WorldWideScience

Sample records for sus cruzas viii

  1. Alfonso VIII, Cruzada y Cristiandad = Alfonso VIII, Crusade and Christendom

    Directory of Open Access Journals (Sweden)

    Carlos de Ayala Martínez

    2016-06-01

    Full Text Available Lacruzada fue el cauce más directo para la integración de la Península Ibérica en el conjunto de la Cristiandad. Este hecho se pone especialmente de relieve cuando nos acercamos al reinado de Alfonso VIII de Castilla. El monarca, que casó con la hija del rey de Inglaterra, comprometió el matrimonio de su primogénita con el heredero del emperador alemán y casó a otra de sus hijas con el futuro rey de Francia, representa esa plena integración cuyo seguimiento es posible a través de diversos indicadores –políticos, ideológicos, culturales…-, que, en todo caso, refuerzan la imagen propagandística de un rey al servicio de la defensa de la Cristiandad.Crusading was the most effective method of integrating the Iberian Peninsula within Christendom. This fact is most evident when we consider the reign of Alfonso VIII of Castile. This monarch married the daughter of the king of England, arranged the marriage of his eldest daughter with the heir of the German Emperor and married another of his daughters with the future king of France. These actions convey the need for maximum integration which can be traced using several indicators –political, ideological, cultural...– that moreover reinforce the propaganda image of a king at the service and in defence of Christianity.

  2. Enhancing organizational capacity to provide cancer control programs among Latino churches: design and baseline findings of the CRUZA Study.

    Science.gov (United States)

    Allen, Jennifer D; Torres, Maria Idali; Tom, Laura S; Rustan, Sarah; Leyva, Bryan; Negron, Rosalyn; Linnan, Laura A; Jandorf, Lina; Ospino, Hosffman

    2015-04-09

    Faith-based organizations (FBOs) have been successful in delivering health promotion programs for African Americans, though few studies have been conducted among Latinos. Even fewer have focused on organizational change, which is required to sustain community-based initiatives. We hypothesized that FBOs serving Latinos would be more likely to offer evidence-based strategies (EBS) for cancer control after receiving a capacity enhancement intervention to implement health programs, and designed the CRUZA trial to test this hypothesis. This paper describes the CRUZA design and baseline findings. We identified Catholic parishes in Massachusetts that provided Spanish-language mass (n = 65). A baseline survey assessed organizational characteristics relevant to adoption of health programs, including readiness for adoption, "fit" between innovation and organizational mission, implementation climate, and organizational culture. In the next study phase, parishes that completed the baseline assessment will be recruited to a randomized cluster trial, with the parish as the unit of analysis. Both groups will receive a Program Manual and Toolkit. Capacity Enhancement parishes will also be offered technical support, assistance forming health committees and building inter-institutional partnerships, and skills-based training. Of the 49 parishes surveyed at baseline (75%), one-third (33%) reported having provided at least one health program in the prior year. However, only two program offerings were cancer-specific. Nearly one-fifth (18%) had an active health ministry. There was a high level of organizational readiness to adopt cancer control programs, high congruence between parish missions and CRUZA objectives, moderately conducive implementation climates, and organizational cultures supportive of CRUZA programming. Having an existing health ministry was significantly associated with having offered health programs within the past year. Relationships between health program

  3. Cuando el VIH se cruza en el camino del embarazo: dolor, incertidumbre y miedos

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    Yurian Lida Rubiano Mesa

    Full Text Available Recibir un diagnóstico de VIH durante la gestación es un evento traumático y que envuelve un proceso feliz y deseado, en uno doloroso, angustiante, lleno de miedos y medicalizado. También encierra a la mujer en un mar de incertidumbre por su futuro y el de su hijo. Este es el relato biográfico de una joven mujer que describe sus experiencias al enfrentarse al diagnóstico de VIH durante su primera gestación. A partir de este momento, su narrativa describe la discriminación y estigmatización por parte de los profesionales de la salud, la lucha diaria para tolerar los medicamentos y el miedo por la salud de su hija. Las implicaciones de la enfermedad en su vida como mujer y como madre también emergen en su relato, así como la fe en Dios, el apoyo de su madre y el amor hacia su hija como apoyos para enfrentar el VIH.

  4. DESPANOJADO Y DENSIDAD DE POBLACIÓN EN UNA CRUZA SIMPLE ANDROESTÉRIL Y FÉRTIL DE MAÍZ

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    Alejandro Espinosa-Calder\\u00F3n

    2010-01-01

    Full Text Available En este trabajo el objetivo fue determinar el efecto del despanojado en la productividad de cruzas simples de maíz. Se estableció un experimento durante el ciclo primavera - verano 2004, en el Rancho Almaraz de la Facultad de Estudios Superiores Cuautitlán, de la Universidad Nacional Autónoma de México (FESC-UNAM, ubicado en Cuautitlán Izcalli, México, a 2240 msnm. Se utilizó un diseño experimental de campo en bloques completos al azar con tres repeticiones, el análisis estadístico se efectuó en forma factorial, considerando los factores genotipos (2, densidades de población (3 y el tratamiento de despanojado y sin despanojar (2, así como las interacciones. El rendimiento tuvo diferencias altamente significativas para despanojado, así como significancia estadística para genotipos y densidad de población y la interacción densidad de población x despanojado. La cruza simple versión androestéril en promedio rindió 8873 kg/ha, superior estadísticamente (17,9% a la versión fértil que produjo 7521 kg/ha. La densidad de población de 80 000 plantas/ha con 9640 kg/ha, superó estadísticamente al rendimiento obtenido con 50 000 plantas/ha (7193 kg/ha. El testigo sin despanojar (9429 kg/ha superó estadísticamente al despanojado.

  5. Cronica descoperirilor monetare (VIII / Chronicle of monetary findings (VIII

    Directory of Open Access Journals (Sweden)

    Ana Boldureanu

    2014-10-01

    Full Text Available The author presents the finds of coins in the historical territory of Moldova, which were recorded during 2013 - the first half of 2014. There were examined three ancient coins and one Byzantine coin found in the Ocniţa District. They were minted under the emperors Septimius Severus (193-211, Maximianus Herculius (286-305 and Decentius (350-353. The Byzantine coin is class A2 anonymous follis issued during the reign of Basil II, Constantine VIII and Roman III (976(?-030/1035. There are presented findings of medieval coins from Bolohani, Orhei, Brătuleni (Nisporeni District, Hincăuţi, Edineţ, Lăpuşna, Hânceşti, Oprişeni (Glyboka District, Chernivtsi region of Ukraine, Zguriţa (Ocniţa District etc. All of them will complete the list of coin finds from Moldova and provide researchers new documentary sources.

  6. 12 CFR 611.1137 - Title VIII service corporations.

    Science.gov (United States)

    2010-01-01

    ... Organizations § 611.1137 Title VIII service corporations. (a) What is a title VIII service corporation? A title VIII service corporation is a service corporation organized for the purpose of exercising the... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Title VIII service corporations. 611.1137...

  7. Physicochemical characterisation of rVIII-SingleChain, a novel recombinant single-chain factor VIII.

    Science.gov (United States)

    Schmidbauer, Stefan; Witzel, Reinhild; Robbel, Lars; Sebastian, Petra; Grammel, Nicolas; Metzner, Hubert J; Schulte, Stefan

    2015-08-01

    rVIII-SingleChain is a novel recombinant single-chain factor VIII (FVIII) construct, comprising covalently bonded heavy and light chains. Post-translational modifications of FVIII affect physicochemical parameters, including hydrophobicity and charge. The most relevant post-translational modifications of FVIII products are N-glycosylation of asparagine residues and tyrosine sulphations. Here, the physicochemical properties, thrombin cleavage products and post-translational modifications of rVIII-SingleChain were investigated and compared against commercially available recombinant FVIII (rFVIII) products with a predominant two-chain structure (B-domain deleted rFVIII and full-length rFVIII). rVIII-SingleChain was expressed in Chinese hamster ovary (CHO) cells and purified by chromatographic methods. Physicochemical properties of rVIII-SingleChain or thrombin-derived cleavage products were assessed using size-exclusion chromatography, reversed-phase chromatography and sodium dodecyl sulphate polyacrylamide gel electrophoresis. Analysis of the respective carbohydrate structures was performed after release of N-glycans by PNGase F followed by fluorescence labelling and high-performance liquid chromatography. Proteolysis by trypsin generated the corresponding peptides, which were analysed for sulphated tyrosines by liquid chromatography-electrospray ionisation time of flight-mass spectrometry. rVIII-SingleChain was shown to be of high purity and homogeneity, and presented a well-defined single-chain molecule with predominant β-sheet conformation. The coagulation-relevant thrombin-activation products of rVIII-SingleChain were comparable with those obtained by activation of commercially available rFVIII products. rVIII-SingleChain post-translational modifications were similar to other CHO cell-derived rFVIII products for N-glycopattern and tyrosine sulphation. In conclusion, rVIII-SingleChain is of high homogeneity and purity, and provides an expected cleavage pattern on

  8. 77 FR 64401 - Order of Succession for HUD Region VIII

    Science.gov (United States)

    2012-10-19

    ... Region VIII AGENCY: Office of Field Policy and Management, HUD. ACTION: Notice of Order of Succession... Field Offices (Region VIII). This Order of Succession supersedes all previous Orders of Succession for HUD Region VIII. DATES: Effective Date: October 9, 2012. FOR FURTHER INFORMATION CONTACT: Lawrence D...

  9. Blood coagulation factor VIII: An overview

    Indian Academy of Sciences (India)

    Factor VIII (FVIII) functions as a co-factor in the blood coagulation cascade for the proteolytic activation of factor X by factor IXa. Deficiency of FVIII causes hemophilia A, the most commonly inherited bleeding disorder. This review highlights current knowledge on selected aspects of FVIII in which both the scientist and the ...

  10. Blood coagulation factor VIII: An overview

    Indian Academy of Sciences (India)

    Unknown

    Santagostina E and Castaman G 2001 TT virus contaminates first generation recombinant factor VIII concentrates; Blood. 98 2571–2573. Azzi A, Morfini M and Mannucci P M 1999 The transfusion associated transmission of parvovirus B19; Transfus. Med. Rev. 13 194–204. Bowen D J 2002 Haemophilia A and Haemophilia ...

  11. Formación de híbridos de maíz de cruza múltiple partiendo de híbridos comerciales Formación de híbridos de maíz de cruza múltiple partiendo de híbridos comerciales

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    Oscar Alejandro Martínez-Jaime

    2012-02-01

    Full Text Available The aim of this research was getting information about thirty experimental hybrids of maize, all of them multiple crosses from commercial hybrids as parents. Hybrids were sown field on three locations: El Llanito, San Antonio and Marquez which belong to Irapuato, Gto., Mexico. Lattice 7 x 7 were used as experimental design and combined analysis and stability parameters models for comparing varieties through environments. Besides, seven characters were evaluated: plant height, ear height, ear length, percent of blow over, percent of double ear and grain yield. Results indicated the following: Response all maize genotypes is not similar across over environments and locations amongst themselves. In Fact multiple crosses as Leon x Tigre, Lince x Leon, 30G54 x Leon, 30G45 x Tigre y Aspros-948 x Tigre were stables genotypes for seven characters above all grain yield, however Lince x Tigre y DK-2002 x Leon had good response for not favourable conditions and favourable conditions. Commercial hybrids as Oso, Aspros-900, DK-2020, DK-2000, Bida-33, Bida-55 and DK-2002 result out standing for grain yield and were: 11.12 t/ha, 10.81 t/ha, 10.63 t/ha, 10.11 t/ha, 9.78 t/ha, 9.77 t/ha y 9.47 t/ha, whereas DK-2020 was defined as hybrid has good response for not favourables environments. The most important it indicates that DK-2002 x Leon hybrid was defined as good as the best hybrid: Oso, Aspros-900 and DK-2020. Finally, farmers can use this technology to produce seeds beginning with commercial hybrids seeds. El objetivo de este trabajo fue obtener y comparar 30 híbridos experimentales de maíz de cruza múltiple provenientes de híbridos comerciales que fungieron como progenitores. Se establecie­ron ensayos de rendimiento en las localidades: El Llanito, San Antonio y Márquez, municipio de Irapuato, Gto., México, en diseños látice simple 7 x 7. Los materiales se evaluaron en forma conjunta y se analizaron por estabilidad de rendimiento para seis car

  12. Composición de leche de vacas Criollo, Guzerat y sus cruzas F1 y su relación con el peso al destete de las crías

    Directory of Open Access Journals (Sweden)

    Guillermo Martínez Velázquez

    2010-01-01

    Full Text Available Se utilizaron 619 registros productivos generados entre 2001 y 2003 por vacas Guzerat (G, Criollo (C, Guzerat x Criollo (GC y Criollo x Guzerat (CG. Las variables estudiadas fueron porcentaje de grasa (%G, proteína (%P, lactosa (%L y sólidos no grasos (%SNG contenidos en la leche y kilogramos de grasa (GP, proteína (PP, lactosa (LP y sólidos no grasos (SNGP producidos por lactancia. También se evaluaron peso al nacer (PN y peso al destete ajustado a 210 días de edad (PA210 y se estimaron efectos genéticos directos, maternos, de heterosis y la relación entre componentes de la leche y PA210. Para %G, %P, %L, %SNG, GP, PP, LP y SNGP los modelos incluyeron los efectos fijos de grupo genético de la vaca (GEN, número de parto (NP, año de parto (A, época de parto (E, días posparto (D e interacciones de dos factores (F. Para PN y PA210 los modelos incluyeron GEN, NP, A, E y F. Se estimaron correlaciones residuales entre componentes de la leche y PA210. Heterosis fue importante (P<0.05 para GP (5.07+1.9 kg, PP (4.97+1.5 kg, LP (7.04+2.1 kg, SNGP (13.48+3.8 kg, PN (-1.30+0.6 kg y PA210 (12.65+4.2 kg. Los efectos genéticos directos para LP, SNGP, PN y PA210 fueron favorables (P<0.05 a G en 11.08+3.7, 16.98+6.6, 3.80+1.1 y 37.60+7.6 kg. Se detectaron correlaciones importantes (P<0.05 de PA210 con GP (0.16, LP (0.21 y SNGP (0.19. Las correlaciones sugieren que la cantidad de componentes en la leche fue importante para determinar el peso al destete de los becerros.

  13. Preparing for ENDF/B-VIII

    Science.gov (United States)

    Brown, David

    2017-09-01

    Although the next major release of the ENDF/B library is not due until the 2017-2018 time frame, ENDF/B-VIII is already positioned to become the most important release of the library in some time. ENDF/B-VIII will be built around the Neutron Reaction Standards as well as the 1H, 16O, 56Fe, 235U, 238U and 239Pu evaluations developed as part of the Coordinated International Evaluation Library Organization (CIELO) pilot project. In this contribution, we summarize these improvements as well as the many other improvements to ENDF that have already been made or are scheduled to be made in the next year. Improvements already included in the ENDF/B-VIII beta releases: • Aggressive use of the flexible and physically correct LRF=7 resolved resonance format in 12 updated evaluations (35,37Cl, 40Ca, 54,56,57Fe, 63,65Cu and 182,183,184,186W) • Thermal capture gammas from the EGAF project (6,7Li, 11B, 19F, 23Na, 27Al, 28Si, 35,37Cl) • Thermal Scattering Law evaluations from NCSU (α and β phase SiO2, SiC, lucite, BeO, and polyethylene) and from the CAB-CNL collaboration (heavy and light water) • Many new evaluations in the neutron sublibrary (n, 12,13C, 40Ar, 54,57,58Fe, 58,59,60,61,62,64Ni, 63,65Cu, 73As, 120Sn, 236m1Np) Inclusion of Red Cullen's EPICS2014 library, updating the photo-atomic, electron and atomic-relaxation sublibraries. Many improvements are planned in the next year including new evaluations such as charged particle evaluations translated from LLNL's ECPL. In addition to these major changes, ENDF/B-VIII will be the first official library released simultaneously in the legacy ENDF-6 and the newly developed Generalized Nuclear Data (GND) formats.

  14. The influence of prophylactic factor VIII in severe hemophilia A

    Science.gov (United States)

    Gissel, Matthew; Whelihan, Matthew F; Ferris, Lauren A; Mann, Kenneth G; Rivard, Georges E; Brummel-Ziedins, Kathleen E

    2013-01-01

    Introduction Hemophilia A individuals displaying a similar genetic defect have heterogeneous clinical phenotypes. Aim To evaluate the underlying effect of exogenous factor (f)VIII on tissue factor (Tf)-initiated blood coagulation in severe hemophilia utilizing both empirical and computational models. Methods We investigated twenty-five clinically severe hemophilia A patients. All individuals were on fVIII prophylaxis and had not received fVIII from 0.25 to 4 days prior to phlebotomy. Coagulation was initiated by the addition of Tf to contact-pathway inhibited whole blood ± an anti-fVIII antibody. Aliquots were quenched over 20 min and analyzed for thrombin generation and fibrin formation. Coagulation factor levels were obtained and used to computationally predict thrombin generation with fVIII set to either zero or its value at the time of the draw. Results Due to prophylactic fVIII, at the time of the blood draw, the individuals had fVIII levels that ranged from hemophilia A. The combination of each individual's coagulation factors (outside of fVIII) determine each individual's baseline thrombin potential and may affect bleeding risk. PMID:21899664

  15. VIII International Meeting on Lorentzian Geometry

    CERN Document Server

    Flores, José; Palomo, Francisco; GeLoMa 2016; Lorentzian geometry and related topics

    2017-01-01

    This volume contains a collection of research papers and useful surveys by experts in the field which provide a representative picture of the current status of this fascinating area. Based on contributions from the VIII International Meeting on Lorentzian Geometry, held at the University of Málaga, Spain, this volume covers topics such as distinguished (maximal, trapped, null, spacelike, constant mean curvature, umbilical...) submanifolds, causal completion of spacetimes, stationary regions and horizons in spacetimes, solitons in semi-Riemannian manifolds, relation between Lorentzian and Finslerian geometries and the oscillator spacetime. In the last decades Lorentzian geometry has experienced a significant impulse, which has transformed it from just a mathematical tool for general relativity to a consolidated branch of differential geometry, interesting in and of itself. Nowadays, this field provides a framework where many different mathematical techniques arise with applications to multiple parts of mathem...

  16. El folklore y sus paradojas

    Directory of Open Access Journals (Sweden)

    HONORIO M. VELASCO MAILLO

    1990-01-01

    Full Text Available Uno de los rasgos más sobresalientes de la historia del folklore en España y otras naciones europeas son sus paradojas. Propuesto primero como ciencia ha llegado a ser claramente rechazado por posteriores ambientes científicos. Tendría interés hacer una historia social del folklore. Este artículo sugiere que tales paradojas y contradicciones están relacionadas con el paradigma científico que asumieron sus promotores, el evolucionismo cultural y con un concepto idealizado de "pueblo", que ayudaron a construir presentando colecciones de materiales. También analiza las diferentes funciones sociales que ha cumplido el discurso folklórico.

  17. AAV5-Factor VIII Gene Transfer in Severe Hemophilia A.

    Science.gov (United States)

    Rangarajan, Savita; Walsh, Liron; Lester, Will; Perry, David; Madan, Bella; Laffan, Michael; Yu, Hua; Vettermann, Christian; Pierce, Glenn F; Wong, Wing Y; Pasi, K John

    2017-12-28

    Patients with hemophilia A rely on exogenous factor VIII to prevent bleeding in joints, soft tissue, and the central nervous system. Although successful gene transfer has been reported in patients with hemophilia B, the large size of the factor VIII coding region has precluded improved outcomes with gene therapy in patients with hemophilia A. We infused a single intravenous dose of a codon-optimized adeno-associated virus serotype 5 (AAV5) vector encoding a B-domain-deleted human factor VIII (AAV5-hFVIII-SQ) in nine men with severe hemophilia A. Participants were enrolled sequentially into one of three dose cohorts (low dose [one participant], intermediate dose [one participant], and high dose [seven participants]) and were followed through 52 weeks. Factor VIII activity levels remained at 3 IU or less per deciliter in the recipients of the low or intermediate dose. In the high-dose cohort, the factor VIII activity level was more than 5 IU per deciliter between weeks 2 and 9 after gene transfer in all seven participants, and the level in six participants increased to a normal value (>50 IU per deciliter) that was maintained at 1 year after receipt of the dose. In the high-dose cohort, the median annualized bleeding rate among participants who had previously received prophylactic therapy decreased from 16 events before the study to 1 event after gene transfer, and factor VIII use for participant-reported bleeding ceased in all the participants in this cohort by week 22. The primary adverse event was an elevation in the serum alanine aminotransferase level to 1.5 times the upper limit of the normal range or less. Progression of preexisting chronic arthropathy in one participant was the only serious adverse event. No neutralizing antibodies to factor VIII were detected. The infusion of AAV5-hFVIII-SQ was associated with the sustained normalization of factor VIII activity level over a period of 1 year in six of seven participants who received a high dose, with

  18. Idiopathic Acquired Hemophilia A with Undetectable Factor VIII Inhibitor

    Directory of Open Access Journals (Sweden)

    Nicholas B. Abt

    2014-01-01

    Full Text Available Objective. We present the case of a 73-year-old female, with no family or personal history of a bleeding disorder, who had a classic presentation for acquired hemophilia A. Factor VIII activity was low but detectable and a factor VIII inhibitor was undetectable. Methods. The patient’s plasma was comprehensively studied to determine the cause of the acquired coagulopathy. Using the Nijmegen modification of the Bethesda assay, no factor VIII autoantibody was measureable despite varying the incubation time from 1 to 3 hours. Results. The aPTT was prolonged at 46.8 seconds, which did not correct in the 4 : 1 mix but did with 1 : 1 mix. Using a one stage factor VIII activity assay, the FVIII activity was 16% and chromogenic FVIII activity was also 16%. The patient was treated with recombinant FVII and transfusion, significantly reducing bleeding. Long-term therapy was initiated with cyclophosphamide and prednisone with normalization of FVIII activity. Conclusions. Physicians can be presented with the challenging clinical picture of an acquired factor VIII inhibitor without a detectable inhibitor by the Bethesda assay. Standard therapy for an acquired hemophilia A should be considered.

  19. VIII International Congress of Engineering Physics

    International Nuclear Information System (INIS)

    2017-01-01

    The Physicist Engineering is a multidisciplinary profession in which an undergraduate student integrates and applies their knowledge of Physics, Mathematics, and Computing to adapt and innovate all kind of technologies, as well as to development and apply theoretical knowledge to different fields of science and engineering. A Physicist Engineer, supported by a solid preparation in science and engineering is available to study, analyze, identify, and solve problems in different fields of science and technology for industries, hospitals, research laboratories, institutes and governmental organizations focused on metrology, optics, energy, materials, instrumentation of sophisticated equipment. The Physicist Engineering bachelor degree is a national and international reference to encouraging all those students to apply knowledge through active participation in the operation, planning, and management of projects. The technological and scientific impact of a Physicist Engineering undergraduate and graduate students, as well as the tutorial of the research professor that are interested in Physics and Physics Engineering, may be found in a biennial event like the International Conference on Physicist Engineering, through the diffusion of both experimental and theoretical research and teaching. In order to promote and encourage strength academic goals among universities and research institutions, the International Conference on Physics Engineering Committee, integrated by a faculty meeting of the Universidad Autónoma Metropolitana, Campus Azcapotzalco, has decided to grant the VIII International Congress of Physics Engineering to the Universidad Autónoma de Yucatán, which is going to take place on Mérida, November 7 th to 11 th , 2016. This conference considers different topics as: Renewables Energies Engineering Materials Technology Nanotechnology Medical Physics Education in Physics Engineering Nuclear Engineering High Precision Instrumentation Atmosphere Physics

  20. The labour ward analgesic service at King Edward VIII Hospital ...

    African Journals Online (AJOL)

    Abstract The provision of analgesic services to the labour ward at King Edward VIII Hospital was studied during a I-week period. Of249 patients, 113 (45%) received no analgesia whatsoever. Intramuscular pethidine was the commonest form of analgesia and was used in 97 patients (39%). Thirty-six patients (14%) received ...

  1. Nijmegen-Bethesda assay to measure factor VIII inhibitors.

    Science.gov (United States)

    Duncan, Elizabeth; Collecutt, Margaret; Street, Alison

    2013-01-01

    Hemophilia A is an inherited bleeding disorder caused by a deficiency of factor VIII coagulant activity (FVIII:C). Patients are treated with infusions of either plasma-derived or recombinant factor VIII. However, some patients develop inhibitory antibodies (inhibitors) to infused factor VIII which render it ineffective. The original Bethesda method was developed to standardize measurement of inhibitors in a factor VIII neutralization assay. One Bethesda unit is defined as that amount of inhibitor that results in 50% residual FVIII:C activity of a defined test mixture. In the Nijmegen modification of the original Bethesda method, the pH and the protein concentration of the test mixture is further standardized. As a result, the FVIII:C in the test mixture is less prone to artifactual deterioration and the test has improved specificity. Even with a standardized procedure a number of factors can affect the performance of the test and it is important for laboratory staff to be aware of their impact on the result outcome.

  2. New study on the XeVIII spectrum

    International Nuclear Information System (INIS)

    Gallardo, M.; Raineri, M.; Giuliani, M.; Lagorio, C.; Padilla, S.; Sarmiento, R.; Reyna Almandos, J.G.

    2005-01-01

    Capillary light sources were used to observe the spectrum of seven-times-ionized xenon, XeVIII, in the 300-6000 A wavelength range. Twenty-eight energy levels belonging to the 5s-9s, 5d-9d, 5g-9g, 7i-10i, 9l, 5p-9p, 4f-9f, 6h-9h and 8k-10k configurations were adjusted and 38 new spectral lines were classified. The XeVIII ionization energy was determined with improved accuracy using the polarization model. The analysis was supported by Hartree-Fock calculations. The weighted oscillator strengths for all the observed spectral lines were also calculated considering the fitted values for the energy parameters

  3. Characterization of five partial deletions of the factor VIII gene

    International Nuclear Information System (INIS)

    Youssoufian, H.; Antonarakis, S.E.; Aronis, S.; Tsiftis, G.; Phillips, D.G.; Kazazian, H.H. Jr.

    1987-01-01

    Hemophilia A is an X-linked disorder of coagulation caused by a deficiency of factor VIII. By using cloned DNA probes, the authors have characterized the following five different partial deletions of the factor VIII gene from a panel of 83 patients with hemophilia A: (i) a 7-kilobase (kb) deletion that eliminates exon 6; (ii) a 2.5-kb deletion that eliminates 5' sequences of exon 14; (iii) a deletion of at least 7 kb that eliminates exons 24 and 25; (iv) a deletion of at least 16 kb that eliminates exons 23-25; and (v) a 5.5-kb deletion that eliminates exon 22. The first four deletions are associated with severe hemophilia A. By contrast, the last deletion is associated with moderate disease, possibly because of in-frame splicing from adjacent exons. None of those patients with partial gene deletions had circulating inhibitors to factor VIII. One deletion occurred de novo in a germ cell of the maternal grandmother, while a second deletion occurred in a germ cell of the maternal grandfather. These observations demonstrate that de novo deletions of X-linked genes can occur in either male or female gametes

  4. The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells.

    Science.gov (United States)

    Gangadharan, Bagirath; Ing, Mathieu; Delignat, Sandrine; Peyron, Ivan; Teyssandier, Maud; Kaveri, Srinivas V; Lacroix-Desmazes, Sébastien

    2017-02-01

    The development of inhibitory antibodies to therapeutic factor VIII is the major complication of replacement therapy in patients with hemophilia A. The first step in the initiation of the anti-factor VIII immune response is factor VIII interaction with receptor(s) on antigen-presenting cells, followed by endocytosis and presentation to naïve CD4 + T cells. Recent studies indicate a role for the C1 domain in factor VIII uptake. We investigated whether charged residues in the C2 domain participate in immunogenic factor VIII uptake. Co-incubation of factor VIII with BO2C11, a monoclonal C2-specific immunoglobulin G, reduced factor VIII endocytosis by dendritic cells and presentation to CD4 + T cells, and diminished factor VIII immunogenicity in factor VIII-deficient mice. The mutation of basic residues within the BO2C11 epitope of C2 replicated reduced in vitro immunogenic uptake, but failed to prevent factor VIII immunogenicity in mice. BO2C11 prevents factor VIII binding to von Willebrand factor, thus potentially biasing factor VIII immunogenicity by perturbing its half-life. Interestingly, a factor VIII Y1680C mutant, that does not bind von Willebrand factor, demonstrated unaltered endocytosis by dendritic cells as well as immunogenicity in factor VIII-deficient mice. Co-incubation of factor VIII Y1680C with BO2C11, however, resulted in decreased factor VIII immunogenicity in vivo In addition, a previously described triple C1 mutant showed decreased uptake in vitro, and reduced immunogenicity in vivo, but only in the absence of endogenous von Willebrand factor. Taken together, the results indicate that residues in the C1 and/or C2 domains of factor VIII are implicated in immunogenic factor VIII uptake, at least in vitro Conversely, in vivo, the binding to endogenous von Willebrand factor masks the reducing effect of mutations in the C domains on factor VIII immunogenicity. Copyright© Ferrata Storti Foundation.

  5. 40 CFR Appendix Viii to Part 600 - Fuel Economy Label Formats

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Fuel Economy Label Formats VIII... POLICY FUEL ECONOMY AND CARBON-RELATED EXHAUST EMISSIONS OF MOTOR VEHICLES Pt. 600, App. VIII Appendix VIII to Part 600—Fuel Economy Label Formats EC01MY92.117 EC01MY92.118 EC01MY92.119 EC01MY92.120...

  6. Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin

    International Nuclear Information System (INIS)

    Hill-Eubanks, D.C.; Parker, C.G.; Lollar, P.

    1989-01-01

    Blood coagulation factor VIII (fVIII) is a plasma protein that is decreased or absent in hemophilia A. It is isolated as a mixture of heterodimers that contain a variably sized heavy chain and a common light chain. Thrombin catalyzes the activation of fVIII in a reaction that is associated with cleavages in both types of chain. The authors isolated a serine protease from Bothrops jararacussu snake venom that catalyzes thrombin-like heavy-chain cleavage but not light-chain cleavage in porcine fVIII as judged by NaDodSO 4 /PAGE and N-terminal sequence analysis. Using a plasma-free assay of the ability of activated 125 I-fVIII to function as a cofactor in the activation of factor X by factor IXa, they found that fVIII is activated by the venom enzyme. The venom enzyme-activated fVIII was isolated in stable form by cation-exchange HPLC. von Willebrand factor inhibited venom enzyme-activated fVIII but not thrombin-activated fVIII. These results suggest that the binding of fVIII to von Willebrand factor depends on the presence of an intact light chain and that activated fVIII must dissociate from von Willebrand factor to exert its cofactor effect. Thus, proteolytic activation of fVIII-von Willebrand factor complex appears to be differentially regulated by light-chain cleavage to dissociate the complex and heavy-chain cleavage to activate the cofactor function

  7. Metilcelulosa: sus aplicaciones farmacéuticas

    OpenAIRE

    Tapia Villanueva, Cristián; Sapag Hagar, Jaime

    1995-01-01

    El objetivo de este trabajo es señalar las propiedades más importantes de la metilcelulosa (MC) y explicar de qué manera éstas son determinadas por sus características físicas y químicas. Además, se discuten algunas de sus aplicaciones más importantes en formulaciones farmacéuticas.

  8. War and peace: Factor VIII and the adaptive immune response.

    Science.gov (United States)

    Georgescu, Maria T; Lai, Jesse D; Hough, Christine; Lillicrap, David

    2016-03-01

    The development of neutralizing anti-factor VIII (FVIII) antibodies (inhibitors) remains a major challenge for FVIII replacement therapy in hemophilia A patients. The adaptive immune response plays a crucial role in the development and maintenance of inhibitors. In this review, we focus on our current understanding of FVIII interactions with cells of the adaptive immune system and the phenotype of the resultant response. Additionally, we examine both current and novel FVIII tolerance induction methods that function at the level of the adaptive immune response. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. PENERAPAN METODE PENEMUAN TERBIMBING DI KELAS VIII SMP

    Directory of Open Access Journals (Sweden)

    Toni Hidayat

    2017-08-01

    Full Text Available This study was a classroom action research which aims to investigate how the implementation of guided discovery learning can improve students’ activeness and attainment in the class VIII of Laboraturium UM Senior High School Malang city. The study subject was Class VIII that consists of 36 students, year 2016/2017. This study consisted of two cycles, and the data was collected from the result of the final test, observation, and interview. Based on the research of cycle I, the students’ activeness with mean scores of the meeting I, II, III was 78.88%, 79%, 86.6% respectively. The students’ activeness on cycle II, the mean scores of analyst meeting V and VI were 89.22% and 92.24% respectively. The result of Mathematics learning was increased, it is shown on the test mean of the cycle I that was achieved by 36 students with the percentage of successful learning 83 %. On the cycle test II, the average of 36 gained 82 (score with 7.2 increased from the score mean of the cycle I and with classical mastery learning cycle II 88.88%. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK yang bertujuan untuk mengetahui bagaimana penerapan metode penemuan terbimbing yang dapat meningkatan keaktifan dan hasil belajar siswa kelas VIII SMP Laboratorium UM Kota Malang. Subjek penelitian ini ialah siswa kelas VIII yang berjumlah 36 siswa tahun pelajaran 2016/2017. Penelitian ini terdiri atas dua siklus dan data dikumpulkan dari hasil tes akhir tindakan, observasi, dan wawancara. Berdasarakan hasil penelitian pada siklus I, keaktifan siswa siswa dengan skor rata-rata pertemuan I, II, III adalah 78,88% 79,%, dan 86,6%. Aktivitas siswa pada siklus II, rata-rata skor pengamat pertemuan V dan VI berturut-turut 89,22 % dan 92,24%. Hasil belajar matematika siswa meningkat, hal ini terlihat bahwa rata-rata tes siklus I yang diperoleh 36 siswa sebesar 74,8 dengan presentase keberhasilan belajar 83,33%. Pada tes siklus II rata-rata nilai menjadi 82 dengan

  10. Aptitud combinatoria y predicción de híbridos de maíz (Zea mays L.) de grano amarillo a partir de cruzas dialélicas, evaluadas en dos localidades de la zona baja de Guatemala, 1989

    OpenAIRE

    Quemé de León, José Luis; Larios Bobadilla, Luis; Pérez Rodas, Carlos; Soto León, Nery

    2016-01-01

    Por la importancia que tiene el maíz de grano amarillo en el crecimiento normal para humanos y animales y con el propósito de incrementar la producción de maíz en Guatemala, el Programa de Maíz del ICTA realizó la presente investigación utilizando 10 líneas en su mayoría con diferente origen genético y cuyo objetivo general planteado es generar cruzas dobles (CD) y de tres líneas (CT) que superen al mejor híbrido comercial HA-46; los objetivos específicos fueron: 1) Estimar los efectos de apt...

  11. Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia a

    NARCIS (Netherlands)

    C.L. Eckhardt (Corien); A.S. van Velzen (Alice); M.A.D. Peters (Marjolein); J. Astermark (Jan); P.P. Brons; G. Castaman (Giancarlo); M.H. Cnossen (Marjon); N. Dors (N.); C. Escuriola-Ettingshausen (Carmen); K. Hamulyák (K.); D.P. Hart (Daniel); C.R.M. Hay (Charles R.); S. Haya (Saturnino); W.L. van Heerde; C. Hermans (Cédric); M. Holmström (Margareta); V. Jimenez-Yuste (Victor); R.D. Keenan (Russell); R. Klamroth (Robert); B.A.P. Laros-Van Gorkom (Britta); F.W.G. Leebeek (Frank); R. Liesner (Ri); A. Mäkipernaa (Anne); C. Male (Christoph); E.P. Mauser-Bunschoten (Eveline); M.G. Mazzucconi (Maria); S. McRae (Simon); K. Meijer (K.); M. Mitchell (Michael); M. Morfini (Massimo); M.R. Nijziel (Marten); J. Oldenburg (Jan); K. Peerlinck; P. Petrini (Pia); H. Platokouki (Helena); S.E. Reitter-Pfoertner (Sylvia); E. Santagostino (Elena); P. Schinco (Piercarla); F.J.W. Smiers (Frans); K.D. Siegmund (Kimberly); A. Tagliaferri (Annarita); T.T. Yee (Thynn); P.W. Kamphuisen (Pieter Willem); J.G. van der Bom (Anske); K. Fijnvandraat

    2013-01-01

    textabstractNeutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern. Identification of high-risk patients is hampered by lack of data that take exposure days to therapeutic factor VIII concentrates into

  12. Effectiveness of Mind Mapping in English Teaching among VIII Standard Students

    Science.gov (United States)

    Hallen, D.; Sangeetha, N.

    2015-01-01

    The aim of the study is to find out the effectiveness of mind mapping technique over conventional method in teaching English at high school level (VIII), in terms of Control and Experimental group. The sample of the study comprised, 60 VIII Standard students in Tiruchendur Taluk. Mind Maps and Achievement Test (Pretest & Posttest) were…

  13. Phage display technology: a tool to explore the diversity of inhibitors to blood coagulation factor VIII

    NARCIS (Netherlands)

    Voorberg, J.; van den Brink, E. N.

    2000-01-01

    Hemophilia A is a X-linked bleeding disorder that is caused by the functional absence of blood coagulation factor VIII. The bleeding tendency in hemophilia A patients can be corrected by the administration of plasma-derived or recombinant factor VIII concentrates. A serious complication in

  14. Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence

    NARCIS (Netherlands)

    van Kuilenburg, A. B.; Muijsers, A. O.; Demol, H.; Dekker, H. L.; van Beeumen, J. J.

    1988-01-01

    Subunit VIII was purified from a preparation of the human heart cytochrome c oxidase and its complete amino acid sequence was determined. The sequence proved to be much more related to that of the bovine liver oxidase subunit VIII than to that found in bovine heart. Our finding of a 'liver-type'

  15. Paducah-Louisville Consortium; Project VIII: Focus on Dropouts... a New Design. Final Evaluation Report.

    Science.gov (United States)

    Paducah Public Schools, KY.

    Project VIII is an innovative behavioral science oriented educational program, funded under Title VIII Elementary Secondary Education Act, designed to attack the personal, social, and educational problems of children whose previous record of school failure and frustration has indicated high dropout potential. The program is operated as a…

  16. 4p-5s transitions in YVII, VIII, ZrVIII, IX, NbIX, X and MoX, XI

    International Nuclear Information System (INIS)

    Rahimullah, K.; Chaghtai, M.S.Z.; Khatoon, S.

    1976-01-01

    The spectra of Y VII, VIII, Zr VIII, IX, Nb X and Mo X, XI are studied for the first time and the 1971 analysis of Nb IX is improved. By analyses of the transitions 4s 2 4psup(k)-4s 2 4psup(k-1)5s all the levels of the configurations 4p 3 , 4p 2 5s, 4p 2 and 4p5s are established in the spectra concerned. (Auth.)

  17. Adaptabilidad de híbridos triples de maíz y de sus progenitores para la región tropical del sureste de México

    Directory of Open Access Journals (Sweden)

    Mauro Sierra Mac\\u00EDas

    2005-01-01

    Full Text Available Adaptabilidad de híbridos triples de maíz y de susprogenitores para la región tropical del sureste de México.Durante los ciclos primavera-verano de 1998 y 1999 y otoño-invierno de 1997/98 y 1998/99, se condujo una investigaciónen los campos experimentales del INIFAP, Cotaxtla e Isla,Veracruz, Huimanguillo, Tabasco, y Apatzingán, Michoacan,para conocer el rendimiento, adaptabilidad y las característicasagronómicas de híbridos triples de maíz y sus progenitores. Seestablecieron siete experimentos bajo diseños alfalátice condos repeticiones, en parcelas de un surco de 5 m de largo separados a 80 cm, con una densidad de 62.500 plantas por hectárea. Con los híbridos sobresalientes se establecieron parcelasde validación durante los años 1999, 2002 y 2003, en los estados de Veracruz y Tabasco. Hubo híbridos triples estables, quesuperan en rendimiento e igualaron en características agronómicas al testigo comercial H-513. Dentro de los sobresalientesse encuentran: (1 H-513 x CABG3’- 10-1-6-1-1-1, el cual hasido propuesto para su liberación oficial como H-520, (2(CML247 x CML254 x CABG3’-3-4-2-1-3-1, (3 (LRB14 xD539 x CML254, H-513 x LT157, propuesto para su liberación como H-518 y la cruza. En la etapa de validación, loshíbridos H-518 y H-520 registraron rendimientos similares alhíbrido de cruza simple H-513, usado como progenitor hembra en la formación de estos híbridos. Se concluye que la formación de híbridos triples estables y de buen rendimiento, representa una alternativa de aprovechamiento de la heterosiscon las ventajas adicionales en la producción de semillas.

  18. Neoliberalismo e intervencionismo: sus fuentes y razones

    Directory of Open Access Journals (Sweden)

    Salomón Kalmanovitz

    1998-08-01

    Full Text Available A partir de una reseña sobre el papel del intervencionismo estatal en la conducción de la economía y de la pugna con el neoliberalismo, se hace una revisión de los modelos económicos aplicados a lo largo del siglo y se muestran sus rasgos principales, sus problemas y sus paradojas. A partir de alfí, se examina lo sucedido en América Latina, para dar cuenta de las particularidades del caso colombiano, cuyo modelo en esta década muestra una distancia grande del modelo neoliberal, mientras sus problemas lo acercan a los dilemas y sin salidas del intervencionismo, en un contexto que requeriría otras fórmulas para hacer posible la paz. Frente a ello, se examinan las posiciones y propuestas de los economistas, vistas bajo la aguda polarización entre intervencionismo y neoliberalismo, pero en circunstancias críticas que alejan los logros en torno a la modernización, la estabilidad de precios, la sólida fundamentación macroeconómica y la democratización política.

  19. Mitochondrial genome of Taiwan pig (Sus Scrofa)

    African Journals Online (AJOL)

    Jane

    2011-03-28

    Mar 28, 2011 ... The purpose of this study is to investigate the complete nucleotide sequence of the mitochondrial genome of the Taiwan Lanyu pig (Sus scrofa) and its phylogenetic relationships with other pig breeds. Thirty-four forward and reverse primers were designed. Sequencing was performed in both directions.

  20. Acquired factor VIII inhibitor syndrome: A rare cause of hematuria

    Directory of Open Access Journals (Sweden)

    Muthuvel Seral Kannan

    2015-01-01

    Full Text Available A 50-year-old woman presented with gross hematuria for 1 month. Clinical examinations, laboratory investigations, ultrasound and contrast computed tomography were normal, except anemia. Cystoscopy revealed bloody efflux from the right side. Retrograde pyelogram showed filling defect in the renal pelvis and biopsy was inconclusive. Renal angiogram was normal. She developed ecchymosis on the right thigh and arm with elevated activated partial thromboplastin time. The partial thromboplastin time correction study and Bethesda study confirmed the presence of acquired factor VIII inhibitor (acquired hemophilia. With flexible ureterorenoscopy, the mass in the renal pelvis was removed and its histopathology revealed clotted blood. The patient was subsequently managed with steroids and Factor eight inhibitor bypass activity.

  1. Altavoces y Sus Características.

    OpenAIRE

    Cabrera Ortiz, Juan Gabriel

    2015-01-01

    El contenido de aprendizaje aborda la definición de los altavoces desde el campo electroacústico relacionando su principio de funcionamiento mecánico eléctrico y sus características mas importantes como lo son su tipo, respuesta en frecuencia, impedancia, sensibilidad y patrón polar. Contenido realizado por el docente de la Escuela de Ciencias Básicas Tecnología e Ingeniería Ing. Juan G. Cabrera O.

  2. Expression of factor VIII-related antigen in human aqueous drainage channels.

    Science.gov (United States)

    Krohn, J

    1999-02-01

    Previous studies have indicated that there are preformed channels at the inner aspect of the anterior sclera, capable of draining fluid from the suprachoroidal space into scleral veins. The aim of this study was to characterize the cellular lining of these channels, and to compare it with the endothelium of Schlemm's canal, the collector channels and the scleral blood vessels. Histological sections from the angular region of human eyes were prepared by an immunoperoxidase method to evaluate the expression of factor VIII-related antigen in different aqueous drainage channels. The cellular lining of the scleral channels showed a weak immunostaining to factor VIII-related antigen. Factor VIII-related antigen was also detected in the endothelium of the collector channels and Schlemm's canal. The positive immunoreaction to factor VIII-related antigen indicates that the previously described scleral channels, the collector channels and Schlemm's canal are all lined by an endothelium derived from a vascular origin.

  3. Class VIII Medical Materiel Controls in the U.S. European Command

    National Research Council Canada - National Science Library

    1991-01-01

    .... Class VIII medical materiel inventories are maintained as part of the U.S. war reserve stocks to ensure military readiness and to provide needed health care during wartime or contingencies. The U.S...

  4. Bulk moduli and equations of state of ice VII and ice VIII

    Science.gov (United States)

    Klotz, S.; Komatsu, K.; Kagi, H.; Kunc, K.; Sano-Furukawa, A.; Machida, S.; Hattori, T.

    2017-05-01

    The compression behavior of deuterated ice VII and VIII was investigated by high pressure neutron scattering in the pressure range 2-13.7 GPa between 93 and 300 K. We establish equations of state which contain accurate values for the bulk moduli B0, their pressure derivatives B0', as well as the ambient pressure volume V0. These equations of state hold over a large part of the stability domain of ice VII, by comparison with available x-ray data, and to at least ≈13 GPa for ice VIII. They are indistinguishable at low pressures, but beyond ≈7 GPa and at low temperatures ice VIII appears to become stiffer than expected. This might be related to an anomalous phonon hardening observed previously in ice VIII in this P /T range [D. D. Klug et al., Phys. Rev. B 70, 144113 (2004), 10.1103/PhysRevB.70.144113].

  5. Urbanismo y arquitectura en la VIII Región

    Directory of Open Access Journals (Sweden)

    Jaime Garretón Risopatrón

    2015-04-01

    Podremos notar que para una marcha más armoniosa y equilibrada como nación es necesario que crezcan y se desarrollen rápidamente, a lo menos, dos grandes centros urbanos: uno ubicado en el norte y otro situado en el sur. El del sur, sin duda, es Concepción con sus alrededores.

  6. Pengaruh Layanan Informasi Pendidikan Seks terhadap Pengetahuan Siswa Tentang Seks Kelas VIII SMPN

    OpenAIRE

    Citrawati, Neka; Yuline, Yuline; Endang, Busri

    2017-01-01

    This study aims to find out more about how big the influence of sex education information services to students' knowledge about sex in class VIII SMPN 1 Matan Hilir Selatan. The form of this study is the study of relationships. The sample of this research is class VIII students. Data collection techniques used is indirect kominaksi technique in the form of questionnaire amounted to 47 questions on the variables of sex education information services and 47 questions on the student's knowledge ...

  7. Agnostic stacking of intergalactic doublet absorption: measuring the Ne VIII population

    Science.gov (United States)

    Frank, Stephan; Pieri, Matthew M.; Mathur, Smita; Danforth, Charles W.; Shull, J. Michael

    2018-05-01

    We present a blind search for doublet intergalactic metal absorption with a method dubbed `agnostic stacking'. Using a forward-modelling framework, we combine this with direct detections in the literature to measure the overall metal population. We apply this novel approach to the search for Ne VIII absorption in a set of 26 high-quality COS spectra. We probe to an unprecedented low limit of log N>12.3 at 0.47≤z ≤1.34 over a path-length Δz = 7.36. This method selects apparent absorption without requiring knowledge of its source. Stacking this mixed population dilutes doublet features in composite spectra in a deterministic manner, allowing us to measure the proportion corresponding to Ne VIII absorption. We stack potential Ne VIII absorption in two regimes: absorption too weak to be significant in direct line studies (12.3 13.7). We do not detect Ne VIII absorption in either regime. Combining our measurements with direct detections, we find that the Ne VIII population is reproduced with a power-law column density distribution function with slope β = -1.86 ^{+0.18 }_{ -0.26} and normalization log f_{13.7} = -13.99 ^{+0.20 }_{ -0.23}, leading to an incidence rate of strong Ne VIII absorbers dn/dz =1.38 ^{+0.97 }_{ -0.82}. We infer a cosmic mass density for Ne VIII gas with 12.3 < log N < 15.0 of Ω _{{{Ne {VIII}}}} = 2.2 ^{+1.6 }_{ _-1.2} × 10^{-8}, a value significantly lower that than predicted by recent simulations. We translate this density into an estimate of the baryon density Ωb ≈ 1.8 × 10-3, constituting 4 per cent of the total baryonic mass.

  8. Agnostic Stacking of Intergalactic Doublet Absorption: Measuring the Ne VIII Population

    Science.gov (United States)

    Frank, Stephan; Pieri, Matthew M.; Mathur, Smita; Danforth, Charles W.; Michael Shull, J.

    2018-02-01

    We present a blind search for doublet intergalactic metal absorption with a method dubbed `agnostic stacking'. Using a forward-modelling framework we combine this with direct detections in the literature to measure the overall metal population. We apply this novel approach to the search for Ne VIII absorption in a set of 26 high-quality COS spectra. We probe to an unprecedented low limit of log N>12.3 at 0.47≤z ≤1.34 over a pathlength Δz = 7.36. This method selects apparent absorption without requiring knowledge of its source. Stacking this mixed population dilutes doublet features in composite spectra in a deterministic manner, allowing us to measure the proportion corresponding to Ne VIII absorption. We stack potential Ne VIII absorption in two regimes: absorption too weak to be significant in direct line studies (12.3 13.7). We do not detect Ne VIII absorption in either regime. Combining our measurements with direct detections, we find that the Ne VIII population is reproduced with a power law column density distribution function with slope β = -1.86+0.18-0.26 and normalisation log f_{13.7} = -13.99+0.20-0.23, leading to an incidence rate of strong Ne VIII absorbers dn/dz =1.38+0.97-0.82. We infer a cosmic mass density for Ne VIII gas with 12.3 < log N < 15.0 of Ω _{Ne VIII} = 2.2+1.6-1.2 × 10^{-8}, a value significantly lower that than predicted by recent simulations. We translate this density into an estimate of the baryon density Ωb ≈ 1.8 × 10-3, constituting 4% of the total baryonic mass.

  9. A Cranial Trauma was the Cause of Death of Charles VIII of France (1470-1498).

    Science.gov (United States)

    Markatos, Konstantinos; Karamanou, Marianna; Arkoudi, Konstantina; Konstantinidi, Apostolia; Androutsos, Georgios

    2017-09-01

    This article summarizes the reign, life and death, of Charles VIII of France. Also we intend to investigate current views on his cause of death, contradictions and opinions of his biographers. Poisoning, disease, and injury are the possible causes of his death but, according to the literature, cranial trauma was the most probable cause of death of the King Charles VIII of France. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Pharmacokinetics and hemostatic effect of different factor VIII/von Willebrand factor concentrates in von Willebrand's disease type III.

    Science.gov (United States)

    Lethagen, S; Berntorp, E; Nilsson, I M

    1992-12-01

    Four different plasma-derived concentrates composed of coagulation factor VIII (FVIII) and von Willebrand factor (vWF) of varying quality (Hemate-P, Behring; Profilate, Alpha; and F VIII-VHP-vWF, C.R.T.S Lille), or almost purified vWF (Facteur Willebrand, C.R.T.S Lille) and one recombinant F VIII concentrate (Recombinate, Baxter) were given, in doses of 30-60 IU VIII: C/kg or 70-110 IU RCof/kg, to five patients with von Willebrand's disease type III, in order to evaluate the role of the vWF in factor F VIII concentrates. All plasma concentrates except Profilate had a multimeric vWF pattern almost similar to that of normal plasma. Bleeding time (b.t.), VIII: C, vWF:Ag, ristocetin cofactor activity, and multimeric pattern of the plasma-vWF were followed for 72 h. Both Duke b.t. and the multimeric pattern in plasma normalized after infusion of Hemate-P, F VIII-VHP-vWF, and Facteur Willebrand and, to a lesser extent, after Profilate. As expected, in response to Recombinate there was no effect on primary hemostasis, and the half-life of F VIII procoagulant activity (VIII: C) was very short. Normalization of the vWF is important not only for improving the primary hemostasis, but also for maintaining the plasma F VIII concentration on a high level, both by reducing the elimination rate of infused F VIII and via a secondary release of endogenous F VIII. If a prompt hemostatic effect is required, we recommend a concentrate containing both F VIII and all vWF multimers, but for prophylactic treatment, pure vWF may be used.

  11. La Eutonía-Sus Principios

    OpenAIRE

    Rovella, Adriana

    2008-01-01

    El presente trabajo pretende dar cuenta de la Eutonía como práctica corporal dando cuenta de sus objetivos y principios La Eutonía fue creada por Gerda Alexander.El término, del griego, Eu: bueno, óptimo-Tonus: tensión; expresa la idea de una tonicidad armoniosamente equilibrada en adaptación constante al estado o actividad del momento. Es una disciplina basada en la experiencia del propio cuerpo, que conduce a la persona hacia una toma de conciencia de si misma y propone un aprendizaje para ...

  12. TELECENTROS COMUNITARIOS MANIZALES VISTOS POR SUS USUARIOS

    Directory of Open Access Journals (Sweden)

    JUlio César Meza Ramírez

    2015-09-01

    Full Text Available El artículo presenta un ejercicio de evaluación de los Telecentros Comunitarios de la ciudad de Manizales (Caldas, Colombia, con el fin de identificar la percepción que sobre ellos tienen sus usuarios. Para ello se encuestan a 597 usuarios que han cursado alguna de las capacitaciones ofrecidas por Manizales Vive Digital, que reflejan la alta aceptación del programa y su efecto positivo sobre el proceso de inclusión digital en la ciudad.

  13. Estudio sobre el mercado laboral yerbatero, sus protagonistas, y sus luchas

    Directory of Open Access Journals (Sweden)

    María Angélica Jordán

    2013-12-01

    Full Text Available Reseña bibliográfica acerca del libro “Cosechando yerba mate. Estructuras sociales de un mercado agrario en el Nordeste argentino” (2012 de Victor Rau. Dicho estudio analiza el mercado laboral agrario yerbatero, recuperando su historicidad en la región, atendiendo a las estructuras sociales que han condicionando su funcionamiento, como las variables que permitieron la reconfiguración de la estructura del mercado actual, sobretodo a partir de los años ’90. Para ello, se enfoca en los asalariados agrícolas, sus condiciones de venta de fuerza de trabajo, y sus acciones colectiva de protesta.

  14. Factor VIII and fibrinogen recovery in plasma after Theraflex methylene blue-treatment: effect of plasma source and treatment time.

    Science.gov (United States)

    Rapaille, André; Reichenberg, Stefan; Najdovski, Tome; Cellier, Nicolas; de Valensart, Nicolas; Deneys, Véronique

    2014-04-01

    The quality of fresh-frozen plasma is affected by different factors. Factor VIII is sensitive to blood component storage processes and storage as well as pathogen-reduction technologies. The level of fibrinogen in plasma is not affected by the collection processes but it is affected by preparation and pathogen-reduction technologies. The quality of plasma from whole blood and apheresis donations harvested at different times and treated with a pathogen-reduction technique, methylene blue/light, was investigated, considering, in particular, fibrinogen and factor VIII levels and recovery. The mean factor VIII level after methylene blue treatment exceeded 0.5 IU/mL in all series. Factor VIII recovery varied between 78% and 89% in different series. The recovery of factor VIII was dependent on plasma source as opposed to treatment time. The interaction between the two factors was statistically significant. Mean levels of fibrinogen after methylene blue/light treatment exceeded 200 mg/dL in all arms. The level of fibrinogen after treatment correlated strongly with the level before treatment. There was a negative correlation between fibrinogen level before treatment and recovery. Pearson's correlation coefficient between factor VIII recovery and fibrinogen recovery was 0.58. These results show a difference in recovery of factor VIII and fibrinogen correlated with plasma source. The recovery of both factor VIII and fibrinogen was higher in whole blood plasma than in apheresis plasma. Factor VIII and fibrinogen recovery did not appear to be correlated.

  15. Myosin VIII regulates protonemal patterning and developmental timing in the moss Physcomitrella patens.

    Science.gov (United States)

    Wu, Shu-Zon; Ritchie, Julie A; Pan, Ai-Hong; Quatrano, Ralph S; Bezanilla, Magdalena

    2011-09-01

    Plants have two classes of myosins. While recent work has focused on class XI myosins showing that myosin XI is responsible for organelle motility and cytoplasmic streaming, much less is known about the role of myosin VIII in plant growth and development. We have used a combination of RNAi and insertional knockouts to probe myosin VIII function in the moss Physcomitrella patens. We isolated Δmyo8ABCDE plants demonstrating that myosin VIII is not required for plant viability. However, myosin VIII mutants are smaller than wild-type plants in part due to a defect in cell size. Additionally, Δmyo8ABCDE plants produce more side branches and form gametophores much earlier than wild-type plants. In the absence of nutrient media, Δmyo8ABCDE plants exhibit significant protonemal patterning defects, including highly curved protonemal filaments, morphologically defective side branches, as well as an increase in the number of branches. Exogenous auxin partially rescues protonemal defects in Δmyo8ABCDE plants grown in the absence of nutrients. This result, together with defects in protonemal branching, smaller caulonemal cells, and accelerated development in the Δmyo8ABCDE plants, suggests that myosin VIII is involved in hormone homeostasis in P. patens.

  16. The F309S mutation increases factor VIII secretion in human cell line

    Directory of Open Access Journals (Sweden)

    Daianne Maciely Carvalho Fantacini

    2016-06-01

    Full Text Available ABSTRACT OBJECTIVES: The capacity of a human cell line to secrete recombinant factor VIII with a F309S point mutation was investigated, as was the effect of the addition of chemical chaperones (betaine and sodium-4-phenylbutyrate on the secretion of factor VIII. METHODS: This work used a vector with a F309S mutation in the A1 domain to investigate FVIII production in the HEK 293 human cell line. Factor VIII activity was measured by chromogenic assay. Furthermore, the effects of chemical drugs on the culture were evaluated. RESULTS: The addition of the F309S mutation to a previously described FVIII variant increased FVIII secretion by 4.5 fold. Moreover, the addition of betaine or sodium-4-phenylbutyrate increased the secretion rate of FVIIIΔB proteins in HEK 293 cells, but the same effect was not seen for FVIIIΔB-F309S indicating that all the recombinant protein produced had been efficiently secreted. CONCLUSION: Bioengineering factor VIII expressed in human cells may lead to an efficient production of recombinant factor VIII and contribute toward low-cost coagulation factor replacement therapy for hemophilia A. FVIII-F309S produced in human cells can be effective in vivo.

  17. Desenvolvimento de inibidores do fator VIII na hemofilia A Development of factor VIII inhibitors in hemophilia A

    Directory of Open Access Journals (Sweden)

    Daniel G. Chaves

    2009-01-01

    Full Text Available A hemofilia A é uma coagulopatia genética com herança recessiva ligada ao cromossomo X que afeta 1-2 a cada 10 mil indivíduos do sexo masculino nascidos vivos. Estes indivíduos têm baixas concentrações ou ausência do fator VIII (FVIII da coagulação no plasma e apresentam quadros hemorrágicos leves, moderados e graves, dependendo da atividade de FVIII circulante. Estes pacientes necessitam de constante reposição proteica e aproximadamente 30% deles desenvolvem aloanticorpos contra a proteína exógena. A síntese dos anticorpos anti-FVIII é iniciada quando o FVIII exógeno é endocitado por células apresentadoras de antígeno, degradado e apresentado às células T CD4+ na forma de peptídeos ligados a moléculas do complexo maior de histocompatibilidade (MHC de classe II. Alguns fatores de risco (paciente/tratamento podem ser relacionados ao desenvolvimento desta resposta imune. Neste contexto, as mutações no gene do FVIII e polimorfismos em genes envolvidos na resposta imune são candidatos moleculares como determinantes imunogenéticos na predisposição para o desenvolvimento de inibidores. Por não ser completamente entendido e controlado, o desenvolvimento desta resposta imune contra o FVIII constitui o maior problema decorrente do tratamento de indivíduos portadores de hemofilia A e faz-se necessária busca de opções que visem minimizar suas ações deletérias. Algumas alternativas de tratamento têm se mostrado eficazes no tratamento (anti-CD20, plasmaférese, concentrado de complexo protrombínico (PCCs, concentrado de complexo protrombínico ativado (APCCs, fator VII humano ativado, mas a retirada ou neutralização específica dos inibidores de FVIII ainda não foram alcançadas.Hemophilia A, which affects 1-2:10,000 live-born male neonates, is a genetic coagulopathy with recessive inheritance linked to the X chromosome. These individuals have low concentrations or no coagulation factor VIII (FVIII in the plasma

  18. Cuatricentenario: "Alonso Berruguete y sus figuras"

    Directory of Open Access Journals (Sweden)

    Luis Navarro

    1962-01-01

    Full Text Available El Amor y la Muerte, el Extasis y la Nada, gesto español de puro abolengo trágico. He aquí a Don Alonso Berruguete, escultor que nació en la villa de Paredes de Nava, provincia de Palencia, "por los años de 1480" y murió en Toledo el año de 1561. En el Casón del Retiro de Madrid sus silentes "creaturas" celebran con música de Victoria el cuatricentenario del maestro. Sobre el terciopelo verde y escarlata Adoraciones y Calvarios donde se retrata a lo vivo el pensamiento taumaturgo de la España terrible del siglo XVI.

  19. Diagnostic accuracy study of a factor VIII ELISA for detection of factor VIII antibodies in congenital and acquired haemophilia A.

    Science.gov (United States)

    Batty, Paul; Moore, Gary W; Platton, Sean; Maloney, James C; Palmer, Ben; Bowles, Louise; Pasi, K John; Rangarajan, Savita; Hart, Daniel P

    2015-10-01

    Antibody formation to factor VIII (FVIII) remains the greatest clinical and diagnostic challenge to the haemophilia-treating physician. Current guidance for testing for inhibitory FVIII antibodies (inhibitors) recommends the functional Nijmegen-Bethesda assay (NBA). A FVIII ELISA offers a complementary, immunological approach for FVIII antibody testing. It was the aim of this study to retrospectively evaluate the performance of a FVIII ELISA (index) for detection of FVIII antibodies, compared with the NBA (reference). All samples sent for routine FVIII antibody testing at two haemophilia Comprehensive Care Centres, were tested in parallel using the NBA and a solid-phase, indirect FVIII ELISA kit (Immucor). A total of 497 samples from 239 patients (severe haemophilia A=140, non-severe haemophilia A=85, acquired haemophilia A=14) were available for analysis. Sixty-three samples tested positive by the NBA (prevalence 12.7%, 95% confidence interval [CI], 9.9-15.9 %), with a median inhibitor titre of 1.2 BU/ml (range 0.7-978.0). The FVIII ELISA demonstrated a specificity of 94.0% (95%CI, 91.3-96.0), sensitivity of 77.8% (95%CI, 65.5-87.3), negative predictive value of 96.7% (95%CI, 94.5-98.2), positive predictive value 65.3% (95%CI, 53.5-76.0), negative likelihood ratio 0.2 (95%CI, 0.1-0.4), positive likelihood ratio 13.0 (95%CI, 8.7-19.3) and a diagnostic odds ratio of 54.9 (95%CI, 27.0-112.0). Strong positive correlation (r=0.77, pNBA (log adjusted) and FVIII ELISA optical density. In conclusion, FVIII ELISA offers a simple, specific, surveillance method enabling batch testing of non-urgent samples for the presence of FVIII antibodies.

  20. Hemodialysis in a patient with severe hemophilia A and factor VIII inhibitor.

    Science.gov (United States)

    Gopalakrishnan, Natarajan; Usha, Thiruvengadam; Thopalan, Balasubramaniyan; Dhanapriya, Jeyachandran; Dineshkumar, Thanigachalam; Thirumalvalavan, Kaliaperumal; Sakthirajan, Ramanathan

    2016-10-01

    Hemophilia A is a hereditary X-linked recessive disease caused by mutations in the gene encoding factor VIII (FVIII), occurring in 1 out of 10,000 persons. Life expectancy and quality of life have dramatically improved recently in patients with hemophilia. Chronic kidney disease and need for renal replacement therapy in these patients are rare. The development of inhibitors to FVIII is the most serious complication of hemophilia and makes treatment of bleeds very challenging. We describe here a 28-year-old male patient with severe hemophilia A with presence of factor VIII inhibitor, who had end stage renal disease. Central venous access device was inserted along with infusion of factor eight inhibitor bypass activity before and after the procedure. He is currently on thrice weekly hemodialysis and doing well for 6 months without bleeding episodes. To our knowledge, hemophilia A with factor VIII inhibitor managed with hemodialysis has not been reported so far. © 2016 International Society for Hemodialysis.

  1. Lacerations to Zones VIII and IX: It Is Not Just a Tendon Injury

    Directory of Open Access Journals (Sweden)

    Charla R. Fischer

    2011-01-01

    Full Text Available Extensor tendon injuries are widely believed to be straightforward problems that are relatively simple to manage. However, these injuries can be complex and demand a thorough understanding of anatomy to achieve the best functional outcomes. When lacerations occur in the forearm as in Zones VIII and IX injury, the repair of the extensor tendon and muscle, and posterior interosseous nerve (PIN is often challenging. A review of the literature shows little guidance and attention for these injuries. We present four patients with injuries to Zones VIII and IX as well as a review of surgical technique, postoperative rehabilitation, and pearls that may be of benefit to those managing these injuries.

  2. Spectrophotometric determination of hydrogen peroxide with osmium(VIII) and m-carboxyphenylfluorone.

    Science.gov (United States)

    Hoshino, Mitsuru; Kamino, Shinichiro; Doi, Mitsunobu; Takada, Shingo; Mitani, Shota; Yanagihara, Rika; Asano, Mamiko; Yamaguchi, Takako; Fujita, Yoshikazu

    2014-01-03

    Spectrophotometric determination of hydrogen peroxide was accomplished with osmium(VIII) and m-carboxyphenylfluorone (MCPF) in the presence of cetyltrimethylammonium chloride (CTAC). In the determination of hydrogen peroxide based on the fading of the color of osmium(VIII)-MCPF complex, Beer's law was obeyed in the range 20-406 ng mL(-1), with an effective molar absorption coefficient (at 580 nm) of 5.21×10(4) L mol(-1) cm(-1) and a relative standard deviation of 0.33% (n=6). Further, we performed the characterization of MCPF and obtained the crystal structure. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. Structure of D2O ice VIII from in situ powder neutron diffraction

    International Nuclear Information System (INIS)

    Jorgensen, J.D.; Beyerlein, R.A.; Watanabe, N.; Worlton, T.G.

    1984-01-01

    Structural parameters for D 2 O ice VIII have been determined by Rietveld refinement of time-of-flight powder neutron diffraction data collected in situ at 28 kbar and -4 0 C. The D 2 O molecule has a bond length of 0.973 (11) A and a bond angle of 104(2) 0 . O--DxxxO bonds are slightly bent with an angle of 177(1) 0 . Thus, the D 2 O molecules in ice VIII are essentially identical to those observed in other high pressure ice structures for which accurate structural data are available

  4. Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis.

    Science.gov (United States)

    Sinha, S; Kielty, C M; Heagerty, A M; Canfield, A E; Shuttleworth, C A

    2001-10-01

    Type VIII collagen is upregulated after vessel injury, and this collagen has been implicated in both smooth muscle cell migration and angiogenesis. This study examines the temporal and spatial pattern of expression of type VIII collagen in porcine coronary vessels at specific time points after balloon angioplasty. In situ hybridization studies demonstrated that collagen VIII messenger ribonucleic acid (mRNA) was markedly elevated in the neoadventitia at 3 days post-angioplasty. By 14 days, elevated collagen VIII message was seen mainly in the neointima and this expression decreased to background levels by 90 days. The distribution of collagen VIII protein, detected using immunohistochemistry, was similar but the up-regulation lagged behind the mRNA increase by a few days. Pre-treatment of sections with pepsin highlighted variations in the organization and appearance of extracellular collagen VIII containing structures in both injured and normal vessels. New vessel formation was evident in the neoadventitia after 3 days, but there was no colocalization of type VIII collagen immunostaining with that of von Willebrand factor (a marker of endothelial cells) in the neoadventitia. These data show that up-regulation of collagen VIII in the neoadventitia is an important early marker of the coronary arterial response to injury, and is not associated with new vessel formation.

  5. Intracellular retention of a factor VIII protein with an Arg2307-->Gln mutation as a cause of haemophilia A

    NARCIS (Netherlands)

    Voorberg, J.; de Laaf, R. T.; Koster, P. M.; van Mourik, J. A.

    1996-01-01

    Substitution of Arg2307 by Gln in factor VIII has been found to be associated with mild to moderate haemophilia A [Gitschier, Wood, Shuman and Lawn (1986) Science 232, 1415-1416]. We have introduced this particular point mutation into a B-domain-deleted factor VIII cDNA and expressed the modified

  6. Quark matter coupled to domain walls in Bianchi types II, VIII and IX ...

    Indian Academy of Sciences (India)

    In this study of Bianchi types II, VIII and IX Universes, quark matter coupled to domain walls in the context of general relativity are explored. To obtain deterministic solution of the Einstein's field equations, various techniques are adopted. The features of the obtained solution are discussed.

  7. Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

    NARCIS (Netherlands)

    van den Biggelaar, M.; Bouwens, E.A.M.; Kootstra, N.A.; Hebbel, R.P.; Voorberg, J.; Mertens, K.

    2009-01-01

    Background Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this

  8. Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

    NARCIS (Netherlands)

    van den Biggelaar, Maartje; Bouwens, Eveline A. M.; Kootstra, Neeltje A.; Hebbel, Robert P.; Voorberg, Jan; Mertens, Koen

    2009-01-01

    Gene therapy provides an attractive alternative for protein replacement therapy in hemophilia A patients. Recent studies have shown the potential benefit of directing factor (F)VIII gene delivery to cells that also express its natural carrier protein von Willebrand factor (VWF). In this study, we

  9. Safety and Efficacy of BAY 94-9027, a Prolonged-Half-Life Factor VIII

    DEFF Research Database (Denmark)

    Reding, M T; Ng, H J; Poulsen, Lone Hvitfeldt

    2017-01-01

    BACKGROUND: BAY 94-9027 is a B-domain-deleted prolonged-half-life recombinant factor VIII (FVIII) conjugates in a site-specific manner with polyethylene glycol. OBJECTIVE: Assess efficacy and safety of BAY 94-9027 for prophylaxis and treatment of bleeds in patients with severe hemophilia A PATIEN...

  10. Mechanistic aspects of Os(VIII) catalysed oxidation of loop diuretic ...

    Indian Academy of Sciences (India)

    Mechanistic aspects of Os(VIII) catalysed oxidation of loop diuretic drug furosemide by Ag(III) periodate complex in aqueous alkaline medium. SHWETA J MALODEa, NAGARAJ P SHETTIb and SHARANAPPA T NANDIBEWOORa,∗. aPost-Graduate Department of Studies in Chemistry, Karnatak University, Dharwad 580 ...

  11. Aspectos literarios de la obra de don Joan de Castellanos : Capitulo VIII

    Directory of Open Access Journals (Sweden)

    Mario Germán Romero

    1966-03-01

    Full Text Available Capítulo VIII. Los discursos de Jiménez de Quesada. Toda historia de la literatura colombiana comienza con el nombre del licenciado don Gonzalo Jiménez de Quesada. Que era un letrado, no puede ponerse en duda. Los escritos que de él conocemos justifican plenamente el título.

  12. Factor VIII and von Willebrand factor co-delivery by endothelial cells

    NARCIS (Netherlands)

    Bouwens, E.A.M.

    2011-01-01

    A defect in coagulation factor VIII (FVIII) results in the inherited bleeding disorder hemophilia A. Current treatment of hemophilia A is hampered by the need of frequent administration of costly FVIII products. Therefore gene therapy is an attractive alternative for protein replacement to treat

  13. Analysis of mutations in the entire coding sequence of the factor VIII gene

    Energy Technology Data Exchange (ETDEWEB)

    Bidichadani, S.I.; Lanyon, W.G.; Connor, J.M. [Glascow Univ. (United Kingdom)] [and others

    1994-09-01

    Hemophilia A is a common X-linked recessive disorder of bleeding caused by deleterious mutations in the gene for clotting factor VIII. The large size of the factor VIII gene, the high frequency of de novo mutations and its tissue-specific expression complicate the detection of mutations. We have used a combination of RT-PCR of ectopic factor VIII transcripts and genomic DNA-PCRs to amplify the entire essential sequence of the factor VIII gene. This is followed by chemical mismatch cleavage analysis and direct sequencing in order to facilitate a comprehensive search for mutations. We describe the characterization of nine potentially pathogenic mutations, six of which are novel. In each case, a correlation of the genotype with the observed phenotype is presented. In order to evaluate the pathogenicity of the five missense mutations detected, we have analyzed them for evolutionary sequence conservation and for their involvement of sequence motifs catalogued in the PROSITE database of protein sites and patterns.

