the comparison and evaluation of four designed Start-up Systems (SUSs), which are proposed to improve reliability and economy during the reactor start-up process. Firstly, four SUS solutions are established to satisfy demands and detailed descriptions are introduced. Then, four reactor systems, which include SUS, are modeled by the estimate code JTopmeret. Furthermore besides, the JTopmeret code is validated for the once-through steam generators (OTSG). Finally, the behaviors of SUS and the steady and transient performance of OTSG are investigated. The results show that the designed SUS can successfully improve the economy and the OTSG operational safety. Suggestion is made in this paper to apply Solution C in propulsion-purposed reactors, and Solution D in nuclear power reactors

EFFECT OF INFORMATION SERVICES USING THE MEDIA FILM TO SELF-CONFIDENCE STUDENT OF CLASS VIII SMP NEGERI 8 METRO

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MUDAIM MUDAIM

2015-06-01

Full Text Available Abstract: Pessimism and attitudes that consider themselves weak and does not have the ability when facing a problem will make individual impediment in the task of development. Problems confidence that underlies the research are: a Students are less confident in the ability it has, b Students feel pessimistic when faced with an issue, c Student perception subjectively, d Students still do not do the work independently, and e negative minded students with a state-owned. The problems of this study are whether there is an influence of information services using the medium of film to the confidence of eighth-grade students of SMP Negeri 8 Metro. The purpose of this study was to determine whether there is an influence of information services using the medium of film to the self-confidence of students in class VIII SMP Negeri 8 Metro. Subject participant is graders VIII-E total 30 students. Data were collected by questionnaire self-confidence and analyzed the data used is the t-test. The results of this study, shown by the difference in change scores of confidence from the pre-test and post-test of 17.1. Testing the hypothesis obtained calculation results thitung6,036> table = 1.699. The conclusion is that the information services implemented using the film medium can be a positive influence on self-esteem, especially students of class VIII. The advice given is to use the medium of film should be done intensively and more creative by BK teachers in giving information service. Keywords: Confidence, Service Information Using Media Film.

75 FR 36426 - Legislative Changes to Nursing Student Loan Program Authorized Under Title VIII of the Public...

Science.gov (United States)

2010-06-25

... Changes to Nursing Student Loan Program Authorized Under Title VIII of the Public Health Service Act....) 111-148. Section 5202 of the ACA changes the Nursing Student Loan (NSL) program by: (1) Increasing the... degree in nursing. Below are details on how the ACA changes Sections 836(a), 836(b)(1), and 836(b)(3) of...

Alternativas para favorecer la polinización y producción de semilla del híbrido h-311 de maíz

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Alejandro Espinosa

2001-01-01

Full Text Available Alternativas para favorecer la polinización y producción de semilla del híbrido H-311 de maíz. En la producción de semilla de híbridos de maíz es fundamental la coincidencia en floración de los progenitores y la disposición de los estigmas con respecto a las panojas que emiten polen. El híbrido de maíz H-311, se recomienda en México para siembras de riego, en alturas de 1200 a 1800 msnm. El orden de cruza inicial fue: (B16XB17 X (B32XB33; sin embargo, se cambio al orden inverso, es decir, (B32XB33 X (B16XB17, debido a mayor productividad y semilla de buena calidad física. La cruza simple (B16XB17 es enana (braquítico, al no haber suficiente viento en la época de polinización, se dificulta el cruzamiento y se requiere levantar el polen con mochilas de motor, la cruza simple B16XB17, rinde de 4,5 a 5,5 t/ha de semilla contra 6,0 a 7,5 t/ha de la cruza simple B32XB33; La cruza simple B16XB17, responde con alargamiento del porte por la influencia del tratamientos, con ácido giberélico (Activol, 20, 40 y 60 ppm, dos dosis de Cloruro de Mepiquat (PIX, 1 y 2 lt/ha, así como tres niveles de fertilización (400-70-30, 150-70-30 y 150- 300-30. En rendimiento hubo un efecto positivo por el manejo de ambos progenitores con diferentes fertilizaciones así como aplicación de fitohormonas, al aplicar ácido giberélico (20 ppm, el rendimiento se incrementó en 250,3% y 211,8% para las cruzas simples B32XB33 y B16XB17 respectivamente. La altura de planta de B16XB17 fue ligeramente afectada (106,0% con ácido giberélico, 40 ppm

Modifications to LLNL Plutonium Packaging Systems (PuPS) to achieve ASME VIII UW-13.2(d) Requirements for the DOE Standard 3013-00 Outer Can Weld

International Nuclear Information System (INIS)

Riley, D; Dodson, K

2001-01-01

The Lawrence Livermore National Laboratory (LLNL) Plutonium Packaging System (PuPS) prepares packages to meet the DOE Standard 3013 (Reference 1). The PuPS equipment was supplied by the British Nuclear Fuels Limited (BNFL). The DOE Standard 3013 requires that the welding of the Outer Can meets ASME Section VIII Division 1 (Reference 2). ASME Section VIII references to ASME Section IX (Reference 3) for most of the welding requirements, but UW-13.2 (d) of Section VIII requires a certain depth and width of the weld. In this document the UW-13.2(d) requirement is described as the (a+b)/2t s ratio. This ratio has to be greater than or equal to one to meet the requirements of UW-13.2(d). The Outer Can welds had not been meeting this requirement. Three methods are being followed to resolve this issue: (1) Modify the welding parameters to achieve the requirement, (2) Submit a weld case to ASME that changes the UW-13.2(d) requirement for their review and approval, and (3) Change the requirements in the DOE-STD-3013. Each of these methods are being pursued. This report addresses how the first method was addressed for the LLNL PuPS. The experimental work involved adjusting the Outer Can rotational speed and the power applied to the can. These adjustments resulted in being able to achieve the ASME VIII, UW-13.2(d) requirement

PENINGKATAN AKTIVITAS DAN HASIL BELAJAR POKOK BAHASAN PASAR DENGAN METODE RESITASI PADA SISWA KELAS VIII SMP NEGERI 24 SEMARANG TAHUN AJARAN 2013/2014

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Diinul Qoyyimah

2013-11-01

Full Text Available Aktivitas siswa kelas VIII pada mata pelajaran ekonomi SMP Negeri 24 Semarang pada pokok bahasan pasar masih rendah sehingga berdampak pada hasil belajar siswa yang masih dibawah KKM. Salah satu penyebabnya karena guru masih menerapkan metode belajar yang sama dalam waktu yang lama sehingga mengakibatkan rendahnya perolehan hasil belajar. Melalui penerapan metode ceramah bervariasi dan resitasi diharapkan siswa dapat belajar dengan santai dan senang dalam mengikuti proses pembelajaran. Penelitian ini bertujuan untuk mengetahui penerapan metode resitasi, dapat meningkatkan aktivitas dan hasil belajar siswa. Metode penelitian menggunakan penelitian tindakan kelas. Prosedur penelitian dilakukan dimulai dengan perencanaan, pelaksanaan, observasi dan refleksi. Metode pengumpulan data dengan dokumentasi dan tes. Hasil penelitian menyatakan bahwa ada peningkatan aktivitas siswa dan hasil belajar siswa materi pasar pada kelas VIII SMP Negeri 24 Semarang tahun 2013/2014. The students’ activity in VIII class of economic subject in SMP Negeri 24 Semarang in the subject matter of market topic is still low so it has the impact on the students’ learning outcome which is still under KKM requirements. One of the causes is because the teachers are still apply the same learning method in a long time so it resulted in low learning outcomes acquisition.through the application of various conventional methods and recitation are expected that students can learn easily and pleasure in participating of learning process. This study aims to determine the application of recitation method which can improve the activity and students’ learning outcomes. The research method using classroom action research. The research procedure begins with planning, implementation, observation and reflection. Methods of data collection carried out by documentation and test. The result of research states that there is an increasing activity and students’ learning outcomes in the

Design local exhaust ventilation on sieve machine at PT.Perkebunan Nusantara VIII Ciater using design for assembly (DFA) approach with Boothroyd and Dewhurst method

Science.gov (United States)

Khalqihi, K. I.; Rahayu, M.; Rendra, M.

2017-12-01

PT Perkebunan Nusantara VIII Ciater is a company produced black tea orthodox more or less 4 tons every day. At the production section, PT Perkebunan Nusantara VIII will use local exhaust ventilation specially at sortation area on sieve machine. To maintain the quality of the black tea orthodox, all machine must be scheduled for maintenance every once a month and takes time 2 hours in workhours, with additional local exhaust ventilation, it will increase time for maintenance process, if maintenance takes time more than 2 hours it will caused production process delayed. To support maintenance process in PT Perkebunan Nusantara VIII Ciater, designing local exhaust ventilation using design for assembly approach with Boothroyd and Dewhurst method, design for assembly approach is choosen to simplify maintenance process which required assembly process. There are 2 LEV designs for this research. Design 1 with 94 components, assembly time 647.88 seconds and assembly efficiency level 23.62%. Design 2 with 82 components, assembly time 567.84 seconds and assembly efficiency level 24.83%. Design 2 is choosen for this research based on DFA goals, minimum total part that use, optimization assembly time, and assembly efficiency level.

LAS MUJERES EN LA HISTORIA DE COLOMBIA, SUS DERECHOS, SUS DEBERES

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Jacqueline Blanco Blanco

2009-01-01

Full Text Available La igualdad de géneros ha estado sujeta a un largo proceso religioso, político, económico y social, en razón a los intereses que mueven a la sociedad masculina frente a la femenina. Lasmujeres, al principio de su historia, permanecieron sujetas a un código moral que no reconocía más que un incontable número de deberes, sin embargo, movida por sus razones de madre y esposa, principalmente, logró involucrarse en la toma de decisiones familiares, de donde pudo proyectarse hacia la participación y construcción de su núcleo familiar, de ahí contribuyó a labrar un camino en lo político y laboral que no le pudo ser indiferente por mucho tiempo.

Pengembangan Perangkat Pembelajaran Matematika Berbasis Problem Based Learning (PBL untuk Meningkatkan Kemampuan Pemecahan Masalah Peserta Didik Kelas VIII

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Rizza Yustianingsih

2017-09-01

Full Text Available Abstrak. Berdasarkan hasil penelitian pendahuluan pada kelas VIII SMP di lapangan, masih ditemukan kemampuan pemecahan masalah matematis siswa dalam masalah nyata yang belum optimal dan aktivitas siswa tidak mendukung proses belajar mereka. Salah satu faktornya adalah tidak cocoknya perangkat pembelajaran yang dapat memudahkan pembelajar untuk memperbaiki pemecahan kemampuan matematika dan kemampuan belajar siswa. Dari situ, untuk mendasari melakukan pengembangan perangkat pembelajaran matematika, ada rencana rencana pembelajaran (RPP dan lembar kerja siswa (LKPD berbasis Problem Based Learning (PBL, yang dapat memberikan pengalaman belajar untuk belajar pemecahan masalah dan dapat memberikan efek potensial yang baik pada aktivitas siswa selama proses belajar. Data dikumpulkan melalui observasi, kuesioner, wawancara, dan uji kemampuan pemecahan masalah. Subyek penelitian ini adalah siswa kelas VIII SMP N 3 Sawahlunto. Pengembangan penelitian ini yang digunakan adalah mode Plomp yang terdiri dari tahap awal penelitian, tahap prototipe, dan tahap penilaian. Berdasarkan hasil analisis data, terlihat bahwa alat pembelajaran berdasarkan PBL telah memenuhi kriteria yang valid dalam hal isi dan konstruksi. Peralatan pelajaran telah dianggap praktis dalam hal pelaksanaan dan efisiensi penggunaan waktu oleh guru dan siswa. Alat pelajaran juga efektif dalam hal proses penguasaan presentasi siswa belajar setelah menggunakan pembelajaran berbasis perangkat berbasis pembelajaran lebih besar dari atau sama dengan 75% sedangkan dalam hal hasil rata-rata siswa telah aktif dalam belajar. Kata kunci: Perangkat Pelajaran Matematika, Pemecahan Masalah, PBL.   Abstract. Based on the results of preliminary studies at grade VIII SMP in the field, it is still  found a mathematical problem solving ability of students in real problem who have not optimally and students activities do not support their learning process. One of the  factor is unsuitable of learning tools

Proteja a sus seres queridos de las caídas

Centers for Disease Control (CDC) Podcasts

2008-12-10

Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de las caídas, una de las principales causas de lesiones infantiles.  Created: 12/10/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/1/2009.

Morte neonatal precoce segundo complexidade hospitalar e rede SUS e não-SUS na Região Metropolitana de São Paulo, Brasil Early neonatal mortality according to level of hospital complexity in Greater Metropolitan São Paulo, Brazil

Directory of Open Access Journals (Sweden)

Zilda Pereira da Silva

2010-01-01

Full Text Available O objetivo foi analisar o perfil dos recém-nascidos, mães e mortalidade neonatal precoce, segundo complexidade do hospital e vínculo com o Sistema Único de Saúde (SUS, na Região Metropolitana de São Paulo, Brasil. Estudo baseado em dados de nascidos vivos, óbitos e cadastro de hospitais. Para obter a tipologia de complexidade e o perfil da clientela, empregaram-se análise fatorial e de clusters. O SUS atende mais recém-nascidos de risco e mães com baixa escolaridade, pré-natal insuficiente e adolescentes. A probabilidade de morte neonatal precoce foi 5,6‰ nascidos vivos (65% maior no SUS, sem diferenças por nível de complexidade do hospital, exceto nos de altíssima (SUS e média (não-SUS complexidade. O diferencial de mortalidade neonatal precoce entre as duas redes é menor no grupo de recém-nascidos 2.500g. Há uma concentração de nascimentos de alto risco na rede SUS, contudo a diferença de mortalidade neonatal precoce entre a rede SUS e não-SUS é menor nesse grupo de recém-nascidos. Novos estudos são necessários para compreender melhor a elevada mortalidade de recém-nascidos > 2.500g no SUS.The aim of this study was to analyze the profile of newborns, mothers, and early neonatal mortality according to the hospital's complexity and affiliation (or lack thereof with the Unified National Health System (SUS in Greater Metropolitan São Paulo, Brazil. The study was based on data for live births, deaths, and hospital registries. Factor and cluster analysis were used to obtain the typology of hospital complexity and user profile. The SUS treats more high-risk newborns and mothers with low schooling, insufficient prenatal care, and teenage mothers. The probability of early neonatal death was 5.6‰ live births (65% higher in the SUS, with no significant differences by level of hospital complexity, except those with extremely high (SUS and medium (non-SUS complexity. The difference in early neonatal mortality between the

Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A

NARCIS (Netherlands)

Collins, P. W.; Blanchette, V. S.; Fischer, K.; Bjorkman, S.; Oh, M.; Fritsch, S.; Schroth, P.; Spotts, G.; Astermark, J.; Ewenstein, B.

Background: The role of prophylactic factor VIII (FVIII) to decrease hemophilic bleeding and arthropathy is well established. The rationale for this strategy is to convert patients with severe hemophilia A to a moderate clinical phenotype by reducing time spent with a FVIII level <1 IU dL(-1).

Evaluation of the biological differences of canine and human factor VIII in gene delivery: Implications in human hemophilia treatment

Science.gov (United States)

The canine is the most important large animal model for testing novel hemophilia A(HA) treatment. It is often necessary to use canine factor VIII (cFIII) gene or protein for the evaluation of HA treatment in the canine model. However, the different biological properties between cFVIII and human FVII...

Libros españoles

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Helcías Martán Góngora

1968-10-01

Full Text Available El viaje a través de los libros depara sorpresas semejantes a las que la geografía regala al romero, que cruza por valles y montañas. Así puedo zarpar de la mano de El principito de Antoine de Saint-Exupery, demorarme por una Temporada en el infierno con J. A. Rimbaud, detener el paso ante El muro inicial de Jean Paul Sartre. Mas ahora debo asistir a la cita previa con El príncipe de este mundo, el ensayo medular de José María Souvirón, cuyo subtítulo: La literatura moderna y el demonio sitúa al lector ante un tema que si bien mueve a risa a los escépticos, involucra en sus páginas lo más representativo de la narrativa y la poesía contemporáneas.

Internal Stress Distribution Measurement of TIG Welded SUS304 Samples Using Neutron Diffraction Technique

Science.gov (United States)

Muslih, M. Refai; Sumirat, I.; Sairun; Purwanta

2008-03-01

The distribution of residual stress of SUS304 samples that were undergone TIG welding process with four different electric currents has been measured. The welding has been done in the middle part of the samples that was previously grooved by milling machine. Before they were welded the samples were annealed at 650 degree Celsius for one hour. The annealing process was done to eliminate residual stress generated by grooving process so that the residual stress within the samples was merely produced from welding process. The calculation of distribution of residual stress was carried out by measuring the strains within crystal planes of Fe(220) SUS304. Strain, Young modulus, and Poisson ratio of Fe(220) SUS304 were measured using DN1-M neutron diffractometer. Young modulus and Poisson ratio of Fe(220) SUS304 sample were measured in-situ. The result of calculations showed that distribution of residual stress of SUS304 in the vicinity of welded area is influenced both by treatments given at the samples-making process and by the electric current used during welding process.

Characteristics of SUS-MI cables and it's application to wiring in nuclear power facilities

International Nuclear Information System (INIS)

Okuno, Michio; Sato, Toshio; Handa, Katsue; Ohya, Shingo; Ioroi, Masaya

1984-01-01

SUS-MI cables are the inorganic insulation cables using austenitic stainless steel SUS 321 as the sheath, oxygen-free copper as the conductor and high purity magnesium oxide as the insulatingmaterial. Because of the excellent characteristics of the composing materials, the properties withstanding radiation, fire and heat, and sodium of the cables are superior. In the nuclear power facilities being developed such as fast breeder reactors and nuclear fusion reactors, there is the environment the cables with organic materials as the components cannot meet. As the cables to be applied to such places, the SUS-MI cables are most suitable. In this report, the electric properties and the mechanical strength of the cables and the examples of practical use are described. The highest temperature of using the SUS-MI cables is 800 deg C. The form and the composing materials of the SUS-MI cables, the characteristics and the cable laying are reported. Ceramic connectors and heat-resistant wall penetration parts were developed. The characteristics of the cables for the preheaters of fast breeder reactors are compared. (Kako, I.)

VIII Anuario de jóvenes investigadores

OpenAIRE

Bueno Delgado, María Víctoria; Carrillo Sánchez, José María; Díaz García, Miriam Cristina; González Reolid, Inocencio; Hidalgo Mompeán, Fernando; Izquierdo Zaragoza, José Luis; Legaz Aparicio, Alvar Ginés; Rosique Contreras, María Francisca; Sánchez Casado, Noelia; Sánchez Iborra, Ramón Jesús

2015-01-01

Pensamos que esta revista de publicación anual es una buena oportunidad para que los jóvenes investigadores puedan difundir sus actividades, aportando a la comunidad universitaria una panorámica de la investigación que se realiza en la UPCT. Las contribuciones deben ajustarse al formato típico de artículos originales, artículos de revisión, casos de estudio y/o del estado del arte. Deberán ser redactadas en español, con una longitud total de 3 páginas. Las instrucciones de estilo y formato...

Energies and lifetimes of excited states in copperlike Kr VIII

International Nuclear Information System (INIS)

Livingston, A.E.; Curtis, L.J.; Schectman, R.M.; Berry, H.G.

1980-01-01

The spectrum of Kr VIII has been observed between 180 and 2000 A by using foil excitation of 2.5--3.5-MeV krypton ions. Twenty new transitions have been classified and eleven new excited-state energies have been determined within the n=4 --7 shells. The ionization potential is derived to be 1 015 800 +- 200 cm -1 . The excited-state energies and fine structures are compared with recent relativistic Hartree-Fock calculations. The 4p-state lifetime has been measured by performing a simultaneous analysis of decay data for the 4p level and for its dominant cascade-repopulating levels. The 4p lifetime is found to be 30% shorter than previously measured values and is in excellent agreement with the result of a recent multiconfiguration Hartree-Fock calculation. The source of the discrepancy between this result and earlier measurements is discussed

Descripción de un inmunoensayo enzimático que reconoce anticuerpos anti-factor VIII/von Willebrand obtenidos a partir de hibridomas múridos Description of an enzime immunoassay that recognizes anti-factor VIII/von Willebrand antibodies obtained from murine hybridomas

Directory of Open Access Journals (Sweden)

Renée González Sampedro

1999-04-01

Full Text Available Se describe un inmunoensayo enzimático (ELISA que detecta anticuerpos anti-Factor-VIII/von Willebrand (FVIII/vW, con una relación de enlace > 5, que permite reconocer dichos anticuerpos tempranamente en los cultivos de hibridomas múridos. Para la adsorción de las placas del inmunoensayo se utilizaron preparados semipurificados de FVIII/vW obtenidos en Cuba. Se inmunizaron ratones Balb/c con la finalidad de generar los anticuerpos monoclonales detectados por este ELISA. Se obtuvo un clon con crecimiento estable y varios subclones positivos por el ELISA con actividad biológica específica de anticuerpos inhibidores de FVIIIAn enzime immunoassay (ELISA that detects anti-Factor VIII/von Willebrand (FVIII/vw antibodies with a binding relationship > 5 that allows the early recognition of such antibodies in the cultures of murine hybridomas is described. Semipurified preparations of FVIII/vw obtained in Cuba were used for the adsorption of the immunoassay plates. Balb/c mice were immunized in order to generate the monoclonal antibodies detected by this ELISA. A clone with stable growth and several positive subclones were obtained by ELISA with specific biological activity of FVIII-inhibiting antibodies

La industria francesa del cemento su evolución, sus tendencias

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Coiffu, Pierre

1961-06-01

Full Text Available Not availableSeñores: Habiéndome pedido mi querido amigo don Julián Rezola les expusiera a ustedes la evolución de la industria del cemento en la Franela Metropolitana, desde unos años acá, así como sus tendencias actuales, voy a tratar de corresponder de la mejor manera a esta invitación, que tanto me satisface como me honra. Empezaré por situar la industria francesa del cemento, indicando sus características principales, así como los factores que han influido en su evolución, para luego explicarles la manera de cómo los fabricantes han ido resolviendo los problemas que se les han presentado, y examinar sucesivamente la evolución de las diferentes secciones y servicios de una fábrica de cemento. Finalmente, voy a precisarles los resultados de conjunto obtenidos por nuestra industria, y trataré de darles algunas indicaciones sobre sus previsiones futuras.

Report on corrections and future considerations for Appendices II–VIII of the International Code of Nomenclature for Algae, Fungi, and Plants

Science.gov (United States)

For the first time, the main text and Appendices II–VIII of the International Code of Nomenclature were separately published following decisions of the Melbourne Nomenclature Section, which contributed to subsequent development of an online resource capable of producing the Appendices in real time. ...

X-ray spectral line coincidences between fluorine VIII (and IX) and transition metal lines

International Nuclear Information System (INIS)

Charatis, G.; Rockett, P.D.; Burkhalter, P.G.

1983-01-01

X-ray spectroscopy was performed in the 12 to 15 A region, recording L-shell lines from selected laser-irradiated transition metals. Line coincidences and near coincidences were identified between Fe, Cr, Mn, and Ni L-spectra, and F VIII and F IX K-shell lines. Wavelengths were determined to accuracies of 1 to 3 mA and will be utilized in selecting potential pumping candidates in future x-ray lasing schemes. High-resolution x-ray spectra were collected under controlled illumination and target conditions using 1.05 μm and 0.527 μm laser excitation with the KMS CHROMA laser

PENERAPAN MODEL PEMBELAJARAN BAKULIKAN UNTUK MENINGKATKAN KEMAMPUAN BERSIKAP ILMIAH PADA KONSEP PEMANTULAN CAHAYA KELAS VIII

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N. A. Shofiah

2012-01-01

Full Text Available Penelitian tindakan kelas yang bertujuan untuk meningkatkan kemampuan bersikap ilmiah, telah dilakukan di kelas VIII semester IIpada sub pokok bahasan pemantulan cahaya. Untuk meningkatkan kemampuan bersikap ilmiah diterapkan model pembelajaranbakulikan. Penelitian tindakan kelas ini terdiri dari tiga sikus, dengan masing-masing siklus terdiri dari empat tahapan yaituperencanaan, pelaksanaan, observasi dan refleksi. Data sikap ilmiah siswa diambil dari lembar angket dan lembar observasi. Datahasil belajar kognitif diambil dari evaluasi yang ada di LKS tiap akhir siklus dan data hasil belajar psikomotorik diambil dari lembarobservasi tiap akhir siklus. Hasil penelitian menyatakan bahwa sikap ilmiah siswa mengalami peningkatan walaupun tidaksignifikan. Hasil belajar kognitif dan keterampilan psikomotorik siswa mengalami peningkatan tiap siklus dan mencapai ketuntasanpada siklus III. A classroom action research aimed to improve scientific attitude skill had been done in second semester of grade VIII MTs on thesubtopic light reflection. The 'bakulikan' learning model was chosen for improving the scientific attitude skills of the students. Thisaction research consisted of three cycles, and each cycle has four stages, namely, planning, conducting, observation andreflection. The data obtained through questionnaire and observation sheets. The cognitive achievement drawn from the evaluationon each worksheet at the end of each cycle, and the psychometrics recorded from observation sheet. The study concludes that thescientific attitude skill improved significantly. The achievement on cognitive and psychometrics increase gradually on each cycleand get mastery at the end of the last cycle.Keywords: bakulikan; classroom action research; scientific attitude

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Science.gov (United States)

Dumont, Jennifer A.; Liu, Tongyao; Low, Susan C.; Zhang, Xin; Kamphaus, George; Sakorafas, Paul; Fraley, Cara; Drager, Douglas; Reidy, Thomas; McCue, Justin; Franck, Helen W. G.; Merricks, Elizabeth P.; Nichols, Timothy C.; Bitonti, Alan J.; Pierce, Glenn F.

2012-01-01

Despite proven benefits, prophylactic treatment for hemophilia A is hampered by the short half-life of factor VIII. A recombinant factor VIII-Fc fusion protein (rFVIIIFc) was constructed to determine the potential for reduced frequency of dosing. rFVIIIFc has an ∼ 2-fold longer half-life than rFVIII in hemophilia A (HemA) mice and dogs. The extension of rFVIIIFc half-life requires interaction of Fc with the neonatal Fc receptor (FcRn). In FcRn knockout mice, the extension of rFVIIIFc half-life is abrogated, and is restored in human FcRn transgenic mice. The Fc fusion has no impact on FVIII-specific activity. rFVIIIFc has comparable acute efficacy as rFVIII in treating tail clip injury in HemA mice, and fully corrects whole blood clotting time (WBCT) in HemA dogs immediately after dosing. Furthermore, consistent with prolonged half-life, rFVIIIFc shows 2-fold longer prophylactic efficacy in protecting HemA mice from tail vein transection bleeding induced 24-48 hours after dosing. In HemA dogs, rFVIIIFc also sustains partial correction of WBCT 1.5- to 2-fold longer than rFVIII. rFVIIIFc was well tolerated in both species. Thus, the rescue of FVIII by Fc fusion to provide prolonged protection presents a novel pathway for FVIII catabolism, and warrants further investigation. PMID:22246033

Age-hardening susceptibility of high-Cr ODS ferritic steels and SUS430 ferritic steel

Energy Technology Data Exchange (ETDEWEB)

Chen, Dongsheng, E-mail: chen.dongsheng85@gmail.com [Graduate School of Energy Science, Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan); Kimura, Akihiko; Han, Wentuo; Je, Hwanil [Institute of Advanced Energy, Kyoto University, Gokasho, Uji, Kyoto 611-0011 (Japan)

2015-10-15

Highlights: • The role of oxide particles in α/α′ phase decomposition behavior; microstructure of phase decomposition observed by TEM. • The characteristics of ductility loss caused by age-hardening. • Correlation of phase decomposition and age-hardening explained by dispersion strengthened models. • Age-hardening susceptibility of ODS steels and SUS430 steel. - Abstract: The effect of aging on high-Cr ferritic steels was investigated with focusing on the role of oxide particles in α/α′ phase decomposition behavior. 12Cr-oxide dispersion strengthened (ODS) steel, 15Cr-ODS steel and commercial SUS430 steel were isothermally aged at 475 °C for up to 10,000 h. Thermal aging caused a larger hardening in SUS430 than 15Cr-ODS, while 12Cr-ODS showed almost no hardening. A characteristic of the ODS steels is that the hardening was not accompanied by the significant loss of ductility that was observed in SUS430 steel. After aging for 2000 h, SUS430 steel shows a larger ductile–brittle transition temperature (DBTT) shift than 15Cr-ODS steel, which suggests that the age-hardening susceptibility is lower in 15Cr-ODS steel than in conventional SUS430 steel. Thermal aging leaded to a large number of Cr-rich α′ precipitates, which were confirmed by transmission electron microscopy (TEM). Correlation of age-hardening and phase decomposition was interpreted by Orowan type strengthening model. Results indicate that oxide particles cannot only suppress ductility loss, but also may influence α/α′ phase decomposition kinetics.

El perfil del consumidor de hostel en Brasil y sus motivaciones

OpenAIRE

Mané, Alexandra; Ferreira, Lissa

2017-01-01

El creciente número de hostels en Brasil ha atraído cada vez más brasileños que buscan este tipo de establecimiento para hospedarse. No obstante, vale destacar que deben realizarse más estudios que aborden la importancia de los hostels y sus consumidores en el mercado de turismo. Podrán contribuir al conocimiento teórico y práctico posibilitando un mejor entendimiento sobre este segmento. El objetivo de este artículo es identificar y describir el perfil del consumidor de hostel, sus motivacio...

EK(b)P Keskkomitee VIII pleenumi stenogramm / tõlk. Mart Arold, tõlk. Jaan Isotamm

Index Scriptorium Estoniae

1999-01-01

EK(b)P Keskkomitee VIII pleenum, 21.-23. märts 1950. Sõnavõtud: N. Karotamm, P. Ponomarenko, I. Käbin, V. Kuusik, A. Jaanus, V. Hiznjakov, E. Ristimägi, I. Suija, H. Ajo, A. Meri, G. Abels, M. Assin, G. Latõshov, Rumjantsev, Müürisepp. Kommenteerinud Viktor Niitsoo. Algus: Akadeemia (1998) nr. 12, lk. 2655-2683 ; Järg nr.2;3;4;5;6;7;8;9;10 lk.415-446;639-670;863-894;1087-1118;1310-1342;1534-1566;1759-1790;2017-2048;2220-2256

NETWORKS OF HEALTH CARE: A CHALLENGE TO SUS MANAGEMENT

Directory of Open Access Journals (Sweden)

Camila Dubow

2013-09-01

Full Text Available The article proposes a critical reflection, based on national law, scholarly, scientific, on the current development of Networks of Health Care, as a strategy for strengthening the Single Health System (SUS. Are weighted inefficiency of traditional ways of organizing care and management, the challenge of Network Health Care for comprehensive care and management mechanisms used in this process. The work provides subsidies for the care practices and health management are reflected, pointing strategies that result in disruptions of paradigms through a refocusing of attention in existing models. For networks of health care can be consolidated, is fundamental to political sensitivity of health managers with a commitment to build a new model of care, through the struggle to consolidate the SUS and the realization of the principles of universality, comprehensiveness and equity.

Low-dose factor VIII infusion in Chinese adult haemophilia A patients: pharmacokinetics evidence that daily infusion results in higher trough level than with every-other-day infusion with similar factor VIII consumption.

Science.gov (United States)

Hua, B; Lee, A; Fan, L; Li, K; Zhang, Y; Poon, M-C; Zhao, Y

2017-05-01

Pharmacokinetics (PK) modelling suggests improvement of trough levels are achieved by using more frequent infusion strategy. However, no clinical study data exists to confirm or quantify improvement in trough level, particularly for low-dose prophylaxis in patients with haemophilia A. To provide evidence that low dose daily (ED) prophylaxis can increase trough levels without increasing FVIII consumption compared to every-other-day (EOD) infusion. A cross-over study on 5 IU kg -1 FVIII daily vs. 10 IU kg -1 EOD infusions, each for 14 days was conducted at the PUMCH-HTC. On the ED schedule, trough (immediate prior to infusion), and peak FVIII:C levels (30 min after infusion) were measured on days 1-5; and trough levels alone on days 7, 9, 11 and 13. For the EOD schedule, troughs, peaks and 4-h postinfusion were measured on day 1; troughs and peaks on days 3, 5, and 7; troughs alone on days 9, 11 and 13 and 24-h postinfusion on days 2, 4 and 6. FVIII inhibitors were assessed on days 0 and 14 during both infusion schedules. Six patients were enrolled. PK evidence showed that daily prophylaxis achieved higher (~2 times) steady-state FVIII trough levels compared to EOD with the same total factor consumption. The daily prophylaxis had good acceptability among patients and reduced chronic pain in the joints in some patients. Our PK study shows low-dose factor VIII daily infusion results in higher trough level than with EOD infusion with similar factor VIII consumption in Chinese adult haemophilia A patients. © 2017 John Wiley & Sons Ltd.

Development of nanostructured SUS316L-2%TiC with superior tensile properties

Science.gov (United States)

Sakamoto, T.; Kurishita, H.; Matsuo, S.; Arakawa, H.; Takahashi, S.; Tsuchida, M.; Kobayashi, S.; Nakai, K.; Terasawa, M.; Yamasaki, T.; Kawai, M.

2015-11-01

Structural materials used in radiation environments require radiation tolerance and sufficient mechanical properties in the controlled state. In order to offer SUS316L austenitic stainless steel with the assumed requirements, nanostructured SUS316L with TiC addition of 2% (SUS316L-2TiC) that is capable of exhibiting enhanced tensile ductility and flow strength sufficient for structural applications was fabricated by advanced powder metallurgical methods. The methods include MA (Mechanical Alloying), HIP (Hot Isostatic Pressing), GSMM (Grain boundary Sliding Microstructural Modification) for ductility enhancement, cold rolling at temperatures below Md (the temperature where the martensite phase occurs by plastic deformation) for phase transformation from austenite to martensite and heat treatment for reverse transformation from martensite to austenite. It is shown that the developed SUS316L-2TiC exhibits ultrafine grains with sizes of 90-270 nm, accompanied by TiC precipitates with 20-50 nm in grain interior and 70-110 nm at grain boundaries, yield strengths of 1850 to 900 MPa, tensile strengths of 1920 to 1100 MPa and uniform elongations of 0.6-21%, respectively, depending on the heat treatment temperature after rolling at -196 °C.

Recurrent myocardial infarctions in a young football player secondary to thrombophilia, associated with elevated factor VIII activity

Directory of Open Access Journals (Sweden)

Vacek TP

2014-10-01

Full Text Available Thomas P Vacek, Shipeng Yu, Shahnaz Rehman, Blair P Grubb, Daniel Kosinski, Cherian Verghese, Ehab A Eltahawy, Shafiq Qaiser Department of Medicine, University of Toledo Medical Center, Toledo, OH, USAAbstract: Myocardial infarction (MI due to coronary atherosclerosis in young adults is uncommon; rare causes such as cocaine abuse, arterial dissection, and thromboembolism should be considered. A 21-year-old football player, and otherwise healthy African American man, developed chest pain during exercise while bench-pressing 400 lbs. Acute MI was diagnosed based on physical examination, electrocardiography findings, and elevated cardiac enzymes. Coronary arteriography showed a thrombus occluding the proximal left anterior descending artery (LAD. Aggressive antiplatelet therapy with aspirin, clopidogrel, and eptifibatide was pursued, in addition to standard post-MI care. This led to the successful resolution of symptoms and dissolution of the thrombus, demonstrated by repeat coronary arteriography. Five months later, he presented with similar symptoms during exercise after lifting heavy weights, and was found to have another acute MI. Coronary arteriography again showed a thrombus occluding the LAD. No evidence of coronary artery dissection or vasospasm was found. Only mild atherosclerotic plaque burden was observed on both occasions by intravascular ultrasound. A bare metal stent was placed at the site as it was thought this site had acted as a nidus for small plaque rupture and thrombus formation. Elevated serum factor VIII activity at 205% (reference range 60%–140% was found, a rare cause of hypercoagulability. Further workup revealed a patent foramen ovale during a Valsalva maneuver by transesophageal echocardiography. Both events occurred during weight lifting, which can transiently increase right heart pressure in a similar way to the Valsalva maneuver. In light of all the findings, we concluded that an exercise-related increase in factor

Potential role of a new PEGylated recombinant factor VIII for hemophilia A

Directory of Open Access Journals (Sweden)

Wynn TT

2016-06-01

Full Text Available Tung Thanh Wynn,1 Burak Gumuscu,2,3 1Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Florida, Gainesville, FL, 2Pediatric Hematology-Oncology, Bon Secours Health System, St. Mary’s Hospital, Richmond, VA, 3Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Virginia, Charlottesville, VA, USA Abstract: Hemophilia A, a deficiency in the activity of coagulation factor (F VIII, is an X-linked bleeding disorder with an approximate incidence of one in 5,000 male infants. Bleeding-related complications often result in greater severity of disease, poor quality of life, surgical interventions for severe joint destruction, and shortened life span. With the availability of plasma-derived and recombinant FVIII products, the benefits of primary prophylaxis were demonstrated and is now the standard of care for patients with severe factor deficiencies. Current hemophilia research is focusing on the creation of new factor replacement therapies with longer half-lives; accessing alternative mechanisms to achieve desired hemostasis and enhance bypassing ­activity; and limiting the immunogenicity of the protein. PEGylation involves the covalent attachment of polyethylene glycol (PEG to a protein, peptide, or a small molecule drug. PEG effectively increases the molecular weight and size of the protein by creating a hydrophilic cloud around the molecule. This molecular change may reduce susceptibility of the molecule to proteolytic activity and degradation. It is also believed that PEGylation changes the surface charge of the protein that ultimately interferes with some receptor-mediated clearance processes. The half-life of PEGylated factor is more prolonged when compared to non-PEGylated full-length recombinant FVIII. The dawn of a new era in the care of hemophilia patients is upon us with the release of recombinant FVIII products with extended half-lives, and products with even more extended half

Una frontera casi invisible: los territorios al norte del Sistema Central en la Alta Edad Media (siglos VIII-XI

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Iñaki MARTÍN VISO

2009-12-01

Full Text Available RESUMEN: Los territorios al norte del Sistema Central no estuvieron sujetos a un dominio por parte de una autoridad centralizada entre los siglos VIII a XI. Los instrumentos del poder central, en especial la tributación y la organización episcopal, se descompusieron tras el siglo VIII y asumieron un papel determinante las estructuras de poder local, las cuales deben ser el principal objeto de estudio. A partir de su análisis, se descubre un espacio fronterizo abierto, con un dominio político informal, que es invisible para los poderes centrales. Palabras clave: Poderes Locales. Sitios de Altura. Necrópolis. Frontera. Tributación. Mozárabes.ABSTRACT: The territories at the North of the Iberian Central System were not ruled by any central authority between eighth and eleventh centuries. The main tools of the central power, especially the tribute and the episcopal organization, were broken down after the 8th century and the structures of local power, which must be studied particularly, got a very influential role. The analysis discover an opened frontier area, with an informal political control, that is invisible from the perspective of the central power

Competencias parentales en Educación Sexual

OpenAIRE

Melo, María José; Zicavo, Nelson

2012-01-01

Esta investigación describe las competencias que madres y padres están utilizando en la educación sexual y prevención del abuso sexual de sus hijos en etapa escolar (en la VIII Región, Chile); considerando la prevención del abuso sexual como área relevante en una educación sexual integral. Desde la teoría sistémica de la sexualidad y un enfoque de género (con un diseño cualitativo de estudio de casos), padres y madres, apoderados, de una escuela municipalizada relataron sus experiencias. Cons...

Endothelial cell markers in vascular neoplasms: an immunohistochemical study comparing factor VIII-related antigen, blood group specific antigens, 6-keto-PGF1 alpha, and Ulex europaeus 1 lectin.

Science.gov (United States)

Little, D; Said, J W; Siegel, R J; Fealy, M; Fishbein, M C

1986-06-01

Markers for endothelial cells including Ulex europaeus 1 lectin, blood group A, B, and H, and the prostaglandin metabolite 6-keto-PGF1 alpha were evaluated in paraffin secretions from formalin-fixed benign and malignant vascular neoplasms using a variety of immunohistochemical techniques, and results compared with staining for factor VIII-related antigen. Staining for Ulex appeared more sensitive than factor VIII-related antigen in identifying poorly differentiated neoplasms including haemangiosarcomas and spindle cell proliferations in Kaposi's sarcoma. Staining for blood group related antigens correlated with blood group in all cases. Ulex europaeus 1 lectin was the only marker for endothelial cells in lymphangiomas.

Oral manifestations, dental management, and a rare homozygous mutation of the PRDM12 gene in a boy with hereditary sensory and autonomic neuropathy type VIII: a case report and review of the literature.

Science.gov (United States)

Elhennawy, Karim; Reda, Seif; Finke, Christian; Graul-Neumann, Luitgard; Jost-Brinkmann, Paul-Georg; Bartzela, Theodosia

2017-08-15

Hereditary sensory and autonomic neuropathy type VIII is a rare autosomal recessive inherited disorder. Chen et al. recently identified the causative gene and characterized biallelic mutations in the PR domain-containing protein 12 gene, which plays a role in the development of pain-sensing nerve cells. Our patient's family was included in Chen and colleagues' study. We performed a literature review of the PubMed library (January 1985 to December 2016) on hereditary sensory and autonomic neuropathy type I to VIII genetic disorders and their orofacial manifestations. This case report is the first to describe the oral manifestations, and their treatment, of the recently discovered hereditary sensory and autonomic neuropathy type VIII in the medical and dental literature. We report on the oral manifestations and dental management of an 8-month-old white boy with hereditary sensory and autonomic neuropathy-VIII over a period of 16 years. Our patient was homozygous for a mutation of PR domain-containing protein 12 gene and was characterized by insensitivity to pain and thermal stimuli, self-mutilation behavior, reduced sweat and tear production, absence of corneal reflexes, and multiple skin and bone infections. Oral manifestations included premature loss of teeth, associated with dental traumata and self-mutilation, severe soft tissue injuries, dental caries and submucosal abscesses, hypomineralization of primary teeth, and mandibular osteomyelitis. The lack of scientific knowledge on hereditary sensory and autonomic neuropathy due to the rarity of the disease often results in a delay in diagnosis, which is of substantial importance for the prevention of many complications and symptoms. Interdisciplinary work of specialized medical and dental teams and development of a standardized treatment protocols are essential for the management of the disease. There are many knowledge gaps concerning the management of patients with hereditary sensory and autonomic neuropathy-VIII

Retsensioon : Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare. Peatoimetaja Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. 326 lk. / Mart Nutt

Index Scriptorium Estoniae

Nutt, Mart, 1962-

2004-01-01

Arvustus: Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare / peatoim. Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. - Lisatud: Ott Heinapuu tutvustav sõnum retsenseeritud väljaande kohta lk. 193. - Vt. ka: http://www.riigikogu.ee/rito/index.php?id=11357

La educación secundaria en Perú y sus profesores: cambios y continuidades

Directory of Open Access Journals (Sweden)

Jerson Chuquilin Cubas

2011-01-01

Full Text Available Desde el momento en el que se constituyó el nuevo Estado peruano independiente del poder político español, el poder estatal se encargó de fundar y normar la organización y funcionamiento de las instituciones que conforman lo que hoy se conoce como sistema educativo. Dentro de este proceso, la educación secundaria ha experimentado desarrollos peculiares que la diferencian de los otros niveles educativos en lo que se refiere a las instituciones en las que se imparte, sus propósitos, la formación de sus profesores, las posiciones instituidas y el sentido asignado al quehacer docente y directivo. Así, la educación secundaria nació ligada a la educación superior universitaria y al servicio de una minoría privilegiada. Sus profesores, de una élite privilegiada al servicio del proyecto homogeneizador del Estado, han transitado hacia una situación de deterioro de sus condiciones de vida y desvalorización de su trabajo.

José Manuel Esteve : sus contribuciones al estudio de la profesión docente

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Julio Vera

2013-07-01

Full Text Available Este artículo es un análisis de las contribuciones del profesor Esteve al estudio de la profesión docente. Para ello se hace un repaso a sus rasgos de personalidad, a los hitos más relevantes de su vida profesional y a algunas de sus publicaciones desde sus comienzos como profesor universitario en 1973 hasta su fallecimiento en el año 2010.This article analyzes the contributions of Professor Esteve around the teaching profession. His personality traits, the highlights of his career and some of his publications from his beginnings as a university professor in 1973 until his death in 2010 are the core of this study.