  14. In vivo recovery and safety of human factor VIII product AAFACT in patients with haemophilia A

    NARCIS (Netherlands)

    Vossebeld, P. J. M.; Tissing, M. H.; van den Berg, H. M.; Leebeek, F. W. G.; de Goede-Bolder, A.; Novakova, I. R. O.; Gerrits, W. B. J.; Peters, M.; Koopman, M. M. W.; Faber, A.; Hiemstra, H.; Grob, P.; Strengers, P. F. W.

    2003-01-01

    AAFACT, a monoclonal purified, solvent/detergent treated human plasma-derived coagulation factor VIII concentrate obtained from plasma of voluntary, non-remunerated blood donors, is manufactured and marketed in the Netherlands by Sanquin Plasma Products since 1995. In a postmarketing surveillance

  15. Exact Bianchi type-VIII and type-IX cosmological models with matter and electromagnetic fields

    Science.gov (United States)

    Lorenz, Dieter

    1980-10-01

    Exact solutions of the Einstein-Maxwell equations of Bianchi types VIII and IX are derived. The solutions represent axisymmetric universes with source-free electromagnetic fields and the matter content of the models is a perfect fluid, with equation of state p=ɛ.

  16. Exact Bianchi type-VIII and type-IX cosmological models with matter and electromagnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Lorenz, D.

    1980-10-15

    Exact solutions of the Einstein-Maxwell equations of Bianchi types VIII and IX are derived. The solutions represent axisymmetric universes with source-free electromagnetic fields and the matter content of the models is a perfect fluid, with equation of state p=epsilon.

  17. Thermal management for LLNL/UC/SSRL bending magnet beamline VIII at Stanford Synchrotron Radiation Laboratory

    International Nuclear Information System (INIS)

    Berglin, E.J.; Younger, F.C.

    1986-05-01

    All the important heat loads on the elements of Beamline VIII are cataloged. The principal elements are identified and their heat loads tabulated for various loading scenarios. The expected heat loads are those from normal operations including the anticipated performance improvements planned for the SPEAR ring and from abnormal operations due to positional perturbations of the electron beam

  18. Absorption signatures of warm-hot gas at low redshift : Ne VIII

    NARCIS (Netherlands)

    Tepper-García, T

    2013-01-01

    At z {lt} 1 a large fraction of the baryons is thought to reside in diffuse gas that has been shock-heated to high temperatures (10$^{5}$-10$^{6}$ K). Absorption by the 770.41, 780.32 å doublet of Ne VIII in quasar spectra represents a unique tool to study this elusive warm-hot phase. We have

  19. Limited promiscuity of HLA-DRB1 presented peptides derived of blood coagulation factor VIII

    NARCIS (Netherlands)

    van Haren, Simon D.; Wroblewska, Aleksandra; Herczenik, Eszter; Kaijen, Paul H.; Ruminska, Aleksandra; ten Brinke, Anja; Meijer, Alexander B.; Voorberg, Jan

    2013-01-01

    The formation of inhibitory antibodies directed against coagulation factor VIII (FVIII) is a severe complication in the treatment of hemophilia A patients. The induction of anti-FVIII antibodies is a CD4(+) T cell-dependent process. Activation of FVIII-specific CD4(+) T cells is dependent on the

  20. Home therapy with continuous infusion of factor VIII after minor surgery or serious haemorrhage.

    Science.gov (United States)

    Varon, D; Schulman, S; Bashari, D; Martinowitz, U

    1996-10-01

    Administration of factor VIII (F VIII) concentrates by continuous infusion is now routinely used at several haemophilia centers but almost exclusively for hospitalized patients. We evaluated various aspects of home therapy with continuous infusion of an immunoaffinity purified F VIII concentrate (Monoclate P®, Armour) in patients who would normally have been treated with high doses in bolus injections or with continuous infusion as in-patients. Twenty haemophilia A patients, eight after minor surgery and 12 for serious haemorrhage, received continuous infusion with undiluted F VIII by a minipump for a mean of 0.9 days in the hospital, followed by 3.3 days at home. Infusion bags were exchanged every 2.5 days. No haemorrhagic complications occurred, and five haemorrhages that had been resistant to treatment with bolus injections responded promptly to the continuous infusion. There were no technical problems and patient compliance and acceptance was good. We find this mode of therapy safe, efficacious and convenient for the patients as well as for the staff.

  1. Lithium ionophore VIII as an extraordinarily effective receptor for the strontium cation: Experimental and theoretical study

    Czech Academy of Sciences Publication Activity Database

    Makrlík, E.; Novák, Vít; Vaňura, P.; Bouř, Petr

    2014-01-01

    Roč. 1061, Mar 5 (2014), s. 110-113 ISSN 0022-2860 Institutional support: RVO:61388963 Keywords : strontium cation * lithium ionophore VIII * complexation * extraction and stability constants * DFT calculations * structures Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.602, year: 2014

  2. Complexation of the cesium cation with lithium ionophore VIII: extraction and DFT study

    Czech Academy of Sciences Publication Activity Database

    Makrlík, E.; Novák, Vít; Vaňura, P.; Bouř, Petr

    2013-01-01

    Roč. 298, č. 3 (2013), s. 2065-2068 ISSN 0236-5731 Institutional support: RVO:61388963 Keywords : cesium cation * lithium ionophore VIII * complexation * extraction and stability constants * water-nitrobenzene system * DFT calculations * structures Subject RIV: CB - Analytical Chemistry , Separation Impact factor: 1.415, year: 2013

  3. La noción de “seguridad humana”: sus virtudes y sus peligros

    OpenAIRE

    Rodríguez Alcázar, Javier

    2012-01-01

    El concepto de seguridad humana ha estado al centro de un amplio debate desde que el PNUD lo adoptara en su ‘‘Informe sobre Desarrollo Humano’’de 1994. Algunos han señalado sus ventajas como alternativa a concepciones más tradicionales de la seguridad, mientras que los críticos del concepto insisten en su ambigüedad y la posibilidad de que sea utilizado para justificar, incluso, acciones violentas en la línea del realismo político. En estas páginas, tras un balance de los pros y contras, se d...

  4. VIII Olimpíada Brasileira de Astronomia e Astronáutica

    Science.gov (United States)

    Garcia Canalle, João Batista; Villas da Rocha, Jaime Fernando; Wuensche de Souza, Carlos Alexandre; Pereira Ortiz, Roberto; Aguilera, Nuricel Villalonga; Padilha, Maria De Fátima Catta Preta; Pessoa Filho, José Bezerra; Soares Rodrigues, Ivette Maria

    2007-07-01

    Neste trabalho apresentamos as motivações pelas quais organizamos, em conjunto, pela primeira vez, a Olimpíada Brasileira de Astronomia incluindo a Astronáutica, em colaboração com a Agência Espacial Brasileira. Esta ampliação contribuiu para atrair ainda mais alunos, professores, escolas e patrocinadores para participarem desta Olimpíada. Em 2005 participaram da VIII Olimpíada Brasileira de Astronomia e Astronáutica (VIII OBA) 187.726 alunos distribuídos por 3.229 escolas, pertencentes a todos os estados brasileiros, incluindo o Distrito Federal. O crescimento em número de alunos participantes foi 52,4% maior do que em 2004. Em abril de 2005 organizamos, em Itapecerica da Serra, SP, um curso para os 50 alunos previamente selecionados e participantes da VII OBA e ao final selecionamos, dentre eles, uma equipe de 5 alunos, os quais representaram o Brasil na X Olimpíada Internacional de Astronomia, na China, em outubro de 2005. Ganhamos, pela primeira vez, uma medalha de ouro naquele evento. Em Agosto de 2005, organizamos a VIII Escola de Agosto para 50 alunos e respectivos professores, em Águas de Lindóia, SP, juntamente com a XXXI reunião anual da Sociedade Astronômica Brasileira (SAB). Em novembro de 2005 realizamos a I Jornada Espacial, em São José dos Campos, com 22 alunos e 22 professores selecionados dentre os participantes que melhores resultados obtiveram nas questões de Astronáutica da VIII OBA. Neste trabalho detalhamos os resultados da VIII OBA bem como as ações subseqüentes.

  5. Monoclonal purified F VIII for continuous infusion: stability, microbiological safety and clinical experience.

    Science.gov (United States)

    Schulman, S; Varon, D; Keller, N; Gitel, S; Martinowitz, U

    1994-09-01

    Replacement therapy for patients with hemophilia A postoperatively or for major hemorrhage, administered as a continuous infusion, is efficient and reduces the requirement for factor VIII (F VIII). The convenience of the method is increased by using a minipump and not diluting the concentrate further after reconstitution. A monoclonally purified F VIII concentrate (Monoclate-P), was evaluated for its stability after reconstitution in different infusion systems, for its microbiological safety as well as clinical safety and efficacy in continuous infusion. The F VIII activity was unaffected by 2 of the 3 infusion systems at room temperature during 15 days, whereas in the third (CADD-1) it decreased below 80% of initial value after 3-7 days. Addition of heparin (1 U/ml) or low molecular weight heparin (1 anti-Xa U/ml), which are used to prevent thrombophlebitis at the site of infusion, did not affect the stability. Nine out of 9 samples taken from the infusion systems after 3 days and again after 7 days were sterile. After inoculation with Staphylococcus aureus or Escherichia coli the bacterial growth in samples of the reconstituted concentrate was not different from that in lidocaine in saline or heparin in saline. F VIII was given in continuous infusion with a minipump (Infu-Med) to 12 patients undergoing major surgery and 8 patients with major hemorrhage for a total of 157 days. A progressive decrease of the clearance was seen during the first 5 days of infusion from 3.0 to 1.7 ml/kg/h. Hemostasis was effectively achieved, and no infectious complications were registered.(ABSTRACT TRUNCATED AT 250 WORDS)

  6. RELATIONSHIP OF INTEREST, LEARNING MOTIVATION AND ATTITUDE WITH RESULTS LEARNING CLASS VIII SMP STATE 13 MAKASSAR

    Directory of Open Access Journals (Sweden)

    Putri Athirah Azis

    2016-12-01

    Full Text Available The study aims at examining (1 the correlation of learning interest towards learning result of grade students, (2 the correlation of learning motivation towards learning result of grade students, (3 the correlation of students attitude towards learning result, (4 the correlationof interest, learning motivation, and attitude collaboratively towards learning result. The study is an ex post facto. The population of the study was grade VIII at SMPN 13 Makassar. Samples were 105 students taken by employing random sampling technique. Data were collected through questionnaire and documentation. Data were analyzed using regression test. The result of study reveal that (1 there is significant correlation (p<0,01 of interest towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,718 and its effectiveness contribution (R2 is 51,5%, (2 there is significant correlation (p<0,01 of motivation towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,775 and its effectiveness contribution (R2 is 60,1%, (3 there is significant correlation (p<0,01 of attitude towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,737 and its effectiveness contribution (R2 is 54,4%, (4 there is significant correlation (p<0,01 of interest, motivation and attitude collaboratively towards learning result of grade VIII students at SMPN 13 Makassar. Co-efficient correlation (r is 0,861 and its effectiveness contribution (R2 is 74,1%,

  7. Los directores aprendiendo de sus maestros

    Directory of Open Access Journals (Sweden)

    Manuel Ortega Muñoz

    2016-07-01

    Full Text Available El presente artículo de investigación está enmarcado dentro de la línea de indagación Aprendizaje para la Gestión y versa sobre los principales aprendizajes que han adquirido los directivos de educación básica del estado de Durango, México, para el mejor ejercicio de su función. Desde un estudio de narrativa, se recopilaron historias de 16 directores de educación primaria estatal pertenecientes a la zona escolar 24 del sector educativo no. 1 de la Secretaría de Educación Pública. El análisis de los datos se llevó a cabo mediante la herramienta de análisis de información cualitativa Atlas ti versión 7.5. Los hallazgos de la investigación muestran que los principales aprendizajes que los directivos de educación básica del estado de Durango, México han adquirido de sus maestros para el mejor ejercicio de su función son dos: a el trabajo en equipo, del cual se desprenden componentes como una eficaz y eficiente organización del trabajo, el trabajar siempre en colaboración y tener la mejor de las actitudes para trabajar; y b el liderazgo compartido, aspecto en que se perciben elementos como el óptimo manejo y resolución de conflictos, el liderazgo y la toma de decisiones en conjunto por parte del colectivo escolar. Abstract This research paper, framed within the line of inquiry Learning Management, deals with the main lessons that have acquired the management of basic education in the state of Durango, Mexico, for the best performance of their duties, from a study of narrative histories of 16 directors of state primary education outside the school zone 24 the education sector 1 of the Ministry of Education. The data analysis was performed using the computer statistical package you Atlas ti version 7.5. The research findings show that there are two main lessons that have acquired the management of basic education in the state of Durango, Mexico from their teachers for the better performance of their function: a teamwork

  8. Laser bendability of SUS430/C11000/SUS430 laminated composite and its constituent layers

    Science.gov (United States)

    Hossein Seyedkashi, S. M.; Gollo, Mohammad Hoseinpour; Biao, Jin; Moon, Young Hoon

    2016-05-01

    Laminated composites are of great interest in different industries while having the advantages of all base metals. In this research, the laser bending of a three-layered SUS430/C11000/SUS430 laminated composite is characterized both experimentally and numerically. This composite can be used in the microelectronics industry since it has the anti-corrosion and strength capability of stainless steel, and the electrical superiority of copper. The specimens are bent using a Ytterbium fiber laser irradiated on a straight path along the sheet width. The effects of bending parameters including the number of passes, scanning velocity, beam diameter, laser power and delay time between passes are examined for a three-layered laminated sheet, and compared with its constituent steel and copper layers. It is found that the thin copper mid-layer strongly affects the rate of bending per pass. Heat distribution and plastic strain along the thickness during the process are characterized by using the finite element method. The Cu mid-layer decreases the bending angle, but also postpones the onset of melting, and thus can be compensated by the application of higher laser powers. It is shown that the bending angle increases with an increase in laser power and delay time, and a decrease in laser velocity and beam diameter.

  9. Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine.

    Science.gov (United States)

    Gilbert, G E; Drinkwater, D

    1993-09-21

    Phosphatidylserine, a negatively charged lipid, is exposed on the platelet membrane following cell stimulation, correlating with the expression of factor VIII receptors. We have explored the importance of the negative electrostatic potential of phosphatidylserine vs chemical moieties of phosphatidylserine for specific membrane binding of factor VIII. Fluorescein-labeled factor VIII bound to membranes containing 15% phosphatidic acid, a negatively charged phospholipid, with low affinity compared to phosphatidylserine-containing membranes. Binding was not specific as it was inhibited by other proteins in plasma. Factor VIII bound to membranes containing 10% phosphatidylserine in spite of a varying net charge provided by 0-15% stearylamine, a positively charged lipid. The soluble phosphatidylserine moiety, O-phospho-L-serine, inhibited factor VIII binding to phosphatidylserine-containing membranes with a Ki of 20 mM, but the stereoisomer, O-phospho-D-serine, was 5-fold less effective. Furthermore, binding of factor VIII to membranes containing synthetic phosphatidyl-D-serine was 5-fold less than binding to membranes containing phosphatidyl-L-serine. Membranes containing synthetic phosphatidyl-L-homoserine, differing from phosphatidylserine by a single methylene, supported high-affinity binding, but it was not specific as factor VIII was displaced by other plasma proteins. O-Phospho-L-serine also inhibited the binding of factor VIII to platelet-derived microparticles with a Ki of 20 mM, and the stereoisomer was 4-fold less effective. These results indicate that membrane binding of factor VIII is mediated by a stereoselective recognition O-phospho-L-serine of phosphatidylserine and that negative electrostatic potential is of lesser importance.

  10. Population pharmacokinetics of recombinant coagulation factor VIII-SingleChain in patients with severe hemophilia A.

    Science.gov (United States)

    Zhang, Y; Roberts, J; Tortorici, M; Veldman, A; St Ledger, K; Feussner, A; Sidhu, J

    2017-06-01

    Essentials rVIII-SingleChain is a unique recombinant factor VIII (FVIII) molecule. A population pharmacokinetic model was based on FVIII activity of severe hemophilia A patients. The model was used to simulate factor VIII activity-time profiles for various dosing scenarios. The model supports prolonged dosing of rVIII-SingleChain with intervals of up to twice per week. Background Single-chain recombinant coagulation factor VIII (rVIII-SingleChain) is a unique recombinant coagulation factor VIII molecule. Objectives To: (i) characterize the population pharmacokinetics (PK) of rVIII-SingleChain in patients with severe hemophilia A; (ii) identify correlates of variability in rVIII-SingleChain PK; and (iii) simulate various dosing scenarios of rVIII-SingleChain. Patients/Methods A population PK model was developed, based on FVIII activity levels of 130 patients with severe hemophilia A (n = 91 for ≥ 12-65 years; n = 39 for  85% and > 93% of patients were predicted to maintain FVIII activity level above 1 IU dL -1 , at all times with three-times-weekly dosing (given on days 0, 2, and 4.5) at the lowest (20 IU kg -1 ) and highest (50 IU kg -1 ) doses, respectively. For twice weekly dosing (days 0 and 3.5) of 50 IU kg -1 rVIII-SingleChain, 62-80% of patients across all ages were predicted to maintain a FVIII activity level above 1 IU dL -1 at day 7. Conclusions The population PK model adequately characterized rVIII-SingleChain PK, and the model can be utilized to simulate FVIII activity-time profiles for various dosing scenarios. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

  11. Proteja a sus seres queridos de las intoxicaciones

    Centers for Disease Control (CDC) Podcasts

    2008-12-10

    Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de una intoxicación, una de las principales causas de lesiones infantiles.  Created: 12/10/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/1/2009.

  12. Proteja a sus seres queridos de las lesiones viales

    Centers for Disease Control (CDC) Podcasts

    2008-12-10

    Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de las lesiones viales, una de las principales causas de lesiones infantiles.  Created: 12/10/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/1/2009.

  13. Proteja a sus seres queridos de un ahogamiento

    Centers for Disease Control (CDC) Podcasts

    2008-12-10

    Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de un ahogamiento, una de las principales causas de lesiones infantiles.  Created: 12/10/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/1/2009.

  14. Proteja a sus seres queridos de las quemaduras

    Centers for Disease Control (CDC) Podcasts

    2008-12-10

    Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres para ayudar a proteger a sus niños de las quemaduras, una de las principales causas de lesiones infantiles.  Created: 12/10/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/1/2009.

  15. Batatins VIII-XI, glycolipid ester-type dimers from Ipomoea batatas.

    Science.gov (United States)

    Rosas-Ramírez, Daniel; Pereda-Miranda, Rogelio

    2015-01-23

    Sweet potato (Ipomoea batatas) is native to the tropics of Central and South America, where many varieties have been consumed for more that 5000 years. In developing countries, this crop is a recognized effective food for fighting malnutrition. Purification of the minor lipophilic glicolipids found in the n-hexane-soluble resin glycosides from the white-skinned variety was performed by preparative-scale recycling HPLC. Application of column overload, peak shaving, heart cutting, and recycling techniques permitted the purification of four new oligosaccharide ester-type dimer derivatives of jalapinolic acid, batatins VIII-XI (1-4). The structural characterization of these complex lipo-oligosaccharides was performed through NMR spectroscopy and MS, indicating that batatins VIII-XI (1-4) possess an oligomeric structure consisting of two pentasaccharide units of the known simonic acid B.

  16. Detection of Intracellular Factor VIII Protein in Peripheral Blood Mononuclear Cells by Flow Cytometry

    Directory of Open Access Journals (Sweden)

    Gouri Shankar Pandey

    2013-01-01

    Full Text Available Flow cytometry is widely used in cancer research for diagnosis, detection of minimal residual disease, as well as immune monitoring and profiling following immunotherapy. Detection of specific host proteins for diagnosis predominantly uses quantitative PCR and western blotting assays. In this study, we optimized a flow cytometry-based detection assay for Factor VIII protein in peripheral blood mononuclear cells (PBMCs. An indirect intracellular staining (ICS method was standardized using monoclonal antibodies to different domains of human Factor VIII protein. The FVIII protein expression level was estimated by calculating the mean and median fluorescence intensities (MFI values for each monoclonal antibody. ICS staining of transiently transfected cell lines supported the method's specificity. Intracellular FVIII protein expression was also detected by the monoclonal antibodies used in the study in PBMCs of five blood donors. In summary, our data suggest that intracellular FVIII detection in PBMCs of hemophilia A patients can be a rapid and reliable method to detect intracellular FVIII levels.

  17. Kinetic Consequences of Chemisorbed Oxygen Atoms during Methane Oxidation on Group VIII Metal Clusters

    OpenAIRE

    Chin, Ya Huei

    2011-01-01

    Molecular insights and the kinetic relevance of reaction elementary steps for methane activation on Group VIII metal and oxide clusters are established based on kinetic, isotopic, and theoretical assessments. These fundamental understandings enable accurate prediction of complex rate dependencies and cluster size effects during methane conversion reactions in catalytic partial oxidation, reforming, and combustion processes.Kinetics of methane reactions with oxygen are described by several reg...

  18. Construction of a mouse model of factor VIII deficiency by gene targeting

    Energy Technology Data Exchange (ETDEWEB)

    Bi, L.; Lawler, A.; Gearhart, J. [Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States)] [and others

    1994-09-01

    To develop a small animal model of hemophilia A for gene therapy experiments, we set out to construct a mouse model for factor VIII deficiency by gene targeting. First, we screened a mouse liver cDNA library using a human FVIII cDNA probe. We cloned a 2.6 Kb partial mouse factor VIII cDNA which extends from 800 base pairs of the 3{prime} end of exon 14 to the 5{prime} end of exon 26. A mouse genomic library made from strain 129 was then screened to obtain genomic fragments covering the exons desired for homologous recombination. Two genomic clones were obtained, and one covering exon 15 through 22 was used for gene targeting. To make gene targeting constructs, a 5.8 Kb genomic DNA fragment covering exons 15 to 19 of the mouse FVIII gene was subcloned, and the neo expression cassette was inserted into exons 16 and 17 separately by different strategies. These two constructs were named MFVIIIC-16 and MFVIIIC-17. The constructs were linearized and transfected into strain 129 mouse ES cells by electroporation. Factor VIII gene-knockout ES cell lines were selected by G-418 and screened by genomic Southern blots. Eight exon 16 targeted cell lines and five exon 17 targeted cell lines were obtained. Three cell lines from each construct were injected into blastocysts and surgically transferred into foster mothers. Multiple chimeric mice with 70-90% hair color derived from the ES-cell genotype were seen with both constructs. Germ line transmission of the ES-cell genotype has been obtained for the MFVIIIC-16 construct, and multiple hemophilia A carrier females have been identified. Factor VIII-deficient males will be conceived soon.

  19. The impact of von Willebrand factor on factor VIII memory immune responses

    OpenAIRE

    Chen, Juan; Schroeder, Jocelyn A.; Luo, Xiaofeng; Shi, Qizhen

    2017-01-01

    Immune tolerance induction (ITI) with aggressive infusion of factor VIII (FVIII) is the current strategy used to eradicate FVIII inhibitors and restore normal FVIII pharmacokinetics in inhibitor patients. Whether the use of FVIII products containing von Willebrand factor (VWF) will affect the efficacy of ITI is still controversial. In this study, we explored the impact of VWF on FVIII memory immune responses in hemophilia A (HA) mice. A T-cell proliferation assay and cytokine profile analysis...

  20. Penggunaan Mind Map Diiringi Musik Klasik Dalam Pembelajaran Matematika Untuk Siswa Kelas VIII SMPN 1 Sawahlunto

    OpenAIRE

    Ramadhona, Rezky

    2016-01-01

    Penelitian ini bertujuan untuk mengetahui apakah motivasi dan hasil belajar belajar matematika siswa kelas VIII SMPN 1 Sawahlunto setelah menggunakan mind map dan musik klasik lebih baik dari sebelum menggunakan mind map dan musik klasik. Jenis penelitian ini adalah penelitian eksperimen dengan menggunakan dua model rancangan yaitu One Group Pretest Posttest Design untuk melihat dampak perlakuan terhadap motivasi belajar dan Randomized Control Group Only Design untuk melihat dampak perlakuan ...

  1. Constraining the Milky Way's Hot Gas Halo with O VII and O VIII Emission Lines

    Science.gov (United States)

    Miller, Matthew J.; Bregman, Joel N.

    2015-02-01

    The Milky Way hosts a hot (≈2 × 106 K), diffuse, gaseous halo based on detections of z = 0 O VII and O VIII absorption lines in quasar spectra and emission lines in blank-sky spectra. Here we improve constraints on the structure of the hot gas halo by fitting a radial model to a much larger sample of O VII and O VIII emission line measurements from XMM-Newton/EPIC-MOS spectra compared to previous studies (≈650 sightlines). We assume a modified β-model for the halo density distribution and a constant-density Local Bubble from which we calculate emission to compare with the observations. We find an acceptable fit to the O VIII emission line observations with χ 2red (dof) = 1.08 (644) for best-fit parameters of no r_c3β = 1.35 +/- 0.24 cm-3 kpc3β and β = 0.50 ± 0.03 for the hot gas halo and negligible Local Bubble contribution. The O VII observations yield an unacceptable χ 2red (dof) = 4.69 (645) for similar best-fit parameters, which is likely due to temperature or density variations in the Local Bubble. The O VIII fitting results imply hot gas masses of M(properties, temperature and entropy gradients in the halo gas, and the gas metallicity distribution. The combination of absorption and emission line analyses implies a sub-solar gas metallicity that decreases with radius, but that also must be >=0.3 Z ⊙ to be consistent with the pulsar dispersion measure toward the Large Magellanic Cloud.

  2. VIII All-Russian symposium on molecular liquid chromatography and capillary electrophoresis. Program. Summary of reports

    International Nuclear Information System (INIS)

    2001-01-01

    Program and summary of reports of the VIII All-Russian symposium on molecular liquid chromatography and capillary electrophoresis are performed. The meeting took place 15-19 October, 2001 in Moscow. Many problems of liquid and ion exchange chromatography, capillary electrophoresis, thin-layer chromatography have been discussed extensively. Reports covering properties of sorbents and devices for chromatography are incorporated in the collection [ru

  3. Structural characterization of the novel aminoglycoside phosphotransferase AphVIII from Streptomyces rimosus with enzymatic activity modulated by phosphorylation

    Energy Technology Data Exchange (ETDEWEB)

    Boyko, Konstantin M., E-mail: kmb@inbi.ras.ru [Bach Institute of Biochemistry, Federal Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt. 33, Bld. 2, 119071, Moscow (Russian Federation); National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation); Gorbacheva, Marina A.; Korzhenevskiy, Dmitry A. [National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation); Alekseeva, Maria G.; Mavletova, Dilara A.; Zakharevich, Natalia V.; Elizarov, Sergey M.; Rudakova, Natalia N.; Danilenko, Valery N. [Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina str. 3, Moscow, 119333 (Russian Federation); Popov, Vladimir O. [Bach Institute of Biochemistry, Federal Research Centre of Biotechnology of the Russian Academy of Sciences, Leninsky Prospekt. 33, Bld. 2, 119071, Moscow (Russian Federation); National Research Center “Kurchatov Institute”, Kurchatov Complex of NBICS-technologies, Akad. Kurchatova sqr., 1, Moscow, 123182 (Russian Federation)

    2016-09-02

    Aminoglycoside phosphotransferases represent a broad class of enzymes that promote bacterial resistance to aminoglycoside antibiotics via the phosphorylation of hydroxyl groups in the latter. Here we report the spatial structure of the 3′-aminoglycoside phosphotransferase of novel VIII class (AphVIII) solved by X-ray diffraction method with a resolution of 2.15 Å. Deep analysis of APHVIII structure and its comparison with known structures of aminoglycoside phosphotransferases of various types reveals that AphVIII has a typical two-domain fold and, however, possesses some unique characteristics that distinguish the enzyme from its known homologues. The most important difference is the presence of the activation loop with unique Ser146 residue. We demonstrate that in the apo-state of the enzyme the activation loop does not interact with other parts of the enzyme and seems to adopt catalytically competent state only after substrate binding. - Highlights: • 3D structure of the novel aminoglycoside phosphotransferase AphVIII was obtained. • AphVIII activation loop is clearly identified in the electron density. • AphVIII has some unique structural features in its substrate C-ring binding pocket.

  4. "Antihemophilic factor is not the only answer for all factor VIII deficiencies." Case report of odontogenic infection in a patient with hemophilia A, complicated by factor VIII inhibitors, and managed by transfusion of antihemophilic factor and factor VIII inhibitor bypass activity.

    Science.gov (United States)

    Sudheesh, K M; Bharani, K S N Siva; Kiran, H Y; Hanagavadi, Suresh

    2016-09-01

    Dental extraction in hemophiliacs with acquired inhibitors is always a risky procedure, which often presents a lot of problems associated with bleeding. A known case of hemophilia A complicated with factor VIII inhibitors and having odontogenic infection was successfully managed by transfusion of factor VIII inhibitor bypass activity (FEIBA) and antihemophilic factor. Past medical history was significant for multiple factor VIII transfusions. Bethesda assay done to identify inhibitors revealed low titer factor VIII inhibitors. Extraction of the involved tooth was done after transfusion of FEIBA with low-dose protocols. Minimal bleeding was noted after extraction which was controlled by local measures. FEIBA was proven to be highly effective, and no side effects of the product were observed.

  5. A close insight to factor VIII inhibitor in the congenital hemophilia A.

    Science.gov (United States)

    Tabriznia-Tabrizi, Shamsoreza; Gholampour, Marzie; Mansouritorghabeh, Hassan

    2016-09-01

    Hemophilia A (HA) has an X-linked pattern of inheritance and is the most common of the hemorrhagic disorders. HA is caused by a decreased or deficiency of the functional clotting factor VIII (FVIII) and effects 1 in 5000-10,000 male births. The common treatment for hemophilia is replacement therapy by plasma-derived or recombinant FVIII. Approximately 20-30% of people with a severe type of HA develop an inhibitor and this phenomenon is the main challenge in the management of these patients. Genetic factors and environmental determinants contribute to inhibitor development. Here, the roles of various genetic and environmental factors such as the type of FVIII concentrate used, the number of exposure days, and peak treatment time will be discussed in detail. It seems this information is helpful for hematologists. A literature review was done in January 2016 on PubMed and Scopus using the following keywords:' h(a)emophilia A & factor VIII inhibitor', 'h(a)emophilia A & factor VIII alloantibody', 'h(a)emophilia A & inhibitor'. There was no time limitation; however, there was an English language limitation placed on the articles selected. Expert commentary: Influential genetic and environmental factors in developing inhibitors have been discussed. Most of the risk factors are related to previously untreated patients with hemophili.

  6. Analise espacial dos aglomerados de nascimentos ocorridos em hospitais SUS e nao SUS do municipio de Sao Paulo, Brasil

    Directory of Open Access Journals (Sweden)

    Patricia Carla dos Santos

    2014-01-01

    Full Text Available O objetivo deste estudo é avaliar a distribuição espacial de nascidos vivos (NV do município de São Paulo (MSP, verificar se há dependência espacial, identificar possíveis diferenças no perfil dos nascimentos e avaliar as distâncias percorridas entre os domicílios e os hospitais do parto. Foram estudados os NV ocorridos em hospitais de alta complexidade, quatro SUS e quatro da rede não SUS no MSP em 2008. Foram georreferenciados 46.190 NV: 48,8% em hospitais SUS e 51,2% não SUS, estes representaram 27,9% do total de NV do MSP. Os NV de hospitais SUS formaram dois aglomerados com elevada proporção de domicílios com renda de 1/2 a 2SM, concentração de favelas e altas taxas de natalidade. Os NV de hospitais não SUS formaram um aglomerado na região central do MSP, onde há elevada proporção de domicílios com renda > 10 SM e baixa natalidade. Foram encontradas diferenças estaticamente significantes das características maternas, da gestação e do parto entre os NV de hospitais SUS e não SUS e da frequência de gemelaridade. Não houve diferença na prevalência de baixo peso e pré-termo. Os resultados mostraram existir diferenciais no perfil dos aglomerados de NV, que refletem as desigualdades das condições de vida do MSP.

  7. La violencia de hijos adolescentes contra sus progenitores La violencia de hijos adolescentes contra sus progenitores

    Directory of Open Access Journals (Sweden)

    Concepción Aroca Montolío

    2013-10-01

    Full Text Available According to Prosecutor’s Office of the Minor, the accusation interposed by mothers and/or fathers victims by theirs children, along 2007 were 2603, in 2008 amounted 4.211, in 2009 there were 5.209 and in 2010 there were 8.000 accusations. Suede this worrying increase, the principal aim of our article is to check the scientific international and national documentation, from 1957 until the year 2010 that analyses the phenomenon of the adolescent violence against parents, to achieve an approximation to its keys that there allows us the comprehension and analysis of this serious familiar problem. For it we will analyse: (a the importance of this crime by means of criminological mediators: prevalence and incidence; (b the age and sex variables’ aggressors to be able to establish a basic profile about theirs and, (c the violence types that the teenagers wield to damage, prejudice and suffering against their progenitors, with the aim to obtain what they want. The information obtained in this research review and qualitative analysis, change in base to the methodology used and the type of sample under study to obtain conclusions. Even though, we wantto do research into needs to investigate this type of familiar violence, and from there, to do researches with rigorous scientific methodologies, unifying criteria and variables to be investigating, to be able to anticipate in this increasing problem that the parents have. Según la Fiscalía del Menor en el año 2007, las denuncias interpuestas por madres y/o padres, víctimas de malos tratos por sus hijos e hijas menores de edad, fueron 2.683. En 2008 ascendieron a 4.211, en 2009 se presentaron 5.209 y en el año 2010 se registraron 8.000 denuncias. Ante éste preocupante incremento, el objetivo principal de nuestro artículo es revisar la documentación científica que analiza la violencia filio-parental,  desde 1957 hasta el año 2011, para lograr una aproximación a sus claves que nos permita la

  8. PENINGKATAN PEMBELAJARAN MENULIS PUISI BEBAS MELALUI MEDIA LAGU MEDLEY SISWA KELAS VIII SMP SINTANG

    Directory of Open Access Journals (Sweden)

    Rohanawati Silalahi

    2015-05-01

    Full Text Available Penelitian ini bertujuan untuk meningkatkan pembelajaran menulis puisi bebas melalui media lagu medley siswa kelas VIII B SMP Sintang. Subjek penelitian adalah siswa kelas VIII B SMP Sintang. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK. Prosedur pelaksanaan dan implementasi penelitian dilaksanakan dalam dua siklus. Teknik pengumpulan data berupa obsevasi, wawancara, catatan lapangan, angket, evaluasi dan dokumentasi. Instrumen pengumpulan data meliputi lembar wawancara, lembar catatan lapangan, lembar angket, lembar tes hasil belajar dan lembar portofolio serta dokumentasi foto kegiatan. Teknik analisis data yang digunakan adalah analisis data kuantitatif dan kualitatif. Hasil penelitian ini menunjukkan bahwa penggunaan media lagu medley dapat meningkatkan pembelajaran menulis puisi bebas. Peningkatan hasil atau produk dapat dilihat dari perbandingan skor rata-rata keterampilan menulis puisi bebas siswa pada setiap siklus. Nilai rata-rata siswa pada tahap pratindakan adalah 55,23, pada saat siklus I meningkat menjadi 71,18, dan pada siklus II meningkat menjadi 73,4. ___________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________ DEVELOPING THE TEACHING OF FREE VERSE WRITING THROUGH MEDLEY SONG MEDIA TO GRADE VIII STUDENTS OF SMP SINTANG   Abstract This study aims to improve the teaching of free verse writing through medley song media to Grade VIII B students of SMP Sintang. The research subjects were Grade VIII B students of SMP Sintang,. This was a classroom action research (CAR. The research procedure and implementation were conducted in two cycles. The data were collected through observations, field notes, questionnaires, evaluations, and documentations. The data collecting instruments included interview sheets, field note sheets

  9. Inmigrantes andinos en Madrid: Sus danzas y sus músicas tradicionales

    Directory of Open Access Journals (Sweden)

    Lourdes Morales

    2007-01-01

    Full Text Available In our urban context we get in touch with people that have been forced to leave their countries under different circumstances in order to live in Spain. This article analyses their wish to maintain a group identity and how this identity is materialized by some individuals through traditional dance and music. The study is intended as a framework for subsequent educational investigations that relate that cultural reality with the situation in secondary schools where children of Latin American immigrants study.Nuestro entorno ciudadano inmediato nos pone en contacto diario con personas que por diferentes razones se han visto obligadas a dejar sus países de origen para instalarse en España. Este artículo analiza el deseo que surge en ellas de mantener una identidad de grupo, y cómo ésta se concreta en ciertos individuos mediante manifestaciones de danza y música popular tradicional. El estudio pretende servir de marco para ulteriores investigaciones educativas que vinculen esa realidad cultural con la situación de institutos de enseñanza secundaria en los que estudian hijos de inmigrantes latinoamericanos.

  10. Dry-heat treatment process for enhancing viral safety of an antihemophilic factor VIII concentrate prepared from human plasma.

    Science.gov (United States)

    Kim, In Seop; Choi, Yong Woon; Kang, Yong; Sung, Hark Mo; Shin, Jeong Sup

    2008-05-01

    Viral safety is a prerequisite for manufacturing clinical antihemophilic factor VIII concentrates from human plasma. With particular regard to the hepatitis A virus (HAV), a terminal dry-heat treatment (100 degrees for 30 min) process, following lyophilization, was developed to improve the virus safety of a solvent/detergent-treated antihemophilic factor VIII concentrate. The loss of factor VIII activity during dry-heat treatment was of about 5%. No substantial changes were observed in the physical and biochemical characteristics of the dry-heat-treated factor VIII compared with those of the factor VIII before dry-heat treatment. The dry-heat-treated factor VIII was stable for up to 24 months at 4oC. The dry-heat treatment after lyophilization was an effective process for inactivating viruses. The HAV, murine encephalomyocarditis virus (EMCV), and human immunodeficiency virus (HIV) were completely inactivated to below detectable levels within 10 min of the dry-heat treatment. Bovine herpes virus (BHV) and bovine viral diarrhea virus (BVDV) were potentially sensitive to the treatment. However porcine parvovirus (PPV) was slightly resistant to the treatment. The log reduction factors achieved during lyophilization and dry-heat treatment were > or =5.55 for HAV, > or =5.87 for EMCV, > or =5.15 for HIV, 6.13 for BHV, 4.46 for BVDV, and 1.90 for PPV. These results indicate that dry-heat treatment improves the virus safety of factor VIII concentrates, without destroying the activity. Moreover, the treatment represents an effective measure for the inactivation of non-lipid-enveloped viruses, in particular HAV, which is resistant to solvent/detergent treatment.

  11. A experiência da pesquisa EnsinaSUS The experience of EnsinaSUS research

    Directory of Open Access Journals (Sweden)

    Lilian Koifman

    2007-06-01

    Full Text Available Este artigo descreve a trajetória do projeto EnsinaSUS, da pesquisa desenvolvida em seu interior e das múltiplas dimensões e implicações na direção do conhecimento das experiências que têm sido realizadas nos cursos da área de saúde em relação aos processos de mudança que estão em desenvolvimento. Pretendemos compartilhar a experiência de integração de pesquisadores, de diferentes origens institucionais e profissionais, na construção de um projeto comum, alimentado da vivência desses atores. Essa experiência almejou inovar e construir uma nova gramática para discussão e compreensão dos processos pedagógicos e sua interface com a saúde e o trabalho, na produção de um cuidado que se faça distinto na concepção da assistência à saúde, produzindo cuidado usuário-centrado, numa perspectiva dialógica e ético-política. Entendemos que as práticas de ensino e extensão funcionam como dispositivos abertos de um 'fazer-pensar-saber' em integralidade, forjando novas concepções, sentidos e significados da saúde, da vida, do conhecimento e da educação. Pautamo-nos na idéia de que as explicações da práxis pedagógica podem ser entendidas como possibilidade da construção histórica da cidadania. Encontramos alguns mecanismos de legitimação e canais de articulação, intercâmbio e solidariedade como resposta de interação de diversidades. A equipe representou a composição de redes de representação em espaços culturais e políticos plurais.This article describes the EnsinaSUS Project, the research developed within the project, and the various dimensions and implications that will lead to understanding the experiences that have been taking place in courses in the field of health care as regards their processes of change. Our aim is to share the experience of integrating researchers, coming from different institutional and professional backgrounds, in order to build a common project, based on their

  12. ElecSus: Extension to arbitrary geometry magneto-optics

    Science.gov (United States)

    Keaveney, James; Adams, Charles S.; Hughes, Ifan G.

    2018-03-01

    We present a major update to ElecSus, a computer program and underlying model to calculate the electric susceptibility of an alkali-metal atomic vapour. Knowledge of the electric susceptibility of a medium is essential to predict its absorptive and dispersive properties. In this version we implement several changes which significantly extend the range of applications of ElecSus, the most important of which is support for non-axial magnetic fields (i.e. fields which are not aligned with the light propagation axis). Supporting this change requires a much more general approach to light propagation in the system, which we have now implemented. We exemplify many of these new applications by comparing ElecSus to experimental data. In addition, we have developed a graphical user interface front-end which makes the program much more accessible, and have improved on several other minor areas of the program structure.

  13. Rosario Castellanos, feminista a partir de sus propias palabras

    Directory of Open Access Journals (Sweden)

    Marta Lamas

    2017-06-01

    Full Text Available A partir del análisis de sus escritos periodísticos, se recupera a Rosario Castellanos como una pionera intelectual del feminismo mexicano. Se defiende la idea de que en sus artículos periodísticos se plasma con fuerza y lucidez un pensamiento feminista moderno, que gira en torno a los efectos del mandato cultural de la feminidad, aportando a la crítica de la situación de las mujeres mexicanas. Castellanos rechaza el victimismo, reivindica la necesidad de terminar con la autocomplacencia femenina y propone que las mujeres se responsabilicen de sus vidas, madurando y puliendo ideas que hoy en día tienen vigencia y radicalidad notables.

  14. Strategies for sustainable households. The SusHouse project

    International Nuclear Information System (INIS)

    Vergragt, Ph.J.; Knot, J.M.C.

    2001-01-01

    The international SusHouse project has developed a strategy design approach that can contribute to major (factor 20) efficiency improvements in household activities. Stakeholder workshops have been held to develop scenarios for a sustainable future (2050). These scenarios were evaluated on their economic consequences, environmental impacts and consumer acceptance. the results were then used as the input for a second round of stakeholder workshops, which aimed at developing short-term strategies and implementation plans. This Research Note reviews the SusHouse approach and its results. It ends with suggestions for further steps to be taken. A SusHouse CD-ROM is available, containing all final project reports as well as a scenario presentation in the form of images and short texts. 22 refs

  15. Desempenho e características de carcaça de cordeiros das raças Texel, Suffolk e cruza Texel x Suffolk Performance and characteristics of the carcass of lambs the breed Texel, Suffolk and cross Texel x Suffolk

    Directory of Open Access Journals (Sweden)

    Sérgio Carvalho

    2005-10-01

    Full Text Available Este experimento objetivou comparar o desempenho e as características de carcaça de 14 cordeiros, sendo quatro da raça Texel, cinco da raça Suffolk e cinco cruza Texel x Suffolk. Os cordeiros foram desmamados aos 64 dias de idade em média, e terminados em regime de confinamento total, até o abate com idade média de 128 dias. Do nascimento ao desmame, as ovelhas (mães dos cordeiros foram mantidas em pastagem nativa e receberam uma suplementação concentrada na proporção de 1% de peso vivo, tendo também os cordeiros acesso a uma suplementação concentrada na forma de creep-feeding na proporção de 1,5% do peso vivo. O alimento concentrado utilizado na suplementação das ovelhas e dos cordeiros continha 21% de proteína bruta (PB, 70% de nutrientes digestíveis totais (NDT, 2% de cálcio (Ca e 0,4% de fósforo (P. Após o desmame, os cordeiros passaram a receber uma dieta composta por feno de Tifton-85 (Cynodon dactylon + concentrado, na proporção 40:60 na Matéria Seca (MS, a qual continha 15,1% de PB, 60,8% de NDT, 1,4% de Ca e 0,3% de P. O peso ao abate foi inferior (PThe objective of this work was to compare the performance and carcass characteristics of 14 lambs, being four of the Texel, five of the Suffolk and five cross Texel x Suffolk breeds. The lambs were weaned at 64 days of age in average, and finished in feedlot, until slaughtering with average age of 128 days. From birth to weaning, dams were maintained in native pasture and received a concentrated supplementation at a 1% ratio of live weight and lambs had access to a concentrated supplementation in the form of creep-feeding at a 1.5% ratio of the live weight. The concentrated food used in the supplementation of the sheep and the lambs contained 21% of crude protein (CP, 70% of total digestible nutrients (TDN, 2% of calcium (Ca and 0.4% of phosphorus (P. After weaning, lambs started to receive a composed diet of hay made of Tifton-85 (Cynodon dactylon + concentrate

  16. Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

    Energy Technology Data Exchange (ETDEWEB)

    Ngo, J.C.; Huang, M.; Roth, D.A.; Furie, B.C.; Furie, B. (Wyeth); (MBL)

    2008-06-03

    Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca{sup 2+} and two Cu{sup 2+} ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

  17. Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex

    Energy Technology Data Exchange (ETDEWEB)

    Chi Ki Ngo,J.; Huang, M.; Roth, D.; Furie, B.; Furie, B.

    2008-01-01

    Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca(2+) and two Cu(2+) ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

  18. Analysis of inversions in the factor VIII gene in Spanish hemophilia A patients and families

    Energy Technology Data Exchange (ETDEWEB)

    Domenech, M.; Tizzano, E.; Baiget, M. [Hospital de Sant Pau, Barcelona (Spain); Altisent, C. [Hospital Vall d`Hebron, Barcelona (Spain)

    1994-09-01

    Intron 22 is the largest intron of the factor VIII gene and contains a CpG island from which two additional transcripts originate. One of these transcripts corresponds to the F8A gene which have telomeric extragenic copies in the X chromosome. An inversion involving homologous recombination between the intragenic and the distal or proximal copies of the F8A gene has been recently described as a common cause of severe hemophilia A (HA). We analyzed intron 22 rearrangements in 195 HA patients (123 familial and 72 sporadic cases). According to factor VIII levels, our sample was classified as severe in 114 cases, moderate in 29 cases and mild in 52 cases. An intron 22 (F8A) probe was hybridized to Southern blots of BcII digested DNA obtained from peripheral blood. A clear pattern of altered bands identifies distal or proximal inversions. We detected an abnormal pattern identifying an inversion in 49 (25%) of the analyzed cases. 43% of severe HA patients (49 cases) showed an inversion. As expected, no inversion was found in the moderate and mild group of patients. We found a high proportion (78%) of the distal rearrangement. From 49 identified inversions, 33 were found in familial cases (27%), while the remaining 15 were detected in sporadic patients (22%) in support that this mutational event occurs with a similar frequency in familial or sporadic cases. In addition, we detected a significant tendency of distal inversion to occur more frequently in familial cases than in sporadic cases. Inhibitor development to factor VIII was documented in approximately 1/3 of the patients with inversion. The identification of such a frequent molecular event in severe hemophilia A patients has been applied in our families to carrier and prenatal diagnosis, to determine the origin of the mutation in the sporadic cases and to detect the presence of germinal mosaicism.

  19. Comercio Internacional mediterráneo en el siglo VIII a.C.

    Directory of Open Access Journals (Sweden)

    Paloma Cabrera Bonet

    2018-01-01

    Full Text Available The VIII century B.C. saw, for the first time after the breakdown of the system in the Late Bronze Age, the revival of a true intemational trade at a growing scale, especíally protagonized by Phoenicians and Greeks. In this article we analyze sorne aspects of this phenomenon, from the Aegean to the Far West, which made possíble, through a vaste network of trading routes, a large multinational ínteractíon. We understand the international trade as a key factor in the proccess of economic, social and political changes of the Mediterranean areas submerged in this complex "world-system".

  20. Estudo da articulação temporomandibular em camundongos deficientes de fator VIII

    OpenAIRE

    Patricia do Socorro Queiroz Feio

    2010-01-01

    Resumo: A hemofilia é uma doença hemorrágica hereditária ligada ao cromossomo X, decorrente da ausência ou da baixa quantidade no plasma dos fatores de coagulação Fator VIII (hemofilia A) ou do Fator IX (hemofilia B). Clinicamente, a hemofilia se caracteriza por episódios recorrentes de sangramentos profundos, que podem ocorrer espontaneamente ou em decorrência de traumatismos. O sistema músculo-esquelético é freqüentemente afetado pelos eventos hemorrágicos nos pacientes portadores de hemofi...

  1. Underground Test Area Subproject Phase I Data Analysis Task. Volume VIII - Risk Assessment Documentation Package

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-12-01

    Volume VIII of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the risk assessment documentation. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

  2. IMPLIKASI YURIDIS PUTUSAN MK NOMOR 46/PUU- VIII/ 2010 TERHADAP AKTA KELAHIRAN ANAK LUAR KAWIN

    Directory of Open Access Journals (Sweden)

    Djumikasih Djumikasih

    2014-08-01

    Full Text Available Abstract This paper aims to identify and analyze what the juridical implications of the publication of the decision of the Constitutional Court No. 46/PUU-VIII / 2010 on Child Outside Marriage Deed which has been published by the Department of Population and Civil Registration prior to the establishment of the Constitutional Court's decision . The method used in this study is a normative juridical approach legislation. From the discussion, it can be concluded that the Constitutional Court 46/PUU-VIII/2010 Number of Tests on Article 43 paragraph ( 1 Marriage Act ( Act No. 1 of 1974 when viewed from the angle of legal certainty it will lead to legal certainty . But the decision will not have any juridical implications of the child's birth certificate that has been published outside of marriage and illegitimate child who was born before the date of February 17, 2012, as if enacted would be contrary to the principle of legality is interpreted Article 47 of the Law on the Constitutional Court and Article 28 ( i of the 1945 Constitution . Likewise, if the terms of the fairness and usefulness , especially for justice seekers / applicant , the timing of this decision is not fair and not useful , because although the Court granted the petition but the Constitutional Court can not be applied to her .   Key words: yuridical implication, birth certificate, children who are born outside of marriage   Abstrak   Tulisan ini bertujuan untuk mengetahui dan menganalisis apa implikasi yuridis dari terbitnya putusan MK Nomor 46/PUU-VIII/ 2010 terhadap Akta Anak Luar Kawin yang sudah diterbitkan oleh Dinas Kependudukan dan Catatan Sipil sebelum lahirnya putusan MK tersebut. Metode yang digunakan dalam penelitian ini adalah yuridis normative dengan pendekatan perundang-undangan. Dari pembahasan dapat disimpulkan bahwa Putusan MK Nomer 46/PUU-VIII/2010 tentang Pengujian terhadap Pasal 43 ayat (1 UU Perkawinan (UU NO 1 Tahun 1974 jika dilihat dari sudut kepastian

  3. Optimisation of the Factor VIII yield in mammalian cell cultures by reducing the membrane bound fraction

    DEFF Research Database (Denmark)

    Kolind, Mille Petersen; Nørby, Peder Lisby; Berchtold, Martin Werner

    2011-01-01

    In vivo, clotting Factor VIII (FVIII) circulates in plasma bound to von Willebrand factor (vWF), and the vWF:FVIII complex prevents binding of FVIII to phosphatidylserine (PS). Activation of FVIII by thrombin releases FVIII from vWF, and subsequently FVIII binds to PS exposed on activated platelets...... or ortho-phospho-L-serine (OPLS) demonstrated that annexin V and OPLS were able to reduce the membrane bound fraction of rFVIII by 70% and 30%, respectively. Finally, adding OPLS to CHO cells stably expressing FVIII increased the yield by 50%. Using this new knowledge, the recovery of rFVIII could...

  4. IDENTIFICATION OF RNA STRUCTURES MODULATING THE EXPRESSION OF THE mRNA BIOGENESIS FACTOR SUS1

    OpenAIRE

    ABUQATTAM, ALI NA

    2017-01-01

    Sus1 is a conserved protein involved in chromatin remodeling and mRNA biogenesis. The SUS1 gene of Saccharomyces cerevisiae is unusual, as it contains two introns and is alternatively spliced, retaining one or both introns in response to changes in environmental conditions. SUS1 splicing may allow the cell to control Sus1 expression, but the mechanisms that regulate this process remain unknown. In this thesis project, we have investigated whether the structure adopted by SUS1 RNA sequences co...

  5. KEEFEKTIFAN MODEL TGT DENGAN PENDEKATAN SCIENTIFIC BERBANTUAN CD PEMBELAJARAN TERHADAP KEMAMPUAN PEMECAHAN MASALAH SISWA SMP KELAS VIII PADA MATERI LINGKARAN

    Directory of Open Access Journals (Sweden)

    Singgih Baswendro

    2015-11-01

    Full Text Available Artikel ini dibuat berdasarkan penelitian skripsi yang telah dilaksanakan. Tujuan penelitian ini adalah (1 untuk mengetahui hasil kemampuan pemecahan masalah siswa kelas VIII pada materi lingkaran dengan menggunakan model TGT mencapai KKM, dan (2 untuk mengetahui rata-rata kemampuan pemecahan masalah siswa dengan model TGT lebih tinggi daripada dengan model ekspositori. Penelitian ini dilaksanakan di SMP Negeri 3 Ungaran dengan populasi siswa kelas VIII tahun ajaran 2014/2015. Pengambilan kelas sampel menggunakan teknik cluster random sampling. Untuk mengetahui hasil penelitian ini, data hasil akhir diuji dengan uji proporsi dan uji perbedaan rata-rata. Hasil penelitan ini menunjukkan bahwa (1 hasil kemampuan pemecahan masalah siswa kelas VIII pada materi lingkaran dengan menggunakan model TGT mencapai KKM, dan (2 rata-rata kemampuan pemecahan masalah siswa dengan model TGT lebih tinggi daripada dengan model ekspositori. Dengan ini maka model TGT dengan pendekatan scientific berbantuan CD pembelajaran efektif terhadap kemampuan pemecahan masalah siswa.

  6. Evolution of microstructure and mechanical properties of SUS430/C11000/SUS430 composites during the laser-forming process

    Science.gov (United States)

    Abazari, Hamed Delfan; Seyedkashi, Seyed Mohammad Hossein; Gollo, Mohammad Hoseinpour; Moon, Young Hoon

    2017-09-01

    Multilayered sheet metals have been widely used to achieve a wide range of favorable mechanical, physical, thermal and electrical properties. Laser beam irradiation over these materials creates extreme temperature changes that can lead to changes in the microstructural properties. Microstructure plays a very crucial role in determining the mechanical property of the irradiated region, thus determining the optimum laser processing conditions. In this study, metallographic studies, as well as tensile, fatigue and hardness tests, are undertaken on SUS430/C11000/SUS430 laminated composites that have been exposed to laser irradiation with different number of passes. This composite can be used in the microelectronics industry since it has the anti-corrosion and strength capability of stainless steel, and the electrical superiority of copper. Ytterbium fiber laser is used in such a way that the governing mechanism of the process is the temperature gradient mechanism. Evolution of the microstructure is revealed by metallography, and the fracture levels of tension and fatigue test specimens are further evaluated by SEM. This study illustrates the significant effects of successive laser irradiation on the evolution of microstructure and mechanical properties, which lead to some suggestions for improving the properties of laser-formed SUS430/C11000/SUS430 composites.

  7. The head that wears the crown: Henry VIII and traumatic brain injury.

    Science.gov (United States)

    Ikram, Muhammad Qaiser; Sajjad, Fazle Hakim; Salardini, Arash

    2016-06-01

    Henry VIII of England is one of the most controversial figures in European history. He was born on 28 June 1491 as the second son of Henry VII and Elizabeth of York and became the heir to the English throne after his elder brother died prematurely. A contradictory picture of Henry's character emerges from history: the young Henry was a vigorous, generous and intelligent king who saw early military and naval successes. In contrast, in his later years he became cruel, petty and tyrannical. His political paranoia and military misjudgements are in direct contrast to his earlier successes and promise. Several hypotheses have been put forward regarding his transformation from a renaissance king to a later medieval tyrant, including endocrinopathies, psychiatric illnesses and traumatic brain injury. In this paper we examine the historical evidence linking the change in Henry's personality and health problems to traumatic brain injury. To our knowledge this is the first systematic neurological study of traumatic brain injury in Henry VIII. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. KEANEKARAGAMAN HYMENOPTERA PARASITOID PADA PERKEBUNAN KELAPA SAWIT PTPN VIII CINDALI, BOGOR

    Directory of Open Access Journals (Sweden)

    Ichsan Luqmana Indra Putra

    2016-09-01

    Full Text Available Diversity of parasitic Hymenoptera in PTPN VIII oil palm plantation Cindali, Bogor. One group of important natural enemies in oil palm plantation is parasitic Hymenoptera. The purpose of this research is to know the diversity and fluctuation of parasitic Hymenoptera PTPN VIII Cindali oil palm plantation. This research was conducted in 6 blocks of oil palm in September 2014 – June 2015. There were 5 plots in every observation blocks 39.2 x 39.2 m in size, and used direct and indirect method. Direct method done by 5 plants in every plots was taken randomized to observed and taken the herbivore insects to reared until the parasitic Hymenoptera came out. Observation of cover crops conducted by 3 subplots determined diagonally in every plots 9.8 x 9.8 m in size and herbivore insects was observed and collected. Indirect methods used sweep net and yellow pan trap. The result of this research, 26 parasitic Hymenoptera families was found, with the Braconidae was the most morphospecies found and the most individual amount was Scelionidae. The abundance of parasitoid in every month fluctuated.

  9. Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A

    Science.gov (United States)

    Sherman, Alexandra; Biswas, Moanaro; Herzog, Roland W.

    2017-01-01

    Hemophilia A (coagulation factor VIII deficiency) is a debilitating genetic disorder that is primarily treated with intravenous replacement therapy. Despite a variety of factor VIII protein formulations available, the risk of developing anti-dug antibodies (“inhibitors”) remains. Overall, 20–30% of patients with severe disease develop inhibitors. Current clinical immune tolerance induction protocols to eliminate inhibitors are not effective in all patients, and there are no prophylactic protocols to prevent the immune response. New experimental therapies, such as gene and cell therapies, show promising results in pre-clinical studies in animal models of hemophilia. Examples include hepatic gene transfer with viral vectors, genetically engineered regulatory T cells (Treg), in vivo Treg induction using immune modulatory drugs, and maternal antigen transfer. Furthermore, an oral tolerance protocol is being developed based on transgenic lettuce plants, which suppressed inhibitor formation in hemophilic mice and dogs. Hopefully, some of these innovative approaches will reduce the risk of and/or more effectively eliminate inhibitor formation in future treatment of hemophilia A. PMID:29225598

  10. PROSES BERPIKIR SISWA KELAS VIII DALAM MENYELESAIKAN SOAL MATEMATIKA TIMSS MATERI BESAR SUDUT DALAM BENTUK GEOMETRIS

    Directory of Open Access Journals (Sweden)

    Nurul Hidayati Arifani

    2017-07-01

    Full Text Available This study aims to describe the students' thinking process in solving TIMSS math problem on measurement of angle in geometric shapes based on Polya’s problem solving step associated with Swartz’s thinking process theory. The subject of the research was a grade VIII student in SMP Negeri 4 Malang who was classified as intelligent but made many mistakes when completing the test. Data collection methods used were test and interview methods. The results show that students go through the step of generating ideas, clarifying ideas, assessing the reasonableness of ideas, and thinking complex on every step of problem solving, but at the look back step, students do not clarify the idea. Penelitian ini bertujuan untuk mendeskripsikan proses berpikir siswa dalam menyelesaikan soal matematika TIMSS materi besar sudut dalam bentuk geometris berdasarkan langkah penyelesaian masalah Polya yang dikaitkan dengan teori proses berpikir Swartz. Subjek penelitian adalah seorang siswa kelas VIII di SMP Negeri 4 Malang yang tergolong pandai, tetapi banyak melakukan kesalahan saat menyelesaikan soal tes. Metode pengumpulan data yang digunakan adalah metode tes dan wawancara. Hasil penelitian menunjukkan bahwa siswa dalam menyelesaikan soal TIMSS melalui tahap menghasilkan ide, mengklarifikasi ide, menilai kelayakan ide, dan berpikir kompleks pada setiap langkah penyelesaian masalah. Namun, pada tahap memeriksa kembali, siswa tidak melakukan pengklarifikasian ide.

  11. Improving attitudes toward mathematics learning with problem posing in class VIII

    Science.gov (United States)

    Vionita, Alfha; Purboningsih, Dyah

    2017-08-01

    This research is classroom action research which is collaborated to improve student's behavior toward math and mathematics learning at class VIII by using problem posing approach. The subject of research is all of students grade VIIIA which consist of 32 students. This research has been held on two period, first period is about 3 times meeting, and second period is about 4 times meeting. The instrument of this research is implementation of learning observation's guidance by using problem posing approach. Cycle test has been used to measure cognitive competence, and questionnaire to measure the students' behavior in mathematics learning process. The result of research shows the students' behavior has been improving after using problem posing approach. It is showed by the behavior's criteria of students that has increasing result from the average in first period to high in second period. Furthermore, the percentage of test result is also improve from 68,75% in first period to 78,13% in second period. On the other hand, the implementation of learning observation by using problem posing approach has also improving and it is showed by the average percentage of teacher's achievement in first period is 89,2% and student's achievement 85,8%. These results get increase in second period for both teacher and students' achievement which are 94,4% and 91,11%. As a result, students' behavior toward math learning process in class VIII has been improving by using problem posing approach.

  12. Indonesian Interference on English Language in VIII Grade Junior High School Students

    Directory of Open Access Journals (Sweden)

    Agustia Km Tri Sutrisna

    2018-01-01

    Full Text Available This study aims to determine the type of Indonesian interference found in English language among class VIII SMPK 2 Harapan Untal-Untal students. This research is done by analyzing the result of simple text translation done by the students of class VIII SMPK 2 Harapan Untal-Untal, then from the translation result will be analyzed what kind of interference that appeared. Methods of data collection in this study using observational research methods and literature. The data that have been collected in the form of simple translations from the students will be analyzed descriptively using related theories to find out what kind of interference found in the analysis. Further, in relating to interference, it will find a way out to reduce and even eliminate Indonesian interference itself. The results to be achieved in this research is recognize the level of Indonesian language interference in the use of English among the junior high school students, then find the practical efforts to be done so that interference does not increased. So, the use and English understanding can be done as much as possible. The finding of the paper found that 6 interference such as grammar structure, subject pronoun, adjectives, auxiliaries, preposition and word order.

  13. KEEFEKTIFAN MODEL PEMBELAJARAN PROBLEM BASED LEARNING BERNUANSA ETNOMATEMATIKA TERHADAP KEMAMPUAN PEMECAHAN MASALAH SISWA KELAS VIII

    Directory of Open Access Journals (Sweden)

    Dian Insani Abdullah

    2015-11-01

    Full Text Available Tujuan penelitian ini untuk mengetahui model pembelajaran PBL bernuansa etnomatematika efektif terhadap kemampuan pemecahan masalah siswa. Populasi dalam penelitian ini adalah siswa pada kelas VIII SMP N 1 Demak tahun pelajaran 2014/2015. Pengambilan sampel menggunakan cluster random sampling. Pengumpulan data dilakukan dengan metode dokumentasi, observasi, angket, dan tes. Analisis data menggunakan menggunakan uji One Sample T Test, uji proporsi, uji Independent Samples T Test dan uji regresi linear berganda. Hasil Penelitian menunjukkan bahwa (1 kemampuan pemecahan masalah siswa yang memperoleh pembelajaran model PBL bernuansa etnomatematika mencapai KKM, (2 kemampuan pemecahan masalah siswa yang memperoleh pembelajaran model PBL mencapai KKM (3 kemampuan pemecahan masalah siswa yang memperoleh pembelajaran model PBL bernuansa etnomatematika lebih tinggi daripada kemampuan pemecahan  masalah siswa dengan model PBL, (4 terdapat perbedaan sikap terhadap budaya lokal antara sebelum dan setelah diterapkan pembelajaran model PBL bernuansa etnomatematika dan (5 aktivitas belajar siswa dan sikap terhadap budaya lokal siswa berpengaruh terhadap kemampuan pemecahan masalah siswa, sehingga dapat disimpulkan model pembelajaran PBL bernuansa etnomatematika efektif terhadap kemampuan pemecahan masalah siswa kelas VIII.

  14. Evaluation of B&W UO2/ThO2 VIII experimental core: criticality and thermal disadvantage factor analysis

    Energy Technology Data Exchange (ETDEWEB)

    Carlo Parisi; Emanuele Negrenti

    2017-02-01

    In the framework of the OECD/NEA International Reactor Physics Experiment (IRPHE) Project, an evaluation of core VIII of the Babcock & Wilcox (B&W) Spectral Shift Control Reactor (SSCR) critical experiment program was performed. The SSCR concept, moderated and cooled by a variable mixture of heavy and light water, envisaged changing of the thermal neutron spectrum during the operation to encourage breeding and to sustain the core criticality. Core VIII contained 2188 fuel rods with 93% enriched UO2-ThO2 fuel in a moderator mixture of heavy and light water. The criticality experiment and measurements of the thermal disadvantage factor were evaluated.

  15. Immune tolerance induction with highly purified plasma-derived factor VIII containing von Willebrand factor in hemophilia A patients with high-responding inhibitors.

    Science.gov (United States)

    Orsini, Frédérique; Rotschild, Chantal; Beurrier, Philippe; Faradji, Albert; Goudemand, Jenny; Polack, Benoît

    2005-09-01

    We retrospectively evaluated the efficacy of immune tolerance induction (ITI) in a homogenous cohort of eight patients with constitutive severe hemophilia A with high-responding factor VIII (FVIII) inhibitors using Facteur VIII-LFB/Factane, a highly purified FVIII concentrate containing von Willebrand factor (VWF).

  16. 46 CFR 54.01-2 - Adoption of division 1 of section VIII of the ASME Boiler and Pressure Vessel Code.

    Science.gov (United States)

    2010-10-01

    ... Boiler and Pressure Vessel Code. 54.01-2 Section 54.01-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND... division 1 of section VIII of the ASME Boiler and Pressure Vessel Code. (a) Pressure vessels shall be designed, constructed, and inspected in accordance with section VIII of the ASME Boiler and Pressure Vessel...

  17. A DFT study to unravel the ligand exchange kinetics and thermodynamics of Os(VIII) oxo/hydroxido/aqua complexes in aqueous matrices.

    Science.gov (United States)

    van Niekerk, Daniel M E; Gerber, Wilhelmus J; Koch, Klaus R

    2016-04-28

    The Os(VIII) oxo/hydroxido complexes that are abundant in mild to relatively concentrated basic aqueous solutions are Os(VIII)O4, [Os(VIII)O4(OH)](-) and two cis-[Os(VIII)O4(OH)2](2-) species. Os(VIII) complexes that contain water ligands are thermodynamically unfavoured w.r.t. the abovementioned species. Os(VIII)O4 reacts with hydroxide in two, consecutive, elementary coordination sphere expansion steps to form the [Os(VIII)O4(OH)](-) complex and then the cis-[Os(VIII)O4(OH)2](2-) species. The Gibbs energy of activation for both reactions, in the forward and reverse direction, are in the range of 6-12 kcal mol(-1) and are relatively close to diffusion-controlled. The thermodynamic driving force of the first reaction is the bonding energy of the Os(VIII)-OH metal-hydroxido ligand, while of the second reaction it is the relatively large hydration energy of the doubly-charged cis-[Os(VIII)O4(OH)2](2-) product compared to the singly-charged reactants. The DFT-calculated (PBE-D3 functional) in the simulated aqueous phase (COSMO) is -2.4 kcal mol(-1) for the first reaction and -0.6 kcal mol(-1) for the second reaction and agree to within 1 kcal mol(-1) with reported experimental values, at -2.7 and 0.3 kcal mol(-1) respectively. From QTAIM and EDA analyses it is deduced that the Os(VIII)[double bond, length as m-dash]O bonding interactions are ionic (closed-shell) and that Os(VIII)-OH bonding interactions are polar covalent (dative). In contrast to QTAIM, NCI analysis allowed for the identification of relatively weak intramolecular hydrogen bonding interactions between neighbouring oxo and hydroxido ligands in both [Os(VIII)O4(OH)](-) and cis-[Os(VIII)O4(OH)2](2-) complexes.

  18. Incidence of factor VIII inhibitor development in severe hemophilia A patients treated only with one brand of highly purified plasma-derived concentrate.

    Science.gov (United States)

    Guérois, C; Laurian, Y; Rothschild, C; Parquet-Gernez, A; Duclos, A M; Négrier, C; Vicariot, M; Fimbel, B; Fressinaud, E; Fiks-Sigaud, M

    1995-02-01

    The incidence of factor VIII inhibitor was studied in a cohort of 56 previously untreated patients with severe hemophilia A (factor VIII below 1 U/dl). They received only one brand of highly purified factor VIII concentrate (HPSD-VIII) prepared by conventional chromatography with a solvent-detergent step for viral inactivation. Follow-up since the first infusion of HPSD-VIII was from 1 to 76 months (mean = 29) and cumulative exposure days (CED) from 1 to over 100 (median = 26). Five patients (9%) developed an inhibitor after 6 to 19 CED, only one being a high responder (2%), showing a low incidence of inhibitor compared with previous studies using high purity plasma-derived or recombinant products.

  19. Purification and characterization of factor VIII 1,689-Cys: a nonfunctional cofactor occurring in a patient with severe hemophilia A.

    Science.gov (United States)

    O'Brien, D P; Tuddenham, E G

    1989-06-01

    We have purified the factor VIII from a CRM+ Hemophilia A plasma (90 U/dL VIII:Ag but 0 U/dL VIII:C) and analyzed the protein before and after thrombin activation by Western blotting with monoclonal antibodies (MoAbs). Normal or patient citrated plasma was ultracentrifuged, cryo-ethanol-precipitated and chromatographed on Sepharose 6B. The void volume fractions were reduced and subjected to ion exchange chromatography yielding material of specific activity approximately 1,000 U/mg protein (VIII:C or VIII:Ag). Factor VIII purified in this way from normal plasma is fully activatable by thrombin with proteolytic fragmentation as previously described by F. Rotblat et al (Biochemistry 24: 4294, 1985). Factor VIII 1,689-Cys has the normal distribution of factor VIII light and heavy chains prior to thrombin activation. After exposure to thrombin the heavy chain polypeptides were fully proteolysed but the light chain was totally resistant to cleavage. This is consistent with the demonstration in the patient's leucocyte DNA of a C to T transition in codon 1,689 converting Arg to Cys at the light chain thrombin cleavage site as previously described by J. Gitschier et al (Blood 72:1022, 1988). Uncleaved light chain of Factor VIII 1,689-Cys is not released from von Willebrand factor (vWF) by thrombin, but this is not the sole cause of the functional defect since the protein purified free of vWF has no coagulant activity. We conclude that the functional defect in factor VIII 1,689-Cys is a consequence of failure to release the acidic peptide from the light chain upon thrombin activation.

  20. Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry

    Science.gov (United States)

    Sevy, Alexander M.; Healey, John F.; Deng, Wei; Spiegel, P. Clint; Meeks, Shannon L.; Li, Renhao

    2014-01-01

    Summary Background The development of anti-factor VIII (fVIII) antibodies (inhibitors) is a significant complication in the management of patients with hemophilia A, leading to significant increases in morbidity and treatment cost. Using a panel of anti-fVIII monoclonal antibodies (MAbs) to different epitopes on fVIII, we recently have shown that epitope specificity, inhibitor kinetics, and time to maximum inhibition are more important than inhibitor titer in predicting response to fVIII and the combination of fVIII and recombinant factor VIIa. In particular, a subset of high-titer inhibitors responded to high dose fVIII, which would not be predicted based on their inhibitor titer alone. Thus the ability to quickly map the epitope spectrum of patient plasma using a clinically feasible assay may fundamentally change how clinicians approach the treatment of high-titer inhibitor patients. Objectives To map the epitopes of anti-fVIII MAbs, of which 3 are classical inhibitors and one non-classical, using hydrogen-deuterium exchange coupled with liquid chromatography-mass spectrometry (HDX-MS). Methods Binding epitopes of 4 MAbs targeting fVIII C2 domain were mapped using HDX-MS. Results The epitopes determined by HDX-MS are consistent with those obtained earlier through structural characterization and antibody competition assays. In addition classical and non-classical inhibitor epitopes could be distinguished using a limited subset of C2-derived peptic fragments. Conclusion Our results demonstrate the effectiveness and robustness of the HDX-MS method for epitope mapping and suggest a potential role of rapid mapping of fVIII inhibitor epitopes in facilitating individualized treatment of inhibitor patients. PMID:24152306

  1. Helminth parasites of wild boar, Sus scrofa, in Iran.

    Science.gov (United States)

    Eslami, A; Farsad-Hamdi, S

    1992-04-01

    Fifty-seven wild boars (Sus scrofa) from protected regions of Iran were examined for helminths. Sixteen species of helminths were collected; there were ten nematodes, one acanthocephalan, two trematodes and three larval cestodes. New host and distribution records were established for all helminths except of Taenia solium cysticerci. Wild boar shared nine of these helminths with domestic pigs, six with ruminants and three with human beings in Iran. Metastrongylus pudendotectus and M. salmi are reported for the first time from Iran.