Structure of BT-3984, a member of the SusD/RagB family of nutrient-binding molecules

International Nuclear Information System (INIS)

Bakolitsa, Constantina; Xu, Qingping; Rife, Christopher L.; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Carlton, Dennis; Chen, Connie; Chiu, Hsiu-Ju; Clayton, Thomas; Das, Debanu; Deller, Marc C.; Duan, Lian; Ellrott, Kyle; Farr, Carol L.; Feuerhelm, Julie; Grant, Joanna C.; Grzechnik, Anna; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kozbial, Piotr; Krishna, S. Sri; Kumar, Abhinav; Lam, Winnie W.; Marciano, David; McMullan, Daniel; Miller, Mitchell D.; Morse, Andrew T.; Nigoghossian, Edward; Nopakun, Amanda; Okach, Linda; Puckett, Christina; Reyes, Ron; Tien, Henry J.; Trame, Christine B.; Bedem, Henry van den; Weekes, Dana; Hodgson, Keith O.; Wooley, John; Elsliger, Marc-André; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

2010-01-01

The crystal structure of BT-3984, a SusD-family protein, reveals a TPR N-terminal region providing support for a loop-rich C-terminal subdomain and suggests possible interfaces involved in sus complex formation. The crystal structure of the Bacteroides thetaiotaomicron protein BT-3984 was determined to a resolution of 1.7 Å and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm for glycan utilization in dominant members of the human gut microbiota. Structural analysis of BT-3984 revealed an N-terminal region containing several tetratricopeptide repeats (TPRs), while the signature C-terminal region is less structured and contains extensive loop regions. Sequence and structure analysis of BT-3984 suggests the presence of binding interfaces for other proteins from the polysaccharide-utilization complex

La Eutonía-Sus Principios

OpenAIRE

Rovella, Adriana

2008-01-01

El presente trabajo pretende dar cuenta de la Eutonía como práctica corporal dando cuenta de sus objetivos y principios La Eutonía fue creada por Gerda Alexander.El término, del griego, Eu: bueno, óptimo-Tonus: tensión; expresa la idea de una tonicidad armoniosamente equilibrada en adaptación constante al estado o actividad del momento. Es una disciplina basada en la experiencia del propio cuerpo, que conduce a la persona hacia una toma de conciencia de si misma y propone un aprendizaje para ...

Underground Test Area Subproject Phase I Data Analysis Task. Volume VIII - Risk Assessment Documentation Package

Energy Technology Data Exchange (ETDEWEB)

None

1996-12-01

Volume VIII of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the risk assessment documentation. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

Proceso constructivo de redes de distribución de gas natural, residencial y comercial en Lima y Callao

OpenAIRE

Medina Yupanqui, Jorge Nander; Medina Yupanqui, Jorge Nander; Medina Yupanqui, Jorge Nander

2015-01-01

Las redes de gas natural están presentes en diferentes distritos de Lima y Callao, y son de tres tipos diferenciados por la presión que soportan; red de alta presión (red principal que cruza Lima), la red de media presión (abastece generadoras eléctricas, industrias y grifos de GNV), y la red de baja presión (abastece viviendas y comercios). La red de alta presión que cruza todo Lima es para el consumo actual, garantiza la conducción para el abastecimiento de gas a Lima y Callao. Las re...

Biochemical and Molecular Characterization of RcSUS1, a Cytosolic Sucrose Synthase Phosphorylated in Vivo at Serine 11 in Developing Castor Oil Seeds*

Science.gov (United States)

Fedosejevs, Eric T.; Ying, Sheng; Park, Joonho; Anderson, Erin M.; Mullen, Robert T.; She, Yi-Min; Plaxton, William C.

2014-01-01

Sucrose synthase (SUS) catalyzes the UDP-dependent cleavage of sucrose into UDP-glucose and fructose and has become an important target for improving seed crops via metabolic engineering. A UDP-specific SUS homotetramer composed of 93-kDa subunits was purified to homogeneity from the triacylglyceride-rich endosperm of developing castor oil seeds (COS) and identified as RcSUS1 by mass spectrometry. RcSUS1 transcripts peaked during early development, whereas levels of SUS activity and immunoreactive 93-kDa SUS polypeptides maximized during mid-development, becoming undetectable in fully mature COS. The cytosolic location of the enzyme was established following transient expression of RcSUS1-enhanced YFP in tobacco suspension cells and fluorescence microscopy. Immunological studies using anti-phosphosite-specific antibodies revealed dynamic and high stoichiometric in vivo phosphorylation of RcSUS1 at its conserved Ser-11 residue during COS development. Incorporation of 32Pi from [γ-32P]ATP into a RcSUS1 peptide substrate, alongside a phosphosite-specific ELISA assay, established the presence of calcium-dependent RcSUS1 (Ser-11) kinase activity. Approximately 10% of RcSUS1 was associated with COS microsomal membranes and was hypophosphorylated relative to the remainder of RcSUS1 that partitioned into the soluble, cytosolic fraction. Elimination of sucrose supply caused by excision of intact pods of developing COS abolished RcSUS1 transcription while triggering the progressive dephosphorylation of RcSUS1 in planta. This did not influence the proportion of RcSUS1 associated with microsomal membranes but instead correlated with a subsequent marked decline in SUS activity and immunoreactive RcSUS1 polypeptides. Phosphorylation at Ser-11 appears to protect RcSUS1 from proteolysis, rather than influence its kinetic properties or partitioning between the soluble cytosol and microsomal membranes. PMID:25313400

Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia

DEFF Research Database (Denmark)

Larsen, Malte Selch; Juul, Rasmus Vestergaard; Groth, Andreas Velsing

2018-01-01

activated factor VII (rFVIIa) and recombinant factor VIII (rFVIII) in several experimental animal models using population PK modelling, and apply a simulation-based approach to evaluate how well the developed animal population PK models predict human PK. PK models were developed for rFVIIa and r...

Microstructures and Mechanical Properties of Austempering SUS440 Steel Thin Plates

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Cheng-Yi Chen

2016-02-01

Full Text Available SUS440 is a high-carbon stainless steel, and its martensite matrix has high heat resistance, high corrosion resistance, and high pressure resistance. It has been widely used in mechanical parts and critical materials. However, the SUS440 martempered matrix has reliability problems in thin plate applications and thus research uses different austempering heat treatments (tempering temperature: 200 °C–400 °C to obtain a matrix containing bainite, retained austenite, martensite, and the M7C3 phase to investigate the relationships between the resulting microstructure and tensile mechanical properties. Experimental data showed that the austempering conditions of the specimen affected the volume fraction of phases and distribution of carbides. After austenitizing heat treatment (1080 °C for 30 min, the austempering of the SUS440 thin plates was carried out at a salt-bath temperature 300 °C for 120 min and water quenching was then used to obtain the bainite matrix with fine carbides, with the resulting material having a higher tensile fracture strength and average hardness (HRA 76 makes it suitable for use as a high-strength thin plate for industrial applications.

Hijos adultos mayores al cuidado de sus padres, un fenómeno reciente

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P. Beatriz Zegers, PS.

2012-01-01

Full Text Available Es un hecho inédito en la historia de la humanidad que hijos que han llegado a la ancianidad cuiden de sus padres. Se mostrarán las particulares vicisitudes y desafíos que se plantean en el seno de la familia extensa cuando se trata de hijos adultos mayores quienes asumen la tarea de cuidar a sus padres, ya que éstas difieren de aquellas que se formulan cuando los hijos se encuentran en la adultez media. Si bien muchas familias se adaptan sin grandes sobresaltos a esta transición biográfica, otras se enfrentan a auténticas crisis. Distinguirlas puede ayudar a los profesionales de salud a manejar de mejor modo a sus pacientes y también ayudar a quienes se encuentran abocados a esta tarea.

A dimensão política do processo de formação de pessoal auxiliar: a enfermagem rumo ao SUS La dimensión política del proceso de formación del personal auxiliar: la enfermeria rumbo al SUS (Sistema Único de Salud The political dimension of auxiliary personnel education: nursing and the Unified Health System (SUS

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Alva Helena de Almeida

2002-10-01

Full Text Available A mudança de administração no município de São Paulo em 1989 inovou a gestão dos serviços de saúde, objetivando a implementação do Sistema Único de Saúde (SUS e tendo como uma estratégia fundamental a qualificação dos trabalhadores. Este artigo objetiva analisar a incorporação dos princípios do SUS aos cursos de formação de auxiliares de enfermagem. Partindo dos conceitos que nutriram a Reforma Sanitária e a construção dos princípios do SUS, o caminho metodológico empreendido utilizou entrevistas com os coordenadores do programa. A análise permitiu reconhecer que a política e as práticas da gestão municipal estavam comprometidas com o SUS; priorizou-se a qualificação dos trabalhadores da saúde que não haviam tido oportunidade; adotou-se uma pedagogia voltada à "transformação" dos agentes; os coordenadores motivaram-se a desenvolver a qualificação, reconhecendo o processo como uma ferramenta de implementação do SUS; os coordenadores do nível regional apreenderam a dimensão técnica do processo, isolada da política.El cambio de administración en el Municipio de São Paulo, en 1989, innovó la gestión de los servicios de salud, buscando la implementación del Sistema Único de Salud, (SUS teniendo como estrategia fundamental la cualificación de los trabajadores. Este artículo analizó la incorporación de los principios del SUS en la formación de auxiliares de enfermería. Se realizaron entrevistas con los coordinadores del programa y su análisis permitió reconocer que: las políticas y prácticas de la gestión municipal estaban comprometidas con el SUS; se priorizó la cualificación de los trabajadores de la salud que no habían tenido oportunidad; fue adoptada una pedagogía orientada hacia la "transformación" de los agentes; los coordinadores se motivaron para desarrollar esa cualificación, reconociendo el proceso como una herramienta para implementar el SUS; los coordinadores regionales

A novel link between Sus1 and the cytoplasmic mRNA decay machinery suggests a broad role in mRNA metabolism

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Llopis Ana

2010-03-01

Full Text Available Abstract Background Gene expression is achieved by the coordinated action of multiple factors to ensure a perfect synchrony from chromatin epigenetic regulation through to mRNA export. Sus1 is a conserved mRNA export/transcription factor and is a key player in coupling transcription initiation, elongation and mRNA export. In the nucleus, Sus1 is associated to the transcriptional co-activator SAGA and to the NPC associated complex termed TREX2/THSC. Through these associations, Sus1 mediates the nuclear dynamics of different gene loci and facilitate the export of the new transcripts. Results In this study, we have investigated whether the yeast Sus1 protein is linked to factors involved in mRNA degradation pathways. We provide evidence for genetic interactions between SUS1 and genes coding for components of P-bodies such as PAT1, LSM1, LSM6 and DHH1. We demonstrate that SUS1 deletion is synthetic lethal with 5'→3' decay machinery components LSM1 and PAT1 and has a strong genetic interaction with LSM6 and DHH1. Interestingly, Sus1 overexpression led to an accumulation of Sus1 in cytoplasmic granules, which can co-localise with components of P-bodies and stress granules. In addition, we have identified novel physical interactions between Sus1 and factors associated to P-bodies/stress granules. Finally, absence of LSM1 and PAT1 slightly promotes the Sus1-TREX2 association. Conclusions In this study, we found genetic and biochemical association between Sus1 and components responsible for cytoplasmic mRNA metabolism. Moreover, Sus1 accumulates in discrete cytoplasmic granules, which partially co-localise with P-bodies and stress granules under specific conditions. These interactions suggest a role for Sus1 in gene expression during cytoplasmic mRNA metabolism in addition to its nuclear function.

Effect of pH on the corrosion behaviour of SUS321 in the ammonia aqueous solution

International Nuclear Information System (INIS)

Park, Sang Yoon; Jeong, Y. H.; Baek, J. H.; Choi, B. K.; Lee, M. H.; Choi, B. S.; Yoon, J. H.; Lee, D. J.

2003-02-01

The corrosion characteristics of SUS321 for pressure vessel of SMART in pure water, ammonia aqueous solutions of pH 8.5 ∼ 11.5 at 300 .deg. C were evaluated by using static autoclaves. SUS321 specimen in the high temperature ammonia aqueous solution has weight gain or loss by the 4 reactions. And it depends on the refreshing period of the aqueous solution. So additional experiments by recirculating loop system were required to evaluate the corrosion behaviour of SUS321 in the ammonia aqueous solution

Measurements of the ground-state ionization energy and wavelengths for the 1snp 1P1*-1s21S0 (n=4-9) lines of Mg XI and F VIII

International Nuclear Information System (INIS)

Pal'chikov, V.G.; Ya Faenov, A.; Yu Skobelev, I.

2002-01-01

The wavelengths of the 1snp 1 P 1 0 -1s 2 1 S 0 transitions in the He-like Mg XI (n = 4-9) and F VIII (n=4-8) have been measured in laser-produced plasmas. The accuracy of the present measurements (0.4-1.6 mA) is a large improvement over previous results. The Rydberg series is used to determine the ground-state ionization energy of F VIII and Mg XI: E i on (F VIII) 953.96±0.11 eV, E i on (Mg XI)=1761.88±0.15 eV. These experimental results are compared with theoretical data calculated by the 1/Z-expansion method and the HFR and MCDF approaches. Fairly good agreement between theory and experiment is observed with a precision up to 5x10 -5 . Radiative corrections to the 1s 2 1 S 0 state are analysed and compared with experiments. It is found that QED corrections to the ground-state ionization energy are significant at the present level of experimental accuracy. (author)

Deliverable D4.5. Failure Mode and Effect Analysis for 100% waste concrete. SUS-CON

NARCIS (Netherlands)

Visser, J.H.M.

2014-01-01

On January 1st 2012, the European project SUS-CON has been started: “SUStainable, innovative and energy efficient CONcrete, based on the integration of all waste materials” (grant agreement no: 285463). The SUS-CON project aims at developing new technology routes to integrate waste materials in the

Weldability of dissimilar joint between F82H and SUS316L under fiber laser welding

Energy Technology Data Exchange (ETDEWEB)

Serizawa, Hisashi [Joining and Welding Research Institute, Osaka University, 11-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Mori, Daiki; Shirai, Yuma; Ogiwara, Hiroyuki; Mori, Hiroaki [Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan)

2013-10-15

Highlights: • The microstructure of F82H/SUS316L dissimilar joint can be divided into four regions. • In the case without beam position shift, hardness of WM cannot be reduced by PWHT. • The fiber laser welding would be applicable for constructing the dissimilar joint. -- Abstract: As one of the high beam quality heat sources, 4 kW fiber laser was applied for joining between reduced activation ferritic/martensitic steel, F82H and SUS316L austenitic stainless steel, and the microstructural analyses and Vickers hardness measurements were carried out before and after post-weld heat treatment (PWHT). The microstructure of joint can be divided into four regions which are base metal of F82H, heat affected zone (HAZ) in F82H, weld metal (WM) and base metal of SUS316L. Also, it is revealed that the high-power fiber laser can be employed for constructing butt joint between F82H and SUS316L by applying PWHT and shifting the laser beam position to SUS316L, where the distance between the contact face and beam should be set as a range from radius to diameter of laser beam.

Weldability of dissimilar joint between F82H and SUS316L under fiber laser welding

International Nuclear Information System (INIS)

Serizawa, Hisashi; Mori, Daiki; Shirai, Yuma; Ogiwara, Hiroyuki; Mori, Hiroaki

2013-01-01

Highlights: • The microstructure of F82H/SUS316L dissimilar joint can be divided into four regions. • In the case without beam position shift, hardness of WM cannot be reduced by PWHT. • The fiber laser welding would be applicable for constructing the dissimilar joint. -- Abstract: As one of the high beam quality heat sources, 4 kW fiber laser was applied for joining between reduced activation ferritic/martensitic steel, F82H and SUS316L austenitic stainless steel, and the microstructural analyses and Vickers hardness measurements were carried out before and after post-weld heat treatment (PWHT). The microstructure of joint can be divided into four regions which are base metal of F82H, heat affected zone (HAZ) in F82H, weld metal (WM) and base metal of SUS316L. Also, it is revealed that the high-power fiber laser can be employed for constructing butt joint between F82H and SUS316L by applying PWHT and shifting the laser beam position to SUS316L, where the distance between the contact face and beam should be set as a range from radius to diameter of laser beam

Jogo (indica-sus: estratégia lúdica na aprendizagem sobre o sistema único de saude

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Maria Raquel Gomes Maia Pires

2013-01-01

Full Text Available Es cuestionable que tecnología lúdico-educativa en el aprendizaje acerca de SUS favorece la imaginación, relajación, espontaneidad y reflexión en la formación de los profesionales de la salud. Los objetivos fueram desarrollar el juego (INDICA-SUS centrado en diálogo sobre políticas de salud con los juguetones; analizar componentes de relajación, placer, aspectos formativos, emociones y tácticas del desarrollo del (INDICA-SUS; identificar las variables indicativas de lo lúdico en tecnologías educativas para la salud. Enfoque exploratorio, descriptivo, cuantitativo y cualitativo, estudio de caso. Las pruebas se realizaron con partidas testes de 180 participantes, cuestionarios, observación participante, análisis de contenido y prueba estadística de Pearson. Las variables indicativas de ludicidad de tecnologías de educación para la salud incluyen placer y tensión en el juego. El (INDICA-SUS integra carácter inventivo, imaginativo e de intercambio como potencial para la formación; contemplase aprendizaje múltiple y el enseño del SUS, a partir de él.

Jorge Santayana y sus vínculos humanos en Avila. Breve recopilación epistolar

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Pedro GARCÍA MARTÍN

2009-11-01

Full Text Available Es, hasta cierto punto, conocida la vinculación abulense de Santayana. Se sabe que aquí pasó su infancia a partir de los dos años; se conocen también, en etapas posteriores, sus frecuentes escapadas veraniegas para ver a su padre primero y a sus hermanas después, especialmente a su hermana Susana que aquí casó y proporcionó finalmente al filósofo una verdadera familia hasta el final de sus días. Poco se ha profundizado, sin embargo, sobre el alcance real de esta influyente vinculación y sobre la cualidad particular de este sustrato abulense.

MENINGKATKAN TANGGUNG JAWAB SOSIAL SISWA KELAS VIII MELALUI LAYANAN BIMBINGAN KELOMPOK

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Ummi Farikhatun Nisa

2012-12-01

Full Text Available The purpose of this research was to determine the efforts and success in improving students' social responsibility through group counseling services. Type of research used action research. Subjects were 12 students who had low social responsibility and being. Data collection technique used were psychological scales and observation. Data analysis techniques used are non-parametric statistics with the Wilcoxon test. Based on the calculations for the Wilcoxon test, a small amount of levels or Z value was 78.0. While Ztabel for n = 12 with an error level of 5% value is 14. So Z 78.0> 14.0 Ztabel or imply hypothesis accepted. These results demonstrate social responsibility of students prior to obtaining counseling services group at 51.93% (low. After following the guidance services at 81.51% (high. Conclusions from this research is a social responsibility to the students of class VIII SMP Putra Bangsa Bantarkawung increase after getting tutoring services group.

Development of nanostructured SUS316L-2%TiC with superior tensile properties

Energy Technology Data Exchange (ETDEWEB)

Sakamoto, T., E-mail: sakamoto.tatsuaki.mm@ehime-u.ac.jp [Department of Materials Science and Biotechnology, Ehime University, Matsuyama 790-8577 (Japan); Kurishita, H.; Matsuo, S.; Arakawa, H. [International Research Center for Nuclear Materials Science, IMR, Tohoku University, Oarai, Ibaraki 311-1313 (Japan); Takahashi, S.; Tsuchida, M. [Ehime University, Matsuyama 790-8577 (Japan); Kobayashi, S.; Nakai, K. [Department of Materials Science and Biotechnology, Ehime University, Matsuyama 790-8577 (Japan); Terasawa, M. [Laboratory of Advanced Science & Technology for Industry, University of Hyogo, 3-1-2 Koto, Kamigori-cho, Hyogo 678-1205 (Japan); Yamasaki, T. [Department of Materials Science & Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2201 (Japan); Kawai, M. [High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki-ken 305-0801 (Japan)

2015-11-15

Structural materials used in radiation environments require radiation tolerance and sufficient mechanical properties in the controlled state. In order to offer SUS316L austenitic stainless steel with the assumed requirements, nanostructured SUS316L with TiC addition of 2% (SUS316L-2TiC) that is capable of exhibiting enhanced tensile ductility and flow strength sufficient for structural applications was fabricated by advanced powder metallurgical methods. The methods include MA (Mechanical Alloying), HIP (Hot Isostatic Pressing), GSMM (Grain boundary Sliding Microstructural Modification) for ductility enhancement, cold rolling at temperatures below M{sub d} (the temperature where the martensite phase occurs by plastic deformation) for phase transformation from austenite to martensite and heat treatment for reverse transformation from martensite to austenite. It is shown that the developed SUS316L-2TiC exhibits ultrafine grains with sizes of 90–270 nm, accompanied by TiC precipitates with 20–50 nm in grain interior and 70–110 nm at grain boundaries, yield strengths of 1850 to 900 MPa, tensile strengths of 1920 to 1100 MPa and uniform elongations of 0.6–21%, respectively, depending on the heat treatment temperature after rolling at −196 °C. - Highlights: • Nanostructured SUS316L-2%TiC exhibiting sufficient tensile ductility and strength is developed. • The development requires an advanced powder metallurgical route. • The route includes MA, HIP, GSMM and thermo-mechanical treatments for phase transformation. • The austenite grain sizes are 90–270 nm and TiC precipitates 20–50 nm in grain interior. • The tensile strength are 1100–1920 MPa and uniform elongation 0.6–21%.

Development of nanostructured SUS316L-2%TiC with superior tensile properties

International Nuclear Information System (INIS)

Sakamoto, T.; Kurishita, H.; Matsuo, S.; Arakawa, H.; Takahashi, S.; Tsuchida, M.; Kobayashi, S.; Nakai, K.; Terasawa, M.; Yamasaki, T.; Kawai, M.

2015-01-01

Structural materials used in radiation environments require radiation tolerance and sufficient mechanical properties in the controlled state. In order to offer SUS316L austenitic stainless steel with the assumed requirements, nanostructured SUS316L with TiC addition of 2% (SUS316L-2TiC) that is capable of exhibiting enhanced tensile ductility and flow strength sufficient for structural applications was fabricated by advanced powder metallurgical methods. The methods include MA (Mechanical Alloying), HIP (Hot Isostatic Pressing), GSMM (Grain boundary Sliding Microstructural Modification) for ductility enhancement, cold rolling at temperatures below M_d (the temperature where the martensite phase occurs by plastic deformation) for phase transformation from austenite to martensite and heat treatment for reverse transformation from martensite to austenite. It is shown that the developed SUS316L-2TiC exhibits ultrafine grains with sizes of 90–270 nm, accompanied by TiC precipitates with 20–50 nm in grain interior and 70–110 nm at grain boundaries, yield strengths of 1850 to 900 MPa, tensile strengths of 1920 to 1100 MPa and uniform elongations of 0.6–21%, respectively, depending on the heat treatment temperature after rolling at −196 °C. - Highlights: • Nanostructured SUS316L-2%TiC exhibiting sufficient tensile ductility and strength is developed. • The development requires an advanced powder metallurgical route. • The route includes MA, HIP, GSMM and thermo-mechanical treatments for phase transformation. • The austenite grain sizes are 90–270 nm and TiC precipitates 20–50 nm in grain interior. • The tensile strength are 1100–1920 MPa and uniform elongation 0.6–21%.

Healthcare regions and their care networks: an organizational-systemic model for SUS.

Science.gov (United States)

Santos, Lenir

2017-04-01

This paper describes a comprehensive effort to develop studies regarding Brazil's Unified Healthcare System (SUS), as a result of the combination of public services in a network that follows a region-based rationale (tripartite organization). The SUS emerges from such an integration and should be organized as such. The intention is to demonstrate that this type of organization is essential, given that Brazil is organized as a Federation, and all three governmental levels are, in a broad sense, equally responsible for healthcare. Healthcare services and actions are a complex set of activities that are interconnected on behalf of citizen health, which is a global concept that cannot be split up. Services must follow this rationale and be organized as such. Thus, healthcare services must be systematically organized to serve everyone equally, regardless of where a citizen lives. This systemic organization requires permanent interaction between federative units to discuss and operationalize reference services, funding and other technical and administrative aspects. These are the essential elements that make the SUS so complex and demand it be organized regionally, as a network of healthcare services.

Assessing patients' and caregivers' perspectives on stability of factor VIII products for haemophilia A

DEFF Research Database (Denmark)

DiBenedetti, D B; Coles, T M; Sharma, T

2014-01-01

Haemophilia A is a rare inherited bleeding disorder characterized by an inability of the blood to clot normally. Patients can experience spontaneous or trauma-induced joint and soft tissue bleeding and must keep coagulation factor VIII (FVIII) accessible at all times; thus, FVIII product storage...... challenges with storing FVIII products, especially storage away from home. More than half preferred storing FVIII products at room temperature vs. in the refrigerator for long periods of time. FVIII product accessibility, usage and storage affect disease management. Results support the need for more...... convenient and accessible FVIII products for patients in daily life and while travelling. In addition, the use of social media has potential value in recruiting this population....

Mitochondrial genome of Taiwan pig ( Sus Scrofa ) | Chen | African ...

African Journals Online (AJOL)

The purpose of this study is to investigate the complete nucleotide sequence of the mitochondrial genome of the Taiwan Lanyu pig (Sus scrofa) and its phylogenetic relationships with other pig breeds. Thirty-four forward and reverse primers were designed. Sequencing was performed in both directions. The results showed ...

Hubungan Self-esteem dan Penggunaan Media Sosial Instagram dengan Perilaku Narsisme di Kalangan Siswa Kelas VIII Smpk Penabur Bintaro Jaya

OpenAIRE

Wibowo, Yonatan; Silaen, Sondang Maria J

2018-01-01

Tujuan dari penelitian ini adalah untuk mengetahui ada tidaknya hubungan self-esteem dan penggunaanmedia sosial Instagram dengan perilaku narsisme di kalangan siswa kelas VIII SMPK Penabur Bintaro Jaya.Dalam penelitian ini terdapat tiga variabel, yaitu perilaku narsisme sebagai variabel terikat serta self-esteem danpenggunaan media sosial Instagram sebagai variabel bebas. Sampel dalam penelitian ini adalah siswa kelasdelapan tahun pelajaran 2016/2017. Teknik pengambilan sampel dalam penelitia...

Il ruolo di El Escorial, V.III.6 e dei suoi discendenti nella tradizione manoscritta del Lucullus

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Corinna Senore

2017-05-01

Full Text Available L’articolo riguarda un gruppo di sette codici che tramanda il testo del Lucullus di Cicerone e che appartiene al ramo della tradizione discendente dal manoscritto Wien, Österreichische Nationalbibliothek 189. I sette manoscritti costituiscono uno stadio della tradizione caratterizzato dalla presenza di tre lacune testuali. Sulla base di alcuni elementi paleografici e della presenza di una glossa riportata a margine del testo di uno di essi, El Escorial, V.III.6 (Scor4, e inglobata all’interno del testo degli altri sei, è possibile individuare in Scor4 il capostipite di questo gruppo della tradizione. Lo studio si occupa inoltre di fare chiarezza sui rapporti che intercorrono tra i sei discendenti di Scor4. The article focuses on a group of seven codices which carry the text of Cicero’s Lucullus. This group belongs to the branch of the tradition descending from the manuscript Wien, Österreichische Nationalbibliothek 189. The seven manuscripts represent a step of the tradition marked by the presence of some textual lacunas. I start from some paleographic elements and from the presence of a gloss on text’s margin of one of them, El Escorial, V.III.6 (Scor4. The gloss has been then incorporated in the text of the other six manuscripts and I assume that Scor4 is the founder of this group of tradition. Furthermore, this article aims to clarify the relations between the six descendants of Scor4.

Propósitos de la comunicación entre empresas y sus seguidores en Facebook

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G Valerio Ureña

2015-02-01

Full Text Available Introducción: La investigación del comportamiento del consumidor en las redes sociales en línea está despertando un creciente interés entre la comunidad empresarial debido a las nuevas e inexploradas oportunidades y amenazas que trae consigo, incluyendo la vasta cantidad de datos generados día con día. El propósito de este estudio es explorar el uso de Facebook como fuente valiosa de información para identificar la naturaleza y el contenido de las conversaciones de las empresas de telecomunicaciones mexicanas y sus seguidores. Metodología: a través de una metodología cualitativa se analizaron 2,000 publicaciones (1000 realizadas por las empresas y 1,000 publicaciones realizadas por sus seguidores. Resultados y conclusiones: los resultados sugieren que las compañías de telecomunicaciones utilizan Facebook primordialmente para sus relaciones públicas, publicidad y promoción; mientras que sus usuarios las utilizan primordialmente para reportar incidentes y problemas, formular quejas y solucionar dudas.

Material test data of SUS304 welded joints

Energy Technology Data Exchange (ETDEWEB)

Asayama, Tai [Japan Nuclear Cycle Development Inst., Oarai, Ibaraki (Japan). Oarai Engineering Center; Kawakami, Tomohiro [Nuclear Energy System Incorporation, Tokyo (Japan)

1999-10-01

This report summarizes the material test data of SUS304 welded joints. Numbers of the data are as follows: Tensile tests 71 (Post-irradiation: 39, Others: 32), Creep tests 77 (Post-irradiation: 20, Others: 57), Fatigue tests 50 (Post-irradiation: 0), Creep-fatigue tests 14 (Post-irradiation: 0). This report consists of the printouts from 'the structural material data processing system'. (author)

Inmigrantes andinos en Madrid: Sus danzas y sus músicas tradicionales

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Lourdes Morales

2007-01-01

Full Text Available In our urban context we get in touch with people that have been forced to leave their countries under different circumstances in order to live in Spain. This article analyses their wish to maintain a group identity and how this identity is materialized by some individuals through traditional dance and music. The study is intended as a framework for subsequent educational investigations that relate that cultural reality with the situation in secondary schools where children of Latin American immigrants study.Nuestro entorno ciudadano inmediato nos pone en contacto diario con personas que por diferentes razones se han visto obligadas a dejar sus países de origen para instalarse en España. Este artículo analiza el deseo que surge en ellas de mantener una identidad de grupo, y cómo ésta se concreta en ciertos individuos mediante manifestaciones de danza y música popular tradicional. El estudio pretende servir de marco para ulteriores investigaciones educativas que vinculen esa realidad cultural con la situación de institutos de enseñanza secundaria en los que estudian hijos de inmigrantes latinoamericanos.

Love and/in psychoanalysis: a commentary on Lacan's reading of Plato's Symposium in Seminar VIII: Transference.

Science.gov (United States)

Fink, Bruce

2015-02-01

What is love and what part does it play in psychoanalysis? Where are the analyst and the analysand situated in relation to the roles defined as those of the "lover" and the "beloved"? Jacques Lacan explores these and other questions in his soon-to-be-published Seminar VIII: Transference by providing an extensive commentary on Plato's most famous dialogue on love, the Symposium. This paper outlines some of the major points about love that grow out of Lacan's reading of the dialogue and examines their relevance to the analytic setting. Can the analyst be characterized as a sort of modern-day Socrates?

Revisión del concepto de calidad del servicio y sus modelos de medición

OpenAIRE

Edison Jair Duque Oliva

2005-01-01

En este trabajo se revisan las diferentes conceptualizaciones sobre el servicio y los modelos más reconocidos para la evaluación de la percepción de la calidad del servicio aparecidos en los últimos años. Se ofrece una breve descripción de dichos modelos, sus características más significativas, sus objetivos y sus diferencias. Los estudios sobre la evolución histórica de la gestión, la calidad y el marketing de servicios, ya enfocados en la evaluación de la calidad del servicio, se agru...

Role of the mRNA export factor Sus1 in oxidative stress tolerance in Candida albicans.

Science.gov (United States)

Xiao, Chenpeng; Yu, Qilin; Zhang, Bing; Li, Jianrong; Zhang, Dan; Li, Mingchun

2018-02-05

In eukaryotes, the nuclear export of mRNAs is essential for gene expression. However, little is known about the role of mRNA nuclear export in the important fungal pathogen, Candida albicans. In this study, we identified C. albicans Sus1, a nucleus-localized protein that is required for mRNA export. Interestingly, the sus1Δ/Δ displayed hyper-sensitivity to extracellular oxidative stress, enhanced ROS accumulation and severe oxidative stress-related cell death. More strikingly, although the mutant exhibited normal activation of the expression of oxidative stress response (OSR) genes, it had attenuated activity of ROS scavenging system, which may be attributed to the defect in OSR mRNA export in this mutant. In addition, the virulence of the sus1Δ/Δ was seriously attenuated. Taken together, our findings provide evidence that the mRNA export factor Sus1 plays an important role in oxidative stress tolerance and pathogenesis. Copyright © 2018 Elsevier Inc. All rights reserved.

20 CFR 404.535 - How much will we withhold from your title VIII and title XVI benefits to recover a title II...

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How much will we withhold from your title... Officer § 404.535 How much will we withhold from your title VIII and title XVI benefits to recover a title II overpayment? (a) If past-due benefits are payable to you, we will withhold the lesser of the...

Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis

NARCIS (Netherlands)

Valentino, L. A.; Pipe, S. W.; Collins, P. W.; Blanchette, V. S.; Berntorp, E.; Fischer, K.; Ewenstein, B. M.; Oh, M.; Spotts, G.

2016-01-01

Introduction: We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been

The Funnel Geometry of Open Flux Tubes in the Low Solar Corona Constrained by O VI and Ne VIII Outflow

Science.gov (United States)

Byhring, Hanne S.; Esser, Ruth; Lie-Svendsen, Oystein

2008-01-01

Model calculations show that observed outflow velocities of order 7-10 km/s of C IV and O VI ions, and 15-20 km/s of Ne VIII ions, are not only consistent with models of the solar wind from coronas holes, but also place unique constraints on the degree of flow tube expansion as well as the location of the expansion in the transition region/lower corona.

Financiando o SUS: algumas questões para o debate Funding the Brazilian National Health Service (SUS: some issues for the debate

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Ruben Araujo de Mattos

2003-09-01

Full Text Available Este debate discute questões relacionadas ao financiamento do Sistema Único de Saúde (SUS. Na primeira parte, Ruben de Mattos defende a criação de dispositivos para a elevação progressiva dos gastos públicos em saúde. Segundo o debatedor, o maior desafio do governo será viabilizar - e sustentar - um sistema que garanta, de fato, o acesso universal e igualitário. Mattos também destaca a importância dos repasses federais entre os níveis de governos, por vê-los como instrumentos capazes de reduzir as desigualdades entre as regiões e incentivar políticas que contribuam para a consolidação do SUS. Na segunda parte, Nilson do Rosário afirma que o ajuste fiscal da década de 1990, conseqüência da política de estabilização monetária, limitou a capacidade de financiamento governamental na atenção à saúde, gerando efeitos perversos devido à ampliação da desigualdade social. A seguir, explica como o setor saúde respondeu às exigências de ajuste macroeconômico nas despesas públicas através de estratégias substitutivas, contexto em que o Programa de Saúde da Família (PSF se expandiu rapidamente, tornando-se estratégico na agenda da ampliação da atenção ambulatorial básica do país.This work discusses some of the issues related to the funding of the Brazilian National Health Service (SUS. In the first part of the paper, Ruben de Mattos advocates the creation of devices to guarantee a progressive increase in the public health budget. In the debater's view, the greatest challenge facing the government is the development - and the maintenance - of a system that can de facto guarantee universal and equalitarian access. Mattos also emphasizes the importance of the federal government's transfers of funds to local governments since the latter are seen as instrumental in the attempts to reduce inequality between regions and to encourage policies that will contribute to the SUS' consolidation. In the second part, Nilson

UN PRIVILEGIO PARA EL ESTADO DE MICHOACÁN: SUS PUEBLOS MÁGICOS

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Horacio Mercado Vargas

2013-06-01

Full Text Available El Estado de Michoacán, que se ubica en la parte del extremo sur occidental de México, posee paisajes muy hermosos: de bosques, praderas y lagunas de gran belleza, montañas y volcanes que descienden hacia el mar. Es uno de los más ricos en recursos naturales. La Secretaría de Turismo, diversas entidades del gobierno federal y gobiernos estatales y municipales desarrollaron el Programa de Pueblos Mágicos, para darle un valor a ciertas poblaciones del país que tienen características culturales y que llaman la atención de los visitantes mexicanos y extranjeros. Michoacán es una entidad que por sus características culturales, se distingue del resto de las entidades, y por ello es el estado con mayor número de Pueblos Mágicos en todo el país. La belleza y cultura de Michoacán se puede constatar en sus Pueblos Mágicos, que siempre recordarán los visitantes. Sus formas, colores y tradiciones son expresiones de un pasado lleno de gloria que se manifiesta en el presente.

Las comunidades y sus revistas científicas

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Leonardo Romero

2014-03-01

Full Text Available Las investigaciones realizadas y expuestas ante las sociedades científicas, tuvieron en las revistas científicas un medio ex professode comunicación y diseminación de sus memorias y descubrimientos. Sin embargo en el escenario actual los investigadores y las revistas científicas adoptan nuevas características y se ven influenciadas por diferentes tendencias que requieren una estrategia de desarrollo editorial adecuada.

Effect of laser beam position on mechanical properties of F82H/SUS316L butt-joint welded by fiber laser

Energy Technology Data Exchange (ETDEWEB)

Serizawa, Hisashi, E-mail: serizawa@jwri.osaka-u.ac.jp [Joining and Welding Research Institute, Osaka University, 11-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Mori, Daiki; Ogiwara, Hiroyuki; Mori, Hiroaki [Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan)

2014-10-15

Highlights: • The micro hardness of weld metal in F82H/SUS316L joint partially decreases after PWHT by shifting beam position to SUS316L. • Charpy impact energy of F82H/SUS316L joint obviously increases after PWHT due to the release of residual stress. • The tensile strength of weld metal in F82H/SUS316L joint is higher than that of SUS316L. • The fiber laser welding seems to be one of the most candidate methods to join between F82H and SUS316L pipes practically. - Abstract: A dissimilar butt-joint between reduced activation ferritic/martensitic steel F82H and SUS316L austenitic stainless steel was made by 4 kW fiber laser and the influence of laser beam position on its mechanical properties before and after post-weld heat treatment (PWHT) was examined at room temperature. From the nano-indentation measurements and the microstructural observations, it is found that the micro hardness of weld metal partially decreases after PWHT by shifting beam position to SUS316L because its phase seems to move from only the martensitic phase to the mixture of austenitic and martensitic phases. In addition, Charpy impact test suggests that the impact energy slightly increases by shifting beam position before PWHT and obviously increases after PWHT due to the release of residual stress. Moreover, the tensile test indicates that the tensile strength of weld metal is higher than that of SUS316L and the fracture occurs at the base metal of SUS316L regardless of laser beam position.

IDENTIFICATION AND CHARACTERIZATION OF THE SUCROSE SYNTHASE 2 GENE (Sus2 IN DURUM WHEAT

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Mariateresa eVolpicella

2016-03-01

Full Text Available Sucrose transport is the central system for the allocation of carbon resources in vascular plants. Sucrose synthase, which reversibly catalyzes sucrose synthesis and cleavage, represents a key enzyme in the control of the flow of carbon into starch biosynthesis. In the present study the genomic identification and characterization of the Sus2-2A and Sus2-2B genes coding for sucrose synthase in durum wheat (cultivars Ciccio and Svevo is reported. The genes were analyzed for their expression in different tissues and at different seed maturation stages, in four tetraploid wheat genotypes (Svevo, Ciccio, Primadur and 5-BIL42. The activity of the encoded proteins was evaluated by specific activity assays on endosperm extracts and their structure established by modelling approaches. The combined results of SUS2 expression and activity levels were then considered in the light of their possible involvement in starch yield.

Sustainability of public health in diadema, 2000 - 2011: a picture of SUS building limits

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Mariana Alves Melo

2015-12-01

Full Text Available Introduction: between 2000 to 2011, Diadema paulista municipality has faced many obstacles in health management, struggling to ensure the sustainability of its health system. Objective: to contribute to the discussion of the Unified Health System (SUS and its foreseable turbulent future, based on the analysis of the municipal point of view, identifying the limits of its building in Diadema. Methods: Diadema is characterized as one of the first municipalities that adhered to the principles of the SUS, since its implementation, allowing an analysis as a case study in view of the system's sustainability at the local level. The term sustainability used was addressed in two dimensions: the structure of this system and its process. Results: in SUS implementation period, Diadema stood out by increasing investment in health, reaching an average allocation of about 30% of its tax revenues, including constitutional transfers. Results diagnosed by observing the structure of dimensions and the process indicate that the sustainability of the municipal health system is threatened, as the significant expansion of the range of services and health actions was not followed by sufficient resources to its health maintenance. Conclusions: the existence of obstacles justified and formed the basis for the diagnosis of the main limits on SUS conformation, in health policy and management of resources, funding and budgetary impacts.

Sindicalismo, SUS e planos de saúde Trade unionism, Unified Health System (SUS and private health insurance

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José Augusto Pina

2006-09-01

Full Text Available Este artigo discute a interlocução do sindicalismo brasileiro com o Sistema Único de Saúde (SUS e os planos e seguros privados de saúde. São ponderadas algumas teses na Saúde Coletiva à luz de estudos mais recentes nas Ciências Sociais sobre o sindicalismo e realizada análise documental para o caso da Central Única dos Trabalhadores (CUT, tomado aqui como referência. Aponta-se a necessidade de considerar os pesos relativos que a ação sindical atribuiu a cada um dos aspectos da relação, SUS e planos privados de saúde, pelas distintas conjunturas do país. O conflito entre trabalhadores e empresas somado ao desemprego e à precarização do trabalho expõe os limites das coberturas assistenciais privadas e impele a representação sindical a pleitear a intervenção estatal. O trabalho refletiu sobre as distintas modalidades de ação sindical na empresa e no Estado. A complexidade dessa dinâmica fez emergir um setor sindical interessado na gestão da previdência complementar e dos planos de saúde e, ao mesmo tempo, recria as circunstâncias e traz novas possibilidades de as organizações sindicais se colocarem na cena política e aglutinar os interesses de amplos segmentos dos trabalhadores para pressionar o Estado na defesa da melhoria do sistema público de saúde.The article intends to discuss the patterns of interlocution between the Brazilian trade unionism, the public health system (SUS and the private health insurance sector. Some thesis originated in the Public Health area about the subject are debated, in the light of more recent Social Science's studies concerned the Brazilian unionism. It presents a documentary analysis for the case of the largest National Workers Organization, named CUT. The need to discuss the problem in distinct political and economic conjunctures of the country is pointed out. The conflicts between the workers and the companies, added to the unemployment and deregulation of the labor markets

Effectiveness of Adaptive Contextual Learning Model of Integrated Science by Integrating Digital Age Literacy on Grade VIII Students

Science.gov (United States)

Asrizal, A.; Amran, A.; Ananda, A.; Festiyed, F.

2018-04-01

Educational graduates should have good competencies to compete in the 21st century. Integrated learning is a good way to develop competence of students in this century. Besides that, literacy skills are very important for students to get success in their learning and daily life. For this reason, integrated science learning and literacy skills are important in 2013 curriculum. However, integrated science learning and integration of literacy in learning can’t be implemented well. Solution of this problem is to develop adaptive contextual learning model by integrating digital age literacy. The purpose of the research is to determine the effectiveness of adaptive contextual learning model to improve competence of grade VIII students in junior high school. This research is a part of the research and development or R&D. Research design which used in limited field testing was before and after treatment. The research instruments consist of three parts namely test sheet of learning outcome for assessing knowledge competence, observation sheet for assessing attitudes, and performance sheet for assessing skills of students. Data of student’s competence were analyzed by three kinds of analysis, namely descriptive statistics, normality test and homogeneity test, and paired comparison test. From the data analysis result, it can be stated that the implementation of adaptive contextual learning model of integrated science by integrating digital age literacy is effective to improve the knowledge, attitude, and literacy skills competences of grade VIII students in junior high school at 95% confidence level.

Evaluation of the integrity of reactor vessels designed to ASME Code, Sections I and/or VIII

International Nuclear Information System (INIS)

Hoge, K.G.

1976-01-01

A documented review of nuclear reactor pressure vessels designed to ASME Code, Sections I and/or VIII is made. The review is primarily concerned with the design specifications and quality assurance programs utilized for the reactor vessel construction and the status of power plant material surveillance programs, pressure-temperature operating limits, and inservice inspection programs. The following ten reactor vessels for light-water power reactors are covered in the report: Indian Point Unit No. 1, Dresden Unit No. 1, Yankee Rowe, Humboldt Bay Unit No. 3, Big Rock Point, San Onofre Unit No. 1, Connecticut Yankee, Oyster Creek, Nine Mile Point Unit No. 1, and La Crosse

Understanding the first Neolithic occupation of Cova d'En Pardo (Planes, Alicante: Preliminary results of the multidisciplinary analysis of levels VIII and VIIIB

Directory of Open Access Journals (Sweden)

Jorge Agatángelo Soler Díaz

2014-01-01

Full Text Available We present the results of excavations carried out in the Cova d'En Pardo (Planes, Alicante, specifically the levels VIII and VIIIb. The development of a multidisciplinary project has allowed to us characterize the occupation of a small cavity by the first farming communities associated with the Neolithization process of the east of Iberian Peninsula.

Aspectos fisiológicos del catión cinc y sus implicaciones cardiovasculares

OpenAIRE

Díaz García, Carlos Manlio; Álvarez González, Julio L.