  2. La tibia y sus deformidades congénitas

    Directory of Open Access Journals (Sweden)

    Valentín Malagón Castro

    1955-06-01

    Full Text Available El presente estudio sobre la Tibia y sus anomalías congénitas lo hemos dividido en 2 grandes capítulos. En el primero bosquejamos sintéticamente los caracteres anatómicos y radiológicos del hueso tibial sano. En el segundo, pasamos revista a las deformidades congénitas de la Tibia: Ausencia, Amputaciones, Incurvaciones, Pseudoartrosis, etc.

  3. Material test data of SUS304 welded joints

    Energy Technology Data Exchange (ETDEWEB)

    Asayama, Tai [Japan Nuclear Cycle Development Inst., Oarai, Ibaraki (Japan). Oarai Engineering Center; Kawakami, Tomohiro [Nuclear Energy System Incorporation, Tokyo (Japan)

    1999-10-01

    This report summarizes the material test data of SUS304 welded joints. Numbers of the data are as follows: Tensile tests 71 (Post-irradiation: 39, Others: 32), Creep tests 77 (Post-irradiation: 20, Others: 57), Fatigue tests 50 (Post-irradiation: 0), Creep-fatigue tests 14 (Post-irradiation: 0). This report consists of the printouts from 'the structural material data processing system'. (author)

  4. Analysis of factor VIII gene inversions in 164 unrelated hemophilia A families

    Energy Technology Data Exchange (ETDEWEB)

    Vnencak-Jones, L.; Phillips, J.A. III; Janco, R.L. [Vanderbilt Univ. School of Medicine, Nashville, TN (United States)] [and others

    1994-09-01

    Hemophilia A is an X-linked recessive disease with variable phenotype and both heterogeneous and wide spread mutations in the factor VIII (F8) gene. As a result, diagnostic carrier or prenatal testing often relies upon laborious DNA linkage analysis. Recently, inversion mutations resulting from an intrachromosomal recombination between DNA sequences in one of two A genes {approximately}500 kb upstream from the F8 gene and a homologous A gene in intron 22 of the F8 gene were identified and found in 45% of severe hemophiliacs. We have analyzed banked DNA collected since 1986 from affected males or obligate carrier females representing 164 unrelated hemophilia A families. The disease was sporadic in 37%, familial in 54% and in 10% of families incomplete information was given. A unique deletion was identified in 1/164, a normal pattern was observed in 110/164 (67%), and 53/164 (32%) families had inversion mutations with 43/53 (81%) involving the distal A gene (R3 pattern) and 10/53 (19%) involving the proximal A gene (R2 pattern). While 19% of all rearrangements were R2, in 35 families with severe disease (< 1% VIII:C activity) all 16 rearrangements seen were R3. In 18 families with the R3 pattern and known activities, 16 (89%) had levels < 1%, with the remaining 2 families having {le} 2.4% activity. Further, 18 referrals specifically noted the production of inhibitors and 8/18 (45%) had the R3 pattern. Our findings demonstrate that the R3 inversion mutation patterns is (1) only seen with VIII:C activity levels of {le} 2.4%, (2) seen in 46% of families with severe hemophilia, (3) seen in 45% of hemophiliacs known to have inhibitors, (4) not correlated with sporadic or familial disease and (5) not in disequilibrium with the Bcl I or Taq I intron 18 or ST14 polymorphisms. Finally, in families positive for an inversion mutation, direct testing offers a highly accurate and less expensive alternative to DNA linkage analysis.

  5. Keefektifan Experiential Learning Berbantuan Origami Terhadap Kemampuan Keruangan Siswa Kelas VIII

    Directory of Open Access Journals (Sweden)

    Isnaeni Umi Machromah

    2014-11-01

    Full Text Available AbstrakPenelitian eksperimen ini bertujuan untuk mengetahui keefektifan pembelajaran Experiential Learning berbantuan origami terhadap kemampuan keruangan siswa dengan kualifikasi keefektifan yang telah ditentukan. Populasi yaitu siswa kelas VIII SMP Negeri 3 Colomadu tahun pelajaran 2012/2013. Sampel diambil secara simple random sampling. Hasil penelitian ini yaitu: (1 Uji proporsi ketuntasan belajar menunjukkan siswa kelompok eksperimen telah mencapai ketuntasan belajar; (2 Uji perbedaan dua rata-rata menghasilkan simpulan bahwa rata-rata hasil post-test kemam-puan keruangan siswa kelompok eksperimen lebih dari kelompok kontrol; (3 Analisis re-gresi menunjukkan bahwa motivasi belajar siswa memberikan pengaruh positif sebesar 49,3% terhadap kemampuan keruangan siswa; (4 Uji gain ternormalisasi menunjukkan terdapat peningkatan kemampuan keruangan siswa secara signifikan pada kategaori sedang untuk kelompok eksperimen dan kategori rendah untuk kelompok kontrol. Simpulan yang diperoleh yaitu Experiential Learning berbantuan origami efektif terhadap kemampuan keruangan siswa kelas VIII. AbstractThis experiment research aims to determine the effectiveness of Experiential Learning with Origami to the students’s spatial abilities by the criteria of effectiveness. The population of this research is students of grade VIII of SMP Negeri 3 Colomadu 2012/2013 academic year. Independent variables used in this research are learning by Experiential Learning with origami and student’s motivation. While the dependent variable is the student’s spatial abilities. This research is using documentation, spatial abilities’s test, dan motivation’s scale for collecting data method. Result of this research are: (1 proportion test show that the experiment group has reached mastering of learning clasically and personally; (2 result of spatial ablities’s post test in experiment group better than control group; (3 result of regretion shows that student

  6. Factor VIII S373L: mutation at P1' site confers thrombin cleavage resistance, causing mild haemophilia A.

    Science.gov (United States)

    Johnson, D J; Pemberton, S; Acquila, M; Mori, P G; Tuddenham, E G; O'Brien, D P

    1994-04-01

    A novel CRM+ mutation, factor VIII position 373 serine to leucine substitution (FVIII 373-Leu) was identified during a survey of Factor VIII (FVIII) mutations. We have purified the variant protein from the patient's plasma in order to allow further characterisation of the molecule. The CRM+ plasma contained 120% Factor VIII antigen (FVIII:Ag) and 6% Factor VIII coagulant activity (FVIII:C). After purification the mutant FVIII was subjected to thrombin proteolysis, and was thereby activated 5.6-fold compared with 7-fold for wild type molecule. Subsequently, spontaneous inactivation of the mutant was much slower than noted for wild type FVIII. Western blot analysis using monoclonal antibodies demonstrated that thrombin cleavage of FVIII 373-Leu at positions 740 and 1689 were normal but that cleavage at position 372 was completely absent. Crystallographic coordinates of the active site of thrombin complexed to fibrinopeptide A were used to explore possible mechanistic reasons for the failure of thrombin to cleave the mutant FVIII at position 372. Steric hindrance between the mutant side chain and the side chain of the P1 residue was apparent. We conclude that the functional defect of FVIII 373-Leu results from the inability of thrombin to cleave the mutant at position 372-373, and propose that this is due to steric hindrance by the side chain of leucine 373, preventing correct formation of the enzyme substrate complex.

  7. 75 FR 36426 - Legislative Changes to Nursing Student Loan Program Authorized Under Title VIII of the Public...

    Science.gov (United States)

    2010-06-25

    ... Changes to Nursing Student Loan Program Authorized Under Title VIII of the Public Health Service Act....) 111-148. Section 5202 of the ACA changes the Nursing Student Loan (NSL) program by: (1) Increasing the... degree in nursing. Below are details on how the ACA changes Sections 836(a), 836(b)(1), and 836(b)(3) of...

  8. Joint bleeds increase the inhibitor response to human factor VIII in a rat model of severe haemophilia A

    DEFF Research Database (Denmark)

    Löfgren, Karin Maria; Søndergaard, H.; Skov, Søren

    2016-01-01

    Introduction The most serious complication in haemophilia A (HA) replacement therapy with coagulation factor VIII (FVIII) is neutralizing antibodies, i.e. inhibitors. It has been hypothesized that danger signals generated during a bleed might have an adjuvant effect on the immune response to FVIII...

  9. Evaluation of the biological differences of canine and human factor VIII in gene delivery: Implications in human hemophilia treatment

    Science.gov (United States)

    The canine is the most important large animal model for testing novel hemophilia A(HA) treatment. It is often necessary to use canine factor VIII (cFIII) gene or protein for the evaluation of HA treatment in the canine model. However, the different biological properties between cFVIII and human FVII...

  10. Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A

    NARCIS (Netherlands)

    Collins, P. W.; Blanchette, V. S.; Fischer, K.; Bjorkman, S.; Oh, M.; Fritsch, S.; Schroth, P.; Spotts, G.; Astermark, J.; Ewenstein, B.

    Background: The role of prophylactic factor VIII (FVIII) to decrease hemophilic bleeding and arthropathy is well established. The rationale for this strategy is to convert patients with severe hemophilia A to a moderate clinical phenotype by reducing time spent with a FVIII level <1 IU dL(-1).

  11. Exact Bianchi type-II, VIII and IX perfect fluid cosmological models in Saez-Ballester theory of gravitation

    Science.gov (United States)

    Rao, V. U. M.; Vijaya Santhi, M.; Vinutha, T.

    2008-09-01

    Exact Bianchi type-II, VIII and IX cosmological models are obtained in a scalar tensor theory proposed by Saez and Ballester (Phys. Lett. A 113:467, 1986) with perfect fluid as a source. Some physical and geometrical properties of the models are studied. It is observed that the models are free from initial singularities and they are expanding with time.

  12. Analysis of factor VIII inhibitors in a haemophilia A patient with an Arg(593)-> Cys mutation using phage display

    NARCIS (Netherlands)

    Bril, Wendy S.; Turenhout, Ellen A. M.; Kaijen, Paul H. P.; van den Brink, Edward N.; Koopman, Maria M. W.; Peters, Marjolein; Voorberg, Jan

    2002-01-01

    We characterized anti-factor VIII antibodies in a mild haemophilia A patient with an Arg(593)-->Cys mutation in the A2 domain, using V gene phage-display technology. All isolated single-chain variable-domain antibody fragments were directed against residues Arg(484)-Ile(508), a binding site for

  13. Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.

    Science.gov (United States)

    Pantazatos, Dionysios; Gessner, Christopher R; Woods, Virgil L; Gilbert, Gary E

    2014-08-01

    Factor VIII enhances the catalytic activity of Factor IXa in a membrane-bound enzyme complex and both proteins are necessary to prevent haemophilia. Tandem lectin-like C domains mediate the membrane binding of Factor VIII and membrane-interactive residues have been identified. However, the available data provide little insight into the dynamic changes that occur upon membrane binding. We used time-based hydrogen-deuterium exchange MS to evaluate the dynamics of FVIII-C2 (Factor VIII C2 domain) alone and when membrane bound. The results confirm the participation of previously identified membrane-interactive loops in the binding mechanism. In addition, they indicate that a long peptide segment, encompassing a membrane-interactive loop and strands of the β-barrel core, is remarkably dynamic prior to membrane binding. The flexibility is reduced following membrane binding. In addition, regions that interact with the A1 and C1 domains have reduced solvent exchange. Thus the isolated C2 domain has extensive flexibility that is subject to stabilization and could be related to interactions between domains as well as between Factor VIII and Factor IXa or Factor X. These results confirm that the proposed membrane-binding loops of the FVIII-C2 interact with the membrane in a manner that leads to protection from solvent exposure.

  14. Effectiveness of Peer Tutoring in Learning English among Tutors and Tutees of Class VIII Students in Kancheepuram DT

    Science.gov (United States)

    Marieswari, M.; Prema, N.

    2016-01-01

    The peer who teaches to their mates is peer tutoring. It is a common instructional strategy used in classrooms. The aim of this study is to know whether there is any improvement in achievement marks of tutors and tutees after the process of peer tutoring. Class VIII students were selected as the sample for the present experimental study. The…

  15. Paducah-Louisville Consortium. Project VIII: Focus on Dropouts... A New Design. Final Evaluation Report, 1971-72.

    Science.gov (United States)

    Lyne, Evelyn

    Project VIII is an innovative behavioral science-oriented educational program for potential dropouts. It is designed to reduce the dropout rate in grades 9 through 12, increase attendance in grades 7 through 12, decrease discipline referrals and suspensions, increase reading and math achievement in grades 3 through 11, and improve the student's…

  16. Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice

    NARCIS (Netherlands)

    Wroblewska, Aleksandra; van Haren, Simon D.; Herczenik, Eszter; Kaijen, Paul; Ruminska, Aleksandra; Jin, Sheng-Yu; Zheng, X. Long; van den Biggelaar, Maartje; ten Brinke, Anja; Meijer, Alexander B.; Voorberg, Jan

    2012-01-01

    Development of neutralizing Abs to blood coagulation factor VIII (FVIII) provides a major complication in hemophilia care. In this study we explored whether modulation of the uptake of FVIII by APCs can reduce its intrinsic immunogenicity. Endocytosis of FVIII by professional APCs is significantly

  17. Desempenho de cordeiros Santa Inês puros e cruzas Santa Inês com Texel, Ile de France e Bergamácia Performance of Santa Inês lambs and its crosses with Texel, Ile de France e Bergamacia lambs

    Directory of Open Access Journals (Sweden)

    Iraides Ferreira Furusho-Garcia

    2004-12-01

    Full Text Available O trabalho foi desenvolvido com o objetivo de estudar o efeito do sexo dos animais, do grupo genético e do peso de abate no desempenho de animais confinados. Foram utilizados 103 cordeiros, machos e fêmeas, Santa Inês puros (SS e cruzas Santa Inês com Texel (TS, Ile de France (FS e Bergamácia (BS, confinados em gaiolas individuais. Mediram-se a dieta fornecida e as sobras diárias, para cálculo do consumo de matéria seca (MS, energia metabolizável (EM, proteína digestível (PD e fibra em detergente neutro (FDN. Os cordeiros foram abatidos em quatro pesos: 15, 25, 35 e 45 kg de peso vivo. Avaliaram-se o ganho de peso diário (GPD, o número de dias no confinamento (ND, a conversão alimentar (CA e o consumo de MS, PD, EM e FDN, nas três fases de crescimento: 15 a 25 kg (1, 25 a 35 kg (2 e 35 a 45 kg (3. Também foram avaliados as idades de abate (IA, o peso do corpo vazio (PCVZ e rendimento de carcaça (RC. Aos 35 e 45 kg, os cordeiros TS e FS apresentaram IA inferiores e as cordeiras SS, IA superiores. O ND dos cordeiros BS de 35 a 45 kg foi maior que dos TS. Aos 35 e 45 kg, o PCVZ dos cordeiros TS e FS foram menores. Os melhores GPD foram dos cordeiros TS, seguidos do FS e SS. Os consumos de MS, PD, EM e FDN foram semelhantes entre os grupos genéticos, nas fases 1 e 2 de crescimento. Verificou-se que os cordeiros TS tenderam a aumentar o consumo, com o incremento de peso, enquanto os outros grupos tenderam a diminuir. A CA elevou-se com o aumento de peso, com exceção dos machos FS. Os machos não apresentaram diferenças na CA entre os grupos genéticos, entretanto, as fêmeas TS e FS apresentaram valores melhores. Aos 35 e 45 kg, as fêmeas apresentaram maiores RC que os machos. Aos 35 kg, os melhores RC foram dos machos TS.The work was carried out to evaluate the effect of animal sex, genetic group and slaugher weight on fedlot lambs performance. One hundred and three male and female lambs, purebred Santa Inês (SS and crosses

  18. X-ray spectral line coincidences between fluorine VIII (and IX) and transition metal lines

    International Nuclear Information System (INIS)

    Charatis, G.; Rockett, P.D.; Burkhalter, P.G.

    1983-01-01

    X-ray spectroscopy was performed in the 12 to 15 A region, recording L-shell lines from selected laser-irradiated transition metals. Line coincidences and near coincidences were identified between Fe, Cr, Mn, and Ni L-spectra, and F VIII and F IX K-shell lines. Wavelengths were determined to accuracies of 1 to 3 mA and will be utilized in selecting potential pumping candidates in future x-ray lasing schemes. High-resolution x-ray spectra were collected under controlled illumination and target conditions using 1.05 μm and 0.527 μm laser excitation with the KMS CHROMA laser

  19. PENERAPAN PENDEKATAN CINEMATHERAPY UNTUK MENINGKATKAN PERILAKU PROSOSIAL PADA SISWA KELAS VIII DI BOSOWA INTERNATIONAL SCHOOL MAKASSAR

    Directory of Open Access Journals (Sweden)

    Haeruddin Niva

    2016-06-01

    Full Text Available The objectives of the research are: (i to know the prosocial behavioral level of the students in Bosowa International School Makassar before and after giving cinematography approach, and (ii to know whether or not the approach is able to enhance the prosocial behavior of the students in Bosowa International School Makassar. The research is a quantitative research using experimental method. The research design used is quasi experimental design with non-equivalent control group design. The data collection technique applied is scale and FGD (Focus Group Discussion. The findings shows that (i the prosocial behavioral level of the students was low in pretest while after giving treatment there were significant increase to the prosocial behavior in the experimental group, and (ii the cinematography approach was able to increase the prosocial behavior of the Grade VIII students in Bosowa Internatinal School Makassar. 

  20. [Immune mechanisms involved in the development and eradication of anti-factor VIII alloantibodies in hemophilia].

    Science.gov (United States)

    Ishiguro, Akira

    2011-01-01

    Hemophilia A is an X-linked hereditary bleeding disorder caused by a congenital deficiency in blood coagulation factor VIII (FVIII). Therapy to prevent or treat bleeding is replacement of FVIII. The most significant complication of treatment in patients with hemophilia A is the development of alloantibodies that inhibit FVIII activity, termed inhibitors. In the presence of inhibitors, replacement of the missing clotting factor with FVIII preparations becomes less effective. Once replacement therapy is ineffective, morbidity increases. It remains unsolved to prevent inhibitor formation. The only strategy is long-term administration of a large quantity of FVIII in an attempt to eradicate the inhibitors through immune tolerance. However, little is known about the mechanisms involved in the induction of tolerance. This review will focus on the current understanding of why inhibitors develop and can be eradicated. The development of inhibitors by intravenous infusions of FVIII without adjuvant poses an intriguing challenge to immunologists.

  1. Evaluation of Neutron Reactions on Iron Isotopes for CIELO and ENDF/B-VIII.0

    Science.gov (United States)

    Herman, M.; Trkov, A.; Capote, R.; Nobre, G. P. A.; Brown, D. A.; Arcilla, R.; Danon, Y.; Plompen, A.; Mughabghab, S. F.; Jing, Q.; Zhigang, G.; Tingjin, L.; Hanlin, L.; Xichao, R.; Leal, L.; Carlson, B. V.; Kawano, T.; Sin, M.; Simakov, S. P.; Guber, K.

    2018-02-01

    A new suite of evaluations for 54,56,57,58Fe has been developed in the framework of the CIELO international collaboration. New resolved resonance ranges were evaluated for 54Fe and 57Fe, while modifications were applied to resonances in 56Fe. The low energy part of the 56Fe file is almost totally based on measurements. At higher energies in 56Fe and in the whole fast neutron range for minor isotopes the evaluation consists of model predictions carefully adjusted to available experimental data. We also make use of the high quality and well experimentally-constrained dosimetry evaluations from the IRDFF library. Special attention was dedicated to the elastic angular distributions, which were found to affect results of the integral benchmarking. The new set of iron evaluations was developed in concert with other CIELO evaluations and they were tested together in the integral experiments before being adopted for the ENDF/B-VIII.0 library.

  2. MENINGKATKAN TANGGUNG JAWAB SOSIAL SISWA KELAS VIII MELALUI LAYANAN BIMBINGAN KELOMPOK

    Directory of Open Access Journals (Sweden)

    Ummi Farikhatun Nisa

    2012-12-01

    Full Text Available The purpose of this research was to determine the efforts and success in improving students' social responsibility through group counseling services. Type of research used action research. Subjects were 12 students who had low social responsibility and being. Data collection technique used were psychological scales and observation. Data analysis techniques used are non-parametric statistics with the Wilcoxon test. Based on the calculations for the Wilcoxon test, a small amount of levels or Z value was 78.0. While Ztabel for n = 12 with an error level of 5% value is 14. So Z 78.0> 14.0 Ztabel or imply hypothesis accepted. These results demonstrate social responsibility of students prior to obtaining counseling services group at 51.93% (low. After following the guidance services at 81.51% (high. Conclusions from this research is a social responsibility to the students of class VIII SMP Putra Bangsa Bantarkawung increase after getting tutoring services group.

  3. Symposium by NATO Defense Research Group Panel VIII on Computer-Based Instruction in Military Environments

    CERN Document Server

    Weddle, Peter

    1987-01-01

    This collection of papers is the result of a symposium sponsored by NATO's Defense Research Group Panel VIII in the Spring of 1985. The symposium came into being when it became obvious to the NATO countries that research, development and utilization of advanced technologies for training was the best means of increasing both training effectiveness and efficiency. This symposium was the second in a series of three devoted to training. The series was structured to cover all aspects of training. The first series addressed the value of training, the second one dealt with the application of training technologies and the third and last of the series focused on academic issues concerned with the effect of prior learning on subsequent learning. The fact that a major American publisher has determined that computer based instruction is the technology of greatest interest to the NATO community is not surprising. Advances in microprocessor technology have revolutionized both how and where we train. During this symposium t...

  4. PENGARUH PENERAPAN PENDEKATAN REALISTIK SETTING KOOPERATIF TERHADAP KEMAMPUAN KOMUNIKASI MATEMATIKA SISWA KELAS VIII

    Directory of Open Access Journals (Sweden)

    Andi Alim Syahri

    2017-12-01

    This study aims to determine the effect of learning mathematics through Realistic Cooperative Setting Approach to students mathematics’ communication skill of VIII grade of SMP Muhammadiyah 6 Makassar academic year 2017/2018. This Pre-Experiment research involved one class as a case study without control class with One-Group Pre-Test and Post-Test design. The subject of this research were 33 student’s of VIIIB consist of 12 male and 21 female.  The research were conducted in 6 meeting. The instrument of this research were test to saw the students’ written communication ability, observation sheet to observed students’ oral communication ability during the learning process, observation sheet of learning implementation to observed teacher ability in managed learning process in appropriate with RPP and questionnaire to measured the student response in learning trough Realistic Cooperative Setting Approach. The result of this research showed that: (1 most of the students’ mathematical communication skill before and after taught by Realistic Cooperative Setting Approach were successive 6,15 and 29,93 from the ideal 60 with average normalized gain score 0.44  means that increase was in the medium category, (2 the average percentage of frequency of the students’ oral communication ability was 76,63%, (3 the average implementation of learning was 3,6 in good category, and (4 the questionnaire showed that students’ response to Realistic Cooperative Setting Approach inclined to be positive with  percentage 88%. From the result of this research, can be concluded that the application of Realistic Cooperative Setting Approach influenced the students mathematics’ communication skill of VIII grade of SMP Muhammadiyah 6 Makassar.

  5. Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery

    Directory of Open Access Journals (Sweden)

    Harrison C Brown

    2014-01-01

    Full Text Available Clinical data support the feasibility and safety of adeno-associated viral (AAV vectors in gene therapy applications. Despite several clinical trials of AAV-based gene transfer for hemophilia B, a unique set of obstacles impede the development of a similar approach for hemophilia A. These include (i the size of the factor VIII (fVIII transgene, (ii humoral immune responses to fVIII, (iii inefficient biosynthesis of human fVIII, and (iv AAV vector immunity. Through bioengineering approaches, a novel fVIII molecule, designated ET3, was developed and shown to improve biosynthetic efficiency 10- to 100-fold. In this study, the utility of ET3 was assessed in the context of liver-directed, AAV-mediated gene transfer into hemophilia A mice. Due to the large size of the expression cassette, AAV-ET3 genomes packaged into viral particles as partial genome fragments. Despite this potential limitation, a single peripheral vein administration of AAV-ET3 into immune-competent hemophilia A mice resulted in correction of the fVIII deficiency at lower vector doses than previously reported for similarly oversized AAV-fVIII vectors. Therefore, ET3 appears to improve vector potency and mitigate at least one of the critical barriers to AAV-based clinical gene therapy for hemophilia A.

  6. Factor VIII brand and the incidence of factor VIII inhibitors in previously untreated UK children with severe hemophilia A, 2000-2011

    Science.gov (United States)

    Palmer, Benedict P.; Chalmers, Elizabeth A.; Hart, Daniel P.; Liesner, Ri; Rangarajan, Savita; Talks, Katherine; Williams, Michael; Hay, Charles R. M.

    2014-01-01

    The effect of recombinant factor VIII (rFVIII) brand on inhibitor development was investigated in all 407 severe hemophilia A previously untreated patients born in the United Kingdom (UK) between 1 January 2000 and 31 December 2011. Eighty-eight (22%) had been in the RODIN study. Information was extracted from the National Haemophilia Database. Because exposure days (EDs) were not known for some patients, time from first treatment was used as a surrogate for rFVIII exposure. An inhibitor developed in 118 (29%) patients, 60 high and 58 low titer, after a median (interquartile range) of 7.8 (3.3-13.5) months from first exposure and 16 (9-30) EDs. Of 128 patients treated with Kogenate Bayer/Helixate NexGen, 45 (35.2%, 95% confidence interval [CI] 27.4-43.8) developed an inhibitor compared with 42/172 (24.4%, 95% CI 18.6% to 31.4%) with Advate (P = .04). The adjusted hazard ratio (HR) (95% CI) for Kogenate Bayer/Helixate NexGen compared with Advate was 2.14 (1.12-4.10) (P = .02) for high titer and 1.75 (1.11-2.76) (P = .02) for all inhibitors. When excluding UK-RODIN patients, the adjusted HR (95% CI) for high-titer inhibitors was 2.00 (0.93-4.34) (P = .08). ReFacto AF was associated with a higher incidence of all, but not high-titer, inhibitors than Advate. These results will help inform debate around the relative immunogenicity and use of rFVIII brands. PMID:25339360

  7. Factor VIII brand and the incidence of factor VIII inhibitors in previously untreated UK children with severe hemophilia A, 2000-2011.

    Science.gov (United States)

    Collins, Peter W; Palmer, Benedict P; Chalmers, Elizabeth A; Hart, Daniel P; Liesner, Ri; Rangarajan, Savita; Talks, Katherine; Williams, Michael; Hay, Charles R M

    2014-11-27

    The effect of recombinant factor VIII (rFVIII) brand on inhibitor development was investigated in all 407 severe hemophilia A previously untreated patients born in the United Kingdom (UK) between 1 January 2000 and 31 December 2011. Eighty-eight (22%) had been in the RODIN study. Information was extracted from the National Haemophilia Database. Because exposure days (EDs) were not known for some patients, time from first treatment was used as a surrogate for rFVIII exposure. An inhibitor developed in 118 (29%) patients, 60 high and 58 low titer, after a median (interquartile range) of 7.8 (3.3-13.5) months from first exposure and 16 (9-30) EDs. Of 128 patients treated with Kogenate Bayer/Helixate NexGen, 45 (35.2%, 95% confidence interval [CI] 27.4-43.8) developed an inhibitor compared with 42/172 (24.4%, 95% CI 18.6% to 31.4%) with Advate (P = .04). The adjusted hazard ratio (HR) (95% CI) for Kogenate Bayer/Helixate NexGen compared with Advate was 2.14 (1.12-4.10) (P = .02) for high titer and 1.75 (1.11-2.76) (P = .02) for all inhibitors. When excluding UK-RODIN patients, the adjusted HR (95% CI) for high-titer inhibitors was 2.00 (0.93-4.34) (P = .08). ReFacto AF was associated with a higher incidence of all, but not high-titer, inhibitors than Advate. These results will help inform debate around the relative immunogenicity and use of rFVIII brands. © 2014 by The American Society of Hematology.

  8. LA INSPECCIÓN TRIBUTARIA Y SUS AVANCES

    OpenAIRE

    VICEDO ARMIÑANA, RAFAEL

    2014-01-01

    Para llevar a cabo y hacer efectiva su potestad de gestión, las entidades locales necesitan una autonomía económico-financiera, debiendo de disponer de medios tributarios y patrimoniales suficientes para el cumplimiento de sus funciones, tal y como reconoce el artículo 142 de la Constitución Española, de acuerdo con el cual, las Haciendas Locales deberán disponer de los medios suficientes para el desarrollo de las funciones que la Ley atribuye a las Corporaciones respectivas, y se nutrirán fu...

  9. Intestinal protozoa in wild boars (Sus scrofa) in western Iran.

    Science.gov (United States)

    Solaymani-Mohammadi, S; Rezaian, M; Hooshyar, H; Mowlavi, G R; Babaei, Z; Anwar, M A

    2004-10-01

    A total of 12 gastrointestinal tracts of wild boars (Sus scrofa) from western Iran (Luristan) were examined for protozoan infection between September 2000 and November 2001. Of 12 boars examined, 67% harbored one or more species of the following protozoa: Balantidium coli (25%), Tritrichomonas suis (25%), Blastocystis sp. (25%), Entamoeba polecki (17%), Entamoeba suis (8%), Iodamoeba butschlii (17%), and Chilomastix mesnili (8%). Four of these protozoan species also are reported in humans, and persons living in rural areas where wild boars are abundant should take precaution to avoid infection.

  10. Kant, sus maestros y los maestros de la humanidad

    OpenAIRE

    Ríos Acevedo, Clara Inés

    1999-01-01

    A instancias de Newton y Rousseau, con sus planteamientos sobre la gravitación universal y la rivindicación del sentimiento y la moralidad, respectivameente, Kant se ocupó de la insociable sociabilidad del ser humano, que genera la dialéctica de la guerra y la paz, antítesis de la ley moral y premisa de todo sistema social; del problema de la paz mundial, promulgando la necesidad de un organismo legal internacional que agrupara todos los Estados del planeta, para así disminuir las guerras y p...

  11. Padres hombres custodios - PHC: la paternidad, sus alcances y motivaciones

    OpenAIRE

    Fierro Barahona, José Gustavo; Ruíz Gómez, Marina Stella

    2015-01-01

    Esta investigación comprendió las concepciones sobre paternidad presentes en los padres hombres al solicitar la custodia de sus hijas e hijos menores de siete años ante el ICBF de la ciudad de Cali con un diseño cualitativo de aproximación fenomenológica, se utilizó el instrumento de entrevista en profundidad con cinco padres hombres custodios - PHC. Los resultados se presentaron en relación a las distinciones expresadas por los PHC acerca de las razones que los llevó a solicit...

  12. Entusiastas, aficionados y espectadores: sus valores, motivaciones y compromiso

    OpenAIRE

    Torregrosa, Miquel; Cruz, Jaume

    2009-01-01

    El interés de las ciencias aplicadas al deporte en los espectadores y el espectáculo deportivo ha sido más bien escaso y en muchos casos sobrecentrado en la violencia. El objetivo de este trabajo es proponer una clasificación alternativa de los aficionados al fútbol a partir del tipo de contacto que tienen con el espectáculo y describir sus valores, motivaciones y compromiso. Mil setecientas diecinueve personas asistentes a partidos de fútbol organizados por la Liga de...

  13. Entusiastas, aficionados y espectadores: sus valores, motivaciones y compromiso

    OpenAIRE

    Miquel Torregrosa; Jaume Cruz

    2009-01-01

    El interés de las ciencias aplicadas al deporte en los espectadores y el espectáculo deportivo ha sido más bien escaso y en muchos casos sobrecentrado en la violencia. El objetivo de este trabajo es proponer una clasificación alternativa de los aficionados al fútbol a partir del tipo de contacto que tienen con el espectáculo y describir sus valores, motivaciones y compromiso. Mil setecientas diecinueve personas asistentes a partidos de fútbol organizados por la Liga de Fútbol Profesional con...

  14. Toxicity of herbal medicines with interest to SUS: a review

    Directory of Open Access Journals (Sweden)

    Ciciane Pereira Marten Fernandes

    2016-11-01

    Full Text Available Abstract: In Brazil, ever since colonization plants have been used as natural products; thus, the National Health Surveillance Agency has been establishing rules for herbal medicine regulation; in this light, 71 plant species were chosen and empirically used in the country to investigate their medicinal properties. Currently, 12 of these 71 plants have been approved to be used in SUS (Public Health System, the remaining species still need further research. Thusly, this review aimed to seek information from toxicological studies on the plants that have not yet been officially approved, to stimulate new research in the field, promoting an economical and functional impact. In order to obtain the information, the keywords plant name + toxicity and/or toxicological studies were searched in the most prominent databases, both in English and in Portuguese. The ten plants with the most references were included in this review. Among the ten plants assessed, three have all the required studies required by the National Health Surveillance Agency, two of which we recommend the immediate adoption by SUS. In general, three plants have a determined LD50, nine have reproductive toxicity data, and five have not yet shown any sign of toxicity.

  15. Entusiastas, aficionados y espectadores: sus valores, motivaciones y compromiso

    Directory of Open Access Journals (Sweden)

    Miquel Torregrosa

    2009-01-01

    Full Text Available El interés de las ciencias aplicadas al deporte en los espectadores y el espectáculo deportivo ha sido más bien escaso y en muchos casos sobrecentrado en la violencia. El objetivo de este trabajo es proponer una clasificación alternativa de los aficionados al fútbol a partir del tipo de contacto que tienen con el espectáculo y describir sus valores, motivaciones y compromiso. Mil setecientas diecinueve personas asistentes a partidos de fútbol organizados por la Liga de Fútbol Profesional contestaron cuestionarios sobre sus valores, motivaciones y relación con el fútbol. Los resultados muestranque los entusiastas son los aficionados más motivados y comprometidos con el fútbol al mismo tiempo que participan significativamente más de valores relacionados con el conservadurismo y la autopromoción que las otras tres categorías (espectadores, aficionados presenciales y aficionados virtuales. La clasificaciónpropuesta en base al tipo de contacto con el fútbol permite conceptualizar el fútbol como algo más que lo que ocurre en los estadios y abre las puertas a intervencionesdesde lo positivo para promover el fair play y la deportividad en los aficionados.

  16. Cicatrici: El secreto de sus ojos di Sacheri e Campanella

    Directory of Open Access Journals (Sweden)

    Sandro Volpe

    2012-11-01

    Full Text Available In 2005 the Argentinian writer Eduardo Sacheri published The Question in Their Eyes (La pregunta de sus ojos.  The novel narrates on a double level, both fictional and temporal, the decision of a retired prosecutor to come to terms with a case of rape and murder which had taken place years earlier: his life had been shattered by the consequences of that tragedy, and writing about it would be a way to start living again.  The director Juan José Campanella - widely famous for having directed episodes of the television series Law & Order, but especially as the director of successful films such as El hijo de la novia - decided to adapt the novel and involved Sacheri in the project: the close collaboration between writer and director produced a bold screenplay that adds to the noir thriller a more romantic dimension.  Disproving the commonplace of the writer jealous of his work, they wrote together a new version which retains certain elements of the original text, but also introduces a number of relevant changes to the structure, characters and ending of the novel.  The Secret in Their Eyes  (El secreto de sus ojos, shot in 2008, was released the following year and in 2010 won the Academy Award for best foreign language film.

  17. PENGEMBANGAN MODEL PEMBELAJARAN BERBASIS MASALAH YANG BERMUATAN NILAI-NILAI PENDIDIKAN KARAKTER DALAM PEMBELAJARAN MENULIS CERPEN PADA KELAS VIII SMP

    Directory of Open Access Journals (Sweden)

    Aditya Dwi Haryawan

    2014-08-01

    Full Text Available Menulis merupakan suatu keterampilan yang harus dimiliki peserta didik sekolah menengah pertama. Melaluitulisan, peserta didik dapat menyampaikan pengalaman, pikiran, perasaan, atau keinginan. Masalah penelitianini adalah (1 bagaimanakah kebutuhan pengembangan model pembelajaran berbasis masalah yang bermuatannilai-nilai pendidikan karakter dalam pembelajaran menulis cerpen berdasarkan persepsi guru dan pesertadidik kelas VIII SMP?; (2 bagaimanakah prinsip-prinsip pengembangan model pembelajaran berbasis masalahyang bermuatan nilai-nilai pendidikan karakter dalam pembelajaran menulis cerpen pada peserta didik kelasVIII SMP? (3 bagaimanakah pengembangan prototipe model pembelajaran berbasis masalah yang bermuatannilai-nilai pendidikan karakter dalam pembelajaran menulis cerpen pada kelas VIII SMP?; (4 bagaimanakahkeberterimaan penerapan pengembangan model pembelajaran berbasis masalah yang bermuatan nilai-nilaipendidikan karakter dalam pembelajaran menulis cerpen pada kelas VIII SMP. Dalam penelitian ini digunakandesain Research and Development. Tahapan yang dilakukan dalam penelitian ini adalah studi pustaka, analisiskebutuhan, pengembangan model yang dikembangkan, uji validasi, revisi, implementasi, revisi akhir,pengembangan model/produk akhir. Pengumpulan data dilakukan dengan observasi, angket, wawancara, tes,dan dokumentasi foto. Writing is a skill that must be owned by middle school students. Through writing, students canconvey experiences, thoughts, feelings, or desires. The research problem is (1 How can the needsof the development of PBL model that charged the values of character education in learning towrite short stories on the perceptions of teachers and students of class VIII?; (2 How do thecharacteristics of the development of PBL model value-laden -the value of character education inlearning to write short stories at the high school of learner assessment system class?; (3 How isthe development of a prototype model of PBL  charged

  18. Tecniche costruttive e forme di potere nella Toscana sud-occidentale (secc. VIII-XIV

    Directory of Open Access Journals (Sweden)

    Bianchi, Giovanna

    2005-12-01

    Full Text Available This paper tells about the analysis of the building techniques of elevations inferred from data obtained in extensive projects of archaeological research executed in western Tuscany's rural field from half '90s of last century to present. The text looks over the changes from wooden building trade related to the first high rise habitants in VIIth-VIIIth century, until the pattern settlements in the second half of VIIIth and XIth centuries, characterized by the first use of masonry and the presence of expert master builders. The more complex organization of the building workshops for castles of the XIth and XIIth centuries in relation with the liege lord's rising politic abusive authority is explained in the following part. The subsequent formation of new suburbs between the XIIIth and the XIV centuries is characterized by a different way of use of building techniques, often founded over pre-existing castles, linked to local council, up to the political and economical influence of Pisa in this territory.Nell’articolo si tratta l’analisi delle tecniche murarie desunta da dati provenienti da ampi progetti di indagine archeologica svolti in ambito rurale nella Toscana occidentale dalla metà degli anni Novanta dello scorso secolo ad oggi. Nel testo si esaminano i cambiamenti dei modi di edificare a partire dall’edilizia in legno dei primi abitati di altura di VII-VIII secolo, sino agli insediamenti più strutturati di seconda metà VIII e IX secolo, caratterizzati da un primo uso della pietra e dalla presenza di maestranze specializzate. In seguito si analizza la più complessa organizzazione del cantiere propria della costruzione dei castelli di XI e XII secolo in rapporto ai poteri politici ed economici delle nascenti signorie territoriali. Un differente uso delle tecniche costruttive caratterizza la successiva formazione di nuovi borghi tra XIII e XIV secolo, spesso impiantati sui preesistenti castelli, legati ai locali organismi comunali

  19. Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms.

    Science.gov (United States)

    Albánez, S; Ogiwara, K; Michels, A; Hopman, W; Grabell, J; James, P; Lillicrap, D

    2016-05-01

    Essentials von Willebrand factor (VWF) and factor VIII (FVIII) levels are modulated by age and ABO status. The effect of aging and ABO blood type on VWF and FVIII was assessed in 207 normal individuals. Aging and ABO blood type showed combined and bidirectional influences on VWF and FVIII levels. Aging and ABO blood type influence VWF levels through both secretion and clearance mechanisms. Background The effect of aging and ABO blood type on plasma levels of von Willebrand factor (VWF) and factor VIII (FVIII) have been widely reported; however, a comprehensive analysis of their combined effect has not been performed and the mechanisms responsible for the age-related changes have not been determined. Objectives To assess the influence of aging and ABO blood type on VWF and FVIII levels, and to evaluate the contribution of VWF secretion and clearance to the age-related changes. Methods A cross-sectional observational study was performed in a cohort of 207 normal individuals, whose levels of VWF, FVIII, VWF propeptide (VWFpp), VWFpp/VWF:Ag ratio and blood type A antigen content on VWF (A-VWF) were quantified. Results Aging and ABO blood type exerted interrelated effects on VWF and FVIII plasma levels, because the age-related increase in both proteins was significantly higher in type non-O individuals (β = 0.011 vs. 0.005). This increase with age in non-O subjects drove the differences between blood types in VWF levels, as the mean difference increased from 0.13 U/mL in the young to 0.57 U/mL in the old. Moreover, A-VWF was associated with both VWF antigen (β = 0.29; 95% confidence interval [CI], 0.09, 0.50) and VWF clearance (β = -0.15; 95% CI, -0.25, -0.06). We also documented an effect of ABO blood type on VWF secretion with aging, as old individuals with blood type non-O showed higher levels of VWFpp (mean difference 0.29 U/mL). Conclusions Aging and ABO blood type have an interrelated effect on VWF and FVIII levels, where the effect of one is significantly

  20. Penggunaan Media Software GeoGebra untuk Meningkatkan Kemampuan Representasi Matematis Siswa SMP Kelas VIII

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    Marini Oktaria

    2016-06-01

    Full Text Available Rendahnya kemampuan representasi matematis siswa menjadi salah satu penyebab rendahnya prestasi belajar matematika siswa. Hal ini diperkuat dengan hasil laporan TIMSS dan PISA yang menunjukkan rendahnya kemampuan matematika siswa Indonesia. Untuk membantu siswa meningkatkan kemampuan representasi matematis digunakan suatu media pembelajaran matematika. Salah satu media pembelajaran matematika yang dapat merepresentasikan model matematika adalah software GeoGebra. Maka dari itu, penelitian ini bertujuan untuk mengetahui apakah software GeoGebra dapat meningkatkan kemampuan representasi matematis siswa pada materi SPLDV. Sampel dalam penelitian ini adalah siswa kelas VIII.2 SMP Islamic Village tahun ajaran 2015/2016 semester II sebanyak 29 orang dengan purposive sampling. Instrumen penelitian berupa tes uraian untuk mengukur kemaampuan representasi matematis. Metode dalam penelitian ini adalah metode kuantitatif jenis pra eksperimen dengan one group pretest-posttest design. Analisis data penelitian ini menggunakan uji non-parametrik Wilcoxon Signed Ranks Test. Hasil penelitian menunjukkan bahwa penggunaan media software GeoGebra dapat meningkatkan kemampuan representasi matematis siswa pada materi sistem persamaan linier dua variabel (SPLDV. Peningkatan yang diperoleh berada pada kategori sedang sebesar 0,651.Low ability students 'mathematical representation became one of the causes of low achievement of students' mathematics learning. This was reinforced by the results of the TIMSS and PISA report which indicates a low ability students' mathematical Indonesia. To help students improve mathematical representation, it needs to use a medium of learning mathematics. One math learning media that can represent mathematical models were software GeoGebra. Therefore, this study aims to determine whether the software GeoGebra can improve students' mathematical representation at SPLDV material. The sample in this study were students VIII.2 SMP Islamic

  1. Potential role of a new PEGylated recombinant factor VIII for hemophilia A

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    Wynn TT

    2016-06-01

    Full Text Available Tung Thanh Wynn,1 Burak Gumuscu,2,3 1Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Florida, Gainesville, FL, 2Pediatric Hematology-Oncology, Bon Secours Health System, St. Mary’s Hospital, Richmond, VA, 3Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Virginia, Charlottesville, VA, USA Abstract: Hemophilia A, a deficiency in the activity of coagulation factor (F VIII, is an X-linked bleeding disorder with an approximate incidence of one in 5,000 male infants. Bleeding-related complications often result in greater severity of disease, poor quality of life, surgical interventions for severe joint destruction, and shortened life span. With the availability of plasma-derived and recombinant FVIII products, the benefits of primary prophylaxis were demonstrated and is now the standard of care for patients with severe factor deficiencies. Current hemophilia research is focusing on the creation of new factor replacement therapies with longer half-lives; accessing alternative mechanisms to achieve desired hemostasis and enhance bypassing ­activity; and limiting the immunogenicity of the protein. PEGylation involves the covalent attachment of polyethylene glycol (PEG to a protein, peptide, or a small molecule drug. PEG effectively increases the molecular weight and size of the protein by creating a hydrophilic cloud around the molecule. This molecular change may reduce susceptibility of the molecule to proteolytic activity and degradation. It is also believed that PEGylation changes the surface charge of the protein that ultimately interferes with some receptor-mediated clearance processes. The half-life of PEGylated factor is more prolonged when compared to non-PEGylated full-length recombinant FVIII. The dawn of a new era in the care of hemophilia patients is upon us with the release of recombinant FVIII products with extended half-lives, and products with even more extended half

  2. PENGARUH KEMANDIRIAN BELAJAR DAN PENGGUNAAN UANG SAKU TERHADAP PRESTASI BELAJAR KOMPETENSI DASAR EKONOMI KELAS VII DAN VIII

    Directory of Open Access Journals (Sweden)

    Apri Dwi Astuti

    2012-10-01

    Full Text Available Kemandirian belajar membantu siswa untuk bertanggung jawab dan menumbuhkan kesadaran belajar. Penggunaan uang saku menumbuhkan jiwa mandiri, jujur dan komitmen. Adapun hasil observasi awal menunjukkan masih ada siswa kels VII dan VIII SMP Semesta untuk kompetensi dasar ekonomi dibawah KKM. Tujuan penelitian ini untuk mengetahui pengaruh kemandirian belajar dn penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta. Populasi penelitian ini adalah semua siswa kelas VII dan VIII SMP Semesta Boarding School Semarang. Variabel penelitian ini adalah kemandirian belajar dan penggunaan uang saku sebagai variabel bebas, sedangkan untuk� variabel terikat adalah prestasi belajar kompetensi dasar ekonomi. Data diambil dengan metode wawancara, kuesioner dan dokumentasi guru. Analisis data menggunakan analisis regresi linear berganda.Berdasarkan penelitian secara simultan menunjukkan adanya pengaruh antara kemandirian belajar dan penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 51,3%. Secara parsial, pengaruh kemandirian belajar terhadap prestasi belajar kompetensi dasar ekonomi sebesar 66,2% dan pengaruh penggunaan uang saku terhadap prestasi belajar kompetensi dasar ekonomi sebesar 62,5%.Berdasarkan hasil penelitian diatas disimpulkan bahwa kemandirian belajar dan penggunaan uang saku berpengaruh positif baik secara simultan maupun parsial terhadap prestasi belajar kompetensi dasar ekonomi kelas VII dan VIII SMP Semesta Boarding school semarang tahun pelajaran 2011/2012. Saran yang berkaitan dengan penelitian ini yaitu : 1 Sekolah disarankan untuk memberikan batasan siswa pulang ke rumah agar dapat membantu siswa beradaptasi dengan cepat dan mudah tinggal di asrama. 2 Orang tua disarankan untuk memberikan uang saku yang disesuaikan dengan kebutuhan siswa. 3 Siswa disarankan untuk meningkatkan kemandirian dalam aspek belajar terutama bagi mata pelajaran yang masih kurang dari

  3. Comparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells.

    Science.gov (United States)

    Peyron, Ivan; Hartholt, Robin B; Pedró-Cos, Laura; van Alphen, Floris; Brinke, Anja Ten; Lardy, Neubury; Meijer, Alexander B; Voorberg, Jan

    2018-01-01

    The development of anti-factor VIII antibodies is a major complication of the treatment of patients with hemophilia A. Generation of high affinity anti-factor VIII antibodies is dependent on help provided by CD4 + T cells that recognize factor VIII-derived peptides presented on class II major histocompatibility complex on the surface of antigen-presenting cells. In order to identify the immune-dominant epitopes that can be presented to CD4 + T cells, we previously developed a mass spectrometry-based method to identify factor VIII-derived peptides that are presented on human leukocyte antigen (HLA)-DR. In the present work, we compared the repertoire of FVIII-derived peptide presented on HLA-DR and HLA-DQ. Monocyte-derived dendritic cells from nine HLA-typed healthy donors were pulsed with recombinant factor VIII. HLA-DR and HLA-DQ molecules were purified using monoclonal antibodies. Our data show that HLA-DQ and HLA-DR present a similar repertoire of factor VIII-derived peptides. However, the number of peptides associated with HLA-DQ was lower than that with HLA-DR. We also identified a peptide, within the acidic a3 domains of factor VIII, which is presented with higher frequency on HLA-DQ. Interestingly, this peptide was found to have a higher predicted affinity for HLA-DQ than for HLA-DR. Taken together, our data suggest that HLA-DQ participates in the presentation of factor VIII peptides, thereby contributing to the development of inhibitory antibodies in a proportion of patients with severe hemophilia A. Copyright© 2018 Ferrata Storti Foundation.

  4. Efficacy and safety of rVIII-SingleChain: results of a phase 1/3 multicenter clinical trial in severe hemophilia A

    Science.gov (United States)

    Mahlangu, Johnny; Kuliczkowski, Kazimierz; Karim, Faraizah Abdul; Stasyshyn, Oleksandra; Kosinova, Marina V.; Lepatan, Lynda Mae; Skotnicki, Aleksander; Boggio, Lisa N.; Klamroth, Robert; Oldenburg, Johannes; Hellmann, Andrzej; Santagostino, Elena; Baker, Ross I.; Fischer, Kathelijn; Gill, Joan C.; P’Ng, Stephanie; Chowdary, Pratima; Escobar, Miguel A.; Khayat, Claudia Djambas; Rusen, Luminita; Bensen-Kennedy, Debra; Blackman, Nicole; Limsakun, Tharin; Veldman, Alex; St. Ledger, Katie

    2016-01-01

    Recombinant VIII (rVIII)-SingleChain is a novel B-domain–truncated recombinant factor VIII (rFVIII), comprised of covalently bonded factor VIII (FVIII) heavy and light chains. It was designed to have a higher binding affinity for von Willebrand factor (VWF). This phase 1/3 study investigated the efficacy and safety of rVIII-SingleChain in the treatment of bleeding episodes, routine prophylaxis, and surgical prophylaxis. Participants were ≥12 years of age, with severe hemophilia A (endogenous FVIII <1%). The participants were allocated by the investigator to receive rVIII-SingleChain in either an on-demand or prophylaxis regimen. Of the 175 patients meeting study eligibility criteria, 173 were treated with rVIII-SingleChain, prophylactically (N = 146) or on-demand (N = 27). The total cumulative exposure was 14 306 exposure days (EDs), with 120 participants reaching ≥50 EDs and 52 participants having ≥100 EDs. Hemostatic efficacy was rated by the investigator as excellent or good in 93.8% of the 835 bleeds treated and assessed. Across all prophylaxis regimens, the median annualized spontaneous bleeding rate was 0.00 (Q1, Q3: 0.0, 2.4) and the median overall annualized bleeding rate (ABR) was 1.14 (Q1, Q3: 0.0, 4.2). Surgical hemostasis was rated as excellent/good in 100% of major surgeries by the investigator. No participant developed FVIII inhibitors. In conclusion, rVIII-SingleChain is a novel rFVIII molecule showing excellent hemostatic efficacy in surgery and in the control of bleeding events, low ABR in patients on prophylaxis, and a favorable safety profile in this large clinical study. This trial was registered at www.clinicaltrials.gov as #NCT01486927. PMID:27330001

  5. Influence Model Assisted Learning Cycle Mind Map to Achievement Physics Laboratory Judging from the performance Grade VIII SMPN 1 Rejoso Pasuruan

    OpenAIRE

    Ary Analisa Rahma

    2014-01-01

    Pengaruh Model Siklus Belajar Berbantuan Mind Map terhadap Prestasi Belajar Fisika Ditinjau dari Kinerja Laboratorium Siswa Kelas VIII SMPN 1 Rejoso Kabupaten Pasuruan Abstract: This study aimed to examine the effect of the learning cycle models aided the mind map on the learning achievement in terms of the performance of laboratory physics class VIII student on light material in SMP Negeri 1 Rejoso Pasuruan. This study is a quasi-experimental research. The research design used is a 2 x 2...

  6. Penggunaan Media Presentase Microsoft Power Point Untuk Meningkatkan Hasil Belajar IPS Terpadu Pada Siswa Kelas VIII a SMP Negeri 2 Tanantovea

    OpenAIRE

    Hitler, Ahmad

    2014-01-01

    Permasalahan yang diangkat dalam penelitian adalah apakah dengan penggunaan media Presentase Microsoft Power Point pada mata pembelajaran IPS Terpadu dapat meningkatkan hasil belajar siswa kelas VIII A di SMP Negeri 2 Tanantovea. Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa pada pokok bahasan Kolonialisme dan Imperialisme Barat di kelas VIII A SMP Negeri 2 Tanantovea. Penelitian ini dilakukan dalam 2 siklus, setiap siklus terdiri dari perencanaan, pelaksanaan tindakan, obs...

  7. MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR MATERI KURVA PERMINTAAN DAN KURVA PENAWARAN DENGAN PEMBELAJARAN SCAFFOLDING PADA KELAS VIII MTS MUHAMMADIYAH KAJEN

    Directory of Open Access Journals (Sweden)

    M Yusuf Supriyadi

    2013-11-01

    Full Text Available Penelitian ini merupakan penelitian tindakan kelas dengan tujuan untuk mengetahui ada tidaknya peningkatan aktivitas dan hasil belajar siswa setelah metode pembelajaran Scaffolding diterapkan pada materi kurva permintaan dan kurva penawaran kelas VIII A MTs. Muhammadiyah Kajen. Penelitian dilaksanakan dalam 2 siklus. Setiap siklus meliputi perencanaan, pelaksanaan, observasi, dan refleksi. Subjek penelitian ini adalah siswa kelas VIII E MTs. Muhammadiyah Kajen Tahun Ajaran 2013/2014. Sementara faktor yang diteliti di antaranya adalah aktivitas siswa, aktivitas guru, dan hasil belajar siswa. Tujuan penelitian ini adalah. Hasil penelitian siklus I dan siklus II menunjukkan peningkatan aktivitas siswa dan aktivitas guru. Rata-rata hasil belajar dan ketuntasan klasikal juga mengalami peningkatan. Hasil penelitian dapat disimpulkan bahwa pembelajaran Scaffolding dapat meningkatan aktivitas dan hasil belajar. Saran dari hasil penelitian ini adalah: Guru dapat menerapkan pembelajaran Scaffolding pada materi kurva permintaan dan kurva penawaran. Guru harus mempersiapkan pembelajaran dengan baik agar proses pembelajaran berlangsung dengan sesuai rencana. This research is a classroom action research which aims to determine whether there is an increase in activity and student achievement after Scaffolding learning applied to the lesson ofdemand and supply curve in class VIII A MTs. Muhammadiyah Kajen.. This research conducted in two cycles. Each cycle includes planning, implementation, observation, and reflection. The subjects of this Research were students of class VIII E MTs. Muhammadiyah Kajen Academic Year 2013/2014. The factors studied include student activities, teacher activities, and student learning outcomes. The results in the first and second cycle showed increased student and teacher activity. Average classical completeness of learning outcome is also increased. The research can be concluded that Scaffolding Learning can be increase learning

  8. Neurotology findings in patients with diagnosis of vascular loop of cranial nerves VIII in magnetic resonance imaging

    Directory of Open Access Journals (Sweden)

    Grocoske, Francisco Luiz Busato

    Full Text Available Introduction: The vascular compression by redundant vessels under the VIII cranial nerves has been studied since the 80's, and many authors proposed correlations between the compression and the otoneurological findings (vertigo, tinnitus, hypoacusis, audiometry and electrophysiological findings. Objective: Analyze and correlate the different signs and otoneurological symptoms, the audiological findings and its incidence over individuals with Vascular Loop (VL diagnosis of VIII cranial nerves by magnetic resonance imaging (MRI. Method: Retrospective study through the analysis of medical records of 47 patients attended in the otoneurology clinic of Clinical Hospital of UFPR. All the patients have MRI exams with compatible pictures of VL of the VIII cranial nerves. Results: The tinnitus was the most frequent symptom, in 83% of the patients, followed by hypoacusis (60% and vertigo (36%. The audiometry presented alterations in 89%, the brainstem evoked auditory potential in 33% and the vecto-electronystagmography in 17% of the patients. Was not found statistically significant relation between the buzz or hypoacusis, and the presence of VL in MRI. Only 36% of patients had complaints of vertigo, the main symptom described in theory of vascular compression of the VIII pair of nerve. As in the audiometry and in brainstem evoked auditory potential was not found a statistically significant relation between the exam and the presence of the VL in the RMI. Conclusion: The results show independence between the findings of the RMI, clinical picture and audiological results (p>0,05 suggesting that there are no exclusive and direct relation between the diagnosis of vascular loop in the MRI and the clinical picture matching.

  9. The Funnel Geometry of Open Flux Tubes in the Low Solar Corona Constrained by O VI and Ne VIII Outflow

    Science.gov (United States)

    Byhring, Hanne S.; Esser, Ruth; Lie-Svendsen, Oystein

    2008-01-01

    Model calculations show that observed outflow velocities of order 7-10 km/s of C IV and O VI ions, and 15-20 km/s of Ne VIII ions, are not only consistent with models of the solar wind from coronas holes, but also place unique constraints on the degree of flow tube expansion as well as the location of the expansion in the transition region/lower corona.

  10. Development of Integrated Natural Science Teaching Materials Webbed Type with Applying Discourse Analysis on Students Grade VIII in Physics Class

    Science.gov (United States)

    Sukariasih, Luh

    2017-05-01

    This study aims to produce teaching materials integrated natural science (IPA) webbed type of handout types are eligible for use in integrated science teaching. This type of research IS a kind of research and development / Research and Development (R & D) with reference to the 4D development model that is (define, design, develop, and disseminate). Data analysis techniques used to process data from the results of the assessment by the validator expert, and the results of the assessment by teachers and learners while testing is limited (12 students of class VIII SMPN 10 Kendari) using quantitative descriptive data analysis techniques disclosed in the distribution of scores on the scale of five categories grading scale that has been determined. The results of due diligence material gain votes validator material in the category of “very good” and “good”, of the data generated in the feasibility test presentation obtained the category of “good” and “excellent”, from the data generated in the feasibility of graphic test obtained the category of “very good “and” good “, as well as of the data generated in the test the feasibility of using words and language obtained the category of“very good “and” good “, so with qualifications gained the teaching materials IPA integrated type webbed by applying discourse analysis on the theme of energy and food for Junior High School (SMP) grade VIII suitable as teaching materials. In limited testing, data generated in response to a science teacher at SMPN 10 Kendari to product instructional materials as “excellent”, and from the data generated while testing is limited by the 12 students of class VIII SMPN 10 Kendari are more students who score indicates category “very good”, so that the qualification obtained by the natural science (IPA) teaching material integrated type webbed by applying discourse analysis on the theme of energy and food for SMP / class VIII fit for use as teaching material.

  11. La etnobotánica: su alcance y sus objetos

    Directory of Open Access Journals (Sweden)

    Schultes Richard Evans

    1941-11-01

    Full Text Available Existe entre la Botánica y la Antropología una ciencia intermedia a la que, desde hace medio siglo, se ha dado el nombre de Etnobotánica. Como ocurre con otras ciencias interfacultativas o interdisciplinales la Etnobotánica no se puede definir fácilmente y por esto ha habido muchas diferencias de opinión en cuanto a su alcance y sus objetos. En su más amplio sentido, la Etnobotánica es el estudio de las relaciones que existen entre el hombre y su ambiente vegetal, es decir las plantas que lo rodean. En un sentido más restringido, se ha considerado solamente como el estudio del uso de las plantas cultivadas y silvestres por los pueblos primitivos, usualmente los aborígenes.

  12. Estudio de las propiedades del grafeno y sus posibilidades

    OpenAIRE

    Valverde Guijarro, Ángel Luis

    2014-01-01

    El objetivo principal de este proyecto es el de estudiar mediante elipsometría las propiedades ópticas de una capa de grafeno sobre varios sustratos, y cómo ésta puede alterar los parámetros ópticos del material sobre el que reposa. Partiendo de muestras de cobre y silicio, se estudiará cómo pueden ser modificadas sus propiedades con tan sólo depositar sobre ellas una capa de grafeno cuyo espesor es el de un átomo. Se usará un elipsómetro de alta precisión proporcionado por el INTA para anal...

  13. Diferença de Classe no SUS é inconstitucional!

    Directory of Open Access Journals (Sweden)

    Alethele de Oliveira Santos

    2015-12-01

    Full Text Available A discussão sobre a ‘diferença de classe’ decorre do Recurso Extraordinário (RE 581488 interposto pelo Conselho Regional de Medicina do Rio Grande do Sul (Cremers em face da decisão do Tribunal Regional Federal da 4ªRegião (TRF –4ª, em favor do município de Canela (RS (1 junto ao Supremo Tribunal Federal (STF, com repercussão geral  reconhecida sob o número 579. Trata-se da possibilidade de que paciente do Sistema Único de Saúde (SUS pague valor financeiro por hotelaria diferenciada, ou ainda, médico de sua preferência.

  14. The role of dentists in the Unified Health System (SUS)

    OpenAIRE

    Aerts, Denise; Abegg, Claídes; Cesa, Kátia

    2004-01-01

    O Sistema Único de Saúde é um processo social em construção permanente, sendo fundamental a contínua discussão sobre seu modelo de atenção, os paradigmas explicativos do processo saúde-doença que o embasam e o papel de diferentes profissionais que nele atuam. Esse trabalho objetiva a discussão sobre a atuação do cirurgião-dentista no SUS. Uma forma de sistematizar suas possibilidades de atuação é a sua inserção no sistema. Em nível central ou distrital, deve atuar em equipes interdisciplinare...

  15. Migrantes culiacanenses en California: Diversidad en sus redes migratorias

    Directory of Open Access Journals (Sweden)

    Ernesto SÁNCHEZ SÁNCHEZ

    2012-01-01

    Full Text Available Es un hecho la dinámica extraordinaria que tienen los lugares de reciente migración, ya sea como lugares de origen o destino. El estado de Sinaloa se suma a esta dinámica en la cual aparecen ahora sus tres principales zonas urbanas --Culiacán, Mazatlán y Ahome-- dentro de su mapa migratorio. Sin embargo la migración, como proceso social, implica una serie de interrelaciones formadas tiempo atrás. Éstas repercuten en la conformación de las nuevas redes migratorias. No obstante, durante décadas, las principales zonas de expulsión en Sinaloa han sido rurales y siguen teniendo un papel esencial en las actuales relaciones sociales de los migrantes provenientes de Culiacán.

  16. FEAP-SUS: integration of sustainability in design tool

    Directory of Open Access Journals (Sweden)

    Paulo Cesar Machado Ferroli

    2011-05-01

    Full Text Available Industrial Design is an activity that requires creativity, sense of management, great capacity of synthesis and much knowledge in the design area. Considering by virtue of the expressive volume of data and information, the designer uses methodologies, tools and techniques project that help this activity. These fools needs priors relevant factors, without neglecting any of them. This demands an interdisciplinary attitude towards the essence, involving several areas of knowledge and forcing the designer to a good management capacity of information (design management. Adding to this matter is also the inclusion of sustainability, and the aspects that constitute it: economic sustainability, social and environmental. So, this work presents the development of the FEAP – SUS tool. The Study Case was applied in Project Graduation from the Industrial Design Course at the UNIVALI.

  17. Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research

    DEFF Research Database (Denmark)

    Kornum, Birgitte R; Knudsen, Gitte M

    2011-01-01

    of farm animal welfare researchers, but it has only recently received interest in the wider neuroscience community. Several behavioral tasks have successfully been adapted to the pig, and valuable results have been produced. However, most tasks have only been established at a single research facility......Within neuroscience and biobehavioral research, the pig (Sus scrofus) is increasingly being acknowledged as a valuable large animal species. Compared to the rodent brain, the pig brain more closely resembles the human brain in terms of both anatomy and biochemistry, which associates the pig...... with a higher translational value. Several brain disorders have been fully or partially modeled in the pig and this has further spurred an interest in having access to behavioral tasks for pigs, and in particular to cognitive tasks. Cognitive testing of pigs has been conducted for several years by a small group...

  18. Structural Classification of Wild Boar (Sus scrofa) Vocalizations.

    Science.gov (United States)

    Garcia, Maxime; Gingras, Bruno; Bowling, Daniel L; Herbst, Christian T; Boeckle, Markus; Locatelli, Yann; Fitch, W Tecumseh

    2016-04-01

    Determining whether a species' vocal communication system is graded or discrete requires definition of its vocal repertoire. In this context, research on domestic pig ( Sus scrofa domesticus ) vocalizations, for example, has led to significant advances in our understanding of communicative functions. Despite their close relation to domestic pigs, little is known about wild boar ( Sus scrofa) vocalizations. The few existing studies, conducted in the 1970s, relied on visual inspections of spectrograms to quantify acoustic parameters and lacked statistical analysis. Here, we use objective signal processing techniques and advanced statistical approaches to classify 616 calls recorded from semi-free ranging animals. Based on four spectral and temporal acoustic parameters-quartile Q25, duration, spectral flux, and spectral flatness-extracted from a multivariate analysis, we refine and extend the conclusions drawn from previous work and present a statistically validated classification of the wild boar vocal repertoire into four call types: grunts, grunt-squeals, squeals, and trumpets. While the majority of calls could be sorted into these categories using objective criteria, we also found evidence supporting a graded interpretation of some wild boar vocalizations as acoustically continuous, with the extremes representing discrete call types. The use of objective criteria based on modern techniques and statistics in respect to acoustic continuity advances our understanding of vocal variation. Integrating our findings with recent studies on domestic pig vocal behavior and emotions, we emphasize the importance of grunt-squeals for acoustic approaches to animal welfare and underline the need of further research investigating the role of domestication on animal vocal communication.

  19. Sindicalismo, SUS e planos de saúde

    Directory of Open Access Journals (Sweden)

    José Augusto Pina

    Full Text Available Este artigo discute a interlocução do sindicalismo brasileiro com o Sistema Único de Saúde (SUS e os planos e seguros privados de saúde. São ponderadas algumas teses na Saúde Coletiva à luz de estudos mais recentes nas Ciências Sociais sobre o sindicalismo e realizada análise documental para o caso da Central Única dos Trabalhadores (CUT, tomado aqui como referência. Aponta-se a necessidade de considerar os pesos relativos que a ação sindical atribuiu a cada um dos aspectos da relação, SUS e planos privados de saúde, pelas distintas conjunturas do país. O conflito entre trabalhadores e empresas somado ao desemprego e à precarização do trabalho expõe os limites das coberturas assistenciais privadas e impele a representação sindical a pleitear a intervenção estatal. O trabalho refletiu sobre as distintas modalidades de ação sindical na empresa e no Estado. A complexidade dessa dinâmica fez emergir um setor sindical interessado na gestão da previdência complementar e dos planos de saúde e, ao mesmo tempo, recria as circunstâncias e traz novas possibilidades de as organizações sindicais se colocarem na cena política e aglutinar os interesses de amplos segmentos dos trabalhadores para pressionar o Estado na defesa da melhoria do sistema público de saúde.

  20. PENGEMBANGAN KARAKTER KEDISIPLINAN DAN KEMAMPUAN PEMECAHAN MASALAH MELALUI MODEL LAPS-HEURISTIK MATERI LINGKARAN KELAS-VIII

    Directory of Open Access Journals (Sweden)

    Sri Wahyuni

    2015-08-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui (1 apakah pembelajaran dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat mengembangkan karakter kedisiplinan peserta didik, (2 apakah pembelajaran dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat meningkatkan kemampuan pemecahan masalah peserta didik, (3 apakah kemampuan pemecahan masalah matematika peserta didik yang diajar dengan model pembelajaran LAPS-Heuristik pada materi lingkaran kelas-VIII dapat mencapai kriteria ketuntasan minimal yang ditentukan. Desain penelitian ini adalah kualitatif deskriptif, artinya menggambarkan atau mendeskripsikan kejadian-kejadian yang menjadi pusat perhatian secara kualitatif dan berdasar data kualitatif. Penentuan sumber data dalam penelitian ini menggunakan teknik purposive sampling, yaitu dipilih dengan pertimbangan dan tujuan tertentu. Data diperoleh dengan observasi, wawancara, dan tes yang kemudian dianalisis menggunakan analisis kualitatif dan analisis gain untuk mengukur peningkatan. Analisis kualitatif menunjukkan karakter kedisiplinan dan kemampuan pemecahan masalah peserta didik meningkat, serta kemampuan pemecahan masalah peserta didik mencapai KKM melalui model pembelajaran LAPS-Heuristik.

  1. Partial correction of a severe molecular defect in hemophilia A, because of errors during expression of the factor VIII gene

    Energy Technology Data Exchange (ETDEWEB)

    Young, M.; Antonarakis, S.E. [Univ. of Geneva (Switzerland); Inaba, Hiroshi [Tokyo Medical College (Japan)] [and others

    1997-03-01

    Although the molecular defect in patients in a Japanese family with mild to moderately severe hemophilia A was a deletion of a single nucleotide T within an A{sub 8}TA{sub 2} sequence of exon 14 of the factor VIII gene, the severity of the clinical phenotype did not correspond to that expected of a frameshift mutation. A small amount of functional factor VIII protein was detected in the patient`s plasma. Analysis of DNA and RNA molecules from normal and affected individuals and in vitro transcription/translation suggested a partial correction of the molecular defect, because of the following: (i) DNA replication/RNA transcription errors resulting in restoration of the reading frame and/or (ii) {open_quotes}ribosomal frameshifting{close_quotes} resulting in the production of normal factor VIII polypeptide and, thus, in a milder than expected hemophilia A. All of these mechanisms probably were promoted by the longer run of adenines, A{sub 10} instead of A{sub 8}TA{sub 2}, after the delT. Errors in the complex steps of gene expression therefore may partially correct a severe frameshift defect and ameliorate an expected severe phenotype. 36 refs., 6 figs.

  2. Establishment of the 2nd Korean national biological reference standard for blood coagulation factor VIII:C concentrate.

    Science.gov (United States)

    Lee, Naery; Seo, Ji Suk; Kim, Jae Ok; Ban, Sang Ja

    2017-05-01

    Since the 1st Korean national biological reference standard for factor (F)VIII concentrate, established in 2001, has shown declining potency, we conducted this study to replace this standard with a 2nd Korean national biological reference standard for blood coagulation FVIII concentrate. The candidate materials for the 2nd standard were prepared in 8000 vials with 10 IU/ml of target potency, according to the approved manufacturing process of blood coagulation Factor VIII:C Monoclonal Antibody-purified, Freeze-dried Human Blood Coagulation Factor VIII:C. Potency was evaluated by one-stage clotting and chromogenic methods and the stability was confirmed to meet the specifications during a period of 73 months. Since the potencies obtained by the two methods differed significantly (P < 0.015), the values were determined separately according to the geometric means (8.9 and 7.4 IU/vial, respectively). The geometric coefficients of interlaboratory variability were 3.4% and 7.6% by the one-stage clotting and chromogenic assays, respectively. Copyright © 2017 International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.

  3. Oxidation of factor VIII increases its immunogenicity in mice with severe hemophilia A.

    Science.gov (United States)

    Peyron, Ivan; Dimitrov, Jordan D; Delignat, Sandrine; Gangadharan, Bagirath; Srivastava, Alok; Kaveri, Srinivas V; Lacroix-Desmazes, Sébastien

    2018-03-01

    The development of antibodies against therapeutic factor VIII (FVIII) represents the major complication of replacement therapy in patients with severe hemophilia A. Amongst the environmental risk factors that influence the anti-FVIII immune response, the presence of active bleeding or hemarthrosis has been evoked. Endothelium damage is typically associated with the release of oxidative compounds. Here, we addressed whether oxidation contributes to FVIII immunogenicity. The control with N-acetyl cysteine of the oxidative status in FVIII-deficient mice, a model of severe hemophilia A, reduced the immune response to exogenous FVIII. Ex vivo exposure of therapeutic FVIII to HOCl induced a mild oxidation of the molecule as evidenced by the loss of free amines and resulted in increased FVIII immunogenicity in vivo when compared to native FVIII. The increased immunogenicity of oxidized FVIII was not reverted by treatment of mice with N-acetyl cysteine, and did not implicate an increased maturation of professional antigen-presenting cells. Our data document that oxidation influences the immunogenicity of therapeutic FVIII. Copyright © 2018 Elsevier Inc. All rights reserved.

  4. Recombinant to modified factor VIII and factor IX - chromogenic and one-stage assays issues.

    Science.gov (United States)

    Kitchen, S; Kershaw, G; Tiefenbacher, S

    2016-07-01

    The recent development of modified recombinant factor VIII (FVIII) and factor IX (FIX) therapeutic products with extended half-lives will create challenges for the haemostasis laboratory in obtaining recovery estimates of these products in clinical samples using existing assays. The new long-acting therapeutic concentrates contain molecular modifications of Fc fusion, site-specific of polyethylene glycol or albumin fusion. The optimum methods for monitoring each new product will need to be assessed individually and laboratories should select an assay which gives similar results to the assay used to assign potency to the product in question. For some extended half-life FVIII and FIX products some one stage assays are entirely unsuitable for monitoring purposes. For most products and assay reagents studied so far, and reviewed in this manuscript, chromogenic FVIII or FIX assays can be safely used with conventional plasma standards. If one stage assays are used then they should be performed using carefully selected reagents/methods which have been shown to recover activity close to the labelled potency for the specific product being monitored. © 2016 John Wiley & Sons Ltd.

  5. IMPLEMENTASI PENDEKATAN KONFLIK KOGNITIF DALAM PEMBELAJARAN FISIKA UNTUK MENUMBUHKAN KEMAMPUAN BERPIKIR KRITIS SISWA SMP KELAS VIII

    Directory of Open Access Journals (Sweden)

    A. Setyowati

    2012-01-01

    Full Text Available Tujuan dari penelitian ini adalah untuk mengetahui pengaruh implementasi pendekatan konflik kognitif dalam pembelajaran fisikapokok bahasan tekanan pada siswa kelas VIII terhadap kemampuan berpikir kritis, pemahaman konsep dan hasil belajar kognitifsiswa. Penelitian ini merupakan penelitian eksperimen. Setelah dilakukan pengambilan sampel secara random sampling,diperoleh kelas VIIIB sebagai kelas eksperimen dan kelas VIIIC sebagai kelas kontrol. Dari analisis uji rata-rata dua pihak atau uji tdiperoleh harga t tabel < t hitung yang berarti bahwa terdapat perbedaan yang signifikan terhadap rata-rata kemampuan berpikir kritis,pemahaman konsep dan hasil belajar kognitif kedua kelompok. Kesimpulan dari penelitian ini adalah implementasi pendekatankonflik kognitif pada pokok bahasan tekanan efektif digunakan dalam menumbuhkan kemampuan berpikir kritis, pemahamankonsep dan hasil belajar kognitif siswa kelas VIIISMP. This experiment research aims to examine the influence of cognitive conflict approach application to physics lesson with pressuretopic on critical thinking ability, concept understanding and cognitive learning achievement of the student. The random samplingused resulted class VIIIC as control group and VIIIB as experiment group. The t-test was performed to analyse the average ofcritical thinking ability, concept understanding and cognitive learning achievement of both groups. It was concluded thatimplementation of cognitive conflict approach to physics lesson with pressure topic can grow critical thinking ability, conceptunderstanding and cognitive learning achievement of the JHS student.Keyword: cognitive conflict approach, critical thinking ability, concept understanding, cognitive learning achievement

  6. Human liver sinusoidal endothelial cells but not hepatocytes contain factor VIII.

    Science.gov (United States)

    Shahani, T; Covens, K; Lavend'homme, R; Jazouli, N; Sokal, E; Peerlinck, K; Jacquemin, M

    2014-01-01

    Although the liver is the major site of coagulation factor VIII (FVIII) synthesis, the type of cells producing FVIII within the liver is still unclear. To measure FVIII in extracts of primary liver sinusoidal endothelial cells (LSECs) and hepatocytes, thereby preventing potential bias resulting from the modifications of the cell phenotype that can take place during in vitro culture. LSECs were purified by flow cytometry cell sorting on the basis of their coexpression of Tie2 and CD32b. The purity of the cells was controlled by RNA sequencing. FVIII activity (FVIII:C) in extracts of purified cells was measured with a sensitive FVIII chromogenic assay, in which the specificity of the reaction is controlled by neutralization of FVIII activity with specific inhibitor antibodies. The FVIII:C concentration in purified LSECs ranged from 0.3 to 2.8 nU per cell. In contrast, FVIII:C was undetectable in hepatocytes. The intracellular FVIII:C concentrations are therefore at least 10-100-fold higher in LSECs than in hepatocytes. Our data demonstrate that LSECs, but not hepatocytes, contain measurable amounts of FVIII:C, and suggest that the former are the main cells producing FVIII in the human liver. © 2013 International Society on Thrombosis and Haemostasis.

  7. PENGGUNAAN MIND MAP DIIRINGI MUSIK KLASIK DALAM PEMBELAJARAN MATEMATIKA UNTUK SISWA KELAS VIII SMPN 1 SAWAHLUNTO

    Directory of Open Access Journals (Sweden)

    Rezky Ramadhona

    2016-06-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui apakah motivasi dan hasil belajar belajar matematika siswa kelas VIII SMPN 1 Sawahlunto setelah menggunakan mind map dan musik klasik lebih baik dari sebelum menggunakan mind map dan musik klasik. Jenis penelitian ini adalah penelitian eksperimen dengan menggunakan dua model rancangan yaitu One Group Pretest Posttest Design untuk melihat dampak perlakuan terhadap motivasi belajar dan Randomized Control Group Only Design untuk melihat dampak perlakuan terhadap hasil belajar. Pengumpulan data dalam penelitian ini menggunakan angket dan tes akhir berupa soal essai. Data yang diperoleh dianalisis dengan menggunakan Uji-t. Hasil penelitian menunjukkan bahwa motivasi belajar matematika siswa cenderung meningkat. Jadi disimpulkan bahwa motivasi belajar matematika siswa setelah menggunakan mind map dan musik klasik lebih baik dari pada sebelum menggunakan mind map dan musik klasik. Dari hasil uji hipotesis untuk data hasil belajar pada selang kepercayaan α = 0,05 diperoleh P-value = 0,022. Jadi dapat disimpulkan bahwa hasil belajar matematika siswa yang menggunakan mind map dan musik klasik lebih baik dari hasil belajar matematika siswa yang tidak menggunakan mind map dan musik klasik. Kata Kunci: Mind Map, Musik Klasik DOI: http://dx.doi.org/10.22342/jpm.10.2.3636.87-92

  8. [Determinants of the elevated factor VIII activity in patients following venous thromboembolism].

    Science.gov (United States)

    Lech, Monika; Kościelniak, Barbara; Bryk, Agata; Undas, Anetta

    2016-01-01

    Activity of factor VIII (FVIII) increased above 150% of reference range predisposes to venous thromboembolism (VTE). The aim of this study was to identify predictors of increased FVIII activity in patients following VTE. 241 (38% men) patients presented due to objectively documented VTE episode at least 3 months ago were included in this study. FVIII activity was measured using a clotting assay on the analyzer BCS XP. Among 241 patients with VTE, activity of FVIII above 150% (FVIII ≥ 150%) was observed in 96 (40%). These patients were older (p = 0.035) and their concentrations of fibrinogen and C-reactive protein (CRP) were higher by 12% and 88% (p 200%) and this group was also older (p = 0.015), more patients in that group had obesity (p = 0.015), idiopathic VTE (p = 0.043), less of them had positive family history (p = 0.010) and they were characterized by fibrinogen and CRP increased by 28% (p 200% (p = 0.016). The activity of FVIII in patients after VTE episode is influenced by age, concentration of fibrinogen, bilirubin, hemoglobin, glucose, CRP and homocysteine. Our results suggest the role of environmental factors, mainly inflammatory response in maintaining elevated FVIII activity following VTE.

  9. Transgenic rabbits as a model organism for production of human clotting factor VIII

    International Nuclear Information System (INIS)

    Vasicek, D.; Chrenek, P.; Makarevich, A.; Bauer, M.; Jurcik, R.; Suvegova, K.; Rafay, J.; Bulla, J.; Hetenyi, L.; Erickson, J.; Paleyanda, R.K.

    2005-01-01

    Human clotting factor VIII (hFVIII) is a very complex and large protein whose expression is difficult, as hFVIII requires extensive post-translational modification to be biologically active. This paper reports the generation of transgenic rabbits as a model species for testing the expression of hFVIII in the mammary gland. For micro-injection, a fusion gene construct was used, consisting of 2.5 kb murine whey acidic protein (mWAP) promoter, 7.2 kb cDNA of hFVIII, and 4.6 kb of 3' flanking sequences of the mWAP gene. from 130 micro-injected zygotes transferred into recipients, 30 offspring were delivered. The pups were screened for the transgene by PCR, using DNA isolated from the ear, and results were confirmed by Southern blot analysis. The transgene was identified in one female founder animal, and it was transmitted to the offspring in a Mendelian fashion, thus demonstrating stable integration of the gene construct into the germline of the transgenic rabbits. (author)

  10. Allometry of Factor VIII and informed scaling of next generation therapeutic proteins

    Science.gov (United States)

    Kosloski, Matthew P.; Pisal, Dipak S.; Mager, Donald E.; Balu-Iyer, Sathy V.

    2013-01-01

    Allometric scaling has been applied to the pharmacokinetics (PK) of factor VIII (FVIII), but published relationships are based on relatively small subsets of available data. Numerous next generation forms of FVIII are being developed (e.g. Fc fusion, PEGylated, and liposomal formulations) and traditional pharmacokinetic scaling of these products would not incorporate the wealth of existing knowledge for current FVIII therapy in humans. We conducted a meta-analysis and developed allometric relationships of FVIII from over 100 PK studies collected from literature. Normalized Wajima curves were used to relate mean FVIII profiles between species. An ‘informed scaling’ approach was derived for predicting first-in-human PK parameters and demonstrated with a case study for an Fc fusion FVIII. NCA values for FVIII PK were well described by the allometric equations CL=6.59·W0.85 and Vss=65.0·W0.97. A subset of studies characterized by two compartment modeling showed strong linearity in scaling of total clearance and central volume, but more variability in distributional clearance and peripheral volume. Wajima curves for FVIII superimposed across species and the disposition of Fc fusion FVIII in humans was well predicted by ‘informed scaling.’ This approach might be generally applicable for predicting human PK of next generational therapeutics. PMID:23620343

  11. Phonon dynamics in type-VIII silicon clathrates: Beyond the rattler concept

    Science.gov (United States)

    Norouzzadeh, Payam; Myles, Charles W.; Vashaee, Daryoosh

    2017-05-01

    Clathrates can form a type of guest-host solid structures that, unlike most crystalline solids, have very low thermal conductivity. It is generally thought that the guest atoms caged inside the host framework act as "rattlers" and induce lattice dynamics disorders responsible for the small thermal conductivity. We performed a systematic study of the lattice dynamical properties of type-VIII clathrates with alkali and alkaline-earth guests, i.e., X8S i46 (X =Na , K, Rb, Cs, Ca, Sr, and Ba). The energy dependent participation ratio (PR) and the atomic participation ratio of phonon modes extracted from density functional theory calculations revealed that the rattler concept is not adequate to describe the effect of fillers as they manifest strong hybridization with the framework. For the case of heavy fillers, such as Rb, Sr, Cs, and Ba, a phonon band gap was formed between the acoustic and optical branches. The calculated PR indicated that the fillers suppress the acoustic phonon modes and change the energy transport mechanism from propagative to diffusive or localized resulting in "phonon-glass" characteristics. This effect is stronger for the heavy fillers. Furthermore, in all cases, the guest insertion depressed the phonon bandwidth, reduced the Debye temperature, and reduced the phonon group velocity, all of which should lead to reduction of the thermal conductivity.

  12. Modelos de gestão e o SUS Management models and Brazil's National Health System (SUS

    Directory of Open Access Journals (Sweden)

    Nelson Ibañez

    2007-11-01

    Full Text Available O recente documento do Ministério do Planejamento sobre Fundações Públicas (2005 e a crise da área hospitalar colocaram novamente na agenda do SUS a questão dos modelos de gestão pública. O objetivo deste artigo é situar no contexto das reformas de estado pensadas na década de 90 para o Brasil, as propostas de mudança dos modelos de gestão da administração pública, com foco no processo de implementação do SUS. Essa abordagem trata em primeiro lugar da personalidade jurídica das organizações de saúde na esfera estatal, conceituando o público a partir de seus objetivos; em segundo, discute o contexto as reformas de estado e as mudanças propostas para a administração pública. Os autores entendem que critérios e parâmetros para avaliação institucional devem contemplar quatro aspectos: subordinação à política de saúde; legalidade; eficiência gerencial e capacidade de controle. A partir do quadro de referencia geral elaborou-se uma análise comparativa em relação à proposta das fundações públicas de direito privado. Na análise comparativa das características desse tipo de entidade proposta para gestão hospitalar, observam-se semelhanças com a proposta de Organizações Sociais. Fundação Estatal e Contrato de Gestão podem ser vistos como modelos que possibilitam modernizar o Estado, além de re-introduzirem o tema da reforma hospitalar na agenda governamental brasileira.The recent document on Public Foundations issued by the Ministry of Planning (2005 and the crisis in the hospital area bring the issue of public management models back to the agenda of Brazil's National Health System (SUS. This paper brings up changes in civil service management models within the context of the State restructuring processes of the 1990s in Brazil, particularly in the National Health System (SUS. The approach examines, initially, the legal status of healthcare entities at the State level, establishing their publics by

  13. Docentes de inglés de primaria, secundaria y terciaria: Sus creencias pedagógicas sobre sus estudiantes

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    Claudio Díaz-Larenas

    2015-01-01

    Full Text Available Como agente reflexivo de su propia práctica, el profesorado construye creencias pedagógicas sobre el proceso de enseñanza y aprendizaje y, en particular, sobre el rol que sus estudiantes deben asumir en el aprendizaje de un idioma. Este estudio tiene como objetivo identificar las creencias pedagógicas de treinta docentes de inglés de primaria, secundaria y terciaria, en Chile, sobre el rol estudiantil en el proceso didáctico. Un cuestionario, una entrevista semi-estructurada, un diario auto-biográfico y cinco diarios de observación no-participante fueron utilizados para revelar las creencias pedagógicas de sus informantes. Los datos arrojados por los instrumentos fueron analizados con el programa cualitativo ATLASTI, que permitió el levantamiento de tres dimensiones y diez categorías, mediante el uso de la técnica del análisis de contenido semántico. Los resultados muestran que los tres grupos de profesorado declaran que estudiantes que aprenden una lengua extranjera deben tener características personales y académicas relacionadas con la motivación, la participación, la autonomía, entre otras; sin embargo, al interior del aula asumen un rol pasivo y reactivo frente al ambiente de enseñanza altamente estructurado que genera el personal docente. En conclusión, las creencias que cada docente sostiene se alimentan de la teoría y se corroboran o cuestionan en la práctica de aula, a modo de una relación bidireccional entre teoría y práctica, y viceversa.

  14. Estudio del seno coronario y sus tributarias en individuos colombianos

    Directory of Open Access Journals (Sweden)

    Luis E. Ballesteros, MD., MSc.

    2010-01-01

    Full Text Available La expresión morfológica del seno coronario se caracteriza por su gran variabilidad, especialmente en lo que se relaciona con longitud, calibres, territorios drenados y frecuencia de sus tributarias. Se evaluaron las variaciones del seno coronario en 68 senos coronarios (56 hombres; 12 mujeres de corazones extraídos como material de necropsia, a individuos colombianos. Los senos fueron inyectados con resina sintética y se registraron sus características anatómicas. La longitud promedio de los senos fue de 25,96 mm (± 6,34 y su diámetro distal de 8,94 mm (± 1,66. Las formas fueron cilíndrica, en embudo y aplanada en 67,6%, 23,5% y 8,9% respectivamente. La vena cardiaca magna se originó en el ápex cardiaco en 57,4% de los casos y en el tercio inferior del surco interventricular anterior en 39,7%. A nivel del surco atrioventricular tuvo un calibre de 5,47 mm (± 0,72. En 77,9% la vena cardiaca magna se ubicó a la izquierda de la arteria interventricular anterior. El trígono arterio-venoso del corazón estuvo presente en 58,8%. La vena cardiaca media tuvo como origen el tercio inferior de la superficie ventricular anterior (53% y el ápex cardiaco (47%. Ésta desembocó directamente en el atrio derecho en 17% de los casos. Su calibre en el segmento cercano al seno fue de 4 mm (± 0,77. Se presentó anastomosis de las venas cardiacas magna y media en 58,8%; en el ápex cardiaco (33,8% y en el segmento inferior del surco interventricular anterior. Se destaca la presencia de una vena cardiaca magna corta y de una vena cardiaca media de amplia trayectoria en un número significativo de casos. De igual forma, la desembocadura de la vena cardiaca media en el atrio derecho estuvo presente en casi una quinta parte de los corazones estudiados.

  15. Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII

    Science.gov (United States)

    Lozier, Jay N; Kloos, Mark T; Merricks, Elizabeth P; Lemoine, Nathaly; Whitford, Margaret H; Raymer, Robin A; Bellinger, Dwight A; Nichols, Timothy C

    2016-01-01

    Animals with hemophilia are models for gene therapy, factor replacement, and inhibitor development in humans. We have actively sought dogs with severe hemophilia A that have novel factor VIII mutations unlike the previously described factor VIII intron 22 inversion. A male Old English Sheepdog with recurrent soft-tissue hemorrhage and hemarthrosis was diagnosed with severe hemophilia A (factor VIII activity less than 1% of normal). We purified genomic DNA from this dog and ruled out the common intron 22 inversion; we then sequenced all 26 exons. Comparing the results with the normal canine factor VIII sequence revealed a C→T transition in exon 12 of the factor VIII gene that created a premature stop codon at amino acid 577 in the A2 domain of the protein. In addition, 2 previously described polymorphisms that do not cause hemophilia were present at amino acids 909 and 1184. The hemophilia mutation creates a new TaqI site that facilitates rapid genotyping of affected offspring by PCR and restriction endonuclease analyses. This mutation is analogous to the previously described human factor VIII mutation at Arg583, which likewise is a CpG dinucleotide transition causing a premature stop codon in exon 12. Thus far, despite extensive treatment with factor VIII, this dog has not developed neutralizing antibodies (‘inhibitors’) to the protein. This novel mutation in a dog gives rise to severe hemophilia A analogous to a mutation seen in humans. This model will be useful for studies of the treatment of hemophilia. PMID:27780008

  16. Safety, efficacy and pharmacokinetics of rVIII-SingleChain in children with severe hemophilia A: results of a multicenter clinical trial.

    Science.gov (United States)

    Stasyshyn, O; Djambas Khayat, C; Iosava, G; Ong, J; Abdul Karim, F; Fischer, K; Veldman, A; Blackman, N; St Ledger, K; Pabinger, I

    2017-04-01

    Essentials rVIII-SingleChain is a novel recombinant factor VIII with covalently bonded heavy and light chains. Efficacy, safety and pharmacokinetics were studied in pediatric patients with severe hemophilia A. Across all prophylaxis regimens, the median annualized spontaneous bleeding rate was 0.00. rVIII-SingleChain showed excellent hemostatic efficacy and a favorable safety profile. Background rVIII-SingleChain is a novel B-domain truncated recombinant factor VIII (rFVIII) comprised of covalently bonded FVIII heavy and light chains, demonstrating a high binding affinity to von Willebrand factor. Objectives This phase III study investigated the safety, efficacy and pharmacokinetics of rVIII-SingleChain in previously treated pediatric patients hemophilia A. Patients/Methods Patients could be assigned to prophylaxis or on-demand therapy by the investigator. For patients assigned to prophylaxis, the treatment regimen and dose were based on the bleeding phenotype. For patients receiving on-demand therapy, dosing was guided by World Federation of Hemophilia recommendations. The primary endpoint was treatment success, defined as a rating of 'excellent' or 'good' on the investigator's clinical assessment of hemostatic efficacy for all treated bleeding events. Results The study enrolled 84 patients (0 to 50 EDs. In the 347 bleeds treated and evaluated by the investigator, hemostatic efficacy was rated as excellent or good in 96.3%. The median annualized spontaneous bleeding rate was 0.00 (Q1, Q3: 0.00, 2.20), and the median annualized bleeding rate was 3.69 (Q1, Q3: 0.00, 7.20) across all prophylaxis regimens. No participant developed an inhibitor. Conclusions rVIII-SingleChain is a novel rFVIII molecule showing excellent hemostatic efficacy and a favorable safety profile in a clinical study in children hemophilia A. © 2017 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and

  17. Cartagena de Indias: historiografía de sus fortificaciones

    Directory of Open Access Journals (Sweden)

    Rodolfo Segovia Salas

    1997-05-01

    Full Text Available La historia militar de Cartagena de Indias está ligada a la doble condición de ser centro de intercambio con reputación de opulencia, y de constituirse con el tiempo en puntal geopolítico por sus condiciones defensivas. De estos dos aspectos, el que ha despertado el mayor y más temprano interés historiográfico por su sabor romántico ha sido la narración de los épicos ataques y defensas de la ciudad colonial antes y después de rodearse de murallas de piedra. Desde cuando el noble francés Jean François de la Roque, señor de Roberval , compañero de Cartier en las tempranas expediciones al Canadá y conocido en las crónicas como Roberto Baal u O'valle, la sorprendiera en 1544, Cartagena nunca dejó de vivir bajo la amenaza de "enemigas venganzas".

  18. Las playas de Quintana Roo: sus riesgos y vulnerabilidad.

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    Daniel Torruco Gómez

    2013-01-01

    Full Text Available Las playas son sistemas donde se ejercen presiones antrópicas y ambientales, en este estudio se analizaron sus condiciones bioeconómicas con la finalidad de obtener un modelo que permita determinar el grado de vulnerabilidad y la matriz de riesgo en las playas del Estado de Quintana Roo para un mejor uso sustentable. Se formularon matrices con registros biológicos y socioeconómicos obtenidos entre el 2009 y 2010 en temporadas de alto registro turístico, obteniendo 17 variables en 20 playas analizadas. La evaluación se efectuó con el modelo semiparamétrico del tipo KSIM con dos escenarios: uno sin control/restricción en el desarrollo costero y otro con las mismas características pero con decremento en demanda turística por baja calidad ambiental. Los resultados mostraron un marcado descenso en playas arenosas y costas rocosas. En el modelo se hace referencia a la importancia de los procesos de las playas y su interrelación con los factores biológicos, sociales y económicos más importantes, proporcionando una visión integral de todas las variables. Se recomienda incrementar el modelo dándole mayor envergadura, integrando a las instituciones que influyen en el control de las acciones en estas playas, lo que dará un mejor referente y monitoreo a corto, mediano y largo plazo.

  19. Sindicalismo, SUS e planos de saúde Trade unionism, Unified Health System (SUS and private health insurance

    Directory of Open Access Journals (Sweden)

    José Augusto Pina

    2006-09-01

    Full Text Available Este artigo discute a interlocução do sindicalismo brasileiro com o Sistema Único de Saúde (SUS e os planos e seguros privados de saúde. São ponderadas algumas teses na Saúde Coletiva à luz de estudos mais recentes nas Ciências Sociais sobre o sindicalismo e realizada análise documental para o caso da Central Única dos Trabalhadores (CUT, tomado aqui como referência. Aponta-se a necessidade de considerar os pesos relativos que a ação sindical atribuiu a cada um dos aspectos da relação, SUS e planos privados de saúde, pelas distintas conjunturas do país. O conflito entre trabalhadores e empresas somado ao desemprego e à precarização do trabalho expõe os limites das coberturas assistenciais privadas e impele a representação sindical a pleitear a intervenção estatal. O trabalho refletiu sobre as distintas modalidades de ação sindical na empresa e no Estado. A complexidade dessa dinâmica fez emergir um setor sindical interessado na gestão da previdência complementar e dos planos de saúde e, ao mesmo tempo, recria as circunstâncias e traz novas possibilidades de as organizações sindicais se colocarem na cena política e aglutinar os interesses de amplos segmentos dos trabalhadores para pressionar o Estado na defesa da melhoria do sistema público de saúde.The article intends to discuss the patterns of interlocution between the Brazilian trade unionism, the public health system (SUS and the private health insurance sector. Some thesis originated in the Public Health area about the subject are debated, in the light of more recent Social Science's studies concerned the Brazilian unionism. It presents a documentary analysis for the case of the largest National Workers Organization, named CUT. The need to discuss the problem in distinct political and economic conjunctures of the country is pointed out. The conflicts between the workers and the companies, added to the unemployment and deregulation of the labor markets

  20. A Model for Predicting Persistent Elevation of Factor VIII among Patients with Acute Ischemic Stroke

    Science.gov (United States)

    Samai, Alyana A.; Boehme, Amelia K.; Shaban, Amir; George, Alexander J.; Dowell, Lauren; Monlezun, Dominique J.; Leissinger, Cindy; Schluter, Laurie; El Khoury, Ramy; Martin-Schild, Sheryl

    2016-01-01

    Background and Purpose Elevated levels of coagulation factor VIII (FVIII) may persist independent of the acute-phase response; however, this relationship has not been investigated relative to acute ischemic stroke (AIS). We examined the frequency and predictors of persistently elevated FVIII in AIS patients. Methods AIS patients admitted between July 2008 and May 2014 with elevated baseline FVIII levels and repeat FVIII levels drawn for more than 7 days postdischarge were included. The patients were dichotomized by repeat FVIII level for univariate analysis at 150% and 200% activity thresholds. An adjusted model was developed to predict the likelihood of persistently elevated FVIII levels. Results Among 1616 AIS cases, 98 patients with elevated baseline FVIII had repeat FVIII levels. Persistent FVIII elevation was found in more than 75% of patients. At the 150% threshold, the prediction score ranged from 0 to 7 and included black race, female sex, prior stroke, hyperlipidemia, smoking, baseline FVIII > 200%, and baseline von Willebrand factor (vWF) level greater than 200%. At the 200% threshold, the prediction score ranged from 0–5 and included female sex, prior stroke, diabetes mellitus, baseline FVIII level greater 200%, and baseline vWF level greater than 200%. For each 1-point increase in score, the odds of persistent FVIII at both the 150% threshold (odds ratio [OR] = 10.4, 95% confidence interval [CI] 1.63–66.9, P = .0134) and 200% threshold (OR = 10.2, 95% CI 1.82–57.5, P = .0083) increased 10 times. Conclusion Because an elevated FVIII level confers increased stroke risk, our model for anticipating a persistently elevated FVIII level may identify patients at high risk for recurrent stroke. FVIII may be a target for secondary stroke prevention. PMID:26777556

  1. To serve and protect: The modulatory role of von Willebrand factor on factor VIII immunogenicity.

    Science.gov (United States)

    Hartholt, Robin B; van Velzen, Alice S; Peyron, Ivan; Ten Brinke, Anja; Fijnvandraat, Karin; Voorberg, Jan

    2017-09-01

    Hemophilia A is a bleeding disorder characterized by the absence or dysfunction of blood coagulation factor VIII (FVIII). Patients are treated with regular infusions of FVIII concentrate. In response to treatment, approximately 30% of patients with severe hemophilia A develop inhibitory antibodies targeting FVIII. Both patient and treatment related risk factors for inhibitor development have been described. Multiple studies comparing the immunogenicity of recombinant and plasma-derived FVIII have yielded conflicting results. The randomized controlled SIPPET (Survey of Inhibitors in Plasma-Product Exposed Toddlers) trial demonstrated an increased risk of inhibitor development of recombinant FVIII when compared to von Willebrand factor (VWF)-containing plasma-derived FVIII. Presently, it is unclear which mechanism underlies the reduced immunogenicity of plasma-derived FVIII. In this review we address the potential role of VWF on FVIII immunogenicity and we discuss how VWF affects the immune recognition, processing and presentation of FVIII. We also briefly discuss the potential impact of glycan-composition on FVIII immunogenicity. It is well established that VWF shields the uptake of FVIII by antigen presenting cells. We have recently shown that VWF binds to the surface of dendritic cells. Here, we present a novel model in which surface bound FVIII-VWF complexes regulate the internalization of FVIII. Binding of FVIII to VWF is critically dependent on sulfation of Tyr1699 (HVGS numbering) in the light chain of FVIII. Incomplete sulfation of Tyr1699 has been suggested to occur in several recombinant FVIII products resulting in a loss of VWF binding. We hypothesize that this results in alternative pathways of FVIII internalization by antigen presenting cells which are not regulated by VWF. This hypothetical mechanism may explain the reduced immunogenicity of VWF containing plasma-derived FVIII concentrates as found in the SIPPET study. Copyright © 2017. Published by

  2. Complement C3 is a novel modulator of the anti-factor VIII immune response.

    Science.gov (United States)

    Rayes, Julie; Ing, Mathieu; Delignat, Sandrine; Peyron, Ivan; Gilardin, Laurent; Vogel, Carl-Wilhelm; Fritzinger, David C; Frémeaux-Bacchi, Véronique; Kaveri, Srinivas V; Roumenina, Lubka T; Lacroix-Desmazes, Sébastien

    2018-02-01

    Development of neutralizing antibodies against therapeutic Factor VIII (FVIII) is the most serious complication of the treatment of hemophilia A. There is growing evidence to show the multifactorial origin of the anti-FVIII immune response, combining both genetic and environmental factors. While a role for the complement system on innate as well as adaptive immunity has been documented, the implication of complement activation on the onset of the anti-FVIII immune response is unknown. Here, using in vitro assays for FVIII endocytosis by human monocyte-derived dendritic cells and presentation to T cells, as well as in vivo complement depletion in FVIII-deficient mice, we show a novel role for complement C3 in enhancing the immune response against therapeutic FVIII. In vitro , complement C3 and its cleavage product C3b enhanced FVIII endocytosis by dendritic cells and presentation to a FVIII-specific CD4 + T-cell hybridoma. The C1 domain of FVIII had previously been shown to play an important role in FVIII endocytosis, and alanine substitutions of the K2092, F2093 and R2090 C1 residues drastically reduce FVIII uptake in vitro Interestingly, complement activation rescued the endocytosis of the FVIII C1 domain triple mutant. In a mouse model of severe hemophilia A, transient complement C3 depletion by humanized cobra venom factor, which does not generate anaphylatoxin C5a, significantly reduced the primary anti-FVIII immune response, but did not affect anti-FVIII recall immune responses. Taken together, our results suggest an important adjuvant role for the complement cascade in the initiation of the immune response to therapeutic FVIII. Copyright© 2018 Ferrata Storti Foundation.

  3. Nonneutralizing antibodies against factor VIII and risk of inhibitor development in severe hemophilia A.

    Science.gov (United States)

    Cannavò, Antonino; Valsecchi, Carla; Garagiola, Isabella; Palla, Roberta; Mannucci, Pier Mannuccio; Rosendaal, Frits R; Peyvandi, Flora

    2017-03-09

    The development of anti-factor VIII (FVIII) neutralizing antibodies (inhibitors) is the major complication in hemophilia A. Nonneutralizing antibodies (NNAs) have been detected in hemophilia patients and also in unaffected individuals. The aim of this study was to assess the prevalence of NNAs and to evaluate whether their presence is associated with the development of inhibitors in a cohort of previously untreated or minimally treated patients with hemophilia A; plasma samples of 237 patients with severe hemophilia A enrolled in the SIPPET trial were collected before any exposure to FVIII concentrates and analyzed for the presence of anti-FVIII NNAs. Patients were observed for the development of neutralizing antibodies. NNAs were found in 18 (7.6%) of 237 patients at screening, and there was a clear age gradient. Of those with NNAs, 7 patients subsequently developed an inhibitor for a cumulative incidence of 45.4% (95% confidence interval [CI], 19.5% to 71.3%); among the 219 patients without NNAs, 64 (29%) developed an inhibitor (cumulative incidence, 34.0%; 95% CI, 27.1%-40.9%). In Cox regression analyses, patients with NNAs at screening had an 83% higher incidence of inhibitor development than patients without NNAs (hazard ratio [HR], 1.83; 95% CI, 0.84-3.99). For high-titer inhibitors, the incidence rate had an almost threefold increase (HR, 2.74; 95% CI, 1.23-6.12). These associations did not materially change after adjustment. The presence of anti-FVIII NNAs in patients with severe hemophilia A who were not previously exposed to FVIII concentrates is associated with an increased incidence of inhibitors. © 2017 by The American Society of Hematology.

  4. Rancang Bangun Perangkat Eksperimen Hukum Archimedes untuk MTs LB/A Yaketunis Kelas VIII

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    Rofiqoh Utami

    2014-06-01

    Full Text Available Blind students find difficulties whenever they are involved in the experiment of Archimedes principle as it requests an active visual role. Thus, it is very important to design a special tool for blind students so their practice of Archimedes principle become easier. This paper discusses a research finding which is an innovation of adaptive tools for blind students, such as beaker glass with Braille number, dynamometer with modification and Braille number (Braille Spring Balance and recording lesson about Archimedes principle. This research done for students MTs LB / A Yaketunis Class VIII which aims at analyzing the quality of each tool by media experts, lesson experts, and physics teacher of MTs LB/A.This research is R & D with procedural models adapted from the development of the 4-D models, namely Define, Design, Develop, and Disseminate. According to media expert assessment, beaker glass with Braille number and Braille spring balance has a very good quality with percentage of their respective 100% of the ideal score, while the assessment by lesson experts for each tool have a good quality with percentage 80% and 73.33% of the ideal score, and physics teacher of MTs LB / A assessment for each tool have a very good quality with percentage 100%. According to the media and lesson experts, the recording lesson about Archimedes principle have a good quality with percentage 80% of the ideal score, according to physics teacher MTs LB / A, the recording tool has excellent quality either with percentage 91.82% of the ideal score. This research recommends the blinds students to utilize these innovative-adaptive tools which will enable them appropriately practice Archimedes principle as non-blind students.

  5. STUDI KOMPARASI PEMBELAJARAN NOVICK DAN GROUP INVESTIGATION TERHADAP KEMAMPUAN SPASIAL SISWA KELAS VIII MATERI GEOMETRI

    Directory of Open Access Journals (Sweden)

    Dian Nailis Suroyya

    2015-03-01

    Full Text Available Tujuan penelitian ini adalah mengetahui apakah apakah rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Novick lebih baik dari rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Direct Instruction, mengetahui apakah rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Group Investigation lebih baik dari rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Direct Instruction, mengetahui apakah rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Novick lebih baik dari rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Group Investigation, dan mengetahui apakah peningkatan kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Novick lebih baik dari peningkatan kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Group Investigation. Populasi dalam penelitian ini adalah seluruh siswa kelas VIII MTs N 1 Kudus tahun pelajaran 2013/2014. Pengambilan sampel menggunakan teknik random sampling. Data diperoleh melalui metode tes dan data dianalisis menggunakan uji t. Hasil penelitian menunjukkan bahwa rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Novick dan rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Group Investigation lebih baik dari rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Direct Instruction, rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Novick kurang dari atau sama dengan kemampuan rata-rata kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Group Investigation, dan peningkatan kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Novick kurang dari atau sama dengan peningkatan kemampuan spasial siswa pada kelas yang menggunakan model pembelajaran Group

  6. Frequencies of VNTR and RFLP polymorphisms associated with factor VIII gene in Singapore

    Energy Technology Data Exchange (ETDEWEB)

    Fong, I.; Lai, P.S.; Ouah, T.C. [National Univ. of Singapore (Malaysia)] [and others

    1994-09-01

    The allelic frequency of any polymorphism within a population determines its usefulness for genetic counselling. This is important in populations of non-Caucasian origin as RFLPs may significantly differ among ethnic groups. We report a study of five intragenic polymorphisms in factor VIII gene carried out in Singapore. The three PCR-based RFLP markers studied were Intron 18/Bcl I, Intron 19/Hind III and Intron 22/Xba I. In an analysis of 148 unrelated normal X chromosomes, the allele frequencies were found to be A1 = 0.18, A2 = 0.82 (Bcl I RFLP), A1 = 0.80, A2 = 0.20 (Hind III RFLP) and A1 = 0.58, and A2 = 0.42 (Xba I RFLP). The heterozygosity rates of 74 females analyzed separately were 31%, 32% and 84.2%, respectively. Linkage disequilibrium was also observed to some degree between Bcl I and Hind III polymorphism in our population. We have also analyzed a sequence polymorphism in Intron 7 using hybridization with radioactive-labelled {sup 32}P allele-specific oligonucleotide probes. This polymorphism was not very polymorphic in our population with only 2% of 117 individuals analyzed being informative. However, the use of a hypervariable dinucleotide repeat sequence (VNTR) in Intron 13 showed that 25 of our of 27 (93%) females were heterozygous. Allele frequencies ranged from 1 to 55 %. We conclude that a viable strategy for molecular analysis of Hemophilia A families in our population should include the use of Intron 18/Bcl I and Intron 22/Xba I RFLP markers and the Intron 13 VNTR marker.

  7. Valor preditivo da expressão dos anticorpos Antifator VIII no carcinoma epidermóide do esôfago Predictive value of antifactor VIII antibody expression in squamous cell carcinoma of the esophagus

    Directory of Open Access Journals (Sweden)

    Sebastião Gonzaga Barbosa-Neto

    2007-12-01

    Full Text Available RACIONAL: O carcinoma epidermóide do esôfago apresenta alta mortalidade, baixo índice de diagnóstico precoce e altos custos nos tratamentos, com resultados freqüentemente desapontadores e prognóstico sombrio. O melhor entendimento das técnicas de biologia molecular com citofotometria de imagem, permitiu avançar no conhecimento das alterações na expressão das proteínas desse câncer. OBJETIVOS: Quantificar a expressão das proteínas envolvidas na angiogênese e correlacioná-las com variáveis clínico-patológicas. MÉTODOS: Com o uso da técnica de imunoistoquímica, citofotometria de imagem pelo sistema SAMBA, foram analisadas 29 amostras de carcinoma epidermóide do esôfago incluídas em blocos de parafina. Critérios clínicos como idade, sexo e histopatológicos do grau de diferenciação tumoral, tamanho e localização do tumor foram analisados. Os parâmetros analisados foram o índice de marcagem e a densidade óptica. O marcador utilizado foi o anticorpo anti-Fator VIII. RESULTADOS: Foi possível verificar que as expressões médias do marcador no índice de marcagem foram maiores que as da densidade óptica. Fator VIII apresentou leituras homogêneas. O índice de marcagem foi de 80,17+/-10,40 com P=0,073 e a densidade óptica 51,25+/-11,02 com P=0,245. CONCLUSÃO: A análise quantificação da expressão das proteínas envolvidas na angiogênese permite definir subgrupos de acordo com a diferenciação do carcinoma, estágio tumoral, tamanho e localização do tumor, porém não associa-se com o sexo e a idade dos pacientes, e a densidade óptica do Fator VIII não tem expressão significativa em nenhum dos subgrupos analisados.BACKGROUND: Squamous cell carcinoma of the esophagus exhibits high mortality rate, rare precocious diagnosis, and expensive treatments, presenting frequently disappointed results and poor prognosis. The better understanding about Molecular Biology techniques using cytophotometric imaging allowed

  8. Corrosion property for solid state bonded joint of SUS304L stainless steel and Zr; SUS304L ko to Zr ko tono koso setsugo tsugite no taishokusei

    Energy Technology Data Exchange (ETDEWEB)

    Ei, K.; Irie, H.; Kasugai, T. [National Research Institute for Metals, Tsukuba (Japan)

    1999-05-01

    Corrosion resistance of diffusion bonded joint with Ta foil inserted between the bonded surfaces and friction welding joint for SUS304L and Zr was examined in 3N-HNO{sub 3} solution contained Cr{sup 6+} ion. In a short term dipping test, it was difficult to qualitatively investigate the corrosion property for both joints, because it depended strongly on the surface condition (preparation) of the specimen before the test. In a long term dipping test, however, the type of the corrosion was mainly found intergranular corrosion in SUS304L base metal for all of the joints, moreover this developed the falling off the crystal grain of SUS304L base metal. In this corrosion process, a possibility that galvanic potential difference between dissimilar metals accelerated corrosion was pointed out, then local potential gradient was investigated using a measuring system, in which a sharp vibrating probe was scanned across the joint interface. SUS304L base metal showed a positive local potential gradient which indicated on acceleration of corrosion in SUS304L. But it was not so large and corrosion rates of SUS304L for the both solid state joining were nearly same value as that without Zr or Ta base metals. The acceleration of the corrosion at dissimilar metal joints were not observed from the results of the dipping test and the measurement of the local potential gradient, it is considered that there is no problem of the corrosion resistance in these joints. (author)

  9. Difference in cold-working effect on the irradiation-induced deformation between SUS 316L and SUS 304 stainless steel

    International Nuclear Information System (INIS)

    Nagakawa, Johsei; Murase, Yoshiharu; Yamamoto, Norikazu; Ueno, Keiko

    2007-01-01

    SUS 304 stainless steel has been used for internal components of the light-water reactors constructed in earlier days, in which irradiation-assisted stress corrosion cracking has drawn attention. SUS 316L was regarded as less susceptible to the stress corrosion cracking and adopted in the newer reactors, although it was recently found not completely so in some Japanese reactors. Tensile residual stress introduced during manufacturing is believed to be one of the major factors in the initiation of cracking. It is, therefore, essential to assess the stress relaxation behavior under irradiation, which can be evaluated from the irradiation creep data, in conjunction with the effect of cold work. In the present study, creep experiments under 17MeV proton irradiation (2x10 -7 dpa/s) at 288degC were conducted for both SUS 316L and SUS 304 stainless steels with 5% or 25% cold work. Stress dependence of the irradiation creep was quite different between the two stainless steels, almost linear in SUS 316L while nearly quadratic in SUS 304 for both levels of cold-working. Stress relaxation under irradiation was evaluated to be different between the two stainless steels, reflecting their difference in stress dependence. (author)

  10. Desenvolvimento do sus e racionamento de serviços hospitalares SUS evolution and hospital services rationing

    Directory of Open Access Journals (Sweden)

    José Mendes Ribeiro

    2009-06-01

    Full Text Available Analisamos o sistema de saúde brasileiro em perspectiva comparada. A migração de clientelas de renda média para operadoras pré-pagas privadas aproxima o caso brasileiro do norte-americano. A produção de serviços hospitalares no SUS demonstra importante redução da oferta agravada pelo crescimento demográfico e por expectativas definidas por disposições constitucionais. A redução é seletiva e concentrada em serviços obstétricos e de clínica médica e nos serviços privados lucrativos. Para se garantir acesso equitativo é necessário: ampliação de gastos públicos; redução dos gastos por desembolso direto; reformas organizacionais; ampliação da capacidade de governo.We analyze Brazilian health system in comparative perspective. Middle income beneficiaries migration to pre-paid private insurance makes Brazilian case similar to United States. Public hospital services delivery shows an important retrenchment enhanced by demographic growth and new expectations due to constitutional definitions. Retrenchment is selective and concentrates on obstetric and clinic services and private for-profit services. To ensure equal access it is necessary to improve public spending; diminish out-of-pocket spending; develop organizational reforms; improve government capacity.

  11. The Effect of Growth Temperature and V/III Flux Ratio of MOCVD Antimony Based Semiconductors on Growth Rate and Surface Morphology

    Directory of Open Access Journals (Sweden)

    Ramelan Ari Handono

    2017-01-01

    Full Text Available Epitaxial Alx Ga1-x Sb layers on GaSb and GaAs substrates have been grown by atmospheric pressure metalorganic chemical vapor deposition using TMAl, TMGa and TMSb. Nomarski microscope and a profiler were employed to examine the surface morphology and growth rate of the samples. We report the effect of growth temperature and V/III flux ratio on growth rate and surface morphology. Growth temperatures in the range of 520°C and 680°C and V/III ratios from 1 to 5 have been investigated. A growth rate activation energy of 0.73 eV was found. At low growth temperatures between 520 and 540°C, the surface morphology is poor due to antimonide precipitates associated with incomplete decomposition of the TMSb. For layers grown on GaAs at 580°C and 600°C with a V/III ratio of 3 a high quality surface morphology is typical, with a mirror-like surface and good composition control. It was found that a suitable growth temperature and V/III flux ratio was beneficial for producing good AlGaSb layers. Undoped AlGaSb grown at 580°C with a V/III flux ratio of 3 at the rate of 3.5 μm/hour shows p-type conductivity with smooth surface morphology

  12. La Corona Española y sus Leyes

    Directory of Open Access Journals (Sweden)

    Jaime Herrera Pontón

    1995-04-01

    Full Text Available

    Bogotá, Mayo 27 de 1994

    Señor Académico
    Zoilo Cuéllar Montoya
    Secretario
    Academia Nacional de Medicina

    E. S. D.

    Muy estimado doctor Cuéllar:

    En la última reunión de la Academia, el académico De Zubiría, mencionó que el consumo de coca ya estaba penalizado desde la época de la Colonia. Me permito enviarle una copia de lo referente a la coca que se encuentra en las Leyes dictadas por la Corona Española en relación con este tema. Está tomado de la tercera edición de la recopilación que se hizo de dichas leyes en el año de 1774, por orden del Rey don Carlos Ir, del 7 de febrero de dicho año.

    Como es una fiel copia del original, he respetado la ortografía usada en él.

    Atentamente,
    Jaime Herrera Pontón

    Recopilación de leyes de los reynos de las Indias
    Año de 1774, tercera edición, Madrid.

    TÍTULO CATORCE
    Del servicio en Coca y Añir

    – Ley primera. Que los Indios, que trabajan, en la Coca sean bien tratados, y no usen de ella en supersticiones y hechicerías.

    D. Felipe Segundo en Madrid a 18 de Octubre de 1569

    Somos informados que de la costumbre de los Indios del Perú tienen en el uso de la Coca, y su
    grangería, se siguen grandes inconvenientes, por ser mucha parte para sus idolatrías, ceremonias, y hechicerías, y fingen, que trayéndola en la boca les da más fuerza y vigor para el trabajo, que según afirman los experimentados es ilusión de el Demonio, y en su beneficio perecen infinidad de Indios, que por ser cálida, y enferma la parte donde se cría, e ir a ella de tierra fría, de que mueren muchos, y otros salen tan enfermos, y débiles, que no se pueden reparar.

    Y aunque nos fue suplicado, que la mandássemos, porque desamas no quitar a los Indios este genero de alivio para el trabajo, aunque solo consista en la imaginación: Ordenamos a los Virreyes, que probean como los Indios, que se emplean en el

  13. Maltrato infantil y sus consecuencias a largo plazo

    Directory of Open Access Journals (Sweden)

    Laura Carolina Alarcón Forero

    2010-01-01

    Full Text Available La violencia intrafamiliar constituye una de las formas más frecuentes de violencia encontradas tanto a nivel nacional como internacional y dentro de estas el maltrato infantil presenta cifras alarmantes, y es el objeto de nuestra revisión. Los efectos de este problema repercuten notablemente en aquellos que sobreviven, ya que las consecuencias a largo plazo del maltrato infantil son más perjudiciales para lasvíctimas y sus familias, y más costoso para la sociedad, que las lesiones agudas inmediatas que puedan producir. Las consecuencias a largo plazo para estos niños varían desde efectos nocivos en su desarrollo hasta trastornos psicológicos, psiquiátricos y orgánicos. Es importante resaltar que aún con muy buenas intervenciones no todas tienen el éxito esperado si no se hacen de manera correcta. Esindispensable contar con estrategias de prevención que incluyan personal bien entrenado, una supervisión adecuada, los recursos necesarios, y un tiempo mínimo óptimo para enfrentar el problema y obtener los mejores resultados. ______________________________________________________________________Domestic violence is one of the most common forms of violence found both domestically and internationally. Within these, child abuse has alarming figures. This is the subject of this review. The effects of this problem significantly impact on those who survive; their long-term consequences are most severe and expensive for victimized child and his/her family than associated primary physical injuries. Thelong-term consequences for these children range from adverse effects on its psycholigical development to psychological, psychiatric organic disoders. It is important to note that good speeches are not enough to achieve success if any intervention are not done correctly. All prevention strategies include well-trained staff, appropriate supervision, resources, and a optimal time for addressing this problem to get the best results.

  14. EFFECT OF INFORMATION SERVICES USING THE MEDIA FILM TO SELF-CONFIDENCE STUDENT OF CLASS VIII SMP NEGERI 8 METRO

    Directory of Open Access Journals (Sweden)

    MUDAIM MUDAIM

    2015-06-01

    Full Text Available Abstract: Pessimism and attitudes that consider themselves weak and does not have the ability when facing a problem will make individual impediment in the task of development. Problems confidence that underlies the research are: a Students are less confident in the ability it has, b Students feel pessimistic when faced with an issue, c Student perception subjectively, d Students still do not do the work independently, and e negative minded students with a state-owned. The problems of this study are whether there is an influence of information services using the medium of film to the confidence of eighth-grade students of SMP Negeri 8 Metro. The purpose of this study was to determine whether there is an influence of information services using the medium of film to the self-confidence of students in class VIII SMP Negeri 8 Metro. Subject participant is graders VIII-E total 30 students. Data were collected by questionnaire self-confidence and analyzed the data used is the t-test. The results of this study, shown by the difference in change scores of confidence from the pre-test and post-test of 17.1. Testing the hypothesis obtained calculation results thitung6,036> table = 1.699. The conclusion is that the information services implemented using the film medium can be a positive influence on self-esteem, especially students of class VIII. The advice given is to use the medium of film should be done intensively and more creative by BK teachers in giving information service. Keywords: Confidence, Service Information Using Media Film.

  15. Seleucid, Demotic and Mediterranean mathematics versus Chapters VIII and IX of the Nine Chapters: accidental or significant similarities?

    DEFF Research Database (Denmark)

    Høyrup, Jens

    Similarities of geometrical diagrams and arithmetical structures of problems have often been taken as evidence of transmission of mathematical knowledge or techniques between China and “the West”. Confronting on one hand some problems from Chapter VIII of the Nine Chapters with comparable problems...... known from Ancient Greek sources, on the other a Seleucid collection of problems about rectangles with a subset of the triangle problems from Chapter IX, it is concluded, (1) that transmission of some arithmetical riddles without method – not “from Greece” but from a transnational community of traders...

  16. Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A.

    Science.gov (United States)

    Young, G; Mahlangu, J; Kulkarni, R; Nolan, B; Liesner, R; Pasi, J; Barnes, C; Neelakantan, S; Gambino, G; Cristiano, L M; Pierce, G F; Allen, G

    2015-06-01

    Prophylactic factor replacement, which prevents hemarthroses and thereby reduces the musculoskeletal disease burden in children with hemophilia A, requires frequent intravenous infusions (three to four times weekly). Kids A-LONG was a phase 3 open-label study evaluating the safety, efficacy and pharmacokinetics of a longer-acting factor, recombinant factor VIII Fc fusion protein (rFVIIIFc), in previously treated children with severe hemophilia A (endogenous FVIII level of hemophilia A. © 2015 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

  17. Evaluation of the integrity of reactor vessels designed to ASME Code, Sections I and/or VIII

    International Nuclear Information System (INIS)

    Hoge, K.G.

    1976-01-01

    A documented review of nuclear reactor pressure vessels designed to ASME Code, Sections I and/or VIII is made. The review is primarily concerned with the design specifications and quality assurance programs utilized for the reactor vessel construction and the status of power plant material surveillance programs, pressure-temperature operating limits, and inservice inspection programs. The following ten reactor vessels for light-water power reactors are covered in the report: Indian Point Unit No. 1, Dresden Unit No. 1, Yankee Rowe, Humboldt Bay Unit No. 3, Big Rock Point, San Onofre Unit No. 1, Connecticut Yankee, Oyster Creek, Nine Mile Point Unit No. 1, and La Crosse

  18. Love and/in psychoanalysis: a commentary on Lacan's reading of Plato's Symposium in Seminar VIII: Transference.

    Science.gov (United States)

    Fink, Bruce

    2015-02-01

    What is love and what part does it play in psychoanalysis? Where are the analyst and the analysand situated in relation to the roles defined as those of the "lover" and the "beloved"? Jacques Lacan explores these and other questions in his soon-to-be-published Seminar VIII: Transference by providing an extensive commentary on Plato's most famous dialogue on love, the Symposium. This paper outlines some of the major points about love that grow out of Lacan's reading of the dialogue and examines their relevance to the analytic setting. Can the analyst be characterized as a sort of modern-day Socrates?

  19. EK(b)P Keskkomitee VIII pleenumi stenogramm / tõlk. Mart Arold, tõlk. Jaan Isotamm

    Index Scriptorium Estoniae

    1999-01-01

    EK(b)P Keskkomitee VIII pleenum, 21.-23. märts 1950. Sõnavõtud: N. Karotamm, P. Ponomarenko, I. Käbin, V. Kuusik, A. Jaanus, V. Hiznjakov, E. Ristimägi, I. Suija, H. Ajo, A. Meri, G. Abels, M. Assin, G. Latõshov, Rumjantsev, Müürisepp. Kommenteerinud Viktor Niitsoo. Algus: Akadeemia (1998) nr. 12, lk. 2655-2683 ; Järg nr.2;3;4;5;6;7;8;9;10 lk.415-446;639-670;863-894;1087-1118;1310-1342;1534-1566;1759-1790;2017-2048;2220-2256

  20. Paleopatología dental de una muestra esquelética de Tarraco (Siglos I-VIII)

    OpenAIRE

    Salagaray García, Maria Teresa

    2017-01-01

    Las patologías dentales nos permiten comprender no solo esl estado de salud, sino también el progreso económico, social y cultural de las poblaciones pretéritas. La presente muestra consta de 332 individuos, 6240 dientes pertenecientes a diez yacimientos de Tarraco comprendidos entre los siglos I y VIII d.C. El presente trabajo pretende no sólo conocer la prevalencia de los dientes perdidos ante mortem, caries, reabsorción alveolar, cálculo, fístula, desgaste e hipoplasia sino también la rela...

  1. La neorruralidad y sus significados. El caso de Navarra

    Directory of Open Access Journals (Sweden)

    Rivera, María Jesús

    2009-08-01

    que esta apuesta residencial tuvo para sus protagonistas.

  2. Synthesis of dispersive iron or iron–silver nanoparticles on engineered capsid pVIII of M13 virus with electronegative terminal peptides

    International Nuclear Information System (INIS)

    Zhang, Shuai; Nakano, Kazuhiko; Zhang, Shu-liang; Yu, Hui-min

    2015-01-01

    M13 is a filamentous Escherichia coli virus covered with five types of capsid proteins, in which pVIII with ∼2700 copies was around the cylindered surface and pIII with five copies located at one end of the phage particle. The pIII-engineered M13 phages with enhanced binding specificity toward Fe were screened after five rounds of biopanning, and the one containing ATPTVAMSLSPL peptide at pIII-terminus was selected for mediated synthesis of zero valent (ZV) Fe nanoparticles (NPs) with the wild M13 as control. Under a reducing environment, uniformly dispersed ZVFeNPs with diameter of 5–10 nm were both synthesized and the morphologies after annealing were confirmed to be face-centered cubic type. The synthesized FeNPs mediated by the two phages showed no significant difference, revealing that the pVIII capsid did dominant contribution to metal binding in comparison with the pIII. A novel pVIII-engineered M13 containing AAEEEDPAK at terminus, named as 4ED-pVIII-M13, was constructed and it carried one more negatively charged residue than the wild one (AEGDDPAK). Metal adsorption quantification showed that the binding affinity of the 4ED-pVIII-M13 toward Ag and Ni ions improved to 62 and 18 % from original 21 and 6 %, respectively. The binding affinity toward Fe remained constant (∼85 %). ZVFe–Ag bi-NPs were successfully synthesized through mediation of 4ED-pVIII-M13. Particularly, the Fe:Ag ratio in the bi-NPs was conveniently controlled through changing the molar concentration of FeCl 2 and AgNO 3 solution before reduction

  3. Synthesis of dispersive iron or iron-silver nanoparticles on engineered capsid pVIII of M13 virus with electronegative terminal peptides

    Science.gov (United States)

    Zhang, Shuai; Nakano, Kazuhiko; Zhang, Shu-liang; Yu, Hui-min

    2015-10-01

    M13 is a filamentous Escherichia coli virus covered with five types of capsid proteins, in which pVIII with 2700 copies was around the cylindered surface and pIII with five copies located at one end of the phage particle. The pIII-engineered M13 phages with enhanced binding specificity toward Fe were screened after five rounds of biopanning, and the one containing ATPTVAMSLSPL peptide at pIII-terminus was selected for mediated synthesis of zero valent (ZV) Fe nanoparticles (NPs) with the wild M13 as control. Under a reducing environment, uniformly dispersed ZVFeNPs with diameter of 5-10 nm were both synthesized and the morphologies after annealing were confirmed to be face-centered cubic type. The synthesized FeNPs mediated by the two phages showed no significant difference, revealing that the pVIII capsid did dominant contribution to metal binding in comparison with the pIII. A novel pVIII-engineered M13 containing AAEEEDPAK at terminus, named as 4ED-pVIII-M13, was constructed and it carried one more negatively charged residue than the wild one (AEGDDPAK). Metal adsorption quantification showed that the binding affinity of the 4ED-pVIII-M13 toward Ag and Ni ions improved to 62 and 18 % from original 21 and 6 %, respectively. The binding affinity toward Fe remained constant ( 85 %). ZVFe-Ag bi-NPs were successfully synthesized through mediation of 4ED-pVIII-M13. Particularly, the Fe:Ag ratio in the bi-NPs was conveniently controlled through changing the molar concentration of FeCl2 and AgNO3 solution before reduction.

  4. Synthesis of dispersive iron or iron–silver nanoparticles on engineered capsid pVIII of M13 virus with electronegative terminal peptides

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Shuai; Nakano, Kazuhiko; Zhang, Shu-liang; Yu, Hui-min, E-mail: yuhm@tsinghua.edu.cn [Tsinghua University, Key Laboratory of Industrial Biocatalysis of the Ministry of Education, Department of Chemical Engineering (China)

    2015-10-15

    M13 is a filamentous Escherichia coli virus covered with five types of capsid proteins, in which pVIII with ∼2700 copies was around the cylindered surface and pIII with five copies located at one end of the phage particle. The pIII-engineered M13 phages with enhanced binding specificity toward Fe were screened after five rounds of biopanning, and the one containing ATPTVAMSLSPL peptide at pIII-terminus was selected for mediated synthesis of zero valent (ZV) Fe nanoparticles (NPs) with the wild M13 as control. Under a reducing environment, uniformly dispersed ZVFeNPs with diameter of 5–10 nm were both synthesized and the morphologies after annealing were confirmed to be face-centered cubic type. The synthesized FeNPs mediated by the two phages showed no significant difference, revealing that the pVIII capsid did dominant contribution to metal binding in comparison with the pIII. A novel pVIII-engineered M13 containing AAEEEDPAK at terminus, named as 4ED-pVIII-M13, was constructed and it carried one more negatively charged residue than the wild one (AEGDDPAK). Metal adsorption quantification showed that the binding affinity of the 4ED-pVIII-M13 toward Ag and Ni ions improved to 62 and 18 % from original 21 and 6 %, respectively. The binding affinity toward Fe remained constant (∼85 %). ZVFe–Ag bi-NPs were successfully synthesized through mediation of 4ED-pVIII-M13. Particularly, the Fe:Ag ratio in the bi-NPs was conveniently controlled through changing the molar concentration of FeCl{sub 2} and AgNO{sub 3} solution before reduction.

  5. Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

    Science.gov (United States)

    Dumont, Jennifer A.; Liu, Tongyao; Low, Susan C.; Zhang, Xin; Kamphaus, George; Sakorafas, Paul; Fraley, Cara; Drager, Douglas; Reidy, Thomas; McCue, Justin; Franck, Helen W. G.; Merricks, Elizabeth P.; Nichols, Timothy C.; Bitonti, Alan J.; Pierce, Glenn F.

    2012-01-01

    Despite proven benefits, prophylactic treatment for hemophilia A is hampered by the short half-life of factor VIII. A recombinant factor VIII-Fc fusion protein (rFVIIIFc) was constructed to determine the potential for reduced frequency of dosing. rFVIIIFc has an ∼ 2-fold longer half-life than rFVIII in hemophilia A (HemA) mice and dogs. The extension of rFVIIIFc half-life requires interaction of Fc with the neonatal Fc receptor (FcRn). In FcRn knockout mice, the extension of rFVIIIFc half-life is abrogated, and is restored in human FcRn transgenic mice. The Fc fusion has no impact on FVIII-specific activity. rFVIIIFc has comparable acute efficacy as rFVIII in treating tail clip injury in HemA mice, and fully corrects whole blood clotting time (WBCT) in HemA dogs immediately after dosing. Furthermore, consistent with prolonged half-life, rFVIIIFc shows 2-fold longer prophylactic efficacy in protecting HemA mice from tail vein transection bleeding induced 24-48 hours after dosing. In HemA dogs, rFVIIIFc also sustains partial correction of WBCT 1.5- to 2-fold longer than rFVIII. rFVIIIFc was well tolerated in both species. Thus, the rescue of FVIII by Fc fusion to provide prolonged protection presents a novel pathway for FVIII catabolism, and warrants further investigation. PMID:22246033

  6. Vertical Bridgman growth of thermoelectric clathrate Ba8Ga16Sn30 with a type-VIII structure

    Science.gov (United States)

    Chen, Y. X.; Niitani, K.; Izumi, J.; Suekuni, K.; Takabatake, T.

    2014-09-01

    Type-VIII clathrate Ba8Ga16Sn30 (BGS) is a promising thermoelectric material with tunable carrier types. We have studied the Bridgman growth conditions by combining differential thermal analysis (DTA) and powder X-ray diffraction analysis. It is found that the raw elements Ba, Ga, and Sn react at 465 °C to form the type-VIII BGS compound. The DTA indicates the presence of a liquidus line above the peritectic point of BGS at 495 °C. By using the vertical Bridgman method, single crystals of n-type and p-type BGS have been grown from Sn-rich and Ga-rich initial compositions, respectively. The obtained crystals of n-type Ba8Ga16Sn30 and p-type Ba8Ga16Sn30-xGex (x≈0.7) are 10 mm sized. On several parts cut from the grown crystals, the Seebeck coefficient and electrical resistivity have been measured up to 330 °C. The values weakly change along the vertical direction of the crystals, keeping the thermoelectric power factors as high as 12 and 9 μW/K2 cm, respectively, for n- and p-type crystals.

  7. Il ruolo di El Escorial, V.III.6 e dei suoi discendenti nella tradizione manoscritta del Lucullus

    Directory of Open Access Journals (Sweden)

    Corinna Senore

    2017-05-01

    Full Text Available L’articolo riguarda un gruppo di sette codici che tramanda il testo del Lucullus di Cicerone e che appartiene al ramo della tradizione discendente dal manoscritto Wien, Österreichische Nationalbibliothek 189. I sette manoscritti costituiscono uno stadio della tradizione caratterizzato dalla presenza di tre lacune testuali. Sulla base di alcuni elementi paleografici e della presenza di una glossa riportata a margine del testo di uno di essi, El Escorial, V.III.6 (Scor4, e inglobata all’interno del testo degli altri sei, è possibile individuare in Scor4 il capostipite di questo gruppo della tradizione. Lo studio si occupa inoltre di fare chiarezza sui rapporti che intercorrono tra i sei discendenti di Scor4. The article focuses on a group of seven codices which carry the text of Cicero’s Lucullus. This group belongs to the branch of the tradition descending from the manuscript Wien, Österreichische Nationalbibliothek 189. The seven manuscripts represent a step of the tradition marked by the presence of some textual lacunas. I start from some paleographic elements and from the presence of a gloss on text’s margin of one of them, El Escorial, V.III.6 (Scor4. The gloss has been then incorporated in the text of the other six manuscripts and I assume that Scor4 is the founder of this group of tradition. Furthermore, this article aims to clarify the relations between the six descendants of Scor4.

  8. MENINGKATKAN KETRAMPILAN MEMBUAT DAN MEMBACA KURVE KESEIMBANGAN SERTA HASIL BELAJAR SISWA MENGGUNAKAN METODE DISCOVERY DENGAN MENGGUNAKAN MEDIA VISUAL PADA SISWA KELAS VIII C SMP MUHAMMADIYAH 1 KUDUS

    Directory of Open Access Journals (Sweden)

    Desi Riana Prihandika

    2014-11-01

    Full Text Available Dari observasi awal yang dilakukan di SMP Muhammadiyah 1 Kudus, Pada mata pelajaran IPS khususnya pada materi kurve keseimbangan kurang variatif yaitu hanya ceramah tanpa variasi. Sedangkan materi yang diajarkan adalah aplikatif yaitu menuntut adanya keterampilan dari siswa.Untuk meningkatkan keterampilan siswa membuatdanmembacakurvekeseimbangan maka dilakukan penelitian tindakan kelas dengan Metode Discovery. Subjek penelitian ini adalah siswa kelas VIII C SMP Muhammadiyah 1 Kudus. Prosedur penelitian ini merupakan proses pembelajaran yang terdiri dari 2 siklus, dimana setiap siklus meliputi perencanaan, pelaksanaan tindakan, observasi dan refleksi. Instrumen yang digunakan yaitu lembar observasi dan test keterampilan. Hasil penelitian ini diperoleh presentase keterampilan siswa pada pembelajaran siklus I dengan kategori baik dan pada siklus II meningkat menjadi dengan kategori amat baik, persentase aktivitas guru pada pembelajaran siklus I dengan kategori amat baik dan pada siklus II meningkat menjadi dengan kategori amat baik, Berdasarkan hasil penelitian di atas dapat diambil kesimpulan bahwa, adanya peningkatan keterampilan siswa membuatdanmembacakurvekeseimbangankelas VIII C. From the first observation done in Muhammadiyah 1 Junior High School Kudus, gained information based on the interview result with the teacher of Social Studies grade VIII. Indeed, learning method that usually used are still conventional on Social Studies especially in equilibrium curve lesson is less variativethat is only speech without variants. Whereas the lessons taught are applicative that is demand skill existence for the students. The lesson that felt hard to understand to students are generally the lesson on making equilibrium curve and on reading curve mostly students still don’t understand the meaning of that curve. This is strengthened by average value on equilibrium cost lesson especially equilibrium curve on the VIII grade classified to quite low if

  9. Pisanello’s hat. The costume and weapons depicted in Pisanello’s medal for John VIII Palaeologus. A discussion of the saber and related weapons

    Directory of Open Access Journals (Sweden)

    Alexander, David

    2004-12-01

    Full Text Available A group of six drawings by the Veronese artist Antonio Pisano depicted the Bizantine Emperor John VIII Paleologus wearing costumes and weapons according to islamic types. This paper studies these objects in relation to other contemporary islamic weapons.

    Un grupo de seis dibujos del artista veronés Antonio Pisano representa al emperador bizantino Juan VIII Paleólogo vestido y armado según modelos islámicos. Este trabajo estudia dichos objetos en relación a otras armas islámicas contemporáneas.

  10. Les reconstructions de la vie de Jésus-Christ en aire maya

    OpenAIRE

    Colazo-Simon, Antonia; Geslin, Stéphanie; Reyes, Éric; Le Guen, Olivier

    2011-01-01

    Les histoires mayas de Jésus-Christ Les recueils de tradition orale maya enregistrent au fil des terrains l’occurrence de l’histoire de Jésus-Christ dans plusieurs ethnies mayas, à différents moments du xxe siècle, et sous des formes stylistiques distinctes. L’aspect le plus frappant de ces versions est la pluralité des noms concurrents que porte Jésus-Christ selon le lieu de recueil : si Jesukristo est employé chez les Yucatèques, les Tzeltal, les Tzotzil, les K’iche’, les Mam ou encore les ...

  11. Les reconstructions de la vie de Jésus-Christ en aire maya

    Directory of Open Access Journals (Sweden)

    Stéphanie Geslin

    2007-06-01

    Full Text Available Les histoires mayas de Jésus-Christ Les recueils de tradition orale maya enregistrent au fil des terrains l’occurrence de l’histoire de Jésus-Christ dans plusieurs ethnies mayas, à différents moments du xxe siècle, et sous des formes stylistiques distinctes. L’aspect le plus frappant de ces versions est la pluralité des noms concurrents que porte Jésus-Christ selon le lieu de recueil : si Jesukristo est employé chez les Yucatèques, les Tzeltal, les Tzotzil, les K’iche’, les Mam ou encore les ...

  12. Saturno devora a sus hijos. Miradas críticas sobre el desarrollo y sus promesas (Víctor Bretón Solo de Zaldivar

    Directory of Open Access Journals (Sweden)

    Ana Toledo Chávarri

    2011-05-01

    Full Text Available Saturno devora a sus hijos. Miradas críticas sobre el desarrollo y sus promesas es una compilación de artículos que actualiza el análisis antropológico sobre las prácticas y discursos del desarrollo. La participación de la antropología en el desarrollo tiene un muy largo recorrido que ha estado dominado desde la década de los noventa por una visión postestructuralista. Esta perspectiva constituye también el punto de partida de este libro.

  13. Antisense suppression of cucumber (Cucumis sativus L.) sucrose synthase 3 (CsSUS3) reduces hypoxic stress tolerance.

    Science.gov (United States)

    Wang, Hongyun; Sui, Xiaolei; Guo, Jinju; Wang, Zhenyu; Cheng, Jintao; Ma, Si; Li, Xiang; Zhang, Zhenxian

    2014-03-01

    Sucrose synthase (SUS; EC 2.4.1.13) plays important roles in sugar metabolism and abiotic stress response. But the genes encoding SUS in cucumber (Cucumis sativus L.) have not been well studied. Here, we isolated four cucumber sucrose synthase genes (CsSUS). Among them, CsSUS3, which highly expressed in the roots, was chosen for further study. Immunolocalization and subcellular localization analysis indicated that CsSUS3 localized in the cytosol and the plasma membrane, and mainly existed in the companion cells of phloem in the roots. When suffering hypoxia stress from flooding, CsSUS3 expression and SUS activity in roots increased, especially in the lateral roots; moreover, the soluble SUS activity increased clearly, but the membrane fraction hardly changed. Compared with the wild-type cucumbers, the transgenic lines with antisense expression of CsSUS3 were more sensitive to flooding. After 6 d of flooding, the SUS activity, soluble sugar and uridine 5'-diphosphate glucose (UDPG) content and the ratio of ATP/ADP in the roots of transgenic plants were significantly lower than that in wild-type plants. Moreover, the transgenic lines grew more slowly with more yellow necrosis in the leaves. These findings suggested CsSUS3 participated in resisting hypoxic stress. Furthermore, the mechanism of CsSUS3 in resisting hypoxic stress was also discussed. © 2013 John Wiley & Sons Ltd.

  14. Aliança da enfermagem com o usuário na defesa do SUS Alianza de la enfermería con el usuario en la defensa del SUS Nursing partnership with users in the defense of SUS

    Directory of Open Access Journals (Sweden)

    Carla Aparecida Arena Ventura

    2012-12-01

    Full Text Available Estudo reflexivo com o objetivo de apresentar, na perspectiva dos direitos humanos, elementos relevantes para o cuidado de enfermagem na defesa dos sujeitos no contexto do Sistema Único de Saúde (SUS brasileiro. A saúde como um direito de todos e um dever do Estado materializou-se como uma conquista da população com o SUS, com os princípios de universalidade, integralidade e equidade da atenção em saúde, ampliando a concepção de saúde para além da ausência de doença e passando a ser entendida como qualidade de vida. O enfermeiro tem grande potencial para desempenhar um papel singular na defesa do direito à saúde e do direito à vida e, por meio de alianças, fortalecer o exercício da cidadania das pessoas.Estudio reflexivo con el objetivo de presentar, en la perspectiva de los derechos humanos, elementos relevantes para el cuidado de enfermería en la defensa de los sujetos en el contexto del Sistema Único de Salud (SUS brasileño. La salud como un derecho de todos y un deber del Estado se ha consolidado como una conquista de la población con él SUS, con los principios de universalidad, integralidad y equidad de atención en salud, ampliando la concepción de salud para además de ausencia de enfermedades y que pasó a ser comprendida como calidad de vida. El enfermero tiene grande potencial para desarrollar un rol singular en la defensa del derecho a salud y del derecho a vida y, por medio de alianzas, fortalecer el ejercicio de la ciudadanía de las personas.This reflexive study aimed at presenting, based on the human rights framework, relevant elements for nursing care in the defense of the users of the Brazilian Single Health System (SUS. The assurance of health as a fundamental right and a government´s responsibility was an achievement of the population through SUS, founded on the principles of universal, integral and equitable care, expanding the conception of health beyond the idea of the lack of disease, understood

  15. Evolution of three cases of sarcomas of the sus-clavicular area after mammary radiotherapy

    International Nuclear Information System (INIS)

    Renard-Oldrini, S.; Marchal, C.; Verhaeghe, J.L.; El Hajj, L.; Beckendorf, V.; Tournier-Rangeard, L.; Peiffert, D.