2009-01-01

Introducción La versatilidad del catión cinc en la fisiología de diversos tipos celulares ha conllevado a una creciente atención de la comunidad científica sobre sus roles funcionales y la regulación a la que se encuentran sus niveles. Objetivos Presentar una revisión bibliográfica sobre el tema, con énfasis en las implicaciones cardiovasculares de este catión. Fuente de Datos El buscador Pubmed del Servicio Central de Información Biotecnológica de los Institutos Nacionales para la Ciencia, c...

Seleucid, Demotic and Mediterranean mathematics versus Chapters VIII and IX of the Nine Chapters: accidental or significant similarities?

DEFF Research Database (Denmark)

Høyrup, Jens

Similarities of geometrical diagrams and arithmetical structures of problems have often been taken as evidence of transmission of mathematical knowledge or techniques between China and “the West”. Confronting on one hand some problems from Chapter VIII of the Nine Chapters with comparable problems...... known from Ancient Greek sources, on the other a Seleucid collection of problems about rectangles with a subset of the triangle problems from Chapter IX, it is concluded, (1) that transmission of some arithmetical riddles without method – not “from Greece” but from a transnational community of traders...

Human parvovirus B19 infection in hemophiliacs first infused with two high-purity, virally attenuated factor VIII concentrates.

Science.gov (United States)

Azzi, A; Ciappi, S; Zakvrzewska, K; Morfini, M; Mariani, G; Mannucci, P M

1992-03-01

Human parvovirus B19 can be transmitted by coagulation factor concentrates and is highly resistant to virucidal methods. To evaluate whether the additional removal of virus by chromatographic methods during the manufacture of high-purity concentrates reduces the risk of B19 transmission, we have prospectively evaluated the rate of anti-B19 seroconversion in two groups of susceptible (anti-B19 negative) hemophiliacs infused with high-purity, heated (pasteurized) or solvent-detergent-treated factor VIII concentrates. Both products infected a relatively high proportion of patients (nine of 20).

PENGARUH PENGGUNAAN VARIASI METODE DAN MODEL PEMBELAJARAN TERHADAP HASIL BELAJAR FISIKA SISWA KELAS VIII SMPN2 MARGATIGA SEMESTER GENAP TP 2013/2014

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Eni Fitriani

2015-03-01

Full Text Available The purpose of this study was to investigate the effect of variations in the methods and models of teaching to student learning outcomes VIII SMPN2 MARGA TIGA.This research is experimental research which ofdesign completely randomized or completely randomized experimental design.The population in thisresearch is all of student VIII class in SMPN 2 MARGA TIGA2013/2014. The sample in this research is VIIIth class which totaling 34 students.In this research, conducted with three treatments of learning in a classroom.Data collection techniques in this research use the technique of the test, which tests the end (posttest were then analyzed with the test results hipotesis. From posttest analysis results of hypothesis testing using one-way ANOVA test (Completely Randomized Design at the 5% significance level value obtained results Fobs = 1.5244 and Ftab = 3.10 this shows that H0 is accepted and means variety of methods and learning models provide a similar impact on student learning outcomes.It can be concluded that all three treatments had similar quality if tailored to the needs of all three materials. 

Computed tomography in Brazil: frequency and pattern of usage among inpatients of the Unified Health System (SUS); Tomografia computadorizada no Brasil: frequencia e padrao de uso em pacientes internados no Sistema Unico de Saude (SUS)

Energy Technology Data Exchange (ETDEWEB)

Dovales, Ana Cristina M.; Souza, Andressa A. de; Veiga, Lene H.S., E-mail: adovales@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2015-04-15

This paper shows the frequency, pattern and trend of computed tomography use in inpatients of the Brazilian public health care system (SUS), from 2008 to 2011. Data were extracted from an Internet database provided by SUS. Head/neck examinations were the most frequent type of CT over the study period. The use of CT increased over time, with the greatest increase being observed for CT of extremities. (author)

Analisis Deskriptif Soal Geometri dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama Kelas VIII Berdasarkan Kriteria International Assessment TIMSS 2007

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Etik Rahayu

2012-06-01

Full Text Available Tujuan penelitian ini adalah untuk mendeskripsikan  domain kognitif dan aspek kognitif (required behavior soal matematika dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama (SMP Kelas VIII berdasarkan kriteria International Assessment TIMSS 2007 dan proporsinya. Metode penelitian yang digunakan adalah deskriptif kualitatif, dengan subjek penelitian adalah soal geometri dalam Buku Matematika Bilingual SMP. yang berjudul “Mathematics for Junior High School Grade VIII 1st Semester” dan “Mathematics for Junior High School Grade VIII 2nd Semester” karangan karangan M. Cholik Adinawan dan Sugijono. Pengumpulan data menggunakan metode observasi dan wawancara tentang penggunaan buku matematika bilingual yang paling banyak digunakan di kota semarang. Pedoman analisis soal berdasarkan kriteria International Assessment TIMSS 2007, dengan validasi hasil oleh ahli. Hasil penelitian menunjukkan bahwa soal yang dianalisis memuat satu hingga tujuh aspek kognitif. Sebagian besar soal memuat 4 aspek kognitif yaitu 44.04 %, diikuti soal dengan 3 aspek kognitif  yaitu 36, 42%,  soal dengan 2 aspek kognitif yaitu 14, 90%, kemudian 1,99% untuk soal dengan 1 atau 5 aspek kognitif, dan 0,33% untuk soal dengan 6 atau 7 aspek kognitif. Proporsi tinggi pada recall (28.26% dan compute (26.57%, diikuti dengan SRP (10.85%, implement (10.65%, retrieve (8.36%, recognize (6.17%, analyze (1.99%, measure (1.59%, generalize (1.09%, SNRP (1.00%, classify (0.80%, represent (0.80%, justify (0.80%, select (0.60%, model (0.30%, synthesis (0.20%. Secara keseluruhan berdasarkan International Assessment TIMSS 2007 soal yang termasuk domain knowing memiliki persentase paling tinggi (52.28%, domain knowing-applying (24.83%, domain knowing- reasoning (12.91%, dan hanya sedikit yang termasuk domain knowing-apllying-reasoning (3.97%. Serta terdapat 4 soal (1.32% yang mempunyai ketidaksesuaian penggunaan mathematics terms serta 1 soal (0

Docentes de inglés de primaria, secundaria y terciaria: Sus creencias pedagógicas sobre sus estudiantes

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Claudio Díaz-Larenas

2015-01-01

Full Text Available Como agente reflexivo de su propia práctica, el profesorado construye creencias pedagógicas sobre el proceso de enseñanza y aprendizaje y, en particular, sobre el rol que sus estudiantes deben asumir en el aprendizaje de un idioma. Este estudio tiene como objetivo identificar las creencias pedagógicas de treinta docentes de inglés de primaria, secundaria y terciaria, en Chile, sobre el rol estudiantil en el proceso didáctico. Un cuestionario, una entrevista semi-estructurada, un diario auto-biográfico y cinco diarios de observación no-participante fueron utilizados para revelar las creencias pedagógicas de sus informantes. Los datos arrojados por los instrumentos fueron analizados con el programa cualitativo ATLASTI, que permitió el levantamiento de tres dimensiones y diez categorías, mediante el uso de la técnica del análisis de contenido semántico. Los resultados muestran que los tres grupos de profesorado declaran que estudiantes que aprenden una lengua extranjera deben tener características personales y académicas relacionadas con la motivación, la participación, la autonomía, entre otras; sin embargo, al interior del aula asumen un rol pasivo y reactivo frente al ambiente de enseñanza altamente estructurado que genera el personal docente. En conclusión, las creencias que cada docente sostiene se alimentan de la teoría y se corroboran o cuestionan en la práctica de aula, a modo de una relación bidireccional entre teoría y práctica, y viceversa.

Daniel Link y la clase: problemas de convivencia

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Mariana Catalin

2016-12-01

Full Text Available El presente trabajo busca realizar un acercamiento a los modos de la producción ensayística de Daniel Link a partir de un interrogante que cruza toda su producción: la pregunta por cómo vivir juntos. Para esto, en una primera instancia, se realiza un análisis de la aparición explícita del interrogante en una serie de textos del blog del autor (linkillo.blogspot.com, para observar qué problemas se condensan en torno al mismo. A partir de este contexto, en un segundo momento, se abre un recorrido por dos de sus más recientes libros de ensayos, Clases. Literatura y disidencia (2005 y Fantasmas. Imaginación y sociedad (2009. Allí, además de los usos que se articulan a partir de su aparición explícita, el interrogante permite pensar la relación entre clasificación y cualificación, dos conceptos centrales en la producción de Link.

On existence and properties of plutonium(VIII) derivatives

Energy Technology Data Exchange (ETDEWEB)

Kiselev, Yu.M.; Dolzhenko, V.D.; Ermilov, A.Yu. [Moscow State Univ. (Russian Federation). Chemistry Dept.; Nikonov, M.V.; Myasoedov, B.F. [Russian Academy of Science, Moscow (Russian Federation). Inst. of Geochemistry and Analytical Chemistry; Tananaev, I.G. [Russian Academy of Science, Moscow (Russian Federation). Inst. of Physical Chemistry and Electrochemistry

2014-04-01

The existence of Pu(VIII) was shown in alkaline solutions and in nonpolar solvents (CCl{sub 4} and CHCl{sub 3}) on the ground of such experimental facts like extraction of plutonium species, obtained by means of ozonization of Pu(VI) alkaline solutions into CCl{sub 4} and CHCl{sub 3}; volatility of Pu compounds out of aqueous alkaline solutions, and the mentioned solvents. The product of interaction between PuO{sub 3}.0.8H{sub 2}O and XeF{sub 2} in CCl{sub 4} and CHCl{sub 3} was of the same chemical form for both cases and identical with the form of the product of volatility of Pu out of these organic solutions. The electronic absorbance spectra of these products in CCl{sub 4} and CHCl{sub 3} were fairly similar to the ones for OsO{sub 4} and RuO{sub 4}. The band of absorption in these spectra with the maximum at 332 nm corresponds to the charge transfer of metal-ligand type [π(O)→Pu], as the value of molar extinction coefficient e was found to be higher than 2 x 10{sup 3} L/mole cm. A satisfactory agreement between the energies for the transitions of PuO{sub 4} molecule designed by X{sub α}-SW method and experimental data was observed. A similar accordance was observed for the designed vibration frequency (DFT-method) with the one found as result of analysis of the vibration structure of the experimental spectra. (orig.)

Representaciones y sus impactos: el caso de los lacandones en la Selva Lacandona

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Tim Trench

2005-02-01

Full Text Available Las representaciones “positivas” de los lacandones les ofrecen ventajas claras a corto plazo, confiriendo cierto capital simbólico y político en sus relaciones con foráneos y en sus diversas luchas, además de variados beneficios económicos. Pero, a final de cuentas, es cuestionable si su imagen como pueblo “originario” y conservacionista “innato” les ayude en el largo plazo, ya que forma parte de un discurso fundamentalmente colonialista y puede limitar las oportunidades de las comunidades lacandonas a decidir su futuro y definir el carácter de su inserción en la sociedad nacional.

La violencia de hijos adolescentes contra sus progenitores La violencia de hijos adolescentes contra sus progenitores

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Concepción Aroca Montolío

2013-10-01

Full Text Available According to Prosecutor’s Office of the Minor, the accusation interposed by mothers and/or fathers victims by theirs children, along 2007 were 2603, in 2008 amounted 4.211, in 2009 there were 5.209 and in 2010 there were 8.000 accusations. Suede this worrying increase, the principal aim of our article is to check the scientific international and national documentation, from 1957 until the year 2010 that analyses the phenomenon of the adolescent violence against parents, to achieve an approximation to its keys that there allows us the comprehension and analysis of this serious familiar problem. For it we will analyse: (a the importance of this crime by means of criminological mediators: prevalence and incidence; (b the age and sex variables’ aggressors to be able to establish a basic profile about theirs and, (c the violence types that the teenagers wield to damage, prejudice and suffering against their progenitors, with the aim to obtain what they want. The information obtained in this research review and qualitative analysis, change in base to the methodology used and the type of sample under study to obtain conclusions. Even though, we wantto do research into needs to investigate this type of familiar violence, and from there, to do researches with rigorous scientific methodologies, unifying criteria and variables to be investigating, to be able to anticipate in this increasing problem that the parents have. Según la Fiscalía del Menor en el año 2007, las denuncias interpuestas por madres y/o padres, víctimas de malos tratos por sus hijos e hijas menores de edad, fueron 2.683. En 2008 ascendieron a 4.211, en 2009 se presentaron 5.209 y en el año 2010 se registraron 8.000 denuncias. Ante éste preocupante incremento, el objetivo principal de nuestro artículo es revisar la documentación científica que analiza la violencia filio-parental,  desde 1957 hasta el año 2011, para lograr una aproximación a sus claves que nos permita la

ENDF/B-VIII.0: The 8th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data

Science.gov (United States)

Brown, D. A.; Chadwick, M. B.; Capote, R.; Kahler, A. C.; Trkov, A.; Herman, M. W.; Sonzogni, A. A.; Danon, Y.; Carlson, A. D.; Dunn, M.; Smith, D. L.; Hale, G. M.; Arbanas, G.; Arcilla, R.; Bates, C. R.; Beck, B.; Becker, B.; Brown, F.; Casperson, R. J.; Conlin, J.; Cullen, D. E.; Descalle, M.-A.; Firestone, R.; Gaines, T.; Guber, K. H.; Hawari, A. I.; Holmes, J.; Johnson, T. D.; Kawano, T.; Kiedrowski, B. C.; Koning, A. J.; Kopecky, S.; Leal, L.; Lestone, J. P.; Lubitz, C.; Márquez Damián, J. I.; Mattoon, C. M.; McCutchan, E. A.; Mughabghab, S.; Navratil, P.; Neudecker, D.; Nobre, G. P. A.; Noguere, G.; Paris, M.; Pigni, M. T.; Plompen, A. J.; Pritychenko, B.; Pronyaev, V. G.; Roubtsov, D.; Rochman, D.; Romano, P.; Schillebeeckx, P.; Simakov, S.; Sin, M.; Sirakov, I.; Sleaford, B.; Sobes, V.; Soukhovitskii, E. S.; Stetcu, I.; Talou, P.; Thompson, I.; van der Marck, S.; Welser-Sherrill, L.; Wiarda, D.; White, M.; Wormald, J. L.; Wright, R. Q.; Zerkle, M.; Žerovnik, G.; Zhu, Y.

2018-02-01

We describe the new ENDF/B-VIII.0 evaluated nuclear reaction data library. ENDF/B-VIII.0 fully incorporates the new IAEA standards, includes improved thermal neutron scattering data and uses new evaluated data from the CIELO project for neutron reactions on 1H, 16O, 56Fe, 235U, 238U and 239Pu described in companion papers in the present issue of Nuclear Data Sheets. The evaluations benefit from recent experimental data obtained in the U.S. and Europe, and improvements in theory and simulation. Notable advances include updated evaluated data for light nuclei, structural materials, actinides, fission energy release, prompt fission neutron and γ-ray spectra, thermal neutron scattering data, and charged-particle reactions. Integral validation testing is shown for a wide range of criticality, reaction rate, and neutron transmission benchmarks. In general, integral validation performance of the library is improved relative to the previous ENDF/B-VII.1 library.

ENDF/B-VIII.0: The 8 th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data

Energy Technology Data Exchange (ETDEWEB)

Brown, D. A.; Chadwick, M. B.; Capote, R.; Kahler, A. C.; Trkov, A.; Herman, M. W.; Sonzogni, A. A.; Danon, Y.; Carlson, A. D.; Dunn, M.; Smith, D. L.; Hale, G. M.; Arbanas, G.; Arcilla, R.; Bates, C. R.; Beck, B.; Becker, B.; Brown, F.; Casperson, R. J.; Conlin, J.; Cullen, D. E.; Descalle, M. -A.; Firestone, R.; Gaines, T.; Guber, K. H.; Hawari, A. I.; Holmes, J.; Johnson, T. D.; Kawano, T.; Kiedrowski, B. C.; Koning, A. J.; Kopecky, S.; Leal, L.; Lestone, J. P.; Lubitz, C.; Márquez Damián, J. I.; Mattoon, C. M.; McCutchan, E. A.; Mughabghab, S.; Navratil, P.; Neudecker, D.; Nobre, G. P. A.; Noguere, G.; Paris, M.; Pigni, M. T.; Plompen, A. J.; Pritychenko, B.; Pronyaev, V. G.; Roubtsov, D.; Rochman, D.; Romano, P.; Schillebeeckx, P.; Simakov, S.; Sin, M.; Sirakov, I.; Sleaford, B.; Sobes, V.; Soukhovitskii, E. S.; Stetcu, I.; Talou, P.; Thompson, I.; van der Marck, S.; Welser-Sherrill, L.; Wiarda, D.; White, M.; Wormald, J. L.; Wright, R. Q.; Zerkle, M.; Žerovnik, G.; Zhu, Y.

2018-02-01

We describe the new ENDF/B-VIII.0 evaluated nuclear reaction data library. ENDF/B-VIII.0 fully incorporates the new IAEA standards, includes improved thermal neutron scattering data and uses new evaluated data from the CIELO project for neutron reactions on 1H, 16O, 56Fe, 235U, 238U and 239Pu described in companion papers in the present issue of Nuclear Data Sheets. The evaluations benefit from recent experimental data obtained in the U.S. and Europe, and improvements in theory and simulation. Notable advances include updated evaluated data for light nuclei, structural materials, actinides, fission energy release, prompt fission neutron and γ-ray spectra, thermal neutron scattering data, and charged-particle reactions. Integral validation testing is shown for a wide range of criticality, reaction rate, and neutron transmission benchmarks. In general, integral validation performance of the library is improved relative to the previous ENDF/B-VII.1 library.

Capítulo VIII: heredabilidad del rendimiento y sus componentes en tomate, Lycopersicon esculentum, Mill.; correlaciones genéticas y ambientales

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Lobo Arias Mario

1994-12-01

Full Text Available

El presente estudio se desarrolló con el fin de determinar la heredabilidad, en sentido amplio, del rendimiento y sus componentes en tomate y a la vez describir las relaciones genotípicas y ambientales para dichos componentes en una población constituida por tres líneas endocriadas (Ponderosa Red, Chonto y Red Cherry como progenitores y las F₁ provenientes de los cruzamientos entre los progenitores en una sola dirección. La heredabilidad se estimó en base a los cuadrados medios esperados del análisis de varianza y las correlaciones genotípicas y ambientales en base a los cuadrados medios esperados del análisis de varianza y productos cruzados medios del análisis de covarianza. Para el rendimiento se estimó una heredabilidad de 79.3%, para el número total de frutos de 93.107%, para peso promedio de de fruto de 4.25%. Los coeficientes de correlación genotípicos estimados fueron: para número de frutos por planta y peso promedio de frutos de -0.985; para número de inflorescencias por planta y número de frutos por inflorescencia de 0,541; para número de lóculos por fruto y peso promedio de lóculos de 0.826. Los coeficientes de correlación ambiental estimados fueron: para número de frutos por planta y peso promedio de frutos de -0.512; para rendimiento y número de frutos por planta de -0.065; para rendimiento y peso promedio de frutos de 0.613; para número de inflorescencias y número de frutos por inflorescencias de -0.878; para número de lóculos por fruto y peso promedio de lóculos de -0.779. Lo anterior indica que el método de mejoramiento para rendimiento, dentro de la población estudiada, seria la selección, tomando como índice de selección apropiado el peso promedio de frutos pero sin descuidar el número de frutos. Se debe maximizar las condiciones favorables de suelo y manejo de cultivo para permitir una adecuada manifestación de los dos componentes primarios del rendimiento.

This study

Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice.

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Marina E Fomin

Full Text Available Liver sinusoidal endothelial cells (LSECs form a semi-permeable barrier between parenchymal hepatocytes and the blood. LSECs participate in liver metabolism, clearance of pathological agents, immunological responses, architectural maintenance of the liver and synthesis of growth factors and cytokines. LSECs also play an important role in coagulation through the synthesis of Factor VIII (FVIII. Herein, we phenotypically define human LSECs isolated from fetal liver using flow cytometry and immunofluorescence microscopy. Isolated LSECs were cultured and shown to express endothelial markers and markers specific for the LSEC lineage. LSECs were also shown to engraft the liver when human fetal liver cells were transplanted into immunodeficient mice with liver specific expression of the urokinase-type plasminogen activator (uPA transgene (uPA-NOG mice. Engrafted cells expressed human Factor VIII at levels approaching those found in human plasma. We also demonstrate engraftment of adult LSECs, as well as hepatocytes, transplanted into uPA-NOG mice. We propose that overexpression of uPA provides beneficial conditions for LSEC engraftment due to elevated expression of the angiogenic cytokine, vascular endothelial growth factor. This work provides a detailed characterization of human midgestation LSECs, thereby providing the means for their purification and culture based on their expression of CD14 and CD32 as well as a lack of CD45 expression. The uPA-NOG mouse is shown to be a permissive host for human LSECs and adult hepatocytes, but not fetal hepatoblasts. Thus, these mice provide a useful model system to study these cell types in vivo. Demonstration of human FVIII production by transplanted LSECs encourages further pursuit of LSEC transplantation as a cellular therapy for the treatment of hemophilia A.

Los consejos escolares de los colegios de educación primaria analizados por sus miembros

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José Fernando González Granda

2004-01-01

Full Text Available En este trabajo presentamos la valoración que de los consejos escolares de los colegios de educación primaria de la Comunidad Autónoma de Asturias realizan sus miembros. Se analizan las principales características de los consejeros así como la información y atención que éstos prestan a sus representados. Se valora el funcionamiento de los consejos y cómo cumplen éstos las competencias que tienen asignadas. También recogemos la valoración que los consejeros realizan de los problemas que tienen en el cumplimiento de sus tareas. Los consejeros valoran cómo los consejos mejoran el funcionamiento de los colegios y diversos aspectos relacionados con la participación, asi como la satisfacción de los distintos miembros de la comunidad escolar respecto al funcionamiento de los consejos escolares.

[Methodology for construction of a panel of indicators for monitoring and evaluation of unified health system (SUS) management].

Science.gov (United States)

Tamaki, Edson Mamoru; Tanaka, Oswaldo Yoshimi; Felisberto, Eronildo; Alves, Cinthia Kalyne de Almeida; Drumond Junior, Marcos; Bezerra, Luciana Caroline de Albuquerque; Calvo, Maria Cristina Marino; Miranda, Alcides Silva de

2012-04-01

This study sought to develop methodology for the construction of a Panel for the Monitoring and Evaluation of Management of the Unified Health System (SUS). The participative process used in addition to the systematization conducted made it possible to identify an effective strategy for building management tools in partnership with researchers, academic institutions and managers of the SUS. The final systematization of the Panel selected indicators for the management of the SUS in terms of Demand, Inputs, Processes, Outputs and Outcomes in order to provide a simple, versatile and useful tool for evaluation at any level of management and more transparent and easier communication with all stakeholders in decision-making. Taking the management of the SUS as the scope of these processes and practices in all normative aspects enabled dialog between systemic theories and those which consider the centrality of the social actor in the decision-making process.

Sucesos estresantes y sus impactos en mujeres y jóvenes de la comunidad de cuitzeo, Michoacán: El ciclo de la migración México-EUA en sus familias

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Nydia Obregón-Velasco

Full Text Available El presente trabajo describe algunos sucesos de vida estresantes y los impactos que tienen en la salud de las mujeres y sus hijos jóvenes, a partir de la migración hacia EUA de algunos de sus familiares directos, lo cual favorece el ciclo de migración en la familia. Se utilizó la metodología cualitativa con un enfoque de participación-acción, aplicando grupos focales, entrevistas y observación participante durante diferentes actividades realizadas en la comunidad de Cuitzeo, Michoacán, tales como conferencias y talleres.

Factor VIII brand and the incidence of factor VIII inhibitors in previously untreated UK children with severe hemophilia A, 2000-2011

Science.gov (United States)

Palmer, Benedict P.; Chalmers, Elizabeth A.; Hart, Daniel P.; Liesner, Ri; Rangarajan, Savita; Talks, Katherine; Williams, Michael; Hay, Charles R. M.

2014-01-01

The effect of recombinant factor VIII (rFVIII) brand on inhibitor development was investigated in all 407 severe hemophilia A previously untreated patients born in the United Kingdom (UK) between 1 January 2000 and 31 December 2011. Eighty-eight (22%) had been in the RODIN study. Information was extracted from the National Haemophilia Database. Because exposure days (EDs) were not known for some patients, time from first treatment was used as a surrogate for rFVIII exposure. An inhibitor developed in 118 (29%) patients, 60 high and 58 low titer, after a median (interquartile range) of 7.8 (3.3-13.5) months from first exposure and 16 (9-30) EDs. Of 128 patients treated with Kogenate Bayer/Helixate NexGen, 45 (35.2%, 95% confidence interval [CI] 27.4-43.8) developed an inhibitor compared with 42/172 (24.4%, 95% CI 18.6% to 31.4%) with Advate (P = .04). The adjusted hazard ratio (HR) (95% CI) for Kogenate Bayer/Helixate NexGen compared with Advate was 2.14 (1.12-4.10) (P = .02) for high titer and 1.75 (1.11-2.76) (P = .02) for all inhibitors. When excluding UK-RODIN patients, the adjusted HR (95% CI) for high-titer inhibitors was 2.00 (0.93-4.34) (P = .08). ReFacto AF was associated with a higher incidence of all, but not high-titer, inhibitors than Advate. These results will help inform debate around the relative immunogenicity and use of rFVIII brands. PMID:25339360

Adolescentes consumidores de televisión: autopercepciones sobre sus derechos

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María Ángeles Espinosa Bayal

2014-07-01

Full Text Available El artículo analiza la percepción que tiene una muestra representativa de la población española de entre 12 y 18 años sobre la protección de sus derechos en las cadenas de televisión. Para conseguir este objetivo, se aplicó un cuestionario de 59 preguntas diseñado para una investigación más amplia en la que se analizaba la opinión de los menores sobre la protección de sus derechos en la televisión y en Internet. Ninguna pregunta del cuestionario se refería a cadenas o programas concretos identificados por los investigadores y la información sobre estos partía de la propia opinión de los adolescentes. Los resultados que se presentan se refieren a los datos sobre televisión y, más concretamente, al respeto por los derechos fundamentales de los telespectadores en general, y de los de los menores en particular. De estos resultados se concluye que los adolescentes perciben claramente la vulneración de los derechos de igualdad, dignidad e intimidad, a la información objetiva veraz y plural y a la libre expresión y opinión –especialmente cuando ésta se refiere a los niños–. Igualmente muestran una postura crítica y de rechazo hacia los tipos de programas que no respetan sus derechos. Se propone utilizar esta capacidad crítica de los telespectadores desde una doble perspectiva: por una parte para crear escuela de ciudadanía y, por otra, para generar una sociedad más justa y equitativa.

SUS Brasil: a região de saúde como caminho

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Lenir Santos

2015-06-01

Full Text Available O presente artigo desenvolve o tema da necessidade de se regionalizar a descentralização no sentido de aglutinar o que esta supostamente poderia ter fracionado. Ao revisitar a diretriz constitucional da descentralização os autores propõem medidas que visem sua garantia ao lado de ferramentas administrativas que permitam a formação de regiões de saúde resolutivas em pelo menos 95% das necessidades de saúde do território regional, para garantir autonomia sanitária. Os autores propõem soluções que passam pela criação de pessoas jurídicas associativas regionais, resultantes da aglutinação dos entes federativos em região de saúde. Apontam ainda o que não deu certo no Sistema Único de Saúde - SUS Brasil em razão tanto de equívocos originados nas melhores intenções, quanto do oportunismo que esses equívocos geraram. Advogam os autores a necessidade de respostas jurídico-administrativas para um SUS de caráter interfederativo tanto na sua gestão, que exige compartilhamentos, quanto no seu financiamento, que se mantém interdependente também. Concluem que o único caminho para o SUS ser nacional, é regionalizá-lo e dotar a região de saúde de todo o instrumental necessário à gestão compartilhada, interfederativa e responsável.

Sistema de Informação em Saúde do Trabalhador: desafios e perspectivas para o SUS Occupational Health Information System: challenges and perspectives in the Brazilian Unified Health System (SUS

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Luiz Augusto Facchini

2005-12-01

Full Text Available O presente artigo identifica e discute alguns desafios e perspectivas relativos à implantação de um Sistema de Informações em Saúde do Trabalhador (SIST no âmbito do Sistema Único de Saúde (SUS. Os desafios para a coleta, produção e a análise de dados e a disseminação continuada de informações sobre o estado de saúde dos trabalhadores e seus determinantes são revisados. Há destaque para a necessidade de investimentos em capacitação de recursos humanos, articulação e harmonização das bases de dados de interesse à saúde do trabalhador, implantação de infra-estrutura de informática nos níveis locais e da coleta das informações na rede de serviços do SUS, e integração e articulação interministerial. A realização da 3ª Conferência Nacional de Saúde do Trabalhador e a recém aprovada Política Nacional de Segurança e Saúde do Trabalhador representam reforços importantes para o debate sobre a implantação do SIST e sua prioridade na agenda do SUS. A relativa sintonia entre as agendas de técnicos, pesquisadores, trabalhadores e lideranças sindicais na defesa comum de um sistema de informações também é vista como um apoio à implantação do SIST e seu efetivo controle social.This paper presents a review of challenges and perspectives regarding the development of an occupational health information system in the Brazilian Unified Health System (SUS. It stress the need to set up a process of continuous data collection, processing, analyzing and communication of information on worker’s health and its determinants, emphasizing occupational risks. The paper also address the need to support the training of health workers. It is also recommended to take into consideration the feasibility of database standardization that allows linkage and, improvement in the information technologies utilized in health services, especially in community health centers, following a coordinated state action. Both, the 3rd

Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A.

Science.gov (United States)

Young, G; Mahlangu, J; Kulkarni, R; Nolan, B; Liesner, R; Pasi, J; Barnes, C; Neelakantan, S; Gambino, G; Cristiano, L M; Pierce, G F; Allen, G

2015-06-01

Prophylactic factor replacement, which prevents hemarthroses and thereby reduces the musculoskeletal disease burden in children with hemophilia A, requires frequent intravenous infusions (three to four times weekly). Kids A-LONG was a phase 3 open-label study evaluating the safety, efficacy and pharmacokinetics of a longer-acting factor, recombinant factor VIII Fc fusion protein (rFVIIIFc), in previously treated children with severe hemophilia A (endogenous FVIII level of hemophilia A. © 2015 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

Las pseudociencias como problema social en la era tecnocientífica. Un recorrido por la ciencia y sus enemigos dentro y fuera

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Jesús A. Valero-Matas

2017-10-01

Full Text Available El presente artículo se ocupa del tema de las pseudociencias como un problema social de la actualidad que es necesario analizar desde sus bases teóricas, sus antecedentes históricos y sus nuevos espacios de disputa. En este recorrido por la ciencia y sus enemigos, se evidencia que la proliferación de estos movimientos no puede entenderse sin tomar en consideración diversos actores, entre los que destacan los medios de comunicación, mediante su tarea de divulgación científica; las grandes empresas, especialmente las corporaciones farmacéuticas; los intelectuales, como inspiradores de esos grupos anticiencia; y por supuesto, los gobiernos y sus políticas.

Plasticity-induced martensitic transformation in austenitic stainless steels SUS 304 and SUS 316 L at room and liquid nitrogen temperatures. Quantitative measurement using X-ray diffraction method

International Nuclear Information System (INIS)

Iwasaki, Yoshifumi; Nakasone, Yuji; Shimizu, Tetsu; Kobayashi, Noboru

2006-01-01

The present study investigates plasticity-induced martensitic transformation in two types of austenitic stainless steels SUS 304 and 316 L subjected to uniform tensile stresses at room and liquid nitrogen temperatures. The X-ray diffraction method was used in order to measure volume fractions of transformed α' and ε' martensitic phases and to obtain the dependence of the volume fractions of these phases on the applied strain level ε. The difficulty in the measurement of the martensitic phases by the X-ray diffraction method caused by the preferred orientation which had been introduced during the rolling process and during the tensile tests was overcome by the help of Arnell's Method. Two types of target materials, i.e. Cu and Mo for the X-ray source were used to verify the accuracy and reproducibility of the present X-ray diffraction analyses. The results were also compared with those obtained by the saturation magnetization method using VSM, or vibrating-sample magnetometer reported elsewhere. It was revealed that α' was transformed in SUS 304 both at 297 and 77 K whereas in SUS 316L only at 77 K. Another type of martensitic phase, i.e., ε was transformed in the both steels only at 77 K. Almost the same values of the volume fractions of α' and ε' phases were obtained by the two types of target materials. The plots of α' volume fraction obtained by the X-ray diffraction methods vs. that by VSM showed a good linear correlation. (author)

COLONIZAÇÃO OU DIÁSPORAS? RESENHA C.-G. SCHWENTZEL (org., M. DANA, St.LEBRETON, Fr.PRÊTEUX, Les diásporas grecques VIII-III s. Paris, Atlande, 2012, 446 páginas, 25 euros. (Dossiê: O Mundo Antigo: Literatura e Historiografia

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José Antonio Dabdab Trabulsi

2015-09-01

Full Text Available C.-G. SCHWENTZEL (org., M. DANA, St.LEBRETON, Fr.PRÊTEUX, Les diásporas grecques VIII-III s. Paris, Atlande, 2012, 446 páginas, 25 euros.C.-G. SCHWENTZEL (org., M. DANA, St.LEBRETON, Fr.PRÊTEUX, Les diásporas grecques VIII-III s. Paris, Atlande, 2012, 446 páginas, 25 euros. Recebido em: 02/04/2015  – Aceito em 13/05/2015

LA CONCILIACIÓN PREPROCESAL EN EL SISTEMA PENAL ACUSATORIO Y SUS PRINCIPALES APORTES

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Dayana Becerra

2009-01-01

Full Text Available La aproximación que se efectúa en el presente estudio, inicia con un acercamiento al concepto de conciliación como mecanismo alternativo de resolución de conflictos, estableciendo los rasgos generales de esta figura; para posteriormente analizar el antecedente inmediato de la conciliación preprocesal en la ley 600 de 2.000, que abrió camino para concederle en materia penal a este mecanismo mayor importancia. Subsiguientemente se profundiza en la conciliación preprocesal consagrada expresamente en la ley 906 de 2004, y se analizan los cambios generados, para así conocer sus características, y determinar sus principales aportes, en el marco del sistema penal acusatorio.

Entusiastas, aficionados y espectadores: sus valores, motivaciones y compromiso

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Miquel Torregrosa

2009-01-01

Full Text Available El interés de las ciencias aplicadas al deporte en los espectadores y el espectáculo deportivo ha sido más bien escaso y en muchos casos sobrecentrado en la violencia. El objetivo de este trabajo es proponer una clasificación alternativa de los aficionados al fútbol a partir del tipo de contacto que tienen con el espectáculo y describir sus valores, motivaciones y compromiso. Mil setecientas diecinueve personas asistentes a partidos de fútbol organizados por la Liga de Fútbol Profesional contestaron cuestionarios sobre sus valores, motivaciones y relación con el fútbol. Los resultados muestranque los entusiastas son los aficionados más motivados y comprometidos con el fútbol al mismo tiempo que participan significativamente más de valores relacionados con el conservadurismo y la autopromoción que las otras tres categorías (espectadores, aficionados presenciales y aficionados virtuales. La clasificaciónpropuesta en base al tipo de contacto con el fútbol permite conceptualizar el fútbol como algo más que lo que ocurre en los estadios y abre las puertas a intervencionesdesde lo positivo para promover el fair play y la deportividad en los aficionados.

Transgenic rabbits as a model organism for production of human clotting factor VIII

International Nuclear Information System (INIS)

Vasicek, D.; Chrenek, P.; Makarevich, A.; Bauer, M.; Jurcik, R.; Suvegova, K.; Rafay, J.; Bulla, J.; Hetenyi, L.; Erickson, J.; Paleyanda, R.K.

2005-01-01

Human clotting factor VIII (hFVIII) is a very complex and large protein whose expression is difficult, as hFVIII requires extensive post-translational modification to be biologically active. This paper reports the generation of transgenic rabbits as a model species for testing the expression of hFVIII in the mammary gland. For micro-injection, a fusion gene construct was used, consisting of 2.5 kb murine whey acidic protein (mWAP) promoter, 7.2 kb cDNA of hFVIII, and 4.6 kb of 3' flanking sequences of the mWAP gene. from 130 micro-injected zygotes transferred into recipients, 30 offspring were delivered. The pups were screened for the transgene by PCR, using DNA isolated from the ear, and results were confirmed by Southern blot analysis. The transgene was identified in one female founder animal, and it was transmitted to the offspring in a Mendelian fashion, thus demonstrating stable integration of the gene construct into the germline of the transgenic rabbits. (author)

Analysis of the 4d7 (4f + 6p) and 4p54d9 configurations of Sn VII, Sb VIII and Te IX

International Nuclear Information System (INIS)

Azarov, V.I.; Joshi, Y.N.; Churilov, S.S.; Ryabtsev, A.N.

1994-01-01

The spectra of tin, antimony and tellerium were photographed in the 120-200 A region on 10.7 m and 3 m grazing incidence spectrographs using a triggered spark source. The 4d 8 -4d 7 (4f + 6p) + 4p 5 4d 9 transitions of Sn VII, Sb VIII and Te IX were investigated. In the Sn VII spectrum 109 new lines were classified in the 152-192 A region and 34 new levels were established, in the Sb VIII spectrum 78 new lines were classified in the 138-158 A region and 21 new levels were established, and in the Te IX 76 new lines were classified in the 121-139 A region and 21 new levels were established. Strong configuration interaction among the 4d 7 (np + mf), and 4p 5 4d 9 (n = 5, 6; m = 4, 5) configurations was observed. Least-squares-fitting (LSF) parametric calculations involving configuration interaction were carried out to interpret the observed spectra. (orig.)

Memórias e representações acerca do SUS para técnicos e auxiliares de enfermagem

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Caren Camargo Espírito Santo

2010-12-01

Full Text Available As memórias e representações dos SUS influenciam saberes e práticas profissionais. Assim, este estudo tem o objetivo de analisar as memórias e as representações de profissionais de enfermagem acerca do SUS. Trata-se de uma pesquisa qualitativa baseada nas Representações Sociais e desenvolvida com 26 profissionais de enfermagem de nível fundamental e médio. Os dados foram coletados em 2005 por entrevistas e analisados pelo software ALCESTE 4.7. Os resultados foram organizados em dois grupos: o bloco temático 1 que engloba a classe 1 (Imagens e definições do SUS e do INAMPS e a classe 4 (As transformações ocorridas no sistema de saúde; e o bloco temático 2, com a classe 2 (Representações e memórias da rede básica de saúde e classe 3 (As interrelações da equipe de enfermagem: o médico e os usuários no contexto do SUS. Conclui-se que ainda não está clara para os profissionais a condição de acesso aos serviços públicos de saúde sobrepondo o SUS ao sistema antigo de saúde, o INAMPS, e que as dificuldades encontradas pelos sujeitos nas questões concernentes ao acesso aos serviços de saúde, às relações interpessoais e às condições de trabalho apontam para o SUS como um sistema ainda em processo de implementação.

Los “Pirobos”: nómadas en el mercado del deseo

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Carlos Iván García Suárez

1999-04-01

Full Text Available El artículo intenta comprender el nomadismo de los tránsitos y devenires recurrentes de niños y jóvenes varones prostituidos, respecto de sus identidades sexual y social, de sus relaciones con el hábitat de la calle y con sus habitantes, y de sus localizaciones y desplazamientos estratégicos de mercado; se pregunta también por los recorridos vitales y espaciales de los clientes. Busca, en suma, revelar la racionalidad de la errancia que posibilita el encuentro de la oferta y la demanda en el mundo de la prostitución masculina, que harto nos dice sobre ajuste a las normas y puntos de fuga, sobre los márgenes por los que el deseo transita.“El niño que mantiene comercio con un hombre no comparte como la mujer los gozos del amor: mira con la frialdad de un hombre en ayunas al que está ebrio de amor”.Jenofonte, El banquete VIII, 21.

Pharmaceutical assistance within the SUS: the experience of students in Rural Internship from a Pharmacy Course

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Luciana Tarbes Mattana Saturnino

2009-12-01

Full Text Available The 2002 Brazilian Curricular Lines established a new curriculum for Pharmacy Programs, including amplified information about the Unified Health System (SUS. Following this, some Colleges have implemented a Rural Internship (RI discipline, as a way to promote: a adequate information on the SUS, and b students' interaction with pharmaceutical assistance. In this study we analyzed the perceptions of students enrolled in the Rural Internship program of the undergraduate Pharmacy Program at the Federal University of Minas Gerais. Eight students participated in this study and their perceptions and ideas were obtained by focus groups, both before and after the RI. This information was analyzed by content analysis. The students had a fragmented, distorted view on assistance, before as well as after taking the RI. Nevertheless, the RI provided students with a view of the professional realities and difficulties routinely faced by pharmacists in the public health system. The RI course of the Pharmacy Programs was viewed as an opportunity to improve the professional work within the SUS.As Diretrizes Curriculares de 2002 implantaram um novo currículo para o Curso de Farmácia, trazendo como propósito a aprendizagem para o Sistema Único de Saúde (SUS. Para atender a esta demanda, algumas Faculdades têm implantado a disciplina de Internato Rural (IR como forma de viabilizar o ensino para o SUS e a interação do aluno com a assistência farmacêutica. Este trabalho analisa a concepção de alunos do IR do Curso de Farmácia da Universidade Federal de Minas Gerais sobre a assistência farmacêutica e sobre a atividade do profissional farmacêutico no SUS. A coleta das informações foi realizada por meio da técnica do grupo focal antes e após o IR. Para a análise dos discursos foi utilizada a técnica da análise de conteúdo. Participaram do estudo oito estudantes. Observou-se que os alunos apresentavam uma visão fragmentada sobre a assist

SusG: A Unique Cell-Membrane-Associated [alpha]-Amylase from a Prominent Human Gut Symbiont Targets Complex Starch Molecules

Energy Technology Data Exchange (ETDEWEB)

Koropatkin, Nicole M.; Smith, Thomas J. (Danforth)

2010-09-21

SusG is an {alpha}-amylase and part of a large protein complex on the outer surface of the bacterial cell and plays a major role in carbohydrate acquisition by the animal gut microbiota. Presented here, the atomic structure of SusG has an unusual extended, bilobed structure composed of amylase at one end and an unprecedented internal carbohydrate-binding motif at the other. Structural studies further demonstrate that the carbohydrate-binding motif binds maltooligosaccharide distal to, and on the opposite side of, the amylase catalytic site. SusG has an additional starch-binding site on the amylase domain immediately adjacent to the active cleft. Mutagenesis analysis demonstrates that these two additional starch-binding sites appear to play a role in catabolism of insoluble starch. However, elimination of these sites has only a limited effect, suggesting that they may have a more important role in product exchange with other Sus components.

Diagnostic accuracy study of a factor VIII ELISA for detection of factor VIII antibodies in congenital and acquired haemophilia A.

Science.gov (United States)

Batty, Paul; Moore, Gary W; Platton, Sean; Maloney, James C; Palmer, Ben; Bowles, Louise; Pasi, K John; Rangarajan, Savita; Hart, Daniel P

2015-10-01

Antibody formation to factor VIII (FVIII) remains the greatest clinical and diagnostic challenge to the haemophilia-treating physician. Current guidance for testing for inhibitory FVIII antibodies (inhibitors) recommends the functional Nijmegen-Bethesda assay (NBA). A FVIII ELISA offers a complementary, immunological approach for FVIII antibody testing. It was the aim of this study to retrospectively evaluate the performance of a FVIII ELISA (index) for detection of FVIII antibodies, compared with the NBA (reference). All samples sent for routine FVIII antibody testing at two haemophilia Comprehensive Care Centres, were tested in parallel using the NBA and a solid-phase, indirect FVIII ELISA kit (Immucor). A total of 497 samples from 239 patients (severe haemophilia A=140, non-severe haemophilia A=85, acquired haemophilia A=14) were available for analysis. Sixty-three samples tested positive by the NBA (prevalence 12.7%, 95% confidence interval [CI], 9.9-15.9 %), with a median inhibitor titre of 1.2 BU/ml (range 0.7-978.0). The FVIII ELISA demonstrated a specificity of 94.0% (95%CI, 91.3-96.0), sensitivity of 77.8% (95%CI, 65.5-87.3), negative predictive value of 96.7% (95%CI, 94.5-98.2), positive predictive value 65.3% (95%CI, 53.5-76.0), negative likelihood ratio 0.2 (95%CI, 0.1-0.4), positive likelihood ratio 13.0 (95%CI, 8.7-19.3) and a diagnostic odds ratio of 54.9 (95%CI, 27.0-112.0). Strong positive correlation (r=0.77, pNBA (log adjusted) and FVIII ELISA optical density. In conclusion, FVIII ELISA offers a simple, specific, surveillance method enabling batch testing of non-urgent samples for the presence of FVIII antibodies.