    2010-01-01

    The authors comment the evolution observed for three cases of sarcomas in a previously irradiated sus-clavicular area. The three patients initially presented different cancers before the appearance of this sarcoma. The authors outline the exceptional characteristic of these sarcomas for their location in the sus-clavicular ganglionary area. Treatment is difficult. The authors suspect the existence of a genetic fragility. Short communication

  16. JOVENES ESTUDIANTES SECUNDARIOS Y SUS PROCESOS DE CONSTRUCCION DE (DES) CONFIANZA EN LOS OTROS

    OpenAIRE

    FARIAS OLMEDO; PABLO; FARIAS OLMEDO; PABLO

    2008-01-01

    La confianza representa el sustento lógico de toda sociedad, debido a que su presencia en las relaciones interpersonales significa su hilo conductor y el comienzo de una infinidad de redes entre individuos que sustentan sus acciones sobre la seguridad que les entregan tanto aquellos que los rodean, como las instituciones que los resguardan y socializan así como las estructuras que los gobiernan y determinan el curso de sus vidas. La globalización, materializada en nuev...

  17. Proteja a sus seres queridos de las caídas

    Centers for Disease Control (CDC) Podcasts

    2008-12-10

    Este podcast, que forma parte de la iniciativa Proteja a sus seres queridos, aborda las medidas que pueden tomar los padres de familia para ayudar a proteger a sus niños de las caídas, una de las principales causas de lesiones infantiles.  Created: 12/10/2008 by National Center for Injury Prevention and Control (NCIPC).   Date Released: 4/1/2009.

  18. Analisis Deskriptif Soal Geometri dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama Kelas VIII Berdasarkan Kriteria International Assessment TIMSS 2007

    Directory of Open Access Journals (Sweden)

    Etik Rahayu

    2012-06-01

    Full Text Available Tujuan penelitian ini adalah untuk mendeskripsikan  domain kognitif dan aspek kognitif (required behavior soal matematika dalam Buku Matematika Bilingual untuk Sekolah Menengah Pertama (SMP Kelas VIII berdasarkan kriteria International Assessment TIMSS 2007 dan proporsinya. Metode penelitian yang digunakan adalah deskriptif kualitatif, dengan subjek penelitian adalah soal geometri dalam Buku Matematika Bilingual SMP. yang berjudul “Mathematics for Junior High School Grade VIII 1st Semester” dan “Mathematics for Junior High School Grade VIII 2nd Semester” karangan karangan M. Cholik Adinawan dan Sugijono. Pengumpulan data menggunakan metode observasi dan wawancara tentang penggunaan buku matematika bilingual yang paling banyak digunakan di kota semarang. Pedoman analisis soal berdasarkan kriteria International Assessment TIMSS 2007, dengan validasi hasil oleh ahli. Hasil penelitian menunjukkan bahwa soal yang dianalisis memuat satu hingga tujuh aspek kognitif. Sebagian besar soal memuat 4 aspek kognitif yaitu 44.04 %, diikuti soal dengan 3 aspek kognitif  yaitu 36, 42%,  soal dengan 2 aspek kognitif yaitu 14, 90%, kemudian 1,99% untuk soal dengan 1 atau 5 aspek kognitif, dan 0,33% untuk soal dengan 6 atau 7 aspek kognitif. Proporsi tinggi pada recall (28.26% dan compute (26.57%, diikuti dengan SRP (10.85%, implement (10.65%, retrieve (8.36%, recognize (6.17%, analyze (1.99%, measure (1.59%, generalize (1.09%, SNRP (1.00%, classify (0.80%, represent (0.80%, justify (0.80%, select (0.60%, model (0.30%, synthesis (0.20%. Secara keseluruhan berdasarkan International Assessment TIMSS 2007 soal yang termasuk domain knowing memiliki persentase paling tinggi (52.28%, domain knowing-applying (24.83%, domain knowing- reasoning (12.91%, dan hanya sedikit yang termasuk domain knowing-apllying-reasoning (3.97%. Serta terdapat 4 soal (1.32% yang mempunyai ketidaksesuaian penggunaan mathematics terms serta 1 soal (0

  19. Recurrent myocardial infarctions in a young football player secondary to thrombophilia, associated with elevated factor VIII activity

    Directory of Open Access Journals (Sweden)

    Vacek TP

    2014-10-01

    Full Text Available Thomas P Vacek, Shipeng Yu, Shahnaz Rehman, Blair P Grubb, Daniel Kosinski, Cherian Verghese, Ehab A Eltahawy, Shafiq Qaiser Department of Medicine, University of Toledo Medical Center, Toledo, OH, USAAbstract: Myocardial infarction (MI due to coronary atherosclerosis in young adults is uncommon; rare causes such as cocaine abuse, arterial dissection, and thromboembolism should be considered. A 21-year-old football player, and otherwise healthy African American man, developed chest pain during exercise while bench-pressing 400 lbs. Acute MI was diagnosed based on physical examination, electrocardiography findings, and elevated cardiac enzymes. Coronary arteriography showed a thrombus occluding the proximal left anterior descending artery (LAD. Aggressive antiplatelet therapy with aspirin, clopidogrel, and eptifibatide was pursued, in addition to standard post-MI care. This led to the successful resolution of symptoms and dissolution of the thrombus, demonstrated by repeat coronary arteriography. Five months later, he presented with similar symptoms during exercise after lifting heavy weights, and was found to have another acute MI. Coronary arteriography again showed a thrombus occluding the LAD. No evidence of coronary artery dissection or vasospasm was found. Only mild atherosclerotic plaque burden was observed on both occasions by intravascular ultrasound. A bare metal stent was placed at the site as it was thought this site had acted as a nidus for small plaque rupture and thrombus formation. Elevated serum factor VIII activity at 205% (reference range 60%–140% was found, a rare cause of hypercoagulability. Further workup revealed a patent foramen ovale during a Valsalva maneuver by transesophageal echocardiography. Both events occurred during weight lifting, which can transiently increase right heart pressure in a similar way to the Valsalva maneuver. In light of all the findings, we concluded that an exercise-related increase in factor

  20. Estudios de impacto ambiental y sus tendencias en Colombia

    Directory of Open Access Journals (Sweden)

    Hernández Luis Alfredo

    1994-12-01

    nueva Constitución de la República y el Decreto Ley 99 de 1993 (Creación del Ministerio del

    Medio Ambiente, promulgan que los EIA incluyan lo referente a deberes y derechos ciudadanos y los Fundamentos de Política Ambiental, respectivamente. En forma general, se destaca la importancia y contenido de los EIA en cualquier acción antrópica tendiente a intervenir o modificar los componentes ambientales y sus relaciones entre sí, se incorporan los costos ambientales y se exigen a los proyectos alternativas técnicas tendientes a ejecutar aquéllos de menor efecto ambiental, así sean los más costosos. Además, permiten una ingerencia más decisiva de la administración territorial y/o corporativa en proyectos de desarrollo; se destaca el papel de la Procuraduría, Contraloría y Defensoría del pueblo en el control y reposición ambiental y, sobre todo, la participación ciudadana o gremial en la decisión del otorgamiento de licencias ambientales. Otro aspecto importante lo constituye la planificación ambiental del país, como base el ordenamiento territorial.

  1. El anisakis y sus enfermedades como enfermedad profesional

    Directory of Open Access Journals (Sweden)

    José Manuel Vicente Pardo

    , elaboración o preparación del pescado contaminado. Describimos en este artículo las enfermedades por anisakis, los trabajos de riesgo, las características que debieran reunir para ser enfermedad profesional y dos casos ilustrativos cuya consideración lo fue como esta contingencia laboral. Conclusión: Las enfermedades por anisakis y su consideración como enfermedad profesional, viene sujeta a la propia definición de lo que se considera así en nuestra norma legal, es decir que sea una enfermedad contraída como consecuencia del trabajo, en las actividades que se describen en el cuadro de enfermedades profesionales y por la acción del agente o sus sustancias que se recogen en el anexo I del actual cuadro. Además para que se admita como enfermedad profesional debemos de tener un diagnóstico firme (encuadrado en el cuadro de enfermedad profesional, un agente causal (recogido en el listado y una exposición al anisakis desarrollada en el ejercicio del trabajo (actividades recogidas en el listado. El listado o cuadro de enfermedad profesional es un sistema cerrado para agentes causales y enfermedades causadas, y la adscripción no es fácil. La parasitación tendría cabida en el grupo de enfermedades por agentes biológicos, la alergia podría discutirse su adscripción pero suele recogerse también en este grupo, el asma lo recogeríamos en el grupo de enfermedades respiratorias (causadas por inhalación dice el texto legal y las manifestaciones dérmicas en el grupo de las enfermedades profesionales de la piel. La exposición laboral al anisakis, es necesaria e imprescindible para que el proceso sea calificado de enfermedad profesional, pero esta exposición no siempre estará bien delimitada, y sin embargo debe estar probada. Puede haber existido una sensibilización fuera del trabajo y una aparición o desarrollo de la enfermedad por reiterada exposición o contacto con el anisakis en el trabajo lo que dificultará su calificación ocupacional.

  2. Comparative analysis of activity of coagulation Factors V and VIII and level of fibrinogen in fresh frozen plasma and frozen plasma

    Directory of Open Access Journals (Sweden)

    Mitu Dogra

    2015-01-01

    Full Text Available Background: The aim of this study was to analyse and compare the activity of factor V, VIII and fibrinogen level in fresh frozen plasma and frozen plasma frozen after 8 hrs but within 24 hours after phlebotomy. Materials and Methods: Fresh frozen plasma separated from whole blood within 8 hours was compared with plasma separated within 24 hours after phlebotomy in terms of coagulation factors V and VIII and level of fibrinogen by standard methods using semi automated coagulometer sysmex CA50. Results: Longer storage of whole blood before processing resulted in significant decrease (18.4% in activity of factor VIII but the fall in activity of factor V (6.52% or level of fibrinogen (1.81% was not significant. Discussion: These data suggest that there is good retention of coagulation factors in both types of plasma. Although there is significant fall in activity of factor VIII, but it is an acute phase reactant and raised in most of the diseases so it is suggested that frozen plasma would be an acceptable product for most patients requiring fresh frozen plasma.

  3. High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

    OpenAIRE

    Nguyen, Phuong-Cac T.; Lewis, Kenneth B.; Ettinger, Ruth A.; Schuman, Jason T.; Lin, Jasper C.; Healey, John F.; Meeks, Shannon L.; Lollar, Pete; Pratt, Kathleen P.

    2014-01-01

    Amino acid residues comprising B-cell epitopes recognized by neutralizing anti-factor VIII antibodies (inhibitors) have been identified.Amino acids contributing significant antigen–antibody binding avidity are candidates for mutagenesis in the design of less antigenic proteins.

  4. Hemophilia as a defect of the tissue factor pathway of blood coagulation: Effect of factors VIII and IX on factor X activation in a continuous-flow reactor

    International Nuclear Information System (INIS)

    Repke, D.; Gemmell, C.H.; Guha, A.; Turitto, V.T.; Nemerson, Y.; Broze, G.J. Jr.

    1990-01-01

    The effect of factors VIII and IX on the ability of the tissue factor-factor VIIa complex to activate factor X was studied in a continuous-flow tubular enzyme reactor. Tissue factor immobilized in a phospholipid bilayer on the inner surface of the tube was exposed to a perfusate containing factors VIIa, VIII, IX, and X flowing at a wall shear rate of 57, 300, or 1130 sec -1 . The addition of factors VIII and IX at their respective plasma concentrations resulted in a further 2 endash-to 3 endash fold increase. The direct activation of factor X by tissue factor-factor VIIa could be virtually eliminated by the lipoprotein-associated coagulation inhibitor. These results suggest that the tissue factor pathway, mediated through factors VIII and IX, produces significant levels of factor Xa even in the presence of an inhibitor of the tissue factor-factor VIIa complex; moreover, the activation is dependent on local shear conditions. These findings are consistent both with a model of blood coagulation in which initiation of the system results from tissue factor and with the bleeding observed in hemophilia

  5. Retsensioon : Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare. Peatoimetaja Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. 326 lk. / Mart Nutt

    Index Scriptorium Estoniae

    Nutt, Mart, 1962-

    2004-01-01

    Arvustus: Riigikogu VII, VIII ja IX koosseis. Statistikat ja kommentaare / peatoim. Aaro Mõttus. Tallinn : Riigikogu Kantselei, Eesti Rahvusraamatukogu, 2004. - Lisatud: Ott Heinapuu tutvustav sõnum retsenseeritud väljaande kohta lk. 193. - Vt. ka: http://www.riigikogu.ee/rito/index.php?id=11357

  6. Reticular Basement Membrane Vessels Are Increased in COPD Bronchial Mucosa by Both Factor VIII and Collagen IV Immunostaining and Are Hyperpermeable

    Directory of Open Access Journals (Sweden)

    Amir Soltani

    2012-01-01

    Full Text Available Background and Objective. Using Collagen IV staining, we have previously reported that the reticular basement membrane (Rbm is hypervascular and the lamina propria (LP is hypovascular in COPD airways. This study compared Collagen IV staining with vessels marked with anti-Factor VIII and examined vessel permeability in bronchial biopsies from COPD and normal subjects using albumin staining. Results. Anti-Collagen IV antibody detected more vessels in the Rbm (P=0.002 and larger vessels in both Rbm (P<0.001 and LP (P=0.003 compared to Factor VIII. COPD airways had more vessels (with greater permeability in the Rbm (P=0.01 and fewer vessels (with normal permeability in the LP compared to controls with both Collagen IV and Factor VIII antibodies (P=0.04 and P=0.01. Conclusion. Rbm vessels were increased in number and were hyperpermeable in COPD airways. Anti-Collagen IV and anti-Factor VIII antibodies did not uniformly detect the same vessel populations; the first is likely to reflect larger and older vessels with the latter reflecting smaller, younger vessels.

  7. Report on corrections and future considerations for Appendices II–VIII of the International Code of Nomenclature for Algae, Fungi, and Plants

    Science.gov (United States)

    For the first time, the main text and Appendices II–VIII of the International Code of Nomenclature were separately published following decisions of the Melbourne Nomenclature Section, which contributed to subsequent development of an online resource capable of producing the Appendices in real time. ...

  8. Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake

    NARCIS (Netherlands)

    Bloem, Esther; van den Biggelaar, Maartje; Wroblewska, Aleksandra; Voorberg, Jan; Faber, Johan H.; Kjalke, Marianne; Stennicke, Henning R.; Mertens, Koen; Meijer, Alexander B.

    2013-01-01

    The C1 domain of factor VIII (FVIII) has been implicated in binding to multiple constituents, including phospholipids, von Willebrand factor, and low-density lipoprotein receptor-related protein (LRP). We have previously described a human monoclonal antibody called KM33 that blocks these

  9. Identification of coagulation factor VIII A2 domain residues forming the binding epitope for low-density lipoprotein receptor-related protein.

    Science.gov (United States)

    Sarafanov, Andrey G; Makogonenko, Evgeny M; Pechik, Igor V; Radtke, Klaus-Peter; Khrenov, Alexey V; Ananyeva, Natalya M; Strickland, Dudley K; Saenko, Evgueni L

    2006-02-14

    Regulation of the coagulation factor VIII (fVIII) level in circulation involves a hepatic receptor low-density lipoprotein receptor-related protein (LRP). One of two major LRP binding sites in fVIII is located within the A2 domain (A2), likely exposed within the fVIII complex with von Willebrand factor and contributing to regulation of fVIII via LRP. This work aimed to identify A2 residues forming its LRP-binding site, previously shown to involve residues 484-509. Isolated A2 was subjected to alanine-scanning mutagenesis followed by expression of a set of mutants in a baculovirus system. In competition and surface plasmon resonance assays, affinities of A2 mutants K466A, R471A, R484A, S488A, R489A, R490A, H497A, and K499A for LRP were found to be decreased by 2-4-fold. This correlated with 1.3-1.5-fold decreases in the degree of LRP-mediated internalization of the mutants in cell culture. Combining these mutations into pairs led to cumulative effects, i.e., 7-13-fold decrease in affinity for LRP and 1.6-2.2-fold decrease in the degree of LRP-mediated internalization in cell culture. We conclude that the residues mentioned above play a key role in formation of the A2 binding epitope for LRP. Experiments in mice revealed an approximately 4.5 times shorter half-life for A2 in the circulation in comparison with that of fVIII. The half-lives of A2 mutant R471A/R484A or A2 co-injected with receptor-associated protein, a classical ligand of LRP, were prolonged by approximately 1.9 and approximately 3.5 times, respectively, compared to that of A2. This further confirms the importance of the mutated residues for interaction of A2 with LRP and suggests the existence of an LRP-dependent mechanism for removing A2 as a product of dissociation of activated fVIII from the circulation.

  10. Expressão citofotométrica dos marcadores tumorais CD-34 e fator VIII no câncer de cólon

    Directory of Open Access Journals (Sweden)

    Cacilda Joyce Ferreira da Silva Garcia

    Full Text Available OBJETIVOS: Verificar a posssibilidade de quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII no câncer de cólon; verificar se existe superioridade entre um marcador e outro para estudo da angiogênese; verificar se há correlação na análise do índice de marcagem e a densidade óptica média nos marcadores utilizados. MÉTODOS: Dezessete casos de adenocarcinoma colorretal recuperados de blocos de parafina e confirmados pela hematoxilina-eosina, foram submetidos à coloração imunoistoquímica pelo método da estreptoavidina-biotina-peroxidase e utilizados os marcadores tumorais CD-34 e Fator VIII. Após este processo as lâminas foram submetidas à leitura no sistema Samba 4000® e avaliadas pelo software Immuno®. Os parâmetros estudados foram: índice de marcagem e densidade óptica, expressos por médias, medianas, valores mínimos, valores máximos e desvios-padrão, analisados estatisticamente. RESULTADOS: Para o marcador CD-34 não houve normalidade dos dados em relação ao índice de marcagem e houve para a densidade óptica. Para o Fator VIII, houve normalidade de dados em relação ao índice de marcagem e para a densidade óptica. CONCLUSÃO: Foi possível quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII através do índice de marcagem e da densidade óptica média; não houve diferença entre os marcadores em relação à média do índice de marcagem e da densidade óptica, não sendo possível definir superioridade entre um e outro; não foi observada tendência à correlação quando comparados densidade óptica e índice de marcagem do Fator VIII e do CD-34 isoladamente estudados; não houve correlação entre o índice de marcagem do Fator VIII quando comparado com o CD-34, bem como a densidade óptica do Fator VIII com o CD-34.

  11. VIII Spanish meeting on statistical physics: Proceeding of the Meeting held at Universidad Carlos III de Madrid

    International Nuclear Information System (INIS)

    Cuesta, J.A.; Sanchez, A.

    1998-01-01

    This book contains the Proceedings of ''Fisica Estadistica'97'' (FisEs'97, VIII Spanish Meeting on Statistical Physics), held at the Campus of Getafe (Madrid, Spain) of the Universidad Carlos III de Madrid on September 25 through 27, 1997. Although this is the first time the Proceedings of a Meeting in this series are published, ''Fisica Estasdistica'' dates back to 1986, when about fifty Spanish scientists attended the first edition in Barcelona. That first Meeting was organized by a group of young and not so young physicists who wanted to set up a national conference of an international level and with a broader, more interdisciplinary scope than others held at that time. Their idea quickly got off the ground and following the first edition, sequels took place every year and a half: Palma de Mallorca (1988), Badajoz (1990), Cabuenas, Asturies (1991), El Escorial, Madrid (1993), Sevilla (1994), and Zaragoza (1996)

  12. Detailed Analysis of Configuration Interaction and Calculation of Radiative Transition Rates in Seven Times Ionized Tungsten (W VIII

    Directory of Open Access Journals (Sweden)

    Jérôme Deprince

    2015-06-01

    Full Text Available A new set of oscillator strengths and transition probabilities for EUV spectral lines of seven times ionized tungsten (W VIII is reported in the present paper. These results have been obtained using the pseudo-relativistic Hartree-Fock (HFR method combined with a semi-empirical optimization of the radial parameters minimizing the discrepancies between computed energy levels and available experimental data. The final physical model considered in the calculations has been chosen further to a detailed investigation of the configuration interaction in this atomic system characterized by complex configurations of the type 4f145s25p5, 4f145s25p4nl, 4f145s5p6, 4f135s25p6, 4f135s25p5nl and 4f125s25p6nl (nl = 5d, 6s.

  13. Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A

    DEFF Research Database (Denmark)

    Hvas, Anne-Mette; Sørensen, Hanne Thykjær; Norengaard, Lisbeth

    2007-01-01

    BACKGROUND: Most patients with severe hemophilia A suffer from a profoundly compromised hemostatic response. In addition to both the delayed and slow development of a clot, previous studies have documented that severe hemophilia A is also associated with reduced clot stability. OBJECTIVES: We...... examined whether the clot stability in hemophiliacs could be improved by treatment with tranexamic acid (TXA) in combination with recombinant factor VIII (rFVIII). PATIENTS/METHODS: Baseline blood samples were obtained from eight males with severe hemophilia A. Thereafter, a bolus injection of r...... the elasticity curve increased 5-fold after rFVIII and 24-fold after addition of TXA. CONCLUSIONS: The study demonstrates that simultaneous treatment with TXA and rFVIII significantly improves the clot stability in patients with hemophilia A. Udgivelsesdato: December...

  14. Proceedings of XIV Workshop on Nuclear Physics. VIII International Symposium on Nuclear and Related Techniques. WONP-NURT 2013

    International Nuclear Information System (INIS)

    2013-02-01

    This year 2013, the XIV Workshop on Nuclear Physics and VIII International Symposium on Nuclear and Related Techniques, WONP-NURT 2013 organized by the Center of Technological Applications and Nuclear Development from 5 to 8 February at the National Museum of Fine Arts. NURT is one of the key Cuban scientific meetings since 1997 dealing with the peaceful applications of nuclear techniques in several domains of the society. WONP and NURT provide an unique opportunity for the national and international scientific community to meet outstanding researchers and discuss current trends in several areas of theoretical, experimental and applied nuclear physics and related topics. The papers submitted to this event are presented in this CD-ROM

  15. Short-range order in alloys of nickel with the elements of group VIII of the periodic table

    International Nuclear Information System (INIS)

    Khwaja, F.A.

    1981-08-01

    Experimental measurements of the diffuse X-ray scattering intensity were performed on alloys of Ni with Rh and Os. The atomic short-range order (SRO) parameters αsub(i) and the size-effect parameters βsub(i) were calculated from these measurements. It is established that SRO and size-effect exist in Ni-Rh and Ni-Os alloys analogously as in a few other alloys of Ni with the elements of group VIII of the periodic table. The experimental data was interpreted theoretically by calculating the interaction energies from the pseudo-potentials and the effective valencies of the individual components of the systems studied. It was found that theoretically calculated values of the interaction energies for these alloys are inconsistent with the experimentally determined sign of the SRO parameter. (author)

  16. Late-Onset Invasive Group B Streptococcal Infection with Serotype VIII in a Neonate Having Congenital Biliary Atresia

    Directory of Open Access Journals (Sweden)

    Tomoaki Takei

    2013-02-01

    Full Text Available A female newborn was admitted to our department 15 days after birth for insufficient sucking and jaundice. The patient’s blood and urine cultures were both positive for group B streptococcal (GBS infection. A maternal vaginal sample at 35 weeks’ gestation was negative for GBS in culture-based microbiologic screening. The patient recovered shortly after receiving systemic antibiotic therapy. On the basis of clinical evidence of white stool and progressive jaundice, we suspected that the newborn had complications related to congenital biliary atresia (CBA; surgery was performed. Isolates from the mother’s vaginal sample obtained when the patient was 25 days old, along with neonatal blood, revealed identical patterns (serotype VIII and sequence type 1 of GBS capsular and multilocus sequence typing, suggestive of maternal transmission. Molecular epidemiologic examination may be useful to clarify the transmission route and etiology; culture-based microbiologic screening appears to have limitations for detecting the route of transmission.

  17. The B-domain of factor VIII reduces cell membrane attachement to host cells in serum free conditions

    DEFF Research Database (Denmark)

    Kolind, Mille Petersen; Nørby, Peder Lisby; Flintegaard, Thomas Veje

    2010-01-01

    binding of rFVIII to the cell membrane could be a factor diminishing the production yield. We studied the contribution of the rFVIII B-domain to membrane attachment by transfecting several constructs containing increasing lengths of the B-domain into cells under serum free conditions. We found that 90......Factor VIII (FVIII) is an important protein in the blood coagulation cascade and dysfunction or deficiency of FVIII causes haemophilia A. Replacement therapy with exogenous recombinant FVIII (rFVIII) works as a substitute for the missing or non-functioning FVIII. The rFVIII protein has been...... engineered extensively throughout the years to increase the low production yields that initially were obtained from mammalian cell cultures. The scope of this work was to investigate the interaction of rFVIII with the cell membrane surface of the producing cells in serum free medium. We wondered whether...

  18. Sobre el principio de la injusticia: la exclusión (VIII Conferencias Aranguren, 1999

    Directory of Open Access Journals (Sweden)

    Villoro, Luis

    2000-09-01

    Full Text Available Not Available

    Muchas teorías contemporáneas han intentado fundamentar una teoría de la justicia en alguna forma de consenso, sea fáctico o hipotético. Pero esa vía presenta muchas dificultades teóricas que la vuelven difícilmente aceptable. Un consenso posible podría fundarse en una voluntad ética desprendida de actitudes excluyentes y no a la inversa. Cabe pues explorar una alternativa: dar razón de la idea de justicia por la voluntad de disrupcion de una situación percibida como injusta. Eso es lo que ha acontecido históricamente y, así, la teoría de la justicia se remitiría a esa experiencia de hecho y partiría de su examen crítico. Procedería en dos partes. Primero, la caracterización de la injusticia cuyo principio es la exclusión. Ésta puede definirse como la no-pertenencia a una asociación civil dada, de personas que pertenecen a la comunidad de los hombres. La percepción de la exclusión nos llevaría a determinar tanto los requisitos de pertenencia a una asociación civil como las exigencias planteadas por compartir la condición humana. Segundo, el análisis de las principales formas de exclusión y sus modalidades. De ese análisis podrían deducirse los principios de una teoría de la justicia que partiera del rechazo de una situación de exclusión real, sea o no objeto de consenso.

  19. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice.

    Directory of Open Access Journals (Sweden)

    Marina E Fomin

    Full Text Available Liver sinusoidal endothelial cells (LSECs form a semi-permeable barrier between parenchymal hepatocytes and the blood. LSECs participate in liver metabolism, clearance of pathological agents, immunological responses, architectural maintenance of the liver and synthesis of growth factors and cytokines. LSECs also play an important role in coagulation through the synthesis of Factor VIII (FVIII. Herein, we phenotypically define human LSECs isolated from fetal liver using flow cytometry and immunofluorescence microscopy. Isolated LSECs were cultured and shown to express endothelial markers and markers specific for the LSEC lineage. LSECs were also shown to engraft the liver when human fetal liver cells were transplanted into immunodeficient mice with liver specific expression of the urokinase-type plasminogen activator (uPA transgene (uPA-NOG mice. Engrafted cells expressed human Factor VIII at levels approaching those found in human plasma. We also demonstrate engraftment of adult LSECs, as well as hepatocytes, transplanted into uPA-NOG mice. We propose that overexpression of uPA provides beneficial conditions for LSEC engraftment due to elevated expression of the angiogenic cytokine, vascular endothelial growth factor. This work provides a detailed characterization of human midgestation LSECs, thereby providing the means for their purification and culture based on their expression of CD14 and CD32 as well as a lack of CD45 expression. The uPA-NOG mouse is shown to be a permissive host for human LSECs and adult hepatocytes, but not fetal hepatoblasts. Thus, these mice provide a useful model system to study these cell types in vivo. Demonstration of human FVIII production by transplanted LSECs encourages further pursuit of LSEC transplantation as a cellular therapy for the treatment of hemophilia A.

  20. Targeting factor VIII expression to platelets for hemophilia A gene therapy does not induce an apparent thrombotic risk in mice.

    Science.gov (United States)

    Baumgartner, C K; Mattson, J G; Weiler, H; Shi, Q; Montgomery, R R

    2017-01-01

    Essentials Platelet-Factor (F) VIII gene therapy is a promising treatment in hemophilia A. This study aims to evaluate if platelet-FVIII expression would increase the risk for thrombosis. Targeting FVIII expression to platelets does not induce or elevate thrombosis risk. Platelets expressing FVIII are neither hyper-activated nor hyper-responsive. Background Targeting factor (F) VIII expression to platelets is a promising gene therapy approach for hemophilia A, and is successful even in the presence of inhibitors. It is well known that platelets play important roles not only in hemostasis, but also in thrombosis and inflammation. Objective To evaluate whether platelet-FVIII expression might increase thrombotic risk and thereby compromise the safety of this approach. Methods In this study, platelet-FVIII-expressing transgenic mice were examined either in steady-state conditions or under prothrombotic conditions induced by inflammation or the FV Leiden mutation. Native whole blood thrombin generation assay, rotational thromboelastometry analysis and ferric chloride-induced vessel injury were used to evaluate the hemostatic properties. Various parameters associated with thrombosis risk, including D-dimer, thrombin-antithrombin complexes, fibrinogen, tissue fibrin deposition, platelet activation status and activatability, and platelet-leukocyte aggregates, were assessed. Results We generated a new line of transgenic mice that expressed 30-fold higher levels of platelet-expressed FVIII than are therapeutically required to restore hemostasis in hemophilic mice. Under both steady-state conditions and prothrombotic conditions induced by lipopolysaccharide-mediated inflammation or the FV Leiden mutation, supratherapeutic levels of platelet-expressed FVIII did not appear to be thrombogenic. Furthermore, FVIII-expressing platelets were neither hyperactivated nor hyperactivatable upon agonist activation. Conclusion We conclude that, in mice, more than 30-fold higher levels of

  1. Characterization of a thrombin cleavage site mutation (Arg 1689 to Cys) in the factor VIII gene of two unrelated patients with cross-reacting material-positive hemophilia A.

    Science.gov (United States)

    Arai, M; Higuchi, M; Antonarakis, S E; Kazazian, H H; Phillips, J A; Janco, R L; Hoyer, L W

    1990-01-15

    The molecular defect responsible for moderate and severe hemophilia A has been identified for two unrelated patients with the CRM-positive form of this disorder (factor VIII activity of 0.02 and 0.05 U/mL with factor VIII antigen of 0.87 and 2.20 U/mL). In both cases, the immunopurified dysfunctional factor VIII protein is abnormal, in that the 80 Kd light chain is not cleaved by thrombin at arginine-1689. The basis for this failure was identified by polymerase chain reaction amplification of exon 14 of the variant factor VIII genes and direct sequencing of the amplified products. In both cases, a single base substitution (C to T) was identified that produces an arginine to cysteine substitution at amino acid residue 1689. These data identify the molecular defects of the two identical factor VIII variant proteins. The dysfunctional factor VIII has been designated "Factor VIII-East Hartford," the residence of the patient in whom the defect was first identified.

  2. O SUS nos seus 20 anos: reflexões num contexto de mudanças Twenty years of SUS: reflections in a context of changes

    Directory of Open Access Journals (Sweden)

    Georgia Costa de Araújo Souza

    2010-09-01

    Full Text Available A partir de uma breve retrospectiva sobre o direito à saúde conquistado pelo cidadão brasileiro, este artigo tem como objetivo discorrer sobre o Sistema Único de Saúde (SUS ao longo da sua trajetória de 20 anos, destacando em forma de análise crítica os avanços conquistados na saúde e os desafios a serem superados. São discutidas as temáticas do direito à saúde como responsabilidade do Estado a partir da Conferência de Alma-Ata, da Constituição Federal e das Leis Orgânicas da Saúde; as diretrizes do SUS envolvendo as competências da União, do Estado e do Município. Discute ainda a importância da Estratégia Saúde da Família na consolidação da Atenção Básica no Brasil, as dificuldades do processo de regionalização e o papel da gestão e da participação social como bases para a construção do SUS que queremos.From a brief review of the right to healthcare won by the Brazilian citizens, this article aims to discuss Sistema Único de Saúde (SUS - National Health System throughout its trajectory of 20 years, providing a critical review of the progress achieved in healthcare and the challenges to be overcome. It discusses the issues of: the right to healthcare as the State's responsibility based on the Alma-Ata Conference, the Federal Constitution and the Organic Laws on Health; SUS guidelines involving the competences of the Union, States and Municipalities. It also approaches the importance of the Family Health Strategy for the consolidation of Primary Care in Brazil, the difficulties in the process of regional health planning, and the role of management and social participation as the bases for the construction of the SUS we want.

  3. Pengaruh Model Pembelajaran Colek Pipi (Cooperative Learning Ko Picture and Picture) Terhadap Motivasi Dan Hasil Belajar IPA Peserta Didik Kelas VIII SMP Muhammadiyah Rambah Kabupaten Rokan Hulu Tahun Pembelajaran 2014/2015

    OpenAIRE

    Nasution, Sri Hariyanti; Lestari, Rena; -, Dahlia

    2015-01-01

    The aim of the study was to determine the effect of learning model COLEK PIPI (Cooperative Learning KoPicture and Picture) approach about motivation and the results of SAINS students class VIII SMPMuhammadiyah Rambah Rokan Hulu in Academic Year 2014/2015. This study used quasi-experimental. Thesample of study was VIII-1 class experimen and VIII-2 class control. The result of the study showed that themeans persent of learning motivation of quastiionnaire data was 78,56 with high criteria. The ...

  4. Perception of health’s academics about the unified health system (SUS

    Directory of Open Access Journals (Sweden)

    Pâmela Billig Mello

    2012-01-01

    Full Text Available The aim of this study was to investigate the perceptions of health’s students of University of Cruz Alta -RS about the Brazilian Health Public System (SUS. The sample consisted of one hundred and sixteen students, most between 18 and 20 years (53% who answered a questionnaire with open and closed questions. Among the main results we verified that: 60.8% of students do not have private health plan, being dependent of SUS, the majority (87.9% identified the SUS as a set of actions and free health services, but other students do confusion between SUS and the brazilian social security system, 27.1% see the SUS as a system focused on low-income people, 95.2% had never attended a meeting of the Municipal Council Health and 44% believe that those who exercise SUS’s social control is the government. We verified realized difficulty that students have to define and insert into your professional practice important concepts of public health; we verify, thus, the importance of implementation of public policies that involve higher education institutions and enable the transformation of these ideas.

  5. An evaluation of designed Start-up System (SUS) for once-through steam generators

    International Nuclear Information System (INIS)

    Yu, Dali; Peng, Minjun; Xia, Genglei; Mao, Wanchao; Yang, Yang

    2014-01-01

    Highlights: • Four SUS solutions are established to help reactors complete the start-up process. • Solutions C and D lead to superior behaved than Solutions A and B. • Solution C is fit for propulsion reactors and Solution D for nuclear power reactors. - Abstract: In this paper, we report on research that has been carried out both on the comparison and evaluation of four designed Start-up Systems (SUSs), which are proposed to improve reliability and economy during the reactor start-up process. Firstly, four SUS solutions are established to satisfy demands and detailed descriptions are introduced. Then, four reactor systems, which include SUS, are modeled by the estimate code JTopmeret. Furthermore besides, the JTopmeret code is validated for the once-through steam generators (OTSG). Finally, the behaviors of SUS and the steady and transient performance of OTSG are investigated. The results show that the designed SUS can successfully improve the economy and the OTSG operational safety. Suggestion is made in this paper to apply Solution C in propulsion-purposed reactors, and Solution D in nuclear power reactors

  6. Weldability of dissimilar joint between F82H and SUS316L under fiber laser welding

    Energy Technology Data Exchange (ETDEWEB)

    Serizawa, Hisashi [Joining and Welding Research Institute, Osaka University, 11-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Mori, Daiki; Shirai, Yuma; Ogiwara, Hiroyuki; Mori, Hiroaki [Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan)

    2013-10-15

    Highlights: • The microstructure of F82H/SUS316L dissimilar joint can be divided into four regions. • In the case without beam position shift, hardness of WM cannot be reduced by PWHT. • The fiber laser welding would be applicable for constructing the dissimilar joint. -- Abstract: As one of the high beam quality heat sources, 4 kW fiber laser was applied for joining between reduced activation ferritic/martensitic steel, F82H and SUS316L austenitic stainless steel, and the microstructural analyses and Vickers hardness measurements were carried out before and after post-weld heat treatment (PWHT). The microstructure of joint can be divided into four regions which are base metal of F82H, heat affected zone (HAZ) in F82H, weld metal (WM) and base metal of SUS316L. Also, it is revealed that the high-power fiber laser can be employed for constructing butt joint between F82H and SUS316L by applying PWHT and shifting the laser beam position to SUS316L, where the distance between the contact face and beam should be set as a range from radius to diameter of laser beam.

  7. La labor preventiva en la familia de alumnos que no cumplen con sus deberes escolares

    Directory of Open Access Journals (Sweden)

    Deyanira de la Cruz-García

    2017-11-01

    Full Text Available En la sociedad cubana, la educación de la familia es uno de los modos de formación de la joven generación. De ello se infiere que el trabajo a realizar con los padres es muy importante, en especial con los que tienen hijos en edades tempranas y preescolares, donde se hace sentir con mayor fuerza la influencia de la acción modeladora en la conducta y sus relaciones con la vida. Este artículo tiene como propósito orientar a las familias de menores que no cumplen con sus deberes escolares, acerca de las vías que pueden ser utilizadas para perfeccionar la educación que ejercen en sus hijos.

  8. Defect structures in nickel and SUS304SS formed by the collapse of cavitation bubbles

    Energy Technology Data Exchange (ETDEWEB)

    Yoshiie, T., E-mail: yoshiie@rri.kyoto-u.ac.j [Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka-fu 590-0494 (Japan); Sato, K.; Xu, Q. [Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka-fu 590-0494 (Japan); Komatsu, M. [Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka-fu 590-0494 (Japan); Hiroshima Institute of Technology, Saeki-ku, Hiroshima-ken 731-5193 (Japan); Futakawa, M.; Naoe, T. [Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka-fu 590-0494 (Japan); J-PARC Center, Japan Atomic Energy Agency, Tokai-mura, Ibaraki-ken 319-1195 (Japan); Kawai, M. [Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka-fu 590-0494 (Japan); High Energy Accelerator Research Organization, Oho, Tsukuba-shi, Ibaraki-ken 305-0801 (Japan)

    2010-03-15

    A mercury target in high-power spallation neutron sources is subjected to pressure waves induced by a proton beam. The subsequent formation and collapse of cavitation bubbles lead to cavitation damage on the target vessel, especially the beam window. The cavitation damage in Ni and austenitic stainless steel SUS304SS were studied by using an electro-Magnetic IMpact Testing Machine (MIMTM) developed to simulate the damage. The existence of dislocations, stacking fault tetrahedra and vacancies was detected by positron annihilation lifetime measurements in Ni, and non-cellular dislocation structures were observed by transmission electron microscopy in Ni and SUS304SS. In addition, a high density of twins was observed in SUS304SS. These results were compared with those of high-speed compression tests using a high-speed projectile, proving that the cavitation damage caused by MIMTM corresponded to high-speed deformation.

  9. IDENTIFICATION AND CHARACTERIZATION OF THE SUCROSE SYNTHASE 2 GENE (Sus2 IN DURUM WHEAT

    Directory of Open Access Journals (Sweden)

    Mariateresa eVolpicella

    2016-03-01

    Full Text Available Sucrose transport is the central system for the allocation of carbon resources in vascular plants. Sucrose synthase, which reversibly catalyzes sucrose synthesis and cleavage, represents a key enzyme in the control of the flow of carbon into starch biosynthesis. In the present study the genomic identification and characterization of the Sus2-2A and Sus2-2B genes coding for sucrose synthase in durum wheat (cultivars Ciccio and Svevo is reported. The genes were analyzed for their expression in different tissues and at different seed maturation stages, in four tetraploid wheat genotypes (Svevo, Ciccio, Primadur and 5-BIL42. The activity of the encoded proteins was evaluated by specific activity assays on endosperm extracts and their structure established by modelling approaches. The combined results of SUS2 expression and activity levels were then considered in the light of their possible involvement in starch yield.

  10. Hijos adultos mayores al cuidado de sus padres, un fenómeno reciente

    Directory of Open Access Journals (Sweden)

    P. Beatriz Zegers, PS.

    2012-01-01

    Full Text Available Es un hecho inédito en la historia de la humanidad que hijos que han llegado a la ancianidad cuiden de sus padres. Se mostrarán las particulares vicisitudes y desafíos que se plantean en el seno de la familia extensa cuando se trata de hijos adultos mayores quienes asumen la tarea de cuidar a sus padres, ya que éstas difieren de aquellas que se formulan cuando los hijos se encuentran en la adultez media. Si bien muchas familias se adaptan sin grandes sobresaltos a esta transición biográfica, otras se enfrentan a auténticas crisis. Distinguirlas puede ayudar a los profesionales de salud a manejar de mejor modo a sus pacientes y también ayudar a quienes se encuentran abocados a esta tarea.

  11. El láser CO2 y sus aplicaciones en oftalmología veterinaria

    OpenAIRE

    Torrubia, I.

    2012-01-01

    El LASER (Light Amplification by Stimulated Emision of Radiation) es una fuente de energía descubierta a finales de los años 50 que se emplea en multitud de campos y que ha evolucionado constantemente desde entonces, obteniéndose multitud de tipos de láser en función de la longitud de onda con la que se trabaje. Este gran avance no puede dejar de tener sus aplicaciones en la medicina. Este artículo hace una referencia básica sobre los diferentes tipos de láser y sus características, tratando ...

  12. El desarrollo psicomotor y sus alteraciones: entre lo normal y lo patológico

    OpenAIRE

    Agustina Vericat; Alicia Bibiana Orden

    2013-01-01

    El siguiente artículo discute aspectos propios del desarrollo psicomotor (DPM) y sus alteraciones, con especial énfasis en el retraso psicomotor. Se hace referencia a las clasificaciones diagnósticas para los problemas del desarrollo como el DSMIV y el CIE 10, y se analizan sus ventajas y desventajas. También se problematiza el concepto de normalidad en tanto sinónimo de promedio estadístico en el contexto de los problemas del DPM, para considerar su dinámica y variabilidad, evitando la oposi...

  13. Sus cuerpos, nuestras vidas: torso desnudo y mandil en la historia mixteca de la costa

    OpenAIRE

    Gómez-Montes, Liliana María

    2016-01-01

    En la región costera de Oaxaca, en México, hay diversos pueblos mixtecos que nos cuentan algo de su historia a través de sus formas de vestir. Hoy en día podemos encontrar en algunas de sus comunidades que las mujeres usan su pozahuanco (falda de algodón local, a rayas). Unas llevan el torso desnudo, otras lo han cubierto con un mandil de tela de algodón industrial. A través de entrevistas con las mujeres mayores del lugar he ido reconstruyendo su memoria colectiva acerca del proceso de tapar...

  14. Cirrosis hepática: medidas preventivas de algunas de sus complicaciones

    OpenAIRE

    A. Claudio L. Toledo, Dr.

    2010-01-01

    Cirrosis hepática es una enfermedad prevalente en el mundo. Su diagnóstico y tratamiento debe ser dominio de todo médico general e internista. En los últimos años han ocurrido notables avances en el diagnóstico, fisiopatología, tratamiento y en la identificación de factores pronósticos de cirrosis y de sus complicaciones mayores. Particular atención ha existido en desarrollar medidas preventivas de sus complicaciones como por ejemplo: hemorragia por várices esofágicas, peritonitis bacte...

  15. Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A.

    Science.gov (United States)

    Nguyen, G N; George, L A; Siner, J I; Davidson, R J; Zander, C B; Zheng, X L; Arruda, V R; Camire, R M; Sabatino, D E

    2017-01-01

    Essentials Factor (F) VIII is an inefficiently expressed protein. Furin deletion FVIII variants were purified and characterized using in vitro and in vivo assays. These minimally modified novel FVIII variants have enhanced function. These variants provide a strategy for increasing FVIII expression in hemophilia A gene therapy. Background The major challenge for developing gene-based therapies for hemophilia A is that human factor VIII (hFVIII) has intrinsic properties that result in inefficient biosynthesis. During intracellular processing, hFVIII is predominantly cleaved at a paired basic amino acid cleaving enzyme (PACE) or furin cleavage site to yield a heterodimer that is the major form of secreted protein. Previous studies with B-domain-deleted (BDD) canine FVIII and hFVIII-R1645H, both differing from hFVIII by a single amino acid at this site, suggested that these proteins are secreted mainly in a single polypeptide chain (SC) form and exhibit enhanced function. Objective We hypothesized that deletion(s) of the furin site modulates FVIII biology and may enhance its function. Methods A series of recombinant hFVIII-furin deletion variants were introduced into hFVIII-BDD [Δ1645, 1645-46(Δ2), 1645-47(Δ3), 1645-48(Δ4), or Δ1648] and characterized. Results In vitro, recombinant purified Δ3 and Δ4 were primarily SC and, interestingly, had 2-fold higher procoagulant activity compared with FVIII-BDD. In vivo, the variants also have improved hemostatic function. After adeno-associated viral (AAV) vector delivery, the expression of these variants is 2-4-fold higher than hFVIII-BDD. Protein challenges of each variant in mice tolerant to hFVIII-BDD showed no anti-FVIII immune response. Conclusions These data suggest that the furin deletion hFVIII variants are superior to hFVIII-BDD without increased immunogenicity. In the setting of gene-based therapeutics, these novel variants provide a unique strategy to increase FVIII expression, thus lowering the vector dose, a

  16. Limit of detection and threshold for positivity of the Centers for Disease Control and Prevention assay for factor VIII inhibitors.

    Science.gov (United States)

    Miller, C H; Boylan, B; Shapiro, A D; Lentz, S R; Wicklund, B M

    2017-10-01

    Essentials Immunologic methods detect factor VIII (FVIII) antibodies in some inhibitor-negative specimens. Specimens were tested by modified Nijmegen-Bethesda assay (NBA) and fluorescence immunoassay. The NBA with preanalytical heat inactivation detects FVIII inhibitors down to 0.2 NBU. IgG 4 frequency validates the established threshold for positivity of ≥ 0.5 NBU for this NBA. Background The Bethesda assay for measurement of factor VIII inhibitors called for quantification of positive inhibitors by using dilutions producing 25-75% residual activity (RA), corresponding to 0.4-2.0 Bethesda units, with the use of 'more sensitive methods' for samples with RA closer to 100% being recommended. The Nijmegen modification (Nijmegen-Bethesda assay [NBA]) changed the reagents used but not these calculations. Some specimens negative by the NBA have been shown to have FVIII antibodies detectable with sensitive immunologic methods. Objective To examine the performance at very low inhibitor titers of the Centers for Disease Control and Prevention (CDC)-modified NBA (CDC-NBA), which includes preanalytic heat inactivation to liberate bound anti-FVIII antibodies. Methods Specimens with known inhibitors were tested with the CDC-NBA. IgG 4 anti-FVIII antibodies were measured by fluorescence immunoassay (FLI). Results Diluted inhibitors showed linearity below 0.4 Nijmegen-Bethesda units (NBU). With four statistical methods, the limit of detection of the CDC-NBA was determined to be 0.2 NBU. IgG 4 anti-FVIII antibodies, which correlate most strongly with functional inhibitors, were present at rates above the background rate of healthy controls in specimens with titers ≥ 0.2 NBU and showed an increase in frequency from 14.3% at 0.4 NBU to 67% at the established threshold for positivity of 0.5 NBU. Conclusions The CDC-NBA can detect inhibitors down to 0.2 NBU. The FLI, which is more sensitive, demonstrates anti-FVIII IgG 4 in some patients with negative (NBA, supporting the need for

  17. Factors Associated with the Time of Admission among Notified Dengue Fever Cases in Region VIII Philippines from 2008 to 2014.

    Directory of Open Access Journals (Sweden)

    Jason Echavez Abello

    2016-10-01

    Full Text Available In cases of Dengue fever, late hospital admission can lead to treatment delay and even death. In order to improve early disease notification and management, it is essential to investigate the factors affecting the time of admission of Dengue cases. This study determined the factors associated with the time of admission among notified Dengue cases. The study covered the period between 2008 and 2014 in Region VIII, Philippines. The factors assessed were age, sex, hospital sector, hospital level, disease severity based on the 1997 WHO Dengue classification, and period of admission (distinguishing between the 2010 Dengue epidemic and non-epidemic time. We analysed secondary data from the surveillance of notified Dengue cases. We calculated the association through chi-square test, ordinal logistic regression and linear regression at p value < 0.05. The study included 16,357 admitted Dengue cases. The reported cases included a majority of children (70.09%, mild cases of the disease (64.00%, patients from the public sector (69.82%, and non-tertiary hospitals (62.76%. Only 1.40% of cases had a laboratory confirmation. The epidemic period in 2010 comprised 48.68% of all the admitted cases during this period. Late admission was more likely among adults than children (p<0.05. The severe type of the disease was more likely to be admitted late than the mild type (p<0.05. Late admission was also more likely in public hospitals than in private hospitals (p<0.05; and within tertiary level hospitals than non-tertiary hospitals (p<0.05. Late admission was more likely during the non-epidemic period than the 2010 epidemic period (p<0.05. A case fatality rate of 1 or greater was significantly associated with children, severe diseases, tertiary hospitals and public hospitals when admitted late (p<0.05. Data suggests that early admission among child cases was common in Region VIII. This behavior is encouraging, and should be continued. However, further study is needed

  18. ENDF/B-VIII.0: The 8th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data

    Science.gov (United States)

    Brown, D. A.; Chadwick, M. B.; Capote, R.; Kahler, A. C.; Trkov, A.; Herman, M. W.; Sonzogni, A. A.; Danon, Y.; Carlson, A. D.; Dunn, M.; Smith, D. L.; Hale, G. M.; Arbanas, G.; Arcilla, R.; Bates, C. R.; Beck, B.; Becker, B.; Brown, F.; Casperson, R. J.; Conlin, J.; Cullen, D. E.; Descalle, M.-A.; Firestone, R.; Gaines, T.; Guber, K. H.; Hawari, A. I.; Holmes, J.; Johnson, T. D.; Kawano, T.; Kiedrowski, B. C.; Koning, A. J.; Kopecky, S.; Leal, L.; Lestone, J. P.; Lubitz, C.; Márquez Damián, J. I.; Mattoon, C. M.; McCutchan, E. A.; Mughabghab, S.; Navratil, P.; Neudecker, D.; Nobre, G. P. A.; Noguere, G.; Paris, M.; Pigni, M. T.; Plompen, A. J.; Pritychenko, B.; Pronyaev, V. G.; Roubtsov, D.; Rochman, D.; Romano, P.; Schillebeeckx, P.; Simakov, S.; Sin, M.; Sirakov, I.; Sleaford, B.; Sobes, V.; Soukhovitskii, E. S.; Stetcu, I.; Talou, P.; Thompson, I.; van der Marck, S.; Welser-Sherrill, L.; Wiarda, D.; White, M.; Wormald, J. L.; Wright, R. Q.; Zerkle, M.; Žerovnik, G.; Zhu, Y.

    2018-02-01

    We describe the new ENDF/B-VIII.0 evaluated nuclear reaction data library. ENDF/B-VIII.0 fully incorporates the new IAEA standards, includes improved thermal neutron scattering data and uses new evaluated data from the CIELO project for neutron reactions on 1H, 16O, 56Fe, 235U, 238U and 239Pu described in companion papers in the present issue of Nuclear Data Sheets. The evaluations benefit from recent experimental data obtained in the U.S. and Europe, and improvements in theory and simulation. Notable advances include updated evaluated data for light nuclei, structural materials, actinides, fission energy release, prompt fission neutron and γ-ray spectra, thermal neutron scattering data, and charged-particle reactions. Integral validation testing is shown for a wide range of criticality, reaction rate, and neutron transmission benchmarks. In general, integral validation performance of the library is improved relative to the previous ENDF/B-VII.1 library.

  19. Alterations in hemostatic parameters during hemodialysis with dialyzers of different membrane composition and flow design. Platelet activation and factor VIII-related von Willebrand factor during hemodialysis.

    Science.gov (United States)

    Schmitt, G W; Moake, J L; Rudy, C K; Vicks, S L; Hamburger, R J

    1987-09-01

    The effect of dialyzer membrane and design on hemostatic parameters during hemodialysis were evaluated in a prospective controlled study. This study demonstrated that hemodialysis is associated with significant platelet activation and loss, which are influenced by both dialyzer configuration and membrane composition. In addition, use of the cuprophan membrane is associated with greater perturbations of the vascular endothelium, as reflected in changes in factor VIII-related von Willebrand factor and 6-keto-prostaglandin F1 alpha concentrations not seen with the polyacrylonitrile membrane. Of the dialyzers studied, the polyacrylonitrile membrane in a hollow-fiber configuration appears to minimize platelet loss and activation, and to minimize increases in factor VIII-related von Willebrand factor and 6-keto-prostaglandin F1 alpha.

  20. Evaluation of the expression of VIII factor and VEGF in the regeneration of non-vital teeth in dogs using propolis

    Directory of Open Access Journals (Sweden)

    Mina Zarei

    2017-02-01

    Full Text Available Objective(s: The purpose of the present study was the immunohistochemical evaluation of VEGF and VII factors in dog’s teeth pulp revascularized with MTA and propolis. Materials and Methods: 144 mature and immature two rooted dog’s premolar canals were selected.  Pulp necrosis and infection were established after 2 weeks and the disinfection of the canals was done with copious NaOCl irrigation and triantibiotic mixture (ciprofloxacin, metronidazole, and minocycline for 3 weeks. Subsequently, the blood clot was evoked in the canal by periapical tissue irritation with a k-file. The samples were randomly divided into 6 experimental groups: propolis (groups 1, 2, MTA (groups 3, 4, and parafilm (groups 5, 6 in immature and mature teeth. The animals were sacrificed and samples were prepared for immunohistochemical evaluation of VEGF and the VIII factor. Results: Tissue regeneration was seen in 64.5% of MTA, 38% of propolis, and 0% of parafilm group samples. Expression of VEGF and VIII factor in the propolis group was more than the MTA group and it showed a reduction after 3 months in comparison to 1 month. VEGF and VIII factor were seen in stromal cells in addition to endothelial vessel cells. Overall, expression of angiogenic factors was more in the open apex teeth compared to close apex ones. Conclusion: According to the results of this study, propolis can induce the expression of VEGF and VIII factor in infected mature and immature dog’s teeth and is a suitable biomaterial for the revascularization technique.

  1. PENINGKATAN AKTIVITAS DAN HASIL BELAJAR POKOK BAHASAN PASAR DENGAN METODE RESITASI PADA SISWA KELAS VIII SMP NEGERI 24 SEMARANG TAHUN AJARAN 2013/2014

    Directory of Open Access Journals (Sweden)

    Diinul Qoyyimah

    2013-11-01

    Full Text Available Aktivitas siswa kelas VIII pada mata pelajaran ekonomi SMP Negeri 24 Semarang pada pokok bahasan pasar masih rendah sehingga berdampak pada hasil belajar siswa yang masih dibawah KKM. Salah satu penyebabnya karena guru masih menerapkan metode belajar yang sama dalam waktu yang lama sehingga mengakibatkan rendahnya perolehan hasil belajar. Melalui penerapan metode ceramah bervariasi dan resitasi diharapkan siswa dapat belajar dengan santai dan senang dalam mengikuti proses pembelajaran. Penelitian ini bertujuan untuk mengetahui penerapan metode resitasi, dapat meningkatkan aktivitas dan hasil belajar siswa. Metode penelitian menggunakan penelitian tindakan kelas. Prosedur penelitian dilakukan dimulai dengan perencanaan, pelaksanaan, observasi dan refleksi. Metode pengumpulan data dengan dokumentasi dan tes. Hasil penelitian menyatakan bahwa ada peningkatan aktivitas siswa dan hasil belajar siswa materi pasar pada kelas VIII SMP Negeri 24 Semarang tahun 2013/2014. The students’ activity in VIII class of economic subject in SMP Negeri 24 Semarang in the subject matter of market topic is still low so it has the impact on the students’ learning outcome which is still under KKM requirements. One of the causes is because the teachers are still apply the same learning method in a long time so it resulted in low learning outcomes acquisition.through the application of various conventional methods and recitation are expected that students can learn easily and pleasure in participating of learning process. This study aims to determine the application of recitation method which can improve the activity and students’ learning outcomes. The research method using classroom action research. The research procedure begins with planning, implementation, observation and reflection. Methods of data collection carried out by documentation and test. The result of research states that there is an increasing activity and students’ learning outcomes in the

  2. Hubungan Self-esteem dan Penggunaan Media Sosial Instagram dengan Perilaku Narsisme di Kalangan Siswa Kelas VIII Smpk Penabur Bintaro Jaya

    OpenAIRE

    Wibowo, Yonatan; Silaen, Sondang Maria J

    2018-01-01

    Tujuan dari penelitian ini adalah untuk mengetahui ada tidaknya hubungan self-esteem dan penggunaanmedia sosial Instagram dengan perilaku narsisme di kalangan siswa kelas VIII SMPK Penabur Bintaro Jaya.Dalam penelitian ini terdapat tiga variabel, yaitu perilaku narsisme sebagai variabel terikat serta self-esteem danpenggunaan media sosial Instagram sebagai variabel bebas. Sampel dalam penelitian ini adalah siswa kelasdelapan tahun pelajaran 2016/2017. Teknik pengambilan sampel dalam penelitia...

  3. Enologia avui, 2009: Resums de les ponències presentades a les VIII Jornades d'Actualització en Viticultura i Enologia

    OpenAIRE

    Diversos Autors; Albert Bordons de Porrata-Doria

    2010-01-01

    Aquest llibre recull els resums de les ponències de les VIII Jornades d’Actualització en Viticultura i Enologia (Vilafranca del Penedès, maig de 2009), organitzades per la Facultat d’Enologia de Tarragona, on es van tractar aspectes novedosos de recerca i innovació, amb un aprofundiment en les repercusions del canvi climàtic sobre la vitivinicultura.

  4. Anterior Inferior Cerebellar Arteries Juxtaposed with the Internal Acoustic Meatus and Their Relationship to the Cranial Nerve VII/VIII Complex.

    Science.gov (United States)

    Alonso, Fernando; Kassem, Mohammad W; Iwanaga, Joe; Oskouian, Rod J; Loukas, Marios; Demerdash, Amin; Tubbs, R Shane

    2017-08-16

    Vascular loops in the cerebellopontine angle (CPA) and their relationship to cranial nerves have been used to explain neurological symptoms. The anterior inferior cerebellar artery (AICA) has variable branches producing vascular loops that can compress the facial cranial nerve (CN) VII and vestibulocochlear (CN VIII) nerves. AICA compression of the facial-vestibulocochlear nerve complex can lead to various clinical presentations, including hemifacial spasm (HFS), tinnitus, and hemiataxia. The formation of arterial loops inside or outside of the internal auditory meatus (IAM) can cause abutment or compression of CN VII and CN VIII. Twenty-five (50 sides) fresh adult cadavers underwent dissection of the cerebellopontine angle in the supine position. In regard to relationships between the AICA and the nerves of the facial/vestibulocochlear complex, 33 arteries (66%) traveled in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Five arteries (10%) traveled below the CN VII/VIII complex, six (12%) traveled posterior to the nerve complex, four (8%) formed a semi-circle around the upper half of the nerve complex, and two (4%) traveled between and partially separated the nervus intermedius and facial nerve proper. Our study found that the majority of AICA will travel in a plane between the facial/nervus intermedius nerves and the cochlear and vestibular nerves. Although the relationship between the AICA and porus acusticus and AICA and the nerves of the CN VII/VIII complex are variable, based on our findings, some themes exist. Surgeons should consider these with approaches to the cerebellopontine angle.

  5. Perancangan Material Handling Equipment Pada Proses Penggilingan Ke Oksidasi Enzimatis Bubuk Teh Menggunakan Metode Perancangan Produk Rasional Pada PT Perkebunan Nusantara VIII Rancabali

    OpenAIRE

    Lestari, Imelia Rizki; Anugraha, Rino Andias; Iqbal, Muhammad

    2016-01-01

    PT Perkebunan Nusantara VIII Rancabali merupakan salah satu Perusahaan pengolahan teh hitam ortodoks di Indonesia yang menghasilkan dua belas jenis teh hitam untuk dijual di dalam negeri maupun diekspor ke beberapa negara. Kualitas teh yang dihasilkan oleh Perusahaan ini tentunya akan mempengaruhi harga teh yang akan dijual. Dalam proses pengolahan teh hitam ortodoks, proses oksidasi enzimatis merupakan proses yang paling menentukan kualitas bubuk teh yang akan dihasilkan nantinya, sehingga d...

  6. Design local exhaust ventilation on sieve machine at PT.Perkebunan Nusantara VIII Ciater using design for assembly (DFA) approach with Boothroyd and Dewhurst method

    Science.gov (United States)

    Khalqihi, K. I.; Rahayu, M.; Rendra, M.

    2017-12-01

    PT Perkebunan Nusantara VIII Ciater is a company produced black tea orthodox more or less 4 tons every day. At the production section, PT Perkebunan Nusantara VIII will use local exhaust ventilation specially at sortation area on sieve machine. To maintain the quality of the black tea orthodox, all machine must be scheduled for maintenance every once a month and takes time 2 hours in workhours, with additional local exhaust ventilation, it will increase time for maintenance process, if maintenance takes time more than 2 hours it will caused production process delayed. To support maintenance process in PT Perkebunan Nusantara VIII Ciater, designing local exhaust ventilation using design for assembly approach with Boothroyd and Dewhurst method, design for assembly approach is choosen to simplify maintenance process which required assembly process. There are 2 LEV designs for this research. Design 1 with 94 components, assembly time 647.88 seconds and assembly efficiency level 23.62%. Design 2 with 82 components, assembly time 567.84 seconds and assembly efficiency level 24.83%. Design 2 is choosen for this research based on DFA goals, minimum total part that use, optimization assembly time, and assembly efficiency level.

  7. The Safety and Feasibility of Three-Dimensional Visualization Technology Assisted Right Posterior Lobe Allied with Part of V and VIII Sectionectomy for Right Hepatic Malignancy Therapy.

    Science.gov (United States)

    Hu, Min; Hu, Haoyu; Cai, Wei; Mo, Zhikang; Xiang, Nan; Yang, Jian; Fang, Chihua

    2017-11-27

    Hepatectomy is the optimal method for liver cancer; the virtual liver resection based on three-dimensional visualization technology (3-DVT) could provide better preoperative strategy for surgeon. We aim to introduce right posterior lobe allied with part of V and VIII sectionectomy assisted by 3-DVT as a promising treatment for massive or multiple right hepatic malignancies to retain maximum residual liver volume on the basis of R0 resection. Among 126 consecutive patients who underwent hepatectomy, 9 (7%) underwent right posterior lobe allied with part of V and VIII sectionectomy. 21 (17%) underwent right hemihepatectomy (RH). The virtual RH was performed with 3-DVT, which provided better observation of spatial position relationship between tumor and vessels, and the more accurate estimation of the remnant liver volume. If remnant liver volume was transfusion, operation length, liver function, and postoperative complications, were similar between two groups before and after propensity matching. The postoperative first, third, fifth, and seventh days mean value of aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), and total bilirubin had no significant difference compared with preoperative value. One patient in each group had recurrence six months after surgery. Right posterior lobe allied with part of V and VIII sectionectomy based on 3-DVT is safe and feasible surgery way, and can be a very promising method in massive or multiple right hepatic malignancy therapy.

  8. Enhancement of pig embryonic implants in factor VIII KO mice: a novel role for the coagulation cascade in organ size control.

    Science.gov (United States)

    Aronovich, Anna; Tchorsh, Dalit; Shezen, Elias; Rosen, Chava; Klionsky, Yael; Cohen, Sivan; Tal, Orna; Martinowitz, Uri; Katchman, Helena; Eventov-Friedman, Smadar; Amariglio, Ninette; Jacob-Hirsch, Jasmine; Rechavi, Gideon; Reisner, Yair

    2009-12-21

    Very little is known about the mechanisms that contribute to organ size differences between species. In the present study, we used a mouse model of embryonic pig tissue implantation to define the role of host Factor VIII in controlling the final size attained by the implant. We show here that pig embryonic spleen, pancreas, and liver all grow to an increased size in mice that are deficient in the Factor VIII clotting cascade. Similar results were obtained using the transplantation model after treatment with the low molecular weight heparin derivative Clexane which markedly enhanced transplant size. Likewise, enhanced size was found upon treatment with the direct thrombin inhibitor Dabigatran, suggesting that organ size regulation might be mediated by thrombin, downstream of Factor VIII. Considering that thrombin was shown to mediate various functions unrelated to blood clotting, either directly by cleavage of protease-activated receptors (PARs) or indirectly by cleaving osteopontin (OPN) on stroma cells, the role of PAR1 and PAR4 antagonists as well as treatment with cleaved form of OPN (tcOPN) were tested. While the former was not found to have an impact on overgrowth of embryonic pig spleen implants, marked reduction of size was noted upon treatment with the (tcOPN). Collectively, our surprising set of observations suggests that factors of the coagulation cascade have a novel role in organ size control.

  9. PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBANTUAN PEMETAAN PIKIRAN (MIND MAPPING TERHADAP KEMAMPUAN MENULIS TEKS BERITA SISWA KELAS VIII SMP NEGERI 1 PANTI

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    Ricci Gemarni Tatalia, M.Pd

    2017-05-01

    Full Text Available This study was generated from the problem of students’ ability in writing news texts ini class VIII, SMPN 1 Panti. Some of the problem were (1 lack of the students’ response towards news writing teaching and learning process, (2 lack of teacher’s creativity in designing interesting news sriting learning model, (3 no appropriate creative techniques applied by the teacher which could train the students to develop their skill in writing news texts and (4 lack of the students’ motivation in participating in teaching and learning process because of their lack of understanding in the elements of news. Thus, this study was aimed at escribing the effect of the students’ ability ini writing news texts in class VIII SMP N 1 Panti. This was a quantitative research with factorial 2x2 experimental design. The population was the students in class VIII SMPN 1 Panti. Sampling technique was done by using random sampling and the data was collected through test. The result of the study revealed that cooperative learning model with STAD mind mapping type affected the students’ ability in writing news texts

  10. Integralidade, uma diretriz do SUS para a vigilância sanitária Integral care, a SUS (Brazilian Unified Health System guideline for the sanitary surveillance

    Directory of Open Access Journals (Sweden)

    Gisele O'Dwyer

    2010-11-01

    Full Text Available A vigilância sanitária atua através de práticas e objetos diversos e suas ações são orientadas pelos mesmos princípios e diretrizes do Sistema Único de Saúde (SUS. Propusemos uma reflexão crítica sobre as condições de interação da prática de vigilância sanitária com uma proposição constitucional do SUS, a integralidade. Realizou-se uma análise baseada na Teoria da Estruturação, de Giddens, que considera a mobilização de recursos estruturais como uma dimensão de interação social que justifica a legitimação exercida pela sanção de normas. Foram ordenadas como categorias de análise: Visa e sua inserção no SUS; o princípio da integralidade e a Visa; e entraves políticos. A vigilância sanitária vem-se organizando a partir da Anvisa e atualmente assume novas responsabilidades sanitárias, entre elas a comunicação com a sociedade e ações de promoção da saúde. A discussão na literatura para a integralidade baseia-se no aspecto assistencial. A organização dos serviços nos diferentes entes federativos é o sentido de integralidade mais incorporado pela Visa. Os entraves políticos estão na renovação institucional, na arena de conflitos de interesses, na distância entre políticas formuladas e instituídas, e nas lacunas referentes à gestão do trabalho e à insuficiência do financiamento.The sanitary surveillance (Visa performs several practices, on different objects and its actions are guided by principles and guidelines of the SUS. It was done a critical reflection on the interaction conditions of practice in Visa, with a constitutional proposition of the SUS: integral care. The analysis was based on the theory of structuration (Giddens that considers mobilization of structural resources as dimensions of social interaction, which would justify the legitimacy exercised since the standards. Have been analyzed the following categories: Visa and its insertion within the SUS; the integral care and the

  11. Comparison of methods of extracting messenger Ribonucleic Acid from ejaculated Porcine (Sus Scrofa) Spermatozoa

    Science.gov (United States)

    H. D. Guthrie, G.R. Welch, and L. A. Blomberg. Comparison of Methods of Extracting Messenger Ribonucleic Acid from Ejaculated Porcine (Sus Scrofa) Spermatozoa. Biotechnology and Germplasm Laboratory, Agricultural Research Service U. S. Department of Agriculture, Beltsville, MD 20705 The purpos...

  12. L'echographie sus-pubienne dans les anomalies du premier ...

    African Journals Online (AJOL)

    L'echographie sus-pubienne dans les anomalies du premier trimestre de la grossesse chez la femme a Lome a propos de 304 cas colliges au service de radiologie du chu-tokoin de Lome de Janvier 2005 a Decembre 2007.

  13. El docente investigador: su génesis teórica y sus rasgos

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    Natalia Campos Saborío

    2003-01-01

    Full Text Available El propósito de este artículo es enunciar los rasgos que caracterizan al docente investigador. Para ello, me ubico en el contexto teórico, desde dónde conceptualizo sus calidades, a saber: visión de mundo, de paradigma curricular, y de investigación educativa

  14. Regional sustainability contrasts in Brazil as indicated by the Compass of Sustainability – CompasSus

    NARCIS (Netherlands)

    Rodrigues-Filho, S.; Lindoso, D.P.; Bursztyn, M.; Brouwer, F.M.; Debortoli, N.; Castro, de V.M.

    2013-01-01

    The current need for assessing sustainable processes and states is a driving assumption for this article, having as objective to present preliminary results of a new assessment approach, the Compass of Sustainability (CompasSus), applied to administrative regions of Brazil. Its methodological

  15. La educación secundaria en Perú y sus profesores: cambios y continuidades

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    Jerson Chuquilin Cubas

    2011-01-01

    Full Text Available Desde el momento en el que se constituyó el nuevo Estado peruano independiente del poder político español, el poder estatal se encargó de fundar y normar la organización y funcionamiento de las instituciones que conforman lo que hoy se conoce como sistema educativo. Dentro de este proceso, la educación secundaria ha experimentado desarrollos peculiares que la diferencian de los otros niveles educativos en lo que se refiere a las instituciones en las que se imparte, sus propósitos, la formación de sus profesores, las posiciones instituidas y el sentido asignado al quehacer docente y directivo. Así, la educación secundaria nació ligada a la educación superior universitaria y al servicio de una minoría privilegiada. Sus profesores, de una élite privilegiada al servicio del proyecto homogeneizador del Estado, han transitado hacia una situación de deterioro de sus condiciones de vida y desvalorización de su trabajo.

  16. El migrante en Argentina y el acceso a sus derechos. Un breve recorrido por las normas, las políticas y sus historias

    Directory of Open Access Journals (Sweden)

    Abigail Gómez

    2014-06-01

    Full Text Available Diariamente llegan a Argentina inmigrantes provenientes de países vecinos, con deficiencias para acceder a sus derechos en su país de origen. El Estado argentino debió realizar diversas me- didas para protegerlos, sancionando normativa acorde a la incorporación de los Tratados y Pac- tos internacionales y realizando políticas y acciones públicas en clave de derechos humanos.Simultáneamente se pueden observar obstáculos a la hora de acceder efectivamente a esos derechos en pie de igualdad con los ciudadanos.Resulta pertinente analizar cómo estas personas ven satisfechos sus derechos al llegar al país utilizando, como estrategia metodológica, un estudio etnográfico.El análisis se dividirá en dos partes; se describirá cuáles son las herramientas con las que cuentan los migrantes a la hora de intentar acceder a esos derechos humanos básicos y se conocerá, mediante el análisis de fallos judiciales, entrevistas y documentos de ONGs abocadas a la temática, si efectivamente se cumple con la satisfacción de esos derechos.Como resultado se evidencia que si bien los inmigrantes encuentran en Argentina el acceso gratuito a las prestaciones que en sus países les es difícil alcanzar, existen insuficiencias cuanti- tativas y cualitativas de los servicios del Estado argentino, especialmente en el sistema sanitario y educativo.

  17. Body weight and fat mass index as strong predictors of factor VIII in vivo recovery in adults with hemophilia A.

    Science.gov (United States)

    Henrard, S; Speybroeck, N; Hermans, C

    2011-09-01

    The treatment of hemophilia A requires infusions of factor VIII (FVIII) concentrates. The number of units to be given in order to obtain the target level is calculated using the formula: [body weight (BW) × desired FVIII increase]/2, which assumes that each unit infused per kg of BW increases the FVIII level by 2%. The present observational study evaluated the dependence of FVIII recovery on different morphometrical variables: BW, fat mass index (FMI), body mass index, and the difference between actual and ideal BW. FVIII recovery was measured in 46 non-actively bleeding hemophilia A patients, being treated with a recombinant FVIII concentrate. Regression trees were used to identify morphometrical predictors of recovery. The median recovery was 2.08 for all patients, 2.63 for those with a BW ≥ 81.0 kg and 1.87 for others (P recovery was significantly higher when FMI was ≥ 20% compared with FMI recovery: 2.35 vs. 1.74; P = 0.007). Using regression trees, three groups were created: BW recovery in these groups was 1.80, 2.16 and 2.63, respectively (P recovery after different FVIII concentrates should keep in mind morphometrical patient characteristics. © 2011 International Society on Thrombosis and Haemostasis.

  18. Direct Observation of the M1 Transition between the Ground Term Fine Structure Levels of W VIII

    Directory of Open Access Journals (Sweden)

    Momoe Mita

    2017-03-01

    Full Text Available We present a direct observation of the M1 transition between the fine structure splitting in the 4 f 13 5 s 2 5 p 6 2 F ground term of W VIII. The spectroscopic data of few-times ionized tungsten ions are important for the future ITER diagnostics, but there is a serious lack of data. The present study is part of an ongoing effort to solve this problem. Emission from the tungsten ions produced and trapped in a compact electron beam ion trap is observed with a Czerny–Turner visible spectrometer. Spectra in the EUV range are also observed at the same time to help identify the previously-unreported visible lines. The observed wavelength 574.47 ± 0.03 nm (air, which corresponds to the fine structure splitting of 17,402.5 ± 0.9 cm − 1 , shows reasonable agreement with the previously reported value 17,410 ± 5 cm − 1 obtained indirectly through the analysis of EUV spectra [Ryabtsev et al., Atoms 3 (2015 273].

  19. The Abdication of King Edward VIII: a study of estrangement between an adult son and elderly mother.

    Science.gov (United States)

    Abrams, Robert C

    2018-03-01

    In this article the Abdication of King Edward VIII of Great Britain and his estrangement from the dowager Queen Mary are reconsidered as prototypes of intergenerational conflict arising from a collision of values between an adult child and an elderly mother. Historical materials on the Abdication and other respected secondary sources, including biographies of key individuals, were consulted, and the limited sociological and clinical literature on estrangement between elderly parents and adult children was referenced. Although estrangement was perpetuated by the rigid and incompatible positions taken up by both the former king and his widowed mother, the elderly Queen Mary, it was the latter who suffered the greater emotional consequences of the permanent separation that followed the Abdication. Most accounts of the Abdication have put forward views of the conflict of values at its centre that emphasise the vulnerability of the elderly mother. The clinical narrative supports a characterisation of estrangement as a subtype of bereavement with particular relevance to the geriatric population. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  20. Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs.

    Science.gov (United States)

    Jiang, Haiyan; Lillicrap, David; Patarroyo-White, Susannah; Liu, Tongyao; Qian, Xiaobing; Scallan, Ciaran D; Powell, Sandra; Keller, Tracey; McMurray, Morag; Labelle, Andrea; Nagy, Dea; Vargas, Joseph A; Zhou, Shangzhen; Couto, Linda B; Pierce, Glenn F

    2006-07-01

    Hemophilia A, a deficiency of functional coagulation factor VIII (FVIII), is treated via protein replacement therapy. Restoring 1% to 5% of normal blood FVIII activity prevents spontaneous bleeding, making the disease an attractive gene therapy target. Previously, we have demonstrated short-term activity of a liver-specific AAV2 vector expressing canine B-domain-deleted FVIII (cFVIII) in a hemophilia canine model. Here, we report the long-term efficacy and safety of AAV-cFVIII vectors of serotypes 2, 5, 6, and 8 in both hemophilia A mice and dogs. AAV6-cFVIII and AAV8-cFVIII restored physiologic levels of plasma FVIII activity in hemophilia A mice. The improved efficacy is attributed to more efficient gene transfer in liver compared with AAV2 and AAV5. However, supraphysiologic cFVIII levels correlated with the formation of cFVIII-neutralizing antibodies in these mice. Of importance, hemophilia A dogs that received AAV2-cFVIII, AAV6-cFVIII, and AAV8-cFVIII have persistently expressed therapeutic levels of FVIII, without antibody formation or other toxicities, for more than 3 years. However, liver transduction efficiencies are similar between AAV2, AAV6, and AAV8 serotypes in hemophilia A dogs, in contrast to mice. In summary, this is the first report demonstrating multiyear therapeutic efficacy and safety of multiple AAV-cFVIII vectors in hemophilia A dogs and provides the basis for human clinical studies.

  1. Genotype and phenotype report on patients with combined deficiency of factor V and factor VIII in Iran.

    Science.gov (United States)

    Karimi, Mehran; Cairo, Andrea; Safarpour, Mohammad M; Haghpanah, Sezaneh; Ekramzadeh, Maryam; Afrasiabi, Abdolreza; Shahriari, Mahdi; Menegatti, Marzia

    2014-06-01

    Combined factor V (FV) and factor VIII (FVIII) deficiency is a rare autosomal recessive bleeding disorder characterized by mild-to-moderate bleeding. Epistaxis, postsurgical bleeding and menorrhagia are the most common symptoms. The aim of this study is to report the phenotype-genotype characterization carried out in patients affected with combined FV and FVIII deficiency from Iran. A cross-sectional study was conducted in Shiraz Hemophilia Center, southern Iran. Twelve cases, seven men and five women coming from eight families were included in our study after taking consent form. Coagulation activity for all patients was measured. All exons and intron-exon junctions of lectin mannose binding protein 1 (LMAN1) gene and multiple coagulation factor deficiency 2 genes were amplified by PCR, and subsequently sequenced by the Sanger method. Patients[Combining Acute Accent] age ranged from 6 to 59 years mean ± SD: 23.8 ± 15.4 years and median: 22 years. No patient presented with severe bleeding symptom. Only one patient had severe FV and FVIII deficiency (both factor levels stop codon. Larger studies are needed to calculate the correlation between factor levels, genetic and bleeding symptoms.

  2. Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2

    Science.gov (United States)

    Zhang, Bin; McGee, Beth; Yamaoka, Jennifer S.; Guglielmone, Hugo; Downes, Katharine A.; Minoldo, Salvador; Jarchum, Gustavo; Peyvandi, Flora; de Bosch, Norma B.; Ruiz-Saez, Arlette; Chatelain, Bernard; Olpinski, Marian; Bockenstedt, Paula; Sperl, Wolfgang; Kaufman, Randal J.; Nichols, William C.; Tuddenham, Edward G. D.; Ginsburg, David

    2006-01-01

    Mutations in LMAN1 (ERGIC-53) or MCFD2 cause combined deficiency of factor V and factor VIII (F5F8D). LMAN1 and MCFD2 form a protein complex that functions as a cargo receptor ferrying FV and FVIII from the endoplasmic reticulum to the Golgi. In this study, we analyzed 10 previously reported and 10 new F5F8D families. Mutations in the LMAN1 or MCFD2 genes accounted for 15 of these families, including 3 alleles resulting in no LMAN1 mRNA accumulation. Combined with our previous reports, we have identified LMAN1 or MCFD2 mutations as the causes of F5F8D in 71 of 76 families. Among the 5 families in which no mutations were identified, 3 were due to misdiagnosis, with the remaining 2 likely carrying LMAN1 or MCFD2 mutations that were missed by direct sequencing. Our results suggest that mutations in LMAN1 and MCFD2 may account for all cases of F5F8D. Immunoprecipitation and Western blot analysis detected a low level of LMAN1-MCFD2 complex in lymphoblasts derived from patients with missense mutations in LMAN1 (C475R) or MCFD2 (I136T), suggesting that complete loss of the complex may not be required for clinically significant reduction in FV and FVIII. PMID:16304051

  3. Application of near infrared spectroscopy in monitoring the moisture content in freeze-drying process of human coagulation factor VIII

    Directory of Open Access Journals (Sweden)

    Fei Wang

    2015-11-01

    Full Text Available As an important process analysis tool, near infrared spectroscopy (NIRS has been widely used in process monitoring. In the present work, the feasibility of NIRS for monitoring the moisture content of human coagulation factor VIII (FVIII in freeze-drying process was investigated. A partial least squares regression (PLS-R model for moisture content determination was built with 88 samples. Different pre-processing methods were explored, and the best method found was standard normal variate (SNV transformation combined with 1st derivation with Savitzky–Golay (SG 15 point smoothing. Then, four different variable selection methods, including uninformative variable elimination (UVE, interval partial least squares regression (iPLS, competitive adaptive reweighted sampling (CARS and manual method, were compared for eliminating irrelevant variables, and iPLS was chosen as the best variable selection method. The correlation coefficient (R, correlation coefficient of calibration set (Rcal, correlation coefficient of validation set (Rval, root mean square errors of cross-validation (RMSECV and root mean square errors of prediction (RMSEP of PLS model were 0.9284, 0.9463, 0.8890, 0.4986% and 0.4514%, respectively. The results showed that the model for moisture content determination has a wide range, good linearity, accuracy and precision. The developed approach was demonstrated to be a potential for monitoring the moisture content of FVIII in freeze-drying process.

  4. Potency determination of factor VIII and factor IX for new product labelling and postinfusion testing: challenges for caregivers and regulators.

    Science.gov (United States)

    Dodt, J; Hubbard, A R; Wicks, S J; Gray, E; Neugebauer, B; Charton, E; Silvester, G

    2015-07-01

    A workshop organized by the European Medicines Agency and the European Directorate for the Quality of Medicines and HealthCare was held in London, UK on November 28-29, 2013, to provide an overview of the current knowledge of the characterization of new factor VIII (FVIII) and factor IX (FIX) concentrates with respect to potency assays and testing of postinfusion material. The objective was to set the basis for regulatory authorities' discussion on the most appropriate potency assay for the individual products, and European Pharmacopoeia (Ph. Eur.) discussion on whether to propose revision of the Ph. Eur. monographs with respect to potency assays in the light of information on new FVIII and FIX concentrates. The workshop showed that for all products valid assays vs. the international concentrate standards were obtained and potency could be expressed in International Units. The Ph. Eur. chromogenic potency assay gave valid assay results which correlate with in vivo functionality of rFVIII products. For some modified rFVIII products and all modified rFIX products, one-stage clotting assay methods result in different potencies depending on the activated partial thromboplastin time reagent. As a consequence, monitoring of patients' postinfusion levels is challenging but it was pointed out that manufacturers are responsible for providing the users with appropriate information for use and laboratory testing of their product. Strategies to avoid misleading determination of patents' plasma levels, e.g. information on suitable assays, laboratory standards or correction factors were discussed. © 2015 John Wiley & Sons Ltd.

  5. Effect of manufacturing process parameters on virus inactivation by dry heat treatment at 80 degrees C in factor VIII.

    Science.gov (United States)

    Roberts, P L; Dunkerley, C; McAuley, A; Winkelman, L

    2007-01-01

    Dry heat treatment at 80 degrees C for 72 h is used as a virus inactivation step for some coagulation factor concentrates such as Bio Products Laboratory's (BPL) factor VIII 8Y. In the current study, the effect of this process has been tested on a range of viruses. In addition the effect of various manufacturing process parameters on virus inactivation has been investigated. Samples of product intermediate were obtained from manufacturing, spiked with virus and subjected to freeze drying and dry heat treatment. Virus inactivation was determined by infectivity assay. Freeze drying followed by dry heat treatment was effective for inactivating a wide range of enveloped and nonenveloped viruses. Sucrose or protein concentration had no effect on virus inactivation. Product presentation or the interruption of heat treatment also had no effect. The inactivation of some of the viruses was greater at higher residual water content but under such conditions the stability of the product was reduced. This virus inactivation step was effective for a wide range of viruses and over the range of process conditions encountered in manufacturing. This demonstrates the robustness of this process step.

  6. Factors Associated with the Time of Admission among Notified Dengue Fever Cases in Region VIII Philippines from 2008 to 2014.

    Science.gov (United States)

    Abello, Jason Echavez; Gil Cuesta, Julita; Cerro, Boyd Roderick; Guha-Sapir, Debarati

    2016-10-01

    In cases of Dengue fever, late hospital admission can lead to treatment delay and even death. In order to improve early disease notification and management, it is essential to investigate the factors affecting the time of admission of Dengue cases. This study determined the factors associated with the time of admission among notified Dengue cases. The study covered the period between 2008 and 2014 in Region VIII, Philippines. The factors assessed were age, sex, hospital sector, hospital level, disease severity based on the 1997 WHO Dengue classification, and period of admission (distinguishing between the 2010 Dengue epidemic and non-epidemic time). We analysed secondary data from the surveillance of notified Dengue cases. We calculated the association through chi-square test, ordinal logistic regression and linear regression at p value Dengue cases. The reported cases included a majority of children (70.09%), mild cases of the disease (64.00%), patients from the public sector (69.82%), and non-tertiary hospitals (62.76%). Only 1.40% of cases had a laboratory confirmation. The epidemic period in 2010 comprised 48.68% of all the admitted cases during this period. Late admission was more likely among adults than children (pDengue guidelines in order to standardize the admission criteria and time across hospitals.

  7. Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice.

    Science.gov (United States)

    Wroblewska, Aleksandra; van Haren, Simon D; Herczenik, Eszter; Kaijen, Paul; Ruminska, Aleksandra; Jin, Sheng-Yu; Zheng, X Long; van den Biggelaar, Maartje; ten Brinke, Anja; Meijer, Alexander B; Voorberg, Jan

    2012-05-31

    Development of neutralizing Abs to blood coagulation factor VIII (FVIII) provides a major complication in hemophilia care. In this study we explored whether modulation of the uptake of FVIII by APCs can reduce its intrinsic immunogenicity. Endocytosis of FVIII by professional APCs is significantly blocked by mAb KM33, directed toward the C1 domain of FVIII. We created a C1 domain variant (FVIII-R2090A/K2092A/F2093A), which showed only minimal binding to KM33 and retained its activity as measured by chromogenic assay. FVIII-R2090A/K2092A/F2093A displayed a strongly reduced internalization by human monocyte-derived dendritic cells and macrophages, as well as murine BM-derived dendritic cells. We subsequently investigated the ability of this variant to induce an immune response in FVIII-deficient mice. We show that mice treated with FVIII-R2090A/K2092A/F2093A have significantly lower anti-FVIII Ab titers and FVIII-specific CD4(+) T-cell responses compared with mice treated with wild-type FVIII. These data show that alanine substitutions at positions 2090, 2092, and 2093 reduce the immunogenicity of FVIII. According to our findings we hypothesize that FVIII variants displaying a reduced uptake by APCs provide a novel therapeutic approach to reduce inhibitor development in hemophilia A.

  8. Plasma Measurements of the Fe xvii L-shell Emission and Blending with F viii and F ix

    Science.gov (United States)

    Beiersdorfer, P.; Lepson, J. K.; Gu, M. F.; Bitter, M.

    2017-11-01

    We measured the L-shell emission spectrum of Fe xvii in a low-density, low-gradient magnetically confined laboratory plasma that contains predominately C, O, Fe, and Ni as trace elements and found excellent agreement with the relative spectral emission obtained in solar and astrophysical observations. However, we obtained spectra that appear to have an usually large 1{s}22{s}22{p}1/253{d}3/2\\to 1{s}22{s}22{p}6 Fe xvii resonance transition, which is commonly labeled 3C, from hot plasmas that also contain fluorine. The wavelength of the Lyα feature of F ix is coincident with the wavelength of the Fe xvii line 3C within one part in 538, and its flux, therefore, enhances the Fe xvii resonance line. Moreover, the resonance and forbidden lines of F viii are close to the 3s\\to 2p transitions in Fe xvii and may further alter the inferred apparent Fe xvii line ratios, particularly in spectrometers with moderate spectral resolution. The enhanced emission of line 3C can thus serve as a new spectral diagnostic for the detection of fluorine in astrophysical plasmas.

  9. Budget Management Health System Only - SUS im Municipal Context: Analysis of Audit-SUS in PPA of Fortaleza and its Role in Social Control Strengthening

    Directory of Open Access Journals (Sweden)

    Lizziane Souza Queiroz Franco de Oliveira

    2016-10-01

    Full Text Available The budget planning is the duty of every manager and fundamental for the implementation of key policies such as health. To implement them, it’s necessary to control the provision of these services; hence the importance of the audit. This article intends to, through documentary and bibliographic research, analyzing quantitative and qulitatively budgetary forecasting and execution aimed at audit’s actions - SUS, provideds for PPA/2014-2017 and LOA-2014, both the city of Fortaleza, in order to ascertain whether the municipal management performs its expenditure aimed at encouraging good planning and provide to society an efficient public management and responsive to social control.

  10. Development of nanostructured SUS316L-2%TiC with superior tensile properties

    International Nuclear Information System (INIS)

    Sakamoto, T.; Kurishita, H.; Matsuo, S.; Arakawa, H.; Takahashi, S.; Tsuchida, M.; Kobayashi, S.; Nakai, K.; Terasawa, M.; Yamasaki, T.; Kawai, M.

    2015-01-01

    Structural materials used in radiation environments require radiation tolerance and sufficient mechanical properties in the controlled state. In order to offer SUS316L austenitic stainless steel with the assumed requirements, nanostructured SUS316L with TiC addition of 2% (SUS316L-2TiC) that is capable of exhibiting enhanced tensile ductility and flow strength sufficient for structural applications was fabricated by advanced powder metallurgical methods. The methods include MA (Mechanical Alloying), HIP (Hot Isostatic Pressing), GSMM (Grain boundary Sliding Microstructural Modification) for ductility enhancement, cold rolling at temperatures below M d (the temperature where the martensite phase occurs by plastic deformation) for phase transformation from austenite to martensite and heat treatment for reverse transformation from martensite to austenite. It is shown that the developed SUS316L-2TiC exhibits ultrafine grains with sizes of 90–270 nm, accompanied by TiC precipitates with 20–50 nm in grain interior and 70–110 nm at grain boundaries, yield strengths of 1850 to 900 MPa, tensile strengths of 1920 to 1100 MPa and uniform elongations of 0.6–21%, respectively, depending on the heat treatment temperature after rolling at −196 °C. - Highlights: • Nanostructured SUS316L-2%TiC exhibiting sufficient tensile ductility and strength is developed. • The development requires an advanced powder metallurgical route. • The route includes MA, HIP, GSMM and thermo-mechanical treatments for phase transformation. • The austenite grain sizes are 90–270 nm and TiC precipitates 20–50 nm in grain interior. • The tensile strength are 1100–1920 MPa and uniform elongation 0.6–21%.

  11. Sus scrofa

    Indian Academy of Sciences (India)

    Organization and International Society for Animal Genetics. (FAO-ISAG), are ideal for such studies. There is ... lite loci recommended for diversity studies using primers supplied courtesy of Professor M. Rothschild .... tics (direct count, effective number of alleles, observed and expected heterozygosities) for all of these at 14 ...

  12. The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces.

    Directory of Open Access Journals (Sweden)

    Caileen M Brison

    Full Text Available The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy for hemophilia A patients, or they may spontaneously arise in cases of acquired hemophilia. Porcine factor VIII is an effective therapeutic for hemophilia patients with inhibitor due to its low cross-reactivity; however, the molecular basis for this behavior is poorly understood. In this study, the X-ray crystal structure of the porcine factor VIII C2 domain was determined, and superposition of the human and porcine C2 domains demonstrates that most surface-exposed differences cluster on the face harboring the "non-classical" antibody epitopes. Furthermore, antibody-binding results illustrate that the "classical" 3E6 antibody can bind both the human and porcine C2 domains, although the inhibitory titer to human factor VIII is 41 Bethesda Units (BU/mg IgG versus 0.8 BU/mg IgG to porcine factor VIII, while the non-classical G99 antibody does not bind to the porcine C2 domain nor inhibit porcine factor VIII activity. Further structural analysis of differences between the electrostatic surface potentials suggest that the C2 domain binds to the negatively charged phospholipid surfaces of activated platelets primarily through the 3E6 epitope region. In contrast, the G99 face, which contains residue 2227, should be distal to the membrane surface. Phospholipid binding assays indicate that both porcine and human factor VIII C2 domains bind with comparable affinities, and the human K2227A and K2227E mutants bind to phospholipid surfaces with similar affinities as well. Lastly, the G99 IgG bound to PS-immobilized factor VIII C2 domain with an apparent dissociation constant of 15.5 nM, whereas 3E6 antibody binding to PS-bound C2 domain was not observed.

  13. Deliverable D4.5. Failure Mode and Effect Analysis for 100% waste concrete. SUS-CON

    NARCIS (Netherlands)

    Visser, J.H.M.

    2014-01-01

    On January 1st 2012, the European project SUS-CON has been started: “SUStainable, innovative and energy efficient CONcrete, based on the integration of all waste materials” (grant agreement no: 285463). The SUS-CON project aims at developing new technology routes to integrate waste materials in the

  14. Structure of BT-3984, a member of the SusD/RagB family of nutrient-binding molecules

    International Nuclear Information System (INIS)

    Bakolitsa, Constantina; Xu, Qingping; Rife, Christopher L.; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Carlton, Dennis; Chen, Connie; Chiu, Hsiu-Ju; Clayton, Thomas; Das, Debanu; Deller, Marc C.; Duan, Lian; Ellrott, Kyle; Farr, Carol L.; Feuerhelm, Julie; Grant, Joanna C.; Grzechnik, Anna; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kozbial, Piotr; Krishna, S. Sri; Kumar, Abhinav; Lam, Winnie W.; Marciano, David; McMullan, Daniel; Miller, Mitchell D.; Morse, Andrew T.; Nigoghossian, Edward; Nopakun, Amanda; Okach, Linda; Puckett, Christina; Reyes, Ron; Tien, Henry J.; Trame, Christine B.; Bedem, Henry van den; Weekes, Dana; Hodgson, Keith O.; Wooley, John; Elsliger, Marc-André; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2010-01-01

    The crystal structure of BT-3984, a SusD-family protein, reveals a TPR N-terminal region providing support for a loop-rich C-terminal subdomain and suggests possible interfaces involved in sus complex formation. The crystal structure of the Bacteroides thetaiotaomicron protein BT-3984 was determined to a resolution of 1.7 Å and was the first structure to be determined from the extensive SusD family of polysaccharide-binding proteins. SusD is an essential component of the sus operon that defines the paradigm for glycan utilization in dominant members of the human gut microbiota. Structural analysis of BT-3984 revealed an N-terminal region containing several tetratricopeptide repeats (TPRs), while the signature C-terminal region is less structured and contains extensive loop regions. Sequence and structure analysis of BT-3984 suggests the presence of binding interfaces for other proteins from the polysaccharide-utilization complex

  15. Recruiting and Surveying Catholic Parishes for Cancer Control Initiatives: Lessons Learned From the CRUZA Implementation Study.

    Science.gov (United States)

    Allen, Jennifer D; Tom, Laura S; Leyva, Bryan; Rustan, Sarah; Ospino, Hosffman; Negron, Rosalyn; Torres, Maria Idalí; Galeas, Ana V

    2015-09-01

    We describe activities undertaken to conduct organizational surveys among faith-based organizations in Massachusetts as part of a larger study designed to promote parish-based cancer control programs for Latinos. Catholic parishes located in Massachusetts that provided Spanish-language mass were eligible for study participation. Parishes were identified through diocesan records and online directories. Prior to parish recruitment, we implemented a variety of activities to gain support from Catholic leaders at the diocesan level. We then recruited individual parishes to complete a four-part organizational survey, which assessed (A) parish leadership, (B) financial resources, (C) involvement in Hispanic Ministry, and (D) health and social service offerings. Our goal was to administer each survey component to a parish representatives who could best provide an organizational perspective on the content of each component (e.g., A = pastors, B = business managers, C = Hispanic Ministry leaders, and D = parish nurse or health ministry leader). Here, we present descriptive statistics on recruitment and survey administration processes. Seventy-five percent of eligible parishes responded to the survey and of these, 92% completed all four components. Completed four-part surveys required an average of 16.6 contact attempts. There were an average of 2.1 respondents per site. Pastoral staff were the most frequent respondents (79%), but they also required the most contact attempts (M = 9.3, range = 1-27). While most interviews were completed by phone (71%), one quarter were completed during in-person site visits. We achieved a high survey completion rate among organizational representatives. Our lessons learned may inform efforts to engage and survey faith-based organizations for public health efforts. © 2015 Society for Public Health Education.

  16. Desempenho até a desmama de bezerros Nelore e cruzas com Nelore

    Directory of Open Access Journals (Sweden)

    Cubas Antonio Carlos

    2001-01-01

    Full Text Available Foi analisado o desempenho ponderal pré-desmama de bezerros Nelore (N, Guzerá x N (GN, Red Angus x N (RN e Marchigiana x N (MN, oriundos de um experimento de cruzamentos realizado na Estação Experimental do IAPAR de Paranavaí, nascidos no período de 1985 a 1998, produzidos por meio de inseminação artificial, em duas estações anuais de nascimento (janeiro a abril e julho a dezembro. Foi utilizado o método dos quadrados mínimos para análise de 721 observações de pesos ao nascimento (PNT e 686 de pesos à desmama (PDS e ganho médio diário de peso do nascimento até a desmama (GMD_ND. Para PNT, o efeito de classe de datas julianas com intervalos de dez dias entre classes mostrou-se mais útil para explicar variações de épocas de nascimento do que o mês de nascimento, cuja influência foi muito grande para PDS e GMD_ND. Para as três características avaliadas, houve importante efeito (linear e quadrático da idade da vaca (dias mãe do bezerro, bem como dos efeitos fixos de raça do touro ou grupo genético, ano de nascimento do bezerro e sexo do bezerro. A interação grupo genético x sexo do bezerro foi efeito importante para PNT, PDS e GMD_ND. O efeito aleatório de touro dentro de grupo genético foi importante para PNT, PDS e GMD_ND. As médias dos quadrados mínimos e respectivos erros-padrão, sempre na seqüência N, GN, RN e MN, foram: 28,5 ± 0,38 kg, 29,0 ± 0,44 kg, 29,4 ± 0,46 kg e 31,3 ± 0,47 kg, para PNT; 141,3 ± 1,47 kg, 147,6 ± 1,61 kg, 167,5 ± 1,72 kg e 162,0 ± 1,89 kg, para PDS; 0,510 ± 0,007 kg, 0,540 ± 0,008 kg, 0,627 ± 0,008 kg e 0,583 ± 0,009 kg, para GMD_ND.

  17. Relationship between ABO blood groups and von Willebrand factor, ADAMTS13 and factor VIII in patients undergoing hemodialysis.

    Science.gov (United States)

    Rios, Danyelle R A; Fernandes, Ana Paula; Figueiredo, Roberta C; Guimarães, Daniela A M; Ferreira, Cláudia N; Simões E Silva, Ana C; Carvalho, Maria G; Gomes, Karina B; Dusse, Luci Maria Sant' Ana

    2012-05-01

    Several studies have demonstrated that non-O blood groups subjects present an increased VTE risk as compared to those carrying O blood group. The aim of this study was to investigate the ABO blood groups influence on factor VIII (FVIII) activity, von Willebrand factor (VWF), and ADAMTS13 plasma levels in patients undergoing hemodialysis (HD). Patients undergoing HD (N=195) and 80 healthy subjects (control group) were eligible for this cross-sectional study. The ABO blood group phenotyping was performed by the reverse technique. FVIII activity was measured through coagulometric method, and VWF and ADAMTS13 antigens were assessed by ELISA. FVIII activity and VWF levels were significantly higher and ADAMTS13 levels was decreased in HD patients, as compared to healthy subjects (P blood groups showed a significant increase in FVIII activity (P = 0.001) and VWF levels (P blood group. However, no significant difference was observed in ADAMTS13 levels (P = 0.767). In the control group, increased in FVIII activity (P = 0.001) and VWF levels (P = 0.002) and decreased in ADAMTS13 levels (P = 0.005) were observed in subjects carrying non-O blood groups as compared to carriers of O blood group.Our data confirmed that ABO blood group is an important risk factor for increased procoagulant factors in plasma, as FVIII and VWF. Admitting the possible role of kidneys in ADAMTS13 synthesis or on its metabolism, HD patients were not able to increase ADAMTS13 levels in order to compensate the increase of VWF levels mediated by ABO blood groups. Considering that non-O blood groups constitute a risk factor for thrombosis, it is reasonable to admit that A, B and AB HD patients need a careful and continuous follow-up in order to minimize thrombotic events.

  18. Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS-13 in patients with lung cancer.

    Science.gov (United States)

    Liu, Xia; Chen, Xiaogang; Yang, Jiezuan; Guo, Renyong

    2017-09-01

    Coagulative and fibrinolytic disorders appear to be associated with the development of lung cancer. The aim of the present study was to determine plasma levels of von Willebrand factor (VWF) and a disintegrin and metalloproteinase with a thrombospondin type 1 motif 13 (ADAMTS-13), and factor VIII (FVIII) activity, in association with O and non-O blood groups in patients with lung cancer. Plasma levels of VWF and ADAMTS-13, and FVIII activity were measured in 115 patients with lung cancer and 98 healthy subjects. Phenotyping of the ABO blood groups was also performed for the two groups. Significantly increased VWF levels and FVIII activity, as well as significantly decreased ADAMTS-13 levels, were observed in patients with distant metastasis as compared with those without distant metastasis and the healthy controls. Plasma VWF levels and FVIII activity were significantly increased in subjects with non-O type blood compared with those with type O blood in the two groups. However, a significant decrease in ADAMTS-13 levels was observed only in the control group among those with non-O type blood, compared with those with type O blood. The results of the present study indicate that increased VWF and decreased ADAMTS-13 levels facilitate the invasiveness and metastasis of lung cancer. Non-O blood groups constitute a risk factor for increased VWF and FVIII in plasma. Continued monitoring of VWF and ADAMTS-13 levels, and of FVIII activity in patients with lung cancer with distinct blood groups may help to minimize the incidence of thrombotic events and improve assessment of disease progression.

  19. Storage of factor VIII variants with impaired von Willebrand factor binding in Weibel-Palade bodies in endothelial cells.

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    Maartje van den Biggelaar

    Full Text Available BACKGROUND: Point mutations resulting in reduced factor VIII (FVIII binding to von Willebrand factor (VWF are an important cause of mild/moderate hemophilia A. Treatment includes desmopressin infusion, which concomitantly increases VWF and FVIII plasma levels, apparently from storage pools containing both proteins. The source of these VWF/FVIII co-storage pools and the mechanism of granule biogenesis are not fully understood. METHODOLOGY/PRINCIPAL FINDINGS: We studied intracellular trafficking of FVIII variants implicated in mild/moderate hemophilia A together with VWF in HEK293 cells and primary endothelial cells. The role of VWF binding was addressed using FVIII variants displaying reduced VWF interaction. Binding studies using purified FVIII proteins revealed moderate (Arg2150His, Del2201, Pro2300Ser to severe (Tyr1680Phe, Ser2119Tyr VWF binding defects. Expression studies in HEK293 cells and primary endothelial cells revealed that all FVIII variants were present within VWF-containing organelles. Quantitative studies showed that the relative amount of FVIII storage was independent of various mutations. Substantial amounts of FVIII variants are co-stored in VWF-containing storage organelles, presumably by virtue of their ability to interact with VWF at low pH. CONCLUSIONS: Our data suggest that the potential of FVIII co-storage with VWF is not affected in mild/moderate hemophilia A caused by reduced FVIII/VWF interaction in the circulation. These data support the hypothesis that Weibel-Palade bodies comprise the desmopressin-releasable FVIII storage pool in vivo.

  20. Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy.

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    Brandon K Sack

    Full Text Available The major complication in the treatment of hemophilia A is the development of neutralizing antibodies (inhibitors against factor VIII (FVIII. The current method for eradicating inhibitors, termed immune tolerance induction (ITI, is costly and protracted. Clinical protocols that prevent rather than treat inhibitors are not yet established. Liver-directed gene therapy hopes to achieve long-term correction of the disease while also inducing immune tolerance. We sought to investigate the use of adeno-associated viral (serotype 8 gene transfer to induce tolerance to human B domain deleted FVIII in hemophilia A mice. We administered an AAV8 vector with either human B domain deleted FVIII or a codon-optimized transgene, both under a liver-specific promoter to two strains of hemophilia A mice. Protein therapy or gene therapy was given either alone or in conjunction with anti-CD20 antibody-mediated B cell depletion. Gene therapy with a low-expressing vector resulted in sustained near-therapeutic expression. However, supplementary protein therapy revealed that gene transfer had sensitized mice to hFVIII in a high-responder strain but not in mice of a low-responding strain. This heightened response was ameliorated when gene therapy was delivered with anti-murine CD20 treatment. Transient B cell depletion prevented inhibitor formation in protein therapy, but failed to achieve a sustained hypo-responsiveness. Importantly, use of a codon-optimized hFVIII transgene resulted in sustained therapeutic expression and tolerance without a need for B cell depletion. Therefore, anti-CD20 may be beneficial in preventing vector-induced immune priming to FVIII, but higher levels of liver-restricted expression are preferred for tolerance.

  1. Factor VIII (F8) inversions in severe hemophilia A: Male germ cell origin and diagnosis with RT-PCR

    Energy Technology Data Exchange (ETDEWEB)

    Antonarakis, S.E. [Geneva Medical School (Switzerland)]|[Johns Hopkins School of Medicine, Baltimore, MD (United States); Rossiter, J.P. [Johns Hopkins School of Medicine, Baltimore, MD (United States); Young, M. [Geneva Medical School (Switzerland)] [and others

    1994-09-01

    The Factor VIII (F8) gene, which is defective in hemophilia A, is located in the most telomeric megabase of Xq. Inversions due to intrachromosomal homologous recombination between mispaired copies of gene A located within intron 22 of the gene and about 500 kb telomeric to it account for nearly half of the cases of severe hemophilia A. We hypothesized that pairing of Xq with its homolog inhibits the inversion process, and that therefore the event originates predominantly in male germ cells. In all 21 informative cases in which the inversion originated in a maternal grandparent, DNA polymorphism analysis using markers within or very closely linked to F8, determined that it occurred in the male germline. In addition, all but one of 56 mothers of sporadic cases due to inversions were carriers. The data indicate that the F8 gene inversions leading to severe hemophilia A occur almost exclusively in male germ cells. The mean age of maternal grandfathers at the birth of their carrier daughters was 29.9 years (13 cases), i.e. not different from the mean paternal age in the general population, supporting the hypothesis that the inversions occur in meiosis. The inversions can be diagnosed by Southern blot analysis. For more rapid diagnosis we have used RT-PCR of RNA ectopically expressed in blood. Oligonucleotides were used to PCR amplify, after the initial RT reaction of RNA samples using random hexamers, either the normal transcript (F8 exons 21 to 24;312 bp product) or the novel abnormal transcript that is generated after the inversion. Both type 1 and 2 inversions can be recognized in affecteds and carriers by the presence of the diagnostic PcR product of 248 bp. Correct diagnoses were made in samples from 6 patients and 2 carriers with type 1 inversions, 2 patients and 2 carriers with type 2 inversions and 5 normal controls.

  2. Severe hemophilia A in a female by cryptic translocation: Order and orientation of factor VIII within Xq28

    Energy Technology Data Exchange (ETDEWEB)

    Migeon, B.R.; McGinniss, M.J.; Antonarakis, S.E.; Axelman, J.; Stasiowski, B.A.; Youssoufian, H.; Kearns, W.G.; Chung, A.; Pearson, P.L.; Kazazian, H.H. Jr. (Johns Hopkins Univ., Baltimore, MD (United States)); Muneer, R.S. (Univ. of Oklahoma, Norman (United States))

    1993-04-01

    The authors report studies of a female with severe hemophilia A resulting from a complex de novo translocation of chromosomes X and 17 (46,X,t(X; 17)). Somatic cell hybrids containing the normal X, the der(X), or the der(17) were analyzed for coagulation factor VIII (F8C) sequences using Southern blots and polymerase chain reaction. The normal X, always late replicating, contains a normal F8C gene, whereas the der(X) has no F8C sequences. The der(17) chromosome containing Xq24-Xq28 carries a functional G6PD locus and a deleted F8C allele that lacks exons 1--15. Also, it lacks the DXYS64-X locus, situated between the F8C locus and the Xq telomere. These results indicate that a cryptic breakpoint within Xq28 deleted the 5[prime] end of F8C, but left the more proximal G6PD locus intact on the der(17)chromosome. As the deleted segment includes the 5[prime] half of F8C as well as the subtelomeric DXYS64 locus, F8C must be oriented on the chromosome with its 5[prime] region closest to the telomere. Therefore, the order of these loci is Xcen-G6PD-3[prime]F8C-5[prime]F8C-DXYS64-Xqtel. The analysis of somatic cell hybrids has elucidated the true nature of the F8C mutation in the pro-band, revealing a more complex rearrangement (three chromosomes involved) than that expected from cytogenetic analysis, chromosome painting, and Southern blots. A 900-kb segment within Xq28 has been translocated to another autosome. Hemophilia A in this heterozygous female is due to the decapitation of the F8C gene on the der(17) and inactivation of the intact allele on the normal X. 27 refs., 5 figs., 1 tab.

  3. DAMPAK POSITIF DAN NEGATIF SOSIAL MEDIA TERHADAP PENDIDIKAN AKHLAK ANAK (Studi Kasus di SMP Negeri 2 Kelas VIII Banda Aceh

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    NISA KHAIRUNI

    2016-01-01

    Full Text Available The author examines the positive and negative effects of social media on the moral education of children in school SMPN 2 class VIII Banda Aceh, it is very interesting because of the many children who abuse social media. This work analyzes about the use of social media that have an impact on the moral education of children. The data collected in this study through the work of other literature, researchers also interviewed principals and students as many as 16 students as well as the observation at the school. Based on the analysis that has been done it can be seen the positive and negative impacts of the use of social media to the moral education of children. The positive impact on the social development of the media on moral education of children among children can adapt, socialize with the public and manage a network of friends, and make children easier to accomplish these tasks, while the negative impact of the development of social media to the moral education of children very much of them can make the omission in children so that children are less disciplined and be lazy, makes children easy to cheat the works of others, disrespectful both in dress and speech, often quarrel due to scenes that are as dangerous as scenes of pornography, violence, wars and so forth , as well as making children miss school because they feel more comfortable in the cafe of the study at the school, not only that social media also makes children spend pocket money a child so that the child took the money her parents secretly to access the internet cafe. Therefore, social media can lead education of children.

  4. Most Factor VIII B Domain Missense Mutations Are Unlikely to Be Causative Mutations for Severe Hemophilia A: Implications for Genotyping

    Science.gov (United States)

    Ogata, Kyoichi; Selvaraj, Sundar R; Miao, Hongzhi Z; Pipe, Steven W

    2011-01-01

    Summary Background & Objective The factor VIII (FVIII) B domain shares very little amino acid homology to other known proteins and is not directly necessary for procoagulant activity. Despite this, missense mutations within the B domain have been reported in patients with hemophilia A. Given that the B domain is dispensable for secretion and function of FVIII, we hypothesized that these mutations should not be causative of hemophilia A in these patients. Methods Plasmid vectors containing B domain missense mutations that were reported to be associated with moderate/severe hemophilia A (T751S, D826E, V993L, H1047Y, T1353A, N1441K, L1462P, E1579D, A1591S, P1641L and S1669L) were analyzed for their effect on synthesis and secretion compared to FVIII wild-type (WT) following transient transfection into COS-1 and CHO cells in vitro. Further, H1047Y, N1441K and E1579D mutants were expressed in vivo in a hemophilia A mouse model by hydrodynamic tail-vein injection. Results FVIII activity and antigen levels for all mutants expressed into the conditioned media of COS-1 and CHO cells were similar to FVIII WT. Also, plasma expression of these mutants was similar to FVIII WT in hemophilia A mice. An in vivo tail clip bleeding assay also demonstrated that blood loss from hemophilia A mice expressing FVIII WT, H1047Y, N1441K and E1579D were similar. Conclusion We conclude that most missense mutations within the FVIII B domain would be unlikely to lead to severe hemophilia A and that the majority of such missense mutations represent polymorphisms or non-pathologic mutations. PMID:21645226

  5. Characterization of Adeno-Associated Viral Vector-Mediated Human Factor VIII Gene Therapy in Hemophilia A Mice.

    Science.gov (United States)

    Greig, Jenny A; Wang, Qiang; Reicherter, Amanda L; Chen, Shu-Jen; Hanlon, Alexandra L; Tipper, Christopher H; Clark, K Reed; Wadsworth, Samuel; Wang, Lili; Wilson, James M

    2017-05-01

    Adeno-associated viral (AAV) vectors are promising vehicles for hemophilia gene therapy, with favorable clinical trial data seen in the treatment of hemophilia B. In an effort to optimize the expression of human coagulation factor VIII (hFVIII) for the treatment of hemophilia A, an extensive study was performed with numerous combinations of liver-specific promoter and enhancer elements with a codon-optimized hFVIII transgene. After generating 42 variants of three reduced-size promoters and three small enhancers, transgene cassettes were packaged within a single AAV capsid, AAVrh10, to eliminate performance differences due to the capsid type. Each hFVIII vector was administered to FVIII knockout (KO) mice at a dose of 10 10 genome copies (GC) per mouse. Criteria for distinguishing the performance of the different enhancer/promoter combinations were established prior to the initiation of the studies. These criteria included prominently the level of hFVIII activity (0.12-2.12 IU/mL) and the pattern of development of anti-hFVIII antibodies. In order to evaluate the impact of capsid on hFVIII expression and antibody formation, one of the enhancer and promoter combinations that exhibited high hFVIII immunogenicity was evaluated using AAV8, AAV9, AAVrh10, AAVhu37, and AAVrh64R1 capsids. The capsids subdivided into two groups: those that generated anti-hFVIII antibodies in ≤20% of mice (AAV8 and AAV9), and those that generated anti-hFVIII antibodies in >20% of mice (AAVrh10, AAVhu37, and AAVrh64R1). The results of this study, which entailed extensive vector optimization and in vivo testing, demonstrate the significant impact that transcriptional control elements and capsid can have on vector performance.

  6. Confocal microscopy analysis of native, full length and B-domain deleted coagulation factor VIII trafficking in mammalian cells.

    Science.gov (United States)

    Becker, Sven; Simpson, Jeremy C; Pepperkok, Rainer; Heinz, Stefan; Herder, Christian; Grez, Manuel; Seifried, Erhard; Tonn, Torsten

    2004-07-01

    In mammalian cells, factor VIII (FVIII) secretion depends upon its interaction with chaperones of the endoplasmic reticulum (ER) and requires a unique ATP-dependent step to dissociate aggregates formed within the ER. To further elucidate mechanisms which might account for the inefficient secretion of recombinant FVIII (rFVIII), we have analyzed the pathways of recombinant full length (rFVIII-FL) and B-domain deleted (rFVIII Delta B) FVIII and compared these to the secretion route of native FVIII in primary hepatocytes. Using confocal laser scanning microscopy in combination with a pulse chase of a known secretion marker, we describe the trafficking route of FVIII, which upon release from the ER--where it colocalizes with calnexin--is transported to the Golgi complex in vesicular-tubular transport complexes (VTCs) which could be further identified as being COP I coated. However, a large portion of rFVIII is retained in the ER and additionally in structures which could not be assigned to the ER, Golgi complex or intermediate compartment. Moderate BiP transcription levels indicate that this observed retention of FVIII does not reflect cellular stress due to an overexpression of FVIII-protein in transduced cells. Moreover, a pulse of newly synthesized rFVIII protein is released within 4 hrs, indicating that once rFVIII is released from the ER there is no further limitation to its secretion. Our data provide new details about the secretory route of FVIII, which may ultimately help to identify factors currently limiting the efficient and physiological expression of FVIII in gene therapy and manufacture.

  7. A novel missense mutation in the FGB g. 3354 T>A (p. Y41N), Fibrinogen Caracas VIII

    Science.gov (United States)

    Marchi, Rita; Rojas, Héctor; Meyer, Michael; Castillo, Oscar; De Sáez Ruiz, Arlette; Weisel, John W.

    2012-01-01

    Summary A novel dysfibrinogenemia with a replacement of Tyr by Asn at Bβ41 has been discovered (fibrinogen Caracas VIII). An asymptomatic 39 year-old male was diagnosed as having dysfibrinogenemia due to a mildly prolonged thrombin time (+ 5.8 sec); his fibrinogen concentration was in the low normal range, both by Clauss and gravimetric determination, 1.9 g/l and 2.1 g/l, respectively. The plasma polymerization process was slightly impaired, characterized by a mildly prolonged lag time and a slightly increased final turbidity. Permeation through the patients’ clots was dramatically increased, with the Darcy constant around 4 times greater than that of the control (22 ± 2 ×10−9 cm2 compared to 6 ± 0.5 ×10−9 cm2 in controls). The plasma fibrin structure of the patient, by scanning electron microscopy, featured a mesh composed of thick fibers (148 ± 50 nm vs. 120 ± 31 nm in controls, p<0.05) and larger pores than those of the control fibrin clot. The viscoelastic properties of the clot from the patient were also altered, as the storage modulus (G′, 310 ± 30) was much lower than in the control (831 ± 111) (p ≤ 0.005). The interaction of the fibrin clot with a monolayer of human microvascular endothelial cells, by confocal laser microscopy, revealed that the patients’ fibrin network had less interaction with the cells. These results demonstrate the significance of the amino terminal end of the β chain of fibrin in the polymerization process and its consequences on the clot organization on the surface of endothelial cells. PMID:21301788

  8. El Capitalismo y sus crisis. Se pueden comparar las grandes crisis de 1873, 1929 y 2008?

    Directory of Open Access Journals (Sweden)

    Dominique Plihon

    2015-05-01

    Full Text Available El capitalismo ha generado una amplia serie de crisis, de las cuales se destacan la de 1873, 1929 y 2008 ya que no solo implican el ámbito económico, por lo que se les puede definir como sistémicas. En la presente colaboración se analizan cuáles fueron sus orígenes, mecanismos, agentes y explicaciones y finalmente a que instrumentos se recurrió para hacerles frente. Lo que permite ver sus semejanzas y diferencias, etc., y así tener una perspectiva más amplia de la crisis por la que atraviesa la economía global. Traducción del francés al español por Eugenia Correa para Ola Financiera.

  9. A systematic review of the process of regionalization of Brazil's Unified Health System, SUS.

    Science.gov (United States)

    Mello, Guilherme Arantes; Pereira, Ana Paula Chancharulo de Morais; Uchimura, Liza Yurie Teruya; Iozzi, Fabíola Lana; Demarzo, Marcelo Marcos Piva; Viana, Ana Luiza d'Ávila

    2017-04-01

    This review focuses only on specific studies into the SUS regionalization process, which were based on empirical results and published since 2006, when the SUS was already under the aegis of the Pact for Health framework. It was found that the regionalization process is now underway in all spheres of government, subject to a set of challenges common to the different realities of the country. These include, primarily, that committee-structured entities are valued as spaces for innovation, yet also strive to overcome the bureaucratic and clientelist political culture. Regional governance is further hampered by the fragmentation of the system and, in particular, by the historical deficiency in planning, from the local level to the strategic policies for technology incorporation. The analyses enabled the identification of a culture of broad privilege for political negotiation, to the detriment of planning, as one of the main factors responsible for a vicious circle that sustains technical deficiency in management.

  10. Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility

    DEFF Research Database (Denmark)

    Knop, Filip K; Holst, Jens Juul; Vilsbøll, Tina

    2008-01-01

    , these effects result in hyperglycemia. In 1958, sulfonylurea (SU) was introduced to the market as one of the first oral treatments for T2DM. Since then, the ability of SU to stimulate the release of insulin from pancreatic beta-cells by the closure of ATP-sensitive K+-channels has been employed as one...... of the most widespread treatment options for T2DM. However, SUs are associated with weight gain and a risk of hypoglycemia, and the one-track antidiabetic mechanism of SUs often results in patients being treated with additional antidiabetic drugs. In recent studies, SU has proven to be associated...... with increased beta-cell apoptosis, suggesting that SU may actually accelerate the progressive decrease in beta-cell mass, thereby promoting the need for insulin replacement. In contrast, the newly developed incretin-based therapies for T2DM employ the beta-cell-preserving properties of incretin hormones...

  11. LA CONCILIACIÓN PREPROCESAL EN EL SISTEMA PENAL ACUSATORIO Y SUS PRINCIPALES APORTES

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    Dayana Becerra

    2009-01-01

    Full Text Available La aproximación que se efectúa en el presente estudio, inicia con un acercamiento al concepto de conciliación como mecanismo alternativo de resolución de conflictos, estableciendo los rasgos generales de esta figura; para posteriormente analizar el antecedente inmediato de la conciliación preprocesal en la ley 600 de 2.000, que abrió camino para concederle en materia penal a este mecanismo mayor importancia. Subsiguientemente se profundiza en la conciliación preprocesal consagrada expresamente en la ley 906 de 2004, y se analizan los cambios generados, para así conocer sus características, y determinar sus principales aportes, en el marco del sistema penal acusatorio.

  12. Replacing SUs with incretin-based therapies for type 2 diabetes mellitus

    DEFF Research Database (Denmark)

    Knop, Filip K; Holst, Jens Juul; Vilsbøll, Tina

    2008-01-01

    Type 2 diabetes mellitus (T2DM) is a progressive disease characterized by insulin resistance, a steady decline in glucose-induced insulin secretion (most likely caused by a progressive decrease in functional beta-cell mass), and inappropriately regulated glucagon secretion; in combination......, these effects result in hyperglycemia. In 1958, sulfonylurea (SU) was introduced to the market as one of the first oral treatments for T2DM. Since then, the ability of SU to stimulate the release of insulin from pancreatic beta-cells by the closure of ATP-sensitive K+-channels has been employed as one...... of the most widespread treatment options for T2DM. However, SUs are associated with weight gain and a risk of hypoglycemia, and the one-track antidiabetic mechanism of SUs often results in patients being treated with additional antidiabetic drugs. In recent studies, SU has proven to be associated...

  13. El desarrollo psicomotor y sus alteraciones: entre lo normal y lo patológico

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    Agustina Vericat

    2013-10-01

    Full Text Available El siguiente artículo discute aspectos propios del desarrollo psicomotor (DPM y sus alteraciones, con especial énfasis en el retraso psicomotor. Se hace referencia a las clasificaciones diagnósticas para los problemas del desarrollo como el DSMIV y el CIE 10, y se analizan sus ventajas y desventajas. También se problematiza el concepto de normalidad en tanto sinónimo de promedio estadístico en el contexto de los problemas del DPM, para considerar su dinámica y variabilidad, evitando la oposición normalidad/patología, y valorando aspectos como el sociocultural que permiten repensar la universalidad y la relatividad del DPM.

  14. Representaciones y sus impactos: el caso de los lacandones en la Selva Lacandona

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    Tim Trench

    2005-02-01

    Full Text Available Las representaciones “positivas” de los lacandones les ofrecen ventajas claras a corto plazo, confiriendo cierto capital simbólico y político en sus relaciones con foráneos y en sus diversas luchas, además de variados beneficios económicos. Pero, a final de cuentas, es cuestionable si su imagen como pueblo “originario” y conservacionista “innato” les ayude en el largo plazo, ya que forma parte de un discurso fundamentalmente colonialista y puede limitar las oportunidades de las comunidades lacandonas a decidir su futuro y definir el carácter de su inserción en la sociedad nacional.

  15. Biochemical and Molecular Characterization of RcSUS1, a Cytosolic Sucrose Synthase Phosphorylated in Vivo at Serine 11 in Developing Castor Oil Seeds*

    Science.gov (United States)

    Fedosejevs, Eric T.; Ying, Sheng; Park, Joonho; Anderson, Erin M.; Mullen, Robert T.; She, Yi-Min; Plaxton, William C.

    2014-01-01

    Sucrose synthase (SUS) catalyzes the UDP-dependent cleavage of sucrose into UDP-glucose and fructose and has become an important target for improving seed crops via metabolic engineering. A UDP-specific SUS homotetramer composed of 93-kDa subunits was purified to homogeneity from the triacylglyceride-rich endosperm of developing castor oil seeds (COS) and identified as RcSUS1 by mass spectrometry. RcSUS1 transcripts peaked during early development, whereas levels of SUS activity and immunoreactive 93-kDa SUS polypeptides maximized during mid-development, becoming undetectable in fully mature COS. The cytosolic location of the enzyme was established following transient expression of RcSUS1-enhanced YFP in tobacco suspension cells and fluorescence microscopy. Immunological studies using anti-phosphosite-specific antibodies revealed dynamic and high stoichiometric in vivo phosphorylation of RcSUS1 at its conserved Ser-11 residue during COS development. Incorporation of 32Pi from [γ-32P]ATP into a RcSUS1 peptide substrate, alongside a phosphosite-specific ELISA assay, established the presence of calcium-dependent RcSUS1 (Ser-11) kinase activity. Approximately 10% of RcSUS1 was associated with COS microsomal membranes and was hypophosphorylated relative to the remainder of RcSUS1 that partitioned into the soluble, cytosolic fraction. Elimination of sucrose supply caused by excision of intact pods of developing COS abolished RcSUS1 transcription while triggering the progressive dephosphorylation of RcSUS1 in planta. This did not influence the proportion of RcSUS1 associated with microsomal membranes but instead correlated with a subsequent marked decline in SUS activity and immunoreactive RcSUS1 polypeptides. Phosphorylation at Ser-11 appears to protect RcSUS1 from proteolysis, rather than influence its kinetic properties or partitioning between the soluble cytosol and microsomal membranes. PMID:25313400

  16. La cuenca del Río Pardo (Brasil y sus estrategias de desarrollo rural sostenible

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    Wanderleia Elizabeth Brinckmann

    2002-01-01

    Full Text Available La finalidad del presente artículo consiste en estudiar el cuadro socioeconómico y ambiental de la agricultura familiar en la Cuenca Hidrográfica del Río Pardo, Brasil. Se busca analizar la producción agroecológica, sus dificultades y potencialidades. El análisis se refiere a las estrategias de desarrollo rural sostenible en curso en la Cuenca Hidrográfica del Río Pardo.

  17. REINO, POLÍTICA Y MISIÓN. SUS RELACIONES EN PERSPECTIVA LATINOAMERICANA (RESEÑA

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    Hilario Wynarzcyk

    2012-06-01

    Full Text Available Recientemente ha sido salido el libro “Reino, política y misión, sus relaciones en perspectiva latinoamericana”, escrito por Alberto Roldán y publicado por Ediciones Puma, sello del Centro de Investigaciones y Publicaciones(CENIP, de Lima, Perú. El autor es argentino, profesor de teología en la ciudad de Buenos Aires.

  18. Serologic survey of the wild boar (Sus scrofa) for Borrelia burgdorferi sensu lato

    Czech Academy of Sciences Publication Activity Database

    Juřicová, Zina; Hubálek, Zdeněk

    2009-01-01

    Roč. 9, č. 5 (2009), s. 479-482 ISSN 1530-3667 R&D Projects: GA ČR GA524/96/1059 EU Projects: European Commission(XE) 10284 - EDEN Institutional research plan: CEZ:AV0Z60930519 Keywords : Borrelia burgdorferi * Sus scrofa * serosurvey * Czech Republic Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 2.607, year: 2009

  19. Uso de derivados de quinazollnas y sus composiciones farmacéuticas en enfermedades neurodegenerativas

    OpenAIRE

    Martínez, Ana; Redondo, Miriam; Sanz-SanCristóbal, Marina; Gil, Carmen; Morales-García, José A.; Pérez Castillo, Ana; Pérez Martín, María Concepción

    2009-01-01

    Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas. La invención se refiere a derivados heterocíclicos de quinazolinas y a su potencial para el tratamiento de enfermedades neurodegenerativas y/o neurológicas, entre otras la enfermedad de Parkinson, enfermedad de Alzheimer o esclerosis. Además, la invención se refiere a composiciones farmacéuticas que comprenden dichos compuestos derivados de quinazolinas.

  20. Necesidades sanitarias de las personas con discapacidad intelectual y sus familias

    OpenAIRE

    Muñoz, J.

    2005-01-01

    La salud es un derecho humano fundamental. Las personas con discapacidad intelectual y sus familias afrontan una gran cantidad de barreras cuando acceden a los servicios sanitarios. La falta de acceso a estos servicios coloca a las personas con discapacidad intelectual en serias desventajas sociales. Las barreras que las personas con discapacidad intelectual encuentran en los servicios sanitarios les hacen más vulnerables a la enfermedad. Los profesionales de los hospitales y centros de salud...

  1. A homeopatia no SUS na perspectiva de estudantes da área da saúde

    Directory of Open Access Journals (Sweden)

    Gecioni Loch-Neckel

    Full Text Available A homeopatia foi reconhecida como especialidade médica em 1980. Após a criação do SUS, alguns estados e municípios brasileiros começaram a oferecer atendimento homeopático aos usuários dos serviços públicos de saúde. Em 2006, foi editada a Portaria 971, que assegura o acesso à homeopatia a estes usuários, entre outras práticas integrativas e complementares. Diante disto, investigamos as percepções de estudantes dos cursos de Farmácia, Medicina e Odontologia sobre a homeopatia e sua prática no SUS, tendo por fundamento a teoria das representações sociais. Estas representações foram construídas com os seguintes parâmetros: a homeopatia como terapêutica; a relação entre a homeopatia, o SUS e o princípio da integralidade. Os estudantes souberam correlacionar o atendimento integral ao sujeito à compreensão de suas necessidades a partir de sua realidade. Constatou-se desconhecimento sobre os pressupostos teóricos da homeopatia e o não reconhecimento da incorporação da homeopatia no SUS, para a maioria dos estudantes. Pode ser sugerido que a inserção dos futuros profissionais no contexto das atividades em saúde e o acesso a outras racionalidades permitiriam uma escolha mais lúcida de suas práticas profissionais.

  2. SUS in nuclear medicine in Brazil: analysis and comparison of data provided by Datasus and CNEN.

    Science.gov (United States)

    Pozzo, Lorena; Coura Filho, George; Osso Júnior, João Alberto; Squair, Peterson Lima

    2014-01-01

    To investigate the outpatient access to nuclear medicine procedures by means of the Brazilian Unified Health System (SUS), analyzing the correspondence between data provided by this system and those from Comissão Nacional de Energia Nuclear (CNEN) (National Commission of Nuclear Energy). Data provided by Datasus regarding number of scintillation chambers, outpatient procedures performed from 2008 to 2012, administrative responsibility for such procedures, type of service providers and outsourced services were retrieved and evaluated. Also, such data were compared with those from institutions certified by CNEN. The present study demonstrated that the system still lacks maturity in terms of correct data input, particularly regarding equipment available. It was possible to list the most common procedures and check the growth of the specialty along the study period. Private centers are responsible for most of the procedures covered and reimbursed by SUS. However, many healthcare facilities are not certified by CNEN. Datasus provides relevant data for analysis as done in the present study, although some issues still require attention. The present study has quantitatively depicted the Brazilian reality regarding access to nuclear medicine procedures offered by/for SUS.

  3. Healthcare regions and their care networks: an organizational-systemic model for SUS.

    Science.gov (United States)

    Santos, Lenir

    2017-04-01

    This paper describes a comprehensive effort to develop studies regarding Brazil's Unified Healthcare System (SUS), as a result of the combination of public services in a network that follows a region-based rationale (tripartite organization). The SUS emerges from such an integration and should be organized as such. The intention is to demonstrate that this type of organization is essential, given that Brazil is organized as a Federation, and all three governmental levels are, in a broad sense, equally responsible for healthcare. Healthcare services and actions are a complex set of activities that are interconnected on behalf of citizen health, which is a global concept that cannot be split up. Services must follow this rationale and be organized as such. Thus, healthcare services must be systematically organized to serve everyone equally, regardless of where a citizen lives. This systemic organization requires permanent interaction between federative units to discuss and operationalize reference services, funding and other technical and administrative aspects. These are the essential elements that make the SUS so complex and demand it be organized regionally, as a network of healthcare services.

  4. De las perturbadoras y conflictivas relaciones de los bogotanos con sus aguas

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    Ana María Carreira

    2007-01-01

    Full Text Available el propósito de este texto es dar cuenta de la desligación entre el ser y su estar, manifestado históricamente en la ciudad de Bogotá desde su fundación en 1538 hasta nuestros días. Las aguas son parte de ese estar en el territorio y genera formas de ser. La indiferencia y el abandono de los ríos expresado a través de la contaminación, entubamiento, y sus consecuencias: inundaciones, olores fétidos, desbordes, escasez, son imágenes que no contribuyen a construir ese ser a partir del estar en el territorio. Para rastrear esta desligación entre los bogotanos y sus cuarenta y nueve corrientes de agua, presentamos los momentos claves de esta relación, desde la concepción poética del agua que crearon los primeros habitantes de la sabana, el quiebre sufrido con la fundación de la ciudad y el inicio de un proceso donde el agua se asume como recurso, prevaleciendo el interés por explotarla. De este modo, Bogotá no ha desarrollado sus atributos estéticos y espirituales, y ha ido tras imágenes y modelos extraños a su territorio.

  5. Microstructures and Mechanical Properties of Austempering SUS440 Steel Thin Plates

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    Cheng-Yi Chen

    2016-02-01

    Full Text Available SUS440 is a high-carbon stainless steel, and its martensite matrix has high heat resistance, high corrosion resistance, and high pressure resistance. It has been widely used in mechanical parts and critical materials. However, the SUS440 martempered matrix has reliability problems in thin plate applications and thus research uses different austempering heat treatments (tempering temperature: 200 °C–400 °C to obtain a matrix containing bainite, retained austenite, martensite, and the M7C3 phase to investigate the relationships between the resulting microstructure and tensile mechanical properties. Experimental data showed that the austempering conditions of the specimen affected the volume fraction of phases and distribution of carbides. After austenitizing heat treatment (1080 °C for 30 min, the austempering of the SUS440 thin plates was carried out at a salt-bath temperature 300 °C for 120 min and water quenching was then used to obtain the bainite matrix with fine carbides, with the resulting material having a higher tensile fracture strength and average hardness (HRA 76 makes it suitable for use as a high-strength thin plate for industrial applications.

  6. EL PROTESTANTISMO COLOMBIANO: SUS ORÍGENES, LUCHAS Y EXPANSIÓN (1856-1991

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    Helwar Hernando Figueroa S.

    2016-09-01

    Full Text Available Los protestantes en sus múltiples denominaciones se han convertido en la segunda fuerza religiosa de Colombia gracias a su permanente proselitismo mediático y a su presencia en todos los escenarios sociales y políticos del país, un crecimiento que terminó por disputarle fieles al catolicismo tradicionalista. Con el ánimo de comprender su expansión y subdivisiones en la revisión historiográfica,se buscó describir y analizar el proceso histórico por medio del cual los protestantes en todas sus denominaciones lograron ampliar el campo religioso colombiano. Para ello,se consideró oportuno hacer una síntesis histórica, y en su narración explicar los principales conceptos que intentan definir el campo protestante. La investigación se basó en una revisión exhaustiva de la bibliografía existente sobre el protestantismo en Colombia y en una revisión documental sobre lo escrito por los protestantes y sus contradictores católicos. En las conclusiones se insiste en afirmar que los protestantes lograron crecer exponencialmente gracias a su fragmentación y posterior conformación en iglesias nacionales de talante carismático y pentecostal.

  7. [Whose is SUS? About the social representation of the users of the Family Health Program].

    Science.gov (United States)

    Martins, Poliana Cardoso; Cotta, Rosângela Minardi Mitre; Mendes, Fábio Farias; Priore, Silvia Eloiza; Franceschinni, Sylvia do Carmo Castro; Cazal, Mariana de Melo; Batista, Rodrigo Siqueira

    2011-03-01

    The present study analyzes the representation of the users of SUS and PSF, presenting data obtained by semi-structured interviews, using the theoretical referential of the qualitative research. The results show a social representation marked by a focused vision and assistance, pointing to the concentration of public resources in poor segments of the society and centered in the biomedical model of attention. It stands out that PSF did not reach their objectives to provide changes in the praxis in health. In relation to the social control, it is observed that only 5.9% of the interviewees know the CMS. The presented data show a great ignorance by the studied population on the sanitary system and conquered social laws, and many people still see SUS as a "health plan for the poor". Due to the lived reality, the need of the implementation of strategies is emphasized for the reach of larger powerment/liberation of the population, seeking to build effective possibilities so that their actors will be active participant of the process of construction of a common project, actually based on the democratic ideals of SUS, being PSF strategically important in the accomplishment of these actions.

  8. Los consejos escolares de los colegios de educación primaria analizados por sus miembros

    Directory of Open Access Journals (Sweden)

    José Fernando González Granda

    2004-01-01

    Full Text Available En este trabajo presentamos la valoración que de los consejos escolares de los colegios de educación primaria de la Comunidad Autónoma de Asturias realizan sus miembros. Se analizan las principales características de los consejeros así como la información y atención que éstos prestan a sus representados. Se valora el funcionamiento de los consejos y cómo cumplen éstos las competencias que tienen asignadas. También recogemos la valoración que los consejeros realizan de los problemas que tienen en el cumplimiento de sus tareas. Los consejeros valoran cómo los consejos mejoran el funcionamiento de los colegios y diversos aspectos relacionados con la participación, asi como la satisfacción de los distintos miembros de la comunidad escolar respecto al funcionamiento de los consejos escolares.

  9. Representaciones sobre la Patagonia y sus habitantes originarios en los textos escolares. 1886-1940

    Directory of Open Access Journals (Sweden)

    Mirta Teobaldo

    2007-01-01

    Full Text Available La Patagonia, como tierra mítica, y sus habitantes originarios, han sido objeto de diferentes estudios. Sin embargo, su representación a través de los libros de texto es tema escasamente estudiado. En base a un corpus de catorce libros de textos, correspondientes a las escue- las del Estado y a las escuelas de la Congregación salesiana, nos pro- ponemos analizar dos representaciones específicas sobre el indígena patagónico: 1 el indígena como “salvaje” y “enemigo de la civiliza- ción” en un espacio “vacío” y “desierto” y 2 el indígena “paleontolo- gizado” y ahistórico, en un espacio natural con potencial productivo. Las representaciones están vinculadas a dos ideas relacionadas con las políticas del Estado sobre la Patagonia: una con el plano territorial: la idea de “desierto” y “vacío” y la otra, con el plano de sus habitantes: la idea de “salvajismo” y “barbarie”; ideas que legitiman la conquista y el exterminio de sus habitantes originarios. En los textos escolares la transposición didáctica operó yuxtaponiendo nuestras categorías de análisis.

  10. [Integral care, a SUS (Brazilian Unified Health System) guideline for the sanitary surveillance].

    Science.gov (United States)

    O'Dwyer, Gisele; Reis, Daniela Carla de Souza; da Silva, Luciana Leite Gonçalves

    2010-11-01

    The sanitary surveillance (Visa) performs several practices, on different objects and its actions are guided by principles and guidelines of the SUS. It was done a critical reflection on the interaction conditions of practice in Visa, with a constitutional proposition of the SUS: integral care. The analysis was based on the theory of structuration (Giddens) that considers mobilization of structural resources as dimensions of social interaction, which would justify the legitimacy exercised since the standards. Have been analyzed the following categories: Visa and its insertion within the SUS; the integral care and the Visa; and political impediments. The Visa has been organized by National Health Surveillance Agency. Nowadays it has as sanitary responsibilities, communication with society and health promotion. The proposal of the literature concerning integral care is based on the assistance issue. The organization of the services in the different federative entities is the sense of integral care most adopted by Visa. Political impediments focus on the institutional renewal, on the conflicts of interest arena, on the distance between formulated policies and established practices and gaps concerning work management and the insufficiency of financial support.

  11. UN PRIVILEGIO PARA EL ESTADO DE MICHOACÁN: SUS PUEBLOS MÁGICOS

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    Horacio Mercado Vargas

    2013-06-01

    Full Text Available El Estado de Michoacán, que se ubica en la parte del extremo sur occidental de México, posee paisajes muy hermosos: de bosques, praderas y lagunas de gran belleza, montañas y volcanes que descienden hacia el mar. Es uno de los más ricos en recursos naturales. La Secretaría de Turismo, diversas entidades del gobierno federal y gobiernos estatales y municipales desarrollaron el Programa de Pueblos Mágicos, para darle un valor a ciertas poblaciones del país que tienen características culturales y que llaman la atención de los visitantes mexicanos y extranjeros. Michoacán es una entidad que por sus características culturales, se distingue del resto de las entidades, y por ello es el estado con mayor número de Pueblos Mágicos en todo el país. La belleza y cultura de Michoacán se puede constatar en sus Pueblos Mágicos, que siempre recordarán los visitantes. Sus formas, colores y tradiciones son expresiones de un pasado lleno de gloria que se manifiesta en el presente.

  12. A Religiosidade/Espiritualidade dos Médicos de Família: Avaliação de Alunos da Universidade Aberta do SUS (UNA-SUS

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    Paulo Rogerio Aguiar

    Full Text Available RESUMO Introdução Muitas universidades ao redor do mundo têm incluído o tema religiosidade/espiritualidade (R/E no currículo médico no período de graduação, especialmente nos Estados Unidos e Reino Unido. Este artigo objetiva apresentar a opinião de médicos, especializandos em Saúde da Família da Universidade Aberta do SUS (UNA-SUS na Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA sobre o ensino do tema R/E na graduação em Medicina, as percepções dos profissionais sobre essa temática na prática clínica e os índices de religiosidade/espiritualidade dos estudantes. Metodologia Estudo transversal, em que um instrumento de pesquisa eletrônica foi disponibilizado aos alunos na plataforma virtual da UNA-SUS/UFCSPA, tendo sido convidados a participar voluntariamente todos os médicos de nacionalidade brasileira inscritos no curso de especialização em Saúde da Família entre os meses de junho e agosto de 2016. Resultados Foram obtidas 73 respostas (17,2% de um total de 423 médicos. Foram encontrados 61,4% de católicos, 18,5% de evangélicos e 8,6% de espíritas, sendo 52,1% de não praticantes; 86,3% acreditam em Deus; 89% consideram importante ou muito importante o cuidado espiritual nas práticas em saúde e 94,6% consideram que a espiritualidade contribui para a saúde física. Constatou-se que 60,3% consideram a coleta da história espiritual como a habilidade mais importante a ser aprendida e 72,2% concordam em que o tema R/E deve ser abordado na graduação, enquanto 13,7% relataram contato prévio com o tema na faculdade. A relevância conferida à R/E no cuidado médico não parece ter sido mediada pela religiosidade intrínseca dos estudantes, pois não houve correlação estatisticamente significativa entre essa variável e a atribuição de importância à R/E na prática clínica (p = 0,585. Os médicos avaliados parecem reconhecer a importância da espiritualidade para os pacientes e para a sa

  13. Acupuntura no Sistema Único de Saúde e a inserção de profissionais não-médicos Acupuncture in the Brazilian National Health System (SUS and the inclusion of non-medical professionals

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    FAS Santos

    2009-08-01

    Full Text Available CONTEXTUALIZAÇÃO: Desde o relatório final da VIII Conferência Nacional de Saúde em 1986, busca-se a introdução de práticas alternativas de assistência à saúde no âmbito dos serviços públicos de saúde. Porém, apenas em 2006, por meio da Política Nacional de Práticas Integrativas e Complementares, os profissionais não-médicos puderam atuar como acupunturistas no Sistema Único de Saúde (SUS. OBJETIVOS: Descrever a evolução da acupuntura no SUS bem como a inclusão de novos acupunturistas não-médicos. MÉTODOS: Efetuou-se um estudo exploratório e descritivo cuja fonte de dados foi o Sistema de Informações Ambulatoriais (SIA do SUS, disponibilizado pelo banco de dados do Ministério da Saúde, relativo às consultas em acupuntura realizadas por médicos e não-médicos entre 1999 e 2007, distribuindo-se os atendimentos segundo cidades e ano do atendimento. Para a análise da tendência temporal do número de atendimentos de acupuntura, foi utilizado o modelo de regressão linear simples, utilizando-se nível de significância de 5%. RESULTADOS: A análise da tendência temporal revelou um aumento significativo (p>0,001 de 1,1 consultas em acupuntura por 100 mil atendimentos ambulatoriais anualmente registrados entre os anos de 1999 e 2007. Foi observado um expressivo incremento no último ano do período estudado. Em 2007, 28% das consultas de acupuntura foram registradas por profissionais não-médicos em 41 cidades. CONCLUSÕES: Há expansão das consultas e do número de cidades que registram acupuntura no SUS no período do estudo.BACKGROUND: Since the final report of the 8th National Health Conference in 1986, the introduction of alternative healthcare practices within the scope of public health services has been sought. However, it was only in 2006, through the National Policy for Complementary and Integrative Practices, that non-medical professionals were allowed to act as acupuncturists within the Brazilian

  14. Uma análise da progressividade do financiamento do Sistema Único de Saúde (SUS

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    Ugá Maria Alicia Domínguez

    2006-01-01

    Full Text Available Este artigo analisa o grau de progressividade dos tributos que financiam o Sistema Único de Saúde (SUS. Nele são identificados os principais tributos que financiam o SUS e, com base nos microdados da Pesquisa de Orçamentos Familiares 2002-2003, é inferida a distribuição do ônus do pagamento dos tributos diretos e indiretos que financiam o SUS e analisado o grau de progressividade dos mesmos. Foi, ainda, calculado o índice de Kakwani do financiamento do SUS, que sintetiza o grau de progressividade de um sistema tributário. Os dados mostraram que o índice de Kakwani do financiamento público é de -0,008 e que, portanto, o financiamento do SUS corresponde a um sistema quase proporcional, que onera proporcionalmente à renda. Em uma sociedade com o grau de desigualdade da brasileira, que exibe um índice de Gini de 0,57, ter um financiamento do SUS proporcional é fortemente questionável sob a ótica da justiça social: ao contrário, seria desejável construir bases de financiamento do SUS francamente progressivas, de forma a contra-restar a fortíssima concentração de renda da nossa sociedade.