Realidades de mujeres que promueven organización y participación desde sus territorios, en una sociedad que intenta terminar con el conflicto armado

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Martha Elena Saboya Ramírez

2017-08-01

Full Text Available Hoy en día en Colombia, mujeres residentes en María la Baja, municipio del departamento de Bolívar, persisten en sus procesos organizativos para atender al desarrollo de objetivos reivindicatorios con ocasión de las consecuencias y secuelas generadas por el conflicto armado. Sus interacciones, gestiones y movilizaciones ante el Estado, centran su atención en la búsqueda de la restauración de sus derechos y los de sus familias debido al desplazamiento. Pretenden lograr el retorno a sus tierras, contar con vivienda segura y servicios públicos, trabajar de manera digna y honrada, como siempre fue y ha sido su aspiración. En estos procesos identifican y vivencias nuevas formas de entender y comprender los fenómenos sociales, en consecuencia direccionan sus apuestas sociales e introducen cambios en sus entornos familiares y en su diario vivir.

Declive de la función paterna y sus efectos en las dificultades de aprendizaje.

OpenAIRE

Alvarado Hermida, Carola Yolanda

2015-01-01

El presente estudio intenta lograr un entendimiento desde la perspectiva psicoanalítica y sus conceptos fundamentales, de las denominadas dificultades de aprendizaje, abordado desde los cambios sociales actuales específicamente el declive de la función paterna y sus efectos en el proceso de aprendizaje. Para esto iniciaremos en el capítulo I revisando el origen del concepto teórico de la función paterna desde el psicoanálisis en Freud y Lacan. Luego, en el capítulo II, realizaremos una ...

La Asociación Latinoamericana de Sociología: una historia de sus primeros congresos

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Blanco Alejandro

2005-01-01

Full Text Available El examen de las asociaciones nacionales y regionales de sociología de América Latina, de su estructura y composición como de sus transformaciones es, todavía hoy, una asignatura pendiente en la historia de la disciplina. Este trabajo reconstruye la historia de los primeros años de la Asociación Latinoamericana de Sociología, intentando caracterizar su contexto de emergencia, sus principales rasgos y su papel en la formación de la sociología de la región.

THE POLYMORPHISM OF THE SUS4 SUCROSE SYNTHASE DOMAIN SEQUENCES IN RUSSIAN, BELORUSSIAN AND KAZAKH POTATO CULTIVARS

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M. A. Slugina

2016-01-01

Full Text Available The potato is one of the main strategic crops in the Russian Federation, Belarus and Kazakhstan. Currently, we have achieved significant advances in the understanding of metabolic mechanism of carbohydrate and interconversion «sucrose – starch» in potato tubers. Sucrose synthase (Sus is a key enzyme in the breakdown of sucrose. Sucrose synthase (Sus is catalyzing a reversible reaction of conversion sucrose and UDP into fructose and UDP-glucose. The identification and subsequent characterization of the genes encoding plant sucrose synthase is the first step towards understanding their physiological roles and metabolic mechanism involved in carbohydrate accumulation in potato tubers. In the present work the nucleotide and amino acid polymorphism of the Sus4 gene fragments containing sequences of the sucrose synthase domain were analyzed. Sus4 gene fragments (intron III – exon VI in 9 potato cultivars of Russian, Kazakh and Belarusian breeding were analyzed. The polymorphism of the Sus4 sucrose synthase domain sequences was first examined. The length of analyzed fragment varied from 977 b.p. (cultivars Favorit, Karasaiskii, Miras to 1013 b.p. (cultivars Zorochka, Manifest, Elisaveta, Bashkirskii. It was demonstrated that the examined sequences contained point mutations, as well as insertions and deletions. The common polymorphism level was 5.82%. It was shown that the examined sequences contained 58 SNPs and 4 indels. The most variable were introns IV (12.4% and V (9.18%. The most variable was exon IV. 7 allelic variants were detected. 6 different amino acid sequences specific to different varieties were also identified.

LAS CREENCIAS SOBRE OBESIDAD DE NIÑOS Y NIÑAS EN EDAD ESCOLAR Y LAS DE SUS PROGENITORES

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Hilda Patricia Núñez Rivas

2013-01-01

Full Text Available El propósito de este artículo es evidenciar, mediante el método etnográfico, las creencias sobre la obesidad de niños y niñas en edad escolar y las de sus progenitores, pertenecientes a una escuela urbana y pública de San José, Costa Rica. Los resultados apuntan hacia las creencias negativas de la niñez respecto a sus pares con obesidad y sus implicaciones psicosociales y afectivas. En relación con los progenitores se señalan las causas y estrategias de control, las implicaciones de la obesidad, referente a enfermedades físicas y emocionales; el papel del hogar y de la escuela en su prevención. Se concluye que los niños y las niñas creen que la obesidad no es una enfermedad, sino u na expresión fenotípica, a la cual le dan grado de relatividad o de escala y la consideran no deseable, resultado que concuerda con la de sus progenitores. Las niñas participantes con obesidad expresaron sus posiciones de defensa y molestia, en relación con experiencias burlescas. Al contrario de sus hijos e hijas, la mayoría de los progenitores sí cree que la obesidad es una enfermedad o un problema de salud o de estética. Además, estiman que esta se controla utilizando una dieta saludable y equilibrada, dando consejos sobre las consecuencias físicas y emocionales de la obesidad y ofreciendo modelos de personas saludables. Por lo tanto, los progenitores y el personal docente creen que la escuela poco puede hacer respecto a la alimentación saludable del alumnado, pues el hogar es el lugar que tiene un papel primordial.

Actitud del estudiante de ingeniería hacia sus errores en el aprendizaje de la matemática

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Lissette Franchi Boscán

2011-09-01

Full Text Available Bajo cualquier esquema de enseñanza-aprendizaje de la matemática, cuando al alumno se le señalan errores en su trabajo, puede, en general, adoptar tres tipos de actitud: una actitud negativa, bajo la cual el alumno considera que sus errores son sencillamente un síntoma de su fracaso; una actitud neutra o indiferente ante sus errores; o una actitud positiva, considerándolos como un medio para aprender y planteándose como reto el superarlos. Este artículo muestra una investigación que abordó el estudio de actitudes vinculadas al proceso de aprendizaje de la matemática. Su objetivo fue describir la actitud que el estudiante de ingeniería de la Uni- versidad del Zulia exhibe frente a sus errores cuando aprende matemática. La sus tentación teórica se baso en Brousseau (2001, Briñol et al. (2007 y los autores Pallí y Martínez (2004. Se utilizó una escala AEAM (Actitud hacia el Error del Alumno de Matemática, tipo Likert con 6 alternativas de respuesta que consta de 36 ítems, en su segunda versión, actualizada por los autores. El instrumento fue validado mediante juicio de expertos y se determinó que era de alta confiabilidad, con un alpha de Cronbach de 0.9073. Se concluyó que los participantes, en su mayoría, mostraron una actitud moderadamente positiva hacia sus errores, que al no estar ubicada en el extremo positivo deseable refleja una actitud débil que no garantiza una conducta adecuada hacia los errores, pero que sin embargo es sus ceptible de ser mejorada hacia una actitud francamente positiva.

Las redes del narcotráfico y sus interacciones: un modelo teórico

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Leonardo Raffo López

2015-06-01

Full Text Available En este artículo se propone un modelo teórico que ayuda a entender el funcionamiento de las redes de defensa y corrupción del narcotráfico. Con base en las teorías de juegos y de redes se analizan las interacciones estratégicas entre los narcotraficantes y sus agentes. Se prueba que la densidad de las redes es un determinante fundamental de la probabilidad de supervivencia de los narcotraficantes y de los salarios que pagan a sus hombres; y que la eficacia de las políticas de represión de la oferta depende de la densidad de las redes.

La política nacional del Ecuador para la Antártica y sus mecanismos de aplicación

OpenAIRE

Moreano, H.R.

1989-01-01

La Primera Expedición Ecuatoriana a la Antártica condujo una serie de observaciones científicas en el Paso Drake y Estrecho Bransfield durante el verano austral 1987-88, cuyos resultados se prublicaron en el "Acta Antártica Ecuatoriana" en marzo 89, de esta manera el Ecuador hacía realidad sus intereses en la Antártica. Se propone un concepto de la Política Nacional para la Antártica, basada en los lineamientos y consideraciones del Tratado Antártico y sus convenciones, así como también sus m...

Toxicity of herbal medicines with interest to SUS: a review

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Ciciane Pereira Marten Fernandes

2016-11-01

Full Text Available Abstract: In Brazil, ever since colonization plants have been used as natural products; thus, the National Health Surveillance Agency has been establishing rules for herbal medicine regulation; in this light, 71 plant species were chosen and empirically used in the country to investigate their medicinal properties. Currently, 12 of these 71 plants have been approved to be used in SUS (Public Health System, the remaining species still need further research. Thusly, this review aimed to seek information from toxicological studies on the plants that have not yet been officially approved, to stimulate new research in the field, promoting an economical and functional impact. In order to obtain the information, the keywords plant name + toxicity and/or toxicological studies were searched in the most prominent databases, both in English and in Portuguese. The ten plants with the most references were included in this review. Among the ten plants assessed, three have all the required studies required by the National Health Surveillance Agency, two of which we recommend the immediate adoption by SUS. In general, three plants have a determined LD50, nine have reproductive toxicity data, and five have not yet shown any sign of toxicity.

Separation method for ions of elements of the III., IV., VI. and VIII. groups of periodical system

International Nuclear Information System (INIS)

Marhol, M.

1973-01-01

The method is presented of separating the ions of the elements of the periodic system groups III, IV, and VIII by ion exchangers. The ions are complex-bonded to a new type of ion exchanger consisting of the polycondensates of phenol with aldehydes or ketones and containing an atom of phosphorus, arsenic or antimony with an atom of sulphur or oxygen in a complex bond. The polymers of compounds containing a double bond, e.g., of butadiene, polyvinyl alcohol, polyethylene, polypropylene, and the compounds of styrene with fural may also be used for this purpose. The method is demonstrated on a case of uranium and heavy metal concentration and the separation thereof from waste waters. (L.K.)

Spectra of the W VIII isoelectronic sequence: III. Re IX

International Nuclear Information System (INIS)

Ryabtsev, A N; Kononov, E Ya; Kildiyarova, R R; Tchang-Brillet, W-Ü L; Wyart, J-F; Champion, N; Blaess, C

2015-01-01

Rhenium spectra excited in vacuum spark sources of different setups and electric circuits were recorded on two high resolution vacuum spectrographs: a 10 m normal incidence spectrograph with a 3600 l mm −1 grating in the Meudon Observatory and a 3 m grazing incidence spectrograph with a 3600 l mm −1 grating in the Institute of Spectroscopy in Troitsk. A total of 112 lines in the region 146–244 Å were identified as transitions from the interacting excited even configurations 4f 12 5s 2 5p 6 5d + 4f 13 5s 2 5p 5 (5d + 6s) + 4f 14 5s 2 5p 4 (5d + 6s) to the low-lying odd configurations 4f 13 5s 2 5p 6 and 4f 14 5s 2 5p 5 . A change of the ground configuration from 4f 13 5s 2 5p 6 to 4f 14 5s 2 5p 5 in a comparison with the previous spectra of the isoelectronic sequence Hf VI–W VIII was observed. Fine structure splittings and relative positions of the odd terms were established, and 83 levels of the excited even configurations were found. (paper)

Grotrian diagrams of highly ionized iron Fe(VIII)-Fe(XXVI)

International Nuclear Information System (INIS)

Mori, Kazuo; Otsuka, Masamoto; Kato, Takako.

1977-08-01

Energy levels and Grotrian diagrams of Fe(VIII) to Fe(XXVI) are presented. This report summarized the data published recently up to 1976, and the wavelength tables compiled were converted to the Grotrian diagrams. The diagrams showing transition from one energy level to another are called Grotrian diagrams. Typical examples of the diagrams are found in the book by Bashkin et al. In the present diagrams, all lines are drawn in parallel, and connected to the extended lines from lower levels. As the results, locally dense packing of lines and figures is avoided. The ordinate of the diagrams indicates level energy, and the J values are shown on the left side of the levels. The wavelength values in angstrom unit are written in parallel with the vertical transition lines. This vertical lines show the resonance transition having absorption oscillator strength f larger than 0.1. The present diagrams are the combination of the tables of wavelength and energy level. Accordingly, the desired wavelength and level energy are easily found. The figures of wavelength are lined up in various groups, so that the characteristics of the transition can be discriminated at a glance. Wavelength and level energy have been mostly derived from experimental spectra in laboratory or solar plasma, except a few by Fawcett's prediction. (Kato, T.)

Patient preference and ease of use for different coagulation factor VIII reconstitution device scenarios: a cross-sectional survey in five European countries

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Cimino E

2014-12-01

Full Text Available Ernesto Cimino,1 Silvia Linari,2 Mara Malerba,3 Susan Halimeh,4 Francesca Biondo,5 Martina Westfeld5 1Dipartimento Medicina Clinica e Sperimentale, Universita’ degli Studi di Napoli Federico II, Naples, Italy; 2Agenzia per l’ Emofilia, AOU Careggi di Firenze, Florence, Italy; 3Fondazione Cà Granda Ospedale Maggiore Policlinico, Centro Emofilia e Trombosi “A Bianchi Bonomi”, Milan, Italy; 4CRC Coagulation Research Centre GmbH, Duisburg, Germany; 5Pfizer Italia, Rome, Italy Introduction: Hemophilia A treatment involves replacing the deficient coagulation factor VIII. This process may involve multiple steps that might create a barrier to adherence. A new dual-chamber syringe (DCS; FuseNGo® was recently introduced with the aim of simplifying reconstitution. Aim: This study aimed to identify factors associated with adult patients’ preferences for different coagulation factor VIII reconstitution systems and to test ease of use and patient preference for the DCS. Methods: A cross-sectional survey of adults with hemophilia A in five European countries was conducted; a subset of subjects also participated in a practical testing session of the DCS. Results: Among the 299 survey participants, the device scenario requiring the least equipment and reconstitution steps (the DCS received a median preference rating of 71 out of 100 (0 being “the least desirable” and 100 “the most desirable” rating. This was significantly higher than the other scenarios (the next highest achieved a median of 50 points; P<0.001. Participants would be more likely to use this device prophylactically (P<0.001. Among the 98 participants who tested the DCS, 57% preferred this device over their current device, 26% preferred their current device, and 17% had no preference. The DCS was rated as easier to use than current treatment devices (median score 9/10 versus 7/10 for current treatment, P=0.001. Conclusion: The survey indicates that the prefilled DCS, Fuse

[The beneficial effect of mineral waters of Fiuggi on Pope Bonifacio VIII and Michelangelo: two prominent calculous patients].

Science.gov (United States)

Androutsos, Georges

2005-09-01

Going back to the dawn of time, we deal with two historical figures, that of Pope Bonifacio VIII, and that of the hierophant of art, Michelangelo Buonarroti. The texts and the codes of the British Museum (Department of Manuscripts), of the Biblioteca Medica Laurenziana (Archivio Buonarroti) of Florence, and the Biblioteca Apostolica of Vatican, convincing detalled evidence that both figures were urological patients. It concerns two clinical cases with especially pertain to the history of lithiasis of urinary tract. Even though, both of them--the first with nephrolithiasis or gravel, and the second with a bladder stone--were historically bound with the well-known cures of Fiuggi in Italy.

Computed tomography in Brazil: frequency and pattern of usage among inpatients of the Unified Health System (SUS)

International Nuclear Information System (INIS)

Dovales, Ana Cristina M.; Souza, Andressa A. de; Veiga, Lene H.S.

2015-01-01

This paper shows the frequency, pattern and trend of computed tomography use in inpatients of the Brazilian public health care system (SUS), from 2008 to 2011. Data were extracted from an Internet database provided by SUS. Head/neck examinations were the most frequent type of CT over the study period. The use of CT increased over time, with the greatest increase being observed for CT of extremities. (author)

Metodologia de construção de um painel de indicadores para o monitoramento e a avaliação da gestão do SUS Methodology for construction of a panel of indicators for monitoring and evaluation of unified health system (SUS management

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Edson Mamoru Tamaki

2012-04-01

Full Text Available Este estudo teve como objetivo desenvolver uma metodologia de construção de um Painel de Monitoramento e Avaliação da Gestão do Sistema Único de Saúde (SUS. O processo participativo utilizado e a sistematização realizada permitiram identificar uma estratégia efetiva para a construção de instrumentos de gestão em parceria entre pesquisadores, instituições acadêmicas e gestores do SUS. A sistematização final do Painel selecionou indicadores da gestão do SUS em termos de Demandas, Insumos, Processos, Produtos e Resultados de forma a disponibilizar um instrumento simples, ágil e útil para a avaliação em qualquer instância de gestão e mais transparente e de mais fácil comunicação com todos os interessados na tomada de decisão. Tomar a gestão do SUS como objeto destes processos e práticas em seus aspectos normativos possibilitou o diálogo entre teorias sistêmicas e aquelas que consideram a centralidade do ator social no processo de tomada de decisão.This study sought to develop methodology for the construction of a Panel for the Monitoring and Evaluation of Management of the Unified Health System (SUS. The participative process used in addition to the systematization conducted made it possible to identify an effective strategy for building management tools in partnership with researchers, academic institutions and managers of the SUS. The final systematization of the Panel selected indicators for the management of the SUS in terms of Demand, Inputs, Processes, Outputs and Outcomes in order to provide a simple, versatile and useful tool for evaluation at any level of management and more transparent and easier communication with all stakeholders in decision-making. Taking the management of the SUS as the scope of these processes and practices in all normative aspects enabled dialog between systemic theories and those which consider the centrality of the social actor in the decision-making process.

Regionalização e novos rumos para o SUS: a experiência de um colegiado regional Regionalization and new courses to SUS: the experience of a regional college

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Emerson Assis

2009-03-01

Full Text Available Em que pese todos os avanços no Sistema Único de Saúde (SUS desde a sua implantação, são também notórias as suas fragilidades e seus limites. Um deles, não obstante a diretriz constitucional de regionalização, é que até recentemente não havia uma política concreta de estímulo de integração entre os municípios e, consequentemente, de regiões de saúde, tão necessárias à garantia da integralidade da atenção. Nos últimos três anos, entretanto, o Ministério da Saúde, com a implementação do Pacto pela Saúde, na sua dimensão da gestão, iniciou esse processo, que tem se mostrado promissor para o desenvolvimento e crescimento do SUS nacional. Este trabalho apresenta a experiência positiva de implantação de um Colegiado Regional no Estado de São Paulo, na região de Campinas, através da qual gestores e técnicos das secretarias de saúde estão se tornando sujeitos mais "empoderados" da construção da Saúde na região.Despite all the advances that have occurred in Sistema Único de Saúde (SUS - National Health System since its implementation, its weaknesses and limits are also remarkable. One of them, in spite of the constitutional guideline for regionalization, is that, until recently, there had been no concrete policy to stimulate integration between municipalities and, consequently, between health regions, which are necessary to ensure integral care. In the last three years, however, the Ministry of Health, with the implementation of the Health Pact in its management dimension, started this process, which has been promising to the development and growth of the national SUS. This study presents the positive experience of implementation of a Regional College in the State of São Paulo, in the region of Campinas, through which managers and technicians of the health departments are becoming empowered subjects of the construction of Health in the region.

LA INSEGURIDAD LABORAL Y SUS CONSECUENCIAS EN UN CONTEXTO DE CRISIS ECONÓMICA

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Beatriz Sora

2014-01-01

Full Text Available La inseguridad laboral se ha convertido en la actualidad en una de las fuentes de estrés más significativas para muchos trabajadores, siendo especialmente grave en España por las elevadas tasas de desempleo en este periodo de crisis económica. Una prolífera investigación se ha desarrollado al respecto en un intento por alcanzar un conocimiento más completo de este fenómeno. El Instituto de Psicología de los Recursos Humanos, Desarrollo Organizacional y Calidad de Vida Laboral (IDOCAL ha contribuido a esta investigación en los últimos años en varias de sus facetas más significativas. En el ámbito de sus factores determinantes se ha identificado un papel significativo de la antigüedad laboral, la empleabilidad en el mercado laboral, el subempleo, y la autoeficacia laboral. Además se han realizado hallazgos de interés en relación con la diversidad de los tipos de contrato, la inseguridad laboral y sus efectos en los trabajadores. Son de especial interés los estudios que analizan el papel interviniente de distintas variables. En este contexto, nuestros estudios han puesto de manifiesto la relevancia de variables como la justicia organizacional, el clima de justicia organizacional, el apoyo organizacional, la empleabilidad, la dependencia laboral y el distanciamiento psicológico a la hora de predecir la variabilidad en la inseguridad laboral. Por último, las aportaciones del IDOCAL han sido especialmente relevantes al plantear el análisis de la inseguridad laboral como fenómeno colectivo y mostrar cómo la experiencia colectiva de la inseguridad tenía repercusiones sobre el bienestar de los trabajadores más allá de las producidas por sus percepciones individuales. En base a esta investigación se han propuesto en el presente artículo una serie de implicaciones para la práctica profesional.

Helminth parasites of wild boar, Sus scrofa, in Iran.

Science.gov (United States)

Eslami, A; Farsad-Hamdi, S

1992-04-01

Fifty-seven wild boars (Sus scrofa) from protected regions of Iran were examined for helminths. Sixteen species of helminths were collected; there were ten nematodes, one acanthocephalan, two trematodes and three larval cestodes. New host and distribution records were established for all helminths except of Taenia solium cysticerci. Wild boar shared nine of these helminths with domestic pigs, six with ruminants and three with human beings in Iran. Metastrongylus pudendotectus and M. salmi are reported for the first time from Iran.

EL MAESTRO ORLANDO FALS BORDA SUS IDEAS EDUCATIVAS Y SOCIALES PARA EL CAMBIO EN LA SOCIEDAD COLOMBIANA

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Javier Ocampo López

2009-01-01

Full Text Available Este trabajo de investigación de HISULA en la serie de Educadores Latinoamericanos tiene por objeto el estudio de las ideas educativas y la metodología científica de la Investigación-Acción Participativa del educador Dr. Orlando Fals Borda, uno de los grandes ideólogos de la educación universitaria en Colombia. Se preocupa por el análisis de sus principales obras relacionadas con el estudio sociológico de los campesinos de los Andes y el Hombre y la Tierra en la región cundiboyacense del Altiplano Andino. Este ilustre educador barranquillero hizo sus trabajos de investigación sociológica del pueblo colombiano y defendió el papel de la educación en el cambio social. Con su metodología de la investigación-acción participativa señaló los nuevos rumbos de la educación colombiana centrada en el alumno y en la filosofía del "aprender haciendo". En sus actividades docentes formó una generación de sociólogos dedicados a la investigación social en una época de crisis y de cambios. Por ello su acción se realizó en la Facultad de Sociología de la Universidad Nacional y en sus investigaciones científicas y educativas, destacando su metodología de "La investigación-Acción Participativa". Su actuación fue definitiva como ideólogo de la Constitución Nacional de 1991, en la cual se plasmaron algunas de sus ideas.

The role of genotype on classification grades of beef carcasses produced under mexican tropical conditions

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José Manuel Zorrilla-Ríos

2015-01-01

Full Text Available El presente estudio identificó la distribución de 22,850 canales de bovino de diferentes genotipos. Éstos, en función del juzgamiento visual del tamaño de la giba (grande, representativa de un genotipo Bos indicus; mediana, genotipo producto de la cruza entre B. taurus y B. indicus y pequeña, considerada como genotipo B. taurus en los grados de clasificación obtenidos bajo la norma mexicana NMX-FF-078-SCFI-2002, en el rastro Tipo Inspección Federal No. 51 de La Unión, Tabasco (México. Se determinó el grado de asociación y la proporción de canales, juzgados por el tamaño de su giba; y el criterio de clasificación de la canal, por el procedimiento analítico de Chi-Cuadrada. Cincuenta y cuatro por ciento de las canales correspondieron al tipo de giba grande (genotipo B. indicus, 35% al de pequeña (genotipo B. taurus y el 10.70% al de mediana (genotipo producto de la cruza entre B. taurus y B. indicus. En los genotipos B. taurus y cruza se concentró un mayor número de canales con clasificación de selecta (P<0.0001; 17.90 y 18.50%, respectivamente y estándar (55.20 y 60.10%, respectivamente que el genotipo B. indicus (10.10% para canales selectas y 39.30% de estándar. El genotipo B. indicus concentró un mayor número de canales de grado comercial (36.20% y fuera de clasificación (14.40% (P<0.0001. Los tres genotipos de bovinos considerados (B. indicus, B. taurus y Cruzas dieron lugar a canales clasificadas como selectas, sugiriendo que el genotipo no sea un factor de sesgo en la norma de clasificación de canales de bovino mexicano NMX-FF-078-SCFI-2002.

Liquid-liquid extraction and separation of VIII group elements, especially ruthenium, by synergic combinations or aromatic polyimines and micellar cationic exchangers

International Nuclear Information System (INIS)

Vitart, X.

1991-01-01

This thesis aims to characterize and to quantify the chemical equilibria involved in d-elements liquid-liquid extraction systems, especially elements belonging to the VIII group (Fe, Ni, Co, Ru, Rh, Pd, Pt). These systems are composed of synergic combination of aromatic polyimines and micellar cationic exchangers. Substitutions are first performed in aqueous acidic media by aromatic polyimines; then extractions are operated using micellic canionic exchangers. Chemical equilibria, selectivity effects, especially those due to ion-pair formations, kinetics, extractant behaviour are analysed and quantified [fr

El desarrollo psicomotor y sus alteraciones: entre lo normal y lo patológico

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Agustina Vericat

2013-10-01

Full Text Available El siguiente artículo discute aspectos propios del desarrollo psicomotor (DPM y sus alteraciones, con especial énfasis en el retraso psicomotor. Se hace referencia a las clasificaciones diagnósticas para los problemas del desarrollo como el DSMIV y el CIE 10, y se analizan sus ventajas y desventajas. También se problematiza el concepto de normalidad en tanto sinónimo de promedio estadístico en el contexto de los problemas del DPM, para considerar su dinámica y variabilidad, evitando la oposición normalidad/patología, y valorando aspectos como el sociocultural que permiten repensar la universalidad y la relatividad del DPM.

Formation of ultra-fine grained SUS316L steels by ball-milling and their mechanical properties after neutron irradiation

International Nuclear Information System (INIS)

Zheng, Y.J.; Yamasaki, T.; Fukami, T.; Terasawa, M.; Mitamura, T.

2003-01-01

In order to overcome the irradiation embrittlement in austenitic stainless steels, ultra-fine grained SUS316L steels with very fine TiC particles have been developed. The SUS316L-TiC nanocomposite powders having 1.0 to 2.0 mass% TiC were prepared by ball-milling SUS316L-TiC powder mixtures for 125 h in an argon gas atmosphere. The milled powders were consolidated by hot isostatic pressing (HIP) under a pressure of 200 MPa at temperatures between 700 and 1000 C, and the bulk materials with grain sizes between 100 and 400 nm have been produced. The possibility of using fine-grained TiC particles to pin grain boundaries and thereby maintain the ultra-fine grained structures has been discussed. In order to clarify the effects of the neutron irradiation on mechanical properties of the ultra-fine grained SUS316L steels, Vickers microhardness measurements were performed before and after the irradiation of 1.14 x 10 23 n/m 2 and 1.14 x 10 24 n/m 2 . The hardness increased with increasing the dose of the irradiation. However, these increasing rates of the ultra-fine grained steels were much smaller than those of the coarse-grained SUS316L steels having grain sizes between 13 and 50 μm. (orig.)

Microstructure and mechanical properties of annealed SUS 304H austenitic stainless steel with copper

Energy Technology Data Exchange (ETDEWEB)

Sen, Indrani [Department of Materials Engineering, Indian Institute of Science, Bangalore 560012 (India); Amankwah, E. [Department of Materials Engineering, Indian Institute of Science, Bangalore 560012 (India); Department of Materials Science, African University of Science and Technology, Abuja (Nigeria); Kumar, N.S. [Department of Materials Engineering, Indian Institute of Science, Bangalore 560012 (India); Fleury, E. [Center for High Temperature Energy Materials, Korea Institute of Science and Technology, Seoul 136-791 (Korea, Republic of); Oh-ishi, K.; Hono, K. [National Institute for Materials Science, 1-2-1 Sengen, Tsukuba 305-0047 (Japan); Ramamurty, U., E-mail: ramu@materials.iisc.ernet.in [Department of Materials Engineering, Indian Institute of Science, Bangalore 560012 (India)

2011-05-25

Research highlights: {yields} SUS 304H austenitic stainless steel containing 3 wt.% Cu was annealed at 700 deg. C for up to 100 h. {yields} Microstructure and mechanical properties of annealed alloys are examined. {yields} Nano-sized Cu-rich precipitation upon annealing. {yields} Strength of the alloy remains invariant with annealing whereas ductility improves. {yields} Fatigue crack growth threshold of 3 wt.% Cu added alloy increases with annealing. - Abstract: An experimental investigation into the effect of Cu on the mechanical properties of 0 and 3 wt.% Cu added SUS 304H austenitic stainless steel upon annealing at 700 deg. C for up to 100 h was conducted. Optical microscopy reveals grain coarsening in both the alloys upon annealing. Observations by transmission electron microscopy revealed the precipitation of nanometer-sized spherical Cu particles distributed within the austenitic grains and the presence of carbides at the dislocations. Both the yield and ultimate tensile strengths of the alloys were found to remain invariant with annealing. Tensile ductility and the threshold stress intensity factor range for fatigue crack growth for 3 wt.% Cu added alloy increase with annealing. These are attributed to the grain coarsening with annealing. In all, the addition of Cu to SUS 304H does not affect the mechanical performance adversely while improving creep resistance.

Evaluation of Neutron Reactions on Iron Isotopes for CIELO and ENDF/B-VIII.0

Science.gov (United States)

Herman, M.; Trkov, A.; Capote, R.; Nobre, G. P. A.; Brown, D. A.; Arcilla, R.; Danon, Y.; Plompen, A.; Mughabghab, S. F.; Jing, Q.; Zhigang, G.; Tingjin, L.; Hanlin, L.; Xichao, R.; Leal, L.; Carlson, B. V.; Kawano, T.; Sin, M.; Simakov, S. P.; Guber, K.

2018-02-01

A new suite of evaluations for 54,56,57,58Fe has been developed in the framework of the CIELO international collaboration. New resolved resonance ranges were evaluated for 54Fe and 57Fe, while modifications were applied to resonances in 56Fe. The low energy part of the 56Fe file is almost totally based on measurements. At higher energies in 56Fe and in the whole fast neutron range for minor isotopes the evaluation consists of model predictions carefully adjusted to available experimental data. We also make use of the high quality and well experimentally-constrained dosimetry evaluations from the IRDFF library. Special attention was dedicated to the elastic angular distributions, which were found to affect results of the integral benchmarking. The new set of iron evaluations was developed in concert with other CIELO evaluations and they were tested together in the integral experiments before being adopted for the ENDF/B-VIII.0 library.

The Osteometrical Characteristics of Mandibles of Sus Scrofa Population in the Czech Republic (České Budějovice) in Comparison with Sus Scrofa Population in Chile and Japan

Czech Academy of Sciences Publication Activity Database

Dvořáková-Líšková, Zuzana; Hanzal, V.; Janiszewski, P.

3/13, č. 3 (2007), s. 42-51 ISSN 0909-6396 R&D Projects: GA MŠk(CZ) 1P05OC060 Institutional research plan: CEZ:AV0Z60870520 Keywords : Sus Scrofa * osteometry Subject RIV: EG - Zoology Impact factor: 0.894, year: 2007

The transitions 4p-5s in Y VI, Zr VII, Nb VIII and Mo IX

International Nuclear Information System (INIS)

Chaghtai, M.S.Z.; Rahimullah, K.; Khatoon, S.

1976-01-01

With the help of the spectra recorded in the Physics Department of Lund University, Y VI, Zr VII, Nb VIII and Mo IX are freshly analysed. The five 4s 2 4p 4 ground levels and the ten 4s 2 4p 3 5s levels of previous analyses are confirmed in the first three spectra, except for revising in Y VI the 4p 4 1 S 0 and 4p 3 5s( 4 Ssub(3/2)) 2 levels and interchanging 5s( 2 Dsub(3/2)) 1 with 5s( 2 Dsub(3/2)) 2 . All level values are improved due to the new measurements. A new analysis of Mo IX establishing all the 4p 4 and 4p 3 5s levels is being reported. (Auth.)

Los padres como observadores de la calidad de vida de sus hijos implantados cocleares

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Silvia Andrea BORKOSKI-BARREIRO

2017-06-01

Full Text Available Introducción y objetivo: El concepto de calidad de vida ha comenzado a utilizarse cada vez más en el campo de las evaluaciones en salud. Se ha empezado a investigar los efectos de la implantación a nivel del desarrollo social y emocional del niño. El objetivo es examinar los resultados de la salud relacionados con la calidad de vida en niños sordos implantados cocleares de entre 11 y 12 años de edad y sus padres. Método: Estudio observacional, descriptivo transversal en 24 niños prelocutivos implantados unilaterales o bilaterales sucesivos de 11 y 12 años de edad y sus padres. Utilizando el cuestionario de calidad de vida pediátrica PedsQL™ (Versión 4.0, español para España, para medir la salud relacionados con la calidad de vida, completado de forma independiente por niños y padres respectivamente. Resultados: Mediante la T-Student los resultados de niños y padres en las diferentes escalas evaluadas observamos que en las escalas de funcionamiento emocional y académica es donde se obtienen resultados estadísticamente significativos (p <0,05. Al comparar el resultado total del cuestionario con las diferentes escalas evaluadas, en todas ellas se obtienen resultados estadísticamente significativos (p <0,05. Discusión: Probado el éxito del implante coclear en las áreas del habla y del lenguaje, esto nos lleva actualmente a preguntas más allá de estas áreas; el rendimiento en el hogar, en la escuela y en diferentes contextos sociales. Pocos estudios exploran a través de entrevistas o cuestionarios las expectativas de los padres y la percepción de la calidad de vida de sus hijos usuarios de implantes coclear. Conclusiones: Los resultados del estudio muestran que los niños disfrutan de los beneficios del uso de su implante coclear. Ellos reportan beneficios en todas las áreas estudiadas (física, emocional, social y académica. Los padres son periodistas válidos sobre el estado de la calidad de vida global de sus hijos ya

Las familias homoparentales y sus redes de apoyo social

OpenAIRE

González Rodríguez, María del Mar; Sánchez, M. Ángeles

2003-01-01

Este trabajo tiene como objetivo avanzar en conocimiento con respecto a las familias homoparentales, estudiando sus redes de apoyo social, aspecto crucial en cualquier contexto familiar. Se estudiaron 28 familias homoparentales con hijos o hijas entre los 3 y los 16 años. De ellas, 15 provenían de la Comunidad Andaluza y 13 de la Comunidad de Madrid. Los resultados indican que estas familias disponen de una red amplia de figuras de apoyo, que incluye tanto a familiares como a amistades, así c...

VIII International Congress of Engineering Physics

International Nuclear Information System (INIS)

2017-01-01

The Physicist Engineering is a multidisciplinary profession in which an undergraduate student integrates and applies their knowledge of Physics, Mathematics, and Computing to adapt and innovate all kind of technologies, as well as to development and apply theoretical knowledge to different fields of science and engineering. A Physicist Engineer, supported by a solid preparation in science and engineering is available to study, analyze, identify, and solve problems in different fields of science and technology for industries, hospitals, research laboratories, institutes and governmental organizations focused on metrology, optics, energy, materials, instrumentation of sophisticated equipment. The Physicist Engineering bachelor degree is a national and international reference to encouraging all those students to apply knowledge through active participation in the operation, planning, and management of projects. The technological and scientific impact of a Physicist Engineering undergraduate and graduate students, as well as the tutorial of the research professor that are interested in Physics and Physics Engineering, may be found in a biennial event like the International Conference on Physicist Engineering, through the diffusion of both experimental and theoretical research and teaching. In order to promote and encourage strength academic goals among universities and research institutions, the International Conference on Physics Engineering Committee, integrated by a faculty meeting of the Universidad Autónoma Metropolitana, Campus Azcapotzalco, has decided to grant the VIII International Congress of Physics Engineering to the Universidad Autónoma de Yucatán, which is going to take place on Mérida, November 7 th to 11 th , 2016. This conference considers different topics as: Renewables Energies Engineering Materials Technology Nanotechnology Medical Physics Education in Physics Engineering Nuclear Engineering High Precision Instrumentation Atmosphere Physics

Libros adquiridos por don Pedro Fermín de Vargas en sus viajes por las Antillas

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Sergio Elías Ortíz

1962-04-01

Full Text Available Entre los papeles relacionados con la vida de Don Pedro Fermín de Vargas, que pueden consultarse en el Archivo General de Indias de Sevilla, hay una carta de él y una lista de libros que envía al Administrador de Correos de la Habana, Don José Fuertes, antiguo amigo suyo, luego su corresponsal y a la  vez espía de sus pasos para aprisionarlo, con el objeto de que se los guardase “en algún rincón de sus casa”.

Measurements of the ground-state ionization energy and wavelengths for the 1snp {sup 1}P{sub 1}{sup *}-1s{sup 2} {sup 1}S{sub 0} (n=4-9) lines of Mg XI and F VIII

Energy Technology Data Exchange (ETDEWEB)

Pal' chikov, V.G. [Multicharged Ions Spectra Data Centre of VNIIFTRI, Mendeleevo (Russian Federation)). E-mail: vitpal@mail.ru; Ya Faenov, A.; Yu Skobelev, I. [Multicharged Ions Spectra Data Centre of VNIIFTRI, Mendeleevo (RU)] [and others

2002-06-28

The wavelengths of the 1snp {sup 1}P{sub 1}{sup 0}-1s{sup 2} {sup 1}S{sub 0} transitions in the He-like Mg XI (n = 4-9) and F VIII (n=4-8) have been measured in laser-produced plasmas. The accuracy of the present measurements (0.4-1.6 mA) is a large improvement over previous results. The Rydberg series is used to determine the ground-state ionization energy of F VIII and Mg XI: E{sub i}on (F VIII) 953.96{+-}0.11 eV, E{sub i}on (Mg XI)=1761.88{+-}0.15 eV. These experimental results are compared with theoretical data calculated by the 1/Z-expansion method and the HFR and MCDF approaches. Fairly good agreement between theory and experiment is observed with a precision up to 5x10{sup -5}. Radiative corrections to the 1s{sup 2} {sup 1}S{sub 0} state are analysed and compared with experiments. It is found that QED corrections to the ground-state ionization energy are significant at the present level of experimental accuracy. (author)

Murine leukemia virus-derived retroviral vector has differential integration patterns in human cell lines used to produce recombinant factor VIII

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Marcela Cristina Correa de Freitas

2014-06-01

Full Text Available OBJECTIVE: Nowadays recombinant factor VIII is produced in murine cells including in Chinese hamster ovary (CHO and baby hamster kidney cells (BHK. Previous studies, using the murine leukemia virus-derived retroviral vector pMFG-FVIII-P140K, modified two recombinant human cell lines, HepG2 and Hek293 to produce recombinant factor VIII. In order to characterize these cells, the present study aimed to analyze the integration pattern of retroviral vector pMFG-FVIII-P140K.METHODS: This study used ligation-mediated polymerase chain reaction to locate the site of viral vector integration by sequencing polymerase chain reaction products. The sequences were compared to genomic databases to characterize respective clones.RESULTS: The retroviral vector presented different and non-random profiles of integration between cells lines. A preference of integration for chromosomes 19, 17 and 11 was observed for HepG2FVIIIdB/P140K and chromosome 9 for Hek293FVIIIdB/P140K. In genomic regions such as CpG islands and transcription factor binding sites, there was no difference in the integration profiles for both cell lines. Integration in intronic regions of encoding protein genes (RefSeq genes was also observed in both cell lines. Twenty percent of integrations occurred at fragile sites in the genome of the HepG2 cell line and 17% in Hek293.CONCLUSION: The results suggest that the cell type can affect the profile of chromosomal integration of the retroviral vector used; these differences may interfere in the level of expression of recombinant proteins.

Intensity of factor VIII treatment and the development of inhibitors in non-severe hemophilia A patients: results of the INSIGHT case-control study.

Science.gov (United States)

van Velzen, A S; Eckhardt, C L; Peters, M; Leebeek, F W G; Escuriola-Ettingshausen, C; Hermans, C; Keenan, R; Astermark, J; Male, C; Peerlinck, K; le Cessie, S; van der Bom, J G; Fijnvandraat, K

2017-07-01

Essentials Research suggests that intensive treatment episodes may increase the risk to develop inhibitors. We performed an international nested case-control study with 298 non-severe hemophilia A patients. Surgery and a high dose of factor VIII concentrate were associated with increased inhibitor risk. Physicians need to review arguments for factor VIII dose and elective surgery extra critically. Background Inhibitor development is a major complication of treatment with factor VIII concentrates in hemophilia. Findings from studies among severe hemophilia A patients suggest that intensive treatment episodes increase the risk of developing inhibitors. Objectives We set out to assess whether intensive treatment is also associated with an increased risk of inhibitor development among non-severe hemophilia A patients. Patients/Methods We performed a nested case-control study. A total of 75 inhibitor patients (cases) and 223 control patients were selected from 2709 non-severe hemophilia A patients (FVIII:C, 2-40%) of the INSIGHT cohort study. Cases and controls were matched for date of birth and cumulative number of exposure days (EDs) to FVIII concentrates. Conditional logistic regression was used to calculate both unadjusted and adjusted odds ratios (aOR); the latter were adjusted for a priori specified confounders. Results Peak treatment of 5 or 10 consecutive EDs did not increase inhibitor risk (aOR, 1.0; 95% confidence interval (CI), 0.4-2.5; and aOR, 1.8; CI, 0.6-5.5, respectively). Both surgical intervention (aOR, 4.2; CI, 1.7-10.3) and a high mean dose (> 45 IU kg -1 /ED) of FVIII concentrate (aOR, 7.5; CI, 1.6-35.6) were associated with an increased inhibitor risk. Conclusions Our findings suggest that high-dose FVIII treatment and surgery increase the risk of inhibitor development in non-severe hemophilia A. Together with the notion that non-severe hemophilia A patients are at a lifelong risk of inhibitor development, we suggest that in the future physicians

Pengembangan Perangkat Pembelajaran Matematika Berbasis Concept Attainment Model (CAM untuk Peserta Didik Kelas VIII SMP

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Eka Jihadah Syaspasbandah

2018-01-01

Full Text Available Penelitian ini merupakan penelitian pengembangan yang bertujuan untuk menghasilkan perangkat pembelajaran matematika berbasis Concept Attainment Model (CAM yang valid, praktis, dan efektif terhadap hasil belajar dan aktivitas peserta didik SMP kelas VIII. Perangkat pembelajaran yang dikembangkan mengikuti prosedur pengembangan Model Plomp yang terdiri dari 3 tahap, yaitu tahap analisis pendahuluan, tahap pengembangan atau pembuatan prototipe, dan tahap penilaian. Uji validitas perangkat pembelajaran dilakukan oleh lima orang ahli dari bidang matematika, teknologi pendidikan, dan bahasa Indonesia. Pengujian kepraktisan perangkat pembelajaran diukur dari tiga hal yaitu: keterlaksanaan perangkat pembelajaran, respon peserta didik, dan respon guru. Untuk menilai efektifitas perangkat pembelajaran, dilakukan dengan mengumpulkan data melalui pengamatan terhadap aktivitas belajar matematika peserta didik selama kegiatan pembelajaran dan nilai tes hasil belajar matematika peserta didik. Hasil pegujian tersebut mengidentifikasi bahwa perangkat pembelajaran matematika berbasis CAM yang dikembangkan dinyatakan valid menurut para ahli, praktis berdasarkan guru dan peserta didik sebagai pengguna, dan efektif terlihat dari aktivitas peserta didik selama proses pembelajaran yang mengalami peningkatan. Kata kunci: penelitian pengembangan, Concept Attainment Model, hasil belajar, aktivitas belajar, Model Plomp   ABSTRACT This research is development research aims to produces mathematics learning equipment based on valid, practical, and effective CAM for learning outcome and students activity of VIII grade junior high school. The developed learning equipment uses the procedure of Plomp Model that consists of 3 stages, they are preliminary research, development or prototyping phase, and assessment phase. Validity test of learning equipment is done by 5 experts from mathematics, eduaction technology, and indonesian language. Practical learning equipment test is

The Development of Geometri Teaching Materials Based on Constructivism to Improve the Students' Mathematic Reasoning Ability through Cooperative Learing Jigsaw at the Class VIII of SMP Negeri 3 Padangsidimpuan

Science.gov (United States)

Dewi, Izwita; Harahap, Muhammad Syahri

2016-01-01

The purposes of this research were to know the validity, practicality, and effectivity of geometrical learning material based on the constructivism to Increase students' mathematic reasoning ability and increasing students' mathematic reasoning ability by using learning material at the grade VIII of SMP Negeri 3 Padangsidimpuan. Type of the…

2013 Higher Education Summit/SUS Data Workshop Proceedings. Session: IRM Data Workshop

Science.gov (United States)

Board of Governors, State University System of Florida, 2013

2013-01-01

Information Resource Management--State University System of Florida (IRM-SUS) is the primary collector and provider of data concerning state universities that is used to make sound education policy decisions. The office provides technical assistance to those using the information, state and federal reporting support, those supplying information,…

Proceedings of XIV Workshop on Nuclear Physics. VIII International Symposium on Nuclear and Related Techniques. WONP-NURT 2013

International Nuclear Information System (INIS)

2013-02-01

This year 2013, the XIV Workshop on Nuclear Physics and VIII International Symposium on Nuclear and Related Techniques, WONP-NURT 2013 organized by the Center of Technological Applications and Nuclear Development from 5 to 8 February at the National Museum of Fine Arts. NURT is one of the key Cuban scientific meetings since 1997 dealing with the peaceful applications of nuclear techniques in several domains of the society. WONP and NURT provide an unique opportunity for the national and international scientific community to meet outstanding researchers and discuss current trends in several areas of theoretical, experimental and applied nuclear physics and related topics. The papers submitted to this event are presented in this CD-ROM

Influence of Si content on the intergranular corrosion of SUS 309L stainless steels

International Nuclear Information System (INIS)

Lin, D.-Y.; Chang, T.-C.

2003-01-01

The effect of Si content on the intergranular corrosion resistance of SUS 309L stainless steels was investigated by 10 wt.% oxalic acid test, 65 wt.% boiling nitric acid test, double loop electrochemical potential reactivation (DLEPR) method, optical microscope (OM) and scanning electronic microscope (SEM). A maximum corrosion rate, weight loss of 2.80 g m -1 h, was obtained when SUS 309L stainless steel containing 0.73 wt.% Si was subjected to heat treatment at 800 deg. C for 1 h. It shows that the Cr depletion zone formed due to σ phase precipitation. The same result is obtained in DLEPR test and the ditch microstructure after oxalic test was found in samples that showed the minimum corrosion rate

Virus Zika en Centroamérica y sus complicaciones

OpenAIRE

Núñez, Eduardo; Vásquez, Marilin; Beltrán-Luque, Briana; Padgett, Denis

2016-01-01

El virus Zika (ZIKV) es un arbovirus, aislado por primera vez en Zika Uganda, reportándose el primer caso en humanos en 1954, desde entonces se han descrito casos en África, Asia, Oceanía y en América. Centroamérica ha sido afectada, por cambios climáticos, pobreza y mal saneamiento ambiental. Su transmisión es vectorial y puede tener transmisión perinatal, transfusiones sanguíneas o por semen infectado. Clínicamente se diferencian poco de Dengue y Chikungunya. Sus complicaciones son principa...

Kant, sus maestros y los maestros de la humanidad

OpenAIRE

Ríos Acevedo, Clara Inés

1999-01-01

A instancias de Newton y Rousseau, con sus planteamientos sobre la gravitación universal y la rivindicación del sentimiento y la moralidad, respectivameente, Kant se ocupó de la insociable sociabilidad del ser humano, que genera la dialéctica de la guerra y la paz, antítesis de la ley moral y premisa de todo sistema social; del problema de la paz mundial, promulgando la necesidad de un organismo legal internacional que agrupara todos los Estados del planeta, para así disminuir las guerras y p...

Entusiastas, aficionados y espectadores: sus valores, motivaciones y compromiso

OpenAIRE

Miquel Torregrosa; Jaume Cruz

2009-01-01

El interés de las ciencias aplicadas al deporte en los espectadores y el espectáculo deportivo ha sido más bien escaso y en muchos casos sobrecentrado en la violencia. El objetivo de este trabajo es proponer una clasificación alternativa de los aficionados al fútbol a partir del tipo de contacto que tienen con el espectáculo y describir sus valores, motivaciones y compromiso. Mil setecientas diecinueve personas asistentes a partidos de fútbol organizados por la Liga de Fútbol Profesional con...

PERCEPCIÓN DE LAS MADRES DEL ESTADO NUTRICIONAL DE SUS NIÑOS EN UNA ESCUELA PRIMARIA DE CACHI (SALTA, ARGENTINA

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Sergio A. Giordano

2012-01-01

Full Text Available Introducción: La prevalencia de sobrepeso y obesidad en la infancia ha aumentado en estas últimas décadas. La percepción distorsionada de las madres sobre la imagen corporal y los hábitos alimentarios de sus hijos son predictores de sobrepeso y obesidad. Los objetivos de este trabajo fueron determinar la percepción materna del estado nutricional de sus hijos y compararlo con el estado nutricional evaluado. Métodos: Se realizó un estudio cuantitativo, descriptivo, de corte transversal a 35 madres y sus respectivos hijos que asisten al primer grado de la escuela Victorino de la Plaza en la localidad de Cachi. Las variables fueron edad, sexo, estado nutricional, circunferencia de cintura, percepción materna del estado nutricional de sus hijos, opinión sobre el estado nutricional y percepción materna de la salud en relación con el estado nutricional. Resultados: se pudo observar que el estado nutricional de los 35 niños fue 63% normopeso, 11% bajo peso; 20% sobrepeso, y el 6% obesidad. La alteración de la percepción materna del estado nutricional fue significativamente mayor en los niños con exceso de peso. Conclusiones: Las madres de hijos con sobrepeso y obesidad presentan una distorsión de la imagen corporal de sus niños, en un predominio mayor que las que se presentan en niños con normopeso. Se resalta la importancia del diagnóstico precoz de sobrepeso en niños y la necesidad de su reconocimiento por parte de sus madres.

PENGARUH PENGGUNAAN MODEL COOPERATIVE LEARNING TIPE GROUP INVESTIGATION (GI TERHADAP HASIL BELAJAR IPS TERPADU KELAS VIII SEMESTER GENAP SMPYPI 1 BANDAR MATARAM LAMPUNG TENGAH T.P 2015/2016

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Desi Fatmawati Maryatun

2016-05-01

Full Text Available Metode cooperative learning tipe group investigation merupakan model pembelajaran kooperatif yang dapat melibatkan peserta didik secara aktif dalam kegiatan pembelajaran mulai dari merencanakan topik-topik yang akan dipelajari, bagaimana melaksanakan investigasinya, hingga melakukan presentasi kelompok dan evaluasi. Tujuan penelitian ini adalah untuk mengetahui adanya pengaruh penggunaan model pembelajaran cooperative learning tipe Group Investigation terhadap hasil belajar IPS Terpadu peserta didik kelas VIII semester genap SMP YPI 1 Bandar Mataram  Lampung Tengah tahun pelajaran 2015/2016. Hipotesis yang penulis ajukan adalah “Ada pengaruh yang positif pada model pembelajaran cooperative learning tipe Group Investigation terhadap hasil belajar IPS Terpadu peserta didik kelas VIII semester genap SMP YPI 1 Bandar Mataram  Lampung Tengah tahun pelajaran 2015/2016. Populasi dalam penelitian ini adalah siswa kelas VIII SMP YPI 1 Bandar Mataram Lampung Tengah Tahun Pelajaran 2015/2016 yaitu berjumlah 48 orang siswa dan diantaranya terdiri dari 2 kelas. Dan yang menjadi sampel dalam penelitian ini adalah kelas VIIIa dan VIIIb. Kelas VIIIa sebagai kelas eksperimen dan kelas VIIIb sebagai kelas control, sampel diambil menggunakan teknik purposive sampling, Eksperimen dilaksanakan pada siswa kelas VIIIa Semester Genap SMP YPI 1 Bandar Mataram Lampung Tengah Tahun Pelajaran 2015/2016 yang berjumlah 24 peserta didik. Data penelitian ini dikumpulkan dengan menggunakan  metode observasi, wawancara, dokumentasi, dan tes. Sedangkan untuk mengetahui tingkat validitas dan reliabilitas penulis menggunakan rumus K-R 20. Kemudian untuk menguji/membuktikan hipotesis digunakan rumus Regresi Linier Sederhana yaitu  Ŷ = a + bx. Nilai Ŷ = 73,33+ 0,5 X yang dilanjutkan dengan rumus thitung > ttabel.pada daftar signifikan 5% yaitu 4 > 1,72  dan pada taraf signifikan 1% yaitu 4 > 2,52. Dengan demikian hipotesisnya diterima karena ada pengaruh yang positif

Medicinal Flowers. XXXII. Structures of oleanane-type triterpene saponins, perennisosides VIII, IX, X, XI, and XII, from the flowers of Bellis perennis.

Science.gov (United States)

Morikawa, Toshio; Li, Xuezheng; Nishida, Eriko; Nakamura, Seikou; Ninomiya, Kiyofumi; Matsuda, Hisashi; Hamao, Makoto; Muraoka, Osamu; Hayakawa, Takao; Yoshikawa, Masayuki

2011-01-01

Five new triterpene saponins perennisosides VIII (1), IX (2), X (3), XI (4), and XII (5) were isolated from the MeOH-eluated fraction of the methanolic extract from the flowers of Bellis perennis. The MeOH-eluted fraction of the methanolic extract from the flowers of B. perennis was found to inhibit gastric emptying in olive oil-loaded mice at a dose of 200 mg/kg, per os (p.o.). The stereostructures of 1-5 were elucidated on the basis of chemical and spectroscopic evidence.

Total cross-sections assessment of neutron reaction with stainless steel SUS-310 contained in various nuclear data files

International Nuclear Information System (INIS)

Suwoto

2002-01-01

The integral testing of neutron cross-sections for Stainless Steel SUS-310 contained in various nuclear data files have been performed. The shielding benchmark calculations for Stainless Steel SUS-310 has been analysed through ORNL-Broomstick Experiment calculation which performed by MAERKER, R.E. at ORNL - USA ( 1) . Assessment with JENDL-3.1, JENDL-3.2, ENDF/B-IV, ENDF/B-VI nuclear data files and data from GEEL have also been carried out. The overall calculation results SUS-310 show in a good agreement with the experimental data, although, underestimate results appear below 3 MeV for all nuclear data files. These underestimation tendencies clearly caused by presented of iron nuclide which more than half in Stainless Steel compound. The total neutron cross-sections of iron nuclide contained in various nuclear data files relatively lower on that energy ranges

A experiência da pesquisa EnsinaSUS The experience of EnsinaSUS research

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Lilian Koifman

2007-06-01

Full Text Available Este artigo descreve a trajetória do projeto EnsinaSUS, da pesquisa desenvolvida em seu interior e das múltiplas dimensões e implicações na direção do conhecimento das experiências que têm sido realizadas nos cursos da área de saúde em relação aos processos de mudança que estão em desenvolvimento. Pretendemos compartilhar a experiência de integração de pesquisadores, de diferentes origens institucionais e profissionais, na construção de um projeto comum, alimentado da vivência desses atores. Essa experiência almejou inovar e construir uma nova gramática para discussão e compreensão dos processos pedagógicos e sua interface com a saúde e o trabalho, na produção de um cuidado que se faça distinto na concepção da assistência à saúde, produzindo cuidado usuário-centrado, numa perspectiva dialógica e ético-política. Entendemos que as práticas de ensino e extensão funcionam como dispositivos abertos de um 'fazer-pensar-saber' em integralidade, forjando novas concepções, sentidos e significados da saúde, da vida, do conhecimento e da educação. Pautamo-nos na idéia de que as explicações da práxis pedagógica podem ser entendidas como possibilidade da construção histórica da cidadania. Encontramos alguns mecanismos de legitimação e canais de articulação, intercâmbio e solidariedade como resposta de interação de diversidades. A equipe representou a composição de redes de representação em espaços culturais e políticos plurais.This article describes the EnsinaSUS Project, the research developed within the project, and the various dimensions and implications that will lead to understanding the experiences that have been taking place in courses in the field of health care as regards their processes of change. Our aim is to share the experience of integrating researchers, coming from different institutional and professional backgrounds, in order to build a common project, based on their

Los filósofos griegos y sus escuelas

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Solana Dueso, José

2008-06-01

Full Text Available The Greek philosophy developed three types of philosophical schools. The first one, represented by the Milesians, the Eleatics and partly the Aristotle’s Lyceum, understands the philosophical activity as a set of projects of investigation, not necessarily lacking of pragmatic interest, moved by desire to explain the phenomena. Next to their activities of investigation, many of these philosophers maintain a political activity within the framework of their own cities. The second type, represented by the Pythagoreans and the Academy of Plato, aims to reach the union between knowledge and political power. This proposal finds its better synthesis in the ideal of philosopher king. At the hellenistic period, the goal of philosophical schools would be to offer the cultivated and instructed man a particular way of life.La filosofía griega desarrolló tres tipos de escuelas filosóficas. El primero, representado por los milesios, los eleáticos y, en parte, el Liceo de Aristóteles, entiende la actividad filosófica como un conjunto de proyectos de investigación, no necesariamente carentes de interés pragmático, movidos por el deseo de explicar los fenómenos. Junto a sus actividades de investigación, muchos de estos filósofos mantienen una actividad política en el marco de las instituciones de sus propias ciudades. El segundo tipo, representado por los pitagóricos y la Academia platónica, se propone alcanzar la unión entre el saber y el poder. Esta propuesta halla su mejor síntesis en el ideal del filósofo rey. Finalmente, en la época helenística, las escuelas filosóficas se proponen sobre todo ofrecer un ideal de vida al hombre culto e instruido de su tiempo.

Lean Manufacturing measurement: The relationships between Lean activities and Lean metrics

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Diego Fernando Manotas Duque

2007-01-01

Full Text Available Medición en Lean Manufacturing: Relaciones entre Actividades Lean y Métricas Lean Lean Manufacturing fue desarrollada por Toyota para satisfacer sus necesidades específicas en un mercado restringido y en tiempos de estrechez económica. Estos conceptos han sido estudiados y se ha comprobado su aplicabilidad en una amplia variedad de industrias. El objetivo de este artículo es el de integrar un conjunto de métricas que han sido propuestas por diferentes autores, de tal manera que sean consistentes con las etapas y elementos de implementaciones de Lean Manufacturing. Para lograrlo se presentan dos marcos de referencia para implementaciones Lean y los principales factores de éxito se utilizan como base para proponer métricas que identifiquen el avance en estos factores. Posteriormente se propone una tabla que cruza el impacto de las “Actividades Lean” sobre las métricas, postulando que muchos de los supuestos a priori sobre estos impactos deberían ser precisos. Finalmente se proponen algunas ideas para proyectos de investigación hacia el futuro y posibles extensiones de las aplicaciones propuestas aquí.

First isolation of Trichinella britovi from a wild boar (Sus scrofa) in Belgium.

NARCIS (Netherlands)

Schynts, F; Giessen, Joke van der; Tixhon, S; Pozio, E; Dorny, P; Borchgrave, J de

2006-01-01

Since 1992, when the European Union Council Directive requires that wild boars (Sus scrofa) hunted in EU for commercial purpose should be examined for Trichinella, the infection has not been detected in wild boars from Belgium, despite serological evidence of the presence of anti-Trichinella

O entendimento do direito à saúde: uma abordagem dos usuários do SUS no Distrito Federal

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Rosa Shirley Silva

2015-09-01

Full Text Available O direito à saúde é um direito fundamental, conquistado por meio da participação social que resultou em sua inserção na atual Constituição Federal, e na instituição do SUS. Este estudo objetivou analisar a percepção dos usuários do SUS, no Distrito Federal, sobre o direito à saúde e o impacto desse entendimento na dinâmica da construção do sistema. Foram realizadas entrevistas, com 75 usuários, entre setembro e outubro de 2014. Como roteiro de pesquisa utilizou-se o método qualiquantitativo de abordagem descritiva exploratória. Os dados coletados, através de formulário semiestruturado, foram tratados com sistema planilhas do Microsoft Office Excel versão 2010 e para auxiliar a pergunta aberta utilizou-se a técnica do Discurso do Sujeito Coletivo (DSC. Os tópicos de interesse foram: o conceito de saúde, o SUS, informação em saúde e participação social. Verificou-se, portanto, que a maioria dos usuários do SUS não reconhece a saúde como direito. O entendimento de SUS como política criada para garantir o direito à saúde é substituído pela ideia de concessão do Estado. Aliado à isso, o desconhecimento das leis de saúde, a falta de consciência sanitária e a sensação de resignação e submissão de sua situação de saúde reforçam este pensamento. O impacto desse entendimento na dinâmica da construção do sistema acontece pela baixa capacidade de organização e pouco conhecimento e participação no Conselho de Saúde. Foi possível concluir que o desconhecimento do direito à saúde compromete e enfraquece o processo de desenvolvimento do SUS, que se fundamenta no princípio da participação e controle social.

Short-range order in alloys of nickel with the elements of group VIII of the periodic table

International Nuclear Information System (INIS)

Khwaja, F.A.

1981-08-01

Experimental measurements of the diffuse X-ray scattering intensity were performed on alloys of Ni with Rh and Os. The atomic short-range order (SRO) parameters αsub(i) and the size-effect parameters βsub(i) were calculated from these measurements. It is established that SRO and size-effect exist in Ni-Rh and Ni-Os alloys analogously as in a few other alloys of Ni with the elements of group VIII of the periodic table. The experimental data was interpreted theoretically by calculating the interaction energies from the pseudo-potentials and the effective valencies of the individual components of the systems studied. It was found that theoretically calculated values of the interaction energies for these alloys are inconsistent with the experimentally determined sign of the SRO parameter. (author)

Scanning Ultrasound (SUS Causes No Changes to Neuronal Excitability and Prevents Age-Related Reductions in Hippocampal CA1 Dendritic Structure in Wild-Type Mice.

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Robert John Hatch

Full Text Available Scanning ultrasound (SUS is a noninvasive approach that has recently been shown to ameliorate histopathological changes and restore memory functions in an Alzheimer's disease mouse model. Although no overt neuronal damage was reported, the short- and long-term effects of SUS on neuronal excitability and dendritic tree morphology had not been investigated. To address this, we performed patch-clamp recordings from hippocampal CA1 pyramidal neurons in wild-type mice 2 and 24 hours after a single SUS treatment, and one week and 3 months after six weekly SUS treatments, including sham treatments as controls. In both treatment regimes, no changes in CA1 neuronal excitability were observed in SUS-treated neurons when compared to sham-treated neurons at any time-point. For the multiple treatment groups, we also determined the dendritic morphology and spine densities of the neurons from which we had recorded. The apical trees of sham-treated neurons were reduced at the 3 month time-point when compared to one week; however, surprisingly, no longitudinal change was detected in the apical dendritic trees of SUS-treated neurons. In contrast, the length and complexity of the basal dendritic trees were not affected by SUS treatment at either time-point. The apical dendritic spine densities were reduced, independent of the treatment group, at 3 months compared to one week. Collectively, these data suggest that ultrasound can be employed to prevent an age-associated loss of dendritic structure without impairing neuronal excitability.

Expressão citofotométrica dos marcadores tumorais CD-34 e fator VIII no câncer de cólon

OpenAIRE

Garcia,Cacilda Joyce Ferreira da Silva; Cuenca,Ronaldo M.; Bora,Fabio Roberto; Ribas-Filho,Jurandir Marcondes; Czeczko,Nicolau Gregori; Ribas,Carmen Austrália Paredes Marcondes; Wagenführ Jr.,Jorge

2009-01-01

OBJETIVOS: Verificar a posssibilidade de quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII no câncer de cólon; verificar se existe superioridade entre um marcador e outro para estudo da angiogênese; verificar se há correlação na análise do índice de marcagem e a densidade óptica média nos marcadores utilizados. MÉTODOS: Dezessete casos de adenocarcinoma colorretal recuperados de blocos de parafina e confirmados pela hematoxilina-eosina, foram submetidos à coloração imunoistoq...

Symposium by NATO Defense Research Group Panel VIII on Computer-Based Instruction in Military Environments

CERN Document Server

Weddle, Peter

1987-01-01

This collection of papers is the result of a symposium sponsored by NATO's Defense Research Group Panel VIII in the Spring of 1985. The symposium came into being when it became obvious to the NATO countries that research, development and utilization of advanced technologies for training was the best means of increasing both training effectiveness and efficiency. This symposium was the second in a series of three devoted to training. The series was structured to cover all aspects of training. The first series addressed the value of training, the second one dealt with the application of training technologies and the third and last of the series focused on academic issues concerned with the effect of prior learning on subsequent learning. The fact that a major American publisher has determined that computer based instruction is the technology of greatest interest to the NATO community is not surprising. Advances in microprocessor technology have revolutionized both how and where we train. During this symposium t...

The 4p5rd10 and 4d86p configurations of Te VIII

International Nuclear Information System (INIS)

Churilov, S.S.; Rossijskaya Akademiya Nauk, Troitsk; Joshi, Y.N.; Kildiyarova, R.R.

1998-01-01

The spectrum of tellurium was photographed in the 100-500 A region on a variety of grazing incidence spectrographs using a triggered spark source. The analysis of the lines in the 117-216 A region has lead to establishing 42 out of 45 levels of the 4d 8 6p configuration of Te VIII. Four levels of the 4d 8 4f configuration were confirmed and their level values revised, and an additional 4d 8 4f level was established. The 4p 5 4d 10 levels reported earlier were found to be erroneous and new values have been found for them. Eighty seven (87) new lines have been classified in the (4d 9 + 4d 8 5s)-(4d 8 4f + 4p 5 4d 10 + 4d 8 6p) transition array. Hartree-Fock with relativistic corrections (HFR) and parametric least-squares-fitted (lSF) calculations were carried out to interpret the present analysis adequately. (orig.)

Invención y tradición en la cancillería real de Alfonso VIII de Castilla (1158-1214

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Pablo Martín Prieto

2013-11-01

Full Text Available El estudio de la evolución de la cancillería real de Castilla bajo Alfonso VIII permite derivar ciertas conclusiones sobre el papel individual de los miembros de su personal en la redacción de los diplomas regios, concretamente por medio de un análisis detenido de los preámbulos, su formación y alteraciones a lo largo del tiempo en la mano de los distintos scriptores. Asimismo, esta base permite medir el equilibrio entre tradición e innovación en el trabajo de cancillería. La consideración de la imagen del monarca ideal, tal como se propone tanto en fuentes literarias como en los mismos documentos de la cancillería, conduce a una comprensión más clara del alcance de la propaganda política de la época en el más amplio contexto cultural de la corte castellana.The study of the Castilian royal Chancery’s evolution under King Alfonso VIII allows us to draw certain conclusions on the role of individual members of that office in the process of drafting royal documents. We will present a detailed description of preambles, their elaboration and evolution in time and by the hands of different scriptores. This will also allow us to gauge the balance between tradition and innovation within the Chancery. A more thorough grasp of the scope of political propaganda at the time can be determined through the image of the ideal king as depicted both in literary sources and in Chancery documents within the wider context of cultural developments in the Castilian court.

Processing and benchmarking of evaluated nuclear data file/b-viii.0β4 cross-section library by analysis of a series of critical experimental benchmark using the monte carlo code MCNP(X and NJOY2016

Directory of Open Access Journals (Sweden)

Kabach Ouadie

2017-12-01

Full Text Available To validate the new Evaluated Nuclear Data File (ENDF/B-VIII.0β4 library, 31 different critical cores were selected and used for a benchmark test of the important parameter keff. The four utilized libraries are processed using Nuclear Data Processing Code (NJOY2016. The results obtained with the ENDF/B-VIII.0β4 library were compared against those calculated with ENDF/B-VI.8, ENDF/B-VII.0, and ENDF/B-VII.1 libraries using the Monte Carlo N-Particle (MCNP(X code. All the MCNP(X calculations of keff values with these four libraries were compared with the experimentally measured results, which are available in the International Critically Safety Benchmark Evaluation Project. The obtained results are discussed and analyzed in this paper.

[Determinants of the elevated factor VIII activity in patients following venous thromboembolism].

Science.gov (United States)

Lech, Monika; Kościelniak, Barbara; Bryk, Agata; Undas, Anetta

2016-01-01

Activity of factor VIII (FVIII) increased above 150% of reference range predisposes to venous thromboembolism (VTE). The aim of this study was to identify predictors of increased FVIII activity in patients following VTE. 241 (38% men) patients presented due to objectively documented VTE episode at least 3 months ago were included in this study. FVIII activity was measured using a clotting assay on the analyzer BCS XP. Among 241 patients with VTE, activity of FVIII above 150% (FVIII ≥ 150%) was observed in 96 (40%). These patients were older (p = 0.035) and their concentrations of fibrinogen and C-reactive protein (CRP) were higher by 12% and 88% (p 200%) and this group was also older (p = 0.015), more patients in that group had obesity (p = 0.015), idiopathic VTE (p = 0.043), less of them had positive family history (p = 0.010) and they were characterized by fibrinogen and CRP increased by 28% (p 200% (p = 0.016). The activity of FVIII in patients after VTE episode is influenced by age, concentration of fibrinogen, bilirubin, hemoglobin, glucose, CRP and homocysteine. Our results suggest the role of environmental factors, mainly inflammatory response in maintaining elevated FVIII activity following VTE.

La memoria de Vejer en sus primeras tarjetas postales

OpenAIRE

Gámiz-Gordo, Antonio

2013-01-01

Se acaba de imprimir este libro sobre imágenes del pasado del gaditano pueblo de Vejer de la Frontera, donde el profesor Gámiz reúne un novedoso plano de la ciudad de 1907 y 40 tarjetas postales fechadas entre 1904 y 1930 (muchas de ellas con puntos de toma localizables en el plano citado, al ser callejero de la época), además de comentarios y reflexiones que el autor realiza sobre las imágenes gráficas, contexto e historia. Así, se abordan temas como memoria e imagen, sus relaciones e int...

Migrantes culiacanenses en California: Diversidad en sus redes migratorias

OpenAIRE

Sánchez Sánchez, Ernesto

2012-01-01

Es un hecho la dinámica extraordinaria que tienen los lugares de reciente migración, ya sea como lugares de origen o destino. El estado de Sinaloa se suma a esta dinámica en la cual aparecen ahora sus tres principales zonas urbanas -Culiacán, Mazatlán y Ahome- dentro de su mapa migratorio. Sin embargo la migración, como proceso social, implica una serie de interrelaciones formadas tiempo atrás. Éstas repercuten en la conformación de las nuevas redes migratorias. No obstante, durante décadas, ...

SUS in nuclear medicine in Brazil: analysis and comparison of data provided by Datasus and CNEN.

Science.gov (United States)

Pozzo, Lorena; Coura Filho, George; Osso Júnior, João Alberto; Squair, Peterson Lima

2014-01-01

To investigate the outpatient access to nuclear medicine procedures by means of the Brazilian Unified Health System (SUS), analyzing the correspondence between data provided by this system and those from Comissão Nacional de Energia Nuclear (CNEN) (National Commission of Nuclear Energy). Data provided by Datasus regarding number of scintillation chambers, outpatient procedures performed from 2008 to 2012, administrative responsibility for such procedures, type of service providers and outsourced services were retrieved and evaluated. Also, such data were compared with those from institutions certified by CNEN. The present study demonstrated that the system still lacks maturity in terms of correct data input, particularly regarding equipment available. It was possible to list the most common procedures and check the growth of the specialty along the study period. Private centers are responsible for most of the procedures covered and reimbursed by SUS. However, many healthcare facilities are not certified by CNEN. Datasus provides relevant data for analysis as done in the present study, although some issues still require attention. The present study has quantitatively depicted the Brazilian reality regarding access to nuclear medicine procedures offered by/for SUS.

SUS in nuclear medicine in Brazil: analysis and comparison of data provided by Datasus and CNEN*

Science.gov (United States)

Pozzo, Lorena; Coura Filho, George; Osso Júnior, João Alberto; Squair, Peterson Lima

2014-01-01

Objective To investigate the outpatient access to nuclear medicine procedures by means of the Brazilian Unified Health System (SUS), analyzing the correspondence between data provided by this system and those from Comissão Nacional de Energia Nuclear (CNEN) (National Commission of Nuclear Energy). Materials and Methods Data provided by Datasus regarding number of scintillation chambers, outpatient procedures performed from 2008 to 2012, administrative responsibility for such procedures, type of service providers and outsourced services were retrieved and evaluated. Also, such data were compared with those from institutions certified by CNEN. Results The present study demonstrated that the system still lacks maturity in terms of correct data input, particularly regarding equipment available. It was possible to list the most common procedures and check the growth of the specialty along the study period. Private centers are responsible for most of the procedures covered and reimbursed by SUS. However, many healthcare facilities are not certified by CNEN. Conclusion Datasus provides relevant data for analysis as done in the present study, although some issues still require attention. The present study has quantitatively depicted the Brazilian reality regarding access to nuclear medicine procedures offered by/for SUS. PMID:25741070

Propuesta de teorías integradoras para la cefalogénesis y sus malformaciones

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Dadonim Vila Morales

2013-03-01

Full Text Available En las teorías embriogénicas de las malformaciones del macizo craneofacial es frecuente encontrar explicaciones simplistas, que no aluden a la biología celular, ni molecular de sus fisiopatologías. El propósito de esta investigación fue describir las teorías de la cefalogénesis y sus malformaciones craneofaciales, como requisito para proponerteorías integradoras que favorezcan su mejor comprensión. Se realizó una revisión biobliográfica sobre el tema de la cefalogénesis y las concepciones científicas actuales concernientes a las teorías de las malformaciones congénitas craneofaciales. Se realizó una revisión en Internet, en el periodo comprendido entre diciembre de 2011 y enero de 2012. Se analizaron los artículos de revistas de la Web of Sciences que trataron este tema desde el año 2006 hasta el 2012 en los buscadores Google academico, Hinari, Scopus, Scielo y Medline. Como resultado se obtuvieron 131 artículos que fueron tamizados; pero el estudio se ciñó solo a 43 artículos que enfocaron estas temáticas de manera más integral. Se consideraron reduccionitas o incompletas las teorías hasta ahora expuestas. Por tal motivo se propusieron teorías holístico-sinérgicas de la cefalogénesis y sus malformaciones.

Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms.

Science.gov (United States)

Albánez, S; Ogiwara, K; Michels, A; Hopman, W; Grabell, J; James, P; Lillicrap, D

2016-05-01

Essentials von Willebrand factor (VWF) and factor VIII (FVIII) levels are modulated by age and ABO status. The effect of aging and ABO blood type on VWF and FVIII was assessed in 207 normal individuals. Aging and ABO blood type showed combined and bidirectional influences on VWF and FVIII levels. Aging and ABO blood type influence VWF levels through both secretion and clearance mechanisms. Background The effect of aging and ABO blood type on plasma levels of von Willebrand factor (VWF) and factor VIII (FVIII) have been widely reported; however, a comprehensive analysis of their combined effect has not been performed and the mechanisms responsible for the age-related changes have not been determined. Objectives To assess the influence of aging and ABO blood type on VWF and FVIII levels, and to evaluate the contribution of VWF secretion and clearance to the age-related changes. Methods A cross-sectional observational study was performed in a cohort of 207 normal individuals, whose levels of VWF, FVIII, VWF propeptide (VWFpp), VWFpp/VWF:Ag ratio and blood type A antigen content on VWF (A-VWF) were quantified. Results Aging and ABO blood type exerted interrelated effects on VWF and FVIII plasma levels, because the age-related increase in both proteins was significantly higher in type non-O individuals (β = 0.011 vs. 0.005). This increase with age in non-O subjects drove the differences between blood types in VWF levels, as the mean difference increased from 0.13 U/mL in the young to 0.57 U/mL in the old. Moreover, A-VWF was associated with both VWF antigen (β = 0.29; 95% confidence interval [CI], 0.09, 0.50) and VWF clearance (β = -0.15; 95% CI, -0.25, -0.06). We also documented an effect of ABO blood type on VWF secretion with aging, as old individuals with blood type non-O showed higher levels of VWFpp (mean difference 0.29 U/mL). Conclusions Aging and ABO blood type have an interrelated effect on VWF and FVIII levels, where the effect of one is significantly

The effect of aging treatment on the high temperature fatigue strength and fatigue fracture behaviour of friction welded domestic heat resisting steels (SUH3-SUS303)

International Nuclear Information System (INIS)

Lee, K.Y.; Oh, S.K.; Kim, H.J.

1981-01-01

In this study the experiment was carried out as the high temperature rotary bending fatigue testing under the condition of 700 0 C high temperature to the friction welded domestic heat resisting steels, SUH3-SUS303, which were 10 hr., 100 hr. aging heat treated at 700 0 C after solution treatment 1 hr. at 1060 0 C for the purpose of observing the effects of the high temperature fatigue strength and fatigue fracture behaviours as well as with various mechanical properties of welded joints. The results obtained are summarized as follows: 1) Through mechanical tests and microstructural examinations, the determined optimum welding conditions, rotating speed 2420 rpm, heating pressure 8 kg/mm 2 , upsetting pressure 22 kg/mm 2 , the amount of total upset 7 mm (heating time 3 sec and upsetting time 2 sec) were satisfied. 2) The solution treated material SUH3, SUS303 and SUH3-SUS303, have the highest inclination gradiant on S-N curve due to the high temperature fatigue testing for long time at 700 0 C. 3) The optimum aging time of friction welded SUH3-SUS303, has been recognized near the 10 hr. at 700 0 C after the solution treatment of 1 hr. at 1060 0 C. 4) The high temperature fatigue limits of aging treated materials were compared with those of raw material according to the extender of aging time, on 10 hr. aging, fatigue limits were increased by SUH3 75.4%, SUS303 28.5%, friction welded joints SUH3-SUS303 44.2% and 100 hr. aging the rate were 64.9%, 30.4% and 36.6% respectively. 5) The fatigue fractures occurred at the side of the base metal SUS303 of the friction welded joints SUH3-SUS303 and it is difficult to find out fractures at the friction welding interfaces. 6) The cracking mode of SUS303, SUH3-SUS303 is intergranular in any case, but SUH3 is fractured by transgranular cracking. (author)

Una Aproximación a la Agenda Institucional de la Comisión de Defensa del Congreso de los Diputados Español, 2004-2016

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Javier Jordán

2017-05-01

Full Text Available El artículo estudia el contenido de la agenda de la Comisión de Defensa del Congreso de los Diputados entre las VIII y XI Legislaturas. Analiza la distribución de los asuntos tratados, quiénes han sido los protagonistas de la fijación de la agenda, cuáles han sido sus preferencias, y en qué medida han estado presentes en la agenda los asuntos centrales de la política de Defensa española

PENERAPAN PENDEKATAN CINEMATHERAPY UNTUK MENINGKATKAN PERILAKU PROSOSIAL PADA SISWA KELAS VIII DI BOSOWA INTERNATIONAL SCHOOL MAKASSAR

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Haeruddin Niva

2016-06-01

Full Text Available The objectives of the research are: (i to know the prosocial behavioral level of the students in Bosowa International School Makassar before and after giving cinematography approach, and (ii to know whether or not the approach is able to enhance the prosocial behavior of the students in Bosowa International School Makassar. The research is a quantitative research using experimental method. The research design used is quasi experimental design with non-equivalent control group design. The data collection technique applied is scale and FGD (Focus Group Discussion. The findings shows that (i the prosocial behavioral level of the students was low in pretest while after giving treatment there were significant increase to the prosocial behavior in the experimental group, and (ii the cinematography approach was able to increase the prosocial behavior of the Grade VIII students in Bosowa Internatinal School Makassar. 

El etnólogo y sus fantasmas. Leiris en África

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Giobellina Brumana, Fernando

2001-12-01

Full Text Available The Dakar-Djibouti expedition, led by Marcel Griaule, crossed Africa between 1931 and 1933. One of the participants was Michel Leiris, a young poet who had just severed his relations with the surrealist avantgarde and was in the throes of a personal crisis. This paper is about his experience in that joumey of discovery of himself, of the other and of ethnography. Representation and margination: these are the themes that will endure in L'Afrique fantôme as well as in Leiris' other writings about the Dogon and the Zar cult.

La Misión Dakar-Yibuti, bajo la dirección de Marcel Griaule, atravesó el continente africano entre 1931 y 1933. En sus filas se encontraba Michel Leiris, joven poeta que acababa de romper con la cúpula surrealista y pasaba por malos tiempos personales. Este artículo registra su experiencia en este viaje de descubrimiento de sí, del otro y de la etnografía. Representación y marginalidad, esos son los elementos que quedarán, tanto en L'Afrique fantôme como en sus otros escritos sobre los dogon y el culto zar.

Seguridad y Confianza: cara y cruz de la sociedad de la informaci??n desde sus antecedentes hist??ricos

OpenAIRE

D??az Nafr??a, Jos?? Mar??a

2011-01-01

Ponencia de Jos?? Mar??a D??az Nafr??a (Investigador, ULE; Profesor de la Facultad de estudios interdisciplinares de la Universidad Polit??cnica de Munich). Se analizan diferentes sentidos de la noci??n de seguridad y sus presupuestos, metodolog??as y contextos mediante una primera revisi??n de las nociones liberalistas de seguridad y confianza desde sus planteamientos cl??sicos. A partir de estos se abordan tanto los ideales a los que estos apuntan como el espectro de utop??as y distop??as a...

TIRO Y LAS FLUCTUACIONES DE LA ECONOMÍA FENICIA DURANTE EL SIGLO VIII ANTES DE NUESTRA ERA (Tyre and the Fluctuations of Phoenician Economy during the 8th Century BC

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Pascual Izquierdo-Egea

2014-12-01

Full Text Available La aplicación del método de valoración contextual al análisis de los ajuares funerarios hasta ahora publicados de la necrópolis fenicia de Tiro-Al Bass, Líbano, permite aislar las fluctuaciones económicas y los cambios sociales experimentados por la población tiria durante el siglo VIII a. C. En concreto, se detecta una larga prosperidad desde mediados del siglo IX hasta mediados del VIII antes de nuestra era, con un máximo de bonanza a lo largo del periodo 775-750 a. C. En cambio, la segunda mitad del siglo VIII muestra una aguda crisis económica asociada a una elevada conflictividad social. Estos resultados coinciden plenamente con los acontecimientos históricos conocidos a través de las fuentes literarias antiguas, aportando evidencias que las complementan. En todo caso, con este nuevo ejemplo se confirma, una vez más, la universalidad de la metodología empleada y su irrefutable validez científica. ENGLISH: By applying the contextual valuation method to the analysis of grave goods from the Phoenician cemetery of Tyre-Al Bass, Lebanon, we can isolate the economic fluctuations and social changes experienced by the Tyrian population during the 8th century BC. Based on the evidence, the mid-9th to the mid-8th century BC was a period of prosperity, with the most pronounced economic boom between 775-750 BC. In contrast, the second half of the 8th century BC shows a sharp economic crisis associated with a high level of social conflict. These results are fully consistent with the historical events known through ancient literary sources. This new example confirms the universality of this methodology and its irrefutable scientific validity.

Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research

DEFF Research Database (Denmark)

Kornum, Birgitte R; Knudsen, Gitte M

2011-01-01

Within neuroscience and biobehavioral research, the pig (Sus scrofus) is increasingly being acknowledged as a valuable large animal species. Compared to the rodent brain, the pig brain more closely resembles the human brain in terms of both anatomy and biochemistry, which associates the pig...... of farm animal welfare researchers, but it has only recently received interest in the wider neuroscience community. Several behavioral tasks have successfully been adapted to the pig, and valuable results have been produced. However, most tasks have only been established at a single research facility...

Padres hombres custodios - PHC: la paternidad, sus alcances y motivaciones

OpenAIRE

Fierro Barahona, José Gustavo; Ruíz Gómez, Marina Stella

2015-01-01

Esta investigación comprendió las concepciones sobre paternidad presentes en los padres hombres al solicitar la custodia de sus hijas e hijos menores de siete años ante el ICBF de la ciudad de Cali con un diseño cualitativo de aproximación fenomenológica, se utilizó el instrumento de entrevista en profundidad con cinco padres hombres custodios - PHC. Los resultados se presentaron en relación a las distinciones expresadas por los PHC acerca de las razones que los llevó a solicit...

Comportamiento productivo en híbridos de jitomate y sus respectivas poblaciones F2

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J. Martínez-Solís

2005-01-01

Full Text Available Debido a que el precio de semilla híbrida de jitomate es muy alto, muchos agricultores utilizan generaciones F2 en parcelas comerciales. Por esta razón con el propósito de evaluar el comportamiento entre genotipos de jitomate F1 y F2, 37 híbridos y sus respectivas generaciones F2 fueron establecidos en invernadero. La mayoría de las generaciones F2 presentaron menor peso total de fruto por planta y número de frutos por planta con respecto a sus F1; sin embargo, el efecto fue estadísticamente significativo sólo en dos genotipos tipo bola de hábito de crecimiento determinado y cuatro genotipos tipo bola de hábito de crecimiento indeterminado, los cuales abatieron su producción de fruto de F2 en al menos 20 %

Driven equilibrium (drive) MR imaging of the cranial nerves V-VIII: comparison with the T2-weighted 3D TSE sequence

Energy Technology Data Exchange (ETDEWEB)

Ciftci, E. E-mail: eciftcis7@hotmail.com; Anik, Yonca; Arslan, Arzu; Akansel, Gur; Sarisoy, Tahsin; Demirci, Ali

2004-09-01

Purpose: The aim of this study is to evaluate the efficacy of the driven equilibrium radio frequency reset pulse (DRIVE) on image quality and nerve detection when used in adjunction with T2-weighted 3D turbo spin-echo (TSE) sequence. Materials and methods: Forty-five patients with cranial nerve symptoms referable to the cerebellopontine angle (CPA) were examined using a T2-weighted 3D TSE pulse sequence with and without DRIVE. MR imaging was performed on a 1.5-T MRI scanner. In addition to the axial resource images, reformatted oblique sagittal, oblique coronal and maximum intensity projection (MIP) images of the inner ear were evaluated. The nerve identification and image quality were graded for the cranial nerves V-VIII as well as inner ear structures. These structures were chosen because fluid-solid interfaces existed due to the CSF around (the cranial nerves V-VIII) or the endolymph within (the inner ear structures). Statistical analysis was performed using the Wilcoxon test. P<0.05 was considered significant. Results: The addition of the DRIVE pulse shortens the scan time by 25%. T2-weighted 3D TSE sequence with DRIVE performed slightly better than the T2-weighted 3D TSE sequence without DRIVE in identifying the individual nerves. The image quality was also slightly better with DRIVE. Conclusion: The addition of the DRIVE pulse to the T2-weighted 3D TSE sequence is preferable when imaging the cranial nerves surrounded by the CSF, or fluid-filled structures because of shorter scan time and better image quality due to reduced flow artifacts.

Driven equilibrium (drive) MR imaging of the cranial nerves V-VIII: comparison with the T2-weighted 3D TSE sequence

International Nuclear Information System (INIS)

Ciftci, E.; Anik, Yonca; Arslan, Arzu; Akansel, Gur; Sarisoy, Tahsin; Demirci, Ali

2004-01-01

Purpose: The aim of this study is to evaluate the efficacy of the driven equilibrium radio frequency reset pulse (DRIVE) on image quality and nerve detection when used in adjunction with T2-weighted 3D turbo spin-echo (TSE) sequence. Materials and methods: Forty-five patients with cranial nerve symptoms referable to the cerebellopontine angle (CPA) were examined using a T2-weighted 3D TSE pulse sequence with and without DRIVE. MR imaging was performed on a 1.5-T MRI scanner. In addition to the axial resource images, reformatted oblique sagittal, oblique coronal and maximum intensity projection (MIP) images of the inner ear were evaluated. The nerve identification and image quality were graded for the cranial nerves V-VIII as well as inner ear structures. These structures were chosen because fluid-solid interfaces existed due to the CSF around (the cranial nerves V-VIII) or the endolymph within (the inner ear structures). Statistical analysis was performed using the Wilcoxon test. P<0.05 was considered significant. Results: The addition of the DRIVE pulse shortens the scan time by 25%. T2-weighted 3D TSE sequence with DRIVE performed slightly better than the T2-weighted 3D TSE sequence without DRIVE in identifying the individual nerves. The image quality was also slightly better with DRIVE. Conclusion: The addition of the DRIVE pulse to the T2-weighted 3D TSE sequence is preferable when imaging the cranial nerves surrounded by the CSF, or fluid-filled structures because of shorter scan time and better image quality due to reduced flow artifacts

Targeting factor VIII expression to platelets for hemophilia A gene therapy does not induce an apparent thrombotic risk in mice.