  15. Uma análise da progressividade do financiamento do Sistema Único de Saúde (SUS

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    Maria Alicia Domínguez Ugá

    2006-08-01

    Full Text Available Este artigo analisa o grau de progressividade dos tributos que financiam o Sistema Único de Saúde (SUS. Nele são identificados os principais tributos que financiam o SUS e, com base nos microdados da Pesquisa de Orçamentos Familiares 2002-2003, é inferida a distribuição do ônus do pagamento dos tributos diretos e indiretos que financiam o SUS e analisado o grau de progressividade dos mesmos. Foi, ainda, calculado o índice de Kakwani do financiamento do SUS, que sintetiza o grau de progressividade de um sistema tributário. Os dados mostraram que o índice de Kakwani do financiamento público é de ­0,008 e que, portanto, o financiamento do SUS corresponde a um sistema quase proporcional, que onera proporcionalmente à renda. Em uma sociedade com o grau de desigualdade da brasileira, que exibe um índice de Gini de 0,57, ter um financiamento do SUS proporcional é fortemente questionável sob a ótica da justiça social: ao contrário, seria desejável construir bases de financiamento do SUS francamente progressivas, de forma a contra-restar a fortíssima concentração de renda da nossa sociedade.

  16. Plasmid pEC156, a Naturally Occurring Escherichia coli Genetic Element That Carries Genes of the EcoVIII Restriction-Modification System, Is Mobilizable among Enterobacteria.

    Science.gov (United States)

    Werbowy, Olesia; Kaczorowski, Tadeusz

    2016-01-01

    Type II restriction-modification systems are ubiquitous in prokaryotes. Some of them are present in naturally occurring plasmids, which may facilitate the spread of these systems in bacterial populations by horizontal gene transfer. However, little is known about the routes of their dissemination. As a model to study this, we have chosen an Escherichia coli natural plasmid pEC156 that carries the EcoVIII restriction modification system. The presence of this system as well as the cis-acting cer site involved in resolution of plasmid multimers determines the stable maintenance of pEC156 not only in Escherichia coli but also in other enterobacteria. We have shown that due to the presence of oriT-type F and oriT-type R64 loci it is possible to mobilize pEC156 by conjugative plasmids (F and R64, respectively). The highest mobilization frequency was observed when pEC156-derivatives were transferred between Escherichia coli strains, Enterobacter cloacae and Citrobacter freundii representing coliform bacteria. We found that a pEC156-derivative with a functional EcoVIII restriction-modification system was mobilized in enterobacteria at a frequency lower than a plasmid lacking this system. In addition, we found that bacteria that possess the EcoVIII restriction-modification system can efficiently release plasmid content to the environment. We have shown that E. coli cells can be naturally transformed with pEC156-derivatives, however, with low efficiency. The transformation protocol employed neither involved chemical agents (e.g. CaCl2) nor temperature shift which could induce plasmid DNA uptake.

  17. Plasmid pEC156, a Naturally Occurring Escherichia coli Genetic Element That Carries Genes of the EcoVIII Restriction-Modification System, Is Mobilizable among Enterobacteria

    Science.gov (United States)

    Werbowy, Olesia; Kaczorowski, Tadeusz

    2016-01-01

    Type II restriction-modification systems are ubiquitous in prokaryotes. Some of them are present in naturally occurring plasmids, which may facilitate the spread of these systems in bacterial populations by horizontal gene transfer. However, little is known about the routes of their dissemination. As a model to study this, we have chosen an Escherichia coli natural plasmid pEC156 that carries the EcoVIII restriction modification system. The presence of this system as well as the cis-acting cer site involved in resolution of plasmid multimers determines the stable maintenance of pEC156 not only in Escherichia coli but also in other enterobacteria. We have shown that due to the presence of oriT-type F and oriT-type R64 loci it is possible to mobilize pEC156 by conjugative plasmids (F and R64, respectively). The highest mobilization frequency was observed when pEC156-derivatives were transferred between Escherichia coli strains, Enterobacter cloacae and Citrobacter freundii representing coliform bacteria. We found that a pEC156-derivative with a functional EcoVIII restriction-modification system was mobilized in enterobacteria at a frequency lower than a plasmid lacking this system. In addition, we found that bacteria that possess the EcoVIII restriction-modification system can efficiently release plasmid content to the environment. We have shown that E. coli cells can be naturally transformed with pEC156-derivatives, however, with low efficiency. The transformation protocol employed neither involved chemical agents (e.g. CaCl2) nor temperature shift which could induce plasmid DNA uptake. PMID:26848973

  18. Plasmid pEC156, a Naturally Occurring Escherichia coli Genetic Element That Carries Genes of the EcoVIII Restriction-Modification System, Is Mobilizable among Enterobacteria.

    Directory of Open Access Journals (Sweden)

    Olesia Werbowy

    Full Text Available Type II restriction-modification systems are ubiquitous in prokaryotes. Some of them are present in naturally occurring plasmids, which may facilitate the spread of these systems in bacterial populations by horizontal gene transfer. However, little is known about the routes of their dissemination. As a model to study this, we have chosen an Escherichia coli natural plasmid pEC156 that carries the EcoVIII restriction modification system. The presence of this system as well as the cis-acting cer site involved in resolution of plasmid multimers determines the stable maintenance of pEC156 not only in Escherichia coli but also in other enterobacteria. We have shown that due to the presence of oriT-type F and oriT-type R64 loci it is possible to mobilize pEC156 by conjugative plasmids (F and R64, respectively. The highest mobilization frequency was observed when pEC156-derivatives were transferred between Escherichia coli strains, Enterobacter cloacae and Citrobacter freundii representing coliform bacteria. We found that a pEC156-derivative with a functional EcoVIII restriction-modification system was mobilized in enterobacteria at a frequency lower than a plasmid lacking this system. In addition, we found that bacteria that possess the EcoVIII restriction-modification system can efficiently release plasmid content to the environment. We have shown that E. coli cells can be naturally transformed with pEC156-derivatives, however, with low efficiency. The transformation protocol employed neither involved chemical agents (e.g. CaCl2 nor temperature shift which could induce plasmid DNA uptake.

  19. Estudo citofotométrico da expressão do marcador tumoral Fator VIII e fatores prognósticos no adenocarcinoma gástrico Cytophotometric study of the expression of the tumoral marker Factor VIII and prognostic factors in gastrci adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Mary Tossa Nakamura

    2007-12-01

    Full Text Available RACIONAL: No câncer gástrico, a incidência, o diagnóstico e as opções terapêuticas apresentaram melhorias nas últimas décadas, porém o prognóstico permanece reservado, especialmente devido à maioria dos pacientes procurarem recurso médico com tumores avançados, metastáticos ou cirurgicamente irressecáveis já no diagnóstico. Biologia molecular é área de conhecimento recente com grandes questionamentos a serem respondidos e a atualidade dos fatos científicos mostra que o caminho deverá ser através da identificação de marcadores tumorais. Os grandes avanços na área da informática aprimoraram a análise da imagem celular através da citofotometria de imagem que possibilita através da imunoistoquímica estudar a proliferação celular e a angiogênese que participa em diversos processos tumorais, sendo pesquisadas por vários marcadores. Atualmente estudos são realizados para demonstrar o valor prognóstico de suas expressões, contudo, no adenocarcinoma gástrico resultados têm sido divergentes e estudos escassos. OBJETIVOS: Identificar e quantificar citofotometricamente a expressão dos marcadores da angiogênese através do fator VIII no adenocarcinoma e comparar suas expressões com fa classificação de Bormann, profundidade de invasão tumoral, grau de diferenciação, envolvimento nodal, padrão histológico e idade. MÉTODOS: Foram estudados 21 pacientes com adenocarcinoma gástrico, identificados de 1998 a 2006. Para a detecção do Fator VIII foi realizada imunoistoquímica, com anticorpo policlonal para Fator VIII. Foi realizada análise citofotométrica informatizada pelo sistema SAMBA 4000. RESULTADOS: Dos 21 pacientes 61,90% eram do sexo masculino e 38,10% do feminino, com idade mediana de 65 anos e apenas um não marcou para o Fator VIII (95,24% de marcação. As médias dos índices de marcagem para o Fator VIII foram de 61,14% (desvio-padrão de 15,06, variando de 29,16 a 73,91. Tumores com classifica

  20. Expressão citofotométrica dos marcadores tumorais CD-34 e fator VIII no câncer de cólon

    OpenAIRE

    Garcia,Cacilda Joyce Ferreira da Silva; Cuenca,Ronaldo M.; Bora,Fabio Roberto; Ribas-Filho,Jurandir Marcondes; Czeczko,Nicolau Gregori; Ribas,Carmen Austrália Paredes Marcondes; Wagenführ Jr.,Jorge

    2009-01-01

    OBJETIVOS: Verificar a posssibilidade de quantificar a expressão dos marcadores tumorais CD-34 e Fator VIII no câncer de cólon; verificar se existe superioridade entre um marcador e outro para estudo da angiogênese; verificar se há correlação na análise do índice de marcagem e a densidade óptica média nos marcadores utilizados. MÉTODOS: Dezessete casos de adenocarcinoma colorretal recuperados de blocos de parafina e confirmados pela hematoxilina-eosina, foram submetidos à coloração imunoistoq...

  1. Liquid-liquid extraction and separation of VIII group elements, especially ruthenium, by synergic combinations or aromatic polyimines and micellar cationic exchangers

    International Nuclear Information System (INIS)

    Vitart, X.

    1991-01-01

    This thesis aims to characterize and to quantify the chemical equilibria involved in d-elements liquid-liquid extraction systems, especially elements belonging to the VIII group (Fe, Ni, Co, Ru, Rh, Pd, Pt). These systems are composed of synergic combination of aromatic polyimines and micellar cationic exchangers. Substitutions are first performed in aqueous acidic media by aromatic polyimines; then extractions are operated using micellic canionic exchangers. Chemical equilibria, selectivity effects, especially those due to ion-pair formations, kinetics, extractant behaviour are analysed and quantified [fr

  2. Specific analysis of the intron 22 XbaI polymorphism of the human factor VIII gene using long-distance PCR.

    Science.gov (United States)

    De Brasi, C D; Bowen, D J; Collins, P W; Larripa, I B

    1999-12-01

    A rapid, non-radioactive, PCR-based method to genotype the XbaI restriction fragment length polymorphism of the human factor VIII gene is described. The method uses long-distance PCR followed by XbaI restriction digestion and agarose gel electrophoresis. The 6.6 kb amplification product includes a constant XbaI site, which provides a digestion control. The specificity of the method was challenged by a blind experiment with 16 genomic DNA samples previously genotyped by Southern blot analysis: a perfect correlation was obtained between genotypes determined using Southern blot and PCR.

  3. Pathogen inactivation in fresh frozen plasma using riboflavin and ultraviolet light: Effects on plasma proteins and coagulation factor VIII

    Directory of Open Access Journals (Sweden)

    Stanojković Zoran

    2011-01-01

    Full Text Available Background/Aim. Riboflavin (vitamin B2 activated by ultraviolet (UV light, produces active oxygen which damages cell membrane and prevents replication of the carrier of diseases (viruses, bacteria, protozoa in all blood products. The aim of this study was to establish the influence of the process of photo inactivation in pathogens using riboflavin and UV rays on the concentration of coagulation factor VIII:C (FVIII:C and proteins in plasma that were treated before freezing. Methods. The examination included 20 units of plasma, separated from whole blood donated by voluntary blood donors around 6 hours from the moment of collection. The units were pooled and separated in to two groups: one consisted of 10 control units and the other of 10 experimental units. Experimental units of the plasma were treated by riboflavin (35 mL and UV rays (6.24 J/mL, 265-370 nm on Mirasol aparature (Caridian BCT Biotechnologies, USA in approximate duration of 6 minutes. Furthermore, 35 mL of saline solution was added to the control plasma. One sample for examining was taken from the control plasma (KG and two residual were taken from experimental plasma after the addition of riboflavin either before (EG1 or post illumination (EG2. Results. Comparing the mean values of FVIII:C (% we noticed statistically significantly higher level in the EG1 group than in the EG2 group (65.00 ± 4.52 vs 63.20 ± 4.73; t = 4.323, p = 0.002, while between the KG and experimental groups (EG1 and EG2 there was no statistically significant difference in the concentration of FVIII:C. There was a statistically significant decrease of albumin concentration (g/L in the EG2 group comparing to the KG (33.35 ± 0.94 vs 31.94 ± 0.84; t = 3.534, p = 0.002, but there was no mentioned difference in albumin concentration between the KG and the EG1, so as between the EG1 and the EG2. Conclusion. Plasma inactivated by riboflavin and UV rays (Mirasol PRT sistem, Caridian BCT, USA keeps all the

  4. Milk fat globule-epidermal growth factor-factor VIII attenuates sepsis-induced acute kidney injury.

    Science.gov (United States)

    Cen, Cindy; Aziz, Monowar; Yang, Weng-Lang; Zhou, Mian; Nicastro, Jeffrey M; Coppa, Gene F; Wang, Ping

    2017-06-01

    Acute kidney injury (AKI) is most commonly caused by sepsis in critically ill patients, and it is associated with high morbidity and mortality. The pathophysiology of sepsis-induced AKI is generally accepted to include direct inflammatory injury, endothelial cell dysfunction, and apoptosis. Milk fat globule-epidermal growth factor-factor VIII (MFG-E8) is a secretory glycoprotein with a known role in the enhancement of apoptotic cell clearance and regulation of inflammation. We hypothesize that administration of recombinant mouse MFG-E8 (rmMFG-E8) can protect mice from kidney injuries caused by sepsis. Sepsis was induced in 8-wk-old male C57BL/6 mice by cecal ligation and puncture (CLP). rmMFG-E8 or phosphate-buffered saline (vehicle) was injected intravenously at a dosage of 20 μg/kg body weight at time of CLP (n = 5-8 mice per group). After 20 h, serum and renal tissue were harvested for various analyses. The renal injury markers blood urea nitrogen (BUN) and creatinine were determined by enzymatic and chemical reactions, respectively. The gene expression analysis was carried out by real-time quantitative polymerase chain reaction. At 20 h after CLP, serum levels of BUN and creatinine were both significantly increased in the vehicle group compared with the sham group, whereas the mice treated with rmMFG-E8 had a significant reduction in BUN and creatinine levels by 28% and 24.1%, respectively (BUN: 197.7 ± 23.6 versus 142.3 ± 20.7 mg/dL; creatinine: 0.83 ± 0.12 versus 0.63 ± 0.06 mg/dL; P sepsis through inhibiting the production of proinflammatory cytokines and chemokine, as well as through the activation of endothelial cells. Thus, MFG-E8 may have a therapeutic potential for treating AKI induced by sepsis. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Evolution of three cases of sarcomas of the sus-clavicular area after mammary radiotherapy; Devenir de trois cas de sarcomes de la region sus claviculaire apres radiotherapie mammaire

    Energy Technology Data Exchange (ETDEWEB)

    Renard-Oldrini, S.; Marchal, C.; Verhaeghe, J.L.; El Hajj, L.; Beckendorf, V.; Tournier-Rangeard, L.; Peiffert, D. [Centre Alexis-Vautrin, 54 - Vandoeuvre-les-Nancy (France)

    2010-10-15

    The authors comment the evolution observed for three cases of sarcomas in a previously irradiated sus-clavicular area. The three patients initially presented different cancers before the appearance of this sarcoma. The authors outline the exceptional characteristic of these sarcomas for their location in the sus-clavicular ganglionary area. Treatment is difficult. The authors suspect the existence of a genetic fragility. Short communication

  6. Computed tomography in Brazil: frequency and pattern of usage among inpatients of the Unified Health System (SUS); Tomografia computadorizada no Brasil: frequencia e padrao de uso em pacientes internados no Sistema Unico de Saude (SUS)

    Energy Technology Data Exchange (ETDEWEB)

    Dovales, Ana Cristina M.; Souza, Andressa A. de; Veiga, Lene H.S., E-mail: adovales@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2015-04-15

    This paper shows the frequency, pattern and trend of computed tomography use in inpatients of the Brazilian public health care system (SUS), from 2008 to 2011. Data were extracted from an Internet database provided by SUS. Head/neck examinations were the most frequent type of CT over the study period. The use of CT increased over time, with the greatest increase being observed for CT of extremities. (author)

  7. A prática do parto humanizado no SUS: estudo comparativo = The practice of humanized delivery in the Brazilian Health System (SUS: a comparative study

    Directory of Open Access Journals (Sweden)

    Luciele de Lima Wrobel

    2006-01-01

    Full Text Available O presente estudo descritivo foi realizado em maternidades que prestamatendimento pelo Sistema Único de Saúde (SUS, nas cidades de Guarapuava e Londrina, Estado do Paraná. Dentro do programa de Humanização implantado na Maternidade de Londrina pretendeu-se analisar o atendimento a parturiente quanto à humanização ao partocomparando com a realidade de dois hospitais de Guarapuava onde não existe o programa implantado e assim verificar se os direitos destas parturientes quanto à humanização estão sendo respeitados. Foi aplicado um questionário a 40 primíparas no puerpério imediato comperguntas semi-estruturadas. Ao comparar duas realidades diferentes, concluiu-se que alguns dos direitos das parturientes preconizados pela OMS não estavam sendo respeitados, especialmente onde não havia a implantação do parto humanizado, pois não era permitida a entrada de acompanhante e nem utilizadas técnicas de relaxamento para a parturiente, evidenciando assim que algumas instituições necessitam intensificar esses cuidados para melhorar a qualidade do atendimento prestado.This descriptive study was conducted in maternities assisted by the Brazilian Health System (SUS, in the cities of Guarapuava and Londrina, State of Paraná. In the program implanted in Londrina, the aim was to analyze the assistance to the parturient regarding humanization to the child delivery. This context was then comparedwith the reality in the maternities of two hospitals in Guarapuava, where these practices are not applied. The comparison intended to verify if the rights of these women to humanized delivery are being respected. A half-structured questionnaire was applied to forty women in labor. While comparing these two different realities, it was observed that a few of these rights, advocated by the OMS, were not being respected, especially where the humanization delivery was not a practice. Data revealed that the partner’s entrance was not allowed,neither were

  8. [Methodology for construction of a panel of indicators for monitoring and evaluation of unified health system (SUS) management].

    Science.gov (United States)

    Tamaki, Edson Mamoru; Tanaka, Oswaldo Yoshimi; Felisberto, Eronildo; Alves, Cinthia Kalyne de Almeida; Drumond Junior, Marcos; Bezerra, Luciana Caroline de Albuquerque; Calvo, Maria Cristina Marino; Miranda, Alcides Silva de

    2012-04-01

    This study sought to develop methodology for the construction of a Panel for the Monitoring and Evaluation of Management of the Unified Health System (SUS). The participative process used in addition to the systematization conducted made it possible to identify an effective strategy for building management tools in partnership with researchers, academic institutions and managers of the SUS. The final systematization of the Panel selected indicators for the management of the SUS in terms of Demand, Inputs, Processes, Outputs and Outcomes in order to provide a simple, versatile and useful tool for evaluation at any level of management and more transparent and easier communication with all stakeholders in decision-making. Taking the management of the SUS as the scope of these processes and practices in all normative aspects enabled dialog between systemic theories and those which consider the centrality of the social actor in the decision-making process.

  9. Significados y respuestas de las madres al abuso sexual de sus hijas(os

    Directory of Open Access Journals (Sweden)

    Margarita Inés Quiroz Arango

    2009-01-01

    Full Text Available Se presentan los resultados de una investigación dirigida a comprender los significados y las respuestas de madres frente al abuso sexual de sus hijas e hijos, para generar un conocimiento útil en la construcción de políticas y programas más pertinentes en la atención de este fenómeno. Es un estudio cualitativo que empleó como método los grupos de discusión con cinco madres de cuatro niñas y un niño, menores de 10 años, víctimas de abuso sexual, quienes asistían a consulta psicológica en dos centros de atención a la familia de la ciudad de Medellín, en el año 2005. Las voces de estas mujeres muestran que el abuso sexual sucede en familias vulnerables desde el punto de vista afectivo, comunicativo y socioeconómico, en las cuales este problema hace parte de su cotidianidad. El abuso sexual constituye una catástrofe que afecta el precario equilibrio socioeconómico y afectivo que estas familias logran construir para hacer frente a sus condiciones de vida angustiantes. En medio de la estigmatización que la sociedad hace de la situación, del silencio, con el cual soportan el trauma, y de un apoyo poco comprensivo y pertinente por parte de las instituciones encargadas de la atención de estas familias, las madres acometen diferentes acciones para hacer frente a su realidad. La reconfiguración de su rol como madres se convierte en un punto de partida clave para la superación del estado de impotencia en el cual quedan sumidas, posterior al abuso sexual de sus hijas(os.

  10. Propuesta de teorías integradoras para la cefalogénesis y sus malformaciones

    Directory of Open Access Journals (Sweden)

    Dadonim Vila Morales

    2013-03-01

    Full Text Available En las teorías embriogénicas de las malformaciones del macizo craneofacial es frecuente encontrar explicaciones simplistas, que no aluden a la biología celular, ni molecular de sus fisiopatologías. El propósito de esta investigación fue describir las teorías de la cefalogénesis y sus malformaciones craneofaciales, como requisito para proponerteorías integradoras que favorezcan su mejor comprensión. Se realizó una revisión biobliográfica sobre el tema de la cefalogénesis y las concepciones científicas actuales concernientes a las teorías de las malformaciones congénitas craneofaciales. Se realizó una revisión en Internet, en el periodo comprendido entre diciembre de 2011 y enero de 2012. Se analizaron los artículos de revistas de la Web of Sciences que trataron este tema desde el año 2006 hasta el 2012 en los buscadores Google academico, Hinari, Scopus, Scielo y Medline. Como resultado se obtuvieron 131 artículos que fueron tamizados; pero el estudio se ciñó solo a 43 artículos que enfocaron estas temáticas de manera más integral. Se consideraron reduccionitas o incompletas las teorías hasta ahora expuestas. Por tal motivo se propusieron teorías holístico-sinérgicas de la cefalogénesis y sus malformaciones.

  11. Reflections on the Production of the Formation of Physiotherapy in the Con-text of SUS

    Directory of Open Access Journals (Sweden)

    Ana Luísa Pinho Pinto Ferreira

    Full Text Available Abstract Background: This study was motivated by the need of understanding how the relationship of the training with the national health system is treated, both in the sphere of health services and the aca-demic area. This work aims to contribute to the debate on the inclusion of the physiotherapist in SUS (Brazil's NHS by pointing out issues that need to be deepened in future studies. Purpose: To analyze the national literature production on the relationship between the training of therapists and their work in SUS, from 1996 to 2010. Methods: Descriptive research with literature on the bases: LILACS, SCI-ELO Bank and CAPES thesis. Results: We found 13 publications, sorted by: year, publication type, region where it was published in the categories "national curriculum guidelines," "professional respon-sibility", "integrality in health" and "conceptions of teachers in training in Physiotherapy ". There no publishing from 1996 to 2005, gradually increasing from this year. It was identified a higher number of articles compared to other types of publications; there is also an important difference between the Brazilian regions, with higher prevalence of studies in the South (53.8% and a greater number of pub-lications in the category "national curriculum guidelines". Conclusion: It was possible to raise ques-tions that involve the applicability of the National Curriculum Guidelines on the pedagogical courses; suitability of teachers to the reality of SUS; investigation of the models covered in health care envi-ronments trainers, and the lack of contribution by higher education institutions on teaching-research and teaching and public service, contributing to form an important agenda of study. {#}

  12. SUS Brasil: a região de saúde como caminho

    Directory of Open Access Journals (Sweden)

    Lenir Santos

    2015-06-01

    Full Text Available O presente artigo desenvolve o tema da necessidade de se regionalizar a descentralização no sentido de aglutinar o que esta supostamente poderia ter fracionado. Ao revisitar a diretriz constitucional da descentralização os autores propõem medidas que visem sua garantia ao lado de ferramentas administrativas que permitam a formação de regiões de saúde resolutivas em pelo menos 95% das necessidades de saúde do território regional, para garantir autonomia sanitária. Os autores propõem soluções que passam pela criação de pessoas jurídicas associativas regionais, resultantes da aglutinação dos entes federativos em região de saúde. Apontam ainda o que não deu certo no Sistema Único de Saúde - SUS Brasil em razão tanto de equívocos originados nas melhores intenções, quanto do oportunismo que esses equívocos geraram. Advogam os autores a necessidade de respostas jurídico-administrativas para um SUS de caráter interfederativo tanto na sua gestão, que exige compartilhamentos, quanto no seu financiamento, que se mantém interdependente também. Concluem que o único caminho para o SUS ser nacional, é regionalizá-lo e dotar a região de saúde de todo o instrumental necessário à gestão compartilhada, interfederativa e responsável.

  13. Adolescentes consumidores de televisión: autopercepciones sobre sus derechos

    Directory of Open Access Journals (Sweden)

    María Ángeles Espinosa Bayal

    2014-07-01

    Full Text Available El artículo analiza la percepción que tiene una muestra representativa de la población española de entre 12 y 18 años sobre la protección de sus derechos en las cadenas de televisión. Para conseguir este objetivo, se aplicó un cuestionario de 59 preguntas diseñado para una investigación más amplia en la que se analizaba la opinión de los menores sobre la protección de sus derechos en la televisión y en Internet. Ninguna pregunta del cuestionario se refería a cadenas o programas concretos identificados por los investigadores y la información sobre estos partía de la propia opinión de los adolescentes. Los resultados que se presentan se refieren a los datos sobre televisión y, más concretamente, al respeto por los derechos fundamentales de los telespectadores en general, y de los de los menores en particular. De estos resultados se concluye que los adolescentes perciben claramente la vulneración de los derechos de igualdad, dignidad e intimidad, a la información objetiva veraz y plural y a la libre expresión y opinión –especialmente cuando ésta se refiere a los niños–. Igualmente muestran una postura crítica y de rechazo hacia los tipos de programas que no respetan sus derechos. Se propone utilizar esta capacidad crítica de los telespectadores desde una doble perspectiva: por una parte para crear escuela de ciudadanía y, por otra, para generar una sociedad más justa y equitativa.

  14. Anticuerpo anti-Dectin-1 humano, hibridoma productor de dicho anticuerpo y sus aplicaciones

    OpenAIRE

    Llorente Gómez, María de las Mercedes; Fernández Ruíz, Elena; Galán Díez, Marta; Kremer, Leonor; Casasnovas, José María

    2008-01-01

    Anticuerpo anti-Dectin-1 humano, hibridoma productor de dicho anticuerpo y sus aplicaciones. La presente invención consiste en el hibridoma MGD3 y el anticuerpo monocional producido por él (denominado también MGD3), que reconoce de forma especifica al receptor de membrana Decti-1 humano. El anticuerpo MGD3 es capaz de inhibir la unión de Dectin-1 a su ligando natural, los -glucanos que son componentes de la pared de los hongos. Además, bloquea específicamente la un...

  15. El estado y sus márgenes: Etnografías comparadas

    OpenAIRE

    Das, Veena; Poole, Deborah

    2008-01-01

    La Teoría Política occidental ha concebido el estado como forma administrativa racional de organización y orden político. Uno de los efectos resultantes de pensar el estado en términos de sus funciones de producción de orden es que los márgenes espaciales y sociales, que tan a menudo constituyen el terreno del trabajo de campo etnográfico, son contemplados como lugares de desorden en los que el estado ha sido incapaz de imponer su orden. No obstante es posible invertir el interrogante y pregu...

  16. Importancia de los padres y madres en la competición deportiva de sus hijos

    OpenAIRE

    Campos Mesa, María del Carmen; Castañeda Vázquez, Carolina; Garrido Guzmán, María Encarnación

    2010-01-01

    Cuando se habla del término deporte, hay que tener en cuenta los agentes sociales que influyen en toda práctica de actividad física, ya sean técnicos deportivos, compañeros o padres/madres. Más aún, si hablamos del deporte en los niños, estos agentes sociales cobran una especial relevancia en su actividad deportiva. En este sentido, el presente artículo muestra la actuación y el comportamiento que tienen los padres y madres en la competición deportiva de sus hijos. El conocer q...

  17. LA INSEGURIDAD LABORAL Y SUS CONSECUENCIAS EN UN CONTEXTO DE CRISIS ECONÓMICA

    Directory of Open Access Journals (Sweden)

    Beatriz Sora

    2014-01-01

    Full Text Available La inseguridad laboral se ha convertido en la actualidad en una de las fuentes de estrés más significativas para muchos trabajadores, siendo especialmente grave en España por las elevadas tasas de desempleo en este periodo de crisis económica. Una prolífera investigación se ha desarrollado al respecto en un intento por alcanzar un conocimiento más completo de este fenómeno. El Instituto de Psicología de los Recursos Humanos, Desarrollo Organizacional y Calidad de Vida Laboral (IDOCAL ha contribuido a esta investigación en los últimos años en varias de sus facetas más significativas. En el ámbito de sus factores determinantes se ha identificado un papel significativo de la antigüedad laboral, la empleabilidad en el mercado laboral, el subempleo, y la autoeficacia laboral. Además se han realizado hallazgos de interés en relación con la diversidad de los tipos de contrato, la inseguridad laboral y sus efectos en los trabajadores. Son de especial interés los estudios que analizan el papel interviniente de distintas variables. En este contexto, nuestros estudios han puesto de manifiesto la relevancia de variables como la justicia organizacional, el clima de justicia organizacional, el apoyo organizacional, la empleabilidad, la dependencia laboral y el distanciamiento psicológico a la hora de predecir la variabilidad en la inseguridad laboral. Por último, las aportaciones del IDOCAL han sido especialmente relevantes al plantear el análisis de la inseguridad laboral como fenómeno colectivo y mostrar cómo la experiencia colectiva de la inseguridad tenía repercusiones sobre el bienestar de los trabajadores más allá de las producidas por sus percepciones individuales. En base a esta investigación se han propuesto en el presente artículo una serie de implicaciones para la práctica profesional.

  18. El papel de los padres en la salud sexual de sus hijos

    OpenAIRE

    Bárcena Gaona,Susana; Robles Montijo,Susana; Díaz-Loving,Rolando

    2013-01-01

    Los propósitos de este estudio fueron identificar las variables que predicen la intención de usar condón en adolescentes sin experiencia sexual, y conocer el papel que desempeñan los padres en dichas variables. Se obtuvo información de 290 estudiantes y sus padres (n=290) mediante un instrumento de autoinforme. Los resultados mostraron que los jóvenes tienen mayor intención de usar condón en la medida que se perciben capaces de usarlo (autoeficacia). Los padres tuvieron una influencia en vari...

  19. Jóvenes escolares y sus redes sociales: de la territorialidad a la virtualidad.

    OpenAIRE

    Soler Osuna, Diana Maritza

    2013-01-01

    El problema de investigación de la investigación, Jóvenes escolares y sus redes sociales: de la territorialidad a la virtualidad, surgió a partir de mi experiencia como profesora de geografía en un colegio privado de Bogotá. Me cuestionaba la restringida territorialidad de los estudiantes y suponía que entre menos conocieran el territorio de la ciudad, menor sería su interés por la problemática en el espacio local. Bajo este supuesto emprendí el reconocimiento de las Redes Sociales y las Terr...

  20. Explorando la agencia de las mujeres encarceladas a través de sus experiencias amorosas

    OpenAIRE

    de Miguel Calvo, Estibaliz

    2017-01-01

    El presente trabajo explora la agencia de las mujeres encarceladas a través de sus experiencias emocionales, una agencia caracterizada por la redefinición de la propia identidad y por las decisiones en la vida emocional, que resultan disruptivas de las lógicas carcelarias. La base de este análisis es la investigación cualitativa con entrevistas semiestructuradas y observación participante desarrolladas en el departamento de mujeres de la cárcel de Nanclares de Oca (Álava). El amor de pareja c...

  1. La cuarta ventana: Transformando el hogar. Arte feminista y sus intervenciones en el ciberespacio

    Directory of Open Access Journals (Sweden)

    Fabiane Santos

    2012-04-01

    Full Text Available Ese texto trata de la transformación del hogar como espacio público, habitado y activo, desde la perspectiva de la mujer que transita y construye este espacio, el cual está siendo invadido por los medios tecnológicos y la comunicación de masas. A través de las prácticas artísticas y cuestiones relativas al movimiento ciberfeminista y sus acciones, observaremos como esas luchas hacen eco y se mezclan con los nuevos medios.

  2. La productividad española: características y sus causas (1995-2013)

    OpenAIRE

    Jalón Aymerich, Francisco de Borja

    2015-01-01

    El objetivo del presente ensayo es comprender algunos de los determinantes que afectan el comportamiento de la productividad laboral española además de describir sus características. Se discuten algunas de las explicaciones ofrecidas por la literatura económica y se analizan algunas posibilidades, encontrando que el tamaño empresarial y la distribución de valor añadido entre grupos de tamaño es uno de los determinantes principales de la productividad.

  3. La reticencia a hablar en las aulas de ELE en Corea. Un acercamiento a sus causas

    Directory of Open Access Journals (Sweden)

    Mendoza Puertas, Jorge Daniel

    2016-03-01

    Full Text Available La baja participación de los estudiantes de Asia oriental en las clases de lenguas extranjeras ha sido constatada por diversos investigadores. En este trabajo ofrecemos un estudio de carácter cualitativo basado en entrevistas, grupos de discusión y anotaciones realizadas en un diario de trabajo. A través de sus resultados pretendemos ofrecer luz acerca de las causas sobre las que descansa la reticencia a hablar de los estudiantes coreanos en las aulas universitarias de español como lengua extranjera.

  4. Contribuciones Tomistas. Al estudio de las emociones y algunos de sus corolarios éticos

    Directory of Open Access Journals (Sweden)

    Lamartine de Hollanda Cavalcanti Neto

    2011-01-01

    Full Text Available El presente estudio ofrece, desde una perspectiva teórica, una breve visión de conjunto de la concepción tomista sobre las emociones, su encaje en el ciclo de la vida consciente, su génesis, su clasificación, su encadenamiento y su dinamismo. Desarrolla consideraciones sobre las contribuciones que este referencial teórico puede aportar al estudio de las emociones y deduce algunos de sus principales corolarios éticos.

  5. OPTIMIZACION DE LA MORFOLOGIA DE ELECTRO-DEPOSITOS DE POLITIOFENO, CON VISTA A SUS POSIBLES APLICACIONES

    OpenAIRE

    GACITUA SANTALICES, MANUEL ALEJANDRO; GACITUA SANTALICES, MANUEL ALEJANDRO

    2012-01-01

    El impactante número de investigaciones relacionadas con los polímeros conductores, seguramente se explica por las mismas razones que justificaron el Premio Nobel a sus descubridores el primer año de este milenio: su enorme impacto social, por su gran diversidad de aplicaciones, algunas de las cuales ya se concretan, mientras otras son todavía incipientes, o sólo se vislumbran por parte de algunos visionarios. En todo caso, los principales desafíos actuales en el área los co...

  6. Abstracción en la pintura occidental. Sus elementos y su efecto en el espectador

    OpenAIRE

    TRICIO ECHARRI, PALOMA

    2015-01-01

    La evolución de la pintura y sus técnicas a lo largo de la historia y más concretamente en la pintura abstracta, que junto a los efectos en la percepción y los referentes obtenidos ayudan a conformar una serie de cuadros de carácter formalista y minimalista. The evolution of painting and its techniques throughout history and more specifically in abstract painting, which together with the effects on perception and the obtained precedents help out to create a series of formalist and minimali...

  7. Anatomía del raquis, sus curvas y su control ortostático

    OpenAIRE

    Aurnague, Jaqueline; Fernández, Hernán

    2013-01-01

    Nos decidimos a realizar la siguiente ponencia, para analizar y reconocer aquellos aspectos anatómicos y funcionales de la columna vertebral o raquis en relación a sus curvas fisiológicas y a su control ortostatico. El abordaje que efectuaremos, es teniendo en cuenta los contenidos que constantemente estabilizan y desestabilizan el raquis en los movimientos de la vida cotidiana, como también aquellos enfocados en la actividad física en relación a la postura y a su tonicidad. Analizaremos l...

  8. La psicología del deporte y sus relaciones con otras ciencias del deporte

    OpenAIRE

    Garcia Mas, Alexandre

    1997-01-01

    La evolución de la Psicología del Deporte hasta la actualidad ha conllevado la existencia de modificaciones dinámicas en las esferas de relaciones con las distintas áreas de la psicología —por un lado— y de relaciones con las demás Ciencias del Deporte, por otro. Así, podemos hablar de la existencia de dos distintas galaxias de relaciones, centrada una en la Psicología del Deporte y la otra en el propio hecho deportivo, que ofrecen panoramas interactivos distintos. Esta evolución —y sus fases...

  9. Radón y sus efectos en la salud en trabajadores de minas de uranio

    OpenAIRE

    Gonzalo Aicardi-Carrillo; Marita Asmat-Inostrosa; Yanelly Barboza-Rangel

    2015-01-01

    Introducción: El radón es un gas presente en subsuelo, especialmente en minas de uranio, que produce consecuencias sobre la salud, entre las que destaca el cáncer de pulmón. En EEUU es la segunda causa de mortalidad por esta enfermedad. Pese a la fuerte relación causal no existe normativa específica europea de regulación en mineros. Objetivos: Identificar el efecto del radón y sus derivados sobre la salud de los trabajadores de minas de uranio; describir la asociación entre exposición a radón...

  10. La historia del Derecho Internacional Privado en China y sus fuentes

    OpenAIRE

    Laura Soto von Arnim

    2014-01-01

    El Derecho Internacional chino tiene una historia larga, pues su primera disposición data del Código Mingli de la Dinastía Ming. A pesar de sus tempranos comienzos, el Derecho Internacional Privado comenzó a desarrollarse verdaderamente desde la década de los años 1980. Esta rama del derecho está constituida en China por las normas de conflictos de leyes, las normas de conflictos de jurisdicción, y el reconocimiento y la ejecución de resoluciones judiciales en materia civil y mercantil. A...

  11. PROCESADORA Y COMERCIALIZADORA DE PASTA DE CACAO Y SUS DERIVADOS EN ECUADOR

    OpenAIRE

    Pabón-Andrade, Johana Gabriela

    2016-01-01

    El presente trabajo de fin de master tiene como objetivo realizar un plan de negocios de una empresa dedicada al procesamiento y comercialización de pasta de cacao y sus derivados en Ecuador. Las actividades de la empresa consistirán en comprar cacao, sin ningún procesamiento y transformarlo en pasta de cacao. A lo largo de este proceso se producen derivados como manteca de cacao, pulpa de cacao, cascara, ceniza de cacao, que junto con las pasta serán comercializados tanto dentro como fuer...

  12. Los concheros de Baja California y sus perspectivas de investigación

    OpenAIRE

    Agustín Téllez Duarte

    1987-01-01

    El presente artículo pretende enfatizar sobre la presencia de conchas en sitios arqueológicos, los cuales nos proporcionan una gran cantidad de información cultural sobre los asentamientos humanos, particularmente en los concheros de Baja California. En Baja California se localizan en forma intermitente a todo lo largo de sus costas, tanto en el golfo de California como en el Pacífico. Con este proyecto se pretende rescatar aquellas colecciones que aún puedan conservarse, considerando que las...

  13. La mortalidad infantil y sus causas en la inclusa de Toledo entre 1900-1910

    OpenAIRE

    Martín Espinosa, Noelia M.; Cobo Cuenca, Ana I.

    2013-01-01

    La asistencia sanitaria se vinculaba a acciones benéficas hacia los pobres. Hasta el siglo XX fue frecuente el abandono de niños en inclusas, donde las cifras de mortalidad eran catastróficas. El objetivo de esta investigación es estudiar la mortalidad infantil y sus causas en los niños abandonados en la inclusa de Toledo entre 1900 y 1910. Es un trabajo histórico que analiza las fuentes primarias (libros de lactancias y destetes, con datos sobre el momento de la muerte y su causa) a partir d...

  14. Caracterización de ancianos frágiles y sus cuidadores

    OpenAIRE

    Marina Selin Ganén; Marlén del Valle Pérez

    2012-01-01

    Fundamento: la atención geriátrica está dirigida a evitar la limitación y la dependencia de las personas mayores, mejorar su calidad de vida y la capacidad funcional de atenderse a sí mismos y desarrollarse en el seno de una familia y de la sociedad. Objetivo: caracterizar a los ancianos frágiles y sus cuidadores. Métodos: estudio descriptivo realizado en el Área 6 de Cienfuegos que incluyó 75 ancianos, evaluados como frágiles según la escala de evaluación funcional, y a 62 cuidadores. En los...

  15. ¿Sigue la Agencia Europea del Medicamento sus propias reglas? Cuento con moraleja

    OpenAIRE

    Ruiz Cantero, María Teresa; Moreno Mújica, A.; Chilet Rosell, Elisa; Laguna Goya, Noa

    2014-01-01

    Antecedentes/Objetivos: Los sesgos de género en los ensayos clínicos (EC) se demostraron ya en los 90. Objetivo: analizar el cumplimiento del Informe Público Europeo de Evaluación (EPAR) de anticonceptivos y fármacos para la disfunción eréctil (FDE) realizado por la Agencia Europea de Medicamentos (EMA) respecto a sus recomendaciones de elaboración. Métodos: Análisis del contenido sobre eficacia, seguridad, farmacocinética (FC) y farmacodinámica (FD) del EPAR de 3 anticonceptivos y 3 FDE, y d...

  16. SOFTWARE LIBRE, SUS HERRAMIENTAS PARA LA INFORMATIZACIÓN DE LA SOCIEDAD

    OpenAIRE

    Shouddy Tárano León

    2006-01-01

    La informatización en Cuba comprende el uso de la computación en todos los sectores de la sociedad. Los usuarios en sus máquinas poseen una serie de aplicaciones informáticas que facilitan la navegación por Internet, la elaboración de documentos, presentaciones, hojas de cálculo electrónicas, así como otras aplicaciones dedicadas a reproducir música, vídeo, y demás utilidades. Los desarrolladores del software y diseñadores gráficos, basan su trabajo en programas que permiten un mejor empleo d...

  17. Los mochileros y sus relatos : Desde una mirada etnográfica

    OpenAIRE

    Belloli Orrijola, Luciana

    2014-01-01

    La presente tesis propone indagar como se reconfigura los relatos de Mochileros como viajero y generador de relatos/escritos gracias a sus vivencias durante el viaje, desde una mirada etnográfica. Se desarrolla partiendo del marco teórico explicativo, con conceptos a describir e interpretar como el viaje, el viajero y el turista, los mochileros, y los relatos. Se aplica una metodología cualitativa, utilizando como técnica la etnografía, recurriendo a insumos como el relato de viajes tanto per...

  18. Nuevos aminoácidos cuaternarios derivados de azepanos y sus aplicaciones

    OpenAIRE

    Núñez Villanueva, Diego; Bonache de Marcos, María Ángeles; Martín Martínez, María Mercedes; García-López, M. Teresa; González Muñiz, María Rosario

    2008-01-01

    Nuevos aminoácidos cuaternarios derivados de azepanos y sus aplicaciones. Compuestos (aminoácidos alfa, alfa-heterocíclicos) en los que el heterociclo posee estructura de azepano, oxoazepano o tioazepano, capaces de inducir estructura secundaria en péptidos o de servir como esqueletos de utilidad en la preparación de quimiotecas de compuestos de interés terapéutico. Además, la invención se refiere al procedimiento de obtención de dichos compuestos.

  19. Driven equilibrium (drive) MR imaging of the cranial nerves V-VIII: comparison with the T2-weighted 3D TSE sequence.

    Science.gov (United States)

    Ciftci, E; Anik, Yonca; Arslan, Arzu; Akansel, Gur; Sarisoy, Tahsin; Demirci, Ali

    2004-09-01

    The aim of this study is to evaluate the efficacy of the driven equilibrium radio frequency reset pulse (DRIVE) on image quality and nerve detection when used in adjunction with T2-weighted 3D turbo spin-echo (TSE) sequence. Forty-five patients with cranial nerve symptoms referable to the cerebellopontine angle (CPA) were examined using a T2-weighted 3D TSE pulse sequence with and without DRIVE. MR imaging was performed on a 1.5-T MRI scanner. In addition to the axial resource images, reformatted oblique sagittal, oblique coronal and maximum intensity projection (MIP) images of the inner ear were evaluated. The nerve identification and image quality were graded for the cranial nerves V-VIII as well as inner ear structures. These structures were chosen because fluid-solid interfaces existed due to the CSF around (the cranial nerves V-VIII) or the endolymph within (the inner ear structures). Statistical analysis was performed using the Wilcoxon test. P DRIVE pulse shortens the scan time by 25%. T2-weighted 3D TSE sequence with DRIVE performed slightly better than the T2-weighted 3D TSE sequence without DRIVE in identifying the individual nerves. The image quality was also slightly better with DRIVE. The addition of the DRIVE pulse to the T2-weighted 3D TSE sequence is preferable when imaging the cranial nerves surrounded by the CSF, or fluid-filled structures because of shorter scan time and better image quality due to reduced flow artifacts.

  20. MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MELALUI PEMBELAJARAN KOOPERATIF THINK-TALK-WRITE PADA PESERTA DIDIK KELAS VIII1 MTsN MODEL MAKASSAR

    Directory of Open Access Journals (Sweden)

    Andi Dian Angriani

    2016-06-01

    Full Text Available Penelitian ini bertujuan untuk: (1 Mendeskripsikan penerapan pembelajaran kooperatif Think-Talk-Write (TTW yang dapat meningkatkan kemampuan pemecahan masalah matematika pada peserta didik kelas VIII1 MTsN Model Makassar, (2 Mendeskripsikan peningkatan kemampuan pemecahan masalah matematika melalui penerapan pembelajaran kooperatif Think-Talk-Write pada peserta didik kelas VIII1 MTsN Model Makassar. Penelitian ini dilaksanakan dalam dua siklus, masing-masing siklus terdiri dari 4 tahap, yaitu tahap perencanaan (planning, pelaksanaan tindakan (acting, observasi (observing/evaluasi (evaluating dan refleksi (reflecting. Hasil penelitian menunjukkan bahwa: (1 Pembelajaran kooperatif Think-Talk-Write dapat meningkatkan kemampuan pemecahan masalah matematika, meliputi: (a Pada tahap berpikir (think, peserta didik membaca dan mamahami LKPD yang dibagikan secara individu dan diberi kesempatan untuk bertanya jika ada hal yang kurang dipahami. (b Pada tahap berdiskusi (talk, peserta didik terdiri dari 4 orang, berdiskusi secara berpasangan kemudian dipertukarkan dengan pasangan lain dalam kelompoknya, dan diberikan kesempatan untuk bertanya. (c Pada tahap menulis (write, setelah berdiskusi menyatukan pendapat, peserta didik menuliskan hasil diskusinya secara individual, (2 Peningkatan kemampuan pemecahan masalah tersebut sebagai berikut: pada siklus I, rata-rata hasil belajar peserta didik 72,85 meningkat menjadi 89,63 pada siklus II. Pada siklus I, terdapat 18 siawa (45% yang telah mencapai nilai KKM namun ketuntasan belajar secara klasikal belum tercapai. Sedangkan dari hasil tes siklus II, terdapat 33 peserta didik (82,5% yang telah mencapai nilai KKM dan ketuntasan belajar secara klasikal sudah tercapai.

  1. French previously untreated patients with severe hemophilia A after exposure to recombinant factor VIII : incidence of inhibitor and evaluation of immune tolerance.

    Science.gov (United States)

    Rothschild, C; Laurian, Y; Satre, E P; Borel Derlon, A; Chambost, H; Moreau, P; Goudemand, J; Parquet, A; Peynet, J; Vicariot, M; Beurrier, P; Claeyssens, S; Durin, A; Faradji, A; Fressinaud, E; Gaillard, S; Guérin, V; Guérois, C; Pernod, G; Pouzol, P; Schved, J F; Gazengel, C

    1998-11-01

    Fifty French previously untreated patients with severe hemophilia A (factor VIII brand of recombinant factor VIII (rFVIII), were evaluated for inhibitor development, assessment of risk factors and outcome of immune tolerance regimen. The median period on study was 32 months (range 9-74) since the first injection of rFVIII. Fourteen patients (28%) developed an inhibitor, four of whom (8%) with a high titer (> or = 10 BU). All inhibitor patients but one continued to receive rFVIII either for on-demand treatment or for immune tolerance regimen (ITR). Among these patients, inhibitor was transient in 2 (4%), became undetectable in 6 and was still present in 6. The prevalence of inhibitor was 12%. Presence of intron 22 inversion was found to be a risk factor for inhibitor development. Immune tolerance was difficult to achieve in our series despite a follow-up period of 16 to 30 months: immune tolerance was complete in only one out of the 3 patients undergoing low dose ITR and in one out of the 5 patients with high dose ITR.

  2. Pig-mentation: postmortem iris color change in the eyes of Sus scrofa.

    Science.gov (United States)

    Abraham, Elizabeth; Cox, Margaret; Quincey, David

    2008-05-01

    Experienced forensic pathologists and examiners may be familiar with the phenomenon of postmortem iris color change; however, only Knight, Simpson's forensic medicine, Arnold, London, 1997; Ref. 1 and Saukko and Knight, Knight's forensic pathology, 3rd ed., Arnold, London, 2004; Ref. 2 have referred to it in the literature, and to date, there have been no published scientific research studies on this taphonomic artifact. A controlled experiment was conducted of postmortem changes to isolated Sus scrofa eyes. The eyes (n = 137) were separated into three groups and each sample was observed for 3-day postmortem at a different temperature. In addition, a Sus scrofa head was obtained to observe postmortem changes of eyes in situ. All isolated blue eyes in the experiment, at room temperature and higher, changed to brown/black within 48 h. The in situ blue eye, at room temperature, turned brown/black within 72 h. If iris color consistently changes postmortem in humans, then this taphonomic artifact must be incorporated into victim identification protocol, including disaster victim identification software, and autopsy reports to prevent inaccurate victim identification and inappropriate exclusion from the identification process.

  3. La historia del Derecho Internacional Privado en China y sus fuentes

    Directory of Open Access Journals (Sweden)

    Laura Soto von Arnim

    2014-01-01

    Full Text Available El Derecho Internacional chino tiene una historia larga, pues su primera disposición data del Código Mingli de la Dinastía Ming. A pesar de sus tempranos comienzos, el Derecho Internacional Privado comenzó a desarrollarse verdaderamente desde la década de los años 1980. Esta rama del derecho está constituida en China por las normas de conflictos de leyes, las normas de conflictos de jurisdicción, y el reconocimiento y la ejecución de resoluciones judiciales en materia civil y mercantil. A pesar de las diferentes opiniones sobre el mejor tipo de codificación entre una codificación completa o de cada materia, la más reciente ley china de derecho internacional, del 28 de octubre de 2010, codificó únicamente las normas de conflictos de leyes. Esta ley representa un progreso importante en el desarrollo del Derecho Internacional Privado en China a pesar de que algunas de sus disposiciones hayan sido muy criticadas.

  4. Ver-Sus: relato de vivências na formação de Psicologia

    Directory of Open Access Journals (Sweden)

    Flavio Martins de Souza Mendes

    Full Text Available Este artigo discute a formação em Psicologia a partir de uma experiência de estágio interdisciplinar de vivência, o projeto VER-SUS (Vivência e Estágio na Realidade do Sistema Único de Saúde, realizado por estudantes da área da saúde junto ao movimento estudantil desses cursos. A partir dessa experiência, ocorrida em 2008, no estado do Espírito Santo (VER-SUS/ES 2008, problematizamos a formação do psicólogo, afirmando a importância de ampliar a associação entre o ensino tradicional e ações que remetam às vivências interdisciplinares. Estas mesmas se configuram como estratégias de ensino-aprendizagem fundamentais para a Psicologia e para a área da saúde como um todo. Por fim, ressaltamos a importância da constante revisão das práticas, da formação e do papel do psicólogo, para pensarmos sobre outras formas de aprendizagem e diálogo ao longo do ensino superior.

  5. Agricultura sustentable y sus posibilidades en relación con consumidores urbanos

    Directory of Open Access Journals (Sweden)

    Raquel Salgado Sánchez

    2015-01-01

    Full Text Available El mercado provee incentivos a los agricultores y asociado al consumo urbano influye en el tipo de tecnología que se aplica en la agricultura. Si los consumidores tomaran decisiones de abasto en interacción con los agricultores y sus decisiones de producción, sería posible favorecer la reproducción de sistemas de agricultura sustentable. En este artículo se presentan y analizan comentarios de habitantes de la ciudad de México, conseguidos en sesiones de grupos de enfoque, de sus opiniones sobre agricultura, agricultores y prácticas de abasto. Se identificaron tendencias de desconocimiento y desconexión entre consumidores urbanos de clase media y agricultura. Si los consumidores comprendieran que su interacción con los agricultores puede contribuir a la sustentabilidad de la agricultura, en esta se podría integrar la diversidad biológica y social.

  6. Experiencias de reconocimiento vividas por los niños en sus familias

    Directory of Open Access Journals (Sweden)

    Magda Victoria Díaz Alzate

    2015-07-01

    Full Text Available Pretendemos establecer una relación entre la propuesta que hace Axel Honneth sobre el reconocimiento en el amor y las prácticas de crianza vividas por los integrantes de la familia, en especial entre los niños y las personas cuidadoras, para argumentar que en estas relaciones se da comienzo a la configuración de los niños como sujetos políticos. Para Honneth –quien retoma a Hegel y a Mead–, las primeras relaciones amorosas son sustanciales para vivir el reconocimiento afectivo –que se vive con los más íntimos–; en ellas la aceptación emocional va unida a sentimientos como la simpatía y la atracción, y les permite visibilizar al otro a partir de sus necesidades propias y su valor humano. Abordaremos la familia como primera estructura de acogida y primer escenario de socialización, para argumentar que los niños viven en sus familias, prácticas de reconocimiento de sí mismos, de los otros y del mundo que les rodea, lo cual, a nuestro modo de ver, hace parte de su proceso de socialización como sujetos políticos.

  7. Formação para o SUS nos cursos de psicologia em Alagoas

    Directory of Open Access Journals (Sweden)

    Simone Maria Hüning

    2013-03-01

    Full Text Available Este artigo discute a formação do psicólogo em Alagoas e sua relação com o Sistema Único de Saúde (SUS, a partir da análise dos currículos dos quatro cursos de graduação em Psicologia do Estado. Construímos quatro eixos de análise das disciplinas a partir das ementas, conteúdos programáticos e bibliografias: 1 Clínica, psicopatologia e avaliação psicológica; 2 Biomédicas; 3 Interfaces socioculturais; 4 Fundamentos da pesquisa e atuação em Psicologia. Discutimos as formas de abordagem da saúde, problematizando sua relação com o princípio da integralidade do SUS. Os resultados indicam que na abordagem da saúde predominam conteúdos referentes à identificação e classificação de transtornos e psicopatologias, e uma concepção de sujeito individualista e fragmentada, baseada no modelo biomédico. Por sua vez, a abordagem da integralidade, quando presente nos currículos, possui o potencial de nortear mudanças na graduação, vinculando-se a cenários diversificados, como atuação multiprofissional e capacitação profissional generalista.

  8. [SUS management and monitoring and evaluation practices: possibilities and challenges for building a strategic agenda].

    Science.gov (United States)

    Carvalho, André Luis Bonifácio de; Souza, Maria de Fátima; Shimizu, Helena Eri; Senra, Isabel Maria Vilas Boas; Oliveira, Kátia Cristina de

    2012-04-01

    This paper deals with the challenges involved in institutionalizing Monitoring and Evaluation practices within the scope of management of the Brazilian Unified Health System (SUS), based on the creation of a strategic agenda. This is structured around actions by the Federal Administration, from the perspective of defining the scope of the federative relationship. A summarized literature review is thus presented, placing into context the current SUS management process, which is based on the Pact for Health as well as theoretical and operational aspects inherent to monitoring and evaluation practices. The approach related to the strategic agenda highlights the creation of mechanisms that underpin the political and institutional decision, namely the creation of financial incentives and the development of technical mechanisms. These include organizational strategies for qualifying management teams and conducting studies and research and the dissemination of strategic information. These processes are based on the concept of providing for the management specificities in the different spheres of management based on a broad cooperation process involving teaching and research institutions and international organizations as well as the managers themselves.

  9. Las relaciones especiales de sujeción entre el Estado y sus funcionarios

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Ardila Quiroz

    2012-01-01

    Full Text Available Este escrito hace alusión a relaciones que existe entre el Estado y sus funcionarios, desde la obediencia en Grecia, hasta la connotación que adquiere el servidor público en el Estado Social de Derecho; y a su vez, las de estos para con sus asociados, pues bien sabido es que quienes sostienen al Estado y a todo el personal necesario para la exteriorización de aquel, son quienes pagan impuestos y contribuyen para que el presupuesto de gastos en bienes y servicios lleguen a buen puerto.Así como existen obligaciones por parte del Estado, también existen deberes que cumplir por parte de quienes lo habitan, por eso es de obligatorio cumplimiento, so pena de incurrir en un delito, el pago de contribuciones a favor del Estado, pero para que las erogaciones por parte del Estado hacia su población tengan la teleología o el fin propuesto, es necesario de una buena administración, si ello no acontece, se pierde la filosofía de las buenas maneras.

  10. Insulinas Análogas: responsabilidade do SUS e a judicialização

    Directory of Open Access Journals (Sweden)

    Jorge Lima

    2015-12-01

    Full Text Available Trata-se de um estudo descritivo, epidemiológico e analítico com abordagem qualiquantitativa. O artigo buscou identificar a relação entre cobertura da Estratégia de Saúde da Família e o aumento de ações judiciais de insulinas análogas nas regiões Sul e Nordeste do Brasil. Nos anos 2010, 2011 e 2012, o consumo de insulinas análogas foi crescente tanto na região sul quanto nordeste. A região sul, apesar de ter um SUS organizado, IDH desenvolvido e educação estruturada, apresentou falhas no programa de diabetes. Em contrapartida, a região nordeste possui IDH baixo na maioria dos municípios e educação deficiente, porém, observou-se a necessidade de reorganização dos programas voltados ao atendimento de usuários portadores de doenças crônicas, em especial, a diabetes, nessa região. Entende-se, que o fortalecimento da atenção básica como porta de entrada para o SUS, nas regiões estudadas pode minimizar o problema da judicialização da saúde.

  11. Moessbauer spectroscopy of He irradiated austenitic stainless steel SUS304 at low temperature

    Energy Technology Data Exchange (ETDEWEB)

    Horii, Kiyomasa; Ishibashi, Tetsu; Toriyama, Tamotsu; Wakabayashi, Hidehiko; Iijima, Hiroshi [Musashi Inst. of Tech., Tokyo (Japan); Kawasaki, Katsunori; Hayashi, Nobuyuki; Sakamoto, Isao

    1996-04-01

    SUS 304 austenitic stainless steel causes the magnetic transition at 60 K, and the Young`s modulus lowers. In addition, its composition elements have the large (n,{alpha}) reaction cross section to high energy neutrons, and helium is apt to be generated, and this is a factor that lowers the material strength. In the He-irradiated parts in austenitic stainless steel, the precursory state of martensite transformation should exist, and its effect is considered to be observable by carrying out low temperature Moessbauer spectroscopy. As to the preparation of He-irradiation samples, the SUS 304 foils used and the irradiation conditions are described. The measurement of low temperature Moessbauer spectra for the samples without irradiation and with irradiation is reported. In order to determine the magnetic transition point, the thermal scanning measurement was carried out for the samples without or with irradiation. The martensite transformation was measured by X-ray diffraction and transmission type Moessbauer spectroscopy. In order to observe the state of the sample surfaces, the measurement by internal conversion electron Moessbauer spectroscopy was performed. These results and the temperature dependence of the Moessbauer spectra for the irradiated parts are reported. (K.I.)

  12. El etnólogo y sus fantasmas. Leiris en África

    Directory of Open Access Journals (Sweden)

    Giobellina Brumana, Fernando

    2001-12-01

    Full Text Available The Dakar-Djibouti expedition, led by Marcel Griaule, crossed Africa between 1931 and 1933. One of the participants was Michel Leiris, a young poet who had just severed his relations with the surrealist avantgarde and was in the throes of a personal crisis. This paper is about his experience in that joumey of discovery of himself, of the other and of ethnography. Representation and margination: these are the themes that will endure in L'Afrique fantôme as well as in Leiris' other writings about the Dogon and the Zar cult.

    La Misión Dakar-Yibuti, bajo la dirección de Marcel Griaule, atravesó el continente africano entre 1931 y 1933. En sus filas se encontraba Michel Leiris, joven poeta que acababa de romper con la cúpula surrealista y pasaba por malos tiempos personales. Este artículo registra su experiencia en este viaje de descubrimiento de sí, del otro y de la etnografía. Representación y marginalidad, esos son los elementos que quedarán, tanto en L'Afrique fantôme como en sus otros escritos sobre los dogon y el culto zar.

  13. La enseñanza jesuita en Chile colonial: sus colegios, universidades y una aproximación a sus métodos y contenidos

    Directory of Open Access Journals (Sweden)

    Alejandra Contreras Gutiérrez

    2014-01-01

    Full Text Available El documento que se presenta a continuación tiene como objetivo informar sobre el aporte que hizo la Compañía de Jesús a la educación en Chile colonial, se proporcionará información de sus colegios, universidades, planes y métodos de estudios. La idea con esta exposición es establecer que, con la llegada de los jesuitas al país y con el inicio de las labores educativas, se instala en Chile, por primera vez, un sistema de enseñanza. La metodología que hemos empleado para este trabajo consiste en la revisión y recopilación de datos provenientes de diversos textos que son considerados clásicos en la materia, así como también de historias de la propia orden en el país, de manera que se pueda reunir toda la información que se necesita para reconstruir el panorama general de la educación jesuita en Chile. Como este tema ha sido escasamente abordado por la historiografía contemporánea nacional, este trabajo pretende ser un aporte a la historia de la educación en Chile y en América Latina, en el sentido en que la experiencia educativa jesuita en Chile fue similar a la que se experimentó en otras naciones del continente.

  14. Development of inhibitory antibodies to therapeutic factor VIII in severe hemophilia A is associated with microsatellite polymorphisms in the HMOX1 promoter

    Science.gov (United States)

    Repessé, Yohann; Peyron, Ivan; Dimitrov, Jordan D; Dasgupta, Suryasarathi; Moshai, Elika Farrokhi; Costa, Catherine; Borel-Derlon, Annie; Guillet, Benoit; D’Oiron, Roseline; Aouba, Achille; Rothschild, Chantal; Oldenburg, Johannes; Pavlova, Anna; Kaveri, Srinivas V; Lacroix-Desmazes, Sébastien

    2013-01-01

    Induction of heme oxygenase-1, a stress-inducible enzyme with anti-inflammatory activity, reduces the immunogenicity of therapeutic factor VIII in experimental hemophilia A. In humans, heme oxygenase-1 expression is modulated by polymorphisms in the promoter of the heme oxygenase-1-encoding gene (HMOX1). We investigated the relationship between polymorphisms in the HMOX1 promoter and factor VIII inhibitor development in severe hemophilia A. We performed a case-control study on 99 inhibitor-positive patients and 263 patients who did not develop inhibitors within the first 150 cumulative days of exposure to therapeutic factor VIII. Direct sequencing and DNA fragment analysis were used to study (GT)n polymorphism and single nucleotide polymorphisms located at −1135 and −413 in the promoter of HMOX1. We assessed associations between the individual allele frequencies or genotypes, and inhibitor development. Our results demonstrate that inhibitor-positive patients had a higher frequency of alleles with large (GT)n repeats (L: n≥30), which are associated with lesser heme oxygenase-1 expression (odds ratio 2.31; 95% confidence interval 1.46–3.66; P<0.001]. Six genotypes (L/L, L/M, L/S, M/M, M/S and S/S) of (GT)n repeats were identified (S: n<21; M: 21≤n<30). The genotype group including L alleles (L/L, L/M and L/S) was statistically more frequent among inhibitor-positive than inhibitor-negative patients, as compared to the other genotypes (33.3% versus 17.1%) (odds ratio 2.21, 95% confidence interval 1.30–3.76; P<0.01). To our knowledge, this is the first association identified between HMOX1 promoter polymorphism and development of anti-drug antibodies. Our study paves the way towards modulation of the endogenous anti-inflammatory machinery of hemophilia patients to reduce the risk of inhibitor development PMID:23716558

  15. Patient preference and ease of use for different coagulation factor VIII reconstitution device scenarios: a cross-sectional survey in five European countries

    Directory of Open Access Journals (Sweden)

    Cimino E

    2014-12-01

    Full Text Available Ernesto Cimino,1 Silvia Linari,2 Mara Malerba,3 Susan Halimeh,4 Francesca Biondo,5 Martina Westfeld5 1Dipartimento Medicina Clinica e Sperimentale, Universita’ degli Studi di Napoli Federico II, Naples, Italy; 2Agenzia per l’ Emofilia, AOU Careggi di Firenze, Florence, Italy; 3Fondazione Cà Granda Ospedale Maggiore Policlinico, Centro Emofilia e Trombosi “A Bianchi Bonomi”, Milan, Italy; 4CRC Coagulation Research Centre GmbH, Duisburg, Germany; 5Pfizer Italia, Rome, Italy Introduction: Hemophilia A treatment involves replacing the deficient coagulation factor VIII. This process may involve multiple steps that might create a barrier to adherence. A new dual-chamber syringe (DCS; FuseNGo® was recently introduced with the aim of simplifying reconstitution. Aim: This study aimed to identify factors associated with adult patients’ preferences for different coagulation factor VIII reconstitution systems and to test ease of use and patient preference for the DCS. Methods: A cross-sectional survey of adults with hemophilia A in five European countries was conducted; a subset of subjects also participated in a practical testing session of the DCS. Results: Among the 299 survey participants, the device scenario requiring the least equipment and reconstitution steps (the DCS received a median preference rating of 71 out of 100 (0 being “the least desirable” and 100 “the most desirable” rating. This was significantly higher than the other scenarios (the next highest achieved a median of 50 points; P<0.001. Participants would be more likely to use this device prophylactically (P<0.001. Among the 98 participants who tested the DCS, 57% preferred this device over their current device, 26% preferred their current device, and 17% had no preference. The DCS was rated as easier to use than current treatment devices (median score 9/10 versus 7/10 for current treatment, P=0.001. Conclusion: The survey indicates that the prefilled DCS, Fuse

  16. Modifications to LLNL Plutonium Packaging Systems (PuPS) to achieve ASME VIII UW-13.2(d) Requirements for the DOE Standard 3013-00 Outer Can Weld

    International Nuclear Information System (INIS)

    Riley, D; Dodson, K

    2001-01-01

    The Lawrence Livermore National Laboratory (LLNL) Plutonium Packaging System (PuPS) prepares packages to meet the DOE Standard 3013 (Reference 1). The PuPS equipment was supplied by the British Nuclear Fuels Limited (BNFL). The DOE Standard 3013 requires that the welding of the Outer Can meets ASME Section VIII Division 1 (Reference 2). ASME Section VIII references to ASME Section IX (Reference 3) for most of the welding requirements, but UW-13.2 (d) of Section VIII requires a certain depth and width of the weld. In this document the UW-13.2(d) requirement is described as the (a+b)/2t s ratio. This ratio has to be greater than or equal to one to meet the requirements of UW-13.2(d). The Outer Can welds had not been meeting this requirement. Three methods are being followed to resolve this issue: (1) Modify the welding parameters to achieve the requirement, (2) Submit a weld case to ASME that changes the UW-13.2(d) requirement for their review and approval, and (3) Change the requirements in the DOE-STD-3013. Each of these methods are being pursued. This report addresses how the first method was addressed for the LLNL PuPS. The experimental work involved adjusting the Outer Can rotational speed and the power applied to the can. These adjustments resulted in being able to achieve the ASME VIII, UW-13.2(d) requirement

  17. The Development of Geometri Teaching Materials Based on Constructivism to Improve the Students' Mathematic Reasoning Ability through Cooperative Learing Jigsaw at the Class VIII of SMP Negeri 3 Padangsidimpuan

    Science.gov (United States)

    Dewi, Izwita; Harahap, Muhammad Syahri

    2016-01-01

    The purposes of this research were to know the validity, practicality, and effectivity of geometrical learning material based on the constructivism to Increase students' mathematic reasoning ability and increasing students' mathematic reasoning ability by using learning material at the grade VIII of SMP Negeri 3 Padangsidimpuan. Type of the…

  18. Jogo (indica-sus: estratégia lúdica na aprendizagem sobre o sistema único de saude

    Directory of Open Access Journals (Sweden)

    Maria Raquel Gomes Maia Pires

    2013-01-01

    Full Text Available Es cuestionable que tecnología lúdico-educativa en el aprendizaje acerca de SUS favorece la imaginación, relajación, espontaneidad y reflexión en la formación de los profesionales de la salud. Los objetivos fueram desarrollar el juego (INDICA-SUS centrado en diálogo sobre políticas de salud con los juguetones; analizar componentes de relajación, placer, aspectos formativos, emociones y tácticas del desarrollo del (INDICA-SUS; identificar las variables indicativas de lo lúdico en tecnologías educativas para la salud. Enfoque exploratorio, descriptivo, cuantitativo y cualitativo, estudio de caso. Las pruebas se realizaron con partidas testes de 180 participantes, cuestionarios, observación participante, análisis de contenido y prueba estadística de Pearson. Las variables indicativas de ludicidad de tecnologías de educación para la salud incluyen placer y tensión en el juego. El (INDICA-SUS integra carácter inventivo, imaginativo e de intercambio como potencial para la formación; contemplase aprendizaje múltiple y el enseño del SUS, a partir de él.

  19. [The Citizen Constitution and the 25th anniversary of the Brazilian Unified National Health System (SUS)].

    Science.gov (United States)

    Paim, Jairnilson Silva

    2013-10-01

    This article, celebrating the 25th anniversary of Brazil's 1988 Constitution, aims to review the country's social policy development, discuss political projects, and analyze challenges for the sustainability of the Unified National Health System (SUS). Based on public policymaking studies, the article revisits the origins of liberal social policy, focused on social assistance, and analyzes the hegemony of U.S. policies targeting poverty and their repercussions for universal policies. After identifying the formulation of political projects in Brazil's democratic transition, it discusses their implications during the various Administrations since 1988, along with the difficulties faced by the National Health System. The article concludes that the political forces occupying government in the last two decades have failed to present a project for the country on the same level as those who drafted the Citizen Constitution.

  20. Sexualidad -[es]- en la escuela: en las voces de sus protagonistas

    OpenAIRE

    Montaña, Alejandra Érica

    2012-01-01

    Con la sanción de la ley 26150 y la inclusión formal de la Educación SexualIntegral en el ámbito educativo, se pone nuevamente en debate la construcción de la sexualidad y su estrecha relación con la construcción de subjetividades como parte del proceso educativo.En este artículo se trabaja con la reconstrucción de los relatos biográficos de docentes que asistieron a diferentes capacitaciones sobre Educación Sexual Integral. Desde sus voces, se aspira a recuperar percepciones de su propia sex...