Science.gov (United States)

Baumgartner, C K; Mattson, J G; Weiler, H; Shi, Q; Montgomery, R R

2017-01-01

Essentials Platelet-Factor (F) VIII gene therapy is a promising treatment in hemophilia A. This study aims to evaluate if platelet-FVIII expression would increase the risk for thrombosis. Targeting FVIII expression to platelets does not induce or elevate thrombosis risk. Platelets expressing FVIII are neither hyper-activated nor hyper-responsive. Background Targeting factor (F) VIII expression to platelets is a promising gene therapy approach for hemophilia A, and is successful even in the presence of inhibitors. It is well known that platelets play important roles not only in hemostasis, but also in thrombosis and inflammation. Objective To evaluate whether platelet-FVIII expression might increase thrombotic risk and thereby compromise the safety of this approach. Methods In this study, platelet-FVIII-expressing transgenic mice were examined either in steady-state conditions or under prothrombotic conditions induced by inflammation or the FV Leiden mutation. Native whole blood thrombin generation assay, rotational thromboelastometry analysis and ferric chloride-induced vessel injury were used to evaluate the hemostatic properties. Various parameters associated with thrombosis risk, including D-dimer, thrombin-antithrombin complexes, fibrinogen, tissue fibrin deposition, platelet activation status and activatability, and platelet-leukocyte aggregates, were assessed. Results We generated a new line of transgenic mice that expressed 30-fold higher levels of platelet-expressed FVIII than are therapeutically required to restore hemostasis in hemophilic mice. Under both steady-state conditions and prothrombotic conditions induced by lipopolysaccharide-mediated inflammation or the FV Leiden mutation, supratherapeutic levels of platelet-expressed FVIII did not appear to be thrombogenic. Furthermore, FVIII-expressing platelets were neither hyperactivated nor hyperactivatable upon agonist activation. Conclusion We conclude that, in mice, more than 30-fold higher levels of

Importancia del Factor de Crecimiento del Endotelio Vascular (VEGF) y de sus receptores en el ciclo ovárico. Revisión

OpenAIRE

Ana María Rosales Torres; Adrián Guzmán Sánchez

2012-01-01

El objetivo de esta revisión fue recopilar y analizar la información más reciente acerca del papel del Factor de Crecimiento del Endotelio Vascular (VEGF, por sus siglas en inglés), sus receptores de membrana (VEGFR1 y VEGFR2) y receptores solubles (sVEGFR1 y sVEGFR2), durante los procesos involucrados en el ciclo ovárico. La principal función del sistema VEGF (VEGF y sus receptores), es controlar la formación de nuevos vasos sanguíneos y la protección de células endoteliales y de la granulos...

A influência das políticas de saúde nos indicadores gerados pelo sistema de informações hospitalares do SUS

OpenAIRE

Jacques Levin

2006-01-01

O uso das informações e indicadores provenientes do Sistema de Informações Hospitalares do SUS (SIH/SUS), tanto para análise de situação de saúde da população como para análise do desse, SUS, é cada vez mais frequente. Tal sistema é, desde sua concepção, fortemente influenciado pelas políticas públicas na área de atenção à saúde, como as definidas pelas Normas Operacionais e os incentivos e restrições a determinadas práticas. Alterações na operação do sistema introduzem descontinuidades e ...

Necesidades sanitarias de las personas con discapacidad intelectual y sus familias

OpenAIRE

Muñoz, J.

2005-01-01

La salud es un derecho humano fundamental. Las personas con discapacidad intelectual y sus familias afrontan una gran cantidad de barreras cuando acceden a los servicios sanitarios. La falta de acceso a estos servicios coloca a las personas con discapacidad intelectual en serias desventajas sociales. Las barreras que las personas con discapacidad intelectual encuentran en los servicios sanitarios les hacen más vulnerables a la enfermedad. Los profesionales de los hospitales y centros de salud...

Significados y respuestas de las madres al abuso sexual de sus hijas(os

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Margarita Inés Quiroz Arango

2009-01-01

Full Text Available Se presentan los resultados de una investigación dirigida a comprender los significados y las respuestas de madres frente al abuso sexual de sus hijas e hijos, para generar un conocimiento útil en la construcción de políticas y programas más pertinentes en la atención de este fenómeno. Es un estudio cualitativo que empleó como método los grupos de discusión con cinco madres de cuatro niñas y un niño, menores de 10 años, víctimas de abuso sexual, quienes asistían a consulta psicológica en dos centros de atención a la familia de la ciudad de Medellín, en el año 2005. Las voces de estas mujeres muestran que el abuso sexual sucede en familias vulnerables desde el punto de vista afectivo, comunicativo y socioeconómico, en las cuales este problema hace parte de su cotidianidad. El abuso sexual constituye una catástrofe que afecta el precario equilibrio socioeconómico y afectivo que estas familias logran construir para hacer frente a sus condiciones de vida angustiantes. En medio de la estigmatización que la sociedad hace de la situación, del silencio, con el cual soportan el trauma, y de un apoyo poco comprensivo y pertinente por parte de las instituciones encargadas de la atención de estas familias, las madres acometen diferentes acciones para hacer frente a su realidad. La reconfiguración de su rol como madres se convierte en un punto de partida clave para la superación del estado de impotencia en el cual quedan sumidas, posterior al abuso sexual de sus hijas(os.

El docente investigador: su génesis teórica y sus rasgos

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Natalia Campos Saborío

2003-01-01

Full Text Available El propósito de este artículo es enunciar los rasgos que caracterizan al docente investigador. Para ello, me ubico en el contexto teórico, desde dónde conceptualizo sus calidades, a saber: visión de mundo, de paradigma curricular, y de investigación educativa

Las relaciones especiales de sujeción entre el Estado y sus funcionarios

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Luis Eduardo Ardila Quiroz

2012-01-01

Full Text Available Este escrito hace alusión a relaciones que existe entre el Estado y sus funcionarios, desde la obediencia en Grecia, hasta la connotación que adquiere el servidor público en el Estado Social de Derecho; y a su vez, las de estos para con sus asociados, pues bien sabido es que quienes sostienen al Estado y a todo el personal necesario para la exteriorización de aquel, son quienes pagan impuestos y contribuyen para que el presupuesto de gastos en bienes y servicios lleguen a buen puerto.Así como existen obligaciones por parte del Estado, también existen deberes que cumplir por parte de quienes lo habitan, por eso es de obligatorio cumplimiento, so pena de incurrir en un delito, el pago de contribuciones a favor del Estado, pero para que las erogaciones por parte del Estado hacia su población tengan la teleología o el fin propuesto, es necesario de una buena administración, si ello no acontece, se pierde la filosofía de las buenas maneras.

Formation of ultra-fine grained TiC-dispersed SUS316L by ball-milling and their consolidation by hot isostatic pressing

International Nuclear Information System (INIS)

Zheng, Yongjia; Yamasaki, Tohru; Fukami, Takeshi; Mitamura, Tohru; Terasawa, Mititaka

2003-01-01

In order to overcome the irradiation embrittlement in austenitic stainless steels, ultra-fine grained SUS316L steels with very fine TiC particles have been developed. The SUS316-TiC nanocomposite powders having 1.0 to 2.0 mass%TiC were prepared by ball-milling SUS316-TiC powder mixtures for 125h in an argon gas atmosphere. The milled powders were consolidated by hot isostatic pressing (HIP) under a pressure of 200 MPa at temperature between 700-1000degC, and the bulk materials with crystallite size ranging between 100-400 nm have been produced. The possibility of using fine-grained TiC particles for pinning grain boundaries and thereby to maintain the ultra-fine grained structures has been discussed. (author)

¿Colombia tiene recursos económicos suficientes para atacar el narcotráfico y sus actividades vinculadas?

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Juan Felipe Jiménez Trucco

2010-11-01

Full Text Available Colombia es criticada permanentemente por la comunidad internacional en lo referente a su lucha contra la violencia. Sin embargo, no encuentra un apoyo real en algunos de sus vecinos (Nicaragua, Ecuador y Venezuela y otros actores en el ataque a generadores de violencia como son la guerrilla o los paramilitares, los cuales están a su vez relacionados con el narcotráfico. Es necesario que la comunidad internacional conozca el verdadero esfuerzo que realiza Colombia en la lucha contra el narcotráfico y la violencia asociada a este delito. Colombia ha incrementado considerablemente sus gastos en seguridad y defensa en la última década haciendo grandes esfuerzos para atacar, entre otros, el narcotráfico. Realmente ha encontrado un apoyo de sus vecinos y aliados para combatir idóneamente este delito? Con este escrito se evalúa la cooperación obtenida por Colombia por parte de otros actores en la lucha contra el narcotráfico, no solo en términos monetarios, sino también en términos de apoyo institucional.

The economic valuation of the recreational benefits of Dichato Beach (tome-Chlie)

OpenAIRE

Sergio Alonso Orrego; Arcadio Cerda; Felipe Vásquez

1997-01-01

Las condiciones naturales y la infraestructura de servicios existente en la playa de Dichato (VIII Región-Chile), posibilitan la presencia de un considerable número de familias durante las temporadas de verano. Mediante la adecuada aplicación del método del costo de viaje, es posible estimar la demanda recreacional de la playa y sus beneficios económicos. El documento privilegia la modelación del número de viajes efectuados durante un período de tiempo determinado, y en este sentido presenta ...

Estado de la gestión con enfoque de RSE de las empresas del sector hotelero en la Región Piura

OpenAIRE

Fernández Flores, Raúl Maximiliano; Franco Seminario, Miguel; Rubio Ly, Raúl Martín; Salazar Gutiérrez, Silvia Liliana

2016-01-01

viii, 132 h. : il. ; 30 cm El objetivo de este estudio es conocer el estado de la gestión con enfoque de responsabilidad social empresarial (RSE) en las empresas hoteleras de la región Piura en el año 2015, utilizando como herramienta de evaluación el cuestionario de indicadores Ethos- Perú 2021. En la actualidad, en Perú y Latinoamérica, son pocos los hoteles que implementan la responsabilidad social en sus modelos de gestión, por lo que el presente estudio es un medio que ...

A systematic review of the process of regionalization of Brazil's Unified Health System, SUS.

Science.gov (United States)

Mello, Guilherme Arantes; Pereira, Ana Paula Chancharulo de Morais; Uchimura, Liza Yurie Teruya; Iozzi, Fabíola Lana; Demarzo, Marcelo Marcos Piva; Viana, Ana Luiza d'Ávila

2017-04-01

This review focuses only on specific studies into the SUS regionalization process, which were based on empirical results and published since 2006, when the SUS was already under the aegis of the Pact for Health framework. It was found that the regionalization process is now underway in all spheres of government, subject to a set of challenges common to the different realities of the country. These include, primarily, that committee-structured entities are valued as spaces for innovation, yet also strive to overcome the bureaucratic and clientelist political culture. Regional governance is further hampered by the fragmentation of the system and, in particular, by the historical deficiency in planning, from the local level to the strategic policies for technology incorporation. The analyses enabled the identification of a culture of broad privilege for political negotiation, to the detriment of planning, as one of the main factors responsible for a vicious circle that sustains technical deficiency in management.

The Unified Health System (SUS as a large technological system: territory, technique and politic

Directory of Open Access Journals (Sweden)

Luis Henrique Leandro Ribeiro

2018-03-01

Full Text Available The Uni ed Health System (SUS constitutes a large technological system wi- thin the Brazilian territory since it aggregates a broad and diverse materiality in organizing and managing its ows. Additionally, it has two other attributes that make it unique: high sensibility to speci cities of different places; and technical and political centralization and decentralization of its actions. The macro dimen- sion is the SUS, leading it to be understood not simply as a health system, through its: multidimensionality – elements of other life instances (social, economic, cul- tural and political; broad and unequal spectrum of actors (state and non-state who move it and the meanings of its actions; and the trans-scaleness of its con- cretion in places (local, national and international nexuses. As an infrastructure of everyday life, it is a hegemonic large technological system that acts upon objec- tive (technosphere and subjective (psychosphere conditions of existence, a con- ception that has important implications for health policy and territory integration.

Tres décadas de creatividad femenina en las artes plásticas de Nicaragua y sus logros estéticos

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Gloria Escobar Soriano

2001-02-01

Full Text Available En el panorama de las artes plásticas siempre ha estado presente, y en forma beligerante, la actividad femenina. El siglo XX será recordado como el momento en que las mujeres consiguieron con sus luchas recuperar sus espacios usurpados por el monopolio masculino. Las mujeres han logrado emanciparse en el campo cultural y económico, sobre todo en los países desarrollados. Este ensayo pretende abordar la participación de la mujer nicaragüense en las artes plásticas y demostrar su papel fundamental en la creación artística. Se ha seleccionado a tres artistas contemporáneas: Ilse Ortiz, María Gallo y Patricia Bel li, con algunas de sus obras representativas, las cuales reflejan su gran contenido estético y portadoras de significado, pero con diferencias estilísticas muy particulares, en el uso de técnicas, materiales y la visión temática. Las artistas con sus metáforas visuales tratan de encontrar una conciliación más fraterna e igualitaria entre mujeres y hombres.

Percepción de las madres del estado nutricional de sus niños en una escuela primaria de Cachi (Salta, Argentina

Directory of Open Access Journals (Sweden)

Giordano Sergio A.

2013-01-01

Full Text Available Introducción: La prevalencia de sobrepeso y obesidad en la infancia ha aumentado en estas últimas décadas. La percepción distorsionada de las madres sobre la imagen corporal y los hábitos alimentarios de sus hijos son predictores de sobrepeso y obesidad. Los objetivos de este  trabajo fueron determinar la percepción materna del estado nutricional de sus hijos y compararlo con el estado nutricional evaluado. Material y Métodos: Se realizó un estudio cuantitativo, descriptivo, de corte transversal a 35 madres y sus respectivos hijos que asisten al primer grado de la escuela Victorino de la Plaza  en la localidad de Cachi. Las variables fueron edad, sexo, estado nutricional, circunferencia de cintura, percepción materna del estado nutricional de sus hijos, opinión sobre el estado  nutricional y percepción  materna de la  salud en relación con el estado nutricional. Resultados: se pudo observar que el estado nutricional de los 35 niños fue 63% normopeso,  11% bajo peso; 20% sobrepeso, y el 6% obesidad. La alteración de la percepción materna del estado nutricional fue significativamente mayor en los  niños con exceso de peso. Discusión: Las madres de hijos con sobrepeso y obesidad presentan una distorsión de la imagen corporal de sus niños, en un predominio mayor que las que se presentan en niños con normopeso. Se resalta la importancia del diagnóstico precoz de sobrepeso en niños y la necesidad de su reconocimiento por parte de sus madres.

Synthesis of methyl acetate from dimethyl ether using group VIII metal salts of phosphotungstic acid

Energy Technology Data Exchange (ETDEWEB)

Sardesai, A.; Lee, S.; Tartamella, T.

2002-04-01

Dimethyl ether (DME) can be produced much more efficiently in a single-stage, liquid-phase process from natural gas-based syngas as compared to the conventional process via dehydration of methanol. This process, based on dual catalysts slurried in inert oil, alleviates the chemical equilibrium limitation governing the methanol synthesis reaction and concurrently improves per-pass syngas conversion and reactor productivity. The potential, therefore, for production of methyl acetate via dimethyl ether carbonylation is of industrial importance. In the present study, conversion of dimethyl ether and carbon monoxide to methyl acetate is investigated over a variety of group VIII metal-substituted phosphotungstic acid salts. Experimental results of this catalytic reaction using rhodium, iridium, ruthenium, and palladium catalysts are evaluated and compared in terms of selectivity toward methyl acetate. The effects of active metal, support types, multiple metal loading, and feed conditions on carbonylation activity of DME are examined. Iridium metal substituted phosphotungstic acid supported on Davisil type 643 (pore size 150 A, surface area 279 m{sup 2}/g, mesh size 230-425) silica gel shows the highest activity for DME carbonylation. (author)

Martensitic transformation in SUS304 steels with the same Ni equivalent

International Nuclear Information System (INIS)

Ueda, T.; Okino, Y.; Takahashi, S.; Echigoya, J.; Kamada, Y.

2003-01-01

The behavior of martensitic transformation due to plastic deformation at room temperature was investigated in SUS304 austenitic stainless steels with the same nickel equivalent. The absolute volume of the martensitic phase was obtained by saturation magnetization. We discuss the shapes of the martensitic phase caused by different values of coercive force. Martensitic transformation depends on the applied stress but is independent of nickel content with same nickel equivalent. We investigated applications to nondestructive testing on the basis of the present study. (author)

VIII Spanish meeting on statistical physics: Proceeding of the Meeting held at Universidad Carlos III de Madrid

International Nuclear Information System (INIS)

Cuesta, J.A.; Sanchez, A.

1998-01-01

This book contains the Proceedings of ''Fisica Estadistica'97'' (FisEs'97, VIII Spanish Meeting on Statistical Physics), held at the Campus of Getafe (Madrid, Spain) of the Universidad Carlos III de Madrid on September 25 through 27, 1997. Although this is the first time the Proceedings of a Meeting in this series are published, ''Fisica Estasdistica'' dates back to 1986, when about fifty Spanish scientists attended the first edition in Barcelona. That first Meeting was organized by a group of young and not so young physicists who wanted to set up a national conference of an international level and with a broader, more interdisciplinary scope than others held at that time. Their idea quickly got off the ground and following the first edition, sequels took place every year and a half: Palma de Mallorca (1988), Badajoz (1990), Cabuenas, Asturies (1991), El Escorial, Madrid (1993), Sevilla (1994), and Zaragoza (1996)

Thrombomodulin as a marker for vascular tumors. Comparative study with factor VIII and Ulex europaeus I lectin.

Science.gov (United States)

Yonezawa, S; Maruyama, I; Sakae, K; Igata, A; Majerus, P W; Sato, E

1987-10-01

Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. Various vascular tumors were characterized with immunoperoxidase staining with the use of a polyclonal anti-TM serum. The staining patterns of TM were compared with those of Factor VIII-related antigen (FVIII-RAG) and Ulex europaeus agglutinin-I (UEA-I), which have been used as markers for endothelial cells. The results showed that TM is a specific and a highly sensitive marker for angiosarcomas in comparison with FVIII-RAG or UEA-I. In contrast, UEA-I is more sensitive for benign vascular tumors than TM or FVIII-RAG. The other mesenchymal tumors of nonvascular origin showed negative staining for three endothelial markers. These results indicate that TM is a new specific and sensitive tool for the diagnosis of angiosarcomas.

Diferença de Classe no SUS é inconstitucional!

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Alethele de Oliveira Santos

2015-12-01

Full Text Available A discussão sobre a ‘diferença de classe’ decorre do Recurso Extraordinário (RE 581488 interposto pelo Conselho Regional de Medicina do Rio Grande do Sul (Cremers em face da decisão do Tribunal Regional Federal da 4ªRegião (TRF –4ª, em favor do município de Canela (RS (1 junto ao Supremo Tribunal Federal (STF, com repercussão geral  reconhecida sob o número 579. Trata-se da possibilidade de que paciente do Sistema Único de Saúde (SUS pague valor financeiro por hotelaria diferenciada, ou ainda, médico de sua preferência.

The precipitation behavior of titanium carbide on the surface of SUS 321 stainless steel

International Nuclear Information System (INIS)

Yoshihara, Kazuhiro; Nii, Kazuyoshi

1982-01-01

The surface composition of SUS 321 stainless steel at high temperatures was observed in vacuum with Auger electron spectroscopy. The precipitation of titanium carbide was found on the surface of SUS 321. The thickness of precipitated titanium carbide layer increased in proportion to the square root of annealing time and became about 0.05 μm after heated at 1100 K for 432 ks. The precipitated titanium carbide was not replaced by the most surface active element sulfur, and remained stable on the surface. The precipitated layer, however, was not even and had many holes about 1 μm in diameter. The bottom of a hole was SUS 321, on which phosphorus, oxygen and sulfur segregated. As the annealing time was prolonged, these segregants were replaced one by one in the order of the surface activity, and finally the most surface active element, sulfur, remained on the bottom of the hole. Moreover, sulfur diffused over the outside of the hole. The precipitation of titanium carbide on the surface occurred according to the following processes: (1) The titanium and carbon which had been dissolved in the bulk diffused onto the surface of the stainless steel. (2) The titanium carbide which had been precipitated in the bulk dissolved because the concentration of titanum and carbon fell under their solubility limits in the bulk. (3) The titanium and carbon diffused onto the surface which was exposed to vacuum. (4) The titanium and carbon recombined into titanium carbide and precipitated on the surface. The growth rate of the thickness of the precipitated layer was controlled by the diffusion of titanium and carbon in the precipitated titanium carbide. (J.P.N.)

Development and evaluation of SUS 304H — IN 617 welds for advanced ultra supercritical boiler applications

International Nuclear Information System (INIS)

Pavan, A.H.V.; Vikrant, K.S.N.; Ravibharath, R.; Singh, Kulvir

2015-01-01

At moderately high temperature sections of Advanced Ultra Super Critical (AUSC) boilers, welding of superalloys to austenitic steels is inevitable owing to economic aspects of boiler. Welding of SUS 304H and Inconel 617 (IN 617) was attempted using IN 617 filler material employing conventional Gas Tungsten Arc Welding (GTAW) process and the procedure was successfully established along with optimized welding parameters. Microstructural characterization was carried out to identify various zones on either side of the fusion boundaries. Unmixed Zone and Heat Affected Zone (HAZ) were observed towards SUS 304H fusion boundary while no distinct HAZ was observed towards IN 617 fusion boundary. Micro-hardness profiling indicated decrease in hardness at the HAZ towards SUS 304H fusion boundary. Mechanical properties evaluation at both ambient and elevated temperatures was carried out and data obtained was compared with those of base metals. The tensile strength of the cross weld specimens at high temperatures were observed to be marginally lower than that of IN 617 but significantly more than that of SUS 304H, hence, tolerable. Stress-rupture properties of the cross-weld specimens as tested in this study were found to be intermediate to the base metals’ data, thus, suitable for AUSC power plants' boiler applications. Hence, this work gives an insight into welding procedure establishment, microstructural development, variation of mechanical properties at elevated temperatures and stress-rupture properties of the dissimilar metal welds at elevated temperatures. - Highlights: • Procedure establishment & parameters optimization for fabricating defect-free welds. • Characterization of various zones formed during welding. • Mechanical properties evaluation and comparison with those of base metals. • Influence of various zones formed during welding on mechanical properties inferred. • Understanding long term behavior of welds at elevated temperatures

Development and evaluation of SUS 304H — IN 617 welds for advanced ultra supercritical boiler applications

Energy Technology Data Exchange (ETDEWEB)

Pavan, A.H.V., E-mail: pavanahv@bhelrnd.co.in [Metallurgy Department, Corporate R& D Division, Bharat Heavy Electricals Limited, Vikasnagar, Hyderabad 500 093 (India); Vikrant, K.S.N., E-mail: vikrant@bhelrnd.co.in [Metallurgy Department, Corporate R& D Division, Bharat Heavy Electricals Limited, Vikasnagar, Hyderabad 500 093 (India); Ravibharath, R., E-mail: rrbharath@bhelrnd.co.in [Welding Research Institute, Bharat Heavy Electricals Limited, Tiruchirapalli 620 014 (India); Singh, Kulvir, E-mail: kulvir@bhelrnd.co.in [Metallurgy Department, Corporate R& D Division, Bharat Heavy Electricals Limited, Vikasnagar, Hyderabad 500 093 (India)

2015-08-26

At moderately high temperature sections of Advanced Ultra Super Critical (AUSC) boilers, welding of superalloys to austenitic steels is inevitable owing to economic aspects of boiler. Welding of SUS 304H and Inconel 617 (IN 617) was attempted using IN 617 filler material employing conventional Gas Tungsten Arc Welding (GTAW) process and the procedure was successfully established along with optimized welding parameters. Microstructural characterization was carried out to identify various zones on either side of the fusion boundaries. Unmixed Zone and Heat Affected Zone (HAZ) were observed towards SUS 304H fusion boundary while no distinct HAZ was observed towards IN 617 fusion boundary. Micro-hardness profiling indicated decrease in hardness at the HAZ towards SUS 304H fusion boundary. Mechanical properties evaluation at both ambient and elevated temperatures was carried out and data obtained was compared with those of base metals. The tensile strength of the cross weld specimens at high temperatures were observed to be marginally lower than that of IN 617 but significantly more than that of SUS 304H, hence, tolerable. Stress-rupture properties of the cross-weld specimens as tested in this study were found to be intermediate to the base metals’ data, thus, suitable for AUSC power plants' boiler applications. Hence, this work gives an insight into welding procedure establishment, microstructural development, variation of mechanical properties at elevated temperatures and stress-rupture properties of the dissimilar metal welds at elevated temperatures. - Highlights: • Procedure establishment & parameters optimization for fabricating defect-free welds. • Characterization of various zones formed during welding. • Mechanical properties evaluation and comparison with those of base metals. • Influence of various zones formed during welding on mechanical properties inferred. • Understanding long term behavior of welds at elevated temperatures.

Experiencias de reconocimiento vividas por los niños en sus familias

Directory of Open Access Journals (Sweden)

Magda Victoria Díaz Alzate

2015-07-01

Full Text Available Pretendemos establecer una relación entre la propuesta que hace Axel Honneth sobre el reconocimiento en el amor y las prácticas de crianza vividas por los integrantes de la familia, en especial entre los niños y las personas cuidadoras, para argumentar que en estas relaciones se da comienzo a la configuración de los niños como sujetos políticos. Para Honneth –quien retoma a Hegel y a Mead–, las primeras relaciones amorosas son sustanciales para vivir el reconocimiento afectivo –que se vive con los más íntimos–; en ellas la aceptación emocional va unida a sentimientos como la simpatía y la atracción, y les permite visibilizar al otro a partir de sus necesidades propias y su valor humano. Abordaremos la familia como primera estructura de acogida y primer escenario de socialización, para argumentar que los niños viven en sus familias, prácticas de reconocimiento de sí mismos, de los otros y del mundo que les rodea, lo cual, a nuestro modo de ver, hace parte de su proceso de socialización como sujetos políticos.

Joint bleeds increase the inhibitor response to human factor VIII in a rat model of severe haemophilia A

DEFF Research Database (Denmark)

Löfgren, Karin Maria; Søndergaard, H.; Skov, Søren

2016-01-01

Introduction The most serious complication in haemophilia A (HA) replacement therapy with coagulation factor VIII (FVIII) is neutralizing antibodies, i.e. inhibitors. It has been hypothesized that danger signals generated during a bleed might have an adjuvant effect on the immune response to FVIII...... in on-demand treatment, increasing the inhibitor risk. Aim To compare the antibody response to treatment with recombinant human FVIII (rhFVIII) in relation to induced knee joint bleeds and treatment without concurrent bleeds in a HA rat model. Method HA rats were divided into two groups: one group (n...... = 10) receiving three needle induced knee joint bleeds 14 days apart and a control group (n = 9) receiving three sham procedures. Three hours after each injury/sham 50 IU kg−1 rhFVIII was administrated intravenously. Subsequently, both groups continued rhFVIII treatment for another 9 weeks. Binding...

Diferença de Classe no SUS: Discursos favoráveis em audiência pública no STF em 2014.

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Mayara Mota Martins

2015-12-01

Full Text Available Diante do pedido do Conselho Regional de Medicina do Estado do Rio Grande do Sul, que demanda a instituição da chamada ‘Diferença de classe no SUS’, o Supremo Tribunal Federal convocou audiência pública para a oitiva de especialistas e pessoas com experiência na área da saúde a fim de subsidiar a decisão desta corte. A diferença de classe consiste na melhoria de acomodação recebida pelo usuário no caso da sua internação, e a contratação do profissional médico de sua preferência mediante o pagamento da respectiva diferença. Este trabalho tem como objetivo analisar os argumentos favoráveis à diferença de classe no SUS proferidos na audiência pública ‘Internação Hospitalar com diferença de classe no SUS’ realizada no dia 26 de maio de 2014 no STF, e fazer uma reflexão sobre de que forma essa medida poderia impactar o SUS frente aos seus princípios e diretrizes, por meio da análise de discurso. Verificou-se que a diferença de classe se mostra incompatível com o SUS, já que este tem como diretrizes a igualdade e universalidade do atendimento sem privilégios de qualquer espécie. Ademais, a instituição da diferença de classe no SUS não somente fere a legislação brasileira, como representa um retrocesso no que tange os direitos sociais. Com esse entendimento a Suprema Corte aboliu a diferença de classe julgando favoravelmente ao SUS.

Budget Management Health System Only - SUS im Municipal Context: Analysis of Audit-SUS in PPA of Fortaleza and its Role in Social Control Strengthening

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Lizziane Souza Queiroz Franco de Oliveira

2016-10-01

Full Text Available The budget planning is the duty of every manager and fundamental for the implementation of key policies such as health. To implement them, it’s necessary to control the provision of these services; hence the importance of the audit. This article intends to, through documentary and bibliographic research, analyzing quantitative and qulitatively budgetary forecasting and execution aimed at audit’s actions - SUS, provideds for PPA/2014-2017 and LOA-2014, both the city of Fortaleza, in order to ascertain whether the municipal management performs its expenditure aimed at encouraging good planning and provide to society an efficient public management and responsive to social control.

High prevalence of co-infection with multiple Torque teno sus virus species in Italian pig herds.

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Sylvain Blois

Full Text Available Torque teno viruses (TTVs are a large group of vertebrate-infecting small viruses with circular single-stranded DNA, classified in the Anelloviridae family. In swine, two genetically distinct species, Torque teno sus virus 1a (TTSuV1a and 1b (TTSuV1b are currently grouped into the genus Iotatorquevirus. More recently, a novel Torque teno sus virus species, named Torque teno sus virus k2b (TTSuVk2b, has been included with Torque teno sus virus k2a (TTSuVk2a into the genus Kappatorquevirus. In the present study, TTSuV1 (TTSuV1a and TTSuV1b, TTSuVk2a and TTSuVk2b prevalence was evaluated in 721 serum samples of healthy pigs from Sardinian farms, insular Italy. This is the largest study to date on the presence of TTSuV in healthy pigs in Italy. The global prevalence of infection was 83.2% (600/721, being 62.3% (449/721, 60.6% (437/721, and 11.5% (83/721 the prevalence of TTSuV1, TTSuVk2a and TTSuVk2b, respectively. The rate of co-infection with two and/or three species was also calculated, and data show that co-infections were significantly more frequent than infections with single species, and that TTSuV1+TTSuVk2a double infection was the prevalent combination (35.4%. Quantitative results obtained using species-specific real time-qPCR evidenced the highest mean levels of viremia in the TTSuV1 subgroup, and the lowest in the TTSuVk2b subgroup. Interestingly, multiple infections with distinct TTSuV species seemed to significantly affect the DNA load and specifically, data highlighted that double infection with TTSuVk2a increased the viral titers of TTSuV1, likewise the co-infection with TTSuVk2b increased the titers of TTSuVk2a.

High prevalence of co-infection with multiple Torque teno sus virus species in Italian pig herds.

Science.gov (United States)

Blois, Sylvain; Mallus, Francesca; Liciardi, Manuele; Pilo, Cristian; Camboni, Tania; Macera, Lisa; Maggi, Fabrizio; Manzin, Aldo

2014-01-01

Torque teno viruses (TTVs) are a large group of vertebrate-infecting small viruses with circular single-stranded DNA, classified in the Anelloviridae family. In swine, two genetically distinct species, Torque teno sus virus 1a (TTSuV1a) and 1b (TTSuV1b) are currently grouped into the genus Iotatorquevirus. More recently, a novel Torque teno sus virus species, named Torque teno sus virus k2b (TTSuVk2b), has been included with Torque teno sus virus k2a (TTSuVk2a) into the genus Kappatorquevirus. In the present study, TTSuV1 (TTSuV1a and TTSuV1b), TTSuVk2a and TTSuVk2b prevalence was evaluated in 721 serum samples of healthy pigs from Sardinian farms, insular Italy. This is the largest study to date on the presence of TTSuV in healthy pigs in Italy. The global prevalence of infection was 83.2% (600/721), being 62.3% (449/721), 60.6% (437/721), and 11.5% (83/721) the prevalence of TTSuV1, TTSuVk2a and TTSuVk2b, respectively. The rate of co-infection with two and/or three species was also calculated, and data show that co-infections were significantly more frequent than infections with single species, and that TTSuV1+TTSuVk2a double infection was the prevalent combination (35.4%). Quantitative results obtained using species-specific real time-qPCR evidenced the highest mean levels of viremia in the TTSuV1 subgroup, and the lowest in the TTSuVk2b subgroup. Interestingly, multiple infections with distinct TTSuV species seemed to significantly affect the DNA load and specifically, data highlighted that double infection with TTSuVk2a increased the viral titers of TTSuV1, likewise the co-infection with TTSuVk2b increased the titers of TTSuVk2a.

PENINGKATKAN KEAKTIFAN DAN HASIL BELAJAR SISWA KELAS VIII PADA MATERI SISTEM PERSAMAAN LINEAR DUA VARIABEL DENGAN PEMBELAJARAN KOOPERATIF TGT

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Wawan Suseno

2017-10-01

Berdasarkan pengalaman mengajar di SMPN 01 Bang Haji, ternyata masih banyak yang mengalami kesulitan dalam memahami persamaan linear dua variabel. Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa dan keaktifan siswa belajar di dalam kelas. Jenis penelitian ini adalah penelitian tindakan kelas (PTK dengan dua siklus, siklus I terdiri atas 9 pertemuan, dan siklus II 6 pertemuan. Subjek penelitian adalah 24 orang siswa kelas VIII, 6 orang laki-laki, dan 18 orang perempuan. Kegiatan penelitian pada tanggal 16 Januari sampai 17 Maret 2017. Kegiatan pembelajaran dengan menerapkan pembelajaran kooperatif tipe TGT. Hasil penelitian menunjukkan bahwa penerapan pembelajaran kooperatif tipe TGT telah terlaksana dengan sangat baik, keaktifan belajar siswa yang diperoleh dari hasil observasi dan angket berada pada kategori tinggi dan baik, hasil belajar siswa mencapai 87,5 % dan telah mencapai nilai ≥ 70.

Las bandas de "Huaso Raimundo". Redes sociales y transicionalidad delictiva en Santiago y sus alrededores, 1882-1911.

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Ignacio Ayala Cordero

2012-08-01

Full Text Available En su calidad de ladrón conocido, Nonato Orellana Avilés aparece como un sujeto transicional en el contexto de la modernización capitalista en Chile. Representa el proceso de descampesinización y la pretensión de disciplinamiento del peonaje rural, además de las formas de incorporación al mundo urbano desde la transgresión. Expresión de transicionalidad también es la diversidad de soportes documentales de los delitos que lo tuvieron por protagonista en un espacio de tiempo que se extiende desde 1904 hasta 1911. El objetivo de este artículo es analizar –incorporandola aproximación microhistórica y el análisis de redes sociales– la práctica criminal desarrollada por las bandas del “Huaso Raimundo”, a partir de sus dimensiones estratégica y organizacional. En tanto estrategia de supervivencia al día, sin subordinarse a la ética del trabajo, constituiría una alternativa a la proletarización; mientras que a través de sus formas organizativas características, tal estrategia se proyectaría socialmente incorporándose en el proceso deconfiguración de los “bajos fondos” de Santiago y sus alrededores.

Cacotheline as an oxidimetric reagent. Determination of Sn(II), Cu(I), Ti(III), Fe(II), V(II) and V(III)

International Nuclear Information System (INIS)

Nemani Murty, K.; Yedluri Rao, P.; Geddada Chalam, K.

1982-01-01

Sn(II), Ti(III), Cu(I),Fe(II), V(III) and V(II) can be titrated potentiometrically with cacotheline in 1-4 M hydrochloric acid, 0.5-2 M hydrochloric acid, 0.5-1.5 M sulphuric acid in presence of 4 ml of 10% EDTA solution in a total volume of 50 ml, 9-10 M phosphoric acid, 4-8 M acetic acid and 3-8 M acetic acid respectively. Cacotheline can be used for the assay of tin plate and solder. The cacotheline undergoes a 2-electron reduction reaction. A cacotheline solution (0.005 M) in 0.02 M hydrochloric acid is fairly stable for several months. The conditional redox potentials of cacotheline have been determined in sulphuric, phosphoric and acetic acid medium. (Author)

Moessbauer spectroscopy of He irradiated austenitic stainless steel SUS304 at low temperature

Energy Technology Data Exchange (ETDEWEB)

Horii, Kiyomasa; Ishibashi, Tetsu; Toriyama, Tamotsu; Wakabayashi, Hidehiko; Iijima, Hiroshi [Musashi Inst. of Tech., Tokyo (Japan); Kawasaki, Katsunori; Hayashi, Nobuyuki; Sakamoto, Isao

1996-04-01

SUS 304 austenitic stainless steel causes the magnetic transition at 60 K, and the Young`s modulus lowers. In addition, its composition elements have the large (n,{alpha}) reaction cross section to high energy neutrons, and helium is apt to be generated, and this is a factor that lowers the material strength. In the He-irradiated parts in austenitic stainless steel, the precursory state of martensite transformation should exist, and its effect is considered to be observable by carrying out low temperature Moessbauer spectroscopy. As to the preparation of He-irradiation samples, the SUS 304 foils used and the irradiation conditions are described. The measurement of low temperature Moessbauer spectra for the samples without irradiation and with irradiation is reported. In order to determine the magnetic transition point, the thermal scanning measurement was carried out for the samples without or with irradiation. The martensite transformation was measured by X-ray diffraction and transmission type Moessbauer spectroscopy. In order to observe the state of the sample surfaces, the measurement by internal conversion electron Moessbauer spectroscopy was performed. These results and the temperature dependence of the Moessbauer spectra for the irradiated parts are reported. (K.I.)

Moessbauer spectroscopy of He irradiated austenitic stainless steel SUS304 at low temperature

International Nuclear Information System (INIS)

Horii, Kiyomasa; Ishibashi, Tetsu; Toriyama, Tamotsu; Wakabayashi, Hidehiko; Iijima, Hiroshi; Kawasaki, Katsunori; Hayashi, Nobuyuki; Sakamoto, Isao.

1996-01-01

SUS 304 austenitic stainless steel causes the magnetic transition at 60 K, and the Young's modulus lowers. In addition, its composition elements have the large (n,α) reaction cross section to high energy neutrons, and helium is apt to be generated, and this is a factor that lowers the material strength. In the He-irradiated parts in austenitic stainless steel, the precursory state of martensite transformation should exist, and its effect is considered to be observable by carrying out low temperature Moessbauer spectroscopy. As to the preparation of He-irradiation samples, the SUS 304 foils used and the irradiation conditions are described. The measurement of low temperature Moessbauer spectra for the samples without irradiation and with irradiation is reported. In order to determine the magnetic transition point, the thermal scanning measurement was carried out for the samples without or with irradiation. The martensite transformation was measured by X-ray diffraction and transmission type Moessbauer spectroscopy. In order to observe the state of the sample surfaces, the measurement by internal conversion electron Moessbauer spectroscopy was performed. These results and the temperature dependence of the Moessbauer spectra for the irradiated parts are reported. (K.I.)

Estrés agudo en niños intervenidos quirúrgcamente y sintomatología en sus progenitores

OpenAIRE

Fuster Navarro, Desamparados

2013-01-01

La intervención quirúrgica (IQ) en la infancia representa un estrés potencial para el niño y sus familiares. La ansiedad es una de las reacciones más frecuentes. Respecto al estrés, existe una transmisión de emociones entre los progenitores y el niño IQ (intervenido quirúrgicamente). Es difícil separar los efectos de la hospitalización y sus consecuencias de las experiencias traumáticas de los niños IQ y su familia por lo que el estrés se ha investigado en relación al desarrollo psicosocial ...

Political Obstacles to Regionalization of the SUS: perceptions of Municipal Health Secretaries with seat in the Bipartite Interagency Commissions.

Science.gov (United States)

Moreira, Marcelo Rasga; Ribeiro, José Mendes; Ouverney, Assis Mafort

2017-04-01

This paper aims to identify and analyze the political obstacles to the implementation of Organizational Contract of Public Action (COAP) based on the perceptions of municipal health secretaries of Bipartite Interagency Commissions (CIB). For this purpose, we interviewed 195 secretaries (92% of the total) from October 2015 to August 2016. Based on the approach of policy analysis, the main hurdles identified were, in short, a traditional obstacle (lack of resources), one that has been gaining strength in recent years (judicialization of politics) and another, perhaps unheard of: the party-political system and the State Executive Branch are the great absentees in the coalitions in support of SUS regionalization policies. We can conclude that such obstacles indicate an extremely negative setting for the implementation of the COAP and other SUS regionalization policies. Thus, it is incumbent upon those involved to reflect, negotiate and build consensus on improving the health of the population and overcome such obstacles if, of course, they embrace the authors' concept that regionalization is fundamental for the SUS.

The role of dentists in the Unified Health System (SUS)

OpenAIRE

Aerts, Denise; Abegg, Claídes; Cesa, Kátia

2004-01-01

O Sistema Único de Saúde é um processo social em construção permanente, sendo fundamental a contínua discussão sobre seu modelo de atenção, os paradigmas explicativos do processo saúde-doença que o embasam e o papel de diferentes profissionais que nele atuam. Esse trabalho objetiva a discussão sobre a atuação do cirurgião-dentista no SUS. Uma forma de sistematizar suas possibilidades de atuação é a sua inserção no sistema. Em nível central ou distrital, deve atuar em equipes interdisciplinare...

La escuela de sistemas y sus aplicaciones a la administración.

OpenAIRE

2013-01-01

El artículo hace de forma general una caracterización de la Escuela de Sistemas, iniciando con una aproximación conceptual, pasando por una clasificación de los distintos sistemas, sus niveles de desarrollo y presentando una rápida relación entre la teoría de sistemas y la administración, su aplicación, describiendo a manera de ejemplo un modelo referente a una pequeña empresa panificadora.

ANALISIS MAQÂṢID ASY-SYARÎ’AH TERHADAP PUTUSAN MK NOMOR 46/PUU-VIII/2010 DAN IMPLIKASINYA TERHADAP HUKUM KELUARGA ISLAM DI INDONESIA

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Muhammad Ubayyu Rikza

2017-12-01

Full Text Available The Constitutional Court made a revolutionary decision through the decision of Constitutional Court Number 46/PUU-VIII/2010 about the status of children outside of marriage. The decision stated that childrens born outside of marriage not only had a civil relationship with their mother and mother's family but also had a civil relationship with their biological father. Its implicates that children outside of marriage have the same rights with legal children, such as  earning a living, inheritance and equality before the law. Seen from the concept of maqâṣid asy-syarî'ah, the decision does not violate the Islamic law, otherwhise it is in the line with the principles of maqâṣid asy-syarî'ah especially the principles of ḥifẓ an-nasl and ḥifẓ an-nafs.   [Mahkamah Konstitusi telah membuat putusan revolusioner dalam putusan MK Nomor 46/PUU-VIII/2010 tentang status anak di luar perkawinan. Putusan tersebut menyatakan bahwa anak yang dilahirkan di luar perkawinan mempunyai hubungan perdata dengan ibu dan keluarga ibunya dan mempunyai hubungan perdata dengan ayah biologisnya yang dibuktikan berdasarkan ilmu pengetahuan dan teknologi. Implikasinya adalah anak di luar perkawinan mendapat hak sama dengan anak sah, mendapatkan nafkah, waris dan persamaan di hadapan hukum. Dilihat dari konsep maqâṣid asy-syarî’ah, putusan tersebut tidak melanggar hukum Islam, sebaliknya, ia sejalan dengan prinsip-prinsip maqâṣid asy-syarî’ah terutama prinsip ḥifẓ an-nasl dan ḥifẓ an-nafs.

Ramsay Hunt syndrome with unilateral polyneuropathy involving cranial nerves V, VII, VIII, and XII in a diabetic patient.

Science.gov (United States)

Sun, Wei-Lian; Yan, Jian-Liang; Chen, Li-Li

2011-01-01

Ramsay Hunt syndrome is a rare complication of the varicella zoster virus, defined as a peripheral facial palsy that typically results from involvement of the facial and auditory nerves. Ramsay Hunt syndrome can be associated with cranial nerves V, VI, IX, and X but rarely with XII. We describe an atypical case of Ramsay Hunt syndrome with multiple cranial nerve involvement of nerves V, VII, VIII, and XII. Antiviral drugs, antibiotics, insulin, and traditional Chinese drugs were administered immediately after admission. After 3 months of combination therapy, the patient had recovered satisfactorily. Herpes zoster can cause severe infections in diabetic patients and should be treated as soon after detection as possible. Ramsay Hunt syndrome should be recognized as a polycranial neuritis characterized by damage to sensory and motor nerves. In addition to facial and vestibular nerve paralysis, Ramsay Hunt syndrome may also involve cranial nerves V and XII.

Manufacturing process used to produce long-acting recombinant factor VIII Fc fusion protein.