  1. Effect of titanium on microstructural changes in SUS 316 stainless steels

    International Nuclear Information System (INIS)

    Kawanishi, H.; Yamada, M.; Fukuya, K.; Ishino, S.

    1982-01-01

    The microstructural changes have been examined in order to study the effect of titanium addition to type 316 stainless steels on void swelling. Titanium ions of 400 keV from an accelerator have been implanted at room temperature to solution treated SUS 316 stainless steels which have the original titanium content of 0.02 wt.% to the concentration increase of titanium by 0.01, 0.02 and 0.1 wt.%. Following the preinjection of 20 at.ppm helium at ambient temperature, 400 keV-aluminium ions have been irradiated to the specimen to 40 dpa at 550, 625 and 675 0 C. The TEM observations have revealed that the void number density is drastically increased in the specimen with the content of implanted titanium of more than 0.01 wt.%, whereas the void diameter is remarkably decreased with the titanium content. (orig.)

  2. Microsatellite markers for identification and parentage analysis in the European wild boar (Sus scrofa

    Directory of Open Access Journals (Sweden)

    Costa Vânia

    2012-09-01

    Full Text Available Abstract Background The wild boar (Sus scrofa is among the most widespread mammal species throughout the old world. Presently, studies concerning microsatellites in domestic pigs and wild boars have been carried out in order to investigate domestication, social behavior and general diversity patterns among either populations or breeds. The purpose of the current study is to develop a robust set of microsatellites markers for parentage analyses and individual identification. Findings A set of 14 previously reported microsatellites markers have been optimized and tested in three populations from Hungary, Portugal and Spain, in a total of 167 samples. The results indicate high probabilities of exclusion (0.99999, low probability of identity (2.0E-13 – 2.5E-9 and a parentage assignment of 100%. Conclusions Our results demonstrate that this set of markers is a useful and efficient tool for the individual identification and parentage assignment in wild boars.

  3. Seroepidemiologic survey for Chlamydia suis in wild boar (Sus scrofa) populations in Italy.

    Science.gov (United States)

    Di Francesco, Antonietta; Donati, Manuela; Morandi, Federico; Renzi, Maria; Masia, Marco Antonio; Ostanello, Fabio; Salvatore, Daniela; Cevenini, Roberto; Baldelli, Raffaella

    2011-07-01

    We used serology to estimate the prevalence of exposure to chlamydiae in Italian populations of wild boars (Sus scrofa). Sera from 173 hunter-killed wild boars harvested during the 2006-2009 hunting seasons in three Italian regions were tested for antibodies to Chlamydia suis, Chlamydophila pecorum, Chlamydophila abortus, and Chlamydophila psittaci by the microimmunofluorescence test. Antibody titers to chlamydiae ≥ 1:32 were detected in 110 of the 173 samples tested (63.6%). Specific reactivity could be assessed only in 44 sera with antibody titers to C. suis that were two- to threefold higher than antibody titers against the other chlamydial species; the other 66 sera had similar reactivity against all the chlamydia species tested. Antibody to C. suis was detected in sera from wild boar populations with rare or no known contact with domestic pigs. These results suggest that the wild boar could be a chlamydia reservoir and may acquire chlamydiae independent of contacts with the domestic pig.

  4. Shifts in soil biodiversity-A forensic comparison between Sus scrofa domesticus and vegetation decomposition.

    Science.gov (United States)

    Olakanye, Ayodeji O; Thompson, Tim; Ralebitso-Senior, T Komang

    2015-12-01

    In a forensic context, microbial-mediated cadaver decomposition and nutrient recycling cannot be overlooked. As a result, forensic ecogenomics research has intensified to gain a better understanding of cadaver/soil ecology interactions as a powerful potential tool for forensic practitioners. For this study, domestic pig (Sus scrofa domesticus) (4g) and grass (Agrostis/Festuca spp) cuttings (4g) were buried (July 2013 to July 2014) in sandy clay loam (80 g) triplicates in sealed microcosms (127 ml; 50 × 70 cm) with parallel soil only controls. The effects of the two carbon sources were determined by monitoring key environmental factors and changes in soil bacterial (16S rRNA gene) and fungal (18S rRNA gene) biodiversity. Soil pH changes showed statistically significant differences (p0.05) was observed between the treatments. Copyright © 2015 The Chartered Society of Forensic Sciences. Published by Elsevier Ireland Ltd. All rights reserved.

  5. La personalidad y sus trastornos desde una perspectiva sistémica

    Directory of Open Access Journals (Sweden)

    Juan Luis Linares

    2007-01-01

    Full Text Available La personalidad puede ser definida como la dimensión individual de la experiencia relacional acumulada, en diálogo entre pasado y presente y doblemente contextualizada por un substrato biológico y un marco cultural. La nutrición relacional es el motor que construye la personalidad, partiendo de una narrativa de la que se segrega la identidad, en estrecho contacto con la organización y la mitología de los sistemas de pertenencia y muy especialmente de la familia de origen. Las dos grandes dimensiones que definen la atmósfera relacional de ésta, la conyugalidad y la parentalidad, delimitan tres áreas de disfuncionalidad, a saber, las triangulaciones, las deprivaciones y las caotizaciones, en las que sientan sus bases los diversos trastornos de personalidad.

  6. Los numeros monograficos de la Revista Latinoamericana de Psicologia en sus 30 años

    OpenAIRE

    Jhon J. Sanabria

    1998-01-01

    En el presente escrito se revisan los números monográficos de la Revista Latinoamericana de Psicología en sus 30 años. Se propone una clasificación en cuatro grupos: temáticas de la psicología general, estado de la psicología en algún país de Latinoamérica, problemasde relevancia social relacionados con la psicología, y números conmemorativos de la propia revista. Finalmente se plantea cuál es la importancia de estos números tanto en su momento de publicación como más tarde....

  7. El control selectivo de las fronteras y la transnacionalización de sus resistencias

    Directory of Open Access Journals (Sweden)

    Barbero González, Iker

    2010-08-01

    Full Text Available This article deals with an emergent phenomenon, the transnational networks in advocacy of immigrants’ rights. As a conjunction of multiple organizations (immigrant associations, NGOs, anti-globalization groups, trade unions..., these networks have realised the necessity of transnationalizing their action in order to defeat the European Union neoliberal policies of border control and labour supply.

    Este artículo trata un fenómeno relativamente reciente: las redes transnacionales por los derechos de los inmigrantes. Refiere a la confluencia de múltiples organizaciones (asociaciones inmigrantes, ONGs, grupos anti-globalización, sindicatos, etc., quienes son conscientes de la necesidad de transnacionalizar sus acciones de cara a contrarrestar las políticas neoliberales de control de fronteras y provisión de mano de obra provenientes desde la Unión Europea.

  8. El experimento mago de Oz y sus aplicaciones: una mirada retrospectiva

    Directory of Open Access Journals (Sweden)

    CARLOS M. ZAPATA

    2007-01-01

    Full Text Available En la Lingüística Computacional los corpus han sido uno de los recursos más utilizados para estudiar los diferentes fenómenos lingüísticos. La recopilación de corpus en los cuales se presenta interacción entre el humano y el computador presenta como problema fundamental los errores que se pueden inducir por parte del humano, cuyo lenguaje se simplifica en presencia del computador. Para realizar la recopilación de estos corpus se han empleado los Experimentos Mago de Oz (MDO. En este artículo se muestra una mirada retrospectiva del Experimento Mago de Oz, clasificando sus principales aplicaciones.

  9. Nostalgia por la escuela rural en los recuerdos de sus antiguos estudiantes

    Directory of Open Access Journals (Sweden)

    Mercedes Suárez Pazos

    2011-01-01

    Full Text Available El objetivo es conocer a través del análisis de los recuerdos de antiguos estudiantes de escuelas rurales gallegas el papel que ocupaban en sus recuerdos y el significado del cambio de centro. Los narradores han establecido las diferencias vividas por ellos en su paso a los grupos escolares o a los colegios de religiosos. A pesar de que estos edificios poseen mejores instalaciones y mobiliario, estas ventajas no logran ocultar, a los ojos de los narradores, la consolidación del modelo de escuela cerrada. Y es la otra escuela, la que perdieron, junto con la su infancia, la que los narradores añoran.

  10. GLOBALIZACIÓN Y CIENCIA ECONÓMICA: APUNTES SOBRE MUCHAS EQUIVOCACIONES Y SUS REPETICIONES

    Directory of Open Access Journals (Sweden)

    Theotonio dos Santos

    2007-07-01

    Full Text Available Este trabajo defiende la tesis de que la ciencia económica, bajo la forma del mainstrean neoliberal se convirtió en un obstáculo para la comprensión del sistema económico mundial. Sus recomendaciones buscan limitar el crecimiento económico en los países centrales y lanza las zonas dependientes en gran crisis. Esto ocurre en un momento de gran potencial de crecimiento, una nueva fase la de los ciclos largos de Kondratiev basada en las innovaciones generadas por la revolución técnico-científica. Se compara la ciencia económica actual a la Escolástica medieval que se convirtió en el obstáculo principal para la gran ofensiva modernizadora iniciada en el renacimiento.

  11. Seroprevalence of Neospora caninum in feral swine (Sus scrofa) in the United States.

    Science.gov (United States)

    Cerqueira-Cézar, Camila K; Pedersen, Kerri; Calero-Bernal, Rafael; Kwok, Oliver C; Villena, Isabelle; Dubey, Jitender P

    2016-08-15

    The protozoon Neospora caninum is a major cause of abortion in cattle worldwide. Canids (Canis familiaris, Canis latrans, Canis lupus) are definitive hosts whereas many other animal species, including pigs, are intermediate hosts for the parasite. Between 2012 and 2014, serum samples from 1059 feral swine (Sus scrofa) from 29 states of the USA were tested for N. caninum antibodies, using the N. caninum agglutination test (NAT). Of these, 159 (15.0%) feral pigs from 21 states tested positive, with a range of titers of 1:25 (cut-off) (n=153), 1:200 (1), 1:400 (1), 1:800 (3) and 1:3200 (1). Results indicate widespread exposure of feral swine to N. caninum infection across the USA. Published by Elsevier B.V.

  12. La reforma constitucional y sus efectos en las relaciones Iglesia-Estado

    Directory of Open Access Journals (Sweden)

    María del Carmen García Aguilar

    2004-02-01

    Full Text Available A poco más de una década de la reforma de los artículos constitucionales 3º, 5º, 24, 27, y 130, esta comunicación intenta identificar los impactos sociopolíticos gestados por esta nueva legalidad en las relaciones Estado-iglesias. La reforma constitucional de 1992 que dota de personalidad jurídica a las instituciones religiosas y las iguala con las asociaciones civiles en derechos y obligaciones, marca un punto de inflexión no sólo en los enfoques del estudio de las instituciones eclesiales sino también, en el hecho religioso mismo y sus prácticas en Chiapas.

  13. La radio y sus sounds como maquinaria literaria: el estridentismo mexicano y su historia radial

    OpenAIRE

    Christiane Quandt

    2016-01-01

    La radio y el Estridentismo mexicanos se estrenan en el año 1921. Los estridentistas, entre ellos Luis Quintanilla (Kyn-Taniya), Germán List Arzubide, Arqueles Vela y Manuel Maples Arce, estaban fascinados por la transmisión inalámbrica, sus sonidos y ruidos. Esto dejaría huella en su producción poética. A la vez, el grupo colaboró con una de las primeras estaciones de radio en México. Es así que la metáfora radiofónica se encuentra en su poesía y se materializa con la transmisión de ”T.S.H.”...

  14. A comparative study of Sus scrofa M. longissimus dorsi with different changes in quality

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    Irina Mikhailovna Chernukha

    2017-01-01

    Full Text Available The comparative study of Sus scrofa muscle tissue with different defects of quality was carried out. Such analysis methods as determination of water-binding capacity (WBC and pH values, microstructural studies, proteome methods, mass spectrometric methods, high performance liquid chromatography (HPLC and determine the concentration of cathepsin D, calpain 3 and myoglobin were applied in current study. DFD meat was characterized by high pH (6.2 and WBC (93.18%, while PSE - low pH (5.5 and WBC (79.19%. pH and WBC values in NOR pork was medium and averaged 5.9 and 92.05%, respectively. Microstructural studies revealed that fiber in exudative pork was the least and averaged 39.7 µm, normal pork was characterized by diameter of muscle of 45.5 µm, while DFD pork ‑ 48.3 µm. Protein composition of Sus scrofa muscle tissues were also investigated by one-dimensional and two-dimensional electrophoresis. 6 protein fractions were identified by mass spectrometry and confirmed as potential biomarkers of pork quality defects in meat and processes meat product. It also has been shown that PSE pork contains 8 characteristic peptides, NOR - 14, DFD - 18. Cathepsin D, calpain 3 and myoglobin content were measured in pork of different categories. The highest content of cathepsin D, calpain 3 and myoglobin was noticed in PSE pork and averaged 82.16 ±3.30 ng.mL-1; 1.280 ±0.082 ng.mL-1; 3.973 ±0.506 ng.mL-1, respectively. Since the study was carried out on samples of meat 24 hours after slaughter, this work had the prospect to further study of meat with different defects of quality during long-term autolysis.

  15. Representação social do terapeuta comunitário na rede SUS

    Directory of Open Access Journals (Sweden)

    Cristina dos Santos Padilha

    2013-08-01

    Full Text Available A aprovação da Política Nacional de Práticas Integrativas e Complementares dá subsídios para implantar a Terapia Comunitária no Sistema Único de Saúde (SUS, visando desenvolver nos profissionais e nas lideranças comunitárias as competências necessárias para lidar com as demandas psicossociais e promover redes de apoio social, ampliando a resolutividade da Atenção Básica. O objetivo deste estudo é descrever a representação social sobre o Terapeuta comunitário elaborada por profissionais de saúde da rede SUS. Participaram 27 profissionais que realizaram a formação em Terapia Comunitária oferecida em 2009 pela Secretaria de Estado da Saúde de Santa Catarina em parceria com o Ministério da Saúde. A coleta de dados utilizou a entrevista individual semidirigida e a análise foi realizada por meio da classificação hierárquica descendente. Os resultados revelam que existe uma representação social dos profissionais sobre o que é ser terapeuta comunitário, entendido como alguém que humaniza as relações interpessoais no setor saúde. No entanto, os profissionais da Atenção Primária são legatários de um modelo de prática grupal menos horizontalizado que os profissionais da Atenção Secundária, nesse trabalho representada pelos Centros de Atenção Psicossocial (CAPS.

  16. Temperature dependence of the minimum V/III ratio for the growth of In[sub x]Ga[sub 1-x]As

    Energy Technology Data Exchange (ETDEWEB)

    Riechert, H. (Siemens Corporate Research and Development, Muenchen (Germany)); Averbeck, R. (Siemens Corporate Research and Development, Muenchen (Germany)); Bernklau, D. (Siemens Corporate Research and Development, Muenchen (Germany))

    1993-02-01

    We have quantitatively determined the minimum V/III ratios for the growth of In[sub x]Ga[sub 1-x]As(x=0, 0.1, 0.2 and 0.53) on GaAs and InP. Minimum As[sub 4] fluxes were measured for a wide range of growth temperatures using a transition of the surface reconstruction. Their temperature dependence can be fitted very well by the typical curve for thermally activated behavior. We find In[sub x]Ga[sub 1-x]As and GaAs are found to be similar (1.9 and 2.1 eV, respectively) but the rates of As-desorption are much higher for In[sub x]Ga[sub 1-x]As. This may be seen as evidence for a less effective dissociative reaction of As[sub 4] with In than with Ga. (orig.)

  17. Bianchi - I, II, VIII, IX and Kantowski-Sachs-like cosmological models with perfect fluid and electromagnetic fields with conductivity current

    International Nuclear Information System (INIS)

    Portugal, R.

    1984-01-01

    Three processes of solutions of the Einstein-Maxwell equations for Bianchi - I, II, VIII, IX and Kantowski-Sachs-like cosmological models with perfect fluid in magnetohydrolodynamical regimem are presented. Diagonal Bianchi-like models are considered with two anisotropy direction in the maximum. Solutions are found for Bianchi-II and IX-like models with energy conditions to be analyzed. Solutions are found for Bianchi-IX and Kantowski-Sachs-Like models with positive electric conductivity and satisfering to the predominant energy conditions. Solutions are formed for isotropic Kantowski-Sachs-Like models satisfering to the equation of state p=λρ, 0 0, admiting, in addition to the perfect fluid, electric field only. It is shown that a class of Bertotti-Robinson-like solutions is unstable by perturbations and it is carried in Kantowski-Sachs-like models with non-null electric conductivity. (L.C.) [pt

  18. A disputa entre o Papa Bonifácio VIII e o Rei Filipe IV no final do século XIII

    Directory of Open Access Journals (Sweden)

    Strefling, Sérgio Ricardo

    2007-01-01

    Full Text Available A questão das relações entre Igreja e Estado provocou debates prolongados e acesos, principalmente durante a idade média, no momento em que a igreja, dotada de um domínio próprio temporal, encontrava-se em convívio com o Sacro Império Romano que abraçava os mesmos súditos e apoiava-se sobre bases jurídicas derivadas do Cristianismo. Sob tal situação ainda era possível manter uma diferenciação entre estado e Igreja? No presente estudo, apresentaremos a polêmica causada pela teoria do Papa Bonifácio VIII no conflito com o Rei Filipe, o Belo. Daí surgem três documentos importantes, entre eles, a Bula Unam Sanctam

  19. Pandangan Hakim Pengadilan Agama Palembang Terhadap Putusan Mahkamah Konstitusi Nomor 46/PUU-VIII/2010 Tentang Status Anak di Luar Nikah

    Directory of Open Access Journals (Sweden)

    Arne Huzaimah

    2016-03-01

    Full Text Available Penelitian ini mengkaji tentang status anak di luar nikah perpektif hukum Islam. Pertimbangan Hukum Majelis Hakim Mahkamah Konstitusi Nomor: 46/PUU-VIII/201. Pandangan Hakim Pengadilan Agama Kelas 1A Palembang terhadap Putusan Mahkamah Konstitusi Nomor: 46/PUU-VIII/2010 adalah: Putusan uji materi pasal 43 ayat 1 UUP, sesungguhnya ditujukan untuk anak yang lahir di luar perkawinan akibat nikah sirri atau kumpul kebo. Berdasarkan penetapan pengadilan agama yang berkaitan dengan pengesahan perkawinan/itsbat nikah dan penetapan asal usul anak, maka anak yang dilahirkan dari perkawinan sirri dapat dinyatakan sebagai anak yang sah. Dengan status anak sah, maka anak tersebut mempunyai hubungan perdata dengan ayah biologisnya. Hubungan perdata yang timbul akibat dari adanya hubungan darah ini meliputi hubungan hukum, hak dan kewajiban antara anak dengan ayah dan ibunya yang dapat berupa:  (1  hubungan  nasab;  (2  hubungan mahram; (3 hubungan hak dan kewajiban; (4 hubungan pewarisan (saling mewarisi  yang  merupakan  pelanjutan  hubungan  hak  dan  kewajiban karena  nasab  ketika mereka  sama-sama masih  hidup;  dan  (5  hubungan wali nikah antara ayah dengan anak perempuannya. This paper examined the status of children outside wedlock in perspective of Islamic law. Consideration of the judges of the Constitutional Court Law No. 46 / PUU-VIII / 2010: included: the right to obtain legal status of the child; registration of marriage was not a factor in determining the legal of the marriage and registration of marriages was an administrative obligations required by legislation. The factors that determined the legal of a marriage was the conditions prescribed by the religion of each pair bride; problems concerned children born out of wedlock should receive law protection and law certainty to the status of a child born and rights available to him, including toward children born though the legal of the marriage still disputed. While the

  20. Cacotheline as an oxidimetric reagent. Determination of Sn(II), Cu(I), Ti(III), Fe(II), V(II) and V(III)

    International Nuclear Information System (INIS)

    Nemani Murty, K.; Yedluri Rao, P.; Geddada Chalam, K.

    1982-01-01

    Sn(II), Ti(III), Cu(I),Fe(II), V(III) and V(II) can be titrated potentiometrically with cacotheline in 1-4 M hydrochloric acid, 0.5-2 M hydrochloric acid, 0.5-1.5 M sulphuric acid in presence of 4 ml of 10% EDTA solution in a total volume of 50 ml, 9-10 M phosphoric acid, 4-8 M acetic acid and 3-8 M acetic acid respectively. Cacotheline can be used for the assay of tin plate and solder. The cacotheline undergoes a 2-electron reduction reaction. A cacotheline solution (0.005 M) in 0.02 M hydrochloric acid is fairly stable for several months. The conditional redox potentials of cacotheline have been determined in sulphuric, phosphoric and acetic acid medium. (Author)

  1. Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia

    DEFF Research Database (Denmark)

    Larsen, Malte Selch; Juul, Rasmus Vestergaard; Groth, Andreas Velsing

    2018-01-01

    for nonlinear kinetics and gender-specific difference in clearance for rFVIII. The predictive performance of the animal population PK models of rFVIIa and rFVIII revealed significant species-variation. The developed PK models of rFVIIa and rFVIII in monkeys and dogs along with allometric interspecies scaling......Various experimental animal models are used in haemophilia research, however, little is known about how well the different species predict pharmacokinetic (PK) profiles in haemophilia patients. The aim of the current study was to describe the plasma concentration-time profile of recombinant...... activated factor VII (rFVIIa) and recombinant factor VIII (rFVIII) in several experimental animal models using population PK modelling, and apply a simulation-based approach to evaluate how well the developed animal population PK models predict human PK. PK models were developed for rFVIIa and r...

  2. Tartaglia’s science of weights and mechanics in the sixteenth century selections from quesiti et inventioni diverse books VII–VIII

    CERN Document Server

    Pisano, Raffaele

    2016-01-01

    This book presents a historical and scientific analysis as historical epistemology of the science of weights and mechanics in the sixteenth century, particularly as developed by Tartaglia in his Quesiti et inventioni diverse, Book VII and Book VIII (1546; 1554). In the early 16th century mechanics was concerned mainly with what is now called statics and was referred to as the Scientia de ponderibus, generally pursued by two very different approaches. The first was usually referred to as Aristotelian, where the equilibrium of bodies was set as a balance of opposite tendencies to motion. The second, usually referred to as Archimedean, identified statics with centrobarica, the theory of centres of gravity based on symmetry considerations. In between the two traditions the Italian scholar Niccolò Fontana, better known as Tartaglia (1500?–1557), wrote the treatise Quesiti et inventioni diverse (1546). This volume consists of three main parts. In the first, a historical excursus regarding Tartaglia’s lifetime,...

  3. Influence of the V/III ratio in the gas phase on thin epitaxial AlN layers grown on (0001) sapphire by high temperature hydride vapor phase epitaxy

    Energy Technology Data Exchange (ETDEWEB)

    Claudel, A., E-mail: arnaud.claudel@grenoble-inp.org [ACERDE, 354 Voie Magellan — Alpespace, 73800 Ste Hélène du Lac (France); Fellmann, V. [ACERDE, 354 Voie Magellan — Alpespace, 73800 Ste Hélène du Lac (France); Science et Ingénierie des Matériaux et des Procédés, Grenoble INP-CNRS-UJF, BP 75, 38402 Saint Martin d' Hères (France); Gélard, I. [ACERDE, 354 Voie Magellan — Alpespace, 73800 Ste Hélène du Lac (France); Coudurier, N. [ACERDE, 354 Voie Magellan — Alpespace, 73800 Ste Hélène du Lac (France); Science et Ingénierie des Matériaux et des Procédés, Grenoble INP-CNRS-UJF, BP 75, 38402 Saint Martin d' Hères (France); Sauvage, D. [ACERDE, 354 Voie Magellan — Alpespace, 73800 Ste Hélène du Lac (France); Balaji, M. [ACERDE, 354 Voie Magellan — Alpespace, 73800 Ste Hélène du Lac (France); Science et Ingénierie des Matériaux et des Procédés, Grenoble INP-CNRS-UJF, BP 75, 38402 Saint Martin d' Hères (France); Crystal Growth Center, Anna University, Chennai 600025 (India); and others

    2014-12-31

    Thin (0001) epitaxial aluminum nitride (AlN) layers were grown on c-plane sapphire using high temperature hydride vapor phase epitaxy. The experimental set-up consists of a vertical cold-wall quartz reactor working at low pressure in which the reactions take place on a susceptor heated by induction. The reactants used are ammonia and aluminum chlorides in situ formed via hydrogen chloride reaction with high purity aluminum pellets. As-grown AlN layers have been characterized by scanning electron microscopy, atomic force microscopy, X-ray diffraction, transmission electron microscopy, photoluminescence and Raman spectroscopies. The influence of the V/III ratio in the gas phase, from 1.5 to 15, on growth rate, surface morphology, roughness and crystalline quality is investigated in order to increase the quality of thin epitaxial AlN layers grown at high temperature. Typical growth rates of around 0.45 μm/h were obtained for such thin epitaxial AlN layers. The growth rate was unaffected by the V/III ratio. An optimum for roughness, crystalline quality and optical properties seems to exist at V/III = 7.5. As a matter of fact, for a V/III ratio of 7.5, best root mean square roughness and crystalline quality — measured on 0002 symmetric reflection — as low as 6.9 nm and 898 arcsec were obtained, respectively. - Highlights: • Growth of thin epitaxial AlN layers by high temperature hydride vapor phase epitaxy • Influence of V/III ratio on growth rate, morphology and crystalline quality • The effect of surface morphology on strain state and crystal quality is established.

  4. Oral manifestations, dental management, and a rare homozygous mutation of the PRDM12 gene in a boy with hereditary sensory and autonomic neuropathy type VIII: a case report and review of the literature.

    Science.gov (United States)

    Elhennawy, Karim; Reda, Seif; Finke, Christian; Graul-Neumann, Luitgard; Jost-Brinkmann, Paul-Georg; Bartzela, Theodosia

    2017-08-15

    Hereditary sensory and autonomic neuropathy type VIII is a rare autosomal recessive inherited disorder. Chen et al. recently identified the causative gene and characterized biallelic mutations in the PR domain-containing protein 12 gene, which plays a role in the development of pain-sensing nerve cells. Our patient's family was included in Chen and colleagues' study. We performed a literature review of the PubMed library (January 1985 to December 2016) on hereditary sensory and autonomic neuropathy type I to VIII genetic disorders and their orofacial manifestations. This case report is the first to describe the oral manifestations, and their treatment, of the recently discovered hereditary sensory and autonomic neuropathy type VIII in the medical and dental literature. We report on the oral manifestations and dental management of an 8-month-old white boy with hereditary sensory and autonomic neuropathy-VIII over a period of 16 years. Our patient was homozygous for a mutation of PR domain-containing protein 12 gene and was characterized by insensitivity to pain and thermal stimuli, self-mutilation behavior, reduced sweat and tear production, absence of corneal reflexes, and multiple skin and bone infections. Oral manifestations included premature loss of teeth, associated with dental traumata and self-mutilation, severe soft tissue injuries, dental caries and submucosal abscesses, hypomineralization of primary teeth, and mandibular osteomyelitis. The lack of scientific knowledge on hereditary sensory and autonomic neuropathy due to the rarity of the disease often results in a delay in diagnosis, which is of substantial importance for the prevention of many complications and symptoms. Interdisciplinary work of specialized medical and dental teams and development of a standardized treatment protocols are essential for the management of the disease. There are many knowledge gaps concerning the management of patients with hereditary sensory and autonomic neuropathy-VIII

  5. Sucesos estresantes y sus impactos en mujeres y jóvenes de la comunidad de cuitzeo, Michoacán: El ciclo de la migración México-EUA en sus familias

    Directory of Open Access Journals (Sweden)

    Nydia Obregón-Velasco

    Full Text Available El presente trabajo describe algunos sucesos de vida estresantes y los impactos que tienen en la salud de las mujeres y sus hijos jóvenes, a partir de la migración hacia EUA de algunos de sus familiares directos, lo cual favorece el ciclo de migración en la familia. Se utilizó la metodología cualitativa con un enfoque de participación-acción, aplicando grupos focales, entrevistas y observación participante durante diferentes actividades realizadas en la comunidad de Cuitzeo, Michoacán, tales como conferencias y talleres.

  6. Iconoclasmo e iconodulia entre oriente y occidente (siglos VIII-IX Iconoclasm and iconoduly between east and west (8th-9th centuries

    Directory of Open Access Journals (Sweden)

    Alfonso Hernández Rodríguez

    2011-10-01

    Full Text Available El siguiente artículo trata acerca de la recepción en el occidente carolingio de la crisis iconoclasta. Reflexiona sobre la forma en que ambas cristiandades trataron el problema que las imágenes representan para las prácticas religiosas y las consecuencias políticas del culto de los iconos. El escrito afirma también que durante los siglos VIII y IX la crisis iconoclasta permitió la aparición de una tradición cristiana latina consciente de sí misma. Por lo tanto, se trató del momento que puso en evidencia el nacimiento de dos formas divergentes de piedad cristiana y la alienación de una respecto de la otra. La cristiandad occidental centrada en el edificio eclesiástico y que privilegiaba la ubicación de lo sagrado en el rito eucarístico, y la oriental cuyo centro era la adoración de las imágenes, con la consecuente multiplicación de los espacios sagrados.The following paper deals with the reception in the Carolingian west of the Byzantine Iconoclast Crisis. It considers the way both Christianities dealed with the problem that images presented to religious practices and the political consequences of iconic worship. The paper also states that during the VIII and IX centuries the iconoclast crisis allowed the emergence of a self conscious Latin Christian tradition. Consequently it was the moment that showed the beginning of two differing ways of Christian piety and the alienation of one towards the other. Western Christianity focused its religion practice in church building and the idea of Sacrality in the Eucharistic Rite. The oriental church, moreovers, centered its practices and theology on icon worship.

  7. Murine leukemia virus-derived retroviral vector has differential integration patterns in human cell lines used to produce recombinant factor VIII

    Directory of Open Access Journals (Sweden)

    Marcela Cristina Correa de Freitas

    2014-06-01

    Full Text Available OBJECTIVE: Nowadays recombinant factor VIII is produced in murine cells including in Chinese hamster ovary (CHO and baby hamster kidney cells (BHK. Previous studies, using the murine leukemia virus-derived retroviral vector pMFG-FVIII-P140K, modified two recombinant human cell lines, HepG2 and Hek293 to produce recombinant factor VIII. In order to characterize these cells, the present study aimed to analyze the integration pattern of retroviral vector pMFG-FVIII-P140K.METHODS: This study used ligation-mediated polymerase chain reaction to locate the site of viral vector integration by sequencing polymerase chain reaction products. The sequences were compared to genomic databases to characterize respective clones.RESULTS: The retroviral vector presented different and non-random profiles of integration between cells lines. A preference of integration for chromosomes 19, 17 and 11 was observed for HepG2FVIIIdB/P140K and chromosome 9 for Hek293FVIIIdB/P140K. In genomic regions such as CpG islands and transcription factor binding sites, there was no difference in the integration profiles for both cell lines. Integration in intronic regions of encoding protein genes (RefSeq genes was also observed in both cell lines. Twenty percent of integrations occurred at fragile sites in the genome of the HepG2 cell line and 17% in Hek293.CONCLUSION: The results suggest that the cell type can affect the profile of chromosomal integration of the retroviral vector used; these differences may interfere in the level of expression of recombinant proteins.

  8. Invención y tradición en la cancillería real de Alfonso VIII de Castilla (1158-1214

    Directory of Open Access Journals (Sweden)

    Pablo Martín Prieto

    2013-11-01

    Full Text Available El estudio de la evolución de la cancillería real de Castilla bajo Alfonso VIII permite derivar ciertas conclusiones sobre el papel individual de los miembros de su personal en la redacción de los diplomas regios, concretamente por medio de un análisis detenido de los preámbulos, su formación y alteraciones a lo largo del tiempo en la mano de los distintos scriptores. Asimismo, esta base permite medir el equilibrio entre tradición e innovación en el trabajo de cancillería. La consideración de la imagen del monarca ideal, tal como se propone tanto en fuentes literarias como en los mismos documentos de la cancillería, conduce a una comprensión más clara del alcance de la propaganda política de la época en el más amplio contexto cultural de la corte castellana.The study of the Castilian royal Chancery’s evolution under King Alfonso VIII allows us to draw certain conclusions on the role of individual members of that office in the process of drafting royal documents. We will present a detailed description of preambles, their elaboration and evolution in time and by the hands of different scriptores. This will also allow us to gauge the balance between tradition and innovation within the Chancery. A more thorough grasp of the scope of political propaganda at the time can be determined through the image of the ideal king as depicted both in literary sources and in Chancery documents within the wider context of cultural developments in the Castilian court.

  9. A solvent/detergent-treated and 15-nm filtered factor VIII: a new safety standard for plasma-derived coagulation factor concentrates.

    Science.gov (United States)

    Chtourou, S; Porte, P; Nogré, M; Bihoreau, N; Cheesman, E; Samor, B; Sauger, A; Raut, S; Mazurier, C

    2007-05-01

    Since the early 1990 s the Committee for Proprietary Medicinal Products has set the mandatory requirement that all manufacturing processes for blood products include two virus removal/inactivation steps that are complementary in their action. The objective was to develop a manufacturing process for factor VIII (FVIII) including two complementary steps of viral inactivation/elimination. A 35-15 nm nanofiltration step was added to a former FVIII manufacturing process that included solvent/detergent (S/D) treatment to generate a new FVIII concentrate called Factane. The impact of nanofiltration on the structural and functional characteristics of FVIII, as well as virus/transmissible spongiform encephalopathy reduction factors were assessed. Using an innovative approach, FVIII was successfully nanofiltered at 35-15 nm, while the biological properties of the active substance were unmodified. FVIII coagulant and antigen content for Factane and previous S/D-treated FVIII (FVIII-LFB, commercialized as Facteur VIII-LFB) were comparable. The FVIII one-stage chromogenic and coagulant/antigen ratios confirmed that nanofiltered FVIII was not activated. After nanofiltration, the copurified von Willebrand factor (vWF) was reduced but vWF/FVIII binding properties were unaffected. Phospholipid binding and thrombin proteolysis studies displayed no differences between Factane and FVIII-LFB. The rate of factor Xa generation was slightly lower for Factane when compared to FVIII-LFB. Viral validation studies with different viruses showed no detectable virus in the filtrate. Nanofiltration of FVIII at 15 nm is feasible despite the large molecular weight of FVIII and vWF. Nanofiltration has been proven to be highly effective at removing infectious agents while preserving the structural and functional integrity of FVIII.

  10. Driven equilibrium (drive) MR imaging of the cranial nerves V-VIII: comparison with the T2-weighted 3D TSE sequence

    International Nuclear Information System (INIS)

    Ciftci, E.; Anik, Yonca; Arslan, Arzu; Akansel, Gur; Sarisoy, Tahsin; Demirci, Ali

    2004-01-01

    Purpose: The aim of this study is to evaluate the efficacy of the driven equilibrium radio frequency reset pulse (DRIVE) on image quality and nerve detection when used in adjunction with T2-weighted 3D turbo spin-echo (TSE) sequence. Materials and methods: Forty-five patients with cranial nerve symptoms referable to the cerebellopontine angle (CPA) were examined using a T2-weighted 3D TSE pulse sequence with and without DRIVE. MR imaging was performed on a 1.5-T MRI scanner. In addition to the axial resource images, reformatted oblique sagittal, oblique coronal and maximum intensity projection (MIP) images of the inner ear were evaluated. The nerve identification and image quality were graded for the cranial nerves V-VIII as well as inner ear structures. These structures were chosen because fluid-solid interfaces existed due to the CSF around (the cranial nerves V-VIII) or the endolymph within (the inner ear structures). Statistical analysis was performed using the Wilcoxon test. P<0.05 was considered significant. Results: The addition of the DRIVE pulse shortens the scan time by 25%. T2-weighted 3D TSE sequence with DRIVE performed slightly better than the T2-weighted 3D TSE sequence without DRIVE in identifying the individual nerves. The image quality was also slightly better with DRIVE. Conclusion: The addition of the DRIVE pulse to the T2-weighted 3D TSE sequence is preferable when imaging the cranial nerves surrounded by the CSF, or fluid-filled structures because of shorter scan time and better image quality due to reduced flow artifacts

  11. ANALISIS MAQÂṢID ASY-SYARÎ’AH TERHADAP PUTUSAN MK NOMOR 46/PUU-VIII/2010 DAN IMPLIKASINYA TERHADAP HUKUM KELUARGA ISLAM DI INDONESIA

    Directory of Open Access Journals (Sweden)

    Muhammad Ubayyu Rikza

    2017-12-01

    Full Text Available The Constitutional Court made a revolutionary decision through the decision of Constitutional Court Number 46/PUU-VIII/2010 about the status of children outside of marriage. The decision stated that childrens born outside of marriage not only had a civil relationship with their mother and mother's family but also had a civil relationship with their biological father. Its implicates that children outside of marriage have the same rights with legal children, such as  earning a living, inheritance and equality before the law. Seen from the concept of maqâṣid asy-syarî'ah, the decision does not violate the Islamic law, otherwhise it is in the line with the principles of maqâṣid asy-syarî'ah especially the principles of ḥifẓ an-nasl and ḥifẓ an-nafs.   [Mahkamah Konstitusi telah membuat putusan revolusioner dalam putusan MK Nomor 46/PUU-VIII/2010 tentang status anak di luar perkawinan. Putusan tersebut menyatakan bahwa anak yang dilahirkan di luar perkawinan mempunyai hubungan perdata dengan ibu dan keluarga ibunya dan mempunyai hubungan perdata dengan ayah biologisnya yang dibuktikan berdasarkan ilmu pengetahuan dan teknologi. Implikasinya adalah anak di luar perkawinan mendapat hak sama dengan anak sah, mendapatkan nafkah, waris dan persamaan di hadapan hukum. Dilihat dari konsep maqâṣid asy-syarî’ah, putusan tersebut tidak melanggar hukum Islam, sebaliknya, ia sejalan dengan prinsip-prinsip maqâṣid asy-syarî’ah terutama prinsip ḥifẓ an-nasl dan ḥifẓ an-nafs.

  12. Driven equilibrium (drive) MR imaging of the cranial nerves V-VIII: comparison with the T2-weighted 3D TSE sequence

    Energy Technology Data Exchange (ETDEWEB)

    Ciftci, E. E-mail: eciftcis7@hotmail.com; Anik, Yonca; Arslan, Arzu; Akansel, Gur; Sarisoy, Tahsin; Demirci, Ali

    2004-09-01

    Purpose: The aim of this study is to evaluate the efficacy of the driven equilibrium radio frequency reset pulse (DRIVE) on image quality and nerve detection when used in adjunction with T2-weighted 3D turbo spin-echo (TSE) sequence. Materials and methods: Forty-five patients with cranial nerve symptoms referable to the cerebellopontine angle (CPA) were examined using a T2-weighted 3D TSE pulse sequence with and without DRIVE. MR imaging was performed on a 1.5-T MRI scanner. In addition to the axial resource images, reformatted oblique sagittal, oblique coronal and maximum intensity projection (MIP) images of the inner ear were evaluated. The nerve identification and image quality were graded for the cranial nerves V-VIII as well as inner ear structures. These structures were chosen because fluid-solid interfaces existed due to the CSF around (the cranial nerves V-VIII) or the endolymph within (the inner ear structures). Statistical analysis was performed using the Wilcoxon test. P<0.05 was considered significant. Results: The addition of the DRIVE pulse shortens the scan time by 25%. T2-weighted 3D TSE sequence with DRIVE performed slightly better than the T2-weighted 3D TSE sequence without DRIVE in identifying the individual nerves. The image quality was also slightly better with DRIVE. Conclusion: The addition of the DRIVE pulse to the T2-weighted 3D TSE sequence is preferable when imaging the cranial nerves surrounded by the CSF, or fluid-filled structures because of shorter scan time and better image quality due to reduced flow artifacts.

  13. Crystal Structures of Brain Group-VIII Phospholipase A2 in Non-aged Complexes with the Organophosphorus Nerve Agents Soman and Sarin†‡

    Science.gov (United States)

    Epstein, Todd M.; Samanta, Uttamkumar; Kirby, Stephen D.; Cerasoli, Douglas M.; Bahnson, Brian J.

    2009-01-01

    Insecticide and nerve agent organophosphorus compounds are potent inhibitors of the serine hydrolase superfamily of enzymes. Nerve agents, such as sarin, soman, tabun and VX exert their toxicity by inhibiting human acetycholinesterase at nerve synapses. Following the initial phosphonylation of the active site serine, the enzyme may reactivate spontaneously or through reaction with an appropriate nucleophilic oxime. Alternatively, the enzyme-nerve agent complex can undergo a secondary process, called “aging”, which dealkylates the nerve agent adduct and results in a product that is highly resistant to reactivation by any known means. Here we report the structures of paraoxon, soman and sarin complexes of group-VIII phospholipase A2 from bovine brain. In each case, the crystal structures indicate a non-aged adduct; a stereoselective preference for binding of the PSCS isomer of soman and the PS isomer of sarin was also noted. The stability of the non-aged complexes was corroborated by trypsin digest and electrospray ionization mass spectrometry, which indicates non-aged complexes are formed with diisopropylfluorophosphate, soman and sarin. The PS stereoselectivity for reaction with sarin was confirmed by reaction of racemic sarin, followed by gas chromatography/mass spectrometry using a chiral column to separate and quantitate each stereoisomer. The PS stereoisomers of soman and sarin are known to be the more toxic stereoisomers, as they react preferentially to inhibit human acetylcholinesterase. The results obtained for non-aged complexes of group-VIII phospholipase A2 are compared to those obtained for other serine hydrolases and discussed to partly explain determinants of OP aging. Furthermore, structural insights can now be exploited to engineer variant versions of this enzyme with enhanced nerve agent binding and hydrolysis functions. PMID:19271773

  14. Crystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin.

    Science.gov (United States)

    Epstein, Todd M; Samanta, Uttamkumar; Kirby, Stephen D; Cerasoli, Douglas M; Bahnson, Brian J

    2009-04-21

    Insecticide and nerve agent organophosphorus (OP) compounds are potent inhibitors of the serine hydrolase superfamily of enzymes. Nerve agents, such as sarin, soman, tabun, and VX exert their toxicity by inhibiting human acetycholinesterase at nerve synapses. Following the initial phosphonylation of the active site serine, the enzyme may reactivate spontaneously or through reaction with an appropriate nucleophilic oxime. Alternatively, the enzyme-nerve agent complex can undergo a secondary process, called "aging", which dealkylates the nerve agent adduct and results in a product that is highly resistant to reactivation by any known means. Here we report the structures of paraoxon, soman, and sarin complexes of group-VIII phospholipase A2 from bovine brain. In each case, the crystal structures indicate a nonaged adduct; a stereoselective preference for binding of the P(S)C(S) isomer of soman and the P(S) isomer of sarin was also noted. The stability of the nonaged complexes was corroborated by trypsin digest and electrospray ionization mass spectrometry, which indicates nonaged complexes are formed with diisopropylfluorophosphate, soman, and sarin. The P(S) stereoselectivity for reaction with sarin was confirmed by reaction of racemic sarin, followed by gas chromatography/mass spectrometry using a chiral column to separate and quantitate each stereoisomer. The P(S) stereoisomers of soman and sarin are known to be the more toxic stereoisomers, as they react preferentially to inhibit human acetylcholinesterase. The results obtained for nonaged complexes of group-VIII phospholipase A2 are compared to those obtained for other serine hydrolases and discussed to partly explain determinants of OP aging. Furthermore, structural insights can now be exploited to engineer variant versions of this enzyme with enhanced nerve agent binding and hydrolysis functions.

  15. Direito à saúde: o Sistema Único de Saúde (SUS) está em risco?

    OpenAIRE

    Campos, Gastão Wagner de Sousa; Bedrikow, Rubens; Santos, Júlia Amorim; Terra, Lilian Soares Vidal; Fernandes, Juliana Azevedo; Borges, Fabiano Tonaco

    2016-01-01

    O coletivo de Estudos e Apoio Paideia propôs o seminário “Direito à Saúde: o SUS está em risco?” para ampliar o debate com os atores sociais sobre os impasses atuais do Sistema Único de Saúde (SUS) e os caminhos possíveis para a concretização do direito à saúde. Os participantes apresentaram propostas concretas que nos guiam para uma maior participação política e aprofundamento da democracia no SUS. The Paideia Collective of Research Support proposed the seminar “Right to Health Care: Is t...

  16. Total cross-sections assessment of neutron reaction with stainless steel SUS-310 contained in various nuclear data files

    International Nuclear Information System (INIS)

    Suwoto

    2002-01-01

    The integral testing of neutron cross-sections for Stainless Steel SUS-310 contained in various nuclear data files have been performed. The shielding benchmark calculations for Stainless Steel SUS-310 has been analysed through ORNL-Broomstick Experiment calculation which performed by MAERKER, R.E. at ORNL - USA ( 1) . Assessment with JENDL-3.1, JENDL-3.2, ENDF/B-IV, ENDF/B-VI nuclear data files and data from GEEL have also been carried out. The overall calculation results SUS-310 show in a good agreement with the experimental data, although, underestimate results appear below 3 MeV for all nuclear data files. These underestimation tendencies clearly caused by presented of iron nuclide which more than half in Stainless Steel compound. The total neutron cross-sections of iron nuclide contained in various nuclear data files relatively lower on that energy ranges

  17. Actitud del estudiante de ingeniería hacia sus errores en el aprendizaje de la matemática

    Directory of Open Access Journals (Sweden)

    Lissette Franchi Boscán

    2011-09-01

    Full Text Available Bajo cualquier esquema de enseñanza-aprendizaje de la matemática, cuando al alumno se le señalan errores en su trabajo, puede, en general, adoptar tres tipos de actitud: una actitud negativa, bajo la cual el alumno considera que sus errores son sencillamente un síntoma de su fracaso; una actitud neutra o indiferente ante sus errores; o una actitud positiva, considerándolos como un medio para aprender y planteándose como reto el superarlos. Este artículo muestra una investigación que abordó el estudio de actitudes vinculadas al proceso de aprendizaje de la matemática. Su objetivo fue describir la actitud que el estudiante de ingeniería de la Uni- versidad del Zulia exhibe frente a sus errores cuando aprende matemática. La sus tentación teórica se baso en Brousseau (2001, Briñol et al. (2007 y los autores Pallí y Martínez (2004. Se utilizó una escala AEAM (Actitud hacia el Error del Alumno de Matemática, tipo Likert con 6 alternativas de respuesta que consta de 36 ítems, en su segunda versión, actualizada por los autores. El instrumento fue validado mediante juicio de expertos y se determinó que era de alta confiabilidad, con un alpha de Cronbach de 0.9073. Se concluyó que los participantes, en su mayoría, mostraron una actitud moderadamente positiva hacia sus errores, que al no estar ubicada en el extremo positivo deseable refleja una actitud débil que no garantiza una conducta adecuada hacia los errores, pero que sin embargo es sus ceptible de ser mejorada hacia una actitud francamente positiva.

  18. LAS CREENCIAS SOBRE OBESIDAD DE NIÑOS Y NIÑAS EN EDAD ESCOLAR Y LAS DE SUS PROGENITORES

    Directory of Open Access Journals (Sweden)

    Hilda Patricia Núñez Rivas

    2013-01-01

    Full Text Available El propósito de este artículo es evidenciar, mediante el método etnográfico, las creencias sobre la obesidad de niños y niñas en edad escolar y las de sus progenitores, pertenecientes a una escuela urbana y pública de San José, Costa Rica. Los resultados apuntan hacia las creencias negativas de la niñez respecto a sus pares con obesidad y sus implicaciones psicosociales y afectivas. En relación con los progenitores se señalan las causas y estrategias de control, las implicaciones de la obesidad, referente a enfermedades físicas y emocionales; el papel del hogar y de la escuela en su prevención. Se concluye que los niños y las niñas creen que la obesidad no es una enfermedad, sino u na expresión fenotípica, a la cual le dan grado de relatividad o de escala y la consideran no deseable, resultado que concuerda con la de sus progenitores. Las niñas participantes con obesidad expresaron sus posiciones de defensa y molestia, en relación con experiencias burlescas. Al contrario de sus hijos e hijas, la mayoría de los progenitores sí cree que la obesidad es una enfermedad o un problema de salud o de estética. Además, estiman que esta se controla utilizando una dieta saludable y equilibrada, dando consejos sobre las consecuencias físicas y emocionales de la obesidad y ofreciendo modelos de personas saludables. Por lo tanto, los progenitores y el personal docente creen que la escuela poco puede hacer respecto a la alimentación saludable del alumnado, pues el hogar es el lugar que tiene un papel primordial.

  19. Seres monstruosos y cuerpos fragmentados. Sus representaciones en dos relatos fantásticos de Alberto Chimal

    OpenAIRE

    Caamaño M., Virginia

    2014-01-01

    En este estudio se analizan las estrategias formales y discursivas por medio de las cuales se construyen dos textos fantásticos del mexicano Alberto Chimal y se señalan sus rasgos específicos. Se destaca como eje fundamental de los relatos las actuaciones de sus protagonistas, quienes aparecen como monstruos, cuya presencia posibilita la irrupción de lo fantástico, la ambigüedad y lo siniestro. This study analyzes the formal and discursive strategies through which two fantasy texts by Mexi...

  20. La Asociación Latinoamericana de Sociología: una historia de sus primeros congresos

    Directory of Open Access Journals (Sweden)

    Blanco Alejandro

    2005-01-01

    Full Text Available El examen de las asociaciones nacionales y regionales de sociología de América Latina, de su estructura y composición como de sus transformaciones es, todavía hoy, una asignatura pendiente en la historia de la disciplina. Este trabajo reconstruye la historia de los primeros años de la Asociación Latinoamericana de Sociología, intentando caracterizar su contexto de emergencia, sus principales rasgos y su papel en la formación de la sociología de la región.

  1. Libros adquiridos por don Pedro Fermín de Vargas en sus viajes por las Antillas

    Directory of Open Access Journals (Sweden)

    Sergio Elías Ortíz

    1962-04-01

    Full Text Available Entre los papeles relacionados con la vida de Don Pedro Fermín de Vargas, que pueden consultarse en el Archivo General de Indias de Sevilla, hay una carta de él y una lista de libros que envía al Administrador de Correos de la Habana, Don José Fuertes, antiguo amigo suyo, luego su corresponsal y a la  vez espía de sus pasos para aprisionarlo, con el objeto de que se los guardase “en algún rincón de sus casa”.

  2. Procedimiento para obtener un producto prebiótico de alto contenido en fibra soluble, dicho producto y sus aplicaciones

    OpenAIRE

    Rupérez Antón, Pilar; Mateos-Aparicio, Inmaculada

    2008-01-01

    Procedimiento para obtener un producto prebiótico de alto contenido en fibra soluble, dicho producto y sus aplicaciones. La presente invención describe un procedimiento para obtener un producto prebiótico de alto contenido en fibra soluble a partir del uso de fibra insoluble proveniente de residuos vegetales y de la aplicación de altas presiones. Así sus aplicaciones son como suplemento dietético natural rico en fibra en alimentos utilizándose a residuos de soja, subpr...

  3. La Modernidad y Sus Dilemas en la Era Del Mercado: ¿Hay Algún Futuro Posible?

    OpenAIRE

    Ibarra-Colado,Eduardo

    2010-01-01

    El trabajo discute a la globalización como el momento moderno que exacerba sus contradicciones, en tanto, proyecto civilizatorio basado en la ética de la dominación. Al iniciar en la conquista, se plantea la esencia de la modernidad como un proyecto basado en la fuerza y la violencia. Al imponerse hacia fuera, la modernidad inició sus propias disputas internas, que se tradujeron en la confrontación de dos proyectos, el basado en la razón instrumental y el mercado; y el basado en la razón de e...

  4. The Osteometrical Characteristics of Mandibles of Sus Scrofa Population in the Czech Republic (České Budějovice) in Comparison with Sus Scrofa Population in Chile and Japan

    Czech Academy of Sciences Publication Activity Database

    Dvořáková-Líšková, Zuzana; Hanzal, V.; Janiszewski, P.

    3/13, č. 3 (2007), s. 42-51 ISSN 0909-6396 R&D Projects: GA MŠk(CZ) 1P05OC060 Institutional research plan: CEZ:AV0Z60870520 Keywords : Sus Scrofa * osteometry Subject RIV: EG - Zoology Impact factor: 0.894, year: 2007

  5. Obtenção e caracterização de anticorpo monoclonal murino anti-fator VIII da coagulação sangüínea Attainment and characterization of murine monoclonal anti-factor VIII antibodies

    Directory of Open Access Journals (Sweden)

    Rosana Rossi-Ferreira

    2006-06-01

    Full Text Available Entre os avanços da engenharia celular e biotecnologia nas últimas décadas, destaca-se a produção de anticorpos monoclonais murinos (AcMm utilizados no aprimoramento diagnóstico nas rotinas laboratoriais. A produção de fator VIII de alta pureza sempre foi o desejo e a preocupação das indústrias de hemoderivados para tratamento de pacientes portadores de hemofilia A, porém este produto inexiste no Brasil, sendo necessária sua obtenção no mercado internacional a custos elevados. O trabalho tem por objetivo a produção de AcMm anti-fator VIII humano (FVIII H através da expansão dos clones e caracterização imunoquímica do anticorpo. Camundongos Balb/c foram imunizados com FVIII H purificado como também proveniente de crioprecipitado e as células esplênicas dos animais foram fusionadas com células mielomatosas murinas segundo o método descrito por Kohler e Milstein para produção de híbridos em cultura. Foram testados 1.983 híbridos dos quais 105 foram submetidos à clonagem. Destes, 39 obtiveram monoclonalidade e 7 destes clones foram caracterizados através de técnicas de immunoblotting. Foram submetidas à purificação por cromatografia três imunoglobulinas de diferentes classes pertencentes aos clones LAMB1-10A1A4, LAMB1-17A1A1 e LAMB1-24A2A1. A imunoglobulina purificada pertencente ao clone LAMB1-10A1A4 foi adsorvida em coluna de imunoafinidade para purificação de concentrado de FVIII proveniente de crioprecipitado plasmático.Among the advances in cellular engineering and biotechnology over the last decades, the production of murine monoclonal antibodies (AcMm, used to improve laboratory diagnoses, stands out. The production of very pure factor VIII has always been a concern of suppliers of blood products to treat patients with hemophilia A and this product is still not produced in Brazil. Hence, it can only be attained on the international market at a high cost. The aim of this work was to produce AcMm anti

  6. Low-cycle fatigue properties of SUS304 stainless steel in high-temperature sodium

    International Nuclear Information System (INIS)

    Hirano, M.; Komine, R.; Kitao, K.; Nihei, I.; Yoshitoshi, A.

    Low-cycle fatigue tests in sodium and in air have been performed to investigate the influence of a high-temperature sodium environment on the strain-controlled fatigue behaviour for SUS304 stainless steel. The oxygen concentration in sodium was 2.4 ppm at the cold trap temperature of 145 deg. C. Tests in both environments were conducted at 450 deg. C, 550 deg. C and 650 deg. C at a constant strain rate of 1x10 -3 /sec with a fully-reversed triangular waveform and a zero mean strain. The fatigue life of SUS304 stainless steel in sodium at 450 deg. C, 550 deg. C and 650 deg. C was greater than those in air at the same temperature except at higher strain range (>0.8%) at 650 deg. C, and this difference had a tendency to increase as the total strain range decreases. At the higher total strain range at 650 deg. C, there was no marked difference between both environments. As the temperature increased, the fatigue life in sodium and in air decreased, and the Nsub(f sodium)/Nsub(f air) ratio also decreased. Microscopic examination of specimens tested in sodium and in air at 450 deg. C, 550 deg. C and 650 deg. C revealed no difference in the microstructure, but few surface cracks were observed on specimens tested in sodium than in those tested in air. Fractography of specimens tested in air at 450 deg. C, 550 deg. C and 650 deg. C revealed well-defined striations. But, in sodium, striations on specimens tested at 450 deg. C and 550 deg. C showed obscure configuration and it was difficult to find out, whereas, at 650 deg. C in sodium intergranular fracture was observed. The specimens tested in sodium had a longer fatigue life than those tested in air because the latter are subjected to considerable oxidation, while the former are free of such chemical action. Accordingly, it is concluded that crack initiation and propagation are more likely to occur in air than in sodium. (author)

  7. El repertorio sefardí en sus géneros poéticomusicales

    Directory of Open Access Journals (Sweden)

    Weich-Shahak, Susana

    2009-12-01

    Full Text Available In the communities that the Jews expelled from Spain established in their new diasporas, the Sephardi Jews preserved the memory of Medieval Spain. For five centuries they kept alive the language that they had spoken in the different regions of the Iberian Peninsula where they lived before their “exodus” and later on incorporated words and expressions from the languages of the peoples among whom they lived. They also preserved the musical repertoire that they brought from Spain and they transmitted it orally from generation to generation. This article deals with the three main genres that constitute the Judeo- Spanish musico-poetic repertoire: the Romancero, Coplas and Cancionero, presenting the criteria for their classification and pointing out the specific characteristics of each of them. Being the Romancero the genre with the deepest Hispanic roots, we offer here some concordances between the Sephardi Romancero and the romances collected from the oral tradition in Galicia.

    En las comunidades que los judíos expulsados de la Península establecieron en sus nuevas diásporas, los sefarditas preservaron la memoria de la España medieval. Durante cinco siglos mantuvieron viva la lengua que hablaran en las distintas regiones de la Península Ibérica donde habitaran antes de su “éxodo, incorporando al Judeo-español términos tomados de las lenguas habladas por los pueblos con los cuales los judíos sefarditas convivían. Llevaron asimismo el repertorio musical que conocieran, transmitiéndolo oralmente de generación en generación y enriqueciéndolo con eventuales creaciones. Este artículo se ocupa de los tres principales géneros poético-musicales que componen el repertorio sefardí: los romances, las coplas y las cantigas, exponiendo los criterios para la definición de los géneros y los rasgos que identifican a cada uno de ellos. Siendo el Romancero sefardí el que más evidencia sus raíces hispánicas, se ofrecen aqu

  8. GENERALIDADES DE LOS UREDINALES(Fungi: Basidiomycota Y DE SUS RELACIONES FILOGENÉTICAS

    Directory of Open Access Journals (Sweden)

    CATALINA MARÍA ZULUAGA

    2009-01-01

    Full Text Available RESUMEN Los hongos-roya (Uredinales, Basidiomycetes representan uno de los grupos de microorganismos fitoparásitos más diversos y con mayor importancia económica mundial en la producción agrícola y forestal. Se caracterizan por ser patógenos obligados y por presentar una estrecha coevolución con sus hospedantes vegetales. Su taxonomía se ha basado fundamentalmente en el estudio de caracteres morfológicos, resultando en muchos casos en la formación de taxones polifiléticos. Sin embargo, en los últimos años se han tratado de incorporar herramientas moleculares que conduzcan a la generación de sistemas de clasificación basados en afinidades evolutivas. En esta revisión se ofrece una mirada general a las características de los uredinales, enfatizando en el surgimiento reciente de estudios filogenéticos que plantean la necesidad de establecer una profunda revisión de la taxonomía de este grupo. Finalmente se alerta sobre la necesidad de que en dichos estudios taxonómicos se incluya un alto número de especies de royas neotropicales, pues esta zona es reconocida no sólo por su alta diversidad de hongos-royas, sino también por las características únicas de sus ciclos de vida. Palabras clave: filogenia, hongos-roya, Puccinia, secuenciación, teliosporas. ABSTRACT Rust fungi (Uredinales, Basidiomycetes are one of the most diverse and economically important plant pathogens of crops world-wide. They are obligated parasites and have a close evolutionary relationship with their plant hosts. Taxonomy of this group has been based on morphological treats, resulting in generation of polyphyletic taxa. Recently, different studies have incorporated molecular techniques addressed to establishing evolutionary affinities between these fungi. This review presents a general view of the biological characteristics of rust fungi, with a detailed discussion on the phylogenetic studies regarding the group. Finally, the review proposes the necessity

  9. Demandas judiciais de medicamentos no SUS do Tocantins: contexto e perspectivas

    Directory of Open Access Journals (Sweden)

    Elizangela Braga Andrade

    2013-12-01

    Full Text Available A interferência do Poder Judiciário no âmbito das políticas públicas constitui importante paradigma da gestão do Sistema Único de Saúde (SUS. O medicamento, fundamental na assistência à saúde, tornou-se frequente objeto requerido nas ações judiciais nas três esferas de gestão. Este artigo apresenta e discute os resultados preliminares de um estudo que analisou as demandas judiciais contra a Secretaria de Estado da Saúde do Tocantins, para fornecimento de medicamentos, de janeiro/2007 a dezembro/2009. Das 166 apresentações de medicamentos e 104 princípios ativos demandados, 161 apresentações (97% possuíam registro no Brasil. Ao correlacionar patologia diagnosticada com bulas dos medicamentos, 83% apresentavam indicação correlacionada, contra 17% sem indicação presente; inclusive 3% eram contraindicados. Consultórios e hospitais particulares responderam por 49% das prescrições de medicamentos, e postos de saúde, hospitais públicos e universidade representaram 50% das prescrições. Pneumologia, Cancerologia, Neurologia, Reumatologia e Psiquiatria foram as especialidades mais frequentes. Ministério Público e Defensoria Pública foram os principais autores dos processos judiciais (83% e escritórios particulares de advocacia responderam por 15% das ações. Os requerentes que mais demandaram estão nas faixas etárias de 1 a 19 anos (37% e de 61 a 82 anos (23%. Os gastos com medicamentos decorrentes de ações judiciais foram crescentes nos anos estudados. Os dados e propostas de melhoria aqui apresentados poderão contribuir para medidas adequadas e estratégias oportunas de aprimoramento da Política Estadual de Saúde, especialmente maior acesso à Assistência Farmacêutica o que representa, ainda, um grande e atual desafio do SUS.

  10. ¿Cómo escribir lo social después de la performatividad y sus obstrucciones?

    DEFF Research Database (Denmark)

    Ossandón, José

    2015-01-01

    a grandes rasgos similar, presentan diferentes formas de componer y demostrar sus tesis por escrito. Usando categorías tradicionales para distinguir géneros literarios, se puede decir que se encontraron libros de teoría social escritos como ensayo, como novela y como fábula. Segundo, a partir de una lectura...

  11. Augusto Comte y sus discípulos ortodoxos frente a la cuestión colonial

    Directory of Open Access Journals (Sweden)

    Tonatiuh Useche Sandoval

    2015-01-01

    Full Text Available Este artículo presenta la oposición de Augusto Comte y sus discípulos al movimiento colonizador que emanó del Occidente europeo durante el siglo XIX. Aunque considera Europa como el centro de la Humanidad, Comte sostiene que la contribución europea al progreso de los pueblos menos avanzados no reside en la dominación colonial, sino en la difusión pacífica de una doctrina demostrable. En un primer momento se resume la apreciación globalmente negativa de Comte sobre la colonización moderna; luego se evocan sus propuestas para valorar a los colonizados y combatir los argumentos colonialistas; finalmente se toma el caso de la conquista francesa de Argelia para comparar la posición de Comte con la de Tocqueville y la de Enfantin. En un segundo momento se subraya la influencia moral que sus discípulos ejercieron en Inglaterra en contra de la colonización exterior. Se insiste después en el papel significativo que jugaron sus discípulos brasileros en contra de la colonización interior y en pro de la protección de los indígenas. Se concluye que el positivismo de Comte constituye una forma de eurocentrismo anticolonial.

  12. Role of the mRNA export factor Sus1 in oxidative stress tolerance in Candida albicans.

    Science.gov (United States)

    Xiao, Chenpeng; Yu, Qilin; Zhang, Bing; Li, Jianrong; Zhang, Dan; Li, Mingchun

    2018-02-05

    In eukaryotes, the nuclear export of mRNAs is essential for gene expression. However, little is known about the role of mRNA nuclear export in the important fungal pathogen, Candida albicans. In this study, we identified C. albicans Sus1, a nucleus-localized protein that is required for mRNA export. Interestingly, the sus1Δ/Δ displayed hyper-sensitivity to extracellular oxidative stress, enhanced ROS accumulation and severe oxidative stress-related cell death. More strikingly, although the mutant exhibited normal activation of the expression of oxidative stress response (OSR) genes, it had attenuated activity of ROS scavenging system, which may be attributed to the defect in OSR mRNA export in this mutant. In addition, the virulence of the sus1Δ/Δ was seriously attenuated. Taken together, our findings provide evidence that the mRNA export factor Sus1 plays an important role in oxidative stress tolerance and pathogenesis. Copyright © 2018 Elsevier Inc. All rights reserved.

  13. Do changes in soil properties after rooting by wild boars (Sus scrofa) affect understory vegetation in Swiss hardwood forests?

    Science.gov (United States)

    Sven Wirthner; Martin Schutz; Deborah S. Page-Dumroese; Matt D. Busse; James W. Kirchner; Anita C. Risch

    2012-01-01

    Recovering from small fragmented populations, wild boars (Sus scrofa L.) have considerably increased their numbers and their habitat range in many European countries during the past two decades. Although several studies have focused on the impact of wild boar rooting on selected vegetation properties, little is known about effects on entire forest ecosystems. The main...

  14. La diégesis cinematográfica y sus implicaciones didácticas

    Directory of Open Access Journals (Sweden)

    Juan de PABLOS PONS

    2009-11-01

    Full Text Available El cine como «lenguaje universal» ha desarrollado y perfeccionado en sus casi cien años de existencia una capacidad comunicativa que ha sido explotada fundamentalmente desde la faceta del cine-ficción, pero también desde otras, como el periodismo audiovisual, la publicidad o la creación videografica. Colateralmente, el cine producido con fines educativos también es deudor de la eficacia comunicativa lograda por la evolución cinematográfica. Independientemente de que el mensaje audiovisual pueda ser presentado en soporte fotoquímico, electromagnético o emitido (por cable, vía satélite, televisión convencional, etc., la «escritura cinematográfica» deviene en un factor clave en el mundo de la comunicación actual, dado que la gran mayoría de las propuestas audiovisuales toman como base la narratividad cinematográfica.

  15. High frequency magnetotelluric and geoelectric researches in the Provita de Sus landslide area

    Science.gov (United States)

    Diacopolos, Constantin

    2010-05-01

    In the Provita de Sus area, high frequency magnetotelluric and geoelectric (Vertical Electric Soundings) measurements have been performed in order to delineate the landslide area. The high frequency magnetotelluric method uses the time variations of the natural electromagnetic field propagating inside the Earth and induces a secondary electromagnetic field, measured at the surface by special devices, in order to investigate the Earth's shallow electric conductivity structure. We performed these measurements aiming to point out the slide interface, as well as its the depth, and to establish the dip and strike of a relatively evident fault system from the studied area. The high frequency magnetotelluric data have been obtained in the frequency range 24 KHz - 1Hz by using a GMS 06 devices and the MAPROS software. For the geoelectric measurements we used the IntV3 resistivimeter, Schlumberger type array. This device version is designed for geophysical appliances allowing the soil resistivity measurements, under natural conditions of climate and land morphology. The field measurements led to a series of potential difference values expressed in micro V. The interpretation is based on the apparent resistivity resulting from the field measurements by using standard relation. The results highlight the usefulness of the geoelectric method for the landslide areas delineation, taking into account its user-friendliness, having all the technical facilities for measurement, processing and interpretation. The results are presented along two resistivity cross-sections, placed perpendicular and parallel to landslide surface.

  16. GEL OBTENIDO TRIBOQUÍMICAMENTE Y ELUCIDACIÓN DE SUS COMPONENTES

    Directory of Open Access Journals (Sweden)

    Lilia Fernández

    2012-01-01

    Full Text Available El presente trabajo tiene como objetivo reportar un gel obtenido triboquimicamente en la reacción de Cannizzaro y la elucidación de sus componentes. La reacción entre benzaldehido e hidróxido de sodio llevada a cabo sin disolvente y agitando las fases (método triboquímico forma una suspensión que reacciona rápidamente (1 minuto, produciendo un gel blanco, el análisis infrarrojo arroja alcohol bencílico y benzoato de sodio. La difracción de rayos X confirma la fase continua del gel como benzoato de so dio. El análisis micrográfico del gel muestra una fase amorfa correspondiente al benzoato de sodio. La exposición del gel triboquímico a un rayo láser permite observar la dispersión de la luz. La técnica triboquímica es un proceso limpio acorde con los principios de la química verde. La espectroscopía en fa se sólida y de los líquidos sin disolventes contribuye al desarrollo de una química analítica verde.

  17. Introducción a los algoritmos genéticos y sus aplicaciones

    Directory of Open Access Journals (Sweden)

    Piedad Tolmos Rodríguez-Piñero

    2002-01-01

    Full Text Available Los algoritmos genéticos son un logro más de la Inteligencia Artificial en su intento de replicar comportamientos biológicos, con los avances científicos que ello implica, mediante la computación. Se trata de algoritmos de búsqueda basados en la mecánica de la selección natural y de la genética. Utilizan la información histórica para encontrar nuevos puntos de búsqueda de una solución óptima del problema planteado, con esperanzas de mejorar los resultados. En el presente artículo se realizará una introducción a los Algoritmos Genéticos: qué son, de dónde proceden, y en qué difieren de otros métodos de búsqueda, comentándose, asimismo, sus aplicaciones principales.

  18. Gestão e subjetividade no SUS: o enfrentamento de impasses em tempos neoliberais

    Directory of Open Access Journals (Sweden)

    João Leite Ferreira Neto

    2014-12-01

    Full Text Available O objetivo deste artigo é analisar processos de gestão e subjetividade no SUS, com base no reconhecimento da existência de dois modelos distintos. O primeiro é o preconizado pela Reforma Sanitária; o segundo, de corte neoliberal, é assumido pelo setor privado, mas afeta o contexto da saúde pública, dificultando seus avanços. O neoliberalismo é discutido como estratégia de governo dos homens, possuindo uma política de subjetivação individualista. São analisadas as propostas do movimento sanitário de gestão democrática e subjetividade solidária e seus impasses. Conclui-se que as saídas não se darão exclusivamente a partir de arranjos macropolíticos e devem incluir a construção efetiva de modos de gestão e de subjetividade que permitam aos indivíduos e aos coletivos reinventarem-se de forma crítica e solidária.

  19. CLÍNICA DO TRABALHO NO SUS: POSSIBILIDADE DE ESCUTA AOS TRABALHADORES

    Directory of Open Access Journals (Sweden)

    Carla Garcia Bottega

    Full Text Available Resumo Este artigo discute a saúde do trabalhador e mais especificamente os aspectos relativos à saúde mental relacionada ao trabalho, a partir de entrevistas com 24 trabalhadores e trabalhadoras em situação de sofrimento e adoecimento. A utilização de um roteiro de entrevistas e o uso conjunto do SRQ-20 possibilitaram o entendimento da história do trabalhador, sua relação com o trabalho e de sua saúde em intrínseca associação com o vivido no espaço laboral. A proposta é que a discussão e os instrumentos utilizados possam servir para profissionais da saúde que necessitam fazer investigação diagnóstica da relação saúde mental e trabalho, além de trazer importantes questionamentos para construir uma proposta de acompanhamento terapêutico para o trabalhador ou trabalhadora que busca o serviço. O objetivo maior é o de subsidiar a construção de propostas para uma clínica em saúde mental e trabalho para os serviços do Sistema Único de Saúde (SUS.

  20. Light-absorbing Aerosol Properties in the Kathmandu Valley during SusKat-ABC Field Campaign

    Science.gov (United States)

    Kim, S.; Yoon, S.; Kim, J.; Cho, C.; Jung, J.

    2013-12-01

    Light-absorbing aerosols, such as black carbon (BC), are major contributors to the atmospheric heating and the reduction of solar radiation reaching at the earth's surface. In this study, we investigate light-absorption and scattering properties of aerosols (i.e., BC mass concentration, aerosol solar-absorption/scattering efficiency) in the Kathmandu valley during Sustainable atmosphere for the Kathmandu valley (SusKat)-ABC campaign, from December 2012 to February 2013. Kathmandu City is among the most polluted cities in the world. However, there are only few past studies that provide basic understanding of air pollution in the Kathmandu Valley, which is not sufficient for designing effective mitigation measures (e.g., technological, financial, regulatory, legal and political measures, planning strategies). A distinct diurnal variation of BC mass concentration with two high peaks observed during wintertime dry monsoon period. BC mass concentration was found to be maximum around 09:00 and 20:00 local standard time (LST). Increased cars and cooking activities including substantial burning of wood and other biomass in the morning and in the evening contributed to high BC concentration. Low BC concentrations during the daytime can be explain by reduced vehicular movement and cooking activities. Also, the developmements of the boundary layer height and mountain-valley winds in the Kathmandu Valley paly a crucial role in the temproal variation of BC mass concentrations. Detailed radiative effects of light-absorbing aerosols will be presented.