Science.gov (United States)

McCue, Justin; Kshirsagar, Rashmi; Selvitelli, Keith; Lu, Qi; Zhang, Mingxuan; Mei, Baisong; Peters, Robert; Pierce, Glenn F; Dumont, Jennifer; Raso, Stephen; Reichert, Heidi

2015-07-01

Recombinant factor VIII Fc fusion protein (rFVIIIFc) is a long-acting coagulation factor approved for the treatment of hemophilia A. Here, the rFVIIIFc manufacturing process and results of studies evaluating product quality and the capacity of the process to remove potential impurities and viruses are described. This manufacturing process utilized readily transferable and scalable unit operations and employed multi-step purification and viral clearance processing, including a novel affinity chromatography adsorbent and a 15 nm pore size virus removal nanofilter. A cell line derived from human embryonic kidney (HEK) 293H cells was used to produce rFVIIIFc. Validation studies evaluated identity, purity, activity, and safety. Process-related impurity clearance and viral clearance spiking studies demonstrate robust and reproducible removal of impurities and viruses, with total viral clearance >8-15 log10 for four model viruses (xenotropic murine leukemia virus, mice minute virus, reovirus type 3, and suid herpes virus 1). Terminal galactose-α-1,3-galactose and N-glycolylneuraminic acid, two non-human glycans, were undetectable in rFVIIIFc. Biochemical and in vitro biological analyses confirmed the purity, activity, and consistency of rFVIIIFc. In conclusion, this manufacturing process produces a highly pure product free of viruses, impurities, and non-human glycan structures, with scale capabilities to ensure a consistent and adequate supply of rFVIIIFc. Copyright © 2015 Biogen. Published by Elsevier Ltd.. All rights reserved.

Extracorporeal adsorption of anti-factor VIII allo-antibodies on randomly functionalized polystyrene resins.

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Huguet, Hélène-Céline; Lasne, Dominique; Rothschild, Chantal; Siali, Rosa; Jozefonvicz, Jacqueline

2004-02-01

The occurrence of anti-factor VIII (FVIII) allo-antibodies is a severe complication of the treatment of haemophilia A patients, leading to the inhibition of transfused FVIII activity. The effective elimination of these inhibitory antibodies plays a decisive role in the management of affected patients. To achieve this, immunoadsorption devices employing synthetic adsorbers, which selectively eliminate inhibitors, are of interest in the treatment strategy of haemophilia A patients with inhibitors. Adsorbers consisting of polystyrene-based beads substituted with sulphonate and L-tyrosyl methylester groups, which mimic part of epitope of FVIII molecule recognized by inhibitors, exhibit selective binding capacities towards anti-FVIII antibodies. The adsorption of FVIII inhibitors was investigated by simulating an extracorporeal circulation of haemophilic plasma over these functionalized resins. These innovative adsorbers are able to remove around 25% of anti-FVIII antibodies in 15 minutes depending on the plasma tested. Furthermore, they do not modify the amount of essential plasmatic proteins or residual immunoglobulins G. Experiments which were carried out using different plasmas with various inhibitor titres demonstrate a good reproducibility regarding the adsorption capacity of the synthetic resin. The characteristics of adsorption are similar on either native or regenerated resins. Both the purely synthetic nature of the resin and its easy processability demonstrate the real advantages over currently available protocols. This synthetic adsorber is a major technological advance in selective removal of FVIII inhibitory antibodies.

Ortega, psicólogo y la superación de sus maestros

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Nelson R. ORRINGER

2009-11-01

Full Text Available En noviembre de 1915, Unamuno celebró que hubiera surgido en España un interés por el examen filosófico de los problemas de la conciencia. Había asistido a «una conferencia sobre Filosofía de una serie tendiente a mostrar la diferencia entre la Psicología y la Lógica, que las da Ortega, y levanta el ánimo ver la cantidad y la calidad de los oyentes». No parece imposible que Unamuno hubiese escuchado parte del curso público de quince lecciones de psicología, dadas por Ortega en el otoño de 1915 y en el invierno de 1916. Curso cuyo texto incompleto había de salir publicado en 1982 con el título que le puso Paulino Garagorri, Investigaciones psicológicas. Garagorri reconocía la importancia del curso para aclarar la evolución filosófica de Ortega, pues en sus lecciones anunció su «superación del idealismo o subjetivismo». No sospechaba Garagorri, sin embargo, que el curso había de esclarecer además lo que entendía Ortega por el concepto de «superación ». Hasta ahora, la imposibilidad de saberlo ha hecho inciertas las relaciones de Ortega con sus fuentes idealistas.

AN XMM-NEWTON SURVEY OF THE SOFT X-RAY BACKGROUND. II. AN ALL-SKY CATALOG OF DIFFUSE O VII AND O VIII EMISSION INTENSITIES

International Nuclear Information System (INIS)

Henley, David B.; Shelton, Robin L.

2012-01-01

We present an all-sky catalog of diffuse O VII and O VIII line intensities, extracted from archival XMM-Newton observations. This catalog supersedes our previous catalog, which covered the sky between l = 120° and l = 240°. We attempted to reduce the contamination from near-Earth solar wind charge exchange (SWCX) emission by excluding times of high solar wind proton flux from the data. Without this filtering, we were able to extract measurements from 1868 observations. With this filtering, nearly half of the observations became unusable, and only 1003 observations yielded measurements. The O VII and O VIII intensities are typically ∼2-11 and ∼ –2 s –1 sr –1 (line unit, L.U.), respectively, although much brighter intensities were also recorded. Our data set includes 217 directions that have been observed multiple times by XMM-Newton. The time variation of the intensities from such directions may be used to constrain SWCX models. The O VII and O VIII intensities typically vary by ∼ 10 L.U. were observed. We compared our measurements with models of the heliospheric and geocoronal SWCX. The heliospheric SWCX intensity is expected to vary with ecliptic latitude and solar cycle. We found that the observed oxygen intensities generally decrease from solar maximum to solar minimum, both at high ecliptic latitudes (which is as expected) and at low ecliptic latitudes (which is not as expected). The geocoronal SWCX intensity is expected to depend on the solar wind proton flux incident on the Earth and on the sightline's path through the magnetosheath. The intensity variations seen in directions that have been observed multiple times are in poor agreement with the predictions of a geocoronal SWCX model. We found that the oxygen lines account for ∼40%-50% of the 3/4 keV X-ray background that is not due to unresolved active galactic nuclei, in good agreement with a previous measurement. However, we found that this fraction is not easily explainable by a

Iconoclasmo e iconodulia entre oriente y occidente (siglos VIII-IX Iconoclasm and iconoduly between east and west (8th-9th centuries

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Alfonso Hernández Rodríguez

2011-10-01

Full Text Available El siguiente artículo trata acerca de la recepción en el occidente carolingio de la crisis iconoclasta. Reflexiona sobre la forma en que ambas cristiandades trataron el problema que las imágenes representan para las prácticas religiosas y las consecuencias políticas del culto de los iconos. El escrito afirma también que durante los siglos VIII y IX la crisis iconoclasta permitió la aparición de una tradición cristiana latina consciente de sí misma. Por lo tanto, se trató del momento que puso en evidencia el nacimiento de dos formas divergentes de piedad cristiana y la alienación de una respecto de la otra. La cristiandad occidental centrada en el edificio eclesiástico y que privilegiaba la ubicación de lo sagrado en el rito eucarístico, y la oriental cuyo centro era la adoración de las imágenes, con la consecuente multiplicación de los espacios sagrados.The following paper deals with the reception in the Carolingian west of the Byzantine Iconoclast Crisis. It considers the way both Christianities dealed with the problem that images presented to religious practices and the political consequences of iconic worship. The paper also states that during the VIII and IX centuries the iconoclast crisis allowed the emergence of a self conscious Latin Christian tradition. Consequently it was the moment that showed the beginning of two differing ways of Christian piety and the alienation of one towards the other. Western Christianity focused its religion practice in church building and the idea of Sacrality in the Eucharistic Rite. The oriental church, moreovers, centered its practices and theology on icon worship.

Limit of detection and threshold for positivity of the Centers for Disease Control and Prevention assay for factor VIII inhibitors.

Science.gov (United States)

Miller, C H; Boylan, B; Shapiro, A D; Lentz, S R; Wicklund, B M

2017-10-01

Essentials Immunologic methods detect factor VIII (FVIII) antibodies in some inhibitor-negative specimens. Specimens were tested by modified Nijmegen-Bethesda assay (NBA) and fluorescence immunoassay. The NBA with preanalytical heat inactivation detects FVIII inhibitors down to 0.2 NBU. IgG 4 frequency validates the established threshold for positivity of ≥ 0.5 NBU for this NBA. Background The Bethesda assay for measurement of factor VIII inhibitors called for quantification of positive inhibitors by using dilutions producing 25-75% residual activity (RA), corresponding to 0.4-2.0 Bethesda units, with the use of 'more sensitive methods' for samples with RA closer to 100% being recommended. The Nijmegen modification (Nijmegen-Bethesda assay [NBA]) changed the reagents used but not these calculations. Some specimens negative by the NBA have been shown to have FVIII antibodies detectable with sensitive immunologic methods. Objective To examine the performance at very low inhibitor titers of the Centers for Disease Control and Prevention (CDC)-modified NBA (CDC-NBA), which includes preanalytic heat inactivation to liberate bound anti-FVIII antibodies. Methods Specimens with known inhibitors were tested with the CDC-NBA. IgG 4 anti-FVIII antibodies were measured by fluorescence immunoassay (FLI). Results Diluted inhibitors showed linearity below 0.4 Nijmegen-Bethesda units (NBU). With four statistical methods, the limit of detection of the CDC-NBA was determined to be 0.2 NBU. IgG 4 anti-FVIII antibodies, which correlate most strongly with functional inhibitors, were present at rates above the background rate of healthy controls in specimens with titers ≥ 0.2 NBU and showed an increase in frequency from 14.3% at 0.4 NBU to 67% at the established threshold for positivity of 0.5 NBU. Conclusions The CDC-NBA can detect inhibitors down to 0.2 NBU. The FLI, which is more sensitive, demonstrates anti-FVIII IgG 4 in some patients with negative (NBA, supporting the need for

La violencia en la palabra: narraciones de madres atrapadas en sus redes sociales*

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Rodríguez G, Alfonso; Rodríguez E, Gilma; Roldán R, Lucía

2007-01-01

Objetivo: Realizar un estudio descriptivo y analítico sobre los imaginarios de mujeres embarazadas en condiciones de precariedad y violencia, acerca de su percepción del embarazo y de sus redes intrafamiliares y extrafamiliares, por medio de sus narrativas. Método: Se aplicó una encuesta a 350 mujeres gestantes del programa Familia Gestante-Bebé Sano, del Departamento Administrativo de Bienestar Social de la Localidad de Usaquén, con seguimiento de un año (seis meses de gestación y seis meses...

Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects.

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Hsia, Chien-Hsun; Shen, Ming-Ching; Lin, Jen-Shiou; Wen, Yao-Ke; Hwang, Kai-Lin; Cham, Thau-Ming; Yang, Nae-Cherng

2009-03-01

Nattokinase, a serine proteinase from Bacillus subtilis, is considered to be one of the most active functional ingredients found in natto. In this study, we hypothesized that nattokinase could reduce certain factors of blood clotting and lipids that are associated with an increase risk for cardiovascular disease (CVD). Thus, an open-label, self-controlled clinical trial was conducted on subjects of the following groups: healthy volunteers (Healthy Group), patients with cardiovascular risk factors (Cardiovascular Group), and patients undergoing dialysis (Dialysis Group). All subjects ingested 2 capsules of nattokinase (2000 fibrinolysis units per capsule) daily orally for 2 months. The laboratory measurements were performed on the screening visit and, subsequently, regularly after the initiation of the study. The intent-to-treat analysis was performed on all 45 enrolled subjects. By use of mixed model analysis, a significant time effect, but not group effect, was observed in the change from baseline of fibrinogen (P = .003), factor VII (P nattokinase. No significant changes of uric acid or notable adverse events were observed in any of the subjects. In summary, this study showed that oral administration of nattokinase could be considered as a CVD nutraceutical by decreasing plasma levels of fibrinogen, factor VII, and factor VIII.

Reflections on the Production of the Formation of Physiotherapy in the Con-text of SUS

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Ana Luísa Pinho Pinto Ferreira

Full Text Available Abstract Background: This study was motivated by the need of understanding how the relationship of the training with the national health system is treated, both in the sphere of health services and the aca-demic area. This work aims to contribute to the debate on the inclusion of the physiotherapist in SUS (Brazil's NHS by pointing out issues that need to be deepened in future studies. Purpose: To analyze the national literature production on the relationship between the training of therapists and their work in SUS, from 1996 to 2010. Methods: Descriptive research with literature on the bases: LILACS, SCI-ELO Bank and CAPES thesis. Results: We found 13 publications, sorted by: year, publication type, region where it was published in the categories "national curriculum guidelines," "professional respon-sibility", "integrality in health" and "conceptions of teachers in training in Physiotherapy ". There no publishing from 1996 to 2005, gradually increasing from this year. It was identified a higher number of articles compared to other types of publications; there is also an important difference between the Brazilian regions, with higher prevalence of studies in the South (53.8% and a greater number of pub-lications in the category "national curriculum guidelines". Conclusion: It was possible to raise ques-tions that involve the applicability of the National Curriculum Guidelines on the pedagogical courses; suitability of teachers to the reality of SUS; investigation of the models covered in health care envi-ronments trainers, and the lack of contribution by higher education institutions on teaching-research and teaching and public service, contributing to form an important agenda of study. {#}

Las pedagogías críticas: un lenguaje de la posibilidad para la universidad y sus maestros

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Piedad Ramírez-Pardo

2012-01-01

Full Text Available El ensayo destaca los aportes de las pedagogías críticas para repensar el papel de la universidad y sus maestros en la sociedad. Reivindica la autonomía, la crítica, la libertad académica y la recuperación del maestro como intelectual transformativo, con capacidad para pensar la sociedad y construir un discurso que conjugue el lenguaje de la crítica con el de la posibilidad; maestros que se perciban a sí mismos con capacidad y opciones para enfrentar constructivamente la complejidad del mundo social y potenciar desde su rol, con sus estudiantes la transformación del orden establecido.

La escuela de sistemas y sus aplicaciones en la administración

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Carlos Ramírez Cardona

1989-01-01

RESUMEN El artículo hace de forma general una caracterización  de la Escuela de Sistemas, iniciando con una aproximación conceptual, pasando por una clasificación de los distintos sistemas, sus niveles de desarrollo y presentando una rápida relación entre la teoría  de sistemas y la administración, su aplicación, describiendo a manera de ejemplo un modelo referente a una pequeña empresa panificadora.

AN XMM-NEWTON SURVEY OF THE SOFT X-RAY BACKGROUND. I. THE O VII AND O VIII LINES BETWEEN l = 120 DEG. AND l = 240 DEG

International Nuclear Information System (INIS)

Henley, David B.; Shelton, Robin L.

2010-01-01

We present measurements of the soft X-ray background (SXRB) O VII and O VIII intensity between l = 120 deg. and l = 240 deg., the first results of a survey of the SXRB using archival XMM-Newton observations. We do not restrict ourselves to blank-sky observations, but instead use as many observations as possible, removing bright or extended sources by hand if necessary. In an attempt to minimize contamination from near-Earth solar wind charge exchange (SWCX) emission, we remove times of high solar wind proton flux from the data. Without this filtering we are able to extract measurements from 586 XMM-Newton observations. With this filtering, ∼1/2 of the observations are rendered unusable, and we are able to extract measurements from 303 observations. The oxygen intensities are typically ∼0.5-10 photons cm -2 s -1 sr -1 (line units, L.U.) for O VII and ∼0-5 L.U. for O VIII. The proton flux filtering does not systematically reduce the oxygen intensities measured from a given observation. However, the filtering does preferentially remove the observations with higher oxygen intensities. Our data set includes 69 directions with multiple observations, whose oxygen intensity variations can be used to constrain SWCX models. One observation exhibits an O VII enhancement of ∼25 L.U. over two other observations of the same direction, although most SWCX enhancements are ∼ 6 K, in good agreement with previous studies.

La etnobotánica: su alcance y sus objetos

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Schultes Richard Evans

1941-11-01

Full Text Available Existe entre la Botánica y la Antropología una ciencia intermedia a la que, desde hace medio siglo, se ha dado el nombre de Etnobotánica. Como ocurre con otras ciencias interfacultativas o interdisciplinales la Etnobotánica no se puede definir fácilmente y por esto ha habido muchas diferencias de opinión en cuanto a su alcance y sus objetos. En su más amplio sentido, la Etnobotánica es el estudio de las relaciones que existen entre el hombre y su ambiente vegetal, es decir las plantas que lo rodean. En un sentido más restringido, se ha considerado solamente como el estudio del uso de las plantas cultivadas y silvestres por los pueblos primitivos, usualmente los aborígenes.

Migrantes culiacanenses en California: Diversidad en sus redes migratorias

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Ernesto SÁNCHEZ SÁNCHEZ

2012-01-01

Full Text Available Es un hecho la dinámica extraordinaria que tienen los lugares de reciente migración, ya sea como lugares de origen o destino. El estado de Sinaloa se suma a esta dinámica en la cual aparecen ahora sus tres principales zonas urbanas --Culiacán, Mazatlán y Ahome-- dentro de su mapa migratorio. Sin embargo la migración, como proceso social, implica una serie de interrelaciones formadas tiempo atrás. Éstas repercuten en la conformación de las nuevas redes migratorias. No obstante, durante décadas, las principales zonas de expulsión en Sinaloa han sido rurales y siguen teniendo un papel esencial en las actuales relaciones sociales de los migrantes provenientes de Culiacán.

Persamaan Unsur Pokok Pada Suatu Merek Terkenal (Analisis Putusan MA Nomor 162 K/Pdt.Sus-HKI/2014

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Dandi Pahusa

2016-04-01

Full Text Available Abstract: Equation Basic Element In A Famous Brand (Analysis of the Decision of the Supreme Court Number 162 K / Pdt.Sus-IPR / 2014. Criteria for determining the equation of the constituents in a well-known brand that is the similarity of images, sounds, names, words, letters, numbers, color composition or a combination of these elements, either for goods or services that are similar or dissimilar based on general knowledge of the public, the brand earned a reputation as a massive campaign, and with evidence of the trademark registration in several countries. The impact of the decision of the Supreme Court Number 162 K / Pdt.Sus-IPR / 2014 for brand owners who have registered and well-known to always protect its brand, namely by taking into account the bad faith of the owner of the other brands. If there are other brands that have been registered in the Directorate General of Intellectual Property and published in General News Brands, the owner of the mark that has been registered in advance immediately appealed and the cancellation of the trademark. Abstrak: Persamaan Unsur Pokok Pada Suatu Merek Terkenal (Analisis atas Putusan MA Nomor 162 K/Pdt.Sus-HKI/2014. Kriteria penentuan persamaan unsur pokok pada suatu merek terkenal yaitu adanya kemiripan gambar, bunyi, nama, kata, huruf-huruf, angka-angka, susunan warna atau kombinasi dari unsur-unsur tersebut, baik terhadap barang atau jasa yang sejenis maupun tidak sejenis yang didasarkan pada pengetahuan umum masyarakat, reputasi merek yang diperoleh karena promosi besar-besaran, dan disertai bukti pendaftaran merek tersebut di beberapa negara. Dampak dari putusan Mahkamah Agung Nomor 162 K/Pdt.Sus-HKI/2014 bagi pemilik merek yang telah terdaftar dan terkenal agar selalu melindungi mereknya yaitu dengan memperhatikan adanya itikad tidak baik dari pemilik merek lain. Apabila terdapat merek lain yang telah terdaftar di Dirjen HKI dan diumumkan dalam Berita Umum Merek, maka pemilik merek yang telah

Insulinas Análogas: responsabilidade do SUS e a judicialização

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Jorge Lima

2015-12-01

Full Text Available Trata-se de um estudo descritivo, epidemiológico e analítico com abordagem qualiquantitativa. O artigo buscou identificar a relação entre cobertura da Estratégia de Saúde da Família e o aumento de ações judiciais de insulinas análogas nas regiões Sul e Nordeste do Brasil. Nos anos 2010, 2011 e 2012, o consumo de insulinas análogas foi crescente tanto na região sul quanto nordeste. A região sul, apesar de ter um SUS organizado, IDH desenvolvido e educação estruturada, apresentou falhas no programa de diabetes. Em contrapartida, a região nordeste possui IDH baixo na maioria dos municípios e educação deficiente, porém, observou-se a necessidade de reorganização dos programas voltados ao atendimento de usuários portadores de doenças crônicas, em especial, a diabetes, nessa região. Entende-se, que o fortalecimento da atenção básica como porta de entrada para o SUS, nas regiões estudadas pode minimizar o problema da judicialização da saúde.

Americo Vespucio - el Nuevo Mundo - Cartas relativas a sus viajes y descubrimientos

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Thomaz Oscar Marcondes de Souza

1952-03-01

Full Text Available "AMERICO VESPUCIO - EL NUEVO MUNDO - CARTAS RELATIVAS A SUS VIAJES Y DESCRUBIEMENTOS - TEXTOS EM ITALIANO, ESPANOL, INGLEZ. ESTUDIO PRELIMINAR DE ROBERTO LEVILLIER" (Primeiro Parágrafo do Artigo A "Editorial Nova" de Buenos Aires, acaba de publicar na sua "Biblioteca Americanista", todas as cartas atribuidas a Americo Vespucci, precedidas de um prefácio do ilustre historiador argentino professor dr. Roberto Levillier, personalidade esta bastante conhecida no nosso meio intelectual através do seu erudito trabalho América la bien llamada.

Violencia Filio Parental: Comparando lo que informan los adolescentes y sus progenitores

OpenAIRE

Calvete, Esther; Orue, Izaskun; González-Cabrera, Joaquín

2017-01-01

El objetivo principal del presente estudio fue examinar la consistencia de los informes de progenitores e hijos a la hora de informar sobre la violencia filio-parental en una muestra comunitaria. Como objetivo secundario, se exploraron las propiedades psicométricas de la versión para progenitores del Cuestionario de Violencia Filio-Parental (Calvete, Gámez-Guadix et al., 2013). Participaron en el estudio un total de 880 adolescentes (51.70% chicas, entre 13 y 19 años) y sus progenitores (76....

El ser humano y sus posibilidades de construcción desde el cuidado

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Alacoque Lorenzini Erdmann

2003-01-01

Full Text Available El artículo presenta algunas concepciones del ser humano en relación con el cuidado de enfermería. A partir de la organización de la vida se establecen relaciones, interacciones del ser humano, sus límites y posibilidades para el cuidado con la vida, con lo cotidiano y con la naturaleza. Resalta la importancia y el compromiso en la construcción colectiva del ser ciudadano.

El rol de las percepciones y los conocimientos de las madres en el estado nutricional de sus niños

OpenAIRE

Alcázar, Lorena; Marini, Alessandra; Walker, Ian

2011-01-01

El objetivo del presente estudio es analizar los factores determinantes de la desnutrición infantil (talla para la edad de los niños menores de 2 años), con énfasis en el análisis del rol del conocimiento de las madres sobre nutrición infantil en relación con el crecimiento y desarrollo de sus hijos. Se busca, además, explorar los mecanismos por cuya vía las madres obtienen estos conocimientos y forman sus percepciones, y analizar los canales mediante los cuales estos afectan el desarrollo de...

Crecimiento Post-traumático en supervivientes de cáncer y sus otros significativos. ¿Crecimiento vicario o secundario?

OpenAIRE

Ochoa Arnedo, Cristian; Castejón, V.; Sumalla, E.C.; Blanco Guillermo, Ignacio

2013-01-01

Las enfermedades graves como el cáncer, aunque generan elevado malestar emocional y estrés en los supervivientes y en sus otros significativos, también pueden suponer un estímulo en la generación de crecimiento postraumático en ambos. Los mecanismos de cómo se produce este crecimiento postraumático (vicario vs. secundario) en los otros significativos no se han estudiado. En esta revisión se analizan la evidencia y relación del crecimiento post-traumático en supervivientes de cáncer y en sus o...

Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A.

Science.gov (United States)

Nguyen, G N; George, L A; Siner, J I; Davidson, R J; Zander, C B; Zheng, X L; Arruda, V R; Camire, R M; Sabatino, D E

2017-01-01

Essentials Factor (F) VIII is an inefficiently expressed protein. Furin deletion FVIII variants were purified and characterized using in vitro and in vivo assays. These minimally modified novel FVIII variants have enhanced function. These variants provide a strategy for increasing FVIII expression in hemophilia A gene therapy. Background The major challenge for developing gene-based therapies for hemophilia A is that human factor VIII (hFVIII) has intrinsic properties that result in inefficient biosynthesis. During intracellular processing, hFVIII is predominantly cleaved at a paired basic amino acid cleaving enzyme (PACE) or furin cleavage site to yield a heterodimer that is the major form of secreted protein. Previous studies with B-domain-deleted (BDD) canine FVIII and hFVIII-R1645H, both differing from hFVIII by a single amino acid at this site, suggested that these proteins are secreted mainly in a single polypeptide chain (SC) form and exhibit enhanced function. Objective We hypothesized that deletion(s) of the furin site modulates FVIII biology and may enhance its function. Methods A series of recombinant hFVIII-furin deletion variants were introduced into hFVIII-BDD [Δ1645, 1645-46(Δ2), 1645-47(Δ3), 1645-48(Δ4), or Δ1648] and characterized. Results In vitro, recombinant purified Δ3 and Δ4 were primarily SC and, interestingly, had 2-fold higher procoagulant activity compared with FVIII-BDD. In vivo, the variants also have improved hemostatic function. After adeno-associated viral (AAV) vector delivery, the expression of these variants is 2-4-fold higher than hFVIII-BDD. Protein challenges of each variant in mice tolerant to hFVIII-BDD showed no anti-FVIII immune response. Conclusions These data suggest that the furin deletion hFVIII variants are superior to hFVIII-BDD without increased immunogenicity. In the setting of gene-based therapeutics, these novel variants provide a unique strategy to increase FVIII expression, thus lowering the vector dose, a

Morfología de Passiflora: una guía para la descripción de sus especies

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Miguel Macgayver Bonilla Morales

2015-03-01

Full Text Available Las pasifloras son un grupo de plantas que tienen uso desde periodos precolombinos por el sabor de sus frutos, sin embargo, en los últimos siglosse han encontrado compuestos de importancia farmacéutica para la salud humana. Desde esta perspectiva, conocer las especies mediante sus caracteres morfológicos permitirá explorar la variabilidadexistente a nivel intra e inter especifico, y también definir a futuro su importancia económicapor su uso potencial. Por tal motivo, el objetivo de esta investigación fue definir e ilustrar los caracteres morfológicos más utilizados en Passiflora L. para estudios de diversidad, caracterización y taxonomía en Colombia. De esta manera, se establecieron los ítems de hábito, raíz, tallo, estípula,hoja, flor, inflorescencia, fruto y semilla con sus respectivas descripciones que relacionan la taxonomía actual de Passiflora. Adicional, se añadióun componente de polinización que determinó las principales relaciones florísticas y polinizadores como insectos, aves y mamíferos. Se concluyeque el entendimiento de las estructuras morfológicas en Passiflora servirá de guía para trabajos de caracterización de germoplasma y revisionestaxonómicas como eje para describir nuevas especies. 

[SUS management and monitoring and evaluation practices: possibilities and challenges for building a strategic agenda].

Science.gov (United States)

Carvalho, André Luis Bonifácio de; Souza, Maria de Fátima; Shimizu, Helena Eri; Senra, Isabel Maria Vilas Boas; Oliveira, Kátia Cristina de

2012-04-01

This paper deals with the challenges involved in institutionalizing Monitoring and Evaluation practices within the scope of management of the Brazilian Unified Health System (SUS), based on the creation of a strategic agenda. This is structured around actions by the Federal Administration, from the perspective of defining the scope of the federative relationship. A summarized literature review is thus presented, placing into context the current SUS management process, which is based on the Pact for Health as well as theoretical and operational aspects inherent to monitoring and evaluation practices. The approach related to the strategic agenda highlights the creation of mechanisms that underpin the political and institutional decision, namely the creation of financial incentives and the development of technical mechanisms. These include organizational strategies for qualifying management teams and conducting studies and research and the dissemination of strategic information. These processes are based on the concept of providing for the management specificities in the different spheres of management based on a broad cooperation process involving teaching and research institutions and international organizations as well as the managers themselves.

Fatores de satisfação e insatisfação entre os pacientes assistidos pelo SUS

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Sérgio Ribeiro dos Santos

1999-03-01

Full Text Available Este estudo foi desenvolvido com o propósito de identificar os fatores que causam satisfação ou insatisfação nos pacientes internos em hospitais conveniados com o Sistema Único de Saúde (SUS, com base na assistência prestada durante o período de internação. A amostra foi constituída de cento e setenta pacientes. Para a coleta de dados, utilizou-se um questionário com quarenta e sete questões fechadas. Os resultados obtidos revelaram diversos aspectos que comprometem a qualidade do serviço prestado, tais como: serviço médico, nutrição, enfermagem e o ambiente. Assim, conclui-se que há insatisfação nos pacientes em relação aos serviços oferecidos pelo SUS.

Hepatozoon apri n. sp. (Adeleorina: Hepatozoidae from the Japanese wild boar Sus scrofa leucomystax (Mammalia: Cetartiodactyla

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Mizuki Yamamoto

2017-12-01

Full Text Available Hepatozoon apri n. sp. is described from Japanese wild boars Sus scrofa leucomystax in Japan. The gamonts in the peripheral blood leukocytes were 11.6 ± 1.4 × 6.7 ± 1.3 μm in size. The meronts in the muscle tissues were 35.0–47.5 μm in length and 26.5–30 μm in width. A high rate (53.0% of infection was found by nested PCR using muscle specimens from 181 wild boars captured in Tokushima, Japan. A phylogenetic analysis based on 18S rRNA gene sequences revealed that H. apri n. sp. detected in wild boars is closely related to Hepatozoon spp. isolated from carnivores. This is the first description of a species belonging to the genus Hepatozoon detected in ungulates. Keywords: Sus scrofa leucomystax, Hepatozoonosis, Wild boar, Hepatozoon apri n. sp., 18S rRNA gene, Japan

Virulencia de cepas de Listeria monocytogenes procedentes de cabras y sus derivados

OpenAIRE

Guicela Ramírez Bernal; Alma Virginia Lara Sagahón; Carlos Gerardo García Tovar; Efrén Díaz Aparicio; Víctor Rubén Tenorio Gutiérrez

2014-01-01

Se evaluó la virulencia de cepas de Listeria monocytogenes todas de serotipo 4b procedentes de cabras y sus derivados. Se observaron niveles de virulencia variables cuando se comparó la virulencia relativa (porcentaje de letalidad) en ratones BALB/c inoculados vía intravenosa o intragástrica y su capacidad para infectar macrófagos J774A.1, y células epiteliales Caco-2. Dos cepas obtenidas de alimento de cabras produjeron 100 % de letalidad por ambas vías de inoculación y no mostraron diferenc...

Skeletal, dental and profilometric effects of Sabbagh Universal Spring 2 (SUS2 in a patient at the end of growth: a case report

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Marchionni, P.

2016-04-01

Full Text Available Introduction: Malocclusions, which present a severe skeletal component, are difficult to solve through orthodontic treatment inpatients at the end of growth and often require a combined orthodontic-surgical treatment. The mandibular propulsion appliances "no compliance" now offer new possibilities for functional orthopedic treatment in borderline cases. Case presentation: A patient at the end of growth with a severe malocclusion (Class II Division 1, open bite with arches' transversaldiscrepancy, refused the hypothesis of an orthodontic-surgical treatment, which represents the gold standard in such occlusal andskeletal problems, especially in subjects at the end of growth; consequently, a complex orthopedic-orthodontic treatment was chosen as the second choice. The patient has been successfully treated also through the use of SUS2 (Sabbagh Universal Spring 2; Dentaurum, Ispringen, Germany, a "no compliance" fixed functional appliance, which carried out a significant sagittal correction. Conclusion: The case report especially highlights the important sagittal correction obtained through the use of SUS2. The SUS2 had a functional outcome, which resulted in the maxillary growth stop and an effective sagittal mandibular growth increase. The SUS2effects, enhanced by elastics biomechanics, led to the bite closure and at the achievement of Class I occlusion.

Direct Observation of the M1 Transition between the Ground Term Fine Structure Levels of W VIII

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Momoe Mita

2017-03-01

Full Text Available We present a direct observation of the M1 transition between the fine structure splitting in the 4 f 13 5 s 2 5 p 6 2 F ground term of W VIII. The spectroscopic data of few-times ionized tungsten ions are important for the future ITER diagnostics, but there is a serious lack of data. The present study is part of an ongoing effort to solve this problem. Emission from the tungsten ions produced and trapped in a compact electron beam ion trap is observed with a Czerny–Turner visible spectrometer. Spectra in the EUV range are also observed at the same time to help identify the previously-unreported visible lines. The observed wavelength 574.47 ± 0.03 nm (air, which corresponds to the fine structure splitting of 17,402.5 ± 0.9 cm − 1 , shows reasonable agreement with the previously reported value 17,410 ± 5 cm − 1 obtained indirectly through the analysis of EUV spectra [Ryabtsev et al., Atoms 3 (2015 273].

Bianchi - I, II, VIII, IX and Kantowski-Sachs-like cosmological models with perfect fluid and electromagnetic fields with conductivity current

International Nuclear Information System (INIS)

Portugal, R.

1984-01-01

Three processes of solutions of the Einstein-Maxwell equations for Bianchi - I, II, VIII, IX and Kantowski-Sachs-like cosmological models with perfect fluid in magnetohydrolodynamical regimem are presented. Diagonal Bianchi-like models are considered with two anisotropy direction in the maximum. Solutions are found for Bianchi-II and IX-like models with energy conditions to be analyzed. Solutions are found for Bianchi-IX and Kantowski-Sachs-Like models with positive electric conductivity and satisfering to the predominant energy conditions. Solutions are formed for isotropic Kantowski-Sachs-Like models satisfering to the equation of state p=λρ, 0 0, admiting, in addition to the perfect fluid, electric field only. It is shown that a class of Bertotti-Robinson-like solutions is unstable by perturbations and it is carried in Kantowski-Sachs-like models with non-null electric conductivity. (L.C.) [pt

Mis colaboradores no se comprometen con la empresa y sus objetivos

OpenAIRE

Vega Jimenez, Mabel Angelica

2017-01-01

La tesis plantea cómo se hace que el ser personal emerja del ser humano en una empresa u organización, y se comprometa y una al propósito o misión de la organización y sus dueños; cómo se hace que una empresa desarrolle y fortalezca su entraña empresarial. De qué manera pueden los gerentes contribuir con esta gran misión de lograr unidad y alcanzar metas con una "diversidad" humana interactuando unos con otros, cuando la dirección solo mira y exige metas. Trabajo de investigación

A disputa entre o Papa Bonifácio VIII e o Rei Filipe IV no final do século XIII

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Strefling, Sérgio Ricardo

2007-01-01

Full Text Available A questão das relações entre Igreja e Estado provocou debates prolongados e acesos, principalmente durante a idade média, no momento em que a igreja, dotada de um domínio próprio temporal, encontrava-se em convívio com o Sacro Império Romano que abraçava os mesmos súditos e apoiava-se sobre bases jurídicas derivadas do Cristianismo. Sob tal situação ainda era possível manter uma diferenciação entre estado e Igreja? No presente estudo, apresentaremos a polêmica causada pela teoria do Papa Bonifácio VIII no conflito com o Rei Filipe, o Belo. Daí surgem três documentos importantes, entre eles, a Bula Unam Sanctam

Ser padre fuera de la familia: subjetividad y vínculos de varones padres que ya no viven con sus hijos

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Genoveva Echeverría Gálvez

2012-01-01

Full Text Available La reflexión teórica toma elementos de los estudios de las masculinidades, así como desde una mirada desde la cultura y sus discursos acerca de las subjetividades y los vínculos actuales. En este contexto la familia -como constructo y como materialidad- cobra gran relevancia. En este caso las preguntas se orientaron a conocer las construcciones de subjetividades de varones que están actualmente separados, pero mantienen relaciones con sus hijos. Se realizaron entrevistas en profundidad a 10 hombres chilenos adultos, y luego se aplicó la técnica de análisis de discursos. Los resultados y conclusiones más relevantes apuntan que el ser varón es un lugar de tensión, situación que se vuelve más compleja al estar ellos fuera del marco familiar. El imaginario de familia nuclear sigue operando en ellos y les dificulta la valoración de sus nuevos vínculos y experiencias.

Las políticas sociales de dependencia en España: contribuciones y consecuencias para los ancianos y sus cuidadores informales

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Bibiana Escuredo

2007-01-01

Full Text Available Se presenta la evolución de la protección social de la dependencia en España desde la década de los noventa hasta el momento actual y se plantean las consecuencias de la falta de acuerdo político respecto a las medidas a implementar. Se analizan los elementos en los que se basan las políticas de dependencia, resaltando sus aspectos positivos y negativos, así como las consecuencias para los ancianos y sus cuidadores informales. También se pone de manifiesto cómo, ante la posibilidad de quiebra del papel de la familia en el cuidado de los dependientes, se están implementando políticas que tienen como objetivo reforzar el rol cuidador de la familia y que se enmarcan dentro de la denominada "Conciliación de la Vida Familiar y Laboral". Estas políticas, más allá de sus contribuciones positivas, implican también importantes costes personales y de oportunidad para los cuidadores informales.

Clima motivacional en Educación Física: concordancia entre las percepciones de los alumnos y las de sus profesores

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Melchor Guti\\u00E9rrez

2011-01-01

Full Text Available En este estudio se han comparado las percepciones de alumnos y profesores sobre el clima motivacional de las clases de educación física. Los participantes, 2189 alumnos de 13 a 17 años y sus 94 profesores, completaron una versión española de L'Echelle de Perception du Climat Motivational (EPCM. Los análisis factoriales confirmatorios (AFC de primer y segundo orden han confirmado la estructura factorial de la versión original de la escala. Un análisis de concordancia entre las percepciones de los alumnos y las de sus profesores sobre el clima motivacional de la clase indicó que únicamente coinciden en el factor Búsqueda de Comparación por los Alumnos. Por otro lado, los análisis diferenciales han mostrado que los alumnos perciben un Clima de Ejecución más elevado, mientras que los profesores perciben mayor Clima de Maestría en las clases de educación física. Se discuten los resultados de cara a sus implicaciones para los educadores físicos.

The spectrum of seven times ionized tungsten (W VIII) relevant to tokamak divertor plasmas

International Nuclear Information System (INIS)

Ryabtsev, A N; Kononov, E Ya; Kildiyarova, R R; Tchang-Brillet, W-Ü L; Wyart, J-F

2013-01-01

Tungsten spectra excited in the vacuum sparks of different setups and electric circuits were recorded on two high-resolution vacuum spectrographs. For the region 190–500 Å, a 10 m normal incidence spectrograph with a 3600 lines/mm grating was used in the Meudon Observatory. In the region below 350 Å, a set of spectra was produced using a 3 m grazing incidence spectrograph with a 3600 lines/mm grating in the Institute of Spectroscopy in Troitsk. A total of 187 lines in the region 160–271 Å were identified as transitions to the low-lying odd configurations 4f 13 5s 2 5p 6 and 4f 14 5s 2 5p 5 from the interacting excited even 4f 12 5s 2 5p 6 5d + 4f 13 5s 2 5p 5 (5d + 6s) + 4f 14 5s 2 5p 4 (5d + 6s) + 4f 14 5s5p 6 configurations. It was found that 4f 13 5s 2 5p 6 2 F 7/2 is the ground level of W VIII. The fine structure splitting and relative positions of the odd terms were established, and 98 levels of the excited even configurations were found. (paper)

La red de monitoreo glacio-hidrologico de ORSTOM y de sus contrapartes en Bolivia, Peru y Ecuador : une herramienta para el estudio del recalentamiento global y de sus consecuencias en los tropicos

OpenAIRE

Pouyaud, Bernard; Francou, Bernard; Ribstein, Pierre

1995-01-01

Desde hace algunos años, junto con sus contrapartes sudamericanas de Bolivia, Peru y Ecuador, ORSTOM mantiene una red de mediciones en algunos glaciares representativos de estos 3 paises. Los glaciares tropicales son, en efecto, objetos hidrologicos que integran particularmente bien los efectos de un cambio climatico. Es asi que los primeros resultados evidenciaron la influencia de los acontecimientos ENSO sobre la hidrologia glaciar, con efectos contrastados en la Cordillera Real de Bolivia ...

Mejoramiento genético acelerado de angiospermas perennes vía inducción floral por sobre-expresión del gen FT

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Rafael Urrea López

2018-05-01

Full Text Available Los bosques y selvas enfrentan el reto de satisfacer la demanda por recursos de una población en crecimiento, así como la amenaza del rápido cambio climático que exacerba la magnitud y frecuencia de estreses bióticos y abióticos. Para ello, es urgente acelerar el mejoramiento genético de especies forestales. Sin embargo, sus largas etapas juveniles y asincronía floral retrasan peligrosamente este proceso. El presente ensayo explora los adelantos biotecnológicos en inducción floral y su potencial aplicación en especies forestales. Entre los genes identificados y caracterizados que participan en la ruta de señalización de la floración, especial atención se destina al gen FLOWERING LOCUS T, considerado un integrador de rutas de señalización altamente conservado entre las angiospermas, que, al sobre-expresarse por ingeniería genética, es capaz de inducir la floración de forma eficiente. Esta novedosa estrategia biotecnológica se ha utilizado, recientemente, para segregar genes de resistencia a enfermedades, en un menor tiempo, en germoplasma comercial de manzana y ciruela. Permite soslayar barreras naturales que por mucho tiempo han restringido a las especies forestales al mejoramiento por selección, principalmente. Entre sus ventajas está la de poder restringirla al proceso y no al producto, para acelerar las cruzas sexuales sin modificar genéticamente la progenie; se aleja así de la controversia alrededor de la liberación y consumo de organismos genéticamente modificados, y de los costos y trámites obligatorios para los OGM para monitoreo de posibles riesgos. Se proyecta como una tecnología que puede acelerar, significativamente, el mejoramiento de especies forestales.

Opinião do graduando de enfermagem sobre a formação do enfermeiro para o SUS: uma análise da FAEN/UERN Opinión del estudiante de enfermería sobre la formación del enfermero para el sus: un análisis de la FAEN/UERN Opinion of the nursing graduate student on the formation of nurses for sus: an analysis of FAEN/UERN

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Roberta Kaliny de Souza Costa

2010-03-01

Full Text Available O estudo objetivou identificar a opinião dos graduandos sobre seu processo de formação para o Sistema Único de Saúde - SUS. O objeto é a opinião dos graduandos de enfermagem sobre sua formação para o SUS. Pesquisa quantitativa, realizada com 30 discentes da Faculdade de Enfermagem - FAEN, unidade integrante da Universidade do Estado do Rio Grande do Norte - UERN. Observaram-se os aspectos éticos da Resolução 196/96 do Conselho Nacional de Saúde, incluindo a assinatura do Termo de Consentimento Livre e Esclarecido pelos discentes. Os dados foram coletados por meio de questionários, tabulados no Microsoft Excel e apresentados em tabelas. Os resultados, apesar de apontarem alguma rejeição em certos aspectos da proposta curricular, revelaram uma boa aceitação dos discentes quanto à eficiência e realização dos objetivos do Projeto Político-Pedagógico, do perfil do egresso pretendido por esse projeto de ensino, bem como de seus aspectos organizacionais, implantados em 1996, ainda vigentes.El presente estudio tuvo como objetivo identificar la opinión que tienen los estudiantes sobre el proceso de formación para el Sistema Único de Salud SUS. El objeto es registrar la opinión de los estudiantes de enfermería sobre su formación para el SUS. Investigación cuantitativa, realizada con 30 estudiantes de la Facultad de Enfermería FAEN, unidad componente de la Universidad del Estado de Rio Grande del Norte UERN. Se analizaron los aspectos éticos de la Resolución 196/96 del Concejo Nacional de Salud, incluyendo la firma del Término de Consentimiento Libre, con el consentimiento de los estudiantes. Los datos fueron colectados por medio de cuestionarios, tabulados en Microsoft Excel y presentados en tablas de datos. Los resultados, a pesar de reflejar algún rechazo de ciertos aspectos de la propuesta curricular, denotaron una buena aceptación de los estudiantes en relación a la eficiencia y cumplimiento de los objetivos del

Teaching at primary healthcare services within the Brazilian national health system (SUS in Brazilian healthcare professionals' training

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Ramona Fernanda Ceriotti Toassi

2013-06-01

Full Text Available The aim of this study was to analyze the role of teaching at primary healthcare services within the Brazilian National Health System (SUS in dentists' training, at a public university in the south of Brazil. A qualitative methodological approach (case study was used. Interviews were conducted with 12 dentistry students, six dentists who were preceptors working in public primary healthcare services and three teachers connected with this curricular training. Our findings showed that the curricular training in SUS primary healthcare services had an impact on the dentists' education through establishment of bonds, autonomy in problem-solving and multiprofessional teamwork. It was seen that they learned about how healthcare services function, about healthcare and about development of cultural competence. There is a need to maintain constant questioning regarding these practices, and to ensure the presence of infrastructure and qualified professionals for teaching at these services.

El ADN de la marca. La concepción de sus valores intangibles en un contexto dialogado

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Jaime Alberto Orozco Toro

2012-01-01

Full Text Available Aún hoy, en plena sociedad del conocimiento, se tienen límites conceptuales en relación con aspectos tan fundamentales como la identidad, la imagen y la reputación de marca. Incluso donde mayores dificultades se presentan es en las posibilidades de evaluación y medición de cada uno de estos conceptos ligados con la reputación empresarial. Así, la marca, como el elemento fundamental de las empresas del presente siglo, se ve obligada a indagar nuevas formas de interpretar sus acciones estratégicas, con el único objetivo de continuar conformando la estructura de la marca, el ADN que la diferencia y que le permite contrastar sus resultados a partir de evaluaciones y mediciones fiables, en un contexto donde la transparencia, ante el alud de comunicación, se plantea casi como una exigencia.

La productividad española: características y sus causas (1995-2013)

OpenAIRE

Jalón Aymerich, Francisco de Borja

2015-01-01

El objetivo del presente ensayo es comprender algunos de los determinantes que afectan el comportamiento de la productividad laboral española además de describir sus características. Se discuten algunas de las explicaciones ofrecidas por la literatura económica y se analizan algunas posibilidades, encontrando que el tamaño empresarial y la distribución de valor añadido entre grupos de tamaño es uno de los determinantes principales de la productividad.

Efectos de la atención dividida sobre la memoria episódica y sus respuestas neurofisiológicas en adultos jóvenes y mayores /

OpenAIRE

Trejo Morales, Martha Patricia

2012-01-01

 tesis que para obtener el grado de Doctor en Psicología, presenta Martha Patricia Trejo Morales ; asesor Selene Cansino Ortíz, Yolanda del Río Portilla, Erzsébet Maroshi Holczberger, María Corsi Cabrera, Guillermina Yáñez Téllez, Dolores Rodríguez Ortíz, Mario Rodríguez CamachoVIII, 129 páginas : diagramasDoctorado en Psicología UNAM, Facultad de Psicología, 2012

HERRAMIENTAS PARA LA GESTION DE PABELLONES QUIRURGICOS Y DE SUS RECURSOS ASOCIADOS

OpenAIRE

RAMIS LANYON, FRANCISCO JAVIER

2013-01-01

Los centros de salud públicos programan y coordinan el uso de sus pabellones de forma manual y empírica, esto se traduce en la perdida de eficiencia en la asignación de recursos físicos y humanos. Situación agravada por el uso de sistemas de costeo inadecuados para la asignación de gastos a los productos y servicios entregados, o bien derivados por la utilización de los servicios de cirugía en recintos asistenciales públicos. El proyecto D07I1012, denominado “Herramientas para al ...

El Protocolo de Montreal relativo a las sustancias que agotan la capa de ozono (1999) y la enmienda de Beijing. Un análisis de sus contenidos, alcances y sus percusiones presentes.

OpenAIRE

Zúñiga, Francisco Javier

2015-01-01

El presente ensayo consta de cuatro partes, una desarrolla de manera actualizadalos alcances del Protocolo de Montreal ysus enmiendas, la segunda examina los alcances de la Enmienda de Beijing, seguido de un análisis del impacto que hatenido el Protocolo de Montreal para el país. Finalmente se repasa la ejecución del Protocolo y sus enmiendas en nuestropaís y se agregan consideraciones que su implementación ha supuesto en el desarrollo ...

La cuenca del Río Pardo (Brasil y sus estrategias de desarrollo rural sostenible

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Wanderleia Elizabeth Brinckmann

2002-01-01

Full Text Available La finalidad del presente artículo consiste en estudiar el cuadro socioeconómico y ambiental de la agricultura familiar en la Cuenca Hidrográfica del Río Pardo, Brasil. Se busca analizar la producción agroecológica, sus dificultades y potencialidades. El análisis se refiere a las estrategias de desarrollo rural sostenible en curso en la Cuenca Hidrográfica del Río Pardo.

Uso de derivados de quinazollnas y sus composiciones farmacéuticas en enfermedades neurodegenerativas

OpenAIRE

Martínez, Ana; Redondo, Miriam; Sanz-SanCristóbal, Marina; Gil, Carmen; Morales-García, José A.; Pérez Castillo, Ana; Pérez Martín, María Concepción

2009-01-01

Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas. La invención se refiere a derivados heterocíclicos de quinazolinas y a su potencial para el tratamiento de enfermedades neurodegenerativas y/o neurológicas, entre otras la enfermedad de Parkinson, enfermedad de Alzheimer o esclerosis. Además, la invención se refiere a composiciones farmacéuticas que comprenden dichos compuestos derivados de quinazolinas.

SusDesign - An approach for a sustainable process system design and its application to a thermal power plant

Energy Technology Data Exchange (ETDEWEB)

Abul Hossain, K; Khan, F; Hawboldt, K [Mem University of Newfoundland, St John, NF (Canada). Faculty of Engineering & Applied Science

2010-10-15

This paper presents a structured process design approach, SusDesign, for the sustainable development of process systems. At each level of process design, design alternatives are generated using a number of thermodynamic tools and applying pollution prevention strategies followed by analysis, evaluation and screening processes for the selection of potential design options. The evaluation and optimization are carried out based on an integrated environmental and cost potential (IECP) index, which has been estimated with the IECP tool. The present paper also describes a flowsheet optimization technique developed using different thermodynamic tools such as exergy/energy analysis, heat and mass integration, and cogeneration/trigeneration in a systematic manner. The proposed SusDesign approach has been successfully implemented in designing a 30 MW thermal power plant. In the case study, the IECP tool has been set up in Aspen HYSYS process simulator to carry out the analysis, evaluation and screening of design alternatives. The application of this approach has developed an efficient, cost effective and environmentally friendly thermal system design with an overall thermal efficiency of 70% and CO{sub 2} and NO emissions of 0.28 kg/kW h and 0.2 g/kW h respectively. The cost of power generation is estimated as 4 cents kWh. These achievements are significant compared to the conventional thermal power plant, which demonstrates the potential of the SusDesign approach for the sustainable development of process systems.

SusDesign - An approach for a sustainable process system design and its application to a thermal power plant

Energy Technology Data Exchange (ETDEWEB)

Hossain, Khandoker Abul [Faculty of Engineering and Applied Science Memorial University of Newfoundland, St. John' s, NL, A1B 3X5 (Canada); Khan, Faisal [Faculty of Engineering and Applied Science Memorial University of Newfoundland, St. John' s, NL, A1B 3X5 (Canada); Hawboldt, Kelly [Faculty of Engineering and Applied Science Memorial University of Newfoundland, St. John' s, NL, A1B 3X5 (Canada)

2010-10-15

This paper presents a structured process design approach, SusDesign, for the sustainable development of process systems. At each level of process design, design alternatives are generated using a number of thermodynamic tools and applying pollution prevention strategies followed by analysis, evaluation and screening processes for the selection of potential design options. The evaluation and optimization are carried out based on an integrated environmental and cost potential (IECP) index, which has been estimated with the IECP tool. The present paper also describes a flowsheet optimization technique developed using different thermodynamic tools such as exergy/energy analysis, heat and mass integration, and cogeneration/trigeneration in a systematic manner. The proposed SusDesign approach has been successfully implemented in designing a 30 MW thermal power plant. In the case study, the IECP tool has been set up in Aspen HYSYS process simulator to carry out the analysis, evaluation and screening of design alternatives. The application of this approach has developed an efficient, cost effective and environmentally friendly thermal system design with an overall thermal efficiency of 70% and CO{sub 2} and NO emissions of 0.28 kg/kW h and 0.2 g/kW h respectively. The cost of power generation is estimated as 4 cents /kW h. These achievements are significant compared to the conventional thermal power plant, which demonstrates the potential of the SusDesign approach for the sustainable development of process systems.

SusDesign - An approach for a sustainable process system design and its application to a thermal power plant

International Nuclear Information System (INIS)

Hossain, Khandoker Abul; Khan, Faisal; Hawboldt, Kelly

2010-01-01

This paper presents a structured process design approach, SusDesign, for the sustainable development of process systems. At each level of process design, design alternatives are generated using a number of thermodynamic tools and applying pollution prevention strategies followed by analysis, evaluation and screening processes for the selection of potential design options. The evaluation and optimization are carried out based on an integrated environmental and cost potential (IECP) index, which has been estimated with the IECP tool. The present paper also describes a flowsheet optimization technique developed using different thermodynamic tools such as exergy/energy analysis, heat and mass integration, and cogeneration/trigeneration in a systematic manner. The proposed SusDesign approach has been successfully implemented in designing a 30 MW thermal power plant. In the case study, the IECP tool has been set up in Aspen HYSYS process simulator to carry out the analysis, evaluation and screening of design alternatives. The application of this approach has developed an efficient, cost effective and environmentally friendly thermal system design with an overall thermal efficiency of 70% and CO 2 and NO emissions of 0.28 kg/kW h and 0.2 g/kW h respectively. The cost of power generation is estimated as 4 cents /kW h. These achievements are significant compared to the conventional thermal power plant, which demonstrates the potential of the SusDesign approach for the sustainable development of process systems.

Estado del Arte: El Banco Central de Estados Unidos a sus 100 años

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Jane D'Arista

2013-09-01

Full Text Available La creencia en la hipótesis de los mercados eficientes y la adopción de requerimientos de capital para los bancos como la mejor herramienta macroprudencial compatible con las fuerzas del mercado, reemplazó el compromiso previo de la Reserva Federal (Fed de emplear la conexión entre las operaciones de mercado abierto y los cambios en los requerimientos de reservas para limitar el crédito. Desde que se cortó esta palanca sobre la oferta crediticia, el banco central ha dependido de las operaciones de mercado abierto para lograr solamente un objetivo: influir sobre la demanda de crédito cambiando la tasa de referencia de corto plazo. La desequilibrada caja de herramientas contribuyó a un sesgo procíclico en los resultados de sus políticas que reflejó y exacerbó el sesgo procíclico del sistema financiero. El fracaso de evaluar y fortalecer sus herramientas monetarias ha socavado la habilidad de la Fed para restaurar el crecimiento económico y evitar otra crisis financiera. La traducción del inglés al español es de Wesley Marshall y Eugenia Correa.

PENINGKATAN HASIL BELAJAR PELAKU-PELAKU KEGIATAN PEREKONOMIAN DI INDONESIA DENGAN MODEL PEMBELAJARAN THINK PAIR AND SHAREPADA SISWA KELAS VIII SMP PGRI BERGAS

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Ani Sumaiyah

2002-06-01

Full Text Available Dalam proses belajar mengajar guru memegang peranan penting yaitu sebagai fasilitator dalam mengoptimalkan keaktifan siswa. Hasil� observasi awal menunjukkan bahwa kelas VIII� ada 17 siswa (65,3% belum tuntas pada nilai materi pelaku-pelaku kegiatan perekonomian di Indonesia. Hasil tersebut belum optimal karena perhatian siswa kurang, partisipasi anak kurang menyeluruh. Subyek penelitian ini adalah siswa kelas VIII. Prosedur penelitian ini merupakan siklus kegiatan yang terdiri dari dua siklus dimana setiap siklus meliputi perencanaan, pelaksanaan tindakan, pengamatan dan refleksi. Hasil baik pada siklus I maupun siklus II terlihat bahwa nilai rata-rata hasil belajar kognitif siswa meningkat yaitu dari skor awal yaitu dari rata-rata awal sebesar 66,9 menjadi 73,2pada siklus I dan 84,2 pada siklus II dan ketuntasan klasikal dari 34,6% menjadi 65,3% pada siklus I dan 92,3% pada siklus II. In teaching and learning education, teachers play an important role as a facilitator in optimizing the activity of students. Teachers are expected to use appropriate teaching methods to involve more students in the teaching-learning process. The results of preliminary observations suggest that class VIII (65,3% who have not completed the economic value of the material perpetrators of the economic activities in Indonesia.Results are not optimal because attention ofstudents are less, participation of children less comprehensive, students have a fairly good activity, but not channeled properly.The procedure of this research is a cyclical activity that consists of two cycles where each cycle includes planning, implementation of the action, observation and reflection.Good results in cycle I and cycle II shows that the average value of cognitive learning outcomes that students increased from the initial score from the initial average of 66.9 to 73.2 to 84.2 in cycle I and cycle II and classical completeness from 34,6% to 65.3% in cycle I and 92.3% in cycle II.

Las exenciones tributarias del impuesto a la renta y sus efectos fiscales 2008

OpenAIRE

Marchán Rumbea, Jorge Antonio

2010-01-01

La presente investigación en su primer capítulo realiza una fundamentación de los aspectos jurídico económicos y sociales de las exenciones tributarias. La sustentación parte del modelo de desarrollo a implementarse, de la Constitución Política del Ecuador, de sus políticas económicas y fiscales. Detalla las diferentes exoneraciones tributarias por tipos de actividades y contribuyentes, y su respectiva prevalencia de la norma tributaria sobre otros cuerpos legales. Se describe ...

La reforma constitucional y sus efectos en las relaciones Iglesia-Estado

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María del Carmen García Aguilar

2004-02-01

Full Text Available A poco más de una década de la reforma de los artículos constitucionales 3º, 5º, 24, 27, y 130, esta comunicación intenta identificar los impactos sociopolíticos gestados por esta nueva legalidad en las relaciones Estado-iglesias. La reforma constitucional de 1992 que dota de personalidad jurídica a las instituciones religiosas y las iguala con las asociaciones civiles en derechos y obligaciones, marca un punto de inflexión no sólo en los enfoques del estudio de las instituciones eclesiales sino también, en el hecho religioso mismo y sus prácticas en Chiapas.

Reflexiones sobre la guerra y sus implicaciones en la salud humana

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. Luis Angel Pérez Flerima

2017-11-01

Full Text Available El presente trabajo está dirigido a la reflexión de un fenómeno complejo y dramático para la vida de millones de seres humanos en el mundo como es la guerra, que con el avance científico- tecnológico ha hecho más terrible su impacto con la correspondiente secuela para la humanidad. Este artículo expresa sucintamente los orígenes de la guerra, el papel que los Estados Unidos desempeñan en los diferentes conflictos regionales como principal potencia imperialista. Por ello se valora el fenómeno de la guerra y sus implicaciones en la salud humana.

Extended analysis of Br VIII and predicted trends for the n=4, Δn=0 transistions of nickel-like ions (Kr IX-Mo XV)

International Nuclear Information System (INIS)

Wyart, J.F.; Ryabtsev, A.N.

1986-01-01

More than one hundred lines of Br VIII have been classified in the spectral region 416-824 A, from which all levels of 3d 9 4d (except 1 S 0 ) have been found. The energy levels of the configurations 3d 9 4s, 3d 9 4p and 3d 9 4d have been interpreted from Zn III to Mo XV by means of the Slater-Condon theory and of generalized least squares techniques and the root mean square deviations are 8, 51 and 40 cm -1 respectively. The strongest lines of the 4s-4p and 4p-4d transitions are predicted from Kr IX to Mo XV. (orig.)

Subcooled boiling heat transfer in a short vertical SUS304-tube at liquid Reynolds number range 5.19 x 104 to 7.43 x 105

International Nuclear Information System (INIS)

Hata, Koichi; Masuzaki, Suguru

2009-01-01

The subcooled boiling heat transfer and the steady-state critical heat fluxes (CHFs) in a short vertical SUS304-tube for the flow velocities (u = 17.28-40.20 m/s), the inlet liquid temperatures (T in = 293.30-362.49 K), the inlet pressures (P in = 842.90-1467.93 kPa) and the exponentially increasing heat input (Q = Q 0 exp(t/τ), τ = 8.5 s) are systematically measured by the experimental water loop comprised of a multistage canned-type circulation pump with high pump head. The SUS304 test tubes of inner diameters (d = 3 and 6 mm), heated lengths (L = 33 and 59.5 mm), effective lengths (L eff = 23.3 and 49.1 mm), L/d (=11 and 9.92), L eff /d (=7.77 and 8.18), and wall thickness (δ = 0.5 mm) with average surface roughness (Ra = 3.18 μm) are used in this work. The inner surface temperature and the heat flux from non-boiling to CHF are clarified. The subcooled boiling heat transfer for SUS304 test tube is compared with our Platinum test tube data and the values calculated by other workers' correlations for the subcooled boiling heat transfer. The influence of flow velocity on the subcooled boiling heat transfer and the CHF is investigated into details and the widely and precisely predictable correlation of the subcooled boiling heat transfer for turbulent flow of water in a short vertical SUS304-tube is given based on the experimental data. The correlation can describe the subcooled boiling heat transfer obtained in this work within 15% difference. Nucleate boiling surface superheats for the SUS304 test tube become very high. Those at the high flow velocity are close to the lower limit of Heterogeneous Spontaneous Nucleation Temperature. The dominant mechanisms of the flow boiling CHF in a short vertical SUS304-tube are discussed.

Desempeño de las empresas propiedad de sus trabajadores: ¿Un modelo de gobierno corporativo laboral?

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Josefina Fernández-Guadaño

2016-03-01

Full Text Available En épocas de crisis, las empresas propiedad de sus trabajadores despiertan un renovado interés como fórmulas para el mantenimiento del empleo y sostenibilidad del tejido productivo del entorno donde se ubican. También hay un interés creciente en la literatura económica por medir el desempeño empresarial e inferir, a partir de las posibles diferencias, pautas que permitan incrementar la eficiencia, competitividad y productividad empresarial. Por ambos motivos este trabajo analiza el desempeño medido a través de diferentes indicadores económicos de las empresas propiedad de sus trabajadores y compara los resultados con los obtenidos por las empresas capitalistas convencionales. Estos resultados constatan diferencias significativas en diversas variables económico-financieras congruentes con las diferentes estructuras de propiedad del capital de ambas formas societarias, pero que no son determinantes para abogar por un modelo de gobierno corporativo laboral.

Las cooperativas y sus prácticas de resolución de conflictos desde el enfoque cualitativo

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Jesús González

2011-10-01

Full Text Available En las cooperativas existen condiciones sociales que dan cuenta del conflicto y sus procesos sociales constitutivos en este tipo de organizaciones comunitarias, que por lo general no se alcanzan a percibir ni a comprender tan categóricamente bajo el enfoque de la metodología cuantitativa; de allí que el objeto del presente trabajo sea presentar los lineamientos generales para el estudio de las cooperativas y sus prácticas de resolución de conflictos desde el enfoque cualitativo. La metodología es de tipo teórico-documental dentro del cual se recurrió a técnicas como la revisión documental y el análisis de fuentes primarias. Entre los planteamientos más sobresalientes de este trabajo se tiene que el enfoque cualitativo favorece el desarrollo de categorías analíticas que no resultan del interés del investigador sino de los señalamientos de los propios sujetos participantes

Frequencies of VNTR and RFLP polymorphisms associated with factor VIII gene in Singapore

Energy Technology Data Exchange (ETDEWEB)

Fong, I.; Lai, P.S.; Ouah, T.C. [National Univ. of Singapore (Malaysia)] [and others

1994-09-01

The allelic frequency of any polymorphism within a population determines its usefulness for genetic counselling. This is important in populations of non-Caucasian origin as RFLPs may significantly differ among ethnic groups. We report a study of five intragenic polymorphisms in factor VIII gene carried out in Singapore. The three PCR-based RFLP markers studied were Intron 18/Bcl I, Intron 19/Hind III and Intron 22/Xba I. In an analysis of 148 unrelated normal X chromosomes, the allele frequencies were found to be A1 = 0.18, A2 = 0.82 (Bcl I RFLP), A1 = 0.80, A2 = 0.20 (Hind III RFLP) and A1 = 0.58, and A2 = 0.42 (Xba I RFLP). The heterozygosity rates of 74 females analyzed separately were 31%, 32% and 84.2%, respectively. Linkage disequilibrium was also observed to some degree between Bcl I and Hind III polymorphism in our population. We have also analyzed a sequence polymorphism in Intron 7 using hybridization with radioactive-labelled {sup 32}P allele-specific oligonucleotide probes. This polymorphism was not very polymorphic in our population with only 2% of 117 individuals analyzed being informative. However, the use of a hypervariable dinucleotide repeat sequence (VNTR) in Intron 13 showed that 25 of our of 27 (93%) females were heterozygous. Allele frequencies ranged from 1 to 55 %. We conclude that a viable strategy for molecular analysis of Hemophilia A families in our population should include the use of Intron 18/Bcl I and Intron 22/Xba I RFLP markers and the Intron 13 VNTR marker.

Infobarris: una herramienta interactiva para monitorizar y divulgar información sobre la salud y sus determinantes en los barrios de Barcelona

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Pere Llimona

2017-09-01

Full Text Available Para conocer la salud de la población es necesario realizar un análisis conjunto y continuado de su estado de salud y de sus determinantes. El objetivo de esta nota de campo es describir el desarrollo y el funcionamiento de la herramienta Infobarris, que permite visualizar una amplia batería de indicadores y determinantes de la salud de la población de la ciudad de Barcelona según el barrio de residencia. Para el desarrollo de Infobarris se ha usado una metodología ágil que permite el desarrollo de un proyecto de forma iterativa e incremental en etapas: selección de indicadores, diseño del prototipo, desarrollo de la herramienta de visualización, carga de datos, revisión y mejora de la herramienta. Infobarris permite la visualización interactiva de 64 indicadores de salud y de sus determinantes, mediante gráficos, mapas y tablas, lo que facilita la vigilancia de la salud y de sus determinantes en los barrios de la ciudad de Barcelona.

Improvement in the efficiency of amorphous silicon solar cells utilizing the optical confinement effect by means of a TiO2/Ag/SUS back-surface reflector

Energy Technology Data Exchange (ETDEWEB)

Okamoto, H; Hamakawa, Y

1984-05-01

A trial to improve the conversion efficiency of amorphous silicon (a-Si) solar cells was carried out utilizing the optical confinement effect for low energy photons near the optical band edge. For this purpose a TiO2/Ag/SUS (where SUS represents high grade mirror etched stainless steel) highly reflective semitextured substrate acting as a light scatterer was developed. Inverted-type a-Si solar cells fabricated on this substrate exhibit a remarkable increase in the carrier collection efficiency in the spectral region just above the optical energy gap of a-Si. The increase in J(sc) was about 20 percent compared with that of a cell on a conventional SUS substrate. Using this substrate, a conversion efficiency of more than 9 percent was attained. 16 references.

4s24p3--4s4p4 and 4s24p3--4s2fp25s transitions in Y VII, Zr VIII, Nb IX, and MoX

International Nuclear Information System (INIS)

Reader, J.; Acquista, N.

1981-01-01

Spectra of ionized Y, Zr, Nb, and Mo have been observed in sliding-spark and triggered-spark discharges on 10.7-m normal- and grazing-incidence spectrographs at the National Bureau of Standards in Washington, D. C. From these observations the 4s 2 4p 3 --4s4p 4 transitions in Y VII, Zr VIII, Nb IX, and Mo X have been identified. The 4s 2 4p 3 --4s 2 4p 2 5s transitions in Y VII-Mo X, previously identified by Rahimullah et al. [Phys. Scr. 14, 221--223 (1976); 18, 96--106 (1978)], have been confirmed. In Y VII the 4s 2 4p 3 --4s 2 4p 2 6s and 4s4p 4 --4p 5 transition also have been found. The parameters obtained from least-squares fits to the energy levels are compared with Hartree--Fock calculations. Preliminary values of the ionization energies have been determined as 110.02 +- 0.15 eV for Y VII, 133.7 +- 0.5 eV for Zr VIII, 159.2 +- 0.7 eV for Nb IX, and 186.4 +- 1.2 eV for Mo X

Anatomía del raquis, sus curvas y su control ortostático

OpenAIRE

Aurnague, Jaqueline; Fernández, Hernán

2013-01-01

Nos decidimos a realizar la siguiente ponencia, para analizar y reconocer aquellos aspectos anatómicos y funcionales de la columna vertebral o raquis en relación a sus curvas fisiológicas y a su control ortostatico. El abordaje que efectuaremos, es teniendo en cuenta los contenidos que constantemente estabilizan y desestabilizan el raquis en los movimientos de la vida cotidiana, como también aquellos enfocados en la actividad física en relación a la postura y a su tonicidad. Analizaremos l...

Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models

Science.gov (United States)

Siner, Joshua I.; Samelson-Jones, Benjamin J.; Crudele, Julie M.; French, Robert A.; Lee, Benjamin J.; Zhou, Shanzhen; Merricks, Elizabeth; Raymer, Robin; Camire, Rodney M.; Arruda, Valder R.

2016-01-01

Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645–1648) in the design of B-domain–deleted FVIII (FVIII-BDD) products in current clinical use and in the drug development pipeline, as well as in experimental FVIII gene therapy strategies. Here, we report that processing by furin is in fact deleterious to FVIII-BDD secretion and procoagulant activity. Inhibition of furin increases the secretion and decreases the intracellular retention of FVIII-BDD protein in mammalian cells. Our new variant (FVIII-ΔF), in which this recognition motif is removed, efficiently circumvents furin. FVIII-ΔF demonstrates increased recombinant protein yields, enhanced clotting activity, and higher circulating FVIII levels after adeno-associated viral vector–based liver gene therapy in a murine model of severe hemophilia A (HA) compared with FVIII-BDD. Moreover, we observed an amelioration of the bleeding phenotype in severe HA dogs with sustained therapeutic FVIII levels after FVIII-ΔF gene therapy at a lower vector dose than previously employed in this model. The immunogenicity of FVIII-ΔF did not differ from that of FVIII-BDD as a protein or a gene therapeutic. Thus, contrary to previous suppositions, FVIII variants that can avoid furin processing are likely to have enhanced translational potential for HA therapy. PMID:27734034

Las migraciones internacionales y sus efectos económicos en El Salvador

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Rivera Funes, Oscar Francisco

2005-01-01

Full Text Available Se plantearán aspectos relacionados a los flujos migratorios sucedidos en El Salvador, desde la década de los años setentas y cómo se intensificó en el decenio de 1980, como consecuencia del guerra interna. Se utilizaron algunos estudios realizados por el Dr. Segundo Montes de la Universidad Centroamericana Simeón Cañas (UCA, y se determinará hacia donde migraron principalmente esos grupos de población. Luego se tomará de referencia los datos del Banco Central de Reserva de El Salvador (BCR, para conocer cómo han crecido los montos en dólares recibidos a través de las remesas familiares y el impacto que tienen en la economía, comparándolo con otros ingresos que percibe el país como son las exportaciones. Finalmente se plantearán los resultados obtenidos en un estudio realizado por la Asociación Salvadoreña de Investigación y Promoción Económica y Social (ASIPES que tenía como objetivo evaluar el monto de las remesas recibidas por los miembros de las familia salvadoreña e identificar los usos y destinos de esas remesas, sus características y sus alternativas productivas. Cabe mencionar que este estudio se realizó a través de encuestas ejecutadas en los municipios que de acuerdo a la Encuesta de hogares de propósitos múltiples reciben mayores cantidades de remesas familiar. También se evaluará el impacto que tienen las remesas familiares, principalmente en los hogares pobres.

Las creencias sobre obesidad de niños y niñas en edad escolar y las de sus progenitores

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Holst Schumacher, Ileana

2013-05-01

Full Text Available Resumen: El propósito de este artículo es evidenciar, mediante el método etnográfico, las creencias sobre la obesidad de niños y niñas en edad escolar y las de sus progenitores, pertenecientes a una escuela urbana y pública de San José, Costa Rica. Los resultados apuntan hacia las creencias negativas de la niñez respecto a sus pares con obesidad y sus implicaciones psicosociales y afectivas. En relación con los progenitores se señalan las causas y estrategias de control, las implicaciones de la obesidad, referente a enfermedades físicas y emocionales; el papel del hogar y de la escuela en su prevención. Se concluye que los niños y las niñas creen que la obesidad no es una enfermedad, sino una expresión fenotípica, a la cual le dan grado de relatividad o de escala y la consideran no deseable, resultado que concuerda con la de sus progenitores. Las niñas participantes con obesidad expresaron sus posiciones de defensa y molestia, en relación con experiencias burlescas. Al contrario de sus hijos e hijas, la mayoría de los progenitores sí cree que la obesidad es una enfermedad o un problema de salud o de estética. Además, estiman que esta se controla utilizando una dieta saludable y equilibrada, dando consejos sobre las consecuencias físicas y emocionales de la obesidad y ofreciendo modelos de personas saludables. Por lo tanto, los progenitores y el personal docente creen que la escuela poco puede hacer respecto a la alimentación saludable del alumnado, pues el hogar es el lugar que tiene un papel primordial. Abstract: The purpose of this paper is to unveil beliefs about obesity of school children with this condition and those of their parents, in an urban public school in San Jose, Costa Rica. Ethnography was used to describe and understand, in depth, the beliefs toward children with obesity. The results were: children negative beliefs about obesity, its psychological, social and affective consequences, parents beliefs refer

Genotype and phenotype report on patients with combined deficiency of factor V and factor VIII in Iran.

Science.gov (United States)

Karimi, Mehran; Cairo, Andrea; Safarpour, Mohammad M; Haghpanah, Sezaneh; Ekramzadeh, Maryam; Afrasiabi, Abdolreza; Shahriari, Mahdi; Menegatti, Marzia

2014-06-01

Combined factor V (FV) and factor VIII (FVIII) deficiency is a rare autosomal recessive bleeding disorder characterized by mild-to-moderate bleeding. Epistaxis, postsurgical bleeding and menorrhagia are the most common symptoms. The aim of this study is to report the phenotype-genotype characterization carried out in patients affected with combined FV and FVIII deficiency from Iran. A cross-sectional study was conducted in Shiraz Hemophilia Center, southern Iran. Twelve cases, seven men and five women coming from eight families were included in our study after taking consent form. Coagulation activity for all patients was measured. All exons and intron-exon junctions of lectin mannose binding protein 1 (LMAN1) gene and multiple coagulation factor deficiency 2 genes were amplified by PCR, and subsequently sequenced by the Sanger method. Patients[Combining Acute Accent] age ranged from 6 to 59 years mean ± SD: 23.8 ± 15.4 years and median: 22 years. No patient presented with severe bleeding symptom. Only one patient had severe FV and FVIII deficiency (both factor levels stop codon. Larger studies are needed to calculate the correlation between factor levels, genetic and bleeding symptoms.

PENGGUNAAN MIND MAP DIIRINGI MUSIK KLASIK DALAM PEMBELAJARAN MATEMATIKA UNTUK SISWA KELAS VIII SMPN 1 SAWAHLUNTO

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Rezky Ramadhona

2016-06-01

Full Text Available Penelitian ini bertujuan untuk mengetahui apakah motivasi dan hasil belajar belajar matematika siswa kelas VIII SMPN 1 Sawahlunto setelah menggunakan mind map dan musik klasik lebih baik dari sebelum menggunakan mind map dan musik klasik. Jenis penelitian ini adalah penelitian eksperimen dengan menggunakan dua model rancangan yaitu One Group Pretest Posttest Design untuk melihat dampak perlakuan terhadap motivasi belajar dan Randomized Control Group Only Design untuk melihat dampak perlakuan terhadap hasil belajar. Pengumpulan data dalam penelitian ini menggunakan angket dan tes akhir berupa soal essai. Data yang diperoleh dianalisis dengan menggunakan Uji-t. Hasil penelitian menunjukkan bahwa motivasi belajar matematika siswa cenderung meningkat. Jadi disimpulkan bahwa motivasi belajar matematika siswa setelah menggunakan mind map dan musik klasik lebih baik dari pada sebelum menggunakan mind map dan musik klasik. Dari hasil uji hipotesis untuk data hasil belajar pada selang kepercayaan α = 0,05 diperoleh P-value = 0,022. Jadi dapat disimpulkan bahwa hasil belajar matematika siswa yang menggunakan mind map dan musik klasik lebih baik dari hasil belajar matematika siswa yang tidak menggunakan mind map dan musik klasik. Kata Kunci: Mind Map, Musik Klasik DOI: http://dx.doi.org/10.22342/jpm.10.2.3636.87-92

Diagnostic and prognostic value of factor VIII binding antibodies in acquired hemophilia A: data from the GTH-AH 01/2010 study.

Science.gov (United States)

Werwitzke, S; Geisen, U; Nowak-Göttl, U; Eichler, H; Stephan, B; Scholz, U; Holstein, K; Klamroth, R; Knöbl, P; Huth-Kühne, A; Bomke, B; Tiede, A

2016-05-01

Essentials Factor VIII (FVIII) binding IgG detected by ELISA could be an alternative to the Bethesda assay. We studied the performance of anti-FVIII IgG ELISA in patients with acquired hemophilia and controls. Anti-FVIII IgG > 99th percentile of controls was highly sensitive and specific. Patients with high anti-FVIII IgG have a lower chance of achieving remission. Background Acquired hemophilia A is a severe bleeding disorder that requires fast and accurate diagnosis as it occurs often unexpectedly in previously healthy men and women of every age. The Nijmegen-modified Bethesda assay is the diagnostic reference standard for detecting neutralizing autoantibodies against factor VIII (FVIII), but is not widely available, not ideal for quantifying the complex type 2 inhibitors seen in acquired hemophilia, and suffers from high inter-laboratory variability. Objectives To assess the diagnostic and prognostic value of FVIII-binding antibodies as detected by ELISA compared with the Nijmegen Bethesda assay. Methods Samples from the time of first diagnosis and clinical data were available from 102 patients with acquired hemophilia enrolled in the prospective GTH-AH 01/2010 study. Controls (n = 102) were matched for gender and age. Diagnostic cut-offs were determined by receiver-operator curve analysis. The prognostic value was assessed in 92 of the 102 patients by Cox regression analysis of time to partial remission. Results Anti-FVIII IgG above the 99th percentile (> 15 arbitrary units per mL) revealed high sensitivity and specificity (both 0.99; 95% confidence interval, 0.95-1.0) for diagnosing acquired hemophilia. The likelihood of achieving partial remission was related to anti-FVIII IgG concentration ( 1050, 0.39). The Bethesda titer was only associated with the likelihood of partial remission when analyzed in the central laboratory, but not when data from local GTH study sites were used. Conclusion Although the Nijmegen-modified Bethesda assay is the reference

Tartaglia’s science of weights and mechanics in the sixteenth century selections from quesiti et inventioni diverse books VII–VIII

CERN Document Server

Pisano, Raffaele

2016-01-01

This book presents a historical and scientific analysis as historical epistemology of the science of weights and mechanics in the sixteenth century, particularly as developed by Tartaglia in his Quesiti et inventioni diverse, Book VII and Book VIII (1546; 1554). In the early 16th century mechanics was concerned mainly with what is now called statics and was referred to as the Scientia de ponderibus, generally pursued by two very different approaches. The first was usually referred to as Aristotelian, where the equilibrium of bodies was set as a balance of opposite tendencies to motion. The second, usually referred to as Archimedean, identified statics with centrobarica, the theory of centres of gravity based on symmetry considerations. In between the two traditions the Italian scholar Niccolò Fontana, better known as Tartaglia (1500?–1557), wrote the treatise Quesiti et inventioni diverse (1546). This volume consists of three main parts. In the first, a historical excursus regarding Tartaglia’s lifetime,...

O PalhaSUS e a Saúde em Movimento nas Ruas: relato de um encontro

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Marcus Vinicius Campos Matraca

2014-12-01

Full Text Available Relatamos a experiência gerada pelo encontro entre os projetos PalhaSUS e Estratégia Saúde da Família para População em Situação de Rua (ESF POP RUA, identificando (i sua afinidade metodológica com a Educação Popular em Saúde e (ii a singularidade do território de atuação, a rua, ambiente propício para esse casamento. O encontro foi mediado, por um lado, pela Coordenação de Saúde da Família e pelo Núcleo de Cultura, Ciência e Saúde, da Secretária Municipal de Saúde e Defesa Civil do Rio de Janeiro, e, por outro lado, pelo PalhaSUS desenvolvido no Instituto Oswaldo Cruz, introduzido no processo formativo da primeira equipe da ESF POP RUA. Após as atividades, os agentes de saúde assumiram um segundo papel, como palhaços mediadores da promoção da saúde com alegria, confirmando o potencial de integração da Dialogia do Riso nas ações e políticas de combate à miséria.

SUS 321 HTB boiler tubing with fire grained internal surface resistant to steam-induced oxidation

International Nuclear Information System (INIS)

Kanero, Takahiro; Minami, Yuusuke; Kodera, Toshihide

1981-01-01

Considerable amount of scale is produced by high temperature steam on the austenitic stainless steel tubes used for the superheaters and reheaters of large boilers for power generation. The scale of outer layer separates off due to the thermal stress at the time of starting-up and stopping, and causes the blocking of pipes and the erosion of turbine blades. Following the increase of nuclear power generation, large boilers are used for medium load, accordingly it is expected that the troubles like these increase. In this paper, the manufacturing method and the properties of SUS 321 HTB with fine grain internal surface are reported, which was developed to reduce the rate of growth of scale and to prevent the separation of scale. In order to prevent the separation of scale from austenitic stainless steel tubes, the reduction of scale thickness, surface treatment such as chrome plating, the use of alloys with excellent oxidation resistance, the formation of chrome-rich film rapidly, the heat treatment of cold-worked tubes and so on were carried out. The nitrification of SUS 321 H steel brought about two-phase structure of the fine grain internal surface with excellent oxidation resistance and the rest of coarse grains with high creep strength. (Kako, I.)

THE INFLUENCE OF AUTOLYSIS ON THE PROTEIN-PEPTIDE PROFILE OF Bos taurus AND Sus scrofa HEART AND AORTA TISSUES

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I. M. Chernukha

2016-01-01

Full Text Available The article presents the results of autolytic processes impact on the protein-peptide profile of Bos taurus and Sus scrofa cardiac muscle and aorta. The results of tissue-specific protein identification are also presented as well as the effect of autolysis. Apolipoprotein A-1 involved in the formation of high-density lipoproteins, peroxiredoxin-1 involved in the suppression of oxidative stress, galectin-1 induced apoptosis of T-lymphocytes, as well as number of heat shock proteins with molecular weight less than 30 kDa were identified in Sus scrofa aorta tissue. It was discovered that functional proteins with molecular weight less than 30 kDa are retained during the freezing process, but destroyed under the action of autolytic enzymes. This work was supported by the Russian Science Foundation (project No. 16–16–10073.

A COMISSÃO NACIONAL DE INCORPORAÇÃO DE TECNOLOGIAS NO SUS: UM BALANÇO DOS PRIMEIROS ANOS DE ATUAÇÃO

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Roberta Buarque Rabelo

2015-10-01

Full Text Available O Sistema Único de Saúde (SUS foi criado com o objetivo de oferecer à sociedade brasileira o acesso universal, integral e gratuito aos serviços de saúde. A integralidade é um dos temas que mais despertam polêmica no contexto das avaliações e uso das novas tecnologias no SUS. Em resposta a um movimento iniciado em 2009, visando à adoção de medidas imediatas para o aumento da transparência no processo de avaliação das tecnologias em saúde e a instituição de procedimentos para acompanhar a sua evolução, foi instituída, por lei federal, a Comissão Nacional de Incorporação de Tecnologias no SUS (CONITEC. Assim, a Avaliação de Tecnologias em Saúde (ATS foi institucionalizada no Brasil como processo obrigatório e indispensável para a tomada de decisão sobre a incorporação tecnológica no SUS. Este artigo é um relato de experiência, que descreve dados relacionados à atuação da CONITEC desde a sua implantação. O trabalho desenvolvido por essa comissão reflete o compromisso com o acesso integral e equânime assumido pela sociedade brasileira na Constituição de 1988, sendo um passo decisivo para os direitos sociais e para uma sociedade mais justa e comprometida com o acesso à saúde e com o conhecimento a serviço da população.

Don Quijote y los eruditos: Sobre una polémica crítica y sus implicaciones metacríticas

OpenAIRE

Pardo García, Pedro Javier

2000-01-01

[ES]Este trabajo trata sobre Don Quijote y los eruditos: una polémica crítica y sus implicaciones metacríticas. [EN]This paper deals with Don Quixote and scholars: a critical controversy and its implications metacritica.

Percepción de estudiantes con discapacidad visual sobre sus competencias digitales en una universidad pública del sureste de México

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Silvia Patricia Aquino Zúñiga

2016-04-01

Full Text Available En este artículo nuestro objetivo fue indagar la percepción de estudiantes universitarios con discapacidad visual (ECDV acerca del desarrollo de sus competencias digitales. Participaron en el estudio los diez ECDV inscritos en programas de licenciatura en el ciclo 2014-02. Evaluamos el avance que perciben los estudiantes en competencias digitales relacionadas con el aprendizaje social y colaborativo, la búsqueda y tratamiento de la información, el desarrollo de relaciones interpersonales en el contexto universitario, y el uso de herramientas virtuales y de comunicación social de la universidad. Los resultados sugieren que, a excepción de aquellas referentes a las relaciones interpersonales, los ECDV perciben poco adelanto en sus competencias digitales. Con una prueba Anova de medidas repetidas, determinamos que la percepción de los ECDV sobre las competencias digitales concernientes a las relaciones interpersonales es significativamente mayor que la que reportan en las otras competencias. Concluimos que los ECDV no perciben una mejora en sus competencias digitales, en particular las de aprendizaje social y colaborativo, así como el uso de herramientas digitales.

Electrochemical polarization behavior of sensitized SUS 304 stainless steel in high temperature water

Energy Technology Data Exchange (ETDEWEB)

Kushiya, K [Tohoku Univ., Sendai (Japan); Sugimoto, K; Ejima, T

1978-11-01

Anodic polarization curves for a solution-treated or sensitized SUS 304 stainless steel and solution-treated Fe-Ni-Cr ternary alloys containing 10%Ni and 6 to 14%Cr have been measured in deaerated 0.5 mol/l Na/sub 2/SO/sub 4/ solutions of pH 2.0 to 5.9 at 298, 523 and 553 K. Corrosion potentials for U-bend SCC test specimens of sensitized SUS 304 stainless steel have also been monitored for a long time in the same solutions as those used for the polarization measurements except that they were aerated. It was found that the differences in the current densities in the passive state, i sub(pass), between the solution treated steel and the sensitized one and also between the ternary alloy with higher Cr content and the one with lower Cr content become large with increasing temperature and decreasing pH. This means that the difference in the values of i sub(pass) between grain bodies and Cr-depleted zones along grain boundaries of sensitized steel becomes larger and susceptibility to intergranular corrosion of the sensitized steel in the passivation region becomes higher with increasing temperature and decreasing pH. Since corrosion potentials for the U-bend SCC test specimens in air-satulated solutions lie in the passive region of anodic polarization curves for the sensitized steel in deaerated solutions, the intergranular stress-corrosion cracking of the sensitized steel in high temperature water with dissolved oxygen is considered to be caused by the preferential corrosion in the Cr-depleted zone.

The effect of magnetite on corrosion of stainless steel (SUS309S) in deaerated synthetic sea water

International Nuclear Information System (INIS)

Taniguchi, N.; Honda, A.

1999-10-01

The assessment of lifetime of carbon steel overpack needs to clear the effects of corrosion products on the corrosion rate of carbon steel. It is reported that the corrosion of carbon steel was accelerated under the presence of magnetite as simulated corrosion products. Therefore, it is important to clear the mechanism of the acceleration of corrosion under the presence of magnetite. If carbon steel overpack will not be able to avoid the acceleration of corrosion under repository condition, some countermeasures have to be taken. One of the countermeasures against the effect of magnetite is considered to be the addition of alloying elements to a steel. The immersion test of stainless steel (SUS309S) as the extreme case of alloying was conducted under the presence of magnetite on the metal surface in synthetic sea water. As the result of this test, the corrosion of stainless steel (SUS309S) was not accelerated by the presence of magnetite. Therefore, it is expected that the susceptibility to the effect of magnetite is able to be reduced by addition of alloying elements to a steel. (author)

Rancang Bangun Perangkat Eksperimen Hukum Archimedes untuk MTs LB/A Yaketunis Kelas VIII

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Rofiqoh Utami

2014-06-01

Full Text Available Blind students find difficulties whenever they are involved in the experiment of Archimedes principle as it requests an active visual role. Thus, it is very important to design a special tool for blind students so their practice of Archimedes principle become easier. This paper discusses a research finding which is an innovation of adaptive tools for blind students, such as beaker glass with Braille number, dynamometer with modification and Braille number (Braille Spring Balance and recording lesson about Archimedes principle. This research done for students MTs LB / A Yaketunis Class VIII which aims at analyzing the quality of each tool by media experts, lesson experts, and physics teacher of MTs LB/A.This research is R & D with procedural models adapted from the development of the 4-D models, namely Define, Design, Develop, and Disseminate. According to media expert assessment, beaker glass with Braille number and Braille spring balance has a very good quality with percentage of their respective 100% of the ideal score, while the assessment by lesson experts for each tool have a good quality with percentage 80% and 73.33% of the ideal score, and physics teacher of MTs LB / A assessment for each tool have a very good quality with percentage 100%. According to the media and lesson experts, the recording lesson about Archimedes principle have a good quality with percentage 80% of the ideal score, according to physics teacher MTs LB / A, the recording tool has excellent quality either with percentage 91.82% of the ideal score. This research recommends the blinds students to utilize these innovative-adaptive tools which will enable them appropriately practice Archimedes principle as non-blind students.